# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF5623 PF18536.1 EDN02137.1 - 0.14 12.4 0.1 0.23 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5623) Sugar_tr PF00083.24 EDN02138.1 - 2.1e-75 254.4 14.2 2.9e-75 253.8 14.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN02138.1 - 1.7e-12 46.9 28.4 4.3e-12 45.6 28.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Oxysterol_BP PF01237.18 EDN02139.1 - 1.3e-52 178.9 1.8 3.3e-45 154.5 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein RTA1 PF04479.13 EDN02140.1 - 5.1e-50 169.9 16.9 7.5e-50 169.4 16.9 1.2 1 0 0 1 1 1 1 RTA1 like protein TMEM208_SND2 PF05620.11 EDN02140.1 - 0.013 15.3 0.0 0.013 15.3 0.0 3.8 2 2 2 5 5 5 0 SRP-independent targeting protein 2/TMEM208 CUE PF02845.16 EDN02141.1 - 1.3e-09 37.5 0.0 2.3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF3697 PF12478.8 EDN02141.1 - 0.042 14.0 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-associated protein 2 HJURP_mid PF12346.8 EDN02143.1 - 0.99 9.9 6.2 0.1 13.0 1.0 1.8 1 1 0 2 2 2 0 Holliday junction recognition protein-associated repeat Spore_coat_CotO PF14153.6 EDN02143.1 - 6.7 6.6 11.5 7.4 6.5 11.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO UCH PF00443.29 EDN02144.1 - 2.2e-35 122.4 0.2 3.4e-30 105.4 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN02144.1 - 2.7e-07 30.5 1.8 2.7e-07 30.5 1.8 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Cytochrome_C7 PF14522.6 EDN02144.1 - 0.11 12.6 2.4 0.36 10.8 0.8 2.6 3 0 0 3 3 3 0 Cytochrome c7 and related cytochrome c Methyltransf_23 PF13489.6 EDN02145.1 - 4.2e-11 43.0 0.0 6.1e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN02145.1 - 4.9e-05 23.2 0.0 8.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN02145.1 - 0.0011 19.6 0.0 0.0026 18.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN02145.1 - 0.0037 17.9 0.0 0.0074 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN02145.1 - 0.0077 17.0 0.0 0.027 15.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain F_bP_aldolase PF01116.20 EDN02146.1 - 5.1e-65 219.7 0.0 6.1e-65 219.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II RSN1_7TM PF02714.15 EDN02148.1 - 1.6e-80 270.4 26.3 2.8e-80 269.6 26.3 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDN02148.1 - 1e-40 139.1 2.5 1e-40 139.1 2.5 2.5 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDN02148.1 - 9.6e-38 130.1 0.0 1.6e-37 129.4 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF1192 PF06698.11 EDN02148.1 - 0.049 13.7 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) ABC_tran_CTD PF16326.5 EDN02148.1 - 0.19 12.0 0.0 5.1 7.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF2244 PF10003.9 EDN02148.1 - 9.5 5.9 6.9 3.6 7.2 2.9 2.4 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) DUF3445 PF11927.8 EDN02149.1 - 2.1e-79 266.3 0.1 3e-79 265.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Homoserine_dh PF00742.19 EDN02150.1 - 5.4e-52 176.2 0.0 6.9e-52 175.9 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EDN02150.1 - 6.2e-13 49.4 0.0 1.9e-12 47.8 0.0 1.9 2 1 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain DUF1010 PF06231.11 EDN02150.1 - 2.3 8.8 6.5 0.62 10.6 2.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1010) DUF4078 PF13300.6 EDN02151.1 - 8.6e-28 96.5 10.4 8.6e-28 96.5 10.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4078) TSP_NTD PF17804.1 EDN02151.1 - 2.3 8.5 6.4 2.7 8.2 1.1 2.2 2 0 0 2 2 2 0 Tail specific protease N-terminal domain ATG11 PF10377.9 EDN02152.1 - 6.4e-46 155.6 0.1 6.4e-46 155.6 0.1 3.1 3 0 0 3 3 3 1 Autophagy-related protein 11 APG17 PF04108.12 EDN02152.1 - 1.1e-06 28.1 10.6 2.2e-06 27.1 2.3 4.6 3 2 1 4 4 4 2 Autophagy protein Apg17 MscS_porin PF12795.7 EDN02152.1 - 0.0029 17.2 9.5 0.0029 17.2 9.5 5.9 5 2 1 6 6 6 1 Mechanosensitive ion channel porin domain Sas6_CC PF18594.1 EDN02152.1 - 0.34 10.7 9.8 0.075 12.8 0.6 3.5 3 0 0 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain DUF2972 PF11186.8 EDN02152.1 - 5.7 6.8 10.2 0.82 9.6 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2972) ApoO PF09769.9 EDN02152.1 - 8.5 6.4 16.3 6.4 6.7 0.2 4.9 5 0 0 5 5 5 0 Apolipoprotein O CENP-H PF05837.12 EDN02153.1 - 6.5e-20 71.6 9.6 1.1e-19 70.9 2.1 2.2 1 1 1 2 2 2 2 Centromere protein H (CENP-H) Ribosomal_L27_C PF18471.1 EDN02153.1 - 1.8 7.9 8.2 1.8 7.9 3.9 2.0 2 0 0 2 2 2 0 Ribosomal L27 protein C-terminal domain DUF4140 PF13600.6 EDN02153.1 - 8.5 6.9 10.2 9.5 6.7 3.9 2.7 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) HMG_box PF00505.19 EDN02154.1 - 2e-24 85.8 1.4 2e-24 85.8 1.4 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDN02154.1 - 1e-17 64.5 2.1 1e-17 64.5 2.1 1.5 2 0 0 2 2 2 1 HMG-box domain Ccdc124 PF06244.12 EDN02154.1 - 0.0023 18.5 0.1 0.0023 18.5 0.1 2.2 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box_5 PF14887.6 EDN02154.1 - 0.015 15.3 0.5 0.015 15.3 0.5 1.6 2 0 0 2 2 2 0 HMG (high mobility group) box 5 CHDNT PF08073.12 EDN02154.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain ABC2_membrane_2 PF12679.7 EDN02156.1 - 0.091 12.0 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein SKG6 PF08693.10 EDN02158.1 - 0.39 10.2 0.1 0.39 10.2 0.1 1.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Granulin PF00396.18 EDN02158.1 - 7.3 7.0 18.7 10 6.5 5.9 2.5 2 0 0 2 2 2 0 Granulin GMC_oxred_N PF00732.19 EDN02159.1 - 2.4e-32 112.5 0.0 3.5e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EDN02159.1 - 1.2e-06 27.8 0.4 1.7e-06 27.3 0.4 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EDN02159.1 - 1.5e-05 24.4 0.3 2.6e-05 23.6 0.3 1.4 1 0 0 1 1 1 1 Thi4 family GMC_oxred_C PF05199.13 EDN02159.1 - 4.2e-05 24.1 0.8 0.41 11.1 0.0 2.9 3 1 0 3 3 3 2 GMC oxidoreductase DAO PF01266.24 EDN02159.1 - 0.00019 21.2 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN02159.1 - 0.00033 20.0 0.1 0.00048 19.5 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN02159.1 - 0.00087 19.5 0.4 0.002 18.3 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EDN02159.1 - 0.0013 17.9 1.2 0.0019 17.3 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EDN02159.1 - 0.0069 15.3 0.4 0.01 14.7 0.4 1.2 1 0 0 1 1 1 1 Tryptophan halogenase HI0933_like PF03486.14 EDN02159.1 - 0.0091 14.7 0.6 0.014 14.2 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_9 PF13454.6 EDN02159.1 - 0.012 15.6 0.0 0.033 14.2 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.22 EDN02159.1 - 0.44 9.6 1.5 0.46 9.5 0.3 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A DnaJ PF00226.31 EDN02160.1 - 5.9e-09 35.9 1.7 1.3e-08 34.8 1.7 1.7 1 0 0 1 1 1 1 DnaJ domain Ubiq-assoc PF09145.10 EDN02161.1 - 0.074 13.1 0.0 0.074 13.1 0.0 1.0 1 0 0 1 1 1 0 Ubiquitin-associated ANXA2R PF15721.5 EDN02162.1 - 0.14 12.7 0.0 0.16 12.5 0.0 1.0 1 0 0 1 1 1 0 Annexin-2 receptor YbjQ_1 PF01906.17 EDN02163.1 - 0.0023 18.5 0.5 0.0034 18.0 0.5 1.4 1 0 0 1 1 1 1 Putative heavy-metal-binding LEA_4 PF02987.16 EDN02163.1 - 0.044 13.9 4.5 0.044 13.9 4.5 2.5 3 1 0 3 3 3 0 Late embryogenesis abundant protein YtxH PF12732.7 EDN02163.1 - 0.29 11.7 6.3 1.2 9.7 6.3 1.9 1 1 0 1 1 1 0 YtxH-like protein DUF883 PF05957.13 EDN02163.1 - 0.7 10.5 6.1 0.93 10.1 2.6 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) NB-ARC PF00931.22 EDN02164.1 - 1.4e-11 44.1 0.0 2.3e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EDN02164.1 - 4.7e-06 27.1 0.0 1.1e-05 25.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain PGAP1 PF07819.13 EDN02164.1 - 0.00059 19.6 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein NACHT PF05729.12 EDN02164.1 - 0.00089 19.2 0.0 0.0078 16.1 0.0 2.2 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 EDN02164.1 - 0.0014 18.6 0.0 0.0049 16.8 0.0 1.9 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Abhydrolase_6 PF12697.7 EDN02164.1 - 0.0047 17.6 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EDN02164.1 - 0.0077 15.8 0.1 0.022 14.3 0.1 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) ATPase PF06745.13 EDN02164.1 - 0.01 15.2 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.6 EDN02164.1 - 0.028 14.2 0.1 0.052 13.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EDN02164.1 - 0.038 13.7 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EDN02164.1 - 0.18 12.1 0.0 0.46 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ECH_1 PF00378.20 EDN02165.1 - 2.1e-43 148.5 0.0 4.6e-43 147.3 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN02165.1 - 2e-28 99.8 0.0 2.5e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pox_P21 PF05313.12 EDN02165.1 - 0.054 13.1 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P21 membrane protein tRNA_bind_2 PF13725.6 EDN02166.1 - 0.037 13.7 9.4 0.31 10.7 9.3 2.1 2 0 0 2 2 2 0 Possible tRNA binding domain GREB1 PF15782.5 EDN02166.1 - 1.3 6.1 7.6 1.9 5.5 7.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HTH_psq PF05225.16 EDN02167.1 - 0.022 14.5 0.1 0.037 13.8 0.1 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Phage_TAC_7 PF10109.9 EDN02168.1 - 0.066 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, E, or 41 or 14 Stm1_N PF09598.10 EDN02169.1 - 0.16 12.8 0.1 0.16 12.8 0.1 2.8 3 0 0 3 3 3 0 Stm1 DUF1786 PF08735.10 EDN02169.1 - 0.18 11.1 0.1 0.26 10.6 0.1 1.2 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) GatB_N PF02934.15 EDN02170.1 - 1.7e-37 129.3 0.0 2.2e-18 66.6 0.1 3.1 1 1 2 3 3 3 3 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EDN02170.1 - 3.8e-11 43.1 0.3 5.8e-11 42.5 0.3 1.3 1 0 0 1 1 1 1 GatB domain Arginase PF00491.21 EDN02171.1 - 9.9e-79 264.7 0.2 1.1e-78 264.5 0.2 1.0 1 0 0 1 1 1 1 Arginase family 7TMR-DISM_7TM PF07695.11 EDN02172.1 - 0.071 13.0 19.4 0.02 14.8 13.2 2.0 2 0 0 2 2 2 0 7TM diverse intracellular signalling Asp PF00026.23 EDN02173.1 - 1.6e-106 356.3 0.0 2e-106 356.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDN02173.1 - 7.1e-15 55.7 2.7 2.6e-13 50.6 1.0 2.9 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDN02173.1 - 0.00022 21.8 0.1 2.1 9.1 0.0 3.5 3 2 1 4 4 4 2 Aspartyl protease TAXi_C PF14541.6 EDN02173.1 - 0.0064 16.3 0.0 0.077 12.8 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EDN02173.1 - 0.0099 16.4 0.0 11 6.6 0.0 3.0 3 1 0 3 3 3 2 gag-polyprotein putative aspartyl protease NIF PF03031.18 EDN02174.1 - 2.5e-26 92.3 0.4 1.2e-25 90.1 0.0 2.0 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EDN02174.1 - 1.6e-09 38.0 0.5 7.7e-09 35.8 0.0 2.4 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDN02174.1 - 4.5e-07 30.2 0.1 8.8e-06 26.0 0.0 2.6 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EDN02174.1 - 6.8e-06 26.0 0.1 1.4e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 EDN02174.1 - 0.011 16.0 0.1 0.036 14.3 0.1 1.9 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EDN02174.1 - 0.1 12.5 2.3 0.1 12.5 0.0 2.2 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain AAA PF00004.29 EDN02175.1 - 9e-45 152.3 0.4 2.4e-44 151.0 0.0 1.9 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDN02175.1 - 1.8e-09 37.4 0.1 1.1e-08 34.9 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EDN02175.1 - 3.6e-08 33.5 0.1 1.2e-07 31.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDN02175.1 - 1.1e-07 32.1 0.0 2.3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDN02175.1 - 7.4e-07 29.7 0.1 0.00019 21.9 0.0 2.9 2 1 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EDN02175.1 - 3e-06 26.6 0.0 6.7e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDN02175.1 - 6.1e-05 23.3 1.3 0.015 15.5 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EDN02175.1 - 0.00037 20.2 0.0 0.00086 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EDN02175.1 - 0.0004 20.2 0.0 0.0011 18.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDN02175.1 - 0.00067 19.0 0.0 0.0012 18.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 EDN02175.1 - 0.00076 19.0 0.0 0.0064 16.0 0.1 2.3 2 1 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 EDN02175.1 - 0.00081 19.4 0.0 0.016 15.2 0.0 2.2 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDN02175.1 - 0.00085 19.9 0.0 0.0037 17.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDN02175.1 - 0.00094 19.5 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDN02175.1 - 0.0033 17.5 0.0 0.015 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDN02175.1 - 0.0038 17.6 0.0 0.0083 16.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.12 EDN02175.1 - 0.0067 16.4 0.2 0.11 12.4 0.1 2.5 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 EDN02175.1 - 0.0069 16.1 0.2 0.017 14.9 0.2 1.7 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDN02175.1 - 0.0099 15.3 0.1 0.022 14.1 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDN02175.1 - 0.011 15.5 0.0 0.061 13.0 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EDN02175.1 - 0.014 15.3 0.0 0.043 13.7 0.0 1.8 2 0 0 2 2 2 0 NTPase AAA_3 PF07726.11 EDN02175.1 - 0.014 15.2 0.1 0.05 13.5 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EDN02175.1 - 0.017 14.5 0.0 0.66 9.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_33 PF13671.6 EDN02175.1 - 0.023 14.8 0.0 0.051 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN02175.1 - 0.026 14.2 0.2 0.057 13.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EDN02175.1 - 0.05 12.9 1.0 0.6 9.4 0.0 2.4 3 0 0 3 3 3 0 KaiC Bac_DnaA PF00308.18 EDN02175.1 - 0.063 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 EDN02175.1 - 0.093 12.6 1.3 0.64 9.9 0.0 2.5 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EDN02175.1 - 0.1 12.3 0.1 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDN02175.1 - 0.11 12.0 0.9 0.51 9.9 0.1 2.2 2 1 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EDN02175.1 - 0.14 11.8 0.3 2.1 8.0 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EDN02175.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_29 PF13555.6 EDN02175.1 - 0.19 11.5 0.0 0.4 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PfkB PF00294.24 EDN02176.1 - 6.1e-16 58.6 0.0 4.7e-15 55.7 0.0 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase ARID PF01388.21 EDN02178.1 - 1.7e-13 51.0 0.1 3.8e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 EDN02178.1 - 0.051 12.9 0.1 0.12 11.7 0.1 1.6 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa RhlB PF12300.8 EDN02178.1 - 2.7 8.1 9.0 0.16 12.1 2.3 2.2 2 0 0 2 2 2 0 ATP-dependent RNA helicase RhlB Img2 PF05046.14 EDN02179.1 - 7.7e-25 87.0 0.0 1.3e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) eIF3_N PF09440.10 EDN02180.1 - 6.3e-52 175.5 4.9 1.7e-51 174.1 4.9 1.8 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EDN02180.1 - 3.7e-14 53.1 0.1 3.3e-13 50.0 0.0 2.5 2 0 0 2 2 2 1 PCI domain DUF249 PF03158.13 EDN02180.1 - 0.049 13.3 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Multigene family 530 protein DUF4951 PF16309.5 EDN02180.1 - 0.053 13.6 0.2 1.1 9.3 0.1 2.8 3 0 0 3 3 3 0 Domian of unknown function (DUF4951) SAP PF02037.27 EDN02182.1 - 0.0002 21.1 1.9 0.0002 21.1 1.9 1.9 3 0 0 3 3 3 1 SAP domain DDE_1 PF03184.19 EDN02183.1 - 9.6e-21 74.2 0.0 1.9e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN02183.1 - 7.9e-06 25.7 0.1 0.00062 19.5 0.0 3.1 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN02183.1 - 0.00081 19.4 0.3 0.0048 16.9 0.0 2.5 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN02183.1 - 0.02 14.6 0.5 0.02 14.6 0.5 2.3 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN02183.1 - 0.033 13.7 0.0 0.087 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) PV_NSP1 PF12433.8 EDN02183.1 - 0.11 12.9 0.1 8.9 6.7 0.0 2.6 2 0 0 2 2 2 0 Parvovirus non-structural protein 1 Borrelia_P83 PF05262.11 EDN02183.1 - 1.2 7.5 20.1 1.7 7.0 20.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein GBP_C PF02841.14 EDN02183.1 - 5 6.4 20.0 8.4 5.7 20.0 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain ArsA_ATPase PF02374.15 EDN02184.1 - 1.1e-113 379.5 0.0 1.3e-113 379.3 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EDN02184.1 - 1.5e-14 54.3 0.2 9e-13 48.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EDN02184.1 - 8.7e-13 48.4 0.0 1.5e-12 47.7 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EDN02184.1 - 2.5e-06 27.2 0.0 6e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EDN02184.1 - 1.2e-05 24.8 0.9 0.00012 21.6 0.1 2.3 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EDN02184.1 - 3e-05 23.8 0.4 0.00096 18.8 0.1 2.5 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EDN02184.1 - 7.3e-05 22.4 0.1 0.00026 20.6 0.0 1.8 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ PhoH PF02562.16 EDN02184.1 - 0.02 14.4 0.1 0.057 12.9 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 EDN02184.1 - 0.024 15.0 0.0 0.037 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EDN02184.1 - 0.034 13.3 0.0 0.073 12.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 EDN02184.1 - 0.036 13.6 0.1 0.16 11.6 0.1 1.9 2 0 0 2 2 2 0 AAA domain MipZ PF09140.11 EDN02184.1 - 0.21 10.9 0.2 0.83 8.9 0.1 2.0 3 0 0 3 3 3 0 ATPase MipZ ABC_tran_CTD PF16326.5 EDN02184.1 - 0.28 11.5 1.6 1.8 8.9 0.0 2.8 4 0 0 4 4 3 0 ABC transporter C-terminal domain Transthyretin PF00576.21 EDN02185.1 - 9.5e-26 90.6 0.0 9.1e-25 87.5 0.0 2.0 1 1 0 1 1 1 1 HIUase/Transthyretin family Mucin PF01456.17 EDN02185.1 - 0.018 15.0 14.3 0.025 14.5 14.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MSP1_C PF07462.11 EDN02185.1 - 8.1 5.0 4.9 9.2 4.8 4.9 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Aft1_HRA PF11786.8 EDN02186.1 - 4.5e-22 78.2 8.2 4.5e-22 78.2 8.2 2.7 1 1 1 2 2 2 1 Aft1 HRA domain Aft1_HRR PF11787.8 EDN02186.1 - 1.1e-20 74.6 3.3 1.1e-20 74.6 3.3 5.2 3 1 1 4 4 4 1 Aft1 HRR domain Aft1_OSA PF11785.8 EDN02186.1 - 3.6e-19 68.9 11.4 3.6e-19 68.9 11.4 3.4 4 1 0 4 4 4 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EDN02186.1 - 5.2e-12 45.7 5.8 9e-12 44.9 5.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDN02186.1 - 1.5e-06 28.2 5.6 1.5e-06 28.2 5.6 2.1 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDN02186.1 - 0.0024 18.4 3.8 0.0024 18.4 3.8 3.0 2 1 1 3 3 3 1 bZIP Maf transcription factor GCP_C_terminal PF04130.13 EDN02187.1 - 3.4e-101 338.8 0.0 5.6e-101 338.1 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EDN02187.1 - 2.1e-67 227.9 0.0 1.4e-66 225.2 0.0 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF2373 PF10180.9 EDN02188.1 - 1.5e-19 69.5 0.1 4.4e-19 68.1 0.1 1.8 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) Cecropin PF00272.19 EDN02188.1 - 1.9 8.3 7.2 0.81 9.5 2.3 2.5 2 0 0 2 2 2 0 Cecropin family Proteasome PF00227.26 EDN02189.1 - 6.2e-45 153.0 0.0 1.1e-40 139.2 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EDN02189.1 - 5.1e-12 45.2 0.4 1.1e-11 44.2 0.4 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Amidase_5 PF05382.13 EDN02189.1 - 0.1 12.5 0.0 2.9 7.8 0.0 2.2 2 0 0 2 2 2 0 Bacteriophage peptidoglycan hydrolase Ribosomal_L27e PF01777.18 EDN02191.1 - 3.4e-38 129.9 4.5 5e-38 129.3 4.5 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EDN02191.1 - 0.0014 18.5 0.5 0.0054 16.7 0.1 2.2 2 0 0 2 2 2 1 KOW motif MbeB_N PF04837.12 EDN02192.1 - 1.3 9.3 8.3 1 9.7 0.5 4.5 3 0 0 3 3 3 0 MbeB-like, N-term conserved region UBA_2 PF08587.11 EDN02192.1 - 4.6 7.4 15.0 35 4.6 0.0 7.1 7 1 1 8 8 8 0 Ubiquitin associated domain (UBA) DUF4435 PF14491.6 EDN02192.1 - 9.4 6.1 9.9 0.11 12.4 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4435) TRAM_LAG1_CLN8 PF03798.16 EDN02193.1 - 4.9e-51 173.3 18.6 7.1e-51 172.8 18.6 1.2 1 0 0 1 1 1 1 TLC domain PHD PF00628.29 EDN02194.1 - 6e-11 42.1 10.0 1.1e-10 41.3 10.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-RRPl_C4 PF17026.5 EDN02194.1 - 0.02 15.0 1.8 0.037 14.1 1.8 1.4 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type FYVE_2 PF02318.16 EDN02194.1 - 0.17 12.1 3.4 0.32 11.2 3.4 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger C1_1 PF00130.22 EDN02194.1 - 0.54 10.2 9.4 0.059 13.3 3.9 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EDN02194.1 - 0.72 9.5 6.9 0.21 11.2 2.7 2.2 2 0 0 2 2 2 0 PHD-finger Prok-RING_1 PF14446.6 EDN02194.1 - 1.8 8.5 11.9 0.048 13.6 5.1 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Anti-TRAP PF15777.5 EDN02194.1 - 4.9 7.2 9.0 1.3 9.1 0.4 2.9 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-B_box PF00643.24 EDN02194.1 - 6.3 7.0 9.2 17 5.6 0.1 2.8 2 1 0 2 2 2 0 B-box zinc finger Na_H_Exchanger PF00999.21 EDN02195.1 - 1.7e-30 106.1 33.1 3.7e-27 95.1 22.7 3.0 3 0 0 3 3 3 3 Sodium/hydrogen exchanger family Pex14_N PF04695.13 EDN02195.1 - 0.0045 17.7 2.9 5.7 7.6 3.4 2.7 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region CoA_transf_3 PF02515.17 EDN02196.1 - 5e-125 417.4 0.0 5.9e-125 417.2 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Lum_binding PF00677.17 EDN02197.1 - 2.3e-44 149.3 2.2 1.2e-21 76.4 0.7 2.2 2 0 0 2 2 2 2 Lumazine binding domain YabP PF07873.11 EDN02197.1 - 0.081 12.7 0.1 9 6.2 0.0 2.8 2 0 0 2 2 2 0 YabP family Brix PF04427.18 EDN02198.1 - 4.1e-44 151.0 0.8 5.6e-44 150.6 0.8 1.2 1 0 0 1 1 1 1 Brix domain FoP_duplication PF13865.6 EDN02198.1 - 0.028 15.0 10.9 0.086 13.4 10.9 1.8 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DEAD PF00270.29 EDN02199.1 - 3.9e-47 160.3 0.0 6.2e-47 159.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN02199.1 - 8.7e-31 106.5 0.1 1.5e-29 102.6 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN02199.1 - 5.3e-05 23.3 0.0 0.00011 22.2 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EDN02199.1 - 0.17 11.8 0.0 0.46 10.4 0.0 1.7 1 0 0 1 1 1 0 Flavivirus DEAD domain PGM_PMM_I PF02878.16 EDN02200.1 - 6e-16 58.4 0.0 1.4e-08 34.5 0.0 2.9 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EDN02200.1 - 2.9e-11 43.4 1.9 6.6e-11 42.2 0.7 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EDN02200.1 - 0.0014 19.2 0.2 0.0072 16.9 0.1 2.3 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EDN02200.1 - 0.0038 17.4 0.0 0.0076 16.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Per1 PF04080.13 EDN02201.1 - 1.6e-102 342.7 10.1 1.9e-102 342.4 10.1 1.1 1 0 0 1 1 1 1 Per1-like family Methyltransf_25 PF13649.6 EDN02202.1 - 1.9e-11 44.5 0.0 3.9e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDN02202.1 - 2.5e-11 43.5 0.0 4.5e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDN02202.1 - 1.7e-09 37.7 0.0 2.6e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN02202.1 - 3.3e-07 30.9 0.0 6.3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN02202.1 - 3e-06 27.2 0.0 4.5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EDN02202.1 - 7e-06 25.2 0.1 1.2e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EDN02202.1 - 5.5e-05 22.6 0.0 7.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EDN02202.1 - 0.00023 21.1 0.1 0.00039 20.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDN02202.1 - 0.00064 19.3 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EDN02202.1 - 0.0051 17.5 0.0 0.01 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EDN02202.1 - 0.0066 16.3 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 EDN02202.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 EDN02202.1 - 0.031 14.0 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EDN02202.1 - 0.053 13.3 0.1 0.083 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 EDN02202.1 - 0.17 11.5 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MaoC_dehydratas PF01575.19 EDN02203.1 - 2.8e-19 68.9 0.0 5.6e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EDN02203.1 - 1.4e-05 25.2 0.0 0.00037 20.6 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase TauD PF02668.16 EDN02204.1 - 1.1e-21 77.9 0.0 1.7e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EDN02204.1 - 0.13 12.9 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF971) AAA PF00004.29 EDN02205.1 - 2.5e-41 141.2 0.2 8.8e-41 139.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDN02205.1 - 7.1e-19 67.5 0.3 1.4e-18 66.6 0.3 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDN02205.1 - 3.2e-10 39.6 0.0 7.5e-10 38.5 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDN02205.1 - 1.2e-07 31.8 2.6 0.00022 21.3 0.1 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN02205.1 - 0.00014 22.3 1.3 0.02 15.3 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDN02205.1 - 0.00021 21.1 0.0 0.00056 19.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EDN02205.1 - 0.00063 19.0 1.2 0.018 14.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 EDN02205.1 - 0.0016 18.5 2.2 0.0048 17.0 0.0 2.8 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 EDN02205.1 - 0.0032 16.9 1.1 0.063 12.7 0.1 2.5 3 0 0 3 3 3 1 PhoH-like protein Mg_chelatase PF01078.21 EDN02205.1 - 0.008 15.6 0.1 0.023 14.1 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EDN02205.1 - 0.014 15.7 5.5 0.096 13.0 0.0 3.1 3 1 1 4 4 4 0 AAA domain AAA_33 PF13671.6 EDN02205.1 - 0.014 15.5 0.0 0.038 14.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDN02205.1 - 0.064 13.0 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EDN02205.1 - 0.07 12.6 0.3 0.49 9.9 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EDN02205.1 - 0.16 11.0 0.3 5.7 5.9 0.1 2.5 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EDN02205.1 - 0.32 10.8 0.0 0.32 10.8 0.0 2.9 2 1 1 3 3 2 0 AAA domain CLZ PF16526.5 EDN02205.1 - 0.32 11.4 9.8 0.063 13.6 5.0 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels F-box-like PF12937.7 EDN02206.1 - 0.0023 17.8 2.9 0.0067 16.3 1.2 2.7 2 1 0 2 2 2 1 F-box-like Pkinase PF00069.25 EDN02207.1 - 6.6e-70 235.5 0.0 8.8e-70 235.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02207.1 - 4.4e-32 111.4 0.0 6.6e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDN02207.1 - 1.1e-13 51.7 1.5 2.2e-13 50.7 0.1 2.4 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EDN02207.1 - 3.2e-09 36.5 0.1 1.4e-08 34.5 0.0 1.9 1 1 1 2 2 2 1 Kinase-like C2 PF00168.30 EDN02207.1 - 4.7e-08 33.2 0.0 2.6e-06 27.7 0.1 2.6 2 0 0 2 2 2 1 C2 domain Haspin_kinase PF12330.8 EDN02207.1 - 8.5e-05 21.7 0.3 0.00017 20.7 0.3 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDN02207.1 - 0.0033 17.4 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDN02207.1 - 0.012 15.2 1.1 1.8 8.2 0.1 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDN02207.1 - 0.068 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4246 PF14033.6 EDN02208.1 - 1.6e-171 571.4 0.3 2e-171 571.1 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EDN02208.1 - 0.011 16.2 0.0 0.033 14.6 0.0 1.8 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase CRC_subunit PF08624.10 EDN02209.1 - 6e-52 175.6 0.0 9.1e-52 175.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit TrkH PF02386.16 EDN02210.1 - 1.8e-47 162.0 2.1 6.2e-45 153.6 0.1 2.8 2 1 0 2 2 2 2 Cation transport protein Cyclin PF08613.11 EDN02211.1 - 4.1e-12 46.7 0.0 5.9e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EDN02211.1 - 0.00011 21.9 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF3915 PF13054.6 EDN02212.1 - 0.00084 19.3 2.5 0.00084 19.3 2.5 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 EDN02212.1 - 0.0021 16.5 9.5 0.0021 16.5 9.5 1.6 2 0 0 2 2 2 1 Atrophin-1 family Dor1 PF04124.12 EDN02213.1 - 3.7e-55 187.0 3.0 3.4e-49 167.4 2.6 2.5 1 1 1 2 2 2 2 Dor1-like family Vps51 PF08700.11 EDN02213.1 - 0.0022 18.0 0.2 0.0062 16.6 0.2 1.8 1 0 0 1 1 1 1 Vps51/Vps67 EAF PF09816.9 EDN02214.1 - 1.9e-21 76.3 0.4 7.6e-21 74.4 0.4 2.1 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Cyclin_N PF00134.23 EDN02214.1 - 6.8e-14 51.7 0.2 6.8e-14 51.7 0.2 2.2 3 0 0 3 3 3 1 Cyclin, N-terminal domain Mpp10 PF04006.12 EDN02214.1 - 0.002 16.7 27.7 0.002 16.7 27.7 2.8 4 0 0 4 4 4 1 Mpp10 protein Cyclin_C PF02984.19 EDN02214.1 - 0.0021 18.1 4.2 0.0026 17.8 0.1 2.8 3 0 0 3 3 3 1 Cyclin, C-terminal domain TFIIB PF00382.19 EDN02214.1 - 0.01 15.9 5.4 0.73 9.9 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat AAA_11 PF13086.6 EDN02214.1 - 4.9 6.9 17.3 0.23 11.2 11.2 1.9 2 0 0 2 2 2 0 AAA domain Methyltransf_23 PF13489.6 EDN02216.1 - 3.4e-42 144.1 0.0 4.5e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN02216.1 - 4.4e-08 33.7 0.0 1.2e-05 26.0 0.0 2.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN02216.1 - 9.5e-06 26.2 0.0 0.04 14.6 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDN02216.1 - 3e-05 24.7 0.0 0.011 16.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EDN02216.1 - 5.3e-05 23.1 0.0 0.051 13.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EDN02216.1 - 0.0058 16.0 0.0 0.17 11.2 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family DAO PF01266.24 EDN02217.1 - 2.7e-45 155.5 1.4 3.2e-45 155.2 1.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN02217.1 - 2.8e-09 36.6 0.2 0.0022 17.3 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN02217.1 - 1.3e-05 25.2 0.6 0.07 13.1 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.22 EDN02217.1 - 2.5e-05 23.5 0.1 0.0016 17.6 0.0 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 EDN02217.1 - 0.00026 20.0 0.1 0.1 11.4 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 EDN02217.1 - 0.00059 20.0 1.1 0.0012 19.0 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EDN02217.1 - 0.0014 17.7 0.2 0.058 12.4 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 EDN02217.1 - 0.0056 17.2 0.0 0.017 15.7 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDN02217.1 - 0.015 14.4 0.6 1.4 7.9 0.1 2.5 2 0 0 2 2 2 0 FAD binding domain TrkA_N PF02254.18 EDN02217.1 - 0.044 14.0 0.0 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_3 PF01494.19 EDN02217.1 - 0.064 12.5 0.0 0.78 8.9 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain TBP PF00352.21 EDN02218.1 - 3.3e-67 222.5 0.1 1e-32 111.9 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EDN02218.1 - 5e-05 23.3 0.0 0.2 11.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EDN02218.1 - 0.095 12.5 0.3 0.77 9.6 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) ETF_QO PF05187.13 EDN02221.1 - 3.1e-48 162.2 1.1 4.7e-48 161.6 1.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EDN02221.1 - 7.7e-08 32.3 0.3 0.0011 18.6 0.6 2.5 1 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDN02221.1 - 1.4e-07 30.9 0.2 0.0042 16.2 0.7 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EDN02221.1 - 6.5e-06 26.3 0.0 1.7e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDN02221.1 - 0.00014 21.2 0.0 0.00028 20.2 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDN02221.1 - 0.00044 19.7 0.0 0.00077 18.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDN02221.1 - 0.00044 19.1 0.6 0.0007 18.4 0.6 1.3 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EDN02221.1 - 0.0015 17.8 0.0 0.0085 15.4 0.1 1.9 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EDN02221.1 - 0.0018 18.8 0.0 4.4 7.9 0.0 2.8 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDN02221.1 - 0.0023 17.3 0.1 0.0037 16.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EDN02221.1 - 0.0039 16.5 0.7 0.0057 15.9 0.7 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDN02221.1 - 0.0063 15.4 0.1 0.092 11.6 0.2 2.2 1 1 1 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EDN02221.1 - 0.0082 16.1 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.7 EDN02221.1 - 0.045 14.3 1.6 0.079 13.6 0.6 1.9 2 0 0 2 2 1 0 4Fe-4S dicluster domain Lycopene_cycl PF05834.12 EDN02221.1 - 0.065 12.3 0.4 0.1 11.6 0.4 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Nitrate_red_gam PF02665.14 EDN02221.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Fer4_2 PF12797.7 EDN02221.1 - 0.15 12.3 0.7 0.4 10.9 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain GIDA PF01134.22 EDN02221.1 - 0.15 11.1 0.2 0.26 10.4 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A RRM_1 PF00076.22 EDN02222.1 - 1.6e-20 72.7 0.0 1.3e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN02222.1 - 0.011 15.6 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif Pkinase PF00069.25 EDN02223.1 - 8.2e-66 222.1 0.0 1.1e-65 221.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02223.1 - 1.1e-27 96.9 0.0 1.8e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FolB PF02152.18 EDN02223.1 - 4.1e-18 65.9 0.0 3.4e-13 50.1 0.1 2.6 2 0 0 2 2 2 2 Dihydroneopterin aldolase Pkinase_fungal PF17667.1 EDN02223.1 - 0.058 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EDN02223.1 - 0.083 11.8 0.1 0.17 10.8 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain ATG2_CAD PF13329.6 EDN02223.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif Pkinase_C PF00433.24 EDN02223.1 - 0.36 11.6 2.7 0.26 12.0 0.5 2.0 2 0 0 2 2 2 0 Protein kinase C terminal domain Ndc80_HEC PF03801.13 EDN02225.1 - 2.3e-62 209.1 0.2 6.7e-62 207.6 0.2 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family GAS PF13851.6 EDN02225.1 - 0.00091 18.6 15.8 0.00091 18.6 15.8 2.8 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EDN02225.1 - 0.011 15.9 7.7 0.011 15.9 7.7 3.9 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2780 PF11075.8 EDN02225.1 - 0.068 13.3 3.1 1.1 9.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function VcgC/VcgE (DUF2780) Spc7 PF08317.11 EDN02225.1 - 0.14 11.0 36.8 0.067 12.1 9.3 3.3 2 1 0 2 2 2 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 EDN02225.1 - 0.38 10.2 43.5 0.41 10.1 13.9 3.4 2 1 1 3 3 3 0 Golgin subfamily A member 5 Filament PF00038.21 EDN02225.1 - 0.63 9.6 42.6 3.1 7.3 14.6 2.8 2 1 0 2 2 2 0 Intermediate filament protein DUF16 PF01519.16 EDN02225.1 - 6.4 7.3 33.2 0.037 14.5 11.2 4.1 2 2 2 4 4 4 0 Protein of unknown function DUF16 Pex14_N PF04695.13 EDN02226.1 - 1.1e-39 136.7 11.1 7.3e-39 133.9 0.1 2.6 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1043 PF06295.12 EDN02226.1 - 0.0086 16.1 0.1 0.023 14.7 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) FlgN PF05130.12 EDN02226.1 - 0.018 15.6 0.5 0.018 15.6 0.5 1.6 2 0 0 2 2 2 0 FlgN protein TRAF_BIRC3_bd PF16673.5 EDN02226.1 - 0.1 12.4 0.1 15 5.5 0.2 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF3584 PF12128.8 EDN02226.1 - 0.11 10.0 2.7 0.15 9.5 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CdvA PF18822.1 EDN02226.1 - 0.16 11.8 2.9 2.3 8.1 0.7 2.3 1 1 1 2 2 2 0 CdvA-like coiled-coil domain DUF1664 PF07889.12 EDN02226.1 - 0.63 10.1 3.6 2 8.5 2.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 EDN02226.1 - 1.4 9.2 7.2 0.083 13.2 1.1 2.0 2 0 0 2 2 2 0 Zinc finger-containing protein DASH_Spc19 PF08287.11 EDN02226.1 - 5.9 6.8 9.6 0.57 10.1 4.5 1.9 2 1 0 2 2 2 0 Spc19 CCDC53 PF10152.9 EDN02226.1 - 8.2 6.8 9.0 1.2 9.5 3.3 2.4 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex ABC_tran PF00005.27 EDN02228.1 - 1.4e-36 126.0 0.0 4.2e-36 124.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EDN02228.1 - 5.6e-18 65.6 9.2 5.6e-18 65.6 9.2 1.7 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EDN02228.1 - 0.0009 18.7 0.0 0.0027 17.2 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 EDN02228.1 - 0.0027 17.0 0.0 0.0052 16.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin RsgA_GTPase PF03193.16 EDN02228.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 EDN02228.1 - 0.016 14.4 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 EDN02228.1 - 0.066 13.5 0.2 0.24 11.7 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EDN02228.1 - 0.074 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EDN02228.1 - 0.082 13.4 0.1 0.23 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EDN02228.1 - 0.1 12.4 0.3 0.45 10.3 0.0 2.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EDN02228.1 - 0.11 12.9 0.1 0.23 11.8 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain Seipin PF06775.14 EDN02229.1 - 3.1e-62 210.2 0.3 4.5e-62 209.7 0.3 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) TTL PF03133.15 EDN02229.1 - 5.8e-51 173.4 0.0 1.2e-50 172.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 EDN02229.1 - 4.1e-39 134.4 0.0 7.1e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 EDN02229.1 - 0.00021 20.6 0.0 0.00056 19.2 0.0 1.8 1 0 0 1 1 1 1 YheC/D like ATP-grasp Not1 PF04054.15 EDN02230.1 - 1.1e-139 465.5 2.3 1.8e-139 464.8 0.3 2.4 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EDN02230.1 - 4.9e-93 310.7 1.4 2.2e-92 308.5 1.4 2.2 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EDN02230.1 - 1.1e-51 174.6 2.7 2.7e-51 173.3 2.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EDN02230.1 - 8.4e-41 139.2 0.0 3.9e-40 137.0 0.0 2.1 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EDN02230.1 - 1.7e-33 115.9 0.3 1.7e-33 115.9 0.3 2.6 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat FCH PF00611.23 EDN02231.1 - 5e-15 55.5 0.3 2.6e-14 53.3 0.0 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Rapsyn_N PF10579.9 EDN02231.1 - 0.11 12.6 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region T7SS_ESX_EspC PF10824.8 EDN02231.1 - 0.2 12.1 1.5 39 4.8 0.1 3.2 3 0 0 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm DASH_Duo1 PF08651.10 EDN02233.1 - 4.5e-29 100.0 1.9 8.9e-29 99.1 1.9 1.5 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF745 PF05335.13 EDN02233.1 - 0.0061 16.3 4.9 0.011 15.4 4.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF745) DUF5568 PF17724.1 EDN02233.1 - 0.097 12.5 6.8 0.17 11.7 6.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5568) DASH_Dad2 PF08654.10 EDN02233.1 - 1.1 9.7 10.1 0.63 10.5 6.2 2.5 1 1 0 2 2 2 0 DASH complex subunit Dad2 zf-primase PF09329.11 EDN02235.1 - 1.3e-19 69.7 0.8 2.8e-19 68.7 0.8 1.6 1 0 0 1 1 1 1 Primase zinc finger RNase_H2-Ydr279 PF09468.10 EDN02236.1 - 3.3e-41 141.1 0.1 3.3e-41 141.1 0.1 2.3 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF1682 PF07946.14 EDN02236.1 - 0.0047 16.2 3.1 0.0047 16.2 3.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1682) Pex14_N PF04695.13 EDN02236.1 - 0.18 12.4 7.7 0.046 14.4 3.6 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GalKase_gal_bdg PF10509.9 EDN02237.1 - 5.1e-19 67.6 0.0 9e-19 66.8 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 EDN02237.1 - 1.1e-14 54.5 0.0 2.9e-14 53.2 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EDN02237.1 - 1.5e-12 47.5 1.6 3e-12 46.6 1.6 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain HTH_3 PF01381.22 EDN02237.1 - 0.043 13.9 0.1 1.4 9.0 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix Methyltransf_23 PF13489.6 EDN02238.1 - 2.4e-21 76.3 0.0 4.2e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN02238.1 - 1.8e-10 41.4 0.0 3.2e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN02238.1 - 1.2e-08 34.9 0.0 8.1e-08 32.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN02238.1 - 1.3e-08 35.4 0.0 7.4e-08 33.1 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN02238.1 - 3.8e-06 27.4 0.0 7.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EDN02238.1 - 0.001 18.6 0.0 0.02 14.4 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EDN02238.1 - 0.0051 16.4 0.0 0.014 15.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EDN02238.1 - 0.042 13.2 0.0 0.26 10.6 0.0 2.2 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EDN02238.1 - 0.11 12.2 0.1 1.7 8.3 0.1 2.1 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EDN02238.1 - 0.12 11.6 0.1 2.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase PS-DH PF14765.6 EDN02239.1 - 1.4e-53 182.1 0.0 2.3e-53 181.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EDN02239.1 - 8.7e-43 147.0 0.0 1.9e-42 145.9 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 EDN02239.1 - 4.7e-39 134.5 0.1 4.8e-28 98.4 0.0 2.5 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EDN02239.1 - 4.2e-36 123.6 0.0 4.2e-36 123.6 0.0 2.1 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EDN02239.1 - 1.3e-28 100.2 4.4 3.9e-25 88.8 0.1 2.8 1 1 1 2 2 2 2 KR domain Methyltransf_12 PF08242.12 EDN02239.1 - 3.7e-19 69.3 0.0 1.5e-18 67.3 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EDN02239.1 - 1.2e-17 64.2 0.0 6.8e-17 61.7 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EDN02239.1 - 1.2e-16 61.1 0.1 3.1e-11 43.7 0.0 2.7 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 EDN02239.1 - 1.1e-15 57.8 0.0 2.7e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EDN02239.1 - 2.2e-13 51.4 0.0 2.8e-11 44.6 0.0 3.4 2 1 1 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 EDN02239.1 - 1.1e-12 48.0 0.0 3.8e-12 46.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN02239.1 - 8.7e-11 42.4 0.0 4.2e-10 40.2 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN02239.1 - 2.3e-10 41.0 0.0 8.2e-10 39.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EDN02239.1 - 2.6e-06 27.3 0.4 6.7e-06 25.9 0.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EDN02239.1 - 0.00033 20.9 0.1 0.00086 19.6 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.18 EDN02239.1 - 0.00074 18.9 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 EDN02239.1 - 0.0078 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_28 PF02636.17 EDN02239.1 - 0.014 15.1 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_16 PF10294.9 EDN02239.1 - 0.1 12.4 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Lysine methyltransferase TPP_enzyme_N PF02776.18 EDN02240.1 - 8.1e-49 165.5 0.0 1.8e-48 164.4 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EDN02240.1 - 8.1e-49 165.3 0.3 1.1e-46 158.4 0.0 3.0 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDN02240.1 - 1.4e-40 138.2 0.4 2.6e-40 137.3 0.1 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 EDN02240.1 - 0.036 13.8 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg CO_dh PF02552.16 EDN02240.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit RINGv PF12906.7 EDN02241.1 - 3.2e-05 24.0 7.2 5.6e-05 23.2 7.2 1.4 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 EDN02241.1 - 0.00014 22.0 3.3 0.00026 21.1 3.3 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 EDN02241.1 - 0.13 12.6 6.7 0.26 11.7 6.7 1.5 1 0 0 1 1 1 0 Ring finger domain MRP-L28 PF09812.9 EDN02242.1 - 2.7e-05 24.4 0.0 3.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Ras PF00071.22 EDN02243.1 - 1.1e-46 158.4 0.0 1.3e-46 158.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN02243.1 - 2.3e-20 73.0 0.0 3.7e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN02243.1 - 5.4e-07 29.2 0.0 7.1e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDN02243.1 - 0.0025 17.3 0.0 0.004 16.6 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EDN02243.1 - 0.034 13.9 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EDN02243.1 - 0.044 13.9 0.0 0.08 13.0 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDN02243.1 - 0.068 12.5 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ADH_zinc_N PF00107.26 EDN02243.1 - 0.12 12.4 0.0 16 5.5 0.0 2.3 2 0 0 2 2 2 0 Zinc-binding dehydrogenase AAA_21 PF13304.6 EDN02243.1 - 0.23 11.2 0.1 0.28 11.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NST1 PF13945.6 EDN02244.1 - 3.1e-76 255.8 5.3 3.1e-76 255.8 5.3 3.3 2 1 1 3 3 3 1 Salt tolerance down-regulator CENP-B_dimeris PF09026.10 EDN02244.1 - 3.5 8.1 24.6 2.8 8.4 9.5 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Vps35 PF03635.17 EDN02247.1 - 0 1023.2 1.5 0 1023.0 1.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 DUF4746 PF15928.5 EDN02247.1 - 0.49 9.8 3.7 0.82 9.0 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Spore_coat_CotO PF14153.6 EDN02247.1 - 0.6 10.0 5.3 1.1 9.1 5.3 1.4 1 0 0 1 1 1 0 Spore coat protein CotO DUF1749 PF08538.10 EDN02249.1 - 1e-92 310.5 0.0 1.2e-92 310.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EDN02249.1 - 0.0011 18.3 0.0 0.0024 17.2 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDN02249.1 - 0.0028 18.3 0.0 0.0036 17.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EDN02249.1 - 0.021 14.7 0.0 0.46 10.3 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase PGAP1 PF07819.13 EDN02249.1 - 0.19 11.4 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Glycos_transf_2 PF00535.26 EDN02250.1 - 1.5e-33 116.0 0.0 1.8e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDN02250.1 - 1.6e-12 47.8 0.0 2.1e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EDN02250.1 - 2.6e-05 23.8 0.0 3.5e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDN02250.1 - 0.00078 19.0 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 TPR_19 PF14559.6 EDN02251.1 - 9.9e-07 29.2 1.9 0.043 14.3 0.2 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN02251.1 - 0.0057 16.9 5.5 0.018 15.3 1.7 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDN02251.1 - 0.0058 17.2 1.6 14 6.6 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF410 PF04190.13 EDN02251.1 - 0.015 15.1 0.2 0.16 11.8 0.0 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF410) TPR_16 PF13432.6 EDN02251.1 - 0.031 14.9 0.4 5.3 7.8 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EDN02251.1 - 0.11 12.2 0.9 0.6 9.8 0.2 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_2 PF07719.17 EDN02251.1 - 0.11 12.6 4.4 7.7 6.9 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 EDN02252.1 - 0.0021 18.1 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EDN02252.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 SAC3/GANP family HlyIII PF03006.20 EDN02253.1 - 4.4e-61 206.5 15.6 5e-61 206.3 15.6 1.0 1 0 0 1 1 1 1 Haemolysin-III related adh_short_C2 PF13561.6 EDN02254.1 - 2.4e-31 109.1 4.8 3.1e-18 66.2 0.1 3.0 1 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN02254.1 - 2.5e-26 92.4 3.8 8.2e-19 67.8 0.1 2.2 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDN02254.1 - 2.2e-05 24.4 0.6 0.01 15.8 0.0 2.2 1 1 0 2 2 2 2 KR domain AdoHcyase_NAD PF00670.21 EDN02254.1 - 0.026 14.6 0.6 0.066 13.3 0.6 1.6 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 EDN02254.1 - 0.15 11.9 0.1 0.22 11.4 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 EDN02255.1 - 9.2e-34 117.0 0.0 1.3e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02255.1 - 3e-20 72.6 0.0 4.2e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN02255.1 - 0.00093 19.2 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN02255.1 - 0.002 17.5 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDN02255.1 - 0.011 15.0 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDN02255.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 EDN02255.1 - 0.15 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF2301 PF10063.9 EDN02256.1 - 0.031 14.7 2.9 0.59 10.6 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized integral membrane protein (DUF2301) YrhK PF14145.6 EDN02256.1 - 1.3 9.0 28.7 11 6.0 8.8 4.8 2 2 1 3 3 3 0 YrhK-like protein Pkinase PF00069.25 EDN02257.1 - 2.9e-52 177.6 0.0 5.7e-52 176.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02257.1 - 6.7e-23 81.3 0.0 2e-22 79.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EDN02257.1 - 0.026 13.5 0.1 0.039 12.9 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 EDN02257.1 - 0.24 10.1 2.1 0.57 8.9 2.0 1.8 1 1 0 1 1 1 0 Fungal protein kinase TMA7 PF09072.10 EDN02258.1 - 7.7e-26 90.7 23.2 8.5e-26 90.6 23.2 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 DHR10 PF18595.1 EDN02259.1 - 1.6 8.8 5.2 2.8 8.0 5.2 1.3 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Cyt-b5 PF00173.28 EDN02260.1 - 2.9e-15 56.2 0.0 3.9e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4519 PF15012.6 EDN02260.1 - 0.17 12.1 0.2 0.32 11.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Ish1 PF10281.9 EDN02261.1 - 2.3e-73 242.2 17.1 2e-14 53.6 0.1 7.4 7 0 0 7 7 7 6 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EDN02261.1 - 1.6e-05 24.5 1.2 0.8 9.5 0.1 4.7 5 0 0 5 5 5 1 HeH/LEM domain SAP PF02037.27 EDN02261.1 - 0.00018 21.2 0.0 3.8 7.4 0.0 4.7 4 0 0 4 4 4 1 SAP domain Slx4 PF09494.10 EDN02261.1 - 0.00086 19.2 0.0 46 4.1 0.0 4.6 5 0 0 5 5 5 0 Slx4 endonuclease Endonuc-dimeris PF09124.10 EDN02261.1 - 0.0083 16.3 0.0 13 6.0 0.0 4.2 4 0 0 4 4 4 1 T4 recombination endonuclease VII, dimerisation Tir_receptor_M PF03549.14 EDN02261.1 - 0.039 14.3 0.0 3.1 8.2 0.0 3.3 3 0 0 3 3 3 0 Translocated intimin receptor (Tir) intimin-binding domain LEM PF03020.15 EDN02261.1 - 0.042 13.4 0.0 30 4.3 0.0 3.4 3 0 0 3 3 3 0 LEM domain ECM11 PF15463.6 EDN02261.1 - 0.08 13.5 0.9 0.27 11.8 0.2 2.3 2 0 0 2 2 2 0 Extracellular mutant protein 11 Thymopoietin PF08198.11 EDN02261.1 - 0.1 12.2 0.0 2.7 7.7 0.0 3.2 4 0 0 4 4 4 0 Thymopoietin protein Caudo_TAP PF02413.17 EDN02261.1 - 0.16 12.1 2.2 14 5.8 0.1 2.8 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK Rotamase_2 PF13145.6 EDN02261.1 - 1 10.2 5.4 6.1 7.7 0.4 4.0 2 1 1 3 3 3 0 PPIC-type PPIASE domain PQ-loop PF04193.14 EDN02262.1 - 1.1e-12 47.5 1.8 1.1e-12 47.5 1.8 2.8 3 1 1 4 4 4 1 PQ loop repeat ER_lumen_recept PF00810.18 EDN02262.1 - 0.065 14.1 4.2 0.12 13.2 4.2 1.4 1 0 0 1 1 1 0 ER lumen protein retaining receptor DUF1240 PF06836.12 EDN02262.1 - 0.6 10.7 4.7 0.09 13.3 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) 60KD_IMP PF02096.20 EDN02263.1 - 0.12 12.2 0.6 0.19 11.6 0.6 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein Pilin_N PF07790.11 EDN02264.1 - 0.032 15.2 1.3 0.076 14.0 1.3 1.6 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal Rick_17kDa_Anti PF05433.15 EDN02264.1 - 0.36 10.7 12.0 0.67 9.9 12.0 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EDN02264.1 - 0.42 10.7 9.3 0.81 9.7 9.3 1.4 1 0 0 1 1 1 0 Glycine zipper DUF3169 PF11368.8 EDN02264.1 - 0.43 10.1 1.6 0.59 9.6 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Gly-zipper_YMGG PF13441.6 EDN02264.1 - 1.1 9.1 9.3 2.2 8.1 9.3 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper SAM_MT PF04445.13 EDN02265.1 - 0.13 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Surp PF01805.20 EDN02266.1 - 1.3e-10 41.1 0.0 2.7e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Surp module CTD_bind PF04818.13 EDN02266.1 - 0.13 13.1 0.0 0.31 11.9 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase II-binding domain. TEX19 PF15553.6 EDN02266.1 - 1.2 9.1 4.7 3.5 7.6 0.9 2.8 2 1 0 2 2 2 0 Testis-expressed protein 19 NTF2 PF02136.20 EDN02267.1 - 2.9e-15 56.9 0.0 4.7e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Cg6151-P PF10233.9 EDN02268.1 - 8.3e-41 138.8 14.4 9.8e-41 138.6 14.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF2518 PF10726.9 EDN02268.1 - 2.5 7.7 7.6 0.8 9.4 4.1 1.8 1 1 1 2 2 2 0 Protein of function (DUF2518) WD40 PF00400.32 EDN02269.1 - 8.2e-49 162.6 27.9 9.7e-09 35.7 0.0 11.5 12 0 0 12 12 12 7 WD domain, G-beta repeat NACHT_N PF17100.5 EDN02269.1 - 6.9e-34 117.6 0.2 6.5e-33 114.4 0.1 2.2 2 0 0 2 2 2 1 N-terminal domain of NWD NACHT-NTPase ANAPC4_WD40 PF12894.7 EDN02269.1 - 9.8e-21 73.9 0.0 0.012 15.8 0.0 8.6 6 3 3 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EDN02269.1 - 8.4e-12 45.3 0.2 2.3e-11 43.9 0.2 1.7 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EDN02269.1 - 9.6e-10 37.9 0.3 0.3 10.0 0.0 6.3 4 2 3 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDN02269.1 - 3.6e-09 36.8 0.0 0.81 9.5 0.0 5.0 2 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EDN02269.1 - 5.3e-08 32.6 2.4 7.5 6.6 0.0 6.8 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EDN02269.1 - 7.9e-06 25.4 0.5 2.4 7.4 0.0 4.7 3 2 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal AAA_16 PF13191.6 EDN02269.1 - 1e-05 26.0 0.2 3.7e-05 24.2 0.2 2.0 1 0 0 1 1 1 1 AAA ATPase domain Nup160 PF11715.8 EDN02269.1 - 0.00078 18.2 1.2 1.6 7.3 0.0 4.4 4 1 1 5 5 5 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EDN02269.1 - 0.0044 15.6 0.0 10 4.6 0.0 3.6 3 1 0 3 3 3 1 Cytochrome D1 heme domain APS_kinase PF01583.20 EDN02269.1 - 0.021 14.7 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_22 PF13401.6 EDN02269.1 - 0.023 15.0 0.0 0.064 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDN02269.1 - 0.04 13.1 0.0 0.099 11.8 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 EDN02269.1 - 0.07 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN02269.1 - 0.083 13.3 0.0 0.34 11.3 0.0 2.1 1 0 0 1 1 1 0 RNA helicase RVT_1 PF00078.27 EDN02272.1 - 7.7e-19 68.1 0.1 1.5e-16 60.6 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN02272.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease Cytochrom_C550 PF14495.6 EDN02273.1 - 0.037 13.7 0.4 0.055 13.2 0.4 1.3 1 0 0 1 1 1 0 Cytochrome c-550 domain Glycos_transf_2 PF00535.26 EDN02273.1 - 0.057 13.2 0.2 0.093 12.5 0.1 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 2 zf-CCHC PF00098.23 EDN02273.1 - 0.11 12.6 6.3 0.2 11.8 6.3 1.4 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 EDN02274.1 - 1.7e-05 24.5 0.0 2e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EDN02275.1 - 7.5e-29 100.8 0.0 1.7e-28 99.6 0.0 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN02275.1 - 1e-07 32.2 0.2 3.3e-07 30.6 0.1 1.8 2 0 0 2 2 2 1 RNase H NAGidase PF07555.13 EDN02277.1 - 0.053 12.8 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase AAA PF00004.29 EDN02278.1 - 9.7e-15 55.2 0.0 1.4e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN02278.1 - 0.0022 18.4 0.2 0.061 13.7 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDN02278.1 - 0.0071 16.1 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EDN02278.1 - 0.051 13.1 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDN02278.1 - 0.12 12.7 0.2 2.4 8.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN02278.1 - 0.15 12.1 0.1 0.7 9.9 0.0 2.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) EAR PF07897.11 EDN02278.1 - 0.16 11.6 0.1 0.38 10.4 0.1 1.6 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression IBR PF01485.21 EDN02280.1 - 4.6e-08 33.2 21.1 2.7e-06 27.5 2.3 4.7 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain Chalcone_2 PF16035.5 EDN02281.1 - 1.5e-51 175.1 0.0 1.2e-50 172.2 0.0 1.9 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EDN02281.1 - 0.0045 17.1 0.1 0.013 15.6 0.1 1.7 1 1 0 1 1 1 1 Chalcone isomerase-like Glutaredoxin PF00462.24 EDN02282.1 - 1.4e-08 34.8 0.0 2e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF601 PF04642.12 EDN02283.1 - 0.011 15.3 0.6 0.012 15.1 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF601 VGCC_beta4Aa_N PF12052.8 EDN02283.1 - 0.048 13.8 5.9 0.095 12.8 5.9 1.6 1 1 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal MSP1a PF11670.8 EDN02284.1 - 0.76 9.0 2.8 1.7 7.9 2.8 1.5 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) LMBR1 PF04791.16 EDN02285.1 - 3.1e-64 217.8 0.0 5.4e-64 216.9 0.0 1.4 1 0 0 1 1 1 1 LMBR1-like membrane protein BAG PF02179.16 EDN02285.1 - 5.2e-16 58.8 0.3 1.1e-15 57.8 0.3 1.6 1 0 0 1 1 1 1 BAG domain NST1 PF13945.6 EDN02285.1 - 1.5 8.9 9.1 2.9 7.9 9.1 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator SRP-alpha_N PF04086.13 EDN02285.1 - 8 6.3 12.0 53 3.6 10.7 2.4 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal KIX_2 PF16987.5 EDN02287.1 - 1.4e-13 50.6 0.1 1.4e-12 47.4 0.1 2.9 1 0 0 1 1 1 1 KIX domain Bactofilin PF04519.13 EDN02287.1 - 0.39 11.0 2.7 0.74 10.1 2.7 1.4 1 0 0 1 1 1 0 Polymer-forming cytoskeletal K-box PF01486.17 EDN02288.1 - 0.016 15.4 0.4 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 K-box region DUF5102 PF17104.5 EDN02288.1 - 0.02 15.0 0.2 0.02 15.0 0.2 3.5 2 1 1 4 4 4 0 Domain of unknown function (DUF5102) zf-C2H2_aberr PF17017.5 EDN02288.1 - 0.24 11.5 0.1 0.36 10.9 0.1 1.2 1 0 0 1 1 1 0 Aberrant zinc-finger EamA PF00892.20 EDN02290.1 - 0.00032 20.9 3.4 0.00038 20.6 3.4 1.0 1 0 0 1 1 1 1 EamA-like transporter family MBOAT PF03062.19 EDN02291.1 - 7.2e-34 117.7 10.3 1.3e-33 116.8 10.3 1.4 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Adaptin_N PF01602.20 EDN02293.1 - 2.5e-103 346.4 1.9 3.5e-103 346.0 1.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EDN02293.1 - 1.2e-11 44.9 0.0 2.8e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EDN02293.1 - 0.00018 21.6 4.3 0.061 13.4 0.0 3.2 3 2 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN02293.1 - 0.00054 20.3 2.0 1.2 9.6 0.0 4.0 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EDN02293.1 - 0.043 14.1 1.6 45 4.7 0.1 3.8 3 0 0 3 3 3 0 HEAT repeat RICTOR_M PF14666.6 EDN02293.1 - 0.095 12.5 0.4 0.72 9.7 0.0 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain DUF563 PF04577.14 EDN02295.1 - 2e-43 149.0 0.0 3e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF347 PF03988.12 EDN02296.1 - 0.049 13.8 0.6 0.049 13.8 0.6 2.0 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) SKG6 PF08693.10 EDN02296.1 - 0.13 11.7 0.8 0.3 10.5 0.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DnaJ PF00226.31 EDN02297.1 - 1.5e-21 76.2 0.7 3.6e-21 75.0 0.7 1.7 1 0 0 1 1 1 1 DnaJ domain Ribosomal_L13 PF00572.18 EDN02300.1 - 1.9e-09 37.8 0.1 1.7e-05 25.1 0.0 2.7 1 1 2 3 3 3 2 Ribosomal protein L13 AMP-binding PF00501.28 EDN02301.1 - 3.9e-58 197.1 0.1 6.9e-40 136.9 0.0 2.0 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EDN02301.1 - 3.7e-09 37.4 0.1 8.1e-09 36.3 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain F-box-like PF12937.7 EDN02302.1 - 6.9e-11 41.9 0.8 6.9e-11 41.9 0.8 2.8 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EDN02302.1 - 1e-09 38.5 14.9 1.5 9.4 0.3 7.5 4 2 5 9 9 9 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDN02302.1 - 1.9e-09 36.8 29.0 0.87 9.8 0.0 11.4 12 0 0 12 12 12 4 Leucine Rich repeat F-box PF00646.33 EDN02302.1 - 2e-06 27.5 1.5 2e-06 27.5 1.5 2.5 2 0 0 2 2 2 1 F-box domain DUF1699 PF08004.11 EDN02302.1 - 0.0072 16.0 0.8 0.05 13.3 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1699) LRR_8 PF13855.6 EDN02302.1 - 0.014 15.2 7.3 4.2 7.2 0.5 5.1 4 2 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.33 EDN02302.1 - 0.23 12.2 15.9 2e+02 3.2 0.1 8.6 8 2 0 8 8 8 0 Leucine Rich Repeat TPR_1 PF00515.28 EDN02303.1 - 0.001 18.8 0.0 0.085 12.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN02303.1 - 0.015 16.0 0.4 0.046 14.4 0.4 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDN02303.1 - 0.021 15.0 0.0 3.5 8.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDN02303.1 - 0.026 14.6 0.0 0.42 10.8 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDN02303.1 - 0.029 14.4 0.3 0.084 12.9 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M28 PF04389.17 EDN02304.1 - 4.1e-17 62.5 0.0 9.9e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDN02304.1 - 0.032 13.9 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Med10 PF09748.9 EDN02305.1 - 3.5e-32 110.9 0.0 3.8e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 EDN02305.1 - 0.059 13.2 0.0 0.071 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) Ring_hydroxyl_B PF00866.18 EDN02305.1 - 0.15 12.1 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating beta subunit Pkinase PF00069.25 EDN02307.1 - 2.4e-39 135.3 0.0 3.5e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02307.1 - 4.4e-27 95.0 0.0 6.1e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN02307.1 - 0.002 17.5 0.0 0.0036 16.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF498 PF04430.14 EDN02307.1 - 0.16 12.0 0.2 0.34 11.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) MFS_1 PF07690.16 EDN02309.1 - 4.7e-22 78.4 11.4 5.3e-22 78.2 11.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EDN02309.1 - 0.0001 20.8 1.5 0.00014 20.3 1.5 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family TMEM237 PF15383.6 EDN02309.1 - 0.044 12.9 0.1 2.5 7.1 0.0 2.1 2 0 0 2 2 2 0 Transmembrane protein 237 HC2 PF07382.11 EDN02310.1 - 0.011 15.8 32.2 0.018 15.1 32.2 1.2 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 DUF1614 PF07758.11 EDN02310.1 - 0.06 13.4 1.3 0.086 12.8 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) TPR_1 PF00515.28 EDN02312.1 - 4.3e-30 102.3 9.8 3.2e-07 29.9 0.5 6.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDN02312.1 - 6.1e-29 97.8 8.1 4e-06 26.5 0.1 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat DnaJ PF00226.31 EDN02312.1 - 1.2e-27 95.8 6.5 3.3e-27 94.4 1.6 3.4 4 0 0 4 4 3 1 DnaJ domain TPR_19 PF14559.6 EDN02312.1 - 1.5e-23 83.1 7.5 3.2e-06 27.6 0.3 5.3 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDN02312.1 - 1.6e-18 65.3 8.1 0.0008 19.4 0.0 6.2 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDN02312.1 - 5.4e-18 64.1 5.4 2.1e-05 25.0 0.1 6.3 5 1 2 7 7 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN02312.1 - 2.8e-17 62.1 9.9 9.3e-06 25.2 0.0 6.0 5 2 2 7 7 7 4 TPR repeat TPR_7 PF13176.6 EDN02312.1 - 3.3e-16 58.1 4.2 0.0052 16.7 0.0 5.7 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDN02312.1 - 3.6e-16 59.5 0.6 2.4e-06 28.1 0.0 4.4 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN02312.1 - 1.5e-11 44.4 7.1 0.0012 19.1 0.7 4.7 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 EDN02312.1 - 2.1e-10 40.5 9.0 0.0033 18.0 0.1 6.6 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDN02312.1 - 1.6e-09 37.5 9.8 0.00052 20.2 0.5 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDN02312.1 - 2.8e-09 37.0 0.4 0.0036 17.4 0.1 3.6 3 1 1 4 4 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN02312.1 - 3.1e-07 30.5 2.3 0.0014 18.8 2.3 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EDN02312.1 - 1e-06 28.2 3.4 0.0042 16.4 0.0 4.5 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDN02312.1 - 3.7e-05 23.4 6.4 0.24 11.3 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EDN02312.1 - 0.00016 22.0 0.4 3.1 8.7 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDN02312.1 - 0.00086 19.3 3.5 1 9.5 0.1 3.8 1 1 2 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 EDN02312.1 - 0.0095 16.1 0.0 32 5.1 0.0 4.2 3 0 0 3 3 3 0 PPR repeat MIT PF04212.18 EDN02312.1 - 0.025 14.6 5.9 0.16 12.1 0.3 3.9 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_20 PF14561.6 EDN02312.1 - 0.033 14.5 5.9 1.8 9.0 0.2 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EDN02312.1 - 0.034 14.1 0.3 9.9 6.3 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDN02312.1 - 0.07 13.6 2.0 0.7 10.3 1.1 2.8 1 1 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_MalT PF17874.1 EDN02312.1 - 0.12 11.7 1.8 1.4 8.2 0.1 3.0 2 1 1 3 3 3 0 MalT-like TPR region RPT PF13446.6 EDN02312.1 - 0.36 10.8 2.2 2.4 8.2 0.0 3.1 4 1 0 4 4 3 0 A repeated domain in UCH-protein SPO22 PF08631.10 EDN02312.1 - 0.37 10.2 3.1 2.1 7.8 0.1 2.8 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like DUF4451 PF14616.6 EDN02313.1 - 1.2e-22 80.4 0.0 2.1e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Dynamin_N PF00350.23 EDN02314.1 - 7.9e-06 26.0 0.0 3.4e-05 24.0 0.0 2.2 1 0 0 1 1 1 1 Dynamin family DUF515 PF04415.12 EDN02315.1 - 2.6 6.3 3.9 3.5 5.9 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Vps54 PF07928.12 EDN02316.1 - 7.5e-38 130.0 0.0 1.3e-37 129.2 0.0 1.4 1 0 0 1 1 1 1 Vps54-like protein Pkinase PF00069.25 EDN02317.1 - 1.5e-25 90.1 0.0 1.9e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02317.1 - 5.3e-16 58.7 0.0 6.6e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Acyltransferase PF01553.21 EDN02318.1 - 0.09 12.4 0.0 0.093 12.4 0.0 1.1 1 0 0 1 1 1 0 Acyltransferase EHN PF06441.12 EDN02319.1 - 1.8e-31 108.7 0.4 2.4e-31 108.3 0.4 1.2 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EDN02319.1 - 0.00016 21.4 0.0 0.00026 20.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Sec39 PF08314.11 EDN02320.1 - 2.8e-237 789.9 0.0 2.9e-149 498.9 0.0 2.0 1 1 1 2 2 2 2 Secretory pathway protein Sec39 FAA_hydrolase PF01557.18 EDN02320.1 - 0.17 11.5 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Fumarylacetoacetate (FAA) hydrolase family Ndufs5 PF10200.9 EDN02321.1 - 0.00021 21.5 0.0 0.00027 21.1 0.0 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.8 EDN02321.1 - 0.0029 17.9 1.9 0.015 15.6 1.9 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3128) UPF0203 PF05254.12 EDN02321.1 - 0.0097 16.1 0.4 0.015 15.5 0.4 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX6B PF02297.17 EDN02321.1 - 0.032 14.5 0.2 0.045 14.0 0.2 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb DUF3535 PF12054.8 EDN02322.1 - 3.7e-130 435.1 0.1 3.2e-129 432.0 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) HEAT PF02985.22 EDN02322.1 - 2.6e-18 64.5 15.6 0.12 12.7 0.0 10.3 11 0 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.6 EDN02322.1 - 4e-09 36.7 11.8 0.018 15.4 0.0 7.6 9 0 0 9 9 9 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EDN02322.1 - 2.6e-07 31.1 0.1 0.11 13.1 0.0 4.4 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDN02322.1 - 1.7e-05 25.2 9.0 8.5 7.0 0.0 7.2 7 0 0 7 7 7 2 HEAT-like repeat TAF6_C PF07571.13 EDN02322.1 - 2.5e-05 24.5 1.6 0.23 11.8 0.0 5.7 5 1 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 EDN02322.1 - 6.9e-05 22.9 0.0 0.067 13.2 0.0 5.1 5 2 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDN02322.1 - 0.004 16.8 0.4 0.4 10.2 0.0 3.6 2 1 2 4 4 4 1 CLASP N terminal RTP1_C1 PF10363.9 EDN02322.1 - 0.1 12.8 0.0 4.3 7.6 0.0 3.7 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Helicase_C PF00271.31 EDN02323.1 - 4.9e-17 62.3 0.0 1.6e-16 60.7 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDN02323.1 - 0.0088 15.3 0.1 0.011 15.0 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SRP68 PF16969.5 EDN02324.1 - 0.032 13.3 1.8 0.044 12.8 1.8 1.1 1 0 0 1 1 1 0 RNA-binding signal recognition particle 68 Asp-B-Hydro_N PF05279.11 EDN02324.1 - 3.8 7.5 6.7 0.96 9.5 3.1 1.8 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Erythro_esteras PF05139.14 EDN02325.1 - 6.3e-96 322.2 1.7 1.3e-88 298.1 0.2 2.0 1 1 1 2 2 2 2 Erythromycin esterase Cofac_haem_bdg PF04187.13 EDN02325.1 - 0.024 14.6 0.2 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN Scs3p PF10261.9 EDN02327.1 - 6e-10 39.1 0.9 7.3e-10 38.8 0.9 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Glyco_hydro_3_C PF01915.22 EDN02329.1 - 3.3e-51 174.2 0.0 5.6e-51 173.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EDN02329.1 - 1.2e-37 130.0 0.0 2.2e-37 129.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Ret2_MD PF18528.1 EDN02330.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA editing 3' terminal uridylyl transferase 2 middle domain ClpB_D2-small PF10431.9 EDN02333.1 - 0.083 13.0 0.0 5 7.3 0.0 2.3 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein DUF5314 PF17241.2 EDN02337.1 - 0.0053 16.5 0.1 0.053 13.2 0.1 2.2 1 1 0 1 1 1 1 Family of unknown function (DUF5314) Retrotran_gag_2 PF14223.6 EDN02337.1 - 0.0087 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Fungal_trans PF04082.18 EDN02338.1 - 3.4e-22 78.7 0.0 4.7e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN02338.1 - 1.5e-09 37.9 11.7 2.6e-09 37.0 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.19 EDN02339.1 - 4.8 7.0 11.4 6.8 6.5 11.4 1.3 1 0 0 1 1 1 0 SPX domain CIMR PF00878.18 EDN02340.1 - 0.0016 18.5 0.1 0.01 15.9 0.0 2.2 2 1 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EDN02340.1 - 0.022 14.6 0.0 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Autophagy-related protein 27 ERG4_ERG24 PF01222.17 EDN02341.1 - 2.6e-12 46.3 0.0 2.9e-12 46.1 0.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family A_deamin PF02137.18 EDN02342.1 - 1.5e-11 44.3 0.1 1.8e-11 44.1 0.1 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain SF3b10 PF07189.11 EDN02343.1 - 1.6e-35 121.0 0.0 1.8e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Vir_act_alpha_C PF10400.9 EDN02345.1 - 0.17 12.6 6.0 0.098 13.3 3.6 1.8 1 1 1 2 2 2 0 Virulence activator alpha C-term DUF99 PF01949.16 EDN02345.1 - 0.76 9.2 2.9 1 8.8 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 OmpH PF03938.14 EDN02345.1 - 1.5 9.2 10.4 2 8.8 10.4 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4446 PF14584.6 EDN02345.1 - 3.2 7.7 6.0 4.1 7.4 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TMPIT PF07851.13 EDN02345.1 - 4.4 6.5 5.8 5.3 6.2 5.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein Tho2 PF11262.8 EDN02345.1 - 5.2 6.2 7.2 6.7 5.8 7.2 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 NT-C2 PF10358.9 EDN02346.1 - 3.4e-24 85.2 0.0 4.6e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins SLS PF14611.6 EDN02347.1 - 5.4e-36 124.5 0.0 8.4e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator TraE PF05309.11 EDN02348.1 - 0.062 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 TraE protein Myotub-related PF06602.14 EDN02349.1 - 5.3e-152 505.8 0.0 6.6e-152 505.5 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EDN02349.1 - 0.059 13.3 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 GRAM domain Y_phosphatase3 PF13350.6 EDN02349.1 - 0.12 12.3 0.2 0.5 10.3 0.0 2.0 2 0 0 2 2 2 0 Tyrosine phosphatase family Ribosomal_S3_C PF00189.20 EDN02350.1 - 1.7e-13 50.9 0.2 9.9e-13 48.4 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EDN02350.1 - 5.9e-12 45.2 0.1 9.5e-12 44.6 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 EDN02350.1 - 0.092 13.2 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 EDN02350.1 - 0.16 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Coilin N-terminus tRNA_synthFbeta PF17759.1 EDN02351.1 - 7.3e-48 162.8 0.0 1.1e-47 162.2 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EDN02351.1 - 1.7e-31 108.3 0.2 5e-31 106.8 0.1 1.9 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EDN02351.1 - 4.4e-25 88.4 0.1 9.3e-25 87.3 0.1 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EDN02351.1 - 7.2e-18 64.6 0.0 4.8e-15 55.6 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain HEAT_2 PF13646.6 EDN02352.1 - 7.9e-37 125.5 2.0 5.5e-11 42.7 0.0 8.0 3 2 5 8 8 8 7 HEAT repeats HEAT PF02985.22 EDN02352.1 - 4.4e-36 119.8 14.3 0.015 15.5 0.1 12.4 12 0 0 12 12 12 10 HEAT repeat HEAT_EZ PF13513.6 EDN02352.1 - 7.3e-12 45.5 7.0 0.013 16.0 0.0 8.0 8 2 2 10 10 10 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDN02352.1 - 3.7e-11 43.5 5.1 0.00097 19.7 0.1 6.9 5 2 3 8 8 8 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EDN02352.1 - 2.6e-08 34.1 9.9 0.0076 16.3 0.1 5.3 4 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDN02352.1 - 1.1e-06 27.6 3.3 0.018 13.6 0.1 4.1 3 1 2 5 5 5 2 Adaptin N terminal region RTP1_C1 PF10363.9 EDN02352.1 - 4.5e-05 23.6 3.9 1.3 9.3 0.1 4.3 3 1 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 EDN02352.1 - 0.00087 17.9 3.0 0.47 8.9 0.0 2.4 2 1 0 2 2 2 2 Proteasome non-ATPase 26S subunit CLASP_N PF12348.8 EDN02352.1 - 0.0029 17.2 1.6 1.3 8.5 0.2 4.3 3 2 2 5 5 5 1 CLASP N terminal TetR_C_16 PF17920.1 EDN02352.1 - 0.056 13.7 0.4 17 5.7 0.0 3.8 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Arm PF00514.23 EDN02352.1 - 0.058 13.4 5.5 2.7 8.1 0.0 5.1 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 EDN02352.1 - 0.12 11.4 0.2 1 8.4 0.0 2.6 2 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) M11L PF11099.8 EDN02352.1 - 0.13 12.5 0.2 32 4.8 0.0 3.3 2 1 1 3 3 3 0 Apoptosis regulator M11L like API5 PF05918.11 EDN02352.1 - 2.2 7.0 5.3 0.68 8.7 0.6 2.6 3 1 0 4 4 4 0 Apoptosis inhibitory protein 5 (API5) PI-PLC-X PF00388.19 EDN02353.1 - 1.1e-11 44.5 0.8 2e-11 43.7 0.8 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Glyco_transf_8 PF01501.20 EDN02353.1 - 0.00027 20.6 0.1 0.0005 19.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Prok-E2_E PF14462.6 EDN02353.1 - 0.73 9.7 2.1 3.2 7.6 0.2 2.6 3 0 0 3 3 3 0 Prokaryotic E2 family E Abhydrolase_1 PF00561.20 EDN02354.1 - 1.8e-14 54.0 0.0 1.3e-13 51.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN02354.1 - 2.6e-12 47.8 7.8 4.8e-12 47.0 7.8 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN02354.1 - 0.00019 20.8 0.0 0.00059 19.2 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 EDN02354.1 - 0.17 12.3 0.1 0.31 11.4 0.1 1.4 1 0 0 1 1 1 0 Epoxide hydrolase N terminus CENP-W PF15510.6 EDN02354.1 - 0.2 11.9 0.0 18 5.6 0.0 2.3 2 0 0 2 2 2 0 CENP-W protein Glyco_transf_90 PF05686.12 EDN02355.1 - 7.4e-13 48.2 15.2 3.7e-10 39.3 11.1 3.3 2 1 0 2 2 2 2 Glycosyl transferase family 90 CDO_I PF05995.12 EDN02356.1 - 5.5e-42 142.9 0.0 7.3e-42 142.5 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EDN02356.1 - 0.0021 17.6 0.0 0.0031 17.0 0.0 1.2 1 0 0 1 1 1 1 PCO_ADO MMR_HSR1_Xtn PF16897.5 EDN02357.1 - 3.1e-40 136.5 0.6 1.8e-39 134.0 0.2 2.3 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EDN02357.1 - 5.1e-13 48.9 0.0 1.2e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EDN02357.1 - 2.1e-09 37.4 0.0 6.7e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDN02357.1 - 0.023 14.8 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 Dynamin family RVT_2 PF07727.14 EDN02358.1 - 7.4e-49 166.6 0.0 3.5e-48 164.4 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN02358.1 - 1.5e-12 47.8 0.0 5.3e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN02358.1 - 6.2e-08 32.4 0.0 2.5e-07 30.4 0.0 2.1 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 EDN02358.1 - 0.053 13.3 0.0 0.24 11.2 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain RVT_3 PF13456.6 EDN02358.1 - 0.069 13.0 0.2 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase-like Qn_am_d_aIV PF09100.10 EDN02358.1 - 0.07 12.9 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV zf-CCHC PF00098.23 EDN02358.1 - 0.33 11.1 5.3 0.74 10.0 5.3 1.6 1 0 0 1 1 1 0 Zinc knuckle Ribosomal_L37 PF08561.10 EDN02361.1 - 2.4e-41 141.0 1.1 3e-41 140.7 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 DUF1996 PF09362.10 EDN02362.1 - 6.3e-85 284.9 0.3 8.6e-85 284.4 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) HECT_2 PF09814.9 EDN02363.1 - 2e-52 178.4 0.0 2.5e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding HECT_2 PF09814.9 EDN02364.1 - 9.7e-63 212.3 0.0 1.1e-62 212.0 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Headcase PF16002.5 EDN02364.1 - 0.045 13.2 0.2 0.092 12.2 0.2 1.4 1 0 0 1 1 1 0 Headcase protein zf-RING_12 PF17976.1 EDN02364.1 - 0.24 11.7 2.2 0.24 11.7 0.8 1.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Questin_oxidase PF14027.6 EDN02365.1 - 7.1e-92 308.6 2.9 8.8e-92 308.2 2.9 1.1 1 0 0 1 1 1 1 Questin oxidase-like DEAD PF00270.29 EDN02366.1 - 2e-09 37.5 0.0 6e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN02366.1 - 7.3e-05 22.8 0.0 0.00019 21.5 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN02366.1 - 0.039 14.2 0.2 0.16 12.3 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EDN02370.1 - 1.7e-49 167.6 0.0 7.3e-43 146.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN02370.1 - 4.7e-05 23.8 0.3 0.023 15.1 0.0 3.8 3 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDN02370.1 - 0.00011 21.9 0.0 0.00042 20.1 0.0 2.0 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 EDN02370.1 - 0.00051 19.2 0.0 0.00096 18.3 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_2 PF07724.14 EDN02370.1 - 0.0016 18.6 0.0 0.0044 17.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EDN02370.1 - 0.0021 18.4 0.0 0.015 15.6 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 EDN02370.1 - 0.0021 18.3 0.0 0.043 14.1 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_25 PF13481.6 EDN02370.1 - 0.0052 16.4 0.3 0.056 13.0 0.0 2.8 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 EDN02370.1 - 0.0064 15.7 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EDN02370.1 - 0.0084 15.9 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase PF06745.13 EDN02370.1 - 0.012 15.0 0.0 0.082 12.2 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 EDN02370.1 - 0.022 14.9 0.0 0.44 10.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.21 EDN02370.1 - 0.025 14.0 0.1 0.051 13.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_lid_3 PF17862.1 EDN02370.1 - 0.026 14.3 1.1 2.8 7.8 0.8 2.7 2 0 0 2 2 2 0 AAA+ lid domain AAA_7 PF12775.7 EDN02370.1 - 0.036 13.6 0.0 0.084 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EDN02370.1 - 0.039 14.5 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN02370.1 - 0.042 13.9 0.0 0.13 12.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EDN02370.1 - 0.051 13.6 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EDN02370.1 - 0.064 13.0 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 EDN02370.1 - 0.094 12.2 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EDN02370.1 - 0.11 12.7 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain SDA1 PF05285.12 EDN02371.1 - 0.042 13.3 5.6 0.044 13.2 5.6 1.1 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 EDN02371.1 - 0.081 12.8 5.1 0.11 12.3 5.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 EDN02371.1 - 0.098 10.9 2.8 0.096 11.0 2.8 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EDN02371.1 - 0.1 12.3 4.4 0.14 11.8 4.4 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EDN02371.1 - 0.3 10.4 9.2 0.37 10.1 9.2 1.1 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 EDN02371.1 - 0.38 10.1 7.5 0.51 9.7 7.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 EDN02371.1 - 0.42 9.8 4.3 0.52 9.5 4.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pox_Ag35 PF03286.14 EDN02371.1 - 0.99 9.2 8.6 1.2 8.9 8.6 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NESP55 PF06390.12 EDN02371.1 - 4.8 6.7 20.4 0.53 9.8 1.3 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) DNA_pol_phi PF04931.13 EDN02371.1 - 6.7 4.7 13.2 8 4.4 13.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi Sporozoite_P67 PF05642.11 EDN02371.1 - 6.9 4.6 8.0 9.2 4.2 8.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nucleo_P87 PF07267.11 EDN02371.1 - 7.1 5.4 8.0 9.2 5.0 8.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 HTH_7 PF02796.15 EDN02372.1 - 1.8e-07 31.1 0.0 5.1e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN02372.1 - 2.6e-06 27.1 0.0 0.00011 21.9 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN02372.1 - 5.7e-06 25.9 0.0 3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_29 PF13551.6 EDN02372.1 - 7.3e-06 25.9 0.0 5.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN02372.1 - 5.5e-05 22.9 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN02372.1 - 0.00088 19.2 0.0 0.0013 18.6 0.0 1.4 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN02372.1 - 0.023 15.3 0.0 1.2 9.8 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain GerE PF00196.19 EDN02372.1 - 0.036 13.6 0.5 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN02372.1 - 0.046 13.9 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN02372.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN02372.1 - 0.12 12.5 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein Peptidase_S9 PF00326.21 EDN02373.1 - 6.6e-41 140.1 0.0 8.8e-41 139.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EDN02373.1 - 0.0034 17.0 0.2 0.013 15.1 0.5 1.7 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EDN02373.1 - 0.014 14.9 0.2 0.032 13.8 0.2 1.6 1 1 0 1 1 1 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EDN02373.1 - 0.055 12.7 0.1 9.3 5.4 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF2920 PF11144.8 EDN02373.1 - 0.085 12.0 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) AXE1 PF05448.12 EDN02373.1 - 0.11 11.1 0.6 5.8 5.5 0.0 2.7 2 1 0 2 2 2 0 Acetyl xylan esterase (AXE1) PD40 PF07676.12 EDN02374.1 - 8.3e-06 25.6 0.7 0.0082 16.1 0.0 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Peptidase_S9_N PF02897.15 EDN02374.1 - 0.1 11.3 0.0 0.3 9.8 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain zf-C2H2 PF00096.26 EDN02375.1 - 9.5e-05 22.6 3.8 9.5e-05 22.6 3.8 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN02375.1 - 0.016 16.0 3.0 0.016 16.0 3.0 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger DUF3818 PF12825.7 EDN02376.1 - 8.1e-131 436.1 5.4 1.3e-130 435.3 5.4 1.4 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EDN02376.1 - 3.3e-40 137.1 0.7 6.1e-40 136.2 0.7 1.5 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EDN02376.1 - 2.5e-11 43.6 1.9 2e-10 40.6 0.0 3.3 3 1 0 3 3 3 1 PX domain Met_10 PF02475.16 EDN02379.1 - 2.2e-63 213.6 0.0 3.8e-63 212.8 0.0 1.4 1 1 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EDN02379.1 - 0.071 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase RNA_pol_Rpb4 PF03874.16 EDN02380.1 - 5.3e-22 78.4 3.4 7.6e-22 77.9 3.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 RhoGAP PF00620.27 EDN02381.1 - 1.1e-34 119.5 0.1 2.2e-34 118.5 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EDN02381.1 - 5e-28 97.1 34.5 1.6e-11 44.3 6.1 4.9 5 0 0 5 5 5 4 LIM domain TFIIA PF03153.13 EDN02381.1 - 4.3 7.2 17.9 7.5 6.4 17.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nbl1_Borealin_N PF10444.9 EDN02382.1 - 5.9e-21 73.9 1.9 9.2e-21 73.2 1.9 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 EDN02383.1 - 4.8e-16 59.3 0.0 1.1e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EDN02383.1 - 4.6e-06 27.0 0.1 7.1e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 EDN02383.1 - 0.0015 18.4 0.0 0.0023 17.8 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 EDN02383.1 - 0.016 15.1 0.3 0.041 13.8 0.3 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif Sybindin PF04099.12 EDN02384.1 - 6.6e-46 155.8 0.0 6.5e-31 107.2 0.0 2.2 1 1 1 2 2 2 2 Sybindin-like family Sedlin_N PF04628.13 EDN02384.1 - 5.6e-07 29.8 0.0 1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region bZIP_2 PF07716.15 EDN02384.1 - 0.0019 18.2 8.4 0.0036 17.4 8.4 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDN02384.1 - 0.011 15.9 9.1 0.011 15.9 9.1 1.7 1 1 1 2 2 2 0 bZIP transcription factor DUF745 PF05335.13 EDN02384.1 - 0.23 11.2 0.8 0.37 10.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF641 PF04859.12 EDN02384.1 - 0.65 10.3 2.0 1 9.7 2.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 EDN02384.1 - 4.8 6.2 8.5 3.8 6.5 6.9 1.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Methyltransf_31 PF13847.6 EDN02385.1 - 1.4e-20 73.6 0.0 2.9e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN02385.1 - 9.1e-16 58.4 0.0 2.5e-15 57.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN02385.1 - 1.1e-14 54.9 0.0 2.7e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN02385.1 - 2e-10 40.4 0.1 3.2e-10 39.7 0.1 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EDN02385.1 - 3.3e-10 40.1 0.0 7.1e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDN02385.1 - 2.1e-08 33.9 0.5 4.1e-08 33.0 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 EDN02385.1 - 2.3e-07 31.4 0.0 4.1e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDN02385.1 - 4.7e-05 23.2 0.0 7.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EDN02385.1 - 5.5e-05 22.8 0.1 9.3e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EDN02385.1 - 0.00049 19.5 0.0 0.00068 19.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 EDN02385.1 - 0.00095 19.2 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDN02385.1 - 0.0042 16.3 0.1 0.74 8.9 0.0 2.2 1 1 0 2 2 2 2 NNMT/PNMT/TEMT family Met_10 PF02475.16 EDN02385.1 - 0.039 13.7 0.1 0.072 12.8 0.1 1.4 1 0 0 1 1 1 0 Met-10+ like-protein FtsJ PF01728.19 EDN02385.1 - 0.046 13.8 0.0 0.087 12.9 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Fibrillarin PF01269.17 EDN02385.1 - 0.1 11.7 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Fibrillarin AA_permease_2 PF13520.6 EDN02386.1 - 3e-38 131.7 23.5 3.5e-20 72.2 16.0 2.7 1 1 1 2 2 2 2 Amino acid permease DDE_1 PF03184.19 EDN02387.1 - 4.3e-30 104.7 0.0 2.3e-29 102.3 0.0 2.2 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN02387.1 - 2e-07 30.9 0.0 6.6e-07 29.3 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN02387.1 - 7.1e-07 28.9 0.0 1.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN02387.1 - 0.00082 19.1 0.0 0.0093 15.7 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EDN02387.1 - 0.0019 17.9 9.8 0.0035 17.0 1.7 2.4 2 0 0 2 2 2 2 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EDN02387.1 - 0.037 13.9 0.4 0.32 10.8 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EDN02387.1 - 0.17 12.1 1.4 0.31 11.2 1.4 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN02387.1 - 0.37 10.5 4.0 0.1 12.4 0.5 1.8 2 0 0 2 2 2 0 Zinc knuckle NDC10_II PF16787.5 EDN02388.1 - 5.7e-25 88.0 0.0 6.3e-16 58.3 0.1 3.5 1 1 2 3 3 3 3 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN02388.1 - 4.1e-15 55.9 0.6 1.1e-14 54.5 0.1 2.0 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes DUF3716 PF12511.8 EDN02388.1 - 0.019 15.0 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Dot_icm_IcmQ PF09475.10 EDN02388.1 - 0.079 12.4 0.9 0.12 11.8 0.9 1.3 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) HTH_7 PF02796.15 EDN02389.1 - 1.5e-07 31.3 0.0 2.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN02389.1 - 1.5e-05 24.6 0.0 6.1e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EDN02389.1 - 1.8e-05 24.7 0.0 3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.18 EDN02389.1 - 0.00012 22.0 0.0 0.00015 21.7 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_38 PF13936.6 EDN02389.1 - 0.00018 21.2 0.1 0.00042 20.0 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 EDN02389.1 - 0.0075 16.9 0.0 0.67 10.6 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 EDN02389.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_33 PF13592.6 EDN02389.1 - 0.085 12.5 0.0 0.58 9.8 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix Terminase_5 PF06056.12 EDN02389.1 - 0.087 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN02389.1 - 0.093 12.9 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Trp repressor protein Nucleo_P87 PF07267.11 EDN02390.1 - 0.19 10.6 7.1 0.24 10.2 7.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NESP55 PF06390.12 EDN02390.1 - 0.55 9.8 22.0 0.17 11.4 3.0 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 EDN02390.1 - 3.6 7.6 25.2 0.071 13.1 3.5 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) bZIP_1 PF00170.21 EDN02391.1 - 0.00017 21.6 4.7 0.0003 20.8 4.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor BAG PF02179.16 EDN02391.1 - 0.14 12.6 0.4 0.32 11.5 0.1 1.7 1 1 1 2 2 2 0 BAG domain UQ_con PF00179.26 EDN02392.1 - 9.7e-24 83.6 0.0 2.4e-09 36.9 0.0 3.2 3 0 0 3 3 3 3 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN02392.1 - 0.0016 18.1 0.0 0.012 15.3 0.0 2.3 2 0 0 2 2 2 1 Prokaryotic E2 family B 3Beta_HSD PF01073.19 EDN02393.1 - 2.6e-46 157.9 0.0 1.3e-40 139.2 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDN02393.1 - 2.7e-20 72.9 0.0 1.8e-19 70.2 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDN02393.1 - 2.1e-14 53.7 0.0 1.5e-07 31.1 0.0 3.2 3 0 0 3 3 3 3 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDN02393.1 - 3.6e-12 46.0 0.0 9.7e-08 31.5 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EDN02393.1 - 1.5e-05 24.2 0.0 0.00041 19.5 0.0 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDN02393.1 - 0.00039 19.7 0.0 0.8 8.8 0.0 2.4 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Pkinase PF00069.25 EDN02394.1 - 6.3e-58 196.2 0.0 4e-38 131.3 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02394.1 - 6.1e-29 101.1 0.0 2.2e-20 73.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EDN02394.1 - 2.4e-11 43.8 0.0 4.5e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EDN02394.1 - 2.4e-06 27.1 0.0 8.1e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDN02394.1 - 0.00014 21.9 0.1 0.0043 17.0 0.2 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN02394.1 - 0.0029 17.0 0.0 0.0061 15.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.7 EDN02394.1 - 0.0029 17.8 0.0 0.0071 16.6 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EDN02394.1 - 0.0033 17.4 0.1 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 PAS fold Haspin_kinase PF12330.8 EDN02394.1 - 0.024 13.6 0.0 0.024 13.6 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 EDN02394.1 - 0.057 13.0 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PAS_4 PF08448.10 EDN02394.1 - 0.094 13.0 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 PAS fold Seadorna_VP7 PF07387.11 EDN02394.1 - 0.14 11.2 0.1 0.32 10.0 0.1 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 NARP1 PF12569.8 EDN02395.1 - 0.03 13.2 0.1 0.039 12.9 0.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDK2AP PF09806.9 EDN02395.1 - 0.13 12.3 0.4 0.18 11.8 0.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Myb_DNA-binding PF00249.31 EDN02396.1 - 0.0055 16.9 0.1 0.022 15.0 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain CCDC92 PF14916.6 EDN02396.1 - 0.57 10.0 3.1 4.9 7.0 0.3 2.4 1 1 1 2 2 2 0 Coiled-coil domain of unknown function Kdo PF06293.14 EDN02397.1 - 2e-05 24.0 0.0 4.2e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDN02397.1 - 0.00014 21.3 0.1 0.00029 20.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EDN02397.1 - 0.0049 15.7 0.0 0.01 14.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase HSDR_N_2 PF13588.6 EDN02397.1 - 0.011 15.7 0.0 0.71 9.9 0.0 2.4 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) APH PF01636.23 EDN02397.1 - 0.013 15.5 2.9 0.015 15.2 0.1 2.5 2 1 0 2 2 2 0 Phosphotransferase enzyme family RVT_1 PF00078.27 EDN02399.1 - 8.5e-38 130.1 0.0 1.5e-37 129.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN02399.1 - 1.2e-23 83.2 0.2 4.6e-23 81.3 0.2 2.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN02399.1 - 7e-12 45.7 0.0 1.6e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN02399.1 - 5.9e-07 29.3 0.2 1.1e-05 25.2 0.0 2.5 2 0 0 2 2 2 1 Reverse transcriptase-like Exo_endo_phos PF03372.23 EDN02399.1 - 5.7e-05 22.7 0.1 0.00016 21.3 0.1 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN02399.1 - 0.0064 16.5 4.0 0.018 15.1 4.0 1.9 1 0 0 1 1 1 1 Zinc knuckle PuR_N PF09182.10 EDN02399.1 - 0.0098 15.8 0.1 0.057 13.4 0.1 2.2 2 0 0 2 2 2 1 Bacterial purine repressor, N-terminal DUF3723 PF12520.8 EDN02401.1 - 2.2e-14 53.0 0.0 7.4e-13 48.0 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3723) DUF3435 PF11917.8 EDN02402.1 - 7.5e-147 489.6 4.3 1e-144 482.6 4.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN02402.1 - 0.011 15.6 0.0 0.4 10.5 0.0 2.5 2 0 0 2 2 2 0 Phage integrase family eIF-3_zeta PF05091.12 EDN02403.1 - 5.3e-206 685.6 0.0 6.4e-206 685.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3909 PF13077.6 EDN02403.1 - 0.071 13.3 0.7 3 8.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3909) Amidase PF01425.21 EDN02406.1 - 2.4e-90 303.7 0.0 3e-90 303.3 0.0 1.2 1 0 0 1 1 1 1 Amidase Secretin_N_2 PF07655.13 EDN02407.1 - 0.13 12.8 8.0 0.3 11.6 2.3 2.9 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3546 PF12066.8 EDN02408.1 - 4e-33 113.9 4.3 4e-33 113.9 4.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) DUF4187 PF13821.6 EDN02408.1 - 7.5e-13 48.0 0.2 1.6e-12 47.0 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.13 EDN02408.1 - 8.1e-11 42.7 0.2 8.1e-11 42.7 0.2 2.0 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF4890 PF16231.5 EDN02408.1 - 0.66 10.5 6.8 1.8 9.1 2.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4890) Glyco_transf_90 PF05686.12 EDN02409.1 - 2e-28 99.4 1.0 3e-28 98.8 1.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 EDN02409.1 - 0.0002 21.7 0.1 0.00042 20.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Cu-oxidase_3 PF07732.15 EDN02410.1 - 6e-10 39.2 0.3 3.1e-07 30.4 0.1 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDN02410.1 - 8.8e-10 38.5 0.2 0.0045 16.7 0.0 3.2 2 1 0 2 2 2 2 Multicopper oxidase Kinesin PF00225.23 EDN02411.1 - 1e-111 373.1 0.0 1.6e-111 372.5 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 EDN02411.1 - 8.7e-45 153.1 0.0 2.2e-44 151.8 0.0 1.8 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EDN02411.1 - 2.5e-38 132.0 11.1 2.5e-32 112.5 0.2 3.1 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.5 EDN02411.1 - 8e-24 84.3 0.0 2.1e-23 82.9 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 EDN02411.1 - 1.3e-07 32.0 0.2 6.2e-07 29.8 0.2 2.3 1 0 0 1 1 1 1 Kinesin protein 1B Exonuc_VII_L PF02601.15 EDN02411.1 - 0.036 13.6 0.2 0.036 13.6 0.2 2.4 2 1 0 2 2 2 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EDN02411.1 - 1.7 8.8 13.0 0.56 10.3 0.7 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Nexin_C PF08628.12 EDN02412.1 - 0.012 16.2 0.5 0.02 15.5 0.4 1.4 1 1 0 1 1 1 0 Sorting nexin C terminal RVT_1 PF00078.27 EDN02413.1 - 6.4e-26 91.2 0.0 1.1e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN02413.1 - 2.1e-11 43.7 0.0 6.7e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN02413.1 - 0.00039 20.6 0.0 0.00095 19.4 0.0 1.6 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN02413.1 - 0.052 14.0 0.8 0.21 12.0 0.5 2.2 2 0 0 2 2 2 0 ORF 12 gene product N-terminal Dehyd-heme_bind PF09098.10 EDN02414.1 - 0.076 12.6 0.0 0.32 10.6 0.0 2.0 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding STAG PF08514.11 EDN02415.1 - 0.094 12.6 4.1 0.12 12.3 4.1 1.3 1 0 0 1 1 1 0 STAG domain DUF658 PF04936.12 EDN02415.1 - 0.4 10.4 7.8 0.14 11.9 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF658) Peptidase_S49_N PF08496.10 EDN02415.1 - 1 9.4 7.7 1.2 9.2 7.7 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RT_RNaseH PF17917.1 EDN02416.1 - 2e-39 134.1 0.4 2e-39 134.1 0.4 2.4 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN02416.1 - 1.2e-34 118.3 0.0 3.9e-34 116.7 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN02416.1 - 5.4e-28 98.0 0.4 1.2e-27 96.9 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN02416.1 - 3.4e-19 68.7 0.1 7.8e-19 67.5 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN02416.1 - 2.1e-14 53.7 0.0 6.1e-14 52.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN02416.1 - 1e-12 47.8 0.2 2.8e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN02416.1 - 5.7e-06 26.4 0.1 2.3e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Tudor-knot PF11717.8 EDN02416.1 - 0.0055 16.6 0.2 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Asp_protease_2 PF13650.6 EDN02416.1 - 0.22 12.2 0.0 0.46 11.2 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease NDUFA12 PF05071.16 EDN02416.1 - 0.39 11.6 4.4 3.6 8.5 4.4 2.7 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 TSNAXIP1_N PF15739.5 EDN02416.1 - 3.3 8.1 10.6 0.86 10.0 0.5 3.2 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus Rieske PF00355.26 EDN02419.1 - 1.9e-17 63.0 0.0 4.5e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Ring_hydroxyl_A PF00848.19 EDN02419.1 - 2.3e-11 44.1 5.2 2.9e-07 30.7 0.0 2.4 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) AA_permease_2 PF13520.6 EDN02421.1 - 1.1e-62 212.3 50.9 1.3e-62 212.1 50.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDN02421.1 - 4.1e-24 85.0 41.2 5.5e-24 84.6 41.2 1.2 1 0 0 1 1 1 1 Amino acid permease Gram_pos_anchor PF00746.21 EDN02421.1 - 1 9.3 0.0 1 9.3 0.0 3.3 3 0 0 3 3 3 0 LPXTG cell wall anchor motif STIMATE PF12400.8 EDN02421.1 - 3.9 8.0 11.0 0.69 10.5 4.7 2.7 2 1 0 2 2 2 0 STIMATE family Fungal_trans_2 PF11951.8 EDN02422.1 - 1e-53 182.6 0.8 2.1e-53 181.5 0.8 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN02422.1 - 2.5e-05 24.3 3.3 6.3e-05 23.0 3.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain eIF3m_C_helix PF18005.1 EDN02422.1 - 3.4 7.4 6.0 6.9 6.5 6.0 1.5 1 0 0 1 1 1 0 eIF3 subunit M, C-terminal helix Sad1_UNC PF07738.13 EDN02423.1 - 8.9e-13 48.4 0.0 2.5e-05 24.3 0.0 2.3 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal GLYCAM-1 PF05242.11 EDN02423.1 - 0.088 12.9 0.6 0.3 11.2 0.6 1.9 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) WD40 PF00400.32 EDN02424.1 - 3.1e-30 103.7 7.8 5.3e-07 30.2 0.5 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 EDN02424.1 - 6.1e-09 35.1 0.4 0.096 11.3 0.2 5.0 4 1 1 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDN02424.1 - 1.9e-06 28.1 0.0 0.12 12.7 0.0 4.6 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3929 PF13066.6 EDN02424.1 - 0.071 13.2 0.0 3.1 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3929) DUF3883 PF13020.6 EDN02425.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) BCIP PF13862.6 EDN02427.1 - 5.1e-73 245.2 0.3 6.5e-73 244.9 0.3 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein RVT_1 PF00078.27 EDN02428.1 - 1.9e-40 138.7 0.0 3e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN02428.1 - 2e-13 50.2 0.0 6.2e-13 48.6 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN02428.1 - 0.00027 20.5 0.1 0.00052 19.6 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN02428.1 - 4.4 7.5 8.7 1.6 8.9 4.8 2.4 2 0 0 2 2 2 0 Zinc knuckle APH PF01636.23 EDN02429.1 - 4.6e-10 39.8 0.0 3.7e-09 36.9 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN02429.1 - 0.004 16.8 0.0 0.0059 16.2 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase zf-C2H2_2 PF12756.7 EDN02431.1 - 0.00075 19.8 0.5 0.65 10.4 0.0 2.2 1 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 EDN02431.1 - 0.002 18.4 5.2 0.011 16.2 0.3 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN02431.1 - 0.0049 17.6 6.9 0.49 11.4 0.2 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger Actin_micro PF17003.5 EDN02431.1 - 0.0066 15.7 0.1 0.035 13.3 0.0 1.7 1 1 1 2 2 2 1 Putative actin-like family zf-C2HE PF16278.5 EDN02431.1 - 0.01 16.3 1.6 0.3 11.6 0.2 2.3 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 EDN02431.1 - 0.013 15.9 7.3 1.2 9.8 0.1 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDN02431.1 - 0.23 11.8 3.9 44 4.5 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDN02431.1 - 5.3 7.2 10.4 4.7 7.3 0.8 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Kdo PF06293.14 EDN02433.1 - 0.00054 19.4 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDN02433.1 - 0.039 13.3 0.0 0.047 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain NmrA PF05368.13 EDN02436.1 - 0.12 11.9 0.1 0.19 11.3 0.1 1.6 1 1 0 1 1 1 0 NmrA-like family Rrp15p PF07890.12 EDN02438.1 - 0.066 13.6 0.3 3 8.2 0.0 2.8 3 0 0 3 3 3 0 Rrp15p BCS1_N PF08740.11 EDN02439.1 - 2.9e-11 43.7 0.1 3.3e-11 43.5 0.1 1.1 1 0 0 1 1 1 1 BCS1 N terminal Bac_export_2 PF01312.19 EDN02439.1 - 0.012 14.8 0.1 0.014 14.7 0.1 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Fanconi_A_N PF15865.5 EDN02439.1 - 0.019 14.4 0.1 0.023 14.1 0.1 1.1 1 0 0 1 1 1 0 Fanconi anaemia group A protein N terminus Aa_trans PF01490.18 EDN02444.1 - 4.8e-27 94.7 31.9 5.9e-27 94.4 31.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 EDN02444.1 - 0.073 11.9 47.3 10 4.8 47.2 2.2 1 1 0 1 1 1 0 Amino acid permease 7TM_GPCR_Sru PF10322.9 EDN02445.1 - 5.1 6.3 19.0 0.026 13.9 1.4 2.6 2 1 1 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Sru Hydantoinase_B PF02538.14 EDN02446.1 - 7.5e-129 430.5 0.0 1e-128 430.0 0.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EDN02446.1 - 2.3e-88 296.2 5.2 5e-88 295.1 2.2 2.2 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDN02446.1 - 1.2e-44 152.2 0.9 3.1e-42 144.3 0.0 2.6 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EDN02446.1 - 2.2e-05 23.3 0.8 0.032 12.8 0.1 2.3 2 0 0 2 2 2 2 MutL protein FtsA PF14450.6 EDN02446.1 - 0.0036 17.7 1.3 1.2 9.6 0.1 2.9 2 0 0 2 2 2 2 Cell division protein FtsA Rop-like PF05082.13 EDN02446.1 - 0.081 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Rop-like BcrAD_BadFG PF01869.20 EDN02446.1 - 0.18 11.3 0.8 0.54 9.7 0.1 2.0 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family TPX2_importin PF12214.8 EDN02448.1 - 0.11 12.7 0.1 0.15 12.3 0.1 1.2 1 0 0 1 1 1 0 Cell cycle regulated microtubule associated protein DDE_Tnp_1_7 PF13843.6 EDN02451.1 - 0.005 16.2 0.1 0.005 16.2 0.1 1.2 1 0 0 1 1 1 1 Transposase IS4 Kinesin PF00225.23 EDN02453.1 - 1.2e-80 271.0 0.1 1.2e-80 271.0 0.1 3.8 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EDN02453.1 - 1.2e-18 67.5 0.0 1.2e-17 64.3 0.0 2.9 1 1 0 1 1 1 1 Microtubule binding SLATT_5 PF18160.1 EDN02453.1 - 0.77 9.1 6.6 0.4 10.0 0.0 3.7 3 1 1 4 4 4 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF2997 PF11211.8 EDN02453.1 - 1.6 8.5 3.7 28 4.6 0.1 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2997) Glycos_transf_1 PF00534.20 EDN02454.1 - 2e-29 102.3 0.7 1.9e-28 99.2 0.7 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDN02454.1 - 2.2e-16 60.3 0.1 1.9e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EDN02454.1 - 1.2e-11 45.2 0.1 5.4e-11 43.1 0.0 2.1 1 1 1 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EDN02454.1 - 2.4e-07 31.3 0.5 1e-06 29.3 0.5 2.0 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EDN02454.1 - 0.037 14.4 0.0 0.07 13.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF4611 PF15387.6 EDN02454.1 - 0.039 14.2 0.1 0.077 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Glyco_trans_4_5 PF16994.5 EDN02454.1 - 0.14 11.8 0.0 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Glycosyl-transferase family 4 ALG11_N PF15924.5 EDN02454.1 - 0.22 11.6 0.0 6.4 6.8 0.0 2.5 3 0 0 3 3 3 0 ALG11 mannosyltransferase N-terminus Peptidase_M16_M PF16187.5 EDN02457.1 - 7.3e-96 320.7 0.3 1.8e-95 319.5 0.0 1.8 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EDN02457.1 - 8.1e-35 120.5 0.0 4.5e-22 78.9 0.0 4.4 5 0 0 5 5 5 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDN02457.1 - 1.9e-29 102.6 5.6 1.3e-21 77.2 0.9 3.4 3 0 0 3 3 3 2 Insulinase (Peptidase family M16) Poxvirus PF06227.12 EDN02457.1 - 0.6 9.9 3.4 3.1 7.6 0.0 2.9 3 0 0 3 3 3 0 dsDNA Poxvirus DBR1 PF05011.13 EDN02458.1 - 2.7e-43 147.7 0.4 7.5e-43 146.3 0.0 2.0 2 0 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain APC_u13 PF16634.5 EDN02458.1 - 0.056 13.4 2.0 0.14 12.1 1.7 2.0 1 1 0 1 1 1 0 Unstructured region on APC between APC_crr and SAMP RTP1_C1 PF10363.9 EDN02459.1 - 7e-31 106.7 1.8 1.4e-29 102.5 0.1 3.6 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EDN02459.1 - 1.7e-09 37.2 0.0 4.1e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 Polysacc_deac_1 PF01522.21 EDN02460.1 - 1e-27 96.5 0.0 1.6e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase HMG14_17 PF01101.18 EDN02462.1 - 0.7 10.9 6.5 2 9.4 6.5 1.8 1 0 0 1 1 1 0 HMG14 and HMG17 Clathrin PF00637.20 EDN02463.1 - 5.3e-22 78.2 5.8 1.1e-19 70.8 3.5 2.6 2 0 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 EDN02463.1 - 4e-07 29.8 8.5 9.3e-07 28.6 8.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 EDN02463.1 - 3.9e-05 23.6 9.1 7.5e-05 22.7 9.1 1.5 1 0 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 EDN02463.1 - 5.6e-05 23.0 7.2 0.00012 22.0 7.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EDN02463.1 - 0.00025 21.3 8.8 0.00048 20.4 8.8 1.5 1 0 0 1 1 1 1 Ring finger domain VPS11_C PF12451.8 EDN02463.1 - 0.0016 18.6 0.3 0.0035 17.5 0.3 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal TPR_11 PF13414.6 EDN02463.1 - 0.002 17.8 0.4 0.002 17.8 0.4 2.2 2 0 0 2 2 1 1 TPR repeat TPR_14 PF13428.6 EDN02463.1 - 0.013 16.3 0.3 1.8 9.6 0.0 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat zf-rbx1 PF12678.7 EDN02463.1 - 0.013 15.7 6.3 0.028 14.7 6.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain TPR_12 PF13424.6 EDN02463.1 - 0.016 15.5 2.7 0.11 12.8 0.3 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Vps39_2 PF10367.9 EDN02463.1 - 0.018 15.4 0.6 0.018 15.4 0.6 3.2 3 1 1 4 4 2 0 Vacuolar sorting protein 39 domain 2 WD40_like PF17005.5 EDN02463.1 - 0.045 13.1 0.4 0.12 11.6 0.3 1.7 2 0 0 2 2 2 0 WD40-like domain DUF2383 PF09537.10 EDN02463.1 - 0.12 12.8 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) zf-ANAPC11 PF12861.7 EDN02463.1 - 0.12 12.4 1.1 0.4 10.8 1.1 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EDN02463.1 - 0.14 12.2 7.3 0.43 10.6 7.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EDN02463.1 - 0.14 12.0 7.4 0.29 11.1 7.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EDN02463.1 - 0.18 11.7 1.3 0.46 10.4 1.3 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 EDN02463.1 - 0.33 10.8 5.7 0.65 9.9 5.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 EDN02463.1 - 0.36 11.1 6.4 0.22 11.7 0.2 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-C3HC4_4 PF15227.6 EDN02463.1 - 3.2 8.0 5.5 7.9 6.7 5.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING TPR_1 PF00515.28 EDN02463.1 - 5 7.1 5.9 5.4 7.0 0.4 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat LRR_4 PF12799.7 EDN02464.1 - 1.5e-25 88.8 31.1 2.8e-06 27.6 0.9 8.3 4 2 6 10 10 10 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDN02464.1 - 2.5e-23 81.6 28.5 1.3e-06 28.0 0.5 7.0 5 1 0 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 EDN02464.1 - 2e-08 33.9 9.0 1.3e-05 24.8 1.8 4.2 1 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 EDN02464.1 - 0.0055 16.7 23.8 1.1 9.5 0.1 9.7 11 0 0 11 11 11 2 Leucine Rich repeat LRR_1 PF00560.33 EDN02464.1 - 0.0078 16.6 30.1 13 6.8 0.0 11.1 9 1 0 9 9 9 1 Leucine Rich Repeat IPK PF03770.16 EDN02465.1 - 3.9e-57 193.3 0.0 6.2e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase Pam17 PF08566.10 EDN02465.1 - 0.055 13.3 0.1 0.16 11.8 0.1 1.8 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 MFS_1 PF07690.16 EDN02466.1 - 4.7e-17 62.0 15.4 9.2e-17 61.0 15.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EDN02466.1 - 2.3e-06 27.3 1.9 2.3e-06 27.3 1.9 2.2 2 0 0 2 2 2 1 Nodulin-like BT1 PF03092.16 EDN02466.1 - 0.057 11.6 0.1 0.089 11.0 0.1 1.2 1 0 0 1 1 1 0 BT1 family STG PF15809.5 EDN02466.1 - 0.18 11.8 2.5 0.41 10.7 2.5 1.5 1 1 0 1 1 1 0 Simian taste bud-specific gene product family ERCC4 PF02732.15 EDN02467.1 - 2.6e-27 96.0 0.2 1.7e-22 80.3 0.1 2.6 1 1 1 2 2 2 2 ERCC4 domain DUF4355 PF14265.6 EDN02467.1 - 0.023 15.0 11.4 0.043 14.0 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Tho2 PF11262.8 EDN02467.1 - 5.5 6.1 7.0 10 5.2 7.0 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF1682 PF07946.14 EDN02467.1 - 8.3 5.5 17.0 12 4.9 17.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RT_RNaseH PF17917.1 EDN02469.1 - 1.7e-34 118.3 0.0 7e-34 116.3 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN02469.1 - 3.2e-33 115.1 0.1 5.4e-33 114.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN02469.1 - 1.3e-23 82.9 0.1 1.8e-12 47.1 0.0 2.9 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN02469.1 - 3.2e-19 68.8 0.2 8.1e-19 67.5 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN02469.1 - 7.2e-14 51.4 1.5 2.1e-13 50.0 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN02469.1 - 1.1e-12 48.1 0.0 3.6e-12 46.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN02469.1 - 1.8e-05 24.8 0.1 4e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN02469.1 - 0.048 13.8 0.8 0.36 11.0 0.2 2.4 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 PSII_Pbs27 PF13326.6 EDN02469.1 - 0.14 12.5 0.0 0.79 10.0 0.0 2.2 2 0 0 2 2 2 0 Photosystem II Pbs27 Retrotran_gag_2 PF14223.6 EDN02469.1 - 0.36 10.5 1.6 0.9 9.2 1.6 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Tmemb_9 PF05434.11 EDN02470.1 - 0.0084 16.0 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 1 TMEM9 RT_RNaseH_2 PF17919.1 EDN02471.1 - 0.0063 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase GerA PF03323.13 EDN02471.1 - 0.051 12.0 0.2 0.074 11.5 0.2 1.2 1 1 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein NUDIX_2 PF13869.6 EDN02473.1 - 7.6e-82 273.5 0.0 9.1e-82 273.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase zf-CHCC PF10276.9 EDN02474.1 - 4e-15 55.6 2.2 4e-15 55.6 2.2 2.1 2 0 0 2 2 2 1 Zinc-finger domain CoaE PF01121.20 EDN02475.1 - 1.6e-40 138.7 0.0 4.8e-21 75.2 0.0 2.1 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_33 PF13671.6 EDN02475.1 - 0.00052 20.2 0.1 0.0086 16.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain TPR_10 PF13374.6 EDN02475.1 - 0.073 13.0 0.5 0.29 11.1 0.5 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_18 PF13238.6 EDN02475.1 - 0.1 13.2 0.0 0.44 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF393 PF04134.12 EDN02475.1 - 1.9 9.8 6.1 0.16 13.3 1.5 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF393 DUF3431 PF11913.8 EDN02476.1 - 2.6e-89 298.7 1.1 8.9e-89 296.9 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3431) ECH_1 PF00378.20 EDN02477.1 - 1.2e-48 165.6 0.0 3.4e-48 164.2 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN02477.1 - 1.3e-23 84.1 0.1 7.7e-21 74.9 0.0 2.5 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase LPD15 PF18828.1 EDN02477.1 - 0.17 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 FMO-like PF00743.19 EDN02478.1 - 2.4e-16 59.3 0.1 2.3e-15 56.1 0.1 2.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EDN02478.1 - 5.6e-07 29.7 0.3 2.7e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EDN02478.1 - 9.1e-07 28.3 0.0 0.00031 20.0 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EDN02478.1 - 5.4e-06 25.9 0.0 6.9e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN02478.1 - 1e-05 25.0 0.0 0.0006 19.1 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN02478.1 - 0.004 17.2 0.1 0.18 11.8 0.0 3.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding Fungal_trans PF04082.18 EDN02479.1 - 6.4e-13 48.3 0.0 1e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FANC_SAP PF18081.1 EDN02479.1 - 0.026 14.7 1.0 0.25 11.5 0.0 2.9 3 0 0 3 3 3 0 Fanconi anemia-associated nuclease SAP domain Exo_endo_phos PF03372.23 EDN02480.1 - 1.9e-08 34.1 0.0 4.4e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ANAPC4_WD40 PF12894.7 EDN02480.1 - 0.0075 16.5 0.0 0.89 9.9 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EDN02480.1 - 0.38 11.3 6.1 6.1 7.5 0.1 4.5 6 0 0 6 6 6 0 PQQ-like domain WD40 PF00400.32 EDN02480.1 - 1 10.3 6.1 5.8 8.0 0.9 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat Ribosomal_L20 PF00453.18 EDN02481.1 - 0.072 13.2 0.5 0.19 11.8 0.5 1.6 1 1 0 1 1 1 0 Ribosomal protein L20 zf-CHY PF05495.12 EDN02482.1 - 2.5e-12 47.1 18.0 5.6e-12 46.0 18.0 1.5 1 1 0 1 1 1 1 CHY zinc finger RNA_POL_M_15KD PF02150.16 EDN02482.1 - 1.6 8.6 12.1 7.4 6.5 1.4 3.3 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit HypA PF01155.19 EDN02482.1 - 4.9 7.2 12.9 22 5.1 12.9 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Proteasome PF00227.26 EDN02483.1 - 1.7e-55 187.5 0.1 2.3e-55 187.1 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDN02483.1 - 5.9e-13 48.2 0.3 2.1e-12 46.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Terminase_5 PF06056.12 EDN02483.1 - 0.047 13.6 0.1 0.097 12.6 0.1 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) MAT1-1-2 PF17043.5 EDN02483.1 - 0.078 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Mating type protein 1-1-2 of unknown function AMP-binding PF00501.28 EDN02484.1 - 2.5e-33 115.3 0.0 1.5e-30 106.1 0.0 2.1 1 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EDN02484.1 - 1.7e-05 25.7 0.6 3.6e-05 24.6 0.6 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain FAD-oxidase_C PF02913.19 EDN02485.1 - 9.8e-63 212.1 0.0 1.3e-62 211.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDN02485.1 - 1.9e-34 118.4 0.3 3.9e-34 117.4 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain Pkinase PF00069.25 EDN02486.1 - 2.2e-69 233.7 0.0 3.3e-69 233.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02486.1 - 4.3e-47 160.6 0.0 7.3e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN02486.1 - 6.9e-06 25.6 0.0 0.00032 20.1 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDN02486.1 - 8.3e-06 24.8 0.3 3.1e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase ABC1 PF03109.16 EDN02486.1 - 0.088 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC1 family T3SS_basalb_I PF17001.5 EDN02486.1 - 0.098 13.3 1.0 0.94 10.1 0.1 2.5 2 0 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI p450 PF00067.22 EDN02488.1 - 1.4e-60 205.3 0.0 1.8e-60 205.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acetyltransf_10 PF13673.7 EDN02489.1 - 2e-08 34.2 0.0 3.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN02489.1 - 2.2e-05 24.7 0.1 6.3e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EDN02489.1 - 2.6e-05 24.3 0.0 5.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN02489.1 - 0.00013 22.3 0.0 0.00022 21.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN02489.1 - 0.07 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 EDN02489.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF4048 PF13257.6 EDN02491.1 - 9.7e-87 291.0 26.7 9.7e-87 291.0 26.7 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4048) TPD52 PF04201.15 EDN02491.1 - 0.013 15.1 0.5 0.026 14.1 0.5 1.5 1 0 0 1 1 1 0 Tumour protein D52 family Bap31_Bap29_C PF18035.1 EDN02491.1 - 0.045 13.8 3.3 0.11 12.5 3.3 1.7 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain IFP_35_N PF07334.13 EDN02491.1 - 0.057 13.5 0.5 0.057 13.5 0.5 2.6 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Roughex PF06020.11 EDN02491.1 - 0.63 9.1 7.1 1.3 8.1 7.1 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Tim17 PF02466.19 EDN02492.1 - 5.7e-39 132.9 5.9 5.7e-39 132.9 5.9 1.9 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Fer4_13 PF13370.6 EDN02492.1 - 0.12 12.9 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I Oxidored_molyb PF00174.19 EDN02493.1 - 3.8e-60 202.4 0.0 5.4e-60 201.9 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Tim17 PF02466.19 EDN02493.1 - 5.7e-38 129.7 5.9 5.7e-38 129.7 5.9 2.6 3 0 0 3 3 3 1 Tim17/Tim22/Tim23/Pmp24 family NAD_binding_10 PF13460.6 EDN02494.1 - 7.5e-07 29.2 0.0 9.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDN02494.1 - 0.019 14.4 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EDN02494.1 - 0.061 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF3435 PF11917.8 EDN02495.1 - 7.9e-168 558.7 0.5 1.1e-167 558.3 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN02495.1 - 2.2e-05 24.3 0.1 0.0032 17.3 0.0 2.5 2 0 0 2 2 2 2 Phage integrase family Acyl_transf_3 PF01757.22 EDN02496.1 - 1.2e-09 37.7 1.3 1.4e-09 37.5 1.3 1.0 1 0 0 1 1 1 1 Acyltransferase family DUF1624 PF07786.12 EDN02496.1 - 0.0067 16.0 0.5 0.013 15.0 0.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1624) F-box-like PF12937.7 EDN02498.1 - 6.1e-06 26.0 0.2 1.3e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 F-box-like APH PF01636.23 EDN02500.1 - 4.6e-12 46.4 0.0 2e-11 44.3 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN02500.1 - 0.0013 18.2 0.0 0.061 12.6 0.0 2.2 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 EDN02500.1 - 0.0035 16.9 0.2 0.0056 16.3 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EDN02500.1 - 0.028 13.3 0.0 0.3 9.9 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1679) Pkinase_fungal PF17667.1 EDN02501.1 - 2.6e-26 92.4 0.2 3.4e-26 92.0 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN02501.1 - 0.0009 18.7 0.1 0.027 13.8 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 EDN02504.1 - 7.5e-128 426.8 0.0 9.2e-128 426.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase SurA_N_3 PF13624.6 EDN02504.1 - 0.018 14.8 0.1 0.032 14.0 0.1 1.3 1 0 0 1 1 1 0 SurA N-terminal domain BCS1_N PF08740.11 EDN02507.1 - 1.1e-35 123.3 0.1 1.8e-35 122.6 0.1 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN02507.1 - 1.3e-19 70.9 0.0 5.6e-19 68.9 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN02507.1 - 1.1e-05 25.8 0.1 2.9e-05 24.5 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN02507.1 - 0.042 12.7 0.0 0.078 11.8 0.0 1.4 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EDN02507.1 - 0.056 13.4 0.0 0.17 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDN02507.1 - 0.056 13.0 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN02507.1 - 0.06 13.1 0.0 0.22 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EDN02507.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EDN02507.1 - 0.078 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 EDN02507.1 - 0.12 12.6 0.0 2.4 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDN02507.1 - 0.12 12.9 0.1 2.1 8.9 0.0 2.6 2 1 0 2 2 2 0 AAA domain Myb_DNA-binding PF00249.31 EDN02508.1 - 7.2e-12 45.3 0.0 1.4e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN02508.1 - 2.2e-05 24.6 0.1 4.8e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA_assoc PF14363.6 EDN02509.1 - 0.017 15.4 0.1 0.033 14.5 0.1 1.5 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA DUF5558 PF17713.1 EDN02510.1 - 0.11 12.8 0.4 0.29 11.5 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5558) zf-C3HC4_3 PF13920.6 EDN02511.1 - 2.6e-05 24.0 10.2 3.9e-05 23.4 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN02511.1 - 0.0008 19.2 3.6 0.0018 18.1 3.6 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN02511.1 - 0.0097 15.7 7.3 0.024 14.5 7.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DegS PF05384.11 EDN02511.1 - 0.013 14.9 0.9 0.019 14.4 0.9 1.2 1 0 0 1 1 1 0 Sensor protein DegS HAUS-augmin3 PF14932.6 EDN02511.1 - 0.014 14.9 0.3 0.02 14.5 0.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.8 EDN02511.1 - 0.02 15.0 0.9 0.029 14.5 0.9 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Sec2p PF06428.11 EDN02511.1 - 0.025 14.6 0.8 0.038 14.0 0.8 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF2570 PF10828.8 EDN02511.1 - 0.034 14.0 0.2 0.05 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) GAS PF13851.6 EDN02511.1 - 0.048 13.0 0.2 0.073 12.4 0.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 EDN02511.1 - 0.074 13.5 1.3 0.13 12.7 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) BRE1 PF08647.11 EDN02511.1 - 0.094 12.8 0.4 0.14 12.2 0.4 1.2 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase APC_N_CC PF16689.5 EDN02511.1 - 0.1 12.6 0.4 0.19 11.8 0.4 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain CCDC158 PF15921.5 EDN02511.1 - 0.13 10.0 0.2 0.17 9.7 0.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Trimer_CC PF08954.11 EDN02511.1 - 0.19 11.3 5.4 0.53 9.9 3.8 2.4 2 1 0 2 2 2 0 Trimerisation motif zf-RING_5 PF14634.6 EDN02511.1 - 0.31 11.0 11.9 0.56 10.2 11.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EDN02511.1 - 0.56 10.6 11.5 1 9.8 11.5 1.4 1 0 0 1 1 1 0 Ring finger domain Myb_DNA-binding PF00249.31 EDN02512.1 - 0.002 18.3 0.2 0.0042 17.2 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4244 PF14029.6 EDN02512.1 - 0.18 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Myb_DNA-binding PF00249.31 EDN02513.1 - 0.0019 18.4 0.2 0.0041 17.3 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4244 PF14029.6 EDN02513.1 - 0.18 11.3 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) PRIMA1 PF16101.5 EDN02514.1 - 0.19 11.8 1.5 0.23 11.5 0.7 1.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF3435 PF11917.8 EDN02515.1 - 1.9e-160 534.4 0.0 2.7e-160 533.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) TPR_12 PF13424.6 EDN02515.1 - 1.4e-143 467.4 42.4 1.4e-20 73.3 0.6 9.5 1 1 9 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 EDN02515.1 - 2e-125 405.8 11.1 7e-12 44.8 0.1 11.9 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_7 PF13176.6 EDN02515.1 - 2.9e-49 161.5 8.1 0.0014 18.5 0.0 12.3 12 0 0 12 12 11 10 Tetratricopeptide repeat TPR_1 PF00515.28 EDN02515.1 - 3.2e-37 124.8 17.6 0.0059 16.4 0.1 11.5 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 EDN02515.1 - 6.8e-25 85.1 16.5 0.16 12.2 0.0 12.4 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_8 PF13181.6 EDN02515.1 - 1.5e-24 84.1 17.9 0.9 9.9 0.0 12.8 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_4 PF07721.14 EDN02515.1 - 3.1e-21 73.7 1.9 1.6 9.6 0.0 10.9 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDN02515.1 - 1.9e-20 71.8 12.4 0.53 11.3 0.2 12.1 10 2 2 12 12 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDN02515.1 - 1.7e-17 63.7 14.7 0.014 16.1 0.4 9.2 6 3 3 9 9 8 6 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN02515.1 - 2.5e-16 60.0 3.2 2.8e-07 30.3 0.1 3.3 2 1 1 3 3 3 3 MalT-like TPR region PNP_UDP_1 PF01048.20 EDN02515.1 - 4.6e-14 52.2 0.1 1.3e-13 50.8 0.1 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily TPR_17 PF13431.6 EDN02515.1 - 4.2e-10 39.3 2.7 65 4.2 0.0 10.1 10 0 0 10 10 10 0 Tetratricopeptide repeat DUF1925 PF09094.11 EDN02515.1 - 1.8e-09 37.8 0.1 1.1e+02 3.3 0.0 9.4 10 0 0 10 10 9 0 Domain of unknown function (DUF1925) TPR_19 PF14559.6 EDN02515.1 - 2.6e-09 37.5 14.9 0.18 12.3 0.3 7.4 4 1 5 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN02515.1 - 2.2e-08 34.2 0.6 3.2 8.0 0.0 7.5 2 1 7 9 9 8 1 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EDN02515.1 - 2.6e-07 30.4 9.2 33 5.0 0.0 9.5 12 0 0 12 12 10 0 PPR repeat Atu4866 PF11512.8 EDN02515.1 - 4.9e-07 30.0 0.7 48 4.4 0.0 7.3 7 0 0 7 7 7 0 Agrobacterium tumefaciens protein Atu4866 NRBF2_MIT PF17169.4 EDN02515.1 - 6.2e-07 29.6 2.9 1.5e+02 2.7 0.0 9.1 10 0 0 10 10 9 0 MIT domain of nuclear receptor-binding factor 2 TPR_3 PF07720.12 EDN02515.1 - 2.3e-06 27.5 0.2 1.4e+02 2.6 0.0 8.3 10 0 0 10 10 8 0 Tetratricopeptide repeat AAA_16 PF13191.6 EDN02515.1 - 2.2e-05 24.9 0.3 0.00029 21.3 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain MIT PF04212.18 EDN02515.1 - 4.2e-05 23.5 0.0 64 3.7 0.0 6.2 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain NB-ARC PF00931.22 EDN02515.1 - 4.5e-05 22.8 0.1 0.00012 21.4 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain NACHT PF05729.12 EDN02515.1 - 7.5e-05 22.7 0.0 0.00018 21.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain nec1 PF10379.9 EDN02515.1 - 0.00012 21.6 0.1 42 3.6 0.0 6.4 1 1 5 7 7 7 0 Virulence protein nec1 DUF1449 PF07290.11 EDN02515.1 - 0.0017 18.0 0.0 1.4e+02 2.0 0.0 5.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1449) zf-C2H2_3rep PF18868.1 EDN02515.1 - 0.24 12.1 2.1 0.85 10.3 2.1 2.0 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EDN02515.1 - 2.8 9.0 6.0 24 6.1 0.3 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger TPR_11 PF13414.6 EDN02515.1 - 5.1 6.9 27.6 74 3.1 0.1 9.5 10 0 0 10 10 10 0 TPR repeat TPR_21 PF09976.9 EDN02515.1 - 8 6.1 18.3 37 3.9 0.1 6.4 2 2 4 7 7 7 0 Tetratricopeptide repeat-like domain Pkinase PF00069.25 EDN02516.1 - 4.7e-05 22.9 1.2 6.2e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 EDN02516.1 - 0.095 12.6 0.1 0.095 12.6 0.1 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family Spore_coat_CotO PF14153.6 EDN02516.1 - 0.25 11.3 6.7 0.43 10.5 6.7 1.3 1 0 0 1 1 1 0 Spore coat protein CotO RR_TM4-6 PF06459.12 EDN02516.1 - 0.29 10.9 5.2 0.43 10.4 5.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 EDN02516.1 - 2 8.4 9.8 22 5.1 0.0 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4472 PF14739.6 EDN02516.1 - 9.4 7.0 18.3 1.7 9.4 0.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Myb_DNA-binding PF00249.31 EDN02517.1 - 1e-13 51.2 0.8 6.2e-12 45.5 0.0 2.6 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN02517.1 - 1.1e-06 28.8 0.4 7.1e-06 26.2 0.1 2.2 1 1 1 2 2 2 1 Myb-like DNA-binding domain AGOG PF09171.10 EDN02517.1 - 0.022 14.1 0.1 0.03 13.7 0.1 1.2 1 0 0 1 1 1 0 N-glycosylase/DNA lyase TIR PF01582.20 EDN02517.1 - 0.054 13.3 0.2 0.066 13.0 0.2 1.2 1 0 0 1 1 1 0 TIR domain BCS1_N PF08740.11 EDN02518.1 - 1.7e-34 119.5 0.0 2.8e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN02518.1 - 1.4e-19 70.8 0.0 5.6e-19 68.9 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN02518.1 - 1.4e-05 25.5 0.1 3.4e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN02518.1 - 0.044 12.6 0.0 0.092 11.6 0.0 1.5 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EDN02518.1 - 0.069 13.2 0.0 0.21 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDN02518.1 - 0.073 12.6 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EDN02518.1 - 0.089 12.5 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EDN02518.1 - 0.09 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.6 EDN02518.1 - 0.097 12.4 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain FKBP_C PF00254.28 EDN02519.1 - 4.8e-20 71.7 0.0 1.1e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RMI1_N PF08585.12 EDN02520.1 - 0.088 12.6 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 RecQ mediated genome instability protein DDE_1 PF03184.19 EDN02521.1 - 6.6e-22 78.0 0.0 1.1e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN02521.1 - 0.00014 21.7 0.0 0.00039 20.2 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease Macoilin PF09726.9 EDN02521.1 - 5.3 5.5 15.1 7.2 5.0 15.1 1.1 1 0 0 1 1 1 0 Macoilin family PALP PF00291.25 EDN02522.1 - 1.3e-68 231.6 0.3 1.6e-68 231.3 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cnd3 PF12719.7 EDN02523.1 - 4e-89 298.7 2.0 2.6e-88 296.1 0.2 2.7 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EDN02523.1 - 7.2e-07 29.5 9.3 0.00063 20.1 0.3 5.0 3 2 2 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 EDN02523.1 - 6.3e-05 23.4 2.1 0.092 13.3 0.3 4.4 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 EDN02523.1 - 7.5e-05 22.7 7.5 0.14 12.5 0.0 5.9 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EDN02523.1 - 0.009 16.1 3.1 0.039 14.0 0.1 3.1 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RICTOR_N PF14664.6 EDN02523.1 - 0.022 13.7 2.7 0.04 12.9 0.0 2.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term DUF629 PF04780.12 EDN02523.1 - 0.054 12.0 0.3 0.11 11.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF629) MMS19_N PF14500.6 EDN02523.1 - 0.1 12.2 0.6 2.4 7.7 0.0 3.1 2 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Eapp_C PF10238.9 EDN02523.1 - 1.6 8.8 6.0 4.2 7.4 0.2 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein zf-RanBP PF00641.18 EDN02524.1 - 1.8e-20 71.9 8.3 6.8e-11 41.3 1.6 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RNase_T PF00929.24 EDN02524.1 - 6.6e-06 26.8 0.0 1e-05 26.2 0.0 1.2 1 0 0 1 1 1 1 Exonuclease F-box-like PF12937.7 EDN02525.1 - 3.1e-10 39.8 2.2 8.8e-10 38.3 2.2 1.8 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EDN02525.1 - 0.0009 19.1 2.4 0.48 10.4 0.6 2.8 2 0 0 2 2 2 2 F-box domain LRR_4 PF12799.7 EDN02525.1 - 0.06 13.8 8.5 1.5 9.4 0.7 4.1 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) SKG6 PF08693.10 EDN02526.1 - 0.00025 20.4 0.3 0.0007 19.0 0.3 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain HTH_Tnp_Tc5 PF03221.16 EDN02527.1 - 2.4e-09 37.1 0.1 4.3e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN02527.1 - 8.7e-05 22.2 0.1 0.00019 21.1 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Chol_subst-bind PF09129.11 EDN02527.1 - 0.04 12.9 0.7 0.083 11.8 0.2 1.8 2 0 0 2 2 2 0 Cholesterol oxidase, substrate-binding CDC45 PF02724.14 EDN02528.1 - 0.82 7.9 6.7 1.1 7.5 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EDN02528.1 - 1.4 7.0 5.8 1.7 6.6 5.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Adeno_terminal PF02459.15 EDN02528.1 - 2.3 6.5 5.0 2.8 6.2 5.0 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein FAM176 PF14851.6 EDN02528.1 - 2.9 7.5 6.4 0.34 10.6 1.5 1.8 2 0 0 2 2 2 0 FAM176 family DUF3431 PF11913.8 EDN02531.1 - 7.5e-85 284.1 0.0 9.9e-85 283.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DMPK_coil PF08826.10 EDN02531.1 - 0.74 10.0 4.4 12 6.1 0.4 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like PH PF00169.29 EDN02532.1 - 7.2e-05 23.2 0.3 0.00019 21.9 0.3 1.7 1 0 0 1 1 1 1 PH domain BCL_N PF04714.13 EDN02532.1 - 0.027 14.5 0.1 0.077 13.1 0.1 1.8 1 0 0 1 1 1 0 BCL7, N-terminal conserver region PH_11 PF15413.6 EDN02532.1 - 0.23 11.9 1.4 0.8 10.2 1.4 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain RmlD_sub_bind PF04321.17 EDN02533.1 - 9.2e-48 162.8 0.0 3.1e-47 161.1 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EDN02533.1 - 3.1e-22 79.2 0.0 3.9e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDN02533.1 - 3.9e-12 46.2 0.0 5.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDN02533.1 - 1.2e-10 41.0 0.0 5e-08 32.4 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EDN02533.1 - 1.1e-08 34.5 0.0 1.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EDN02533.1 - 1.2e-08 34.4 0.2 1.5e-07 30.9 0.2 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EDN02533.1 - 0.056 13.3 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 EDN02534.1 - 3.7e-25 88.5 0.1 5.9e-18 65.0 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN02534.1 - 3e-17 63.0 0.0 5.2e-10 39.3 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN02534.1 - 1.2e-05 25.3 0.1 2.3e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EDN02534.1 - 0.012 15.8 0.1 0.028 14.7 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EDN02534.1 - 0.02 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EDN02534.1 - 0.1 12.7 0.2 0.29 11.2 0.1 1.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkH PF02386.16 EDN02536.1 - 5.6e-141 470.4 4.1 5.6e-141 470.4 4.1 1.4 2 0 0 2 2 2 1 Cation transport protein Toxin_12 PF07740.12 EDN02537.1 - 0.046 14.4 2.6 0.046 14.4 2.6 2.1 2 0 0 2 2 2 0 Ion channel inhibitory toxin Tachystatin_A PF11406.8 EDN02537.1 - 0.077 13.1 5.0 0.14 12.3 5.0 1.5 1 1 0 1 1 1 0 Antimicrobial peptide tachystatin A Conotoxin_I2 PF17557.2 EDN02537.1 - 0.1 12.7 4.5 0.1 12.7 4.5 1.6 2 0 0 2 2 2 0 I2-superfamily conotoxins Toxin_19 PF08088.12 EDN02537.1 - 0.43 10.7 8.2 1.2 9.4 8.2 1.7 1 1 0 1 1 1 0 Conotoxin I-superfamily Pkinase PF00069.25 EDN02538.1 - 1.3e-14 54.2 0.0 3e-14 53.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02538.1 - 0.00024 20.5 0.0 0.00044 19.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Dynamin_M PF01031.20 EDN02539.1 - 1.1e-100 336.6 0.0 1.9e-100 335.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EDN02539.1 - 6.9e-48 162.9 0.3 1.2e-47 162.0 0.3 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EDN02539.1 - 6e-29 100.0 5.4 6e-29 100.0 5.4 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDN02539.1 - 3.5e-05 23.9 1.1 0.00013 22.0 1.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDN02539.1 - 0.0093 15.3 0.1 0.45 9.8 0.0 2.4 2 0 0 2 2 2 1 AIG1 family FeoB_N PF02421.18 EDN02539.1 - 0.13 11.7 0.5 15 5.1 0.0 2.5 1 1 1 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 EDN02539.1 - 0.17 12.1 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 EDN02540.1 - 8.9e-104 345.8 0.0 1.3e-103 345.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EDN02540.1 - 1.4e-34 118.6 0.0 2.7e-34 117.6 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EDN02540.1 - 1.4e-05 25.5 0.5 3.1e-05 24.4 0.5 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain YccJ PF13993.6 EDN02540.1 - 0.051 13.9 0.2 0.2 12.0 0.1 2.0 2 0 0 2 2 2 0 YccJ-like protein NB-ARC PF00931.22 EDN02540.1 - 0.2 10.8 0.0 1.4 8.1 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain WD40 PF00400.32 EDN02541.1 - 1.5e-19 69.9 12.1 4.7e-05 24.1 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN02541.1 - 1.9e-11 44.1 0.6 0.0097 16.2 0.0 5.6 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN02541.1 - 0.00071 19.5 0.1 0.0058 16.5 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EDN02541.1 - 0.001 18.9 0.2 7.4 6.6 0.0 4.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat CLTH PF10607.9 EDN02541.1 - 0.0019 18.1 0.1 0.0033 17.3 0.1 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Nup160 PF11715.8 EDN02541.1 - 0.0071 15.0 0.1 0.011 14.4 0.1 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDN02541.1 - 0.01 14.8 0.1 0.2 10.6 0.0 2.6 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DEAD PF00270.29 EDN02542.1 - 7.4e-42 143.1 0.2 1.3e-41 142.3 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN02542.1 - 2.4e-33 114.8 0.1 8.1e-33 113.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EDN02542.1 - 0.0012 18.6 0.1 0.0018 18.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDN02542.1 - 0.0015 18.6 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDN02542.1 - 0.0043 17.4 0.1 0.037 14.4 0.1 2.1 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 EDN02542.1 - 0.057 13.4 0.1 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 EDN02542.1 - 0.08 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 EDN02542.1 - 0.093 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 EDN02542.1 - 0.33 11.2 1.4 1.8 8.8 1.4 2.1 1 1 0 1 1 1 0 AAA domain DUF3449 PF11931.8 EDN02543.1 - 1.1e-75 253.5 1.5 1.1e-75 253.5 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EDN02543.1 - 6.8e-25 87.4 1.4 6.8e-25 87.4 1.4 2.1 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EDN02543.1 - 1.9e-15 56.4 1.4 4.7e-15 55.2 1.4 1.7 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_jaz PF12171.8 EDN02543.1 - 2.9e-09 37.0 1.1 2.4e-08 34.1 0.6 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDN02543.1 - 4.2e-08 33.3 1.5 1.3e-06 28.5 0.7 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDN02543.1 - 0.00078 19.7 0.0 0.015 15.6 0.0 2.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EDN02543.1 - 0.056 14.3 0.8 2.7 9.1 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-LYAR PF08790.11 EDN02543.1 - 0.16 11.9 0.2 0.42 10.6 0.2 1.7 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger PRP9_N PF16958.5 EDN02543.1 - 0.16 12.0 14.4 0.32 11.0 0.6 3.3 3 1 1 4 4 4 0 Pre-mRNA-splicing factor PRP9 N-terminus DNA_ligase_A_M PF01068.21 EDN02544.1 - 4e-18 65.8 0.0 5.6e-11 42.5 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDN02544.1 - 7.5e-07 29.6 0.0 1.4e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus TPR_8 PF13181.6 EDN02545.1 - 7.1e-15 53.9 9.0 0.00063 19.8 0.0 5.1 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDN02545.1 - 4.1e-13 48.5 9.0 0.0034 17.1 0.0 5.2 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDN02545.1 - 3e-12 45.6 15.3 0.026 14.6 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN02545.1 - 1.8e-10 40.3 2.6 3e-07 30.0 0.2 3.5 4 0 0 4 4 4 2 TPR repeat TPR_16 PF13432.6 EDN02545.1 - 1.4e-09 38.4 12.0 8.3e-06 26.4 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDN02545.1 - 1.5e-07 31.7 17.3 0.032 15.1 0.0 5.8 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDN02545.1 - 5.7e-07 29.5 1.2 2.2 8.8 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDN02545.1 - 2.5e-06 27.9 11.8 0.04 14.4 0.0 4.9 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN02545.1 - 1.8e-05 24.9 10.4 0.12 12.7 0.0 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDN02545.1 - 4.5e-05 23.2 8.8 0.055 13.5 0.1 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDN02545.1 - 8.4e-05 22.6 11.7 0.00067 19.8 0.8 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDN02545.1 - 0.00018 21.9 18.9 0.53 11.0 0.3 6.3 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDN02545.1 - 0.01 15.1 3.6 0.13 11.5 0.7 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN02545.1 - 0.037 14.2 3.0 3.9 7.8 0.1 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2457 PF10446.9 EDN02545.1 - 0.041 13.0 4.0 0.052 12.7 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TPR_10 PF13374.6 EDN02545.1 - 0.061 13.2 9.0 0.84 9.6 0.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 EDN02545.1 - 0.14 12.2 1.2 0.64 10.1 0.1 2.4 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) CDC45 PF02724.14 EDN02545.1 - 0.37 9.0 1.6 0.43 8.8 1.6 1.1 1 0 0 1 1 1 0 CDC45-like protein ANAPC8 PF04049.13 EDN02546.1 - 5.7e-53 178.7 0.0 5.7e-53 178.7 0.0 1.8 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 DDE_Tnp_1_7 PF13843.6 EDN02546.1 - 4.5e-22 78.8 2.2 6.3e-07 29.0 0.4 4.3 2 2 2 4 4 4 4 Transposase IS4 Neisseria_TspB PF05616.13 EDN02546.1 - 2.5 6.5 7.3 3.7 5.9 7.3 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PNP_UDP_1 PF01048.20 EDN02548.1 - 6.3e-08 32.2 0.1 0.0008 18.7 0.0 2.3 2 1 0 2 2 2 2 Phosphorylase superfamily DUF4756 PF15948.5 EDN02548.1 - 0.097 12.5 0.3 0.17 11.7 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4756) HHH_8 PF14716.6 EDN02548.1 - 0.17 12.2 0.1 0.76 10.2 0.0 2.1 1 1 1 2 2 2 0 Helix-hairpin-helix domain polyprenyl_synt PF00348.17 EDN02549.1 - 1.1e-89 299.9 0.0 1.5e-89 299.5 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Phospholip_A2_3 PF09056.11 EDN02550.1 - 1.5e-32 112.5 0.6 1.8e-32 112.3 0.6 1.1 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 Glycogen_syn PF05693.13 EDN02551.1 - 0 1146.9 0.0 0 1146.7 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EDN02551.1 - 2.3e-05 24.0 0.0 0.0044 16.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDN02551.1 - 2.8e-05 24.6 0.0 0.035 14.5 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDN02551.1 - 3.8e-05 23.7 0.3 8.4e-05 22.6 0.3 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EDN02551.1 - 7.9e-05 23.2 0.1 0.00017 22.0 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Vps54 PF07928.12 EDN02552.1 - 1.8e-52 177.4 1.9 5.8e-52 175.7 0.8 2.6 3 0 0 3 3 3 1 Vps54-like protein Vps54_N PF10475.9 EDN02552.1 - 4.5e-08 32.7 1.1 1.2e-07 31.3 1.1 1.7 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EDN02552.1 - 3.6e-07 30.2 1.1 2.9e-06 27.3 0.4 2.3 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) DUF4363 PF14276.6 EDN02552.1 - 7.7 6.7 5.8 2.5 8.2 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) MCM PF00493.23 EDN02553.1 - 3.3e-104 346.9 0.1 1.3e-103 345.0 0.0 1.8 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EDN02553.1 - 2.8e-37 127.4 0.3 5.3e-37 126.5 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDN02553.1 - 1.5e-29 102.3 2.4 2.6e-29 101.5 1.4 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EDN02553.1 - 3e-15 56.7 0.7 6.5e-15 55.6 0.7 1.5 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDN02553.1 - 4.2e-06 26.3 0.0 0.0007 19.0 0.0 2.4 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDN02553.1 - 5.3e-05 23.2 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDN02553.1 - 0.00052 19.9 0.0 0.0018 18.1 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDN02553.1 - 0.04 13.6 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 EDN02553.1 - 0.096 13.1 0.1 0.58 10.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MFS_1 PF07690.16 EDN02554.1 - 1.3e-25 90.1 23.2 1.9e-25 89.6 23.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN02554.1 - 1.6e-08 33.5 10.3 2.2e-08 33.0 10.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDN02554.1 - 2.4e-07 30.0 11.0 2.4e-07 30.0 11.0 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter Spore_III_AF PF09581.10 EDN02554.1 - 0.035 14.2 0.2 0.066 13.2 0.2 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) MFS_1_like PF12832.7 EDN02554.1 - 0.13 11.1 11.1 0.041 12.7 7.8 1.7 2 0 0 2 2 2 0 MFS_1 like family Peptidase_U4 PF03419.13 EDN02554.1 - 2 7.7 14.2 0.42 9.9 0.2 2.4 2 1 0 2 2 2 0 Sporulation factor SpoIIGA ECH_1 PF00378.20 EDN02555.1 - 7.4e-12 45.1 0.0 8.6e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN02555.1 - 1.5e-08 34.5 0.0 1.8e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF1464 PF07318.12 EDN02555.1 - 0.082 12.0 0.1 0.18 10.9 0.1 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1464) PfkB PF00294.24 EDN02556.1 - 2.4e-28 99.3 0.8 3.6e-14 52.8 0.2 3.9 2 2 0 2 2 2 2 pfkB family carbohydrate kinase Tau95 PF09734.9 EDN02558.1 - 4.5e-39 134.4 0.4 7.3e-39 133.8 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EDN02558.1 - 1.3e-31 109.4 0.0 2.6e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 Tau95 Triple barrel domain DUF4568 PF15132.6 EDN02558.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) SOCS PF12610.8 EDN02558.1 - 0.1 13.0 0.3 0.36 11.2 0.3 1.9 1 0 0 1 1 1 0 Suppressor of cytokine signalling Mucin PF01456.17 EDN02558.1 - 3 7.8 9.6 0.085 12.8 3.0 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein B56 PF01603.20 EDN02560.1 - 1.1e-186 620.8 4.1 1.3e-186 620.6 4.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EDN02560.1 - 0.0056 16.6 2.1 2.8 7.8 0.0 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3417 PF11897.8 EDN02560.1 - 0.14 12.6 2.0 0.45 11.0 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3417) FAT PF02259.23 EDN02561.1 - 6.5e-73 245.9 11.2 1.4e-72 244.9 11.2 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EDN02561.1 - 5.6e-32 111.5 1.1 1.5e-31 110.1 0.1 2.1 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EDN02561.1 - 9.5e-08 31.7 0.1 2.9e-07 30.2 0.1 2.0 1 0 0 1 1 1 1 FATC domain DUF572 PF04502.13 EDN02562.1 - 5.4e-71 239.9 16.4 6.3e-71 239.7 16.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF951 PF06107.11 EDN02562.1 - 0.074 13.0 0.2 5 7.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) DNA_RNApol_7kD PF03604.13 EDN02562.1 - 0.11 12.1 2.4 8 6.2 0.4 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-FCS PF06467.14 EDN02562.1 - 0.18 11.8 3.8 0.85 9.6 0.1 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif YjbH PF06082.11 EDN02562.1 - 0.5 9.1 2.8 0.63 8.8 2.8 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH zinc_ribbon_2 PF13240.6 EDN02562.1 - 0.86 9.4 3.6 1.2 9.0 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-ACC PF17848.1 EDN02562.1 - 0.92 9.6 3.6 3.5 7.8 0.8 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain TF_Zn_Ribbon PF08271.12 EDN02562.1 - 2 8.0 6.3 3.2 7.4 1.6 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EDN02562.1 - 4 7.6 8.0 23 5.2 0.1 3.4 2 1 0 2 2 2 0 Zinc ribbon domain D5_N PF08706.11 EDN02562.1 - 8.8 6.6 11.4 4.4 7.6 8.5 2.0 2 1 0 2 2 2 0 D5 N terminal like TPR_2 PF07719.17 EDN02563.1 - 1.1e-29 100.1 11.1 0.00019 21.3 0.0 10.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDN02563.1 - 4.4e-27 92.7 7.3 0.0018 18.0 0.2 10.0 11 0 0 11 11 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN02563.1 - 5.4e-23 81.0 19.5 2.1e-22 79.1 1.4 5.8 6 1 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EDN02563.1 - 1.9e-18 66.7 11.2 0.0017 18.9 0.0 6.9 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDN02563.1 - 1.3e-15 57.4 29.4 1.1e-09 38.5 0.6 9.6 7 3 2 9 9 9 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDN02563.1 - 4e-14 51.6 8.8 0.19 12.0 0.0 9.0 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDN02563.1 - 6.9e-14 52.2 22.0 0.029 15.0 0.0 8.5 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDN02563.1 - 3.4e-13 49.2 16.6 0.69 10.9 0.3 9.4 7 3 3 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN02563.1 - 5e-12 45.3 0.9 0.39 10.4 0.1 8.0 8 1 0 8 8 8 3 TPR repeat TPR_7 PF13176.6 EDN02563.1 - 1.2e-09 37.5 17.5 0.035 14.1 0.1 8.8 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDN02563.1 - 8.2e-09 35.1 15.8 0.00026 20.8 0.1 6.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDN02563.1 - 4e-08 33.4 11.2 1.9 9.3 0.0 8.0 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 EDN02563.1 - 7.3e-08 32.3 11.7 0.043 14.4 2.0 7.8 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDN02563.1 - 8e-06 25.9 2.7 5.2 7.7 0.0 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN02563.1 - 0.00041 19.8 5.8 0.0033 16.8 0.2 3.4 3 1 0 3 3 3 1 MalT-like TPR region TPR_21 PF09976.9 EDN02563.1 - 0.0012 18.6 3.2 6.7 6.4 0.0 4.9 5 1 0 5 5 5 1 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 EDN02563.1 - 0.004 17.2 0.1 0.036 14.1 0.0 2.5 2 0 0 2 2 2 1 Putative TPR-like repeat TPR_9 PF13371.6 EDN02563.1 - 0.59 10.3 15.8 3.8 7.7 0.1 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat SNAP PF14938.6 EDN02563.1 - 4.8 6.5 7.6 13 5.1 0.1 3.5 5 0 0 5 5 5 0 Soluble NSF attachment protein, SNAP p450 PF00067.22 EDN02564.1 - 2.9e-71 240.6 0.0 3.5e-71 240.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 EDN02565.1 - 3.2e-65 220.0 0.0 4.1e-65 219.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN02565.1 - 7e-55 185.5 0.6 8.5e-55 185.2 0.6 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN02565.1 - 6.2e-09 36.0 0.5 1.7e-08 34.6 0.5 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EDN02565.1 - 0.002 17.6 0.0 0.0036 16.8 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Enoyl_reductase PF12241.8 EDN02565.1 - 0.079 12.3 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region DFP PF04127.15 EDN02565.1 - 0.085 12.7 0.3 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DUF1996 PF09362.10 EDN02566.1 - 6.2e-84 281.6 0.1 8.2e-84 281.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Cyclase PF04199.13 EDN02569.1 - 5.1e-06 26.8 0.0 7.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase Sugar_tr PF00083.24 EDN02570.1 - 3.6e-75 253.6 23.2 4.2e-75 253.3 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN02570.1 - 8.3e-16 57.8 39.5 4.4e-12 45.6 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 EDN02570.1 - 2.4 6.3 10.3 0.27 9.5 4.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Pyr_redox_2 PF07992.14 EDN02571.1 - 7.6e-34 117.3 1.0 9.9e-34 116.9 1.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN02571.1 - 4.6e-11 43.1 0.1 7.4e-09 36.1 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PGK PF00162.19 EDN02571.1 - 0.007 15.3 0.5 0.052 12.5 0.2 2.1 2 0 0 2 2 2 1 Phosphoglycerate kinase Lycopene_cycl PF05834.12 EDN02571.1 - 0.011 14.8 0.1 2 7.4 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein K_oxygenase PF13434.6 EDN02571.1 - 0.019 14.1 0.2 0.56 9.3 0.2 2.8 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 EDN02571.1 - 0.021 14.1 0.4 0.07 12.4 0.0 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase CoA_binding_2 PF13380.6 EDN02571.1 - 0.041 14.4 0.5 0.17 12.4 0.1 2.1 2 1 0 2 2 2 0 CoA binding domain ELO PF01151.18 EDN02572.1 - 1.2e-25 90.5 8.5 1.4e-25 90.2 8.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family COX5A PF02284.16 EDN02573.1 - 3e-39 133.2 0.6 3.8e-39 132.8 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va SurA_N_3 PF13624.6 EDN02573.1 - 0.0021 17.9 0.1 0.0038 17.0 0.1 1.6 1 1 0 1 1 1 1 SurA N-terminal domain Zn_clus PF00172.18 EDN02574.1 - 2.2e-06 27.7 12.2 4e-06 26.8 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDN02574.1 - 6.7e-05 22.0 0.1 0.00014 21.0 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EDN02575.1 - 4.9e-33 114.5 34.8 4.7e-32 111.3 30.4 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDN02575.1 - 3.8e-08 32.2 4.4 5.9e-08 31.6 4.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) NKAIN PF05640.14 EDN02575.1 - 0.018 14.3 0.0 0.018 14.3 0.0 1.6 2 0 0 2 2 2 0 Na,K-Atpase Interacting protein MFS_Mycoplasma PF07672.13 EDN02575.1 - 0.46 9.7 8.7 0.26 10.5 6.2 1.8 2 0 0 2 2 2 0 Mycoplasma MFS transporter Phage_holin_2_4 PF16082.5 EDN02575.1 - 0.88 9.4 5.0 0.74 9.6 0.1 2.7 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like GATase_5 PF13507.6 EDN02576.1 - 3.2e-100 334.5 0.0 5.2e-100 333.8 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EDN02576.1 - 6.7e-39 133.5 0.4 1e-23 84.2 0.3 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EDN02576.1 - 3.7e-33 113.9 0.0 8.6e-33 112.8 0.0 1.7 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EDN02576.1 - 1.6e-21 76.6 0.0 3.5e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain TruB_C PF09142.11 EDN02576.1 - 0.15 11.9 0.1 0.66 9.8 0.0 2.2 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Ribosomal_L7Ae PF01248.26 EDN02576.1 - 0.17 11.6 0.1 0.44 10.3 0.1 1.7 1 1 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Homez PF11569.8 EDN02576.1 - 0.19 11.2 0.1 0.43 10.1 0.1 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez GCP_N_terminal PF17681.1 EDN02577.1 - 1.8e-33 116.5 0.3 3.3e-33 115.6 0.3 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDN02577.1 - 1.7e-23 83.6 2.3 1.7e-23 83.6 2.3 2.1 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EDN02577.1 - 0.016 13.6 0.8 0.09 11.1 0.2 2.1 2 0 0 2 2 2 0 gamma-Tubulin ring complex non-core subunit mod21 Glyco_transf_15 PF01793.16 EDN02578.1 - 7.2e-112 373.8 12.7 8.9e-112 373.5 12.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Peptidase_S8 PF00082.22 EDN02579.1 - 1.3e-40 139.5 0.1 1.9e-40 139.0 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Methyltransf_32 PF13679.6 EDN02580.1 - 1.7e-18 67.1 0.4 1.1e-17 64.5 0.4 2.0 1 1 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.11 EDN02582.1 - 3.2e-27 95.0 0.6 2.7e-26 92.0 0.0 2.3 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EDN02582.1 - 7.5e-05 22.6 2.7 8.3e-05 22.5 1.2 1.9 2 0 0 2 2 2 1 SNARE domain DUF2072 PF09845.9 EDN02582.1 - 0.025 14.8 0.5 0.075 13.3 0.0 1.9 2 0 0 2 2 2 0 Zn-ribbon containing protein FAM184 PF15665.5 EDN02582.1 - 0.046 13.5 2.1 0.058 13.2 0.7 1.7 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DUF3618 PF12277.8 EDN02582.1 - 0.1 12.9 8.6 0.9 9.8 0.2 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3618) Laminin_II PF06009.12 EDN02582.1 - 0.11 12.6 0.4 3.5 7.6 0.0 2.4 2 1 0 2 2 2 0 Laminin Domain II NPV_P10 PF05531.12 EDN02582.1 - 0.12 12.9 3.6 1.2 9.6 0.2 3.0 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein NAP PF00956.18 EDN02583.1 - 5.4e-11 42.2 5.7 1.3e-08 34.3 5.1 2.8 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) NmrA PF05368.13 EDN02584.1 - 1.2e-65 221.4 0.0 1.7e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Mucin PF01456.17 EDN02584.1 - 0.14 12.1 14.0 0.25 11.3 14.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein ADH_N PF08240.12 EDN02585.1 - 0.0039 17.1 0.0 0.022 14.7 0.0 2.2 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Asparaginase PF00710.20 EDN02586.1 - 1.7e-53 181.0 0.0 5.6e-53 179.3 0.0 1.8 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EDN02586.1 - 6e-28 97.4 0.2 1.6e-27 96.0 0.2 1.7 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain MTTB PF06253.11 EDN02586.1 - 0.11 10.4 0.2 0.17 9.9 0.2 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Fungal_trans_2 PF11951.8 EDN02587.1 - 0.017 13.9 0.1 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain DEC-1_N PF04625.13 EDN02587.1 - 6.8 5.6 7.4 11 4.9 7.4 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region LCCL PF03815.19 EDN02590.1 - 3e-14 52.9 0.0 5.1e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Chromo PF00385.24 EDN02591.1 - 0.0021 17.9 0.1 0.011 15.6 0.1 2.0 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase_fungal PF17667.1 EDN02592.1 - 1.7e-114 382.8 0.0 2.5e-114 382.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase ACT_7 PF13840.6 EDN02593.1 - 8.1e-23 80.0 0.1 2.8e-17 62.3 0.0 3.4 3 0 0 3 3 3 3 ACT domain WD40 PF00400.32 EDN02594.1 - 1.1e-19 70.4 14.6 0.00051 20.8 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN02594.1 - 3.8e-09 36.7 0.3 1.1 9.7 0.0 5.0 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 EDN02594.1 - 0.0076 15.3 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain Nup160 PF11715.8 EDN02594.1 - 0.11 11.1 3.0 2 6.9 0.3 2.7 1 1 2 3 3 3 0 Nucleoporin Nup120/160 UBD PF16455.5 EDN02594.1 - 0.14 12.5 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-binding domain PQQ PF01011.21 EDN02594.1 - 0.33 11.0 3.0 38 4.5 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat Septin PF00735.18 EDN02595.1 - 7.8e-113 376.4 0.2 7.8e-113 376.4 0.2 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDN02595.1 - 1.3e-07 31.7 0.0 2.8e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDN02595.1 - 5e-06 26.5 0.5 5.8e-05 23.1 0.0 2.6 3 0 0 3 3 2 1 RsgA GTPase GTP_EFTU PF00009.27 EDN02595.1 - 1.1e-05 25.1 3.8 0.00011 21.8 0.1 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EDN02595.1 - 0.0022 18.3 0.6 0.0075 16.5 0.0 2.1 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 EDN02595.1 - 0.0028 17.1 0.1 0.0052 16.3 0.1 1.3 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 EDN02595.1 - 0.0035 17.5 0.1 0.0076 16.5 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EDN02595.1 - 0.0055 16.1 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 EDN02595.1 - 0.0071 15.4 0.0 0.014 14.5 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.6 EDN02595.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDN02595.1 - 0.024 15.0 0.7 0.087 13.2 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain FOXP-CC PF16159.5 EDN02595.1 - 0.027 15.1 2.0 0.047 14.3 0.8 2.0 1 1 1 2 2 1 0 FOXP coiled-coil domain AAA_25 PF13481.6 EDN02595.1 - 0.03 13.9 0.4 0.37 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ras PF00071.22 EDN02595.1 - 0.031 13.9 0.5 0.086 12.4 0.3 1.9 2 1 0 2 2 2 0 Ras family KAP_NTPase PF07693.14 EDN02595.1 - 0.036 13.3 0.0 0.047 12.9 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain Casc1_N PF15927.5 EDN02595.1 - 0.037 13.7 10.4 0.089 12.5 10.4 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus T2SSE PF00437.20 EDN02595.1 - 0.043 12.9 0.0 0.12 11.4 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 EDN02595.1 - 0.047 14.2 0.1 0.28 11.7 0.0 2.2 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 EDN02595.1 - 0.053 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 EDN02595.1 - 0.087 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EDN02595.1 - 0.15 11.8 0.3 5.3 6.8 0.3 2.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EDN02595.1 - 0.18 12.2 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP_bind_1 PF03029.17 EDN02595.1 - 0.25 11.1 0.7 13 5.5 0.1 2.6 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Exonuc_VII_L PF02601.15 EDN02595.1 - 0.26 10.8 3.7 0.41 10.2 3.7 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Dynamin_N PF00350.23 EDN02595.1 - 0.35 10.9 5.5 4.6 7.3 0.0 3.1 2 1 1 3 3 3 0 Dynamin family DegS PF05384.11 EDN02595.1 - 3.7 7.0 12.2 3.1 7.3 8.2 2.5 2 1 1 3 3 3 0 Sensor protein DegS Myc-LZ PF02344.15 EDN02595.1 - 5.7 7.1 11.5 5.1 7.3 5.3 3.1 2 1 0 2 2 2 0 Myc leucine zipper domain WD40 PF00400.32 EDN02596.1 - 1.6e-39 133.2 32.0 5.1e-09 36.6 0.8 11.7 13 0 0 13 13 13 7 WD domain, G-beta repeat Utp12 PF04003.12 EDN02596.1 - 3.5e-25 88.4 0.0 5.8e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EDN02596.1 - 4.2e-21 75.1 0.0 0.014 15.7 0.0 9.7 5 1 4 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN02596.1 - 5.3e-10 38.8 0.1 0.29 10.0 0.0 5.7 5 2 2 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDN02596.1 - 2.5e-08 34.1 1.4 0.018 14.9 0.1 5.9 6 2 1 7 7 7 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDN02596.1 - 0.0026 16.5 1.2 2.7 6.5 0.0 3.9 2 2 1 3 3 3 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EDN02596.1 - 0.0095 16.4 0.3 32 5.2 0.0 4.7 4 0 0 4 4 4 0 PQQ-like domain WD40_like PF17005.5 EDN02596.1 - 0.015 14.6 0.0 0.26 10.6 0.0 2.8 4 0 0 4 4 4 0 WD40-like domain Utp21 PF04192.12 EDN02596.1 - 0.022 14.3 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain COMP PF11598.8 EDN02596.1 - 0.16 12.5 0.0 0.35 11.4 0.0 1.6 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein SKIP_SNW PF02731.15 EDN02597.1 - 1.1e-71 239.7 5.6 1.1e-71 239.7 5.6 2.4 2 0 0 2 2 2 1 SKIP/SNW domain Keratin_2_head PF16208.5 EDN02598.1 - 1.7 8.7 19.3 0.21 11.8 14.4 1.9 2 0 0 2 2 2 0 Keratin type II head DUF3395 PF11875.8 EDN02600.1 - 2.3e-20 73.1 0.5 4.2e-20 72.2 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EDN02600.1 - 1.6e-14 53.8 1.2 3.5e-14 52.7 1.2 1.6 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.18 EDN02601.1 - 2.1e-11 43.4 0.0 3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_L4 PF00573.22 EDN02604.1 - 2.3e-37 128.5 0.1 3.1e-37 128.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EDN02604.1 - 6.5e-29 99.8 0.6 6.5e-29 99.8 0.6 1.9 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain RVT_2 PF07727.14 EDN02605.1 - 1e-43 149.7 0.0 1.5e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN02605.1 - 4.3e-09 36.6 0.0 1.3e-08 35.0 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Glyco_hydro_61 PF03443.14 EDN02607.1 - 0.00016 21.7 0.0 0.00035 20.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 AMP-binding PF00501.28 EDN02608.1 - 6.4e-43 146.9 0.0 9e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EDN02608.1 - 0.00011 22.0 0.6 0.00011 22.0 0.6 2.3 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EDN02608.1 - 0.097 13.7 0.0 0.24 12.4 0.0 1.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain UPF0029 PF01205.19 EDN02609.1 - 1.1e-07 32.2 0.0 1.6e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EDN02609.1 - 1.4e-05 25.4 0.0 2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 RWD domain Aminotran_1_2 PF00155.21 EDN02610.1 - 6.1e-09 35.5 0.0 6.4e-08 32.2 0.0 2.3 2 1 0 2 2 2 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EDN02610.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase RT_RNaseH PF17917.1 EDN02611.1 - 8.1e-35 119.3 0.0 7e-34 116.3 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN02611.1 - 3.3e-33 115.1 0.1 5.4e-33 114.4 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN02611.1 - 1.2e-23 83.0 0.3 1.8e-12 47.1 0.0 3.1 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN02611.1 - 3.2e-19 68.8 0.2 8.1e-19 67.5 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN02611.1 - 2.1e-15 57.0 0.0 7.3e-15 55.2 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN02611.1 - 7.2e-14 51.4 1.5 2.1e-13 50.0 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN02611.1 - 1.7e-05 24.9 0.1 4e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Retrotrans_gag PF03732.17 EDN02611.1 - 0.00063 20.0 2.7 0.00063 20.0 2.7 2.7 2 0 0 2 2 2 1 Retrotransposon gag protein Mtf2_C PF14061.6 EDN02611.1 - 0.036 14.2 1.0 0.37 11.0 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 Retrotran_gag_2 PF14223.6 EDN02611.1 - 0.096 12.4 1.9 0.24 11.1 1.9 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type PSII_Pbs27 PF13326.6 EDN02611.1 - 0.14 12.5 0.0 0.79 10.0 0.0 2.2 2 0 0 2 2 2 0 Photosystem II Pbs27 2-Hacid_dh_C PF02826.19 EDN02612.1 - 0.091 12.1 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain LprI PF07007.12 EDN02612.1 - 0.1 13.3 0.2 0.15 12.7 0.2 1.3 1 0 0 1 1 1 0 Lysozyme inhibitor LprI Chromo PF00385.24 EDN02613.1 - 0.0012 18.7 0.1 0.007 16.2 0.1 2.1 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Helo_like_N PF17111.5 EDN02614.1 - 2.6e-48 164.2 0.1 3.1e-48 163.9 0.1 1.0 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins DUF1732 PF08340.11 EDN02614.1 - 0.017 15.1 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1732) SesA PF17107.5 EDN02614.1 - 0.11 12.6 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Pkinase_fungal PF17667.1 EDN02615.1 - 2.7e-143 477.7 0.0 3.3e-143 477.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN02615.1 - 3.1e-07 30.0 0.0 5.3e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02615.1 - 0.012 14.9 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase HSDR_N_2 PF13588.6 EDN02616.1 - 0.011 15.7 0.0 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) ORC_WH_C PF18137.1 EDN02616.1 - 0.23 11.5 6.8 0.62 10.1 6.8 1.6 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal AAA PF00004.29 EDN02618.1 - 0.031 14.7 0.0 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) POX PF07526.11 EDN02618.1 - 0.1 13.2 1.6 0.36 11.4 1.6 1.9 1 0 0 1 1 1 0 Associated with HOX SET_assoc PF11767.8 EDN02618.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated pP_pnuc_1 PF18165.1 EDN02618.1 - 0.15 11.9 1.5 0.39 10.6 1.5 1.6 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease Pkinase_fungal PF17667.1 EDN02619.1 - 4.4e-74 249.7 0.1 1.4e-57 195.4 0.0 3.1 1 1 2 3 3 3 3 Fungal protein kinase Pkinase PF00069.25 EDN02619.1 - 9.6e-07 28.4 0.0 1.7e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APG5 PF04106.12 EDN02620.1 - 0.033 13.8 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg5 XRN_M PF17846.1 EDN02621.1 - 4.2e-103 345.7 3.0 8.5e-103 344.7 3.0 1.4 1 0 0 1 1 1 1 Xrn1 helical domain XRN1_D1 PF18332.1 EDN02621.1 - 7e-78 260.8 0.1 7e-78 260.8 0.1 2.1 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN_N PF03159.18 EDN02621.1 - 4e-47 160.7 1.8 9.1e-47 159.5 0.0 2.3 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus XRN1_D2_D3 PF18334.1 EDN02621.1 - 8e-32 109.3 0.6 2.2e-31 107.9 0.0 2.2 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EDN02621.1 - 1.8e-23 82.4 0.3 5.2e-23 80.9 0.3 1.9 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EDN02621.1 - 1.1e-08 35.1 0.1 2.3e-08 34.0 0.1 1.6 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 Peptidase_C92 PF05708.12 EDN02621.1 - 0.024 14.8 0.2 0.067 13.3 0.2 1.7 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF1345 PF07077.11 EDN02621.1 - 0.16 11.6 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) CAF1C_H4-bd PF12265.8 EDN02622.1 - 4.7e-28 97.2 1.5 1.8e-27 95.4 1.4 2.0 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDN02622.1 - 6.8e-26 90.0 8.1 5.9e-05 23.7 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN02622.1 - 5e-07 29.9 1.4 0.0037 17.5 0.1 4.2 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF3751 PF12571.8 EDN02622.1 - 0.052 13.6 0.0 1 9.5 0.0 2.3 2 0 0 2 2 2 0 Phage tail-collar fibre protein GTP_cyclohydroI PF01227.22 EDN02623.1 - 1.1e-72 243.2 0.1 1.6e-72 242.6 0.1 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EDN02623.1 - 0.018 15.2 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 QueF-like protein Pkinase PF00069.25 EDN02626.1 - 1.6e-72 244.1 0.0 2e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02626.1 - 7.1e-35 120.5 0.0 1.2e-34 119.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN02626.1 - 2.8e-05 23.6 0.8 0.0012 18.2 0.0 2.7 1 1 2 3 3 3 1 Kinase-like Kdo PF06293.14 EDN02626.1 - 0.00021 20.7 0.3 0.00048 19.6 0.3 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDN02626.1 - 0.0021 17.1 0.1 0.068 12.1 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EDN02626.1 - 0.0037 17.2 1.2 0.14 12.1 0.1 2.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN02626.1 - 0.0063 15.3 0.0 0.011 14.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 EDN02626.1 - 0.15 11.7 0.1 0.24 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 NUDIX PF00293.28 EDN02627.1 - 3e-18 66.1 0.4 5.3e-18 65.3 0.4 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EDN02627.1 - 4.8e-13 49.6 0.0 2.4e-12 47.4 0.0 2.0 2 1 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EDN02627.1 - 0.00025 20.6 1.3 0.00048 19.7 1.3 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Pkinase PF00069.25 EDN02628.1 - 6.6e-09 35.5 0.0 3.2e-06 26.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Dynamin_N PF00350.23 EDN02630.1 - 3.6e-23 82.4 0.0 7.7e-23 81.4 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EDN02630.1 - 5e-18 65.3 0.1 1.2e-16 60.8 0.1 2.7 1 1 1 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EDN02630.1 - 3.3e-06 27.2 0.0 9.3e-06 25.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EDN02630.1 - 0.011 15.5 0.3 1 9.0 0.0 3.1 4 0 0 4 4 4 0 AAA ATPase domain GED PF02212.18 EDN02630.1 - 0.014 15.5 1.3 0.032 14.4 0.3 2.1 2 0 0 2 2 2 0 Dynamin GTPase effector domain FeoB_N PF02421.18 EDN02630.1 - 0.042 13.4 0.1 0.92 9.0 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B Questin_oxidase PF14027.6 EDN02631.1 - 2.6e-79 267.2 5.5 8e-68 229.5 0.1 2.1 1 1 1 2 2 2 2 Questin oxidase-like NADH5_C PF06455.11 EDN02631.1 - 0.07 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus ERCC3_RAD25_C PF16203.5 EDN02632.1 - 3.1e-123 409.8 0.3 4.8e-123 409.2 0.3 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EDN02632.1 - 2.3e-33 115.0 0.0 6.2e-33 113.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN02632.1 - 2.9e-16 59.9 0.0 5.7e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDN02632.1 - 5.7e-14 52.4 0.1 1.4e-13 51.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EDN02632.1 - 9.8e-10 37.7 0.0 1.2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 EDN02632.1 - 5.5e-05 23.0 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 EDN02632.1 - 0.00042 19.3 0.0 0.00073 18.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 SBP_bac_6 PF13343.6 EDN02632.1 - 0.16 11.4 0.0 1 8.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein DUF4748 PF15932.5 EDN02633.1 - 1.3e-18 66.4 0.1 2.4e-18 65.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) PNP_UDP_1 PF01048.20 EDN02634.1 - 8e-11 41.6 0.0 2.4e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EDN02634.1 - 1.2e-06 28.5 0.0 2.8e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EDN02634.1 - 3.2e-06 27.5 0.0 7.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN02634.1 - 0.00011 22.7 0.1 0.00057 20.3 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain ATPase PF06745.13 EDN02634.1 - 0.029 13.7 0.6 0.16 11.3 0.3 2.3 1 1 0 1 1 1 0 KaiC AAA PF00004.29 EDN02634.1 - 0.034 14.6 0.2 0.36 11.2 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EDN02634.1 - 0.086 12.1 0.0 0.25 10.5 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Myb_DNA-bind_6 PF13921.6 EDN02635.1 - 0.058 13.7 4.3 0.16 12.2 4.3 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Pkinase PF00069.25 EDN02636.1 - 1.1e-08 34.7 0.0 1.3e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02636.1 - 4.3e-08 32.8 0.0 4.9e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Astro_capsid_p PF12226.8 EDN02637.1 - 9.1e-05 21.8 3.4 0.00012 21.3 3.4 1.1 1 0 0 1 1 1 1 Turkey astrovirus capsid protein Na_trans_assoc PF06512.13 EDN02637.1 - 0.022 15.0 1.9 0.025 14.9 1.9 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated CDC45 PF02724.14 EDN02637.1 - 0.078 11.3 1.0 0.089 11.1 1.0 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 EDN02637.1 - 0.15 11.3 1.5 0.19 10.9 1.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sporozoite_P67 PF05642.11 EDN02637.1 - 0.18 9.9 1.2 0.21 9.7 1.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 EDN02637.1 - 1.1 7.3 10.0 1.4 7.0 10.0 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 EDN02637.1 - 6.2 5.8 13.4 8.7 5.4 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4637 PF15470.6 EDN02637.1 - 8.6 6.1 11.3 14 5.4 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DDE_1 PF03184.19 EDN02638.1 - 3e-15 56.3 0.0 7.3e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN02638.1 - 0.0017 18.3 0.0 0.0069 16.4 0.0 2.2 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN02638.1 - 0.03 14.0 0.5 0.03 14.0 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN02638.1 - 0.051 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) Borrelia_P83 PF05262.11 EDN02638.1 - 2.3 6.6 20.6 3.8 5.9 20.6 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 EDN02638.1 - 6.2 6.6 14.0 11 5.7 14.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2841 PF11001.8 EDN02640.1 - 8.8e-46 155.0 2.9 2e-45 153.9 2.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) TAF1D PF15333.6 EDN02640.1 - 0.0056 16.5 0.4 0.0056 16.5 0.4 2.1 2 1 1 3 3 3 1 TATA box-binding protein-associated factor 1D Pkinase_fungal PF17667.1 EDN02644.1 - 1.1e-47 162.7 0.0 1.6e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase TPR_10 PF13374.6 EDN02644.1 - 0.11 12.4 0.0 2 8.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3435 PF11917.8 EDN02645.1 - 4.1e-120 401.5 3.3 1.8e-88 297.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) RT_RNaseH PF17917.1 EDN02646.1 - 1.8e-39 134.2 0.4 1.8e-39 134.2 0.4 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN02646.1 - 1.1e-34 118.4 0.0 3.6e-34 116.8 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN02646.1 - 5.3e-28 98.1 0.4 1.1e-27 97.0 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN02646.1 - 3.3e-19 68.7 0.1 7.2e-19 67.6 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN02646.1 - 2e-14 53.8 0.0 5.6e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN02646.1 - 9.6e-13 47.8 0.2 2.6e-12 46.4 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN02646.1 - 5.6e-06 26.5 0.1 2.2e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Tudor-knot PF11717.8 EDN02646.1 - 0.0048 16.8 0.2 0.041 13.8 0.0 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain CENP-T_C PF15511.6 EDN02646.1 - 0.089 12.9 0.2 0.39 10.9 0.2 2.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Asp_protease_2 PF13650.6 EDN02646.1 - 0.19 12.4 0.0 0.38 11.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease CTD_bind PF04818.13 EDN02647.1 - 1.6e-12 48.0 0.1 3.7e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Pkinase PF00069.25 EDN02649.1 - 3.7e-21 75.7 0.0 6.8e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EDN02649.1 - 4.3e-20 72.1 0.7 5.3e-06 26.9 0.0 5.9 3 3 4 7 7 7 6 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EDN02649.1 - 8e-17 61.4 0.0 1.3e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EDN02649.1 - 1.2e-14 54.5 3.6 0.00052 20.5 0.1 6.7 6 2 2 8 8 8 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN02649.1 - 3.1e-08 33.2 18.5 2.9 8.7 0.0 9.4 10 0 0 10 10 10 3 Ankyrin repeat Ank_5 PF13857.6 EDN02649.1 - 2.7e-05 24.4 11.4 2.1 8.8 0.1 6.6 8 1 1 9 9 9 3 Ankyrin repeats (many copies) Kdo PF06293.14 EDN02649.1 - 0.0095 15.3 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.12 EDN02649.1 - 0.0098 16.6 0.8 0.025 15.3 0.8 1.8 1 0 0 1 1 1 1 Sel1 repeat Ank PF00023.30 EDN02649.1 - 0.071 13.6 19.2 4.7 7.8 0.1 7.8 10 0 0 10 10 10 0 Ankyrin repeat Pkinase_fungal PF17667.1 EDN02649.1 - 0.18 10.5 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase HeLo PF14479.6 EDN02650.1 - 1.2e-22 80.8 0.5 1.2e-22 80.8 0.5 1.6 2 0 0 2 2 2 1 Prion-inhibition and propagation Pkinase_Tyr PF07714.17 EDN02650.1 - 0.036 13.3 0.0 0.25 10.6 0.0 2.2 1 1 0 1 1 1 0 Protein tyrosine kinase EMP24_GP25L PF01105.24 EDN02651.1 - 5.8e-45 153.5 0.4 8.6e-45 152.9 0.4 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DEAD PF00270.29 EDN02651.1 - 4.4e-09 36.3 0.0 1.1e-08 35.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN02651.1 - 0.00018 21.6 0.0 0.00034 20.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN02651.1 - 0.08 13.2 0.1 0.28 11.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain USP7_C2 PF14533.6 EDN02652.1 - 4.5e-73 245.4 0.2 4.3e-72 242.2 0.1 2.5 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 EDN02652.1 - 1.2e-70 237.5 0.0 2.8e-36 125.0 0.0 2.7 2 1 1 3 3 3 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 EDN02652.1 - 5.4e-34 117.8 0.3 9e-34 117.1 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN02652.1 - 4.2e-11 43.0 0.0 7.2e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase A_deaminase PF00962.22 EDN02653.1 - 3.8e-18 65.9 0.2 2.2e-17 63.4 0.0 2.0 2 0 0 2 2 2 1 Adenosine/AMP deaminase DUF4491 PF14898.6 EDN02654.1 - 4.1 7.9 6.4 17 5.9 1.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) BCDHK_Adom3 PF10436.9 EDN02655.1 - 1.8e-46 157.9 0.2 3.7e-45 153.7 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDN02655.1 - 0.00056 20.4 0.0 0.0036 17.8 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDN02655.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Herpes_LMP1 PF05297.11 EDN02656.1 - 4.5 6.4 5.9 6.7 5.8 5.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) SPC22 PF04573.12 EDN02657.1 - 1.4e-36 125.6 0.1 1e-26 93.4 0.0 2.1 2 0 0 2 2 2 2 Signal peptidase subunit Peptidase_C48 PF02902.19 EDN02658.1 - 2.8e-31 109.1 0.2 1.5e-30 106.6 0.2 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Nore1-SARAH PF16517.5 EDN02658.1 - 0.22 11.5 1.0 0.73 9.8 1.0 1.9 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain IF4E PF01652.18 EDN02659.1 - 1.8e-55 187.1 0.0 2.7e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E GST_N PF02798.20 EDN02661.1 - 3.2e-07 30.6 0.0 5.3e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDN02661.1 - 1.3e-06 28.8 0.0 2.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDN02661.1 - 0.0002 21.6 0.0 0.00032 20.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDN02661.1 - 0.00073 19.7 0.0 0.0011 19.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDN02661.1 - 0.007 16.6 0.0 0.0097 16.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDN02661.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EDN02661.1 - 0.15 12.3 0.0 0.4 10.9 0.0 1.7 2 0 0 2 2 2 0 Glutaredoxin AMP-binding PF00501.28 EDN02662.1 - 2e-17 62.9 0.0 2.5e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cyclin_C_2 PF16899.5 EDN02662.1 - 0.084 13.3 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Cyclin C-terminal domain Peptidase_M19 PF01244.21 EDN02663.1 - 8.9e-94 314.2 0.0 1.1e-93 314.0 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) POT1 PF02765.17 EDN02664.1 - 1.7e-23 83.0 0.0 4.6e-23 81.6 0.0 1.8 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 FMO-like PF00743.19 EDN02665.1 - 4.3e-47 160.8 0.0 1.2e-23 83.4 0.0 3.0 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDN02665.1 - 7.6e-14 51.7 0.0 1.3e-09 37.7 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN02665.1 - 2.6e-11 43.3 0.0 1.6e-10 40.8 0.0 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN02665.1 - 1.3e-07 31.7 0.2 1.2e-05 25.4 0.6 3.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EDN02665.1 - 2.1e-07 31.1 0.0 5.8e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EDN02665.1 - 2.5e-07 30.2 0.1 0.00013 21.3 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EDN02665.1 - 1e-05 24.9 0.1 0.00036 19.8 0.0 2.2 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EDN02665.1 - 0.00014 21.5 0.0 0.023 14.3 0.0 2.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDN02665.1 - 0.0023 16.7 0.0 0.11 11.1 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 EDN02665.1 - 0.0046 16.3 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Glu_dehyd_C PF16912.5 EDN02665.1 - 0.028 13.9 0.0 6.1 6.3 0.0 2.6 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Pyr_redox PF00070.27 EDN02665.1 - 0.037 14.6 0.0 0.79 10.3 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EDN02665.1 - 0.041 12.7 0.1 0.2 10.4 0.0 1.8 2 0 0 2 2 2 0 MCRA family FAD_binding_3 PF01494.19 EDN02665.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 EDN02665.1 - 0.17 11.0 0.0 8.2 5.4 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain HDA2-3 PF11496.8 EDN02666.1 - 3.3e-39 134.8 0.0 9.5e-38 130.0 0.0 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 IF-2B PF01008.17 EDN02667.1 - 3.7e-22 78.8 0.0 4.8e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Transglut_core PF01841.19 EDN02668.1 - 1.7e-09 38.1 0.0 4.1e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core2 PF13369.6 EDN02668.1 - 0.04 13.5 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like superfamily Angiomotin_C PF12240.8 EDN02668.1 - 0.13 11.8 0.1 0.3 10.6 0.1 1.5 1 0 0 1 1 1 0 Angiomotin C terminal DHHA2 PF02833.14 EDN02669.1 - 1.1e-10 41.9 0.0 2.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EDN02669.1 - 1.9e-06 28.0 0.0 3e-05 24.2 0.0 2.8 2 1 0 2 2 2 1 DHH family PLU-1 PF08429.11 EDN02671.1 - 4.6e-113 377.8 20.3 2.6e-109 365.5 18.6 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EDN02671.1 - 2.2e-44 150.5 0.3 5.5e-44 149.2 0.3 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 EDN02671.1 - 6.7e-21 74.8 0.1 1.6e-20 73.6 0.1 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD PF00628.29 EDN02671.1 - 9.1e-18 63.9 30.5 4.7e-10 39.2 6.5 3.7 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.16 EDN02671.1 - 3.1e-11 43.5 12.4 1e-10 41.8 12.4 2.0 1 0 0 1 1 1 1 C5HC2 zinc finger zf-PHD-like PF15446.6 EDN02671.1 - 0.028 14.1 9.9 0.075 12.6 1.1 2.9 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 EDN02671.1 - 3.7 7.5 22.8 0.74 9.7 1.2 3.9 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Thymidylate_kin PF02223.17 EDN02674.1 - 2.4e-47 161.0 0.0 3e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase KTI12 PF08433.10 EDN02674.1 - 0.00036 20.1 0.0 0.0011 18.5 0.0 1.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.6 EDN02674.1 - 0.011 16.0 0.0 0.02 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDN02674.1 - 0.02 15.4 0.0 0.34 11.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain CPT PF07931.12 EDN02674.1 - 0.053 13.4 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 EDN02674.1 - 0.083 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase TGT PF01702.18 EDN02675.1 - 2.6e-65 220.9 0.0 3.4e-65 220.5 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF2201 PF09967.9 EDN02675.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 VWA-like domain (DUF2201) MFS_1 PF07690.16 EDN02676.1 - 1.1e-37 129.8 22.3 1.4e-37 129.5 22.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EDN02676.1 - 0.017 14.0 0.5 0.017 14.0 0.5 2.6 3 1 0 3 3 3 0 MFS_1 like family OATP PF03137.20 EDN02676.1 - 0.11 10.7 10.1 0.26 9.5 1.0 2.9 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2371 PF10177.9 EDN02676.1 - 0.3 11.3 1.9 1.4 9.1 0.2 2.4 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) MTHFR PF02219.17 EDN02677.1 - 2.7e-95 319.0 0.0 3.8e-95 318.5 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Abhydrolase_3 PF07859.13 EDN02678.1 - 7.1e-53 179.6 0.0 9.6e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EDN02678.1 - 1.1e-08 34.4 0.0 3.1e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family FLILHELTA PF10306.9 EDN02679.1 - 1.4e-29 102.3 0.0 2.1e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA NDK PF00334.19 EDN02680.1 - 6.3e-54 181.6 0.0 7.3e-54 181.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.26 EDN02681.1 - 3.1e-139 465.0 3.6 4.3e-139 464.5 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EDN02681.1 - 6.9e-25 87.2 0.3 2.4e-24 85.4 0.1 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EDN02681.1 - 2.2e-07 31.0 0.2 6.5e-07 29.5 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) PQ-loop PF04193.14 EDN02682.1 - 1.1e-21 76.4 3.7 1.4e-12 47.2 0.3 2.7 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EDN02682.1 - 0.056 14.3 3.1 0.18 12.6 3.1 1.8 1 1 0 1 1 1 0 ER lumen protein retaining receptor NMT1 PF09084.11 EDN02683.1 - 0.0012 18.8 0.0 0.0059 16.6 0.0 1.9 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_3 PF16868.5 EDN02683.1 - 0.0094 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 EDN02683.1 - 0.029 13.8 0.0 0.26 10.7 0.0 2.1 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Tetraspanin PF00335.20 EDN02684.1 - 7.9e-05 22.5 4.7 0.00032 20.5 4.7 1.9 1 1 0 1 1 1 1 Tetraspanin family FtsX PF02687.21 EDN02684.1 - 0.4 11.2 11.4 0.37 11.3 5.0 2.7 3 0 0 3 3 3 0 FtsX-like permease family SPC12 PF06645.13 EDN02684.1 - 6.4 6.9 6.8 2.8 8.1 0.3 2.9 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Ribosomal_L1 PF00687.21 EDN02685.1 - 1.7e-30 106.3 0.4 3.6e-30 105.2 0.3 1.5 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Agglutinin PF07468.11 EDN02685.1 - 0.037 14.2 0.1 0.26 11.5 0.0 2.0 2 0 0 2 2 2 0 Agglutinin domain COG2 PF06148.11 EDN02686.1 - 2.6e-33 114.9 0.4 2.6e-33 114.9 0.4 1.6 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EDN02686.1 - 2.9e-06 27.2 0.2 1e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 Vps51/Vps67 ING PF12998.7 EDN02686.1 - 0.00048 20.7 2.2 0.83 10.3 0.2 2.5 2 1 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding COG5 PF10392.9 EDN02686.1 - 0.0051 17.0 0.2 0.0051 17.0 0.2 2.1 3 0 0 3 3 3 1 Golgi transport complex subunit 5 ParA PF10609.9 EDN02688.1 - 3.4e-70 236.3 4.7 1.3e-43 149.3 0.2 3.1 2 1 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDN02688.1 - 3e-08 33.8 2.0 4.5e-08 33.2 2.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EDN02688.1 - 1.1e-06 28.1 0.1 1e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EDN02688.1 - 9.8e-05 22.3 0.2 0.0012 18.8 0.3 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDN02688.1 - 0.00044 19.9 0.1 0.00087 18.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EDN02688.1 - 0.0013 18.0 0.5 0.0037 16.5 0.5 1.7 1 0 0 1 1 1 1 Anion-transporting ATPase SRP54 PF00448.22 EDN02688.1 - 0.019 14.6 1.0 4.6 6.8 0.2 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EDN02688.1 - 0.02 14.4 3.3 0.062 12.8 0.3 2.4 2 1 1 3 3 3 0 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EDN02688.1 - 0.023 13.7 0.5 0.023 13.7 0.5 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 EDN02688.1 - 0.045 13.7 0.1 0.074 12.9 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase NADHdeh_related PF10125.9 EDN02688.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 NADH dehydrogenase I, subunit N related protein OrfB_Zn_ribbon PF07282.11 EDN02688.1 - 0.25 11.3 1.2 0.55 10.2 1.2 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain AAA_26 PF13500.6 EDN02688.1 - 1.9 8.3 6.5 3.5 7.4 0.6 2.8 2 1 1 3 3 3 0 AAA domain Neisseria_TspB PF05616.13 EDN02688.1 - 2.2 6.7 7.4 3.2 6.1 7.4 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein TOM13 PF08219.11 EDN02689.1 - 1.7e-37 127.2 0.1 2.2e-37 126.9 0.1 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 60KD_IMP PF02096.20 EDN02690.1 - 1.6e-14 54.1 0.0 1.6e-14 54.1 0.0 1.7 2 0 0 2 2 2 1 60Kd inner membrane protein HDV_ag PF01517.18 EDN02690.1 - 0.037 13.8 3.6 0.056 13.2 3.6 1.2 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen SAM_decarbox PF01536.16 EDN02691.1 - 2.8e-101 339.1 0.0 6.6e-57 193.1 0.0 3.0 1 1 2 3 3 3 3 Adenosylmethionine decarboxylase TAF6_C PF07571.13 EDN02692.1 - 1.5e-29 102.2 0.0 3.3e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EDN02692.1 - 7.7e-26 90.1 0.1 1.5e-25 89.1 0.1 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EDN02692.1 - 0.00029 21.2 0.1 0.0007 20.0 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EDN02692.1 - 0.0015 18.6 0.1 0.0039 17.3 0.1 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EDN02692.1 - 0.0025 18.1 0.1 0.008 16.4 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EDN02692.1 - 0.13 12.7 0.1 0.36 11.2 0.1 1.8 1 0 0 1 1 1 0 CENP-S protein CRAL_TRIO PF00650.20 EDN02693.1 - 2.9e-17 62.8 0.1 5e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDN02693.1 - 8.3e-12 45.1 0.1 1.7e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDN02693.1 - 0.0041 17.3 0.0 0.0067 16.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain AMP-binding PF00501.28 EDN02694.1 - 6.7e-13 48.0 0.3 2.3e-09 36.4 0.0 2.0 1 1 1 2 2 2 2 AMP-binding enzyme IPP-2 PF04979.14 EDN02695.1 - 5.6e-22 78.9 6.6 1.7e-21 77.4 6.6 1.8 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF2064 PF09837.9 EDN02697.1 - 0.096 12.5 0.1 0.096 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) CoA_transf_3 PF02515.17 EDN02700.1 - 1.5e-62 211.9 0.0 1.9e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III HAP1_N PF04849.13 EDN02701.1 - 0.0083 15.4 2.6 0.0083 15.4 2.6 3.2 3 0 0 3 3 3 2 HAP1 N-terminal conserved region Filament PF00038.21 EDN02701.1 - 0.012 15.3 3.5 0.012 15.3 3.5 5.2 2 1 2 4 4 4 0 Intermediate filament protein DUF1192 PF06698.11 EDN02701.1 - 0.017 15.2 2.5 0.017 15.2 2.5 7.3 7 2 1 8 8 8 0 Protein of unknown function (DUF1192) LPP PF04728.13 EDN02701.1 - 0.19 12.2 0.0 0.19 12.2 0.0 7.2 4 2 3 7 7 7 0 Lipoprotein leucine-zipper Mce4_CUP1 PF11887.8 EDN02701.1 - 8.5 5.7 10.0 0.65 9.4 0.1 2.7 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative adh_short_C2 PF13561.6 EDN02702.1 - 5.7e-57 193.0 0.3 7.2e-57 192.6 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN02702.1 - 1.8e-46 158.0 0.3 2.2e-46 157.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN02702.1 - 1e-12 48.3 0.6 1.4e-12 47.9 0.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDN02702.1 - 0.015 14.8 0.2 0.053 13.0 0.2 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_hydro_18 PF00704.28 EDN02703.1 - 3.7e-13 49.9 0.0 4.4e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PhoD PF09423.10 EDN02704.1 - 1.5e-35 122.9 0.0 5.3e-35 121.1 0.0 1.8 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 EDN02704.1 - 0.003 18.1 0.0 0.0082 16.7 0.0 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 EDN02704.1 - 0.015 15.8 0.0 0.035 14.6 0.0 1.6 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain SRP54 PF00448.22 EDN02706.1 - 1.3e-73 246.8 2.0 1.9e-73 246.3 2.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EDN02706.1 - 4.1e-18 65.4 0.1 9.4e-18 64.2 0.1 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EDN02706.1 - 1.7e-07 31.0 0.3 7.4e-07 28.9 0.3 2.1 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EDN02706.1 - 3.2e-06 27.4 0.2 8.4e-06 26.0 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EDN02706.1 - 5.3e-06 26.9 0.1 1.5e-05 25.5 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN02706.1 - 6.5e-06 26.6 0.2 1.7e-05 25.3 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 EDN02706.1 - 2e-05 23.7 0.3 0.00011 21.3 0.3 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EDN02706.1 - 0.00012 21.4 0.0 0.00021 20.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 EDN02706.1 - 0.00082 19.3 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 EDN02706.1 - 0.0011 18.7 0.6 0.0024 17.6 0.6 1.7 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 EDN02706.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 EDN02706.1 - 0.0013 18.6 0.3 0.019 14.9 0.0 2.5 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 EDN02706.1 - 0.0015 18.8 0.0 0.004 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDN02706.1 - 0.0017 18.4 0.4 0.0035 17.4 0.4 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ATP_bind_1 PF03029.17 EDN02706.1 - 0.0027 17.5 0.1 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Thymidylate_kin PF02223.17 EDN02706.1 - 0.005 16.5 0.2 0.022 14.4 0.0 2.1 3 0 0 3 3 2 1 Thymidylate kinase SRP_SPB PF02978.19 EDN02706.1 - 0.0067 17.0 0.1 0.22 12.2 0.0 2.6 2 0 0 2 2 2 1 Signal peptide binding domain AAA_28 PF13521.6 EDN02706.1 - 0.0072 16.6 0.1 0.016 15.5 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EDN02706.1 - 0.0077 16.8 0.1 0.017 15.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain 6PF2K PF01591.18 EDN02706.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MMR_HSR1 PF01926.23 EDN02706.1 - 0.022 14.8 0.2 0.13 12.4 0.1 2.3 2 1 0 2 2 1 0 50S ribosome-binding GTPase AAA_19 PF13245.6 EDN02706.1 - 0.033 14.5 0.2 0.063 13.6 0.2 1.4 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 EDN02706.1 - 0.05 12.5 0.1 0.13 11.1 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.6 EDN02706.1 - 0.053 13.2 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EDN02706.1 - 0.068 13.1 0.2 0.9 9.4 0.0 2.2 1 1 1 2 2 2 0 AAA domain MipZ PF09140.11 EDN02706.1 - 0.087 12.1 0.4 2.3 7.4 0.4 2.3 1 1 0 1 1 1 0 ATPase MipZ Arf PF00025.21 EDN02706.1 - 0.12 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family ABC_tran PF00005.27 EDN02706.1 - 0.12 12.9 0.0 0.26 11.8 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 EDN02706.1 - 0.13 11.8 0.2 0.44 10.1 0.0 2.0 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EDN02706.1 - 0.13 12.6 0.3 0.3 11.5 0.3 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EDN02706.1 - 0.15 12.0 0.1 0.81 9.6 0.0 2.1 2 0 0 2 2 2 0 NTPase SRPRB PF09439.10 EDN02706.1 - 0.17 11.3 0.7 1.5 8.2 0.1 2.1 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit Rrp15p PF07890.12 EDN02707.1 - 4.2e-25 88.6 18.3 3.5e-24 85.7 18.3 2.1 1 1 0 1 1 1 1 Rrp15p DUF2799 PF10973.8 EDN02707.1 - 0.37 11.2 1.6 10 6.6 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2799) Fer2 PF00111.27 EDN02708.1 - 1.4e-13 50.6 0.6 1.8e-13 50.2 0.6 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Mito_carr PF00153.27 EDN02709.1 - 1.8e-07 31.0 2.9 0.14 12.1 0.0 4.7 3 2 0 3 3 3 3 Mitochondrial carrier protein K_channel_TID PF07941.11 EDN02710.1 - 0.016 15.6 1.6 0.031 14.7 1.6 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Methyltransf_24 PF13578.6 EDN02711.1 - 1.2e-11 45.6 0.0 1.9e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 EDN02711.1 - 9.6e-05 21.6 0.0 0.00044 19.5 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase DUF2089 PF09862.9 EDN02711.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) CmcI PF04989.12 EDN02711.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Cephalosporin hydroxylase ADH_N PF08240.12 EDN02712.1 - 4.5e-28 97.3 1.3 1.1e-27 96.1 1.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 EDN02712.1 - 3.4e-06 26.9 0.3 3.4e-06 26.9 0.3 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 EDN02712.1 - 0.0088 16.0 0.3 0.072 13.1 0.0 2.5 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Hid1 PF12722.7 EDN02715.1 - 1e-94 318.3 0.0 1.2e-94 318.1 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein NPCC PF08058.11 EDN02715.1 - 1.5e-23 83.3 0.0 1.8e-15 57.1 0.0 2.5 1 1 1 2 2 2 2 Nuclear pore complex component Dymeclin PF09742.9 EDN02715.1 - 2.5e-23 82.4 0.0 3e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 EDN02716.1 - 0.14 10.3 0.0 0.14 10.3 0.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GDPD_2 PF13653.6 EDN02717.1 - 0.085 13.3 0.5 0.25 11.8 0.2 2.0 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Cupin_2 PF07883.11 EDN02718.1 - 4.5e-08 32.7 0.0 6.8e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EDN02718.1 - 0.098 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) APH PF01636.23 EDN02719.1 - 1.2e-10 41.7 0.0 3e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN02719.1 - 0.015 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase PFL-like PF02901.15 EDN02720.1 - 0.0082 14.8 2.0 0.0094 14.6 1.5 1.3 1 1 0 1 1 1 1 Pyruvate formate lyase-like DUF3746 PF12562.8 EDN02720.1 - 0.32 10.9 1.8 0.48 10.4 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3746) HAT_KAT11 PF08214.11 EDN02721.1 - 9.8e-107 357.3 0.0 1.3e-106 356.9 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein FMO-like PF00743.19 EDN02723.1 - 5.3e-11 41.6 0.0 7.1e-10 37.9 0.0 2.0 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EDN02723.1 - 8.8e-09 34.9 0.0 1.3e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EDN02723.1 - 8.3e-08 31.8 0.0 3.8e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN02723.1 - 0.00073 18.8 0.0 0.002 17.4 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Hydrolase_3 PF08282.12 EDN02724.1 - 0.0012 18.6 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_transf_21 PF13506.6 EDN02726.1 - 2e-12 46.9 0.0 4e-06 26.4 0.0 3.4 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EDN02726.1 - 3.8e-06 26.9 0.0 1.9e-05 24.6 0.0 2.0 3 0 0 3 3 3 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDN02726.1 - 0.0016 18.3 0.1 0.0061 16.4 0.1 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 2 Hum_adeno_E3A PF05393.11 EDN02726.1 - 5.4 7.1 6.4 0.65 10.0 2.0 1.7 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein Ank_2 PF12796.7 EDN02727.1 - 2.7e-11 43.9 0.2 3.3e-10 40.4 0.2 2.5 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN02727.1 - 1.2e-08 35.3 0.0 1.6e-07 31.7 0.0 2.7 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EDN02727.1 - 5.9e-08 32.8 0.9 1.4e-05 25.3 0.4 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EDN02727.1 - 1.1e-06 28.5 0.9 0.00024 21.3 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EDN02727.1 - 5.9e-06 26.5 1.5 1.2e-05 25.4 0.6 2.1 2 1 0 2 2 2 1 Ankyrin repeats (many copies) WW PF00397.26 EDN02728.1 - 7.7e-07 29.1 1.1 1.9e-06 27.8 1.1 1.7 1 0 0 1 1 1 1 WW domain PGP_phosphatase PF09419.10 EDN02729.1 - 0.055 13.1 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Sensor_TM1 PF13755.6 EDN02729.1 - 0.09 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain FAD_binding_2 PF00890.24 EDN02729.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 1 0 1 1 1 0 FAD binding domain DUF1464 PF07318.12 EDN02729.1 - 0.2 10.8 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) Hydrophobin PF01185.18 EDN02730.1 - 1.1e-12 48.4 10.6 1.4e-12 48.0 10.6 1.2 1 0 0 1 1 1 1 Fungal hydrophobin NMO PF03060.15 EDN02731.1 - 2.1e-56 191.8 0.9 4.9e-55 187.2 0.9 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDN02731.1 - 3.1e-13 49.4 0.2 1.9e-11 43.6 0.2 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EDN02731.1 - 0.0007 18.7 0.7 0.0012 17.9 0.7 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EDN02731.1 - 0.099 11.8 0.7 0.2 10.7 0.7 1.6 1 1 0 1 1 1 0 Conserved region in glutamate synthase DUF1729 PF08354.10 EDN02731.1 - 0.15 10.9 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Sdh_cyt PF01127.22 EDN02732.1 - 7.8e-24 84.0 3.1 1e-23 83.6 3.1 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ribonucleas_3_3 PF14622.6 EDN02733.1 - 2.3e-26 92.4 0.1 4.4e-26 91.5 0.1 1.4 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EDN02733.1 - 4.6e-05 24.0 0.1 0.0001 22.9 0.1 1.6 1 1 0 1 1 1 1 Ribonuclease III domain Adap_comp_sub PF00928.21 EDN02734.1 - 8.1e-92 307.3 0.0 1.6e-91 306.3 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDN02734.1 - 8.6e-08 32.2 0.6 1.4e-07 31.5 0.6 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EDN02734.1 - 0.12 11.8 0.0 0.28 10.6 0.0 1.5 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain Sin3_corepress PF08295.12 EDN02737.1 - 0.14 12.2 0.1 0.23 11.6 0.1 1.3 1 0 0 1 1 1 0 Sin3 family co-repressor Amidoligase_2 PF12224.8 EDN02738.1 - 0.037 13.7 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme Peptidase_M18 PF02127.15 EDN02739.1 - 3.6e-139 464.3 0.0 4.1e-139 464.1 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EDN02739.1 - 0.03 13.4 0.4 3.3 6.6 0.0 2.4 3 0 0 3 3 3 0 M42 glutamyl aminopeptidase NOB1_Zn_bind PF08772.11 EDN02740.1 - 2.5e-31 107.6 3.0 4.1e-31 107.0 3.0 1.3 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EDN02740.1 - 2.9e-29 101.4 0.1 1e-28 99.7 0.0 2.0 2 0 0 2 2 2 1 PIN domain of ribonuclease WRNPLPNID PF15017.6 EDN02740.1 - 0.0026 18.6 7.2 0.0044 17.8 4.2 2.4 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box zf-NADH-PPase PF09297.11 EDN02740.1 - 0.02 14.6 0.6 0.02 14.6 0.6 1.9 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.19 EDN02740.1 - 0.023 14.7 0.4 0.25 11.4 0.2 2.4 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 EDN02740.1 - 0.32 11.2 3.2 0.29 11.3 1.2 2.0 2 0 0 2 2 2 0 Zinc ribbon domain LsmAD PF06741.13 EDN02740.1 - 0.57 10.8 5.1 9.8 6.8 3.9 2.7 2 0 0 2 2 2 0 LsmAD domain Nop10p PF04135.12 EDN02741.1 - 9.4e-22 76.8 0.6 1.1e-21 76.5 0.6 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DR2241 PF18069.1 EDN02741.1 - 0.11 12.3 0.1 0.11 12.3 0.1 1.0 1 0 0 1 1 1 0 DR2241 stabilising domain tRNA_int_endo PF01974.17 EDN02742.1 - 1.1e-18 67.1 0.3 4.7e-18 65.0 0.3 2.1 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EDN02742.1 - 3.1e-05 23.5 0.0 7.4e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Tudor_3 PF18115.1 EDN02743.1 - 3.9e-18 65.0 0.0 8.4e-18 64.0 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Rad9_Rad53_bind PF08605.10 EDN02743.1 - 4.7e-14 52.7 0.0 9.3e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT_2 PF16589.5 EDN02743.1 - 7.1e-08 32.8 0.0 1.7e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EDN02743.1 - 2e-07 31.2 0.0 5.1e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTX_C PF08339.10 EDN02743.1 - 0.15 12.1 0.1 6.9 6.7 0.0 2.5 2 0 0 2 2 2 0 RTX C-terminal domain RTT107_BRCT_5 PF16770.5 EDN02743.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Ribosomal_L27 PF01016.19 EDN02744.1 - 2.2e-29 101.3 1.2 3.4e-29 100.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal L27 protein Scramblase PF03803.15 EDN02746.1 - 4.5e-54 183.1 0.0 3.2e-29 101.8 0.0 3.1 1 1 0 2 2 2 2 Scramblase Sporozoite_P67 PF05642.11 EDN02746.1 - 3.6 5.6 8.8 0.42 8.6 2.8 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen UQ_con PF00179.26 EDN02747.1 - 1.8e-49 167.0 0.0 2.1e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TP6A_N PF04406.14 EDN02748.1 - 1e-20 73.5 0.0 1.9e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SQHop_cyclase_C PF13243.6 EDN02749.1 - 1.3e-47 162.4 2.5 3.5e-46 157.8 3.8 2.1 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EDN02749.1 - 1.5e-43 149.0 4.5 1.1e-37 129.7 1.4 3.8 3 1 1 4 4 4 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EDN02749.1 - 6.1e-33 112.2 1.9 1.2e-09 37.7 0.3 5.2 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EDN02749.1 - 4.4e-05 22.6 0.2 0.01 14.9 0.2 3.1 1 1 1 3 3 3 1 A-macroglobulin TED domain Pec_lyase PF09492.10 EDN02749.1 - 0.0018 17.7 0.1 0.7 9.2 0.0 3.7 2 1 2 4 4 4 1 Pectic acid lyase SGS PF05002.15 EDN02750.1 - 6.9e-29 99.8 9.0 4.7e-27 93.9 9.0 2.9 1 1 0 1 1 1 1 SGS domain CS PF04969.16 EDN02750.1 - 4.4e-15 56.5 0.1 8.8e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 CS domain GEMIN8 PF15348.6 EDN02750.1 - 0.016 15.5 0.6 0.028 14.7 0.6 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 DUF2057 PF09829.9 EDN02750.1 - 0.019 15.2 6.6 0.29 11.3 2.9 3.1 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) CDC27 PF09507.10 EDN02750.1 - 0.038 13.4 14.2 0.071 12.5 14.2 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hamartin PF04388.12 EDN02750.1 - 0.9 8.1 6.7 1.2 7.7 6.7 1.2 1 0 0 1 1 1 0 Hamartin protein Acetyltransf_10 PF13673.7 EDN02751.1 - 1.9e-06 27.9 0.0 3.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN02751.1 - 5.4e-05 23.4 0.0 8.3e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN02751.1 - 0.00014 22.2 0.0 0.00021 21.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Amidohydro_3 PF07969.11 EDN02751.1 - 0.037 13.5 0.0 0.044 13.3 0.0 1.0 1 0 0 1 1 1 0 Amidohydrolase family tRNA-synt_1e PF01406.19 EDN02752.1 - 1.3e-113 379.4 0.0 1.7e-113 378.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EDN02752.1 - 0.00023 20.0 0.5 0.22 10.2 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EDN02752.1 - 0.012 16.1 0.0 0.028 14.9 0.0 1.7 1 0 0 1 1 1 0 DALR domain GCD14 PF08704.10 EDN02753.1 - 6.7e-61 206.1 0.0 1e-59 202.2 0.0 2.5 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 EDN02753.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term TPR_2 PF07719.17 EDN02754.1 - 1.2e-06 28.2 0.2 0.31 11.3 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 EDN02754.1 - 8.5e-06 25.6 0.0 2.6e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain TPR_1 PF00515.28 EDN02754.1 - 3.3e-05 23.5 0.1 1.9 8.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN02754.1 - 0.00034 20.9 0.2 0.0067 16.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN02754.1 - 0.0016 19.0 6.1 0.029 15.0 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN02754.1 - 0.096 13.2 2.7 1.5 9.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN02754.1 - 0.15 12.9 3.7 9 7.4 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1688 PF07958.11 EDN02755.1 - 4.1e-179 595.7 0.0 4.7e-179 595.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Gtr1_RagA PF04670.12 EDN02756.1 - 1.8e-49 168.2 1.3 1.1e-26 93.7 0.2 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDN02756.1 - 3.1e-06 27.2 0.0 4.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EDN02756.1 - 0.0015 18.8 0.1 0.0027 17.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN02756.1 - 0.0025 17.3 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_29 PF13555.6 EDN02756.1 - 0.008 15.9 0.5 0.039 13.7 0.2 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.13 EDN02756.1 - 0.016 14.3 0.1 0.027 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 EDN02756.1 - 0.017 15.6 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AIG1 PF04548.16 EDN02756.1 - 0.078 12.3 0.1 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 AIG1 family AAA_7 PF12775.7 EDN02756.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EDN02756.1 - 0.15 12.0 0.4 0.45 10.4 0.0 1.9 2 1 0 2 2 2 0 RsgA GTPase G-alpha PF00503.20 EDN02756.1 - 0.61 9.2 2.1 2 7.5 0.9 2.1 1 1 1 2 2 2 0 G-protein alpha subunit AA_permease PF00324.21 EDN02757.1 - 7.5e-124 413.9 34.8 8.6e-124 413.7 34.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDN02757.1 - 2.2e-33 115.8 36.5 2.6e-33 115.5 36.5 1.1 1 0 0 1 1 1 1 Amino acid permease RdRP PF05183.12 EDN02758.1 - 3e-105 353.1 0.0 6.2e-58 196.9 0.0 2.1 1 1 1 2 2 2 2 RNA dependent RNA polymerase Abhydrolase_6 PF12697.7 EDN02759.1 - 6.1e-14 53.1 3.6 1.4e-11 45.5 3.6 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family BNR_2 PF13088.6 EDN02760.1 - 8.6e-06 25.2 0.9 0.048 13.0 0.9 3.2 1 1 2 3 3 3 2 BNR repeat-like domain BNR_3 PF13859.6 EDN02760.1 - 0.0062 15.9 0.2 0.021 14.1 0.2 1.8 1 1 0 1 1 1 1 BNR repeat-like domain Sortilin-Vps10 PF15902.5 EDN02760.1 - 0.026 13.3 0.6 1.3 7.7 0.2 2.0 1 1 1 2 2 2 0 Sortilin, neurotensin receptor 3, BNR PF02012.20 EDN02760.1 - 0.3 11.3 16.2 1.8 8.9 1.3 4.6 4 0 0 4 4 4 0 BNR/Asp-box repeat Opi1 PF08618.10 EDN02761.1 - 7e-49 167.2 16.1 2.6e-34 119.2 4.8 3.3 1 1 2 3 3 3 3 Transcription factor Opi1 adh_short_C2 PF13561.6 EDN02762.1 - 5.6e-54 183.2 4.6 1.3e-53 181.9 4.6 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN02762.1 - 6.8e-32 110.5 3.7 5.5e-31 107.6 3.7 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN02762.1 - 1.5e-07 31.5 2.0 1.6e-06 28.1 2.0 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EDN02762.1 - 0.00034 20.2 0.4 1.2 8.5 0.0 2.9 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family Mrr_cat PF04471.12 EDN02762.1 - 0.11 12.5 0.3 0.26 11.3 0.1 1.7 2 0 0 2 2 2 0 Restriction endonuclease Shikimate_DH PF01488.20 EDN02762.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Voldacs PF03517.13 EDN02764.1 - 3e-34 118.1 1.6 5.1e-34 117.4 1.6 1.4 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling PRIMA1 PF16101.5 EDN02764.1 - 2.6 8.1 7.9 0.25 11.4 3.3 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Peroxidase_2 PF01328.17 EDN02765.1 - 1.7e-19 71.1 0.0 1.7e-19 71.1 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 DUF2235 PF09994.9 EDN02766.1 - 2.9e-45 154.8 5.5 1.5e-22 80.3 2.9 2.1 1 1 0 2 2 2 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) p450 PF00067.22 EDN02767.1 - 2.7e-12 46.2 0.0 7.4e-12 44.8 0.0 1.8 3 0 0 3 3 3 1 Cytochrome P450 An_peroxidase PF03098.15 EDN02767.1 - 1.2e-08 34.1 0.0 1.4e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 Animal haem peroxidase GerE PF00196.19 EDN02767.1 - 0.06 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_38 PF13936.6 EDN02767.1 - 0.085 12.6 0.1 0.36 10.6 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Fur_reg_FbpA PF13076.6 EDN02767.1 - 0.089 12.5 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Fur-regulated basic protein A Metallophos PF00149.28 EDN02769.1 - 1.3e-30 107.5 0.0 2.5e-30 106.5 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 EDN02769.1 - 0.3 10.9 1.8 3.2 7.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Peptidase_S8 PF00082.22 EDN02771.1 - 4.2e-40 137.9 5.8 7.7e-40 137.0 5.7 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDN02771.1 - 1e-18 67.8 0.3 2.1e-18 66.7 0.3 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Beach PF02138.18 EDN02773.1 - 1.4e-53 182.0 0.1 1.9e-53 181.6 0.1 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 EDN02773.1 - 6.8e-09 36.2 5.5 0.0007 20.4 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat TAL_FSA PF00923.19 EDN02774.1 - 2.8e-94 315.7 0.2 3.2e-94 315.5 0.2 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase DUF4246 PF14033.6 EDN02775.1 - 3.5e-169 563.7 0.0 4.3e-169 563.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_3 PF13640.6 EDN02775.1 - 0.031 15.2 0.0 0.072 14.0 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Sod_Cu PF00080.20 EDN02778.1 - 1.2e-48 164.9 5.2 1.3e-48 164.7 5.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DDE_1 PF03184.19 EDN02779.1 - 1.2e-30 106.5 0.0 1.4e-29 103.0 0.0 2.5 3 0 0 3 3 3 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN02779.1 - 0.0025 17.6 0.0 0.0065 16.2 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Fungal_trans PF04082.18 EDN02780.1 - 4.8e-10 38.9 0.1 8.9e-10 38.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain IL34 PF15036.6 EDN02780.1 - 0.16 12.0 0.9 0.36 10.9 0.1 1.8 2 0 0 2 2 2 0 Interleukin 34 DUF2855 PF11017.8 EDN02781.1 - 4.8e-19 69.3 0.2 1.4e-12 48.1 0.2 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF2855) SNase PF00565.17 EDN02782.1 - 4.2e-80 265.3 3.6 6.6e-26 90.9 0.0 5.8 6 0 0 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EDN02782.1 - 7e-28 97.1 0.0 1.7e-27 95.9 0.0 1.7 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 EDN02782.1 - 0.0072 16.8 0.3 0.034 14.6 0.1 2.4 2 0 0 2 2 2 1 Agenet domain SMN PF06003.12 EDN02782.1 - 0.017 14.4 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF3297 PF11730.8 EDN02782.1 - 0.084 12.8 0.1 0.32 10.9 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) CRAL_TRIO PF00650.20 EDN02783.1 - 2.1e-23 82.8 0.0 3.1e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDN02783.1 - 5.6e-09 36.0 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain AT_hook PF02178.19 EDN02784.1 - 9e-05 21.9 49.4 0.091 12.7 6.4 5.7 5 0 0 5 5 5 4 AT hook motif Ndc1_Nup PF09531.10 EDN02784.1 - 3.9 6.0 4.0 4.7 5.8 4.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EphA2_TM PF14575.6 EDN02785.1 - 0.037 14.9 0.0 0.11 13.4 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Trp_oprn_chp PF09534.10 EDN02785.1 - 0.053 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SKG6 PF08693.10 EDN02785.1 - 8.9 5.8 10.2 18 4.8 10.2 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EMC1_C PF07774.13 EDN02786.1 - 2.4e-76 256.1 0.0 5e-76 255.1 0.0 1.6 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EDN02786.1 - 1.3e-26 93.7 8.9 7.6e-23 81.3 0.3 4.0 3 1 0 4 4 4 2 PQQ-like domain PQQ PF01011.21 EDN02786.1 - 3e-10 39.5 4.5 0.0012 18.7 0.2 6.4 7 0 0 7 7 7 2 PQQ enzyme repeat PQQ_3 PF13570.6 EDN02786.1 - 0.055 14.0 1.7 21 5.8 0.0 5.5 6 0 0 6 6 6 0 PQQ-like domain DUF1479 PF07350.12 EDN02787.1 - 1e-167 558.1 0.0 1.2e-167 557.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Baculo_PEP_C PF04513.12 EDN02788.1 - 0.017 15.2 0.0 0.05 13.6 0.0 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RAM PF15320.6 EDN02788.1 - 0.021 15.4 0.1 0.036 14.7 0.1 1.4 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Lipoprotein_7 PF01540.16 EDN02788.1 - 0.025 13.9 0.2 0.027 13.8 0.2 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein Apolipoprotein PF01442.18 EDN02788.1 - 0.029 14.3 2.5 0.067 13.1 2.5 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Nbl1_Borealin_N PF10444.9 EDN02788.1 - 0.031 13.9 2.5 0.11 12.1 2.1 2.2 2 1 0 2 2 2 0 Nbl1 / Borealin N terminal Syntaxin_2 PF14523.6 EDN02788.1 - 0.05 14.0 0.9 0.093 13.1 0.9 1.5 1 0 0 1 1 1 0 Syntaxin-like protein DUF883 PF05957.13 EDN02788.1 - 0.078 13.6 0.4 0.24 12.0 0.1 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4129 PF13559.6 EDN02788.1 - 0.081 13.2 0.4 0.49 10.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) tRNA-synt_1e PF01406.19 EDN02788.1 - 0.093 12.1 1.3 0.11 11.8 1.3 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DUF1978 PF09321.10 EDN02788.1 - 0.11 11.7 5.1 0.59 9.4 1.5 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF1978) Fib_alpha PF08702.10 EDN02788.1 - 0.13 12.4 0.9 0.24 11.6 0.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 EDN02788.1 - 0.14 12.6 2.6 11 6.5 0.0 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 EDN02788.1 - 0.23 12.0 4.0 0.54 10.8 4.0 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 PKcGMP_CC PF16808.5 EDN02788.1 - 0.31 10.9 4.1 0.97 9.3 2.6 2.5 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Aa_trans PF01490.18 EDN02789.1 - 2.1e-80 270.4 23.8 4.2e-80 269.5 23.8 1.4 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_9_N PF15420.6 EDN02789.1 - 0.012 15.6 1.8 0.012 15.6 1.8 3.3 4 1 0 4 4 4 0 Alpha/beta-hydrolase family N-terminus Bax1-I PF01027.20 EDN02790.1 - 7.6e-24 84.7 11.8 3.5e-17 62.9 6.3 2.0 1 1 1 2 2 2 2 Inhibitor of apoptosis-promoting Bax1 DUF2977 PF11192.8 EDN02790.1 - 0.16 12.1 0.1 0.52 10.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2977) DUF2721 PF11026.8 EDN02790.1 - 1.7 8.6 7.2 0.12 12.2 1.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) UQ_con PF00179.26 EDN02791.1 - 4.7e-28 97.6 0.0 5.8e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SDA1 PF05285.12 EDN02791.1 - 0.14 11.6 12.6 0.17 11.3 12.6 1.1 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 EDN02791.1 - 0.32 10.7 15.9 0.43 10.3 15.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 EDN02791.1 - 0.44 8.8 5.1 0.42 8.8 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EDN02791.1 - 1.1 8.5 19.5 1.4 8.2 19.5 1.1 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 EDN02791.1 - 1.3 7.1 13.4 1.6 6.9 13.4 1.1 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 EDN02791.1 - 3.1 7.8 14.3 4.5 7.3 14.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein ABC_tran PF00005.27 EDN02792.1 - 2.5e-52 177.1 0.0 1.1e-30 106.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDN02792.1 - 8.6e-48 163.3 22.9 5e-32 111.6 4.4 3.9 3 1 1 4 4 4 2 ABC transporter transmembrane region AAA_23 PF13476.6 EDN02792.1 - 1e-06 29.4 1.2 0.0034 17.9 0.1 3.2 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.19 EDN02792.1 - 1.8e-06 27.6 5.7 0.068 12.6 1.0 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDN02792.1 - 5e-06 26.5 0.7 0.022 14.6 0.1 3.4 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EDN02792.1 - 3.3e-05 23.9 0.1 0.054 13.6 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EDN02792.1 - 0.00015 22.2 0.4 1.4 9.3 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EDN02792.1 - 0.00038 20.1 0.9 0.6 9.9 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN02792.1 - 0.00042 20.3 0.6 0.31 10.9 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase DUF87 PF01935.17 EDN02792.1 - 0.0015 18.7 0.8 0.099 12.7 0.0 2.8 2 0 0 2 2 2 1 Helicase HerA, central domain T2SSE PF00437.20 EDN02792.1 - 0.0034 16.5 0.0 0.06 12.4 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 EDN02792.1 - 0.0034 17.0 0.1 0.43 10.1 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN02792.1 - 0.0036 17.6 1.4 3.7 7.8 0.1 3.4 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EDN02792.1 - 0.023 14.4 0.1 4.8 6.9 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EDN02792.1 - 0.094 12.0 1.5 4.6 6.5 0.2 2.4 2 0 0 2 2 2 0 Zeta toxin Adeno_IVa2 PF02456.15 EDN02792.1 - 0.14 11.0 0.2 0.41 9.4 0.0 1.7 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA PF00004.29 EDN02792.1 - 0.14 12.6 1.3 13 6.3 0.1 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDN02792.1 - 0.14 11.7 0.2 19 4.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EDN02792.1 - 0.17 11.6 0.3 7.3 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EDN02792.1 - 0.18 11.8 2.1 6 6.9 0.1 2.8 2 0 0 2 2 2 0 Dynamin family NACHT PF05729.12 EDN02792.1 - 0.35 10.8 1.3 6.6 6.6 0.2 2.5 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.18 EDN02792.1 - 0.37 10.1 1.0 3 7.1 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.6 EDN02792.1 - 0.44 11.1 1.6 28 5.3 0.2 2.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDN02792.1 - 0.52 9.9 2.7 0.63 9.6 0.4 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_12 PF13087.6 EDN02793.1 - 4e-29 101.7 0.0 6e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDN02793.1 - 0.0068 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DUF640 PF04852.12 EDN02793.1 - 0.062 13.5 0.9 0.38 10.9 1.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF640) Baculo_8kDa PF06096.11 EDN02793.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein AAA_11 PF13086.6 EDN02794.1 - 2.4e-13 50.5 0.0 2.7e-12 47.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDN02794.1 - 1.4e-07 31.5 0.0 6e-07 29.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDN02794.1 - 5.5e-06 26.8 0.0 8.1e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDN02794.1 - 0.0032 17.5 0.0 0.0076 16.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EDN02794.1 - 0.0039 16.7 0.0 0.014 14.8 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein DEAD PF00270.29 EDN02794.1 - 0.0075 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EDN02794.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EDN02794.1 - 0.12 12.1 0.1 0.76 9.5 0.0 2.3 3 0 0 3 3 3 0 IstB-like ATP binding protein RuvB_N PF05496.12 EDN02794.1 - 0.14 11.9 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain WD40 PF00400.32 EDN02795.1 - 1.1e-11 45.1 9.1 0.77 10.7 0.4 6.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN02795.1 - 0.018 15.3 0.1 12 6.3 0.0 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PRP38 PF03371.15 EDN02797.1 - 3.8e-64 215.7 0.0 4.9e-64 215.4 0.0 1.0 1 0 0 1 1 1 1 PRP38 family FAD_binding_3 PF01494.19 EDN02798.1 - 4.2e-55 187.4 0.0 6.8e-54 183.4 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EDN02798.1 - 1e-30 107.0 0.0 1.9e-30 106.1 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.10 EDN02798.1 - 0.0091 15.1 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase VSP PF03302.13 EDN02801.1 - 0.00078 18.4 3.2 0.0011 17.9 3.2 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.11 EDN02801.1 - 0.0012 19.0 8.4 0.0023 18.0 8.4 1.5 1 0 0 1 1 1 1 Podoplanin Stevor PF17410.2 EDN02801.1 - 0.01 15.4 0.2 0.014 14.9 0.2 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 EDN02801.1 - 0.033 14.1 1.9 0.074 13.0 1.9 1.6 1 1 0 1 1 1 0 TMEM154 protein family DUF2207 PF09972.9 EDN02801.1 - 0.041 12.6 0.0 0.057 12.2 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Amnionless PF14828.6 EDN02801.1 - 0.13 11.1 0.1 0.16 10.8 0.1 1.1 1 0 0 1 1 1 0 Amnionless Alpha_GJ PF03229.13 EDN02801.1 - 0.14 12.7 6.8 0.24 12.0 6.8 1.4 1 0 0 1 1 1 0 Alphavirus glycoprotein J Vpu PF00558.19 EDN02801.1 - 0.24 11.2 0.3 0.39 10.5 0.3 1.3 1 0 0 1 1 1 0 Vpu protein CYYR1 PF10873.8 EDN02801.1 - 0.6 10.6 8.2 2.9 8.3 8.2 1.9 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 TPPK_C PF12555.8 EDN02801.1 - 1 9.4 3.7 2.2 8.4 3.7 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal Mid2 PF04478.12 EDN02801.1 - 4.6 7.1 11.9 42 3.9 11.9 2.1 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor HNH_2 PF13391.6 EDN02803.1 - 6.8e-14 51.8 0.5 1.3e-13 50.9 0.5 1.5 1 0 0 1 1 1 1 HNH endonuclease GST_C PF00043.25 EDN02804.1 - 2e-07 31.1 0.0 4.7e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDN02804.1 - 6.4e-07 29.3 0.5 1.3e-06 28.3 0.5 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDN02804.1 - 0.0094 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DDOST_48kD PF03345.14 EDN02807.1 - 1.1e-156 521.8 0.0 1.3e-156 521.6 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta ATXN-1_C PF12547.8 EDN02807.1 - 0.098 13.0 0.0 0.46 10.9 0.0 2.2 1 0 0 1 1 1 0 Capicua transcriptional repressor modulator DUF928 PF06051.12 EDN02807.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Tr-sialidase_C PF11052.8 EDN02807.1 - 0.41 10.8 6.3 0.98 9.6 6.3 1.7 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Pet191_N PF10203.9 EDN02808.1 - 1.8e-27 95.4 3.4 2.2e-27 95.1 3.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COBRA PF04833.15 EDN02808.1 - 0.0061 16.5 0.5 0.0085 16.0 0.5 1.2 1 0 0 1 1 1 1 COBRA-like protein CX9C PF16860.5 EDN02808.1 - 0.084 12.9 7.4 1.5 8.9 0.8 2.5 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF126 PF01989.16 EDN02808.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Aconitase X swivel domain Abhydro_lipase PF04083.16 EDN02809.1 - 1.2e-23 82.4 0.0 2.4e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDN02809.1 - 1.5e-23 83.8 0.2 1.3e-22 80.7 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN02809.1 - 0.00015 21.2 0.0 0.051 12.8 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EDN02809.1 - 0.00069 19.3 0.0 0.32 10.6 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Esterase PF00756.20 EDN02809.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative esterase zf-MYND PF01753.18 EDN02810.1 - 3.2e-09 36.7 12.1 6e-09 35.8 12.1 1.5 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 EDN02810.1 - 7.8e-05 22.7 4.7 0.00017 21.6 4.7 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 PolC_DP2 PF03833.13 EDN02810.1 - 0.68 7.7 2.5 0.93 7.3 2.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Ras PF00071.22 EDN02811.1 - 1.9e-37 128.4 0.1 3.1e-36 124.4 0.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDN02811.1 - 2.4e-06 27.8 0.0 0.0002 21.6 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN02811.1 - 0.0035 16.8 0.1 0.007 15.8 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family RhlB PF12300.8 EDN02811.1 - 0.11 12.6 4.8 0.17 12.1 4.8 1.2 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Carboxyl_trans PF01039.22 EDN02812.1 - 3.2e-139 464.8 0.0 3.9e-139 464.5 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Acyl-CoA_dh_1 PF00441.24 EDN02813.1 - 1.5e-40 138.8 1.2 2.5e-40 138.1 1.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDN02813.1 - 1.8e-30 105.9 0.0 3.4e-30 105.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EDN02813.1 - 1.3e-26 92.6 0.1 2.6e-26 91.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EDN02813.1 - 1.5e-16 60.9 0.5 2.5e-16 60.2 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EDN02813.1 - 0.00087 19.0 0.1 0.0028 17.4 0.1 1.8 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal CPSase_L_D2 PF02786.17 EDN02814.1 - 1.3e-73 247.0 0.0 2.5e-73 246.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EDN02814.1 - 7.1e-36 122.6 0.0 2.5e-35 120.9 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 EDN02814.1 - 9.9e-36 122.6 0.0 2.1e-35 121.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 EDN02814.1 - 3.9e-15 55.4 1.6 1.4e-14 53.7 1.6 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EDN02814.1 - 9.7e-10 38.3 0.0 3e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDN02814.1 - 2.6e-08 33.6 0.0 6e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EDN02814.1 - 6.3e-05 22.7 0.3 0.24 11.3 0.0 2.9 2 1 1 3 3 3 2 Biotin-lipoyl like RimK PF08443.11 EDN02814.1 - 0.0042 16.7 0.0 0.013 15.1 0.0 1.8 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EDN02814.1 - 0.0051 16.9 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EDN02814.1 - 0.013 14.8 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 EDN02814.1 - 0.026 14.4 0.1 0.13 12.2 0.1 2.0 2 0 0 2 2 2 0 Glycine cleavage H-protein HlyD_3 PF13437.6 EDN02814.1 - 0.037 14.7 0.2 2 9.2 0.0 3.1 3 0 0 3 3 3 0 HlyD family secretion protein DUF1752 PF08550.10 EDN02815.1 - 1e-09 38.1 4.8 2.4e-09 36.9 4.8 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) VIT1 PF01988.19 EDN02816.1 - 0.13 12.2 2.1 0.15 11.9 2.1 1.1 1 0 0 1 1 1 0 VIT family DUF4175 PF13779.6 EDN02817.1 - 4.9 4.9 10.2 6.5 4.5 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UIM PF02809.20 EDN02818.1 - 0.14 12.1 2.1 0.29 11.1 2.1 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif eIF-5a PF01287.20 EDN02819.1 - 1.9e-05 24.7 0.0 3.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Abhydrolase_6 PF12697.7 EDN02822.1 - 1.3e-14 55.4 0.1 1.6e-14 55.1 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN02822.1 - 1.1e-10 41.6 0.1 4.2e-10 39.7 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN02822.1 - 8e-07 28.6 0.0 1.2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 EDN02822.1 - 0.0068 16.1 0.0 0.008 15.9 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EDN02822.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family SRR1 PF07985.12 EDN02823.1 - 2e-17 62.9 0.0 5.7e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 SRR1 Isochorismatase PF00857.20 EDN02824.1 - 5.4e-38 130.9 0.1 6.1e-38 130.7 0.1 1.0 1 0 0 1 1 1 1 Isochorismatase family Glyco_hydro_17 PF00332.18 EDN02825.1 - 8.2e-09 35.5 2.4 1.2e-05 25.0 0.6 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Tyrosinase PF00264.20 EDN02827.1 - 2e-31 110.0 2.9 7.5e-31 108.1 2.9 1.8 1 1 0 1 1 1 1 Common central domain of tyrosinase DUF1031 PF06275.11 EDN02828.1 - 0.059 13.6 0.4 0.11 12.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1031) DUF4767 PF15983.5 EDN02828.1 - 0.061 13.6 0.0 0.094 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4767) zf-C3H1 PF10650.9 EDN02836.1 - 7.8e-10 38.3 2.4 1.3e-09 37.6 2.4 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain DUF5636 PF18686.1 EDN02836.1 - 0.035 14.3 1.4 0.08 13.1 1.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5636) V_ATPase_I PF01496.19 EDN02836.1 - 1.2 7.0 3.7 2.2 6.1 3.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GvpG PF05120.12 EDN02836.1 - 5.2 7.2 8.8 1.7 8.7 4.7 2.2 2 0 0 2 2 2 0 Gas vesicle protein G Myosin_head PF00063.21 EDN02837.1 - 2.6e-265 881.9 0.0 6.4e-265 880.6 0.0 1.7 1 0 0 1 1 1 1 Myosin head (motor domain) Isy1 PF06246.12 EDN02837.1 - 2.5e-85 286.1 0.3 2.5e-85 286.1 0.3 8.0 4 2 0 4 4 4 1 Isy1-like splicing family Myosin_tail_1 PF01576.19 EDN02837.1 - 1.4e-12 46.3 245.8 1.9e-06 26.0 45.5 6.3 2 2 2 5 5 5 4 Myosin tail Myosin_N PF02736.19 EDN02837.1 - 1.2e-10 41.0 0.1 4.1e-10 39.3 0.0 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EDN02837.1 - 0.14 12.4 0.0 0.14 12.4 0.0 4.7 5 0 0 5 5 5 0 AAA domain BPL_C PF02237.17 EDN02837.1 - 0.16 11.9 0.0 0.48 10.4 0.0 1.9 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain IQ PF00612.27 EDN02837.1 - 0.17 11.8 0.4 0.65 9.9 0.4 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif MMR_HSR1 PF01926.23 EDN02838.1 - 1.8e-13 50.6 0.0 6.5e-13 48.8 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN02838.1 - 5.1e-05 22.8 0.0 9.4e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDN02838.1 - 0.00075 19.4 0.1 0.0019 18.1 0.1 1.7 1 1 0 1 1 1 1 RsgA GTPase IIGP PF05049.13 EDN02838.1 - 0.0095 15.0 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Roc PF08477.13 EDN02838.1 - 0.016 15.5 0.2 0.041 14.1 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EDN02838.1 - 0.031 14.4 0.0 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 Dynamin family MeaB PF03308.16 EDN02838.1 - 0.059 12.3 0.1 0.095 11.7 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EDN02838.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Histidinol_dh PF00815.20 EDN02839.1 - 0.038 13.0 0.0 0.041 12.9 0.0 1.0 1 0 0 1 1 1 0 Histidinol dehydrogenase PI3Ka PF00613.20 EDN02840.1 - 1.7e-57 193.8 0.0 2.7e-57 193.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EDN02840.1 - 1.1e-10 41.8 0.0 5.4e-10 39.5 0.0 2.2 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EDN02840.1 - 0.00073 19.5 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4336 PF14234.6 EDN02842.1 - 6.2e-16 58.5 0.0 5.8e-10 38.9 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) 5-nucleotidase PF06189.12 EDN02842.1 - 0.12 11.3 0.0 0.24 10.3 0.0 1.5 1 1 1 2 2 2 0 5'-nucleotidase Nse4_C PF08743.10 EDN02843.1 - 5.3e-35 119.6 0.0 1.5e-34 118.1 0.0 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EDN02843.1 - 3e-15 56.1 0.8 9.1e-15 54.5 0.3 2.2 2 1 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE YtxH PF12732.7 EDN02843.1 - 0.18 12.4 0.3 0.72 10.4 0.1 2.1 2 0 0 2 2 2 0 YtxH-like protein MARVEL PF01284.23 EDN02844.1 - 1e-15 58.0 6.5 1.3e-15 57.7 6.5 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF2530 PF10745.9 EDN02844.1 - 0.0015 18.7 0.2 0.0015 18.7 0.2 2.5 3 1 0 3 3 3 1 Protein of unknown function (DUF2530) ABC2_membrane_5 PF13346.6 EDN02844.1 - 0.041 13.4 4.8 0.064 12.8 4.8 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Pox_A14 PF05767.12 EDN02844.1 - 0.58 10.3 0.0 0.58 10.3 0.0 2.3 2 1 0 2 2 2 0 Poxvirus virion envelope protein A14 Metallophos PF00149.28 EDN02845.1 - 4.4e-11 43.7 0.1 7.7e-11 42.9 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN02845.1 - 3.3e-06 27.4 0.3 1e-05 25.8 0.3 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ThiF PF00899.21 EDN02846.1 - 1.1e-41 142.8 0.0 1.8e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 EDN02846.1 - 0.0021 18.3 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EDN02846.1 - 0.0042 17.3 1.6 0.068 13.4 1.6 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EDN02846.1 - 0.019 14.6 0.0 0.049 13.2 0.0 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EDN02846.1 - 0.028 14.1 0.1 0.048 13.3 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EDN02846.1 - 0.047 12.9 0.2 0.08 12.2 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Melibiase_2 PF16499.5 EDN02846.1 - 0.073 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Alpha galactosidase A NAD_binding_7 PF13241.6 EDN02846.1 - 0.18 12.3 0.0 0.4 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 EDN02846.1 - 0.19 10.6 0.5 0.78 8.5 0.1 1.9 2 0 0 2 2 2 0 Tryptophan halogenase PAGK PF15284.6 EDN02847.1 - 0.17 11.8 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 Phage-encoded virulence factor Abhydrolase_1 PF00561.20 EDN02848.1 - 1.6e-46 159.0 0.0 9.4e-46 156.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EDN02848.1 - 0.0014 18.4 0.1 0.0037 16.9 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Abhydrolase_2 PF02230.16 EDN02848.1 - 0.24 11.2 0.1 0.46 10.2 0.1 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase IMUP PF15761.5 EDN02849.1 - 0.14 12.8 2.8 0.31 11.7 2.8 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein Pkinase PF00069.25 EDN02850.1 - 2e-61 207.7 0.0 2.5e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02850.1 - 3.9e-33 114.8 0.0 7.2e-33 114.0 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EDN02850.1 - 0.00018 21.5 0.1 0.092 12.7 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN02850.1 - 0.052 12.8 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EDN02850.1 - 0.071 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain ATP-synt_C PF00137.21 EDN02851.1 - 1.2e-07 32.0 10.8 7.5e-06 26.2 0.5 2.2 2 0 0 2 2 2 2 ATP synthase subunit C CNH PF00780.22 EDN02852.1 - 3.1e-27 95.9 0.0 3.5e-27 95.7 0.0 1.0 1 0 0 1 1 1 1 CNH domain Septin PF00735.18 EDN02853.1 - 4.1e-108 360.9 0.1 7.6e-108 360.1 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDN02853.1 - 3.1e-05 24.0 0.0 7.2e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDN02853.1 - 0.0024 17.9 5.1 0.46 10.5 0.0 3.0 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EDN02853.1 - 0.0027 17.3 0.2 0.2 11.2 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDN02853.1 - 0.0065 16.4 3.9 0.011 15.7 0.3 2.9 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 EDN02853.1 - 0.11 11.8 0.0 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 AIG1 family AAA_22 PF13401.6 EDN02853.1 - 0.13 12.5 1.4 0.16 12.2 0.1 2.0 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDN02853.1 - 0.27 11.7 1.4 1.4 9.4 0.0 2.5 2 1 0 2 2 2 0 ABC transporter WD40 PF00400.32 EDN02854.1 - 8e-05 23.3 0.2 1.6 9.7 0.0 3.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN02854.1 - 0.032 14.5 0.0 3.5 8.0 0.0 3.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Clathrin_propel PF01394.20 EDN02854.1 - 0.17 12.3 0.0 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Clathrin propeller repeat RRM_1 PF00076.22 EDN02855.1 - 4.5e-20 71.2 0.4 1.5e-18 66.4 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN02855.1 - 0.00067 19.7 0.0 0.0018 18.3 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif DUF3006 PF11213.8 EDN02855.1 - 0.056 13.7 0.5 2 8.7 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3006) DLIC PF05783.11 EDN02856.1 - 8.7e-38 130.3 0.2 1.7e-34 119.5 0.0 3.0 2 1 1 3 3 3 3 Dynein light intermediate chain (DLIC) Urb2 PF10441.9 EDN02856.1 - 0.053 13.5 0.0 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 Urb2/Npa2 family Peptidase_S9 PF00326.21 EDN02857.1 - 3e-53 180.4 0.0 4.6e-53 179.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EDN02857.1 - 2.8e-06 27.1 0.7 0.11 12.4 0.0 3.9 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 EDN02857.1 - 0.062 12.1 0.0 0.29 9.8 0.0 2.0 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Caps_synth_GfcC PF06251.11 EDN02857.1 - 0.16 11.5 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Y_phosphatase3 PF13350.6 EDN02858.1 - 7.3e-41 140.6 0.0 8.2e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDN02858.1 - 0.0026 17.4 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EDN02858.1 - 0.03 13.9 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EDN02858.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Spermine_synth PF01564.17 EDN02859.1 - 0.0001 21.8 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain DUF2052 PF09747.9 EDN02860.1 - 3.9e-24 85.9 19.1 2.7e-12 47.3 2.1 2.2 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Pkinase PF00069.25 EDN02861.1 - 6.9e-47 160.0 0.0 1.2e-46 159.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02861.1 - 1.5e-25 90.0 0.0 2.6e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN02861.1 - 0.0035 16.7 0.0 0.0069 15.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDN02861.1 - 0.024 13.4 0.6 0.11 11.3 0.1 1.7 1 1 1 2 2 2 0 Fungal protein kinase YjcQ PF09639.10 EDN02861.1 - 0.077 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 YjcQ protein Kdo PF06293.14 EDN02861.1 - 0.13 11.6 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AMP-binding PF00501.28 EDN02863.1 - 8.9e-40 136.6 0.3 1.1e-39 136.2 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN02863.1 - 2.8e-13 50.6 1.8 4.7e-13 49.9 0.6 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Homez PF11569.8 EDN02863.1 - 0.16 11.4 0.1 0.3 10.6 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez UBA_4 PF14555.6 EDN02864.1 - 2.2e-13 49.8 0.9 6e-13 48.4 0.9 1.8 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.16 EDN02864.1 - 0.053 13.2 0.0 2.3 8.0 0.0 2.9 2 0 0 2 2 2 0 CUE domain G-gamma PF00631.22 EDN02864.1 - 5.2 7.2 5.0 55 3.9 1.1 3.0 2 0 0 2 2 2 0 GGL domain Rho_Binding PF08912.11 EDN02864.1 - 7.9 7.4 8.6 22 6.0 2.6 2.7 2 0 0 2 2 2 0 Rho Binding Dynactin_p22 PF07426.11 EDN02865.1 - 0.0023 17.8 0.0 0.2 11.5 0.0 2.2 2 0 0 2 2 2 2 Dynactin subunit p22 SH3_1 PF00018.28 EDN02866.1 - 8.3e-09 34.9 0.1 1.6e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN02866.1 - 4.1e-06 26.5 0.0 8.7e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDN02866.1 - 6.1e-05 22.6 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF4191 PF13829.6 EDN02866.1 - 0.0078 15.6 1.1 0.011 15.1 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4191) DUF2569 PF10754.9 EDN02866.1 - 0.027 14.9 2.5 0.027 14.9 2.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) DUF1129 PF06570.11 EDN02866.1 - 0.21 11.0 3.0 0.31 10.5 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF3446 PF11928.8 EDN02867.1 - 0.0047 17.2 8.5 1 9.7 0.0 2.3 2 0 0 2 2 2 2 Early growth response N-terminal domain DUF515 PF04415.12 EDN02867.1 - 0.37 9.1 3.6 0.47 8.8 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Bot1p PF12298.8 EDN02869.1 - 2.7e-58 196.9 1.4 2.7e-58 196.9 1.4 1.7 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein RRM_1 PF00076.22 EDN02870.1 - 1.1e-14 53.9 0.0 3.9e-14 52.2 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN02870.1 - 0.0078 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Ribosomal_S16 PF00886.19 EDN02872.1 - 1.3e-24 86.0 0.0 1.9e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 YjeF_N PF03853.15 EDN02873.1 - 2.9e-31 108.6 0.0 3.9e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF1769 PF08588.10 EDN02873.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) PALP PF00291.25 EDN02873.1 - 0.15 11.4 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme PUL PF08324.11 EDN02874.1 - 6.2e-73 245.4 1.3 8.6e-73 245.0 1.3 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 EDN02874.1 - 1.5e-43 147.6 0.1 2.9e-43 146.7 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EDN02874.1 - 1.1e-33 114.7 13.4 3.2e-06 27.8 1.2 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 EDN02874.1 - 0.0066 16.5 0.0 0.33 11.0 0.0 2.9 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 EDN02875.1 - 7.1e-14 52.0 7.7 0.013 16.3 0.3 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN02875.1 - 4.6e-05 23.6 0.1 0.15 12.3 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN02875.1 - 0.00029 19.6 0.0 0.18 10.4 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Me-amine-dh_H PF06433.11 EDN02875.1 - 0.0015 17.5 0.0 0.098 11.5 0.0 2.2 2 0 0 2 2 2 2 Methylamine dehydrogenase heavy chain (MADH) RRM_1 PF00076.22 EDN02876.1 - 1.2e-17 63.5 0.0 2.2e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EDN02876.1 - 1.7e-06 28.5 14.7 1.7e-06 28.5 14.7 3.7 3 1 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 CH PF00307.31 EDN02877.1 - 4.7e-41 139.4 0.0 5e-23 81.4 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EDN02877.1 - 4.4e-14 52.3 0.1 1.3e-13 50.9 0.1 1.8 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EDN02877.1 - 5.5e-12 45.4 0.3 4.9e-08 32.7 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EDN02877.1 - 0.00059 19.6 0.1 0.0046 16.8 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain Spectrin PF00435.21 EDN02877.1 - 0.00063 20.2 4.8 0.68 10.4 3.6 2.5 2 0 0 2 2 2 2 Spectrin repeat EF-hand_8 PF13833.6 EDN02877.1 - 0.00099 18.9 0.2 0.0047 16.7 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EDN02877.1 - 0.0053 16.2 0.0 0.073 12.7 0.0 2.6 2 0 0 2 2 2 1 EF hand FliG_N PF14842.6 EDN02877.1 - 0.027 15.0 1.7 3.5 8.2 0.0 3.1 2 1 1 3 3 3 0 FliG N-terminal domain Sigma70_ECF PF07638.11 EDN02877.1 - 0.042 13.7 0.6 0.14 12.0 0.1 2.2 2 0 0 2 2 2 0 ECF sigma factor EIAV_Rev PF11129.8 EDN02877.1 - 0.076 13.2 2.0 0.19 11.9 2.0 1.6 1 0 0 1 1 1 0 Rev protein of equine infectious anaemia virus Fib_alpha PF08702.10 EDN02877.1 - 0.098 12.8 0.0 2.6 8.2 0.0 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family PIN_8 PF18476.1 EDN02877.1 - 0.1 12.4 1.9 0.28 11.0 0.2 2.2 1 1 1 2 2 2 0 PIN like domain Phage_CI_repr PF07022.13 EDN02877.1 - 0.16 12.0 0.0 19 5.4 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain G-alpha PF00503.20 EDN02878.1 - 3.6e-120 401.4 1.8 4.1e-120 401.2 1.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EDN02878.1 - 9.7e-16 57.7 1.3 1.2e-10 41.2 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDN02878.1 - 0.00023 20.6 2.7 0.014 14.8 0.0 2.5 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region zf-CHC2 PF01807.20 EDN02878.1 - 0.00035 20.3 0.0 0.0015 18.3 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger Roc PF08477.13 EDN02878.1 - 0.006 16.8 1.1 2 8.7 0.0 3.3 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDN02878.1 - 0.011 15.8 0.0 6.6 6.8 0.0 3.1 1 1 1 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EDN02878.1 - 0.026 14.3 0.1 0.081 12.7 0.1 1.7 1 1 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 EDN02878.1 - 0.081 12.5 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MCM PF00493.23 EDN02878.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain DDE_1 PF03184.19 EDN02880.1 - 1e-21 77.4 0.0 2e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN02880.1 - 0.00011 22.0 0.9 0.00085 19.1 0.0 2.6 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN02880.1 - 0.062 13.3 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DDRGK PF09756.9 EDN02880.1 - 1.4 8.5 11.4 3.2 7.3 11.4 1.5 1 0 0 1 1 1 0 DDRGK domain FAM176 PF14851.6 EDN02881.1 - 0.32 10.7 3.7 0.78 9.4 3.7 1.6 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 EDN02881.1 - 0.4 8.7 2.1 0.58 8.2 2.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TRAP_alpha PF03896.16 EDN02881.1 - 0.41 9.8 2.3 0.93 8.6 2.3 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 EDN02881.1 - 2.7 7.2 10.2 5.1 6.3 10.2 1.4 1 0 0 1 1 1 0 NOA36 protein RPN2_C PF18004.1 EDN02881.1 - 4.7 7.1 9.5 0.99 9.3 5.1 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nup188_C PF18378.1 EDN02883.1 - 9.1e-143 475.5 0.0 1.4e-142 475.0 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 EDN02883.1 - 6.7e-70 236.1 0.0 2.4e-69 234.3 0.0 1.9 1 1 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 IGPS PF00218.21 EDN02884.1 - 1.1e-93 313.0 0.0 2.4e-93 312.0 0.0 1.5 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EDN02884.1 - 1.4e-50 171.8 0.1 7.3e-48 162.9 0.1 2.3 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EDN02884.1 - 9.9e-14 51.5 0.0 2e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I QRPTase_C PF01729.19 EDN02884.1 - 0.0044 16.8 0.1 0.016 15.0 0.0 2.0 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain NanE PF04131.14 EDN02884.1 - 0.014 14.6 0.1 0.46 9.6 0.0 2.5 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 EDN02884.1 - 0.028 13.9 0.2 0.22 11.0 0.0 2.3 2 0 0 2 2 2 0 Histidine biosynthesis protein FMN_dh PF01070.18 EDN02884.1 - 0.029 13.4 0.1 0.25 10.3 0.0 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Brix PF04427.18 EDN02886.1 - 1.4e-30 106.9 0.1 1.8e-30 106.5 0.1 1.2 1 0 0 1 1 1 1 Brix domain UPF1_Zn_bind PF09416.10 EDN02887.1 - 2.3e-72 242.0 1.3 4e-72 241.2 1.3 1.4 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EDN02887.1 - 5.9e-59 199.1 0.0 8.8e-59 198.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDN02887.1 - 1.5e-53 182.3 3.9 2.2e-30 106.3 0.5 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EDN02887.1 - 2.4e-33 114.2 0.0 5.2e-33 113.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EDN02887.1 - 1.3e-13 51.2 0.4 3.1e-12 46.6 0.4 2.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN02887.1 - 1.6e-10 41.4 0.0 1.1e-09 38.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EDN02887.1 - 3.6e-07 30.4 0.0 6.6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EDN02887.1 - 3.3e-05 23.7 0.1 0.28 10.9 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EDN02887.1 - 0.00019 20.8 0.3 0.0054 16.0 0.0 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EDN02887.1 - 0.00064 19.3 0.0 0.0078 15.8 0.0 2.3 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 EDN02887.1 - 0.00077 19.4 0.4 0.0031 17.4 0.0 2.1 2 0 0 2 2 2 1 Helicase PIF1 PF05970.14 EDN02887.1 - 0.0028 16.9 0.1 0.56 9.3 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase DEAD PF00270.29 EDN02887.1 - 0.0048 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ATPase PF06745.13 EDN02887.1 - 0.02 14.3 0.0 0.06 12.7 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_10 PF12846.7 EDN02887.1 - 0.064 12.2 0.0 0.095 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.6 EDN02887.1 - 0.075 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ribosomal_S13_N PF08069.12 EDN02887.1 - 0.1 12.6 0.0 0.31 11.1 0.0 1.8 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain PhoH PF02562.16 EDN02887.1 - 0.11 12.0 0.1 0.29 10.6 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA PF00004.29 EDN02887.1 - 0.16 12.4 0.3 0.52 10.7 0.3 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EDN02887.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein zf-UBP PF02148.19 EDN02887.1 - 2.2 8.7 6.5 5.5 7.4 6.5 1.7 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein AhpC-TSA_2 PF13911.6 EDN02888.1 - 0.063 13.4 0.0 0.07 13.3 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme VacA2 PF03077.14 EDN02888.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative vacuolating cytotoxin RNase_H PF00075.24 EDN02889.1 - 1.2e-07 32.0 0.1 2.1e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 RNase H RNase_H PF00075.24 EDN02891.1 - 2.7e-06 27.6 0.0 4.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 RNase H Pkinase_fungal PF17667.1 EDN02894.1 - 2.3e-144 481.1 0.0 2.9e-144 480.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN02894.1 - 2.5e-07 30.3 0.0 4.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02894.1 - 0.066 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN02894.1 - 0.077 12.9 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Helo_like_N PF17111.5 EDN02895.1 - 6.7e-57 192.2 0.1 7.8e-57 192.0 0.1 1.0 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EDN02895.1 - 0.13 12.4 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PI-PLC-Y PF00387.19 EDN02896.1 - 2e-09 37.8 0.1 3.3e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EDN02896.1 - 4.9e-07 30.0 0.0 3.7e-06 27.2 0.0 2.0 1 1 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 EDN02897.1 - 0.00032 21.1 0.0 0.00096 19.6 0.0 1.8 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like PH_12 PF16457.5 EDN02897.1 - 0.00084 19.9 0.1 0.0021 18.6 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.32 EDN02897.1 - 0.0025 17.2 0.5 0.064 12.8 0.0 2.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EDN02897.1 - 0.0038 17.0 0.1 2.4 8.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain DUF4734 PF15881.5 EDN02897.1 - 0.0059 16.7 0.1 2.3 8.5 0.0 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF4734) EF-hand_7 PF13499.6 EDN02897.1 - 0.02 15.3 0.2 0.1 13.1 0.2 2.0 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.6 EDN02897.1 - 0.025 14.4 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair HNH_2 PF13391.6 EDN02899.1 - 1.4e-14 54.0 0.2 2.5e-14 53.1 0.2 1.5 1 0 0 1 1 1 1 HNH endonuclease FMN_dh PF01070.18 EDN02900.1 - 4.5e-23 81.8 0.4 1.9e-19 69.9 0.1 2.0 2 0 0 2 2 2 2 FMN-dependent dehydrogenase Oxidored_molyb PF00174.19 EDN02901.1 - 5.1e-55 185.7 0.0 7.4e-55 185.2 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EDN02901.1 - 7.8e-10 38.9 0.6 1.2e-09 38.3 0.1 1.6 2 0 0 2 2 2 1 Mo-co oxidoreductase dimerisation domain Sec5 PF15469.6 EDN02902.1 - 9.1e-33 113.7 0.0 1.6e-32 112.9 0.0 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 EDN02902.1 - 1.6e-05 24.9 0.3 4.6e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 Vps51/Vps67 DUF573 PF04504.14 EDN02903.1 - 0.094 13.4 0.3 0.24 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF573 Eaf7 PF07904.13 EDN02903.1 - 7.1 7.1 6.0 3.4 8.1 0.0 2.8 2 1 1 3 3 3 0 Chromatin modification-related protein EAF7 GCP_C_terminal PF04130.13 EDN02904.1 - 4e-75 253.2 0.1 5.3e-75 252.7 0.1 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EDN02904.1 - 8.3e-15 55.2 1.0 7e-14 52.2 0.0 2.5 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal rRNA_processing PF08524.11 EDN02905.1 - 2.8e-05 24.2 10.4 4.8e-05 23.4 10.4 1.4 1 1 0 1 1 1 1 rRNA processing Phlebovirus_NSM PF07246.11 EDN02905.1 - 0.55 9.6 7.3 0.2 11.0 3.4 1.8 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M Chromosome_seg PF13889.6 EDN02906.1 - 1.8e-22 79.2 0.2 3.7e-22 78.2 0.2 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 EDN02906.1 - 2.1e-15 57.0 0.1 7.8e-15 55.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4210) CAP_N PF01213.19 EDN02907.1 - 8.2e-85 285.1 21.5 8e-42 143.8 12.1 3.6 3 1 0 3 3 3 2 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EDN02907.1 - 1.1e-54 184.3 2.4 1.5e-54 183.9 2.4 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EDN02907.1 - 0.56 10.0 4.4 10 5.9 2.3 2.3 1 1 0 2 2 2 0 Tubulin binding cofactor C PfkB PF00294.24 EDN02908.1 - 1.3e-15 57.6 0.0 3e-15 56.3 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Ribonucleas_3_3 PF14622.6 EDN02910.1 - 3e-07 30.6 0.0 0.00097 19.3 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EDN02910.1 - 7.6e-05 23.4 0.0 0.00015 22.4 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EDN02910.1 - 0.00058 20.5 0.0 0.0024 18.5 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease III domain BSP PF04450.12 EDN02911.1 - 1.9e-36 125.8 0.0 5.5e-27 94.9 0.0 2.2 2 0 0 2 2 2 2 Peptidase of plants and bacteria CLASP_N PF12348.8 EDN02912.1 - 2.6e-149 495.0 0.1 2.6e-87 292.2 0.0 2.7 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 EDN02912.1 - 2.8e-08 33.3 0.0 0.02 15.1 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EDN02912.1 - 1.4e-05 25.2 0.0 0.55 10.3 0.0 4.3 3 2 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN02912.1 - 5.7e-05 23.4 0.3 0.93 9.9 0.0 3.7 3 1 0 4 4 4 2 HEAT repeats DUF3361 PF11841.8 EDN02912.1 - 0.028 14.3 0.0 0.07 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) HEAT_EZ PF13513.6 EDN02912.1 - 0.044 14.3 0.0 35 5.0 0.0 3.4 3 0 0 3 3 3 0 HEAT-like repeat RhoGAP PF00620.27 EDN02913.1 - 9.2e-46 155.4 0.0 2.1e-45 154.2 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EDN02913.1 - 1.3e-14 54.1 18.3 6.3e-10 39.1 2.2 2.4 2 0 0 2 2 2 2 LIM domain zf-ribbon_3 PF13248.6 EDN02913.1 - 2.6 7.6 19.3 1.2 8.7 0.0 4.6 5 1 0 5 5 5 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EDN02913.1 - 3.2 7.7 14.5 0.67 9.9 0.4 3.5 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 EDN02913.1 - 6.9 6.9 19.5 1.8 8.7 1.3 4.3 4 0 0 4 4 4 0 Zinc ribbon domain Thiolase_N PF00108.23 EDN02916.1 - 9.5e-68 228.4 0.0 1.3e-67 227.9 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN02916.1 - 1e-41 141.4 0.7 2.1e-41 140.4 0.1 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EDN02916.1 - 0.0034 17.2 0.0 0.56 10.1 0.0 2.4 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 EDN02916.1 - 0.064 13.4 0.0 0.51 10.5 0.0 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal AA_permease PF00324.21 EDN02918.1 - 9.5e-48 163.0 28.3 4.2e-43 147.6 20.4 3.3 2 2 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EDN02918.1 - 2.2e-16 59.7 19.3 7.1e-16 58.1 19.3 1.9 1 1 0 1 1 1 1 Amino acid permease HSP70 PF00012.20 EDN02919.1 - 2.3e-167 557.8 0.9 3.4e-167 557.3 0.0 1.6 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EDN02919.1 - 2.1e-10 40.0 0.0 5.3e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 EDN02919.1 - 0.0053 17.2 1.4 2.5 8.6 0.0 3.4 3 1 0 3 3 3 2 Cell division protein FtsA DNA_pol3_a_NII PF11490.8 EDN02919.1 - 6.9 6.6 8.1 21 5.0 4.0 3.0 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Chitin_synth_2 PF03142.15 EDN02920.1 - 1.8e-17 63.2 1.1 2.5e-17 62.7 1.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EDN02920.1 - 9.4e-05 22.4 9.5 0.0002 21.3 9.5 1.6 1 1 0 1 1 1 1 Glycosyl transferase family group 2 La PF05383.17 EDN02922.1 - 8.4e-20 70.6 0.1 1.4e-19 69.9 0.1 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EDN02922.1 - 1.2e-05 25.0 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DAO PF01266.24 EDN02923.1 - 1.5e-29 103.7 0.0 1.7e-29 103.5 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDN02923.1 - 0.031 13.6 0.2 0.13 11.4 0.0 2.1 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EDN02924.1 - 2e-21 76.3 37.9 2e-21 76.3 37.9 3.0 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN02924.1 - 4.6e-06 25.3 9.3 7.3e-06 24.7 9.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 EDN02925.1 - 4.1e-10 39.6 12.4 5.9e-10 39.1 12.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S3Ae PF01015.18 EDN02925.1 - 0.19 11.3 0.9 0.29 10.7 0.8 1.3 1 1 0 1 1 1 0 Ribosomal S3Ae family DUF1192 PF06698.11 EDN02925.1 - 0.62 10.2 2.7 0.45 10.6 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) bZIP_1 PF00170.21 EDN02925.1 - 1.8 8.7 6.2 4.3 7.5 0.2 2.4 2 0 0 2 2 2 0 bZIP transcription factor Rox3 PF08633.10 EDN02927.1 - 3.1e-41 141.9 0.1 7e-41 140.8 0.0 1.6 2 0 0 2 2 2 1 Rox3 mediator complex subunit HAD_2 PF13419.6 EDN02928.1 - 2.4e-08 34.3 0.0 5.3e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN02928.1 - 5.1e-06 26.9 0.0 6.8e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN02928.1 - 0.0037 17.3 0.0 0.0077 16.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Uteroglobin PF01099.17 EDN02928.1 - 0.1 13.0 0.0 0.31 11.4 0.0 1.8 1 1 1 2 2 2 0 Uteroglobin family Thr_synth_N PF14821.6 EDN02929.1 - 3.6e-29 100.8 0.0 8.2e-29 99.6 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EDN02929.1 - 4.8e-13 49.2 0.0 1.6e-12 47.4 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4202 PF13875.6 EDN02930.1 - 5.2e-66 222.1 1.2 5.7e-66 222.0 1.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) VIT1 PF01988.19 EDN02931.1 - 7.5e-56 189.4 5.0 8.8e-56 189.2 5.0 1.1 1 0 0 1 1 1 1 VIT family VPS9 PF02204.18 EDN02933.1 - 2.2e-27 95.3 0.0 3.8e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.16 EDN02933.1 - 8.7e-10 38.1 0.1 4.1e-08 32.8 0.0 2.4 2 0 0 2 2 2 1 CUE domain DUF2362 PF10154.9 EDN02933.1 - 0.023 13.7 0.6 0.039 12.9 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Asn_synthase PF00733.21 EDN02934.1 - 6.4e-15 55.7 0.1 9.4e-05 22.2 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 EDN02934.1 - 7.3e-06 25.9 0.0 1.9e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EDN02934.1 - 0.073 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Aluminium induced protein zf-RING_2 PF13639.6 EDN02935.1 - 1.6e-11 44.3 10.1 2.4e-11 43.7 10.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDN02935.1 - 9e-10 38.1 0.9 1.5e-09 37.4 0.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDN02935.1 - 3.9e-07 29.8 9.7 6.1e-07 29.2 9.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN02935.1 - 1e-06 28.5 7.4 1.6e-06 27.8 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDN02935.1 - 3.4e-05 23.7 7.1 5.1e-05 23.1 7.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDN02935.1 - 4.7e-05 23.6 14.2 0.00047 20.4 14.2 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDN02935.1 - 0.00034 20.6 3.2 0.00034 20.6 3.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDN02935.1 - 0.0066 16.5 5.0 0.017 15.2 5.0 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EDN02935.1 - 0.12 12.0 6.4 0.2 11.3 6.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EDN02935.1 - 0.3 11.0 7.8 0.62 10.0 7.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EDN02935.1 - 0.5 10.6 5.9 1.4 9.1 5.9 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EDN02935.1 - 0.59 10.0 9.7 1.1 9.1 9.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 EDN02935.1 - 0.77 9.7 8.9 2.8 7.9 8.9 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 RINGv PF12906.7 EDN02935.1 - 0.93 9.7 6.5 1.9 8.7 6.5 1.6 1 1 0 1 1 1 0 RING-variant domain PHD PF00628.29 EDN02935.1 - 2.2 8.3 9.3 3.9 7.5 9.3 1.4 1 0 0 1 1 1 0 PHD-finger DUF3844 PF12955.7 EDN02936.1 - 6.9e-37 125.8 2.9 1.1e-36 125.1 2.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) HflK_N PF12221.8 EDN02937.1 - 0.13 12.3 0.8 0.44 10.6 0.1 2.2 2 0 0 2 2 2 0 Bacterial membrane protein N terminal Thioredoxin_4 PF13462.6 EDN02939.1 - 4.6e-09 36.6 0.0 7.9e-09 35.9 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin Phage_TAC_6 PF09550.10 EDN02939.1 - 0.063 13.7 0.2 0.14 12.6 0.2 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC DSBA PF01323.20 EDN02939.1 - 0.18 11.6 1.5 0.97 9.2 1.5 2.3 1 1 0 1 1 1 0 DSBA-like thioredoxin domain CKS PF01111.19 EDN02940.1 - 5.9e-34 116.2 0.7 5.9e-34 116.2 0.7 1.4 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit Bromodomain PF00439.25 EDN02941.1 - 1.6e-20 73.0 1.5 3.9e-14 52.5 0.1 2.8 3 0 0 3 3 3 2 Bromodomain HSP70 PF00012.20 EDN02942.1 - 2.8e-224 745.8 5.6 3.1e-224 745.6 5.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDN02942.1 - 1.8e-15 56.6 0.0 1.7e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EDN02942.1 - 7.7e-05 22.5 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EDN02942.1 - 0.045 12.7 0.1 0.44 9.5 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Metallophos PF00149.28 EDN02943.1 - 1.5e-05 25.6 0.0 1.9e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Fungal_trans PF04082.18 EDN02945.1 - 2.8e-09 36.4 0.0 4.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Trm112p PF03966.16 EDN02947.1 - 2.7e-16 59.9 0.0 3.4e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.6 EDN02947.1 - 0.059 13.9 0.2 0.1 13.1 0.2 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF1451 PF07295.11 EDN02947.1 - 0.23 11.5 0.7 0.31 11.1 0.4 1.5 1 1 0 1 1 1 0 Zinc-ribbon containing domain FeS_assembly_P PF01883.19 EDN02948.1 - 4.6e-08 33.1 0.0 1.5e-07 31.4 0.0 1.9 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein GTP_EFTU PF00009.27 EDN02949.1 - 4.9e-46 156.7 0.0 7.3e-46 156.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EDN02949.1 - 9.1e-39 132.8 7.9 1.5e-38 132.1 7.9 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_C PF00679.24 EDN02949.1 - 5.5e-20 71.2 0.0 1.4e-19 69.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDN02949.1 - 1.8e-08 34.6 0.0 4.1e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDN02949.1 - 2.1e-07 31.0 0.2 2.8e-06 27.3 0.0 2.3 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EDN02949.1 - 0.00026 21.1 0.1 0.00054 20.0 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EDN02949.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Septin Thiolase_C PF02803.18 EDN02950.1 - 2.6e-36 124.0 3.5 3e-36 123.8 3.5 1.0 1 0 0 1 1 1 1 Thiolase, C-terminal domain Fungal_trans_2 PF11951.8 EDN02951.1 - 5.4e-09 35.3 0.2 9e-09 34.6 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zip PF02535.22 EDN02952.1 - 1.8e-31 109.6 6.4 1.3e-30 106.8 6.4 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter DUF2401 PF10287.9 EDN02953.1 - 2.6e-90 302.0 0.0 3.1e-90 301.8 0.0 1.1 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) Atg14 PF10186.9 EDN02954.1 - 1.4e-85 287.2 0.3 1.9e-85 286.7 0.3 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 EDN02954.1 - 0.026 13.4 1.6 0.038 12.9 1.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FAM76 PF16046.5 EDN02954.1 - 0.048 13.0 1.9 0.093 12.1 1.9 1.4 1 0 0 1 1 1 0 FAM76 protein TPR_MLP1_2 PF07926.12 EDN02954.1 - 0.064 13.3 2.2 0.13 12.3 2.2 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 EDN02954.1 - 0.12 12.6 0.7 0.22 11.7 0.7 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlgN PF05130.12 EDN02954.1 - 0.12 12.8 1.8 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 FlgN protein Baculo_p24 PF05073.12 EDN02954.1 - 0.14 12.0 1.1 0.28 11.0 1.1 1.5 1 0 0 1 1 1 0 Baculovirus P24 capsid protein CEBP_ZZ PF16366.5 EDN02956.1 - 0.14 12.4 5.9 0.35 11.1 5.9 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain LMBR1 PF04791.16 EDN02957.1 - 4.7e-20 72.0 22.3 2e-19 69.9 5.1 2.3 1 1 1 2 2 2 2 LMBR1-like membrane protein CPSF_A PF03178.15 EDN02958.1 - 7.4e-110 367.2 0.0 3e-109 365.3 0.0 1.9 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 EDN02958.1 - 1.2e-12 47.3 0.0 6.9e-06 25.0 0.0 2.7 1 1 1 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term FAM176 PF14851.6 EDN02958.1 - 0.68 9.6 3.9 3.3 7.4 0.3 2.2 2 0 0 2 2 2 0 FAM176 family AAA PF00004.29 EDN02960.1 - 4.4e-49 166.3 0.0 7.4e-42 142.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN02960.1 - 5.4e-10 38.9 0.0 2e-09 37.1 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDN02960.1 - 2.9e-07 31.0 0.1 4.3e-05 24.0 0.0 3.7 3 0 0 3 3 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EDN02960.1 - 5.1e-07 29.6 0.0 5e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 EDN02960.1 - 1.2e-05 25.5 0.0 3.6e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Bromodomain PF00439.25 EDN02960.1 - 1.9e-05 24.6 0.0 4.8e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Bromodomain AAA_5 PF07728.14 EDN02960.1 - 9.4e-05 22.4 0.0 0.0013 18.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 EDN02960.1 - 0.00015 21.9 0.0 0.58 10.3 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EDN02960.1 - 0.0015 18.8 0.9 0.058 13.7 0.2 3.5 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDN02960.1 - 0.0015 18.9 0.0 0.0045 17.4 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 EDN02960.1 - 0.0063 16.1 0.0 0.026 14.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDN02960.1 - 0.012 15.8 0.5 0.051 13.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDN02960.1 - 0.012 16.1 0.6 0.062 13.8 0.0 2.6 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 EDN02960.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDN02960.1 - 0.016 15.3 0.0 0.097 12.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 EDN02960.1 - 0.017 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EDN02960.1 - 0.02 14.3 0.1 0.093 12.1 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EDN02960.1 - 0.037 13.8 0.0 0.13 12.0 0.0 1.9 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EDN02960.1 - 0.069 12.8 0.0 2.3 7.9 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.12 EDN02960.1 - 0.07 13.0 0.0 0.19 11.6 0.0 1.8 2 0 0 2 2 1 0 NACHT domain ABC_tran PF00005.27 EDN02960.1 - 0.092 13.3 0.0 0.55 10.7 0.0 2.4 1 0 0 1 1 1 0 ABC transporter AAA_3 PF07726.11 EDN02960.1 - 0.11 12.3 0.0 0.36 10.7 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 EDN02960.1 - 0.17 10.9 0.0 0.49 9.4 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EDN02960.1 - 0.18 11.3 0.0 0.41 10.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EDN02960.1 - 0.47 10.2 0.0 0.47 10.2 0.0 4.5 4 1 0 4 4 3 0 AAA domain DUF4950 PF16308.5 EDN02960.1 - 3.2 7.7 8.0 3.8 7.5 4.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4950) Sec66 PF09802.9 EDN02961.1 - 2.9e-82 274.6 0.2 3.5e-82 274.4 0.2 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 PPR_2 PF13041.6 EDN02962.1 - 6.6e-09 35.8 0.1 0.19 12.0 0.0 5.4 5 0 0 5 5 5 2 PPR repeat family PPR_3 PF13812.6 EDN02962.1 - 8.8e-05 22.5 0.1 0.058 13.5 0.0 3.7 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.20 EDN02962.1 - 0.0012 18.9 1.8 0.084 13.2 0.0 4.0 4 0 0 4 4 4 1 PPR repeat PPR_1 PF12854.7 EDN02962.1 - 0.12 12.1 0.9 2.2 8.1 0.2 3.0 3 0 0 3 3 3 0 PPR repeat AAA_32 PF13654.6 EDN02962.1 - 0.28 9.9 9.1 0.43 9.3 9.1 1.2 1 0 0 1 1 1 0 AAA domain ORC3_N PF07034.11 EDN02963.1 - 1.5e-31 109.8 0.0 1.8e-17 63.4 0.0 2.0 2 0 0 2 2 2 2 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EDN02964.1 - 4.3e-28 98.1 0.4 1.1e-14 54.7 0.0 2.0 1 1 1 2 2 2 2 Origin recognition complex winged helix C-terminal Ku PF02735.16 EDN02964.1 - 0.035 13.8 0.0 0.064 13.0 0.0 1.5 1 1 1 2 2 2 0 Ku70/Ku80 beta-barrel domain Nop14 PF04147.12 EDN02965.1 - 8.1e-291 967.3 29.0 9.8e-291 967.0 29.0 1.1 1 0 0 1 1 1 1 Nop14-like family Noc2 PF03715.13 EDN02965.1 - 0.038 13.2 0.0 0.084 12.1 0.0 1.5 1 0 0 1 1 1 0 Noc2p family CitMHS PF03600.16 EDN02965.1 - 0.23 10.6 0.0 0.31 10.2 0.0 1.1 1 0 0 1 1 1 0 Citrate transporter COesterase PF00135.28 EDN02966.1 - 9.4e-83 278.8 0.1 1.1e-82 278.6 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EDN02966.1 - 4.1e-07 30.1 0.0 1.1e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDN02966.1 - 0.00069 19.1 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Cupin_8 PF13621.6 EDN02968.1 - 3.3e-42 145.0 0.0 5.2e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.14 EDN02968.1 - 5.9e-18 65.5 0.0 1e-17 64.7 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Cupin_4 PF08007.12 EDN02968.1 - 1.4e-05 24.7 0.0 2.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein Kelch_5 PF13854.6 EDN02968.1 - 0.0038 17.2 8.3 0.79 9.8 1.6 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EDN02968.1 - 0.021 14.8 19.3 0.33 11.0 0.1 4.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_6 PF13964.6 EDN02968.1 - 0.65 10.4 2.7 3.9 7.9 0.1 2.8 2 0 0 2 2 2 0 Kelch motif ANAPC4_WD40 PF12894.7 EDN02969.1 - 0.00033 20.9 0.0 0.47 10.8 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN02969.1 - 0.00047 20.9 0.8 0.056 14.3 0.0 4.3 5 1 0 5 5 5 1 WD domain, G-beta repeat CNH PF00780.22 EDN02969.1 - 0.0074 15.9 0.1 2.7 7.5 0.0 2.3 2 0 0 2 2 2 2 CNH domain Hira PF07569.11 EDN02969.1 - 0.037 13.8 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split PNP_UDP_1 PF01048.20 EDN02970.1 - 0.0032 16.8 0.1 0.013 14.8 0.1 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily Fungal_trans_2 PF11951.8 EDN02972.1 - 0.0026 16.6 0.6 0.0043 15.9 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN02972.1 - 0.04 14.0 5.2 0.079 13.1 5.2 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EDN02973.1 - 2.6e-23 82.5 38.9 4.3e-23 81.8 38.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Met_10 PF02475.16 EDN02974.1 - 0.00092 19.0 0.0 0.002 17.9 0.0 1.5 2 0 0 2 2 2 1 Met-10+ like-protein EF-hand_6 PF13405.6 EDN02975.1 - 2.2e-09 36.5 0.1 0.0034 17.2 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EDN02975.1 - 2.1e-05 24.9 1.0 0.013 15.9 0.0 2.9 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EDN02975.1 - 2.9e-05 23.3 0.0 0.00051 19.4 0.0 2.3 2 0 0 2 2 2 1 EF hand Skp1 PF01466.19 EDN02975.1 - 0.14 12.3 1.1 6.9 6.9 0.1 2.4 2 0 0 2 2 2 0 Skp1 family, dimerisation domain MSP1_C PF07462.11 EDN02976.1 - 0.03 13.0 0.9 0.055 12.2 0.9 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF4140 PF13600.6 EDN02976.1 - 3.7 8.1 5.4 5.6 7.5 0.5 3.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Rho_Binding PF08912.11 EDN02976.1 - 3.8 8.4 7.2 4.5 8.1 0.5 2.9 2 0 0 2 2 2 0 Rho Binding OB_NTP_bind PF07717.16 EDN02977.1 - 6.4e-21 74.5 0.0 2e-20 72.9 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDN02977.1 - 1.2e-18 67.4 0.0 3.1e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDN02977.1 - 6e-11 42.7 0.0 1.9e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN02977.1 - 1.5e-07 31.4 0.3 2.9e-07 30.4 0.3 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDN02977.1 - 1.6e-05 25.2 0.6 5.3e-05 23.5 0.1 2.1 3 0 0 3 3 3 1 AAA domain SRP54 PF00448.22 EDN02977.1 - 0.00067 19.3 0.3 0.0022 17.7 0.3 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.14 EDN02977.1 - 0.0011 19.0 0.1 0.002 18.1 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 EDN02977.1 - 0.0031 17.9 0.2 0.0063 16.9 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN02977.1 - 0.0033 17.2 0.1 0.006 16.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain YfhO PF09586.10 EDN02977.1 - 0.087 11.0 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO AAA_7 PF12775.7 EDN02977.1 - 0.11 12.0 0.0 0.35 10.3 0.0 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EDN02977.1 - 0.13 12.8 0.1 0.3 11.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter PRMT5_TIM PF17285.2 EDN02978.1 - 2.7e-52 177.5 0.0 3.5e-51 173.9 0.0 2.0 1 1 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 EDN02978.1 - 1e-46 159.1 0.0 1.9e-46 158.2 0.0 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 EDN02978.1 - 1.2e-46 158.8 0.0 2.1e-46 157.9 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase GDPD PF03009.17 EDN02979.1 - 1.7e-44 152.5 0.0 1.9e-44 152.4 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SPX PF03105.19 EDN02980.1 - 1.2e-20 74.8 0.6 1.4e-11 45.0 0.0 3.0 1 1 2 3 3 3 2 SPX domain Ank_2 PF12796.7 EDN02980.1 - 1.2e-18 67.5 0.6 2.3e-08 34.5 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN02980.1 - 3.8e-15 56.0 1.4 2.7e-07 31.0 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN02980.1 - 1.3e-13 50.9 0.8 2e-05 24.8 0.1 4.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN02980.1 - 2e-13 49.2 1.2 0.0047 17.3 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EDN02980.1 - 1.2e-11 44.5 4.4 0.0082 16.6 0.1 4.9 3 1 0 3 3 3 3 Ankyrin repeat UNC45-central PF11701.8 EDN02981.1 - 1.2e-46 158.4 1.9 1.9e-46 157.8 0.4 2.1 2 1 0 2 2 2 1 Myosin-binding striated muscle assembly central RICTOR_N PF14664.6 EDN02981.1 - 0.00089 18.3 0.2 0.0019 17.3 0.2 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term Arm PF00514.23 EDN02981.1 - 0.0082 16.2 7.7 3.1 8.0 0.0 5.2 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat Tfb4 PF03850.14 EDN02982.1 - 1.1e-111 372.7 0.0 1.4e-111 372.5 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 Asparaginase_2 PF01112.18 EDN02983.1 - 1.6e-46 158.8 3.6 3.5e-31 108.4 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Actin PF00022.19 EDN02984.1 - 2.6e-87 293.1 0.0 2.3e-85 286.6 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDN02984.1 - 0.00026 19.9 0.1 0.01 14.6 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDN02984.1 - 0.0018 18.7 0.0 0.0029 18.0 0.0 1.4 1 0 0 1 1 1 1 Cell division protein FtsA tRNA_U5-meth_tr PF05958.11 EDN02985.1 - 1.8e-06 27.2 0.1 6.4e-05 22.1 0.0 2.7 3 0 0 3 3 3 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EDN02985.1 - 1.4e-05 24.9 0.0 2.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN02985.1 - 5.5e-05 23.8 0.0 0.00026 21.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EDN02985.1 - 0.015 14.9 0.0 0.059 12.9 0.0 2.0 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 EDN02985.1 - 0.029 15.0 0.0 0.08 13.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EDN02985.1 - 0.062 14.0 0.0 0.31 11.8 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain RNA_capsid PF03035.14 EDN02985.1 - 0.19 11.7 2.4 1 9.3 0.7 2.1 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein PrmA PF06325.13 EDN02985.1 - 0.61 9.4 1.8 0.49 9.7 0.1 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Ribosomal_S5_C PF03719.15 EDN02986.1 - 1.1e-24 85.7 0.0 2.3e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EDN02986.1 - 6.6e-18 64.5 0.3 6.6e-18 64.5 0.3 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain HhH-GPD PF00730.25 EDN02986.1 - 0.0031 18.0 0.2 2.9 8.4 0.0 2.8 2 1 0 2 2 2 2 HhH-GPD superfamily base excision DNA repair protein DUF3253 PF11625.8 EDN02986.1 - 0.057 13.7 0.3 0.39 11.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3253) AMP_N PF05195.16 EDN02986.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Aminopeptidase P, N-terminal domain RFC1 PF08519.12 EDN02986.1 - 0.41 10.8 2.0 0.75 9.9 0.4 2.3 2 1 1 3 3 3 0 Replication factor RFC1 C terminal domain DASH_Dad3 PF08656.10 EDN02987.1 - 1.6e-17 63.3 0.0 1.6e-17 63.3 0.0 1.6 2 0 0 2 2 2 1 DASH complex subunit Dad3 SUIM_assoc PF16619.5 EDN02987.1 - 0.045 13.8 1.3 0.045 13.8 1.3 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 EDN02988.1 - 4e-45 154.3 0.0 1.9e-22 79.9 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN02988.1 - 1.2e-15 57.6 0.0 1.7e-07 30.8 0.0 2.1 1 1 0 2 2 2 2 Protein tyrosine kinase CytadhesinP1 PF12378.8 EDN02989.1 - 9.4 6.5 7.2 19 5.5 7.2 1.5 1 0 0 1 1 1 0 Trypsin-sensitive surface-exposed protein His_Phos_2 PF00328.22 EDN02991.1 - 1.2e-06 28.2 0.0 1.3e-06 28.1 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) TRF PF08558.10 EDN02992.1 - 5.2e-92 307.8 0.8 7.9e-92 307.2 0.8 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EDN02992.1 - 0.00065 19.8 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain TFIID_30kDa PF03540.13 EDN02993.1 - 5.3e-23 80.7 0.1 8.9e-23 80.0 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_S19 PF00203.21 EDN02994.1 - 1.5e-21 76.0 0.0 2.4e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 IPK PF03770.16 EDN02995.1 - 2.8e-60 203.6 0.0 4.8e-60 202.8 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Arb1 PF09692.10 EDN02996.1 - 2.7e-83 280.4 0.4 4.9e-43 147.8 0.6 2.2 2 0 0 2 2 2 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 ADH_zinc_N_2 PF13602.6 EDN02997.1 - 1.3e-25 90.9 0.0 2.4e-25 90.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDN02997.1 - 1.5e-25 89.7 0.3 2.7e-25 88.8 0.1 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN02997.1 - 2.3e-09 37.1 0.0 4.1e-08 33.1 0.0 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EDN02997.1 - 0.0018 18.2 0.0 0.0046 16.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Sgf11 PF08209.11 EDN02999.1 - 0.034 13.7 0.7 0.034 13.7 0.7 2.1 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) CLP1_N PF16573.5 EDN03000.1 - 2.8e-29 101.2 0.0 5.8e-29 100.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EDN03000.1 - 5.9e-26 91.2 0.0 1e-23 83.9 0.0 2.6 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 EDN03000.1 - 1.9e-18 66.9 0.0 2.2e-13 50.4 0.0 2.8 2 1 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop ATP_bind_1 PF03029.17 EDN03000.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EDN03000.1 - 0.085 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDN03000.1 - 0.14 12.7 0.4 0.32 11.5 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Roughex PF06020.11 EDN03000.1 - 0.22 10.6 2.6 0.4 9.7 2.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein AAA_35 PF14516.6 EDN03000.1 - 0.25 10.1 0.0 0.39 9.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain Herpes_DNAp_acc PF04929.12 EDN03001.1 - 2 7.3 7.3 2.6 7.0 7.3 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CDC45 PF02724.14 EDN03001.1 - 5.8 5.1 6.6 6.9 4.8 6.6 1.0 1 0 0 1 1 1 0 CDC45-like protein KilA-N PF04383.13 EDN03002.1 - 0.0011 18.8 0.0 0.037 13.9 0.0 2.4 1 1 0 1 1 1 1 KilA-N domain Metallophos PF00149.28 EDN03003.1 - 5.3e-37 128.3 0.4 7.4e-37 127.8 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDN03003.1 - 0.0023 18.3 0.6 0.0066 16.9 0.6 1.8 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Wound_ind PF08186.11 EDN03004.1 - 0.61 10.6 4.6 5.5 7.5 1.6 2.6 2 0 0 2 2 2 0 Wound-inducible basic protein family BNIP3 PF06553.12 EDN03004.1 - 2.5 7.7 7.3 1.4 8.5 5.6 1.5 1 1 0 1 1 1 0 BNIP3 Adaptin_N PF01602.20 EDN03005.1 - 3.1e-71 240.5 0.0 3.9e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDN03005.1 - 2.2e-10 40.8 0.1 7.2e-08 32.6 0.0 3.2 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN03005.1 - 1.5e-06 28.5 0.8 0.075 13.4 0.1 3.8 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EDN03005.1 - 0.002 18.2 0.4 0.64 10.4 0.0 4.5 5 0 0 5 5 5 1 HEAT repeat Mpp10 PF04006.12 EDN03005.1 - 0.035 12.5 18.4 0.055 11.9 18.4 1.2 1 0 0 1 1 1 0 Mpp10 protein RasGEF_N_2 PF14663.6 EDN03005.1 - 0.11 12.9 0.2 0.6 10.5 0.1 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arm PF00514.23 EDN03005.1 - 0.15 12.1 2.0 1.5 8.9 0.3 3.2 4 0 0 4 4 3 0 Armadillo/beta-catenin-like repeat Nop14 PF04147.12 EDN03005.1 - 0.15 10.2 22.8 0.24 9.6 22.8 1.2 1 0 0 1 1 1 0 Nop14-like family HEAT_EZ PF13513.6 EDN03005.1 - 0.2 12.2 0.7 23 5.6 0.0 3.6 3 0 0 3 3 3 0 HEAT-like repeat CDC45 PF02724.14 EDN03005.1 - 0.22 9.7 16.1 0.33 9.2 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 EDN03005.1 - 0.78 8.3 20.3 1.2 7.6 20.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BSP_II PF05432.11 EDN03005.1 - 1.2 8.8 27.4 0.082 12.6 21.3 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) BUD22 PF09073.10 EDN03005.1 - 1.2 8.4 19.2 2.1 7.6 19.2 1.3 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EDN03005.1 - 1.7 8.0 24.5 3.4 7.0 24.5 1.4 1 0 0 1 1 1 0 SDA1 DUF913 PF06025.12 EDN03005.1 - 3.6 6.5 7.7 45 2.8 7.2 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SpoIIIAH PF12685.7 EDN03005.1 - 4.7 7.0 12.1 11 5.7 12.1 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein RNA_pol_Rpc4 PF05132.14 EDN03005.1 - 5.3 7.5 6.3 11 6.4 6.3 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 EDN03005.1 - 5.4 6.8 15.1 9.8 5.9 15.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 EDN03005.1 - 6.1 7.0 7.5 14 5.8 7.5 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4637 PF15470.6 EDN03005.1 - 7.9 6.2 19.5 23 4.7 19.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Tim54 PF11711.8 EDN03005.1 - 9.3 4.9 8.5 15 4.3 8.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DHR10 PF18595.1 EDN03007.1 - 2.1e-33 114.8 18.6 2.1e-33 114.8 18.6 4.1 3 1 0 3 3 3 1 Designed helical repeat protein 10 domain Nuf2 PF03800.14 EDN03007.1 - 2.4e-31 108.7 4.3 5.2e-16 59.0 0.2 3.2 2 2 1 3 3 3 2 Nuf2 family Clr5 PF14420.6 EDN03007.1 - 0.16 12.2 3.3 5.4 7.3 0.2 3.1 3 0 0 3 3 3 0 Clr5 domain UPF0242 PF06785.11 EDN03007.1 - 2.2 8.3 49.5 0.15 12.1 11.1 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus IF-2B PF01008.17 EDN03008.1 - 6.4e-43 147.0 0.0 8.2e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EDN03008.1 - 0.15 12.0 0.0 20 5.1 0.0 2.3 2 0 0 2 2 2 0 DeoR C terminal sensor domain DUF1681 PF07933.14 EDN03010.1 - 7.8e-57 191.1 0.0 1e-56 190.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Thioredoxin PF00085.20 EDN03014.1 - 8.3e-27 93.2 0.2 9.3e-27 93.0 0.2 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDN03014.1 - 1.3e-07 32.1 0.7 1.3e-06 28.8 0.7 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EDN03014.1 - 2.4e-06 27.3 0.0 2.8e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDN03014.1 - 4.1e-06 27.0 0.0 3.3e-05 24.1 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 EDN03014.1 - 0.00013 21.7 0.5 0.0022 17.7 0.4 2.0 1 1 1 2 2 2 1 Redoxin OST3_OST6 PF04756.13 EDN03014.1 - 0.0011 18.3 0.1 0.0015 17.9 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Phosducin PF02114.16 EDN03014.1 - 0.0033 16.4 0.0 0.004 16.1 0.0 1.1 1 0 0 1 1 1 1 Phosducin TraF PF13728.6 EDN03014.1 - 0.0038 17.1 0.0 0.0042 16.9 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 EDN03014.1 - 0.004 17.1 0.2 0.0076 16.2 0.2 1.6 1 1 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 EDN03014.1 - 0.004 17.3 0.2 0.0062 16.7 0.2 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_5 PF13743.6 EDN03014.1 - 0.028 14.1 0.1 0.068 12.9 0.0 1.7 1 1 1 2 2 2 0 Thioredoxin HyaE PF07449.11 EDN03014.1 - 0.061 13.3 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE APOBEC3 PF18771.1 EDN03014.1 - 0.063 13.4 0.1 0.088 12.9 0.1 1.2 1 0 0 1 1 1 0 APOBEC3 Thioredoxin_7 PF13899.6 EDN03014.1 - 0.12 12.6 0.2 0.2 11.9 0.2 1.6 1 1 0 1 1 1 0 Thioredoxin-like PPP4R2 PF09184.11 EDN03015.1 - 8.5 5.9 32.1 0.69 9.5 17.8 2.1 2 0 0 2 2 2 0 PPP4R2 OTU PF02338.19 EDN03016.1 - 0.00016 22.1 0.0 0.00026 21.5 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease DAO PF01266.24 EDN03017.1 - 3.1e-30 106.0 2.1 4e-30 105.6 2.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN03017.1 - 0.0062 15.8 0.1 0.07 12.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN03017.1 - 0.0077 16.4 0.1 0.023 14.9 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDN03017.1 - 0.044 13.0 0.6 0.13 11.5 0.1 2.0 2 0 0 2 2 2 0 Thi4 family MRP-S35 PF10246.9 EDN03017.1 - 0.069 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 Sacchrp_dh_NADP PF03435.18 EDN03017.1 - 0.11 12.7 0.3 0.52 10.6 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_4 PF01565.23 EDN03018.1 - 9.8e-26 90.2 0.5 1.6e-25 89.5 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain COPI_assoc PF08507.10 EDN03019.1 - 3.2e-33 114.5 3.8 3.5e-33 114.4 3.8 1.0 1 0 0 1 1 1 1 COPI associated protein Bax1-I PF01027.20 EDN03019.1 - 0.008 16.0 5.8 0.01 15.7 5.8 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 ARL6IP6 PF15062.6 EDN03019.1 - 0.29 11.3 1.7 7.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix UCR_Fe-S_N PF10399.9 EDN03019.1 - 0.55 9.6 2.2 0.48 9.8 0.3 1.9 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF2371 PF10177.9 EDN03019.1 - 0.61 10.3 3.9 12 6.1 3.9 2.2 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF2583 PF10762.9 EDN03019.1 - 1.6 9.2 5.3 9.7 6.7 0.0 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF2583) GATA PF00320.27 EDN03020.1 - 2.2e-27 94.3 17.8 2.9e-14 52.4 3.9 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDN03020.1 - 2.9e-05 23.5 2.7 0.0064 16.0 0.1 2.6 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EDN03020.1 - 0.0014 18.7 4.0 0.41 10.8 0.5 2.8 2 0 0 2 2 2 2 Zinc ribbon domain ArfGap PF01412.18 EDN03020.1 - 0.003 17.6 2.2 0.31 11.1 0.1 2.5 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf OrfB_Zn_ribbon PF07282.11 EDN03020.1 - 0.02 14.8 1.1 0.02 14.8 1.1 3.0 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Auto_anti-p27 PF06677.12 EDN03020.1 - 0.022 14.9 5.6 0.42 10.8 0.3 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 EDN03020.1 - 0.023 14.7 10.8 12 6.0 10.7 2.9 1 1 0 1 1 1 0 Double zinc ribbon eIF-5_eIF-2B PF01873.17 EDN03020.1 - 0.16 11.9 4.9 4.8 7.1 0.4 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Jiv90 PF14901.6 EDN03020.1 - 0.48 10.6 2.8 3.1 8.0 0.1 2.5 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone adh_short PF00106.25 EDN03022.1 - 2.5e-19 69.5 0.1 1.5e-17 63.7 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03022.1 - 7e-10 38.8 0.1 7.2e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EDN03022.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EDN03025.1 - 3.7e-55 186.4 0.0 4.8e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03025.1 - 3.6e-37 128.2 0.0 4.4e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN03025.1 - 1e-12 48.3 0.0 1.5e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDN03025.1 - 0.0028 16.8 0.1 0.0052 16.0 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EDN03025.1 - 0.016 15.4 0.1 0.028 14.7 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain THF_DHG_CYH_C PF02882.19 EDN03025.1 - 0.11 11.8 1.2 1.1 8.6 0.0 2.7 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Cofilin_ADF PF00241.20 EDN03026.1 - 4.9e-15 55.4 0.0 6.2e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Trypan_PARP PF05887.11 EDN03027.1 - 0.0025 17.8 2.7 0.0025 17.8 2.7 2.1 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) NESP55 PF06390.12 EDN03027.1 - 0.022 14.4 1.5 0.022 14.4 1.5 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) FAM176 PF14851.6 EDN03027.1 - 0.25 11.0 3.0 0.42 10.3 3.0 1.4 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EDN03027.1 - 1.3 8.2 7.3 1.8 7.8 7.3 1.1 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 EDN03027.1 - 2.3 8.0 8.0 3.5 7.4 8.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.11 EDN03027.1 - 9.5 4.9 6.7 13 4.5 6.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 HTH_7 PF02796.15 EDN03028.1 - 1.9e-07 31.0 0.0 5.1e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN03028.1 - 2.7e-06 27.0 0.0 0.00011 21.9 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN03028.1 - 5.8e-06 25.9 0.0 3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_29 PF13551.6 EDN03028.1 - 7.4e-06 25.9 0.0 5.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN03028.1 - 5.5e-05 22.8 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN03028.1 - 0.00018 21.4 0.0 0.00029 20.8 0.0 1.3 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN03028.1 - 0.0071 16.9 0.0 1.2 9.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 EDN03028.1 - 0.036 13.6 0.5 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN03028.1 - 0.047 13.8 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN03028.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN03028.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein MoCF_biosynth PF00994.24 EDN03029.1 - 3e-33 114.5 0.0 5e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Ras PF00071.22 EDN03030.1 - 1.4e-45 154.8 0.2 1.7e-45 154.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN03030.1 - 4.3e-21 75.4 0.0 5.3e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN03030.1 - 2.8e-08 33.4 0.0 3.1e-08 33.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN03030.1 - 3.2e-06 26.8 0.1 2.3e-05 24.0 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDN03030.1 - 0.00058 19.9 0.0 0.00094 19.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDN03030.1 - 0.021 14.7 0.6 0.51 10.2 0.1 2.4 1 1 2 3 3 3 0 RsgA GTPase IstB_IS21 PF01695.17 EDN03030.1 - 0.079 12.7 1.0 1.5 8.5 0.1 2.1 1 1 1 2 2 2 0 IstB-like ATP binding protein CbiA PF01656.23 EDN03030.1 - 0.22 11.6 0.5 0.51 10.4 0.5 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain TRAF6_Z2 PF18048.1 EDN03031.1 - 0.013 15.6 3.3 0.045 13.8 0.2 2.4 2 1 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 FAD_binding_3 PF01494.19 EDN03032.1 - 3.3e-09 36.5 0.4 6.1e-08 32.3 0.4 2.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDN03032.1 - 0.0013 18.4 0.5 0.0017 18.0 0.5 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDN03032.1 - 0.0049 17.1 0.0 0.032 14.4 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDN03032.1 - 0.0061 15.8 0.0 0.034 13.4 0.0 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDN03032.1 - 0.013 14.4 0.4 0.031 13.1 0.0 1.8 2 0 0 2 2 2 0 Tryptophan halogenase Patatin PF01734.22 EDN03032.1 - 0.03 14.5 0.2 0.12 12.5 0.1 2.0 2 0 0 2 2 2 0 Patatin-like phospholipase RLAN PF14401.6 EDN03032.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain MFS_1 PF07690.16 EDN03033.1 - 1.7e-33 116.0 55.7 1.7e-33 116.0 55.7 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN03033.1 - 2e-12 46.4 25.0 4.3e-12 45.2 25.1 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zn_ribbon_17 PF17120.5 EDN03035.1 - 0.017 14.8 4.7 0.017 14.8 4.7 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Siva PF05458.12 EDN03035.1 - 0.13 11.9 13.0 1.6 8.4 3.0 2.5 2 0 0 2 2 2 0 Cd27 binding protein (Siva) FYVE_2 PF02318.16 EDN03035.1 - 0.15 12.3 14.7 1.1 9.5 2.0 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger zf-RING_6 PF14835.6 EDN03035.1 - 0.64 9.9 14.6 1.7 8.6 3.6 2.5 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 EDN03035.1 - 4.7 7.1 22.5 7 6.6 5.9 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Copper-bind PF00127.20 EDN03037.1 - 0.0011 19.4 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family DIOX_N PF14226.6 EDN03038.1 - 1.5e-13 51.6 0.0 2.5e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EDN03038.1 - 1.9e-13 50.8 0.0 6.3e-13 49.1 0.0 1.9 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily UPF0086 PF01868.16 EDN03039.1 - 2.1e-30 104.5 0.1 3e-30 103.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function UPF0086 tRNA_int_endo PF01974.17 EDN03040.1 - 1.5e-15 57.0 0.0 3.5e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PAXNEB PF05625.11 EDN03041.1 - 6e-115 384.3 0.0 7.3e-115 384.0 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein RNA_pol_Rpb8 PF03870.15 EDN03042.1 - 2.5e-34 118.5 0.0 2.9e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 DUF4743 PF15916.5 EDN03043.1 - 1.5e-12 47.6 0.0 2.2e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 EDN03043.1 - 1.1e-10 41.6 0.0 2.2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Tir_receptor_C PF07489.11 EDN03045.1 - 0.11 12.4 11.1 0.18 11.8 11.1 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus AJAP1_PANP_C PF15298.6 EDN03045.1 - 0.15 12.2 14.0 0.23 11.7 14.0 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Dicty_REP PF05086.12 EDN03045.1 - 0.63 8.0 11.0 0.72 7.8 11.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EDN03045.1 - 3 5.9 11.8 3.6 5.6 11.8 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 EDN03045.1 - 4.9 7.1 33.2 6.9 6.7 33.2 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein LRR_9 PF14580.6 EDN03046.1 - 3.5e-60 202.5 0.4 3.5e-60 202.5 0.4 1.5 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 EDN03046.1 - 1.7e-06 27.7 1.9 1.7e-06 27.7 1.9 2.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EDN03046.1 - 1.6e-05 25.1 11.0 0.00033 21.0 0.7 3.6 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) DUF4349 PF14257.6 EDN03046.1 - 0.0089 15.5 1.8 0.014 14.9 1.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) GDA1_CD39 PF01150.17 EDN03047.1 - 1.8e-96 323.4 0.0 2.6e-96 322.9 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Acyltransferase PF01553.21 EDN03048.1 - 3.3e-09 36.5 0.0 8.6e-05 22.2 0.0 2.6 1 1 1 2 2 2 2 Acyltransferase RT_RNaseH PF17917.1 EDN03050.1 - 5.5e-28 97.3 0.2 1.2e-27 96.3 0.2 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN03050.1 - 1.1e-19 70.2 2.8 1.2e-19 70.1 0.3 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 EDN03050.1 - 7.3e-15 54.8 0.0 1.6e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Chromo PF00385.24 EDN03050.1 - 1.1e-14 54.0 3.0 2.9e-14 52.7 3.0 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN03050.1 - 6.1e-13 49.0 0.0 1.8e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN03050.1 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN03050.1 - 0.11 12.6 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 MscS_porin PF12795.7 EDN03051.1 - 8.5e-05 22.2 14.1 0.00013 21.7 14.1 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF3552 PF12072.8 EDN03051.1 - 0.0047 16.4 13.1 0.0047 16.4 13.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) V_ATPase_I PF01496.19 EDN03051.1 - 0.0079 14.2 0.2 0.01 13.8 0.2 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 EDN03051.1 - 0.0096 16.0 1.7 0.019 15.0 1.5 1.7 2 0 0 2 2 1 1 Protein of unknown function (DUF1664) YabA PF06156.13 EDN03051.1 - 0.011 16.3 5.8 0.013 16.2 0.1 2.4 1 1 1 2 2 2 0 Initiation control protein YabA IATP PF04568.12 EDN03051.1 - 0.012 16.0 1.2 0.012 16.0 1.2 2.1 1 1 1 2 2 2 0 Mitochondrial ATPase inhibitor, IATP APG6_N PF17675.1 EDN03051.1 - 0.033 14.7 14.5 0.059 13.9 14.5 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 EDN03051.1 - 0.046 13.3 5.2 0.069 12.7 5.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4200 PF13863.6 EDN03051.1 - 0.065 13.6 12.2 0.14 12.6 12.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 EDN03051.1 - 0.1 11.9 11.5 0.16 11.3 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HMMR_N PF15905.5 EDN03051.1 - 0.12 11.8 8.5 0.18 11.2 8.5 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FAM76 PF16046.5 EDN03051.1 - 0.25 10.6 1.7 0.37 10.1 1.7 1.3 1 0 0 1 1 1 0 FAM76 protein Spc7 PF08317.11 EDN03051.1 - 0.28 10.0 13.8 0.66 8.8 13.8 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Rho_Binding PF08912.11 EDN03051.1 - 0.6 11.0 5.4 3.4 8.5 2.1 2.5 2 0 0 2 2 2 0 Rho Binding ADIP PF11559.8 EDN03051.1 - 0.61 10.2 11.0 1.2 9.2 11.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 EDN03051.1 - 0.92 9.6 10.1 0.48 10.5 1.1 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Cnn_1N PF07989.11 EDN03051.1 - 1.9 8.7 8.3 5.9 7.1 2.0 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Spc24 PF08286.11 EDN03051.1 - 1.9 8.7 13.1 2.1 8.6 0.8 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF1043 PF06295.12 EDN03051.1 - 3.3 7.7 5.7 6.2 6.9 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) OmpH PF03938.14 EDN03051.1 - 4.3 7.7 15.6 29 5.0 15.6 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 EDN03051.1 - 5.1 7.2 13.9 8.8 6.4 4.9 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 EDN03051.1 - 7.3 6.8 17.8 19 5.4 17.9 1.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 MscS_porin PF12795.7 EDN03052.1 - 0.0039 16.8 17.5 0.0073 15.9 17.5 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF3552 PF12072.8 EDN03052.1 - 0.0061 16.0 12.7 0.0061 16.0 12.7 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) DUF1664 PF07889.12 EDN03052.1 - 0.016 15.2 1.2 0.028 14.5 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 EDN03052.1 - 0.016 13.2 0.2 0.022 12.7 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EDN03052.1 - 0.022 15.4 0.1 0.022 15.4 0.1 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Spc7 PF08317.11 EDN03052.1 - 0.037 12.9 9.9 0.068 12.0 9.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 EDN03052.1 - 0.077 13.5 15.5 0.22 12.0 15.5 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region eIF3g PF12353.8 EDN03052.1 - 0.11 12.8 0.2 0.29 11.5 0.2 1.7 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G HMMR_N PF15905.5 EDN03052.1 - 0.32 10.4 9.0 0.51 9.8 9.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Jnk-SapK_ap_N PF09744.9 EDN03052.1 - 0.93 9.7 13.5 2 8.6 13.5 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1043 PF06295.12 EDN03052.1 - 5.6 7.0 5.7 11 6.0 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Exonuc_VII_L PF02601.15 EDN03052.1 - 7.8 6.0 11.6 1 8.9 7.3 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit Integrase_H2C2 PF17921.1 EDN03053.1 - 9.6e-14 51.2 0.0 1.9e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN03053.1 - 9.6e-14 51.6 0.0 2e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN03053.1 - 9.3e-07 28.7 0.1 2.5e-06 27.3 0.1 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 EDN03053.1 - 4e-06 26.5 0.0 7e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo_shadow PF01393.19 EDN03053.1 - 0.0042 17.2 0.1 0.0081 16.2 0.1 1.5 1 0 0 1 1 1 1 Chromo shadow domain zf-H2C2 PF09337.10 EDN03053.1 - 0.026 14.7 0.0 0.059 13.6 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger gag_pre-integrs PF13976.6 EDN03053.1 - 0.05 13.5 0.1 0.098 12.5 0.1 1.5 1 0 0 1 1 1 0 GAG-pre-integrase domain DUF3293 PF11697.8 EDN03053.1 - 0.15 12.5 0.1 0.71 10.4 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) Pkinase_fungal PF17667.1 EDN03054.1 - 4e-126 421.1 0.0 4.9e-126 420.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase SurA_N_3 PF13624.6 EDN03054.1 - 0.011 15.5 0.1 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 SurA N-terminal domain DCD PF06559.11 EDN03054.1 - 0.055 12.3 0.0 0.085 11.6 0.0 1.2 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) DUF3435 PF11917.8 EDN03055.1 - 4.8e-103 345.3 7.8 9.3e-92 308.1 1.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) SLD5_C PF16922.5 EDN03056.1 - 0.16 12.2 0.1 0.24 11.6 0.1 1.4 1 1 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus Pantoate_ligase PF02569.15 EDN03057.1 - 2.4e-93 312.2 0.0 2.8e-93 312.0 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Glyco_hydro_100 PF12899.7 EDN03057.1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase DEAD PF00270.29 EDN03058.1 - 8.8e-44 149.4 0.1 1.4e-43 148.7 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN03058.1 - 1e-20 74.1 0.0 8.8e-20 71.1 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDN03058.1 - 2.9e-19 69.1 0.0 6.2e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDN03058.1 - 1.6e-06 28.2 0.0 3.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDN03058.1 - 0.042 13.0 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase WD40 PF00400.32 EDN03059.1 - 3.4e-05 24.5 0.1 0.00077 20.2 0.1 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat Pyridox_oxase_2 PF12766.7 EDN03060.1 - 3.8e-06 27.4 0.0 6.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase adh_short PF00106.25 EDN03064.1 - 1.1e-23 83.8 0.0 6.7e-23 81.2 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03064.1 - 4.1e-16 59.3 0.0 1.1e-15 57.8 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN03064.1 - 0.00087 19.2 0.1 0.0016 18.4 0.1 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDN03064.1 - 0.01 15.8 0.1 0.016 15.1 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDN03064.1 - 0.011 15.2 0.1 0.025 14.0 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Patched PF02460.18 EDN03064.1 - 0.17 9.9 0.0 0.22 9.6 0.0 1.1 1 0 0 1 1 1 0 Patched family RSN1_7TM PF02714.15 EDN03067.1 - 7.4e-90 301.0 17.8 7.4e-90 301.0 17.8 2.9 3 0 0 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDN03067.1 - 2.4e-47 160.6 0.7 2.4e-47 160.6 0.7 3.4 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDN03067.1 - 4.2e-38 131.3 0.6 6.9e-38 130.6 0.6 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDN03067.1 - 1.2e-30 105.5 0.2 1.7e-29 101.9 0.1 2.5 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter CRPA PF05745.11 EDN03067.1 - 0.037 14.1 0.0 0.17 11.9 0.0 2.2 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Pelovaterin PF17859.1 EDN03067.1 - 0.13 12.5 1.1 0.38 11.1 1.1 1.7 1 0 0 1 1 1 0 Pelovaterin La_HTH_kDCL PF18177.1 EDN03068.1 - 0.077 13.3 0.1 0.56 10.5 0.0 2.2 2 0 0 2 2 2 0 La HTH in kinetoplastid DICER domain MCM PF00493.23 EDN03069.1 - 1.2e-99 331.9 0.1 1.8e-99 331.4 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM6_C PF18263.1 EDN03069.1 - 7.8e-36 122.6 5.3 1.8e-35 121.5 5.3 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EDN03069.1 - 7.6e-25 87.2 1.3 1.2e-24 86.5 0.2 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_OB PF17207.3 EDN03069.1 - 9.4e-25 86.9 0.2 1.2e-17 63.9 0.0 2.6 1 1 1 2 2 2 2 MCM OB domain MCM_N PF14551.6 EDN03069.1 - 2.5e-21 76.2 2.0 7.9e-21 74.6 0.4 2.6 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDN03069.1 - 1e-05 25.0 0.0 0.00018 21.0 0.0 2.8 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDN03069.1 - 0.0028 17.7 0.0 0.012 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDN03069.1 - 0.0034 17.3 0.0 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDN03069.1 - 0.0035 17.1 0.0 0.0086 15.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Helicase_C PF00271.31 EDN03070.1 - 6.1e-07 29.8 0.0 1.5e-06 28.5 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain FNIP_N PF14636.6 EDN03072.1 - 5.9e-27 95.5 2.1 5.9e-27 95.5 2.1 4.2 4 2 2 6 6 6 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 EDN03072.1 - 0.025 14.6 1.0 0.088 12.8 0.3 2.1 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain IML1 PF12257.8 EDN03073.1 - 3.9e-98 328.1 0.0 1.6e-97 326.1 0.0 1.8 2 0 0 2 2 2 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EDN03073.1 - 1.2e-28 99.0 0.8 2.4e-28 98.0 0.8 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Fungal_trans PF04082.18 EDN03075.1 - 7.4e-25 87.5 0.3 1.1e-24 87.0 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain SH3_9 PF14604.6 EDN03076.1 - 1.7e-05 24.6 0.2 3.7e-05 23.5 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDN03076.1 - 0.00044 19.8 0.1 0.00083 18.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain PAG PF15347.6 EDN03076.1 - 0.0052 15.9 0.5 0.83 8.6 0.0 2.2 2 0 0 2 2 2 2 Phosphoprotein associated with glycosphingolipid-enriched EphA2_TM PF14575.6 EDN03076.1 - 0.093 13.6 0.0 0.17 12.8 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain She9_MDM33 PF05546.11 EDN03077.1 - 1.8e-05 24.7 0.5 2.9e-05 24.0 0.5 1.3 1 0 0 1 1 1 1 She9 / Mdm33 family She9_MDM33 PF05546.11 EDN03078.1 - 7.9e-77 257.5 7.0 1.2e-76 257.0 7.0 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family PsbH PF00737.20 EDN03078.1 - 0.086 12.6 4.7 0.086 12.6 0.8 2.2 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein Alanine_zipper PF11839.8 EDN03078.1 - 1.4 9.3 7.5 1.5 9.2 2.3 2.6 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Rieske PF00355.26 EDN03079.1 - 1.9e-11 43.8 0.0 3e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EDN03079.1 - 6.1e-11 42.6 1.0 1.5e-10 41.4 1.0 1.7 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Peptidase_M61 PF05299.12 EDN03079.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 M61 glycyl aminopeptidase FeoB_C PF07664.12 EDN03079.1 - 0.2 11.4 0.3 0.72 9.6 0.1 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus CBFD_NFYB_HMF PF00808.23 EDN03080.1 - 3.5e-11 43.2 0.7 8.1e-11 42.0 0.7 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Calcipressin PF04847.12 EDN03080.1 - 0.00036 20.3 0.1 0.0005 19.9 0.1 1.2 1 0 0 1 1 1 1 Calcipressin GP44 PF17510.2 EDN03080.1 - 0.012 15.8 0.2 0.026 14.8 0.0 1.6 2 0 0 2 2 2 0 Gene product 44 Histone PF00125.24 EDN03080.1 - 0.14 12.5 0.2 0.14 12.5 0.2 2.0 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Voltage_CLC PF00654.20 EDN03081.1 - 2.1e-38 132.5 11.3 2.1e-38 132.5 11.3 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EDN03082.1 - 2.5e-12 47.0 0.0 7.5e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 CBS domain EamA PF00892.20 EDN03083.1 - 6.5e-05 23.1 16.6 0.00033 20.8 16.6 1.8 1 1 0 1 1 1 1 EamA-like transporter family DUF2632 PF10943.8 EDN03083.1 - 0.012 15.2 0.7 0.016 14.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2632) PPR_2 PF13041.6 EDN03084.1 - 2.8e-45 152.3 9.9 3.5e-09 36.7 0.0 11.7 8 4 4 12 12 12 7 PPR repeat family PPR_3 PF13812.6 EDN03084.1 - 2.5e-31 107.6 0.2 0.00048 20.1 0.3 10.2 8 2 2 10 10 10 6 Pentatricopeptide repeat domain PPR PF01535.20 EDN03084.1 - 1.7e-29 100.0 10.3 0.00096 19.2 0.0 12.8 14 0 0 14 14 14 5 PPR repeat PPR_1 PF12854.7 EDN03084.1 - 4.7e-23 80.6 0.2 1.9e-06 27.5 0.0 10.1 10 0 0 10 10 10 4 PPR repeat PPR_long PF17177.4 EDN03084.1 - 2e-19 69.8 6.3 1.8e-07 30.7 0.0 5.4 2 2 3 6 6 6 6 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 EDN03084.1 - 1.2e-08 35.4 0.0 2.5e-05 24.6 0.0 4.5 5 0 0 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) TPR_14 PF13428.6 EDN03084.1 - 1.2e-06 28.9 2.1 22 6.2 0.0 8.7 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDN03084.1 - 0.0027 18.2 1.3 0.96 10.0 0.1 5.4 7 1 0 7 7 7 1 Tetratricopeptide repeat BTAD PF03704.17 EDN03084.1 - 0.018 15.5 0.9 2.4 8.6 0.1 3.9 2 1 1 3 3 3 0 Bacterial transcriptional activator domain ATP13 PF12921.7 EDN03084.1 - 0.018 14.9 0.2 32 4.4 0.0 4.4 4 2 0 5 5 5 0 Mitochondrial ATPase expression ECSIT PF06239.11 EDN03084.1 - 0.027 13.6 0.0 13 4.9 0.0 3.8 4 0 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway DUF1542 PF07564.11 EDN03084.1 - 0.027 14.6 1.2 0.062 13.4 1.2 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF2960 PF11173.8 EDN03084.1 - 0.29 11.6 1.8 4.2 7.9 0.1 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF2960) GHMP_kinases_N PF00288.26 EDN03085.1 - 1.1e-13 51.2 0.7 1.1e-13 51.2 0.7 2.8 3 0 0 3 3 3 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDN03085.1 - 1.4e-09 38.2 0.0 3.5e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal MIB_HERC2 PF06701.13 EDN03085.1 - 0.02 15.1 0.1 0.045 14.0 0.1 1.6 1 0 0 1 1 1 0 Mib_herc2 Rad60-SLD_2 PF13881.6 EDN03086.1 - 3.3e-10 40.1 0.0 8.7e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDN03086.1 - 0.011 16.3 0.1 0.051 14.1 0.0 2.1 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EDN03086.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin family SOG2 PF10428.9 EDN03086.1 - 0.63 9.2 24.4 0.83 8.8 24.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Presenilin PF01080.17 EDN03086.1 - 6.1 5.5 8.7 8.2 5.1 8.7 1.1 1 0 0 1 1 1 0 Presenilin UMP1 PF05348.11 EDN03087.1 - 6.5e-41 139.3 0.1 7.9e-41 139.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Ribosom_S12_S23 PF00164.25 EDN03088.1 - 1.6e-25 89.0 0.1 2.4e-25 88.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Glyco_transf_15 PF01793.16 EDN03089.1 - 1.6e-125 418.7 13.8 1.9e-125 418.4 13.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PAT1 PF09770.9 EDN03090.1 - 0 1118.0 13.9 0 1027.2 0.2 2.0 1 1 1 2 2 2 2 Topoisomerase II-associated protein PAT1 GDP_Man_Dehyd PF16363.5 EDN03091.1 - 6.8e-33 114.4 0.0 1.7e-21 77.0 0.0 2.2 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EDN03091.1 - 6.6e-29 101.1 0.1 6.3e-23 81.5 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN03091.1 - 2e-11 43.4 0.0 2.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EDN03091.1 - 6.6e-07 28.8 0.0 1.2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDN03091.1 - 8.6e-06 25.3 0.0 1.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03091.1 - 1.6e-05 24.6 0.0 2.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EDN03091.1 - 0.0002 21.3 0.0 0.00034 20.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EDN03091.1 - 0.00033 19.9 0.0 0.00044 19.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EDN03091.1 - 0.0048 16.8 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 KR domain UDPG_MGDP_dh_N PF03721.14 EDN03091.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short PF00106.25 EDN03092.1 - 9.2e-14 51.4 0.0 4.8e-11 42.5 0.0 2.3 1 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDN03092.1 - 1.5e-06 28.3 0.0 3.6e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EDN03092.1 - 6.7e-06 25.8 0.0 0.00012 21.7 0.0 2.4 2 1 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EDN03092.1 - 0.035 13.6 0.0 0.16 11.4 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family G-patch PF01585.23 EDN03093.1 - 1.8e-05 24.6 0.9 3.3e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 G-patch domain DNA_pol_E_B PF04042.16 EDN03093.1 - 0.12 11.7 2.9 0.18 11.1 2.3 1.4 1 1 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Sec1 PF00995.23 EDN03094.1 - 7.7e-50 170.7 0.0 1.1e-47 163.6 0.0 2.1 1 1 0 1 1 1 1 Sec1 family Sec1 PF00995.23 EDN03095.1 - 1.4e-12 47.7 0.2 1.6e-12 47.5 0.2 1.0 1 0 0 1 1 1 1 Sec1 family SUV3_C PF12513.8 EDN03096.1 - 3.5e-16 58.9 0.1 9.3e-16 57.5 0.1 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 EDN03096.1 - 1.4e-12 47.2 0.7 2.2e-12 46.6 0.1 1.7 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 EDN03096.1 - 8.4e-07 29.3 0.0 2.4e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4771 PF15995.5 EDN03096.1 - 0.02 15.1 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) HA2 PF04408.23 EDN03097.1 - 1.4e-25 89.7 0.9 3.6e-25 88.4 0.1 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDN03097.1 - 4.3e-20 71.8 0.0 8.7e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDN03097.1 - 2.4e-13 50.4 0.0 6.4e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EDN03097.1 - 1.3e-10 41.4 1.0 1.3e-10 41.4 1.0 1.8 2 0 0 2 2 2 1 S1 RNA binding domain DEAD PF00270.29 EDN03097.1 - 3e-05 23.9 0.5 9.9e-05 22.2 0.5 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EDN03097.1 - 0.00077 18.6 0.0 0.0016 17.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EDN03097.1 - 0.0019 18.4 0.1 0.0069 16.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN03097.1 - 0.0028 17.4 0.1 0.0089 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDN03097.1 - 0.043 14.1 0.1 0.092 13.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain Microtub_bd PF16796.5 EDN03097.1 - 0.13 12.2 0.1 3.4 7.6 0.1 2.4 2 0 0 2 2 2 0 Microtubule binding Npa1 PF11707.8 EDN03099.1 - 3.6e-96 322.5 0.6 8.1e-96 321.3 0.0 1.9 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EDN03099.1 - 1.4e-23 83.6 3.7 4.6e-23 81.9 0.0 3.3 3 1 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Creb_binding PF09030.10 EDN03099.1 - 0.048 14.4 1.7 0.61 10.8 0.0 2.9 2 0 0 2 2 2 0 Creb binding Eaf7 PF07904.13 EDN03101.1 - 7.3 7.0 10.3 1.5 9.3 5.8 2.2 2 1 0 2 2 2 0 Chromatin modification-related protein EAF7 UPRTase PF14681.6 EDN03102.1 - 1.7e-40 138.7 0.0 3.1e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EDN03102.1 - 6.7e-35 120.6 0.0 1.1e-34 120.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EDN03102.1 - 2e-06 28.4 0.0 4.7e-06 27.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain CPT PF07931.12 EDN03102.1 - 8.6e-06 25.7 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 EDN03102.1 - 0.0024 17.2 0.0 0.0071 15.6 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin Cytidylate_kin PF02224.18 EDN03102.1 - 0.038 13.7 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase Gpi16 PF04113.14 EDN03102.1 - 0.097 11.1 0.0 0.37 9.2 0.0 1.8 2 0 0 2 2 2 0 Gpi16 subunit, GPI transamidase component DUF87 PF01935.17 EDN03102.1 - 0.13 12.3 0.4 0.25 11.4 0.4 1.7 1 1 0 1 1 1 0 Helicase HerA, central domain CLTH PF10607.9 EDN03103.1 - 2.3e-35 121.7 0.1 2.9e-35 121.3 0.1 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EDN03103.1 - 2.2e-09 36.9 0.0 3.9e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 LisH TRM13 PF05206.14 EDN03103.1 - 0.06 12.9 0.2 0.083 12.4 0.2 1.2 1 0 0 1 1 1 0 Methyltransferase TRM13 Pyr_redox_2 PF07992.14 EDN03104.1 - 4.7e-38 131.1 0.0 6.6e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN03104.1 - 1e-11 45.2 0.0 8.7e-10 39.0 0.0 3.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EDN03104.1 - 3e-07 29.5 0.1 1.2e-06 27.7 0.2 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EDN03104.1 - 2.9e-06 26.7 0.3 1.1e-05 25.0 0.3 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 EDN03104.1 - 1.1e-05 24.7 0.5 3e-05 23.3 0.5 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EDN03104.1 - 0.00024 21.5 0.5 0.0009 19.6 0.4 2.0 1 1 0 1 1 1 1 EF-hand domain pair Nipped-B_C PF12830.7 EDN03105.1 - 1.3e-33 116.6 3.7 1.1e-32 113.5 0.1 3.4 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EDN03105.1 - 1.9e-11 44.0 2.7 1.9e-11 44.0 2.7 2.3 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 EDN03105.1 - 3e-05 23.9 2.8 0.83 10.1 0.1 5.6 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EDN03105.1 - 0.0005 20.1 6.4 0.3 11.1 0.0 3.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDN03105.1 - 0.011 14.4 6.8 0.032 12.8 1.0 3.5 3 1 1 4 4 4 0 Adaptin N terminal region Cnd3 PF12719.7 EDN03105.1 - 0.03 13.5 5.5 2.2 7.4 0.5 3.5 3 1 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain Sec7_N PF12783.7 EDN03105.1 - 0.18 11.7 7.2 0.25 11.3 0.4 4.0 3 1 1 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal ABC2_membrane PF01061.24 EDN03106.1 - 4.4e-81 271.3 59.6 7e-42 143.2 22.3 2.6 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EDN03106.1 - 3.1e-21 76.3 0.0 6.6e-14 52.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 EDN03106.1 - 5.3e-21 75.0 0.0 1.2e-20 73.9 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal PDR_CDR PF06422.12 EDN03106.1 - 1.7e-09 37.5 8.3 2.3e-05 24.2 0.0 4.0 4 0 0 4 4 4 2 CDR ABC transporter TMEM215 PF15746.5 EDN03106.1 - 0.016 14.7 0.6 0.016 14.7 0.6 2.0 2 0 0 2 2 2 0 TMEM215 family DUF3220 PF11516.8 EDN03106.1 - 0.039 14.2 0.0 0.35 11.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3120) HEAT_2 PF13646.6 EDN03107.1 - 1.3e-27 96.0 3.9 3.6e-14 52.9 0.5 3.7 2 2 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.16 EDN03107.1 - 2e-18 65.1 2.2 0.0038 17.8 0.0 6.4 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.22 EDN03107.1 - 3.9e-06 26.7 6.5 1.3 9.5 0.0 6.7 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.6 EDN03107.1 - 0.065 13.8 8.3 16 6.2 0.0 5.1 3 3 4 7 7 7 0 HEAT-like repeat Arm PF00514.23 EDN03107.1 - 0.076 13.1 1.9 17 5.6 0.0 4.1 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat ETC_C1_NDUFA4 PF04800.12 EDN03108.1 - 1.1e-37 128.2 2.2 1.6e-37 127.7 2.2 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region F1F0-ATPsyn_F PF10791.9 EDN03109.1 - 9e-42 141.5 0.1 1e-41 141.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi S-antigen PF05756.11 EDN03110.1 - 5.2 7.5 5.7 0.44 11.0 0.2 2.0 2 0 0 2 2 2 0 S-antigen protein MOZ_SAS PF01853.18 EDN03111.1 - 5.1e-80 267.3 0.0 7.6e-80 266.8 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.8 EDN03111.1 - 6.7e-23 80.3 0.0 1.3e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-MYST PF17772.1 EDN03111.1 - 6.8e-23 80.0 0.5 1.3e-22 79.1 0.5 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Agenet PF05641.12 EDN03111.1 - 0.0015 18.9 0.0 0.0038 17.7 0.0 1.6 1 0 0 1 1 1 1 Agenet domain Acetyltransf_7 PF13508.7 EDN03111.1 - 0.0043 17.4 0.0 0.0092 16.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN03111.1 - 0.045 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HTH_9 PF08221.11 EDN03111.1 - 0.075 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Myb_Cef PF11831.8 EDN03112.1 - 4.7e-57 193.3 3.5 4.7e-57 193.3 3.5 2.7 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EDN03112.1 - 2.5e-21 75.6 4.3 1.8e-10 40.9 0.6 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN03112.1 - 7.1e-19 67.8 4.0 4.1e-12 46.2 1.1 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EDN03112.1 - 0.091 12.9 0.4 0.94 9.6 0.0 2.7 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Nop53 PF07767.11 EDN03113.1 - 2.5e-103 346.5 31.3 3.1e-103 346.3 31.3 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) RNase_T PF00929.24 EDN03114.1 - 5.8e-17 62.7 0.0 2.1e-16 60.9 0.0 1.8 1 1 0 1 1 1 1 Exonuclease RNase_H2_suC PF08615.11 EDN03115.1 - 1.3e-34 119.4 0.1 1.7e-34 119.0 0.1 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Alk_phosphatase PF00245.20 EDN03116.1 - 2.3e-61 208.0 3.3 7.5e-30 104.2 0.1 2.5 1 1 1 2 2 2 2 Alkaline phosphatase Sulfatase PF00884.23 EDN03116.1 - 1.1e-05 25.0 0.9 6.4e-05 22.5 0.9 2.1 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EDN03116.1 - 0.0002 21.0 0.1 0.00037 20.2 0.1 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase HHH_3 PF12836.7 EDN03116.1 - 0.002 18.4 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF229 PF02995.17 EDN03116.1 - 0.017 13.7 0.2 0.025 13.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 EDN03116.1 - 0.92 8.8 4.2 0.49 9.7 0.2 2.4 3 1 0 3 3 3 0 Metalloenzyme superfamily DcpS PF05652.12 EDN03117.1 - 6.4e-35 120.1 0.0 1.4e-34 119.1 0.0 1.6 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EDN03117.1 - 6.6e-31 107.1 0.0 1e-30 106.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Peptidase_C12 PF01088.21 EDN03118.1 - 3.2e-56 190.4 0.0 3.9e-56 190.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 CH PF00307.31 EDN03118.1 - 0.065 13.4 0.0 16 5.8 0.0 2.2 2 0 0 2 2 2 0 Calponin homology (CH) domain MT-A70 PF05063.14 EDN03119.1 - 5.4e-21 75.3 0.1 2.7e-20 73.0 0.1 2.0 1 1 0 1 1 1 1 MT-A70 tRNA-synt_2 PF00152.20 EDN03120.1 - 6.5e-91 304.7 0.0 8.6e-91 304.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDN03120.1 - 6e-08 32.6 0.0 1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain MFMR_assoc PF16596.5 EDN03122.1 - 0.043 14.3 0.6 0.043 14.3 0.6 2.0 2 0 0 2 2 2 0 Disordered region downstream of MFMR Iwr1 PF08574.10 EDN03125.1 - 6.6e-20 71.9 0.6 6.6e-20 71.9 0.6 3.3 3 2 1 4 4 4 1 Transcription factor Iwr1 Use1 PF09753.9 EDN03125.1 - 0.48 10.1 4.6 0.83 9.3 4.6 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 NAM-associated PF14303.6 EDN03125.1 - 6.6 7.4 13.3 0.28 11.9 6.9 2.0 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain RRM_1 PF00076.22 EDN03127.1 - 4.6e-33 112.9 0.2 1e-11 44.5 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN03127.1 - 4.5e-09 36.0 0.0 0.055 13.3 0.0 3.8 4 0 0 4 4 4 3 Occluded RNA-recognition motif DUF4523 PF15023.6 EDN03127.1 - 3.9e-06 26.8 0.0 0.0072 16.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4523) RRM_7 PF16367.5 EDN03127.1 - 0.00029 20.9 0.0 0.16 12.1 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 EDN03127.1 - 0.0016 18.4 2.6 0.28 11.3 0.1 3.1 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 EDN03127.1 - 0.0081 16.1 0.0 4.4 7.4 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 EDN03127.1 - 0.023 14.7 0.2 0.15 12.1 0.0 2.4 3 0 0 3 3 3 0 RNA binding domain GST_N_3 PF13417.6 EDN03128.1 - 5.2e-09 36.4 0.0 1.1e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDN03128.1 - 1.5e-08 34.8 0.0 3.1e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EDN03128.1 - 5.2e-07 29.9 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain YL1 PF05764.13 EDN03129.1 - 1.3e-23 84.4 21.7 1.5e-23 84.2 21.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein SEEEED PF14797.6 EDN03129.1 - 0.95 9.6 19.9 0.27 11.4 14.3 2.1 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex PUF PF00806.19 EDN03130.1 - 1.4e-29 100.1 0.0 1.1e-05 24.8 0.0 6.0 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EDN03130.1 - 5.4e-10 38.9 0.0 2.3e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAP59_mtransfer PF11735.8 EDN03131.1 - 4.4e-66 223.0 0.0 5.8e-66 222.6 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DUF1349 PF07081.11 EDN03132.1 - 9.8e-29 100.3 0.0 1.2e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) ParA PF10609.9 EDN03133.1 - 8.8e-96 320.1 0.0 1e-95 319.9 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDN03133.1 - 4.8e-07 29.9 0.0 1.4e-06 28.4 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 EDN03133.1 - 1e-06 28.2 0.7 8.1e-05 21.9 0.2 2.8 1 1 1 3 3 3 1 Anion-transporting ATPase AAA_31 PF13614.6 EDN03133.1 - 4.6e-06 26.7 0.0 1.7e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EDN03133.1 - 0.007 15.7 0.0 0.014 14.7 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 EDN03133.1 - 0.0077 16.1 0.0 1.2 9.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDN03133.1 - 0.0077 16.0 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDN03133.1 - 0.015 15.2 0.1 0.033 14.1 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase CLP1_P PF16575.5 EDN03133.1 - 0.019 14.8 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_helicase PF00910.22 EDN03133.1 - 0.14 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EDN03133.1 - 0.15 11.6 0.1 0.29 10.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDN03133.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDN03133.1 - 0.2 12.2 0.1 0.31 11.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain Asp PF00026.23 EDN03135.1 - 1.4e-60 205.4 0.1 1.7e-60 205.1 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDN03135.1 - 5.1e-10 39.9 0.2 0.00034 20.9 0.2 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDN03135.1 - 2.6e-07 31.2 1.8 0.003 18.1 0.2 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDN03135.1 - 0.0058 17.2 0.3 1.4 9.5 0.1 3.1 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease p450 PF00067.22 EDN03136.1 - 1.9e-46 158.8 0.0 4.1e-42 144.5 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Pkinase_fungal PF17667.1 EDN03137.1 - 6.1e-73 245.9 2.1 3e-57 194.3 0.0 3.6 2 1 2 4 4 4 3 Fungal protein kinase Pkinase PF00069.25 EDN03137.1 - 1.7e-06 27.6 0.0 3.3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Anp1 PF03452.14 EDN03138.1 - 8.3e-81 271.3 1.2 2.1e-80 270.0 0.0 1.9 2 0 0 2 2 2 1 Anp1 G6PD_bact PF10786.9 EDN03138.1 - 0.08 12.5 5.1 0.23 11.0 2.8 2.4 2 1 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Dcc1 PF09724.9 EDN03139.1 - 4.8e-20 72.1 0.0 7e-13 48.6 0.0 2.1 2 0 0 2 2 2 2 Sister chromatid cohesion protein Dcc1 DUF5490 PF17593.2 EDN03140.1 - 2.5 8.2 5.0 0.5 10.4 0.5 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5490) ThiF PF00899.21 EDN03141.1 - 1.6e-86 289.6 0.0 1.6e-33 116.1 0.0 3.2 2 1 1 3 3 3 3 ThiF family UBA_e1_thiolCys PF10585.9 EDN03141.1 - 3.5e-64 217.1 0.2 2.8e-54 184.7 0.0 3.0 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EDN03141.1 - 6.3e-27 93.6 0.2 1.4e-26 92.4 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EDN03141.1 - 7.1e-25 87.5 0.1 1.4e-24 86.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EDN03141.1 - 1.3e-24 86.2 0.0 3.3e-24 84.9 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle GST_N_2 PF13409.6 EDN03142.1 - 5.2e-19 68.3 0.1 2.1e-18 66.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDN03142.1 - 1.8e-14 53.5 0.0 4.7e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDN03142.1 - 2.1e-06 27.9 0.0 1e-05 25.6 0.0 1.9 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDN03142.1 - 0.031 14.5 0.0 0.066 13.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Amidohydro_1 PF01979.20 EDN03143.1 - 4e-21 75.7 0.4 1.1e-10 41.4 0.0 3.0 2 1 1 3 3 3 2 Amidohydrolase family Amidohydro_3 PF07969.11 EDN03143.1 - 5.1e-16 59.2 0.9 3.2e-08 33.5 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family Mito_carr PF00153.27 EDN03144.1 - 2e-55 184.7 5.2 1.1e-23 82.9 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EDN03144.1 - 2.4e-17 63.1 8.0 3.2e-10 40.3 1.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDN03144.1 - 3.3e-17 60.7 7.1 8.8e-06 24.9 1.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EDN03144.1 - 7.6e-17 59.8 6.7 0.00015 21.4 0.0 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EDN03144.1 - 3.6e-14 51.5 5.4 0.00036 19.9 0.7 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EDN03144.1 - 5.5e-11 42.1 4.9 3.5e-05 23.6 0.2 3.0 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EDN03144.1 - 1.2e-06 28.8 0.6 0.0015 18.8 0.1 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EDN03144.1 - 0.0045 16.9 4.6 0.37 10.8 0.1 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand MIP PF00230.20 EDN03145.1 - 2.8e-16 59.9 3.2 3.7e-16 59.5 3.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein HIRAN PF08797.11 EDN03148.1 - 0.029 14.3 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 HIRAN domain NYD-SP28 PF14772.6 EDN03148.1 - 0.076 13.1 0.4 0.11 12.5 0.4 1.2 1 0 0 1 1 1 0 Sperm tail zf-TRAF PF02176.18 EDN03149.1 - 9.9e-10 39.0 36.2 1.5e-06 28.8 14.2 3.8 1 1 3 4 4 4 3 TRAF-type zinc finger zf-TRAF_2 PF15965.5 EDN03149.1 - 0.013 16.0 28.7 0.033 14.7 17.9 2.4 1 1 0 2 2 2 0 TRAF-like zinc-finger bZIP_2 PF07716.15 EDN03149.1 - 0.04 14.0 0.7 0.15 12.2 0.2 2.1 2 0 0 2 2 2 0 Basic region leucine zipper CorA PF01544.18 EDN03149.1 - 0.15 11.4 0.0 5.1 6.3 0.1 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein FlaC_arch PF05377.11 EDN03149.1 - 0.42 11.0 3.0 24 5.4 0.2 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) zf_C2HC_14 PF18574.1 EDN03149.1 - 6.3 6.7 18.1 0.053 13.3 4.2 3.3 3 0 0 3 3 3 0 C2HC Zing finger domain Het-C PF07217.11 EDN03150.1 - 1.4e-224 746.8 0.0 7.1e-193 642.2 0.0 2.1 2 0 0 2 2 2 2 Heterokaryon incompatibility protein Het-C GCP_N_terminal PF17681.1 EDN03151.1 - 1.4e-32 113.6 0.0 3e-32 112.5 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDN03151.1 - 3.4e-22 79.3 0.0 6.4e-22 78.4 0.0 1.4 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Nup214_FG PF18617.1 EDN03151.1 - 0.21 12.1 0.4 20 5.8 0.1 2.4 2 0 0 2 2 2 0 Nucleoporin Nup214 phenylalanine-glycine (FG) domain MFS_1 PF07690.16 EDN03152.1 - 4.1e-30 104.9 17.2 4.1e-30 104.9 17.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDN03152.1 - 0.76 8.6 17.8 0.048 12.5 6.2 3.1 2 2 1 3 3 3 0 MFS_1 like family APH PF01636.23 EDN03153.1 - 3.9e-13 49.9 0.0 8.1e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family GILT PF03227.16 EDN03156.1 - 2.6e-08 34.1 0.0 6.6e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Zap1_zf2 PF18217.1 EDN03156.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Zap1 zinc finger 2 Hexokinase_2 PF03727.16 EDN03157.1 - 9.7e-47 159.4 0.0 9.9e-45 152.8 0.0 2.2 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDN03157.1 - 4.6e-38 131.1 0.0 1.2e-23 84.1 0.0 2.2 2 0 0 2 2 2 2 Hexokinase TFIIA_gamma_C PF02751.14 EDN03158.1 - 1.8e-25 88.8 1.8 1.8e-25 88.8 1.8 1.6 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EDN03158.1 - 1.7e-24 85.5 0.1 2.4e-24 85.1 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain SAB PF04382.13 EDN03159.1 - 0.0032 17.5 0.1 0.014 15.5 0.1 2.1 1 0 0 1 1 1 1 SAB domain Aldedh PF00171.22 EDN03161.1 - 1.9e-120 402.5 0.0 2.3e-120 402.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EDN03161.1 - 1.7e-05 24.1 0.0 5.4e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) Methyltransf_33 PF10017.9 EDN03162.1 - 7.2e-69 232.3 0.0 1.3e-68 231.5 0.0 1.4 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 EDN03162.1 - 1e-19 71.1 0.5 6.4e-10 39.0 0.1 2.5 3 0 0 3 3 3 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EDN03162.1 - 0.0089 16.5 0.3 0.041 14.4 0.1 2.3 2 1 0 2 2 2 1 DinB superfamily YcxB PF14317.6 EDN03162.1 - 0.046 13.4 0.0 5 6.9 0.0 3.1 3 0 0 3 3 3 0 YcxB-like protein DUF92 PF01940.16 EDN03163.1 - 3.8e-85 285.1 1.8 4.7e-85 284.8 1.8 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 NrsF PF06532.11 EDN03163.1 - 0.22 11.2 6.4 2.4 7.8 1.5 2.7 2 0 0 2 2 2 0 Negative regulator of sigma F DUF3878 PF12994.7 EDN03164.1 - 0.14 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3878) 4HBT PF03061.22 EDN03165.1 - 7.1e-09 35.9 0.0 4.6e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 Thioesterase superfamily RNA_pol PF00940.19 EDN03166.1 - 2.8e-183 609.5 0.0 4.3e-183 608.9 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EDN03166.1 - 1.3e-95 320.7 0.2 1.3e-95 320.7 0.2 1.5 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal ABC_tran_Xtn PF12848.7 EDN03166.1 - 9.3 6.4 9.4 9 6.4 0.4 3.3 3 0 0 3 3 3 0 ABC transporter Sin_N PF04801.13 EDN03167.1 - 4.9e-11 42.5 0.0 6.1e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Sin-like protein conserved region NIR_SIR PF01077.22 EDN03168.1 - 0.00097 18.7 0.0 0.0013 18.3 0.0 1.1 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain POR_N PF01855.19 EDN03169.1 - 3.4e-09 36.8 0.0 5.6e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg TFIIE_beta PF02186.15 EDN03171.1 - 0.045 14.1 1.2 1.2 9.4 0.0 2.8 3 0 0 3 3 3 0 TFIIE beta subunit core domain CotJB PF12652.7 EDN03171.1 - 0.66 10.2 4.3 1.6 9.0 0.1 3.2 2 1 1 3 3 3 0 CotJB protein RVT_1 PF00078.27 EDN03172.1 - 2.2e-32 112.4 0.0 3.8e-32 111.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN03172.1 - 0.046 13.5 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Integrase_H2C2 PF17921.1 EDN03173.1 - 1.3e-20 73.2 1.0 2.1e-20 72.6 1.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EDN03173.1 - 0.00022 21.4 0.0 0.00041 20.5 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger FEZ PF07763.13 EDN03173.1 - 0.14 11.9 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 FEZ-like protein PKcGMP_CC PF16808.5 EDN03173.1 - 3.7 7.5 4.6 0.86 9.5 0.3 2.2 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Pkinase_fungal PF17667.1 EDN03175.1 - 7.9e-29 100.6 0.0 1.1e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase adh_short PF00106.25 EDN03175.1 - 2.6e-26 92.3 0.9 3.1e-13 49.6 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDN03175.1 - 7.7e-19 68.3 3.4 5.4e-12 46.0 0.1 2.3 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.6 EDN03175.1 - 1.5e-15 57.4 0.2 4.3e-09 36.3 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Pkinase_fungal PF17667.1 EDN03176.1 - 1.3e-37 129.5 0.1 5.7e-31 107.7 0.1 2.1 1 1 1 2 2 2 2 Fungal protein kinase Picorna_P3A PF06363.11 EDN03176.1 - 0.18 11.7 0.1 0.55 10.1 0.0 1.8 2 0 0 2 2 2 0 Picornaviridae P3A protein Ras PF00071.22 EDN03177.1 - 7e-54 181.8 0.2 3e-53 179.7 0.2 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDN03177.1 - 6.9e-34 116.6 0.1 1.2e-32 112.6 0.1 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN03177.1 - 6.3e-15 55.1 0.2 4.3e-13 49.1 0.2 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN03177.1 - 5.6e-05 22.8 0.0 0.00026 20.6 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDN03177.1 - 0.0002 21.3 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDN03177.1 - 0.00031 20.8 0.0 0.00067 19.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDN03177.1 - 0.021 14.2 0.1 0.093 12.1 0.1 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDN03177.1 - 0.026 14.0 0.0 0.27 10.7 0.0 2.2 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TIR_2 PF13676.6 EDN03177.1 - 0.066 13.8 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 TIR domain DDHD PF02862.17 EDN03178.1 - 5.2e-17 62.7 0.0 3.3e-16 60.1 0.0 2.1 1 1 0 1 1 1 1 DDHD domain LIDHydrolase PF10230.9 EDN03178.1 - 0.017 14.7 0.2 0.03 13.9 0.2 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF900 PF05990.12 EDN03178.1 - 0.063 12.8 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EDN03178.1 - 0.094 13.3 0.0 0.16 12.5 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Collagen PF01391.18 EDN03178.1 - 0.13 12.1 1.0 0.19 11.5 1.0 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) FAD_binding_3 PF01494.19 EDN03180.1 - 6.8e-12 45.3 0.0 8.3e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.19 EDN03180.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Apis_Csd PF11671.8 EDN03181.1 - 0.22 11.5 14.8 0.24 11.4 14.8 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein LSM PF01423.22 EDN03185.1 - 6.1e-21 73.9 0.2 7.2e-21 73.7 0.2 1.1 1 0 0 1 1 1 1 LSM domain APH PF01636.23 EDN03186.1 - 9.9e-09 35.5 0.0 1.6e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3431 PF11913.8 EDN03187.1 - 1.1e-34 120.1 0.0 1.4e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Ras PF00071.22 EDN03189.1 - 2.6e-30 105.1 0.0 3.4e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN03189.1 - 8.9e-16 58.2 0.0 1.3e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN03189.1 - 0.00012 21.6 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EDN03189.1 - 0.014 14.9 0.1 0.022 14.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 EDN03189.1 - 0.023 14.1 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PAP2 PF01569.21 EDN03190.1 - 2.9e-14 53.0 2.9 2.9e-14 53.0 2.9 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EDN03190.1 - 3.4 7.3 7.6 0.17 11.6 1.8 1.8 2 0 0 2 2 2 0 PAP2 superfamily E1-E2_ATPase PF00122.20 EDN03192.1 - 9.7e-50 168.6 0.8 9.7e-50 168.6 0.8 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDN03192.1 - 3.6e-22 79.7 0.0 1.5e-21 77.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDN03192.1 - 2.6e-08 33.9 0.1 5.5e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDN03192.1 - 0.0014 19.0 0.0 0.0038 17.7 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1980 PF09323.10 EDN03192.1 - 0.027 14.4 0.0 0.076 12.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF1664 PF07889.12 EDN03195.1 - 9.4e-05 22.5 6.9 0.16 12.0 0.1 3.7 2 1 2 4 4 4 2 Protein of unknown function (DUF1664) Atg14 PF10186.9 EDN03195.1 - 0.00017 20.8 4.7 0.00027 20.1 4.7 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 LPP PF04728.13 EDN03195.1 - 0.00091 19.6 11.8 0.012 16.0 2.1 3.8 2 1 2 4 4 3 2 Lipoprotein leucine-zipper Spc7 PF08317.11 EDN03195.1 - 0.00096 18.1 1.8 0.0017 17.3 1.8 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein ADIP PF11559.8 EDN03195.1 - 0.0015 18.6 4.8 0.0015 18.6 4.8 1.8 2 0 0 2 2 1 1 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 EDN03195.1 - 0.0018 18.8 2.4 0.0018 18.8 2.4 1.6 2 0 0 2 2 1 1 Apg6 coiled-coil region COG5 PF10392.9 EDN03195.1 - 0.0033 17.6 3.5 0.0033 17.6 3.5 2.1 3 0 0 3 3 1 1 Golgi transport complex subunit 5 Fez1 PF06818.15 EDN03195.1 - 0.0034 17.9 6.3 0.01 16.3 6.5 1.7 1 1 1 2 2 2 1 Fez1 WEMBL PF05701.11 EDN03195.1 - 0.012 14.4 0.6 0.019 13.7 0.6 1.3 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Prominin PF05478.11 EDN03195.1 - 0.013 13.4 3.1 0.017 13.1 3.1 1.2 1 0 0 1 1 1 0 Prominin HMMR_C PF15908.5 EDN03195.1 - 0.017 15.4 2.6 0.2 11.9 0.4 2.5 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal KASH_CCD PF14662.6 EDN03195.1 - 0.019 14.8 5.7 0.033 14.0 4.4 1.9 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH HsbA PF12296.8 EDN03195.1 - 0.025 15.0 0.6 0.067 13.6 0.6 1.7 1 1 0 1 1 1 0 Hydrophobic surface binding protein A GAS PF13851.6 EDN03195.1 - 0.026 13.9 2.0 0.049 13.0 2.0 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HAP1_N PF04849.13 EDN03195.1 - 0.026 13.7 5.6 0.044 13.0 5.6 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF2730 PF10805.8 EDN03195.1 - 0.026 14.6 5.4 0.34 11.0 3.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) EzrA PF06160.12 EDN03195.1 - 0.029 12.6 2.2 0.054 11.7 1.7 1.6 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA CENP-F_leu_zip PF10473.9 EDN03195.1 - 0.032 14.3 5.3 0.085 12.9 2.2 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 EDN03195.1 - 0.033 13.7 3.5 0.063 12.7 3.5 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF724 PF05266.14 EDN03195.1 - 0.034 14.0 0.5 0.085 12.7 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Baculo_PEP_C PF04513.12 EDN03195.1 - 0.05 13.7 8.3 0.22 11.6 8.4 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus VPS38 PF17649.1 EDN03195.1 - 0.05 12.5 1.9 0.069 12.0 1.9 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting 38 bZIP_2 PF07716.15 EDN03195.1 - 0.052 13.6 0.9 15 5.8 0.2 2.9 2 0 0 2 2 2 0 Basic region leucine zipper ArAE_2_N PF10337.9 EDN03195.1 - 0.065 12.3 0.2 0.085 11.9 0.2 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal HAUS-augmin3 PF14932.6 EDN03195.1 - 0.093 12.3 4.5 0.057 13.0 2.5 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4472 PF14739.6 EDN03195.1 - 0.1 13.3 4.5 0.14 12.9 1.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Corona_S2 PF01601.16 EDN03195.1 - 0.12 10.8 1.7 0.17 10.3 1.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein CASP_C PF08172.12 EDN03195.1 - 0.14 11.4 4.3 1.1 8.6 0.3 2.8 1 1 2 3 3 3 0 CASP C terminal Macoilin PF09726.9 EDN03195.1 - 0.19 10.3 11.0 0.016 13.8 5.6 1.7 1 1 1 2 2 2 0 Macoilin family Plasmid_RAQPRD PF09686.10 EDN03195.1 - 0.21 11.8 6.2 13 6.1 0.0 3.6 2 1 1 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) RasGAP_C PF03836.15 EDN03195.1 - 0.22 11.7 4.0 0.65 10.1 4.0 1.9 1 1 0 1 1 1 0 RasGAP C-terminus DUF4618 PF15397.6 EDN03195.1 - 0.23 10.9 8.8 0.27 10.6 2.3 2.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4618) MscS_porin PF12795.7 EDN03195.1 - 0.32 10.5 13.0 0.02 14.4 7.8 1.6 2 0 0 2 2 1 0 Mechanosensitive ion channel porin domain CEP63 PF17045.5 EDN03195.1 - 0.32 10.9 9.4 0.038 13.9 5.4 1.4 2 0 0 2 2 1 0 Centrosomal protein of 63 kDa DivIC PF04977.15 EDN03195.1 - 0.4 10.5 2.8 10 5.9 0.1 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF4795 PF16043.5 EDN03195.1 - 0.43 10.2 8.3 0.96 9.0 8.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF948 PF06103.11 EDN03195.1 - 0.44 10.8 3.7 0.95 9.8 2.6 2.0 1 1 1 2 2 1 0 Bacterial protein of unknown function (DUF948) TolA_bind_tri PF16331.5 EDN03195.1 - 0.54 10.4 12.5 2 8.6 5.8 2.9 1 1 1 2 2 2 0 TolA binding protein trimerisation Jnk-SapK_ap_N PF09744.9 EDN03195.1 - 0.59 10.4 8.5 0.062 13.5 3.7 1.9 2 0 0 2 2 1 0 JNK_SAPK-associated protein-1 bZIP_1 PF00170.21 EDN03195.1 - 0.6 10.2 4.8 0.96 9.6 0.2 2.9 2 1 2 4 4 3 0 bZIP transcription factor TMF_TATA_bd PF12325.8 EDN03195.1 - 0.61 10.3 9.4 2.8 8.2 1.2 2.7 2 1 1 3 3 2 0 TATA element modulatory factor 1 TATA binding Laminin_II PF06009.12 EDN03195.1 - 0.62 10.1 4.3 6 6.9 1.3 2.5 1 1 1 2 2 2 0 Laminin Domain II HIP1_clath_bdg PF16515.5 EDN03195.1 - 0.82 10.3 10.5 3.9 8.1 2.3 3.4 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 EDN03195.1 - 0.9 10.2 6.9 0.78 10.4 2.6 2.8 2 1 2 4 4 3 0 Initiation control protein YabA CCDC154 PF15450.6 EDN03195.1 - 0.96 7.9 11.2 0.49 8.9 7.4 2.0 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 154 Bacillus_HBL PF05791.11 EDN03195.1 - 0.96 9.2 6.4 4.3 7.1 6.3 2.1 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4763 PF15960.5 EDN03195.1 - 0.99 8.7 9.3 2.6 7.3 9.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) DUF1640 PF07798.11 EDN03195.1 - 1.1 9.3 10.4 1 9.4 6.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) PspA_IM30 PF04012.12 EDN03195.1 - 1.6 8.2 5.2 7.3 6.1 4.0 2.3 1 1 1 2 2 2 0 PspA/IM30 family ATG16 PF08614.11 EDN03195.1 - 1.6 8.9 13.3 1.6 8.9 9.4 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CENP-H PF05837.12 EDN03195.1 - 1.9 8.9 8.0 2.1 8.8 5.3 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Tup_N PF08581.10 EDN03195.1 - 2 8.8 5.0 3.7 7.9 2.0 2.6 2 1 1 3 3 2 0 Tup N-terminal ZapB PF06005.12 EDN03195.1 - 2.5 8.6 7.1 0.47 10.9 2.5 2.3 2 1 0 2 2 1 0 Cell division protein ZapB DUF5082 PF16888.5 EDN03195.1 - 2.6 8.3 8.9 1.1 9.5 0.8 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF5082) WXG100 PF06013.12 EDN03195.1 - 3 8.2 6.5 8.1 6.8 1.4 3.4 2 1 2 4 4 3 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 EDN03195.1 - 3.6 8.1 11.0 3.1 8.3 5.8 2.9 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.8 EDN03195.1 - 4.1 7.5 6.7 0.47 10.5 2.0 1.8 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding Syntaxin_2 PF14523.6 EDN03195.1 - 4.3 7.8 10.6 0.81 10.1 6.0 2.2 2 1 0 2 2 1 0 Syntaxin-like protein TPR_MLP1_2 PF07926.12 EDN03195.1 - 4.7 7.3 9.8 0.27 11.3 2.9 2.5 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein V-SNARE PF05008.15 EDN03195.1 - 4.8 7.6 7.5 3.4 8.1 2.9 2.7 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Fib_alpha PF08702.10 EDN03195.1 - 4.9 7.3 12.2 1.8 8.7 6.1 2.9 2 1 2 4 4 3 0 Fibrinogen alpha/beta chain family Anophelin PF10731.9 EDN03196.1 - 0.098 12.5 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito DENN PF02141.21 EDN03197.1 - 4.5e-40 137.6 0.1 1e-39 136.4 0.1 1.6 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EDN03197.1 - 1.2e-06 29.1 0.1 6.9e-06 26.7 0.0 2.4 2 0 0 2 2 2 1 uDENN domain Glyco_hydro_108 PF05838.12 EDN03197.1 - 0.079 13.5 0.0 0.82 10.2 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase 108 zf-HIT PF04438.16 EDN03198.1 - 5.3e-10 39.0 10.3 8.8e-10 38.3 10.3 1.4 1 0 0 1 1 1 1 HIT zinc finger adh_short PF00106.25 EDN03199.1 - 1.6e-22 79.9 0.0 2e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03199.1 - 2.8e-19 69.6 0.0 3.4e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN03199.1 - 9.2e-07 28.9 0.0 1.2e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 KR domain RabGAP-TBC PF00566.18 EDN03200.1 - 4.5e-45 153.9 0.0 3.4e-44 151.1 0.0 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Death PF00531.22 EDN03200.1 - 0.24 11.6 1.0 1.9 8.7 0.1 2.7 3 0 0 3 3 3 0 Death domain Ank_2 PF12796.7 EDN03201.1 - 1.7e-18 67.0 0.0 6e-09 36.4 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN03201.1 - 3.6e-18 65.7 0.0 2.8e-08 34.1 0.0 4.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN03201.1 - 1.9e-14 52.3 0.2 0.013 15.9 0.0 5.2 4 1 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 EDN03201.1 - 2.7e-14 52.9 0.4 0.0051 17.2 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EDN03201.1 - 3.7e-10 39.8 0.0 2.5e-05 24.4 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) F-box-like PF12937.7 EDN03201.1 - 5.1e-07 29.5 0.2 1.2e-06 28.3 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN03201.1 - 0.19 11.7 2.2 1.5 8.8 2.2 2.3 1 1 0 1 1 1 0 F-box domain PKcGMP_CC PF16808.5 EDN03202.1 - 0.19 11.6 4.9 0.34 10.8 3.0 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TMF_TATA_bd PF12325.8 EDN03202.1 - 0.3 11.3 6.8 3 8.1 0.1 2.8 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 EDN03202.1 - 2.4 8.3 7.1 6.5 6.9 0.1 2.9 3 0 0 3 3 3 0 bZIP transcription factor FA_desaturase PF00487.24 EDN03203.1 - 1.1e-13 51.7 24.7 1.1e-13 51.7 24.7 1.8 1 1 1 2 2 2 1 Fatty acid desaturase HEAT PF02985.22 EDN03204.1 - 4.6e-10 38.9 4.1 0.39 11.1 0.0 6.2 6 0 0 6 6 6 3 HEAT repeat WD40 PF00400.32 EDN03204.1 - 2.2e-09 37.8 15.9 2.3e-06 28.2 0.2 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat HEAT_EZ PF13513.6 EDN03204.1 - 7e-05 23.2 0.6 0.0063 17.0 0.2 3.5 3 0 0 3 3 3 1 HEAT-like repeat Ge1_WD40 PF16529.5 EDN03204.1 - 7.3e-05 21.9 0.1 0.011 14.7 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein HEAT_2 PF13646.6 EDN03204.1 - 0.0005 20.4 0.4 8.5 6.9 0.0 4.0 3 1 1 4 4 4 3 HEAT repeats Tti2 PF10521.9 EDN03204.1 - 0.072 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Tti2 family Troponin-I_N PF11636.8 EDN03205.1 - 1.7 8.6 4.2 8.4 6.4 1.4 2.5 2 0 0 2 2 2 0 Troponin I residues 1-32 NUDIX PF00293.28 EDN03208.1 - 3.8e-16 59.3 0.0 6.7e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF202 PF02656.15 EDN03209.1 - 3.9e-12 46.4 2.1 2e-11 44.1 2.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF202) MatE PF01554.18 EDN03210.1 - 1.1e-15 57.7 9.1 9.9e-12 44.8 1.3 2.5 2 1 1 3 3 3 2 MatE Polysacc_synt_C PF14667.6 EDN03210.1 - 0.0098 16.0 5.4 0.0098 16.0 5.4 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis C-terminal domain DnaJ PF00226.31 EDN03211.1 - 1.8e-14 53.6 3.3 4.6e-14 52.3 0.3 3.0 3 0 0 3 3 3 1 DnaJ domain VIR_N PF15912.5 EDN03211.1 - 0.15 11.6 5.0 0.2 11.2 5.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal DEAD PF00270.29 EDN03212.1 - 1.6e-46 158.3 0.3 3.5e-46 157.2 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN03212.1 - 5.6e-24 84.6 0.0 5e-23 81.6 0.0 2.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDN03212.1 - 3.4e-14 52.8 0.0 8.3e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDN03212.1 - 5.8e-09 36.2 0.0 1.8e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDN03212.1 - 0.026 13.7 0.0 0.056 12.6 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DDE_Tnp_1_7 PF13843.6 EDN03213.1 - 2.4e-07 30.4 0.3 2.8e-07 30.2 0.3 1.2 1 0 0 1 1 1 1 Transposase IS4 Toxin_YhaV PF11663.8 EDN03213.1 - 0.098 12.7 0.3 0.13 12.3 0.3 1.2 1 0 0 1 1 1 0 Toxin with endonuclease activity, of toxin-antitoxin system Mur_ligase_C PF02875.21 EDN03213.1 - 0.18 12.1 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain DDE_1 PF03184.19 EDN03214.1 - 4e-31 108.0 0.0 8.8e-31 106.9 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN03214.1 - 7.6e-11 41.9 0.0 2.1e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN03214.1 - 3.4e-07 29.9 0.1 9.4e-07 28.5 0.1 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN03214.1 - 0.00011 22.0 0.1 0.005 16.6 0.0 2.6 2 0 0 2 2 2 1 DDE superfamily endonuclease AA_permease PF00324.21 EDN03216.1 - 1.2e-125 419.9 42.1 1.4e-125 419.6 42.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDN03216.1 - 4.3e-38 131.3 47.8 5.4e-38 130.9 47.8 1.1 1 0 0 1 1 1 1 Amino acid permease PrgI PF12666.7 EDN03216.1 - 0.014 16.1 1.8 0.014 16.1 1.8 4.0 5 0 0 5 5 5 0 PrgI family protein Zn_clus PF00172.18 EDN03218.1 - 9e-05 22.5 12.0 0.00013 22.0 12.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.29 EDN03219.1 - 4.4e-48 163.3 0.1 1.7e-47 161.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN03219.1 - 2.6e-24 85.7 0.2 1.4e-22 80.2 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EDN03219.1 - 3e-22 78.6 1.5 3e-22 78.6 1.5 2.7 3 0 0 3 3 3 1 DBP10CT (NUC160) domain tRNA_anti-codon PF01336.25 EDN03220.1 - 2.1e-06 27.6 0.0 4.3e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.11 EDN03220.1 - 0.00012 22.7 0.0 0.00035 21.2 0.0 1.8 1 0 0 1 1 1 1 Replication protein A C terminal PAPS_reduct PF01507.19 EDN03221.1 - 3.2e-20 72.9 0.5 3.8e-14 53.1 0.1 2.3 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family PAPS_reduct PF01507.19 EDN03222.1 - 1.4e-19 70.8 0.0 1.5e-17 64.2 0.0 2.5 2 1 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family Kdo PF06293.14 EDN03222.1 - 0.0014 18.1 0.1 0.0023 17.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 EDN03223.1 - 5.4e-10 38.9 0.1 2.5e-08 33.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_1 PF00667.20 EDN03224.1 - 4.3e-65 219.4 0.0 6.4e-65 218.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EDN03224.1 - 1.9e-33 115.7 0.8 3.2e-33 115.0 0.8 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EDN03224.1 - 1.6e-20 73.7 0.0 9.4e-20 71.3 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain APH PF01636.23 EDN03226.1 - 0.00024 21.1 0.0 0.0065 16.4 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family MOR2-PAG1_N PF14222.6 EDN03227.1 - 5.9e-139 464.5 0.0 1.3e-89 301.7 0.0 2.3 1 1 1 2 2 2 2 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EDN03227.1 - 1.2e-89 300.6 0.1 3.9e-89 298.8 0.0 2.0 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EDN03227.1 - 5.2e-38 130.4 8.7 2.4e-19 68.6 0.2 4.0 2 1 1 3 3 3 3 Cell morphogenesis central region HET PF06985.11 EDN03228.1 - 6.9e-23 81.6 0.0 1.6e-22 80.5 0.0 1.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Cofac_haem_bdg PF04187.13 EDN03228.1 - 0.19 11.7 0.0 1.1 9.2 0.1 1.9 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN NAD_binding_11 PF14833.6 EDN03229.1 - 4.2e-29 101.3 0.0 6e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EDN03229.1 - 8e-26 91.1 0.0 1.2e-25 90.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh PF00984.19 EDN03229.1 - 0.02 15.1 0.0 0.074 13.3 0.0 1.9 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain MMS1_N PF10433.9 EDN03230.1 - 3.5e-112 375.5 0.0 1.5e-92 310.8 0.0 2.2 2 0 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EDN03230.1 - 4.3e-78 262.9 0.0 3.4e-77 259.9 0.0 2.5 3 0 0 3 3 3 1 CPSF A subunit region PGA2 PF07543.12 EDN03231.1 - 3.4e-48 163.1 0.2 4e-48 162.9 0.2 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 DUF1043 PF06295.12 EDN03231.1 - 0.03 14.3 0.1 1.8 8.6 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) CENP-S PF15630.6 EDN03232.1 - 1e-29 102.7 0.0 1.3e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDN03232.1 - 1.9e-10 40.8 0.0 2.2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EDN03232.1 - 0.001 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated DUF5368 PF17336.2 EDN03233.1 - 0.68 10.1 6.8 1.1 9.5 6.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5368) DUF2235 PF09994.9 EDN03235.1 - 9.8e-98 327.0 0.2 1.3e-97 326.6 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) An_peroxidase PF03098.15 EDN03236.1 - 4.8e-39 134.3 0.1 1.7e-31 109.5 0.0 3.2 1 1 1 2 2 2 2 Animal haem peroxidase TPR_12 PF13424.6 EDN03236.1 - 5.5e-15 55.4 0.1 5.4e-09 36.2 0.0 4.3 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDN03236.1 - 7.1e-13 48.0 0.0 2.1e-05 24.2 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDN03236.1 - 0.0031 17.3 0.8 4.8 7.2 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN03236.1 - 0.0038 16.7 0.1 0.0063 15.9 0.1 1.2 1 0 0 1 1 1 1 MalT-like TPR region TPR_2 PF07719.17 EDN03236.1 - 0.0083 16.2 0.5 3.8 7.8 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN03236.1 - 0.022 14.9 1.8 31 5.1 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN03236.1 - 0.064 14.1 0.0 16 6.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDN03236.1 - 0.077 13.1 0.1 13 6.1 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDN03236.1 - 0.31 11.5 1.2 46 4.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_31 PF01055.26 EDN03237.1 - 8.6e-155 516.2 1.9 1.1e-154 515.9 1.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EDN03237.1 - 3.5e-34 117.5 0.1 6.5e-34 116.6 0.1 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EDN03237.1 - 0.00021 21.5 0.6 0.001 19.3 0.2 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like Hexapep PF00132.24 EDN03238.1 - 1.6e-06 27.6 10.1 5.8e-05 22.7 2.0 4.5 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDN03238.1 - 0.003 17.3 5.9 0.0036 17.0 0.2 2.9 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Rhomboid_SP PF12595.8 EDN03238.1 - 0.22 10.9 0.6 0.37 10.1 0.6 1.4 1 1 0 1 1 1 0 Rhomboid serine protease Arf PF00025.21 EDN03239.1 - 1.7e-29 102.5 0.0 2.1e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDN03239.1 - 0.0061 16.0 0.1 0.0078 15.7 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDN03239.1 - 0.059 12.7 0.1 0.07 12.5 0.1 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AnmK PF03702.14 EDN03239.1 - 0.14 11.2 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase CCDC117 PF15810.5 EDN03240.1 - 0.086 13.1 0.4 0.13 12.6 0.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 SRRM_C PF15230.6 EDN03240.1 - 0.1 13.2 1.1 0.19 12.3 1.1 1.3 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus F-box-like PF12937.7 EDN03241.1 - 0.0032 17.3 0.5 0.016 15.1 0.5 2.1 1 1 0 1 1 1 1 F-box-like MFS_1 PF07690.16 EDN03242.1 - 1.9e-17 63.2 8.4 2.5e-17 62.8 8.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN03242.1 - 2.1e-05 23.6 0.1 2.1e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter VIT1 PF01988.19 EDN03242.1 - 0.78 9.6 3.5 1.1 9.0 3.5 1.4 1 1 0 1 1 1 0 VIT family MCM PF00493.23 EDN03243.1 - 7e-101 336.0 0.0 1.1e-100 335.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDN03243.1 - 1.8e-38 131.2 0.1 3.2e-38 130.4 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EDN03243.1 - 2.3e-35 122.1 30.2 2.3e-35 122.1 30.2 2.9 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EDN03243.1 - 2.8e-24 85.3 0.7 8e-24 83.9 0.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDN03243.1 - 1.7e-14 54.3 0.1 5.7e-14 52.6 0.1 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDN03243.1 - 1.9e-08 34.0 0.1 3.9e-06 26.4 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDN03243.1 - 1.2e-05 25.3 0.1 8.6e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDN03243.1 - 0.00022 21.1 0.0 0.0016 18.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDN03243.1 - 0.0032 17.2 0.2 0.035 13.8 0.2 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 EDN03243.1 - 0.065 12.9 0.3 0.13 12.0 0.3 1.4 1 0 0 1 1 1 0 AAA domain zf-TFIIB PF13453.6 EDN03243.1 - 0.13 11.6 1.5 0.26 10.6 1.5 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger AAA_16 PF13191.6 EDN03243.1 - 0.69 10.3 2.8 0.83 10.0 0.0 2.6 4 0 0 4 4 4 0 AAA ATPase domain TAF4 PF05236.14 EDN03244.1 - 0.1 12.3 1.2 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Pkinase PF00069.25 EDN03245.1 - 2.4e-29 102.5 0.0 2.8e-26 92.5 0.0 2.6 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03245.1 - 6.1e-12 45.4 0.0 7.5e-11 41.8 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN03245.1 - 0.031 13.2 0.0 0.042 12.8 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain DUF1688 PF07958.11 EDN03246.1 - 1.7e-133 445.4 0.0 2.1e-133 445.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Sugar_tr PF00083.24 EDN03247.1 - 1.5e-83 281.2 15.3 1.9e-83 280.8 15.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN03247.1 - 3.6e-27 95.2 68.6 3.2e-24 85.5 36.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDN03247.1 - 0.00036 19.1 3.2 0.00036 19.1 3.2 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDN03247.1 - 1.3 7.2 10.8 0.021 13.1 2.2 2.4 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family EamA PF00892.20 EDN03249.1 - 1.3e-05 25.4 10.7 1.3e-05 25.4 10.7 2.3 2 0 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 EDN03249.1 - 8.7e-05 22.0 15.8 0.00091 18.7 15.8 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family MIS13 PF08202.11 EDN03250.1 - 3.4e-26 92.2 4.7 1.7e-12 47.2 0.3 2.6 1 1 1 2 2 2 2 Mis12-Mtw1 protein family TSC22 PF01166.18 EDN03250.1 - 0.052 13.9 0.1 0.14 12.5 0.1 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DivIC PF04977.15 EDN03250.1 - 0.094 12.5 0.1 0.22 11.3 0.1 1.6 1 0 0 1 1 1 0 Septum formation initiator SNAPc19 PF15497.6 EDN03250.1 - 0.67 10.4 4.7 0.69 10.4 1.3 2.5 2 0 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 PS_Dcarbxylase PF02666.15 EDN03251.1 - 1.1e-55 188.3 0.0 1.6e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EDN03251.1 - 3.5e-38 130.0 0.0 1.4e-17 63.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain EF-hand_1 PF00036.32 EDN03251.1 - 0.007 15.8 0.0 0.025 14.1 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EDN03251.1 - 0.025 14.1 0.0 0.075 12.6 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EDN03251.1 - 0.032 14.1 0.0 0.16 12.0 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain ERp29 PF07749.12 EDN03251.1 - 0.7 10.8 2.1 13 6.8 2.2 2.8 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Ank_2 PF12796.7 EDN03252.1 - 4.3e-18 65.7 0.1 4.7e-08 33.5 0.0 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN03252.1 - 1.1e-12 48.2 0.0 1.9e-08 34.7 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN03252.1 - 2.2e-12 46.8 0.0 2.5e-05 24.5 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EDN03252.1 - 2.4e-11 42.8 0.0 0.012 16.0 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EDN03252.1 - 2.5e-10 40.4 0.1 0.00022 21.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF2288 PF10052.9 EDN03252.1 - 0.28 11.3 0.9 1.5 9.0 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2288) Ank_4 PF13637.6 EDN03254.1 - 1.7e-10 41.2 1.0 1.1e-06 29.1 0.1 3.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDN03254.1 - 4.4e-10 40.0 0.6 4.7e-06 27.1 0.0 3.0 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN03254.1 - 5.4e-09 36.1 0.3 3.1e-07 30.5 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN03254.1 - 2.9e-08 33.3 0.2 7.8e-06 25.9 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EDN03254.1 - 5.1e-08 33.0 1.8 1.2e-06 28.7 0.2 3.4 3 0 0 3 3 3 1 Ankyrin repeat KilA-N PF04383.13 EDN03254.1 - 0.00011 22.0 0.1 0.00078 19.3 0.1 2.4 1 1 0 1 1 1 1 KilA-N domain GCS PF03074.16 EDN03256.1 - 3.3e-175 582.7 0.0 4.1e-175 582.4 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase VIT PF08487.10 EDN03259.1 - 5.7e-33 113.5 0.1 1.2e-32 112.4 0.1 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 EDN03259.1 - 1.4e-22 79.4 0.0 3.9e-22 77.9 0.0 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EDN03259.1 - 2.9e-15 56.6 0.0 6.2e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EDN03259.1 - 1.1e-06 29.2 0.0 3.6e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EDN03259.1 - 0.00016 22.0 0.0 0.00033 21.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain CobT_C PF11775.8 EDN03259.1 - 0.0082 15.8 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT VWA domain GATA PF00320.27 EDN03260.1 - 3.5e-15 55.3 5.3 6.8e-15 54.4 5.3 1.5 1 0 0 1 1 1 1 GATA zinc finger Serine_rich PF08824.10 EDN03260.1 - 0.011 15.7 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Serine rich protein interaction domain zinc_ribbon_9 PF14369.6 EDN03260.1 - 0.47 10.8 1.6 1 9.7 1.6 1.5 1 0 0 1 1 1 0 zinc-ribbon Acetyltransf_4 PF13420.7 EDN03263.1 - 0.0002 21.5 0.0 0.00091 19.4 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN03263.1 - 0.0016 18.8 0.0 0.0024 18.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN03263.1 - 0.0074 16.5 0.0 0.0095 16.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family HGTP_anticodon PF03129.20 EDN03263.1 - 0.13 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Anticodon binding domain Macro PF01661.21 EDN03264.1 - 8.1e-41 138.8 0.1 1.2e-40 138.3 0.1 1.2 1 0 0 1 1 1 1 Macro domain GLTP PF08718.11 EDN03267.1 - 4.5e-39 134.1 0.0 6.6e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) E1-E2_ATPase PF00122.20 EDN03268.1 - 4.9e-19 68.5 0.0 1.1e-18 67.4 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EDN03268.1 - 0.0053 17.1 3.3 1.1 9.4 0.8 2.4 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDN03268.1 - 0.037 13.8 0.1 0.081 12.6 0.1 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDN03268.1 - 0.16 11.4 0.5 0.56 9.7 0.0 1.9 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Ank_2 PF12796.7 EDN03269.1 - 7.9e-23 80.9 4.4 2.9e-10 40.6 2.8 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN03269.1 - 1e-18 67.4 2.0 2.4e-07 31.2 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN03269.1 - 3.8e-15 54.5 0.7 0.00066 19.9 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EDN03269.1 - 8.9e-14 51.4 3.7 2.6e-06 27.6 0.1 4.8 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EDN03269.1 - 1.5e-13 50.6 8.1 0.00076 19.8 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Rbsn PF11464.8 EDN03270.1 - 1.9e-16 59.5 1.0 5.6e-16 58.0 1.0 1.9 1 0 0 1 1 1 1 Rabenosyn Rab binding domain FYVE PF01363.21 EDN03270.1 - 6e-06 26.3 11.5 9.7e-06 25.6 9.8 2.0 2 0 0 2 2 2 1 FYVE zinc finger zf-AN1 PF01428.16 EDN03270.1 - 0.0002 21.5 3.7 0.0002 21.5 3.7 2.0 3 0 0 3 3 2 1 AN1-like Zinc finger zf-Di19 PF05605.12 EDN03270.1 - 0.038 14.3 0.0 0.038 14.3 0.0 2.5 2 1 1 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding YqaH PF17448.2 EDN03270.1 - 0.09 13.1 0.1 0.83 10.0 0.2 2.5 2 1 1 3 3 3 0 Uncharacterized YqaH-like zf-C2HC5 PF06221.13 EDN03270.1 - 0.12 12.4 1.8 0.88 9.6 0.4 2.4 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-ribbon_3 PF13248.6 EDN03270.1 - 0.14 11.6 1.0 1.2 8.7 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain APC_N_CC PF16689.5 EDN03270.1 - 0.17 11.9 1.0 0.64 10.1 0.3 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain zf-C2H2_4 PF13894.6 EDN03270.1 - 0.26 12.2 11.6 1.3 10.0 0.0 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger TMF_TATA_bd PF12325.8 EDN03270.1 - 0.3 11.3 8.3 0.079 13.2 1.2 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding IBR PF01485.21 EDN03270.1 - 2.9 8.2 10.7 0.089 13.0 2.7 2.5 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain PKD_channel PF08016.12 EDN03271.1 - 2.6e-06 26.4 18.3 6.3e-05 21.8 18.1 2.2 1 1 0 1 1 1 1 Polycystin cation channel EIF_2_alpha PF07541.12 EDN03272.1 - 5.4e-37 126.4 0.0 1.1e-36 125.4 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EDN03272.1 - 2.4e-13 50.2 1.0 5.7e-13 49.0 1.0 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Sulfate_transp PF00916.20 EDN03273.1 - 5.6e-42 143.8 7.9 1.3e-41 142.6 7.9 1.6 1 1 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDN03273.1 - 2.5e-09 36.8 0.0 7.1e-09 35.3 0.0 1.8 1 1 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EDN03273.1 - 0.037 14.4 0.0 0.098 13.0 0.0 1.7 1 0 0 1 1 1 0 STAS domain CENP-L PF13092.6 EDN03274.1 - 1.8e-47 161.6 0.1 2.4e-47 161.2 0.1 1.1 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 COX7a PF02238.15 EDN03275.1 - 0.34 11.3 2.0 0.66 10.4 0.0 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Palm_thioest PF02089.15 EDN03276.1 - 2.6e-66 223.9 0.4 1.6e-64 218.0 0.4 2.0 1 1 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 EDN03276.1 - 0.001 18.5 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_2 PF01674.18 EDN03276.1 - 0.0012 18.4 0.0 0.0028 17.2 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_1 PF00561.20 EDN03276.1 - 0.0075 15.9 0.1 0.021 14.5 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3328 PF11807.8 EDN03277.1 - 5.8e-09 36.0 1.2 8.3e-09 35.5 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) RNase_H2-Ydr279 PF09468.10 EDN03277.1 - 0.095 12.9 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF2875 PF11394.8 EDN03277.1 - 0.13 11.1 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2875) AlaDh_PNT_N PF05222.15 EDN03281.1 - 2.9e-24 85.9 0.0 4.4e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EDN03281.1 - 0.0018 17.6 0.0 0.0048 16.2 0.0 1.6 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain BAR PF03114.18 EDN03282.1 - 1.2e-63 214.9 7.6 1.5e-63 214.7 7.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EDN03282.1 - 2.7e-16 58.9 0.1 5.8e-16 57.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN03282.1 - 2.6e-10 40.0 0.0 5.4e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDN03282.1 - 1.5e-08 34.2 0.1 5.6e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain DUF4430 PF14478.6 EDN03282.1 - 0.11 13.0 0.9 4.9 7.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4430) BAR_3 PF16746.5 EDN03282.1 - 0.24 11.1 8.7 0.73 9.5 8.7 1.8 1 1 0 1 1 1 0 BAR domain of APPL family APG6_N PF17675.1 EDN03282.1 - 0.29 11.7 8.0 4.8 7.7 4.2 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Vps5 PF09325.10 EDN03282.1 - 0.69 9.4 10.4 5.2 6.5 10.4 2.0 1 1 0 1 1 1 0 Vps5 C terminal like TMPIT PF07851.13 EDN03282.1 - 0.7 9.1 8.6 2.9 7.0 0.3 2.1 1 1 1 2 2 2 0 TMPIT-like protein BRE1 PF08647.11 EDN03282.1 - 0.81 9.8 10.7 0.57 10.3 0.3 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Aminotran_5 PF00266.19 EDN03283.1 - 1.6e-94 316.9 0.0 8.1e-94 314.6 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V FAD_binding_4 PF01565.23 EDN03283.1 - 5.1e-18 65.1 0.0 2.3e-17 63.0 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Beta_elim_lyase PF01212.21 EDN03283.1 - 1.1e-05 24.9 0.0 1.8e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase BBE PF08031.12 EDN03283.1 - 2e-05 24.6 0.0 4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like DegT_DnrJ_EryC1 PF01041.17 EDN03283.1 - 0.0023 17.3 0.0 0.006 15.9 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EDN03283.1 - 0.09 11.5 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain IDO PF01231.18 EDN03284.1 - 3.8e-161 536.7 0.0 4.3e-161 536.5 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 EDN03284.1 - 0.0035 16.2 0.0 0.0099 14.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1864) CsbD PF05532.12 EDN03285.1 - 1.8e-07 30.9 8.2 1.8e-07 30.9 8.2 3.2 2 1 1 3 3 3 3 CsbD-like ERG2_Sigma1R PF04622.12 EDN03286.1 - 2.3e-49 167.6 0.0 3.1e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein UEV PF05743.13 EDN03287.1 - 4.5e-37 126.6 0.0 7.8e-37 125.8 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EDN03287.1 - 4.6e-19 68.1 0.2 1.4e-18 66.6 0.0 1.9 2 0 0 2 2 2 1 Vps23 core domain ADIP PF11559.8 EDN03287.1 - 4e-05 23.7 3.2 4e-05 23.7 3.2 1.6 2 0 0 2 2 1 1 Afadin- and alpha -actinin-Binding Perilipin PF03036.16 EDN03287.1 - 0.0075 15.3 2.9 0.011 14.7 2.9 1.2 1 0 0 1 1 1 1 Perilipin family UQ_con PF00179.26 EDN03287.1 - 0.012 15.3 0.1 0.03 14.0 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Snapin_Pallidin PF14712.6 EDN03287.1 - 0.023 15.1 3.4 0.046 14.1 3.4 1.5 1 0 0 1 1 1 0 Snapin/Pallidin ATG16 PF08614.11 EDN03287.1 - 0.027 14.7 0.3 0.027 14.7 0.3 2.4 2 1 0 2 2 1 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 EDN03287.1 - 0.052 14.0 0.2 0.052 14.0 0.2 1.8 2 0 0 2 2 1 0 Cell division protein ZapB DUF4618 PF15397.6 EDN03287.1 - 0.055 12.9 1.0 0.12 11.7 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Prominin PF05478.11 EDN03287.1 - 0.14 10.1 0.8 0.2 9.6 0.8 1.1 1 0 0 1 1 1 0 Prominin GCN5L1 PF06320.13 EDN03287.1 - 0.16 12.1 0.2 1.2 9.3 0.3 2.2 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Spc7 PF08317.11 EDN03287.1 - 0.2 10.5 1.1 0.31 9.9 1.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 EDN03287.1 - 0.22 11.8 0.8 0.41 10.9 0.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding RWD PF05773.22 EDN03287.1 - 0.22 11.8 2.9 0.98 9.7 0.0 2.5 2 0 0 2 2 2 0 RWD domain HAUS-augmin3 PF14932.6 EDN03287.1 - 0.27 10.8 4.1 0.44 10.1 4.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Salt_tol_Pase PF09506.10 EDN03287.1 - 0.29 9.9 3.1 0.54 9.0 3.1 1.4 1 1 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) STE2 PF02116.15 EDN03288.1 - 1.3e-98 329.8 28.1 1.5e-98 329.6 28.1 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR Kdo PF06293.14 EDN03289.1 - 4.9e-08 32.6 0.0 0.0021 17.5 0.0 3.7 4 0 0 4 4 4 3 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN03289.1 - 1.3e-06 28.6 0.0 0.004 17.1 0.0 2.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 EDN03289.1 - 0.016 14.6 0.0 0.11 11.8 0.0 2.1 1 1 0 1 1 1 0 Protein kinase domain RIO1 PF01163.22 EDN03289.1 - 0.017 14.7 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 RIO1 family Clat_adaptor_s PF01217.20 EDN03290.1 - 1.7e-50 170.6 1.7 2e-50 170.4 1.7 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 EDN03290.1 - 0.049 14.4 0.0 0.078 13.7 0.0 1.4 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Maf1 PF09174.10 EDN03291.1 - 8e-43 146.6 0.0 1.4e-42 145.8 0.0 1.3 1 0 0 1 1 1 1 Maf1 regulator Type_III_YscX PF09474.10 EDN03291.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) Snapin_Pallidin PF14712.6 EDN03292.1 - 0.00049 20.5 4.5 0.042 14.3 0.1 2.8 3 0 0 3 3 3 2 Snapin/Pallidin DUF5082 PF16888.5 EDN03292.1 - 0.059 13.7 0.2 0.059 13.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) V_ATPase_I PF01496.19 EDN03292.1 - 0.1 10.5 0.0 0.1 10.5 0.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family KxDL PF10241.9 EDN03292.1 - 0.13 12.5 2.9 0.31 11.3 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein GAS PF13851.6 EDN03292.1 - 0.69 9.2 14.9 0.22 10.9 4.4 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding COPIIcoated_ERV PF07970.12 EDN03293.1 - 1.5e-32 113.2 0.0 2.3e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDN03293.1 - 0.00037 20.8 0.1 0.00064 20.0 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Pkinase PF00069.25 EDN03294.1 - 2.2e-30 105.9 0.2 3.1e-30 105.4 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03294.1 - 7.8e-12 45.0 0.1 1.1e-11 44.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN03294.1 - 0.0022 18.0 0.1 0.066 13.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EDN03294.1 - 0.034 13.7 0.1 0.076 12.6 0.1 1.7 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.14 EDN03294.1 - 0.047 13.0 0.1 0.091 12.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN03294.1 - 0.056 13.0 0.2 0.12 11.9 0.2 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase Slu7 PF11708.8 EDN03296.1 - 5.7e-85 285.3 21.3 5.7e-85 285.3 21.3 2.2 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor YhzD PF14120.6 EDN03296.1 - 0.1 12.7 1.1 3.6 7.8 0.9 3.0 2 0 0 2 2 2 0 YhzD-like protein zf-CCHC_4 PF14392.6 EDN03296.1 - 0.15 11.8 0.6 0.36 10.6 0.6 1.6 1 0 0 1 1 1 0 Zinc knuckle DNA_pol_B_exo1 PF03104.19 EDN03297.1 - 3.3e-08 33.0 0.0 1.1e-07 31.3 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EDN03298.1 - 5.7e-22 78.1 0.0 8.2e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDN03298.1 - 1.4e-15 57.3 0.0 2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 EDN03298.1 - 0.047 12.5 0.0 0.071 12.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Acetyltransf_1 PF00583.25 EDN03299.1 - 0.0067 16.6 0.0 0.009 16.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EDN03299.1 - 0.017 15.2 0.0 0.081 13.0 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN03300.1 - 2.4e-06 27.8 0.0 3.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN03300.1 - 5.9e-05 23.4 0.0 0.0001 22.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDN03300.1 - 0.0019 18.3 0.0 0.0029 17.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDN03300.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN03300.1 - 0.036 14.0 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_15 PF17013.5 EDN03300.1 - 0.038 13.4 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_CG PF14542.6 EDN03300.1 - 0.066 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Ank_2 PF12796.7 EDN03301.1 - 9.5e-34 115.8 0.2 6.6e-07 29.8 0.0 7.2 2 1 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN03301.1 - 1.6e-25 89.1 5.3 1e-05 26.0 0.1 7.9 6 1 2 8 8 8 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN03301.1 - 1.2e-20 73.3 1.7 0.00044 20.5 0.0 7.5 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN03301.1 - 1.3e-16 59.0 2.8 0.28 11.9 0.0 8.9 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 EDN03301.1 - 3.4e-12 46.2 3.3 0.036 14.5 0.0 8.2 9 1 0 9 9 9 2 Ankyrin repeat Helo_like_N PF17111.5 EDN03301.1 - 0.00011 21.6 0.2 0.00019 20.9 0.2 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EDN03301.1 - 0.00057 20.1 1.1 0.0013 18.9 1.1 1.6 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Snf7 PF03357.21 EDN03301.1 - 0.087 12.4 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Snf7 I_LWEQ PF01608.17 EDN03303.1 - 4e-56 189.5 8.6 4e-56 189.5 8.6 6.4 4 2 0 6 6 6 2 I/LWEQ domain ANTH PF07651.16 EDN03303.1 - 6.6e-56 189.3 0.3 6.6e-56 189.3 0.3 4.0 3 2 0 3 3 3 1 ANTH domain COX6A PF02046.15 EDN03308.1 - 3.2e-46 156.4 0.0 3.7e-46 156.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Exo_endo_phos PF03372.23 EDN03309.1 - 0.00024 20.7 0.1 0.0007 19.2 0.1 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EDN03309.1 - 0.00033 20.7 0.1 0.00095 19.2 0.1 1.8 1 0 0 1 1 1 1 GRF zinc finger Med12 PF09497.10 EDN03310.1 - 7.1e-27 93.5 0.1 2.1e-26 92.0 0.1 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 CIA30 PF08547.12 EDN03311.1 - 7e-40 136.7 0.0 2e-26 92.9 0.0 2.1 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) Cation_ATPase_N PF00690.26 EDN03311.1 - 0.075 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus SAICAR_synt PF01259.18 EDN03312.1 - 2.2e-99 332.2 0.0 3.5e-99 331.5 0.0 1.3 1 1 0 1 1 1 1 SAICAR synthetase Abhydrolase_8 PF06259.12 EDN03312.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase ANAPC5 PF12862.7 EDN03313.1 - 1.1e-36 124.8 3.5 2.2e-36 123.8 3.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 EDN03313.1 - 0.0065 16.3 1.5 0.0081 16.0 0.4 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDN03313.1 - 0.12 12.7 0.5 0.3 11.4 0.5 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat SUI1 PF01253.22 EDN03314.1 - 3.1e-28 98.1 3.6 4.1e-28 97.7 3.6 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 GlcNAc-1_reg PF18440.1 EDN03314.1 - 0.082 13.2 0.4 0.13 12.5 0.4 1.3 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain Glyco_hydro_47 PF01532.20 EDN03315.1 - 8e-143 476.6 0.1 1.3e-142 475.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 RVT_1 PF00078.27 EDN03316.1 - 6.8e-16 58.5 0.0 1.1e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN03316.1 - 3.1e-13 49.6 0.0 7.8e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN03316.1 - 5.6e-07 29.3 0.2 1.6e-06 27.8 0.2 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN03316.1 - 2.3 8.4 8.7 1.1 9.5 4.8 2.5 2 0 0 2 2 2 0 Zinc knuckle SSF PF00474.17 EDN03317.1 - 2.2e-05 23.5 24.9 0.0015 17.5 24.9 2.5 1 1 0 1 1 1 1 Sodium:solute symporter family TPPK_C PF12555.8 EDN03317.1 - 0.0093 16.0 4.8 0.036 14.1 0.7 3.3 2 0 0 2 2 2 1 Thiamine pyrophosphokinase C terminal FCH PF00611.23 EDN03318.1 - 6.9e-15 55.1 0.6 4.1e-14 52.6 0.1 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.27 EDN03318.1 - 3.8e-11 43.0 0.0 1.3e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain Atg14 PF10186.9 EDN03318.1 - 2.2 7.3 7.2 3.8 6.5 7.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tropomyosin_1 PF12718.7 EDN03318.1 - 4.8 7.3 8.4 9.8 6.3 5.2 2.0 1 1 1 2 2 2 0 Tropomyosin like Ras PF00071.22 EDN03319.1 - 3.5e-55 186.0 0.0 4e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN03319.1 - 3.1e-21 75.8 0.0 4.5e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN03319.1 - 6.4e-09 35.5 0.0 8e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN03319.1 - 0.0059 16.2 0.0 0.013 15.0 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RRM_1 PF00076.22 EDN03320.1 - 6.4e-10 38.7 0.0 1.6e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Caldesmon PF02029.15 EDN03320.1 - 0.017 13.9 54.7 0.1 11.4 47.4 2.1 2 0 0 2 2 2 0 Caldesmon CMS1 PF14617.6 EDN03321.1 - 1.8e-70 237.1 0.9 2.3e-70 236.8 0.9 1.1 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EDN03321.1 - 0.00024 20.9 0.0 0.0004 20.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF678 PF05077.12 EDN03321.1 - 9.7 6.4 7.4 1.5 9.0 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF678) CENP-T_C PF15511.6 EDN03322.1 - 7.9e-44 148.2 0.2 2e-43 146.9 0.0 1.8 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EDN03322.1 - 3.8e-08 33.6 0.0 6.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EDN03322.1 - 4.7e-06 27.0 0.0 1e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DDE_Tnp_IS66 PF03050.14 EDN03322.1 - 0.0037 16.8 0.1 0.0059 16.1 0.1 1.2 1 0 0 1 1 1 1 Transposase IS66 family CBFD_NFYB_HMF PF00808.23 EDN03322.1 - 0.0073 16.6 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SURF1 PF02104.15 EDN03323.1 - 3.8e-41 141.2 0.0 5.1e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 SURF1 family UBX PF00789.20 EDN03324.1 - 1.4e-12 47.6 0.0 2.8e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain Cytadhesin_P30 PF07271.11 EDN03324.1 - 0.012 15.2 1.0 0.029 13.9 1.0 1.6 1 0 0 1 1 1 0 Cytadhesin P30/P32 GREB1 PF15782.5 EDN03324.1 - 5.8 3.9 7.7 7.3 3.6 7.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2076 PF09849.9 EDN03325.1 - 1.6e-07 31.6 13.6 1.9e-07 31.4 13.6 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EDN03325.1 - 0.0025 17.9 0.4 0.004 17.3 0.4 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EDN03325.1 - 0.04 13.9 0.1 0.063 13.3 0.1 1.2 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3275 PF11679.8 EDN03325.1 - 7.8 6.4 9.8 1.1 9.2 4.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) Sas10_Utp3 PF04000.15 EDN03326.1 - 2.8e-18 66.3 0.1 2.8e-18 66.3 0.1 2.3 3 0 0 3 3 3 1 Sas10/Utp3/C1D family LMBR1 PF04791.16 EDN03326.1 - 3.2 6.5 5.0 3.8 6.3 5.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein ApbA PF02558.16 EDN03327.1 - 1.4e-06 28.1 0.0 1.7e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EDN03327.1 - 0.12 13.0 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Exonuc_V_gamma PF04257.14 EDN03327.1 - 0.14 10.3 0.0 0.14 10.3 0.0 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit DUF5633 PF18656.1 EDN03327.1 - 0.21 11.5 0.7 0.35 10.8 0.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5633) LIP PF03583.14 EDN03329.1 - 5.5e-59 199.8 0.0 1.2e-58 198.7 0.0 1.5 1 1 0 1 1 1 1 Secretory lipase Sec2p PF06428.11 EDN03330.1 - 2.8e-28 97.7 16.3 2.8e-28 97.7 16.3 2.2 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p zf-AD PF07776.15 EDN03330.1 - 0.048 13.9 0.0 3.4 8.0 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) GCN5L1 PF06320.13 EDN03330.1 - 0.57 10.4 13.0 1.1 9.4 9.4 2.6 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) MTBP_C PF14920.6 EDN03330.1 - 5.4 6.7 10.5 0.18 11.5 2.7 2.2 1 1 2 3 3 3 0 MDM2-binding PRP21_like_P PF12230.8 EDN03331.1 - 4.4e-46 157.5 14.5 1.9e-45 155.4 14.5 1.8 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EDN03331.1 - 8.5e-40 134.5 4.3 1.1e-20 73.4 0.0 2.9 3 0 0 3 3 3 2 Surp module BBP1_C PF15272.6 EDN03331.1 - 0.02 14.7 4.5 0.044 13.6 4.5 1.5 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal zf_UBZ PF18439.1 EDN03331.1 - 0.094 12.3 0.5 0.22 11.1 0.5 1.7 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger UPF0547 PF10571.9 EDN03331.1 - 0.21 11.7 0.6 0.4 10.8 0.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Ax_dynein_light PF10211.9 EDN03331.1 - 2.9 7.8 11.4 0.025 14.6 2.9 1.7 2 0 0 2 2 2 0 Axonemal dynein light chain PBP_sp32 PF07222.12 EDN03331.1 - 5.4 6.4 8.2 0.77 9.2 2.8 2.0 2 0 0 2 2 2 0 Proacrosin binding protein sp32 PMT PF02366.18 EDN03332.1 - 3.1e-83 279.1 17.9 3.1e-83 279.1 17.9 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.19 EDN03332.1 - 8.3e-45 152.9 0.0 1.9e-44 151.8 0.0 1.5 1 0 0 1 1 1 1 MIR domain PMT_4TMC PF16192.5 EDN03332.1 - 3.9e-33 114.7 5.0 3.9e-33 114.7 5.0 2.4 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase B12D PF06522.11 EDN03333.1 - 0.18 11.6 0.6 0.54 10.1 0.6 1.8 1 1 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DHHC PF01529.20 EDN03334.1 - 4.8e-34 117.3 7.4 7.8e-34 116.7 7.4 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase AWS PF17907.1 EDN03335.1 - 3.9e-07 30.0 6.7 3.9e-07 30.0 6.7 2.0 3 0 0 3 3 3 1 AWS domain SET PF00856.28 EDN03335.1 - 0.13 12.6 0.0 0.13 12.6 0.0 3.7 3 2 1 4 4 4 0 SET domain Fungal_trans PF04082.18 EDN03336.1 - 2.7e-24 85.6 0.0 4.2e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FGGY_C PF02782.16 EDN03337.1 - 1.2e-71 240.5 0.7 2.1e-71 239.8 0.7 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDN03337.1 - 3.8e-25 88.9 0.4 4.9e-24 85.2 0.1 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain MIP PF00230.20 EDN03338.1 - 1.8e-30 106.4 2.1 2.8e-28 99.2 0.0 2.2 1 1 1 2 2 2 2 Major intrinsic protein NDC10_II PF16787.5 EDN03339.1 - 0.059 12.4 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Pkinase PF00069.25 EDN03340.1 - 1.1e-44 152.7 0.3 5.1e-44 150.6 0.3 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03340.1 - 1.1e-30 106.9 0.0 2.1e-30 105.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN03340.1 - 2.8e-06 26.9 0.0 4.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDN03340.1 - 0.0018 17.7 0.0 0.0034 16.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN03340.1 - 0.22 10.3 4.1 0.26 10.0 0.0 2.7 3 0 0 3 3 3 0 Fungal protein kinase DAO PF01266.24 EDN03342.1 - 7.7e-50 170.4 0.0 1.1e-49 169.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EDN03342.1 - 1.4e-16 60.5 0.0 2.7e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EDN03342.1 - 3.8e-09 36.1 0.9 1e-08 34.7 0.9 1.7 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EDN03342.1 - 3e-05 23.6 0.7 0.00091 18.7 0.5 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN03342.1 - 0.00039 19.7 0.2 0.00072 18.9 0.2 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDN03342.1 - 0.0015 17.9 0.2 0.036 13.3 0.1 2.6 1 1 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 EDN03342.1 - 0.0018 18.2 0.1 0.0046 16.9 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EDN03342.1 - 0.0034 17.6 0.2 0.013 15.7 0.2 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EDN03342.1 - 0.0089 15.2 0.1 0.041 13.0 0.1 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EDN03342.1 - 0.021 13.6 0.1 0.035 12.8 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 EDN03342.1 - 0.078 12.2 0.0 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN03342.1 - 0.16 12.5 0.1 0.41 11.2 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1263 PF06882.12 EDN03342.1 - 0.27 11.3 1.8 6.6 6.9 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1263) HDPD PF02924.14 EDN03343.1 - 0.01 15.9 0.1 0.021 14.9 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage lambda head decoration protein D DUF2749 PF10907.8 EDN03344.1 - 1.3 9.3 3.7 2 8.6 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) MFS_1 PF07690.16 EDN03346.1 - 0.11 11.4 15.1 0.019 13.9 6.1 2.4 2 0 0 2 2 2 0 Major Facilitator Superfamily ATP-sulfurylase PF01747.17 EDN03347.1 - 1.1e-85 286.5 0.0 1.5e-85 286.0 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EDN03347.1 - 1.8e-57 193.7 0.1 2.7e-57 193.1 0.1 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EDN03347.1 - 1.6e-53 180.6 0.0 2.7e-53 179.9 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_18 PF13238.6 EDN03347.1 - 0.074 13.6 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain PAS_12 PF18095.1 EDN03348.1 - 0.028 14.1 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain AA_permease_2 PF13520.6 EDN03349.1 - 4.3e-54 184.0 43.3 5.6e-54 183.6 43.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDN03349.1 - 1.4e-26 93.2 36.1 1.9e-26 92.7 36.1 1.0 1 0 0 1 1 1 1 Amino acid permease Phtf-FEM1B_bdg PF12129.8 EDN03349.1 - 1 9.2 11.2 5.1 6.9 0.9 3.6 4 0 0 4 4 4 0 Male germ-cell putative homeodomain transcription factor Glyco_transf_17 PF04724.13 EDN03350.1 - 2e-48 165.3 0.1 3.5e-47 161.1 0.1 2.7 1 1 0 1 1 1 1 Glycosyltransferase family 17 PAPS_reduct PF01507.19 EDN03351.1 - 1.7e-41 142.1 0.0 2.2e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family LIAS_N PF16881.5 EDN03352.1 - 1.3e-18 67.4 0.2 2.5e-18 66.4 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EDN03352.1 - 2.4e-12 47.5 0.0 3.9e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily DUF1338 PF07063.13 EDN03352.1 - 0.13 11.5 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1338) adh_short PF00106.25 EDN03353.1 - 1.1e-22 80.5 0.0 5.9e-15 55.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03353.1 - 8.3e-16 58.2 0.0 3.6e-09 36.5 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN03353.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 KR domain MPS2 PF17060.5 EDN03355.1 - 0.004 16.5 3.4 0.005 16.2 3.4 1.1 1 0 0 1 1 1 1 Monopolar spindle protein 2 Syntaxin-6_N PF09177.11 EDN03355.1 - 0.071 13.7 4.0 0.13 12.8 4.0 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal FAM76 PF16046.5 EDN03355.1 - 0.13 11.6 2.6 0.16 11.3 2.6 1.2 1 0 0 1 1 1 0 FAM76 protein SlyX PF04102.12 EDN03355.1 - 0.34 11.6 7.4 0.81 10.4 7.4 1.7 1 0 0 1 1 1 0 SlyX DUF5082 PF16888.5 EDN03355.1 - 0.41 10.9 9.1 1.2 9.4 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DivIC PF04977.15 EDN03355.1 - 7.7 6.4 9.6 7.2 6.5 4.7 2.4 1 1 0 2 2 2 0 Septum formation initiator Methyltrn_RNA_3 PF02598.17 EDN03356.1 - 1.5e-53 182.2 0.0 1.7e-53 182.0 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase DeoC PF01791.9 EDN03357.1 - 1.1e-11 44.9 2.9 1.6e-11 44.3 2.9 1.2 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHO_dh PF01180.21 EDN03357.1 - 0.00072 18.9 0.7 0.0011 18.2 0.7 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase fn3_PAP PF17808.1 EDN03357.1 - 0.13 12.3 0.1 0.31 11.2 0.1 1.6 1 1 0 1 1 1 0 Fn3-like domain from Purple Acid Phosphatase GRP PF07172.11 EDN03358.1 - 7.4e-05 23.4 8.0 9.7e-05 23.0 8.0 1.1 1 0 0 1 1 1 1 Glycine rich protein family SelK_SelG PF10961.8 EDN03358.1 - 0.073 13.7 26.5 0.26 11.9 10.5 2.4 1 1 1 2 2 2 0 Selenoprotein SelK_SelG TP_methylase PF00590.20 EDN03359.1 - 1.5e-51 175.4 0.1 8.7e-51 172.9 0.1 1.9 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_C PF14823.6 EDN03359.1 - 6.9e-07 28.8 0.0 1.9e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 EDN03359.1 - 2.3e-05 24.8 0.0 4.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding PCI PF01399.27 EDN03360.1 - 1.8e-21 76.6 0.0 5.5e-21 75.1 0.0 1.8 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 EDN03360.1 - 6.3e-15 55.0 0.4 2.2e-14 53.3 0.4 2.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain FSH1 PF03959.13 EDN03361.1 - 4.9e-58 196.3 0.0 6.7e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EDN03361.1 - 0.0023 18.6 0.1 0.0032 18.1 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 EDN03361.1 - 0.023 14.2 0.0 1.9 7.9 0.0 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase DLH PF01738.18 EDN03361.1 - 0.054 13.0 0.0 11 5.5 0.1 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family Ribosomal_S27e PF01667.17 EDN03363.1 - 4.5e-29 99.9 6.1 5.6e-29 99.6 6.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zf-C2HC5 PF06221.13 EDN03363.1 - 0.36 10.9 6.7 1.9 8.5 4.2 2.3 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type CDP-OH_P_transf PF01066.21 EDN03365.1 - 8.2e-15 55.3 0.1 8.2e-15 55.3 0.1 3.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase GWT1 PF06423.12 EDN03365.1 - 0.063 13.4 6.1 0.65 10.1 1.7 2.7 1 1 1 2 2 2 0 GWT1 Doppel PF11466.8 EDN03365.1 - 0.15 11.7 0.7 1.3 8.7 0.1 2.9 2 0 0 2 2 2 0 Prion-like protein Doppel NIPSNAP PF07978.13 EDN03366.1 - 5.1e-31 106.9 1.2 1.9e-30 105.1 0.2 2.3 3 0 0 3 3 3 1 NIPSNAP Putative_PNPOx PF01243.20 EDN03367.1 - 2.2e-13 50.2 0.0 4.5e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Nexin_C PF08628.12 EDN03370.1 - 0.0037 17.8 0.6 0.0044 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal Sfi1 PF08457.10 EDN03371.1 - 0.017 13.7 0.2 0.023 13.2 0.2 1.1 1 0 0 1 1 1 0 Sfi1 spindle body protein Peptidase_C65 PF10275.9 EDN03372.1 - 1.1e-37 129.8 0.0 3.1e-34 118.5 0.0 2.1 1 1 1 2 2 2 2 Peptidase C65 Otubain PCI PF01399.27 EDN03374.1 - 3e-14 53.4 0.1 6.2e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 PCI domain Cir_N PF10197.9 EDN03375.1 - 5e-13 49.0 14.1 5e-13 49.0 14.1 2.5 2 1 1 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.8 EDN03375.1 - 7.6e-13 49.2 1.7 7.6e-13 49.2 1.7 2.8 1 1 1 2 2 2 1 Pre-mRNA splicing factor Ras PF00071.22 EDN03376.1 - 6.6e-37 126.6 0.0 8.6e-37 126.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN03376.1 - 7e-13 48.9 0.0 1.1e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN03376.1 - 3.3e-05 23.4 0.1 4.8e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RVT_2 PF07727.14 EDN03377.1 - 2.8e-10 40.3 0.2 5.6e-10 39.3 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EDN03377.1 - 9.1e-08 31.9 0.0 2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN03377.1 - 7.9e-05 22.3 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN03377.1 - 0.0001 21.9 0.0 0.00028 20.5 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) CALM_bind PF16025.5 EDN03377.1 - 0.026 15.0 0.4 0.095 13.2 0.4 2.0 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding polyprenyl_synt PF00348.17 EDN03380.1 - 3.1e-56 190.3 0.0 3.9e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EDN03380.1 - 0.012 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Rpn3_C PF08375.11 EDN03381.1 - 2e-27 95.4 0.2 5.8e-27 93.9 0.2 1.8 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EDN03381.1 - 7.1e-20 71.5 0.2 2.8e-19 69.6 0.0 2.1 2 0 0 2 2 2 1 PCI domain SOG2 PF10428.9 EDN03381.1 - 2.5 7.2 11.6 3.2 6.8 11.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DASH_Spc34 PF08657.10 EDN03382.1 - 2.7e-53 181.4 1.5 1.9e-31 109.8 0.3 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 ABC_tran_CTD PF16326.5 EDN03382.1 - 0.025 14.8 4.8 2.8 8.3 0.3 2.6 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF4686 PF15742.5 EDN03382.1 - 0.055 12.6 5.2 0.093 11.8 5.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) DASH_Spc19 PF08287.11 EDN03382.1 - 0.26 11.2 5.9 0.63 9.9 5.8 1.7 1 1 0 1 1 1 0 Spc19 DUF465 PF04325.13 EDN03382.1 - 0.49 10.5 7.1 0.17 12.0 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF465) DUF2730 PF10805.8 EDN03382.1 - 0.74 9.9 2.3 9.7 6.3 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF3287 PF11690.8 EDN03382.1 - 1.4 8.6 4.6 12 5.6 0.6 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) TFIID_20kDa PF03847.13 EDN03384.1 - 1.3e-09 38.4 0.0 1.9e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Glyco_hydro_18 PF00704.28 EDN03385.1 - 5.9e-85 285.7 0.2 6.9e-85 285.5 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EDN03385.1 - 1.7e-13 50.4 0.0 3.6e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 LysM domain CorA PF01544.18 EDN03386.1 - 2.8e-13 49.8 0.1 4.7e-13 49.1 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein NAD_binding_6 PF08030.12 EDN03387.1 - 1.9e-21 76.8 0.0 3.5e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDN03387.1 - 9.7e-21 73.9 0.0 2.7e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EDN03387.1 - 1e-18 67.7 9.2 1e-18 67.7 9.2 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component eIF2A PF08662.11 EDN03388.1 - 1.1e-82 276.6 0.0 6.9e-82 274.0 0.0 2.1 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EDN03388.1 - 0.00072 20.3 1.1 0.39 11.7 0.0 4.5 4 1 1 5 5 5 1 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EDN03388.1 - 0.03 12.9 0.0 0.056 12.0 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 EDN03388.1 - 0.046 13.7 3.1 12 6.0 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Acetyltransf_13 PF13880.6 EDN03391.1 - 4.2e-28 97.1 0.1 1.3e-27 95.5 0.0 1.9 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EDN03391.1 - 5e-15 55.0 0.5 9.9e-15 54.1 0.5 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Gly-zipper_Omp PF13488.6 EDN03392.1 - 0.038 14.0 2.1 0.085 12.9 2.1 1.5 1 0 0 1 1 1 0 Glycine zipper Glyoxalase PF00903.25 EDN03392.1 - 0.07 13.3 0.0 0.07 13.3 0.0 2.3 2 1 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Rick_17kDa_Anti PF05433.15 EDN03392.1 - 0.2 11.5 5.5 0.49 10.3 5.5 1.6 1 0 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.6 EDN03392.1 - 0.39 10.5 8.2 0.93 9.3 8.2 1.6 1 0 0 1 1 1 0 Glycine-zipper domain EMG1 PF03587.14 EDN03394.1 - 9.6e-80 266.8 0.0 1.1e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase UQ_con PF00179.26 EDN03395.1 - 3.3e-52 175.9 0.0 3.6e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN03395.1 - 0.0045 16.7 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDN03395.1 - 0.031 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EDN03395.1 - 0.039 14.3 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain DLIC PF05783.11 EDN03396.1 - 0.12 11.2 0.1 0.16 10.8 0.1 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) XPG_N PF00752.17 EDN03397.1 - 1.4e-30 105.7 0.0 5.1e-30 103.9 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDN03397.1 - 1.5e-30 105.4 2.0 1.6e-30 105.3 0.0 2.0 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 EDN03397.1 - 1.1e-05 26.0 0.4 6.8e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EDN03397.1 - 0.077 13.6 0.0 0.19 12.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain HXXSHH PF07586.11 EDN03397.1 - 0.27 10.8 4.2 0.54 9.8 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) AAA_23 PF13476.6 EDN03397.1 - 1.1 9.8 9.1 0.45 11.0 6.8 1.6 2 0 0 2 2 2 0 AAA domain AMP-binding PF00501.28 EDN03398.1 - 6.4e-70 235.9 0.0 8.6e-70 235.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN03398.1 - 6.1e-13 49.5 2.2 9e-13 49.0 0.1 2.4 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Aminotran_3 PF00202.21 EDN03399.1 - 4.8e-22 78.2 0.0 5.5e-22 78.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III adh_short_C2 PF13561.6 EDN03400.1 - 3e-42 144.8 0.0 3.7e-41 141.2 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN03400.1 - 3.3e-39 134.4 0.0 6.7e-38 130.1 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN03400.1 - 1.9e-09 37.7 0.0 3e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EDN03400.1 - 0.044 13.8 0.1 0.08 12.9 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Polysacc_synt_2 PF02719.15 EDN03400.1 - 0.095 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein LDcluster4 PF18306.1 EDN03400.1 - 0.14 11.7 0.1 0.31 10.6 0.1 1.5 2 0 0 2 2 2 0 SLOG cluster4 family Epimerase PF01370.21 EDN03400.1 - 0.2 11.1 0.0 0.4 10.1 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family MFS_1 PF07690.16 EDN03401.1 - 2.1e-14 53.2 30.6 2.1e-14 53.2 30.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LapA_dom PF06305.11 EDN03401.1 - 7 6.5 11.4 1.7 8.6 1.5 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain GMC_oxred_N PF00732.19 EDN03403.1 - 4.3e-27 95.2 0.0 1.9e-26 93.1 0.1 1.8 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN03403.1 - 3.6e-26 92.4 0.0 8.4e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDN03403.1 - 0.00014 21.1 0.0 0.00027 20.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EDN03403.1 - 0.0031 16.8 0.3 0.051 12.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Linker_histone PF00538.19 EDN03405.1 - 1.4e-26 92.7 0.2 1.4e-26 92.7 0.2 1.6 2 0 0 2 2 2 1 linker histone H1 and H5 family Toxin_trans PF07952.12 EDN03405.1 - 0.016 14.3 0.1 0.021 13.9 0.1 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain Ribosomal_L19e PF01280.20 EDN03405.1 - 1 9.4 8.7 0.14 12.2 0.8 2.1 2 0 0 2 2 2 0 Ribosomal protein L19e PIP5K PF01504.18 EDN03406.1 - 1.1e-101 339.7 0.1 2.4e-101 338.6 0.0 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase PC_rep PF01851.22 EDN03409.1 - 0.13 12.8 0.1 55 4.5 0.1 3.3 2 0 0 2 2 2 0 Proteasome/cyclosome repeat Fungal_trans_2 PF11951.8 EDN03410.1 - 3.4e-17 62.3 0.0 1.6e-13 50.3 0.0 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain HAUS-augmin3 PF14932.6 EDN03410.1 - 0.049 13.2 0.0 0.067 12.8 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Phosphoesterase PF04185.14 EDN03414.1 - 1e-56 192.7 0.3 1e-56 192.7 0.3 1.5 2 0 0 2 2 2 1 Phosphoesterase family Sugar_tr PF00083.24 EDN03415.1 - 9.4e-51 173.1 3.9 1.1e-50 172.8 3.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN03415.1 - 3.6e-13 49.2 1.7 3.6e-13 49.2 1.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Cons_hypoth698 PF03601.14 EDN03415.1 - 0.0032 16.4 2.3 0.004 16.1 2.3 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 698 MFS_MOT1 PF16983.5 EDN03415.1 - 0.017 15.6 3.3 0.032 14.6 3.3 1.6 1 0 0 1 1 1 0 Molybdate transporter of MFS superfamily CaATP_NAI PF12515.8 EDN03415.1 - 0.11 12.1 0.9 0.24 11.1 0.9 1.5 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain HUN PF08729.10 EDN03418.1 - 1.9e-06 27.7 0.0 4.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 HPC2 and ubinuclein domain RPAP1_C PF08620.10 EDN03419.1 - 9.3e-24 83.3 0.1 1.4e-23 82.7 0.1 1.3 1 0 0 1 1 1 1 RPAP1-like, C-terminal PDR_CDR PF06422.12 EDN03420.1 - 0.36 10.8 1.7 1.1 9.2 1.7 1.7 1 0 0 1 1 1 0 CDR ABC transporter ABC2_membrane PF01061.24 EDN03421.1 - 4.2e-35 121.1 22.0 4.2e-35 121.1 22.0 1.8 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.12 EDN03421.1 - 6.7e-24 83.6 0.3 6.7e-24 83.6 0.3 2.7 3 0 0 3 3 2 1 CDR ABC transporter ABC_tran PF00005.27 EDN03421.1 - 1.8e-23 83.6 0.0 3.6e-17 63.2 0.0 3.0 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EDN03421.1 - 5.6e-06 26.4 0.1 0.11 12.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EDN03421.1 - 1.2e-05 24.7 16.8 2.6e-05 23.5 16.7 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_25 PF13481.6 EDN03421.1 - 1.3e-05 24.9 0.1 3.4e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDN03421.1 - 2.9e-05 24.5 0.0 6.9e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EDN03421.1 - 9.3e-05 22.1 0.1 0.0011 18.6 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN03421.1 - 0.00075 19.4 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 EDN03421.1 - 0.00086 19.9 0.0 0.0018 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EDN03421.1 - 0.0016 18.0 0.0 0.48 9.8 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 EDN03421.1 - 0.0062 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EDN03421.1 - 0.011 15.3 0.1 0.021 14.4 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EDN03421.1 - 0.018 15.3 0.1 0.14 12.4 0.1 2.2 1 1 0 1 1 1 0 AAA domain Pax2_C PF12403.8 EDN03421.1 - 0.042 13.9 0.2 0.14 12.2 0.1 1.8 2 0 0 2 2 2 0 Paired-box protein 2 C terminal AAA_23 PF13476.6 EDN03421.1 - 0.05 14.1 1.0 0.076 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDN03421.1 - 0.053 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDN03421.1 - 0.057 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 EDN03421.1 - 0.11 12.8 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain Chs7 PF12271.8 EDN03424.1 - 7.9e-124 412.7 19.9 9e-124 412.5 19.9 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3382 PF11862.8 EDN03424.1 - 0.65 10.3 10.2 0.036 14.3 3.3 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) Abhydrolase_6 PF12697.7 EDN03425.1 - 2.9e-05 24.8 1.1 4.4e-05 24.2 1.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EDN03425.1 - 9.4e-05 22.0 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EDN03425.1 - 0.00085 19.1 0.7 0.0017 18.1 0.8 1.5 1 1 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 EDN03425.1 - 0.0032 16.7 0.0 0.0047 16.1 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EDN03425.1 - 0.0045 16.3 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EDN03425.1 - 0.041 13.4 0.1 0.73 9.3 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_2 PF02230.16 EDN03425.1 - 0.052 13.3 0.1 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 EDN03425.1 - 0.11 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain DUF915 PF06028.11 EDN03425.1 - 0.14 11.5 0.0 11 5.3 0.0 2.9 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) Herpes_capsid PF06112.11 EDN03425.1 - 9 6.3 9.5 18 5.4 9.5 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein YCII PF03795.14 EDN03426.1 - 2.5e-09 37.4 0.0 3.6e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain AMP-binding PF00501.28 EDN03429.1 - 1.3e-33 116.3 0.0 3.9e-33 114.7 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EDN03429.1 - 3.3e-09 36.5 0.8 7.9e-09 35.3 0.8 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus DUF1179 PF06678.11 EDN03429.1 - 0.12 12.3 1.0 0.31 11.1 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1179) DUF4718 PF15842.5 EDN03429.1 - 0.93 9.3 4.0 1.7 8.4 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) SR-25 PF10500.9 EDN03429.1 - 3.9 7.0 9.0 6.2 6.4 9.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_M16 PF00675.20 EDN03430.1 - 2.6e-30 105.4 0.0 3.3e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDN03431.1 - 7.7e-36 123.8 0.0 1e-35 123.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16 inactive domain Abhydrolase_2 PF02230.16 EDN03432.1 - 1.3e-27 97.1 0.0 2.6e-19 69.9 0.0 2.9 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EDN03432.1 - 0.0038 17.9 5.9 0.0066 17.1 5.9 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EDN03432.1 - 0.0047 16.4 0.0 0.0082 15.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EDN03432.1 - 0.0088 15.7 0.0 0.013 15.2 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EDN03432.1 - 0.042 13.7 0.5 0.4 10.5 0.5 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN03432.1 - 0.053 12.8 0.1 1.1 8.5 0.0 2.6 3 0 0 3 3 3 0 Serine aminopeptidase, S33 DLH PF01738.18 EDN03432.1 - 0.14 11.6 0.0 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 Dienelactone hydrolase family Aminotran_1_2 PF00155.21 EDN03433.1 - 5.5e-34 117.9 0.0 7.6e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Tmemb_18A PF09771.9 EDN03433.1 - 0.0023 18.3 0.0 0.0041 17.5 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 188 Aminotran_5 PF00266.19 EDN03433.1 - 0.0076 15.3 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V PQ-loop PF04193.14 EDN03434.1 - 6.9e-21 73.8 6.5 4.4e-18 64.8 1.7 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EDN03434.1 - 0.19 11.8 0.1 0.19 11.8 0.1 2.0 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange SH3_1 PF00018.28 EDN03435.1 - 2.9e-05 23.6 0.1 5.9e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain DUF4780 PF16012.5 EDN03435.1 - 0.16 11.5 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4780) Pkinase PF00069.25 EDN03436.1 - 3.8e-46 157.6 0.0 4.8e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03436.1 - 7.9e-26 90.9 0.0 9.9e-21 74.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN03436.1 - 0.037 12.8 0.0 0.057 12.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EDN03436.1 - 0.086 12.7 0.7 0.49 10.3 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L27A PF00828.19 EDN03437.1 - 9.4e-13 49.0 0.6 1.8e-12 48.1 0.6 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AATase PF07247.12 EDN03439.1 - 1.4e-08 33.8 0.0 2.7e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Alcohol acetyltransferase Pyr_redox_2 PF07992.14 EDN03440.1 - 1.1e-50 172.5 0.0 1.4e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN03440.1 - 6.9e-10 39.3 0.0 6.3e-09 36.3 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN03440.1 - 0.0032 16.8 0.1 2.4 7.3 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EcoR124_C PF12008.8 EDN03440.1 - 0.16 11.6 0.3 0.56 9.8 0.0 1.8 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal DUF4211 PF13926.6 EDN03442.1 - 3.6e-42 143.8 0.0 8.4e-42 142.6 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) DUF4449 PF14613.6 EDN03443.1 - 8.6e-46 156.0 0.4 8.6e-46 156.0 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) PTPLA PF04387.14 EDN03444.1 - 9e-28 97.1 1.8 1.2e-27 96.6 1.8 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA SAMP PF05924.11 EDN03444.1 - 0.2 11.0 0.2 0.39 10.1 0.0 1.6 2 0 0 2 2 2 0 SAMP Motif Adaptin_binding PF10199.9 EDN03445.1 - 1.3e-17 64.5 2.6 1.3e-17 64.5 2.6 1.8 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 DUF1241 PF06840.11 EDN03445.1 - 0.024 14.3 0.1 0.057 13.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1241) LSM PF01423.22 EDN03446.1 - 1.1e-14 53.8 0.3 1.5e-14 53.4 0.3 1.2 1 0 0 1 1 1 1 LSM domain PGP_phosphatase PF09419.10 EDN03447.1 - 1.3e-41 142.0 0.0 2.2e-40 138.0 0.0 2.0 1 1 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EDN03447.1 - 2.9e-05 24.0 0.0 5.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDN03447.1 - 0.02 15.2 0.0 1.8 8.8 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 EDN03448.1 - 8.9e-20 70.3 4.0 2e-19 69.2 4.0 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDN03448.1 - 0.0028 17.5 0.4 0.0028 17.5 0.4 2.1 2 0 0 2 2 2 1 Homeobox KN domain SR-25 PF10500.9 EDN03448.1 - 0.073 12.7 5.5 0.12 11.9 5.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SprA-related PF12118.8 EDN03448.1 - 0.51 9.4 12.8 0.99 8.5 12.8 1.4 1 0 0 1 1 1 0 SprA-related family Tho2 PF11262.8 EDN03448.1 - 0.76 8.9 2.6 1.1 8.4 2.6 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 MFS_1 PF07690.16 EDN03450.1 - 1.6e-35 122.7 13.7 2e-35 122.3 13.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN03450.1 - 1.7e-10 40.4 10.5 5.3e-10 38.7 10.5 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter PhoLip_ATPase_C PF16212.5 EDN03451.1 - 2.5e-73 246.9 21.0 2.5e-73 246.9 21.0 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDN03451.1 - 6.1e-24 83.5 2.1 8.3e-23 79.9 0.2 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EDN03451.1 - 3.9e-14 53.4 0.7 3.1e-05 24.4 0.0 3.5 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDN03451.1 - 2e-11 43.8 0.0 1.2e-10 41.4 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EDN03451.1 - 7.6e-07 28.8 0.4 2.1e-06 27.4 0.4 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDN03451.1 - 0.0015 18.3 0.0 0.0041 16.9 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDN03451.1 - 0.11 12.5 0.1 3 7.9 0.1 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TMEM126 PF07114.11 EDN03451.1 - 0.12 11.8 0.1 0.31 10.4 0.1 1.6 1 0 0 1 1 1 0 Transmembrane protein 126 NAD_binding_10 PF13460.6 EDN03452.1 - 8e-09 35.6 0.0 1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDN03452.1 - 0.00019 21.0 0.0 0.0004 19.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN03452.1 - 0.00066 18.8 0.0 0.00092 18.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EDN03452.1 - 0.0017 18.8 0.0 0.0029 18.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EDN03452.1 - 0.0021 18.2 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 EDN03452.1 - 0.022 14.4 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family NAD_binding_4 PF07993.12 EDN03452.1 - 0.04 13.1 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein RmlD_sub_bind PF04321.17 EDN03452.1 - 0.051 12.7 0.0 0.069 12.2 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain vWA-TerF-like PF10138.9 EDN03453.1 - 0.00057 20.0 0.0 0.00089 19.4 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus SRP_TPR_like PF17004.5 EDN03455.1 - 6.3e-19 68.1 0.2 1.9e-18 66.5 0.1 1.9 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 EDN03455.1 - 3e-16 59.6 11.0 3e-16 59.6 11.0 2.3 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EDN03455.1 - 1.6e-06 28.5 7.2 0.0083 16.6 0.0 4.7 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN03455.1 - 2.6e-06 27.6 3.5 0.028 14.6 0.1 4.4 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EDN03455.1 - 0.00029 21.4 11.3 3.2 8.8 0.0 8.4 8 3 3 11 11 10 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDN03455.1 - 0.0078 16.3 2.8 41 4.6 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDN03455.1 - 0.098 13.3 4.0 1.4e+02 3.2 0.0 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF4810 PF16068.5 EDN03455.1 - 0.14 12.7 0.0 0.57 10.8 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) Dicty_REP PF05086.12 EDN03455.1 - 0.17 9.8 1.9 0.25 9.3 1.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1522 PF07482.11 EDN03455.1 - 0.17 12.2 3.7 16 5.9 1.5 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1522) PPR PF01535.20 EDN03455.1 - 0.27 11.6 0.8 29 5.2 0.0 3.9 4 0 0 4 4 4 0 PPR repeat TPR_4 PF07721.14 EDN03455.1 - 0.78 10.5 4.1 4.9 8.1 0.1 3.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 EDN03455.1 - 1.7 9.0 4.9 2.4 8.6 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat adh_short PF00106.25 EDN03456.1 - 8.3e-13 48.2 0.0 1e-06 28.3 0.2 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03456.1 - 7.2e-07 29.0 0.0 0.031 13.8 0.1 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN03456.1 - 0.036 14.0 0.1 0.93 9.4 0.1 2.1 2 0 0 2 2 2 0 KR domain FAD_binding_1 PF00667.20 EDN03457.1 - 2.7e-17 63.1 0.0 1.7e-10 40.9 0.0 2.2 1 1 1 2 2 2 2 FAD binding domain NAD_binding_1 PF00175.21 EDN03457.1 - 2.6e-09 37.7 0.0 6.1e-09 36.5 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Med20 PF08612.11 EDN03459.1 - 3.5e-93 311.1 0.0 4.4e-93 310.8 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Spt20 PF12090.8 EDN03459.1 - 0.14 11.7 9.1 0.28 10.8 9.1 1.4 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 EDN03459.1 - 0.72 9.8 4.5 1.4 8.9 4.5 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EF-hand_1 PF00036.32 EDN03460.1 - 1.3e-41 137.0 11.6 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDN03460.1 - 3.6e-36 123.4 5.3 3.9e-19 68.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDN03460.1 - 1.9e-34 117.3 11.5 2.4e-15 56.1 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EDN03460.1 - 3.8e-30 101.2 8.5 7.1e-09 34.9 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EDN03460.1 - 6.8e-26 88.6 9.8 4.7e-06 25.9 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EDN03460.1 - 1.4e-16 60.5 0.4 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EDN03460.1 - 6.8e-10 38.8 1.6 0.00078 19.4 0.3 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDN03460.1 - 5.9e-09 36.2 0.2 0.0016 18.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EDN03460.1 - 1e-06 28.6 0.1 0.008 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EDN03460.1 - 6.4e-06 26.2 1.6 2.3e-05 24.4 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EDN03460.1 - 9.4e-05 23.2 0.2 0.0025 18.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EDN03460.1 - 0.00013 21.9 0.3 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EDN03460.1 - 0.00059 19.8 1.6 0.52 10.2 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 EDN03460.1 - 0.00062 20.1 0.7 0.66 10.3 0.1 2.6 2 1 1 3 3 3 2 RNA polymerase Rpb4 Dockerin_1 PF00404.18 EDN03460.1 - 0.0053 16.9 7.0 0.38 11.0 0.8 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 EDN03460.1 - 0.0057 15.3 0.0 0.0058 15.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EDN03460.1 - 0.0084 16.0 0.7 0.32 10.9 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 EDN03460.1 - 0.012 16.0 0.5 6.2 7.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 EDN03460.1 - 0.023 14.9 0.0 0.18 12.0 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein RuvA_C PF07499.13 EDN03460.1 - 0.058 13.9 0.1 8.5 6.9 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain dCache_2 PF08269.11 EDN03460.1 - 0.061 12.5 0.1 1 8.5 0.1 2.1 1 1 1 2 2 2 0 Cache domain MotA_activ PF09114.10 EDN03460.1 - 0.061 13.5 0.3 0.91 9.7 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF4497 PF14924.6 EDN03460.1 - 0.092 13.2 0.0 8.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) RloB PF13707.6 EDN03460.1 - 0.11 12.7 1.3 0.72 10.0 0.2 2.1 1 1 1 2 2 2 0 RloB-like protein DUF5132 PF17195.4 EDN03460.1 - 0.16 12.1 0.5 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) Syntaxin PF00804.25 EDN03461.1 - 5.5e-06 26.2 6.7 9e-06 25.5 6.7 1.3 1 0 0 1 1 1 1 Syntaxin MCPsignal PF00015.21 EDN03461.1 - 0.0071 16.2 7.0 0.055 13.3 0.5 2.3 2 0 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain LUC7 PF03194.15 EDN03461.1 - 0.0092 15.7 2.0 0.017 14.8 2.0 1.4 1 0 0 1 1 1 1 LUC7 N_terminus SNARE PF05739.19 EDN03461.1 - 0.01 15.8 1.5 0.015 15.3 0.3 1.8 2 0 0 2 2 2 0 SNARE domain DNA_repr_REX1B PF14966.6 EDN03461.1 - 0.027 15.1 0.4 0.027 15.1 0.4 2.1 2 1 0 2 2 2 0 DNA repair REX1-B Rrp44_CSD1 PF17216.3 EDN03461.1 - 0.027 14.2 0.2 0.08 12.7 0.2 1.7 1 0 0 1 1 1 0 Rrp44-like cold shock domain MAP65_ASE1 PF03999.12 EDN03461.1 - 0.082 11.6 4.6 0.1 11.3 4.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Syntaxin_2 PF14523.6 EDN03461.1 - 0.68 10.3 7.2 0.29 11.5 3.6 2.1 2 0 0 2 2 2 0 Syntaxin-like protein MutS_III PF05192.18 EDN03461.1 - 1 9.5 5.9 2.1 8.5 5.9 1.6 1 1 0 1 1 1 0 MutS domain III SlyX PF04102.12 EDN03461.1 - 2 9.1 6.9 7.6 7.2 0.1 3.2 3 1 0 3 3 3 0 SlyX CTD_bind PF04818.13 EDN03462.1 - 4.7e-10 40.2 0.2 1.1e-09 39.0 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Clathrin_lg_ch PF01086.17 EDN03463.1 - 4.9e-72 242.7 0.6 5.5e-72 242.6 0.6 1.0 1 0 0 1 1 1 1 Clathrin light chain Acyl_transf_3 PF01757.22 EDN03464.1 - 4.4e-14 52.3 22.5 5.6e-14 51.9 22.5 1.2 1 0 0 1 1 1 1 Acyltransferase family Acyl_transf_3 PF01757.22 EDN03465.1 - 3.2e-22 79.1 45.5 2.3e-13 49.9 5.0 3.0 1 1 1 2 2 2 2 Acyltransferase family RseC_MucC PF04246.12 EDN03465.1 - 3 7.8 5.4 2.8 7.9 1.2 2.8 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Mannosyl_trans3 PF11051.8 EDN03466.1 - 3.8e-58 197.0 0.0 1.6e-36 126.1 0.0 2.1 1 1 1 2 2 2 2 Mannosyltransferase putative CDC37_N PF03234.14 EDN03467.1 - 2.2e-49 167.6 2.6 2.2e-49 167.6 2.6 2.8 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EDN03467.1 - 4.3e-40 136.3 0.4 1.9e-39 134.2 0.0 2.1 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EDN03467.1 - 2.9e-08 33.8 0.1 2.9e-08 33.8 0.1 2.9 3 1 0 3 3 3 1 Cdc37 C terminal domain DUF3552 PF12072.8 EDN03467.1 - 0.0063 16.0 3.1 0.0063 16.0 3.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) MecA_N PF05223.11 EDN03467.1 - 0.072 13.4 2.6 0.14 12.4 0.8 2.2 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain ABC_tran PF00005.27 EDN03468.1 - 8.7e-18 65.2 0.0 2e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDN03468.1 - 0.0012 18.3 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EDN03468.1 - 0.028 14.7 2.9 0.28 11.4 0.8 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.9 EDN03468.1 - 0.059 12.2 0.1 0.079 11.7 0.1 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Nucleoside_tran PF01733.18 EDN03469.1 - 1.5e-31 109.9 18.7 4.2e-24 85.5 2.2 2.7 3 0 0 3 3 3 2 Nucleoside transporter DUF5083 PF16890.5 EDN03469.1 - 0.11 12.3 2.3 0.2 11.4 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5083) Fungal_trans PF04082.18 EDN03470.1 - 3.2e-08 32.9 0.6 5.7e-08 32.1 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1029 PF06269.12 EDN03470.1 - 0.055 13.6 0.2 0.25 11.5 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1029) DUF3927 PF13064.6 EDN03470.1 - 0.084 12.9 0.1 0.25 11.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) Haspin_kinase PF12330.8 EDN03471.1 - 5.1e-38 131.0 0.0 1e-37 129.9 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDN03471.1 - 0.071 13.0 0.1 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family AbiEii PF08843.11 EDN03473.1 - 0.059 13.3 0.0 0.062 13.2 0.0 1.1 1 0 0 1 1 1 0 Nucleotidyl transferase AbiEii toxin, Type IV TA system NTP_transf_8 PF12281.8 EDN03473.1 - 0.083 12.9 0.1 0.2 11.6 0.1 1.6 1 1 0 1 1 1 0 Nucleotidyltransferase DUF1682 PF07946.14 EDN03475.1 - 1.2e-115 386.1 0.1 1.4e-115 385.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF4484 PF14831.6 EDN03475.1 - 0.0031 17.6 0.6 0.0052 16.8 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) COX7a PF02238.15 EDN03476.1 - 8.1e-24 83.8 0.6 1e-23 83.5 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII PPR_2 PF13041.6 EDN03477.1 - 0.001 19.2 0.1 0.0093 16.1 0.0 2.6 3 0 0 3 3 3 1 PPR repeat family PPR_3 PF13812.6 EDN03477.1 - 0.0042 17.1 0.3 0.03 14.4 0.1 2.4 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR PF01535.20 EDN03477.1 - 0.0088 16.2 0.0 31 5.1 0.0 4.2 4 0 0 4 4 4 1 PPR repeat PRP4 PF08799.11 EDN03477.1 - 0.15 11.7 0.2 2.8 7.6 0.0 2.6 2 0 0 2 2 2 0 pre-mRNA processing factor 4 (PRP4) like Ins_P5_2-kin PF06090.12 EDN03478.1 - 7.8e-48 163.6 0.0 2.7e-47 161.8 0.0 1.8 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DDE_1 PF03184.19 EDN03479.1 - 1.6e-19 70.2 0.2 4.8e-19 68.7 0.0 1.9 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN03479.1 - 3.7e-05 23.7 2.1 0.00012 22.0 0.0 2.8 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain PFL-like PF02901.15 EDN03479.1 - 0.019 13.6 2.4 0.022 13.4 1.6 1.5 1 1 0 1 1 1 0 Pyruvate formate lyase-like DDE_3 PF13358.6 EDN03479.1 - 0.078 12.7 0.1 0.34 10.6 0.1 2.1 2 0 0 2 2 2 0 DDE superfamily endonuclease P3A PF08727.11 EDN03479.1 - 0.16 11.4 0.0 13 5.3 0.0 2.4 2 0 0 2 2 2 0 Poliovirus 3A protein like Nitroreductase PF00881.24 EDN03481.1 - 7.2e-17 61.9 0.0 8.8e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family YEATS PF03366.16 EDN03482.1 - 1.3e-36 124.4 1.6 2.4e-36 123.6 1.6 1.4 1 0 0 1 1 1 1 YEATS family M16C_assoc PF08367.11 EDN03482.1 - 0.14 11.3 3.6 0.2 10.8 3.6 1.2 1 0 0 1 1 1 0 Peptidase M16C associated Synaptobrevin PF00957.21 EDN03482.1 - 0.23 11.3 0.5 0.39 10.6 0.5 1.3 1 0 0 1 1 1 0 Synaptobrevin NAD_binding_10 PF13460.6 EDN03483.1 - 1.1e-06 28.6 0.0 1.7e-05 24.8 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDN03483.1 - 7.6e-06 25.6 0.0 1.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN03483.1 - 0.00018 20.7 0.0 0.00099 18.2 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EDN03483.1 - 0.0039 16.7 0.0 0.0075 15.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 EDN03483.1 - 0.0071 15.5 0.0 0.022 13.8 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain KR PF08659.10 EDN03483.1 - 0.051 13.5 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 KR domain SYF2 PF08231.12 EDN03484.1 - 1.9e-41 142.1 19.3 1.9e-41 142.1 19.3 2.7 2 1 0 2 2 2 1 SYF2 splicing factor RhgB_N PF09284.10 EDN03485.1 - 0.089 12.3 0.0 0.18 11.3 0.0 1.4 2 0 0 2 2 2 0 Rhamnogalacturonan lyase B, N-terminal DUF4266 PF14086.6 EDN03486.1 - 0.33 11.9 8.0 0.81 10.7 8.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4266) TPR_14 PF13428.6 EDN03487.1 - 0.14 13.1 5.3 2.4 9.2 0.1 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 EDN03487.1 - 0.24 12.2 3.1 35 5.3 0.0 4.1 5 0 0 5 5 5 0 Sel1 repeat Ribosomal_L12 PF00542.19 EDN03488.1 - 3.4e-20 72.2 4.8 4.8e-19 68.5 4.8 2.2 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EDN03488.1 - 1.4e-06 27.9 1.3 1.4e-06 27.9 1.3 3.8 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EDN03488.1 - 0.0054 17.3 0.6 0.0054 17.3 0.6 2.2 3 0 0 3 3 3 1 60s Acidic ribosomal protein Dermcidin PF15291.6 EDN03488.1 - 0.023 15.2 0.8 0.048 14.2 0.8 1.6 1 0 0 1 1 1 0 Dermcidin, antibiotic peptide YejG PF13989.6 EDN03488.1 - 0.07 13.6 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 YejG-like protein SpoVIF PF14069.6 EDN03488.1 - 0.14 11.9 1.1 0.41 10.4 0.3 2.0 2 0 0 2 2 2 0 Stage VI sporulation protein F Cpn60_TCP1 PF00118.24 EDN03490.1 - 4.4e-35 121.2 1.4 5.2e-35 121.0 1.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Peptidase_M48 PF01435.18 EDN03491.1 - 2.6e-33 115.5 0.0 3.6e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 FAD_binding_4 PF01565.23 EDN03494.1 - 9.3e-18 64.3 0.4 2.3e-17 63.0 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EDN03494.1 - 1.1e-08 35.1 0.1 2.2e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like E1_dh PF00676.20 EDN03495.1 - 7.7e-113 376.4 0.1 9.5e-113 376.1 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EDN03495.1 - 0.00022 20.5 0.0 0.00036 19.8 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EDN03495.1 - 0.051 13.4 0.9 0.12 12.1 0.9 1.7 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain S4 PF01479.25 EDN03497.1 - 1.1e-13 50.7 0.0 1.9e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 EDN03497.1 - 0.15 11.9 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 S4 domain SSP160 PF06933.11 EDN03497.1 - 4.4 5.4 10.8 6.2 4.9 10.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Herpes_DNAp_acc PF04929.12 EDN03498.1 - 2.9 6.8 5.5 3.9 6.3 5.5 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor AbiJ_NTD5 PF18865.1 EDN03499.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 AbiJ N-terminal domain 5 DUF5393 PF17371.2 EDN03499.1 - 0.14 10.3 0.1 0.21 9.7 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) CTP_transf_1 PF01148.20 EDN03500.1 - 5.5e-59 200.1 3.1 6.4e-59 199.9 3.1 1.0 1 0 0 1 1 1 1 Cytidylyltransferase family Cyclin_N PF00134.23 EDN03501.1 - 5.2e-09 35.9 0.0 8.5e-08 32.0 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 EDN03501.1 - 0.19 11.8 0.9 1 9.5 0.2 2.3 3 0 0 3 3 3 0 Transcription factor TFIIB repeat zf-C2H2_4 PF13894.6 EDN03502.1 - 2.5e-12 46.5 51.2 0.0076 17.0 0.4 10.3 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN03502.1 - 1.8e-11 43.8 56.5 0.031 14.8 1.0 9.9 10 0 0 10 10 10 7 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDN03502.1 - 1e-07 32.0 45.1 0.099 13.0 0.1 8.8 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding WAC_Acf1_DNA_bd PF10537.9 EDN03502.1 - 2.7e-05 24.6 0.5 0.036 14.6 0.0 2.8 1 1 1 2 2 2 2 ATP-utilising chromatin assembly and remodelling N-terminal zf-met PF12874.7 EDN03502.1 - 0.023 15.1 35.5 0.67 10.4 0.2 7.2 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDN03502.1 - 0.06 13.4 0.1 0.06 13.4 0.1 8.2 9 1 1 10 10 10 0 C2H2-type zinc finger TF_Zn_Ribbon PF08271.12 EDN03502.1 - 3.5 7.2 14.1 5.7 6.5 0.2 4.9 5 0 0 5 5 5 0 TFIIB zinc-binding zf-C2HC_2 PF13913.6 EDN03502.1 - 7.4 6.6 9.1 2.9 7.9 0.2 3.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type GST_N_3 PF13417.6 EDN03503.1 - 3.9e-12 46.4 0.2 8.6e-12 45.3 0.1 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDN03503.1 - 3.2e-11 43.4 0.0 6.3e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDN03503.1 - 1e-06 28.7 0.0 1.9e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDN03503.1 - 8.5e-06 26.0 0.1 3e-05 24.3 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDN03503.1 - 4e-05 23.8 0.0 6.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EDN03503.1 - 0.014 15.9 0.0 0.025 15.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Arm PF00514.23 EDN03504.1 - 4.1e-05 23.4 8.4 3.7 7.7 0.1 7.8 8 1 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDN03504.1 - 0.00077 19.9 1.6 0.14 12.7 0.0 4.6 6 0 0 6 6 6 1 HEAT-like repeat HEAT PF02985.22 EDN03504.1 - 0.028 14.7 1.5 30 5.2 0.0 4.5 4 0 0 4 4 4 0 HEAT repeat Cyclin PF08613.11 EDN03505.1 - 8.4e-17 62.0 1.5 1.5e-16 61.2 0.0 2.0 2 1 0 2 2 2 1 Cyclin BC10 PF06726.12 EDN03506.1 - 5.9e-16 58.5 10.0 8.7e-16 57.9 10.0 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Ge1_WD40 PF16529.5 EDN03507.1 - 0.0027 16.7 0.0 0.0069 15.4 0.0 1.7 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein TRAF_BIRC3_bd PF16673.5 EDN03507.1 - 5.4 6.9 6.1 1 9.2 0.6 2.8 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain CPL PF08144.11 EDN03507.1 - 7.9 6.8 7.0 1 9.7 0.5 2.8 3 0 0 3 3 3 0 CPL (NUC119) domain Glyoxalase PF00903.25 EDN03508.1 - 0.0059 16.8 0.2 0.02 15.1 0.2 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EDN03508.1 - 0.017 15.9 0.0 0.024 15.4 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain Chs7 PF12271.8 EDN03509.1 - 4.6e-109 364.2 1.2 5.2e-109 364.0 1.2 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone MASE3 PF17159.4 EDN03509.1 - 0.12 12.0 10.2 0.39 10.3 1.3 2.2 2 0 0 2 2 2 0 Membrane-associated sensor domain GRA6 PF05084.13 EDN03509.1 - 0.25 11.3 0.1 0.37 10.7 0.1 1.2 1 0 0 1 1 1 0 Granule antigen protein (GRA6) DUF2569 PF10754.9 EDN03509.1 - 0.51 10.8 10.7 4.7 7.7 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF423 PF04241.15 EDN03509.1 - 2.4 8.4 8.2 1.4 9.2 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF423) CD52 PF15116.6 EDN03510.1 - 0.31 11.1 1.8 0.51 10.4 1.8 1.3 1 0 0 1 1 1 0 CAMPATH-1 antigen UCH PF00443.29 EDN03511.1 - 2.3e-21 76.5 0.7 2.1e-19 70.0 0.7 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN03511.1 - 1.7e-06 27.8 0.1 0.0097 15.5 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4 PF00097.25 EDN03512.1 - 9.2e-08 31.8 8.1 1.7e-07 31.0 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN03512.1 - 5.1e-07 29.4 6.1 1.9e-06 27.6 2.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN03512.1 - 9.1e-07 28.8 3.0 9.1e-07 28.8 3.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EDN03512.1 - 1.1e-05 25.5 5.8 5.9e-05 23.1 6.3 1.9 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EDN03512.1 - 1.5e-05 25.2 8.8 6.5e-05 23.2 9.0 1.9 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN03512.1 - 2.3e-05 24.2 6.5 4.8e-05 23.1 6.5 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDN03512.1 - 2.3e-05 24.3 4.4 4.5e-05 23.3 4.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDN03512.1 - 0.055 13.3 8.0 0.4 10.6 8.0 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 PucR PF07905.11 EDN03512.1 - 0.059 13.6 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family zf-RING_10 PF16685.5 EDN03512.1 - 0.19 11.9 2.0 0.43 10.7 2.0 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 FYVE PF01363.21 EDN03512.1 - 0.84 9.8 2.8 2.4 8.4 2.8 1.7 1 1 0 1 1 1 0 FYVE zinc finger zf-rbx1 PF12678.7 EDN03512.1 - 1.2 9.5 7.2 3.6 8.0 7.2 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EDN03512.1 - 3.8 7.3 8.6 3.3 7.5 4.6 2.6 2 1 0 2 2 2 0 RING-like zinc finger ERG4_ERG24 PF01222.17 EDN03513.1 - 2e-141 471.7 17.4 2.3e-141 471.5 17.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Methyltransf_23 PF13489.6 EDN03514.1 - 2.5e-20 72.9 0.0 5.8e-20 71.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN03514.1 - 6.3e-07 30.0 0.0 5.2e-05 23.9 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN03514.1 - 4.5e-06 27.3 0.0 0.041 14.6 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDN03514.1 - 4.6e-06 27.2 0.0 0.14 12.8 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EDN03514.1 - 1.6e-05 24.8 0.0 0.0057 16.5 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain FtsJ PF01728.19 EDN03514.1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF3606 PF12244.8 EDN03514.1 - 0.022 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) DUF938 PF06080.12 EDN03514.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 EDN03514.1 - 0.047 13.0 0.0 0.18 11.1 0.0 1.9 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EDN03514.1 - 0.086 12.4 0.0 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EDN03514.1 - 0.099 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase RNase_H PF00075.24 EDN03515.1 - 3.7e-37 127.7 0.0 6.5e-37 126.9 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EDN03515.1 - 2.2e-35 120.7 8.2 5e-19 68.3 0.4 2.4 2 0 0 2 2 2 2 Caulimovirus viroplasmin RVT_3 PF13456.6 EDN03515.1 - 0.034 13.9 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like Pkinase PF00069.25 EDN03516.1 - 7.5e-35 120.6 0.0 1.3e-34 119.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03516.1 - 1.5e-23 83.4 0.0 2.2e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN03516.1 - 2.7e-05 23.7 0.0 3.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDN03516.1 - 0.0024 16.9 0.0 0.0037 16.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDN03516.1 - 0.0088 14.9 0.0 0.021 13.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase ABC_tran_CTD PF16326.5 EDN03517.1 - 2.1 8.7 7.1 8.1 6.8 2.2 3.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain FMN_dh PF01070.18 EDN03518.1 - 2.6e-59 201.0 2.5 8.4e-50 169.7 1.7 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDN03518.1 - 6.6e-22 77.4 0.0 1.7e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDN03518.1 - 1.4e-06 27.7 0.1 2.1e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EDN03518.1 - 4.5e-06 25.9 0.0 9.3e-06 24.9 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EDN03518.1 - 0.016 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 EDN03518.1 - 0.021 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family ATP11 PF06644.11 EDN03518.1 - 0.046 13.5 0.1 0.066 13.0 0.1 1.2 1 0 0 1 1 1 0 ATP11 protein NMO PF03060.15 EDN03518.1 - 0.12 11.7 0.3 0.2 11.0 0.3 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase B2-adapt-app_C PF09066.10 EDN03518.1 - 0.19 11.9 0.0 0.45 10.6 0.0 1.6 1 1 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain DUF202 PF02656.15 EDN03519.1 - 2.7e-05 24.5 1.3 3.8e-05 24.0 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF202) 6PF2K PF01591.18 EDN03520.1 - 6e-68 228.5 0.0 1.2e-46 158.8 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDN03520.1 - 6.5e-32 110.8 0.0 3.5e-24 85.6 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDN03520.1 - 0.00062 20.0 0.0 0.36 11.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain KTI12 PF08433.10 EDN03520.1 - 0.04 13.4 0.0 0.083 12.3 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 VTC PF09359.10 EDN03521.1 - 2.6e-86 289.4 0.1 4.2e-86 288.8 0.1 1.3 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 EDN03521.1 - 9.2e-11 42.0 7.9 2.2e-10 40.8 6.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EDN03521.1 - 3.4e-07 30.5 15.6 0.00011 22.3 0.7 3.6 2 1 2 4 4 4 2 SPX domain CYTH PF01928.21 EDN03521.1 - 5.8e-05 23.1 0.1 0.00015 21.8 0.1 1.6 1 0 0 1 1 1 1 CYTH domain Wbp11 PF09429.10 EDN03521.1 - 0.76 10.2 3.3 1.2 9.5 1.2 2.3 2 0 0 2 2 2 0 WW domain binding protein 11 DUF1690 PF07956.11 EDN03521.1 - 2.7 8.4 7.2 0.31 11.4 2.6 1.8 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) CBFD_NFYB_HMF PF00808.23 EDN03522.1 - 4.1e-06 27.0 0.1 5.4e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 EDN03522.1 - 2.5e-05 24.4 0.1 2.8e-05 24.2 0.1 1.1 1 0 0 1 1 1 1 CENP-W protein GIDA_assoc PF13932.6 EDN03523.1 - 0.96 9.6 5.2 2 8.5 5.2 1.5 1 0 0 1 1 1 0 GidA associated domain MFS_1 PF07690.16 EDN03524.1 - 2.4e-17 62.9 6.9 2.4e-17 62.9 6.9 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily MMU163 PF17119.5 EDN03525.1 - 1.5e-34 119.3 5.6 6.3e-33 114.0 5.6 2.0 1 1 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis Mcl1_mid PF12341.8 EDN03527.1 - 8.3e-97 324.1 0.0 1.2e-95 320.3 0.0 2.6 3 1 1 4 4 4 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EDN03527.1 - 1.2e-17 64.0 3.7 5.7e-07 30.1 0.0 6.9 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN03527.1 - 2.8e-15 56.4 0.1 0.0002 21.6 0.0 6.2 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EDN03527.1 - 6.5e-06 25.4 0.0 3e-05 23.3 0.0 2.0 1 1 0 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 EDN03527.1 - 0.00037 20.4 0.0 0.12 12.2 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A DNA_pol_alpha_N PF12254.8 EDN03527.1 - 0.01 15.9 3.8 0.031 14.3 3.8 1.8 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal MMS1_N PF10433.9 EDN03527.1 - 0.038 12.6 0.0 0.7 8.5 0.0 2.8 4 0 0 4 4 4 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Collagen_bind_2 PF12904.7 EDN03527.1 - 0.091 12.8 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase p450 PF00067.22 EDN03528.1 - 2.3e-12 46.4 0.0 4.4e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Amidase PF01425.21 EDN03530.1 - 6.3e-47 160.6 0.1 7.7e-47 160.3 0.1 1.1 1 0 0 1 1 1 1 Amidase RNA12 PF10443.9 EDN03531.1 - 2e-56 191.6 0.0 2.4e-55 188.0 0.0 1.9 1 1 0 1 1 1 1 RNA12 protein DUF4599 PF15371.6 EDN03531.1 - 0.029 14.9 0.1 0.069 13.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4599) Glu_synthase PF01645.17 EDN03532.1 - 1e-155 518.5 0.0 1.8e-155 517.6 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase GATase_2 PF00310.21 EDN03532.1 - 1.1e-146 488.9 0.0 1.5e-146 488.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 EDN03532.1 - 2e-116 388.3 0.0 6.2e-113 376.9 0.0 2.2 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 EDN03532.1 - 3.8e-86 287.6 2.0 6.7e-86 286.8 2.0 1.4 1 0 0 1 1 1 1 GXGXG motif FMN_dh PF01070.18 EDN03532.1 - 0.032 13.2 0.9 0.15 11.1 0.8 1.9 2 0 0 2 2 2 0 FMN-dependent dehydrogenase HSP70 PF00012.20 EDN03533.1 - 2.5e-108 362.8 1.9 4.3e-108 362.1 0.3 1.6 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EDN03533.1 - 4.9e-11 42.0 0.0 7.5e-11 41.4 0.0 1.3 1 1 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EDN03533.1 - 0.016 14.5 0.1 0.024 13.9 0.1 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase StbA PF06406.11 EDN03533.1 - 0.069 12.4 0.0 0.097 11.9 0.0 1.2 1 0 0 1 1 1 0 StbA protein CHZ PF09649.10 EDN03534.1 - 4.4e-15 54.8 0.4 4.4e-15 54.8 0.4 2.2 2 0 0 2 2 2 1 Histone chaperone domain CHZ EBV-NA3 PF05009.12 EDN03534.1 - 3.8 7.0 6.7 25 4.3 3.8 2.1 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Apc15p PF05841.11 EDN03537.1 - 6.4e-18 65.8 0.8 6.4e-18 65.8 0.8 1.8 2 0 0 2 2 2 1 Apc15p protein Mito_carr PF00153.27 EDN03538.1 - 2.3e-06 27.4 0.3 7e-05 22.7 0.0 2.5 2 1 0 2 2 2 1 Mitochondrial carrier protein NUDE_C PF04880.13 EDN03538.1 - 2.2 8.7 4.4 4.2 7.8 4.0 1.6 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region Coprogen_oxidas PF01218.18 EDN03539.1 - 3.8e-135 449.4 0.0 8.2e-135 448.2 0.0 1.5 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.11 EDN03539.1 - 0.13 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1651) HOOK PF05622.12 EDN03540.1 - 8.9e-25 87.0 60.6 2.5e-24 85.4 60.6 1.9 1 1 0 1 1 1 1 HOOK protein KASH_CCD PF14662.6 EDN03540.1 - 0.00082 19.2 16.7 0.00082 19.2 16.7 6.6 3 2 3 6 6 5 3 Coiled-coil region of CCDC155 or KASH DUF2353 PF09789.9 EDN03540.1 - 0.0031 16.9 10.7 0.0031 16.9 10.7 5.1 3 1 1 4 4 4 1 Uncharacterized coiled-coil protein (DUF2353) CENP-F_leu_zip PF10473.9 EDN03540.1 - 0.0036 17.3 14.1 0.0036 17.3 14.1 6.6 3 2 3 6 6 6 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fibin PF15819.5 EDN03540.1 - 0.0065 16.2 1.2 0.0065 16.2 1.2 4.4 3 2 3 6 6 5 1 Fin bud initiation factor homologue Acyl-CoA_dh_C PF12806.7 EDN03540.1 - 0.033 14.3 4.3 3.1 8.0 0.2 4.4 4 1 0 4 4 4 0 Acetyl-CoA dehydrogenase C-terminal like Baculo_PEP_C PF04513.12 EDN03540.1 - 0.095 12.7 0.1 0.095 12.7 0.1 6.0 5 2 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliJ PF02050.16 EDN03540.1 - 0.35 11.1 55.4 0.051 13.8 10.2 6.4 2 2 3 6 6 5 0 Flagellar FliJ protein Pox_A_type_inc PF04508.12 EDN03540.1 - 0.43 10.5 0.0 0.43 10.5 0.0 5.6 6 0 0 6 6 5 0 Viral A-type inclusion protein repeat HALZ PF02183.18 EDN03540.1 - 0.5 10.6 26.6 2 8.7 1.1 6.9 5 1 1 6 6 6 0 Homeobox associated leucine zipper HTH_57 PF18679.1 EDN03540.1 - 1.1 9.6 10.6 0.34 11.2 0.1 4.2 4 0 0 4 4 4 0 ThcOx helix turn helix domain NPV_P10 PF05531.12 EDN03540.1 - 1.7 9.2 37.0 0.23 12.0 2.3 7.0 5 2 0 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF573 PF04504.14 EDN03544.1 - 8.2e-06 26.4 0.1 1.9e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN03544.1 - 6.9e-05 23.0 0.1 0.00016 21.8 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN03544.1 - 0.008 16.4 0.1 0.018 15.3 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN03544.1 - 0.028 14.8 2.4 0.3 11.5 2.4 2.3 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain OrsD PF12013.8 EDN03545.1 - 2.2e-37 128.0 4.8 8.8e-37 126.0 4.8 2.2 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D Helicase_C PF00271.31 EDN03545.1 - 9.5e-15 54.9 0.1 2.5e-14 53.5 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN03545.1 - 2.4e-13 50.2 0.0 9e-13 48.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN03545.1 - 4.9e-07 29.9 0.0 3.4e-06 27.2 0.0 2.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit zf-H2C2_5 PF13909.6 EDN03545.1 - 0.32 10.8 3.5 1.4 8.7 1.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DDE_Tnp_1_7 PF13843.6 EDN03547.1 - 0.028 13.7 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Transposase IS4 KIAA1328 PF15369.6 EDN03548.1 - 0.037 13.9 0.7 0.04 13.7 0.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Ste5 PF11610.8 EDN03550.1 - 0.0088 15.9 14.0 3.6 7.6 0.1 4.8 5 0 0 5 5 5 3 Scaffold protein Ste5, Fus3-binding region CaATP_NAI PF12515.8 EDN03550.1 - 0.1 12.3 8.1 12 5.6 0.3 3.7 1 1 2 3 3 3 0 Ca2+-ATPase N terminal autoinhibitory domain DNA_pol_E_B PF04042.16 EDN03550.1 - 0.42 9.9 3.1 35 3.7 3.1 3.2 1 1 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B DUF2244 PF10003.9 EDN03550.1 - 0.85 9.3 2.7 21 4.7 0.1 2.4 1 1 2 3 3 3 0 Integral membrane protein (DUF2244) Helicase_C PF00271.31 EDN03551.1 - 9.2e-13 48.5 0.0 1.9e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DDE_Tnp_1_7 PF13843.6 EDN03552.1 - 0.028 13.7 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Transposase IS4 zf-CCHC PF00098.23 EDN03553.1 - 0.001 19.0 2.8 0.0018 18.2 2.8 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotran_gag_2 PF14223.6 EDN03553.1 - 0.0013 18.4 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF2795 PF11387.8 EDN03553.1 - 0.071 13.3 0.0 3 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) zf-CCHC_5 PF14787.6 EDN03553.1 - 0.51 10.1 2.7 1.1 9.0 2.7 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVT_2 PF07727.14 EDN03554.1 - 1.5e-43 149.2 0.0 2.4e-43 148.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN03554.1 - 1.9e-12 47.4 0.1 6.2e-12 45.8 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN03554.1 - 0.03 14.0 3.0 0.057 13.1 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN03554.1 - 0.033 14.0 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN03554.1 - 0.091 12.6 0.1 0.29 11.0 0.1 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_2 PF14223.6 EDN03554.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Pkinase PF00069.25 EDN03555.1 - 3.4e-08 33.2 0.0 9.9e-08 31.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN03555.1 - 2.4e-06 27.7 0.0 2.4e-06 27.7 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN03555.1 - 0.00044 19.7 0.0 0.00081 18.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EDN03555.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase HSDR_N_2 PF13588.6 EDN03555.1 - 0.017 15.1 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Choline_kinase PF01633.20 EDN03555.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Chromo PF00385.24 EDN03556.1 - 0.002 18.0 1.4 0.0032 17.3 0.2 2.0 2 1 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain gag_pre-integrs PF13976.6 EDN03557.1 - 5.4e-08 32.6 0.0 1.3e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EDN03557.1 - 6e-07 29.7 0.0 6.7e-06 26.3 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain DUF4219 PF13961.6 EDN03557.1 - 4.2e-05 23.1 0.1 0.00014 21.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) Retrotran_gag_2 PF14223.6 EDN03557.1 - 0.026 14.2 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type YpjP PF14005.6 EDN03557.1 - 0.1 12.6 0.0 1.8 8.6 0.0 2.3 2 0 0 2 2 2 0 YpjP-like protein RVT_2 PF07727.14 EDN03558.1 - 1.4e-47 162.4 0.0 5.5e-37 127.7 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_8 PF02954.19 EDN03560.1 - 0.0096 15.7 0.1 0.23 11.3 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family HTH_Tnp_Tc5 PF03221.16 EDN03560.1 - 0.15 12.1 0.1 0.62 10.1 0.0 2.2 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain RVT_1 PF00078.27 EDN03561.1 - 2.1e-22 79.7 0.0 3.1e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 EDN03561.1 - 0.06 14.1 1.1 0.16 12.7 0.3 2.1 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase Exo_endo_phos_2 PF14529.6 EDN03562.1 - 7.1e-14 51.7 0.0 1.8e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 EDN03562.1 - 9.2e-08 31.9 0.0 1.4e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 EDN03562.1 - 3.4e-05 23.5 0.0 5.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RNase_H PF00075.24 EDN03564.1 - 2.2e-12 47.4 0.0 4.6e-12 46.3 0.0 1.5 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN03564.1 - 0.096 12.5 0.0 0.38 10.6 0.1 2.0 2 1 0 2 2 2 0 Reverse transcriptase-like EKLF_TAD1 PF16832.5 EDN03564.1 - 6.6 6.7 5.6 2.5 8.0 0.2 2.7 3 0 0 3 3 3 0 Erythroid krueppel-like transcription factor, transactivation 1 DDE_3 PF13358.6 EDN03565.1 - 5.8e-05 22.9 0.1 0.00011 22.0 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EDN03566.1 - 6.3e-27 93.6 0.0 1e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EDN03566.1 - 1.2e-05 25.8 0.3 4.6e-05 23.9 0.0 2.1 3 0 0 3 3 3 1 Homeodomain-like domain HTH_33 PF13592.6 EDN03566.1 - 0.0063 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_21 PF13276.6 EDN03566.1 - 0.007 16.5 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 HTH-like domain HTH_23 PF13384.6 EDN03566.1 - 0.022 14.5 0.1 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HTH_10 PF04967.12 EDN03566.1 - 0.18 11.6 0.1 6.3 6.7 0.0 2.6 2 1 0 2 2 2 0 HTH DNA binding domain DDE_1 PF03184.19 EDN03567.1 - 3.6e-08 33.3 0.0 7.1e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Lyase_1 PF00206.20 EDN03568.1 - 4.3e-23 82.2 0.1 6.9e-23 81.5 0.1 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EDN03568.1 - 2.7e-16 59.9 0.1 1.2e-15 57.8 0.0 2.2 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus RNase_H PF00075.24 EDN03569.1 - 1.4e-07 31.8 0.0 2.5e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 RNase H Baculo_PEP_C PF04513.12 EDN03570.1 - 0.13 12.3 0.8 0.94 9.5 0.1 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SPX PF03105.19 EDN03571.1 - 3.6e-74 251.0 0.0 3.6e-74 251.0 0.0 1.9 2 0 0 2 2 2 1 SPX domain EXS PF03124.14 EDN03571.1 - 2.7e-66 224.2 16.5 1.1e-56 192.5 10.4 2.1 1 1 1 2 2 2 2 EXS family OEP PF02321.18 EDN03571.1 - 1.2 9.0 4.5 5.2 6.8 0.2 2.7 3 0 0 3 3 3 0 Outer membrane efflux protein Abhydrolase_1 PF00561.20 EDN03572.1 - 4.3e-48 164.2 0.1 6e-48 163.7 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN03572.1 - 0.00021 22.0 4.3 0.00042 21.0 4.3 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 EDN03572.1 - 0.095 11.5 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase RT_RNaseH PF17917.1 EDN03574.1 - 1.6e-28 99.1 0.3 6.1e-28 97.2 0.2 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN03574.1 - 6.3e-17 61.4 0.1 1.9e-16 59.9 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 EDN03574.1 - 2.9e-15 56.1 0.0 8.7e-15 54.6 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase NCBP3 PF10309.9 EDN03574.1 - 0.21 11.5 0.5 0.48 10.3 0.5 1.5 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 VPS9 PF02204.18 EDN03575.1 - 7.7e-18 64.6 0.1 2.2e-17 63.1 0.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EDN03575.1 - 3.7e-17 62.2 0.0 1.6e-14 53.8 0.0 4.3 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDN03575.1 - 2.5e-11 44.0 0.0 0.00017 22.1 0.0 3.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) PX PF00787.24 EDN03575.1 - 4.6e-06 26.6 0.1 1.2e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 PX domain Ank_3 PF13606.6 EDN03575.1 - 2.1e-05 24.6 0.0 0.21 12.3 0.0 5.1 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 EDN03575.1 - 5.8e-05 23.6 0.3 0.36 11.5 0.0 4.8 2 2 3 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN03575.1 - 0.00068 20.0 0.0 7.5 7.2 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat HisKA_3 PF07730.13 EDN03575.1 - 0.38 11.3 4.9 0.33 11.5 1.1 2.9 4 0 0 4 4 4 0 Histidine kinase Ribosomal_S11 PF00411.19 EDN03577.1 - 1.8e-09 38.0 0.0 2.9e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 mRNA_stabil PF13929.6 EDN03577.1 - 0.066 12.2 0.0 0.096 11.7 0.0 1.1 1 0 0 1 1 1 0 mRNA stabilisation Toxin-JAB1 PF15659.6 EDN03577.1 - 0.12 12.8 1.9 0.19 12.1 1.9 1.3 1 0 0 1 1 1 0 JAB-like toxin 1 Tim44 PF04280.15 EDN03578.1 - 1.1e-35 122.9 0.1 2.7e-35 121.7 0.0 1.7 2 0 0 2 2 2 1 Tim44-like domain IGF2_C PF08365.11 EDN03578.1 - 0.0024 17.8 0.4 0.0096 15.9 0.4 2.1 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide MDM10 PF12519.8 EDN03578.1 - 0.32 9.8 6.6 0.61 8.9 6.6 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SOG2 PF10428.9 EDN03578.1 - 2.7 7.1 13.9 4 6.5 13.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3347 PF11827.8 EDN03578.1 - 4.2 7.5 13.5 0.83 9.8 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3347) STI1 PF17830.1 EDN03579.1 - 1.1e-06 28.4 12.3 0.00011 22.0 8.2 2.2 2 0 0 2 2 2 2 STI1 domain GerD PF17898.1 EDN03579.1 - 0.011 15.7 1.3 0.79 9.7 0.8 2.2 2 0 0 2 2 2 0 Spore germination GerD central core domain XPC-binding PF09280.11 EDN03579.1 - 0.014 15.1 4.4 0.026 14.2 1.3 2.4 2 1 0 2 2 2 0 XPC-binding domain Collar PF07484.12 EDN03579.1 - 0.023 14.7 0.3 0.91 9.6 0.1 2.3 2 0 0 2 2 2 0 Phage Tail Collar Domain RIC1 PF07064.13 EDN03580.1 - 5.9e-40 137.3 0.0 2.5e-24 86.1 0.0 3.3 1 1 2 3 3 3 3 RIC1 Pre-PUA PF17832.1 EDN03581.1 - 1.3e-22 80.3 0.3 1.8e-22 79.8 0.3 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EDN03581.1 - 1.3e-13 50.7 0.5 2.6e-13 49.7 0.5 1.6 1 1 0 1 1 1 1 PUA domain YchF-GTPase_C PF06071.13 EDN03582.1 - 3.5e-34 116.9 0.2 8.3e-34 115.6 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EDN03582.1 - 5.1e-17 62.0 0.0 1.3e-16 60.7 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN03582.1 - 0.0015 18.1 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B PPAK PF02818.15 EDN03582.1 - 0.04 14.1 1.4 0.13 12.4 1.4 1.9 1 0 0 1 1 1 0 PPAK motif CBM_X2 PF03442.14 EDN03582.1 - 0.068 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain X2 TGS PF02824.21 EDN03582.1 - 0.087 12.9 0.2 0.34 11.0 0.2 2.0 1 1 0 1 1 1 0 TGS domain CHCH PF06747.13 EDN03585.1 - 0.00079 19.5 0.1 0.0012 19.0 0.1 1.3 1 0 0 1 1 1 1 CHCH domain COX17 PF05051.13 EDN03585.1 - 0.021 15.2 2.1 0.27 11.6 0.1 2.2 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Pet191_N PF10203.9 EDN03585.1 - 0.057 13.7 1.4 0.2 12.0 1.6 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 NPR3 PF03666.13 EDN03586.1 - 3.3e-107 359.2 1.7 3.4e-60 204.2 0.2 4.0 3 1 1 4 4 4 2 Nitrogen Permease regulator of amino acid transport activity 3 RRN3 PF05327.11 EDN03586.1 - 0.78 8.2 2.8 1.7 7.1 2.8 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Thioesterase PF00975.20 EDN03587.1 - 0.037 14.1 0.0 0.041 14.0 0.0 1.3 1 1 0 1 1 1 0 Thioesterase domain AMP-binding PF00501.28 EDN03588.1 - 1.8e-47 161.9 0.0 7.3e-47 159.9 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme RVT_2 PF07727.14 EDN03589.1 - 6e-35 121.0 0.0 1e-34 120.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN03589.1 - 1.8e-12 47.5 0.1 4.6e-12 46.2 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN03589.1 - 0.023 14.4 3.0 0.045 13.5 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN03589.1 - 0.025 14.4 0.0 0.068 13.0 0.0 1.7 1 0 0 1 1 1 0 GAG-pre-integrase domain NDUFA12 PF05071.16 EDN03589.1 - 0.52 11.2 3.1 0.39 11.6 0.2 2.4 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 La PF05383.17 EDN03590.1 - 4.1e-18 65.2 1.2 6.4e-18 64.6 0.3 1.8 2 0 0 2 2 2 1 La domain GRP PF07172.11 EDN03590.1 - 7.8 7.3 14.0 4.6 8.0 5.7 3.5 2 0 0 2 2 2 0 Glycine rich protein family Band_7 PF01145.25 EDN03591.1 - 1.8e-30 106.3 0.9 3e-30 105.5 0.9 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EDN03591.1 - 2.1e-24 85.3 1.2 6.9e-24 83.7 1.2 2.0 1 0 0 1 1 1 1 C-terminal region of band_7 DRTGG PF07085.12 EDN03591.1 - 0.035 13.9 1.0 0.46 10.3 0.0 2.4 1 1 0 2 2 2 0 DRTGG domain Pox_A11 PF05061.13 EDN03591.1 - 0.05 12.9 1.1 0.16 11.3 0.7 1.7 1 1 1 2 2 2 0 Poxvirus A11 Protein Hira PF07569.11 EDN03592.1 - 1.2e-79 267.1 0.0 2.9e-79 265.9 0.0 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 EDN03592.1 - 7.6e-23 80.4 27.8 7.9e-05 23.4 0.0 9.0 7 2 2 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN03592.1 - 3.9e-11 43.1 0.0 0.015 15.6 0.0 5.5 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EDN03592.1 - 2e-10 40.2 0.2 5.3e-10 38.9 0.2 1.8 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 EDN03592.1 - 3.1e-06 27.0 0.9 15 5.7 0.0 5.9 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EDN03592.1 - 0.0049 15.9 0.0 0.19 10.6 0.0 2.9 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EDN03592.1 - 0.19 9.7 0.0 0.97 7.3 0.0 2.0 3 0 0 3 3 3 0 IKI3 family DDE_1 PF03184.19 EDN03593.1 - 1.1e-33 116.4 0.0 1.9e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN03593.1 - 8.2e-11 41.8 0.0 1.6e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN03593.1 - 1e-05 25.3 0.1 0.00041 20.1 0.0 2.6 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_psq PF05225.16 EDN03593.1 - 8e-05 22.3 0.1 0.00022 20.9 0.1 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.19 EDN03594.1 - 3.6e-24 85.4 0.3 3.5e-23 82.1 0.2 2.5 2 1 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN03594.1 - 0.058 13.1 0.1 8.4 6.1 0.0 2.8 3 0 0 3 3 3 0 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN03594.1 - 0.067 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain RT_RNaseH PF17917.1 EDN03595.1 - 7.4e-35 119.4 0.0 6.4e-34 116.4 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN03595.1 - 4.1e-31 108.2 0.0 7.1e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN03595.1 - 9.8e-24 83.3 0.3 1.7e-12 47.3 0.0 3.1 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase Chromo PF00385.24 EDN03595.1 - 6.4e-14 51.6 1.5 1.9e-13 50.1 1.5 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN03595.1 - 1.3e-13 51.2 0.0 5.1e-13 49.3 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 EDN03595.1 - 1.9e-05 24.5 1.2 3.9e-05 23.5 1.2 1.6 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 EDN03595.1 - 0.00062 20.0 2.9 0.00062 20.0 2.9 2.9 2 0 0 2 2 2 1 Retrotransposon gag protein Mtf2_C PF14061.6 EDN03595.1 - 0.03 14.5 1.0 0.35 11.1 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 zf-CCHC_2 PF13696.6 EDN03595.1 - 0.059 13.2 0.4 0.16 11.8 0.4 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN03595.1 - 0.19 11.5 0.8 0.4 10.5 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle Retrotran_gag_2 PF14223.6 EDN03595.1 - 0.34 10.6 1.6 0.83 9.3 1.6 1.6 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type TackOD1 PF18551.1 EDN03596.1 - 0.45 10.2 4.5 0.67 9.6 4.5 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 rve PF00665.26 EDN03598.1 - 4.9e-14 52.6 0.0 1.3e-13 51.1 0.0 1.8 1 1 1 2 2 2 1 Integrase core domain RVT_1 PF00078.27 EDN03599.1 - 4.2e-08 33.0 0.1 1.8e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) TSNAXIP1_N PF15739.5 EDN03599.1 - 0.052 13.9 0.6 0.15 12.4 0.6 1.8 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus Asp_protease_2 PF13650.6 EDN03599.1 - 0.068 13.8 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease DUF4625 PF15418.6 EDN03599.1 - 0.15 12.3 0.8 0.47 10.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) PIN_8 PF18476.1 EDN03599.1 - 1.2 9.0 7.5 0.53 10.1 4.2 2.1 1 1 1 2 2 2 0 PIN like domain NDUFA12 PF05071.16 EDN03599.1 - 8.4 7.3 9.2 1.4 9.8 4.7 2.0 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 RNase_H PF00075.24 EDN03600.1 - 1.4e-12 48.0 0.0 3.1e-12 46.9 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN03600.1 - 0.066 13.0 0.1 0.21 11.4 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like PAP2 PF01569.21 EDN03601.1 - 1.4e-11 44.3 4.2 5.9e-11 42.3 0.5 2.9 2 1 0 2 2 2 1 PAP2 superfamily Sulf_transp PF04143.14 EDN03601.1 - 0.03 13.9 1.7 0.064 12.8 0.4 1.9 1 1 0 2 2 2 0 Sulphur transport Mod_r PF07200.13 EDN03602.1 - 1.8e-26 93.0 2.8 2.2e-26 92.7 2.8 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein PSK_trans_fac PF07704.11 EDN03602.1 - 0.03 15.1 1.7 0.065 14.0 1.7 1.5 1 0 0 1 1 1 0 Rv0623-like transcription factor Ank_5 PF13857.6 EDN03603.1 - 3.1e-08 33.7 0.2 8.4e-08 32.3 0.1 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN03603.1 - 2.7e-06 27.8 0.0 6e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN03603.1 - 1.1e-05 25.4 0.0 0.00027 21.1 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EDN03603.1 - 3e-05 24.5 0.0 5.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EDN03603.1 - 0.0017 18.7 0.1 0.0063 16.9 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeat YejG PF13989.6 EDN03603.1 - 0.0021 18.5 0.0 0.0035 17.8 0.0 1.3 1 0 0 1 1 1 1 YejG-like protein tRNA_lig_CPD PF08302.11 EDN03604.1 - 5.1e-95 317.7 0.0 7.2e-95 317.2 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 EDN03604.1 - 8.6e-84 280.8 0.1 2.6e-83 279.2 0.0 1.9 2 0 0 2 2 2 1 RNA ligase tRNA_lig_kinase PF08303.11 EDN03604.1 - 4.5e-49 166.7 0.1 8.5e-49 165.9 0.1 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_18 PF13238.6 EDN03604.1 - 0.062 13.9 0.0 0.28 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Got1 PF04178.12 EDN03605.1 - 2.7e-34 118.0 16.4 2.7e-34 118.0 16.4 1.9 2 1 0 2 2 2 1 Got1/Sft2-like family DUF2569 PF10754.9 EDN03605.1 - 1 9.8 10.6 0.091 13.2 4.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) HLH PF00010.26 EDN03606.1 - 3.4e-12 46.1 0.0 1.1e-11 44.5 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_carr PF00153.27 EDN03607.1 - 4e-12 45.9 0.0 4.4e-12 45.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Dna2 PF08696.11 EDN03608.1 - 2.5e-70 236.5 0.0 2.1e-69 233.4 0.0 2.4 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.6 EDN03608.1 - 2.5e-52 177.4 0.0 4.3e-52 176.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDN03608.1 - 3.9e-33 115.3 0.1 5.2e-17 62.5 0.0 2.7 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EDN03608.1 - 2.1e-14 53.7 0.0 4.4e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cas_Cas4 PF01930.17 EDN03608.1 - 2.5e-12 47.2 0.2 5.3e-10 39.6 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF83 AAA_19 PF13245.6 EDN03608.1 - 2.3e-11 44.3 0.1 4.7e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDN03608.1 - 2.4e-07 30.8 0.9 0.27 11.0 0.1 3.5 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase Csa1 PF06023.12 EDN03608.1 - 3.1e-05 23.5 0.1 0.00013 21.5 0.1 1.9 1 1 0 1 1 1 1 CRISPR-associated exonuclease Csa1 Helicase_RecD PF05127.14 EDN03608.1 - 0.00015 21.7 0.0 0.00038 20.4 0.0 1.7 1 0 0 1 1 1 1 Helicase SRP54 PF00448.22 EDN03608.1 - 0.00031 20.4 0.1 0.00056 19.6 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain CbiA PF01656.23 EDN03608.1 - 0.00041 20.4 0.1 0.0011 19.0 0.1 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain PIF1 PF05970.14 EDN03608.1 - 0.00067 18.9 0.0 0.0013 18.0 0.0 1.5 1 0 0 1 1 1 1 PIF1-like helicase UvrD-helicase PF00580.21 EDN03608.1 - 0.0015 18.1 0.2 0.004 16.7 0.2 1.7 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EDN03608.1 - 0.0017 18.8 0.0 0.0045 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain cobW PF02492.19 EDN03608.1 - 0.0021 17.7 0.0 0.011 15.3 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EDN03608.1 - 0.0057 16.6 0.0 0.22 11.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDN03608.1 - 0.0066 16.6 0.1 0.053 13.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 EDN03608.1 - 0.0085 16.0 0.1 0.021 14.7 0.1 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 EDN03608.1 - 0.0089 15.6 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDN03608.1 - 0.014 15.0 0.1 0.032 13.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ResIII PF04851.15 EDN03608.1 - 0.022 14.8 0.1 0.055 13.5 0.1 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EDN03608.1 - 0.024 13.9 0.0 0.048 12.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF853 PF05872.12 EDN03608.1 - 0.036 12.7 0.1 0.06 11.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) FtsK_SpoIIIE PF01580.18 EDN03608.1 - 0.037 13.4 0.1 0.095 12.0 0.1 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 EDN03608.1 - 0.084 11.8 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.17 EDN03608.1 - 0.088 12.9 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain MeaB PF03308.16 EDN03608.1 - 0.1 11.6 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EDN03608.1 - 0.1 13.2 0.0 0.33 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDN03608.1 - 0.12 12.9 0.0 0.35 11.3 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN03608.1 - 0.13 12.5 0.2 0.9 9.8 0.2 2.5 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDN03608.1 - 0.14 12.0 0.1 0.38 10.6 0.1 1.6 1 0 0 1 1 1 0 NTPase Ribonuc_P_40 PF08584.11 EDN03609.1 - 4.1e-10 39.4 0.0 4.6e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit betaPIX_CC PF16523.5 EDN03609.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 betaPIX coiled coil WD40 PF00400.32 EDN03610.1 - 6.3e-24 83.8 15.5 1.3e-06 29.0 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN03610.1 - 1.9e-15 56.9 0.1 0.025 14.9 0.0 6.1 3 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EDN03610.1 - 6.6e-11 41.4 0.0 3.3e-08 32.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 EDN03610.1 - 4.1e-05 23.5 0.1 0.23 11.3 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDN03610.1 - 0.014 14.1 0.3 0.37 9.4 0.0 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 VID27 PF08553.10 EDN03610.1 - 0.021 13.9 0.1 0.38 9.7 0.0 2.0 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain PALB2_WD40 PF16756.5 EDN03610.1 - 0.057 12.3 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain IKI3 PF04762.12 EDN03610.1 - 0.13 10.3 0.0 0.21 9.5 0.0 1.3 1 0 0 1 1 1 0 IKI3 family Coatomer_WDAD PF04053.14 EDN03610.1 - 0.17 10.9 0.0 0.73 8.8 0.0 1.9 2 0 0 2 2 2 0 Coatomer WD associated region Ribosomal_L2_C PF03947.18 EDN03612.1 - 7.2e-40 136.1 1.1 6.7e-39 133.0 1.1 2.4 1 1 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDN03612.1 - 5.5e-28 96.8 0.7 1.1e-27 95.8 0.7 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DUF3881 PF12997.7 EDN03613.1 - 0.52 9.5 3.1 0.36 10.0 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) HIT PF01230.23 EDN03614.1 - 6.4e-15 55.7 0.2 1.4e-14 54.6 0.1 1.6 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EDN03614.1 - 0.0012 19.3 0.3 0.0031 18.0 0.3 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EDN03614.1 - 0.0018 18.1 0.2 0.0072 16.2 0.2 2.0 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 UPF0020 PF01170.18 EDN03615.1 - 6e-08 32.6 0.0 2.7e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EDN03615.1 - 0.0029 16.9 0.0 0.0047 16.2 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase MethyltransfD12 PF02086.15 EDN03615.1 - 0.0056 16.4 0.4 0.017 14.8 0.0 1.9 3 0 0 3 3 3 1 D12 class N6 adenine-specific DNA methyltransferase N6_N4_Mtase PF01555.18 EDN03615.1 - 0.011 15.4 0.0 0.1 12.3 0.0 2.2 2 0 0 2 2 2 0 DNA methylase Mfa_like_2 PF15415.6 EDN03616.1 - 0.12 11.3 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Fimbrillin-like DUF2985 PF11204.8 EDN03617.1 - 4.3e-17 62.0 3.4 9.7e-17 60.9 3.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) DUF1691 PF07950.11 EDN03617.1 - 0.59 10.9 0.0 0.59 10.9 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1691) DUF2681 PF10883.8 EDN03617.1 - 6.1 7.3 8.2 95 3.5 5.9 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2681) SIR2 PF02146.17 EDN03618.1 - 1.7e-59 200.7 0.0 2.4e-59 200.2 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EDN03618.1 - 9.9e-05 22.2 0.2 0.00019 21.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EDN03618.1 - 0.00068 19.4 0.1 0.7 9.6 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain zf-4CXXC_R1 PF10497.9 EDN03618.1 - 0.11 12.7 0.7 0.23 11.7 0.7 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 TPR_12 PF13424.6 EDN03619.1 - 3.1e-10 40.2 0.4 2e-06 28.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN03619.1 - 2.5e-08 33.4 0.0 0.001 19.0 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN03619.1 - 4e-07 29.7 0.1 8.7e-05 22.4 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN03619.1 - 5.6e-07 30.0 8.3 0.0016 18.9 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDN03619.1 - 7.6e-07 29.4 8.1 1.2 10.1 0.0 5.3 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDN03619.1 - 2e-06 27.4 0.1 0.0024 17.6 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN03619.1 - 5.8e-06 26.8 2.9 0.00033 21.2 0.1 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDN03619.1 - 0.00012 21.7 0.1 0.00045 19.8 0.0 2.1 2 0 0 2 2 2 1 TPR repeat TPR_9 PF13371.6 EDN03619.1 - 0.00013 22.1 8.4 1.7 8.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN03619.1 - 0.00064 19.2 0.9 0.11 11.8 0.0 2.5 2 0 0 2 2 2 1 MalT-like TPR region TPR_10 PF13374.6 EDN03619.1 - 0.0014 18.4 1.0 3.3 7.7 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDN03619.1 - 0.0016 17.7 2.2 1.1 8.5 0.0 3.5 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_5 PF12688.7 EDN03619.1 - 0.021 15.1 2.1 4.3 7.6 0.3 2.9 3 0 0 3 3 3 0 Tetratrico peptide repeat TPR_7 PF13176.6 EDN03619.1 - 0.059 13.4 0.9 2.4 8.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EDN03619.1 - 0.074 12.5 0.0 0.29 10.6 0.0 2.0 1 0 0 1 1 1 0 SHNi-TPR TPR_6 PF13174.6 EDN03619.1 - 1.2 10.0 5.4 6.7 7.6 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDN03619.1 - 6.7 7.7 9.1 37 5.3 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat RWD PF05773.22 EDN03620.1 - 1e-26 93.5 1.7 1.2e-26 93.2 0.4 1.8 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EDN03620.1 - 0.014 15.9 11.9 0.035 14.6 11.4 1.9 1 1 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 ketoacyl-synt PF00109.26 EDN03620.1 - 0.064 12.8 0.2 0.098 12.2 0.2 1.2 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Jak1_Phl PF17887.1 EDN03620.1 - 0.24 11.3 4.9 0.4 10.7 4.9 1.2 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Allantoicase PF03561.15 EDN03621.1 - 0.4 10.6 2.8 1.5 8.8 1.1 2.3 1 1 1 2 2 2 0 Allantoicase repeat UQ_con PF00179.26 EDN03622.1 - 1.6e-19 69.9 0.0 1.8e-19 69.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDN03622.1 - 0.023 15.0 0.0 0.024 14.9 0.0 1.2 1 0 0 1 1 1 0 RWD domain Sec7_N PF12783.7 EDN03623.1 - 1.2e-41 142.3 2.0 1.2e-41 142.3 2.0 4.1 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EDN03623.1 - 1.3e-20 73.8 4.9 1.3e-14 54.2 0.2 3.4 3 0 0 3 3 3 2 Dimerisation and cyclophilin-binding domain of Mon2 Mon2_C PF16206.5 EDN03623.1 - 2.6e-18 65.6 3.5 2.6e-18 65.6 3.5 1.9 2 0 0 2 2 2 1 C-terminal region of Mon2 protein DUF1981 PF09324.10 EDN03623.1 - 0.0076 16.1 0.1 0.12 12.3 0.0 3.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) DUF3926 PF13080.6 EDN03623.1 - 0.28 11.2 2.2 0.81 9.7 2.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) Vps26 PF03643.15 EDN03624.1 - 2.4e-101 338.4 0.2 3.1e-101 338.0 0.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 AAA_33 PF13671.6 EDN03625.1 - 4.8e-10 39.7 0.0 1.1e-09 38.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDN03625.1 - 9.4e-10 39.1 0.6 6.6e-09 36.4 0.6 2.2 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 EDN03625.1 - 2.8e-09 37.3 0.9 0.00063 19.9 0.0 2.4 2 1 0 2 2 2 2 Shikimate kinase Rad17 PF03215.15 EDN03625.1 - 1.3e-07 31.8 0.0 2.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_17 PF13207.6 EDN03625.1 - 8.1e-06 26.3 0.1 0.015 15.7 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDN03625.1 - 1.1e-05 25.7 0.1 2.9e-05 24.3 0.0 1.6 1 1 0 2 2 1 1 AAA domain NACHT PF05729.12 EDN03625.1 - 2.9e-05 24.0 0.0 5.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain dNK PF01712.19 EDN03625.1 - 5.9e-05 23.0 0.2 0.0078 16.1 0.0 2.3 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA PF00004.29 EDN03625.1 - 0.0001 22.7 0.0 0.00021 21.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EDN03625.1 - 0.00011 22.0 0.0 0.00025 20.9 0.0 1.5 1 0 0 1 1 1 1 Cytidylate kinase AAA_16 PF13191.6 EDN03625.1 - 0.00068 20.0 0.0 0.001 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EDN03625.1 - 0.00073 19.6 0.0 0.0026 17.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDN03625.1 - 0.0018 18.6 0.0 0.0034 17.7 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 EDN03625.1 - 0.0026 18.3 0.0 0.0051 17.3 0.1 1.6 1 1 0 1 1 1 1 ABC transporter TsaE PF02367.17 EDN03625.1 - 0.0034 17.4 0.0 0.0056 16.7 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EDN03625.1 - 0.0034 16.6 0.0 0.0065 15.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ATP_bind_2 PF03668.15 EDN03625.1 - 0.0039 16.5 0.1 0.16 11.2 0.0 2.1 2 0 0 2 2 2 1 P-loop ATPase protein family RuvB_N PF05496.12 EDN03625.1 - 0.0039 17.0 0.0 0.0068 16.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EDN03625.1 - 0.0051 16.5 0.0 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 EDN03625.1 - 0.0074 16.0 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 EDN03625.1 - 0.0078 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EDN03625.1 - 0.0081 16.4 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDN03625.1 - 0.0097 15.8 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Cytidylate_kin2 PF13189.6 EDN03625.1 - 0.0098 16.0 0.1 0.035 14.2 0.0 1.8 2 0 0 2 2 2 1 Cytidylate kinase-like family APS_kinase PF01583.20 EDN03625.1 - 0.012 15.6 0.1 0.058 13.3 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase NTPase_1 PF03266.15 EDN03625.1 - 0.012 15.5 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.12 EDN03625.1 - 0.021 14.1 0.1 0.34 10.2 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.16 EDN03625.1 - 0.021 14.3 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 EDN03625.1 - 0.021 14.3 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ADK PF00406.22 EDN03625.1 - 0.023 14.8 0.1 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Adenylate kinase AAA_25 PF13481.6 EDN03625.1 - 0.028 14.0 0.1 0.58 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDN03625.1 - 0.03 13.4 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DNA_pol3_delta2 PF13177.6 EDN03625.1 - 0.031 14.0 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_24 PF13479.6 EDN03625.1 - 0.04 13.7 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain CoaE PF01121.20 EDN03625.1 - 0.047 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase Viral_helicase1 PF01443.18 EDN03625.1 - 0.048 13.4 0.0 0.09 12.5 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EDN03625.1 - 0.051 13.0 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 EDN03625.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_6 PF12774.7 EDN03625.1 - 0.12 11.4 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_19 PF13245.6 EDN03625.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EDN03625.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PduV-EutP PF10662.9 EDN03625.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 EDN03625.1 - 0.23 12.0 0.0 0.51 10.8 0.0 1.5 2 0 0 2 2 1 0 AAA domain 2-oxoacid_dh PF00198.23 EDN03626.1 - 1.1e-78 263.9 0.1 1.5e-78 263.4 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDN03626.1 - 3.3e-13 49.3 0.0 7e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDN03626.1 - 8e-13 48.5 0.2 2.2e-12 47.1 0.2 1.8 1 0 0 1 1 1 1 e3 binding domain Cid2 PF09774.9 EDN03627.1 - 1.4e-54 184.9 0.0 1.6e-54 184.7 0.0 1.0 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Fapy_DNA_glyco PF01149.24 EDN03628.1 - 3.2e-35 121.2 0.8 5.2e-35 120.6 0.0 1.7 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EDN03628.1 - 9.9e-21 73.5 0.0 1.8e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 EDN03628.1 - 0.015 14.1 0.0 0.024 13.4 0.0 1.3 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF2263 PF10021.9 EDN03629.1 - 2.2e-17 63.8 0.0 7.5e-17 62.1 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Fe_hyd_lg_C PF02906.14 EDN03630.1 - 5.9e-50 170.2 0.0 2.9e-49 167.9 0.0 2.3 2 1 0 2 2 2 1 Iron only hydrogenase large subunit, C-terminal domain DNA_RNApol_7kD PF03604.13 EDN03631.1 - 9.1e-17 60.4 7.2 1.3e-16 60.0 7.2 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf_UBZ PF18439.1 EDN03631.1 - 0.00053 19.5 1.3 0.43 10.2 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger HypA PF01155.19 EDN03631.1 - 0.0015 18.5 0.3 0.0015 18.5 0.3 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 EDN03631.1 - 0.0019 18.3 0.3 0.002 18.2 0.3 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) Zn-ribbon_8 PF09723.10 EDN03631.1 - 0.004 17.2 1.1 0.0071 16.4 1.1 1.4 1 0 0 1 1 1 1 Zinc ribbon domain DUF2197 PF09963.9 EDN03631.1 - 0.0044 17.2 2.1 0.27 11.5 0.1 2.2 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2197) zinc-ribbon_6 PF10005.9 EDN03631.1 - 0.0051 17.5 0.4 0.0064 17.1 0.4 1.2 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EDN03631.1 - 0.0074 16.3 0.5 0.0098 15.9 0.5 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc-ribbons_6 PF07191.12 EDN03631.1 - 0.012 15.5 0.5 0.018 15.0 0.5 1.3 1 0 0 1 1 1 0 zinc-ribbons zinc_ribbon_10 PF10058.9 EDN03631.1 - 0.023 14.4 0.2 0.48 10.2 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF3268 PF11672.8 EDN03631.1 - 0.034 14.5 1.6 0.11 12.9 1.6 1.8 1 1 0 1 1 1 0 zinc-finger-containing domain DUF1451 PF07295.11 EDN03631.1 - 0.064 13.3 0.6 0.08 13.0 0.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Zn_ribbon_SprT PF17283.2 EDN03631.1 - 0.066 13.1 2.9 0.11 12.4 2.9 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain A2L_zn_ribbon PF08792.10 EDN03631.1 - 0.076 12.8 1.4 2.1 8.2 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF2757 PF10955.8 EDN03631.1 - 0.095 13.0 1.3 0.15 12.4 1.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2757) TFIIS_C PF01096.18 EDN03631.1 - 0.23 11.4 4.2 6.9 6.6 0.6 2.6 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_ribbon_recom PF13408.6 EDN03631.1 - 0.29 11.7 7.2 2.3 8.8 1.1 2.3 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain TF_Zn_Ribbon PF08271.12 EDN03631.1 - 0.31 10.6 5.2 6.1 6.4 0.7 2.2 1 1 0 2 2 2 0 TFIIB zinc-binding Rubredoxin_2 PF18073.1 EDN03631.1 - 0.35 10.6 3.5 4.1 7.2 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain Glycos_transf_3 PF00591.21 EDN03632.1 - 1.9e-58 198.0 0.0 2.2e-47 161.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EDN03632.1 - 5.7e-09 35.7 0.2 1e-08 34.9 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain PI-PLC-X PF00388.19 EDN03633.1 - 3.7e-05 23.3 0.0 7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain NARP1 PF12569.8 EDN03634.1 - 1.3e-219 730.5 15.7 1.6e-217 723.6 13.4 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EDN03634.1 - 1.7e-22 77.6 30.1 2.5e-05 24.1 0.3 11.4 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDN03634.1 - 8.3e-17 61.5 25.1 0.012 16.1 0.1 7.4 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDN03634.1 - 1.9e-16 59.3 24.9 0.014 16.1 0.1 10.6 9 3 3 12 12 11 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDN03634.1 - 2.1e-13 50.6 28.7 0.0023 18.5 2.2 8.9 8 1 2 10 10 10 4 Tetratricopeptide repeat TPR_1 PF00515.28 EDN03634.1 - 1.4e-12 46.9 24.7 4.6e-05 23.0 0.4 9.0 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDN03634.1 - 4.4e-11 42.1 30.5 0.00017 21.5 0.4 8.9 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDN03634.1 - 1.8e-09 37.1 17.5 3.5e-06 26.6 1.0 6.0 6 0 0 6 6 6 3 TPR repeat TPR_9 PF13371.6 EDN03634.1 - 8.8e-09 35.4 11.1 0.0013 18.9 0.8 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN03634.1 - 8.9e-09 35.5 17.4 0.005 17.0 1.5 5.4 4 1 0 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDN03634.1 - 3.7e-06 27.0 13.7 1.8 9.1 0.0 8.4 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_21 PF09976.9 EDN03634.1 - 5.7e-05 22.9 0.2 5.7e-05 22.9 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 EDN03634.1 - 8.2e-05 22.8 35.2 0.018 15.3 0.6 8.0 8 2 2 10 10 8 4 Tetratricopeptide repeat TPR_4 PF07721.14 EDN03634.1 - 0.00056 20.3 12.5 0.31 11.8 0.7 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat BTAD PF03704.17 EDN03634.1 - 0.0033 17.9 2.0 0.0033 17.9 2.0 3.4 2 1 1 3 3 3 1 Bacterial transcriptional activator domain TPR_6 PF13174.6 EDN03634.1 - 0.0048 17.4 18.1 2.1 9.2 0.2 7.6 8 0 0 8 8 6 2 Tetratricopeptide repeat YcaO_C PF18381.1 EDN03634.1 - 0.038 13.9 1.5 0.1 12.5 0.2 2.4 2 0 0 2 2 2 0 YcaO cyclodehydratase C-terminal domain Sel1 PF08238.12 EDN03634.1 - 0.15 12.8 1.2 4.8 8.0 0.1 3.6 4 0 0 4 4 3 0 Sel1 repeat TPR_5 PF12688.7 EDN03634.1 - 0.35 11.1 5.5 1.9 8.7 0.0 3.9 4 0 0 4 4 4 0 Tetratrico peptide repeat TPR_7 PF13176.6 EDN03634.1 - 0.45 10.7 26.0 0.99 9.6 0.2 7.4 10 0 0 10 10 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDN03634.1 - 1.6 8.7 28.1 11 6.0 0.0 8.3 9 0 0 9 9 9 0 Tetratricopeptide repeat MIT PF04212.18 EDN03634.1 - 8.1 6.6 12.3 0.97 9.5 0.5 5.1 5 1 1 6 6 5 0 MIT (microtubule interacting and transport) domain Tim54 PF11711.8 EDN03635.1 - 1.3e-77 261.2 12.8 4.7e-61 206.6 7.2 3.1 2 1 0 2 2 2 2 Inner membrane protein import complex subunit Tim54 Glu_synthase PF01645.17 EDN03635.1 - 2.3e-11 43.5 0.0 3.7e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Pkinase PF00069.25 EDN03636.1 - 2e-51 174.9 0.0 3.6e-50 170.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03636.1 - 1e-21 77.4 0.6 4.3e-16 59.0 0.1 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN03636.1 - 0.00017 20.6 0.0 0.00025 20.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDN03636.1 - 0.00025 21.1 0.3 0.06 13.3 0.3 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN03636.1 - 0.011 15.1 1.5 0.016 14.5 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 EDN03636.1 - 0.021 13.9 0.1 0.033 13.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 EDN03636.1 - 0.027 14.1 0.3 3.8 7.1 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EDN03636.1 - 0.036 12.9 0.0 0.06 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EDN03636.1 - 0.045 13.1 0.1 0.11 11.9 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EDN03636.1 - 0.086 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PA28_alpha PF02251.18 EDN03636.1 - 0.098 12.7 0.4 1.3 9.1 0.0 2.7 3 0 0 3 3 3 0 Proteasome activator pa28 alpha subunit SF3A2 PF16835.5 EDN03637.1 - 2.9e-20 72.4 0.0 4.7e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EDN03637.1 - 1.1e-05 25.7 0.5 2.3e-05 24.6 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 EDN03637.1 - 0.069 12.7 1.5 0.12 11.9 1.5 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like zf-U1 PF06220.12 EDN03637.1 - 0.78 9.6 2.5 1.8 8.4 0.2 2.3 2 0 0 2 2 2 0 U1 zinc finger CAP_GLY PF01302.25 EDN03638.1 - 3.3e-18 65.5 0.4 5.5e-18 64.8 0.4 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EDN03638.1 - 3.3e-08 33.7 1.8 0.57 10.7 0.0 4.4 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDN03638.1 - 6.9e-06 25.7 1.7 0.083 13.0 0.1 4.9 5 0 0 5 5 5 2 Leucine Rich repeat LRR_8 PF13855.6 EDN03638.1 - 5.9e-05 22.8 5.8 0.13 12.1 0.6 4.4 4 1 0 4 4 4 2 Leucine rich repeat LRR_9 PF14580.6 EDN03638.1 - 0.0018 17.8 0.1 0.97 8.9 0.0 2.8 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EDN03638.1 - 0.0058 17.0 3.4 21 6.2 0.1 5.3 3 2 0 3 3 3 1 Leucine Rich Repeat GIDE PF12483.8 EDN03638.1 - 0.11 11.9 0.2 0.21 11.0 0.2 1.4 1 0 0 1 1 1 0 E3 Ubiquitin ligase DDE_1 PF03184.19 EDN03639.1 - 1.1e-19 70.7 0.1 1.3e-11 44.4 0.0 2.5 2 1 1 3 3 3 2 DDE superfamily endonuclease zf-CCHC_4 PF14392.6 EDN03639.1 - 0.024 14.4 0.6 0.045 13.5 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EDN03639.1 - 0.043 13.9 0.6 0.085 13.0 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle HTH_Tnp_Tc5 PF03221.16 EDN03639.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain zf-CCHC_6 PF15288.6 EDN03639.1 - 0.14 12.0 1.4 0.28 11.0 1.4 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF2110 PF09883.9 EDN03639.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) ThrE_2 PF12821.7 EDN03639.1 - 0.19 11.9 0.0 0.73 10.0 0.0 1.9 2 0 0 2 2 2 0 Threonine/Serine exporter, ThrE TFIIA PF03153.13 EDN03640.1 - 0.24 11.3 10.9 0.38 10.7 10.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 EDN03640.1 - 1.3 7.4 21.3 1.8 6.9 21.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein ECM1 PF05782.11 EDN03640.1 - 6.1 5.7 12.6 8.9 5.1 12.6 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Hid1 PF12722.7 EDN03640.1 - 7.5 4.5 9.1 10 4.1 9.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA PF00004.29 EDN03641.1 - 3.3e-17 63.1 0.0 7.6e-17 62.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN03641.1 - 0.00045 20.6 0.1 0.0017 18.8 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDN03641.1 - 0.0012 18.8 0.0 0.0033 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN03641.1 - 0.0051 17.1 0.6 0.13 12.5 0.0 2.9 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 EDN03641.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDN03641.1 - 0.062 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EDN03641.1 - 0.09 13.2 0.0 0.34 11.3 0.0 2.0 2 0 0 2 2 2 0 RNA helicase DUF2205 PF10224.9 EDN03643.1 - 5e-30 103.3 0.3 7.9e-30 102.7 0.3 1.3 1 0 0 1 1 1 1 Short coiled-coil protein FRB_dom PF08771.11 EDN03643.1 - 0.035 14.5 0.1 0.067 13.6 0.1 1.4 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain GP57 PF17594.2 EDN03643.1 - 0.068 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Phage Tail fiber assembly helper gene product 57 Cytochrom_B562 PF07361.11 EDN03643.1 - 0.075 13.7 0.1 0.12 13.0 0.1 1.4 1 0 0 1 1 1 0 Cytochrome b562 FUSC PF04632.12 EDN03643.1 - 0.14 10.7 1.1 0.18 10.3 1.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Stathmin PF00836.19 EDN03643.1 - 0.22 11.5 2.0 0.33 10.9 0.5 1.8 2 0 0 2 2 2 0 Stathmin family DDE_1 PF03184.19 EDN03645.1 - 8.6e-27 93.9 0.0 1.9e-26 92.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN03645.1 - 0.00076 19.3 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN03647.1 - 3.7e-05 23.5 0.4 0.00014 21.6 0.4 1.9 1 0 0 1 1 1 1 DDE superfamily endonuclease CxC7 PF18866.1 EDN03647.1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 CxC7 like cysteine cluster associated with KDZ transposases DUF4124 PF13511.6 EDN03647.1 - 6.4 7.2 7.0 6.8 7.1 2.1 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4124) HTH_29 PF13551.6 EDN03648.1 - 0.055 13.5 0.0 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 Winged helix-turn helix DUF3435 PF11917.8 EDN03649.1 - 2.4e-151 504.4 1.3 3.1e-151 504.0 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DUF896 PF05979.12 EDN03649.1 - 0.21 11.5 2.9 11 6.0 0.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) zf-U1 PF06220.12 EDN03650.1 - 4.2e-08 32.8 0.7 6.7e-08 32.2 0.7 1.3 1 0 0 1 1 1 1 U1 zinc finger DUF1033 PF06279.11 EDN03650.1 - 0.045 13.9 0.2 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1033) ABC_tran_Xtn PF12848.7 EDN03650.1 - 0.053 13.6 2.2 0.2 11.7 1.1 2.2 2 0 0 2 2 2 0 ABC transporter Zn_clus PF00172.18 EDN03651.1 - 1.5e-08 34.6 10.5 2.6e-08 33.8 10.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EDN03651.1 - 6.2 6.7 11.7 14 5.6 11.7 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 2-Hacid_dh_C PF02826.19 EDN03652.1 - 9.9e-54 181.4 0.0 1.3e-53 181.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN03652.1 - 6.7e-14 51.7 0.0 8.5e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDN03652.1 - 0.00098 19.3 0.0 0.0016 18.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EDN03652.1 - 0.029 14.0 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain CwfJ_C_1 PF04677.15 EDN03653.1 - 1.5e-31 108.8 0.0 4.4e-31 107.3 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EDN03653.1 - 1.1e-28 100.0 0.1 1.1e-28 100.0 0.1 2.3 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 DUF3010 PF11215.8 EDN03653.1 - 0.29 11.5 2.7 3.1 8.1 0.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3010) ATP_bind_1 PF03029.17 EDN03654.1 - 6.6e-64 216.0 0.0 1.3e-63 215.0 0.0 1.5 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EDN03654.1 - 3.7e-05 22.9 0.2 0.0044 16.1 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EDN03654.1 - 0.00028 20.5 0.0 0.017 14.7 0.0 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EDN03654.1 - 0.00065 19.3 0.0 0.04 13.5 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EDN03654.1 - 0.00089 19.3 0.0 0.016 15.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EDN03654.1 - 0.0014 18.4 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 EDN03654.1 - 0.002 17.6 0.0 3.8 6.9 0.0 3.1 2 1 0 2 2 2 2 ADP-ribosylation factor family NACHT PF05729.12 EDN03654.1 - 0.0035 17.3 0.0 0.025 14.5 0.0 2.1 2 0 0 2 2 2 1 NACHT domain PRK PF00485.18 EDN03654.1 - 0.0044 16.8 0.0 0.033 13.9 0.0 2.0 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EDN03654.1 - 0.005 16.1 0.1 0.017 14.3 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 EDN03654.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDN03654.1 - 0.019 15.2 0.0 0.076 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EDN03654.1 - 0.022 13.9 0.1 0.71 9.0 0.0 2.5 2 1 0 2 2 2 0 G-protein alpha subunit SRP54 PF00448.22 EDN03654.1 - 0.022 14.4 0.0 0.29 10.7 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EDN03654.1 - 0.023 15.1 0.0 0.055 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EDN03654.1 - 0.03 14.1 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EDN03654.1 - 0.032 14.4 0.0 3.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Thymidylate_kin PF02223.17 EDN03654.1 - 0.033 13.8 0.0 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase cobW PF02492.19 EDN03654.1 - 0.059 13.0 0.1 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EDN03654.1 - 0.16 11.7 0.1 2.7 7.8 0.0 2.7 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF1471 PF07338.13 EDN03656.1 - 0.16 12.0 0.5 0.63 10.1 0.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) TFIIA PF03153.13 EDN03656.1 - 4 7.3 10.7 4.2 7.3 5.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SUZ PF12752.7 EDN03657.1 - 0.00024 21.8 7.5 0.00024 21.8 7.5 2.8 2 1 0 2 2 2 1 SUZ domain eIF3_subunit PF08597.10 EDN03657.1 - 0.027 14.4 5.0 0.26 11.2 0.9 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DUF1661 PF07877.11 EDN03659.1 - 1 9.1 5.2 8.3 6.2 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1661) Aldo_ket_red PF00248.21 EDN03660.1 - 4.9e-09 35.8 0.2 8.4e-08 31.7 0.0 2.2 1 1 1 2 2 2 2 Aldo/keto reductase family F-box-like PF12937.7 EDN03662.1 - 0.00014 21.6 0.5 0.00065 19.5 0.2 2.4 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EDN03662.1 - 0.18 12.3 5.2 4.2 7.9 0.0 4.4 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) BSD PF03909.17 EDN03663.1 - 5.6e-28 96.7 15.4 1.5e-14 53.7 0.4 3.3 4 0 0 4 4 4 2 BSD domain PH_TFIIH PF08567.11 EDN03663.1 - 2.8e-19 69.2 0.0 7.6e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain Pyr_redox_3 PF13738.6 EDN03663.1 - 0.15 11.3 0.3 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HTH_Tnp_Tc5 PF03221.16 EDN03664.1 - 1.9e-07 31.0 0.0 3.7e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EDN03664.1 - 6.8e-07 29.1 0.1 3.9e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease Nucleo_P87 PF07267.11 EDN03665.1 - 0.026 13.4 2.4 0.032 13.1 2.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NOA36 PF06524.12 EDN03665.1 - 1.2 8.4 3.4 1.5 8.1 3.4 1.1 1 0 0 1 1 1 0 NOA36 protein HTH_7 PF02796.15 EDN03666.1 - 7.6e-06 25.9 0.0 6.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 EDN03666.1 - 2e-05 24.5 0.1 0.00023 21.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 EDN03666.1 - 2.1e-05 24.2 0.1 0.0011 18.7 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 EDN03666.1 - 5.5e-05 22.9 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_33 PF13592.6 EDN03666.1 - 0.00013 21.5 0.0 0.00048 19.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix PAX PF00292.18 EDN03666.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.4 1 1 0 1 1 1 0 'Paired box' domain Terminase_5 PF06056.12 EDN03666.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_32 PF13565.6 EDN03666.1 - 0.099 13.3 0.0 4.8 7.9 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.6 EDN03666.1 - 0.17 12.0 0.1 19 5.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain C4bp_oligo PF18453.1 EDN03667.1 - 0.88 9.8 3.4 1.3 9.3 0.6 2.5 3 0 0 3 3 3 0 Oligomerization domain of C4b-binding protein alpha DUF1751 PF08551.10 EDN03668.1 - 0.049 14.2 0.2 0.12 13.0 0.1 1.7 1 1 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) PHD PF00628.29 EDN03669.1 - 1.8e-06 27.7 8.1 2.8e-06 27.1 8.1 1.3 1 0 0 1 1 1 1 PHD-finger ING PF12998.7 EDN03669.1 - 0.0011 19.5 0.0 0.0022 18.6 0.0 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H PF13771.6 EDN03669.1 - 0.014 15.6 1.7 0.028 14.7 1.7 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EDN03669.1 - 0.2 11.9 1.0 0.36 11.0 1.0 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain PHD_2 PF13831.6 EDN03669.1 - 0.74 9.4 3.0 1.4 8.5 3.0 1.4 1 0 0 1 1 1 0 PHD-finger Transket_pyr PF02779.24 EDN03670.1 - 3.3e-65 219.1 0.0 5.4e-65 218.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EDN03670.1 - 9e-58 194.3 0.0 1.5e-57 193.5 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EDN03670.1 - 1.1e-51 175.5 0.0 1.7e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 EDN03670.1 - 1.4e-20 72.6 2.5 1.5e-20 72.5 0.6 2.2 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus PNTB PF02233.16 EDN03671.1 - 2.6e-45 155.2 0.3 3e-45 155.0 0.3 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit Sld5 PF05916.11 EDN03675.1 - 6.7e-14 52.3 0.0 1.2e-13 51.5 0.0 1.4 1 1 0 1 1 1 1 GINS complex protein Cnn_1N PF07989.11 EDN03677.1 - 4.6e-07 29.9 14.0 2.4e-06 27.6 14.0 2.2 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 AAA_23 PF13476.6 EDN03677.1 - 0.06 13.9 5.1 0.14 12.6 5.1 1.6 1 0 0 1 1 1 0 AAA domain Prominin PF05478.11 EDN03677.1 - 0.69 7.8 5.3 1.1 7.2 5.3 1.1 1 0 0 1 1 1 0 Prominin DUF724 PF05266.14 EDN03677.1 - 0.77 9.6 6.9 1.5 8.7 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Tropomyosin_1 PF12718.7 EDN03677.1 - 1.1 9.4 15.4 2.4 8.3 15.4 1.5 1 0 0 1 1 1 0 Tropomyosin like FlaC_arch PF05377.11 EDN03677.1 - 1.7 9.1 3.8 8 6.9 3.8 2.2 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) YabA PF06156.13 EDN03677.1 - 3.9 8.2 10.1 2.5 8.8 6.8 2.3 2 1 0 2 2 2 0 Initiation control protein YabA Sod_Fe_C PF02777.18 EDN03678.1 - 5.5e-37 126.0 0.3 5.5e-37 126.0 0.3 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDN03678.1 - 3.5e-29 101.1 2.1 5.5e-29 100.5 2.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF2921 PF11145.8 EDN03678.1 - 0.21 9.4 0.2 3.8 5.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2921) GCFC PF07842.12 EDN03679.1 - 2.4e-91 306.2 5.4 2.4e-91 306.2 5.4 1.4 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EDN03679.1 - 6e-14 51.7 3.0 1.2e-13 50.7 3.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDN03679.1 - 3.2e-06 27.1 1.2 3.2e-06 27.1 1.2 2.2 2 0 0 2 2 2 1 G-patch domain LGFP PF08310.11 EDN03680.1 - 0.0045 17.5 0.0 0.0059 17.1 0.0 1.1 1 0 0 1 1 1 1 LGFP repeat SHR-BD PF06650.12 EDN03681.1 - 4.3e-86 288.7 0.0 2.2e-85 286.3 0.0 1.9 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 EDN03681.1 - 5.4e-41 140.3 4.2 5.4e-36 124.0 0.7 2.7 1 1 1 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 EDN03681.1 - 3.5e-07 30.5 0.0 7.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Apt1 PF10351.9 EDN03681.1 - 0.046 12.6 0.0 0.07 12.0 0.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain VPS13_mid_rpt PF16910.5 EDN03682.1 - 2.6e-88 295.4 17.1 7e-88 294.0 0.9 5.0 5 0 0 5 5 5 2 Repeating coiled region of VPS13 VPS13 PF16908.5 EDN03682.1 - 7.6e-73 245.2 2.0 4.7e-71 239.3 0.0 3.5 4 1 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EDN03682.1 - 2e-39 134.3 0.0 7.2e-39 132.5 0.0 2.1 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Ribosomal_60s PF00428.19 EDN03682.1 - 0.034 14.7 1.5 1.5 9.5 0.4 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3429 PF11911.8 EDN03683.1 - 2.7e-44 151.0 12.4 4.5e-44 150.2 12.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) FGGY_N PF00370.21 EDN03684.1 - 2.7e-62 210.5 0.0 3.5e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EDN03684.1 - 9.4e-52 175.6 0.9 1.9e-47 161.5 0.3 2.4 1 1 1 2 2 2 2 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EDN03684.1 - 0.034 13.6 0.3 2 7.8 0.0 2.1 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Peptidase_M41 PF01434.18 EDN03685.1 - 5e-59 199.4 0.4 9.4e-59 198.5 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDN03685.1 - 2e-41 141.5 0.0 5.4e-41 140.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN03685.1 - 2.3e-10 40.1 0.0 7.7e-10 38.4 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDN03685.1 - 0.0064 16.8 1.8 1.4 9.2 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 EDN03685.1 - 0.0067 16.4 0.0 0.021 14.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN03685.1 - 0.014 15.8 0.2 0.28 11.5 0.2 2.5 1 1 0 1 1 1 0 AAA ATPase domain TIP49 PF06068.13 EDN03685.1 - 0.026 13.7 0.2 0.085 12.0 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_17 PF13207.6 EDN03685.1 - 0.039 14.4 0.2 0.35 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 EDN03685.1 - 0.056 13.6 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDN03685.1 - 0.057 13.2 0.0 0.18 11.5 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 EDN03685.1 - 0.077 12.4 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein NTP_transferase PF00483.23 EDN03687.1 - 1.2e-51 175.8 0.0 2.6e-51 174.6 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EDN03687.1 - 4.4e-15 54.7 8.8 5.1e-11 41.8 1.8 3.9 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EDN03687.1 - 3.1e-09 37.4 0.0 4.3e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EDN03687.1 - 2.6e-06 27.1 1.0 2.6e-06 27.1 1.0 3.1 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EDN03687.1 - 0.038 12.1 0.1 0.084 11.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) IspD PF01128.19 EDN03687.1 - 0.089 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase adh_short PF00106.25 EDN03688.1 - 5.8e-07 29.2 0.0 0.00021 20.8 0.0 2.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03688.1 - 0.15 11.6 0.0 6.6 6.2 0.0 2.2 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Nitrate_red_gam PF02665.14 EDN03689.1 - 0.034 13.7 0.2 0.071 12.7 0.2 1.4 1 0 0 1 1 1 0 Nitrate reductase gamma subunit TMEM51 PF15345.6 EDN03689.1 - 0.055 13.3 0.2 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 Transmembrane protein 51 Suc_Fer-like PF06999.12 EDN03691.1 - 4.5e-69 232.2 0.0 5.5e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like 2-Hacid_dh_C PF02826.19 EDN03692.1 - 1e-42 145.5 0.0 1.8e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN03692.1 - 3.7e-10 39.6 0.0 5.2e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain DUF4129 PF13559.6 EDN03693.1 - 0.016 15.5 0.0 0.062 13.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) P53_C PF11619.8 EDN03693.1 - 0.066 13.3 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain Aminotran_1_2 PF00155.21 EDN03694.1 - 1e-37 130.2 0.0 1.3e-37 129.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II CDC24 PF06395.11 EDN03696.1 - 2.7e-34 117.3 0.0 5.2e-34 116.4 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 EDN03696.1 - 3.4e-28 99.1 0.7 6.2e-28 98.3 0.7 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 EDN03696.1 - 4.1e-27 94.9 0.0 8.7e-27 93.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 EDN03696.1 - 1.4e-09 37.8 0.1 3.7e-09 36.4 0.1 1.8 1 0 0 1 1 1 1 PB1 domain YppF PF14178.6 EDN03696.1 - 0.54 10.2 1.8 7 6.6 0.4 3.2 4 0 0 4 4 4 0 YppF-like protein WD40 PF00400.32 EDN03697.1 - 3.5e-32 109.9 3.4 9.7e-06 26.2 0.1 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN03697.1 - 2.3e-05 24.6 1.3 1 9.7 0.0 4.1 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN03697.1 - 0.00017 20.4 0.5 0.68 8.5 0.0 2.9 2 1 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDN03697.1 - 0.071 12.4 0.0 18 4.5 0.0 3.1 3 1 1 4 4 4 0 WD40-like domain Uds1 PF15456.6 EDN03700.1 - 1.1e-42 145.3 2.5 1.1e-42 145.3 2.5 6.5 3 1 3 6 6 6 1 Up-regulated During Septation CK2S PF15011.6 EDN03700.1 - 0.0064 16.4 1.9 0.0064 16.4 1.9 4.0 3 0 0 3 3 3 1 Casein Kinase 2 substrate GAS PF13851.6 EDN03700.1 - 0.007 15.7 6.1 0.007 15.7 6.1 7.3 4 1 3 8 8 8 1 Growth-arrest specific micro-tubule binding Prp19 PF08606.11 EDN03700.1 - 3.3 7.8 14.5 0.3 11.1 1.0 4.3 4 0 0 4 4 4 0 Prp19/Pso4-like MFS_1 PF07690.16 EDN03702.1 - 2.8e-17 62.7 30.5 1.6e-15 56.9 30.5 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EDN03702.1 - 0.01 14.7 1.4 0.01 14.7 1.4 2.3 2 1 0 2 2 2 0 MFS_1 like family UCR_hinge PF02320.16 EDN03703.1 - 5.7e-28 96.9 8.2 5.7e-28 96.9 8.2 1.5 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein DUF4211 PF13926.6 EDN03703.1 - 0.049 13.7 1.4 0.061 13.4 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4211) DUF1940 PF09155.10 EDN03703.1 - 0.085 13.0 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) DUF3391 PF11871.8 EDN03703.1 - 0.23 12.0 4.1 0.3 11.6 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) PTPRCAP PF15713.5 EDN03703.1 - 0.32 11.3 8.9 0.32 11.3 8.9 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated GOLD_2 PF13897.6 EDN03703.1 - 0.65 10.5 2.8 0.87 10.1 2.8 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking ATHILA PF03078.15 EDN03703.1 - 1.3 7.8 5.8 1.5 7.6 5.8 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family TRAP_alpha PF03896.16 EDN03703.1 - 1.8 7.7 4.7 2.1 7.5 4.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pox_Ag35 PF03286.14 EDN03703.1 - 4.5 7.0 8.9 5 6.9 8.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 EDN03703.1 - 9.6 4.2 10.9 10 4.1 10.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi Coq4 PF05019.13 EDN03704.1 - 1.3e-96 322.2 0.0 1.6e-96 321.9 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Vps36_ESCRT-II PF11605.8 EDN03705.1 - 0.0038 17.4 0.0 0.054 13.7 0.0 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 TMEM52 PF14979.6 EDN03705.1 - 0.037 14.0 1.4 0.054 13.4 1.4 1.2 1 0 0 1 1 1 0 Transmembrane 52 GRAM PF02893.20 EDN03705.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 GRAM domain FAM180 PF15173.6 EDN03707.1 - 0.0031 17.5 0.1 0.0049 16.9 0.1 1.3 1 0 0 1 1 1 1 FAM180 family HSBP1 PF06825.12 EDN03707.1 - 0.067 13.0 0.2 0.067 13.0 0.2 1.9 2 0 0 2 2 2 0 Heat shock factor binding protein 1 FtsX_ECD PF18075.1 EDN03707.1 - 0.084 13.5 0.6 0.17 12.5 0.4 1.6 1 1 1 2 2 2 0 FtsX extracellular domain Csm1_N PF18504.1 EDN03707.1 - 1 9.8 8.1 0.38 11.1 1.4 2.7 2 1 1 3 3 3 0 Csm1 N-terminal domain FapA PF03961.13 EDN03707.1 - 1.3 7.6 3.8 1.7 7.2 3.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A KLRAQ PF10205.9 EDN03707.1 - 1.4 9.2 7.0 0.29 11.4 2.9 1.9 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Exonuc_VII_L PF02601.15 EDN03707.1 - 4.2 6.9 7.6 5.7 6.4 7.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med9 PF07544.13 EDN03707.1 - 8.5 6.5 7.7 0.6 10.2 2.2 1.9 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Acyltransferase PF01553.21 EDN03708.1 - 6.2e-09 35.6 0.7 0.0009 18.9 0.0 2.8 3 0 0 3 3 3 2 Acyltransferase DUF3710 PF12502.8 EDN03708.1 - 0.14 11.8 0.1 0.26 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3710) DPM3 PF08285.11 EDN03708.1 - 0.19 11.9 5.1 0.81 9.9 5.1 2.1 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Prenyltransf PF01255.19 EDN03709.1 - 1.1e-77 260.6 0.0 1.7e-77 259.9 0.0 1.3 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Sacchrp_dh_C PF16653.5 EDN03710.1 - 1.4e-93 313.9 0.0 2.3e-93 313.1 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EDN03710.1 - 4.7e-20 72.2 0.2 7e-20 71.6 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EDN03710.1 - 0.00065 19.6 0.3 0.001 19.0 0.3 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 EDN03710.1 - 0.0032 17.5 0.0 0.007 16.4 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Cupin_2 PF07883.11 EDN03711.1 - 5.1e-08 32.5 0.0 9.5e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EDN03711.1 - 0.0095 15.5 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Cupin DMSP_lyase PF16867.5 EDN03711.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase GMC_oxred_N PF00732.19 EDN03712.1 - 8.4e-50 169.8 0.0 4.2e-30 105.1 0.0 2.1 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN03712.1 - 1e-33 116.9 0.0 1.6e-33 116.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDN03712.1 - 2.2e-05 23.7 0.1 0.062 12.4 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EDN03712.1 - 0.00048 19.8 0.1 0.0061 16.2 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDN03712.1 - 0.0015 18.7 0.0 0.004 17.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EDN03712.1 - 0.0017 18.6 0.0 0.0036 17.6 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox_3 PF13738.6 EDN03712.1 - 0.0078 15.5 0.1 0.18 11.0 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN03712.1 - 0.076 12.2 0.0 0.34 10.1 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDN03712.1 - 0.17 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EDN03712.1 - 0.2 10.9 0.0 0.34 10.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain ADH_zinc_N_2 PF13602.6 EDN03713.1 - 2.5e-24 86.8 0.0 4.1e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDN03713.1 - 2.6e-16 59.8 0.0 4.2e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN03713.1 - 0.0017 18.2 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Fungal_trans PF04082.18 EDN03714.1 - 1.5e-09 37.3 0.1 2.4e-09 36.6 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN03714.1 - 2.3e-09 37.2 7.9 4.3e-09 36.3 7.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_15 PF00723.21 EDN03716.1 - 1.7e-61 208.4 0.0 1.7e-38 132.6 0.0 3.0 2 1 1 3 3 3 3 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EDN03716.1 - 2.1e-21 75.6 0.0 4.3e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain Alpha-amylase PF00128.24 EDN03717.1 - 1.8e-50 172.4 0.0 1.1e-25 91.0 0.2 2.1 2 0 0 2 2 2 2 Alpha amylase, catalytic domain DUF1966 PF09260.11 EDN03717.1 - 2.6e-28 98.1 0.0 4.7e-28 97.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) hDGE_amylase PF14701.6 EDN03717.1 - 0.017 14.2 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain UBA_6 PF18039.1 EDN03717.1 - 0.078 12.9 0.0 1.7 8.6 0.0 2.6 3 0 0 3 3 3 0 UBA-like domain Aha1_N PF09229.11 EDN03718.1 - 1e-41 142.3 2.8 1.5e-41 141.8 1.8 1.7 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EDN03718.1 - 1.8e-17 63.7 0.3 3.1e-17 63.0 0.3 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein V_ATPase_I PF01496.19 EDN03720.1 - 1.7e-294 978.9 6.6 1.2e-156 522.9 0.0 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family CheZ PF04344.13 EDN03720.1 - 0.014 15.3 0.3 0.056 13.4 0.1 1.9 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ DUF4988 PF16378.5 EDN03720.1 - 0.041 13.5 0.2 0.081 12.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function Filament PF00038.21 EDN03720.1 - 0.12 12.0 0.9 7.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Intermediate filament protein DUF1515 PF07439.11 EDN03720.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DASH_Dam1 PF08653.10 EDN03720.1 - 0.29 11.0 4.7 3.8 7.4 0.2 4.1 5 0 0 5 5 5 0 DASH complex subunit Dam1 BLM10_mid PF16507.5 EDN03721.1 - 8.5e-104 348.1 0.4 1.3e-81 274.9 0.1 3.3 1 1 1 2 2 2 2 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EDN03721.1 - 3.7e-28 97.3 0.0 2e-27 94.9 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EDN03721.1 - 9e-24 83.6 0.7 4.9e-23 81.2 0.0 2.5 3 0 0 3 3 3 1 Proteasome-substrate-size regulator, N-terminal HEAT PF02985.22 EDN03721.1 - 0.00093 19.3 0.1 1.9 9.0 0.1 5.3 5 0 0 5 5 5 1 HEAT repeat CLASP_N PF12348.8 EDN03721.1 - 0.0086 15.7 0.0 0.032 13.8 0.0 2.0 1 0 0 1 1 1 1 CLASP N terminal HEAT_2 PF13646.6 EDN03721.1 - 0.032 14.6 0.0 2.6 8.5 0.0 3.9 5 0 0 5 5 5 0 HEAT repeats MgtE_N PF03448.17 EDN03721.1 - 0.071 13.7 0.1 17 6.1 0.0 3.1 2 0 0 2 2 2 0 MgtE intracellular N domain Rrp40_N PF18311.1 EDN03722.1 - 0.018 15.0 0.1 0.046 13.7 0.1 1.7 1 0 0 1 1 1 0 Exosome complex exonuclease Rrp40 N-terminal domain YTH PF04146.15 EDN03723.1 - 1.1e-35 123.0 0.0 1.7e-34 119.2 0.0 2.8 1 1 0 1 1 1 1 YT521-B-like domain Pro_CA PF00484.19 EDN03724.1 - 2.2e-45 154.7 0.1 2.7e-45 154.4 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Velvet PF11754.8 EDN03725.1 - 4.6e-42 144.7 0.1 2.2e-30 106.4 0.0 4.3 3 2 1 4 4 4 2 Velvet factor MOZ_SAS PF01853.18 EDN03727.1 - 2.1e-75 252.3 0.0 3.1e-75 251.8 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDN03727.1 - 3.8e-21 74.4 3.4 8.5e-21 73.3 3.4 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 EDN03727.1 - 0.0046 17.0 2.3 0.0046 17.0 2.3 2.7 1 1 1 2 2 2 1 PHD-finger Acetyltransf_7 PF13508.7 EDN03727.1 - 0.19 12.2 0.0 0.41 11.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Nop14 PF04147.12 EDN03727.1 - 2.5 6.2 21.2 4.2 5.4 21.2 1.3 1 0 0 1 1 1 0 Nop14-like family MWFE PF15879.5 EDN03728.1 - 1.1e-27 95.9 0.5 1.7e-27 95.3 0.5 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Acetyltransf_2 PF00797.17 EDN03729.1 - 2e-16 60.5 0.0 2.4e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase RraA-like PF03737.15 EDN03730.1 - 3.6e-30 105.1 0.0 5e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA Thiolase_N PF00108.23 EDN03731.1 - 4.4e-75 252.4 4.5 7e-75 251.7 4.5 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN03731.1 - 3.1e-44 149.6 0.1 5.7e-44 148.7 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDN03731.1 - 0.0016 18.1 0.5 0.01 15.5 0.2 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain FOXO_KIX_bdg PF16675.5 EDN03732.1 - 0.055 13.8 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 KIX-binding domain of forkhead box O, CR2 MFS_1 PF07690.16 EDN03733.1 - 6.6e-13 48.3 20.1 2.5e-11 43.1 12.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Drf_GBD PF06371.13 EDN03734.1 - 1.5e-18 67.0 0.9 3.2e-11 43.1 0.0 2.5 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain Snf7 PF03357.21 EDN03735.1 - 1.7e-39 135.1 12.5 2.5e-39 134.6 12.5 1.2 1 0 0 1 1 1 1 Snf7 Zwint PF15556.6 EDN03735.1 - 0.0034 16.9 5.6 0.0049 16.4 5.6 1.3 1 0 0 1 1 1 1 ZW10 interactor DUF848 PF05852.11 EDN03735.1 - 0.073 13.2 3.6 0.14 12.3 3.6 1.5 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4201 PF13870.6 EDN03735.1 - 0.086 12.6 9.4 0.063 13.0 6.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) HHH_2 PF12826.7 EDN03735.1 - 0.18 11.9 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF4208 PF13907.6 EDN03735.1 - 0.25 11.8 2.4 0.32 11.5 0.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4208) SAPS PF04499.15 EDN03736.1 - 3.5e-177 590.1 0.1 2.8e-176 587.1 0.0 2.0 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein Complex1_51K PF01512.17 EDN03738.1 - 2.4e-47 160.6 0.0 3.7e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EDN03738.1 - 1.6e-29 101.8 1.6 4.8e-29 100.3 0.4 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EDN03738.1 - 1.5e-09 37.6 0.0 5e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 SLBB domain DUF3568 PF12092.8 EDN03738.1 - 0.12 12.5 0.4 0.21 11.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) Nup96 PF12110.8 EDN03739.1 - 2.1e-78 263.4 0.0 3.2e-78 262.8 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EDN03739.1 - 8.4e-49 165.5 0.0 1.6e-48 164.6 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase TFIIF_alpha PF05793.12 EDN03739.1 - 2.8 6.4 12.2 6 5.3 12.2 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AMP-binding PF00501.28 EDN03741.1 - 2.9e-89 299.6 0.0 3.8e-89 299.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN03741.1 - 3.8e-28 98.3 0.2 9.5e-26 90.6 0.2 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EDN03741.1 - 6.2e-19 67.7 0.0 1.5e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus DUF1967 PF09269.11 EDN03741.1 - 0.031 14.2 0.1 2.4 8.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) GET2 PF08690.10 EDN03743.1 - 9.5e-13 48.5 0.0 3.1e-12 46.8 0.0 1.7 1 1 0 1 1 1 1 GET complex subunit GET2 DUF3094 PF11293.8 EDN03743.1 - 0.086 12.6 0.2 0.23 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF3292 PF11696.8 EDN03743.1 - 2.8 6.2 3.8 3.9 5.7 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) C2 PF00168.30 EDN03744.1 - 8.3e-29 99.9 0.0 4.8e-17 62.1 0.0 2.7 2 0 0 2 2 2 2 C2 domain Hepcidin PF06446.12 EDN03744.1 - 0.24 11.8 0.4 1 9.8 0.0 2.2 2 0 0 2 2 2 0 Hepcidin Tmemb_cc2 PF10267.9 EDN03744.1 - 0.84 8.7 5.2 1.8 7.6 5.2 1.5 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein U1snRNP70_N PF12220.8 EDN03744.1 - 8.5 7.1 12.1 7.3 7.3 3.6 3.3 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PFL-like PF02901.15 EDN03746.1 - 0.0028 16.4 1.5 0.0028 16.4 1.5 1.4 1 1 0 1 1 1 1 Pyruvate formate lyase-like DUF3746 PF12562.8 EDN03746.1 - 0.0042 17.0 0.8 0.009 15.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3746) HalX PF08663.10 EDN03746.1 - 0.33 11.3 6.8 4.2 7.8 0.4 2.7 2 1 1 3 3 3 0 HalX domain DUF3435 PF11917.8 EDN03747.1 - 7.7e-168 558.7 0.4 1e-167 558.3 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN03747.1 - 2.2e-05 24.3 0.1 0.0032 17.3 0.0 2.5 2 0 0 2 2 2 2 Phage integrase family Pkinase_fungal PF17667.1 EDN03748.1 - 1e-126 423.0 0.0 1.2e-126 422.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase DCD PF06559.11 EDN03748.1 - 0.16 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Lac_bphage_repr PF06543.12 EDN03749.1 - 1.2 9.2 4.7 0.54 10.3 2.2 1.7 2 0 0 2 2 2 0 Lactococcus bacteriophage repressor Piwi PF02171.17 EDN03752.1 - 1e-69 235.1 0.0 1.7e-69 234.4 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EDN03752.1 - 3e-18 66.7 0.0 5.9e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EDN03752.1 - 4.6e-16 58.2 0.2 1.1e-15 57.0 0.2 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EDN03752.1 - 2.4e-10 40.6 0.0 5.7e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EDN03752.1 - 0.00097 19.0 0.1 0.0021 17.9 0.1 1.6 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EDN03752.1 - 0.0023 18.2 0.0 0.0057 16.9 0.0 1.7 1 0 0 1 1 1 1 Mid domain of argonaute APH PF01636.23 EDN03754.1 - 1.4e-08 35.0 0.0 2.2e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN03754.1 - 0.0055 16.1 0.0 0.02 14.2 0.0 1.8 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 EDN03754.1 - 0.023 14.3 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EDN03754.1 - 0.18 10.6 0.0 0.49 9.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 EDN03754.1 - 0.22 10.9 0.0 3 7.1 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain APH PF01636.23 EDN03755.1 - 0.014 15.3 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDN03755.1 - 0.084 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain AAA PF00004.29 EDN03757.1 - 9.7e-15 55.2 0.0 1.4e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN03757.1 - 0.0022 18.4 0.2 0.061 13.7 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDN03757.1 - 0.0071 16.1 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EDN03757.1 - 0.051 13.1 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDN03757.1 - 0.12 12.7 0.2 2.4 8.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN03757.1 - 0.15 12.1 0.1 0.7 9.9 0.0 2.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) EAR PF07897.11 EDN03757.1 - 0.16 11.6 0.1 0.38 10.4 0.1 1.6 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression TPR_12 PF13424.6 EDN03758.1 - 6.5e-06 26.3 0.7 0.11 12.8 0.1 3.9 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_5 PF12688.7 EDN03758.1 - 0.029 14.6 0.2 0.37 11.1 0.1 2.5 2 0 0 2 2 2 0 Tetratrico peptide repeat TPR_2 PF07719.17 EDN03758.1 - 0.032 14.3 0.1 40 4.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDN03758.1 - 0.045 14.3 0.1 0.23 12.0 0.1 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDN03758.1 - 0.14 12.8 0.0 1.9 9.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDN03758.1 - 0.15 12.1 0.3 24 5.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat BCS1_N PF08740.11 EDN03759.1 - 1.4e-35 122.9 0.0 2.5e-35 122.2 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN03759.1 - 1.3e-18 67.7 0.0 3.5e-18 66.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN03759.1 - 0.0002 21.8 0.0 0.00047 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDN03759.1 - 0.017 15.6 1.1 2.6 8.6 0.1 3.4 2 1 1 3 3 3 0 AAA domain PPV_E1_C PF00519.17 EDN03759.1 - 0.046 12.6 0.0 0.085 11.7 0.0 1.4 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 EDN03759.1 - 0.066 12.9 0.0 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN03759.1 - 0.068 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EDN03759.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EDN03759.1 - 0.071 12.7 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EDN03759.1 - 0.097 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 EDN03759.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Myb_DNA-binding PF00249.31 EDN03760.1 - 1.7e-13 50.5 0.7 8.3e-12 45.1 0.0 2.6 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN03760.1 - 1.4e-06 28.4 0.5 1.5e-05 25.1 0.0 2.4 1 1 1 2 2 2 1 Myb-like DNA-binding domain AGOG PF09171.10 EDN03760.1 - 0.026 13.8 0.1 0.037 13.4 0.1 1.1 1 0 0 1 1 1 0 N-glycosylase/DNA lyase TIR PF01582.20 EDN03760.1 - 0.038 13.8 0.5 0.049 13.4 0.5 1.2 1 0 0 1 1 1 0 TIR domain Spexin PF15171.6 EDN03761.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Neuropeptide secretory protein family, NPQ, spexin DegS PF05384.11 EDN03761.1 - 0.11 11.9 0.3 0.3 10.6 0.1 1.7 2 0 0 2 2 2 0 Sensor protein DegS Trimer_CC PF08954.11 EDN03761.1 - 1.9 8.1 7.4 1.9 8.1 3.2 2.9 3 0 0 3 3 3 0 Trimerisation motif Myb_DNA-binding PF00249.31 EDN03762.1 - 0.0024 18.0 0.2 0.0053 16.9 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4244 PF14029.6 EDN03762.1 - 0.18 11.3 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) TFIIF_alpha PF05793.12 EDN03764.1 - 0.022 13.3 11.3 0.023 13.3 11.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EDN03764.1 - 0.048 11.9 8.5 0.049 11.9 8.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1682 PF07946.14 EDN03764.1 - 0.062 12.5 6.5 0.095 11.9 6.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) NOA36 PF06524.12 EDN03764.1 - 0.08 12.2 4.8 0.089 12.1 4.8 1.2 1 0 0 1 1 1 0 NOA36 protein Ribosomal_60s PF00428.19 EDN03764.1 - 0.085 13.5 12.7 0.17 12.5 12.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein FmiP_Thoc5 PF09766.9 EDN03764.1 - 0.094 12.0 5.6 0.14 11.5 5.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DDHD PF02862.17 EDN03764.1 - 0.11 12.6 1.9 0.12 12.5 1.9 1.2 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 EDN03764.1 - 0.15 11.0 2.2 0.15 11.0 2.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 EDN03764.1 - 0.19 11.5 1.7 0.27 11.0 1.7 1.3 1 0 0 1 1 1 0 Connexin SelP_N PF04592.14 EDN03764.1 - 0.2 11.0 2.9 0.31 10.4 2.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region VIT1 PF01988.19 EDN03764.1 - 0.31 10.9 4.1 0.43 10.4 4.1 1.2 1 0 0 1 1 1 0 VIT family TRAP_alpha PF03896.16 EDN03764.1 - 0.65 9.2 4.6 0.84 8.8 4.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nucleo_P87 PF07267.11 EDN03764.1 - 0.69 8.7 6.0 0.71 8.7 6.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MCM_bind PF09739.9 EDN03764.1 - 0.76 8.1 3.7 1 7.7 3.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ferlin_C PF16165.5 EDN03764.1 - 1.1 9.2 5.2 2 8.3 5.2 1.5 1 0 0 1 1 1 0 Ferlin C-terminus Rrn6 PF10214.9 EDN03764.1 - 1.2 7.5 6.9 1.7 7.0 6.9 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Presenilin PF01080.17 EDN03764.1 - 1.3 7.7 7.3 1.3 7.7 7.3 1.2 1 0 0 1 1 1 0 Presenilin Paf1 PF03985.13 EDN03764.1 - 1.8 7.5 16.4 2.4 7.1 16.4 1.1 1 0 0 1 1 1 0 Paf1 RR_TM4-6 PF06459.12 EDN03764.1 - 2.5 7.9 14.4 3.1 7.6 14.4 1.2 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 EDN03764.1 - 2.9 7.0 3.4 4 6.6 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 EDN03764.1 - 3 6.7 3.7 4 6.3 3.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) NPR3 PF03666.13 EDN03764.1 - 3.2 6.4 6.2 4 6.1 6.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4746 PF15928.5 EDN03764.1 - 4.2 6.7 12.5 6.8 6.0 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PAC1 PF16094.5 EDN03764.1 - 4.3 6.4 8.8 6.6 5.8 8.8 1.3 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 CDC45 PF02724.14 EDN03764.1 - 5.7 5.1 13.1 8.1 4.6 13.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 EDN03764.1 - 6.5 6.2 6.3 11 5.5 6.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 RPN2_C PF18004.1 EDN03764.1 - 8.8 6.2 12.5 14 5.6 12.5 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2841 PF11001.8 EDN03767.1 - 9.6e-46 154.9 0.2 1.4e-45 154.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) AAA_assoc PF14363.6 EDN03769.1 - 0.0052 17.1 0.1 0.0083 16.4 0.1 1.3 1 0 0 1 1 1 1 Domain associated at C-terminal with AAA RVT_2 PF07727.14 EDN03770.1 - 7.9e-54 182.8 0.0 2.7e-47 161.4 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN03770.1 - 9.4e-09 35.5 0.0 2.7e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN03770.1 - 7.9e-06 25.6 0.0 2.3e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain Pkinase PF00069.25 EDN03771.1 - 1e-14 54.6 0.1 4.6e-14 52.4 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03771.1 - 1e-08 34.8 0.1 1.9e-08 33.9 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Crr6 PF08847.11 EDN03772.1 - 0.082 12.6 0.0 0.2 11.3 0.0 1.6 2 0 0 2 2 2 0 Chlororespiratory reduction 6 YgaB PF14182.6 EDN03773.1 - 0.071 13.5 1.6 0.42 11.0 0.3 2.3 1 1 1 2 2 2 0 YgaB-like protein FAD_binding_8 PF08022.12 EDN03776.1 - 8.3e-13 48.4 0.0 3e-12 46.6 0.0 1.9 1 1 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EDN03776.1 - 2.3e-07 31.0 9.6 1.1e-06 28.7 9.6 2.1 1 1 0 1 1 1 1 Ferric reductase like transmembrane component DUF1772 PF08592.11 EDN03776.1 - 0.028 14.7 2.1 0.079 13.3 1.8 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) DUF3723 PF12520.8 EDN03777.1 - 7.2e-90 302.1 0.0 3.8e-78 263.4 0.0 3.2 2 1 1 3 3 3 3 Protein of unknown function (DUF3723) Patatin PF01734.22 EDN03778.1 - 0.0003 21.0 0.0 0.00056 20.1 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase Sgf11 PF08209.11 EDN03778.1 - 1.6 8.3 4.3 1.5 8.4 0.3 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) C1_1 PF00130.22 EDN03780.1 - 0.00021 21.1 2.5 0.00021 21.1 2.5 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Med9 PF07544.13 EDN03780.1 - 0.074 13.1 0.1 4.1 7.6 0.0 2.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 zf-RING_4 PF14570.6 EDN03780.1 - 0.094 12.5 6.9 1.3 8.8 0.8 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain C1_2 PF03107.16 EDN03780.1 - 0.14 12.5 2.4 0.13 12.6 0.5 1.9 2 0 0 2 2 2 0 C1 domain FYVE_2 PF02318.16 EDN03780.1 - 0.21 11.8 3.8 0.52 10.5 3.8 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger PNPase PF03726.14 EDN03780.1 - 0.21 12.1 2.3 0.51 10.9 0.1 2.7 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain PHD PF00628.29 EDN03780.1 - 2 8.4 7.3 4.9 7.1 7.3 1.7 1 0 0 1 1 1 0 PHD-finger Cwf_Cwc_15 PF04889.12 EDN03780.1 - 3 7.5 6.6 5.1 6.8 6.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-C3HC4_3 PF13920.6 EDN03780.1 - 4.9 7.1 7.3 0.84 9.6 1.3 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3181 PF11378.8 EDN03781.1 - 0.046 14.0 0.1 0.054 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) Radial_spoke PF04712.12 EDN03784.1 - 0.001 18.2 10.4 0.0011 18.0 10.4 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein FAM176 PF14851.6 EDN03784.1 - 0.0085 15.8 2.8 0.0097 15.6 2.8 1.2 1 0 0 1 1 1 1 FAM176 family DUF3449 PF11931.8 EDN03784.1 - 0.0096 15.7 2.8 0.011 15.5 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) Nop14 PF04147.12 EDN03784.1 - 0.027 12.7 9.1 0.028 12.7 9.1 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 EDN03784.1 - 0.028 14.7 16.5 0.039 14.2 16.5 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 EDN03784.1 - 0.03 14.3 4.3 0.037 14.0 4.3 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Med17 PF10156.9 EDN03784.1 - 0.059 12.1 3.4 0.075 11.7 3.4 1.0 1 0 0 1 1 1 0 Subunit 17 of Mediator complex TFB6 PF17110.5 EDN03784.1 - 0.088 12.5 1.2 0.093 12.5 1.2 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Pox_Ag35 PF03286.14 EDN03784.1 - 0.18 11.6 7.1 0.22 11.3 7.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sigma70_r1_1 PF03979.14 EDN03784.1 - 0.36 10.9 15.1 1.9 8.6 13.2 2.2 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 TRAP_alpha PF03896.16 EDN03784.1 - 0.44 9.7 5.8 0.49 9.6 5.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 EDN03784.1 - 0.49 8.4 14.5 0.55 8.3 14.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF4820 PF16091.5 EDN03784.1 - 1.8 7.9 4.5 2.2 7.6 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4746 PF15928.5 EDN03784.1 - 2.1 7.7 13.1 2.5 7.4 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RPN2_C PF18004.1 EDN03784.1 - 3.1 7.7 9.1 4.2 7.3 9.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CENP-B_dimeris PF09026.10 EDN03784.1 - 3.8 7.9 12.1 6.9 7.1 12.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Paf1 PF03985.13 EDN03784.1 - 5.9 5.8 17.1 7.5 5.4 17.1 1.1 1 0 0 1 1 1 0 Paf1 NOA36 PF06524.12 EDN03784.1 - 6.3 6.0 13.1 5.4 6.2 12.1 1.3 2 0 0 2 2 2 0 NOA36 protein DUF4637 PF15470.6 EDN03784.1 - 7.7 6.2 14.0 11 5.8 14.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Cytomega_UL84 PF06284.11 EDN03784.1 - 8.2 4.8 6.4 8.5 4.7 6.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PBP_sp32 PF07222.12 EDN03784.1 - 9 5.7 12.2 12 5.3 12.2 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 IMS PF00817.20 EDN03785.1 - 1.3e-37 129.1 0.0 2.3e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EDN03785.1 - 1.9e-08 35.0 0.0 1.1e-07 32.5 0.0 2.2 1 1 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4611 PF15387.6 EDN03785.1 - 0.0083 16.3 1.9 0.0083 16.3 1.9 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4611) E7 PF00527.18 EDN03785.1 - 0.12 12.5 1.3 0.73 10.1 0.9 2.4 2 0 0 2 2 2 0 E7 protein, Early protein Eapp_C PF10238.9 EDN03785.1 - 0.13 12.4 0.6 8.1 6.5 0.0 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein SepF PF04472.12 EDN03785.1 - 0.15 12.4 0.0 0.38 11.1 0.0 1.7 1 0 0 1 1 1 0 Cell division protein SepF Sigma70_ner PF04546.13 EDN03785.1 - 0.23 11.3 4.7 0.92 9.4 1.5 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region FAM176 PF14851.6 EDN03785.1 - 0.67 9.6 5.2 0.6 9.8 1.0 2.2 2 0 0 2 2 2 0 FAM176 family SDA1 PF05285.12 EDN03785.1 - 1.7 8.0 9.3 2.8 7.3 2.9 2.2 2 0 0 2 2 2 0 SDA1 TRAP_alpha PF03896.16 EDN03785.1 - 6 6.0 5.3 1.9 7.6 0.3 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 EDN03785.1 - 7.9 4.4 10.5 9.2 4.2 4.3 2.0 2 0 0 2 2 2 0 DNA polymerase phi Cnd2 PF05786.14 EDN03785.1 - 8.4 4.9 13.2 2.3 6.8 3.9 2.1 2 0 0 2 2 2 0 Condensin complex subunit 2 Pep_M12B_propep PF01562.19 EDN03786.1 - 0.0052 17.0 0.2 0.01 16.1 0.0 1.5 2 0 0 2 2 2 1 Reprolysin family propeptide Disintegrin PF00200.23 EDN03787.1 - 8.7e-17 61.7 34.1 8.7e-17 61.7 34.1 3.4 2 1 0 2 2 2 1 Disintegrin ADAM_CR_2 PF17771.1 EDN03787.1 - 5.2e-06 26.9 7.1 5.2e-06 26.9 7.1 3.8 1 1 1 2 2 2 1 ADAM cysteine-rich domain EF-hand_7 PF13499.6 EDN03788.1 - 4.3e-16 59.1 0.2 1.1e-09 38.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDN03788.1 - 1.7e-14 52.2 1.7 1.3e-05 24.4 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EDN03788.1 - 6.8e-14 50.5 3.0 6.2e-06 25.7 0.1 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EDN03788.1 - 3.4e-11 42.8 2.3 1.2e-08 34.6 0.2 2.6 2 1 0 2 2 2 2 EF-hand domain pair DUF3572 PF12096.8 EDN03788.1 - 0.0087 16.2 0.1 1.1 9.5 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3572) EF-hand_4 PF12763.7 EDN03788.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EDN03788.1 - 0.11 12.0 6.9 1 9.0 0.4 2.8 3 0 0 3 3 3 0 EF hand Metal_resist PF13801.6 EDN03788.1 - 0.22 11.7 7.6 0.24 11.6 0.9 3.1 3 0 0 3 3 3 0 Heavy-metal resistance MgsA_C PF12002.8 EDN03789.1 - 2.2e-56 190.4 0.1 3.6e-56 189.7 0.1 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EDN03789.1 - 4.5e-23 81.4 0.4 1.1e-22 80.1 0.4 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EDN03789.1 - 1.3e-13 51.5 0.1 2.9e-13 50.4 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDN03789.1 - 7e-09 35.6 0.0 1.4e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDN03789.1 - 5e-05 22.8 0.1 0.054 12.9 0.0 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDN03789.1 - 5.3e-05 23.0 0.1 0.0029 17.3 0.1 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 EDN03789.1 - 7.2e-05 22.8 0.1 0.004 17.1 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN03789.1 - 0.0007 20.0 0.2 0.19 12.1 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_3 PF07726.11 EDN03789.1 - 0.0017 18.2 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EDN03789.1 - 0.0038 17.2 0.4 0.27 11.2 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN03789.1 - 0.0059 16.9 0.1 0.027 14.8 0.1 2.0 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EDN03789.1 - 0.0065 15.7 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EDN03789.1 - 0.0065 15.7 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 EDN03789.1 - 0.0094 16.1 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 EDN03789.1 - 0.011 15.5 0.5 0.034 13.9 0.5 1.9 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDN03789.1 - 0.012 16.0 0.4 0.068 13.5 0.4 1.9 1 1 1 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EDN03789.1 - 0.049 12.7 0.0 0.24 10.5 0.0 2.1 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 SKI PF01202.22 EDN03789.1 - 0.052 13.7 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase TsaE PF02367.17 EDN03789.1 - 0.064 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDN03789.1 - 0.075 13.6 0.0 0.17 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf_UBZ PF18439.1 EDN03789.1 - 0.12 12.0 0.3 0.35 10.5 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger AAA_24 PF13479.6 EDN03789.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDN03789.1 - 0.16 11.2 0.1 0.41 9.9 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin NB-ARC PF00931.22 EDN03789.1 - 0.2 10.8 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Aminotran_1_2 PF00155.21 EDN03790.1 - 5.9e-57 193.5 0.0 1.5e-56 192.2 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDN03790.1 - 0.15 11.3 0.1 0.33 10.2 0.1 1.6 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family KH_1 PF00013.29 EDN03791.1 - 6.8e-48 160.4 14.5 6.4e-17 61.1 1.2 3.8 3 1 1 4 4 4 3 KH domain KH_2 PF07650.17 EDN03791.1 - 1.2e-12 47.4 1.6 0.0043 16.8 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EDN03791.1 - 1.1e-10 41.2 1.2 0.0079 16.1 0.0 3.4 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 EDN03791.1 - 2e-06 27.7 0.0 0.23 11.5 0.0 3.3 3 0 0 3 3 3 3 KH-like RNA-binding domain KH_5 PF13184.6 EDN03791.1 - 0.0061 16.6 5.2 12 6.1 0.1 3.8 4 0 0 4 4 4 3 NusA-like KH domain DUF389 PF04087.14 EDN03792.1 - 0.85 9.6 7.4 0.34 10.9 1.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF389) Chlorosome_CsmC PF11098.8 EDN03792.1 - 2.8 7.9 5.9 0.42 10.6 0.5 2.4 3 1 0 3 3 3 0 Chlorosome envelope protein C Ald_Xan_dh_C2 PF02738.18 EDN03794.1 - 9.9e-199 661.3 0.3 1.4e-198 660.8 0.3 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EDN03794.1 - 6.7e-45 152.9 0.0 1.5e-44 151.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EDN03794.1 - 3.1e-33 114.0 0.0 8.8e-33 112.6 0.0 1.9 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EDN03794.1 - 7e-29 99.7 0.1 1.6e-28 98.5 0.1 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.22 EDN03794.1 - 4.3e-26 91.4 0.0 9.7e-26 90.3 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.27 EDN03794.1 - 2.2e-09 37.1 1.2 4.2e-09 36.2 0.2 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 EDN03794.1 - 0.0052 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 DUF218 domain AAA_23 PF13476.6 EDN03798.1 - 0.0024 18.4 0.0 0.0036 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDN03798.1 - 0.0074 16.8 0.1 0.014 15.9 0.1 1.5 1 1 0 1 1 1 1 ABC transporter PRK PF00485.18 EDN03798.1 - 0.024 14.4 0.1 0.043 13.5 0.1 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 EDN03798.1 - 0.033 14.6 0.3 0.055 13.9 0.3 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EDN03798.1 - 0.033 13.9 0.0 0.096 12.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EDN03798.1 - 0.081 13.5 0.1 0.22 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDN03798.1 - 0.093 11.8 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.20 EDN03798.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_28 PF13521.6 EDN03798.1 - 0.11 12.7 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.23 EDN03799.1 - 1.6e-42 145.5 0.0 2.5e-37 128.4 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN03799.1 - 3.5e-05 24.1 0.0 7.2e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Integrin_alpha PF00357.20 EDN03799.1 - 0.6 10.2 0.0 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Integrin alpha cytoplasmic region HMG_box PF00505.19 EDN03800.1 - 3e-23 82.0 0.3 5.3e-23 81.2 0.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDN03800.1 - 7.7e-09 36.0 0.1 2e-08 34.7 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 EDN03800.1 - 0.084 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 CHDNT (NUC034) domain ODAPH PF15848.5 EDN03800.1 - 3 8.3 7.9 1.1 9.7 0.1 3.5 2 1 1 3 3 3 0 Odontogenesis associated phosphoprotein Ribosomal_S6e PF01092.19 EDN03801.1 - 2.7e-56 188.9 0.0 6.1e-56 187.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S6e Pribosyl_synth PF14572.6 EDN03802.1 - 5.5e-33 114.5 6.4 2.5e-26 92.8 4.6 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDN03802.1 - 1.3e-27 96.0 3.8 3.4e-26 91.4 0.3 3.5 2 2 1 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDN03802.1 - 3.9e-16 59.0 0.4 6.4e-16 58.3 0.4 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDN03802.1 - 0.0016 17.9 0.5 0.0025 17.3 0.5 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF913 PF06025.12 EDN03803.1 - 2.6e-134 447.8 0.0 2.6e-134 447.8 0.0 6.7 5 2 0 5 5 5 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EDN03803.1 - 6.1e-108 361.4 2.9 6.1e-108 361.4 2.9 4.4 5 0 0 5 5 5 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EDN03803.1 - 1.3e-79 267.9 0.1 2.2e-79 267.1 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EDN03803.1 - 9.5e-32 107.5 21.8 2e-10 39.7 1.2 4.1 3 0 0 3 3 3 3 Ubiquitin binding region UBA PF00627.31 EDN03803.1 - 0.0023 17.8 0.0 0.012 15.5 0.0 2.2 2 0 0 2 2 2 1 UBA/TS-N domain An_peroxidase PF03098.15 EDN03804.1 - 5.1e-14 51.7 0.0 5.4e-09 35.2 0.0 3.1 1 1 0 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EDN03804.1 - 7.7e-06 24.9 0.0 1.7e-05 23.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 Steroid_dh PF02544.16 EDN03805.1 - 1e-23 84.0 0.0 1.2e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EDN03805.1 - 0.00045 19.8 0.1 0.00053 19.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EDN03805.1 - 0.00087 19.7 0.2 0.0015 18.9 0.2 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase Glyco_transf_34 PF05637.12 EDN03806.1 - 1e-59 202.2 0.0 1.3e-59 201.8 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Ribosomal_L28 PF00830.19 EDN03807.1 - 3.9e-17 62.2 1.6 8.2e-17 61.2 1.6 1.5 1 0 0 1 1 1 1 Ribosomal L28 family TIP49 PF06068.13 EDN03808.1 - 6.2e-160 532.1 0.4 1.5e-129 432.2 0.1 2.0 2 0 0 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 EDN03808.1 - 5.8e-19 68.0 0.1 2.1e-18 66.2 0.0 2.0 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EDN03808.1 - 4.6e-10 40.0 0.1 2.6e-07 31.1 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDN03808.1 - 1.4e-07 31.4 0.1 4.6e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDN03808.1 - 0.00082 19.6 0.1 0.0017 18.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN03808.1 - 0.0026 18.1 0.2 0.007 16.8 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EDN03808.1 - 0.0061 15.9 0.2 0.015 14.6 0.2 1.6 1 0 0 1 1 1 1 Zeta toxin DnaB_C PF03796.15 EDN03808.1 - 0.014 14.7 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_25 PF13481.6 EDN03808.1 - 0.015 14.9 0.1 0.03 13.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EDN03808.1 - 0.015 15.7 0.1 0.15 12.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EDN03808.1 - 0.023 15.0 0.3 0.072 13.4 0.3 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDN03808.1 - 0.053 12.9 0.5 0.16 11.3 0.1 1.8 2 0 0 2 2 2 0 KaiC IstB_IS21 PF01695.17 EDN03808.1 - 0.067 12.9 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 EDN03808.1 - 0.086 12.8 0.1 0.23 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 EDN03808.1 - 0.087 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EDN03808.1 - 0.1 12.9 0.1 1.4 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDN03808.1 - 0.11 13.1 0.0 0.31 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDN03808.1 - 0.18 11.8 0.1 0.39 10.7 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Amino_oxidase PF01593.24 EDN03809.1 - 8.9e-11 41.7 0.0 0.0001 21.7 0.0 2.3 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDN03809.1 - 6.1e-09 36.0 0.1 1.4e-08 34.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDN03809.1 - 1.8e-05 24.5 0.0 0.001 18.7 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EDN03809.1 - 8e-05 22.2 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN03809.1 - 0.00028 20.2 0.0 0.0015 17.8 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN03809.1 - 0.0003 20.8 0.0 0.0076 16.2 0.1 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDN03809.1 - 0.00076 20.0 0.0 0.0033 18.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN03809.1 - 0.0015 17.8 0.0 0.0023 17.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FMO-like PF00743.19 EDN03809.1 - 0.0018 16.8 0.0 0.0027 16.2 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like HI0933_like PF03486.14 EDN03809.1 - 0.0021 16.8 0.0 0.0069 15.1 0.0 1.8 2 1 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EDN03809.1 - 0.016 14.3 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EDN03809.1 - 0.03 13.4 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 EDN03809.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EDN03809.1 - 0.14 11.4 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.12 EDN03809.1 - 0.16 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain V-SNARE PF05008.15 EDN03810.1 - 4.4e-21 75.1 6.0 4.4e-21 75.1 6.0 1.9 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EDN03810.1 - 2.3e-15 56.6 3.2 2.3e-15 56.6 3.2 2.5 3 1 0 3 3 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EDN03810.1 - 0.0025 17.7 1.8 0.0044 16.9 0.2 2.1 2 0 0 2 2 2 1 Sec20 SNARE PF05739.19 EDN03810.1 - 0.033 14.2 2.6 0.077 13.0 0.4 2.6 2 1 1 3 3 3 0 SNARE domain SPX PF03105.19 EDN03810.1 - 0.086 12.7 5.6 0.11 12.4 5.6 1.2 1 0 0 1 1 1 0 SPX domain Fusion_gly PF00523.18 EDN03810.1 - 0.11 10.7 0.1 0.11 10.7 0.1 2.4 2 1 1 3 3 3 0 Fusion glycoprotein F0 FtsX_ECD PF18075.1 EDN03810.1 - 0.12 13.0 3.1 0.26 11.9 3.1 1.5 1 0 0 1 1 1 0 FtsX extracellular domain DUF349 PF03993.12 EDN03810.1 - 0.13 12.5 8.4 0.43 10.9 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Synaptobrevin PF00957.21 EDN03810.1 - 2 8.2 5.1 0.67 9.8 0.2 2.6 3 0 0 3 3 3 0 Synaptobrevin YqjK PF13997.6 EDN03810.1 - 2.5 8.4 5.6 10 6.5 0.1 3.1 3 0 0 3 3 3 0 YqjK-like protein TBCA PF02970.16 EDN03810.1 - 4.1 7.8 9.7 3 8.2 4.1 2.8 2 1 0 2 2 2 0 Tubulin binding cofactor A Exonuc_VII_L PF02601.15 EDN03810.1 - 4.5 6.8 10.2 11 5.4 10.2 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF2407_C PF13373.6 EDN03811.1 - 3.1e-40 137.6 0.1 4.8e-40 137.0 0.1 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EDN03811.1 - 7.2e-36 122.9 0.0 1.3e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EDN03811.1 - 0.00079 19.1 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 EDN03811.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Fe-S_biosyn PF01521.20 EDN03812.1 - 1.7e-20 73.3 0.0 2.4e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Nucleic_acid_bd PF13820.6 EDN03812.1 - 0.057 13.3 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Putative nucleic acid-binding region Ndc1_Nup PF09531.10 EDN03812.1 - 1.5 7.4 6.0 1.6 7.4 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1741 PF08427.10 EDN03813.1 - 1.9e-94 315.7 0.2 2.9e-94 315.1 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) MRG PF05712.13 EDN03814.1 - 5.3e-58 195.6 0.2 8.9e-58 194.9 0.2 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EDN03814.1 - 4.7e-09 36.0 3.1 1.2e-08 34.8 3.1 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain IHO1 PF15771.5 EDN03814.1 - 0.037 12.8 0.1 0.037 12.8 0.1 1.9 1 1 0 2 2 2 0 Interactor of HORMAD1 protein 1 MID_MedPIWI PF18296.1 EDN03814.1 - 0.25 11.1 3.8 0.42 10.4 3.3 1.4 1 1 0 1 1 1 0 MID domain of medPIWI Cnl2_NKP2 PF09447.10 EDN03815.1 - 4.7e-28 97.1 0.8 7.9e-28 96.4 0.8 1.4 1 0 0 1 1 1 1 Cnl2/NKP2 family protein V-ATPase_G_2 PF16999.5 EDN03815.1 - 0.13 12.7 0.1 0.13 12.7 0.1 1.6 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Ctf8 PF09696.10 EDN03817.1 - 1.6e-49 167.9 0.0 2.1e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 Ctf8 PknG_rubred PF16919.5 EDN03817.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain Glyoxalase PF00903.25 EDN03818.1 - 9.2e-17 61.4 0.0 3.1e-14 53.2 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDN03818.1 - 1e-11 45.1 0.0 1e-05 25.8 0.0 2.6 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EDN03818.1 - 8.8e-06 25.9 0.0 0.73 9.9 0.0 3.4 3 0 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EDN03818.1 - 3.3e-05 24.1 0.0 0.013 15.7 0.0 3.1 3 0 0 3 3 3 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal RabGAP-TBC PF00566.18 EDN03819.1 - 3e-50 170.8 0.1 3e-50 170.8 0.1 2.5 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Cnn_1N PF07989.11 EDN03819.1 - 0.00079 19.5 19.2 0.0068 16.5 4.1 3.4 1 1 1 2 2 2 2 Centrosomin N-terminal motif 1 PPR_3 PF13812.6 EDN03819.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain YabA PF06156.13 EDN03819.1 - 3.8 8.2 15.6 2.7 8.7 3.7 3.1 1 1 1 2 2 2 0 Initiation control protein YabA TolA_bind_tri PF16331.5 EDN03819.1 - 7.2 6.8 11.9 0.28 11.3 3.0 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation Med9 PF07544.13 EDN03819.1 - 7.4 6.7 8.6 0.73 10.0 0.4 3.4 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 PPTA PF01239.22 EDN03820.1 - 4.8e-33 111.9 13.2 3.8e-07 29.6 0.0 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Tail_VII PF17091.5 EDN03820.1 - 0.038 13.9 0.3 0.069 13.0 0.3 1.3 1 0 0 1 1 1 0 Inovirus G7P protein Utp12 PF04003.12 EDN03823.1 - 5.8e-22 78.0 0.1 1e-21 77.2 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Bromodomain PF00439.25 EDN03825.1 - 1.4e-38 130.8 0.3 5.6e-20 71.2 0.3 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EDN03825.1 - 2.5e-18 66.0 0.9 8.5e-18 64.3 0.5 2.2 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation DUF3573 PF12097.8 EDN03825.1 - 0.19 10.5 4.1 0.3 9.9 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Macoilin PF09726.9 EDN03825.1 - 0.9 8.0 12.5 1.4 7.4 12.5 1.2 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 EDN03825.1 - 1.2 7.2 7.0 2.1 6.4 7.0 1.5 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HeLo PF14479.6 EDN03825.1 - 3 7.6 6.1 8.1 6.2 6.1 1.7 1 0 0 1 1 1 0 Prion-inhibition and propagation Sulfate_transp PF00916.20 EDN03826.1 - 1.1e-50 172.6 20.8 1.4e-50 172.2 20.8 1.0 1 0 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 EDN03826.1 - 0.079 13.4 18.6 2.8 8.4 4.4 3.8 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily HMG_box PF00505.19 EDN03827.1 - 2.3e-11 43.9 1.0 4.3e-11 43.1 1.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box MATalpha_HMGbox PF04769.12 EDN03827.1 - 0.07 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box PHD PF00628.29 EDN03831.1 - 2.6e-10 40.0 8.6 6.2e-10 38.8 8.6 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EDN03831.1 - 0.00011 21.7 3.7 0.00011 21.7 3.7 2.1 2 0 0 2 2 2 1 PHD-finger Herpes_UL95 PF03038.14 EDN03831.1 - 0.09 11.9 0.2 0.14 11.3 0.2 1.3 1 0 0 1 1 1 0 UL95 family DUF2098 PF09871.9 EDN03831.1 - 0.32 11.4 0.1 0.32 11.4 0.1 4.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) Prok-RING_1 PF14446.6 EDN03831.1 - 1 9.3 7.1 0.2 11.6 3.2 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_2 PF03107.16 EDN03831.1 - 1.2 9.5 6.0 0.48 10.8 1.8 2.3 2 0 0 2 2 2 0 C1 domain Rcd1 PF04078.13 EDN03832.1 - 1.1e-125 418.1 3.3 1.4e-125 417.8 3.3 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Ndc1_Nup PF09531.10 EDN03832.1 - 0.054 12.2 6.8 0.064 11.9 6.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 EDN03832.1 - 0.077 11.3 18.8 0.086 11.1 18.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 EDN03832.1 - 0.11 12.5 32.0 0.14 12.1 32.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CnrY PF17524.2 EDN03832.1 - 0.12 12.6 2.3 1.2 9.4 0.0 2.7 2 0 0 2 2 2 0 Anti-sigma factor CnrY CDRT4 PF15213.6 EDN03832.1 - 0.14 12.8 2.4 17 6.0 2.2 2.5 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein EPL1 PF10513.9 EDN03832.1 - 0.19 12.1 7.0 0.32 11.4 7.0 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like NST1 PF13945.6 EDN03832.1 - 0.27 11.3 12.9 0.49 10.5 12.9 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator MMR1 PF08505.10 EDN03832.1 - 0.65 10.2 14.1 0.98 9.7 14.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SRP-alpha_N PF04086.13 EDN03832.1 - 0.77 9.6 11.2 1.1 9.1 11.2 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF702 PF05142.12 EDN03832.1 - 0.85 10.1 10.7 2 8.9 10.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF702) BRF1 PF07741.13 EDN03832.1 - 1.7 9.0 9.6 3.9 7.9 9.6 1.6 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Macoilin PF09726.9 EDN03832.1 - 3.1 6.2 11.7 4 5.9 11.7 1.1 1 0 0 1 1 1 0 Macoilin family Folliculin PF11704.8 EDN03832.1 - 5.2 6.9 10.3 12 5.7 9.1 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Pex14_N PF04695.13 EDN03832.1 - 6.5 7.4 20.8 12 6.5 20.8 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Plasmodium_Vir PF05795.11 EDN03832.1 - 7.1 5.9 6.8 10 5.4 6.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SPATA3 PF15662.5 EDN03832.1 - 8.2 7.0 18.4 5.6 7.5 16.7 1.5 2 0 0 2 2 1 0 Spermatogenesis-associated protein 3 family MPM1 PF17234.2 EDN03832.1 - 8.3 6.6 12.3 14 5.9 12.3 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF2613 PF11021.8 EDN03833.1 - 0.91 9.7 6.4 36 4.6 4.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) DUF4690 PF15756.5 EDN03833.1 - 1.5 9.5 6.8 4.2 8.0 6.8 1.8 1 1 0 1 1 1 0 Small Novel Rich in Cartilage Podoplanin PF05808.11 EDN03833.1 - 2.4 8.2 5.7 0.7 10.0 1.3 2.1 2 0 0 2 2 2 0 Podoplanin MFS_1 PF07690.16 EDN03835.1 - 3.2e-32 111.8 36.6 6.4e-32 110.9 36.6 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN03835.1 - 1.7e-14 53.5 4.9 1.7e-14 53.5 4.9 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EDN03835.1 - 4.9e-10 38.5 10.8 7.1e-10 37.9 10.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDN03835.1 - 0.039 12.2 0.1 0.039 12.2 0.1 2.3 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Trypsin PF00089.26 EDN03836.1 - 6.7e-08 32.6 1.0 4.1e-07 30.0 0.7 2.3 1 1 1 2 2 2 1 Trypsin Trypsin_2 PF13365.6 EDN03836.1 - 0.0005 21.0 0.0 0.00075 20.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Pre-PUA PF17832.1 EDN03837.1 - 4.1e-10 40.2 0.4 2.1e-08 34.7 0.4 2.2 1 1 0 1 1 1 1 Pre-PUA-like domain SUI1 PF01253.22 EDN03838.1 - 1.8e-21 76.4 0.1 4e-21 75.3 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Kin17_mid PF10357.9 EDN03838.1 - 0.0043 17.0 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein Fungal_trans PF04082.18 EDN03839.1 - 1.5e-14 53.7 0.7 4.6e-14 52.1 0.7 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN03839.1 - 8.2e-09 35.4 7.2 1.9e-08 34.2 7.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ERG4_ERG24 PF01222.17 EDN03840.1 - 1.8e-133 445.4 18.5 2.1e-133 445.2 18.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Velvet PF11754.8 EDN03843.1 - 1.8e-51 175.5 0.0 7.2e-32 111.3 0.0 3.5 2 2 1 3 3 3 2 Velvet factor DUF4094 PF13334.6 EDN03844.1 - 0.019 15.4 0.6 0.019 15.4 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) MFS_1 PF07690.16 EDN03845.1 - 9.5e-33 113.6 25.2 9.5e-33 113.6 25.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Abhydrolase_3 PF07859.13 EDN03846.1 - 2.4e-66 223.6 0.0 3.1e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDN03846.1 - 7.8e-07 28.3 0.0 1.2e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EDN03846.1 - 1.8e-06 27.6 0.0 6.6e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EDN03846.1 - 2.1e-06 26.9 0.3 6.6e-06 25.3 0.3 1.7 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 EDN03846.1 - 0.065 12.7 0.8 0.21 11.0 0.8 1.9 1 1 0 1 1 1 0 Esterase PHB depolymerase DHDPS PF00701.22 EDN03848.1 - 2.4e-38 131.5 0.0 3.1e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family AP_endonuc_2 PF01261.24 EDN03848.1 - 0.18 11.3 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Ribonuc_L-PSP PF01042.21 EDN03849.1 - 2.6e-38 130.7 0.0 2.9e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP D-ser_dehydrat PF14031.6 EDN03850.1 - 1e-24 87.0 0.0 3.7e-24 85.2 0.0 1.9 2 0 0 2 2 2 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EDN03850.1 - 4e-15 56.1 0.0 5.4e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Pyridox_oxase_2 PF12766.7 EDN03851.1 - 0.0057 17.2 0.0 0.015 15.9 0.0 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Cyclase PF04199.13 EDN03852.1 - 6.6e-13 49.1 0.0 1.7e-12 47.7 0.0 1.6 1 1 0 1 1 1 1 Putative cyclase AA_permease_2 PF13520.6 EDN03853.1 - 1.5e-48 165.7 46.7 4.7e-40 137.7 19.6 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 EDN03853.1 - 3.5e-23 82.0 43.4 1.8e-22 79.6 19.8 2.0 1 1 1 2 2 2 2 Amino acid permease JmjC PF02373.22 EDN03856.1 - 1.2e-38 132.1 0.5 2e-38 131.3 0.5 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Carn_acyltransf PF00755.20 EDN03857.1 - 1.7e-177 591.6 1.8 1.4e-150 502.7 0.0 2.9 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase PFL-like PF02901.15 EDN03859.1 - 0.0026 16.5 1.4 0.0026 16.5 1.4 1.5 1 1 1 2 2 2 1 Pyruvate formate lyase-like DUF3746 PF12562.8 EDN03859.1 - 0.092 12.7 0.6 0.2 11.6 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) HalX PF08663.10 EDN03859.1 - 0.31 11.4 5.7 4.2 7.8 0.4 2.3 1 1 1 2 2 2 0 HalX domain Latarcin PF10279.9 EDN03859.1 - 0.88 10.0 4.1 2.2 8.7 4.1 1.9 1 1 0 1 1 1 0 Latarcin precursor AA_permease_2 PF13520.6 EDN03860.1 - 1.2e-62 212.2 40.4 7.6e-33 114.0 14.3 2.5 1 1 1 2 2 2 2 Amino acid permease C5-epim_C PF06662.13 EDN03862.1 - 0.061 12.8 0.2 13 5.2 0.0 2.4 3 0 0 3 3 3 0 D-glucuronyl C5-epimerase C-terminus Thioredox_DsbH PF03190.15 EDN03863.1 - 1.3e-70 236.5 0.0 1.7e-70 236.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EDN03863.1 - 9.4e-08 32.1 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like WD40 PF00400.32 EDN03864.1 - 2e-14 53.7 16.6 0.00027 21.7 0.5 5.8 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN03864.1 - 0.0024 18.2 0.1 1.3 9.3 0.1 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Reg_prop PF07494.11 EDN03864.1 - 0.05 13.8 0.1 2.8 8.5 0.0 2.9 2 0 0 2 2 2 0 Two component regulator propeller DUF771 PF05595.11 EDN03864.1 - 0.064 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF771) LSM14 PF12701.7 EDN03865.1 - 2.9e-25 88.2 0.0 3.7e-23 81.4 0.0 2.4 1 1 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EDN03865.1 - 1.3e-22 80.6 3.2 1.3e-22 80.6 3.2 2.1 2 1 0 2 2 2 1 FDF domain SM-ATX PF14438.6 EDN03865.1 - 0.013 15.7 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 Ataxin 2 SM domain ACBP PF00887.19 EDN03866.1 - 9.8e-21 73.8 0.0 3e-20 72.2 0.0 1.8 2 0 0 2 2 2 1 Acyl CoA binding protein CDC45 PF02724.14 EDN03866.1 - 5.7e-05 21.6 10.4 8.7e-05 21.0 10.4 1.2 1 0 0 1 1 1 1 CDC45-like protein MSA-2c PF12238.8 EDN03866.1 - 0.028 14.4 1.6 0.043 13.8 1.6 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF2456 PF10445.9 EDN03866.1 - 0.15 12.1 1.5 0.25 11.4 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) Nop14 PF04147.12 EDN03866.1 - 0.19 9.9 15.4 0.27 9.4 15.4 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EDN03866.1 - 0.33 10.3 18.2 0.48 9.8 18.2 1.3 1 0 0 1 1 1 0 SDA1 eIF-3c_N PF05470.12 EDN03866.1 - 0.53 8.5 11.4 0.79 8.0 11.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus YL1 PF05764.13 EDN03866.1 - 4.6 7.3 25.3 1.1 9.4 21.7 1.6 2 0 0 2 2 2 0 YL1 nuclear protein Apt1 PF10351.9 EDN03866.1 - 7.7 5.2 8.5 0.23 10.3 1.0 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain AAA_lid_6 PF17866.1 EDN03867.1 - 0.085 13.1 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA lid domain CHCH PF06747.13 EDN03868.1 - 6.7e-09 35.7 11.7 1e-06 28.7 5.2 2.4 2 0 0 2 2 2 2 CHCH domain CX9C PF16860.5 EDN03868.1 - 2.5e-05 24.2 8.6 0.0022 18.0 4.1 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 EDN03868.1 - 0.0014 18.9 7.1 0.21 11.9 1.6 3.0 2 1 0 3 3 3 2 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 EDN03868.1 - 0.1 12.8 10.5 1.6 9.0 0.9 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 EDN03868.1 - 0.15 12.1 13.1 0.27 11.3 4.3 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Prefoldin PF02996.17 EDN03870.1 - 3.1e-22 78.7 0.1 5.3e-22 78.0 0.1 1.3 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EDN03870.1 - 0.023 14.6 0.3 1.8 8.6 0.1 2.1 2 0 0 2 2 2 0 Prefoldin subunit tRNA-synt_2b PF00587.25 EDN03871.1 - 5.8e-29 101.3 0.0 1.7e-28 99.8 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDN03871.1 - 3.8e-09 36.6 0.0 1e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain zinc_ribbon_13 PF09855.9 EDN03871.1 - 0.048 13.8 0.1 0.9 9.8 0.0 2.4 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) CBF PF03914.17 EDN03872.1 - 1.9e-54 184.2 0.1 5.6e-54 182.7 0.1 1.9 1 0 0 1 1 1 1 CBF/Mak21 family SelK_SelG PF10961.8 EDN03872.1 - 0.05 14.2 0.2 3.4 8.3 0.0 3.2 3 0 0 3 3 3 0 Selenoprotein SelK_SelG LANC_like PF05147.13 EDN03873.1 - 1.7e-21 76.2 0.0 2.3e-10 39.6 0.0 3.1 2 1 1 3 3 3 3 Lanthionine synthetase C-like protein Ribosomal_L27 PF01016.19 EDN03873.1 - 0.08 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal L27 protein Goodbye PF17109.5 EDN03874.1 - 6.6e-39 133.1 0.0 2.6e-38 131.2 0.0 2.2 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain Aa_trans PF01490.18 EDN03874.1 - 3e-18 65.7 20.1 3e-18 65.7 20.1 1.9 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein TPR_19 PF14559.6 EDN03874.1 - 0.0011 19.4 0.5 0.061 13.8 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDN03874.1 - 0.054 14.3 0.5 0.76 10.8 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat SRP9-21 PF05486.12 EDN03874.1 - 0.2 12.0 0.2 0.49 10.8 0.2 1.6 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) TPR_6 PF13174.6 EDN03874.1 - 0.35 11.6 0.9 92 4.0 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DnaG_DnaB_bind PF08278.11 EDN03875.1 - 0.0039 17.8 0.3 0.0082 16.7 0.3 1.5 1 0 0 1 1 1 1 DNA primase DnaG DnaB-binding APS_kinase PF01583.20 EDN03877.1 - 6.9e-42 143.0 0.3 5.8e-27 94.5 0.1 2.1 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_18 PF13238.6 EDN03877.1 - 0.00022 21.7 0.0 0.00039 21.0 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDN03877.1 - 0.00034 20.8 0.0 0.00047 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDN03877.1 - 0.01 15.3 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EDN03877.1 - 0.011 16.1 0.0 0.011 16.1 0.0 1.2 1 1 0 1 1 1 0 AAA ATPase domain NCD2 PF04905.13 EDN03877.1 - 0.029 14.3 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) AAA_29 PF13555.6 EDN03877.1 - 0.1 12.3 0.7 0.18 11.6 0.7 1.5 1 1 0 1 1 1 0 P-loop containing region of AAA domain 6PF2K PF01591.18 EDN03877.1 - 0.14 11.4 0.0 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 6-phosphofructo-2-kinase V-ATPase_C PF03223.15 EDN03878.1 - 7.4e-119 397.4 0.0 8.4e-119 397.3 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C 4HBT PF03061.22 EDN03879.1 - 5.6e-12 45.9 0.0 9.3e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Ligase_CoA PF00549.19 EDN03881.1 - 6.6e-19 68.2 0.0 7.7e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 CoA-ligase DUF3435 PF11917.8 EDN03883.1 - 7.6e-37 127.2 0.0 4.4e-36 124.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) Myb_DNA-binding PF00249.31 EDN03887.1 - 5.6e-12 45.6 0.0 9.6e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN03887.1 - 1.6e-05 25.1 0.1 3.3e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain BCS1_N PF08740.11 EDN03888.1 - 6.9e-30 104.4 0.0 1.2e-29 103.6 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN03888.1 - 3.6e-19 69.5 0.0 9.4e-19 68.2 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN03888.1 - 0.0017 18.7 0.0 0.0049 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDN03888.1 - 0.0053 17.3 1.5 2.6 8.6 0.1 3.6 2 1 1 3 3 3 1 AAA domain PPV_E1_C PF00519.17 EDN03888.1 - 0.031 13.1 0.0 0.06 12.2 0.0 1.4 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 EDN03888.1 - 0.04 13.6 0.0 0.21 11.3 0.0 2.2 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.6 EDN03888.1 - 0.043 13.4 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN03888.1 - 0.062 13.3 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDN03888.1 - 0.089 13.0 0.1 1.8 8.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EDN03888.1 - 0.098 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 KaiC RuvB_N PF05496.12 EDN03888.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DDE_1 PF03184.19 EDN03891.1 - 5.3e-15 55.5 0.0 1.7e-14 53.8 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease PFL-like PF02901.15 EDN03891.1 - 0.0071 15.0 2.1 0.0082 14.8 1.5 1.3 1 1 0 1 1 1 1 Pyruvate formate lyase-like DDE_3 PF13358.6 EDN03891.1 - 0.035 13.9 0.2 0.18 11.5 0.1 2.1 1 1 1 2 2 2 0 DDE superfamily endonuclease P3A PF08727.11 EDN03891.1 - 0.044 13.2 0.0 6.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Poliovirus 3A protein like Pkinase PF00069.25 EDN03892.1 - 5.2e-28 98.1 0.0 4.4e-27 95.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03892.1 - 3.9e-11 42.7 0.0 2.1e-05 24.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase HTH_AsnC-type PF13404.6 EDN03892.1 - 0.14 12.0 0.1 0.34 10.8 0.1 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Chromo PF00385.24 EDN03893.1 - 4.9e-06 26.3 0.2 9.8e-06 25.4 0.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 EDN03894.1 - 2.5e-25 89.3 0.0 4.4e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN03894.1 - 6e-12 45.5 0.0 1.6e-11 44.0 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN03894.1 - 5.9e-07 29.8 0.2 1.6e-06 28.4 0.1 1.8 2 0 0 2 2 2 1 RNase H ORF_12_N PF18042.1 EDN03894.1 - 0.051 14.0 0.8 0.21 12.0 0.5 2.2 2 0 0 2 2 2 0 ORF 12 gene product N-terminal SCAN PF02023.17 EDN03895.1 - 0.092 12.6 1.5 0.22 11.3 1.5 1.6 1 0 0 1 1 1 0 SCAN domain Myb_DNA-binding PF00249.31 EDN03896.1 - 2e-05 24.7 0.0 4.2e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN03896.1 - 0.0011 19.2 0.0 0.0027 17.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PBP1_TM PF14812.6 EDN03896.1 - 3.6 8.0 12.3 0.17 12.3 5.4 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AAA PF00004.29 EDN03897.1 - 9.7e-19 68.1 0.0 2.6e-18 66.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN03897.1 - 0.00025 21.5 0.2 0.00092 19.6 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDN03897.1 - 0.00064 19.7 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN03897.1 - 0.0056 17.0 0.8 0.11 12.8 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_3 PF07726.11 EDN03897.1 - 0.017 15.0 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDN03897.1 - 0.017 14.8 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EDN03897.1 - 0.055 13.9 0.0 0.38 11.2 0.0 2.3 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 EDN03897.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EDN03897.1 - 0.087 13.1 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN03897.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2370 PF10176.9 EDN03898.1 - 0.068 12.8 0.2 0.087 12.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) APH PF01636.23 EDN03899.1 - 0.0031 17.5 0.0 0.0038 17.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RasGEF PF00617.19 EDN03901.1 - 1.4e-07 31.9 0.0 3.5e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 RasGEF domain F-box-like PF12937.7 EDN03902.1 - 2.6e-05 24.0 1.8 2.6e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 EDN03902.1 - 0.0002 21.2 0.1 0.00047 20.0 0.1 1.6 1 0 0 1 1 1 1 F-box LRR_4 PF12799.7 EDN03902.1 - 0.19 12.2 5.0 1.3 9.5 0.9 2.6 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Rad60-SLD PF11976.8 EDN03905.1 - 3e-20 71.8 0.4 3.5e-20 71.6 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EDN03905.1 - 2.5e-11 43.2 0.2 2.8e-11 43.0 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.12 EDN03905.1 - 0.04 14.3 0.1 0.049 14.0 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Nup84_Nup100 PF04121.13 EDN03906.1 - 3.5e-16 58.5 1.9 3.5e-16 58.5 1.9 1.9 2 1 0 2 2 2 1 Nuclear pore protein 84 / 107 Merozoite_SPAM PF07133.11 EDN03906.1 - 0.013 15.5 32.4 0.027 14.5 32.4 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Lin-8 PF03353.15 EDN03906.1 - 0.35 10.4 17.4 0.5 9.9 17.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SDA1 PF05285.12 EDN03906.1 - 4.5 6.6 38.7 5.9 6.2 38.4 1.3 1 1 0 1 1 1 0 SDA1 Nup84_Nup100 PF04121.13 EDN03907.1 - 1.7e-75 254.6 0.0 2e-75 254.4 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 HD PF01966.22 EDN03908.1 - 0.00089 19.5 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 HD domain Cation_ATPase_C PF00689.21 EDN03909.1 - 8.1e-44 149.5 9.3 8.1e-44 149.5 9.3 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EDN03909.1 - 1.8e-34 118.8 0.5 1.8e-34 118.8 0.5 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EDN03909.1 - 4e-24 84.5 0.0 7.3e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDN03909.1 - 4.2e-18 66.4 0.2 1.5e-17 64.6 0.2 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN03909.1 - 6.8e-06 25.7 0.0 2.3e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus LptF_LptG PF03739.14 EDN03909.1 - 0.023 13.5 5.2 0.045 12.6 5.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Pik1 PF11522.8 EDN03909.1 - 0.13 12.3 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Chromo PF00385.24 EDN03910.1 - 0.00038 20.3 0.1 0.0024 17.8 0.1 2.1 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase_fungal PF17667.1 EDN03911.1 - 3e-141 470.9 0.0 3.7e-141 470.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN03911.1 - 4.1e-07 29.6 0.0 7.1e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03911.1 - 0.0065 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN03911.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3091 PF11291.8 EDN03912.1 - 0.079 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) DEAD PF00270.29 EDN03913.1 - 2.2e-09 37.3 0.0 4.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN03913.1 - 5.5e-05 23.2 0.0 0.00014 21.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN03913.1 - 0.03 14.6 0.2 0.13 12.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain DUF2236 PF09995.9 EDN03914.1 - 4.8e-07 30.2 0.1 7.8e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Aldedh PF00171.22 EDN03915.1 - 1.5e-101 340.2 0.2 2e-101 339.8 0.2 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Tubulin PF00091.25 EDN03916.1 - 9e-54 182.7 0.0 2.3e-53 181.4 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDN03916.1 - 5.1e-42 143.0 0.1 8.5e-42 142.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 EDN03916.1 - 0.00069 18.9 0.0 0.016 14.5 0.0 2.1 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EDN03916.1 - 0.0039 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain RRM_1 PF00076.22 EDN03917.1 - 1.9e-16 59.6 0.4 5.2e-08 32.6 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN03917.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Pkinase PF00069.25 EDN03918.1 - 7.2e-66 222.2 0.0 1.3e-65 221.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03918.1 - 1.4e-34 119.5 0.0 9.3e-24 84.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN03918.1 - 9.5e-07 27.9 0.2 1.6e-06 27.2 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDN03918.1 - 3e-06 26.8 0.1 0.001 18.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EDN03918.1 - 8.2e-05 22.6 2.1 0.0057 16.6 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDN03918.1 - 0.014 14.4 0.1 0.025 13.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 EDN03918.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 EF1_GNE PF00736.19 EDN03919.1 - 3.8e-14 52.6 0.5 1.5e-10 41.1 0.6 2.5 2 0 0 2 2 2 2 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EDN03919.1 - 1.5e-07 31.7 2.8 1.5e-07 31.7 2.8 3.6 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 EDN03919.1 - 0.078 13.2 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AAA PF00004.29 EDN03920.1 - 2.9e-11 43.9 0.0 4.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN03920.1 - 2.1e-06 28.2 0.5 6.6e-05 23.4 0.5 2.2 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EDN03920.1 - 1.8e-05 24.3 0.0 0.00098 18.6 0.0 2.0 1 1 0 1 1 1 1 Bacterial TniB protein ATPase_2 PF01637.18 EDN03920.1 - 0.00014 21.8 0.2 0.44 10.4 0.1 2.1 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EDN03920.1 - 0.0027 18.0 0.1 0.0081 16.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EDN03920.1 - 0.0048 16.7 0.0 0.0052 16.5 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.6 EDN03920.1 - 0.0072 16.7 0.2 0.011 16.0 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDN03920.1 - 0.0094 16.2 0.0 0.02 15.2 0.1 1.6 2 1 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EDN03920.1 - 0.0097 15.6 0.4 0.017 14.9 0.4 1.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EDN03920.1 - 0.011 14.9 0.1 0.075 12.2 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.12 EDN03920.1 - 0.012 15.5 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EDN03920.1 - 0.018 15.0 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF853 PF05872.12 EDN03920.1 - 0.019 13.6 0.1 0.023 13.3 0.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Sigma54_activat PF00158.26 EDN03920.1 - 0.02 14.6 0.2 0.058 13.1 0.2 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain UvrD-helicase PF00580.21 EDN03920.1 - 0.021 14.3 0.3 0.037 13.5 0.2 1.4 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.14 EDN03920.1 - 0.035 14.1 0.1 0.057 13.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TrwB_AAD_bind PF10412.9 EDN03920.1 - 0.042 12.8 0.1 0.067 12.1 0.1 1.4 1 1 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 EDN03920.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EDN03920.1 - 0.12 11.9 0.1 0.53 9.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 EDN03920.1 - 0.13 11.6 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein ClpB_D2-small PF10431.9 EDN03921.1 - 2.4e-27 94.8 0.0 4.1e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_2 PF07724.14 EDN03921.1 - 0.074 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) MutS_V PF00488.21 EDN03922.1 - 5.6e-19 68.9 0.0 1.6e-14 54.4 0.0 3.0 2 1 1 3 3 3 2 MutS domain V MutS_III PF05192.18 EDN03922.1 - 1.7e-09 38.2 0.0 2.9e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 MutS domain III RdRP_3 PF00998.23 EDN03922.1 - 0.18 10.5 0.0 0.27 9.9 0.0 1.1 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase Sas10 PF09368.10 EDN03923.1 - 5.1e-29 100.6 9.4 5.1e-29 100.6 9.4 2.8 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EDN03923.1 - 5.7e-13 49.3 2.0 2e-12 47.6 0.0 2.9 2 1 1 3 3 3 1 Sas10/Utp3/C1D family adh_short PF00106.25 EDN03924.1 - 1.2e-23 83.6 0.0 1.9e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN03924.1 - 2.9e-13 49.9 0.0 4.9e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN03924.1 - 1.2e-08 35.1 0.0 2.2e-05 24.5 0.0 2.1 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EDN03924.1 - 0.00018 21.0 0.0 0.00027 20.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EDN03924.1 - 0.0014 17.9 0.2 0.0025 17.2 0.2 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EDN03924.1 - 0.0027 17.2 0.1 0.0054 16.2 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 EDN03924.1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EDN03924.1 - 0.02 14.5 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EDN03924.1 - 0.052 12.8 0.0 0.077 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDN03924.1 - 0.055 13.9 0.0 0.094 13.2 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 EDN03924.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EDN03924.1 - 0.11 12.5 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Ribosomal_L6e PF01159.19 EDN03928.1 - 8.4e-40 135.8 0.7 8.4e-40 135.8 0.7 1.4 2 0 0 2 2 2 1 Ribosomal protein L6e DUF2476 PF10630.9 EDN03928.1 - 0.27 11.4 1.5 2.3 8.3 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2476) Proteasom_Rpn13 PF04683.13 EDN03929.1 - 2.9e-25 88.6 0.0 4.3e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EDN03929.1 - 6.9e-12 45.5 1.5 4e-10 39.9 1.5 2.2 1 1 0 1 1 1 1 UCH-binding domain Ion_trans PF00520.31 EDN03930.1 - 1.4e-121 404.3 67.2 1.2e-41 142.5 2.6 5.2 4 2 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 EDN03930.1 - 0.00048 18.9 55.6 0.0018 17.0 1.2 6.2 6 0 0 6 6 6 4 Polycystin cation channel GPHH PF16905.5 EDN03930.1 - 0.0016 18.1 0.0 0.0036 17.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_1 PF00036.32 EDN03930.1 - 0.0033 16.8 0.0 0.011 15.2 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EDN03930.1 - 0.043 14.3 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EDN03930.1 - 0.11 12.5 0.0 0.5 10.4 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain DAGK_cat PF00781.24 EDN03932.1 - 2.1e-25 88.8 0.0 4e-25 87.9 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Nop52 PF05997.12 EDN03933.1 - 7.9e-50 169.6 0.0 2.7e-39 135.2 0.1 2.1 2 0 0 2 2 2 2 Nucleolar protein,Nop52 NOT2_3_5 PF04153.18 EDN03933.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family TAN PF11640.8 EDN03933.1 - 0.18 11.9 0.1 0.41 10.8 0.1 1.6 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Pkinase_fungal PF17667.1 EDN03934.1 - 9.5e-132 439.6 0.0 1.2e-131 439.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EDN03934.1 - 0.11 12.1 0.0 4.9 6.7 0.0 2.2 2 0 0 2 2 2 0 RIO1 family DUF3435 PF11917.8 EDN03935.1 - 5e-117 391.4 0.7 1.7e-82 277.6 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) zf-C2H2_4 PF13894.6 EDN03935.1 - 0.59 11.1 5.2 4.2 8.5 0.6 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger rve PF00665.26 EDN03936.1 - 1.4e-11 44.6 0.0 3.2e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN03936.1 - 0.00024 20.9 0.1 0.00077 19.3 0.1 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 EDN03936.1 - 0.0006 19.8 2.5 0.0014 18.6 2.5 1.6 1 0 0 1 1 1 1 Zinc knuckle RVT_2 PF07727.14 EDN03936.1 - 0.00071 19.3 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SLD5_C PF16922.5 EDN03936.1 - 0.16 12.2 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus zf-CCHC_5 PF14787.6 EDN03936.1 - 1.5 8.6 4.7 0.74 9.6 1.7 2.0 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger RVT_1 PF00078.27 EDN03937.1 - 7e-25 87.8 0.0 1.2e-24 87.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN03937.1 - 5.8e-12 46.0 0.0 1.2e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 RNase H Pkinase PF00069.25 EDN03938.1 - 3.4e-30 105.3 0.5 2.3e-18 66.5 0.1 3.2 1 1 1 2 2 2 2 Protein kinase domain KA1 PF02149.19 EDN03938.1 - 2.1e-16 59.5 0.4 4.7e-16 58.3 0.4 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Pkinase_Tyr PF07714.17 EDN03938.1 - 4.5e-15 55.6 0.1 9.7e-09 34.9 0.1 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDN03938.1 - 0.023 14.0 0.0 0.2 10.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like DUF1604 PF07713.13 EDN03939.1 - 7.8e-41 137.8 0.9 7.8e-41 137.8 0.9 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EDN03939.1 - 3.3e-07 30.1 0.5 3.3e-07 30.1 0.5 2.2 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EDN03939.1 - 0.034 14.2 4.6 0.036 14.2 1.2 2.9 2 1 0 2 2 2 0 G-patch domain DUF5109 PF17134.4 EDN03939.1 - 0.23 11.4 0.4 25 4.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5109) NAM-associated PF14303.6 EDN03940.1 - 0.47 11.2 5.7 1.5 9.5 5.4 1.9 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain Pkinase PF00069.25 EDN03941.1 - 2e-20 73.3 0.0 2e-14 53.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN03941.1 - 3.8e-06 26.4 0.0 0.0042 16.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase GIT_CC PF16559.5 EDN03942.1 - 0.056 13.3 0.2 0.081 12.8 0.2 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CCDC92 PF14916.6 EDN03942.1 - 0.057 13.2 0.2 0.085 12.6 0.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain of unknown function UBD PF16455.5 EDN03943.1 - 5.1e-39 132.7 0.0 9.2e-39 131.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EDN03943.1 - 0.0008 19.1 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Cu-oxidase_4 PF02578.15 EDN03943.1 - 0.042 13.5 0.2 0.53 9.9 0.2 2.0 1 1 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase DUF2407 PF10302.9 EDN03943.1 - 0.084 13.4 0.1 0.35 11.5 0.0 2.0 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EDN03943.1 - 0.09 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SIKE PF05769.11 EDN03944.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 SIKE family Exo_endo_phos_2 PF14529.6 EDN03945.1 - 1.6e-07 31.2 0.0 0.0014 18.5 0.0 2.6 1 1 1 2 2 2 2 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN03945.1 - 0.0006 19.4 0.0 0.0018 17.8 0.0 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 EDN03946.1 - 1e-22 80.8 0.0 1.5e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SET PF00856.28 EDN03948.1 - 1e-17 65.0 0.0 2.5e-17 63.8 0.0 1.7 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 EDN03948.1 - 3e-10 40.7 0.5 3e-10 40.7 0.5 2.5 2 1 0 2 2 2 1 Pre-SET motif AWS PF17907.1 EDN03948.1 - 0.019 15.0 1.3 0.019 15.0 1.3 3.2 4 0 0 4 4 4 0 AWS domain PALP PF00291.25 EDN03948.1 - 0.066 12.6 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Adaptin_N PF01602.20 EDN03949.1 - 1.1e-95 321.2 8.4 1.1e-95 321.2 8.4 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EDN03949.1 - 7.8e-60 200.8 0.3 1.7e-59 199.7 0.3 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EDN03949.1 - 3.9e-56 188.5 0.0 1.1e-55 187.1 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EDN03949.1 - 5.9e-13 49.2 8.5 2.2e-08 34.3 0.0 2.9 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN03949.1 - 8.6e-09 35.7 5.8 0.001 19.4 0.0 5.5 2 1 3 5 5 5 4 HEAT repeats Coatomer_g_Cpla PF16381.5 EDN03949.1 - 0.00033 20.7 0.0 0.0018 18.4 0.0 2.3 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 EDN03949.1 - 0.00055 20.0 2.5 3.5 8.1 0.1 5.6 6 0 0 6 6 6 1 HEAT repeat AP4E_app_platf PF14807.6 EDN03949.1 - 0.0059 16.9 0.2 0.025 14.9 0.2 2.2 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform HEAT_EZ PF13513.6 EDN03949.1 - 0.011 16.2 2.4 2.6 8.7 0.0 4.7 5 0 0 5 5 5 0 HEAT-like repeat DUF5578 PF17741.1 EDN03949.1 - 0.026 13.9 1.9 2.2 7.6 0.1 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5578) Arm PF00514.23 EDN03949.1 - 0.033 14.2 1.4 5.7 7.1 0.0 4.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Mago_nashi PF02792.14 EDN03950.1 - 1.2e-19 70.9 1.5 1.4e-19 70.7 1.5 1.1 1 0 0 1 1 1 1 Mago nashi protein Vac_ImportDeg PF09783.9 EDN03951.1 - 1.6e-43 148.3 2.3 3.8e-42 143.8 0.3 2.1 1 1 1 2 2 2 2 Vacuolar import and degradation protein PAN_2 PF08276.11 EDN03952.1 - 0.62 10.2 5.4 0.17 12.0 1.5 1.9 2 0 0 2 2 2 0 PAN-like domain MMgT PF10270.9 EDN03953.1 - 8.4e-32 109.5 0.0 1e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter DUF3592 PF12158.8 EDN03953.1 - 0.11 12.6 1.0 1.2 9.2 1.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3592) FAD_binding_4 PF01565.23 EDN03954.1 - 3.8e-26 91.5 0.1 6.6e-26 90.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain UQ_con PF00179.26 EDN03956.1 - 2.8e-07 30.3 0.0 5.6e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme FYVE_2 PF02318.16 EDN03956.1 - 0.16 12.2 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger RNB PF00773.19 EDN03957.1 - 1.8e-68 231.3 0.9 3.1e-46 158.2 0.0 2.5 1 1 1 2 2 2 2 RNB domain Dis3l2_C_term PF17877.1 EDN03957.1 - 1.7e-26 92.4 0.3 7.1e-26 90.4 0.0 2.4 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal OB_Dis3 PF17849.1 EDN03957.1 - 1.9e-25 88.6 0.0 4.8e-25 87.4 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 EDN03957.1 - 3e-05 23.8 0.0 7.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 EDN03957.1 - 6.2e-05 23.1 0.0 0.16 12.2 0.0 2.7 2 0 0 2 2 2 2 Cold shock domain CAF1-p150_C2 PF15539.6 EDN03957.1 - 0.027 13.9 3.5 1.2 8.5 0.7 2.5 2 0 0 2 2 2 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term GLE1 PF07817.13 EDN03958.1 - 6e-38 130.5 0.0 9.3e-38 129.9 0.0 1.3 1 0 0 1 1 1 1 GLE1-like protein PCSK9_C2 PF18464.1 EDN03958.1 - 0.036 14.1 0.1 0.096 12.7 0.1 1.7 1 0 0 1 1 1 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain SOBP PF15279.6 EDN03958.1 - 0.098 13.3 5.4 0.15 12.7 5.4 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein AF-4 PF05110.13 EDN03958.1 - 1.5 6.8 25.8 1.8 6.6 25.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Asp-B-Hydro_N PF05279.11 EDN03958.1 - 2.1 8.4 37.4 3.9 7.5 37.4 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SRP-alpha_N PF04086.13 EDN03958.1 - 2.7 7.8 30.5 3.8 7.4 30.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DDE_3 PF13358.6 EDN03959.1 - 1.5e-05 24.8 0.8 3.4e-05 23.6 0.2 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-3CxxC PF13695.6 EDN03960.1 - 1.4e-14 54.4 0.1 3.4e-14 53.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding domain RVT_1 PF00078.27 EDN03961.1 - 2.9e-25 89.1 0.0 4.9e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN03961.1 - 4.4e-12 46.4 0.0 9.2e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 RNase H CdvA PF18822.1 EDN03962.1 - 9.1 6.1 35.5 0.076 12.8 11.2 5.2 2 2 2 5 5 5 0 CdvA-like coiled-coil domain Glyco_hydro_17 PF00332.18 EDN03963.1 - 4.6e-41 141.4 0.5 7.1e-40 137.5 0.5 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 Myb_DNA-binding PF00249.31 EDN03964.1 - 5.6e-05 23.3 0.2 0.28 11.4 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN03964.1 - 0.00082 19.6 0.3 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain CDK2AP PF09806.9 EDN03964.1 - 2.3 8.2 7.5 0.63 10.1 3.4 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein EMP24_GP25L PF01105.24 EDN03966.1 - 6.4e-07 29.5 0.0 7.4e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD KR PF08659.10 EDN03968.1 - 1.9e-24 86.6 1.5 1.2e-12 48.1 0.1 2.4 1 1 1 2 2 2 2 KR domain Fungal_trans PF04082.18 EDN03968.1 - 6.4e-13 48.3 0.1 1.2e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EDN03968.1 - 4.9e-12 46.0 0.0 9.9e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ADH_zinc_N PF00107.26 EDN03968.1 - 0.00043 20.3 0.0 0.00098 19.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDN03968.1 - 0.0013 19.8 0.0 0.0037 18.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EDN03968.1 - 0.003 17.0 0.3 0.0074 15.8 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase Epimerase PF01370.21 EDN03968.1 - 0.016 14.7 0.1 0.049 13.1 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EDN03968.1 - 0.019 14.1 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ADH_N PF08240.12 EDN03968.1 - 0.035 14.0 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain F420_oxidored PF03807.17 EDN03968.1 - 0.052 14.1 0.1 0.17 12.5 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EDN03968.1 - 0.09 12.8 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HpcH_HpaI PF03328.14 EDN03969.1 - 2.8e-09 36.5 0.0 3.5e-05 23.0 0.0 2.1 2 0 0 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family DUF4192 PF13830.6 EDN03969.1 - 0.052 13.6 0.1 0.066 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) CS PF04969.16 EDN03970.1 - 1.1e-06 29.6 0.1 1.5e-06 29.1 0.1 1.1 1 0 0 1 1 1 1 CS domain FAD_binding_1 PF00667.20 EDN03970.1 - 0.14 11.7 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain NDC10_II PF16787.5 EDN03972.1 - 3.4e-42 144.6 6.9 2.3e-21 76.2 0.0 2.5 1 1 1 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN03972.1 - 6.8e-11 42.3 1.5 1.4e-10 41.3 0.0 2.4 3 0 0 3 3 3 1 Transcriptional activator of glycolytic enzymes DRY_EERY PF09750.9 EDN03972.1 - 0.018 15.3 0.4 0.054 13.8 0.4 1.7 1 0 0 1 1 1 0 Alternative splicing regulator DUF4887 PF16228.5 EDN03972.1 - 0.02 15.1 1.5 0.02 15.1 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4887) PSII_Pbs27 PF13326.6 EDN03972.1 - 0.032 14.6 0.2 0.063 13.6 0.2 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 FUSC PF04632.12 EDN03972.1 - 0.06 11.9 0.4 0.1 11.1 0.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Dot_icm_IcmQ PF09475.10 EDN03972.1 - 0.14 11.6 2.7 0.39 10.2 1.3 2.2 2 0 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Fungal_trans PF04082.18 EDN03973.1 - 2e-22 79.5 0.0 2.4e-22 79.3 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3716 PF12511.8 EDN03974.1 - 4.3e-12 45.9 2.5 5.6e-12 45.5 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Methyltransf_3 PF01596.17 EDN03975.1 - 9.5e-26 90.3 0.0 1.5e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EDN03975.1 - 4.3e-15 56.6 0.0 6.9e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN03975.1 - 4.8e-09 36.2 0.0 6.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN03975.1 - 1.5e-06 28.8 0.0 3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN03975.1 - 6e-05 23.6 0.0 0.00012 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EDN03975.1 - 0.00098 18.8 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 EDN03975.1 - 0.0028 18.4 0.0 0.0054 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDN03975.1 - 0.0029 17.4 0.0 0.0039 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EDN03975.1 - 0.084 12.2 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase p450 PF00067.22 EDN03976.1 - 1.9e-71 241.2 0.0 2.2e-71 241.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.12 EDN03977.1 - 4.2e-05 23.4 0.0 8.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AMP-binding PF00501.28 EDN03978.1 - 3e-158 526.9 0.0 4.2e-84 282.6 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EDN03978.1 - 3.2e-66 223.9 0.0 5.8e-25 87.9 0.0 5.0 3 1 0 4 4 4 4 Condensation domain PP-binding PF00550.25 EDN03978.1 - 1.7e-10 41.1 0.1 1e-09 38.6 0.0 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EDN03978.1 - 0.0014 19.5 0.0 0.38 11.8 0.0 2.6 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain DUF3405 PF11885.8 EDN03979.1 - 3.9e-229 761.6 0.0 4.5e-229 761.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) UPRTase PF14681.6 EDN03980.1 - 0.16 11.4 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Arf PF00025.21 EDN03982.1 - 4.2e-66 221.7 0.2 6e-66 221.2 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDN03982.1 - 4.5e-13 49.5 0.0 5.8e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDN03982.1 - 1.5e-12 47.3 0.0 1.9e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDN03982.1 - 1.1e-11 44.5 1.1 1.7e-08 34.1 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EDN03982.1 - 6.5e-11 42.1 0.0 8.5e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EDN03982.1 - 6.5e-09 35.5 0.0 8.4e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDN03982.1 - 8.9e-05 22.6 0.0 0.00012 22.1 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EDN03982.1 - 0.12 11.7 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase rve PF00665.26 EDN03983.1 - 1.1e-12 48.2 0.1 2.5e-12 47.0 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN03983.1 - 0.014 15.2 3.0 0.028 14.1 3.0 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN03983.1 - 0.017 15.0 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN03983.1 - 0.06 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_3 PF14244.6 EDN03983.1 - 0.064 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN03983.1 - 0.17 11.6 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) NDUFA12 PF05071.16 EDN03983.1 - 0.23 12.3 0.2 0.23 12.3 0.2 3.0 3 0 0 3 3 3 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Phage_min_cap2 PF06152.11 EDN03983.1 - 0.34 9.8 1.5 0.56 9.1 1.5 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 CorA PF01544.18 EDN03984.1 - 0.0012 18.3 0.4 0.0012 18.3 0.4 2.3 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein Bee_toxin PF17454.2 EDN03984.1 - 0.043 13.8 0.5 0.085 12.9 0.5 1.5 1 0 0 1 1 1 0 Honey bee toxin Ribosomal_L1 PF00687.21 EDN03985.1 - 1.5e-47 162.0 0.2 1.7e-47 161.8 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family UBA_4 PF14555.6 EDN03986.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain WH2 PF02205.20 EDN03987.1 - 2e-09 36.9 0.8 2e-09 36.9 0.8 2.0 2 0 0 2 2 2 1 WH2 motif CAP_N PF01213.19 EDN03987.1 - 0.0079 15.7 10.6 0.0079 15.7 10.6 6.6 2 2 3 5 5 5 1 Adenylate cyclase associated (CAP) N terminal zf-B_box PF00643.24 EDN03988.1 - 2 8.6 12.5 0.086 13.0 1.5 3.3 3 0 0 3 3 3 0 B-box zinc finger LSM PF01423.22 EDN03989.1 - 2.3e-14 52.8 0.1 3.5e-14 52.2 0.1 1.2 1 0 0 1 1 1 1 LSM domain Peptidase_U32 PF01136.19 EDN03989.1 - 0.12 11.6 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Peptidase family U32 SURF4 PF02077.15 EDN03992.1 - 1.4e-94 316.6 6.8 1.6e-94 316.5 6.8 1.0 1 0 0 1 1 1 1 SURF4 family UPF0139 PF03669.13 EDN03992.1 - 0.036 13.9 2.3 0.16 11.8 1.7 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0139) T2SSppdC PF12528.8 EDN03993.1 - 0.14 13.0 0.1 0.29 11.9 0.1 1.6 1 0 0 1 1 1 0 Type II secretion prepilin peptidase dependent protein C eIF_4EBP PF05456.11 EDN03993.1 - 0.28 11.1 6.9 0.64 10.0 0.8 3.1 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) FtsL PF04999.13 EDN03993.1 - 0.88 9.6 3.4 1.5 8.8 3.4 1.4 1 0 0 1 1 1 0 Cell division protein FtsL IU_nuc_hydro PF01156.19 EDN03994.1 - 2.3e-54 185.1 0.0 6.9e-54 183.5 0.0 1.6 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase p450 PF00067.22 EDN03996.1 - 1e-26 93.7 0.0 1.2e-26 93.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EDN03997.1 - 3.3e-15 55.8 0.2 5.7e-15 55.1 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN03997.1 - 3.1e-07 30.4 9.2 5.8e-07 29.5 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EDN03998.1 - 4.7e-16 58.7 24.2 9.8e-16 57.6 20.1 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF3040 PF11239.8 EDN03998.1 - 4.7 7.5 7.8 0.56 10.5 0.9 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Cu_amine_oxid PF01179.20 EDN03999.1 - 2e-160 534.2 0.0 2.5e-160 533.9 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EDN03999.1 - 6.1e-05 23.4 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EDN03999.1 - 0.0041 17.3 0.0 0.008 16.4 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Rad51 PF08423.11 EDN04000.1 - 2.3e-40 138.5 0.0 1.9e-37 128.9 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 EDN04000.1 - 1.3e-08 34.7 0.0 2.4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EDN04000.1 - 5.9e-06 25.8 0.1 0.00093 18.6 0.0 2.4 2 0 0 2 2 2 2 KaiC RecA PF00154.21 EDN04000.1 - 0.00032 20.3 0.1 0.15 11.5 0.0 2.2 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_22 PF13401.6 EDN04000.1 - 0.17 12.2 0.0 0.5 10.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDN04000.1 - 0.17 12.4 0.0 0.33 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter FA_desaturase PF00487.24 EDN04001.1 - 3.9e-24 85.9 25.5 1e-23 84.5 25.5 1.6 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EDN04001.1 - 3.1e-07 30.7 0.0 7.4e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) MPTase-PolyVal PF18818.1 EDN04001.1 - 0.046 13.8 0.3 0.46 10.6 0.1 2.1 1 1 1 2 2 2 0 Metallopeptidase superfamily domain TRAPPC10 PF12584.8 EDN04002.1 - 5.1e-37 127.0 0.0 8.7e-37 126.2 0.0 1.4 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Ank_5 PF13857.6 EDN04002.1 - 1.1e-10 41.5 4.8 5.8e-07 29.7 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN04002.1 - 3.6e-09 36.6 6.2 0.0002 21.6 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EDN04002.1 - 4.5e-09 36.7 0.4 1.8e-08 34.8 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) TIG PF01833.24 EDN04002.1 - 9.9e-09 35.2 0.3 9.9e-09 35.2 0.3 3.3 4 0 0 4 4 4 1 IPT/TIG domain Ank_2 PF12796.7 EDN04002.1 - 7e-08 33.0 0.0 1.8e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN04002.1 - 1.2e-06 28.4 1.3 0.075 13.6 0.2 3.0 2 0 0 2 2 2 2 Ankyrin repeat Foie-gras_1 PF11817.8 EDN04002.1 - 0.055 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Foie gras liver health family 1 Pro_isomerase PF00160.21 EDN04005.1 - 3.3e-48 163.9 0.5 3.7e-48 163.8 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD tRNA-synt_2c PF01411.19 EDN04006.1 - 1.8e-209 696.8 0.0 2.7e-209 696.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EDN04006.1 - 3.7e-18 65.4 0.6 9.1e-18 64.1 0.6 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EDN04006.1 - 4.9e-11 43.2 1.1 4.9e-11 43.2 1.1 1.8 2 0 0 2 2 2 1 DHHA1 domain DUF3752 PF12572.8 EDN04008.1 - 9.4e-48 162.6 11.1 9.4e-48 162.6 11.1 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3752) LisH_TPL PF17814.1 EDN04009.1 - 0.45 10.2 1.9 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 LisH-like dimerisation domain APC_u15 PF16636.5 EDN04012.1 - 0.28 11.6 5.4 8.2 6.9 0.1 3.1 2 0 0 2 2 2 0 Unstructured region on APC between APC_crr regions 5 and 6 A_deaminase PF00962.22 EDN04013.1 - 3.5e-120 401.3 0.0 4.8e-120 400.8 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase F-box PF00646.33 EDN04014.1 - 0.19 11.7 0.0 0.53 10.2 0.0 1.7 1 0 0 1 1 1 0 F-box domain SH3_9 PF14604.6 EDN04015.1 - 1.7e-15 56.6 1.1 8.4e-12 44.8 0.5 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EDN04015.1 - 8.2e-15 54.1 1.6 6.3e-09 35.3 0.4 2.4 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 EDN04015.1 - 1.4e-14 53.9 0.0 3.2e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 EDN04015.1 - 6.2e-07 29.0 0.0 2.1e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain PBP PF01161.20 EDN04016.1 - 1.7e-15 57.5 0.1 2.1e-15 57.2 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Dynamin_M PF01031.20 EDN04017.1 - 3.3e-111 371.1 0.0 5.8e-111 370.3 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region GED PF02212.18 EDN04017.1 - 4.3e-31 106.9 0.3 4.3e-31 106.9 0.3 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain Dynamin_N PF00350.23 EDN04017.1 - 2.2e-14 53.9 1.2 2.9e-13 50.2 0.0 2.8 3 0 0 3 3 3 1 Dynamin family GMC_oxred_N PF00732.19 EDN04018.1 - 4.7e-66 223.2 0.0 6.1e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN04018.1 - 8.2e-31 107.5 0.0 2.4e-30 106.0 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDN04018.1 - 3.3e-06 26.4 1.1 0.0012 18.1 0.5 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EDN04018.1 - 2.3e-05 24.6 0.3 6.2e-05 23.2 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EDN04018.1 - 3.2e-05 23.2 0.1 4.8e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EDN04018.1 - 0.0001 22.0 1.9 0.00041 20.0 2.0 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDN04018.1 - 0.00017 20.4 0.3 0.014 14.1 0.1 3.0 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_2 PF07992.14 EDN04018.1 - 0.00061 19.1 0.4 0.0046 16.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN04018.1 - 0.0016 17.7 0.4 0.0056 15.9 0.1 1.9 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EDN04018.1 - 0.013 14.8 0.2 0.099 11.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDN04018.1 - 0.014 14.7 0.1 0.022 14.0 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EDN04018.1 - 0.079 13.5 0.1 0.7 10.5 0.1 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EDN04018.1 - 0.095 13.0 0.0 0.7 10.2 0.0 2.4 2 1 1 3 3 3 0 TrkA-N domain UAA PF08449.11 EDN04019.1 - 5.5e-37 127.6 3.0 7.1e-37 127.2 3.0 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDN04019.1 - 2.9 8.1 10.5 3.6 7.8 9.7 1.7 1 1 0 1 1 1 0 EamA-like transporter family Rad17 PF03215.15 EDN04020.1 - 6.1e-11 42.6 0.0 2.9e-05 24.1 0.0 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain ELMO_CED12 PF04727.13 EDN04021.1 - 2.4e-51 174.4 0.1 5.4e-51 173.2 0.1 1.6 2 0 0 2 2 2 1 ELMO/CED-12 family PH_12 PF16457.5 EDN04021.1 - 6.2e-36 123.9 0.7 4.9e-35 121.0 0.4 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain DUF3361 PF11841.8 EDN04021.1 - 3.4e-15 56.3 0.0 9.7e-15 54.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) APH PF01636.23 EDN04023.1 - 0.00011 22.2 0.1 0.00023 21.2 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family SUI1 PF01253.22 EDN04024.1 - 1.7e-25 89.3 1.3 2.5e-25 88.8 0.4 1.7 2 0 0 2 2 2 1 Translation initiation factor SUI1 Img2 PF05046.14 EDN04024.1 - 0.055 13.8 0.4 0.11 12.8 0.4 1.5 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Pox_L3_FP4 PF03339.14 EDN04024.1 - 0.094 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein Spt20 PF12090.8 EDN04025.1 - 0.0091 15.6 22.6 0.0091 15.6 22.6 1.6 2 0 0 2 2 2 1 Spt20 family Fes1 PF08609.10 EDN04025.1 - 2.7 8.9 6.6 4.3 8.3 3.2 2.6 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 RskA PF10099.9 EDN04025.1 - 3.3 8.0 7.7 22 5.3 3.1 2.6 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Cgr1 PF03879.14 EDN04026.1 - 2.7e-34 117.8 28.7 3.1e-34 117.6 28.7 1.0 1 0 0 1 1 1 1 Cgr1 family DUF572 PF04502.13 EDN04026.1 - 0.13 11.9 14.9 0.15 11.7 14.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) RRT14 PF17075.5 EDN04026.1 - 0.52 10.4 13.7 0.69 10.0 13.7 1.1 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 Ndufs5 PF10200.9 EDN04026.1 - 1.8 8.8 8.7 4.2 7.7 8.4 1.8 1 1 1 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Mito_carr PF00153.27 EDN04027.1 - 3.6e-62 206.3 0.3 9.2e-20 70.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein dCMP_cyt_deam_1 PF00383.23 EDN04028.1 - 7.1e-15 54.7 0.9 9e-15 54.4 0.9 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EDN04028.1 - 1.1e-10 41.9 3.3 3.2e-08 33.9 0.6 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EDN04028.1 - 0.028 14.0 3.7 0.24 11.0 0.1 2.1 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases Kdo PF06293.14 EDN04030.1 - 0.0025 17.2 0.1 0.005 16.2 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN04030.1 - 0.0086 16.0 0.1 0.014 15.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN04030.1 - 0.0092 15.6 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EDN04030.1 - 0.085 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EDN04030.1 - 0.14 11.5 0.1 0.22 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein kinase domain LPD22 PF18834.1 EDN04031.1 - 0.059 13.6 2.5 0.12 12.6 2.5 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 DUF16 PF01519.16 EDN04031.1 - 0.28 11.7 1.9 0.51 10.9 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4192 PF13830.6 EDN04031.1 - 1.6 8.7 6.7 2.7 8.0 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Sortilin-Vps10 PF15902.5 EDN04034.1 - 3e-291 965.6 11.4 4.6e-156 520.1 0.0 3.1 2 1 1 3 3 3 3 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EDN04034.1 - 2.5e-65 219.9 2.2 2.7e-47 161.3 2.2 3.3 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EDN04034.1 - 2.5e-12 44.8 32.4 0.54 10.5 0.2 12.0 12 0 0 12 12 12 6 BNR/Asp-box repeat CHB_HEX_C PF03174.13 EDN04034.1 - 0.041 13.9 0.1 14 5.7 0.0 3.6 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain Mo-co_dimer PF03404.16 EDN04034.1 - 0.042 13.9 0.3 28 4.7 0.0 4.6 4 0 0 4 4 4 0 Mo-co oxidoreductase dimerisation domain BNR_6 PF15899.5 EDN04034.1 - 0.049 13.7 12.0 2.2 8.6 0.0 6.1 7 0 0 7 7 7 0 BNR-Asp box repeat Adeno_E3_CR2 PF02439.15 EDN04034.1 - 2.2 8.1 4.6 5.6 6.8 4.6 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 PI3K_1B_p101 PF10486.9 EDN04035.1 - 0.14 9.9 2.7 0.13 10.0 2.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PNISR PF15996.5 EDN04035.1 - 0.15 12.3 2.1 0.21 11.9 2.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SR-25 PF10500.9 EDN04035.1 - 0.64 9.6 9.6 0.83 9.2 9.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIS_M PF07500.14 EDN04036.1 - 8.2e-30 103.6 1.4 9.7e-30 103.3 0.4 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EDN04036.1 - 3.1e-14 52.5 3.1 7.5e-14 51.3 3.1 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EDN04036.1 - 6.7e-13 48.5 0.6 1.4e-12 47.5 0.6 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zf-LITAF-like PF10601.9 EDN04036.1 - 0.05 13.9 3.1 0.11 12.8 3.1 1.4 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Fungal_trans PF04082.18 EDN04038.1 - 5.8e-17 61.6 0.0 7.6e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN04038.1 - 8e-08 32.3 13.6 1.6e-07 31.3 13.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_capsid PF06112.11 EDN04039.1 - 3.2 7.8 6.7 1 9.4 0.1 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Sec10 PF07393.11 EDN04040.1 - 1.5e-233 777.3 0.0 1.8e-233 777.1 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 Baculo_PEP_C PF04513.12 EDN04040.1 - 0.91 9.6 3.7 67 3.5 1.8 3.6 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus LRR_6 PF13516.6 EDN04041.1 - 5e-10 38.6 1.4 0.017 15.2 0.2 5.9 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 EDN04041.1 - 0.00039 20.7 4.5 4.8 7.8 0.0 6.2 4 2 3 7 7 7 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDN04041.1 - 0.001 18.7 2.7 2.7 7.8 0.0 4.8 4 1 0 4 4 4 2 Leucine rich repeat COPI_C PF06957.11 EDN04041.1 - 4.1 6.0 8.3 6.6 5.4 8.3 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus YgaB PF14182.6 EDN04041.1 - 9.9 6.6 11.4 0.33 11.4 3.0 2.7 2 0 0 2 2 2 0 YgaB-like protein RRM_1 PF00076.22 EDN04043.1 - 1.7e-39 133.4 0.0 1.8e-18 66.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN04043.1 - 0.0023 18.0 0.0 0.67 10.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.5 EDN04043.1 - 0.053 13.4 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif OapA PF04225.12 EDN04043.1 - 0.16 12.1 0.6 0.28 11.3 0.6 1.4 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain Alg6_Alg8 PF03155.15 EDN04044.1 - 1.6e-126 423.2 27.9 2.3e-125 419.4 27.9 2.1 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family HNH_2 PF13391.6 EDN04047.1 - 2.8e-08 33.8 0.3 9.5e-08 32.1 0.2 2.0 1 1 0 1 1 1 1 HNH endonuclease Pkinase PF00069.25 EDN04048.1 - 2.2e-21 76.4 0.0 1.4e-10 41.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN04048.1 - 9e-10 38.3 1.7 0.00095 18.5 0.1 3.5 3 1 0 3 3 3 2 Protein tyrosine kinase Kri1_C PF12936.7 EDN04048.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 KRI1-like family C-terminal Kdo PF06293.14 EDN04048.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pex19 PF04614.12 EDN04050.1 - 2e-71 240.6 1.7 2.8e-71 240.1 0.0 1.8 2 0 0 2 2 2 1 Pex19 protein family Radial_spoke_3 PF06098.11 EDN04050.1 - 0.011 15.0 0.1 0.019 14.2 0.1 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 Stm1_N PF09598.10 EDN04052.1 - 5.4e-14 52.8 4.5 5.4e-14 52.8 4.5 4.7 2 1 1 3 3 3 1 Stm1 API5 PF05918.11 EDN04052.1 - 2.4 6.9 8.8 51 2.5 0.0 2.2 2 1 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) DUF4965 PF16335.5 EDN04053.1 - 3.5e-56 189.6 0.3 2.9e-50 170.3 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EDN04053.1 - 2e-42 145.5 0.1 2.8e-42 145.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) tRNA-synt_1c PF00749.21 EDN04054.1 - 1.5e-91 306.6 0.0 2.8e-91 305.7 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDN04054.1 - 3e-31 108.6 0.0 5e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_2 PF13410.6 EDN04054.1 - 0.008 16.2 0.1 0.024 14.7 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDN04054.1 - 0.02 15.0 0.0 0.19 11.9 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDN04054.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Helicase_C PF00271.31 EDN04057.1 - 1.2e-31 109.3 0.1 4.2e-31 107.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN04057.1 - 6.1e-18 65.2 0.0 4.4e-17 62.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase HCO3_cotransp PF00955.21 EDN04058.1 - 5e-74 249.9 12.5 2.8e-45 155.1 6.0 3.1 1 1 2 3 3 3 3 HCO3- transporter family BCHF PF07284.11 EDN04058.1 - 0.0065 16.5 0.2 0.019 15.0 0.2 1.8 1 0 0 1 1 1 1 2-vinyl bacteriochlorophyllide hydratase (BCHF) DUF4231 PF14015.6 EDN04058.1 - 0.27 11.7 2.5 0.28 11.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) SF1-HH PF16275.5 EDN04059.1 - 3.5e-43 146.5 0.8 7.8e-43 145.4 0.8 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EDN04059.1 - 2.7e-08 33.5 0.1 5e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 EDN04059.1 - 0.084 13.0 0.4 0.17 12.0 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle NAD_binding_6 PF08030.12 EDN04060.1 - 3.7e-17 62.9 0.0 2.2e-14 53.8 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDN04060.1 - 1.4e-14 54.0 0.0 3.5e-09 36.7 0.0 2.6 2 0 0 2 2 2 2 FAD-binding domain Ferric_reduct PF01794.19 EDN04060.1 - 2.5e-09 37.3 14.5 1.3e-06 28.6 4.6 3.3 3 1 1 4 4 4 2 Ferric reductase like transmembrane component DUF1206 PF06724.11 EDN04060.1 - 0.0076 16.3 3.5 0.15 12.1 0.0 3.7 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1206) MnhB PF04039.13 EDN04060.1 - 0.69 10.2 5.7 24 5.3 0.0 3.3 4 0 0 4 4 4 0 Domain related to MnhB subunit of Na+/H+ antiporter BCS1_N PF08740.11 EDN04061.1 - 1.1e-23 84.2 0.6 1.4e-20 74.1 0.0 2.4 1 1 1 2 2 2 2 BCS1 N terminal AAA PF00004.29 EDN04061.1 - 3.9e-11 43.5 0.3 1.5e-10 41.6 0.3 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Bac_export_2 PF01312.19 EDN04061.1 - 0.11 11.6 0.2 0.16 11.1 0.2 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family RNA_pol_Rpb4 PF03874.16 EDN04062.1 - 0.026 14.8 0.0 0.032 14.5 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb4 DUF3619 PF12279.8 EDN04062.1 - 0.076 13.3 0.4 0.1 12.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Pkinase PF00069.25 EDN04064.1 - 4.2e-12 46.0 0.0 5.1e-11 42.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN04064.1 - 4.8e-07 29.3 0.0 8.3e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN04064.1 - 0.0016 17.3 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase UQ_con PF00179.26 EDN04065.1 - 9e-41 138.8 0.0 1e-40 138.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN04065.1 - 8.5e-07 28.7 0.0 1.2e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDN04065.1 - 0.036 14.3 0.1 0.047 14.0 0.1 1.4 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EDN04065.1 - 0.097 12.5 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain Peptidase_S24 PF00717.23 EDN04066.1 - 1.6e-07 31.2 0.1 2.6e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like BTB PF00651.31 EDN04069.1 - 6.2e-05 23.2 0.0 0.00029 21.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.15 EDN04069.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain LprI PF07007.12 EDN04070.1 - 0.12 13.0 0.1 0.17 12.5 0.1 1.3 1 0 0 1 1 1 0 Lysozyme inhibitor LprI RT_RNaseH PF17917.1 EDN04071.1 - 1.6e-34 118.3 0.0 7e-34 116.3 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN04071.1 - 4.2e-32 111.5 0.1 7.2e-32 110.7 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN04071.1 - 1.3e-23 82.9 0.1 1.8e-12 47.1 0.0 2.9 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN04071.1 - 3.2e-19 68.8 0.2 8.1e-19 67.5 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN04071.1 - 2.6e-15 56.7 0.0 8.2e-15 55.0 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN04071.1 - 4.8e-14 52.0 1.4 1.4e-13 50.5 1.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN04071.1 - 1.8e-05 24.8 0.1 4e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Retrotrans_gag PF03732.17 EDN04071.1 - 0.00042 20.5 2.2 0.00042 20.5 2.2 2.9 2 0 0 2 2 2 1 Retrotransposon gag protein Mtf2_C PF14061.6 EDN04071.1 - 0.037 14.2 0.9 0.43 10.8 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 Retrotran_gag_2 PF14223.6 EDN04071.1 - 0.36 10.5 1.6 0.9 9.2 1.6 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Aminotran_1_2 PF00155.21 EDN04072.1 - 1.8e-82 277.5 0.0 2.4e-82 277.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDN04072.1 - 6.8e-06 24.9 0.0 1.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EDN04072.1 - 1.3e-05 24.7 0.0 2.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EDN04072.1 - 0.00011 21.4 0.0 0.00017 20.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDN04072.1 - 0.0012 18.2 0.2 0.0033 16.8 0.1 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase RNA_pol_I_A49 PF06870.12 EDN04073.1 - 5.4e-69 232.9 0.0 2.9e-44 151.5 0.0 2.1 1 1 0 2 2 2 2 A49-like RNA polymerase I associated factor NBP1 PF08537.10 EDN04073.1 - 0.065 12.7 0.7 0.28 10.6 0.1 1.9 1 1 1 2 2 2 0 Fungal Nap binding protein NBP1 GATase PF00117.28 EDN04074.1 - 1.7e-46 158.4 0.0 2.2e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EDN04074.1 - 1.3e-44 151.2 0.0 2.4e-44 150.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 EDN04074.1 - 0.00015 21.6 0.3 0.0025 17.6 0.1 2.4 1 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 EDN04074.1 - 0.022 14.6 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Peptidase_S10 PF00450.22 EDN04075.1 - 9.8e-48 163.6 0.0 1.8e-47 162.7 0.0 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.22 EDN04076.1 - 2.4e-10 40.4 0.0 3e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Thump_like PF18096.1 EDN04076.1 - 0.057 13.3 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 THUMP domain-like Goodbye PF17109.5 EDN04077.1 - 6.5e-06 26.6 8.0 3.8e-05 24.1 0.1 3.5 3 1 1 4 4 4 2 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EDN04077.1 - 0.007 16.8 0.0 0.056 13.8 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EDN04077.1 - 0.051 14.0 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Met_synt_B12 PF02965.17 EDN04077.1 - 0.063 12.7 2.3 0.26 10.7 0.1 2.7 3 0 0 3 3 3 0 Vitamin B12 dependent methionine synthase, activation domain DUF3825 PF12873.7 EDN04077.1 - 0.065 12.7 0.0 0.25 10.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3825) RuvB_N PF05496.12 EDN04077.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TPR_1 PF00515.28 EDN04077.1 - 0.16 11.9 0.0 0.6 10.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat ZZ PF00569.17 EDN04077.1 - 0.21 11.4 13.4 0.28 11.0 10.8 2.2 2 0 0 2 2 2 0 Zinc finger, ZZ type NIF PF03031.18 EDN04078.1 - 9.4e-53 178.2 0.0 1.1e-52 178.0 0.0 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase p450 PF00067.22 EDN04079.1 - 1.4e-47 162.5 0.0 1.7e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SP2 PF03014.14 EDN04079.1 - 0.087 11.2 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 Structural protein 2 DIT1_PvcA PF05141.12 EDN04080.1 - 5e-83 278.8 0.0 6.9e-83 278.3 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein IF-2B PF01008.17 EDN04081.1 - 1.1e-52 179.1 0.2 2e-37 128.9 0.0 2.0 2 0 0 2 2 2 2 Initiation factor 2 subunit family 3HCDH_N PF02737.18 EDN04081.1 - 0.1 12.5 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosom_S12_S23 PF00164.25 EDN04082.1 - 1e-50 170.1 0.7 1.2e-50 169.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 EDN04083.1 - 1.3e-22 79.4 2.5 2.4e-22 78.5 2.5 1.5 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) Keratin_2_head PF16208.5 EDN04083.1 - 3.1 7.9 23.3 4.6 7.4 4.2 2.3 2 0 0 2 2 2 0 Keratin type II head Ribosomal_L17 PF01196.19 EDN04084.1 - 8.4e-31 106.7 0.0 1.5e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L17 Cwf_Cwc_15 PF04889.12 EDN04084.1 - 2.6 7.7 9.1 13 5.5 4.6 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SUZ PF12752.7 EDN04085.1 - 1.2e-15 58.0 9.6 1.2e-15 58.0 9.6 3.7 5 1 0 5 5 5 1 SUZ domain R3H PF01424.22 EDN04085.1 - 5.3e-06 26.3 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 R3H domain zf-CCHC_3 PF13917.6 EDN04086.1 - 1.6e-06 27.9 0.6 3.2e-06 27.0 0.6 1.5 1 0 0 1 1 1 1 Zinc knuckle cwf18 PF08315.12 EDN04087.1 - 5.9e-44 150.0 5.1 5.9e-44 150.0 5.1 1.9 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor PPR_2 PF13041.6 EDN04088.1 - 6.4e-10 39.1 0.0 0.00048 20.3 0.0 4.5 5 0 0 5 5 5 2 PPR repeat family PPR_3 PF13812.6 EDN04088.1 - 1.2e-07 31.7 0.0 0.011 15.8 0.0 3.0 3 0 0 3 3 3 2 Pentatricopeptide repeat domain MRP-S27 PF10037.9 EDN04088.1 - 7.6e-05 21.7 0.0 0.041 12.7 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial 28S ribosomal protein S27 PPR PF01535.20 EDN04088.1 - 0.0052 17.0 0.0 1.5 9.2 0.0 4.6 6 0 0 6 6 6 1 PPR repeat PPR_1 PF12854.7 EDN04088.1 - 0.052 13.3 0.0 24 4.7 0.0 3.3 3 0 0 3 3 3 0 PPR repeat DUF1242 PF06842.12 EDN04089.1 - 1.5e-12 47.0 0.0 2.7e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) PsbH PF00737.20 EDN04089.1 - 0.56 10.0 3.3 18 5.1 1.2 2.2 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein TFIID-18kDa PF02269.16 EDN04090.1 - 3.8e-14 52.5 0.0 6.6e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 EDN04090.1 - 0.0073 16.7 0.1 0.014 15.7 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EDN04090.1 - 0.013 15.6 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) TFIID_20kDa PF03847.13 EDN04090.1 - 0.083 13.4 0.1 0.14 12.7 0.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A JAB PF01398.21 EDN04091.1 - 4.7e-20 71.7 0.0 7.7e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDN04091.1 - 2.3e-19 69.9 0.2 4.1e-19 69.1 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EDN04091.1 - 5.4e-05 23.3 0.0 0.00016 21.8 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) UTP25 PF06862.12 EDN04092.1 - 1.2e-201 670.6 0.0 1.7e-201 670.1 0.0 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EDN04092.1 - 0.0022 17.8 0.3 0.092 12.5 0.3 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase EamA PF00892.20 EDN04093.1 - 1.3e-15 57.8 31.1 3.1e-09 37.1 7.0 3.1 3 0 0 3 3 3 3 EamA-like transporter family CTP_transf_like PF01467.26 EDN04094.1 - 2e-23 83.2 0.0 3.9e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Arena_RNA_pol PF06317.11 EDN04094.1 - 0.33 8.1 0.0 0.42 7.7 0.0 1.0 1 0 0 1 1 1 0 Arenavirus RNA polymerase PP2C PF00481.21 EDN04095.1 - 2.5e-25 89.6 5.9 1.5e-14 54.3 0.4 2.9 2 1 1 3 3 3 2 Protein phosphatase 2C YL1 PF05764.13 EDN04095.1 - 0.0063 16.7 7.5 0.0063 16.7 7.5 1.6 2 0 0 2 2 2 1 YL1 nuclear protein Nop14 PF04147.12 EDN04095.1 - 0.014 13.7 9.2 0.018 13.3 9.2 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EDN04095.1 - 0.14 10.4 10.5 0.18 10.0 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3665 PF12427.8 EDN04095.1 - 0.27 10.9 0.7 0.56 9.9 0.7 1.4 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase NOA36 PF06524.12 EDN04095.1 - 1.4 8.2 8.4 2.3 7.5 8.4 1.3 1 0 0 1 1 1 0 NOA36 protein Lin-8 PF03353.15 EDN04095.1 - 1.7 8.1 7.1 2.5 7.6 7.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Sporozoite_P67 PF05642.11 EDN04095.1 - 2.2 6.3 10.5 2.9 5.8 10.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SDA1 PF05285.12 EDN04095.1 - 3.2 7.1 14.9 4.6 6.6 14.9 1.1 1 0 0 1 1 1 0 SDA1 TipE PF16972.5 EDN04095.1 - 4.1 6.5 7.6 5.7 6.0 7.6 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE CENP-B_dimeris PF09026.10 EDN04095.1 - 5.7 7.4 14.0 11 6.5 14.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain eIF-3c_N PF05470.12 EDN04095.1 - 6 5.0 7.2 8.1 4.6 7.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Hid1 PF12722.7 EDN04095.1 - 9.7 4.2 6.8 13 3.7 6.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Acetyltransf_7 PF13508.7 EDN04096.1 - 3.3e-08 33.8 0.3 6.3e-08 32.9 0.1 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN04096.1 - 6.6e-08 32.8 0.1 1.1e-07 32.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN04096.1 - 0.00026 21.0 0.2 0.00041 20.3 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDN04096.1 - 0.0018 18.4 0.0 0.0029 17.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EDN04096.1 - 0.012 15.5 0.1 0.024 14.6 0.1 1.5 1 1 0 1 1 1 0 FR47-like protein PanZ PF12568.8 EDN04096.1 - 0.024 14.4 0.2 0.048 13.4 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ MOZART1 PF12554.8 EDN04097.1 - 1.1e-23 82.7 1.1 1.5e-23 82.3 1.1 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated HGD-D PF06050.13 EDN04097.1 - 0.092 12.5 0.1 0.22 11.2 0.0 1.6 1 1 1 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component DUF5101 PF17031.5 EDN04097.1 - 0.1 12.7 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) HA2 PF04408.23 EDN04099.1 - 1.8e-13 50.7 0.0 4.3e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDN04099.1 - 1.9e-13 50.5 0.0 4e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDN04099.1 - 3.3e-13 49.9 0.0 7.6e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDN04099.1 - 3.4e-05 24.1 0.0 0.00011 22.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN04099.1 - 0.00014 21.6 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EDN04099.1 - 0.00017 21.4 0.1 0.00041 20.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EDN04099.1 - 0.0012 19.1 0.0 0.0064 16.8 0.0 2.0 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 EDN04099.1 - 0.0037 16.9 0.1 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EDN04099.1 - 0.013 14.5 0.1 0.035 13.2 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Herpes_ori_bp PF02399.15 EDN04099.1 - 0.03 12.4 0.0 0.044 11.8 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein AAA_14 PF13173.6 EDN04099.1 - 0.056 13.5 0.1 8 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EDN04099.1 - 0.12 11.3 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 EDN04099.1 - 0.15 11.3 0.4 0.48 9.7 0.1 1.9 1 1 1 2 2 2 0 Zeta toxin AAA_33 PF13671.6 EDN04099.1 - 0.16 12.1 0.2 1 9.5 0.2 2.2 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EDN04099.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PITH PF06201.13 EDN04100.1 - 5.9e-43 146.7 0.0 7.2e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 PITH domain BofC_C PF08955.10 EDN04100.1 - 0.099 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 BofC C-terminal domain Snf7 PF03357.21 EDN04101.1 - 1.2e-30 106.3 6.8 1.2e-30 106.3 6.8 1.8 1 1 1 2 2 2 1 Snf7 Silic_transp PF03842.13 EDN04101.1 - 0.14 10.4 0.4 0.2 9.9 0.4 1.2 1 0 0 1 1 1 0 Silicon transporter AAA PF00004.29 EDN04102.1 - 8.2e-86 285.1 0.0 5e-44 149.9 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN04102.1 - 2.8e-14 53.9 0.6 7.1e-05 23.3 0.1 4.1 2 2 0 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 EDN04102.1 - 4.3e-14 52.6 0.0 1.4e-06 28.1 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 EDN04102.1 - 2.8e-13 49.4 0.1 1.1e-08 34.7 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_22 PF13401.6 EDN04102.1 - 5.4e-13 49.4 0.6 0.0083 16.4 0.0 5.6 4 2 2 6 6 4 2 AAA domain AAA_2 PF07724.14 EDN04102.1 - 2.5e-11 44.0 0.0 4.7e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDN04102.1 - 4.3e-11 43.0 0.2 0.00057 19.9 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDN04102.1 - 4.1e-10 40.0 0.0 0.00016 21.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDN04102.1 - 6.4e-09 35.5 0.0 0.00014 21.2 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 EDN04102.1 - 6.2e-08 33.0 0.0 0.0053 17.1 0.0 2.7 2 1 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EDN04102.1 - 1.4e-07 31.6 0.0 0.0062 16.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EDN04102.1 - 3.9e-07 29.7 0.5 0.021 14.2 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDN04102.1 - 6e-07 29.4 0.1 0.047 13.4 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 EDN04102.1 - 7e-07 29.6 0.0 0.016 15.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 EDN04102.1 - 1.2e-06 28.4 0.0 0.0043 16.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDN04102.1 - 1.6e-06 27.5 0.0 0.062 12.6 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_18 PF13238.6 EDN04102.1 - 1.6e-06 28.7 0.0 0.045 14.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 EDN04102.1 - 3.8e-06 26.9 0.0 0.053 13.5 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EDN04102.1 - 8e-06 25.9 0.2 0.13 12.1 0.0 3.4 3 1 1 4 4 3 2 NACHT domain Cytidylate_kin2 PF13189.6 EDN04102.1 - 1.3e-05 25.5 0.0 0.0033 17.6 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_25 PF13481.6 EDN04102.1 - 1.5e-05 24.7 0.7 1.2 8.7 0.0 3.6 2 1 0 3 3 3 2 AAA domain Rad17 PF03215.15 EDN04102.1 - 1.8e-05 24.8 0.0 0.11 12.5 0.0 2.7 3 0 0 3 3 2 2 Rad17 P-loop domain ATPase PF06745.13 EDN04102.1 - 3e-05 23.5 0.2 0.69 9.2 0.0 3.4 3 1 0 4 4 4 2 KaiC AAA_7 PF12775.7 EDN04102.1 - 3.7e-05 23.3 0.0 0.13 11.7 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region TniB PF05621.11 EDN04102.1 - 7.3e-05 22.3 0.0 0.08 12.3 0.0 3.4 3 0 0 3 3 3 1 Bacterial TniB protein ABC_tran PF00005.27 EDN04102.1 - 7.5e-05 23.3 0.0 0.46 11.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Sigma54_activat PF00158.26 EDN04102.1 - 9.7e-05 22.1 0.0 0.31 10.7 0.0 2.9 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.6 EDN04102.1 - 0.0002 21.8 0.0 0.28 11.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.16 EDN04102.1 - 0.00031 19.8 0.0 0.08 11.8 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase PhoH PF02562.16 EDN04102.1 - 0.00055 19.4 0.0 0.73 9.2 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_11 PF13086.6 EDN04102.1 - 0.00061 19.7 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain SKI PF01202.22 EDN04102.1 - 0.00074 19.7 0.0 0.73 9.9 0.0 2.6 2 0 0 2 2 2 1 Shikimate kinase AAA_24 PF13479.6 EDN04102.1 - 0.00085 19.1 0.0 0.89 9.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 EDN04102.1 - 0.00096 18.3 0.0 1.3 8.1 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 EDN04102.1 - 0.0012 18.9 0.0 2.5 8.2 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain NB-ARC PF00931.22 EDN04102.1 - 0.0014 17.9 0.0 0.96 8.6 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 EDN04102.1 - 0.0014 18.6 0.1 1.8 8.4 0.0 3.6 3 2 1 4 4 3 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 EDN04102.1 - 0.0015 17.8 0.0 0.047 12.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 EDN04102.1 - 0.0022 17.8 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EDN04102.1 - 0.017 15.5 2.5 4.7 7.5 0.4 3.2 2 1 0 2 2 2 0 AAA domain CPT PF07931.12 EDN04102.1 - 0.018 14.9 0.0 0.4 10.5 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ResIII PF04851.15 EDN04102.1 - 0.031 14.3 0.0 8.8 6.3 0.0 2.7 2 1 1 3 3 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EDN04102.1 - 0.04 13.1 0.0 3.5 6.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EDN04102.1 - 0.041 13.8 0.1 6.5 6.6 0.0 2.9 2 1 1 3 3 3 0 NTPase Vps4_C PF09336.10 EDN04102.1 - 0.072 13.1 0.1 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain IPT PF01745.16 EDN04102.1 - 0.089 12.2 0.1 8.5 5.7 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_30 PF13604.6 EDN04102.1 - 0.11 12.2 0.3 18 5.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain Cytidylate_kin PF02224.18 EDN04102.1 - 0.14 11.8 0.1 12 5.6 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase AAA_23 PF13476.6 EDN04102.1 - 0.16 12.5 0.1 4.8 7.6 0.0 2.7 3 0 0 3 3 2 0 AAA domain BOP1NT PF08145.12 EDN04103.1 - 1.6e-102 342.9 4.3 2.9e-102 342.0 4.3 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EDN04103.1 - 4.7e-22 77.9 6.3 6.3e-09 36.3 0.2 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04103.1 - 3.7e-07 30.3 0.0 0.0052 17.1 0.0 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain VHL PF01847.16 EDN04103.1 - 0.14 12.1 0.1 0.71 9.8 0.1 2.1 2 0 0 2 2 2 0 VHL beta domain Frtz PF11768.8 EDN04103.1 - 0.15 10.3 0.0 0.92 7.7 0.0 2.0 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Zn_clus PF00172.18 EDN04104.1 - 2.6e-09 37.1 6.6 5.4e-09 36.0 6.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Leo1 PF04004.13 EDN04105.1 - 3e-29 102.0 1.3 1.4e-28 99.8 1.3 2.0 1 1 0 1 1 1 1 Leo1-like protein Rhomboid PF01694.22 EDN04106.1 - 8.9e-14 51.7 1.2 1.7e-13 50.8 1.2 1.4 1 0 0 1 1 1 1 Rhomboid family DUF2157 PF09925.9 EDN04106.1 - 0.0054 16.5 0.1 0.014 15.1 0.1 1.7 1 1 0 1 1 1 1 Predicted membrane protein (DUF2157) PhoD PF09423.10 EDN04107.1 - 0.00016 20.8 0.2 0.00024 20.3 0.2 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase Gryzun PF07919.12 EDN04108.1 - 1.6e-243 809.8 0.0 2.1e-243 809.5 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EDN04108.1 - 2.9e-75 253.2 0.0 5.6e-75 252.3 0.0 1.5 1 1 0 1 1 1 1 Foie gras liver health family 1 Ig_3 PF13927.6 EDN04108.1 - 0.06 13.9 0.7 3.1 8.5 0.1 3.1 2 1 0 2 2 2 0 Immunoglobulin domain Gryzun-like PF12742.7 EDN04108.1 - 0.12 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking Abhydrolase_1 PF00561.20 EDN04109.1 - 1.5e-06 28.1 0.0 3.2e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN04109.1 - 0.00046 19.5 0.0 0.006 15.9 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 RTA1 PF04479.13 EDN04110.1 - 1.4e-36 126.1 0.2 1.4e-36 126.1 0.2 1.8 1 1 1 2 2 2 1 RTA1 like protein HTH_33 PF13592.6 EDN04113.1 - 3.1e-08 33.1 0.0 1.3e-07 31.2 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix HTH_7 PF02796.15 EDN04113.1 - 2.8e-06 27.3 0.0 7e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 EDN04113.1 - 8.4e-06 25.5 0.0 0.00013 21.6 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 EDN04113.1 - 9.6e-06 25.3 0.2 0.00041 20.1 0.1 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EDN04113.1 - 1.6e-05 24.8 0.1 0.00015 21.7 0.1 2.0 2 0 0 2 2 2 1 Winged helix-turn helix PAX PF00292.18 EDN04113.1 - 0.0044 17.0 0.0 0.0068 16.3 0.0 1.3 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN04113.1 - 0.022 15.3 0.0 2.5 8.8 0.0 2.2 1 1 1 2 2 2 0 Homeodomain-like domain Terminase_5 PF06056.12 EDN04113.1 - 0.029 14.3 0.1 0.079 12.9 0.0 1.8 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_28 PF13518.6 EDN04113.1 - 0.088 13.0 0.0 9.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Glutaredoxin PF00462.24 EDN04115.1 - 6.4e-13 48.7 0.0 2.4e-12 46.9 0.0 2.0 3 0 0 3 3 3 1 Glutaredoxin TraF PF13728.6 EDN04115.1 - 0.079 12.8 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein GST_N_3 PF13417.6 EDN04115.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Ribosomal_L6 PF00347.23 EDN04116.1 - 9.7e-09 35.8 0.0 1.4e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L6 DUF3336 PF11815.8 EDN04117.1 - 4.5e-33 113.9 0.0 8.5e-33 113.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDN04117.1 - 1e-13 52.0 0.1 2.5e-13 50.7 0.1 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase RXT2_N PF08595.11 EDN04118.1 - 1.5e-43 148.5 0.3 1.5e-43 148.5 0.3 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal PEMT PF04191.13 EDN04119.1 - 6.2e-27 94.1 3.3 1.3e-26 93.0 3.3 1.6 1 0 0 1 1 1 1 Phospholipid methyltransferase PXA PF02194.15 EDN04120.1 - 9.9e-48 162.5 0.2 5.6e-47 160.1 0.0 2.5 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EDN04120.1 - 6.1e-23 81.5 0.0 2.1e-22 79.8 0.0 2.0 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EDN04120.1 - 9e-17 61.1 1.3 2.7e-16 59.6 1.3 1.8 1 0 0 1 1 1 1 PX domain RGS PF00615.19 EDN04120.1 - 1.6e-06 28.4 0.0 4.6e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Serglycin PF04360.12 EDN04120.1 - 0.0028 17.6 0.9 0.085 12.8 0.1 2.5 2 0 0 2 2 2 1 Serglycin LRR19-TM PF15176.6 EDN04120.1 - 1.9 8.5 4.3 16 5.5 0.1 3.9 4 0 0 4 4 4 0 Leucine-rich repeat family 19 TM domain WD40 PF00400.32 EDN04121.1 - 3.6e-18 65.6 4.0 0.00025 21.8 0.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04121.1 - 2.6e-05 24.5 0.0 0.24 11.7 0.0 4.9 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN04121.1 - 0.019 13.9 0.3 0.16 10.9 0.0 2.5 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDN04121.1 - 0.039 12.6 0.1 0.13 10.9 0.0 1.9 2 0 0 2 2 2 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EDN04121.1 - 0.052 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain tRNA-synt_1g PF09334.11 EDN04123.1 - 2.2e-143 477.7 0.0 2.8e-143 477.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDN04123.1 - 1.6e-05 23.4 0.1 0.019 13.2 0.0 3.1 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Elongin_A PF06881.11 EDN04123.1 - 6.5e-05 23.4 1.4 0.00017 22.1 0.5 2.0 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF4090 PF13319.6 EDN04123.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) PepSY PF03413.19 EDN04123.1 - 0.63 10.6 2.8 1.1 9.9 0.0 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain zf-ribbon_3 PF13248.6 EDN04123.1 - 4.6 6.8 5.5 8.1 6.0 0.4 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Yae1_N PF09811.9 EDN04124.1 - 1.8e-09 37.1 4.7 3.7e-09 36.1 4.7 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal ICE2 PF08426.10 EDN04125.1 - 6.9e-160 532.6 9.8 8.3e-160 532.3 9.8 1.1 1 0 0 1 1 1 1 ICE2 Endosulfine PF04667.17 EDN04126.1 - 6.9e-09 35.7 0.1 1.6e-08 34.5 0.1 1.6 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Peptidase_S10 PF00450.22 EDN04128.1 - 6.7e-114 381.5 0.0 8.8e-114 381.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase WD40 PF00400.32 EDN04129.1 - 6.2e-26 90.1 25.3 1.2e-06 29.1 0.3 8.6 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04129.1 - 5.2e-10 39.5 3.2 0.033 14.5 0.0 4.5 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain NifU PF01106.17 EDN04129.1 - 0.041 14.0 0.2 0.47 10.7 0.1 2.6 3 0 0 3 3 3 0 NifU-like domain Tcp11 PF05794.13 EDN04130.1 - 2.4e-102 343.3 0.1 2.4e-102 343.3 0.1 2.3 2 0 0 2 2 2 1 T-complex protein 11 UPF0242 PF06785.11 EDN04130.1 - 4.6 7.3 11.7 12 5.9 11.7 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DIT1_PvcA PF05141.12 EDN04130.1 - 8.2 5.8 9.5 16 4.8 9.5 1.4 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein AtuA PF07287.11 EDN04131.1 - 3.3e-62 210.2 0.0 6.5e-42 143.5 0.0 2.1 1 1 1 2 2 2 2 Acyclic terpene utilisation family protein AtuA HMA PF00403.26 EDN04132.1 - 3.3e-15 56.3 0.2 4e-15 56.0 0.2 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain BAT PF15915.5 EDN04132.1 - 0.033 14.1 0.0 0.039 13.8 0.0 1.1 1 0 0 1 1 1 0 GAF and HTH_10 associated domain Fer2_BFD PF04324.15 EDN04132.1 - 0.095 13.1 0.2 0.23 11.8 0.2 1.6 1 1 0 1 1 1 0 BFD-like [2Fe-2S] binding domain DUF2293 PF10056.9 EDN04133.1 - 1.6e-29 102.0 0.3 1.6e-29 102.0 0.3 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) Complex1_LYR PF05347.15 EDN04136.1 - 0.014 15.5 0.3 0.023 14.7 0.3 1.4 1 0 0 1 1 1 0 Complex 1 protein (LYR family) zinc_ribbon_6 PF14599.6 EDN04137.1 - 3.8e-24 84.5 0.7 3.8e-24 84.5 0.7 4.6 4 0 0 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 EDN04137.1 - 1.2e-17 64.1 21.7 1.2e-17 64.1 21.7 3.9 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EDN04137.1 - 3.9e-09 36.7 7.7 3.9e-09 36.7 7.7 5.3 2 1 3 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDN04137.1 - 1e-06 28.5 6.6 1e-06 28.5 6.6 4.9 4 1 2 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN04137.1 - 1.1e-05 25.2 6.3 1.1e-05 25.2 6.3 6.3 2 2 3 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDN04137.1 - 1.4e-05 24.9 8.7 1.4e-05 24.9 8.7 6.6 5 4 1 6 6 6 1 zinc-RING finger domain Rrn6 PF10214.9 EDN04138.1 - 2.2e-113 380.5 2.1 3.1e-88 297.3 3.6 2.0 1 1 1 2 2 2 2 RNA polymerase I-specific transcription-initiation factor Spindle_Spc25 PF08234.12 EDN04139.1 - 9.8e-23 80.2 0.1 2.6e-22 78.8 0.0 1.7 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 DUF4614 PF15391.6 EDN04139.1 - 0.011 15.8 1.2 0.022 14.8 1.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4614) Phage_tail_APC PF16778.5 EDN04139.1 - 3 7.8 6.8 5.9 6.8 3.6 2.5 2 1 0 2 2 2 0 Phage tail assembly chaperone protein WD40 PF00400.32 EDN04140.1 - 3.4e-19 68.8 15.2 4.3e-08 33.7 0.6 6.1 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04140.1 - 4e-12 46.3 1.7 4.7e-06 26.8 0.2 4.4 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN04140.1 - 0.0013 17.8 0.0 0.052 12.5 0.0 2.7 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EDN04140.1 - 0.004 16.5 1.2 1.7 7.9 0.0 3.2 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.11 EDN04140.1 - 0.023 14.6 0.0 0.097 12.5 0.0 2.0 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Septin PF00735.18 EDN04141.1 - 5.9e-112 373.5 0.4 7.1e-112 373.3 0.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EDN04141.1 - 1.8e-07 31.2 0.0 3.6e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDN04141.1 - 7.8e-06 25.4 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EDN04141.1 - 5.9e-05 23.0 0.2 0.00031 20.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EDN04141.1 - 0.0002 21.0 0.5 0.012 15.1 0.1 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDN04141.1 - 0.00059 19.9 0.3 1.5 8.9 0.0 2.5 1 1 0 2 2 2 2 Dynamin family AAA_16 PF13191.6 EDN04141.1 - 0.0073 16.7 0.0 0.014 15.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EDN04141.1 - 0.0079 15.4 0.1 0.014 14.6 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EDN04141.1 - 0.0087 16.3 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDN04141.1 - 0.01 15.3 0.1 0.049 13.1 0.0 2.1 1 1 1 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 EDN04141.1 - 0.015 15.8 0.7 0.024 15.2 0.7 1.8 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.20 EDN04141.1 - 0.054 12.7 0.3 0.46 9.6 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EDN04141.1 - 0.085 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Gtr1_RagA PF04670.12 EDN04141.1 - 0.11 11.9 0.0 0.89 8.9 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region T2SSE PF00437.20 EDN04141.1 - 0.14 11.2 0.0 0.47 9.5 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 EDN04141.1 - 0.19 11.5 0.0 0.41 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 EDN04142.1 - 4.4e-65 218.8 0.0 5e-65 218.6 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EDN04142.1 - 3.1e-06 27.7 0.1 7.3e-06 26.5 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EDN04142.1 - 3.6e-06 27.2 0.0 2e-05 24.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EDN04142.1 - 3.3e-05 23.9 0.0 5.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EDN04142.1 - 0.00018 21.8 0.0 0.0022 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EDN04142.1 - 0.00036 21.1 0.0 0.00079 19.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EDN04142.1 - 0.00038 20.4 0.0 0.00071 19.5 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 EDN04142.1 - 0.00096 19.7 0.7 0.029 14.9 0.7 2.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDN04142.1 - 0.0013 19.0 0.1 0.0042 17.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDN04142.1 - 0.0036 17.0 0.0 0.009 15.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 EDN04142.1 - 0.0058 17.1 0.0 0.15 12.5 0.0 2.3 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDN04142.1 - 0.0061 16.5 0.0 0.0083 16.1 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain RNA_helicase PF00910.22 EDN04142.1 - 0.01 16.2 0.0 0.014 15.8 0.0 1.5 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EDN04142.1 - 0.012 15.2 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EDN04142.1 - 0.012 15.4 0.0 0.073 12.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EDN04142.1 - 0.012 15.6 0.0 0.027 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 EDN04142.1 - 0.022 14.3 0.0 0.076 12.6 0.0 1.8 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EDN04142.1 - 0.025 15.1 0.6 0.085 13.3 0.0 1.9 2 1 0 2 2 2 0 AAA domain dNK PF01712.19 EDN04142.1 - 0.034 14.0 0.1 0.66 9.8 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase NACHT PF05729.12 EDN04142.1 - 0.037 14.0 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 EDN04142.1 - 0.053 13.4 0.2 0.12 12.3 0.1 1.8 1 1 1 2 2 2 0 NTPase AAA_30 PF13604.6 EDN04142.1 - 0.066 12.9 0.0 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EDN04142.1 - 0.071 12.8 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 EDN04142.1 - 0.075 13.5 0.1 1.4 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EDN04142.1 - 0.087 12.5 0.1 2.2 7.9 0.0 2.5 2 1 1 3 3 3 0 Thymidylate kinase ATPase_2 PF01637.18 EDN04142.1 - 0.098 12.6 0.0 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Gtr1_RagA PF04670.12 EDN04142.1 - 0.22 10.8 0.0 0.45 9.8 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Adeno_IVa2 PF02456.15 EDN04142.1 - 0.25 10.1 0.0 0.38 9.5 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein GRAB PF10375.9 EDN04143.1 - 0.00011 21.9 3.2 0.00049 19.9 3.2 2.1 1 1 0 1 1 1 1 GRIP-related Arf-binding domain BST2 PF16716.5 EDN04143.1 - 0.0053 17.3 10.6 0.0053 17.3 10.6 4.6 1 1 5 6 6 6 1 Bone marrow stromal antigen 2 NPV_P10 PF05531.12 EDN04143.1 - 0.57 10.7 20.3 0.22 12.0 1.6 4.4 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Golgin_A5 PF09787.9 EDN04143.1 - 1.4 8.4 56.4 3.3 7.1 17.7 3.4 1 1 2 3 3 3 0 Golgin subfamily A member 5 FliJ PF02050.16 EDN04143.1 - 2.1 8.6 45.5 2.7 8.2 15.5 3.8 1 1 2 3 3 3 0 Flagellar FliJ protein FAM184 PF15665.5 EDN04143.1 - 2.4 7.9 54.4 5.7 6.7 19.5 3.2 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B KASH_CCD PF14662.6 EDN04143.1 - 2.6 7.8 58.0 0.29 11.0 12.3 2.8 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Fib_alpha PF08702.10 EDN04143.1 - 3.9 7.7 27.6 5.1 7.3 6.9 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EDN04143.1 - 5 6.4 37.7 7.3 5.8 14.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EDN04143.1 - 6.9 6.7 51.7 1.2 9.2 14.3 4.3 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding Baculo_PEP_C PF04513.12 EDN04143.1 - 7.2 6.7 16.6 2.1 8.4 1.5 3.6 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoO PF09769.9 EDN04143.1 - 7.9 6.5 12.2 7 6.6 0.1 3.8 2 1 2 5 5 5 0 Apolipoprotein O Fez1 PF06818.15 EDN04143.1 - 9.2 6.7 55.0 1.8 8.9 11.5 3.4 1 1 3 4 4 4 0 Fez1 Spc7 PF08317.11 EDN04143.1 - 9.5 5.0 55.9 8.4 5.2 22.5 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Pox_A_type_inc PF04508.12 EDN04143.1 - 9.9 6.2 13.3 0.68 9.9 2.6 3.7 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat NFACT-R_1 PF05670.13 EDN04144.1 - 3e-22 79.3 0.0 5.3e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain DAO PF01266.24 EDN04146.1 - 4.2e-48 164.7 0.1 1e-47 163.5 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.5 EDN04146.1 - 1.1e-42 144.8 0.0 1.9e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EDN04146.1 - 0.00027 20.1 2.3 0.0036 16.4 2.3 2.2 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EDN04146.1 - 0.016 14.6 0.1 0.069 12.5 0.2 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EDN04146.1 - 0.085 12.7 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EDN04146.1 - 0.085 13.1 0.2 0.41 10.9 0.2 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EDN04147.1 - 5.7e-14 52.1 0.0 1.7e-13 50.6 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EDN04147.1 - 0.032 13.3 0.0 0.11 11.5 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase DUF3335 PF11814.8 EDN04147.1 - 0.2 11.1 0.1 1.8 8.0 0.0 2.0 2 0 0 2 2 2 0 Peptidase_C39 like family Ecl1 PF12855.7 EDN04149.1 - 1.3e-13 52.5 11.0 1.5e-13 52.3 11.0 1.0 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-FLZ PF04570.14 EDN04149.1 - 0.8 9.2 3.7 18 4.9 3.7 2.2 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 TRI5 PF06330.11 EDN04150.1 - 0.14 11.0 0.5 0.17 10.7 0.5 1.0 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) DUF4603 PF15376.6 EDN04150.1 - 0.33 8.3 5.4 0.37 8.1 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Shugoshin_N PF07558.11 EDN04151.1 - 6.5e-18 64.3 4.6 1.8e-17 62.9 4.6 1.8 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EDN04151.1 - 3e-09 36.5 6.0 3e-09 36.5 6.0 2.9 2 0 0 2 2 2 1 Shugoshin C terminus ZapB PF06005.12 EDN04151.1 - 0.12 12.8 2.0 0.27 11.7 2.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_1 PF00170.21 EDN04151.1 - 0.32 11.1 5.5 0.18 11.9 1.3 2.5 2 0 0 2 2 2 0 bZIP transcription factor PPI_Ypi1 PF07491.11 EDN04152.1 - 2.5e-23 81.6 3.9 7.4e-23 80.1 3.9 1.8 1 1 0 1 1 1 1 Protein phosphatase inhibitor AF-4 PF05110.13 EDN04152.1 - 0.0082 14.3 1.8 0.0092 14.1 1.8 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Ribosomal_S21e PF01249.18 EDN04152.1 - 0.098 12.8 0.6 19 5.5 0.0 2.9 2 1 1 3 3 3 0 Ribosomal protein S21e IMUP PF15761.5 EDN04152.1 - 0.55 11.0 8.4 1.7 9.4 8.4 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein CRM1_repeat_3 PF18787.1 EDN04153.1 - 1e-31 108.8 1.3 1.1e-30 105.4 0.9 2.4 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 DUF3385 PF11865.8 EDN04153.1 - 0.0034 17.3 0.0 0.019 14.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 EDN04153.1 - 0.023 13.3 0.0 0.085 11.4 0.0 1.7 1 1 1 2 2 2 0 Adaptin N terminal region OCIA PF07051.11 EDN04153.1 - 0.14 12.2 0.3 18 5.5 0.0 2.6 2 1 0 2 2 2 0 Ovarian carcinoma immunoreactive antigen (OCIA) Mac_assoc PF16628.5 EDN04154.1 - 4e-64 216.2 9.3 4e-64 216.2 9.3 2.8 2 1 0 2 2 2 1 Unstructured region on maltose acetyltransferase Mac PF12464.8 EDN04154.1 - 2.7e-14 53.2 0.5 5.6e-14 52.1 0.5 1.5 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 EDN04154.1 - 1e-12 47.2 5.2 2.9e-07 29.9 0.2 3.5 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Zn_clus PF00172.18 EDN04154.1 - 2.2e-09 37.3 8.2 3.9e-09 36.5 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexapep_2 PF14602.6 EDN04154.1 - 3.9e-07 29.7 5.5 8.7e-06 25.4 0.1 3.0 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase ALAD PF00490.21 EDN04155.1 - 5.3e-114 380.7 0.0 6.6e-114 380.3 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DRE2_N PF16803.5 EDN04156.1 - 9.6e-42 142.3 0.0 1.3e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus CIAPIN1 PF05093.13 EDN04156.1 - 7.4e-41 138.7 4.7 1.4e-40 137.8 4.7 1.5 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis FXR_C1 PF16096.5 EDN04158.1 - 0.034 14.3 1.0 0.11 12.7 1.0 1.9 1 1 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 Nucleoporin_C PF03177.14 EDN04159.1 - 1.2e-188 628.6 1.1 1.4e-188 628.4 1.1 1.0 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal zf-UBP_var PF17807.1 EDN04160.1 - 1.8e-09 37.2 0.1 1.8e-09 37.2 0.1 2.1 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EDN04160.1 - 2.6e-08 34.1 20.2 1.2e-05 25.6 7.5 2.8 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein DUF2652 PF10851.8 EDN04160.1 - 0.013 15.6 0.8 0.039 14.1 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2652) DUF3795 PF12675.7 EDN04160.1 - 8.7 6.8 18.7 70 3.9 17.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3795) Rep_fac-A_C PF08646.10 EDN04161.1 - 4.9e-52 175.6 11.4 9.2e-50 168.2 6.4 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EDN04161.1 - 8.5e-37 125.0 0.4 4.1e-36 122.8 0.2 2.1 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 EDN04161.1 - 1.2e-22 79.9 0.0 3e-22 78.6 0.0 1.7 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EDN04161.1 - 4.5e-14 52.2 0.2 1.2e-09 38.0 0.0 3.9 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EDN04161.1 - 0.0032 17.2 1.8 0.15 11.7 1.8 2.9 2 1 0 2 2 2 1 Cell division control protein 24, OB domain 3 zf_UBZ PF18439.1 EDN04161.1 - 0.075 12.6 1.3 0.37 10.4 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF4539 PF15072.6 EDN04161.1 - 0.1 12.7 0.0 0.88 9.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) ADH_zinc_N PF00107.26 EDN04162.1 - 1.5e-22 80.0 0.0 2.7e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDN04162.1 - 4.9e-20 72.9 0.0 7.4e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN04162.1 - 2.8e-08 33.6 0.0 8.4e-08 32.1 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DapB_N PF01113.20 EDN04162.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DEAD PF00270.29 EDN04163.1 - 2.9e-47 160.7 0.0 6.3e-47 159.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN04163.1 - 2.7e-31 108.2 0.0 1.1e-28 99.8 0.0 2.8 2 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN04163.1 - 7.5e-08 32.6 0.0 1.4e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDN04163.1 - 0.00057 19.2 0.0 0.00098 18.4 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SNF2_N PF00176.23 EDN04163.1 - 0.01 14.6 0.0 0.014 14.1 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain CMS1 PF14617.6 EDN04163.1 - 0.056 12.8 0.0 0.16 11.3 0.0 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UTP25 PF06862.12 EDN04163.1 - 0.074 11.8 0.3 2.3 6.9 0.1 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Rft-1 PF04506.13 EDN04164.1 - 1.8e-135 452.6 5.1 2.2e-135 452.3 5.1 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 EDN04164.1 - 0.11 11.7 10.8 0.28 10.3 8.0 2.6 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 EDN04164.1 - 5.3 6.3 16.5 0.069 12.5 5.6 2.7 2 1 1 3 3 3 0 Polysaccharide biosynthesis protein OST3_OST6 PF04756.13 EDN04165.1 - 4.7e-102 341.3 0.0 6.2e-102 340.9 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 EDN04165.1 - 0.034 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin CD20 PF04103.15 EDN04165.1 - 5.6 7.0 8.8 2.6 8.1 0.0 3.0 3 0 0 3 3 3 0 CD20-like family ATG16 PF08614.11 EDN04166.1 - 0.0017 18.6 15.7 0.0017 18.6 15.7 4.1 1 1 2 4 4 4 1 Autophagy protein 16 (ATG16) COMP PF11598.8 EDN04166.1 - 4 8.0 8.6 3.9 8.0 1.6 3.6 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein COG2 PF06148.11 EDN04166.1 - 8.9 6.4 22.3 2 8.5 0.1 3.9 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 FtsJ PF01728.19 EDN04167.1 - 2.4e-34 119.0 0.0 3.2e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase ATG7_N PF16420.5 EDN04168.1 - 8.6e-112 373.6 0.0 1.1e-111 373.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EDN04168.1 - 9e-44 149.7 0.0 1.3e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EDN04168.1 - 0.0055 16.8 0.0 0.037 14.1 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EDN04168.1 - 0.092 12.1 0.0 0.34 10.2 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain His_biosynth PF00977.21 EDN04170.1 - 2.8e-47 161.1 0.2 8e-47 159.6 0.2 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EDN04170.1 - 5e-24 85.1 0.0 7.7e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EDN04170.1 - 6.5e-11 42.4 0.0 3.3e-10 40.1 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EDN04170.1 - 5.4e-09 35.9 0.0 1e-08 35.0 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EDN04170.1 - 0.026 14.3 0.4 0.12 12.1 0.4 2.0 1 1 0 1 1 1 0 Peptidase C26 DWNN PF08783.11 EDN04171.1 - 4.3e-34 116.6 0.1 8.7e-34 115.6 0.1 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EDN04171.1 - 5.3e-08 32.5 5.0 5.3e-08 32.5 5.0 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EDN04171.1 - 0.0029 17.4 8.9 0.0069 16.2 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 EDN04171.1 - 0.0034 17.4 0.7 0.0034 17.4 0.7 1.8 2 0 0 2 2 2 1 Zinc knuckle DUF966 PF06136.13 EDN04171.1 - 0.0036 17.1 5.7 0.0068 16.2 5.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF966) zf-RING_2 PF13639.6 EDN04171.1 - 0.028 14.7 6.9 0.076 13.4 6.9 1.8 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.6 EDN04171.1 - 0.34 10.7 6.3 0.95 9.3 6.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 EDN04171.1 - 0.9 9.5 8.9 2.3 8.2 8.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EDN04171.1 - 0.9 9.4 5.4 2 8.3 5.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 EDN04171.1 - 1.2 9.4 9.2 3.2 8.0 9.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FYVE_2 PF02318.16 EDN04171.1 - 9 6.5 8.9 1.1 9.5 3.5 2.2 2 1 0 2 2 2 0 FYVE-type zinc finger zf-RING_5 PF14634.6 EDN04171.1 - 9.4 6.3 14.4 0.85 9.6 8.3 2.3 2 1 0 2 2 2 0 zinc-RING finger domain ATG22 PF11700.8 EDN04172.1 - 6.5e-153 509.8 1.7 7.4e-153 509.6 1.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_2 PF13347.6 EDN04172.1 - 2.4e-05 23.1 5.3 2.4e-05 23.1 5.3 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein SWIRM PF04433.17 EDN04173.1 - 1.1e-11 44.9 0.0 2.5e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain CDC50 PF03381.15 EDN04174.1 - 4.9e-64 216.5 0.0 6.4e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family p450 PF00067.22 EDN04175.1 - 4.6e-21 75.1 0.0 6.5e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SPT16 PF08644.11 EDN04176.1 - 2.4e-58 196.6 0.0 9.1e-58 194.7 0.0 2.1 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EDN04176.1 - 4.3e-41 140.4 2.6 2e-22 79.7 0.0 3.3 2 1 1 3 3 3 2 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EDN04176.1 - 3.4e-27 95.5 0.0 6.2e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EDN04176.1 - 1.9e-15 57.1 0.6 6.3e-15 55.4 0.0 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Mito_carr PF00153.27 EDN04177.1 - 4.7e-18 64.9 1.4 2.4e-11 43.4 0.1 2.8 3 0 0 3 3 3 2 Mitochondrial carrier protein Sugar_tr PF00083.24 EDN04178.1 - 8.4e-102 341.3 15.5 9.9e-102 341.1 15.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN04178.1 - 5.3e-25 88.1 47.3 2e-23 82.9 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDN04178.1 - 3.2e-05 22.7 18.9 0.0013 17.4 5.6 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EDN04178.1 - 0.0035 16.3 6.4 0.29 9.9 0.4 2.2 1 1 1 2 2 2 2 MFS_1 like family INSIG PF07281.12 EDN04178.1 - 0.0056 16.3 2.6 0.0056 16.3 2.6 1.8 2 0 0 2 2 2 1 Insulin-induced protein (INSIG) Mito_fiss_reg PF05308.11 EDN04180.1 - 0.045 13.8 4.2 0.063 13.4 4.2 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Retrotran_gag_3 PF14244.6 EDN04180.1 - 0.054 13.3 0.1 0.094 12.5 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type CAP_N PF01213.19 EDN04180.1 - 0.065 12.7 5.5 0.088 12.3 5.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal P3A PF08727.11 EDN04181.1 - 0.055 12.8 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 Poliovirus 3A protein like PMT PF02366.18 EDN04183.1 - 2.9e-68 230.1 17.4 4.2e-35 121.5 0.1 3.3 2 2 2 4 4 4 2 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDN04183.1 - 2.6e-62 209.9 17.6 2.6e-62 209.9 17.6 2.5 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDN04183.1 - 3e-35 121.8 0.8 4.6e-35 121.2 0.8 1.1 1 0 0 1 1 1 1 MIR domain Ras PF00071.22 EDN04184.1 - 9e-46 155.4 0.0 3e-35 121.2 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EDN04184.1 - 2.8e-28 98.6 0.0 8.4e-18 64.7 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN04184.1 - 4.6e-07 29.5 0.0 1.4e-06 27.9 0.0 1.8 2 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN04184.1 - 4.3e-06 26.4 0.0 7.1e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN04184.1 - 0.00085 18.7 0.0 0.0044 16.4 0.0 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDN04184.1 - 0.00087 19.4 0.0 1.7 8.8 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDN04184.1 - 0.04 13.8 0.0 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EDN04184.1 - 0.15 12.3 0.1 1.4 9.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain DUF3100 PF11299.8 EDN04186.1 - 0.011 15.2 3.0 0.013 14.9 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3100) CYYR1 PF10873.8 EDN04186.1 - 0.19 12.2 0.4 0.23 11.9 0.4 1.1 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Aldo_ket_red PF00248.21 EDN04188.1 - 0.0049 16.1 0.0 0.26 10.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Corona_5a PF06336.11 EDN04188.1 - 0.049 13.6 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Coronavirus 5a protein UPF0061 PF02696.14 EDN04189.1 - 1.1e-111 373.9 0.0 1.5e-111 373.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family zf-CCHC PF00098.23 EDN04191.1 - 4.1e-40 134.1 50.8 2.4e-09 36.8 2.0 6.6 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_4 PF14392.6 EDN04191.1 - 4.1e-09 36.0 36.5 0.0059 16.3 0.7 6.1 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_5 PF14787.6 EDN04191.1 - 5.5e-06 26.0 27.6 0.022 14.5 0.6 5.5 4 1 1 5 5 5 4 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 EDN04191.1 - 0.0041 17.1 40.4 0.15 12.0 0.5 5.5 4 1 2 6 6 6 5 Zinc knuckle zf-CCHC_6 PF15288.6 EDN04191.1 - 0.036 13.9 0.8 0.036 13.9 0.8 5.7 5 1 1 6 6 6 0 Zinc knuckle F-box PF00646.33 EDN04192.1 - 1.5e-07 31.1 0.1 3.5e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN04192.1 - 4.3e-06 26.5 0.1 9.3e-06 25.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like Pex16 PF08610.10 EDN04193.1 - 2.4e-121 404.9 0.4 4.2e-121 404.1 0.4 1.4 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) SAE2 PF08573.10 EDN04193.1 - 5.9e-33 114.3 0.0 5.9e-33 114.3 0.0 3.2 5 0 0 5 5 5 1 DNA repair protein endonuclease SAE2/CtIP C-terminus YabA PF06156.13 EDN04193.1 - 0.18 12.5 2.7 0.88 10.2 2.7 2.2 1 1 0 1 1 1 0 Initiation control protein YabA Sigma54_AID PF00309.20 EDN04193.1 - 4.4 7.2 6.4 18 5.3 1.1 2.7 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) RNase_HII PF01351.18 EDN04194.1 - 2.9e-48 164.4 0.0 5.5e-48 163.4 0.0 1.4 1 1 0 1 1 1 1 Ribonuclease HII CENP-C_C PF11699.8 EDN04195.1 - 4.9e-36 122.8 1.1 9.9e-36 121.8 1.1 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 EDN04195.1 - 1.7e-26 93.5 8.9 1.7e-26 93.5 8.9 4.1 3 2 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 EDN04195.1 - 1.1e-06 28.2 0.0 2.8e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EDN04195.1 - 0.0038 16.8 0.1 0.0062 16.1 0.1 1.3 1 0 0 1 1 1 1 Cupin THEG4 PF15834.5 EDN04195.1 - 0.07 13.1 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 Testis highly expressed protein 4 Myb_DNA-binding PF00249.31 EDN04196.1 - 6.4e-14 51.9 4.0 2.5e-11 43.6 0.1 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN04196.1 - 2.3e-07 30.9 3.7 7.9e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Methyltransf_11 PF08241.12 EDN04197.1 - 1.3e-11 44.9 0.0 2.4e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04197.1 - 1.5e-09 38.4 0.0 2.8e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN04197.1 - 2.7e-08 33.8 0.0 5.4e-08 32.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN04197.1 - 7.9e-06 26.5 0.0 1.5e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ACT_4 PF13291.6 EDN04197.1 - 0.012 16.1 0.0 0.021 15.4 0.0 1.3 1 0 0 1 1 1 0 ACT domain Methyltransf_31 PF13847.6 EDN04197.1 - 0.064 13.1 0.0 0.15 11.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain RVT_2 PF07727.14 EDN04198.1 - 1.5e-43 149.2 0.0 2.3e-43 148.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN04198.1 - 2.5e-11 43.8 0.1 7.9e-11 42.2 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN04198.1 - 0.029 14.1 3.0 0.056 13.2 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN04198.1 - 0.032 14.1 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN04198.1 - 0.088 12.6 0.1 0.28 11.0 0.1 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_2 PF14223.6 EDN04198.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type MARVEL PF01284.23 EDN04201.1 - 5.5e-26 91.3 15.5 6.7e-26 91.1 15.5 1.0 1 0 0 1 1 1 1 Membrane-associating domain EF-hand_4 PF12763.7 EDN04202.1 - 1.1e-38 131.3 0.0 2.9e-15 56.1 0.0 3.9 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EDN04202.1 - 5.9e-09 36.3 0.0 3.5e-05 24.2 0.0 4.1 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EDN04202.1 - 7.1e-09 34.6 0.1 0.0013 18.1 0.0 5.5 7 0 0 7 7 6 2 EF hand UBA PF00627.31 EDN04202.1 - 2.3e-08 33.7 0.1 6.3e-08 32.4 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_8 PF13833.6 EDN04202.1 - 5.6e-06 26.1 0.0 0.02 14.8 0.0 3.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EDN04202.1 - 2.5e-05 23.8 0.2 1.5 8.9 0.0 5.5 5 0 0 5 5 5 1 EF-hand domain ERM PF00769.19 EDN04202.1 - 0.0083 16.0 15.0 0.02 14.8 15.0 1.7 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Spc7 PF08317.11 EDN04202.1 - 0.01 14.7 27.3 0.16 10.8 15.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 EDN04202.1 - 0.021 14.2 26.4 0.27 10.5 13.2 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EDN04202.1 - 0.13 12.4 32.3 0.27 11.3 18.3 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EDN04202.1 - 0.2 11.7 22.1 1.2 9.1 6.3 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 EDN04202.1 - 0.21 10.4 19.0 0.43 9.4 19.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF812) APG6_N PF17675.1 EDN04202.1 - 0.4 11.2 29.0 3.6 8.1 17.1 2.9 1 1 2 3 3 3 0 Apg6 coiled-coil region Filament PF00038.21 EDN04202.1 - 0.71 9.4 25.6 1.2 8.7 0.4 3.0 1 1 2 3 3 3 0 Intermediate filament protein DUF3450 PF11932.8 EDN04202.1 - 0.86 8.9 26.1 0.013 14.8 15.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) PRKG1_interact PF15898.5 EDN04202.1 - 0.87 10.5 21.2 0.12 13.3 10.2 3.3 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain Phage_GP20 PF06810.11 EDN04202.1 - 1 9.2 21.9 0.13 12.0 1.1 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 MbeD_MobD PF04899.12 EDN04202.1 - 1.4 9.1 19.2 0.62 10.2 6.2 3.7 1 1 2 3 3 3 0 MbeD/MobD like DUF2730 PF10805.8 EDN04202.1 - 1.7 8.8 11.0 13 5.9 0.3 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF2730) Cep57_MT_bd PF06657.13 EDN04202.1 - 2.3 8.7 9.7 0.073 13.5 1.7 2.7 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.6 EDN04202.1 - 2.9 7.1 28.9 19 4.5 20.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 EDN04202.1 - 4.9 7.4 21.2 1.2 9.4 1.6 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Tropomyosin PF00261.20 EDN04202.1 - 5.9 6.2 22.8 0.21 10.9 5.3 2.3 1 1 0 2 2 2 0 Tropomyosin Tubulin PF00091.25 EDN04203.1 - 4.2e-51 174.0 0.0 7e-51 173.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDN04203.1 - 1.4e-50 170.7 0.1 2.5e-50 169.8 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EDN04203.1 - 0.0022 17.7 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Med9 PF07544.13 EDN04204.1 - 0.08 13.0 0.8 0.12 12.5 0.1 1.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Viral_env_E26 PF11050.8 EDN04204.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Virus envelope protein E26 Pga1 PF10333.9 EDN04205.1 - 0.0011 18.8 0.8 0.0017 18.3 0.0 1.8 2 0 0 2 2 2 1 GPI-Mannosyltransferase II co-activator Brix PF04427.18 EDN04207.1 - 1.1e-29 103.9 0.0 1.4e-29 103.6 0.0 1.1 1 0 0 1 1 1 1 Brix domain WW PF00397.26 EDN04208.1 - 1.3e-07 31.6 1.6 3.6e-07 30.2 1.6 1.8 1 0 0 1 1 1 1 WW domain TMEMspv1-c74-12 PF11044.8 EDN04208.1 - 0.13 12.2 1.2 0.21 11.6 1.2 1.3 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein F-box-like PF12937.7 EDN04209.1 - 0.014 15.3 0.4 0.039 13.9 0.4 1.8 1 0 0 1 1 1 0 F-box-like DUF4396 PF14342.6 EDN04210.1 - 9.2e-27 94.1 3.7 1.1e-26 93.8 3.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) RRM_5 PF13893.6 EDN04210.1 - 0.11 12.1 0.6 0.16 11.6 0.1 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF829 PF05705.14 EDN04214.1 - 3.3e-42 145.1 0.0 4.2e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) UFD1 PF03152.14 EDN04215.1 - 2.8e-69 232.0 0.0 3.5e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 EDN04215.1 - 0.17 11.7 0.0 5.9 6.7 0.0 2.3 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), domain 2 GYF PF02213.16 EDN04216.1 - 3.7e-12 45.7 3.6 9.9e-12 44.3 3.6 1.7 1 0 0 1 1 1 1 GYF domain PcfJ PF14284.6 EDN04216.1 - 0.027 14.4 0.2 0.051 13.5 0.2 1.4 1 0 0 1 1 1 0 PcfJ-like protein TIP49 PF06068.13 EDN04217.1 - 3.5e-154 513.2 2.8 4.6e-154 512.8 2.8 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDN04217.1 - 1.8e-20 72.8 0.2 6.3e-20 71.1 0.2 2.0 1 0 0 1 1 1 1 TIP49 AAA-lid domain RuvB_N PF05496.12 EDN04217.1 - 3.8e-08 33.3 0.5 2.9e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 EDN04217.1 - 5.6e-08 33.3 0.1 5e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EDN04217.1 - 9.6e-07 28.4 0.9 1.7e-06 27.6 0.9 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EDN04217.1 - 3.6e-06 27.5 0.0 1e-05 26.0 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EDN04217.1 - 0.0041 16.5 1.0 0.05 13.0 0.4 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDN04217.1 - 0.0056 16.7 0.4 0.77 9.8 0.0 3.2 3 1 1 4 4 4 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDN04217.1 - 0.0076 16.0 0.0 3 7.5 0.1 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 EDN04217.1 - 0.022 14.4 0.1 0.041 13.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDN04217.1 - 0.023 15.0 1.3 0.27 11.5 1.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN04217.1 - 0.065 13.4 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDN04217.1 - 0.085 12.6 0.2 0.16 11.7 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDN04217.1 - 0.11 12.0 0.2 0.45 10.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region Hydin_ADK PF17213.3 EDN04217.1 - 0.12 12.7 0.6 0.25 11.6 0.3 1.7 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain Parvo_NS1 PF01057.17 EDN04217.1 - 0.15 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Baculo_PEP_C PF04513.12 EDN04218.1 - 6.4e-07 29.5 31.0 0.028 14.5 5.1 4.4 3 1 1 4 4 4 3 Baculovirus polyhedron envelope protein, PEP, C terminus CK2S PF15011.6 EDN04218.1 - 0.0089 15.9 1.4 0.0089 15.9 1.4 5.2 2 2 2 5 5 5 1 Casein Kinase 2 substrate TMF_TATA_bd PF12325.8 EDN04218.1 - 0.015 15.5 1.0 0.015 15.5 1.0 5.9 2 2 3 6 6 6 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 EDN04218.1 - 0.016 15.2 39.3 0.3 11.1 3.8 6.1 3 2 3 6 6 6 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 EDN04218.1 - 0.017 15.2 0.2 0.017 15.2 0.2 5.5 3 1 3 6 6 6 0 TPR/MLP1/MLP2-like protein TPR_5 PF12688.7 EDN04218.1 - 0.027 14.7 2.4 0.041 14.1 0.4 2.3 2 0 0 2 2 2 0 Tetratrico peptide repeat DUF948 PF06103.11 EDN04218.1 - 0.33 11.2 15.4 2.6 8.4 1.5 5.2 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF1825 PF08855.10 EDN04218.1 - 1.3 8.9 13.0 1.2 9.0 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1825) Fez1 PF06818.15 EDN04218.1 - 2.7 8.4 48.1 0.49 10.8 15.3 4.1 2 2 1 3 3 3 0 Fez1 Bcr-Abl_Oligo PF09036.10 EDN04218.1 - 4.1 7.5 11.1 1 9.4 0.1 4.3 4 1 0 4 4 4 0 Bcr-Abl oncoprotein oligomerisation domain Exo_endo_phos_2 PF14529.6 EDN04224.1 - 1.9e-06 27.7 0.0 3.5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase OrsD PF12013.8 EDN04227.1 - 4.4e-37 127.0 4.9 4.4e-37 127.0 4.9 2.3 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EDN04230.1 - 5.9e-19 68.6 0.0 1.4e-18 67.4 0.0 1.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EDN04235.1 - 1.4e-05 25.5 0.2 1.4e-05 25.5 0.2 2.5 3 1 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D Retrotran_gag_3 PF14244.6 EDN04238.1 - 0.025 14.4 0.1 0.057 13.2 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN04238.1 - 0.087 12.5 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Helicase_C PF00271.31 EDN04239.1 - 8.4e-14 51.9 0.1 2.1e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Acyl-CoA_dh_N PF02771.16 EDN04240.1 - 8.4e-28 97.3 0.1 2.3e-27 95.9 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EDN04240.1 - 3.7e-25 88.9 0.1 5.9e-25 88.2 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDN04240.1 - 1.6e-15 57.1 0.0 3.1e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EDN04240.1 - 6.5e-06 26.5 0.1 1.2e-05 25.5 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SEF14_adhesin PF06443.11 EDN04241.1 - 0.00016 21.6 1.7 0.0002 21.3 1.7 1.1 1 0 0 1 1 1 1 SEF14-like adhesin TraT PF05818.12 EDN04241.1 - 0.15 11.8 1.5 0.17 11.6 1.5 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein RVT_2 PF07727.14 EDN04242.1 - 1.6e-06 27.9 0.1 1.7e-06 27.8 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN04243.1 - 2.8e-12 47.0 0.0 6e-12 46.0 0.0 1.5 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN04243.1 - 0.095 12.5 0.1 0.27 11.0 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like NAD_binding_6 PF08030.12 EDN04244.1 - 0.016 15.4 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDN04244.1 - 0.49 10.5 14.5 0.024 14.8 3.7 3.3 2 1 2 4 4 4 0 Ferric reductase like transmembrane component HTH_8 PF02954.19 EDN04245.1 - 0.021 14.6 0.1 0.39 10.6 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family CK_II_beta PF01214.18 EDN04245.1 - 0.035 13.9 0.1 0.068 13.0 0.1 1.5 1 0 0 1 1 1 0 Casein kinase II regulatory subunit DDE_1 PF03184.19 EDN04245.1 - 0.051 13.2 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease YabA PF06156.13 EDN04245.1 - 0.63 10.7 5.0 2 9.1 5.0 1.9 1 0 0 1 1 1 0 Initiation control protein YabA Vps39_1 PF10366.9 EDN04246.1 - 0.057 13.7 0.4 0.39 11.0 0.1 2.4 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Cohesin_HEAT PF12765.7 EDN04248.1 - 0.059 13.7 0.5 0.74 10.2 0.2 2.8 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Methyltransf_23 PF13489.6 EDN04249.1 - 2e-10 40.7 0.0 4.7e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN04249.1 - 0.00022 21.1 0.1 0.031 14.1 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04249.1 - 0.0015 19.2 0.0 0.0083 16.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Astro_capsid_p PF12226.8 EDN04249.1 - 0.17 11.0 4.7 0.25 10.5 4.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein dsDNA_bind PF01984.20 EDN04250.1 - 4.2e-40 136.5 14.0 4.9e-40 136.3 14.0 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain cwf18 PF08315.12 EDN04250.1 - 0.082 13.6 5.2 0.11 13.2 5.2 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor NIBRIN_BRCT_II PF16508.5 EDN04251.1 - 3.8e-17 62.7 0.0 2.7e-16 60.0 0.0 2.2 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 EDN04251.1 - 0.00017 21.8 0.5 0.00046 20.5 0.5 1.8 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.5 EDN04251.1 - 0.055 13.4 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain IMS PF00817.20 EDN04252.1 - 1.9e-41 141.5 0.1 3.2e-41 140.8 0.1 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.8 EDN04252.1 - 3.5e-06 27.0 0.0 1.2e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 IMS family HHH motif BAF PF02961.14 EDN04252.1 - 0.056 13.9 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 Barrier to autointegration factor DDE_1 PF03184.19 EDN04253.1 - 1.8e-30 105.9 0.0 1.1e-29 103.3 0.0 2.2 3 0 0 3 3 3 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN04253.1 - 0.0021 17.8 0.0 0.0055 16.5 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Blo-t-5 PF11642.8 EDN04254.1 - 1.3 9.0 3.4 16 5.5 0.1 2.2 2 0 0 2 2 2 0 Mite allergen Blo t 5 DnaJ-X PF14308.6 EDN04255.1 - 7.3e-60 202.0 3.7 7.3e-60 202.0 3.7 3.3 3 2 0 4 4 4 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDN04255.1 - 2.6e-26 91.5 0.3 7.2e-26 90.1 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain HisG_C PF08029.11 EDN04255.1 - 0.00037 20.6 0.1 0.00078 19.5 0.1 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain Dicty_REP PF05086.12 EDN04255.1 - 1.1 7.2 5.4 1.8 6.4 5.4 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2924 PF11149.8 EDN04255.1 - 3.9 7.9 14.1 2.5 8.5 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2924) SQS_PSY PF00494.19 EDN04256.1 - 2.4e-39 135.4 0.0 4.2e-39 134.6 0.0 1.4 2 0 0 2 2 2 1 Squalene/phytoene synthase Fungal_trans PF04082.18 EDN04257.1 - 0.00016 20.8 0.0 0.00023 20.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain UPF0254 PF06787.11 EDN04258.1 - 0.18 11.6 0.0 0.23 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) ECH_1 PF00378.20 EDN04259.1 - 0.00042 19.7 0.0 0.0006 19.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase RVT_2 PF07727.14 EDN04260.1 - 1.1e-43 149.7 0.0 1.5e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mannosyl_trans PF05007.13 EDN04262.1 - 1.2e-76 258.1 15.2 1.6e-76 257.7 15.2 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EDN04262.1 - 2.3e-12 46.7 3.7 2.3e-12 46.7 3.7 2.1 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EDN04262.1 - 0.00062 19.6 20.9 0.00062 19.6 20.9 3.1 1 1 0 2 2 2 1 Glycosyltransferase family 87 CBP_BcsF PF11120.8 EDN04262.1 - 0.071 13.2 0.2 1.5 9.0 0.1 2.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF Translin PF01997.16 EDN04263.1 - 5.6e-70 235.5 0.0 6.9e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Translin family RPEL PF02755.15 EDN04264.1 - 5.1e-28 95.9 15.5 1.2e-09 37.5 1.7 3.5 3 0 0 3 3 3 3 RPEL repeat Rotamase_3 PF13616.6 EDN04264.1 - 0.0029 18.1 0.5 0.011 16.2 0.1 1.8 1 1 1 2 2 2 1 PPIC-type PPIASE domain DUF2737 PF10930.8 EDN04264.1 - 0.02 14.4 0.1 3.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2737) THOC7 PF05615.13 EDN04264.1 - 0.051 13.8 3.2 0.34 11.2 0.9 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 CCT_2 PF09425.10 EDN04264.1 - 0.14 12.1 1.8 14 5.7 0.0 2.5 2 0 0 2 2 2 0 Divergent CCT motif Zip PF02535.22 EDN04265.1 - 4.8e-68 229.8 7.2 5.7e-68 229.6 7.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2157 PF09925.9 EDN04265.1 - 1 9.1 5.6 0.83 9.4 0.2 3.0 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) Tom37 PF10568.9 EDN04266.1 - 1.2e-39 135.5 0.0 2.3e-39 134.5 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EDN04266.1 - 8.5e-10 38.3 0.0 3.8e-09 36.2 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EDN04266.1 - 0.0048 17.6 0.0 0.013 16.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain TMEM51 PF15345.6 EDN04266.1 - 0.12 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 DDE_Tnp_1_7 PF13843.6 EDN04267.1 - 1e-51 176.3 1.5 9e-26 91.0 0.1 2.1 2 0 0 2 2 2 2 Transposase IS4 PBP1_TM PF14812.6 EDN04268.1 - 0.41 11.1 8.7 0.13 12.7 4.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NAPRTase PF04095.16 EDN04269.1 - 2.3e-52 178.0 0.2 2.7e-27 95.9 0.2 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EDN04269.1 - 5e-22 78.6 0.5 1e-15 58.2 0.0 2.3 1 1 1 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Syntaxin PF00804.25 EDN04270.1 - 1.1e-19 70.9 8.3 1.1e-19 70.9 8.3 2.0 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 EDN04270.1 - 2.1e-08 34.0 1.2 6e-08 32.6 0.2 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EDN04270.1 - 4.5e-05 23.8 6.7 8.4e-05 22.9 0.2 2.6 2 1 0 2 2 2 1 Syntaxin-like protein Gp-FAR-1 PF05823.12 EDN04270.1 - 0.0023 18.3 1.8 0.0024 18.2 0.1 1.8 2 0 0 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) zf-CpG_bind_C PF12269.8 EDN04270.1 - 0.018 14.8 6.1 0.08 12.7 0.2 2.2 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain COG5 PF10392.9 EDN04270.1 - 0.052 13.7 1.4 2.9 8.1 0.1 2.5 2 1 0 2 2 2 0 Golgi transport complex subunit 5 PTA_PTB PF01515.19 EDN04270.1 - 0.12 11.7 1.5 0.2 10.9 1.5 1.3 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase MCPsignal PF00015.21 EDN04270.1 - 0.79 9.5 6.9 0.63 9.8 3.3 2.4 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Spectrin PF00435.21 EDN04270.1 - 1.2 9.6 8.5 1.9 9.0 0.1 2.8 2 1 0 3 3 3 0 Spectrin repeat Occludin_ELL PF07303.13 EDN04270.1 - 2.2 9.1 4.4 6.6 7.5 0.2 3.2 2 1 0 3 3 3 0 Occludin homology domain BLOC1_2 PF10046.9 EDN04270.1 - 2.3 8.6 7.7 1.9 8.9 1.2 3.0 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HisKA_3 PF07730.13 EDN04270.1 - 2.3 8.8 7.5 3.5 8.2 0.1 3.8 4 2 0 4 4 4 0 Histidine kinase Fib_alpha PF08702.10 EDN04270.1 - 2.3 8.4 9.2 2.5 8.3 0.1 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 EDN04270.1 - 5.8 7.6 11.6 0.76 10.4 2.3 3.6 2 1 2 4 4 4 0 SlyX Baculo_F PF12259.8 EDN04270.1 - 6.1 5.2 6.3 10 4.5 0.1 2.1 1 1 1 2 2 2 0 Baculovirus F protein AMP-binding PF00501.28 EDN04271.1 - 5.7e-61 206.4 0.0 1.6e-60 204.9 0.0 1.6 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN04271.1 - 5.5e-10 40.1 0.0 1.2e-09 39.0 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LINES_C PF14695.6 EDN04271.1 - 0.13 11.7 0.4 0.52 9.8 0.0 2.1 2 0 0 2 2 2 0 Lines C-terminus IF4E PF01652.18 EDN04272.1 - 1e-53 181.4 0.8 1.3e-53 181.1 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Nexin_C PF08628.12 EDN04274.1 - 0.0038 17.8 0.2 0.0039 17.8 0.2 1.1 1 0 0 1 1 1 1 Sorting nexin C terminal DUF3699 PF12480.8 EDN04274.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3699) RVT_1 PF00078.27 EDN04275.1 - 1.9e-33 115.9 0.0 3.1e-33 115.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN04275.1 - 8.5e-12 45.5 0.0 2e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN04275.1 - 5e-11 42.5 0.0 1.5e-10 41.0 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Dsh_C PF12316.8 EDN04275.1 - 8.9 6.7 11.1 3.5 8.0 8.1 1.8 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal RVT_2 PF07727.14 EDN04276.1 - 7.6e-32 110.9 0.0 4.8e-25 88.6 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN04276.1 - 1.5e-09 38.1 0.0 7e-09 35.9 0.0 2.2 1 1 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 EDN04276.1 - 0.00046 20.1 2.5 0.00091 19.2 2.5 1.4 1 0 0 1 1 1 1 Zinc knuckle gag_pre-integrs PF13976.6 EDN04276.1 - 0.002 17.9 0.0 0.0076 16.1 0.0 2.0 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN04276.1 - 0.011 15.4 0.0 0.028 14.1 0.0 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type U3_snoRNA_assoc PF08297.11 EDN04276.1 - 0.42 11.4 6.8 2.6 8.8 6.8 2.5 1 0 0 1 1 1 0 U3 snoRNA associated RTC4 PF14474.6 EDN04279.1 - 1.2e-26 93.3 0.0 1.6e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 RTC4-like domain APH PF01636.23 EDN04281.1 - 1.3e-09 38.4 0.3 7.8e-09 35.8 0.3 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EDN04281.1 - 0.086 12.1 0.0 0.22 10.8 0.0 1.8 1 1 0 1 1 1 0 Protein tyrosine kinase DUF3435 PF11917.8 EDN04283.1 - 2e-149 498.1 0.2 2.6e-149 497.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2_4 PF13894.6 EDN04283.1 - 7.9 7.6 6.4 27 5.9 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger Zn_clus PF00172.18 EDN04285.1 - 2.9e-08 33.7 8.7 7.2e-08 32.4 8.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase_fungal PF17667.1 EDN04287.1 - 2.1e-103 346.3 0.9 8.1e-84 281.7 0.0 2.1 1 1 1 2 2 2 2 Fungal protein kinase DUF1874 PF08960.10 EDN04287.1 - 0.088 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) RTC4 PF14474.6 EDN04288.1 - 6.5e-26 90.9 0.1 9.7e-26 90.3 0.1 1.3 1 0 0 1 1 1 1 RTC4-like domain Myb_DNA-bind_6 PF13921.6 EDN04288.1 - 0.0014 18.8 0.4 0.0044 17.2 0.4 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN04288.1 - 0.044 14.0 0.6 0.044 14.0 0.6 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain Pkinase PF00069.25 EDN04289.1 - 0.00017 21.0 0.0 0.0002 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN04289.1 - 0.00032 20.1 0.1 0.00048 19.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDN04289.1 - 0.059 13.0 0.4 4.9 6.7 0.1 2.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDN04289.1 - 0.14 12.1 0.2 0.21 11.5 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family HTH_Tnp_Tc5 PF03221.16 EDN04290.1 - 0.049 13.7 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain E1_UFD PF09358.10 EDN04290.1 - 0.052 14.3 0.2 0.06 14.1 0.2 1.1 1 0 0 1 1 1 0 Ubiquitin fold domain Pkinase_fungal PF17667.1 EDN04292.1 - 6e-69 232.8 0.0 7.6e-69 232.4 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN04292.1 - 5.4e-06 26.0 0.0 8.8e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EDN04292.1 - 0.025 14.2 0.0 0.055 13.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN04292.1 - 0.12 12.3 0.0 0.88 9.4 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_S5 PF00333.20 EDN04295.1 - 5.7e-27 93.5 1.7 9.3e-27 92.8 1.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDN04295.1 - 4.3e-24 83.8 0.0 7e-24 83.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Bac_rhodopsin PF01036.18 EDN04297.1 - 1.1e-39 136.3 18.3 1.4e-39 136.0 18.3 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein AWPM-19 PF05512.11 EDN04297.1 - 0.012 15.8 4.0 0.023 14.9 3.7 1.8 1 1 0 1 1 1 0 AWPM-19-like family 7TM_GPCR_Srz PF10325.9 EDN04297.1 - 0.31 10.3 9.4 0.99 8.7 1.5 2.4 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srz Phage_holin_3_6 PF07332.11 EDN04297.1 - 3.8 7.6 18.4 0.36 10.9 3.2 3.1 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4131 PF13567.6 EDN04297.1 - 5.7 6.6 13.7 0.5 10.0 0.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) PGG PF13962.6 EDN04297.1 - 9.1 6.1 12.0 0.17 11.7 1.7 2.9 2 2 0 2 2 2 0 Domain of unknown function tRNA-synt_1 PF00133.22 EDN04299.1 - 1.5e-145 485.9 0.0 2.5e-91 306.8 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) UPF0183 PF03676.14 EDN04299.1 - 3.3e-45 155.1 0.0 1.9e-36 126.2 0.0 2.6 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) Anticodon_1 PF08264.13 EDN04299.1 - 1.3e-20 73.9 0.6 2.6e-20 72.9 0.6 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDN04299.1 - 8e-16 57.8 0.0 8.1e-10 38.0 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDN04299.1 - 0.022 14.3 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDN04299.1 - 0.12 11.7 0.0 15 4.8 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Kinesin PF00225.23 EDN04300.1 - 5.5e-108 360.8 0.1 1.1e-107 359.8 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDN04300.1 - 8.3e-23 81.0 2.5 1.8e-22 79.9 0.0 2.8 3 0 0 3 3 3 1 Microtubule binding Microtub_bind PF13931.6 EDN04300.1 - 2.6e-07 31.1 0.2 2.6e-07 31.1 0.2 4.5 4 1 0 4 4 4 1 Kinesin-associated microtubule-binding DUF1825 PF08855.10 EDN04300.1 - 0.0057 16.6 0.4 0.0057 16.6 0.4 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1825) UPF0184 PF03670.13 EDN04300.1 - 0.25 11.8 0.1 0.25 11.8 0.1 3.3 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0184) DUF948 PF06103.11 EDN04300.1 - 1.8 8.9 23.1 2.8 8.3 0.1 6.1 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) CCDC84 PF14968.6 EDN04301.1 - 0.086 12.5 1.1 0.1 12.2 0.2 1.5 2 0 0 2 2 2 0 Coiled coil protein 84 zf-ANAPC11 PF12861.7 EDN04302.1 - 2.8e-46 155.5 8.9 3.6e-46 155.2 8.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EDN04302.1 - 3.7e-21 75.1 9.2 5.3e-21 74.7 9.2 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDN04302.1 - 2.5e-08 34.1 14.1 6.3e-07 29.6 14.1 2.5 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EDN04302.1 - 0.00015 21.7 4.5 0.00015 21.7 4.5 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDN04302.1 - 0.00061 19.6 11.7 0.0025 17.6 11.7 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN04302.1 - 0.0018 18.1 15.8 0.0034 17.2 12.4 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN04302.1 - 0.0048 16.7 11.3 0.0051 16.6 6.1 2.4 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EDN04302.1 - 0.011 15.5 10.7 0.44 10.4 7.5 2.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EDN04302.1 - 0.03 14.3 14.8 0.27 11.2 15.0 2.6 1 1 1 2 2 2 0 zinc-RING finger domain zf-HIT PF04438.16 EDN04302.1 - 0.062 13.2 1.3 0.062 13.2 1.3 2.4 2 0 0 2 2 2 0 HIT zinc finger FANCL_C PF11793.8 EDN04302.1 - 0.19 11.9 15.8 3.2 8.0 15.8 3.0 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EDN04302.1 - 0.21 11.3 12.2 0.51 10.0 10.1 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type RecR PF02132.15 EDN04302.1 - 0.24 11.0 5.5 7.8 6.2 0.1 3.1 3 0 0 3 3 3 0 RecR protein Pellino PF04710.14 EDN04302.1 - 0.41 9.2 3.0 0.17 10.5 0.4 1.6 1 1 0 1 1 1 0 Pellino zf-RING_11 PF17123.5 EDN04302.1 - 0.46 10.3 10.3 4 7.3 10.3 2.3 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 EDN04302.1 - 1.8 8.8 13.6 0.71 10.1 8.9 2.7 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING DZR PF12773.7 EDN04302.1 - 2.1 8.5 12.4 2.3 8.3 5.1 2.5 1 1 1 2 2 2 0 Double zinc ribbon PHD PF00628.29 EDN04302.1 - 2.1 8.3 12.0 9.6 6.2 12.0 2.1 1 1 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EDN04302.1 - 3.7 7.9 10.2 8.1 6.8 8.4 2.2 1 1 1 2 2 2 0 RING-like domain Rhodanese PF00581.20 EDN04303.1 - 2.9e-15 56.7 0.0 3.1e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain Ribosom_S12_S23 PF00164.25 EDN04303.1 - 0.0066 16.0 0.2 0.017 14.7 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S12/S23 PIN_4 PF13638.6 EDN04304.1 - 0.00071 19.9 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 PIN domain Cyt-b5 PF00173.28 EDN04305.1 - 1.9e-16 60.0 0.0 2.5e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FKBP_C PF00254.28 EDN04306.1 - 1.8e-31 108.3 0.0 2.3e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Abhydrolase_2 PF02230.16 EDN04309.1 - 7.2e-21 75.0 0.0 3.3e-15 56.5 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 EDN04309.1 - 0.0035 17.0 0.0 0.018 14.7 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EDN04309.1 - 0.0067 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EDN04309.1 - 0.038 13.2 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Acyl_transf_3 PF01757.22 EDN04310.1 - 3.8e-24 85.4 22.8 5.6e-24 84.8 22.8 1.3 1 0 0 1 1 1 1 Acyltransferase family Cyclin_N PF00134.23 EDN04311.1 - 2.3e-36 124.3 0.1 4.7e-36 123.3 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDN04311.1 - 6.3e-10 39.2 1.4 1.8e-09 37.7 1.4 1.8 1 1 0 1 1 1 1 Cyclin, C-terminal domain DDE_1 PF03184.19 EDN04312.1 - 8e-30 103.8 0.0 3.5e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN04312.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Metallophos PF00149.28 EDN04313.1 - 0.00032 21.2 0.1 0.00086 19.9 0.0 1.7 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase WD40 PF00400.32 EDN04314.1 - 5.1e-13 49.3 4.2 0.44 11.5 0.0 8.5 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04314.1 - 7.3e-10 39.0 0.0 0.02 15.2 0.0 5.8 3 3 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EDN04314.1 - 0.00059 19.5 0.0 0.016 14.8 0.0 3.1 3 1 0 3 3 3 1 PQQ-like domain F-box PF00646.33 EDN04315.1 - 0.0001 22.1 0.7 0.00029 20.6 0.4 1.9 2 0 0 2 2 2 1 F-box domain Jacalin PF01419.17 EDN04315.1 - 0.0014 18.5 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 Jacalin-like lectin domain F-box-like PF12937.7 EDN04315.1 - 0.0077 16.1 0.1 0.02 14.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like Rad4 PF03835.15 EDN04317.1 - 6.5e-07 29.1 0.7 1e-06 28.5 0.7 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Memo PF01875.17 EDN04318.1 - 1.7e-21 76.6 0.1 1.9e-21 76.4 0.1 1.1 1 0 0 1 1 1 1 Memo-like protein ANTH PF07651.16 EDN04321.1 - 5e-57 193.0 0.3 6.8e-57 192.6 0.3 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EDN04321.1 - 1.6e-10 41.1 0.3 7.7e-10 38.9 0.1 2.0 2 0 0 2 2 2 1 ENTH domain Gpr1_Fun34_YaaH PF01184.19 EDN04322.1 - 2.1e-88 295.3 19.2 2.6e-88 295.0 19.2 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 EDN04324.1 - 1.8e-15 57.1 7.0 2.2e-15 56.8 7.0 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Spore_YabQ PF09578.10 EDN04324.1 - 0.16 12.2 9.5 0.39 11.0 9.5 1.7 1 1 0 1 1 1 0 Spore cortex protein YabQ (Spore_YabQ) DUF3784 PF12650.7 EDN04324.1 - 1.9 8.7 9.9 1.3 9.2 6.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3784) SdpI PF13630.6 EDN04324.1 - 3 8.1 7.0 5.1 7.3 3.4 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF1840 PF08895.11 EDN04325.1 - 1.5 9.2 0.0 1.5 9.2 0.0 3.4 4 1 0 4 4 4 0 Domain of unknown function (DUF1840) TACC_C PF05010.14 EDN04325.1 - 2.8 7.7 9.9 0.17 11.6 2.9 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal YabA PF06156.13 EDN04325.1 - 7.2 7.3 6.2 0.86 10.3 1.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA Cmc1 PF08583.10 EDN04326.1 - 0.064 13.3 2.2 0.15 12.1 2.2 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like WD40 PF00400.32 EDN04329.1 - 3.4e-15 56.2 8.7 0.00037 21.2 0.1 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04329.1 - 5e-14 52.4 0.0 1.2e-06 28.7 0.0 4.5 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN04329.1 - 0.00051 20.0 0.2 0.059 13.2 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A HIRA_B PF09453.10 EDN04329.1 - 0.008 16.0 2.2 0.013 15.3 0.1 2.5 2 0 0 2 2 2 1 HIRA B motif Ge1_WD40 PF16529.5 EDN04329.1 - 0.015 14.2 0.1 4 6.3 0.0 3.1 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EDN04329.1 - 0.089 12.8 6.2 8.1 6.5 0.3 4.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Metallophos PF00149.28 EDN04330.1 - 4.3e-30 105.7 0.1 6.5e-30 105.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDN04330.1 - 8.2e-17 61.4 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Pneumo_att_G PF05539.11 EDN04330.1 - 4.4 6.8 9.5 8.8 5.8 9.5 1.5 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Abhydrolase_6 PF12697.7 EDN04331.1 - 1.4e-12 48.7 2.5 2.1e-12 48.1 2.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN04331.1 - 3.6e-08 33.0 0.2 6e-08 32.2 0.2 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDN04331.1 - 0.028 14.1 0.2 0.043 13.5 0.2 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold TGT PF01702.18 EDN04332.1 - 5.2e-126 420.5 0.1 3.4e-92 309.3 0.1 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase Thymidylat_synt PF00303.19 EDN04333.1 - 1.1e-84 283.8 0.0 1.4e-84 283.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase zf-AN1 PF01428.16 EDN04334.1 - 8.3e-24 83.5 30.1 4.2e-12 46.0 10.8 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EDN04334.1 - 0.0051 17.0 6.3 0.0051 17.0 6.3 2.6 2 1 0 2 2 2 2 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 EDN04334.1 - 0.11 12.9 16.6 0.078 13.4 4.6 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain C1_4 PF07975.12 EDN04334.1 - 0.57 10.4 15.2 1.1 9.5 5.6 2.8 2 0 0 2 2 2 0 TFIIH C1-like domain Hist_deacetyl PF00850.19 EDN04336.1 - 4e-22 79.1 0.1 6.1e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain RTP801_C PF07809.11 EDN04336.1 - 0.029 14.3 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 RTP801 C-terminal region R3H-assoc PF13902.6 EDN04338.1 - 7.5e-17 62.0 3.3 7.5e-17 62.0 3.3 2.4 2 1 0 2 2 2 1 R3H-associated N-terminal domain R3H PF01424.22 EDN04338.1 - 0.0087 16.0 0.1 0.24 11.4 0.0 2.5 2 0 0 2 2 2 1 R3H domain Peptidase_M28 PF04389.17 EDN04339.1 - 4.9e-30 104.7 0.1 7.2e-30 104.2 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDN04339.1 - 3e-06 27.1 0.1 5.9e-06 26.1 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Ecm29 PF13001.7 EDN04339.1 - 0.0027 16.5 0.0 0.0033 16.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome stabiliser Peptidase_M42 PF05343.14 EDN04339.1 - 0.0062 15.6 0.3 1.3 8.0 0.1 2.4 2 1 0 2 2 2 2 M42 glutamyl aminopeptidase DUF1774 PF08611.10 EDN04340.1 - 6.7e-32 109.7 1.6 6.7e-32 109.7 1.6 2.1 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1774) Chitin_synth_1 PF01644.17 EDN04342.1 - 2.7e-77 258.3 0.0 3.9e-77 257.8 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDN04342.1 - 2.9e-27 94.4 0.2 6.3e-27 93.3 0.2 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDN04342.1 - 2.7e-22 79.1 1.3 1.3e-20 73.5 0.0 2.4 1 1 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EDN04342.1 - 1.7e-07 31.3 0.5 1.7e-07 31.3 0.5 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDN04342.1 - 0.052 13.4 0.0 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase like family 2 DHHC PF01529.20 EDN04342.1 - 9.5 6.3 18.8 1.5 8.9 7.7 3.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase AFG1_ATPase PF03969.16 EDN04344.1 - 3.6e-94 315.6 0.0 1.6e-89 300.3 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EDN04344.1 - 0.0005 20.5 0.1 0.53 10.6 0.0 3.3 2 1 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 EDN04344.1 - 0.0016 18.4 0.0 0.004 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDN04344.1 - 0.0064 16.8 0.0 0.025 14.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDN04344.1 - 0.016 15.6 0.0 0.047 14.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDN04344.1 - 0.05 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Phage_C PF12025.8 EDN04344.1 - 0.084 12.7 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Phage protein C NACHT PF05729.12 EDN04344.1 - 0.1 12.5 0.0 0.74 9.7 0.0 2.4 3 0 0 3 3 3 0 NACHT domain RNA_helicase PF00910.22 EDN04344.1 - 0.11 12.9 0.0 0.58 10.6 0.0 2.2 2 0 0 2 2 2 0 RNA helicase DUF2457 PF10446.9 EDN04345.1 - 1.1 8.4 16.1 1.5 7.9 16.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GREB1 PF15782.5 EDN04345.1 - 4.4 4.3 10.4 5.2 4.1 10.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lactamase_B PF00753.27 EDN04346.1 - 2.8e-18 66.6 2.1 9.6e-17 61.6 2.1 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EDN04346.1 - 3.6e-16 58.9 0.0 6.5e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EDN04346.1 - 1.7e-07 30.9 0.1 3.3e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EDN04346.1 - 0.04 13.4 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDN04346.1 - 0.084 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain SH3_1 PF00018.28 EDN04348.1 - 1.4e-23 82.2 0.0 2.2e-11 43.2 0.0 3.1 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EDN04348.1 - 1.5e-13 50.3 0.0 8.7e-06 25.5 0.0 2.8 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EDN04348.1 - 3.2e-13 49.7 0.0 6.5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EDN04348.1 - 6.9e-09 35.3 0.0 9.8e-05 22.0 0.0 3.0 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EDN04348.1 - 2.6e-08 33.7 0.1 4.9e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 PB1 domain SAC3_GANP PF03399.16 EDN04349.1 - 2.4e-24 86.3 0.9 2.7e-22 79.5 0.9 2.2 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EDN04349.1 - 5e-05 23.3 0.1 0.00014 21.8 0.0 1.7 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family EAP30 PF04157.16 EDN04350.1 - 4.1e-43 147.4 0.2 5.4e-43 147.0 0.2 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 EDN04350.1 - 1.2e-24 86.3 0.0 1.9e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Vps36-NZF-N PF16988.5 EDN04350.1 - 9.8e-22 76.1 1.9 9.8e-22 76.1 1.9 2.5 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 EDN04350.1 - 0.00013 21.9 1.9 0.02 14.9 0.1 2.4 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EDN04350.1 - 0.001 18.3 12.3 0.01 15.1 1.2 2.7 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others DZR PF12773.7 EDN04350.1 - 0.04 13.9 4.6 0.12 12.4 0.5 2.4 2 0 0 2 2 2 0 Double zinc ribbon GRAM PF02893.20 EDN04350.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 GRAM domain zf-C2H2_4 PF13894.6 EDN04350.1 - 3.4 8.8 5.1 1e+02 4.1 0.2 3.5 2 1 1 3 3 3 0 C2H2-type zinc finger MFS_1 PF07690.16 EDN04351.1 - 3.5e-09 36.1 5.8 5.3e-09 35.5 5.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MAT1 PF06391.13 EDN04351.1 - 3.9 7.3 5.8 2.4 8.0 3.2 1.9 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 FKBP_C PF00254.28 EDN04355.1 - 3e-22 78.7 0.0 8e-22 77.4 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase MBA1 PF07961.11 EDN04355.1 - 0.063 12.3 0.0 0.082 12.0 0.0 1.1 1 0 0 1 1 1 0 MBA1-like protein FKBP_N_2 PF18023.1 EDN04355.1 - 0.068 13.3 0.0 0.99 9.5 0.0 2.5 2 1 0 2 2 2 0 BDBT FKBP like N-terminal PHP PF02811.19 EDN04357.1 - 2.7e-07 31.0 0.0 7.2e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 PHP domain ACPS PF01648.20 EDN04358.1 - 2.4e-11 43.8 0.0 3e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily AAT PF03417.16 EDN04359.1 - 3.8e-29 102.0 0.0 5e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase ATP19 PF11022.8 EDN04360.1 - 1.5e-24 86.1 0.0 1.7e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K MTP18 PF10558.9 EDN04361.1 - 2.6e-81 271.7 1.8 2.6e-81 271.6 0.1 1.8 2 1 0 2 2 2 1 Mitochondrial 18 KDa protein (MTP18) Cys_Met_Meta_PP PF01053.20 EDN04363.1 - 3.2e-141 470.3 0.0 3.8e-141 470.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EDN04363.1 - 0.0025 17.2 0.0 0.0087 15.4 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 EDN04363.1 - 0.0028 16.3 0.0 0.028 13.0 0.0 2.0 1 1 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.21 EDN04363.1 - 0.14 11.4 0.0 0.41 9.9 0.0 1.7 2 0 0 2 2 2 0 Beta-eliminating lyase AAA PF00004.29 EDN04364.1 - 4.2e-37 127.5 0.0 9.3e-37 126.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN04364.1 - 7.9e-09 35.2 0.0 1.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDN04364.1 - 2.3e-05 24.4 0.1 0.00031 20.8 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN04364.1 - 3e-05 24.5 0.5 0.00029 21.3 0.1 2.5 2 1 0 2 2 1 1 AAA ATPase domain RuvB_N PF05496.12 EDN04364.1 - 3.4e-05 23.7 0.0 6.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EDN04364.1 - 4.2e-05 23.6 0.0 9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EDN04364.1 - 0.00022 21.4 0.0 0.0005 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EDN04364.1 - 0.00031 21.0 0.4 0.0069 16.7 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EDN04364.1 - 0.00067 19.8 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EDN04364.1 - 0.0007 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EDN04364.1 - 0.001 19.4 0.0 0.0047 17.3 0.0 2.2 2 1 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.21 EDN04364.1 - 0.0011 18.4 0.1 0.0021 17.5 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDN04364.1 - 0.0011 19.5 0.1 0.0034 17.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDN04364.1 - 0.0016 18.1 0.1 0.027 14.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EDN04364.1 - 0.002 17.6 0.0 3.2 7.1 0.0 2.9 1 1 1 3 3 3 2 Bacterial TniB protein Parvo_NS1 PF01057.17 EDN04364.1 - 0.0042 16.2 0.0 0.0062 15.7 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 NACHT PF05729.12 EDN04364.1 - 0.0051 16.7 0.0 0.016 15.1 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 EDN04364.1 - 0.0088 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDN04364.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EDN04364.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Rad17 PF03215.15 EDN04364.1 - 0.014 15.3 0.1 0.045 13.7 0.1 1.7 1 1 1 2 2 2 0 Rad17 P-loop domain Sigma54_activat PF00158.26 EDN04364.1 - 0.018 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.6 EDN04364.1 - 0.02 14.7 0.4 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDN04364.1 - 0.027 15.0 0.5 0.095 13.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 EDN04364.1 - 0.052 13.1 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 EDN04364.1 - 0.069 12.3 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CPT PF07931.12 EDN04364.1 - 0.074 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ATPase_2 PF01637.18 EDN04364.1 - 0.077 12.9 0.0 0.25 11.2 0.0 1.7 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 EDN04364.1 - 0.092 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDN04364.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_6 PF12774.7 EDN04364.1 - 0.14 11.1 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Viral_helicase1 PF01443.18 EDN04364.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TIP49 PF06068.13 EDN04364.1 - 0.17 11.1 0.0 0.38 9.9 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain Csm1 PF12539.8 EDN04365.1 - 1.4e-31 109.0 0.3 4e-31 107.5 0.1 1.9 2 0 0 2 2 1 1 Chromosome segregation protein Csm1/Pcs1 PKcGMP_CC PF16808.5 EDN04365.1 - 0.0025 17.6 3.7 0.019 14.8 3.2 2.7 1 1 1 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4201 PF13870.6 EDN04365.1 - 0.0043 16.8 13.8 0.01 15.6 13.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) Rootletin PF15035.6 EDN04365.1 - 0.0077 16.3 8.7 0.0077 16.3 8.7 2.2 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion EzrA PF06160.12 EDN04365.1 - 0.0086 14.3 10.8 0.014 13.6 10.8 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Tropomyosin_1 PF12718.7 EDN04365.1 - 0.022 14.9 5.8 0.022 14.9 5.8 3.8 2 1 2 4 4 4 0 Tropomyosin like USP8_interact PF08941.10 EDN04365.1 - 0.17 11.7 0.1 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 USP8 interacting Bacillus_HBL PF05791.11 EDN04365.1 - 0.18 11.6 6.3 0.45 10.3 6.3 1.6 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Baculo_PEP_C PF04513.12 EDN04365.1 - 0.25 11.4 6.8 0.17 11.9 4.8 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CHDCT2 PF08074.11 EDN04365.1 - 1.4 9.1 4.6 3.6 7.7 4.6 1.7 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Cob_adeno_trans PF01923.18 EDN04365.1 - 2.4 8.3 9.2 0.084 13.0 2.8 1.8 2 0 0 2 2 2 0 Cobalamin adenosyltransferase DUF1664 PF07889.12 EDN04365.1 - 2.8 8.0 5.3 5.1 7.1 3.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 EDN04365.1 - 6 7.4 25.1 1.3 9.5 11.1 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF501 PF04417.12 EDN04365.1 - 6.3 6.6 8.9 0.18 11.6 1.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF501) Seryl_tRNA_N PF02403.22 EDN04365.1 - 8.8 6.6 21.1 0.17 12.1 8.6 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PigN PF04987.14 EDN04366.1 - 9e-134 446.8 43.8 1.7e-98 330.5 19.7 2.4 2 1 1 3 3 3 2 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EDN04366.1 - 5.4e-09 36.1 2.7 9.4e-08 32.0 2.7 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDN04366.1 - 9.2e-09 35.1 0.0 1.7e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EDN04366.1 - 4.7e-05 22.9 0.0 7.9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Fungal_trans PF04082.18 EDN04368.1 - 7.2e-33 113.8 0.0 7.2e-33 113.8 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain SH2_2 PF14633.6 EDN04368.1 - 0.86 9.0 3.0 1.6 8.0 3.0 1.3 1 0 0 1 1 1 0 SH2 domain cNMPbd_u2 PF16643.5 EDN04370.1 - 2.5 8.6 7.1 0.55 10.7 3.3 1.8 2 0 0 2 2 2 0 Unstructured region on cNMP-binding protein AAA_18 PF13238.6 EDN04372.1 - 0.044 14.3 1.0 1.4 9.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EDN04372.1 - 0.09 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE adh_short PF00106.25 EDN04373.1 - 2.5e-83 278.3 8.0 6.9e-46 156.2 0.3 2.9 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN04373.1 - 2.8e-65 220.2 5.1 6.6e-36 124.0 0.5 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EDN04373.1 - 7.8e-32 109.4 0.0 1.5e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EDN04373.1 - 7.2e-27 94.5 2.3 8.3e-14 51.9 0.1 2.3 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EDN04373.1 - 5.4e-06 25.8 0.4 0.00032 20.1 0.4 2.4 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glu_dehyd_C PF16912.5 EDN04373.1 - 0.0085 15.6 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ELFV_dehydrog PF00208.21 EDN04373.1 - 0.13 12.0 0.7 0.33 10.6 0.1 2.0 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Glucodextran_B PF09136.10 EDN04373.1 - 0.14 12.6 2.0 0.25 11.7 0.1 2.5 2 0 0 2 2 2 0 Glucodextranase, domain B NAD_binding_7 PF13241.6 EDN04373.1 - 0.3 11.5 1.4 8 7.0 0.2 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Epimerase PF01370.21 EDN04373.1 - 0.63 9.4 3.7 15 4.9 0.0 3.3 3 1 0 3 3 3 0 NAD dependent epimerase/dehydratase family DUF543 PF04418.12 EDN04373.1 - 0.95 9.5 4.7 18 5.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF543) PglL_A PF15864.5 EDN04373.1 - 1.2 8.9 6.6 5.5 6.8 1.0 2.4 2 0 0 2 2 2 0 Protein glycosylation ligase Yip1 PF04893.17 EDN04375.1 - 9.5e-13 48.2 19.7 1.7e-12 47.4 19.7 1.4 1 1 0 1 1 1 1 Yip1 domain Ran_BP1 PF00638.18 EDN04376.1 - 1e-13 51.6 0.0 2.6e-07 30.9 0.1 2.5 2 0 0 2 2 2 2 RanBP1 domain DEAD PF00270.29 EDN04377.1 - 3.8e-28 98.4 0.0 6.2e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EDN04377.1 - 1.3e-19 70.8 0.1 3.1e-19 69.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EDN04377.1 - 1.6e-12 47.7 0.1 5.1e-12 46.1 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN04377.1 - 4e-05 23.7 0.0 7.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 EDN04377.1 - 0.041 14.2 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 DNA replication factor CDT1 like Fungal_trans_2 PF11951.8 EDN04378.1 - 1.4e-10 40.5 0.3 2.5e-10 39.8 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-RING_2 PF13639.6 EDN04379.1 - 2.3e-12 47.1 6.3 3.6e-12 46.4 6.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDN04379.1 - 5.3e-09 36.2 3.8 5.3e-09 36.2 3.8 1.8 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDN04379.1 - 5.7e-08 32.5 4.8 9.7e-08 31.7 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN04379.1 - 1.1e-07 31.5 5.8 1.9e-07 30.8 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDN04379.1 - 9.2e-07 28.5 3.8 1.9e-06 27.5 3.8 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EDN04379.1 - 1.4e-05 25.0 4.2 2.2e-05 24.3 4.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDN04379.1 - 0.00011 22.0 3.1 0.00019 21.2 3.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDN04379.1 - 0.00014 21.8 4.4 0.0003 20.7 4.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EDN04379.1 - 0.00015 21.3 3.0 0.00024 20.7 3.0 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EDN04379.1 - 0.00038 20.4 2.9 0.0013 18.7 2.9 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EDN04379.1 - 0.00088 19.1 3.8 0.0015 18.4 3.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 EDN04379.1 - 0.011 15.8 7.1 0.019 15.1 7.1 1.4 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EDN04379.1 - 0.023 14.5 2.2 0.062 13.1 2.2 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 EDN04379.1 - 0.027 14.6 4.1 0.053 13.7 4.1 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3H2C3 PF17122.5 EDN04379.1 - 0.04 14.0 3.0 0.082 13.0 3.0 1.5 1 0 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.6 EDN04379.1 - 0.12 12.2 2.2 0.24 11.2 2.2 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 EDN04379.1 - 0.19 11.6 1.6 0.37 10.7 1.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.5 EDN04379.1 - 0.32 11.1 2.6 0.59 10.3 2.6 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 EDN04379.1 - 0.39 10.7 4.5 0.29 11.1 2.5 1.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 EDN04379.1 - 0.64 10.0 4.6 1.1 9.2 4.6 1.4 1 0 0 1 1 1 0 PHD-finger RNA_pol_I_TF PF04090.12 EDN04380.1 - 4.1e-09 36.2 0.0 8.2e-08 32.0 0.0 2.3 1 1 0 1 1 1 1 RNA polymerase I specific initiation factor HMW1C_N PF18071.1 EDN04380.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 HMW1C N-terminal ECM11 PF15463.6 EDN04381.1 - 5.3e-28 98.2 1.7 7.2e-28 97.8 0.2 2.0 2 0 0 2 2 2 1 Extracellular mutant protein 11 VPS9 PF02204.18 EDN04382.1 - 5.9e-25 87.5 0.1 1.3e-24 86.4 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EDN04382.1 - 0.13 12.6 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) Lipase_3 PF01764.25 EDN04383.1 - 2.6e-06 27.4 0.0 4.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EDN04383.1 - 0.0037 17.0 0.5 0.098 12.4 0.0 2.2 2 0 0 2 2 2 1 PGAP1-like protein Hydrolase_4 PF12146.8 EDN04383.1 - 0.028 13.7 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDN04383.1 - 0.031 13.9 0.1 0.068 12.8 0.1 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EDN04383.1 - 0.07 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.12 EDN04383.1 - 0.071 13.0 0.2 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.7 EDN04383.1 - 0.75 10.4 4.4 0.62 10.6 2.6 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family PAS_3 PF08447.12 EDN04385.1 - 8.4e-11 42.0 0.0 2e-07 31.2 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EDN04385.1 - 9.1e-07 28.9 0.0 0.023 14.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EDN04385.1 - 1.4e-06 28.5 0.0 0.027 14.7 0.0 2.6 2 1 0 2 2 2 2 PAS domain PAS_11 PF14598.6 EDN04385.1 - 3.3e-05 24.0 0.0 0.00012 22.2 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EDN04385.1 - 0.00048 20.4 0.0 0.12 12.7 0.0 2.3 2 0 0 2 2 2 2 PAS fold DUF3419 PF11899.8 EDN04386.1 - 3.4e-161 536.7 0.0 5.2e-161 536.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EDN04386.1 - 2.4e-14 53.5 0.0 1.2e-12 48.0 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04386.1 - 3e-10 40.7 0.0 1.5e-07 32.0 0.0 3.3 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN04386.1 - 9.4e-10 39.1 0.0 2.5e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN04386.1 - 8.4e-09 36.0 0.0 4.4e-06 27.3 0.0 3.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN04386.1 - 5.1e-07 29.6 0.0 2e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN04386.1 - 8.1e-05 22.1 0.0 0.15 11.3 0.0 2.4 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EDN04386.1 - 0.0033 17.2 0.0 0.0064 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EDN04386.1 - 0.02 14.4 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.6 EDN04386.1 - 0.05 13.6 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Spo7_2_N PF15407.6 EDN04386.1 - 0.74 9.5 2.8 0.95 9.1 0.0 2.6 3 0 0 3 3 3 0 Sporulation protein family 7 Methyltransf_2 PF00891.18 EDN04387.1 - 2.4e-25 89.1 0.0 3.7e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EDN04387.1 - 0.002 18.8 0.0 0.0053 17.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN04387.1 - 0.066 13.9 0.0 0.15 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EDN04387.1 - 0.18 12.6 0.0 0.43 11.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_1 PF00583.25 EDN04389.1 - 0.011 15.9 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Mur_ligase_C PF02875.21 EDN04389.1 - 0.025 14.8 0.0 0.075 13.3 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain A_deaminase PF00962.22 EDN04390.1 - 1.6e-22 80.3 0.0 2.4e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase ECH_1 PF00378.20 EDN04392.1 - 4.4e-77 258.8 0.0 5e-77 258.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN04392.1 - 3.2e-37 128.8 0.2 3.4e-34 118.8 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Rer1 PF03248.13 EDN04393.1 - 6.4e-79 263.6 4.2 7.4e-79 263.4 4.2 1.0 1 0 0 1 1 1 1 Rer1 family Fungal_trans_2 PF11951.8 EDN04394.1 - 0.00068 18.5 0.2 0.00094 18.1 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF898 PF05987.13 EDN04394.1 - 0.052 12.6 0.0 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Helicase_C PF00271.31 EDN04395.1 - 0.00019 21.8 0.2 0.00037 20.8 0.2 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Catalase PF00199.19 EDN04398.1 - 3.2e-195 648.6 0.1 4.2e-195 648.2 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDN04398.1 - 2.2e-09 37.4 0.0 6.6e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF4879 PF16219.5 EDN04399.1 - 0.024 14.9 0.0 0.026 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4879) Sugar_tr PF00083.24 EDN04400.1 - 3.8e-99 332.6 20.9 4.9e-99 332.2 20.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN04400.1 - 3.4e-25 88.7 48.4 5e-24 84.9 24.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Arf PF00025.21 EDN04401.1 - 9.2e-75 249.9 0.0 1e-74 249.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDN04401.1 - 6.4e-14 52.2 0.0 8.6e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDN04401.1 - 9.7e-12 44.7 0.0 1.2e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDN04401.1 - 1.2e-10 41.2 0.0 1.4e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDN04401.1 - 2.1e-10 40.3 0.4 2.8e-06 26.7 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDN04401.1 - 2.2e-08 33.8 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDN04401.1 - 2.7e-06 27.5 0.0 4.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDN04401.1 - 0.00057 19.5 0.0 0.045 13.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EDN04401.1 - 0.0042 16.6 0.4 0.019 14.5 0.4 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EDN04401.1 - 0.13 12.8 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Actin PF00022.19 EDN04402.1 - 1.6e-30 106.1 0.0 9.9e-17 60.6 0.0 2.9 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 EDN04402.1 - 1.1e-05 24.8 0.1 0.0081 15.4 0.1 2.3 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 EDN04402.1 - 0.0011 17.9 0.0 0.11 11.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDN04402.1 - 0.0024 18.3 0.0 0.0064 16.9 0.0 1.8 1 0 0 1 1 1 1 Cell division protein FtsA Paf1 PF03985.13 EDN04403.1 - 1e-54 186.2 0.0 1.5e-54 185.6 0.0 1.3 1 0 0 1 1 1 1 Paf1 RICTOR_N PF14664.6 EDN04404.1 - 5.2e-128 427.2 0.0 1.2e-127 426.0 0.0 1.7 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 EDN04404.1 - 5e-39 133.0 0.5 9.4e-36 122.5 0.0 3.9 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EDN04404.1 - 2.1e-38 130.2 3.6 8.9e-36 121.8 0.3 4.4 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EDN04404.1 - 1.5e-25 89.2 1.4 6.9e-24 83.9 0.1 3.8 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 EDN04404.1 - 1.4e-12 47.6 12.2 3.4e-12 46.3 12.2 1.7 1 0 0 1 1 1 1 Hr1 repeat Uricase PF01014.18 EDN04405.1 - 5.5e-81 269.3 1.8 6.6e-45 152.6 0.4 2.0 2 0 0 2 2 2 2 Uricase Ribosomal_L13 PF00572.18 EDN04406.1 - 2.6e-41 140.8 0.0 3.4e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Ribosomal_S9 PF00380.19 EDN04407.1 - 1e-33 116.4 0.4 1.2e-33 116.2 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 PilJ PF13675.6 EDN04407.1 - 0.11 12.5 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term AAR2 PF05282.11 EDN04408.1 - 2.9e-85 286.8 1.1 8.4e-66 222.8 0.0 2.9 1 1 1 2 2 2 2 AAR2 protein DUF4604 PF15377.6 EDN04408.1 - 0.045 14.2 3.6 0.055 13.9 0.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4604) Ribosomal_S11 PF00411.19 EDN04409.1 - 2.1e-46 156.8 1.1 2.6e-46 156.5 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EDN04409.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) PDH PF02153.17 EDN04410.1 - 3e-14 52.6 0.0 4.3e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase CDH-cyt PF16010.5 EDN04412.1 - 3.9e-25 88.6 0.0 6.5e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EDN04412.1 - 0.0001 22.4 8.2 0.00025 21.2 8.2 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.17 EDN04412.1 - 0.00054 20.2 0.0 0.0015 18.7 0.0 1.7 2 0 0 2 2 2 1 DOMON domain DUF2427 PF10348.9 EDN04412.1 - 5.1 7.0 8.0 0.18 11.6 1.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) Paf67 PF10255.9 EDN04414.1 - 3.2e-117 392.0 0.0 3.8e-117 391.7 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EDN04414.1 - 0.0095 16.0 0.0 0.1 12.8 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDN04414.1 - 0.057 13.3 0.0 0.64 9.9 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDN04414.1 - 0.092 13.0 0.0 3.7 7.9 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Fe-S_biosyn PF01521.20 EDN04415.1 - 5.9e-08 32.9 0.0 2.5e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Hemerythrin PF01814.23 EDN04416.1 - 5.2e-09 36.8 3.3 5.4e-09 36.7 2.5 1.5 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain TCTP PF00838.17 EDN04416.1 - 0.065 13.6 0.1 0.078 13.3 0.1 1.2 1 0 0 1 1 1 0 Translationally controlled tumour protein DUF4531 PF15041.6 EDN04416.1 - 0.14 12.2 0.0 1.4 9.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4531) MFS_1 PF07690.16 EDN04417.1 - 1.1e-30 106.8 23.6 1.1e-30 106.8 23.6 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EDN04417.1 - 0.013 14.3 1.9 0.024 13.5 1.9 1.4 1 0 0 1 1 1 0 MFS_1 like family DUF1772 PF08592.11 EDN04417.1 - 0.67 10.3 6.9 9.6 6.5 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Lactamase_B PF00753.27 EDN04418.1 - 1.3e-06 28.6 0.0 4.3e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDN04418.1 - 0.097 12.2 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Adaptin_N PF01602.20 EDN04421.1 - 1.2e-97 327.7 11.0 1.2e-95 321.1 11.0 2.0 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDN04421.1 - 1.6e-42 145.3 6.5 6.4e-32 110.8 0.1 4.4 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN04421.1 - 8.5e-09 35.7 5.6 0.032 14.6 0.0 5.5 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 EDN04421.1 - 0.00017 21.6 3.0 0.33 11.3 0.1 5.2 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 EDN04421.1 - 0.018 15.6 9.2 5.8 7.5 0.2 5.8 7 0 0 7 7 7 0 HEAT-like repeat Atx10homo_assoc PF09759.9 EDN04421.1 - 0.025 14.6 0.1 21 5.2 0.0 3.9 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EDN04421.1 - 0.19 11.8 4.0 12 6.2 0.0 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF1077 PF06417.12 EDN04422.1 - 6.6e-31 106.8 7.8 1.1e-30 106.0 2.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1077) MFS_1 PF07690.16 EDN04423.1 - 4e-38 131.2 14.2 4e-38 131.2 14.2 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN04423.1 - 4.5e-11 42.3 5.7 4.5e-11 42.3 5.7 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_4 PF06779.14 EDN04423.1 - 6.4e-07 29.0 5.4 6.4e-07 29.0 5.4 2.8 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB CPP1-like PF11833.8 EDN04423.1 - 9.6e-05 22.1 0.6 0.00021 21.0 0.6 1.6 1 0 0 1 1 1 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like OATP PF03137.20 EDN04423.1 - 0.00021 19.7 1.2 0.00048 18.6 1.2 1.7 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family TRI12 PF06609.13 EDN04423.1 - 0.0023 16.4 0.7 0.0023 16.4 0.7 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EDN04423.1 - 0.0026 16.7 8.0 0.023 13.6 2.5 3.3 1 1 1 2 2 2 2 MFS_1 like family SH3_2 PF07653.17 EDN04424.1 - 3.9e-11 42.5 0.1 7.9e-11 41.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDN04424.1 - 6.7e-10 38.4 0.2 1.5e-09 37.3 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN04424.1 - 1.1e-08 34.8 0.2 2.1e-08 33.9 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain RPAP2_Rtr1 PF04181.13 EDN04425.1 - 1.7e-21 76.3 0.0 3.3e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family Dicty_REP PF05086.12 EDN04425.1 - 0.28 9.1 0.9 0.4 8.6 0.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EDN04425.1 - 0.65 8.1 3.0 0.91 7.6 3.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ribosomal_S17e PF00833.18 EDN04426.1 - 3.4e-60 201.3 0.5 4.1e-60 201.1 0.5 1.0 1 0 0 1 1 1 1 Ribosomal S17 Mit_ribos_Mrp51 PF11709.8 EDN04427.1 - 1.2e-122 410.0 0.0 1.5e-122 409.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Adeno_E1A PF02703.14 EDN04427.1 - 0.075 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Early E1A protein FAT PF02259.23 EDN04428.1 - 1e-137 459.0 0.7 1e-137 459.0 0.7 2.0 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EDN04428.1 - 1.1e-68 231.7 0.2 2.2e-68 230.8 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EDN04428.1 - 3.1e-68 228.7 5.2 4.3e-63 212.0 1.6 4.5 4 0 0 4 4 4 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EDN04428.1 - 1.2e-41 141.1 0.2 1.8e-40 137.3 0.0 3.1 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain HEAT_EZ PF13513.6 EDN04428.1 - 3.1e-16 59.5 10.0 7.9e-05 23.1 0.1 9.8 8 1 2 10 10 9 3 HEAT-like repeat HEAT_2 PF13646.6 EDN04428.1 - 1.2e-14 54.5 7.5 9.6e-05 22.7 0.0 7.6 6 2 1 7 7 7 3 HEAT repeats FATC PF02260.20 EDN04428.1 - 1.3e-14 53.7 0.3 4.2e-14 52.1 0.3 2.0 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 EDN04428.1 - 1.2e-12 46.9 21.8 0.00045 20.2 0.1 11.8 13 0 0 13 13 13 2 HEAT repeat UME PF08064.13 EDN04428.1 - 0.00033 20.5 1.2 2.9 7.8 0.0 5.5 5 1 1 6 6 5 1 UME (NUC010) domain MMS19_C PF12460.8 EDN04428.1 - 0.00054 19.2 5.6 0.034 13.3 0.1 4.5 4 1 0 4 4 4 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EDN04428.1 - 0.002 17.7 0.1 17 4.9 0.0 5.1 4 1 1 5 5 5 0 CLASP N terminal Dopey_N PF04118.14 EDN04428.1 - 0.0098 15.0 2.0 0.18 10.9 0.3 3.3 3 0 0 3 3 3 1 Dopey, N-terminal Sec7_N PF12783.7 EDN04428.1 - 0.064 13.2 0.8 3.5 7.5 0.0 3.6 4 0 0 4 4 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_19 PF14559.6 EDN04428.1 - 0.15 12.6 5.8 16 6.1 0.0 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN04428.1 - 0.19 12.0 0.5 55 4.1 0.0 4.2 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EDN04428.1 - 0.25 12.2 8.8 33 5.7 0.1 5.6 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDN04428.1 - 1.3 8.7 4.3 2 8.1 0.0 3.5 4 0 0 4 4 4 0 TPR repeat Methyltransf_25 PF13649.6 EDN04430.1 - 5.3e-10 39.9 0.0 1.1e-09 38.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN04430.1 - 3.3e-09 37.4 0.0 5.5e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN04430.1 - 1.6e-08 35.1 0.0 4.2e-08 33.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN04430.1 - 2e-08 34.2 0.0 3.1e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN04430.1 - 3.8e-08 33.3 0.0 5.1e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EDN04430.1 - 0.00036 20.2 0.0 0.00057 19.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN04430.1 - 0.00049 19.6 0.1 0.0015 18.0 0.0 1.7 1 1 1 2 2 2 1 short chain dehydrogenase Methyltransf_16 PF10294.9 EDN04430.1 - 0.00081 19.2 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase TehB PF03848.14 EDN04430.1 - 0.0023 17.4 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 EDN04430.1 - 0.0035 16.9 0.1 0.0071 15.9 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Pox_MCEL PF03291.16 EDN04430.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme DUF2523 PF10734.9 EDN04430.1 - 0.018 15.6 0.1 0.043 14.4 0.0 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2523) KR PF08659.10 EDN04430.1 - 0.033 14.1 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 KR domain DREV PF05219.12 EDN04430.1 - 0.039 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase CMAS PF02353.20 EDN04430.1 - 0.093 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EDN04430.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TPMT PF05724.11 EDN04430.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NAD_binding_10 PF13460.6 EDN04433.1 - 1.1e-20 74.4 0.0 1.8e-16 60.6 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding Epimerase PF01370.21 EDN04433.1 - 0.0088 15.5 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDN04433.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Pex24p PF06398.11 EDN04434.1 - 2.4e-36 125.5 11.7 3.2e-36 125.1 11.7 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF5544 PF17698.1 EDN04434.1 - 0.049 13.7 4.1 0.096 12.8 1.5 2.1 1 1 0 2 2 2 0 Family of unknown function (DUF5544) Pam16 PF03656.13 EDN04435.1 - 5.6e-36 123.4 0.9 6.5e-36 123.1 0.9 1.0 1 0 0 1 1 1 1 Pam16 Aldo_ket_red PF00248.21 EDN04437.1 - 2.8e-76 256.5 0.0 3.7e-76 256.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family XRCC4 PF06632.12 EDN04437.1 - 0.071 12.0 0.2 0.1 11.4 0.2 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 PAP_assoc PF03828.19 EDN04438.1 - 1.1e-12 48.0 0.2 2.2e-12 47.0 0.2 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EDN04438.1 - 1.3e-10 41.4 0.0 5.2e-10 39.5 0.0 2.0 1 1 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDN04438.1 - 0.12 12.5 0.0 1.1 9.5 0.0 2.4 2 1 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase IHHNV_capsid PF16530.5 EDN04438.1 - 0.21 10.7 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 Infectious hypodermal and haematopoietic necrosis virus, capsid CAP_N PF01213.19 EDN04438.1 - 7.6 5.9 9.0 18 4.7 9.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Tom37 PF10568.9 EDN04439.1 - 0.084 13.2 0.3 0.19 12.0 0.2 1.7 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein NmrA PF05368.13 EDN04440.1 - 8.1e-43 146.6 0.0 1.3e-42 146.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN04440.1 - 2.2e-15 57.0 0.1 3.8e-15 56.3 0.0 1.4 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EDN04440.1 - 1.4e-05 24.6 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN04440.1 - 0.00049 19.2 0.0 0.00075 18.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EDN04440.1 - 0.15 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain DUF4357 PF14267.6 EDN04441.1 - 0.02 14.8 0.1 0.041 13.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) Cauli_DNA-bind PF03310.13 EDN04443.1 - 0.083 13.0 0.2 0.12 12.5 0.2 1.2 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein PRKCSH-like PF12999.7 EDN04444.1 - 1.2e-40 139.2 12.6 1.3e-38 132.5 12.6 2.6 1 1 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EDN04444.1 - 4.8e-31 107.5 1.3 1.6e-30 105.9 0.2 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EDN04444.1 - 2.9e-12 47.4 0.6 1e-11 45.7 0.6 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EDN04444.1 - 0.00018 21.5 1.4 0.00041 20.3 1.4 1.6 1 0 0 1 1 1 1 Autophagy-related protein 27 Rab5-bind PF09311.11 EDN04444.1 - 0.017 14.5 7.5 0.029 13.8 7.5 1.3 1 0 0 1 1 1 0 Rabaptin-like protein KfrA_N PF11740.8 EDN04444.1 - 0.88 10.3 10.1 31 5.3 0.0 3.4 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Fib_alpha PF08702.10 EDN04444.1 - 0.89 9.7 4.3 4 7.6 1.3 2.6 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family CbiX PF01903.17 EDN04444.1 - 1.4 9.3 3.3 1.8 8.9 0.5 2.5 3 0 0 3 3 3 0 CbiX Rtf2 PF04641.12 EDN04445.1 - 1.7e-57 194.8 0.3 2.1e-57 194.5 0.3 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EDN04445.1 - 7e-09 35.4 0.2 0.0035 17.1 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDN04445.1 - 0.00095 19.1 0.3 0.0022 18.0 0.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDN04445.1 - 0.0025 17.8 0.1 0.0053 16.7 0.1 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EDN04445.1 - 0.04 14.2 0.2 0.085 13.2 0.2 1.6 1 0 0 1 1 1 0 Ring finger domain zf-NOSIP PF15906.5 EDN04445.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Prok-RING_4 PF14447.6 EDN04445.1 - 0.12 12.3 1.2 5 7.1 0.8 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Ribosomal_L50 PF10501.9 EDN04447.1 - 2.4e-30 104.9 0.1 4.4e-30 104.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal subunit 39S Thiolase_N PF00108.23 EDN04448.1 - 1.5e-70 237.5 0.1 2.5e-70 236.8 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN04448.1 - 8.7e-46 154.6 0.4 8.7e-46 154.6 0.4 2.1 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDN04448.1 - 0.0074 15.9 2.7 0.012 15.2 0.8 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain DAHP_synth_1 PF00793.20 EDN04450.1 - 6.4e-101 336.8 0.0 8.2e-101 336.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family COX14 PF14880.6 EDN04452.1 - 7e-05 22.6 0.0 7e-05 22.6 0.0 2.5 3 1 1 4 4 4 1 Cytochrome oxidase c assembly CCP_MauG PF03150.14 EDN04452.1 - 0.0063 17.2 0.4 0.013 16.2 0.1 1.6 1 1 1 2 2 2 1 Di-haem cytochrome c peroxidase p450 PF00067.22 EDN04455.1 - 3.7e-48 164.4 0.0 1.7e-47 162.3 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 TDH PF03347.13 EDN04455.1 - 0.029 13.9 0.0 0.067 12.7 0.0 1.6 2 0 0 2 2 2 0 Vibrio thermostable direct hemolysin Exo_endo_phos_2 PF14529.6 EDN04458.1 - 3.6e-06 26.8 0.2 8.8e-06 25.6 0.2 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase FKS1_dom1 PF14288.6 EDN04458.1 - 0.053 13.9 0.1 0.44 10.9 0.0 2.5 2 0 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 RNase_H PF00075.24 EDN04459.1 - 1.8e-05 25.0 0.1 2.2e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 RNase H Integrase_H2C2 PF17921.1 EDN04461.1 - 3.8e-20 71.7 1.8 4.1e-20 71.6 0.3 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EDN04461.1 - 0.00042 20.5 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger NCBP3 PF10309.9 EDN04461.1 - 0.13 12.1 0.5 0.31 10.9 0.5 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 RVT_1 PF00078.27 EDN04462.1 - 6.9e-27 94.4 0.0 1.3e-26 93.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN04462.1 - 0.063 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF3435 PF11917.8 EDN04463.1 - 1e-34 120.2 0.0 3.3e-34 118.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) HAUS-augmin3 PF14932.6 EDN04464.1 - 3.6e-05 23.5 1.3 4.5e-05 23.2 1.3 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 EDN04464.1 - 6.1e-05 23.2 0.7 7.7e-05 22.9 0.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus zf-C3HC4_3 PF13920.6 EDN04464.1 - 7.8e-05 22.5 10.2 0.00011 22.0 10.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DegS PF05384.11 EDN04464.1 - 0.00016 21.2 2.3 0.00021 20.8 2.3 1.1 1 0 0 1 1 1 1 Sensor protein DegS zf-C3HC4 PF00097.25 EDN04464.1 - 0.00032 20.5 8.2 0.00063 19.6 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4200 PF13863.6 EDN04464.1 - 0.0015 18.9 5.6 0.0022 18.4 5.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Troponin PF00992.20 EDN04464.1 - 0.0015 18.8 4.4 0.002 18.4 4.4 1.1 1 0 0 1 1 1 1 Troponin Lebercilin PF15619.6 EDN04464.1 - 0.0051 16.5 2.6 0.0063 16.2 2.6 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 EDN04464.1 - 0.0056 16.9 0.5 0.0076 16.4 0.5 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EDN04464.1 - 0.0062 17.0 1.8 0.0077 16.7 1.8 1.1 1 0 0 1 1 1 1 Fez1 DUF4407 PF14362.6 EDN04464.1 - 0.0077 15.6 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) zf-RING_5 PF14634.6 EDN04464.1 - 0.0078 16.1 8.2 0.014 15.4 8.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Interferon PF00143.19 EDN04464.1 - 0.01 16.0 0.1 0.013 15.7 0.1 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain zf-C3HC4_2 PF13923.6 EDN04464.1 - 0.01 15.7 8.9 0.022 14.6 8.9 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Macoilin PF09726.9 EDN04464.1 - 0.012 14.2 2.9 0.015 13.9 2.9 1.0 1 0 0 1 1 1 0 Macoilin family DivIC PF04977.15 EDN04464.1 - 0.013 15.2 2.1 0.021 14.6 2.1 1.4 1 0 0 1 1 1 0 Septum formation initiator GAS PF13851.6 EDN04464.1 - 0.014 14.7 2.0 0.02 14.3 2.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EDN04464.1 - 0.015 15.7 1.6 1.2 9.6 0.4 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 EDN04464.1 - 0.021 14.9 3.0 0.028 14.5 3.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF848 PF05852.11 EDN04464.1 - 0.03 14.5 1.1 0.04 14.0 1.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) bZIP_1 PF00170.21 EDN04464.1 - 0.033 14.3 3.8 0.1 12.7 3.8 1.8 1 1 0 1 1 1 0 bZIP transcription factor DUF4164 PF13747.6 EDN04464.1 - 0.045 14.0 5.0 0.066 13.5 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) CENP-Q PF13094.6 EDN04464.1 - 0.045 14.0 2.0 0.052 13.7 2.0 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF641 PF04859.12 EDN04464.1 - 0.062 13.6 1.2 0.082 13.2 1.2 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Exonuc_VII_L PF02601.15 EDN04464.1 - 0.062 12.9 0.2 0.075 12.6 0.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Metal_resist PF13801.6 EDN04464.1 - 0.063 13.5 2.3 0.086 13.0 2.3 1.1 1 0 0 1 1 1 0 Heavy-metal resistance DUF1192 PF06698.11 EDN04464.1 - 0.077 13.1 2.3 0.14 12.2 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Trimer_CC PF08954.11 EDN04464.1 - 0.078 12.5 5.7 0.15 11.7 5.7 1.4 1 0 0 1 1 1 0 Trimerisation motif TRAUB PF08164.12 EDN04464.1 - 0.098 13.2 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal BLOC1_2 PF10046.9 EDN04464.1 - 0.11 12.8 1.5 0.15 12.4 1.5 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2730 PF10805.8 EDN04464.1 - 0.12 12.5 0.8 0.21 11.7 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) TMF_TATA_bd PF12325.8 EDN04464.1 - 0.18 12.1 5.3 0.48 10.7 5.3 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding zf-RING_2 PF13639.6 EDN04464.1 - 2.2 8.7 13.1 3.8 7.9 13.1 1.4 1 0 0 1 1 1 0 Ring finger domain RNase_H PF00075.24 EDN04465.1 - 9.7e-13 48.5 0.0 2.2e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN04465.1 - 3.6e-05 23.6 0.0 6.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like RVT_1 PF00078.27 EDN04466.1 - 1.6e-37 129.1 0.0 3e-37 128.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN04466.1 - 6e-24 84.2 0.2 2e-23 82.5 0.2 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN04466.1 - 5.5e-12 46.1 0.0 1.4e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN04466.1 - 2.8e-05 23.9 0.5 0.00037 20.3 0.0 2.4 2 0 0 2 2 2 1 Reverse transcriptase-like Exo_endo_phos PF03372.23 EDN04466.1 - 0.00063 19.3 0.2 0.0023 17.5 0.2 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PuR_N PF09182.10 EDN04466.1 - 0.0007 19.5 0.1 0.0049 16.8 0.1 2.3 2 0 0 2 2 2 1 Bacterial purine repressor, N-terminal zf-CCHC PF00098.23 EDN04466.1 - 0.012 15.7 4.6 0.033 14.3 4.6 1.8 1 0 0 1 1 1 0 Zinc knuckle AAA_assoc PF14363.6 EDN04469.1 - 0.017 15.4 0.2 0.033 14.5 0.1 1.5 2 0 0 2 2 2 0 Domain associated at C-terminal with AAA Tegument_dsDNA PF12818.7 EDN04470.1 - 0.085 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein RVT_1 PF00078.27 EDN04471.1 - 1.1e-39 136.2 0.0 1.8e-39 135.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN04471.1 - 3.5e-24 84.9 0.0 9.2e-24 83.6 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN04471.1 - 6.4e-14 52.3 0.0 1.7e-13 51.0 0.0 1.8 1 0 0 1 1 1 1 RNase H Exo_endo_phos PF03372.23 EDN04471.1 - 1.2e-10 41.3 0.4 2.7e-10 40.2 0.4 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C2H2_4 PF13894.6 EDN04471.1 - 1.4 10.0 5.7 0.47 11.4 0.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN04471.1 - 1.6 9.3 5.9 0.35 11.4 0.1 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type HTH_Tnp_Tc5 PF03221.16 EDN04473.1 - 0.041 13.9 0.5 0.081 13.0 0.4 1.5 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain RVT_1 PF00078.27 EDN04478.1 - 1.8e-40 138.8 0.0 2.8e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN04478.1 - 4.4e-13 49.1 0.0 1.4e-12 47.5 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN04478.1 - 0.00025 20.6 0.1 0.00048 19.7 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Hexokinase_2 PF03727.16 EDN04479.1 - 1.5e-56 191.6 0.0 8.6e-54 182.5 0.0 2.5 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDN04479.1 - 2.7e-46 158.0 0.0 4.6e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 Hexokinase FSA_C PF10479.9 EDN04479.1 - 0.1 10.7 5.7 0.14 10.3 5.7 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 EDN04479.1 - 0.12 12.4 18.2 0.27 11.2 18.2 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 EDN04479.1 - 4.1 5.3 5.2 5.8 4.8 5.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NDT80_PhoG PF05224.12 EDN04481.1 - 6.2e-37 127.6 0.4 1.4e-36 126.5 0.0 1.9 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family Pex14_N PF04695.13 EDN04481.1 - 7.2 7.2 15.7 26 5.4 0.6 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_hydro_3 PF00933.21 EDN04485.1 - 1.7e-67 228.1 0.0 2.2e-67 227.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EDN04485.1 - 2.9e-05 24.3 0.0 0.00012 22.3 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Glucosamine_iso PF01182.20 EDN04486.1 - 3.3e-15 56.6 0.0 6.4e-15 55.6 0.0 1.4 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Aldedh PF00171.22 EDN04487.1 - 1.1e-156 522.0 0.1 1.3e-156 521.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family p450 PF00067.22 EDN04488.1 - 1.1e-50 172.7 0.0 5.7e-49 167.1 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 GMC_oxred_N PF00732.19 EDN04490.1 - 6.2e-49 167.0 0.0 7.9e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN04490.1 - 1.3e-38 132.8 0.1 1.8e-38 132.3 0.1 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EDN04490.1 - 9.1e-06 25.0 0.0 1.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EDN04490.1 - 0.00011 22.4 0.1 0.00031 20.9 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EDN04490.1 - 0.00031 19.9 0.0 0.14 11.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EDN04490.1 - 0.00066 19.4 0.6 0.0039 16.8 0.1 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN04490.1 - 0.0024 17.2 0.0 0.0078 15.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDN04490.1 - 0.007 15.3 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.17 EDN04490.1 - 0.0081 15.4 0.1 0.053 12.7 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EDN04490.1 - 0.026 15.1 0.2 1.9 9.1 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDN04490.1 - 0.082 12.2 0.4 0.59 9.4 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDN04490.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Hydrophobin PF01185.18 EDN04491.1 - 2.6e-06 28.0 7.2 1.7e-05 25.4 7.2 2.1 1 1 0 1 1 1 1 Fungal hydrophobin DUF3782 PF12644.7 EDN04492.1 - 0.098 12.8 0.4 0.14 12.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) Amidohydro_1 PF01979.20 EDN04493.1 - 2.1e-10 40.5 0.1 3.7e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EDN04493.1 - 2.6e-08 33.8 0.2 4e-08 33.2 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase family MFS_1 PF07690.16 EDN04495.1 - 6.9e-17 61.4 30.4 9.2e-17 61.0 30.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDN04495.1 - 3e-09 36.8 7.3 3e-09 36.8 7.3 2.9 2 2 1 3 3 3 1 Ion channel regulatory protein UNC-93 GWT1 PF06423.12 EDN04495.1 - 0.0046 17.1 2.0 0.37 10.9 0.1 3.2 3 1 0 3 3 3 2 GWT1 Rick_17kDa_Anti PF05433.15 EDN04495.1 - 1.5 8.7 0.0 1.5 8.7 0.0 3.4 3 0 0 3 3 3 0 Glycine zipper 2TM domain Fungal_trans PF04082.18 EDN04496.1 - 8.3e-31 107.0 1.3 8.3e-31 107.0 1.3 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Secretin_N_2 PF07655.13 EDN04496.1 - 3.4 8.3 12.2 0.2 12.2 3.2 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain FAD_binding_3 PF01494.19 EDN04498.1 - 1e-14 54.6 0.1 2.4e-14 53.3 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EDN04498.1 - 0.0072 15.4 1.9 1.3 8.0 0.0 2.6 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EDN04498.1 - 0.045 13.0 0.1 0.24 10.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDN04498.1 - 0.16 11.5 0.3 0.48 9.9 0.1 1.7 2 1 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDN04498.1 - 0.44 10.8 0.0 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Fungal_TACC PF12709.7 EDN04499.1 - 9.7e-09 35.6 3.1 9.7e-09 35.6 3.1 5.0 5 0 0 5 5 5 2 Fungal Transforming acidic coiled-coil (TACC) proteins FPP PF05911.11 EDN04499.1 - 0.00043 18.6 13.0 0.00043 18.6 13.0 2.8 1 1 0 2 2 2 1 Filament-like plant protein, long coiled-coil Pox_A_type_inc PF04508.12 EDN04499.1 - 0.93 9.5 0.0 0.93 9.5 0.0 4.3 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF2244 PF10003.9 EDN04500.1 - 0.22 11.2 0.0 0.22 11.2 0.0 2.8 3 0 0 3 3 3 0 Integral membrane protein (DUF2244) DbpA PF03880.15 EDN04501.1 - 0.013 15.5 0.1 0.027 14.5 0.1 1.5 1 0 0 1 1 1 0 DbpA RNA binding domain RRM_1 PF00076.22 EDN04501.1 - 0.15 11.9 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FSAP_sig_propep PF03032.15 EDN04502.1 - 8.6 6.5 9.1 28 4.8 9.1 1.9 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide Prok_Ub PF14454.6 EDN04503.1 - 0.081 12.6 0.1 7.3 6.3 0.0 3.1 2 1 1 3 3 3 0 Prokaryotic Ubiquitin IBN_N PF03810.19 EDN04505.1 - 7e-15 54.7 0.0 7.2e-13 48.3 0.0 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 EDN04505.1 - 8.9e-08 31.4 0.0 2.2e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Cse1 Xpo1 PF08389.12 EDN04505.1 - 0.0054 16.8 0.4 0.14 12.2 0.0 3.5 3 0 0 3 3 3 1 Exportin 1-like protein RTP1_C1 PF10363.9 EDN04505.1 - 0.015 15.5 0.4 0.2 11.8 0.2 3.1 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EDN04505.1 - 0.016 15.6 2.5 1.9 8.9 0.0 3.6 3 1 2 5 5 5 0 HEAT repeats CAS_CSE1 PF03378.15 EDN04505.1 - 0.023 13.2 0.1 0.17 10.4 0.0 2.5 3 0 0 3 3 3 0 CAS/CSE protein, C-terminus GRIP PF01465.20 EDN04505.1 - 0.062 13.2 0.5 0.87 9.5 0.0 3.2 3 0 0 3 3 3 0 GRIP domain HEAT_EZ PF13513.6 EDN04505.1 - 2.3 8.8 11.3 46 4.7 0.7 6.1 6 1 1 7 7 7 0 HEAT-like repeat DSHCT PF08148.12 EDN04506.1 - 4.1e-52 176.1 0.3 1.1e-51 174.8 0.3 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EDN04506.1 - 6.3e-38 129.6 0.0 1.4e-37 128.5 0.0 1.6 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 EDN04506.1 - 6.2e-18 65.2 0.0 1.3e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 EDN04506.1 - 9.3e-16 58.5 0.1 2.6e-15 57.1 0.1 1.8 1 1 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.31 EDN04506.1 - 3.1e-06 27.5 0.0 1.5e-05 25.3 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN04506.1 - 1.2e-05 25.4 0.0 3e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Choline_transpo PF04515.12 EDN04507.1 - 2.4e-63 214.3 14.4 2.4e-63 214.3 14.4 2.0 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF2415 PF10313.9 EDN04508.1 - 2.7e-13 49.6 0.0 6.3e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) HSP70 PF00012.20 EDN04510.1 - 4.6e-266 883.8 14.2 5.4e-266 883.5 14.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDN04510.1 - 2.2e-14 53.0 8.1 3.9e-13 48.9 1.8 2.7 3 0 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.16 EDN04510.1 - 6.5e-05 22.7 0.1 0.00016 21.4 0.1 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 EDN04510.1 - 0.02 14.1 4.6 0.046 13.0 0.1 2.9 2 1 1 3 3 3 0 StbA protein Big_3_4 PF13754.6 EDN04510.1 - 0.14 11.9 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function FtsA PF14450.6 EDN04510.1 - 1.8 9.1 12.2 1.2 9.6 1.2 4.0 3 3 0 3 3 3 0 Cell division protein FtsA SMBP PF16785.5 EDN04510.1 - 2.5 8.3 10.1 0.76 10.0 6.1 2.2 2 0 0 2 2 2 0 Small metal-binding protein Tom22 PF04281.13 EDN04510.1 - 8.1 6.2 10.0 1.5 8.6 5.8 2.0 1 1 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Macro_2 PF14519.6 EDN04511.1 - 0.024 14.0 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Macro-like domain Methyltransf_16 PF10294.9 EDN04512.1 - 1.5e-11 44.3 0.0 7.1e-07 29.1 0.0 2.8 3 0 0 3 3 3 2 Lysine methyltransferase AMP-binding PF00501.28 EDN04514.1 - 3.7e-91 305.8 0.0 6.1e-91 305.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NDT80_PhoG PF05224.12 EDN04515.1 - 2.3e-41 142.1 0.0 4.5e-41 141.1 0.0 1.5 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family YfhO PF09586.10 EDN04515.1 - 0.036 12.3 0.8 0.051 11.8 0.8 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO eIF3g PF12353.8 EDN04517.1 - 2.6e-44 150.6 1.3 2.6e-44 150.6 1.3 1.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EDN04517.1 - 3.2e-16 58.9 0.0 5.2e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN04517.1 - 0.0079 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif zf-CCCH_7 PF18586.1 EDN04517.1 - 0.04 14.3 0.3 0.094 13.1 0.3 1.5 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 RRM_3 PF08777.11 EDN04517.1 - 0.047 13.7 1.6 4.4 7.4 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif ribosomal_L24 PF17136.4 EDN04517.1 - 0.93 9.9 5.7 0.27 11.7 0.7 2.6 2 1 1 3 3 3 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 Involucrin_N PF10583.9 EDN04518.1 - 0.034 14.7 0.1 8 7.1 0.0 2.5 2 0 0 2 2 2 0 Involucrin of squamous epithelia N-terminus DUF1737 PF08410.10 EDN04518.1 - 0.064 13.1 0.0 2.5 8.0 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1737) Hexose_dehydrat PF03559.14 EDN04518.1 - 0.13 11.6 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase TIM21 PF08294.11 EDN04519.1 - 1.5e-43 148.1 0.0 2e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EDN04519.1 - 1.8e-06 27.6 0.0 5.1e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 B12D PF06522.11 EDN04519.1 - 0.0028 17.4 0.4 0.014 15.2 0.0 2.2 2 0 0 2 2 2 1 NADH-ubiquinone reductase complex 1 MLRQ subunit CIA30 PF08547.12 EDN04519.1 - 0.086 12.9 0.0 0.23 11.4 0.0 1.7 2 0 0 2 2 2 0 Complex I intermediate-associated protein 30 (CIA30) ArfGap PF01412.18 EDN04520.1 - 5e-34 116.9 0.2 8.3e-34 116.2 0.2 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GATA PF00320.27 EDN04520.1 - 0.035 13.7 0.8 0.066 12.8 0.8 1.5 1 0 0 1 1 1 0 GATA zinc finger IF2_N PF04760.15 EDN04520.1 - 0.13 12.0 0.1 7.6 6.4 0.0 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region Pterin_bind PF00809.22 EDN04521.1 - 2.3e-76 256.7 0.0 8e-76 254.9 0.0 1.8 1 1 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EDN04521.1 - 8.4e-36 122.9 0.0 1.7e-35 121.9 0.0 1.5 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Aminotran_5 PF00266.19 EDN04522.1 - 3e-39 135.0 0.0 1.7e-38 132.6 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V EAL PF00563.20 EDN04522.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 EAL domain NMO PF03060.15 EDN04524.1 - 5.8e-55 187.0 0.8 7.9e-55 186.5 0.8 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDN04524.1 - 8.3e-11 41.5 0.6 4.7e-10 39.0 0.6 1.9 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EDN04524.1 - 1.3e-07 31.0 0.9 2.3e-07 30.2 0.9 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 EDN04524.1 - 3e-05 23.4 0.3 4.6e-05 22.8 0.3 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EDN04524.1 - 0.00025 20.3 0.9 0.00042 19.6 0.9 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase DUF4376 PF14301.6 EDN04525.1 - 0.026 14.9 0.6 0.048 14.0 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4376) Neuroparsin PF07327.11 EDN04525.1 - 0.055 13.9 1.2 2.5 8.6 2.1 2.3 2 1 0 2 2 2 0 Neuroparsin PWI PF01480.17 EDN04526.1 - 7.4e-15 55.0 1.4 1.9e-14 53.7 1.4 1.8 1 0 0 1 1 1 1 PWI domain Chromo PF00385.24 EDN04526.1 - 2.5e-07 30.5 0.0 6.8e-07 29.1 0.0 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RRM_1 PF00076.22 EDN04526.1 - 0.0047 16.7 0.0 0.0098 15.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Retrotrans_gag PF03732.17 EDN04527.1 - 0.006 16.8 0.7 0.015 15.5 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon gag protein RT_RNaseH_2 PF17919.1 EDN04528.1 - 2.3e-22 78.9 0.0 4.9e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN04528.1 - 8.7e-22 77.7 0.0 1.6e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 EDN04528.1 - 9.3e-14 51.6 0.0 1.9e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase YscO PF07321.12 EDN04530.1 - 0.023 14.7 3.1 0.046 13.7 1.0 2.0 2 0 0 2 2 2 0 Type III secretion protein YscO DUF2783 PF10932.8 EDN04530.1 - 0.035 13.8 0.1 0.077 12.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) DUF1664 PF07889.12 EDN04530.1 - 0.066 13.2 1.5 0.48 10.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Interferon PF00143.19 EDN04530.1 - 0.14 12.3 4.7 0.25 11.5 0.8 2.1 2 0 0 2 2 2 0 Interferon alpha/beta domain Spc7 PF08317.11 EDN04530.1 - 0.51 9.2 5.5 0.31 9.9 0.8 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Tup_N PF08581.10 EDN04530.1 - 0.56 10.5 6.2 7.7 6.9 0.4 2.5 2 0 0 2 2 2 0 Tup N-terminal Tropomyosin_1 PF12718.7 EDN04530.1 - 0.68 10.1 5.5 7.6 6.7 0.3 2.1 2 0 0 2 2 2 0 Tropomyosin like SlyX PF04102.12 EDN04530.1 - 1.5 9.5 7.5 11 6.7 0.9 2.7 2 1 0 2 2 2 0 SlyX MerR-DNA-bind PF09278.11 EDN04530.1 - 2 9.0 7.4 13 6.4 0.3 3.0 2 1 1 3 3 3 0 MerR, DNA binding F-box PF00646.33 EDN04531.1 - 0.00014 21.7 0.0 0.00032 20.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN04531.1 - 0.0024 17.7 0.1 0.0068 16.3 0.1 1.9 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EDN04531.1 - 0.027 14.8 0.0 0.21 11.9 0.0 2.4 2 0 0 2 2 2 0 PRANC domain DUF390 PF04094.14 EDN04532.1 - 0.0018 16.6 5.1 0.0034 15.7 5.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF390) Rootletin PF15035.6 EDN04532.1 - 0.0082 16.2 9.6 0.0082 16.2 9.6 1.8 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion HAUS-augmin3 PF14932.6 EDN04532.1 - 0.026 14.1 7.1 0.13 11.8 7.5 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Synaptobrevin PF00957.21 EDN04532.1 - 0.03 14.1 3.3 0.21 11.4 3.9 2.1 2 0 0 2 2 2 0 Synaptobrevin UPF0449 PF15136.6 EDN04532.1 - 0.083 13.4 4.5 0.38 11.2 4.5 2.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 GldM_N PF12081.8 EDN04532.1 - 0.12 12.4 0.4 0.22 11.6 0.4 1.3 1 0 0 1 1 1 0 GldM N-terminal domain Ax_dynein_light PF10211.9 EDN04532.1 - 0.29 11.1 13.2 0.67 9.9 13.2 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain Pinin_SDK_memA PF04696.13 EDN04532.1 - 1.2 9.2 21.0 3.2 7.8 21.0 1.6 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region GAS PF13851.6 EDN04532.1 - 2 7.7 13.9 0.98 8.7 11.0 1.8 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding PIEZO PF15917.5 EDN04532.1 - 3.5 7.0 7.5 7.8 5.9 7.5 1.5 1 0 0 1 1 1 0 Piezo HAUS6_N PF14661.6 EDN04532.1 - 5.6 6.5 10.3 10 5.6 10.3 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus CENP-Q PF13094.6 EDN04532.1 - 5.7 7.1 17.5 6.2 7.0 12.9 2.5 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4470 PF14737.6 EDN04533.1 - 0.012 15.8 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) APH PF01636.23 EDN04533.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PGI PF00342.19 EDN04536.1 - 3.2e-239 794.5 0.7 3.6e-239 794.3 0.7 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase AP3D1 PF06375.11 EDN04537.1 - 0.011 16.0 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Ribosomal_S21 PF01165.20 EDN04538.1 - 6.1e-11 41.9 3.0 1.1e-10 41.1 3.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 Rhodanese PF00581.20 EDN04539.1 - 3.8e-09 37.0 0.0 5.1e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_28 PF02636.17 EDN04540.1 - 1.8e-88 296.5 0.0 2.3e-88 296.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase SH3-RhoG_link PF16609.5 EDN04542.1 - 0.00039 20.2 0.2 0.0008 19.2 0.2 1.5 1 0 0 1 1 1 1 SH3-RhoGEF linking unstructured region RRM_4 PF10598.9 EDN04542.1 - 0.085 13.2 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif of the spliceosomal PrP8 USP7_ICP0_bdg PF12436.8 EDN04542.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 MIF4G PF02854.19 EDN04543.1 - 9.8e-50 169.1 0.0 9.8e-50 169.1 0.0 1.6 2 0 0 2 2 2 1 MIF4G domain eIF_4G1 PF12152.8 EDN04543.1 - 1.8e-24 85.7 2.7 5.6e-24 84.1 2.7 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Actin PF00022.19 EDN04544.1 - 1.6e-151 504.5 0.0 5.9e-151 502.7 0.0 1.7 1 1 0 1 1 1 1 Actin Fes1 PF08609.10 EDN04545.1 - 9.6e-29 100.1 2.2 1.5e-28 99.5 1.0 1.9 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.6 EDN04545.1 - 0.00021 21.6 0.0 0.00064 20.1 0.0 1.9 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 EDN04545.1 - 0.00048 20.6 0.1 0.002 18.6 0.1 2.0 1 1 0 1 1 1 1 HEAT-like repeat HEAT PF02985.22 EDN04545.1 - 0.0011 19.0 0.0 0.047 14.0 0.0 3.0 3 0 0 3 3 3 1 HEAT repeat RICTOR_V PF14668.6 EDN04545.1 - 0.014 15.6 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 SIL1 PF16782.5 EDN04545.1 - 0.075 12.2 0.0 0.97 8.6 0.0 2.1 1 1 1 2 2 2 0 Nucleotide exchange factor SIL1 UPF0220 PF05255.11 EDN04546.1 - 1.9e-69 232.4 3.3 2.2e-69 232.3 3.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Sld7_C PF18596.1 EDN04547.1 - 1.6e-12 47.4 0.0 4.8e-12 45.8 0.0 1.8 1 1 0 1 1 1 1 Sld7 C-terminal domain Vps55 PF04133.14 EDN04548.1 - 2.9e-43 146.5 8.6 3.3e-43 146.3 8.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4231 PF14015.6 EDN04548.1 - 0.56 10.7 0.0 0.56 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) SecD-TM1 PF13721.6 EDN04548.1 - 0.73 10.3 3.0 6.5 7.3 0.4 2.5 2 1 1 3 3 3 0 SecD export protein N-terminal TM region Proteasome PF00227.26 EDN04549.1 - 1.2e-49 168.4 0.1 1.5e-49 168.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDN04549.1 - 3.1e-12 45.9 0.3 5e-12 45.3 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Lysine_decarbox PF03641.14 EDN04550.1 - 5.7e-27 94.4 0.0 8.8e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EDN04550.1 - 0.02 14.5 1.2 0.062 12.9 0.2 2.1 2 0 0 2 2 2 0 SLOG cluster4 family Med6 PF04934.14 EDN04551.1 - 1.5e-39 134.8 0.0 2.4e-39 134.2 0.0 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component RdRP PF05183.12 EDN04552.1 - 7.1e-162 540.1 0.0 1.4e-116 390.5 0.0 2.3 1 1 1 2 2 2 2 RNA dependent RNA polymerase Chalcone_2 PF16035.5 EDN04553.1 - 0.16 11.8 0.0 0.16 11.7 0.0 1.0 1 0 0 1 1 1 0 Chalcone isomerase like Chorismate_bind PF00425.18 EDN04554.1 - 8.2e-67 225.5 0.1 2.7e-65 220.5 0.0 2.4 2 1 0 2 2 2 1 chorismate binding enzyme GATase PF00117.28 EDN04554.1 - 7.1e-31 107.5 0.0 1.2e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EDN04554.1 - 8.9e-10 38.9 0.0 2e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EDN04554.1 - 4.1e-07 30.0 0.1 2e-06 27.7 0.1 2.2 2 1 0 2 2 2 1 Peptidase C26 DUF3684 PF12449.8 EDN04555.1 - 0 1448.3 0.1 0 1448.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EDN04555.1 - 0.00094 19.0 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SAM_PNT PF02198.16 EDN04555.1 - 0.077 13.0 0.2 27 4.8 0.1 3.5 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain TRAPPC9-Trs120 PF08626.11 EDN04556.1 - 0 1421.2 0.0 0 1421.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF4354 PF14263.6 EDN04556.1 - 0.2 11.5 0.1 1 9.2 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4354) Abhydrolase_1 PF00561.20 EDN04557.1 - 1.1e-11 44.9 0.1 3.5e-11 43.3 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN04557.1 - 5.3e-08 32.4 0.0 2.7e-07 30.1 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Secretin_N_2 PF07655.13 EDN04558.1 - 7.4 7.2 11.9 0.96 10.0 1.9 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Complex1_LYR_2 PF13233.6 EDN04559.1 - 0.00026 21.6 0.2 0.00036 21.2 0.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EDN04559.1 - 0.0017 18.4 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) RNA_pol_L_2 PF13656.6 EDN04560.1 - 1.5e-32 111.2 0.0 2e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDN04560.1 - 4.5e-13 48.4 0.0 6.5e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Lactamase_B_6 PF16661.5 EDN04560.1 - 0.18 11.2 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Peptidase_M22 PF00814.25 EDN04562.1 - 9.6e-85 284.6 0.0 1.2e-84 284.2 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EDN04562.1 - 0.045 13.4 0.0 0.92 9.1 0.0 2.1 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus SET PF00856.28 EDN04563.1 - 1.1e-19 71.5 0.0 2.3e-19 70.4 0.0 1.6 1 1 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 EDN04563.1 - 4e-13 50.2 0.0 1.5e-12 48.3 0.0 1.9 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding EPL1 PF10513.9 EDN04564.1 - 1.3e-19 71.1 0.4 1.3e-19 71.1 0.4 2.6 2 1 0 2 2 2 1 Enhancer of polycomb-like DnaT PF17948.1 EDN04564.1 - 0.31 10.8 0.1 0.31 10.8 0.1 3.0 3 0 0 3 3 3 0 DnaT DNA-binding domain Latarcin PF10279.9 EDN04564.1 - 0.59 10.6 4.5 1.3 9.4 2.2 2.5 2 0 0 2 2 2 0 Latarcin precursor EF-hand_1 PF00036.32 EDN04565.1 - 1.7e-19 67.8 12.0 2.4e-08 32.9 0.6 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EDN04565.1 - 3e-15 56.4 5.0 1.7e-13 50.8 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDN04565.1 - 2.1e-14 52.1 4.2 3.9e-05 23.2 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EDN04565.1 - 1.2e-12 46.7 7.6 2.8e-07 29.7 0.4 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EDN04565.1 - 5.3e-10 39.0 9.0 0.00014 21.7 0.9 3.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EDN04565.1 - 0.00022 21.1 5.4 0.048 13.6 0.2 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDN04565.1 - 0.00077 19.8 0.1 0.0029 17.9 0.0 2.0 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EDN04565.1 - 0.027 14.8 0.1 0.4 11.0 0.1 2.5 2 1 1 3 3 3 0 EF-hand domain Methyltransf_23 PF13489.6 EDN04566.1 - 1.6e-09 37.8 0.0 1.1e-06 28.5 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EDN04566.1 - 0.0092 15.8 0.7 0.3 10.9 0.7 2.2 1 1 0 1 1 1 1 Methyltransferase domain CUTL PF16557.5 EDN04566.1 - 0.035 14.3 0.5 4.2 7.6 0.1 2.6 3 0 0 3 3 3 0 CUT1-like DNA-binding domain of SATB Methyltransf_25 PF13649.6 EDN04566.1 - 0.04 14.6 2.4 1.6 9.5 1.7 2.7 2 1 0 2 2 2 0 Methyltransferase domain Ribosomal_S9 PF00380.19 EDN04569.1 - 9.1e-40 135.9 0.1 1.8e-39 135.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 PDEase_I_N PF08499.12 EDN04569.1 - 0.006 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal EF1G PF00647.19 EDN04570.1 - 2e-47 159.7 0.1 3.7e-47 158.8 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EDN04570.1 - 1.2e-13 51.1 0.1 3.9e-13 49.4 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDN04570.1 - 4.5e-10 39.7 0.0 8.9e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDN04570.1 - 4.8e-08 32.9 0.1 1.2e-07 31.6 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDN04570.1 - 1.5e-05 25.3 0.0 3.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDN04570.1 - 2.1e-05 24.6 0.1 6.9e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain RRP36 PF06102.12 EDN04571.1 - 1e-44 152.5 20.6 1e-44 152.5 20.6 2.1 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 NIF PF03031.18 EDN04572.1 - 5.6e-22 78.2 0.2 2.5e-14 53.3 0.0 2.2 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase AMPKBI PF04739.15 EDN04574.1 - 1.1e-22 80.1 0.9 1.1e-22 80.1 0.9 2.3 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EDN04574.1 - 1.2e-14 54.2 0.2 7e-13 48.6 0.2 2.5 1 1 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase PPP4R2 PF09184.11 EDN04575.1 - 0.69 9.4 15.2 0.92 9.0 15.2 1.1 1 0 0 1 1 1 0 PPP4R2 ABC1 PF03109.16 EDN04576.1 - 3.9e-34 117.4 0.0 9.3e-34 116.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EDN04576.1 - 0.039 13.3 0.0 1.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain UreF PF01730.16 EDN04577.1 - 1.3e-21 77.5 0.2 2.1e-21 76.9 0.2 1.3 1 0 0 1 1 1 1 UreF Sugarporin_N PF11471.8 EDN04577.1 - 0.0015 18.4 0.4 0.0074 16.2 0.4 2.2 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension Pox_A_type_inc PF04508.12 EDN04577.1 - 0.097 12.6 0.3 0.2 11.6 0.3 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat G10 PF01125.17 EDN04577.1 - 0.15 11.8 0.0 0.94 9.2 0.0 2.2 2 1 0 2 2 2 0 G10 protein BRE1 PF08647.11 EDN04578.1 - 3.7e-28 97.4 12.7 3.7e-28 97.4 12.7 6.7 5 2 1 7 7 7 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EDN04578.1 - 4.2e-10 39.3 7.9 6.9e-10 38.6 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN04578.1 - 2.9e-09 36.6 8.5 5.1e-09 35.8 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN04578.1 - 9.8e-08 31.7 10.8 1.8e-07 30.9 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN04578.1 - 1.1e-07 31.7 6.4 2.2e-07 30.8 6.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDN04578.1 - 1.1e-07 32.0 9.1 2.1e-07 31.2 9.1 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EDN04578.1 - 2.2e-07 30.6 8.5 4e-07 29.8 8.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDN04578.1 - 2.3e-06 27.5 11.2 3.9e-06 26.7 11.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain KxDL PF10241.9 EDN04578.1 - 0.0018 18.5 17.1 0.0034 17.6 3.6 6.1 5 2 0 6 6 6 2 Uncharacterized conserved protein zf-C3HC4_4 PF15227.6 EDN04578.1 - 0.0018 18.4 7.0 0.0033 17.5 7.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDN04578.1 - 0.0023 18.2 6.2 0.0065 16.7 5.5 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain DUF1272 PF06906.11 EDN04578.1 - 0.016 15.3 5.5 0.036 14.1 5.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_10 PF16685.5 EDN04578.1 - 0.031 14.4 7.1 0.079 13.1 7.1 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EDN04578.1 - 0.072 12.9 7.8 0.56 10.1 8.5 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 EDN04578.1 - 0.42 10.8 3.9 1.1 9.4 3.9 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-Nse PF11789.8 EDN04578.1 - 0.44 10.4 5.7 1.1 9.1 5.7 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF1192 PF06698.11 EDN04578.1 - 0.62 10.2 0.0 0.62 10.2 0.0 5.6 7 1 0 7 7 5 0 Protein of unknown function (DUF1192) zf-RING_6 PF14835.6 EDN04578.1 - 1.1 9.2 4.0 2.3 8.1 4.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DZR PF12773.7 EDN04578.1 - 1.1 9.3 6.3 2.3 8.3 6.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 EDN04578.1 - 2.1 8.6 13.1 1.3 9.2 6.7 2.5 1 1 1 2 2 2 0 FYVE zinc finger Myb_DNA-bind_7 PF15963.5 EDN04579.1 - 1.6e-28 98.5 0.7 3.9e-28 97.2 0.2 2.0 1 1 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EDN04579.1 - 0.00038 20.6 0.0 0.00094 19.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain MMM1 PF10296.9 EDN04580.1 - 6.9e-112 373.8 0.1 2e-110 368.9 0.1 2.2 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 SARAF PF06682.12 EDN04580.1 - 3.9e-62 210.8 0.1 3.9e-62 210.8 0.1 2.0 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Podoplanin PF05808.11 EDN04580.1 - 2.4 8.2 4.8 4.8 7.3 4.8 1.4 1 0 0 1 1 1 0 Podoplanin ARD PF03079.14 EDN04581.1 - 4.3e-47 160.2 0.0 5.3e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EDN04581.1 - 5.5e-11 42.0 0.1 8.2e-11 41.5 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EDN04581.1 - 3.8e-06 26.8 0.0 5.5e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EDN04581.1 - 0.00026 20.6 0.0 0.00036 20.2 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EDN04581.1 - 0.001 18.7 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 EDN04581.1 - 0.051 13.3 0.0 0.065 12.9 0.0 1.1 1 0 0 1 1 1 0 Cupin GIDA PF01134.22 EDN04582.1 - 4.1e-154 513.4 0.0 5e-154 513.1 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EDN04582.1 - 1.1e-66 225.0 0.0 1.5e-66 224.6 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 EDN04582.1 - 2.4e-06 27.0 0.2 4.3e-06 26.2 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDN04582.1 - 3.2e-05 23.5 2.7 5.7e-05 22.7 2.7 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EDN04582.1 - 0.0019 17.6 0.5 0.0033 16.8 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EDN04582.1 - 0.0065 15.6 2.9 0.0065 15.6 2.9 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EDN04582.1 - 0.054 14.1 0.2 0.15 12.6 0.2 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDN04582.1 - 0.06 12.0 0.8 0.54 8.9 0.6 2.1 2 0 0 2 2 2 0 HI0933-like protein tRNA-synt_1c PF00749.21 EDN04583.1 - 1.2e-97 326.6 0.0 1.4e-97 326.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDN04583.1 - 6.3e-30 104.3 0.0 1.4e-29 103.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Sec1 PF00995.23 EDN04584.1 - 1.7e-136 456.8 0.1 2e-136 456.6 0.1 1.0 1 0 0 1 1 1 1 Sec1 family Glyco_tran_WecB PF03808.13 EDN04584.1 - 0.07 13.1 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family L27 PF02828.16 EDN04584.1 - 0.087 12.6 0.3 0.25 11.1 0.3 1.8 1 1 0 1 1 1 0 L27 domain adh_short PF00106.25 EDN04585.1 - 3.5e-31 108.2 0.0 5.1e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN04585.1 - 6.1e-23 81.6 0.0 8.3e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN04585.1 - 4.5e-12 46.3 0.0 6.4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDN04585.1 - 7.9e-08 32.0 0.0 1.9e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDN04585.1 - 4.3e-05 23.1 0.0 5.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDN04585.1 - 0.00051 19.3 0.0 0.00064 18.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EDN04585.1 - 0.0027 16.9 0.0 0.007 15.5 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EDN04585.1 - 0.0067 15.5 0.1 0.009 15.0 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EDN04585.1 - 0.055 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family DUF4801 PF16059.5 EDN04585.1 - 0.13 12.3 0.6 0.31 11.0 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4801) HTH_Tnp_Tc5 PF03221.16 EDN04587.1 - 9.7e-14 51.2 0.1 2.2e-13 50.0 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN04587.1 - 0.0016 18.2 0.1 0.0031 17.2 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain UPF0565 PF10561.9 EDN04587.1 - 0.011 14.9 1.0 0.018 14.3 1.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Tyr-DNA_phospho PF06087.12 EDN04588.1 - 4.7e-47 160.9 0.0 6.3e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Peptidase_C80 PF11713.8 EDN04588.1 - 0.13 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase C80 family Tyr-DNA_phospho PF06087.12 EDN04589.1 - 2e-09 36.9 0.0 5.7e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase ABC2_membrane PF01061.24 EDN04590.1 - 1.6e-83 279.2 64.6 3.2e-42 144.3 20.7 2.5 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EDN04590.1 - 2.7e-38 131.6 0.8 8.9e-20 71.6 0.0 2.7 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EDN04590.1 - 2.3e-29 101.1 3.6 2.6e-26 91.3 0.0 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EDN04590.1 - 1.6e-13 51.1 0.6 5e-13 49.5 0.1 2.2 2 0 0 2 2 1 1 ABC-transporter N-terminal AAA_18 PF13238.6 EDN04590.1 - 1.7e-07 31.8 0.1 0.00015 22.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EDN04590.1 - 2.1e-07 31.5 0.0 0.00011 22.6 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EDN04590.1 - 1.1e-06 28.7 0.6 0.0035 17.2 0.1 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EDN04590.1 - 1.5e-06 27.6 13.1 1.5e-06 27.6 13.1 3.4 2 2 1 3 3 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EDN04590.1 - 6.3e-06 26.2 0.2 0.00023 21.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EDN04590.1 - 1.1e-05 25.6 0.0 0.018 15.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDN04590.1 - 0.0002 21.7 0.2 0.021 15.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain cobW PF02492.19 EDN04590.1 - 0.00036 20.2 0.2 0.022 14.3 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EDN04590.1 - 0.00081 19.3 0.3 0.15 12.0 0.2 2.5 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 EDN04590.1 - 0.00082 19.0 0.2 0.37 10.3 0.1 2.9 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EDN04590.1 - 0.0019 17.9 0.0 0.3 10.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EDN04590.1 - 0.0022 18.4 0.1 5.2 7.5 0.1 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EDN04590.1 - 0.0028 17.0 0.1 0.55 9.5 0.0 2.4 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_28 PF13521.6 EDN04590.1 - 0.004 17.4 1.1 0.014 15.6 0.1 2.4 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.6 EDN04590.1 - 0.0043 17.5 0.0 0.54 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EDN04590.1 - 0.0044 17.1 0.1 0.39 10.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 EDN04590.1 - 0.0045 16.4 0.2 0.16 11.4 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN04590.1 - 0.0087 15.8 4.2 0.068 12.9 0.3 3.3 4 0 0 4 4 4 1 P-loop containing region of AAA domain NB-ARC PF00931.22 EDN04590.1 - 0.0093 15.2 0.3 1 8.5 0.1 2.4 2 0 0 2 2 2 1 NB-ARC domain TsaE PF02367.17 EDN04590.1 - 0.012 15.6 0.1 1.3 9.1 0.2 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDN04590.1 - 0.03 14.1 0.5 2.2 8.0 0.3 2.4 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 EDN04590.1 - 0.042 13.1 0.1 0.49 9.6 0.1 2.4 2 0 0 2 2 2 0 Septin Pox_A32 PF04665.12 EDN04590.1 - 0.062 12.7 0.4 0.92 8.9 0.1 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_19 PF13245.6 EDN04590.1 - 0.082 13.2 0.6 6.3 7.1 0.3 2.5 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EDN04590.1 - 0.13 12.1 0.1 19 5.1 0.0 2.7 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 EDN04590.1 - 0.14 11.5 1.7 0.8 9.0 0.4 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 EDN04590.1 - 0.19 10.7 0.4 0.46 9.5 0.1 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_15 PF13175.6 EDN04590.1 - 0.25 11.0 2.6 2.5 7.7 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain Gti1_Pac2 PF09729.9 EDN04591.1 - 5.1e-64 215.7 0.1 1.4e-63 214.3 0.0 1.7 2 1 0 2 2 2 1 Gti1/Pac2 family MBOAT PF03062.19 EDN04600.1 - 9.2e-38 130.5 4.6 1.2e-37 130.1 4.6 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family zf-Di19 PF05605.12 EDN04605.1 - 0.00071 19.8 6.0 0.027 14.7 3.2 2.7 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EDN04605.1 - 0.0021 18.4 11.7 0.0034 17.7 4.5 3.8 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN04605.1 - 0.86 10.6 17.9 0.3 12.0 3.7 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-BED PF02892.15 EDN04605.1 - 1.6 8.8 10.6 0.32 11.1 6.1 2.2 2 1 1 3 3 3 0 BED zinc finger rve PF00665.26 EDN04606.1 - 8.6e-16 58.2 0.0 2.3e-15 56.8 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 EDN04606.1 - 3.5e-14 52.4 1.5 7.7e-14 51.3 1.5 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Integrase_H2C2 PF17921.1 EDN04606.1 - 2e-07 31.0 6.1 5.1e-06 26.5 6.1 2.6 1 1 0 1 1 1 1 Integrase zinc binding domain Mtf2_C PF14061.6 EDN04606.1 - 0.015 15.5 1.0 0.15 12.3 0.2 2.3 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 PSII_Pbs27 PF13326.6 EDN04606.1 - 0.1 12.9 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 Photosystem II Pbs27 Helicase_C PF00271.31 EDN04608.1 - 8.2e-13 48.7 0.1 2.3e-12 47.2 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain REV1_C PF16727.5 EDN04608.1 - 0.057 13.8 0.2 0.19 12.2 0.2 1.8 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain DUF1388 PF07142.12 EDN04609.1 - 0.02 14.8 19.3 0.44 10.5 1.8 3.8 2 2 2 4 4 4 0 Repeat of unknown function (DUF1388) Collagen PF01391.18 EDN04609.1 - 1.3 8.8 8.8 0.94 9.3 4.7 2.5 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) OrsD PF12013.8 EDN04611.1 - 6.1e-33 113.7 0.3 6.1e-33 113.7 0.3 1.9 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN04611.1 - 0.025 14.4 0.2 0.057 13.2 0.2 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Retrotran_gag_3 PF14244.6 EDN04612.1 - 0.025 14.4 0.1 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN04612.1 - 0.068 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Ribul_P_3_epim PF00834.19 EDN04613.1 - 4.3e-56 189.4 0.0 5.4e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 EDN04613.1 - 0.01 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 EDN04613.1 - 0.012 15.4 0.8 0.21 11.4 0.0 2.2 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain ThiG PF05690.14 EDN04613.1 - 0.015 14.7 0.1 0.021 14.2 0.1 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG SH3BGR PF04908.15 EDN04614.1 - 0.00027 21.1 0.0 0.00071 19.7 0.0 1.8 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein HyaE PF07449.11 EDN04614.1 - 0.03 14.3 0.1 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE AvrM_N PF18247.1 EDN04615.1 - 0.087 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain Aa_trans PF01490.18 EDN04616.1 - 1.9e-25 89.5 29.8 1.9e-24 86.1 29.8 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein RT_RNaseH PF17917.1 EDN04617.1 - 2e-39 134.1 0.4 2e-39 134.1 0.4 2.4 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN04617.1 - 1.3e-34 118.2 0.0 3.9e-34 116.7 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN04617.1 - 5.5e-28 98.0 0.4 1.2e-27 96.9 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN04617.1 - 3.4e-19 68.7 0.1 7.8e-19 67.5 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN04617.1 - 2e-14 53.8 0.0 6.1e-14 52.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN04617.1 - 1e-12 47.8 0.2 2.8e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN04617.1 - 5.9e-06 26.4 0.1 2.3e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Tudor-knot PF11717.8 EDN04617.1 - 0.0054 16.6 0.2 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Asp_protease_2 PF13650.6 EDN04617.1 - 0.2 12.3 0.0 0.41 11.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease NDUFA12 PF05071.16 EDN04617.1 - 0.37 11.7 4.4 3.6 8.5 4.4 2.8 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 NYD-SP28 PF14772.6 EDN04617.1 - 1.7 8.8 8.9 0.15 12.1 1.8 3.0 2 0 0 2 2 2 0 Sperm tail TSNAXIP1_N PF15739.5 EDN04617.1 - 4 7.8 11.0 0.86 10.0 0.5 3.2 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus Methyltransf_11 PF08241.12 EDN04618.1 - 5.6e-08 33.3 0.0 2e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04618.1 - 0.0032 18.1 0.0 0.0086 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain LSM PF01423.22 EDN04619.1 - 7.7e-18 63.9 0.7 1.1e-17 63.5 0.7 1.2 1 0 0 1 1 1 1 LSM domain LRR_9 PF14580.6 EDN04619.1 - 0.006 16.1 0.1 0.0069 15.9 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat DUF402 PF04167.13 EDN04619.1 - 0.012 15.8 0.7 0.016 15.4 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF402) Hfq PF17209.3 EDN04619.1 - 0.016 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Hfq protein DRMBL PF07522.14 EDN04620.1 - 1.1e-35 122.2 0.1 2.5e-35 121.0 0.1 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EDN04620.1 - 0.00014 21.5 0.1 0.00035 20.2 0.1 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RNF220 PF15926.5 EDN04620.1 - 0.01 15.5 0.1 0.026 14.2 0.1 1.7 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf-BED PF02892.15 EDN04621.1 - 0.00089 19.2 5.6 0.014 15.4 0.6 2.5 2 0 0 2 2 2 2 BED zinc finger Secretogranin_V PF05281.11 EDN04621.1 - 0.0025 17.5 0.4 0.0025 17.5 0.4 1.9 2 0 0 2 2 2 1 Neuroendocrine protein 7B2 precursor (Secretogranin V) Phage_clamp_A PF16790.5 EDN04621.1 - 0.019 15.4 0.0 0.046 14.2 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage clamp loader A subunit zf-C2H2_4 PF13894.6 EDN04621.1 - 1.2 10.2 4.9 0.84 10.7 1.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger CYSTM PF12734.7 EDN04622.1 - 0.00096 19.4 4.2 0.00096 19.4 4.2 3.3 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance Pex14_N PF04695.13 EDN04622.1 - 2 9.1 7.4 2.2 8.9 7.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CAP_N PF01213.19 EDN04622.1 - 9.6 5.6 7.5 10 5.5 7.5 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Joubert PF15392.6 EDN04623.1 - 7.1 6.2 9.5 9.6 5.8 9.1 1.4 1 1 0 1 1 1 0 Joubert syndrome-associated Abhydro_lipase PF04083.16 EDN04624.1 - 1.1e-11 44.1 0.0 2.1e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDN04624.1 - 1.1e-05 25.3 0.1 2.9e-05 23.9 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN04624.1 - 0.0069 17.0 3.8 0.014 16.0 3.8 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family MS_channel PF00924.18 EDN04625.1 - 6.8e-24 84.6 3.8 1.4e-23 83.6 3.8 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 EDN04625.1 - 0.00032 20.1 0.0 0.00074 18.9 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EDN04625.1 - 0.0012 18.2 0.3 0.0026 17.2 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EDN04625.1 - 0.0015 18.3 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EDN04625.1 - 0.028 14.9 0.2 0.075 13.5 0.2 1.7 1 0 0 1 1 1 0 EF-hand domain pair BBP1_C PF15272.6 EDN04625.1 - 0.039 13.8 0.5 0.078 12.8 0.5 1.4 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Tubulin PF00091.25 EDN04626.1 - 2.3e-64 217.2 0.0 3e-64 216.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDN04626.1 - 1.9e-45 154.1 0.0 2.9e-45 153.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EDN04626.1 - 0.00051 19.8 0.0 0.00094 18.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Mito_carr PF00153.27 EDN04627.1 - 1.3e-61 204.5 0.4 9.2e-20 70.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein TauD PF02668.16 EDN04628.1 - 2.6e-43 148.7 0.9 4.5e-43 148.0 0.2 1.8 2 1 1 3 3 3 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EDN04628.1 - 0.018 14.1 0.0 0.099 11.7 0.0 1.9 2 0 0 2 2 2 0 CsiD PhyH PF05721.13 EDN04628.1 - 0.11 12.8 0.0 15 5.7 0.0 2.6 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Glutaredoxin PF00462.24 EDN04629.1 - 6.1e-21 74.4 0.0 6e-18 64.8 0.0 2.4 2 1 0 2 2 2 2 Glutaredoxin Thioredoxin PF00085.20 EDN04629.1 - 6.6e-13 48.5 0.0 2.1e-12 47.0 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 EDN04629.1 - 3.3e-05 24.1 0.0 0.002 18.4 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EDN04629.1 - 0.012 15.6 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin domain OST3_OST6 PF04756.13 EDN04629.1 - 0.027 13.8 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HyaE PF07449.11 EDN04629.1 - 0.033 14.1 0.0 0.13 12.3 0.0 1.9 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE TrbC_Ftype PF09673.10 EDN04629.1 - 0.064 13.3 0.0 0.92 9.6 0.0 2.3 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin assembly protein Thioredoxin_2 PF13098.6 EDN04629.1 - 0.074 13.5 0.0 0.42 11.1 0.0 2.2 1 1 0 1 1 1 0 Thioredoxin-like domain RNase_T PF00929.24 EDN04630.1 - 7.5e-09 36.3 0.0 6e-08 33.4 0.0 2.2 1 1 0 1 1 1 1 Exonuclease FlxA PF14282.6 EDN04631.1 - 0.011 15.7 0.8 0.011 15.7 0.8 3.3 3 0 0 3 3 3 0 FlxA-like protein TSC22 PF01166.18 EDN04631.1 - 0.036 14.4 5.5 0.37 11.1 0.0 3.0 3 0 0 3 3 3 0 TSC-22/dip/bun family RILP PF11461.8 EDN04631.1 - 0.44 10.8 0.0 0.44 10.8 0.0 3.7 5 0 0 5 5 5 0 Rab interacting lysosomal protein Pkinase PF00069.25 EDN04632.1 - 9.3e-36 123.5 0.0 1.7e-21 76.8 0.0 3.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN04632.1 - 4.6e-13 49.0 0.0 9.2e-05 21.8 0.0 3.4 1 1 1 2 2 2 2 Protein tyrosine kinase FHA PF00498.26 EDN04632.1 - 1.6e-07 31.6 0.4 4.2e-07 30.2 0.2 2.0 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EDN04632.1 - 0.00038 20.7 0.0 0.00095 19.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF3716 PF12511.8 EDN04634.1 - 5.2e-17 61.6 5.6 9.4e-17 60.8 5.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Sporozoite_P67 PF05642.11 EDN04634.1 - 0.0076 14.4 2.1 0.0092 14.1 2.1 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen FAM176 PF14851.6 EDN04634.1 - 0.13 11.9 2.0 0.21 11.2 2.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 EDN04634.1 - 2.1 8.6 7.1 17 5.7 7.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nop14 PF04147.12 EDN04634.1 - 3.1 5.9 7.6 4.1 5.5 7.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EDN04634.1 - 3.1 6.0 6.8 4.4 5.5 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_34 PF05637.12 EDN04635.1 - 8.2e-32 110.8 0.0 1.1e-31 110.4 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family SelK_SelG PF10961.8 EDN04635.1 - 0.086 13.5 0.7 0.086 13.5 0.7 2.3 3 0 0 3 3 3 0 Selenoprotein SelK_SelG NDUFB10 PF10249.9 EDN04636.1 - 0.047 14.2 0.0 0.056 13.9 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 BRO1 PF03097.18 EDN04637.1 - 2.1e-06 26.8 0.0 8.3e-06 24.8 0.0 1.7 1 1 0 1 1 1 1 BRO1-like domain Bromo_TP PF07524.13 EDN04638.1 - 1.9e-09 37.4 0.0 3.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EDN04638.1 - 0.015 15.3 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TAFII55_N PF04658.13 EDN04639.1 - 1.9e-53 180.5 0.0 3.4e-53 179.7 0.0 1.4 1 0 0 1 1 1 1 TAFII55 protein conserved region F-box-like PF12937.7 EDN04640.1 - 0.038 13.9 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EDN04640.1 - 0.057 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box domain FMO-like PF00743.19 EDN04642.1 - 2.1e-19 69.3 0.0 3.1e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EDN04642.1 - 3.1e-16 59.4 0.6 2.5e-12 46.6 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EDN04642.1 - 1e-15 57.8 0.2 1.2e-14 54.3 0.2 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN04642.1 - 7.5e-15 54.9 0.3 8.2e-12 44.9 0.1 2.7 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN04642.1 - 7.7e-05 23.2 0.2 0.0032 18.0 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN04642.1 - 0.00054 19.3 0.6 0.51 9.5 0.1 2.3 2 0 0 2 2 2 2 Thi4 family SnoaL_4 PF13577.6 EDN04642.1 - 0.00071 19.7 0.4 0.082 13.0 0.0 3.4 3 0 0 3 3 3 1 SnoaL-like domain FAD_binding_2 PF00890.24 EDN04642.1 - 0.0038 16.4 0.5 0.17 10.9 0.0 2.5 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 EDN04642.1 - 0.011 15.9 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ofd1_CTDD PF10637.9 EDN04643.1 - 3.1e-101 338.0 0.4 1.5e-97 325.9 1.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EDN04643.1 - 3.5e-24 85.3 0.0 8.6e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EDN04643.1 - 4.5e-12 46.7 0.0 9.7e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BUD22 PF09073.10 EDN04643.1 - 0.1 11.9 22.2 0.18 11.2 22.2 1.3 1 0 0 1 1 1 0 BUD22 Trypan_PARP PF05887.11 EDN04644.1 - 0.052 13.5 5.1 0.06 13.3 5.1 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Hamartin PF04388.12 EDN04644.1 - 1.2 7.7 4.5 1.3 7.5 4.5 1.1 1 0 0 1 1 1 0 Hamartin protein FAP PF07174.11 EDN04644.1 - 3.7 6.9 18.7 5.5 6.4 18.7 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) SDF PF00375.18 EDN04648.1 - 2.5e-86 290.1 30.3 3.2e-86 289.8 30.3 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Kei1 PF08552.11 EDN04648.1 - 0.0041 17.0 0.6 1.3 8.9 0.0 2.4 2 0 0 2 2 2 2 Inositolphosphorylceramide synthase subunit Kei1 CAAD PF14159.6 EDN04648.1 - 0.014 15.2 2.9 0.016 15.0 0.2 2.6 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase UCH PF00443.29 EDN04649.1 - 1.7e-41 142.4 0.1 3.1e-41 141.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 EDN04649.1 - 1e-34 120.0 0.0 5.9e-34 117.4 0.0 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 EDN04649.1 - 3e-10 40.2 0.2 0.0001 22.1 0.3 2.3 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EDN04649.1 - 0.00018 21.6 0.0 0.00044 20.4 0.0 1.7 1 0 0 1 1 1 1 MATH domain Phosphodiest PF01663.22 EDN04650.1 - 5.5e-92 309.1 0.7 7e-92 308.8 0.7 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDN04650.1 - 0.001 18.6 0.0 0.16 11.4 0.0 2.3 1 1 1 2 2 2 2 Sulfatase KIP1 PF07765.12 EDN04650.1 - 0.027 14.6 0.0 0.093 12.9 0.0 1.9 1 0 0 1 1 1 0 KIP1-like protein Metalloenzyme PF01676.18 EDN04650.1 - 0.051 12.9 0.1 0.14 11.5 0.1 1.6 2 0 0 2 2 2 0 Metalloenzyme superfamily Pyr_redox_2 PF07992.14 EDN04651.1 - 3.2e-25 88.9 0.0 1.6e-24 86.7 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN04651.1 - 7.6e-14 52.0 0.2 6.4e-11 42.7 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN04651.1 - 6.2e-05 22.4 0.2 0.05 12.9 0.1 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDN04651.1 - 0.0002 21.1 0.3 0.35 10.4 0.1 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDN04651.1 - 0.00032 19.9 0.8 0.0011 18.1 0.0 2.2 2 1 1 3 3 3 1 Lycopene cyclase protein K_oxygenase PF13434.6 EDN04651.1 - 0.00074 18.8 0.0 0.0061 15.7 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EDN04651.1 - 0.0011 18.2 0.7 0.067 12.4 0.1 2.4 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EDN04651.1 - 0.0028 17.0 0.5 0.19 11.0 0.1 2.4 2 1 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EDN04651.1 - 0.01 15.1 0.0 0.27 10.5 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 EDN04651.1 - 0.016 15.4 0.4 1.5 9.1 0.0 2.8 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EDN04651.1 - 0.02 15.4 0.0 0.27 11.7 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding GIDA PF01134.22 EDN04651.1 - 0.088 11.9 0.0 2 7.4 0.0 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EDN04651.1 - 0.099 11.5 0.1 0.67 8.7 0.1 2.2 3 0 0 3 3 3 0 Tryptophan halogenase FAD_oxidored PF12831.7 EDN04651.1 - 0.12 11.7 1.1 1.4 8.2 0.2 2.6 3 0 0 3 3 3 0 FAD dependent oxidoreductase TrkA_N PF02254.18 EDN04651.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain HI0933_like PF03486.14 EDN04651.1 - 0.16 10.7 0.5 0.59 8.8 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.24 EDN04651.1 - 0.24 10.4 1.1 8.2 5.4 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain ABC_membrane PF00664.23 EDN04652.1 - 1.8e-84 283.6 29.1 3.5e-42 144.9 7.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDN04652.1 - 7.2e-69 230.6 0.1 6e-34 117.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDN04652.1 - 2.7e-17 63.0 2.8 4.3e-06 26.3 0.0 4.3 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN04652.1 - 1.5e-08 34.3 0.6 0.0011 18.7 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDN04652.1 - 2.3e-07 31.4 0.6 0.014 15.8 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EDN04652.1 - 1.5e-06 27.3 0.1 0.0026 16.6 0.0 2.6 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 EDN04652.1 - 1.9e-06 28.2 0.6 0.26 11.6 0.1 4.0 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EDN04652.1 - 4.2e-06 26.8 0.0 0.048 13.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 EDN04652.1 - 6.4e-06 26.0 4.0 0.065 12.9 0.2 4.2 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EDN04652.1 - 0.00022 21.8 0.0 0.56 10.7 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_21 PF13304.6 EDN04652.1 - 0.00024 21.0 0.9 0.13 12.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EDN04652.1 - 0.00032 20.9 2.6 0.026 14.6 0.1 2.9 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_25 PF13481.6 EDN04652.1 - 0.00038 20.1 0.0 0.58 9.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EDN04652.1 - 0.0004 20.8 1.2 4.7 7.6 0.2 4.3 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 EDN04652.1 - 0.00046 20.4 0.3 0.79 10.0 0.0 3.5 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EDN04652.1 - 0.00055 20.1 0.1 2.4 8.3 0.1 3.1 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EDN04652.1 - 0.00067 19.7 0.1 2.6 8.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EDN04652.1 - 0.0011 19.5 1.8 0.4 11.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EDN04652.1 - 0.0015 17.8 0.1 0.057 12.7 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin APS_kinase PF01583.20 EDN04652.1 - 0.004 17.0 0.1 3.4 7.5 0.0 2.4 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_15 PF13175.6 EDN04652.1 - 0.0072 16.1 0.0 0.23 11.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 EDN04652.1 - 0.008 15.6 0.1 2.7 7.3 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI G-alpha PF00503.20 EDN04652.1 - 0.0097 15.1 0.0 2.8 7.0 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_17 PF13207.6 EDN04652.1 - 0.036 14.5 0.0 9.9 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EDN04652.1 - 0.038 13.2 0.3 19 4.3 0.0 3.4 3 0 0 3 3 3 0 NB-ARC domain SRP54 PF00448.22 EDN04652.1 - 0.069 12.8 0.0 6.1 6.4 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EDN04652.1 - 0.074 13.1 0.9 13 5.9 0.0 3.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EDN04652.1 - 0.093 12.2 0.1 7.3 6.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 EDN04652.1 - 0.11 12.1 0.1 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 EDN04652.1 - 0.15 11.7 0.1 6.7 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EDN04652.1 - 0.22 11.3 0.4 17 5.1 0.1 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AMP-binding PF00501.28 EDN04653.1 - 9e-08 31.1 0.0 1.3e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EDN04654.1 - 3.3e-59 200.8 0.0 2e-34 119.0 0.0 2.5 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EDN04654.1 - 1.2e-24 86.4 0.7 9.2e-11 41.9 0.1 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site RTA1 PF04479.13 EDN04655.1 - 2.2e-34 118.9 10.1 2.9e-34 118.5 10.1 1.1 1 0 0 1 1 1 1 RTA1 like protein TRI12 PF06609.13 EDN04656.1 - 1.2e-09 37.2 18.3 3.6e-09 35.6 18.2 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EDN04656.1 - 1.7e-09 37.1 19.7 1.7e-09 37.1 19.7 3.6 3 1 1 5 5 5 3 Major Facilitator Superfamily Pox_A14 PF05767.12 EDN04656.1 - 0.0058 16.8 0.7 0.026 14.7 0.7 2.1 1 0 0 1 1 1 1 Poxvirus virion envelope protein A14 MaoC_dehydratas PF01575.19 EDN04657.1 - 5.9e-18 64.6 0.0 1.2e-17 63.6 0.0 1.5 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EDN04657.1 - 7.5e-05 22.9 0.0 0.0023 18.1 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase K_oxygenase PF13434.6 EDN04658.1 - 3.2e-115 384.9 0.0 3.9e-115 384.7 0.0 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EDN04658.1 - 2.7e-12 46.6 0.0 4.2e-11 42.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN04658.1 - 1.6e-09 37.4 0.0 3.6e-07 29.7 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN04658.1 - 9.6e-05 22.4 0.0 0.011 15.7 0.0 3.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDN04658.1 - 0.00021 21.8 0.0 0.045 14.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDN04658.1 - 0.093 11.8 0.0 0.96 8.4 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain AMP-binding PF00501.28 EDN04659.1 - 9.9e-102 340.7 0.0 1.2e-101 340.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN04659.1 - 2.1e-13 51.0 0.0 6e-13 49.6 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_8 PF13523.6 EDN04660.1 - 6.1e-47 158.9 2.8 8.9e-47 158.4 2.8 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CBFB_NFYA PF02045.15 EDN04664.1 - 1.9e-23 82.8 6.0 1.9e-23 82.8 6.0 2.7 2 1 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B PAT1 PF09770.9 EDN04664.1 - 1.2 7.4 41.0 1.7 6.8 41.0 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RNase_H PF00075.24 EDN04668.1 - 2.4e-12 47.2 0.0 5e-12 46.2 0.0 1.5 1 1 0 1 1 1 1 RNase H RVT_1 PF00078.27 EDN04669.1 - 9.1e-34 116.9 0.0 3.7e-33 114.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN04669.1 - 8.9e-12 45.4 0.0 1.9e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN04669.1 - 6.5e-10 38.9 0.0 2e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN04669.1 - 0.014 15.8 0.7 0.1 13.0 0.3 2.5 2 0 0 2 2 2 0 ORF 12 gene product N-terminal DUF1275 PF06912.11 EDN04671.1 - 6.7e-43 146.9 8.0 8.7e-43 146.5 8.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Wzz PF02706.15 EDN04671.1 - 0.11 12.9 0.1 0.37 11.1 0.0 2.0 2 0 0 2 2 2 0 Chain length determinant protein Acyl-CoA_dh_1 PF00441.24 EDN04672.1 - 6.5e-18 65.4 6.9 1.3e-11 44.9 1.3 2.3 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDN04672.1 - 4.1e-13 50.0 0.9 8.1e-13 49.0 0.1 2.0 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EDN04672.1 - 2.5e-09 37.2 0.0 5.1e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EDN04672.1 - 4.4e-06 27.0 5.5 0.00014 22.1 0.3 2.3 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Glucosaminidase PF01832.20 EDN04672.1 - 0.34 11.4 1.9 1.4 9.5 1.9 2.0 1 1 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MFS_1 PF07690.16 EDN04673.1 - 5e-33 114.5 25.5 8.2e-33 113.8 25.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily adh_short PF00106.25 EDN04675.1 - 1.3e-26 93.3 0.1 1.5e-26 93.0 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN04675.1 - 3.9e-24 85.5 0.0 5.1e-24 85.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN04675.1 - 3.2e-07 30.5 0.1 3.9e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 KR domain MlaE PF02405.16 EDN04675.1 - 0.14 11.8 2.7 0.52 10.0 0.0 2.3 2 0 0 2 2 2 0 Permease MlaE CAP_N PF01213.19 EDN04676.1 - 4.5 6.7 8.4 9.8 5.5 5.0 2.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal ECH_1 PF00378.20 EDN04678.1 - 2.1e-10 40.4 0.1 2.7e-10 40.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN04678.1 - 9e-07 28.7 0.0 1.1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase RRM_1 PF00076.22 EDN04680.1 - 0.06 13.2 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Snf7 PF03357.21 EDN04682.1 - 1e-19 70.8 14.7 1.4e-19 70.3 14.0 1.5 1 1 1 2 2 2 1 Snf7 DUF2730 PF10805.8 EDN04682.1 - 1.1 9.3 5.5 7.8 6.7 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) MerR-DNA-bind PF09278.11 EDN04682.1 - 3.4 8.3 13.7 5.4 7.6 0.0 4.1 5 0 0 5 5 5 0 MerR, DNA binding TPR_MLP1_2 PF07926.12 EDN04682.1 - 6.4 6.9 14.5 0.13 12.3 5.5 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CS PF04969.16 EDN04683.1 - 0.00048 21.1 0.0 0.00078 20.4 0.0 1.4 1 0 0 1 1 1 1 CS domain DFRP_C PF16543.5 EDN04686.1 - 1.7e-26 92.5 5.4 1.7e-26 92.5 5.4 3.9 3 2 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 EDN04686.1 - 5.8e-06 26.0 9.3 0.00015 21.5 2.0 3.2 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH PF00642.24 EDN04686.1 - 1.4e-05 24.9 1.9 1.4e-05 24.9 1.9 2.3 3 1 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDN04686.1 - 6.4e-05 22.9 5.9 6.4e-05 22.9 5.9 3.1 3 0 0 3 3 3 2 Zinc finger domain Torus PF16131.5 EDN04686.1 - 0.00043 20.9 8.1 0.00043 20.9 8.1 3.8 2 2 2 4 4 4 2 Torus domain zf-CCCH_2 PF14608.6 EDN04686.1 - 0.0083 16.6 12.3 0.062 13.8 3.2 2.9 2 1 0 2 2 2 2 RNA-binding, Nab2-type zinc finger PTPS PF01242.19 EDN04686.1 - 0.024 14.6 0.7 1.3 9.0 0.1 2.4 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase FYVE_2 PF02318.16 EDN04686.1 - 0.23 11.7 6.5 4.9 7.4 0.0 3.2 3 0 0 3 3 3 0 FYVE-type zinc finger zf-CCCH_3 PF15663.5 EDN04686.1 - 0.24 11.6 9.6 0.2 11.9 1.0 2.8 2 1 0 3 3 3 0 Zinc-finger containing family Ost4 PF10215.9 EDN04687.1 - 5.4e-20 70.9 0.6 7e-20 70.6 0.6 1.2 1 0 0 1 1 1 1 Oligosaccaryltransferase FOXP-CC PF16159.5 EDN04688.1 - 0.018 15.7 2.5 0.22 12.2 0.8 3.1 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EDN04688.1 - 0.024 14.8 0.0 0.049 13.8 0.0 1.5 1 0 0 1 1 1 0 Aberrant zinc-finger Nop53 PF07767.11 EDN04688.1 - 0.06 12.7 25.3 0.15 11.4 25.3 1.7 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Usp PF00582.26 EDN04688.1 - 0.64 10.5 3.0 2.3 8.7 3.0 1.9 1 0 0 1 1 1 0 Universal stress protein family Ribosomal_L26 PF16906.5 EDN04689.1 - 3.5e-39 133.2 3.6 4.3e-39 132.9 3.6 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EDN04689.1 - 9.6e-08 31.7 1.6 9.6e-08 31.7 1.6 1.9 2 0 0 2 2 2 1 KOW motif DUF1223 PF06764.11 EDN04689.1 - 0.035 14.1 0.1 0.039 14.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) Synaptobrevin PF00957.21 EDN04690.1 - 2.8e-29 100.8 0.0 4e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EDN04690.1 - 9.8e-18 64.0 0.0 1.6e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DDE_1 PF03184.19 EDN04691.1 - 6.6e-34 117.1 0.0 1.2e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN04691.1 - 1.1e-10 41.3 0.0 2.3e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN04691.1 - 2.3e-06 27.3 0.1 5.6e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN04691.1 - 5.5e-06 26.2 0.0 0.00018 21.3 0.0 2.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_28 PF13518.6 EDN04691.1 - 0.08 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DEAD PF00270.29 EDN04692.1 - 3.5e-09 36.7 0.0 5e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2759 PF10958.8 EDN04693.1 - 0.049 13.4 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) CPSase_L_D2 PF02786.17 EDN04695.1 - 1e-112 374.8 0.1 9.5e-84 280.1 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EDN04695.1 - 6.7e-48 161.7 0.0 1.4e-47 160.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EDN04695.1 - 1.6e-46 158.5 0.0 3.6e-46 157.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EDN04695.1 - 7.5e-45 152.6 0.0 1.5e-44 151.6 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EDN04695.1 - 1e-38 132.4 0.0 2.4e-38 131.2 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EDN04695.1 - 3.1e-30 105.3 0.0 6.8e-30 104.2 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EDN04695.1 - 5.1e-22 77.9 0.0 2.8e-21 75.5 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EDN04695.1 - 8.1e-17 61.4 0.2 2.5e-08 33.7 0.0 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDN04695.1 - 7.3e-15 55.0 0.0 6.1e-07 29.2 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EDN04695.1 - 5.2e-09 35.9 0.0 0.00037 20.2 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EDN04695.1 - 1.5e-05 24.9 0.0 0.065 13.0 0.0 2.5 2 0 0 2 2 2 2 Peptidase C26 ATP-grasp_3 PF02655.14 EDN04695.1 - 0.00021 21.4 0.2 0.44 10.6 0.0 2.8 3 0 0 3 3 2 2 ATP-grasp domain DJ-1_PfpI PF01965.24 EDN04695.1 - 0.00098 19.0 0.0 0.18 11.6 0.0 3.5 3 0 0 3 3 3 1 DJ-1/PfpI family RimK PF08443.11 EDN04695.1 - 0.024 14.2 0.0 2.2 7.9 0.0 2.5 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Peptidase_C25_C PF03785.14 EDN04695.1 - 0.087 12.7 0.2 1.1 9.2 0.2 2.9 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain Neur_chan_memb PF02932.16 EDN04696.1 - 0.55 10.2 2.0 0.61 10.1 2.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 EDN04696.1 - 2.7 7.1 3.4 3 7.0 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 EDN04696.1 - 3 8.9 5.1 8.5 7.4 5.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 EDN04696.1 - 8.1 5.1 4.8 8.7 5.0 4.8 1.1 1 0 0 1 1 1 0 Presenilin SGL PF08450.12 EDN04697.1 - 1.5e-20 73.8 0.2 2.1e-20 73.3 0.2 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EDN04697.1 - 0.014 15.4 0.0 0.055 13.4 0.0 1.9 2 0 0 2 2 2 0 Esterase-like activity of phytase ABC_tran PF00005.27 EDN04698.1 - 1.6e-24 87.0 0.0 7.7e-11 42.7 0.0 3.1 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EDN04698.1 - 1.5e-06 28.3 3.0 0.005 16.7 0.1 3.1 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDN04698.1 - 8.6e-05 22.7 0.0 0.052 13.8 0.0 2.5 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EDN04698.1 - 0.055 13.2 0.7 0.15 11.8 0.7 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ploopntkinase1 PF18748.1 EDN04698.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 AAA_13 PF13166.6 EDN04698.1 - 0.18 10.4 0.0 0.28 9.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDN04698.1 - 5.3 7.5 5.4 0.91 10.0 1.3 1.7 2 0 0 2 2 2 0 AAA domain Exo84_C PF16528.5 EDN04699.1 - 2.1e-66 223.7 1.2 2.1e-66 223.7 1.2 1.7 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EDN04699.1 - 3.8e-18 65.3 3.1 1.2e-17 63.8 3.1 1.9 1 0 0 1 1 1 1 Vps51/Vps67 DUF2594 PF10769.9 EDN04699.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2594) COG2 PF06148.11 EDN04699.1 - 0.084 13.0 0.5 0.24 11.5 0.1 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 BST2 PF16716.5 EDN04699.1 - 0.22 12.2 2.7 0.69 10.5 2.7 1.9 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 CRIC_ras_sig PF10534.9 EDN04699.1 - 0.36 11.0 2.5 0.51 10.6 0.3 2.4 2 0 0 2 2 2 0 Connector enhancer of kinase suppressor of ras Prominin PF05478.11 EDN04699.1 - 0.43 8.5 4.2 0.15 10.0 0.8 1.7 2 0 0 2 2 2 0 Prominin FapA PF03961.13 EDN04699.1 - 0.48 9.0 3.5 0.14 10.7 0.5 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 EDN04699.1 - 2.6 7.5 6.0 1.3 8.5 1.2 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 EDN04699.1 - 9 6.3 8.6 1.4 8.9 2.1 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MAS20 PF02064.15 EDN04700.1 - 1.2e-42 145.0 0.1 1.5e-42 144.8 0.1 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor Glyco_hydro_72 PF03198.14 EDN04701.1 - 8.1e-118 393.2 0.0 1e-117 392.9 0.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EDN04701.1 - 0.18 11.2 0.1 1.5 8.2 0.1 2.1 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) F-box-like PF12937.7 EDN04702.1 - 5.5e-12 45.4 0.4 1.2e-11 44.3 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN04702.1 - 1.5e-11 43.9 0.2 3.1e-11 42.9 0.2 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDN04702.1 - 0.0016 18.4 0.0 0.0038 17.1 0.0 1.7 1 0 0 1 1 1 1 F-box Imm49 PF15575.6 EDN04702.1 - 0.15 11.8 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 49 Mre11_DNA_bind PF04152.14 EDN04703.1 - 1.9e-55 187.8 1.5 4e-55 186.7 1.5 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EDN04703.1 - 5.2e-13 50.0 1.2 1.5e-12 48.5 1.3 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN04703.1 - 0.0012 19.1 0.0 0.0075 16.5 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Aldedh PF00171.22 EDN04705.1 - 7.8e-173 575.2 3.5 1.8e-172 574.0 3.5 1.5 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Metallophos PF00149.28 EDN04706.1 - 3.3e-28 99.6 0.0 6.6e-28 98.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EDN04706.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Ctr PF04145.15 EDN04707.1 - 2e-32 112.9 4.3 2.5e-32 112.6 4.3 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Transgly_assoc PF04226.13 EDN04707.1 - 0.43 10.9 5.7 5.5 7.3 0.6 2.7 2 1 1 3 3 3 0 Transglycosylase associated protein Forkhead_N PF08430.12 EDN04707.1 - 2.6 8.7 16.4 3.6 8.2 16.4 1.2 1 0 0 1 1 1 0 Forkhead N-terminal region Nexin_C PF08628.12 EDN04708.1 - 0.0037 17.8 0.6 0.0044 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal RVT_1 PF00078.27 EDN04709.1 - 7.6e-33 113.9 0.0 1.2e-32 113.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN04709.1 - 6.1e-12 45.4 0.0 1.8e-11 43.9 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN04709.1 - 7.1e-12 45.7 0.0 1.5e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN04709.1 - 0.05 14.0 0.8 0.22 11.9 0.5 2.2 2 0 0 2 2 2 0 ORF 12 gene product N-terminal Aminotran_3 PF00202.21 EDN04713.1 - 4.3e-120 401.1 0.0 4.9e-120 400.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDN04713.1 - 0.096 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Spt4 PF06093.13 EDN04714.1 - 1e-31 108.8 0.2 1.7e-31 108.1 0.2 1.3 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 EDN04714.1 - 0.026 14.5 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 Coronavirus gene 5 protein ETRAMP PF09716.10 EDN04714.1 - 0.065 13.3 0.4 0.1 12.7 0.4 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Metallophos PF00149.28 EDN04715.1 - 2.2e-35 123.0 0.1 3.1e-35 122.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EDN04715.1 - 9.4e-32 109.2 0.0 2e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 EDN04715.1 - 8.6e-09 34.9 5.1 0.00021 21.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN04715.1 - 9.8e-08 31.6 5.1 0.017 15.2 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDN04715.1 - 2.7e-05 23.8 2.5 0.022 14.4 0.3 3.1 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 EDN04715.1 - 9.6e-05 22.8 0.5 0.76 10.3 0.1 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDN04715.1 - 0.00025 21.1 0.2 0.005 17.0 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDN04715.1 - 0.0067 16.7 0.4 5 7.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN04715.1 - 0.011 16.4 5.2 0.69 10.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN04715.1 - 0.024 15.3 1.1 8.7 7.2 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDN04715.1 - 0.04 14.1 0.9 0.17 12.2 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN04715.1 - 0.11 13.4 1.3 5.7 8.0 0.2 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF89 PF01937.19 EDN04716.1 - 3.1e-133 444.1 0.0 3.8e-133 443.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Cut12 PF11500.8 EDN04717.1 - 1e-45 155.3 14.3 1e-45 155.3 14.3 3.5 3 1 0 3 3 3 1 Spindle pole body formation-associated protein Nucleoporin_FG2 PF15967.5 EDN04717.1 - 0.0035 16.0 2.9 0.0065 15.1 2.9 1.4 1 0 0 1 1 1 1 Nucleoporin FG repeated region HGTP_anticodon2 PF12745.7 EDN04718.1 - 1.7e-83 280.2 1.4 1.7e-83 280.2 1.4 2.3 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EDN04718.1 - 3.3e-33 115.2 6.4 1.1e-10 41.3 0.0 5.8 5 1 1 6 6 6 4 Protein kinase domain Pkinase_Tyr PF07714.17 EDN04718.1 - 4.8e-14 52.3 0.0 4.1e-06 26.3 0.0 3.8 2 1 0 2 2 2 2 Protein tyrosine kinase RWD PF05773.22 EDN04718.1 - 5.1e-14 52.6 0.0 2.3e-13 50.5 0.0 2.2 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.6 EDN04718.1 - 3.7e-13 49.4 0.2 1.9e-12 47.1 0.0 2.1 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EDN04718.1 - 2e-06 27.8 0.1 5.2e-06 26.5 0.1 1.8 1 0 0 1 1 1 1 Anticodon binding domain DUF5041 PF16444.5 EDN04718.1 - 0.12 12.6 0.2 0.27 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5041) Torus PF16131.5 EDN04719.1 - 2.9e-09 37.6 5.9 1.2e-08 35.6 0.6 3.0 3 1 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EDN04719.1 - 1.6e-08 34.2 0.0 3.5e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDN04719.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Alpha_Helical PF18489.1 EDN04719.1 - 0.19 11.9 0.3 0.47 10.6 0.0 1.7 2 0 0 2 2 2 0 Alpha helical domain MMR_HSR1_Xtn PF16897.5 EDN04720.1 - 8.7e-36 122.2 2.4 5.4e-35 119.6 0.6 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EDN04720.1 - 4.8e-21 74.6 0.5 9.6e-21 73.6 0.1 1.7 2 0 0 2 2 2 1 TGS domain MMR_HSR1 PF01926.23 EDN04720.1 - 1.7e-20 73.2 0.0 3.7e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN04720.1 - 6.1e-13 48.6 0.0 9.9e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDN04720.1 - 7.8e-05 22.8 0.3 0.2 11.7 0.0 2.5 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EDN04720.1 - 0.076 12.3 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 AIG1 family MCM PF00493.23 EDN04720.1 - 0.078 12.1 0.0 0.2 10.7 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain MeaB PF03308.16 EDN04720.1 - 0.087 11.8 0.1 0.19 10.7 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DnaJ_C PF01556.18 EDN04721.1 - 1.2e-36 126.0 0.6 1.6e-36 125.6 0.6 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDN04721.1 - 5e-27 93.8 2.6 8.3e-27 93.1 2.6 1.4 1 0 0 1 1 1 1 DnaJ domain PIG-X PF08320.12 EDN04722.1 - 3.8e-69 232.8 0.0 4.9e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 PIG-X / PBN1 Asp_protease_2 PF13650.6 EDN04722.1 - 0.15 12.7 0.0 0.31 11.7 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease RFX_DNA_binding PF02257.15 EDN04723.1 - 3e-24 85.5 0.3 6.4e-24 84.4 0.3 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain TB2_DP1_HVA22 PF03134.19 EDN04724.1 - 3.4e-28 97.4 9.8 6.3e-28 96.5 9.8 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family ATG101 PF07855.12 EDN04725.1 - 3.9e-56 189.3 0.0 4.7e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 DUF2922 PF11148.8 EDN04725.1 - 0.073 12.8 0.2 0.14 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) TraT PF05818.12 EDN04725.1 - 0.15 11.7 3.4 0.26 10.9 3.4 1.4 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Keratin_2_head PF16208.5 EDN04725.1 - 3.5 7.7 27.4 5.1 7.2 27.4 1.1 1 0 0 1 1 1 0 Keratin type II head Peroxin-3 PF04882.12 EDN04726.1 - 9.1e-54 183.2 0.3 1e-53 183.1 0.3 1.0 1 0 0 1 1 1 1 Peroxin-3 Na_H_Exchanger PF00999.21 EDN04727.1 - 4.7e-60 203.4 41.6 7.1e-60 202.8 41.6 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Peroxin-3 PF04882.12 EDN04727.1 - 1.1e-54 186.3 1.3 1.5e-54 185.7 1.3 1.2 1 0 0 1 1 1 1 Peroxin-3 SUIM_assoc PF16619.5 EDN04727.1 - 5 7.3 6.8 14 5.8 0.7 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 MFS_1 PF07690.16 EDN04729.1 - 2.8e-23 82.4 12.2 3.7e-23 82.0 12.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ThiF PF00899.21 EDN04731.1 - 1.7e-26 93.1 0.0 2.2e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Ytp1 PF10355.9 EDN04732.1 - 5.4e-71 239.0 23.4 6.1e-71 238.9 15.5 2.6 2 1 0 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EDN04732.1 - 2.6e-33 113.9 3.5 2.6e-33 113.9 3.5 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) Ion_trans_2 PF07885.16 EDN04732.1 - 0.11 12.5 0.2 0.11 12.5 0.2 4.0 4 0 0 4 4 4 0 Ion channel DUF1664 PF07889.12 EDN04733.1 - 0.047 13.7 1.8 2.9 7.9 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 EDN04733.1 - 0.05 13.9 2.0 0.1 12.9 1.2 1.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tweety PF04906.13 EDN04733.1 - 0.051 12.2 1.6 0.12 11.0 0.9 1.7 2 0 0 2 2 2 0 Tweety Cytochrom_C PF00034.21 EDN04733.1 - 0.094 13.9 0.5 0.71 11.1 0.0 2.4 2 0 0 2 2 2 0 Cytochrome c MAD PF05557.13 EDN04733.1 - 0.11 10.9 13.0 1.1 7.6 11.8 2.0 2 0 0 2 2 2 0 Mitotic checkpoint protein Exonuc_VII_L PF02601.15 EDN04733.1 - 0.11 12.0 5.4 0.16 11.5 5.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Rx_N PF18052.1 EDN04733.1 - 0.23 11.8 2.7 0.27 11.6 1.1 2.0 2 0 0 2 2 2 0 Rx N-terminal domain FlaC_arch PF05377.11 EDN04733.1 - 0.28 11.6 1.7 23 5.5 0.3 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 EDN04733.1 - 0.32 11.6 6.3 0.74 10.4 5.0 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Fib_alpha PF08702.10 EDN04733.1 - 0.35 11.1 5.2 4.9 7.3 2.7 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Mgr1 PF08602.10 EDN04733.1 - 0.43 9.3 3.6 0.68 8.7 3.6 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Nup88 PF10168.9 EDN04733.1 - 0.64 7.8 7.3 0.91 7.3 7.3 1.1 1 0 0 1 1 1 0 Nuclear pore component COG2 PF06148.11 EDN04733.1 - 0.82 9.8 5.3 1.5 8.9 4.7 1.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 T2SSF PF00482.23 EDN04733.1 - 1.2 9.1 3.1 2 8.4 3.1 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F TMPIT PF07851.13 EDN04733.1 - 1.5 8.0 6.8 2.6 7.2 6.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein Csm1_N PF18504.1 EDN04733.1 - 2.5 8.5 9.6 0.79 10.1 1.4 2.7 3 0 0 3 3 3 0 Csm1 N-terminal domain PRKG1_interact PF15898.5 EDN04733.1 - 3.8 8.5 13.6 13 6.7 10.6 2.9 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain V_ATPase_I PF01496.19 EDN04733.1 - 9.8 4.0 6.3 12 3.6 6.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cyclin_N PF00134.23 EDN04734.1 - 0.014 15.1 0.0 0.11 12.2 0.0 2.1 2 0 0 2 2 2 0 Cyclin, N-terminal domain TFIIB PF00382.19 EDN04734.1 - 0.023 14.7 0.0 0.8 9.8 0.0 2.6 2 1 0 2 2 2 0 Transcription factor TFIIB repeat Autophagy_act_C PF03987.15 EDN04735.1 - 6.7e-16 58.6 0.2 3.3e-15 56.4 0.1 1.9 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EDN04735.1 - 8e-16 57.2 0.5 1.5e-15 56.4 0.5 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Glycos_transf_2 PF00535.26 EDN04736.1 - 8e-23 81.1 0.0 7.4e-21 74.7 0.0 3.0 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDN04736.1 - 8.2e-08 32.4 0.0 0.0016 18.4 0.0 3.1 2 1 1 3 3 3 2 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EDN04736.1 - 0.078 13.5 0.0 0.28 11.7 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase family 2 DUF4679 PF15728.5 EDN04736.1 - 0.12 11.3 0.8 0.19 10.8 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) HTH_8 PF02954.19 EDN04737.1 - 0.012 15.3 0.1 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_psq PF05225.16 EDN04737.1 - 0.063 13.0 0.0 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 EDN04737.1 - 0.11 12.6 0.0 0.41 10.7 0.0 2.1 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain Mif2_N PF15624.6 EDN04738.1 - 0.3 11.8 3.0 0.37 11.5 2.9 1.3 1 1 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Presenilin PF01080.17 EDN04738.1 - 6.8 5.3 5.8 7.3 5.2 5.8 1.0 1 0 0 1 1 1 0 Presenilin RT_RNaseH PF17917.1 EDN04740.1 - 2e-39 134.1 0.4 2e-39 134.1 0.4 2.5 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN04740.1 - 1.2e-34 118.3 0.0 3.9e-34 116.7 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN04740.1 - 5.5e-28 98.0 0.4 1.2e-27 96.9 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN04740.1 - 3.4e-19 68.7 0.1 7.8e-19 67.5 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN04740.1 - 2e-14 53.8 0.0 6.1e-14 52.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN04740.1 - 1e-12 47.8 0.2 2.8e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN04740.1 - 5.9e-06 26.4 0.1 2.3e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Tudor-knot PF11717.8 EDN04740.1 - 0.0055 16.6 0.2 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Asp_protease_2 PF13650.6 EDN04740.1 - 0.21 12.2 0.0 0.41 11.3 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease NDUFA12 PF05071.16 EDN04740.1 - 0.38 11.6 4.4 3.6 8.5 4.4 2.8 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 TSNAXIP1_N PF15739.5 EDN04740.1 - 3.2 8.1 10.5 0.86 10.0 0.5 3.2 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus APH PF01636.23 EDN04741.1 - 4.6e-07 30.0 0.0 7.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN04741.1 - 0.00037 20.2 0.0 0.00053 19.6 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EDN04741.1 - 0.1 11.9 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 Ecdysteroid kinase DDE_1 PF03184.19 EDN04742.1 - 1.5e-19 70.3 0.4 3.1e-19 69.3 0.1 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN04742.1 - 4.7e-11 42.5 0.0 9.3e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN04742.1 - 2.2e-07 30.5 0.1 4.5e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN04742.1 - 0.00018 21.3 0.1 0.0023 17.7 0.0 2.4 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_23 PF13384.6 EDN04742.1 - 0.31 10.9 1.4 1.1 9.2 0.1 2.6 3 0 0 3 3 3 0 Homeodomain-like domain NUDIX PF00293.28 EDN04743.1 - 1.1e-06 28.8 0.0 8.5e-06 25.8 0.0 2.1 1 1 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 EDN04744.1 - 1.5e-16 60.7 0.0 2.4e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF3433 PF11915.8 EDN04745.1 - 5.5e-15 55.6 1.5 5.5e-15 55.6 1.5 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF3433) DUF588 PF04535.12 EDN04745.1 - 0.0053 16.5 0.9 0.013 15.2 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF588) HAD_2 PF13419.6 EDN04746.1 - 1.5e-18 67.5 0.0 2e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN04746.1 - 1.4e-08 35.3 0.1 3.7e-08 33.9 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.18 EDN04746.1 - 8.1e-07 28.9 0.0 0.00016 21.5 0.0 2.1 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase Hydrolase_like PF13242.6 EDN04746.1 - 0.02 14.9 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Rit1_C PF17184.4 EDN04747.1 - 1.8e-101 339.1 0.0 4.6e-101 337.8 0.0 1.6 2 0 0 2 2 2 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EDN04747.1 - 4.1e-33 114.0 0.0 8.6e-33 112.9 0.0 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain BTB PF00651.31 EDN04748.1 - 0.0045 17.2 0.1 0.011 15.9 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain RVT_1 PF00078.27 EDN04749.1 - 0.00044 19.8 0.0 0.00088 18.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EDN04750.1 - 1.5e-35 122.8 0.0 2.3e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN04750.1 - 3.8e-13 49.3 0.0 1.2e-12 47.7 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN04750.1 - 0.00024 20.7 0.1 0.00041 19.9 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN04750.1 - 3.2 8.0 8.7 1.4 9.2 4.8 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN04750.1 - 6.2 6.6 6.4 5.8 6.7 1.7 2.5 2 0 0 2 2 2 0 Zinc knuckle FlxA PF14282.6 EDN04751.1 - 3.5 7.7 12.4 0.16 12.0 4.2 2.3 2 0 0 2 2 2 0 FlxA-like protein MerR-DNA-bind PF09278.11 EDN04751.1 - 8 7.1 11.1 0.34 11.5 2.2 3.2 3 0 0 3 3 3 0 MerR, DNA binding RVP_2 PF08284.11 EDN04752.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Urease_linker PF18473.1 EDN04752.1 - 0.41 10.6 1.0 0.88 9.5 1.0 1.5 1 0 0 1 1 1 0 Urease subunit beta-alpha linker domain Transp_cyt_pur PF02133.15 EDN04756.1 - 1.1e-74 251.8 18.2 1.4e-74 251.5 9.6 2.0 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin Urb2 PF10441.9 EDN04757.1 - 4.4e-51 173.7 1.3 3e-50 171.0 0.1 2.6 2 0 0 2 2 2 1 Urb2/Npa2 family DUF543 PF04418.12 EDN04758.1 - 1.1e-26 92.6 0.0 1.3e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Copper-fist PF00649.18 EDN04759.1 - 1.2e-17 63.0 0.4 3.4e-17 61.7 0.4 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain Metallothio_2 PF01439.18 EDN04759.1 - 0.33 11.9 21.3 0.22 12.4 1.7 3.8 4 0 0 4 4 4 0 Metallothionein Exo_endo_phos_2 PF14529.6 EDN04762.1 - 9.9e-13 48.0 0.0 2.8e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DASH_Dam1 PF08653.10 EDN04762.1 - 0.092 12.6 0.2 3 7.7 0.0 2.5 2 0 0 2 2 2 0 DASH complex subunit Dam1 Swm2 PF17083.5 EDN04763.1 - 0.11 12.5 0.2 0.17 11.9 0.2 1.2 1 0 0 1 1 1 0 Nucleolar protein Swm2 Rep-A_N PF04057.12 EDN04763.1 - 0.2 11.7 0.1 0.32 11.0 0.1 1.2 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Aldo_ket_red PF00248.21 EDN04764.1 - 2.5e-18 66.3 0.0 3.1e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family SLAC1 PF03595.17 EDN04765.1 - 2.6e-67 227.4 38.0 1.8e-44 152.3 18.3 2.0 1 1 0 2 2 2 2 Voltage-dependent anion channel EamA PF00892.20 EDN04767.1 - 4.3e-07 30.2 1.2 4.3e-07 30.2 1.2 3.2 2 1 0 2 2 2 1 EamA-like transporter family Nuc_sug_transp PF04142.15 EDN04767.1 - 0.0065 15.7 0.1 0.0065 15.7 0.1 2.0 2 0 0 2 2 2 1 Nucleotide-sugar transporter CSG2 PF16965.5 EDN04767.1 - 0.0073 15.3 12.9 0.012 14.6 0.6 2.4 2 1 0 2 2 2 2 Ceramide synthase regulator PgaD PF13994.6 EDN04767.1 - 0.012 15.7 0.0 0.012 15.7 0.0 2.3 3 0 0 3 3 3 0 PgaD-like protein DUF4131 PF13567.6 EDN04767.1 - 0.27 10.8 3.2 0.38 10.4 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) PRRSV_Env PF02340.15 EDN04767.1 - 1.5 8.2 9.7 0.41 10.0 2.0 2.6 2 1 1 3 3 3 0 PRRSV putative envelope protein DUF202 PF02656.15 EDN04767.1 - 3 8.3 21.7 0.53 10.8 6.3 4.5 2 2 2 4 4 4 0 Domain of unknown function (DUF202) DUF5480 PF17576.2 EDN04767.1 - 4.5 7.3 9.8 0.27 11.2 2.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5480) Actin PF00022.19 EDN04768.1 - 1.2e-112 376.5 0.0 8.3e-112 373.8 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDN04768.1 - 0.051 12.4 0.0 0.29 9.9 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein DUF3425 PF11905.8 EDN04769.1 - 4.1e-25 88.1 2.7 7e-25 87.4 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EDN04769.1 - 0.18 11.9 11.3 0.64 10.1 11.3 1.9 1 1 0 1 1 1 0 bZIP transcription factor Methyltransf_31 PF13847.6 EDN04770.1 - 4.4e-10 39.6 0.0 1.3e-08 34.8 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN04770.1 - 9.8e-10 38.5 0.0 1.9e-09 37.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN04770.1 - 1.1e-07 32.4 0.0 9.4e-07 29.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN04770.1 - 1.2e-07 32.4 0.1 9.5e-07 29.5 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04770.1 - 8.9e-06 26.3 0.0 0.00014 22.5 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain DUF4734 PF15881.5 EDN04770.1 - 0.1 12.8 0.3 0.21 11.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) SelP_N PF04592.14 EDN04770.1 - 1.3 8.4 9.4 1.9 7.8 9.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region GTP_cyclohydro2 PF00925.20 EDN04771.1 - 2.9e-32 111.5 0.1 3.3e-32 111.3 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II GTP_cyclohydro2 PF00925.20 EDN04772.1 - 0.0038 16.8 0.0 0.0055 16.3 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF1325 PF07039.11 EDN04773.1 - 1.7e-35 122.0 0.0 2.5e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 EDN04773.1 - 0.0073 16.1 0.2 0.018 14.8 0.1 1.7 2 0 0 2 2 2 1 Lamin-B receptor of TUDOR domain Tudor_3 PF18115.1 EDN04773.1 - 0.033 14.0 0.1 0.095 12.6 0.0 1.8 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain PMI_typeI PF01238.21 EDN04774.1 - 1.3e-143 478.7 0.0 1.6e-143 478.5 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Abhydrolase_3 PF07859.13 EDN04775.1 - 3.9e-21 75.9 0.0 5.8e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDN04775.1 - 2e-16 59.8 0.0 2.6e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase DUF2974 PF11187.8 EDN04775.1 - 0.0086 15.7 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PGAP1 PF07819.13 EDN04775.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Coatomer_E PF04733.14 EDN04776.1 - 1.1e-62 212.1 1.9 1.3e-62 211.9 1.9 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EDN04776.1 - 5.1e-08 33.3 9.9 0.00041 20.8 2.2 3.9 4 1 0 4 4 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN04776.1 - 8.2e-07 29.2 0.0 0.17 12.1 0.0 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDN04776.1 - 1.9e-05 24.9 3.0 1.2 9.5 0.0 4.5 3 2 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN04776.1 - 2.6e-05 24.8 6.3 0.037 14.7 0.0 4.1 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDN04776.1 - 0.00037 20.9 0.0 0.87 10.4 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDN04776.1 - 0.00085 19.0 0.0 0.35 10.8 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDN04776.1 - 0.0015 19.2 8.0 0.22 12.4 0.0 4.6 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDN04776.1 - 0.0051 16.8 6.6 0.15 12.2 0.0 4.8 6 0 0 6 6 5 1 Tetratricopeptide repeat Tcf25 PF04910.14 EDN04776.1 - 0.075 12.1 0.1 0.071 12.2 0.1 1.2 1 0 0 1 1 1 0 Transcriptional repressor TCF25 TPR_10 PF13374.6 EDN04776.1 - 0.32 10.9 1.9 53 3.9 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDN04776.1 - 0.53 11.1 15.4 3.1 8.7 0.1 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_20 PF14561.6 EDN04776.1 - 0.93 9.9 5.9 0.93 9.9 0.1 3.5 3 2 2 5 5 5 0 Tetratricopeptide repeat AA_permease PF00324.21 EDN04778.1 - 1.3e-123 413.1 34.0 1.6e-123 412.8 34.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDN04778.1 - 6.1e-34 117.6 37.3 8.2e-34 117.2 37.3 1.0 1 0 0 1 1 1 1 Amino acid permease RRF_GI PF12614.8 EDN04779.1 - 0.066 13.4 0.3 0.39 10.9 0.1 2.0 2 0 0 2 2 2 0 Ribosome recycling factor FTA4 PF13093.6 EDN04780.1 - 2.2e-51 174.6 6.5 9.3e-29 100.8 0.0 2.0 1 1 1 2 2 2 2 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 TcdA_TcdB PF12919.7 EDN04780.1 - 0.011 15.0 0.1 0.012 14.9 0.1 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain HAD_2 PF13419.6 EDN04781.1 - 4.4e-05 23.6 0.0 6.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN04781.1 - 0.019 15.2 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ribosomal_L5e PF17144.4 EDN04782.1 - 1.1e-80 269.4 0.4 1.6e-80 268.8 0.4 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EDN04782.1 - 7.2e-35 119.8 6.3 7.2e-35 119.8 6.3 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 EDN04782.1 - 0.078 13.4 0.1 0.078 13.4 0.1 1.7 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DUF3135 PF11333.8 EDN04783.1 - 0.26 11.5 3.9 0.3 11.4 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3135) ABC_membrane_2 PF06472.15 EDN04784.1 - 2.4e-103 345.2 0.6 3.7e-103 344.6 0.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDN04784.1 - 1.1e-08 35.7 0.0 2e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDN04784.1 - 4.6e-05 23.4 0.0 0.00015 21.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Glyco_transf_22 PF03901.17 EDN04784.1 - 0.0025 17.1 0.5 0.0042 16.4 0.5 1.3 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family AAA_23 PF13476.6 EDN04784.1 - 0.0068 16.9 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDN04784.1 - 0.058 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EDN04784.1 - 0.07 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EDN04784.1 - 0.14 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RuvB_N PF05496.12 EDN04784.1 - 0.17 11.7 0.0 1.2 8.8 0.0 2.3 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_15 PF13175.6 EDN04784.1 - 0.27 10.9 0.0 0.45 10.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Phosphorylase PF00343.20 EDN04785.1 - 2e-291 968.5 0.0 2.9e-291 968.0 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase 4HBT PF03061.22 EDN04786.1 - 1e-08 35.4 0.1 1.8e-08 34.6 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EDN04786.1 - 0.00027 21.3 0.0 0.00036 20.9 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF2808 PF10989.8 EDN04786.1 - 0.033 14.2 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) Glyco_hydro_47 PF01532.20 EDN04787.1 - 3.4e-133 444.9 0.1 4.2e-133 444.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Avl9 PF09794.9 EDN04788.1 - 3.3e-104 348.6 0.0 9.1e-55 185.9 0.0 2.1 1 1 1 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EDN04788.1 - 5e-05 23.2 0.0 9.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EDN04788.1 - 0.028 14.9 0.0 0.028 14.9 0.0 2.3 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2347 PF09804.9 EDN04788.1 - 0.056 13.0 1.1 0.83 9.2 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2347) Pkinase PF00069.25 EDN04789.1 - 3e-67 226.8 0.0 3.9e-67 226.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN04789.1 - 6.2e-32 110.9 0.0 8.1e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN04789.1 - 1.2e-05 24.5 0.1 1.7e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDN04789.1 - 0.00015 21.2 0.1 0.00049 19.5 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDN04789.1 - 0.00059 19.2 0.0 0.042 13.2 0.0 2.2 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EDN04789.1 - 0.00086 19.3 0.0 0.0026 17.7 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDN04789.1 - 0.016 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDN04789.1 - 0.044 13.4 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN04790.1 - 1.2e-16 61.4 0.1 1.7e-16 60.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EDN04790.1 - 2.5e-05 23.3 0.3 0.0067 15.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EDN04790.1 - 3.7e-05 23.4 0.0 6.2e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EDN04790.1 - 0.00035 19.9 0.0 0.00065 19.0 0.0 1.5 1 1 0 1 1 1 1 Fructosamine kinase HBD PF18534.1 EDN04790.1 - 0.004 17.2 0.0 0.094 12.9 0.0 2.3 2 0 0 2 2 2 1 Helical bundle domain Pkinase PF00069.25 EDN04790.1 - 0.029 13.7 0.1 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain WD40 PF00400.32 EDN04791.1 - 4.9e-52 172.7 18.3 3.1e-08 34.1 0.4 8.5 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN04791.1 - 4.5e-13 49.3 0.1 0.00018 21.7 0.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN04791.1 - 1.3e-09 37.3 2.1 0.00014 20.7 0.0 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EDN04791.1 - 0.00055 18.8 0.0 0.25 10.0 0.0 2.8 3 0 0 3 3 3 2 Nup133 N terminal like G-alpha PF00503.20 EDN04792.1 - 1e-22 80.8 0.0 1.1e-22 80.7 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit zf-met PF12874.7 EDN04793.1 - 5.2e-23 80.7 28.1 1.7e-09 37.7 0.2 5.6 6 0 0 6 6 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDN04793.1 - 2.1e-19 69.3 24.8 2.7e-08 33.9 0.2 5.4 6 0 0 6 6 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDN04793.1 - 8.3e-19 66.7 20.8 0.017 16.0 0.2 7.1 6 1 1 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN04793.1 - 1.1e-16 60.3 24.0 0.016 15.7 0.4 6.6 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EDN04793.1 - 4.8e-12 46.1 22.7 0.008 16.5 0.9 6.0 2 2 4 6 6 6 4 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EDN04793.1 - 4.3e-07 29.8 19.0 0.033 14.2 0.4 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EDN04793.1 - 2e-06 27.4 13.4 1.6 8.5 0.0 6.1 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 EDN04793.1 - 0.00026 21.3 22.0 0.28 11.7 0.2 6.2 6 0 0 6 6 6 2 Zinc-finger double domain zf-DBF PF07535.12 EDN04793.1 - 0.0016 18.5 18.0 0.87 9.8 0.1 5.4 4 2 1 5 5 5 1 DBF zinc finger zf-C2H2_9 PF16293.5 EDN04793.1 - 0.0021 17.8 15.8 6.7 6.6 0.2 5.8 3 1 3 6 6 6 2 C2H2 type zinc-finger (1 copy) zf-C2HC_2 PF13913.6 EDN04793.1 - 0.0024 17.7 20.6 0.15 12.0 0.5 5.7 6 0 0 6 6 6 2 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 EDN04793.1 - 0.035 14.2 16.5 0.43 10.7 1.8 4.2 3 1 1 4 4 4 0 Zinc ribbon domain zf_ZIC PF18366.1 EDN04793.1 - 0.15 12.2 6.9 2.9 8.1 0.0 3.8 3 1 1 4 4 4 0 Zic proteins zinc finger domain Rad50_zn_hook PF04423.14 EDN04793.1 - 0.27 11.1 5.2 8.9 6.2 0.0 3.5 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-C2H2_3rep PF18868.1 EDN04793.1 - 0.58 10.9 11.8 0.099 13.3 1.9 2.8 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 EDN04793.1 - 0.98 9.5 18.1 0.78 9.8 0.1 4.8 2 1 2 4 4 4 0 BED zinc finger C1_4 PF07975.12 EDN04793.1 - 5.3 7.4 19.8 11 6.4 1.9 4.2 2 1 3 5 5 5 0 TFIIH C1-like domain Cullin PF00888.22 EDN04794.1 - 7.1e-159 530.3 3.6 1e-79 268.8 0.0 2.2 1 1 1 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 EDN04794.1 - 6.3e-27 93.4 2.5 2.1e-26 91.8 2.5 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain CCSMST1 PF15013.6 EDN04795.1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.4 1 1 0 1 1 1 0 CCSMST1 family MARVEL PF01284.23 EDN04796.1 - 0.0018 18.3 1.7 0.0031 17.5 1.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain FtsK_4TM PF13491.6 EDN04796.1 - 0.037 13.7 0.3 0.15 11.7 0.2 1.8 2 0 0 2 2 2 0 4TM region of DNA translocase FtsK/SpoIIIE Mit_KHE1 PF10173.9 EDN04797.1 - 1e-61 208.4 1.0 1e-61 208.4 1.0 1.4 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related End3 PF12761.7 EDN04798.1 - 6.1e-71 238.7 0.1 7.6e-71 238.4 0.1 1.1 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EDN04798.1 - 2.6e-37 127.0 0.2 5.7e-37 125.8 0.2 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EDN04798.1 - 6.1e-08 31.7 0.3 1.5e-07 30.4 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EDN04798.1 - 8.6e-07 29.3 0.3 4.3e-06 27.1 0.0 2.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EDN04798.1 - 7.7e-05 22.3 0.2 0.00032 20.4 0.2 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 EDN04798.1 - 0.0021 17.9 0.1 0.0044 16.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EDN04798.1 - 0.0021 17.5 0.6 0.0082 15.6 0.2 2.1 2 0 0 2 2 2 1 EF hand SlyX PF04102.12 EDN04798.1 - 0.33 11.6 2.5 11 6.7 0.0 2.8 2 1 0 2 2 2 0 SlyX Spc24 PF08286.11 EDN04798.1 - 0.6 10.4 2.8 9.5 6.5 0.1 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Spc7 PF08317.11 EDN04798.1 - 2.3 7.0 11.7 0.53 9.1 6.0 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF641 PF04859.12 EDN04798.1 - 2.5 8.4 5.3 8.2 6.8 2.4 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF16 PF01519.16 EDN04798.1 - 3 8.4 4.9 1.2 9.7 2.2 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.12 EDN04798.1 - 4.3 7.4 9.1 2.1 8.4 2.4 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein SNF2_N PF00176.23 EDN04799.1 - 9.9e-62 208.7 0.0 2.1e-61 207.6 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN04799.1 - 2.1e-21 76.3 0.8 2e-20 73.2 0.0 3.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN04799.1 - 2.7e-07 30.7 0.1 9e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDN04799.1 - 1.4e-06 27.7 0.0 3.3e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EDN04799.1 - 0.0011 18.2 1.2 0.039 13.1 0.0 3.2 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 BEX PF04538.12 EDN04800.1 - 0.28 11.8 2.9 0.44 11.2 1.4 2.1 2 0 0 2 2 2 0 Brain expressed X-linked like family DSPc PF00782.20 EDN04801.1 - 9e-10 38.5 0.0 5.6e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EDN04801.1 - 0.0017 18.6 0.0 0.0029 17.9 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain zf-C2H2 PF00096.26 EDN04803.1 - 1.1e-07 32.0 16.1 0.0014 19.0 0.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EDN04803.1 - 2.7e-05 24.4 1.5 4.1e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Aberrant zinc-finger Miff PF05644.11 EDN04803.1 - 0.01 15.5 0.5 0.013 15.1 0.5 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff zf-C2H2_4 PF13894.6 EDN04803.1 - 0.051 14.4 11.4 5 8.2 0.2 3.9 3 1 0 3 3 3 0 C2H2-type zinc finger FAM76 PF16046.5 EDN04803.1 - 0.058 12.8 0.2 0.058 12.8 0.2 1.8 2 0 0 2 2 2 0 FAM76 protein Transpos_assoc PF13963.6 EDN04803.1 - 0.13 12.5 3.8 0.36 11.2 0.0 2.5 1 1 0 2 2 2 0 Transposase-associated domain ZapB PF06005.12 EDN04803.1 - 0.31 11.5 3.9 0.32 11.5 1.2 2.1 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 EDN04803.1 - 0.37 10.6 1.6 0.47 10.3 0.5 1.6 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 EDN04803.1 - 0.69 10.6 3.4 1.4 9.6 1.3 2.4 3 0 0 3 3 3 0 SlyX A_deaminase PF00962.22 EDN04806.1 - 3.2e-27 95.7 0.0 3.7e-27 95.5 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF1771 PF08590.10 EDN04807.1 - 3e-22 78.8 9.1 3e-22 78.8 9.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EDN04807.1 - 2.3e-11 43.9 0.3 6.5e-11 42.4 0.3 1.8 1 0 0 1 1 1 1 Smr domain DUF4407 PF14362.6 EDN04807.1 - 0.29 10.5 1.6 0.41 9.9 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Connexin43 PF03508.13 EDN04807.1 - 0.35 10.5 2.6 0.31 10.6 0.5 2.0 2 0 0 2 2 2 0 Gap junction alpha-1 protein (Cx43) Beta_elim_lyase PF01212.21 EDN04808.1 - 1.1e-78 264.5 0.0 1.4e-78 264.1 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDN04808.1 - 0.00061 19.2 0.3 0.046 13.0 0.0 2.1 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EDN04808.1 - 0.00077 18.1 0.0 0.0014 17.2 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PIN_12 PF16289.5 EDN04808.1 - 0.058 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 PIN domain polyprenyl_synt PF00348.17 EDN04809.1 - 2.5e-65 220.1 0.0 3.1e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Sugar_tr PF00083.24 EDN04810.1 - 2.4e-86 290.4 17.5 2.9e-86 290.1 17.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN04810.1 - 3.5e-14 52.5 32.7 1.7e-09 37.1 15.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily CDC14 PF08045.11 EDN04811.1 - 1.1e-129 431.6 0.0 1.2e-129 431.4 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component DDHD PF02862.17 EDN04813.1 - 0.16 12.1 8.9 0.17 12.1 8.9 1.0 1 0 0 1 1 1 0 DDHD domain IPP-2 PF04979.14 EDN04813.1 - 0.21 12.3 13.1 0.26 12.0 13.1 1.1 1 0 0 1 1 1 0 Protein phosphatase inhibitor 2 (IPP-2) EOS1 PF12326.8 EDN04813.1 - 0.83 9.6 5.7 0.88 9.5 5.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein Folate_carrier PF01770.18 EDN04813.1 - 1.3 7.7 8.5 1.3 7.7 8.5 1.0 1 0 0 1 1 1 0 Reduced folate carrier DUF1764 PF08576.10 EDN04813.1 - 1.4 9.9 10.3 1.7 9.6 10.3 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) SelP_N PF04592.14 EDN04813.1 - 3.6 6.9 15.2 4 6.8 15.2 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Connexin PF00029.19 EDN04813.1 - 4.8 6.9 8.5 5.5 6.7 8.5 1.1 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 EDN04813.1 - 5 6.0 6.3 5.2 5.9 6.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 EDN04813.1 - 6.4 5.7 8.1 6.3 5.7 8.1 1.0 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 EDN04813.1 - 8.1 5.6 7.7 8 5.6 7.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter HTH_29 PF13551.6 EDN04816.1 - 0.055 13.5 0.0 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 Winged helix-turn helix DDE_Tnp_1_7 PF13843.6 EDN04817.1 - 1.8e-15 57.1 1.1 7.1e-07 28.8 0.3 2.1 1 1 1 2 2 2 2 Transposase IS4 Tubulin PF00091.25 EDN04818.1 - 2.5e-44 151.8 0.8 1.8e-34 119.6 0.1 2.4 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDN04818.1 - 8.6e-40 135.8 0.5 1.9e-39 134.7 0.1 1.8 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EDN04818.1 - 1.3e-06 28.7 0.0 3.2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain HSP9_HSP12 PF04119.12 EDN04819.1 - 0.0001 22.6 4.2 0.0002 21.7 4.3 1.5 1 1 0 1 1 1 1 Heat shock protein 9/12 Ipi1_N PF12333.8 EDN04820.1 - 5.4e-26 91.2 0.5 5.9e-25 87.8 0.0 2.6 2 1 1 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation EH_Signature PF15611.6 EDN04820.1 - 0.038 13.4 0.0 0.41 10.0 0.0 2.0 1 1 1 2 2 2 0 EH_Signature domain CLASP_N PF12348.8 EDN04820.1 - 0.056 13.0 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 CLASP N terminal Pyrid_oxidase_2 PF13883.6 EDN04822.1 - 2.8e-33 115.3 0.0 4e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase cIII PF08134.11 EDN04822.1 - 0.045 13.5 0.2 0.093 12.5 0.2 1.5 1 0 0 1 1 1 0 cIII protein family Cyclin PF08613.11 EDN04823.1 - 2.4e-05 24.8 0.0 2.4e-05 24.8 0.0 1.9 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EDN04823.1 - 0.0056 16.4 0.1 0.012 15.4 0.1 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain APH PF01636.23 EDN04826.1 - 0.0023 17.9 0.1 0.025 14.5 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN04826.1 - 0.023 14.3 0.0 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TetR_C_8 PF14278.6 EDN04826.1 - 0.13 12.4 0.1 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region LBP_BPI_CETP_C PF02886.17 EDN04827.1 - 0.0086 15.5 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain FMO-like PF00743.19 EDN04829.1 - 1.8e-81 274.2 0.0 1.2e-42 146.1 0.0 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDN04829.1 - 9.8e-10 38.2 0.0 0.028 13.7 0.0 3.6 3 1 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN04829.1 - 4.1e-07 29.5 0.0 0.019 14.2 0.0 3.2 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN04829.1 - 5.1e-06 26.6 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EDN04829.1 - 1.1e-05 25.5 0.6 0.03 14.3 0.0 3.2 3 1 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 EDN04829.1 - 0.00034 20.3 0.1 0.51 9.9 0.1 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EDN04829.1 - 0.003 16.3 0.2 0.036 12.8 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EDN04829.1 - 0.031 14.9 0.1 11 6.7 0.0 3.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN04829.1 - 0.034 13.4 0.1 0.064 12.5 0.1 1.4 1 0 0 1 1 1 0 Thi4 family K_oxygenase PF13434.6 EDN04829.1 - 0.17 11.0 0.0 15 4.6 0.0 2.6 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EDN04829.1 - 0.18 11.0 0.1 0.99 8.6 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain Lyase_1 PF00206.20 EDN04831.1 - 7e-103 344.3 0.0 1.2e-102 343.5 0.0 1.3 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EDN04831.1 - 7e-21 74.4 0.1 2.1e-20 72.9 0.1 1.9 1 0 0 1 1 1 1 Fumarase C C-terminus DDE_1 PF03184.19 EDN04832.1 - 4.2e-10 39.6 0.0 5.3e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN04832.1 - 0.0021 17.8 0.0 0.049 13.4 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease Lge1 PF11488.8 EDN04833.1 - 1.5 9.1 9.3 2 8.7 1.9 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF3435 PF11917.8 EDN04835.1 - 1.2e-149 498.9 8.7 2.3e-148 494.6 8.7 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) She9_MDM33 PF05546.11 EDN04835.1 - 0.052 13.4 3.7 0.15 11.8 3.7 1.8 1 0 0 1 1 1 0 She9 / Mdm33 family LemA PF04011.12 EDN04835.1 - 0.12 12.2 2.5 0.3 10.9 0.9 2.3 3 0 0 3 3 3 0 LemA family OmpH PF03938.14 EDN04835.1 - 3.7 7.9 9.7 14 6.0 4.3 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Pkinase PF00069.25 EDN04837.1 - 1.2e-16 60.9 0.0 7.5e-11 41.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN04837.1 - 1.1e-06 28.1 0.2 1e-05 24.9 0.2 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PP1c_bdg PF10488.9 EDN04840.1 - 0.024 14.1 0.3 0.033 13.7 0.3 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region Ycf34 PF10718.9 EDN04840.1 - 0.053 14.2 0.1 0.11 13.1 0.1 1.6 1 0 0 1 1 1 0 Hypothetical chloroplast protein Ycf34 APH PF01636.23 EDN04842.1 - 1.9e-07 31.2 0.1 1.9e-07 31.2 0.1 1.0 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN04842.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase Myb_DNA-binding PF00249.31 EDN04843.1 - 0.052 13.7 0.1 0.17 12.1 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain CEP63 PF17045.5 EDN04846.1 - 0.0095 15.9 7.0 0.015 15.2 7.0 1.2 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa SPX PF03105.19 EDN04846.1 - 0.19 11.6 25.6 0.016 15.1 8.8 2.1 2 0 0 2 2 2 0 SPX domain Col_cuticle_N PF01484.17 EDN04846.1 - 0.21 11.7 0.7 0.51 10.4 0.1 2.0 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain Spo12 PF05032.12 EDN04847.1 - 1.4e-15 56.9 0.2 3.6e-15 55.6 0.2 1.8 1 0 0 1 1 1 1 Spo12 family Acyl-CoA_dh_1 PF00441.24 EDN04848.1 - 2.5e-29 102.4 1.3 4.7e-29 101.5 1.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDN04848.1 - 4.5e-20 71.6 0.0 8.2e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EDN04848.1 - 4.6e-16 59.5 0.1 1e-15 58.3 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EDN04848.1 - 2e-13 50.8 5.1 4.4e-13 49.7 2.3 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain EST1_DNA_bind PF10373.9 EDN04849.1 - 1.7e-49 168.8 4.0 1.8e-49 168.8 0.2 2.6 3 1 0 3 3 3 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EDN04849.1 - 4.1e-12 46.9 0.2 1.4e-11 45.1 0.2 2.0 1 0 0 1 1 1 1 Telomerase activating protein Est1 PfkB PF00294.24 EDN04850.1 - 6.9e-66 222.6 0.2 8.6e-66 222.3 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDN04850.1 - 0.0006 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF1770 PF08589.10 EDN04851.1 - 3.6e-26 92.0 1.0 4.5e-26 91.7 1.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) WHIM1 PF15612.6 EDN04852.1 - 4.2e-06 26.1 0.3 1.1e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 YL1 PF05764.13 EDN04852.1 - 0.088 12.9 4.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 YL1 nuclear protein Ribosomal_L2_C PF03947.18 EDN04853.1 - 5.2e-41 139.8 5.8 9.4e-41 139.0 5.8 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDN04853.1 - 6.3e-13 48.5 0.2 1.6e-12 47.2 0.2 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain APH PF01636.23 EDN04854.1 - 2.5e-10 40.7 0.0 1.1e-09 38.6 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EDN04855.1 - 0.00083 18.8 0.0 0.00083 18.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Ada_Zn_binding PF02805.16 EDN04856.1 - 2.3e-30 104.4 6.3 4.7e-30 103.4 6.3 1.5 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 EDN04856.1 - 8.1e-08 32.2 0.0 2.3e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EDN04856.1 - 0.00034 20.8 0.0 0.0008 19.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Fil_haemagg_2 PF13332.6 EDN04856.1 - 0.089 12.9 1.7 0.26 11.4 1.7 1.7 1 0 0 1 1 1 0 Hemagglutinin repeat DEAD PF00270.29 EDN04857.1 - 3e-09 36.9 0.0 4.3e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2759 PF10958.8 EDN04858.1 - 0.05 13.3 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) Borealin PF10512.9 EDN04859.1 - 0.072 13.1 0.0 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 Cell division cycle-associated protein 8 Myb_DNA-binding PF00249.31 EDN04860.1 - 1.1e-11 44.7 1.3 2.1e-11 43.8 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN04860.1 - 2e-06 27.9 0.4 3.8e-06 27.1 0.1 1.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain DUF3435 PF11917.8 EDN04861.1 - 1.4e-145 485.5 0.4 1.8e-145 485.0 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Pkinase_fungal PF17667.1 EDN04862.1 - 9e-47 159.7 0.0 1.1e-46 159.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN04862.1 - 0.001 18.5 0.0 0.0015 18.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DDE_Tnp_1_7 PF13843.6 EDN04864.1 - 5.8e-63 213.3 0.6 2.5e-36 125.7 0.0 2.2 2 0 0 2 2 2 2 Transposase IS4 FAP PF07174.11 EDN04864.1 - 0.23 10.9 13.2 0.38 10.2 13.2 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DDE_1 PF03184.19 EDN04865.1 - 2.6e-23 82.6 0.0 1.5e-22 80.1 0.0 2.2 2 1 0 2 2 2 1 DDE superfamily endonuclease DUF3716 PF12511.8 EDN04865.1 - 8.8e-13 48.1 6.0 1.8e-12 47.1 6.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) HTH_Tnp_Tc5 PF03221.16 EDN04865.1 - 6.1e-10 39.0 0.0 1.5e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN04865.1 - 9.6e-05 22.0 0.3 0.0002 21.0 0.3 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_31 PF13560.6 EDN04865.1 - 0.076 13.4 0.1 0.49 10.8 0.1 2.3 1 1 0 1 1 1 0 Helix-turn-helix domain Phenol_hyd_sub PF06099.11 EDN04865.1 - 0.18 11.8 0.1 0.41 10.7 0.1 1.6 1 0 0 1 1 1 0 Phenol hydroxylase subunit BCS1_N PF08740.11 EDN04866.1 - 3.8e-30 105.3 0.0 6.1e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN04866.1 - 1.1e-19 71.1 0.0 4.7e-19 69.1 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN04866.1 - 0.00022 21.6 0.0 0.00052 20.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN04866.1 - 0.032 13.1 0.0 0.055 12.3 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EDN04866.1 - 0.044 13.8 0.0 0.16 12.0 0.0 2.0 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDN04866.1 - 0.051 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN04866.1 - 0.064 13.0 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EDN04866.1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN04866.1 - 0.11 13.1 0.1 2.8 8.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EDN04866.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 KaiC Aa_trans PF01490.18 EDN04867.1 - 3.1e-39 134.8 36.3 3.8e-39 134.6 36.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein HELP PF03451.14 EDN04867.1 - 0.065 13.1 0.4 0.17 11.7 0.2 1.7 1 1 0 1 1 1 0 HELP motif HlyE PF06109.13 EDN04867.1 - 0.73 9.1 3.8 1 8.6 0.8 2.1 2 0 0 2 2 2 0 Haemolysin E (HlyE) Methyltransf_23 PF13489.6 EDN04868.1 - 1.2e-19 70.8 0.0 1.6e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04868.1 - 1.4e-08 35.4 0.0 3.6e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN04868.1 - 4e-06 26.7 0.0 0.078 12.8 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDN04868.1 - 7.6e-06 26.5 0.0 1.6e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN04868.1 - 4.1e-05 24.3 0.0 0.00029 21.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EDN04868.1 - 0.0028 17.8 0.0 0.0065 16.6 0.0 1.6 3 0 0 3 3 3 1 FtsJ-like methyltransferase FlxA PF14282.6 EDN04870.1 - 2.5 8.1 15.3 0.31 11.1 5.1 2.4 2 0 0 2 2 2 0 FlxA-like protein MerR-DNA-bind PF09278.11 EDN04870.1 - 8.9 6.9 11.6 0.34 11.5 2.2 3.3 3 0 0 3 3 3 0 MerR, DNA binding RVT_1 PF00078.27 EDN04871.1 - 2.6e-16 59.8 0.1 3.8e-14 52.7 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN04871.1 - 0.016 15.0 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Integrase_H2C2 PF17921.1 EDN04872.1 - 3.5e-20 71.9 0.3 1.1e-19 70.2 0.3 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN04872.1 - 9.3e-15 54.3 2.5 2.5e-14 52.9 2.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN04872.1 - 2.3e-12 47.2 0.0 5.5e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN04872.1 - 0.0011 19.1 0.0 0.0025 18.0 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN04872.1 - 0.081 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 DUF3435 PF11917.8 EDN04873.1 - 1.6e-35 122.9 0.0 5.1e-35 121.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) HAUS-augmin3 PF14932.6 EDN04874.1 - 3.6e-05 23.5 1.3 4.5e-05 23.2 1.3 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 EDN04874.1 - 6.1e-05 23.2 0.7 7.7e-05 22.9 0.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus zf-C3HC4_3 PF13920.6 EDN04874.1 - 7.8e-05 22.5 10.2 0.00011 22.0 10.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DegS PF05384.11 EDN04874.1 - 0.00016 21.2 2.3 0.00021 20.8 2.3 1.1 1 0 0 1 1 1 1 Sensor protein DegS zf-C3HC4 PF00097.25 EDN04874.1 - 0.00032 20.5 8.2 0.00063 19.6 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4200 PF13863.6 EDN04874.1 - 0.0015 18.9 5.6 0.0022 18.4 5.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Troponin PF00992.20 EDN04874.1 - 0.0015 18.8 4.4 0.002 18.4 4.4 1.1 1 0 0 1 1 1 1 Troponin Lebercilin PF15619.6 EDN04874.1 - 0.0051 16.5 2.6 0.0063 16.2 2.6 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 EDN04874.1 - 0.0056 16.9 0.5 0.0076 16.4 0.5 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EDN04874.1 - 0.0062 17.0 1.8 0.0077 16.7 1.8 1.1 1 0 0 1 1 1 1 Fez1 DUF4407 PF14362.6 EDN04874.1 - 0.0077 15.6 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) zf-RING_5 PF14634.6 EDN04874.1 - 0.0078 16.1 8.2 0.014 15.4 8.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Interferon PF00143.19 EDN04874.1 - 0.01 16.0 0.1 0.013 15.7 0.1 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain zf-C3HC4_2 PF13923.6 EDN04874.1 - 0.01 15.7 8.9 0.022 14.6 8.9 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Macoilin PF09726.9 EDN04874.1 - 0.012 14.2 2.9 0.015 13.9 2.9 1.0 1 0 0 1 1 1 0 Macoilin family DivIC PF04977.15 EDN04874.1 - 0.013 15.2 2.1 0.021 14.6 2.1 1.4 1 0 0 1 1 1 0 Septum formation initiator GAS PF13851.6 EDN04874.1 - 0.014 14.7 2.0 0.02 14.3 2.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EDN04874.1 - 0.015 15.7 1.6 1.2 9.6 0.4 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 EDN04874.1 - 0.021 14.9 3.0 0.028 14.5 3.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF848 PF05852.11 EDN04874.1 - 0.03 14.5 1.1 0.04 14.0 1.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) bZIP_1 PF00170.21 EDN04874.1 - 0.033 14.3 3.8 0.1 12.7 3.8 1.8 1 1 0 1 1 1 0 bZIP transcription factor DUF4164 PF13747.6 EDN04874.1 - 0.045 14.0 5.0 0.066 13.5 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) CENP-Q PF13094.6 EDN04874.1 - 0.045 14.0 2.0 0.052 13.7 2.0 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF641 PF04859.12 EDN04874.1 - 0.062 13.6 1.2 0.082 13.2 1.2 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Exonuc_VII_L PF02601.15 EDN04874.1 - 0.062 12.9 0.2 0.075 12.6 0.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Metal_resist PF13801.6 EDN04874.1 - 0.063 13.5 2.3 0.086 13.0 2.3 1.1 1 0 0 1 1 1 0 Heavy-metal resistance DUF1192 PF06698.11 EDN04874.1 - 0.077 13.1 2.3 0.14 12.2 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Trimer_CC PF08954.11 EDN04874.1 - 0.078 12.5 5.7 0.15 11.7 5.7 1.4 1 0 0 1 1 1 0 Trimerisation motif TRAUB PF08164.12 EDN04874.1 - 0.098 13.2 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal BLOC1_2 PF10046.9 EDN04874.1 - 0.11 12.8 1.5 0.15 12.4 1.5 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2730 PF10805.8 EDN04874.1 - 0.12 12.5 0.8 0.21 11.7 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) TMF_TATA_bd PF12325.8 EDN04874.1 - 0.18 12.1 5.3 0.48 10.7 5.3 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding zf-RING_2 PF13639.6 EDN04874.1 - 2.2 8.7 13.1 3.8 7.9 13.1 1.4 1 0 0 1 1 1 0 Ring finger domain Helo_like_N PF17111.5 EDN04875.1 - 1.8e-31 109.2 8.0 6.2e-21 74.7 1.3 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins DUF16 PF01519.16 EDN04875.1 - 0.0047 17.4 6.5 0.31 11.5 1.2 2.7 2 1 0 2 2 2 2 Protein of unknown function DUF16 HWE_HK PF07536.14 EDN04875.1 - 0.018 15.7 3.5 0.028 15.1 1.7 2.2 1 1 1 2 2 2 0 HWE histidine kinase DUF3502 PF12010.8 EDN04875.1 - 0.02 15.6 0.3 6 7.5 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3502) PIN_8 PF18476.1 EDN04875.1 - 0.034 14.0 7.7 1.3 8.8 2.2 2.1 1 1 1 2 2 2 0 PIN like domain GldM_N PF12081.8 EDN04875.1 - 0.047 13.8 2.2 6.1 6.9 0.2 2.3 2 0 0 2 2 2 0 GldM N-terminal domain Myc-LZ PF02344.15 EDN04875.1 - 0.13 12.3 1.7 0.42 10.7 1.7 1.9 1 0 0 1 1 1 0 Myc leucine zipper domain MICSWaP PF17018.5 EDN04875.1 - 0.14 11.7 2.6 0.49 9.9 0.2 2.1 2 0 0 2 2 2 0 Spore wall protein DUF1640 PF07798.11 EDN04875.1 - 0.14 12.2 8.2 0.21 11.6 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) DUF1845 PF08900.11 EDN04875.1 - 0.15 11.8 3.9 7.4 6.3 0.7 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF1845) YabA PF06156.13 EDN04875.1 - 0.19 12.4 8.0 0.32 11.7 1.7 2.3 2 0 0 2 2 2 0 Initiation control protein YabA Syntaxin PF00804.25 EDN04875.1 - 0.25 11.0 7.3 0.11 12.1 1.6 2.3 2 1 0 2 2 2 0 Syntaxin ACCA PF03255.14 EDN04875.1 - 0.39 10.6 7.1 1.5 8.7 1.1 2.3 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ING PF12998.7 EDN04875.1 - 0.63 10.7 6.0 0.16 12.5 0.8 2.5 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF3391 PF11871.8 EDN04875.1 - 0.71 10.4 6.0 14 6.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Syntaxin-6_N PF09177.11 EDN04875.1 - 1.7 9.3 12.6 28 5.3 4.5 3.5 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Uso1_p115_C PF04871.13 EDN04875.1 - 2.5 8.5 8.7 6.7 7.1 3.9 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Myb_DNA-binding PF00249.31 EDN04877.1 - 7.1e-14 51.7 0.3 6e-12 45.6 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN04877.1 - 1.3e-06 28.5 0.2 1.1e-05 25.6 0.1 2.3 1 1 1 2 2 2 1 Myb-like DNA-binding domain AGOG PF09171.10 EDN04877.1 - 0.037 13.3 0.1 0.051 12.9 0.1 1.2 1 0 0 1 1 1 0 N-glycosylase/DNA lyase BCS1_N PF08740.11 EDN04878.1 - 1.2e-34 119.9 0.1 2.1e-34 119.1 0.1 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN04878.1 - 1e-19 71.3 0.0 3.8e-19 69.4 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN04878.1 - 3.6e-05 24.2 0.1 0.00011 22.7 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN04878.1 - 0.056 12.3 0.0 0.097 11.5 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EDN04878.1 - 0.074 13.1 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDN04878.1 - 0.075 12.7 0.0 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDN04878.1 - 0.084 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDN04878.1 - 0.098 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 KaiC RuvB_N PF05496.12 EDN04878.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Bac_export_2 PF01312.19 EDN04878.1 - 0.17 11.0 0.2 0.27 10.4 0.2 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Pkinase_fungal PF17667.1 EDN04881.1 - 5.3e-127 424.0 0.0 6.7e-127 423.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Caskin-Pro-rich PF16907.5 EDN04881.1 - 0.028 14.9 5.4 3.9 8.1 0.1 2.6 2 0 0 2 2 2 0 Proline rich region of Caskin proteins MauJ PF17419.2 EDN04881.1 - 0.1 12.0 0.1 0.49 9.8 0.0 1.9 2 0 0 2 2 2 0 Methylamine utilization protein MauJ BTB PF00651.31 EDN04882.1 - 0.00079 19.6 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Chromo PF00385.24 EDN04883.1 - 5.5e-06 26.2 0.2 1.1e-05 25.2 0.2 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain BAR PF03114.18 EDN04884.1 - 3.5e-16 59.6 0.4 3.8e-16 59.5 0.4 1.0 1 0 0 1 1 1 1 BAR domain Bromodomain PF00439.25 EDN04885.1 - 4.2e-28 97.2 0.8 3.3e-26 91.2 0.5 2.4 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.6 EDN04885.1 - 2.6e-14 53.6 2.1 2.6e-14 53.6 2.1 2.8 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex FRD2 PF03197.13 EDN04885.1 - 0.37 11.1 1.8 3.2 8.1 0.2 2.4 2 0 0 2 2 2 0 Bacteriophage FRD2 protein Apc15p PF05841.11 EDN04885.1 - 1 10.1 7.6 0.13 13.1 1.7 2.2 2 0 0 2 2 2 0 Apc15p protein CoA_binding PF02629.19 EDN04886.1 - 2.5e-26 92.2 0.2 3e-26 91.9 0.2 1.1 1 0 0 1 1 1 1 CoA binding domain CoA_binding_2 PF13380.6 EDN04886.1 - 0.0011 19.4 0.1 0.0017 18.8 0.1 1.3 1 0 0 1 1 1 1 CoA binding domain Radical_SAM_C PF16199.5 EDN04887.1 - 1e-32 112.0 0.1 3.1e-32 110.4 0.0 1.9 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EDN04887.1 - 2.4e-19 70.3 0.0 5.8e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily His_biosynth PF00977.21 EDN04888.1 - 1.1e-28 100.3 0.0 6.3e-28 97.8 0.0 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein Imm74 PF15603.6 EDN04889.1 - 0.089 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 74 OAS1_C PF10421.9 EDN04889.1 - 0.14 11.7 0.1 0.16 11.4 0.1 1.1 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus STE PF02200.16 EDN04890.1 - 1.7e-37 128.2 0.1 3.3e-37 127.3 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EDN04890.1 - 1.4e-11 44.2 10.7 6.7e-07 29.4 0.9 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN04890.1 - 1.5e-08 34.8 8.4 0.00017 22.1 0.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDN04890.1 - 2.5e-08 34.0 3.6 2.5e-08 34.0 3.6 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDN04890.1 - 0.00014 21.7 4.8 0.00025 20.9 0.2 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger NOA36 PF06524.12 EDN04890.1 - 0.00032 20.1 6.8 0.00052 19.4 6.8 1.2 1 0 0 1 1 1 1 NOA36 protein zf-C2H2_jaz PF12171.8 EDN04890.1 - 0.0027 18.0 0.1 0.085 13.2 0.0 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Rtf2 PF04641.12 EDN04890.1 - 0.028 13.8 1.6 0.056 12.8 1.6 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger FYDLN_acid PF09538.10 EDN04890.1 - 0.04 14.6 2.6 0.12 13.1 2.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.6 EDN04890.1 - 0.053 13.4 5.7 0.074 13.0 0.4 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-TRAF PF02176.18 EDN04890.1 - 0.097 13.4 2.4 0.18 12.5 2.4 1.4 1 0 0 1 1 1 0 TRAF-type zinc finger zinc_ribbon_9 PF14369.6 EDN04890.1 - 0.1 12.8 0.3 0.27 11.5 0.3 1.7 1 0 0 1 1 1 0 zinc-ribbon zf-Di19 PF05605.12 EDN04890.1 - 0.19 12.1 3.4 0.2 12.0 0.3 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Plasmodium_Vir PF05795.11 EDN04890.1 - 5 6.4 11.5 0.55 9.6 4.6 2.3 2 1 1 3 3 3 0 Plasmodium vivax Vir protein zf-H2C2_5 PF13909.6 EDN04890.1 - 6.2 6.7 11.3 11 5.8 0.5 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Helo_like_N PF17111.5 EDN04893.1 - 1.2e-26 93.4 9.9 4.6e-21 75.1 1.3 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins Takusan PF04822.13 EDN04893.1 - 0.08 12.8 3.1 0.15 12.0 0.4 2.6 1 1 2 3 3 3 0 Takusan RPAP2_Rtr1 PF04181.13 EDN04893.1 - 0.17 12.2 5.0 1.7 9.0 0.5 2.4 1 1 1 2 2 2 0 Rtr1/RPAP2 family ING PF12998.7 EDN04893.1 - 0.23 12.0 3.9 0.25 11.9 1.7 2.1 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Exonuc_VII_L PF02601.15 EDN04893.1 - 0.31 10.6 7.9 12 5.4 8.2 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit PIN_8 PF18476.1 EDN04893.1 - 0.59 9.9 6.2 2.1 8.2 5.5 1.8 1 1 0 1 1 1 0 PIN like domain Salp15 PF12115.8 EDN04893.1 - 3.4 8.1 5.7 81 3.7 5.7 2.3 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation APH PF01636.23 EDN04895.1 - 2.7e-08 34.0 0.1 3e-07 30.6 0.2 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family DAN PF03045.15 EDN04896.1 - 0.00063 19.8 1.5 4.1 7.5 0.0 3.0 1 1 2 3 3 3 3 DAN domain CtsR PF05848.11 EDN04896.1 - 0.0024 17.8 4.6 4.7 7.2 0.2 3.3 1 1 2 3 3 3 3 CtsR N-terminal HTH domain Atthog PF18800.1 EDN04896.1 - 0.037 13.9 1.1 0.3 11.0 1.0 2.1 1 1 0 1 1 1 0 Attenuator of Hedgehog CFC PF09443.10 EDN04896.1 - 3.2 7.7 11.4 12 5.8 0.3 3.9 4 0 0 4 4 4 0 Cripto_Frl-1_Cryptic (CFC) MFS_2 PF13347.6 EDN04897.1 - 2e-08 33.2 1.8 2e-08 33.2 1.8 1.7 2 0 0 2 2 2 1 MFS/sugar transport protein PUCC PF03209.15 EDN04897.1 - 0.069 12.1 4.3 0.43 9.5 0.2 2.3 2 0 0 2 2 2 0 PUCC protein DNA_pol_phi PF04931.13 EDN04897.1 - 0.09 10.9 4.9 0.12 10.4 4.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi MSP1_C PF07462.11 EDN04897.1 - 0.55 8.9 2.2 0.75 8.4 2.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus TFIIA PF03153.13 EDN04897.1 - 1.1 9.2 7.5 1.5 8.7 7.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Astro_capsid_p PF12226.8 EDN04897.1 - 8.6 5.4 10.4 2.4 7.2 7.5 1.4 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Na_H_Exchanger PF00999.21 EDN04898.1 - 2.5e-64 217.5 37.8 3.5e-64 217.0 37.8 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family ADH_zinc_N PF00107.26 EDN04899.1 - 4.9e-21 75.1 0.3 6.8e-21 74.6 0.3 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN04899.1 - 4.8e-06 26.4 0.0 8.1e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDN04899.1 - 0.0014 19.7 0.1 0.0021 19.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDN04899.1 - 0.05 12.9 0.3 0.076 12.3 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDN04899.1 - 0.063 12.6 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_32 PF13679.6 EDN04899.1 - 0.19 11.7 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.25 EDN04899.1 - 0.2 11.1 1.0 0.32 10.4 0.2 1.7 2 0 0 2 2 2 0 short chain dehydrogenase APH PF01636.23 EDN04900.1 - 8.7e-12 45.5 0.0 4.1e-11 43.3 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EDN04900.1 - 0.021 13.7 0.1 0.24 10.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) EcKinase PF02958.20 EDN04900.1 - 0.13 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Chromo PF00385.24 EDN04902.1 - 2.1e-09 37.1 0.3 0.0018 18.1 0.3 3.7 2 2 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Cid2 PF09774.9 EDN04902.1 - 0.082 13.3 0.1 15 6.0 0.0 2.4 2 0 0 2 2 2 0 Caffeine-induced death protein 2 p450 PF00067.22 EDN04903.1 - 4.2e-24 85.1 1.3 2.2e-13 49.8 0.1 2.3 2 0 0 2 2 2 2 Cytochrome P450 DBINO PF13892.6 EDN04904.1 - 3.2e-24 85.8 13.4 3.2e-24 85.8 13.4 4.6 4 1 1 5 5 5 2 DNA-binding domain AAA PF00004.29 EDN04906.1 - 9.7e-12 45.5 0.2 4.7e-11 43.2 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) U79_P34 PF03064.16 EDN04907.1 - 0.28 10.5 2.2 0.44 9.9 2.2 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 TFIIE_beta PF02186.15 EDN04909.1 - 0.11 12.8 1.6 1.9 8.9 0.0 2.9 3 0 0 3 3 3 0 TFIIE beta subunit core domain zf-C2H2_10 PF16588.5 EDN04909.1 - 0.24 11.2 3.7 0.47 10.2 3.7 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC PF00098.23 EDN04909.1 - 0.94 9.7 6.1 1.6 9.0 6.1 1.3 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH PF17917.1 EDN04910.1 - 3.1e-34 117.4 0.3 1e-33 115.7 0.0 2.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN04910.1 - 4.3e-32 110.1 0.0 1.2e-31 108.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN04910.1 - 5.4e-32 111.1 0.0 9e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN04910.1 - 6e-20 71.1 0.3 1.5e-19 69.9 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EDN04910.1 - 0.0014 18.8 0.0 0.0032 17.7 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger DNA_pol_viral_C PF00336.18 EDN04910.1 - 0.15 11.5 0.0 8.6 5.7 0.0 2.5 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain RRM_1 PF00076.22 EDN04912.1 - 5.8e-51 170.2 0.0 3.7e-21 74.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN04912.1 - 7e-06 25.6 0.0 7.7e-05 22.3 0.0 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.10 EDN04912.1 - 0.00018 21.5 0.0 0.11 12.6 0.0 2.5 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_8 PF11835.8 EDN04912.1 - 0.00028 21.0 0.0 0.17 12.1 0.0 2.5 2 0 0 2 2 2 2 RRM-like domain RRM_7 PF16367.5 EDN04912.1 - 0.00074 19.6 0.0 0.85 9.8 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EDN04912.1 - 0.0031 17.5 0.1 2.5 8.1 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EDN04912.1 - 0.0034 17.2 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif Acetyltransf_10 PF13673.7 EDN04912.1 - 0.041 13.8 0.0 0.08 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Limkain-b1 PF11608.8 EDN04912.1 - 0.079 13.0 0.1 9.7 6.3 0.1 3.3 3 1 0 3 3 3 0 Limkain b1 RRM_3 PF08777.11 EDN04912.1 - 0.16 12.0 0.0 2.3 8.3 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif OrsD PF12013.8 EDN04914.1 - 6.6e-38 129.7 5.0 6.6e-38 129.7 5.0 2.1 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN04914.1 - 0.016 15.0 3.5 0.24 11.2 1.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF4298 PF14131.6 EDN04914.1 - 0.045 13.7 2.0 5.3 7.1 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Ribonuc_red_lgC PF02867.15 EDN04916.1 - 3.6e-116 388.8 0.0 5.1e-114 381.7 0.0 2.0 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain YppG PF14179.6 EDN04919.1 - 7.7 7.3 14.7 0.38 11.5 7.4 2.4 4 0 0 4 4 4 0 YppG-like protein DUF4746 PF15928.5 EDN04920.1 - 0.007 15.8 8.0 0.007 15.8 8.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4746) FancD2 PF14631.6 EDN04920.1 - 0.023 12.1 0.7 0.031 11.7 0.7 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease E7 PF00527.18 EDN04920.1 - 0.086 13.0 4.4 0.28 11.4 4.4 1.8 1 0 0 1 1 1 0 E7 protein, Early protein CDC37_C PF08564.10 EDN04920.1 - 2.5 8.3 13.7 0.69 10.1 0.2 2.6 2 0 0 2 2 2 0 Cdc37 C terminal domain Paf1 PF03985.13 EDN04920.1 - 3.3 6.6 17.6 0.69 8.8 13.0 1.9 2 0 0 2 2 2 0 Paf1 DUF913 PF06025.12 EDN04920.1 - 5.9 5.8 6.3 0.32 9.9 0.9 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Helicase_C PF00271.31 EDN04922.1 - 1e-12 48.4 0.0 2.8e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain REV1_C PF16727.5 EDN04922.1 - 0.095 13.1 0.2 0.28 11.6 0.2 1.8 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain OrsD PF12013.8 EDN04925.1 - 3e-19 69.5 1.0 1.1e-18 67.7 0.1 2.2 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_10 PF16588.5 EDN04928.1 - 0.0077 15.9 3.0 0.014 15.1 3.0 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger Retrotran_gag_3 PF14244.6 EDN04928.1 - 0.031 14.1 0.1 0.067 13.0 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN04928.1 - 0.087 12.5 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Phage_min_cap2 PF06152.11 EDN04928.1 - 0.15 10.9 1.8 0.25 10.2 1.8 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 OrsD PF12013.8 EDN04935.1 - 2.4e-05 24.8 0.2 2.4e-05 24.8 0.2 2.6 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EDN04938.1 - 3e-19 69.5 1.0 1.1e-18 67.7 0.1 2.2 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D Babuvirus_MP PF07234.11 EDN04939.1 - 0.075 13.2 0.0 23 5.2 0.0 2.8 3 0 0 3 3 3 0 Movement and RNA silencing protein RMI2 PF16100.5 EDN04939.1 - 0.1 12.4 1.5 26 4.6 0.1 3.0 2 1 1 3 3 3 0 RecQ-mediated genome instability protein 2 Tudor_FRX1 PF18336.1 EDN04939.1 - 0.92 9.5 2.8 33 4.5 0.3 2.7 2 0 0 2 2 2 0 Fragile X mental retardation Tudor domain Helicase_C PF00271.31 EDN04941.1 - 6.9e-15 55.4 0.1 1.8e-14 54.0 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN04941.1 - 1.8e-13 50.7 0.0 6.1e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN04941.1 - 4.2e-07 30.1 0.3 2.3e-06 27.7 0.0 2.5 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EDN04941.1 - 0.054 12.2 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN04944.1 - 3.7e-27 94.9 0.1 6.6e-13 49.0 0.1 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 EDN04944.1 - 1.2e-10 41.5 0.1 8.5e-09 35.4 0.0 3.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase OrsD PF12013.8 EDN04944.1 - 1.9e-09 37.9 0.9 1.9e-09 37.9 0.9 3.0 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D FOXP-CC PF16159.5 EDN04944.1 - 0.03 14.9 4.4 0.19 12.4 0.2 3.5 3 0 0 3 3 3 0 FOXP coiled-coil domain T4SS-DNA_transf PF02534.14 EDN04944.1 - 0.057 12.2 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer DUF573 PF04504.14 EDN04948.1 - 4.2e-05 24.1 0.2 0.0005 20.7 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN04948.1 - 0.00058 20.0 0.2 0.0016 18.6 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN04948.1 - 0.064 13.5 0.3 0.2 11.9 0.3 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN04948.1 - 0.087 13.2 1.8 0.75 10.2 1.8 2.2 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain SLD5_C PF16922.5 EDN04948.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus Helicase_C PF00271.31 EDN04949.1 - 3.9e-15 56.1 0.1 9.5e-15 54.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Nexin_C PF08628.12 EDN04952.1 - 0.01 16.4 0.3 0.014 16.0 0.3 1.1 1 0 0 1 1 1 0 Sorting nexin C terminal FlxA PF14282.6 EDN04953.1 - 4.4 7.4 16.4 0.52 10.3 6.2 2.4 2 0 0 2 2 2 0 FlxA-like protein RT_RNaseH PF17917.1 EDN04954.1 - 5e-37 126.4 0.0 1.1e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN04954.1 - 1.8e-32 111.3 0.0 5.4e-32 109.8 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN04954.1 - 6e-20 71.1 0.3 1.5e-19 69.8 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 EDN04954.1 - 1.6e-15 57.2 0.1 1.1e-13 51.2 0.0 2.4 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN04954.1 - 2.6e-12 47.0 0.0 7.8e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN04954.1 - 0.0016 18.7 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger CFEM PF05730.11 EDN04957.1 - 4.5e-13 49.1 6.4 6.9e-13 48.5 6.4 1.3 1 0 0 1 1 1 1 CFEM domain Sas10_Utp3 PF04000.15 EDN04960.1 - 3e-16 59.8 0.3 7.6e-16 58.5 0.0 1.8 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DNA_pol_phi PF04931.13 EDN04960.1 - 4.8 5.2 11.0 7.2 4.6 11.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Methyltransf_23 PF13489.6 EDN04961.1 - 9.1e-22 77.6 0.0 1.5e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN04961.1 - 1.3e-05 25.8 0.0 0.00022 21.9 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN04961.1 - 0.00047 20.0 0.0 0.0043 16.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN04961.1 - 0.0037 17.9 0.0 0.0077 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 EDN04961.1 - 0.21 10.9 0.0 0.94 8.8 0.0 1.8 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G 5_nucleotid_C PF02872.18 EDN04962.1 - 8.4e-41 139.8 0.0 1.8e-40 138.8 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EDN04962.1 - 0.00029 21.4 0.1 0.00052 20.6 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase His_Phos_1 PF00300.22 EDN04963.1 - 2.9e-05 23.8 2.7 0.27 10.9 0.0 3.8 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) UQ_con PF00179.26 EDN04964.1 - 1.3e-51 173.9 0.0 1.5e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN04964.1 - 0.00068 19.3 0.0 0.00075 19.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDN04964.1 - 0.083 13.2 0.0 0.13 12.5 0.0 1.4 1 1 0 1 1 1 0 RWD domain Kinesin PF00225.23 EDN04965.1 - 1.6e-111 372.5 0.1 4.3e-111 371.0 0.1 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDN04965.1 - 1.7e-25 89.7 0.0 6.3e-25 87.9 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding CALCOCO1 PF07888.11 EDN04965.1 - 0.0026 16.7 45.9 0.04 12.8 25.4 2.3 2 0 0 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like ATG16 PF08614.11 EDN04965.1 - 0.0037 17.5 16.3 0.0037 17.5 16.3 3.7 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) MLTR_LBD PF17765.1 EDN04965.1 - 0.012 15.8 0.1 0.041 14.0 0.1 1.9 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain FAD-SLDH PF12318.8 EDN04965.1 - 0.4 10.7 3.9 2 8.4 0.1 3.3 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase HALZ PF02183.18 EDN04965.1 - 1.3 9.3 20.1 2.4 8.4 0.7 5.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF2407_C PF13373.6 EDN04965.1 - 4.7 7.4 12.0 3.7 7.7 0.2 2.9 3 0 0 3 3 3 0 DUF2407 C-terminal domain YojJ PF10372.9 EDN04965.1 - 4.8 7.3 8.2 4.7 7.4 0.9 3.1 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Peptidase_C1_2 PF03051.15 EDN04966.1 - 2.4e-148 494.6 0.0 3e-148 494.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EDN04966.1 - 4.1e-06 27.0 0.1 0.035 14.2 0.3 2.3 2 0 0 2 2 2 2 Papain family cysteine protease DUF4272 PF14094.6 EDN04966.1 - 0.088 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) Thiolase_N PF00108.23 EDN04967.1 - 7.6e-91 304.1 0.2 1e-90 303.6 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN04967.1 - 2.2e-37 127.4 0.5 2.2e-37 127.4 0.5 1.9 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDN04967.1 - 1.5e-05 24.7 0.3 0.0008 19.1 0.2 2.6 1 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EDN04967.1 - 0.037 13.9 3.6 8 6.4 0.0 3.4 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Cation_efflux PF01545.21 EDN04968.1 - 6e-47 160.0 13.1 6e-47 160.0 13.1 2.5 2 1 0 2 2 2 1 Cation efflux family DUF996 PF06195.13 EDN04968.1 - 0.6 10.4 0.0 0.6 10.4 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF996) DUF2649 PF10854.8 EDN04968.1 - 1.2 9.5 3.0 1.1 9.7 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2649) Glyco_trans_1_4 PF13692.6 EDN04970.1 - 5.8e-07 30.0 0.0 8.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EDN04970.1 - 0.011 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF1910 PF08928.10 EDN04970.1 - 0.052 13.5 0.0 0.55 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Otopetrin PF03189.13 EDN04971.1 - 0.025 13.4 1.2 0.044 12.6 0.4 1.6 2 0 0 2 2 2 0 Otopetrin TFIIIC_delta PF12657.7 EDN04972.1 - 9.1e-28 97.4 4.5 3.1e-19 69.6 1.1 2.6 2 1 1 3 3 3 2 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EDN04972.1 - 1.7e-20 72.9 0.1 2.6e-09 36.9 0.0 2.5 2 0 0 2 2 2 2 Putative zinc-finger of transcription factor IIIC complex zf-RRN7 PF11781.8 EDN04972.1 - 0.47 10.2 3.3 14 5.4 0.6 2.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Mito_carr PF00153.27 EDN04973.1 - 2.7e-54 181.1 3.4 1.4e-18 66.6 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein UQ_con PF00179.26 EDN04975.1 - 4.7e-43 146.2 0.0 5.3e-43 146.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EMP70 PF02990.16 EDN04977.1 - 1.3e-197 657.6 3.3 1.6e-197 657.3 3.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 BiPBP_C PF06832.12 EDN04977.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family DUF3920 PF13058.6 EDN04977.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3920) Glyco_hydro_16 PF00722.21 EDN04977.1 - 0.2 11.1 0.7 0.45 10.0 0.1 1.8 2 0 0 2 2 2 0 Glycosyl hydrolases family 16 EF-hand_7 PF13499.6 EDN04978.1 - 1.1e-24 86.7 2.2 8.2e-16 58.2 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDN04978.1 - 1.7e-24 83.5 12.0 2.7e-08 32.8 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EDN04978.1 - 3e-24 82.8 2.6 2.5e-05 23.9 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EDN04978.1 - 1.8e-16 58.8 8.7 0.00012 21.4 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EDN04978.1 - 5.4e-15 55.0 11.9 1.6e-05 24.7 1.3 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EDN04978.1 - 1.1e-08 34.9 4.7 0.0021 18.0 0.2 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EDN04978.1 - 0.00019 21.7 0.6 0.014 15.7 0.1 2.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_10 PF14788.6 EDN04978.1 - 0.011 15.6 0.6 2 8.4 0.1 3.3 3 0 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.9 EDN04978.1 - 0.013 15.8 0.4 1.3 9.4 0.2 2.9 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 EDN04978.1 - 0.14 12.0 1.6 13 5.6 0.0 3.1 3 1 1 4 4 4 0 Caleosin related protein Med4 PF10018.9 EDN04979.1 - 7.7e-34 117.1 0.0 1.3e-33 116.3 0.0 1.4 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 MFS_1 PF07690.16 EDN04980.1 - 1.7e-15 56.8 7.4 1.7e-15 56.8 7.4 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDN04982.1 - 4.7e-23 81.7 24.8 2.2e-21 76.2 20.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily F-box-like PF12937.7 EDN04983.1 - 0.00026 20.8 0.8 0.0026 17.6 0.0 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EDN04983.1 - 0.00027 20.7 0.0 0.00064 19.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain AMP-binding PF00501.28 EDN04984.1 - 9.7e-87 291.3 0.0 1.4e-86 290.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN04984.1 - 0.0013 19.7 0.4 0.0033 18.4 0.4 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_hydro_92 PF07971.12 EDN04986.1 - 2.1e-141 472.0 0.0 2.5e-141 471.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EDN04986.1 - 7.5e-60 202.8 0.3 1e-59 202.3 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain RabGAP-TBC PF00566.18 EDN04988.1 - 1.5e-19 70.5 0.0 8.2e-19 68.1 0.0 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain YabA PF06156.13 EDN04988.1 - 0.039 14.6 8.1 2.6 8.7 0.1 2.8 2 0 0 2 2 2 0 Initiation control protein YabA Peptidase_S46 PF10459.9 EDN04988.1 - 0.2 10.3 9.8 0.28 9.8 9.8 1.2 1 0 0 1 1 1 0 Peptidase S46 PI3K_P85_iSH2 PF16454.5 EDN04988.1 - 0.95 9.0 18.9 58 3.2 18.9 2.4 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Spc7 PF08317.11 EDN04988.1 - 1.7 7.4 27.4 0.37 9.6 13.5 2.9 2 1 1 3 3 3 0 Spc7 kinetochore protein EMP24_GP25L PF01105.24 EDN04988.1 - 3.3 7.6 8.5 2.5 8.0 0.8 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Exonuc_VII_L PF02601.15 EDN04988.1 - 4.7 6.7 11.1 11 5.5 11.1 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 EDN04988.1 - 7.3 5.4 5.4 11 4.8 5.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YebO PF13974.6 EDN04988.1 - 7.4 6.7 6.8 2.8 8.1 3.0 2.3 2 0 0 2 2 2 0 YebO-like protein DNA_topoisoIV PF00521.20 EDN04990.1 - 7.8e-139 463.2 0.2 1.7e-138 462.2 0.0 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EDN04990.1 - 2.3e-49 167.0 5.9 6e-49 165.6 5.9 1.8 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EDN04990.1 - 3.8e-26 91.6 4.2 9.2e-26 90.4 4.2 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EDN04990.1 - 1e-14 55.0 0.1 4.3e-14 53.0 0.0 2.2 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EDN04990.1 - 5e-07 29.9 0.0 4.2e-06 26.9 0.0 2.7 2 0 0 2 2 2 1 Toprim domain Reticulon PF02453.17 EDN04992.1 - 2.4e-25 89.3 3.2 4e-25 88.6 3.2 1.3 1 0 0 1 1 1 1 Reticulon Cytochrome-c551 PF10643.9 EDN04992.1 - 0.0008 19.0 0.1 0.0015 18.1 0.1 1.4 1 0 0 1 1 1 1 Photosystem P840 reaction-centre cytochrome c-551 Microvir_H PF04687.12 EDN04992.1 - 0.051 13.0 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Acyl-CoA_dh_1 PF00441.24 EDN04993.1 - 2.4e-31 109.0 1.8 6.2e-31 107.6 1.8 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDN04993.1 - 2.2e-23 83.1 0.2 4.9e-23 81.9 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EDN04993.1 - 3.1e-15 56.6 1.2 3.1e-15 56.6 1.2 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDN04993.1 - 1.2e-11 44.6 0.0 2.6e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain INCENP_ARK-bind PF03941.15 EDN04994.1 - 2.7e-16 59.3 1.5 9.6e-16 57.5 0.6 2.5 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region APH PF01636.23 EDN04995.1 - 3.6e-07 30.4 0.0 4.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3624 PF12292.8 EDN04995.1 - 0.24 11.8 5.2 0.51 10.8 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) PDZ_1 PF12812.7 EDN04997.1 - 3.8e-53 177.4 0.1 1.8e-35 120.8 0.0 2.8 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 EDN04997.1 - 6.6e-23 82.3 0.9 1.8e-21 77.6 0.1 2.9 3 0 0 3 3 3 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 EDN04997.1 - 3.5e-15 55.6 0.6 4e-08 33.0 0.3 4.2 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 EDN04997.1 - 1.5e-13 50.8 0.3 3.2e-05 24.1 0.0 4.2 5 0 0 5 5 5 3 PDZ domain PDZ PF00595.24 EDN04997.1 - 3.1e-11 43.5 0.0 2.3e-05 24.7 0.0 3.6 3 0 0 3 3 3 3 PDZ domain Trypsin PF00089.26 EDN04997.1 - 7.1e-05 22.7 0.0 0.00023 21.1 0.0 1.8 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 EDN04997.1 - 0.00014 21.8 0.2 0.4 10.7 0.1 3.7 3 0 0 3 3 3 2 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 EDN04997.1 - 0.073 11.7 0.3 0.13 10.8 0.1 1.4 2 0 0 2 2 2 0 Peptidase S46 DUF31 PF01732.16 EDN04997.1 - 0.13 11.8 0.2 0.22 11.0 0.2 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) SSXT PF05030.12 EDN04998.1 - 0.00015 21.3 0.0 0.025 14.2 0.0 3.1 4 0 0 4 4 4 2 SSXT protein (N-terminal region) POX PF07526.11 EDN04998.1 - 3 8.4 9.4 14 6.3 0.0 2.5 2 1 1 3 3 3 0 Associated with HOX Pox_T4_N PF04491.12 EDN04999.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus TPR_19 PF14559.6 EDN04999.1 - 0.018 15.5 0.1 0.046 14.2 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDN04999.1 - 0.025 14.7 0.5 23 5.4 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDN04999.1 - 0.028 14.3 5.5 4.9 7.1 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat FSH1 PF03959.13 EDN05000.1 - 6e-25 88.2 0.0 1.2e-24 87.2 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EDN05000.1 - 1.9e-06 28.7 0.2 7.8e-06 26.7 0.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN05000.1 - 0.06 13.0 0.1 1.3 8.6 0.0 2.6 4 0 0 4 4 4 0 alpha/beta hydrolase fold DLH PF01738.18 EDN05000.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.5 2 0 0 2 2 2 0 Dienelactone hydrolase family DDE_1 PF03184.19 EDN05001.1 - 8.4e-23 80.9 0.0 1.6e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN05001.1 - 1.4e-05 24.9 0.0 0.00089 19.0 0.0 3.1 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05001.1 - 0.0011 18.9 0.2 0.0055 16.7 0.0 2.4 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN05001.1 - 0.025 14.3 0.5 0.025 14.3 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN05001.1 - 0.042 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) DS PF01916.17 EDN05002.1 - 4e-128 426.7 0.1 4.7e-128 426.5 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase HMMR_N PF15905.5 EDN05003.1 - 0.0021 17.6 2.2 0.0026 17.3 2.2 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 EDN05003.1 - 0.0025 16.8 1.9 0.0032 16.4 1.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Fib_alpha PF08702.10 EDN05003.1 - 0.0052 17.0 2.8 0.39 10.9 1.6 2.1 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EDN05003.1 - 0.0054 16.8 0.6 0.0082 16.2 0.6 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 EDN05003.1 - 0.0075 16.3 1.8 0.012 15.7 0.7 1.8 1 1 0 1 1 1 1 Laminin Domain II Apolipoprotein PF01442.18 EDN05003.1 - 0.0088 15.9 4.4 0.013 15.3 4.4 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EDN05003.1 - 0.011 15.8 2.8 0.066 13.3 2.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 EDN05003.1 - 0.011 15.8 0.5 0.14 12.3 0.1 2.0 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) BLOC1_2 PF10046.9 EDN05003.1 - 0.018 15.3 2.0 0.12 12.7 1.2 2.2 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAM76 PF16046.5 EDN05003.1 - 0.028 13.8 0.7 0.035 13.5 0.7 1.2 1 0 0 1 1 1 0 FAM76 protein Phage_lysis PF03245.13 EDN05003.1 - 0.035 14.2 1.7 0.035 14.2 1.7 1.7 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein DUF5082 PF16888.5 EDN05003.1 - 0.045 14.0 1.7 0.21 11.9 1.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Wtap PF17098.5 EDN05003.1 - 0.062 13.2 3.6 1.9 8.4 3.6 2.2 1 1 0 1 1 1 0 WTAP/Mum2p family DASH_Spc34 PF08657.10 EDN05003.1 - 0.14 12.0 2.3 0.15 11.9 2.3 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Val_tRNA-synt_C PF10458.9 EDN05003.1 - 0.19 12.1 6.3 0.23 11.8 0.7 2.5 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DUF16 PF01519.16 EDN05003.1 - 0.19 12.2 3.8 0.79 10.2 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 HR1 PF02185.16 EDN05003.1 - 0.32 11.2 6.7 5.5 7.2 0.8 2.4 1 1 1 2 2 2 0 Hr1 repeat Syntaxin-6_N PF09177.11 EDN05003.1 - 0.33 11.5 3.1 3.3 8.3 2.7 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal SlyX PF04102.12 EDN05003.1 - 0.35 11.5 6.6 13 6.5 3.3 2.4 1 1 1 2 2 2 0 SlyX DUF641 PF04859.12 EDN05003.1 - 0.45 10.9 4.6 2.3 8.6 0.8 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CdvA PF18822.1 EDN05003.1 - 0.48 10.3 6.9 2.8 7.8 2.4 2.3 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Remorin_C PF03763.13 EDN05003.1 - 0.57 10.1 3.6 1.4 8.9 3.6 1.7 1 1 0 1 1 1 0 Remorin, C-terminal region XhlA PF10779.9 EDN05003.1 - 0.59 10.4 3.1 4.8 7.4 0.1 2.4 2 1 0 2 2 2 0 Haemolysin XhlA CENP-F_leu_zip PF10473.9 EDN05003.1 - 0.7 9.9 10.0 13 5.8 10.0 2.1 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TolA_bind_tri PF16331.5 EDN05003.1 - 3.2 7.9 9.6 5.4 7.2 0.8 2.3 1 1 1 2 2 2 0 TolA binding protein trimerisation Spc29 PF17082.5 EDN05003.1 - 4.1 7.2 6.3 10 5.8 0.4 2.2 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF919 PF06034.11 EDN05003.1 - 6.6 6.6 7.3 15 5.5 1.9 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) PKcGMP_CC PF16808.5 EDN05003.1 - 8.8 6.3 11.4 0.93 9.4 3.6 2.9 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase peroxidase PF00141.23 EDN05004.1 - 7.7e-48 163.2 0.0 1.1e-47 162.7 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DUF1769 PF08588.10 EDN05004.1 - 0.025 14.8 0.0 0.32 11.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1769) DUF4360 PF14273.6 EDN05007.1 - 1e-47 162.3 0.5 1.2e-47 162.1 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Pyridoxal_deC PF00282.19 EDN05008.1 - 1e-81 274.6 0.0 1.3e-81 274.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDN05008.1 - 4.7e-05 22.5 0.0 8.5e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDN05008.1 - 0.012 15.0 0.0 0.028 13.7 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family HC2 PF07382.11 EDN05009.1 - 1.5e-05 25.2 29.7 0.00028 21.0 13.4 3.3 2 1 0 3 3 3 2 Histone H1-like nucleoprotein HC2 SBDS_C PF09377.10 EDN05011.1 - 4.1e-44 149.3 0.0 5.8e-44 148.8 0.0 1.2 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EDN05011.1 - 3.4e-33 113.6 0.0 6e-33 112.8 0.0 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein FAM176 PF14851.6 EDN05011.1 - 0.29 10.8 1.7 2 8.1 0.6 2.3 2 0 0 2 2 2 0 FAM176 family Med3 PF11593.8 EDN05011.1 - 0.3 10.2 11.4 0.44 9.7 11.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3246 PF11596.8 EDN05011.1 - 1.8 8.0 6.8 0.14 11.6 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) NST1 PF13945.6 EDN05011.1 - 2.1 8.4 4.8 14 5.8 0.1 2.5 3 0 0 3 3 3 0 Salt tolerance down-regulator Peptidase_S10 PF00450.22 EDN05012.1 - 3.7e-129 431.8 1.0 4.4e-129 431.6 1.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EDN05012.1 - 1.7e-12 47.9 0.0 4.4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Ribosomal_S13 PF00416.22 EDN05013.1 - 2.9e-56 189.3 4.2 3.4e-56 189.1 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EDN05013.1 - 0.018 13.8 0.1 0.023 13.5 0.1 1.2 1 1 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HNH_2 PF13391.6 EDN05015.1 - 4.5e-14 52.3 0.2 1.1e-13 51.1 0.0 1.7 2 0 0 2 2 2 1 HNH endonuclease SNF5 PF04855.12 EDN05015.1 - 0.014 15.2 0.1 0.015 15.1 0.1 1.3 1 1 0 1 1 1 0 SNF5 / SMARCB1 / INI1 GMC_oxred_N PF00732.19 EDN05016.1 - 1.4e-44 152.7 0.0 2.6e-22 79.6 0.0 2.1 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN05016.1 - 1.9e-27 96.5 0.0 4.4e-27 95.4 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EDN05016.1 - 0.00033 20.0 0.0 0.0036 16.6 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDN05016.1 - 0.0014 17.8 0.0 0.0023 17.1 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EDN05016.1 - 0.0033 17.6 0.0 0.0079 16.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDN05016.1 - 0.004 16.8 0.0 0.043 13.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDN05016.1 - 0.0043 16.2 0.0 0.23 10.5 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EDN05016.1 - 0.0057 15.9 0.1 0.016 14.5 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EDN05016.1 - 0.0081 15.4 0.0 2.4 7.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDN05016.1 - 0.11 11.2 0.0 0.23 10.1 0.0 1.5 2 0 0 2 2 2 0 HI0933-like protein Pkinase PF00069.25 EDN05017.1 - 1.5e-08 34.3 0.0 3.6e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EDN05017.1 - 0.033 13.5 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like ARHGEF5_35 PF15441.6 EDN05017.1 - 0.065 12.2 0.1 0.095 11.7 0.1 1.1 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 Pkinase_Tyr PF07714.17 EDN05017.1 - 0.071 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 EDN05018.1 - 1.7e-62 211.2 0.0 2.7e-62 210.5 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05018.1 - 2.7e-26 92.4 0.0 4.9e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN05018.1 - 0.00038 19.9 0.0 0.00069 19.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDN05018.1 - 0.012 15.0 0.6 0.021 14.2 0.6 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDN05018.1 - 0.021 14.4 0.5 0.021 14.4 0.5 1.6 2 0 0 2 2 2 0 RIO1 family Haspin_kinase PF12330.8 EDN05018.1 - 0.068 12.1 0.0 0.094 11.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDN05018.1 - 0.13 12.2 0.1 0.13 12.2 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Acetyltransf_6 PF13480.7 EDN05018.1 - 0.14 12.3 1.7 0.27 11.4 1.7 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4100 PF13352.6 EDN05018.1 - 0.32 10.7 6.3 0.5 10.1 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) HMA PF00403.26 EDN05019.1 - 4.7e-11 43.0 0.0 7.6e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EDN05019.1 - 2.3e-09 37.6 0.0 3.2e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TPR_2 PF07719.17 EDN05020.1 - 3.6e-12 45.4 5.4 0.00034 20.5 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 EDN05020.1 - 4.8e-11 42.0 6.8 0.00043 20.0 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDN05020.1 - 2e-05 24.9 0.3 14 6.6 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN05020.1 - 2.2e-05 24.3 1.9 0.061 13.6 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDN05020.1 - 3.3e-05 23.5 2.8 0.0029 17.3 0.2 3.8 2 1 2 4 4 4 1 TPR repeat TPR_12 PF13424.6 EDN05020.1 - 3.6e-05 24.0 0.5 0.025 14.8 0.0 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDN05020.1 - 0.00017 21.6 0.0 0.15 12.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat PB1 PF00564.24 EDN05020.1 - 0.00041 20.2 0.1 0.00086 19.2 0.1 1.6 1 0 0 1 1 1 1 PB1 domain TPR_7 PF13176.6 EDN05020.1 - 0.00079 19.3 0.6 0.016 15.2 0.2 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN05020.1 - 0.004 17.8 0.3 0.52 11.0 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDN05020.1 - 0.019 15.3 0.1 2.3 8.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN05020.1 - 0.069 14.0 0.0 3.1 8.8 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat Syntaxin-18_N PF10496.9 EDN05021.1 - 1.2e-14 54.4 1.4 6.8e-14 51.9 0.1 2.7 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus DUF3819 PF12842.7 EDN05021.1 - 0.012 15.6 1.7 0.016 15.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3819) SNARE PF05739.19 EDN05021.1 - 0.03 14.3 0.0 0.078 13.0 0.0 1.7 1 0 0 1 1 1 0 SNARE domain SSFA2_C PF14723.6 EDN05021.1 - 0.06 13.3 1.3 0.18 11.7 1.0 1.8 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus FAP206 PF12018.8 EDN05021.1 - 0.15 11.5 1.9 1.1 8.8 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function Acyl_transf_3 PF01757.22 EDN05022.1 - 1.2e-22 80.5 27.9 1.6e-22 80.0 27.9 1.1 1 0 0 1 1 1 1 Acyltransferase family Pkinase_fungal PF17667.1 EDN05023.1 - 5.4e-124 414.1 0.0 7e-124 413.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Aminotran_1_2 PF00155.21 EDN05024.1 - 4.7e-81 272.8 0.0 5.4e-81 272.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II zf-RING_2 PF13639.6 EDN05025.1 - 4.7e-13 49.2 4.6 8.2e-13 48.5 4.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDN05025.1 - 7.3e-10 38.4 1.3 1.3e-09 37.6 1.3 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDN05025.1 - 5e-08 32.7 5.2 9.1e-08 31.8 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN05025.1 - 1.2e-07 31.5 3.4 2.1e-07 30.7 3.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDN05025.1 - 9.5e-06 25.4 6.2 4.1e-05 23.4 5.6 2.2 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EDN05025.1 - 9.8e-06 25.8 5.9 3.5e-05 24.0 5.9 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDN05025.1 - 4.8e-05 23.2 1.8 8.3e-05 22.5 1.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EDN05025.1 - 0.00035 20.6 1.0 0.00072 19.6 1.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EDN05025.1 - 0.00056 19.7 1.8 0.001 18.9 1.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EDN05025.1 - 0.0072 16.1 3.5 0.014 15.2 3.5 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EDN05025.1 - 0.018 15.1 5.4 0.041 13.9 5.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING-like PF08746.11 EDN05025.1 - 0.17 12.2 1.5 0.3 11.4 1.5 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 EDN05025.1 - 1.3 9.2 3.6 17 5.7 3.6 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain Mucin PF01456.17 EDN05025.1 - 2.9 7.9 33.9 0.71 9.9 26.2 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein Prok-RING_1 PF14446.6 EDN05025.1 - 3.4 7.7 5.6 6.3 6.8 2.3 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 EDN05025.1 - 3.5 7.8 5.2 6.9 6.9 5.2 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING POP1 PF06978.11 EDN05026.1 - 0.18 11.8 0.8 0.23 11.4 0.8 1.2 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 MS_channel PF00924.18 EDN05027.1 - 4.3e-20 72.1 1.6 9.5e-20 71.0 1.6 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_6 PF13405.6 EDN05027.1 - 0.00091 19.0 0.1 0.016 15.1 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EDN05027.1 - 0.0081 15.6 0.1 0.0081 15.6 0.1 2.2 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EDN05027.1 - 0.0084 16.5 0.3 0.033 14.7 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EDN05027.1 - 0.054 13.0 0.0 0.35 10.4 0.0 2.4 2 0 0 2 2 2 0 EF hand DUF1189 PF06691.11 EDN05027.1 - 5.2 6.6 9.8 5.8 6.4 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) Mgm101p PF06420.12 EDN05028.1 - 3.3e-88 293.6 0.0 4.4e-88 293.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 CHASE5 PF17149.4 EDN05028.1 - 0.042 13.8 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Periplasmic sensor domain found in signal transduction proteins P33MONOX PF15302.6 EDN05028.1 - 0.25 11.0 12.2 0.39 10.4 12.2 1.3 1 0 0 1 1 1 0 P33 mono-oxygenase MSP1_C PF07462.11 EDN05028.1 - 0.49 9.0 2.2 0.61 8.7 2.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Hamartin PF04388.12 EDN05028.1 - 0.59 8.7 13.6 0.65 8.6 13.6 1.0 1 0 0 1 1 1 0 Hamartin protein BPL_N PF09825.9 EDN05029.1 - 1.8e-124 415.7 0.4 3.2e-113 378.6 0.1 2.7 2 1 1 3 3 3 2 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EDN05029.1 - 2.2e-16 59.9 0.0 5.1e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EDN05029.1 - 5e-07 29.5 0.0 1.1e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain TANGO2 PF05742.12 EDN05030.1 - 2.2e-75 254.0 0.0 2.6e-75 253.8 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 MFS_1 PF07690.16 EDN05031.1 - 6.4e-12 45.1 51.9 2.7e-09 36.4 18.1 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EDN05031.1 - 1.1e-07 30.7 22.7 1.5e-07 30.2 22.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4492 PF14899.6 EDN05031.1 - 3.1 7.8 5.9 27 4.8 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4492) TB2_DP1_HVA22 PF03134.19 EDN05032.1 - 2.2e-24 85.2 7.6 3.5e-24 84.5 7.6 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family AF-4 PF05110.13 EDN05033.1 - 0.86 7.6 13.6 0.99 7.4 13.6 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4551 PF15087.6 EDN05033.1 - 7.3 5.3 7.5 8.4 5.1 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) PBP_like_2 PF12849.7 EDN05034.1 - 1e-11 45.0 0.0 1.3e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 PBP superfamily domain GARS_A PF01071.19 EDN05035.1 - 4.7e-83 277.8 0.0 8e-83 277.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EDN05035.1 - 1.7e-33 115.3 0.1 8.7e-33 113.0 0.0 2.3 3 0 0 3 3 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EDN05035.1 - 4.8e-33 114.5 0.1 1.2e-32 113.2 0.1 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EDN05035.1 - 1.6e-25 89.2 0.3 4.1e-25 87.9 0.3 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EDN05035.1 - 5.2e-13 49.5 7.9 1.6e-12 47.9 5.1 2.8 1 1 1 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 EDN05035.1 - 2.3e-05 24.0 0.0 4.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDN05035.1 - 0.00029 20.9 0.0 0.00065 19.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EDN05035.1 - 0.0023 17.5 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 EDN05035.1 - 0.0049 16.5 0.0 0.009 15.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EDN05035.1 - 0.066 12.4 0.0 0.32 10.2 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATP-grasp_2 PF08442.10 EDN05035.1 - 0.081 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain DUF1147 PF06615.11 EDN05035.1 - 0.18 11.8 0.4 1.3 9.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) DUF5496 PF17600.2 EDN05035.1 - 0.2 11.7 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5496) Pet127 PF08634.10 EDN05036.1 - 3.3e-118 394.1 0.0 4.4e-118 393.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 LRR_6 PF13516.6 EDN05037.1 - 0.00023 21.0 7.4 1.7 8.9 0.0 7.2 8 0 0 8 8 8 2 Leucine Rich repeat Gly_transf_sug PF04488.15 EDN05038.1 - 2e-19 70.0 0.1 4e-19 69.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Peptidase_M24 PF00557.24 EDN05040.1 - 3.6e-40 137.9 0.2 5.3e-40 137.4 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3616 PF12275.8 EDN05040.1 - 0.042 13.3 0.9 0.065 12.6 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) DnaJ PF00226.31 EDN05041.1 - 1.6e-20 73.0 0.1 2.9e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Bul1_N PF04425.12 EDN05042.1 - 2.2e-07 30.0 2.3 5e-06 25.6 2.3 2.1 1 1 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.12 EDN05042.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Bul1 C terminus BORA_N PF15280.6 EDN05042.1 - 0.028 14.1 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein aurora borealis N-terminus Arrestin_N PF00339.29 EDN05042.1 - 0.079 13.0 0.3 0.25 11.4 0.1 1.9 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Usp PF00582.26 EDN05045.1 - 1.2e-22 81.0 0.1 2.9e-22 79.7 0.0 1.7 2 0 0 2 2 2 1 Universal stress protein family PPP4R2 PF09184.11 EDN05045.1 - 0.68 9.5 7.3 1.2 8.6 7.3 1.3 1 0 0 1 1 1 0 PPP4R2 Nucleo_P87 PF07267.11 EDN05045.1 - 3.1 6.6 6.2 4.8 5.9 6.2 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SNF2_N PF00176.23 EDN05048.1 - 8.9e-65 218.7 0.0 1.6e-64 217.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN05048.1 - 7.3e-19 68.1 0.0 4.1e-18 65.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN05048.1 - 8.2e-08 32.4 0.0 1.7e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIF_beta PF02270.15 EDN05048.1 - 0.0053 16.9 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain ERCC3_RAD25_C PF16203.5 EDN05048.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Pkinase PF00069.25 EDN05049.1 - 3.1e-48 164.4 0.1 1.6e-47 162.1 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05049.1 - 9.4e-22 77.5 0.0 1.8e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN05049.1 - 0.00042 20.3 2.0 0.00044 20.2 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDN05049.1 - 0.0029 17.2 0.2 0.0085 15.7 0.2 1.7 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EDN05049.1 - 0.42 10.2 2.2 0.36 10.4 0.2 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase eIF-3c_N PF05470.12 EDN05050.1 - 7e-173 576.1 29.2 2.4e-139 465.4 3.8 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EDN05050.1 - 1.5e-13 51.2 4.6 2e-12 47.5 0.0 3.8 3 0 0 3 3 3 1 PCI domain Dynactin_p22 PF07426.11 EDN05050.1 - 0.023 14.5 3.8 0.033 14.1 1.8 2.3 2 0 0 2 2 2 0 Dynactin subunit p22 DUF1385 PF07136.11 EDN05050.1 - 0.093 12.0 0.0 0.36 10.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) DUF2884 PF11101.8 EDN05050.1 - 0.31 10.5 6.8 0.86 9.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) BORCS7 PF16088.5 EDN05050.1 - 0.4 11.0 4.1 0.48 10.7 1.8 2.4 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 EAP30 PF04157.16 EDN05051.1 - 1.5e-70 237.2 0.0 1.7e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_L30_N PF08079.12 EDN05052.1 - 1.6e-27 95.5 15.7 1.6e-27 95.5 15.7 1.6 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EDN05052.1 - 5.9e-17 61.3 2.8 5.9e-17 61.3 2.8 1.8 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DNA_pol_B PF00136.21 EDN05053.1 - 8.2e-115 384.1 5.0 1.2e-114 383.6 5.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EDN05053.1 - 1.3e-68 230.4 2.0 1.3e-68 230.4 2.0 1.8 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EDN05053.1 - 3.2e-38 131.7 0.0 5.7e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EDN05053.1 - 8.3e-25 86.7 6.5 8.3e-25 86.7 6.5 2.8 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EDN05053.1 - 0.00091 18.2 0.1 0.002 17.1 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral DUF3659 PF12396.8 EDN05053.1 - 0.33 10.9 2.1 0.75 9.8 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) Phos_pyr_kin PF08543.12 EDN05054.1 - 3.7e-85 285.2 4.6 5e-85 284.8 4.6 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EDN05054.1 - 1.5e-45 155.6 0.7 5.9e-32 111.2 0.1 2.2 1 1 1 2 2 2 2 TENA/THI-4/PQQC family PfkB PF00294.24 EDN05054.1 - 7.1e-06 25.5 1.6 0.0021 17.4 0.1 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase HK PF02110.15 EDN05054.1 - 0.0011 18.4 1.4 0.019 14.3 0.2 2.3 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family Herpes_ori_bp PF02399.15 EDN05054.1 - 0.14 10.2 0.0 0.19 9.8 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein DEAD PF00270.29 EDN05055.1 - 4.9e-50 169.7 0.0 3.9e-49 166.8 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN05055.1 - 2.1e-30 105.3 0.0 7e-30 103.6 0.0 1.9 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN05055.1 - 4.7e-05 23.4 0.0 0.00035 20.6 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EDN05055.1 - 0.02 13.7 0.0 1.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 EDN05055.1 - 0.2 12.0 0.2 18 5.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF1387 PF07139.11 EDN05057.1 - 1 9.0 6.4 0.12 12.1 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) DUF3723 PF12520.8 EDN05058.1 - 2.5e-100 336.6 3.4 1.5e-78 264.7 0.8 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3723) RNase_H PF00075.24 EDN05058.1 - 4.3e-11 43.2 0.0 1.2e-10 41.7 0.0 1.8 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 EDN05058.1 - 2.4e-05 24.1 0.0 5.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase-like Bindin PF02084.15 EDN05058.1 - 0.3 11.3 0.7 6.9 6.9 2.4 2.0 2 0 0 2 2 2 0 Bindin DUF2383 PF09537.10 EDN05059.1 - 0.0028 18.0 0.0 0.0034 17.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2383) Stork_head PF10264.9 EDN05059.1 - 0.022 14.9 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain Ferritin-like PF12902.7 EDN05059.1 - 0.042 13.7 0.1 0.053 13.4 0.1 1.1 1 0 0 1 1 1 0 Ferritin-like F-box-like PF12937.7 EDN05060.1 - 2.2e-06 27.4 0.0 4.9e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN05060.1 - 2.5e-05 24.0 0.0 6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EDN05060.1 - 0.061 13.6 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 PRANC domain DUF2441 PF10386.9 EDN05060.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2441) TraD PF06412.11 EDN05060.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Conjugal transfer protein TraD Mur_ligase_M PF08245.12 EDN05061.1 - 1.9e-06 28.0 0.0 3.4e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 Mur ligase middle domain Rad9 PF04139.13 EDN05062.1 - 9.6e-55 185.7 1.2 1.1e-54 185.5 1.2 1.0 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EDN05062.1 - 8.2e-05 21.8 0.5 0.00029 20.0 0.5 1.9 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 CorA PF01544.18 EDN05062.1 - 0.0092 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein RCC1 PF00415.18 EDN05063.1 - 8.4e-39 132.0 9.7 6.9e-09 36.2 0.0 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDN05063.1 - 3.4e-18 64.9 23.6 1.8e-07 30.8 0.2 7.0 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat PPR_2 PF13041.6 EDN05064.1 - 2.5e-09 37.2 0.0 0.0012 19.0 0.0 3.5 3 1 1 4 4 4 2 PPR repeat family PPR PF01535.20 EDN05064.1 - 0.019 15.2 0.0 31 5.1 0.0 4.2 4 0 0 4 4 4 0 PPR repeat Mannitol_dh_C PF08125.13 EDN05065.1 - 2.4e-42 145.1 0.0 4.1e-42 144.4 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EDN05065.1 - 8.4e-22 77.9 0.2 3.5e-21 76.0 0.1 2.0 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.14 EDN05065.1 - 0.00055 19.6 1.8 0.00067 19.3 0.4 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EDN05065.1 - 0.00091 19.2 0.2 0.016 15.1 0.0 2.7 3 1 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EDN05065.1 - 0.018 14.3 0.1 0.034 13.4 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Latarcin PF10279.9 EDN05065.1 - 0.032 14.7 0.0 0.083 13.3 0.0 1.8 2 0 0 2 2 2 0 Latarcin precursor Pyr_redox PF00070.27 EDN05065.1 - 0.055 14.0 1.2 0.13 12.8 0.3 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF3439 PF11921.8 EDN05066.1 - 0.89 9.5 4.7 1.9 8.4 4.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SWIRM PF04433.17 EDN05067.1 - 6e-10 39.3 0.1 2.6e-09 37.3 0.0 2.0 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.31 EDN05067.1 - 1e-09 38.4 0.0 3.4e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EDN05067.1 - 7.7e-08 32.0 7.5 1.4e-07 31.2 7.5 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 EDN05067.1 - 2.1e-05 24.7 0.0 6.1e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Pkinase PF00069.25 EDN05068.1 - 2.8e-69 233.4 0.0 3.8e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05068.1 - 9e-33 113.6 0.0 1.3e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDN05068.1 - 2.6e-08 34.4 0.1 6.9e-08 33.1 0.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EDN05068.1 - 1.4e-05 24.2 0.0 2.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDN05068.1 - 0.00076 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like C2 PF00168.30 EDN05068.1 - 0.045 14.0 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 C2 domain Coatomer_WDAD PF04053.14 EDN05069.1 - 3.4e-170 566.9 0.0 7.7e-170 565.7 0.0 1.6 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EDN05069.1 - 3.3e-36 122.7 9.2 4.7e-06 27.2 0.0 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05069.1 - 1.1e-06 28.8 0.1 2.3 8.6 0.0 5.2 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN05069.1 - 0.00016 20.5 2.4 0.13 10.8 0.1 3.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EDN05069.1 - 0.023 14.8 0.0 11 6.1 0.0 4.0 2 1 2 4 4 4 0 Ciliary BBSome complex subunit 2, middle region MetallophosC PF16370.5 EDN05069.1 - 0.068 13.4 0.0 0.27 11.5 0.0 1.9 1 1 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase ETC_C1_NDUFA5 PF04716.14 EDN05070.1 - 7.2e-28 96.2 6.6 1.1e-25 89.2 0.5 2.8 3 0 0 3 3 3 2 ETC complex I subunit conserved region DUF3416 PF11896.8 EDN05070.1 - 0.033 14.5 0.7 0.38 11.0 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3416) Peripla_BP_6 PF13458.6 EDN05070.1 - 0.17 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein BAR_3 PF16746.5 EDN05070.1 - 0.26 10.9 2.6 0.14 11.8 0.8 1.5 2 0 0 2 2 2 0 BAR domain of APPL family SPAM PF02090.15 EDN05070.1 - 0.41 10.4 5.8 0.52 10.1 4.4 1.8 1 1 1 2 2 2 0 Salmonella surface presentation of antigen gene type M protein Thioredoxin PF00085.20 EDN05071.1 - 4.9e-35 119.6 0.0 7e-23 80.6 0.0 3.9 3 1 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 EDN05071.1 - 1.6e-08 34.7 0.0 0.033 14.1 0.0 4.5 4 1 1 5 5 5 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EDN05071.1 - 4.5e-05 23.9 0.5 0.21 12.0 0.1 3.9 3 1 0 3 3 3 1 Thioredoxin-like domain HyaE PF07449.11 EDN05071.1 - 0.00072 19.5 0.0 0.46 10.5 0.0 2.9 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.6 EDN05071.1 - 0.023 15.0 0.3 10 6.5 0.1 3.7 3 1 1 4 4 4 0 Thioredoxin-like Thioredoxin_7 PF13899.6 EDN05071.1 - 0.087 13.0 0.4 0.27 11.5 0.1 2.0 2 0 0 2 2 2 0 Thioredoxin-like Calsequestrin PF01216.17 EDN05071.1 - 0.091 11.8 0.1 0.17 10.9 0.1 1.3 1 0 0 1 1 1 0 Calsequestrin DUF3557 PF12078.8 EDN05071.1 - 0.092 12.7 0.1 0.64 10.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3557) Thioredoxin_3 PF13192.6 EDN05071.1 - 0.098 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin domain AhpC-TSA PF00578.21 EDN05071.1 - 0.16 11.8 0.2 0.66 9.9 0.1 2.0 1 1 1 2 2 2 0 AhpC/TSA family AA_permease_2 PF13520.6 EDN05072.1 - 6e-65 219.7 47.5 7.2e-65 219.5 47.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDN05072.1 - 2.5e-15 56.0 38.0 3.4e-15 55.6 38.0 1.1 1 0 0 1 1 1 1 Amino acid permease HTH_7 PF02796.15 EDN05073.1 - 7.7e-06 25.9 0.0 6.2e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 EDN05073.1 - 1.9e-05 24.6 0.1 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 EDN05073.1 - 2.1e-05 24.2 0.1 0.0011 18.7 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 EDN05073.1 - 5.4e-05 22.9 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_33 PF13592.6 EDN05073.1 - 0.00013 21.5 0.0 0.00048 19.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix PAX PF00292.18 EDN05073.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.4 1 1 0 1 1 1 0 'Paired box' domain Terminase_5 PF06056.12 EDN05073.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_32 PF13565.6 EDN05073.1 - 0.098 13.3 0.0 4.8 7.9 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.6 EDN05073.1 - 0.18 12.0 0.1 19 5.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain APG5 PF04106.12 EDN05074.1 - 0.037 13.6 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg5 Nucleo_P87 PF07267.11 EDN05074.1 - 0.28 10.0 2.8 0.39 9.5 2.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DDE_1 PF03184.19 EDN05075.1 - 1.5e-05 24.7 0.1 0.00028 20.6 0.0 2.6 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05075.1 - 0.059 13.4 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain ACBP PF00887.19 EDN05077.1 - 5.2e-21 74.7 0.1 6e-21 74.5 0.1 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein U-box PF04564.15 EDN05078.1 - 2.1e-23 82.2 0.1 4.2e-23 81.3 0.1 1.5 1 0 0 1 1 1 1 U-box domain TPR_2 PF07719.17 EDN05078.1 - 2.4e-09 36.6 2.6 0.0017 18.3 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDN05078.1 - 3.6e-07 29.7 3.4 4.8e-05 23.0 0.2 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDN05078.1 - 1.3e-06 27.9 0.7 3e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.6 EDN05078.1 - 1.1e-05 26.0 3.3 0.014 16.0 2.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDN05078.1 - 1.3e-05 25.6 0.1 0.00049 20.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDN05078.1 - 0.00032 20.9 0.7 0.0023 18.2 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDN05078.1 - 0.00034 21.2 1.7 0.24 12.3 0.0 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat zf-NOSIP PF15906.5 EDN05078.1 - 0.0014 18.8 0.0 0.0032 17.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein GvpG PF05120.12 EDN05078.1 - 0.007 16.4 0.9 0.014 15.4 0.9 1.5 1 0 0 1 1 1 1 Gas vesicle protein G TPR_12 PF13424.6 EDN05078.1 - 0.017 15.4 2.5 0.17 12.2 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 EDN05078.1 - 0.018 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 RING-type zinc-finger TPR_9 PF13371.6 EDN05078.1 - 0.034 14.3 0.1 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 EDN05078.1 - 0.035 14.9 1.6 0.059 14.1 1.6 1.3 1 0 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain DDE_Tnp_4 PF13359.6 EDN05080.1 - 4.4e-07 29.7 0.0 8.3e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1_7 PF13843.6 EDN05081.1 - 1.1e-28 100.5 0.0 1.4e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 DUF2407_C PF13373.6 EDN05082.1 - 1 9.5 2.9 0.71 10.1 0.6 1.8 2 0 0 2 2 2 0 DUF2407 C-terminal domain PIF1 PF05970.14 EDN05083.1 - 3.3e-22 79.2 0.0 6.2e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase TFIIA PF03153.13 EDN05083.1 - 0.0001 22.5 13.9 0.00017 21.7 13.9 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 EDN05083.1 - 0.054 12.5 14.7 0.11 11.6 14.7 1.5 1 0 0 1 1 1 0 Solute carrier family 12 DUF3435 PF11917.8 EDN05085.1 - 2.5e-29 102.4 4.1 6.2e-17 61.6 0.5 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3435) DHO_dh PF01180.21 EDN05086.1 - 6.6e-61 206.1 0.3 4.1e-52 177.2 0.0 2.0 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase PcrB PF01884.17 EDN05086.1 - 0.00079 18.9 0.6 1 8.8 0.0 2.5 3 0 0 3 3 3 2 PcrB family PDE8 PF08629.10 EDN05086.1 - 0.023 14.7 0.4 0.058 13.4 0.4 1.6 1 0 0 1 1 1 0 PDE8 phosphodiesterase FMN_dh PF01070.18 EDN05086.1 - 0.058 12.4 0.5 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Cas_Cas7 PF05107.12 EDN05086.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Cas7 BLYB PF05289.11 EDN05088.1 - 0.053 13.7 0.0 0.096 12.9 0.0 1.4 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein DUF2796 PF10986.8 EDN05090.1 - 0.21 11.5 9.0 0.26 11.2 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) PPL5 PF18168.1 EDN05090.1 - 0.44 9.8 8.5 0.53 9.5 8.5 1.1 1 0 0 1 1 1 0 Prim-pol family 5 GAGA_bind PF06217.12 EDN05090.1 - 0.6 10.3 12.2 0.73 10.1 12.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family TRAP_alpha PF03896.16 EDN05090.1 - 0.79 8.9 7.2 0.87 8.7 7.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DDHD PF02862.17 EDN05090.1 - 1.6 8.8 5.4 1.8 8.6 5.4 1.2 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 EDN05090.1 - 1.9 6.7 13.3 2.1 6.5 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Atg14 PF10186.9 EDN05090.1 - 3.2 6.7 12.9 4.5 6.3 12.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Neur_chan_memb PF02932.16 EDN05090.1 - 3.5 7.6 10.0 4.1 7.4 10.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 EDN05090.1 - 6.8 5.8 6.9 6.7 5.8 6.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EDN05090.1 - 9.4 4.9 9.2 9.6 4.8 9.2 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 EDN05090.1 - 9.7 4.9 9.0 11 4.7 9.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA PF00004.29 EDN05091.1 - 1.5e-10 41.6 0.0 2.1e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) EAR PF07897.11 EDN05091.1 - 0.086 12.5 0.1 0.23 11.1 0.1 1.7 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression zf-H2C2_2 PF13465.6 EDN05095.1 - 2.7e-05 24.4 13.8 4.3e-05 23.8 2.2 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-Di19 PF05605.12 EDN05095.1 - 0.00036 20.8 4.7 0.00065 19.9 4.7 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EDN05095.1 - 0.0011 19.6 15.9 0.017 15.9 5.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDN05095.1 - 0.018 15.3 6.1 0.077 13.3 1.2 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EDN05095.1 - 0.089 13.3 15.7 0.11 13.0 7.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-met PF12874.7 EDN05095.1 - 3.1 8.3 5.6 4.1 7.9 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Choline_kinase PF01633.20 EDN05096.1 - 0.01 15.4 0.0 0.027 14.1 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EDN05096.1 - 0.021 14.4 0.0 0.059 13.0 0.0 1.7 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN05096.1 - 0.046 13.6 0.2 0.046 13.6 0.2 3.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family CENP-Q PF13094.6 EDN05096.1 - 0.14 12.3 19.7 0.038 14.2 12.9 2.8 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit CDC45 PF02724.14 EDN05096.1 - 6.3 5.0 8.8 9.6 4.4 8.8 1.3 1 0 0 1 1 1 0 CDC45-like protein EST1_DNA_bind PF10373.9 EDN05099.1 - 0.0019 17.8 0.0 0.003 17.1 0.0 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain NINJA_B PF16136.5 EDN05099.1 - 0.038 14.4 1.2 0.097 13.1 0.4 1.9 2 0 0 2 2 2 0 Putative nuclear localisation signal NuDC PF16273.5 EDN05101.1 - 0.042 14.4 0.6 0.096 13.2 0.6 1.6 1 0 0 1 1 1 0 Nuclear distribution C domain Macoilin PF09726.9 EDN05101.1 - 0.08 11.5 6.1 0.095 11.3 6.1 1.1 1 0 0 1 1 1 0 Macoilin family TMPIT PF07851.13 EDN05101.1 - 0.092 12.0 3.0 0.15 11.3 2.7 1.6 1 1 0 1 1 1 0 TMPIT-like protein Sec34 PF04136.15 EDN05101.1 - 0.12 12.3 2.7 0.16 11.9 2.0 1.7 1 1 0 1 1 1 0 Sec34-like family Prp19 PF08606.11 EDN05101.1 - 0.39 10.7 4.2 0.29 11.1 2.0 1.9 1 1 1 2 2 2 0 Prp19/Pso4-like ZapB PF06005.12 EDN05101.1 - 3.5 8.2 8.1 1.7e+02 2.8 8.1 2.7 1 1 0 1 1 1 0 Cell division protein ZapB Patatin PF01734.22 EDN05103.1 - 1.9e-16 60.8 0.2 5.1e-16 59.5 0.0 1.8 2 0 0 2 2 2 1 Patatin-like phospholipase Prok-RING_4 PF14447.6 EDN05103.1 - 4e-05 23.4 4.0 0.00015 21.6 4.0 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDN05103.1 - 0.0021 18.0 6.9 0.0021 18.0 6.9 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Cys_rich_CPXG PF14255.6 EDN05103.1 - 0.078 12.9 1.3 0.33 10.9 0.3 2.2 2 0 0 2 2 2 0 Cysteine-rich CPXCG zf-C3HC4 PF00097.25 EDN05103.1 - 0.081 12.8 4.2 0.37 10.7 4.2 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN05103.1 - 0.17 12.3 8.5 0.55 10.6 8.5 2.0 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 EDN05103.1 - 0.22 11.6 10.5 0.063 13.3 4.7 3.0 2 1 1 3 3 3 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDN05103.1 - 1.1 9.2 14.7 0.015 15.1 6.7 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF5024 PF16427.5 EDN05104.1 - 0.07 13.5 1.6 0.12 12.7 1.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5024) CREPT PF16566.5 EDN05104.1 - 0.09 13.0 7.2 0.13 12.4 7.2 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour PET117 PF15786.5 EDN05104.1 - 0.27 11.5 3.4 0.34 11.2 2.1 1.8 1 1 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial DUF3723 PF12520.8 EDN05105.1 - 2.8e-149 498.1 0.0 3.2e-149 497.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) Pkinase PF00069.25 EDN05106.1 - 3.8e-11 42.8 0.0 5.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05106.1 - 1e-09 38.1 0.0 1.7e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NAD_binding_6 PF08030.12 EDN05108.1 - 8.1e-07 29.3 0.0 1e-06 29.0 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDN05108.1 - 9.5e-06 25.7 0.0 7.3e-05 22.8 0.0 2.4 2 1 0 2 2 2 1 FAD-binding domain MFS_3 PF05977.13 EDN05110.1 - 0.12 10.7 0.2 0.17 10.2 0.2 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector DUF3435 PF11917.8 EDN05111.1 - 2.4e-171 570.3 0.6 3.8e-171 569.6 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) NQRA_SLBB PF11973.8 EDN05112.1 - 0.091 13.4 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 NQRA C-terminal domain Integrase_H2C2 PF17921.1 EDN05113.1 - 1e-13 51.1 0.0 2e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN05113.1 - 2.6e-13 50.2 0.0 4.8e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN05113.1 - 9.8e-07 28.6 0.1 2.6e-06 27.2 0.1 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 EDN05113.1 - 0.0042 17.1 0.1 0.0085 16.2 0.1 1.5 1 0 0 1 1 1 1 Chromo shadow domain zf-H2C2 PF09337.10 EDN05113.1 - 0.022 15.0 0.0 0.062 13.5 0.0 1.8 1 0 0 1 1 1 0 H2C2 zinc finger gag_pre-integrs PF13976.6 EDN05113.1 - 0.052 13.4 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 GAG-pre-integrase domain Y_phosphatase PF00102.27 EDN05114.1 - 1.1e-41 142.9 0.0 1.6e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EDN05114.1 - 0.00041 20.5 0.0 0.00093 19.3 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 EDN05114.1 - 0.01 15.6 0.1 0.043 13.6 0.0 2.0 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EDN05114.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF2660 PF10859.8 EDN05114.1 - 0.13 12.7 0.2 3.7 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2660) KCT2 PF17818.1 EDN05114.1 - 0.14 12.2 0.4 0.33 11.0 0.4 1.6 1 0 0 1 1 1 0 Keratinocyte-associated gene product VanZ PF04892.12 EDN05115.1 - 4.8e-09 36.9 0.2 7e-09 36.4 0.2 1.2 1 0 0 1 1 1 1 VanZ like family Bromodomain PF00439.25 EDN05116.1 - 5.3e-20 71.3 1.2 4.7e-19 68.2 0.3 2.5 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.13 EDN05116.1 - 7.7e-07 29.0 0.0 2.5e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 Bromodomain associated ING PF12998.7 EDN05116.1 - 6 7.5 10.3 5.1 7.7 0.6 3.1 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding APH PF01636.23 EDN05117.1 - 4e-07 30.2 0.2 1.8e-06 28.1 0.2 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Lgl_C PF08596.10 EDN05118.1 - 2.4e-41 141.8 0.0 6.8e-41 140.3 0.0 1.7 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 EDN05118.1 - 2.2e-05 25.1 0.4 0.11 13.4 0.1 4.8 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05118.1 - 6.7e-05 23.1 0.0 3.2 8.1 0.0 4.4 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain LRV PF01816.17 EDN05118.1 - 0.15 12.5 0.0 0.52 10.8 0.0 2.0 1 0 0 1 1 1 0 Leucine rich repeat variant ASF1_hist_chap PF04729.13 EDN05119.1 - 2.1e-42 144.7 0.4 4.2e-22 78.7 0.1 2.2 1 1 1 2 2 2 2 ASF1 like histone chaperone Nop14 PF04147.12 EDN05119.1 - 0.1 10.8 26.4 0.13 10.5 26.4 1.0 1 0 0 1 1 1 0 Nop14-like family Suf PF05843.14 EDN05120.1 - 1.4e-57 195.9 20.9 4.1e-39 135.3 0.1 5.6 5 2 2 7 7 7 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDN05120.1 - 6.1e-06 26.6 0.4 0.33 11.9 0.1 4.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDN05120.1 - 0.0084 16.7 0.0 0.027 15.1 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat HAT PF02184.16 EDN05120.1 - 0.0091 15.9 0.1 0.0091 15.9 0.1 3.0 4 0 0 4 4 4 1 HAT (Half-A-TPR) repeat Piwi PF02171.17 EDN05121.1 - 2.5e-73 247.0 0.0 3.6e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EDN05121.1 - 4.1e-22 79.3 0.0 8.5e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EDN05121.1 - 3.7e-16 58.5 1.1 6.2e-16 57.8 0.1 1.9 2 0 0 2 2 2 1 Argonaute linker 1 domain PAZ PF02170.22 EDN05121.1 - 5.1e-09 36.1 0.1 9.1e-09 35.2 0.1 1.4 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EDN05121.1 - 1.6e-08 34.7 0.0 5.7e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 EDN05121.1 - 6.7e-07 29.5 0.0 1.5e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain PTAC PF06130.12 EDN05121.1 - 0.014 15.5 0.0 0.14 12.3 0.0 2.6 3 0 0 3 3 3 0 Phosphate propanoyltransferase TPP_enzyme_N PF02776.18 EDN05123.1 - 2.2e-26 92.5 0.0 3.8e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDN05123.1 - 5.7e-19 68.2 0.0 1.7e-18 66.7 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDN05123.1 - 4.8e-16 58.9 0.0 1.1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 EDN05123.1 - 0.0071 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Fungal_trans PF04082.18 EDN05124.1 - 7.5e-30 103.9 0.0 1.5e-29 102.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN05124.1 - 3.1e-11 43.2 12.6 5e-11 42.5 12.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EDN05124.1 - 0.12 12.6 0.6 0.4 10.9 0.0 2.1 2 0 0 2 2 2 0 Gal4-like dimerisation domain Keratin_2_head PF16208.5 EDN05124.1 - 0.17 12.0 13.5 0.36 11.0 13.5 1.5 1 0 0 1 1 1 0 Keratin type II head SUIM_assoc PF16619.5 EDN05124.1 - 5.6 7.1 15.1 0.8 9.8 6.2 3.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Methyltransf_23 PF13489.6 EDN05125.1 - 0.00061 19.7 0.0 0.07 13.0 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Sugar_tr PF00083.24 EDN05126.1 - 1.1e-38 133.3 10.1 1.4e-38 132.9 10.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN05126.1 - 8.5e-13 47.9 18.1 1.4e-12 47.2 18.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_5 PF05631.14 EDN05126.1 - 0.0065 15.4 0.8 0.01 14.8 0.8 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM TRI12 PF06609.13 EDN05126.1 - 0.042 12.3 2.4 0.058 11.8 2.4 1.2 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_2 PF04550.12 EDN05126.1 - 0.066 13.8 3.6 0.18 12.4 3.6 1.7 1 0 0 1 1 1 0 Phage holin family 2 MFS_1_like PF12832.7 EDN05126.1 - 0.79 8.5 6.1 1.1 8.0 6.1 1.3 1 0 0 1 1 1 0 MFS_1 like family Phage_holin_5_1 PF06946.11 EDN05126.1 - 5.4 7.5 6.1 4.7 7.6 3.9 2.0 1 1 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 Sugar_tr PF00083.24 EDN05127.1 - 3.9e-19 68.9 6.2 4e-19 68.8 6.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Collagen PF01391.18 EDN05128.1 - 0.23 11.3 1.8 0.36 10.6 1.8 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) DUF3712 PF12505.8 EDN05129.1 - 3e-06 27.5 0.2 0.00079 19.7 0.0 3.1 2 1 1 3 3 3 2 Protein of unknown function (DUF3712) Fungal_trans_2 PF11951.8 EDN05130.1 - 2.1e-06 26.8 0.0 5.1e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Sigma70_r2 PF04542.14 EDN05130.1 - 0.032 14.0 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Sigma-70 region 2 PHD PF00628.29 EDN05131.1 - 2e-08 34.0 2.6 4.4e-08 32.9 2.6 1.6 1 0 0 1 1 1 1 PHD-finger SOAR PF16533.5 EDN05131.1 - 0.28 11.2 6.6 0.6 10.1 0.5 2.7 3 0 0 3 3 3 0 STIM1 Orai1-activating region AC_N PF16214.5 EDN05131.1 - 1.1 8.4 3.5 2 7.5 3.5 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region SUIM_assoc PF16619.5 EDN05133.1 - 0.0084 16.2 2.1 0.0084 16.2 2.1 2.0 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Glyco_transf_9 PF01075.17 EDN05133.1 - 0.014 14.8 0.1 0.025 13.9 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 9 (heptosyltransferase) Spt20 PF12090.8 EDN05133.1 - 0.15 11.6 6.2 0.28 10.7 6.2 1.4 1 0 0 1 1 1 0 Spt20 family Aldolase_II PF00596.21 EDN05134.1 - 2e-45 155.0 0.8 2.5e-45 154.7 0.8 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Med31 PF05669.12 EDN05136.1 - 8.2e-31 105.9 0.0 1.1e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 SOH1 Pal1 PF08316.11 EDN05138.1 - 1.8e-47 161.6 0.5 1.8e-47 161.6 0.5 3.0 3 1 0 3 3 3 1 Pal1 cell morphology protein Xan_ur_permease PF00860.20 EDN05139.1 - 5.6e-16 58.2 31.7 6.6e-08 31.7 11.8 3.4 2 1 0 2 2 2 2 Permease family TAT_signal PF10518.9 EDN05139.1 - 2.3 8.2 6.2 0.72 9.8 0.3 3.0 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence MAGE PF01454.19 EDN05140.1 - 8.5e-60 202.1 0.0 1.1e-59 201.7 0.0 1.2 1 0 0 1 1 1 1 MAGE family DUF2997 PF11211.8 EDN05140.1 - 0.14 12.0 0.3 0.39 10.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Ank_2 PF12796.7 EDN05141.1 - 5.7e-10 39.7 0.9 0.00011 22.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN05141.1 - 3.7e-07 29.9 0.5 0.079 13.6 0.0 3.6 3 1 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EDN05141.1 - 2.1e-06 27.9 0.7 0.029 14.7 0.0 3.8 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN05141.1 - 2.4e-06 28.0 0.5 0.0055 17.3 0.2 3.5 2 2 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EDN05141.1 - 0.0092 16.4 0.2 3.6 8.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat RNA_POL_M_15KD PF02150.16 EDN05142.1 - 2.6e-06 27.2 2.7 1.4e-05 24.9 2.7 2.0 1 1 0 1 1 1 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 EDN05142.1 - 0.064 13.2 1.0 0.1 12.6 1.0 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain GTP_EFTU PF00009.27 EDN05143.1 - 1.1e-54 184.9 0.0 1.7e-54 184.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDN05143.1 - 2e-42 144.0 0.0 4.8e-42 142.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDN05143.1 - 4.6e-14 52.6 0.8 1.7e-13 50.7 0.8 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDN05143.1 - 0.0023 18.0 0.1 0.022 14.8 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EDN05143.1 - 0.039 13.9 0.6 0.039 13.9 0.6 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 AAA_29 PF13555.6 EDN05143.1 - 0.059 13.1 0.2 16 5.3 0.1 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Aim21 PF11489.8 EDN05144.1 - 5.6e-260 865.2 68.6 5.6e-260 865.2 68.6 1.7 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 DUF1765 PF08578.10 EDN05145.1 - 1.2e-43 148.5 5.0 3e-43 147.3 5.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) FSA_C PF10479.9 EDN05145.1 - 3.2 5.8 7.7 6.2 4.8 7.7 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ATP_sub_h PF10775.9 EDN05146.1 - 2.7e-23 81.7 2.5 4.2e-23 81.1 2.5 1.3 1 0 0 1 1 1 1 ATP synthase complex subunit h DUF2759 PF10958.8 EDN05147.1 - 0.064 13.0 0.3 0.16 11.7 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) TFIIB PF00382.19 EDN05148.1 - 3.5e-39 132.7 0.1 2.6e-20 72.2 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EDN05148.1 - 2e-11 43.2 0.6 2e-11 43.2 0.6 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding RB_B PF01857.20 EDN05148.1 - 0.00076 19.5 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Cyclin_C PF02984.19 EDN05148.1 - 0.0096 16.0 0.0 3 7.9 0.0 2.7 3 0 0 3 3 3 2 Cyclin, C-terminal domain DUF1610 PF07754.11 EDN05148.1 - 0.057 13.4 1.4 1.2 9.2 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) TFR_dimer PF04253.15 EDN05149.1 - 1.2e-36 125.4 0.1 2.2e-36 124.6 0.1 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDN05149.1 - 4e-19 69.1 0.0 8.2e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDN05149.1 - 2e-14 53.4 0.0 4.3e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 PA domain HMG_CoA_synt_C PF08540.10 EDN05150.1 - 1.8e-101 339.4 2.0 1.6e-99 333.1 2.0 2.2 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EDN05150.1 - 1.6e-97 324.4 0.8 2.5e-97 323.8 0.2 1.6 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal VP4_helical PF17478.2 EDN05150.1 - 0.1 12.0 0.4 7.4 5.9 0.1 2.2 2 0 0 2 2 2 0 Rotavirus VP4 helical domain GFO_IDH_MocA PF01408.22 EDN05152.1 - 6.6e-10 39.9 0.2 3.2e-09 37.6 0.2 2.0 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDN05152.1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain PGM_PMM_I PF02878.16 EDN05153.1 - 2.9e-33 114.5 0.1 4.2e-33 114.0 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EDN05153.1 - 2.5e-25 88.9 0.0 4.7e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EDN05153.1 - 6.7e-17 62.0 0.0 1.6e-16 60.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EDN05153.1 - 3.7e-08 33.4 0.0 7.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RNase_T PF00929.24 EDN05154.1 - 4e-25 89.3 0.0 4.5e-25 89.1 0.0 1.0 1 0 0 1 1 1 1 Exonuclease RVT_1 PF00078.27 EDN05156.1 - 3.8e-26 92.0 0.0 5.5e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CLPTM1 PF05602.12 EDN05159.1 - 0.039 13.0 0.2 0.043 12.8 0.2 1.0 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF5038 PF16441.5 EDN05159.1 - 0.083 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5038) DUF4265 PF14085.6 EDN05159.1 - 0.091 12.7 0.1 3.4 7.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) Helo_like_N PF17111.5 EDN05160.1 - 1.3e-26 93.2 10.1 4.5e-21 75.2 1.4 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins Takusan PF04822.13 EDN05160.1 - 0.088 12.7 3.1 0.15 11.9 0.4 2.6 1 1 1 2 2 2 0 Takusan RPAP2_Rtr1 PF04181.13 EDN05160.1 - 0.22 11.9 5.2 7.3 7.0 5.0 2.4 1 1 1 2 2 2 0 Rtr1/RPAP2 family ING PF12998.7 EDN05160.1 - 0.25 11.9 3.8 0.26 11.9 1.6 2.1 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Exonuc_VII_L PF02601.15 EDN05160.1 - 0.36 10.4 8.5 12 5.4 8.8 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit PIN_8 PF18476.1 EDN05160.1 - 0.68 9.7 6.5 2.1 8.2 6.5 1.8 1 1 0 1 1 1 0 PIN like domain Salp15 PF12115.8 EDN05160.1 - 4.2 7.8 6.2 1.1e+02 3.3 6.2 2.3 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation SCAN PF02023.17 EDN05161.1 - 0.043 13.6 1.6 0.08 12.8 1.6 1.4 1 0 0 1 1 1 0 SCAN domain Rep-A_N PF04057.12 EDN05161.1 - 0.18 11.8 0.1 0.33 11.0 0.1 1.3 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Swm2 PF17083.5 EDN05161.1 - 0.18 11.8 0.2 0.28 11.2 0.2 1.2 1 0 0 1 1 1 0 Nucleolar protein Swm2 CAP59_mtransfer PF11735.8 EDN05163.1 - 2.5e-85 286.0 0.0 3.4e-85 285.6 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Suc_Fer-like PF06999.12 EDN05164.1 - 1.2e-59 201.5 0.0 1.5e-59 201.2 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Fungal_trans PF04082.18 EDN05165.1 - 6.2e-17 61.5 1.5 1.5e-16 60.3 1.5 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN05165.1 - 6.6e-07 29.3 5.4 1.5e-06 28.2 5.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 EDN05166.1 - 4.7e-48 163.8 8.8 1.3e-45 155.8 8.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN05166.1 - 1.1e-36 126.1 6.2 1.5e-20 73.5 0.8 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDN05166.1 - 1.4e-06 28.3 1.7 3.1e-05 24.0 0.8 2.1 2 0 0 2 2 2 1 KR domain SMC_N PF02463.19 EDN05168.1 - 3.4e-77 258.8 0.0 9.1e-77 257.4 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDN05168.1 - 1.8e-24 86.3 0.1 8.8e-24 84.1 0.0 2.4 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDN05168.1 - 1.5e-11 44.7 5.8 1.5e-05 25.0 0.1 3.7 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDN05168.1 - 0.00083 19.1 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tektin PF03148.14 EDN05168.1 - 0.0011 17.8 9.0 0.0011 17.8 9.0 5.1 3 2 1 4 4 4 2 Tektin family SbcCD_C PF13558.6 EDN05168.1 - 0.04 14.1 0.0 0.68 10.2 0.0 3.0 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EDN05168.1 - 2 8.9 0.0 2 8.9 0.0 5.9 3 2 0 4 4 4 0 ABC transporter ELYS PF13934.6 EDN05169.1 - 1.5e-67 227.8 2.1 1.9e-67 227.5 2.1 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly zf_CCCH_4 PF18345.1 EDN05170.1 - 1.4e-05 24.9 5.4 2.5e-05 24.2 5.4 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDN05170.1 - 1.9e-05 24.4 2.9 4.1e-05 23.3 2.9 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EDN05170.1 - 6.9e-05 22.6 1.7 0.00012 21.9 1.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_S10 PF00338.22 EDN05171.1 - 4.4e-26 91.0 0.4 5.2e-26 90.7 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e CUE PF02845.16 EDN05172.1 - 9.6e-10 38.0 0.0 1.7e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain Nucleo_P87 PF07267.11 EDN05172.1 - 0.15 10.9 0.6 0.19 10.5 0.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FA_desaturase PF00487.24 EDN05173.1 - 1.2e-24 87.5 30.8 2.2e-24 86.7 30.8 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EDN05173.1 - 1.9e-08 34.3 0.0 4.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PGM_PMM_II PF02879.16 EDN05174.1 - 5.3e-26 91.2 0.0 1.2e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_I PF02878.16 EDN05174.1 - 1.5e-23 83.0 0.0 2.6e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EDN05174.1 - 1.5e-13 51.0 0.0 3e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EDN05174.1 - 3.8e-09 36.6 0.0 9.7e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pyr_redox_2 PF07992.14 EDN05175.1 - 2.1e-69 234.0 11.9 1.3e-68 231.4 9.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDN05175.1 - 8.6e-40 135.4 2.0 1e-39 135.2 0.4 2.1 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDN05175.1 - 3.3e-21 75.6 10.1 1.4e-19 70.4 1.1 3.0 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDN05175.1 - 4.6e-11 42.7 10.9 1.4e-10 41.1 0.3 2.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EDN05175.1 - 1.6e-10 40.7 10.0 1e-08 34.7 3.1 2.7 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDN05175.1 - 1.6e-09 37.8 6.0 1.9e-05 24.8 0.5 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EDN05175.1 - 6e-09 35.5 5.4 0.00068 19.0 0.8 3.7 3 1 1 4 4 4 2 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EDN05175.1 - 1.4e-08 34.4 8.6 9.3e-07 28.4 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDN05175.1 - 1.1e-07 31.3 11.0 1.3e-07 31.1 3.0 2.5 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EDN05175.1 - 1.4e-06 27.3 15.4 9.1e-05 21.3 2.0 3.9 4 0 0 4 4 4 3 HI0933-like protein K_oxygenase PF13434.6 EDN05175.1 - 1.6e-06 27.5 0.7 0.059 12.5 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EDN05175.1 - 9e-06 25.1 2.9 0.00014 21.2 0.1 2.5 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EDN05175.1 - 2.5e-05 24.0 15.0 0.0087 15.7 0.6 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDN05175.1 - 0.00026 20.2 1.3 0.031 13.4 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 EDN05175.1 - 0.0057 15.9 12.1 0.019 14.2 1.4 3.0 2 1 0 2 2 2 2 FAD binding domain MraZ PF02381.18 EDN05175.1 - 0.16 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 MraZ protein, putative antitoxin-like NAD_binding_7 PF13241.6 EDN05175.1 - 0.19 12.2 6.9 0.29 11.6 0.1 3.2 3 1 0 3 3 3 0 Putative NAD(P)-binding FMO-like PF00743.19 EDN05175.1 - 0.34 9.3 3.7 0.24 9.8 0.9 1.9 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like Trp_halogenase PF04820.14 EDN05175.1 - 0.36 9.6 7.2 0.37 9.6 0.7 2.3 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 EDN05175.1 - 9.5 6.1 11.2 0.17 11.7 0.9 2.7 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CHORD PF04968.12 EDN05177.1 - 3.4e-06 27.7 2.6 1e-05 26.1 2.6 1.8 1 0 0 1 1 1 1 CHORD BTK PF00779.19 EDN05177.1 - 0.046 13.5 0.6 0.11 12.4 0.6 1.7 1 0 0 1 1 1 0 BTK motif Sugar_tr PF00083.24 EDN05179.1 - 7.7e-31 107.4 32.2 2.3e-17 63.0 12.2 3.3 2 2 2 4 4 4 3 Sugar (and other) transporter MFS_1 PF07690.16 EDN05179.1 - 2.6e-14 52.9 38.1 6.1e-12 45.1 13.8 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily ATP-sulfurylase PF01747.17 EDN05180.1 - 0.088 12.3 0.2 0.088 12.3 0.2 1.5 2 0 0 2 2 2 0 ATP-sulfurylase UBA_e1_thiolCys PF10585.9 EDN05180.1 - 0.12 12.3 0.7 0.19 11.7 0.7 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site Myc_N PF01056.18 EDN05180.1 - 0.16 11.8 3.4 1.8 8.4 4.1 1.9 2 0 0 2 2 2 0 Myc amino-terminal region FmdA_AmdA PF03069.15 EDN05181.1 - 1.2e-172 574.0 0.0 1.4e-172 573.7 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family FAD_binding_4 PF01565.23 EDN05182.1 - 2.2e-22 79.3 3.0 4.4e-22 78.3 3.0 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EDN05182.1 - 8.9e-10 38.5 1.6 3e-09 36.8 0.8 2.2 2 0 0 2 2 2 1 Berberine and berberine like Pro_isomerase PF00160.21 EDN05183.1 - 4.2e-30 105.1 0.1 6.7e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EDN05183.1 - 8.6e-05 22.4 11.2 8.7e-05 22.3 3.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDN05183.1 - 0.00021 21.0 5.8 0.00025 20.8 1.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN05183.1 - 0.0012 18.9 3.5 0.0021 18.1 1.8 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDN05183.1 - 0.0018 18.6 4.2 0.0018 18.6 4.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDN05183.1 - 0.012 15.7 2.2 0.15 12.2 1.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDN05183.1 - 0.11 13.2 10.0 0.34 11.6 9.4 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN05183.1 - 0.17 12.8 6.1 0.79 10.7 4.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN05183.1 - 1.4 9.7 4.7 1.6 9.6 0.7 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat DSBA PF01323.20 EDN05183.1 - 2.8 7.7 6.0 1.4 8.6 2.7 1.9 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Tyr_Deacylase PF02580.16 EDN05184.1 - 8.9e-53 178.7 0.1 1e-52 178.5 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Not3 PF04065.15 EDN05185.1 - 5.8e-87 290.9 15.7 9e-87 290.3 15.7 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EDN05185.1 - 9.2e-43 145.5 12.2 2.4e-42 144.1 12.2 1.8 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 EDN05185.1 - 0.026 14.4 3.8 0.058 13.2 3.8 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) CLZ PF16526.5 EDN05185.1 - 0.14 12.5 3.0 0.22 11.9 0.7 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Syntaxin_2 PF14523.6 EDN05185.1 - 0.82 10.1 8.6 0.12 12.8 3.1 2.4 2 0 0 2 2 2 0 Syntaxin-like protein RPW8 PF05659.11 EDN05185.1 - 0.93 9.2 6.0 0.33 10.6 0.6 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Sec5 PF15469.6 EDN05185.1 - 1.4 8.7 7.7 0.42 10.4 1.0 2.3 2 0 0 2 2 2 0 Exocyst complex component Sec5 zf-C2H2_aberr PF17017.5 EDN05187.1 - 7.4e-05 23.0 0.4 0.00011 22.3 0.4 1.3 1 0 0 1 1 1 1 Aberrant zinc-finger zf-C2H2 PF00096.26 EDN05187.1 - 0.00032 21.0 6.7 0.12 12.8 0.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 EDN05187.1 - 0.004 17.8 0.8 0.23 12.1 0.1 2.4 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EDN05187.1 - 0.061 14.2 5.2 0.84 10.7 0.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger DNA_binding_1 PF01035.20 EDN05188.1 - 4.4e-25 87.6 0.0 6.4e-25 87.1 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Pkinase PF00069.25 EDN05189.1 - 3.2e-21 75.9 0.0 2.7e-16 59.7 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05189.1 - 0.01 15.1 0.0 0.024 13.9 0.0 1.7 1 1 0 1 1 1 0 Protein tyrosine kinase TMEM234 PF10639.9 EDN05190.1 - 8.2e-35 119.3 1.1 2.5e-34 117.8 1.1 1.7 1 1 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 EDN05190.1 - 0.0086 16.2 6.9 0.3 11.3 3.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF3299 PF11736.8 EDN05190.1 - 0.036 14.1 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) DUF1211 PF06736.11 EDN05190.1 - 0.049 14.1 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) Pkinase PF00069.25 EDN05191.1 - 1.8e-08 34.1 0.1 2e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN05191.1 - 9.7e-05 21.8 0.3 0.00015 21.2 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN05191.1 - 0.00011 21.1 0.1 0.00014 20.7 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDN05191.1 - 0.0035 17.3 1.1 0.0052 16.7 0.9 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Deltaretro_Tax PF05599.11 EDN05191.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 Deltaretrovirus Tax protein B PF02216.16 EDN05191.1 - 0.21 11.6 0.2 0.97 9.5 0.0 2.1 2 0 0 2 2 2 0 B domain Chitin_synth_1 PF01644.17 EDN05192.1 - 1.6e-75 252.6 0.0 2.4e-75 252.0 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDN05192.1 - 1.3e-29 101.9 0.0 2.7e-29 100.9 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDN05192.1 - 6.2e-21 74.6 4.2 5.4e-17 61.6 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EDN05192.1 - 0.00022 21.2 16.0 0.00022 21.2 16.0 3.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 LMWPc PF01451.21 EDN05193.1 - 3.4e-36 124.7 0.0 1.3e-30 106.7 0.0 2.1 2 0 0 2 2 2 2 Low molecular weight phosphotyrosine protein phosphatase SLIDE PF09111.10 EDN05193.1 - 0.14 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 SLIDE COQ7 PF03232.13 EDN05194.1 - 7.8e-68 227.6 0.1 1.2e-67 227.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EDN05194.1 - 0.00029 21.2 0.0 0.00063 20.2 0.0 1.6 1 1 0 1 1 1 1 Rubrerythrin HydF_dimer PF18128.1 EDN05194.1 - 0.055 13.5 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Hydrogen maturase F dimerization domain Crr6 PF08847.11 EDN05194.1 - 0.13 11.9 0.0 0.47 10.1 0.0 1.8 1 1 1 2 2 2 0 Chlororespiratory reduction 6 Coat_F PF07875.12 EDN05194.1 - 0.18 12.1 0.1 15 5.9 0.0 2.9 3 0 0 3 3 3 0 Coat F domain Plus-3 PF03126.18 EDN05195.1 - 6.2e-33 113.6 1.0 1e-31 109.6 0.0 2.6 3 0 0 3 3 3 1 Plus-3 domain MRC1 PF09444.10 EDN05196.1 - 1.7e-24 87.0 22.0 1.6e-21 77.3 6.7 8.6 5 3 3 8 8 8 2 MRC1-like domain DUF1082 PF06449.11 EDN05197.1 - 0.075 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial domain of unknown function (DUF1082) MIF4G PF02854.19 EDN05198.1 - 9.1e-21 74.5 0.7 2.5e-20 73.1 0.2 2.0 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.17 EDN05198.1 - 2.7e-18 66.0 0.0 1e-17 64.1 0.0 2.0 2 0 0 2 2 2 1 MA3 domain HHV-5_US34A PF17087.5 EDN05198.1 - 1.9 8.7 9.9 3 8.1 2.2 3.3 3 0 0 3 3 3 0 Herpesvirus US34A protein family SRP14 PF02290.15 EDN05199.1 - 2.2e-27 95.2 0.0 3e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle 14kD protein MSA-2c PF12238.8 EDN05199.1 - 0.35 10.8 2.1 0.41 10.6 2.1 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c EI24 PF07264.11 EDN05201.1 - 2.5e-19 70.2 7.0 4.1e-19 69.5 7.0 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF2062 PF09835.9 EDN05201.1 - 0.0076 16.1 4.6 0.52 10.2 0.3 2.8 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2062) F-box-like PF12937.7 EDN05202.1 - 0.00087 19.1 0.5 0.0018 18.1 0.5 1.5 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EDN05202.1 - 0.0063 16.8 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 PRANC domain F-box PF00646.33 EDN05202.1 - 0.0086 15.9 0.3 0.026 14.4 0.3 1.8 1 0 0 1 1 1 1 F-box domain SLT PF01464.20 EDN05204.1 - 0.0015 18.2 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain NAGidase PF07555.13 EDN05205.1 - 3.9e-99 331.7 0.2 9.5e-99 330.4 0.2 1.6 1 1 1 2 2 2 1 beta-N-acetylglucosaminidase Glyco_hydro_20b PF02838.15 EDN05205.1 - 3.2e-12 47.3 0.0 8.6e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_67N PF03648.14 EDN05205.1 - 0.0042 17.3 0.0 0.0096 16.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Abhydrolase_6 PF12697.7 EDN05207.1 - 1.1e-26 94.8 1.2 1.4e-26 94.4 1.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family MFS_MOT1 PF16983.5 EDN05210.1 - 2.1e-65 218.1 32.7 3.8e-34 117.4 9.1 3.2 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily BenE PF03594.13 EDN05210.1 - 0.0002 20.3 12.6 0.18 10.6 0.1 2.8 2 1 0 2 2 2 2 Benzoate membrane transport protein Sulfate_transp PF00916.20 EDN05210.1 - 0.001 17.9 4.6 0.001 17.9 4.6 2.5 1 1 1 2 2 2 1 Sulfate permease family FUSC-like PF12805.7 EDN05210.1 - 0.38 9.8 2.0 0.69 9.0 2.0 1.4 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS PhyH PF05721.13 EDN05211.1 - 7.4e-43 147.3 0.0 1.6e-42 146.2 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) UTP15_C PF09384.10 EDN05212.1 - 2.2e-54 183.2 0.2 1e-53 181.0 0.0 2.0 1 1 1 2 2 2 1 UTP15 C terminal WD40 PF00400.32 EDN05212.1 - 6.1e-21 74.4 2.5 1.5e-06 28.8 0.0 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05212.1 - 1.7e-06 28.2 0.2 0.22 11.8 0.0 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EDN05212.1 - 0.0067 16.0 0.9 3.4 7.2 0.2 2.6 2 0 0 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 EDN05212.1 - 10 6.8 9.8 53 4.5 0.0 4.8 6 0 0 6 6 6 0 PQQ-like domain C2 PF00168.30 EDN05213.1 - 4e-16 59.2 0.0 7e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain DDE_1 PF03184.19 EDN05215.1 - 6.7e-20 71.5 0.0 1.4e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05215.1 - 1.1e-12 47.8 0.1 3.6e-12 46.1 0.1 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN05215.1 - 0.0018 18.0 0.1 0.0042 16.8 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN05215.1 - 0.0074 16.0 0.1 0.026 14.3 0.1 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HNH_2 PF13391.6 EDN05216.1 - 1.2e-06 28.6 0.2 1.8e-06 27.9 0.2 1.3 1 0 0 1 1 1 1 HNH endonuclease AAA_12 PF13087.6 EDN05217.1 - 1.9e-23 83.1 0.0 2.4e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EDN05217.1 - 0.035 13.9 0.0 0.12 12.2 0.0 2.0 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2967 PF11179.8 EDN05217.1 - 9.5 4.2 5.9 12 3.8 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF2997 PF11211.8 EDN05218.1 - 0.18 11.6 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) AJAP1_PANP_C PF15298.6 EDN05219.1 - 1.2 9.3 7.5 0.058 13.6 1.0 2.0 2 0 0 2 2 2 0 AJAP1/PANP C-terminus RRM_1 PF00076.22 EDN05221.1 - 1.9e-50 168.6 0.0 7.1e-17 61.0 0.0 5.4 6 0 0 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN05221.1 - 2.7e-34 116.9 0.0 8.2e-29 99.3 0.0 4.1 3 1 1 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDN05221.1 - 1.9e-05 24.6 0.0 0.16 12.0 0.0 2.8 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif TPR_14 PF13428.6 EDN05221.1 - 0.00062 20.4 1.1 2.1 9.4 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat RRM_7 PF16367.5 EDN05221.1 - 0.0048 17.0 0.0 0.096 12.8 0.0 3.0 3 0 0 3 3 3 1 RNA recognition motif Lsm_interact PF05391.11 EDN05221.1 - 0.016 14.7 0.5 0.035 13.6 0.5 1.6 1 0 0 1 1 1 0 Lsm interaction motif RL PF17797.1 EDN05221.1 - 0.069 13.1 0.0 0.3 11.1 0.0 2.0 2 0 0 2 2 2 0 RL domain DUF2335 PF10097.9 EDN05221.1 - 0.12 12.4 0.9 0.42 10.6 0.9 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2335) DUF1610 PF07754.11 EDN05222.1 - 0.13 12.3 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) L_HMGIC_fpl PF10242.9 EDN05223.1 - 0.001 19.3 7.8 0.0026 18.0 7.7 1.8 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein His_Phos_1 PF00300.22 EDN05224.1 - 4.7e-11 42.8 0.0 1.3e-10 41.3 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) HNH_2 PF13391.6 EDN05225.1 - 3.4e-09 36.7 0.0 6.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease MARVEL PF01284.23 EDN05229.1 - 2.5e-20 73.0 12.5 2.9e-20 72.8 12.5 1.0 1 0 0 1 1 1 1 Membrane-associating domain Pkinase PF00069.25 EDN05230.1 - 6.2e-45 153.6 0.0 3e-44 151.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05230.1 - 2.1e-19 69.8 0.0 3.7e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EDN05230.1 - 1.8e-16 60.6 0.7 2.3e-07 31.3 0.2 3.5 2 1 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EDN05230.1 - 1.1e-12 47.9 0.0 2.6e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EDN05230.1 - 1.1e-05 24.9 0.2 3.1e-05 23.4 0.0 1.8 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EDN05230.1 - 0.019 14.0 0.1 0.03 13.3 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDN05230.1 - 0.03 14.2 0.0 0.067 13.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EDN05230.1 - 0.063 12.2 0.2 0.095 11.6 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PRELI PF04707.14 EDN05231.1 - 3.6e-25 88.6 0.0 1.1e-21 77.2 0.0 2.2 2 0 0 2 2 2 2 PRELI-like family UQ_con PF00179.26 EDN05232.1 - 9.1e-28 96.7 0.0 1.2e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDN05232.1 - 0.15 12.4 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain Chitin_synth_1 PF01644.17 EDN05233.1 - 8.7e-70 233.9 0.0 1.3e-69 233.4 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDN05233.1 - 2.3e-28 97.9 0.0 4.6e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDN05233.1 - 1.5e-23 83.2 0.1 1e-18 67.3 0.0 2.1 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EDN05233.1 - 3.3e-08 33.7 0.5 3.3e-08 33.7 0.5 2.9 4 1 0 4 4 4 1 Glycosyl transferase family group 2 Aminotran_4 PF01063.19 EDN05234.1 - 5.5e-27 95.1 0.0 1.3e-26 93.9 0.0 1.6 1 1 0 1 1 1 1 Amino-transferase class IV TAF8_C PF10406.9 EDN05236.1 - 1.2e-22 80.2 0.3 3.2e-22 78.8 0.3 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EDN05236.1 - 2.2e-07 30.8 0.0 5e-07 29.6 0.0 1.6 2 0 0 2 2 2 1 Bromodomain associated Mitochondr_Som1 PF11093.8 EDN05237.1 - 4.2e-15 55.5 0.1 4.7e-15 55.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Rad51 PF08423.11 EDN05238.1 - 0.079 12.2 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Rad51 PALP PF00291.25 EDN05239.1 - 1.1e-62 212.1 6.5 2.5e-62 210.9 6.5 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4597 PF15366.6 EDN05239.1 - 0.08 12.7 0.5 0.52 10.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) IlvN PF07991.12 EDN05240.1 - 1e-44 152.0 0.0 1.7e-44 151.3 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EDN05240.1 - 2.5e-40 138.1 0.0 4e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 EDN05240.1 - 0.063 13.4 0.0 0.16 12.1 0.0 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase DUF5134 PF17197.4 EDN05240.1 - 0.29 11.0 3.6 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) 2OG-FeII_Oxy_2 PF13532.6 EDN05241.1 - 2.1e-24 86.8 0.1 5.7e-24 85.4 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EDN05241.1 - 1.1e-21 77.7 0.0 5.4e-14 52.8 0.0 2.4 2 0 0 2 2 2 2 Isochorismatase family GST_C_2 PF13410.6 EDN05241.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SGT1 PF07093.11 EDN05241.1 - 3.6 5.9 5.4 5.5 5.3 5.4 1.2 1 0 0 1 1 1 0 SGT1 protein ECH_1 PF00378.20 EDN05242.1 - 3.2e-34 118.4 0.0 1.1e-33 116.6 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN05242.1 - 2.1e-23 83.4 0.0 4.2e-22 79.1 0.0 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase DUF2188 PF09954.9 EDN05242.1 - 0.081 13.1 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) Methyltrn_RNA_4 PF09936.9 EDN05242.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase HeLo PF14479.6 EDN05243.1 - 0.057 13.2 0.6 1.2 8.9 0.6 2.5 1 1 0 1 1 1 0 Prion-inhibition and propagation zf-Di19 PF05605.12 EDN05244.1 - 0.17 12.2 1.8 23 5.4 0.2 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-nanos PF05741.13 EDN05244.1 - 0.88 9.9 3.7 15 5.9 0.2 2.9 3 0 0 3 3 3 0 Nanos RNA binding domain zf-C2H2 PF00096.26 EDN05244.1 - 1.7 9.3 17.0 0.15 12.6 0.9 4.0 4 0 0 4 4 4 0 Zinc finger, C2H2 type RNA_pol_Rpb1_1 PF04997.12 EDN05245.1 - 1.5e-83 280.8 0.0 2.5e-83 280.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EDN05245.1 - 4.5e-80 268.9 1.4 7.2e-80 268.2 1.4 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDN05245.1 - 7.4e-72 241.0 0.1 1.8e-71 239.7 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDN05245.1 - 7.6e-36 123.4 0.0 2.4e-35 121.8 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDN05245.1 - 1.7e-27 95.5 0.0 4.4e-27 94.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 GTP_EFTU PF00009.27 EDN05246.1 - 1.3e-50 171.6 0.0 2.1e-50 171.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EDN05246.1 - 6.8e-41 138.8 4.8 1.1e-40 138.0 4.8 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EDN05246.1 - 1.7e-19 69.7 0.0 3e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EDN05246.1 - 4.8e-05 23.4 0.0 0.00012 22.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EDN05246.1 - 0.00028 21.2 0.0 0.00073 19.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 EDN05246.1 - 0.00045 19.8 0.0 0.00099 18.7 0.0 1.6 1 0 0 1 1 1 1 Ras family EFG_II PF14492.6 EDN05246.1 - 0.0052 16.9 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 EDN05246.1 - 0.013 15.3 0.0 0.055 13.3 0.0 2.0 2 0 0 2 2 2 0 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EDN05246.1 - 0.036 13.5 0.0 0.081 12.3 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 EDN05246.1 - 0.053 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Snurportin1 PF11538.8 EDN05246.1 - 0.084 13.1 1.8 0.28 11.4 1.8 1.8 1 0 0 1 1 1 0 Snurportin1 HORMA PF02301.18 EDN05247.1 - 2.3e-34 118.9 0.0 2.6e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 EDN05247.1 - 0.0066 16.4 0.2 0.041 13.9 0.2 2.3 1 1 0 1 1 1 1 Autophagy-related protein 101 DUF2660 PF10859.8 EDN05247.1 - 0.093 13.2 0.1 0.22 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) Csm1_B PF18211.1 EDN05247.1 - 0.16 11.9 0.7 0.28 11.0 0.1 1.8 2 1 0 2 2 2 0 Csm1 subunit domain B Synthase_beta PF11421.8 EDN05247.1 - 2.2 9.0 4.2 4.7 8.0 4.2 1.5 1 0 0 1 1 1 0 ATP synthase F1 beta subunit Sec1 PF00995.23 EDN05249.1 - 1.7e-108 364.4 0.0 1.3e-77 262.4 0.0 2.0 1 1 1 2 2 2 2 Sec1 family SAM_Exu PF18609.1 EDN05251.1 - 0.011 15.8 0.0 0.034 14.2 0.0 1.8 1 1 1 2 2 2 0 Exuperantia SAM-like domain DUF755 PF05501.11 EDN05251.1 - 0.15 12.4 4.0 0.22 11.8 2.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF4692 PF15763.5 EDN05251.1 - 1.5 9.3 7.7 0.49 10.8 5.1 1.5 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) zf_CCCH_4 PF18345.1 EDN05252.1 - 2.2e-05 24.3 3.0 3.8e-05 23.6 3.0 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDN05252.1 - 0.00059 19.6 1.9 0.00097 18.9 1.9 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EDN05252.1 - 0.0016 18.9 1.9 0.0027 18.1 1.9 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger GRP PF07172.11 EDN05252.1 - 0.016 15.9 4.8 0.031 14.9 4.8 1.5 1 0 0 1 1 1 0 Glycine rich protein family zf-CCCH_3 PF15663.5 EDN05252.1 - 0.027 14.7 0.2 0.059 13.6 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger containing family FHA PF00498.26 EDN05253.1 - 1.5e-11 44.5 0.0 4.1e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 FHA domain TPR_1 PF00515.28 EDN05254.1 - 1.3e-35 119.7 33.7 2.5e-06 27.1 0.0 11.4 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 EDN05254.1 - 3.5e-34 114.2 32.3 0.00013 21.8 0.4 11.6 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_16 PF13432.6 EDN05254.1 - 1.5e-22 79.9 17.0 1.4e-07 32.0 0.6 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN05254.1 - 5.2e-20 70.9 26.8 4.1e-07 29.6 0.0 8.4 5 2 3 8 8 8 5 TPR repeat TPR_8 PF13181.6 EDN05254.1 - 1e-19 69.0 27.2 0.0048 17.0 0.0 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 EDN05254.1 - 3e-17 61.7 15.5 0.0056 17.0 0.0 9.2 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EDN05254.1 - 3.1e-14 53.0 32.6 0.011 16.0 1.3 8.3 3 2 5 8 8 8 7 Tetratricopeptide repeat TPR_9 PF13371.6 EDN05254.1 - 6.7e-13 48.6 14.9 2.3e-07 30.9 1.8 5.2 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDN05254.1 - 1.2e-12 48.2 25.2 1.7e-05 25.3 1.1 7.3 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 EDN05254.1 - 2.3e-09 36.6 21.2 0.034 14.2 0.3 9.4 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDN05254.1 - 4.9e-09 36.3 27.4 0.015 16.0 0.6 9.4 4 2 6 10 10 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN05254.1 - 4.4e-06 26.8 19.4 0.31 11.3 0.2 5.9 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EDN05254.1 - 5.5e-05 22.7 8.8 9.4e-05 21.9 4.0 2.8 1 1 0 2 2 2 1 MalT-like TPR region SHNi-TPR PF10516.9 EDN05254.1 - 7.1e-05 22.2 10.6 3.8 7.0 0.1 6.4 6 0 0 6 6 6 2 SHNi-TPR TPR_10 PF13374.6 EDN05254.1 - 0.00065 19.5 27.0 0.79 9.7 0.4 8.8 9 0 0 9 9 9 1 Tetratricopeptide repeat MAS20 PF02064.15 EDN05254.1 - 0.0043 17.1 7.1 0.098 12.7 0.7 4.0 3 1 1 4 4 4 1 MAS20 protein import receptor TPR_6 PF13174.6 EDN05254.1 - 0.0079 16.8 18.9 7.5 7.4 0.3 8.8 9 0 0 9 9 9 0 Tetratricopeptide repeat DUF3856 PF12968.7 EDN05254.1 - 0.015 15.4 6.1 2.4 8.2 0.0 4.3 4 2 0 4 4 4 0 Domain of Unknown Function (DUF3856) TAF1_subA PF14929.6 EDN05254.1 - 0.018 14.5 1.3 0.042 13.3 0.2 2.0 2 1 0 2 2 2 0 TAF RNA Polymerase I subunit A Sel1 PF08238.12 EDN05254.1 - 0.03 15.0 0.3 21 6.0 0.0 3.5 2 0 0 2 2 2 0 Sel1 repeat DUF3306 PF11748.8 EDN05254.1 - 0.058 14.3 4.6 0.17 12.7 4.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) preATP-grasp_3 PF18301.1 EDN05254.1 - 0.081 13.2 0.2 0.28 11.5 0.2 1.9 1 0 0 1 1 1 0 pre ATP-grasp 3 domain PPR PF01535.20 EDN05254.1 - 0.086 13.1 0.1 1.3e+02 3.2 0.0 4.3 3 0 0 3 3 3 0 PPR repeat NARP1 PF12569.8 EDN05254.1 - 0.64 8.9 22.5 0.19 10.6 0.1 4.2 3 1 2 5 5 5 0 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 EDN05254.1 - 0.65 10.8 13.5 30 5.6 0.2 6.5 6 0 0 6 6 5 0 Tetratricopeptide repeat MIT PF04212.18 EDN05254.1 - 4.1 7.5 16.8 52 4.0 0.0 6.5 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain Zip PF02535.22 EDN05255.1 - 9e-43 146.8 9.3 1.3e-42 146.2 9.3 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter HupE_UreJ PF04955.12 EDN05255.1 - 0.00049 19.6 7.5 0.00049 19.6 7.5 2.5 2 1 0 2 2 2 1 HupE / UreJ protein Thyroglobulin_1 PF00086.18 EDN05255.1 - 0.21 11.3 4.2 15 5.4 0.5 3.4 1 1 2 3 3 3 0 Thyroglobulin type-1 repeat DUF2052 PF09747.9 EDN05256.1 - 0.0019 18.4 1.6 0.0025 18.0 1.6 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) DNA_pol_phi PF04931.13 EDN05256.1 - 0.028 12.5 4.7 0.034 12.3 4.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 EDN05256.1 - 0.066 12.4 0.7 0.095 11.9 0.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cnd2 PF05786.14 EDN05256.1 - 0.35 9.5 6.1 0.47 9.0 6.1 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 RPN2_C PF18004.1 EDN05256.1 - 0.53 10.2 6.1 0.83 9.6 6.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain E7 PF00527.18 EDN05256.1 - 0.57 10.4 3.5 1.2 9.3 3.5 1.5 1 0 0 1 1 1 0 E7 protein, Early protein Nop14 PF04147.12 EDN05256.1 - 2 6.5 12.5 1.1 7.4 8.7 1.9 2 0 0 2 2 2 0 Nop14-like family CDC45 PF02724.14 EDN05256.1 - 2.5 6.3 6.6 3.3 5.9 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 EDN05256.1 - 2.7 7.3 8.3 4.5 6.6 8.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Ycf1 PF05758.12 EDN05256.1 - 3.1 5.5 3.3 4.2 5.1 3.3 1.1 1 0 0 1 1 1 0 Ycf1 Paf1 PF03985.13 EDN05256.1 - 3.9 6.4 13.0 5.9 5.8 13.0 1.1 1 0 0 1 1 1 0 Paf1 TFIIF_alpha PF05793.12 EDN05256.1 - 4.2 5.9 13.6 5.8 5.4 13.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2457 PF10446.9 EDN05256.1 - 5.7 6.0 10.1 8.7 5.4 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4637 PF15470.6 EDN05256.1 - 9.8 5.9 12.2 18 5.0 12.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) FAD_binding_3 PF01494.19 EDN05257.1 - 7.6e-11 41.8 0.8 5e-08 32.6 0.0 2.9 3 0 0 3 3 3 2 FAD binding domain SE PF08491.10 EDN05257.1 - 0.026 13.6 0.0 0.2 10.7 0.0 2.3 2 1 1 3 3 3 0 Squalene epoxidase NAD_binding_8 PF13450.6 EDN05257.1 - 0.033 14.4 0.1 0.1 12.9 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Opy2 PF09463.10 EDN05258.1 - 1.1e-09 38.4 21.0 1.8e-09 37.8 21.0 1.3 1 0 0 1 1 1 1 Opy2 protein LapA_dom PF06305.11 EDN05258.1 - 0.062 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain LPG_synthase_TM PF03706.13 EDN05258.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Syndecan PF01034.20 EDN05258.1 - 0.15 12.0 0.1 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain Glyoxalase_6 PF18029.1 EDN05259.1 - 8.4e-07 29.8 0.0 1.2e-06 29.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 EDN05259.1 - 4.2e-05 23.7 0.0 9.9e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Tfb5 PF06331.12 EDN05260.1 - 7.3e-24 83.5 0.3 8.1e-24 83.4 0.3 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Toxin_trans PF07952.12 EDN05260.1 - 0.068 12.2 0.0 0.068 12.2 0.0 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain PHO4 PF01384.20 EDN05261.1 - 2.1e-111 372.2 9.3 2.4e-111 372.0 9.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family Tim17 PF02466.19 EDN05261.1 - 0.0034 17.8 0.2 0.047 14.1 0.0 2.9 2 1 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family PhyH PF05721.13 EDN05262.1 - 6.6e-15 55.9 0.2 3.6e-11 43.7 0.1 2.1 1 1 1 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) RVT_1 PF00078.27 EDN05263.1 - 1.8e-40 138.8 0.0 2.8e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN05263.1 - 7.9e-15 54.7 0.0 2.4e-14 53.2 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN05263.1 - 1.8e-06 27.7 0.3 8e-06 25.5 0.3 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Helicase_C PF00271.31 EDN05266.1 - 8.1e-15 55.1 0.1 2.2e-14 53.7 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN05266.1 - 2e-13 50.5 0.0 7.8e-13 48.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN05266.1 - 3.8e-07 30.3 0.0 2.9e-06 27.4 0.0 2.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit CCD48 PF15799.5 EDN05267.1 - 0.14 10.4 0.3 0.18 10.1 0.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Bul1_C PF04426.12 EDN05267.1 - 0.26 10.7 0.0 0.42 10.0 0.0 1.2 1 0 0 1 1 1 0 Bul1 C terminus DDE_1 PF03184.19 EDN05269.1 - 6.4e-23 81.3 0.0 1.1e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN05269.1 - 1.9e-05 24.4 0.0 0.00012 21.8 0.0 2.1 1 1 1 2 2 2 1 DDE superfamily endonuclease RNase_H PF00075.24 EDN05270.1 - 7.6e-08 32.6 0.0 1.3e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_2 PF07727.14 EDN05271.1 - 3.5e-36 125.1 0.0 2.1e-35 122.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_3 PF14244.6 EDN05272.1 - 0.012 15.4 0.1 0.023 14.5 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN05272.1 - 0.037 13.7 0.1 0.061 13.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) DUF4655 PF15548.6 EDN05272.1 - 0.58 9.1 5.1 0.73 8.7 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4655) BCS1_N PF08740.11 EDN05274.1 - 7.6e-36 123.8 0.0 1.3e-35 123.1 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN05274.1 - 1.1e-19 71.2 0.0 4.5e-19 69.2 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN05274.1 - 1.1e-05 25.9 0.1 2.8e-05 24.6 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN05274.1 - 0.045 12.6 0.0 0.078 11.8 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EDN05274.1 - 0.045 13.7 0.0 0.15 12.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDN05274.1 - 0.061 13.0 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDN05274.1 - 0.063 12.9 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EDN05274.1 - 0.076 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EDN05274.1 - 0.077 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EDN05274.1 - 0.12 12.9 0.0 1.8 9.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain Tegument_dsDNA PF12818.7 EDN05275.1 - 0.021 14.0 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein LRR_8 PF13855.6 EDN05277.1 - 0.12 12.1 0.5 0.22 11.3 0.5 1.4 1 0 0 1 1 1 0 Leucine rich repeat INTAP PF16617.5 EDN05277.1 - 1.1 9.6 4.4 0.29 11.5 1.1 1.7 2 0 0 2 2 2 0 Intersectin and clathrin adaptor AP2 binding region RNase_H PF00075.24 EDN05278.1 - 2.2e-06 27.9 0.0 4.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 RNase H DUF3435 PF11917.8 EDN05279.1 - 1.1e-163 545.0 0.6 1.4e-163 544.7 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN05279.1 - 1.3e-05 25.0 0.1 0.0013 18.6 0.0 2.6 2 0 0 2 2 2 2 Phage integrase family Peptidase_M24 PF00557.24 EDN05281.1 - 7e-47 159.8 0.1 9.4e-47 159.4 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDN05281.1 - 2.1e-19 69.5 0.0 3.9e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Nexin_C PF08628.12 EDN05282.1 - 3e-10 40.7 0.0 5.3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EDN05282.1 - 1.7e-07 31.2 0.1 3.5e-06 27.0 0.1 2.3 2 0 0 2 2 2 1 PX domain Acyl_transf_1 PF00698.21 EDN05283.1 - 6.4e-15 55.5 0.0 1.8e-12 47.4 0.0 2.1 2 0 0 2 2 2 2 Acyl transferase domain GDPD PF03009.17 EDN05284.1 - 0.0004 20.2 0.0 0.00058 19.7 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SKG6 PF08693.10 EDN05284.1 - 0.85 9.1 2.9 1.7 8.1 2.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ank_2 PF12796.7 EDN05285.1 - 5.5e-37 126.2 11.2 5.8e-10 39.6 0.0 3.8 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN05285.1 - 3.6e-28 97.6 2.6 2.7e-11 43.7 0.0 5.9 1 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN05285.1 - 6.6e-16 56.8 12.7 0.03 14.8 0.0 8.4 9 0 0 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EDN05285.1 - 1.5e-14 53.8 9.6 0.00041 20.6 0.1 6.6 1 1 6 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EDN05285.1 - 5.7e-11 42.3 12.4 0.01 16.3 0.0 8.2 9 0 0 9 9 9 3 Ankyrin repeat SKG6 PF08693.10 EDN05287.1 - 1e-07 31.2 3.4 1.8e-07 30.4 3.4 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain VSP PF03302.13 EDN05287.1 - 0.004 16.1 0.2 0.0056 15.6 0.2 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein DUF4448 PF14610.6 EDN05287.1 - 0.0043 16.8 0.0 0.0058 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Phage_holin_2_4 PF16082.5 EDN05287.1 - 0.011 15.5 0.1 0.019 14.7 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like DUF4381 PF14316.6 EDN05287.1 - 0.035 14.4 0.2 0.061 13.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) CcmD PF04995.14 EDN05287.1 - 0.041 14.0 1.3 0.059 13.5 1.3 1.2 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF2207 PF09972.9 EDN05287.1 - 0.13 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Stevor PF17410.2 EDN05287.1 - 0.25 10.9 0.1 0.33 10.5 0.1 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame SIT PF15330.6 EDN05287.1 - 0.27 11.7 0.0 0.49 10.9 0.0 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Ndc1_Nup PF09531.10 EDN05287.1 - 4.5 5.8 10.5 7.4 5.1 10.5 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Herpes_UL74 PF07982.12 EDN05288.1 - 0.013 14.5 2.9 0.016 14.2 2.9 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Sec62 PF03839.16 EDN05288.1 - 0.015 14.8 2.1 0.016 14.7 2.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 XRCC4 PF06632.12 EDN05288.1 - 0.043 12.7 3.2 0.045 12.6 3.2 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Peptidase_S49_N PF08496.10 EDN05288.1 - 0.2 11.7 3.8 0.26 11.3 3.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Coilin_N PF15862.5 EDN05288.1 - 0.53 10.1 7.9 0.77 9.6 7.9 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF3464 PF11947.8 EDN05288.1 - 1.7 8.4 6.0 2.4 7.9 6.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF1115 PF06544.12 EDN05288.1 - 9.8 6.3 12.4 14 5.7 12.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1115) Sugar_tr PF00083.24 EDN05289.1 - 1.2e-91 307.8 2.0 3.5e-89 299.7 2.0 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN05289.1 - 2.7e-20 72.6 37.2 3.8e-11 42.5 11.6 3.3 1 1 2 3 3 3 2 Major Facilitator Superfamily LacY_symp PF01306.19 EDN05289.1 - 9.7e-05 21.3 3.4 0.003 16.4 0.1 2.3 2 0 0 2 2 2 2 LacY proton/sugar symporter DUF829 PF05705.14 EDN05289.1 - 0.037 13.9 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) ABC_tran PF00005.27 EDN05290.1 - 9.1e-49 165.5 0.2 3.5e-23 82.6 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDN05290.1 - 3.2e-20 71.9 5.8 3.2e-20 71.9 5.8 3.7 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.6 EDN05290.1 - 2e-15 57.4 8.3 0.0018 18.1 0.0 4.6 3 2 0 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDN05290.1 - 1.2e-11 44.5 0.4 0.0059 16.1 0.0 4.6 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EDN05290.1 - 2e-06 27.7 8.7 0.2 11.3 0.0 5.3 5 1 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 EDN05290.1 - 5.5e-06 26.7 0.0 0.024 14.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EDN05290.1 - 7.7e-06 25.9 0.0 0.11 12.4 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDN05290.1 - 1.2e-05 25.0 0.6 0.17 11.6 0.1 3.1 2 1 1 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDN05290.1 - 1.3e-05 25.2 0.4 0.1 12.7 0.1 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EDN05290.1 - 2e-05 25.0 0.3 0.13 12.6 0.1 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_18 PF13238.6 EDN05290.1 - 2.2e-05 25.0 0.4 0.62 10.6 0.0 3.5 4 0 0 4 4 3 2 AAA domain AAA_23 PF13476.6 EDN05290.1 - 3.7e-05 24.3 15.2 0.03 14.8 0.0 4.9 5 0 0 5 5 5 2 AAA domain AAA_30 PF13604.6 EDN05290.1 - 9.8e-05 22.1 0.0 0.011 15.4 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 EDN05290.1 - 0.00018 21.3 0.7 0.79 9.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.6 EDN05290.1 - 0.00021 21.5 0.0 0.59 10.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EDN05290.1 - 0.00041 20.6 3.4 0.067 13.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA PF00004.29 EDN05290.1 - 0.0011 19.3 0.0 0.9 10.0 0.1 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDN05290.1 - 0.0016 18.4 0.1 0.88 9.5 0.0 2.6 2 0 0 2 2 2 1 NACHT domain MeaB PF03308.16 EDN05290.1 - 0.0032 16.5 0.1 2.7 6.9 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EDN05290.1 - 0.0055 17.1 0.0 3 8.3 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 EDN05290.1 - 0.0058 16.7 0.0 4.3 7.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 EDN05290.1 - 0.0091 15.6 1.4 4.7 6.8 0.0 3.3 3 1 1 4 4 3 0 AAA domain cobW PF02492.19 EDN05290.1 - 0.014 15.0 0.3 1 8.9 0.3 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 EDN05290.1 - 0.018 14.3 0.7 3.3 6.9 0.1 2.9 3 0 0 3 3 3 0 Zeta toxin NTPase_1 PF03266.15 EDN05290.1 - 0.019 14.9 0.0 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 NTPase MobB PF03205.14 EDN05290.1 - 0.02 14.8 0.0 0.44 10.5 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF677 PF05055.12 EDN05290.1 - 0.023 13.6 0.3 0.052 12.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF677) TsaE PF02367.17 EDN05290.1 - 0.028 14.4 0.0 7.3 6.6 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Decorin_bind PF02352.15 EDN05290.1 - 0.03 14.6 0.6 0.098 12.9 0.3 1.9 2 0 0 2 2 2 0 Decorin binding protein ATP-synt_ab PF00006.25 EDN05290.1 - 0.037 13.7 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain SRP54 PF00448.22 EDN05290.1 - 0.039 13.6 0.6 4 7.0 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Roc PF08477.13 EDN05290.1 - 0.041 14.1 0.1 9.8 6.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EDN05290.1 - 0.053 13.0 0.0 6.5 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region acVLRF1 PF18859.1 EDN05290.1 - 0.087 13.1 0.0 0.48 10.7 0.0 2.2 2 0 0 2 2 2 0 Actinobacteria/chloroflexi VLRF1 release factor AAA_5 PF07728.14 EDN05290.1 - 0.089 12.8 0.3 9.2 6.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EDN05290.1 - 0.092 11.9 0.4 13 4.8 0.0 2.6 3 0 0 3 3 2 0 NB-ARC domain Rad17 PF03215.15 EDN05290.1 - 0.12 12.3 0.1 4.1 7.3 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain PRK PF00485.18 EDN05290.1 - 0.12 12.1 0.7 7.4 6.3 0.1 2.9 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family Dynamin_N PF00350.23 EDN05290.1 - 0.21 11.6 11.5 1.6 8.8 0.0 3.9 3 1 0 4 4 3 0 Dynamin family DUF87 PF01935.17 EDN05290.1 - 0.35 10.9 8.2 2.2 8.3 0.0 4.1 5 0 0 5 5 4 0 Helicase HerA, central domain AAA_17 PF13207.6 EDN05290.1 - 3.4 8.1 6.5 22 5.5 0.2 3.8 4 0 0 4 4 3 0 AAA domain WD40 PF00400.32 EDN05295.1 - 5.3e-18 65.1 8.5 5.4e-05 23.9 0.5 4.7 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05295.1 - 2.8e-05 24.3 1.2 0.69 10.3 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ATP_synth_reg PF14960.6 EDN05295.1 - 0.011 15.2 0.3 0.021 14.3 0.3 1.4 1 0 0 1 1 1 0 ATP synthase regulation TFIIIC_delta PF12657.7 EDN05295.1 - 0.023 14.6 1.4 0.079 12.9 1.7 1.7 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 EDN05295.1 - 0.029 13.4 0.1 0.31 10.0 0.0 2.2 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SNF5 PF04855.12 EDN05298.1 - 5e-59 200.0 0.0 6e-59 199.7 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EDN05298.1 - 3.5e-05 23.3 2.3 3.5e-05 23.3 2.3 1.9 2 0 0 2 2 2 1 GATA zinc finger Rubredoxin_2 PF18073.1 EDN05298.1 - 0.19 11.5 4.9 0.34 10.7 1.4 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain Peptidase_M49 PF03571.15 EDN05299.1 - 9.3e-240 796.7 0.0 1.3e-239 796.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 Pkinase PF00069.25 EDN05300.1 - 1.1e-14 54.5 0.0 4.3e-14 52.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05300.1 - 7.4e-08 32.0 0.0 7.9e-07 28.6 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Aminotran_4 PF01063.19 EDN05302.1 - 3.3e-31 108.9 0.0 3.9e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV CK_II_beta PF01214.18 EDN05303.1 - 1e-20 74.3 0.0 1.4e-20 73.9 0.0 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit GCIP PF13324.6 EDN05303.1 - 0.07 12.7 1.8 0.11 12.0 1.8 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF2457 PF10446.9 EDN05303.1 - 0.23 10.5 8.5 4.2 6.4 4.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) PTPRCAP PF15713.5 EDN05303.1 - 0.34 11.2 5.0 1.3 9.3 2.0 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated PRP38_assoc PF12871.7 EDN05303.1 - 0.49 11.0 11.4 0.79 10.4 3.7 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term RRN3 PF05327.11 EDN05303.1 - 0.51 8.8 5.2 0.072 11.6 1.1 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Spt5_N PF11942.8 EDN05303.1 - 9.6 7.3 15.9 1.5 9.8 6.3 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Zn_clus PF00172.18 EDN05304.1 - 0.00073 19.6 10.7 0.0013 18.8 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF948 PF06103.11 EDN05304.1 - 0.21 11.9 0.3 2.3 8.5 0.0 2.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Cupin_8 PF13621.6 EDN05305.1 - 4.8e-11 42.9 0.0 5.7e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EDN05305.1 - 0.044 13.2 0.0 0.066 12.7 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein JmjC PF02373.22 EDN05305.1 - 0.048 14.1 0.0 0.071 13.5 0.0 1.2 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 EDN05305.1 - 0.088 12.5 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Cupin domain AA_permease PF00324.21 EDN05306.1 - 7.9e-97 324.8 24.9 9.6e-97 324.5 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDN05306.1 - 4.8e-19 68.5 25.4 6.3e-19 68.1 25.4 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.11 EDN05306.1 - 0.0071 16.7 1.2 0.0071 16.7 1.2 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF1772) Cyt-b5 PF00173.28 EDN05307.1 - 1.5e-08 34.7 0.0 1.6e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_1 PF00076.22 EDN05308.1 - 1.2e-60 201.2 0.0 2.3e-19 69.0 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EDN05308.1 - 2.9e-07 30.9 0.0 1.3 9.2 0.0 6.3 5 2 2 7 7 7 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EDN05308.1 - 0.00015 21.8 0.0 5.6 7.2 0.0 4.1 4 0 0 4 4 4 1 RNA recognition motif RRM_occluded PF16842.5 EDN05308.1 - 0.0014 18.5 0.0 0.065 13.1 0.0 2.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 EDN05308.1 - 0.0018 18.1 0.0 1.7 8.4 0.0 3.1 2 1 0 2 2 2 2 Rrp7 RRM-like N-terminal domain RRM_9 PF18444.1 EDN05308.1 - 0.0052 16.6 0.0 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif DbpA PF03880.15 EDN05308.1 - 0.0063 16.5 0.2 2.5 8.1 0.0 3.0 3 0 0 3 3 3 1 DbpA RNA binding domain RRM_5 PF13893.6 EDN05308.1 - 0.01 15.4 0.0 2 8.1 0.0 2.5 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EDN05308.1 - 0.039 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 BRCA1-associated protein 2 Nup35_RRM_2 PF14605.6 EDN05308.1 - 0.084 12.9 0.0 44 4.2 0.0 3.5 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 EDN05308.1 - 0.15 11.7 0.0 21 4.8 0.0 3.3 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Nitr_red_bet_C PF14711.6 EDN05309.1 - 0.11 12.2 3.6 11 5.7 2.1 2.6 2 0 0 2 2 2 0 Respiratory nitrate reductase beta C-terminal ABC_membrane PF00664.23 EDN05310.1 - 2.4e-48 165.1 15.2 4e-48 164.4 15.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDN05310.1 - 2.5e-45 154.4 0.0 1.7e-31 109.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDN05310.1 - 2.9e-12 46.5 3.8 8.1e-06 25.4 0.0 3.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EDN05310.1 - 9.2e-09 34.6 0.6 0.00077 18.4 0.1 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_21 PF13304.6 EDN05310.1 - 2.3e-05 24.3 0.0 0.44 10.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDN05310.1 - 0.00012 22.4 0.2 0.042 14.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EDN05310.1 - 0.00016 21.9 4.0 0.67 10.2 0.5 4.0 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EDN05310.1 - 0.0002 21.2 0.0 0.00046 20.0 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EDN05310.1 - 0.00085 18.7 0.0 0.015 14.6 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 EDN05310.1 - 0.0011 19.3 0.4 0.0047 17.3 0.1 2.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_28 PF13521.6 EDN05310.1 - 0.0018 18.5 0.0 0.0032 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EDN05310.1 - 0.016 15.7 0.5 6.7 7.2 0.1 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EDN05310.1 - 0.017 14.9 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN05310.1 - 0.026 14.5 0.0 0.081 12.8 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase IBN_N PF03810.19 EDN05310.1 - 0.098 12.6 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 Importin-beta N-terminal domain Fungal_trans PF04082.18 EDN05311.1 - 1.6e-10 40.5 0.2 4.3e-10 39.1 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain c-SKI_SMAD_bind PF08782.10 EDN05311.1 - 0.2 11.9 2.7 26 5.1 1.8 2.8 2 0 0 2 2 2 0 c-SKI Smad4 binding domain TRAM_LAG1_CLN8 PF03798.16 EDN05312.1 - 3.4e-29 102.0 16.9 3.4e-29 102.0 16.9 1.6 1 1 1 2 2 2 1 TLC domain TRAM1 PF08390.11 EDN05312.1 - 1.1e-17 63.4 1.4 2.1e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 TRAM1-like protein DUF2973 PF11189.8 EDN05312.1 - 0.019 15.0 0.0 1.1 9.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2973) DUF4834 PF16118.5 EDN05312.1 - 0.29 12.1 0.5 1.6 9.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) 4F5 PF04419.14 EDN05314.1 - 3.4e-11 43.8 12.9 3.4e-11 43.8 12.9 2.4 2 1 0 2 2 2 1 4F5 protein family CDPS PF16715.5 EDN05314.1 - 0.67 9.6 6.8 0.72 9.5 6.8 1.1 1 0 0 1 1 1 0 Cyclodipeptide synthase CHD5 PF04420.14 EDN05316.1 - 5.4e-60 201.9 1.3 6.5e-60 201.6 1.3 1.1 1 0 0 1 1 1 1 CHD5-like protein WXG100 PF06013.12 EDN05316.1 - 0.076 13.3 1.1 0.12 12.6 1.1 1.3 1 0 0 1 1 1 0 Proteins of 100 residues with WXG EVI2A PF05399.11 EDN05318.1 - 1.8 8.1 7.6 1.9 8.0 7.6 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) RRM_1 PF00076.22 EDN05319.1 - 3.3e-06 26.8 0.0 6.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPT6_acidic PF14632.6 EDN05319.1 - 0.48 11.0 11.8 1.2 9.7 7.3 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 AftA_N PF12250.8 EDN05322.1 - 0.028 13.2 0.9 0.029 13.1 0.9 1.0 1 0 0 1 1 1 0 Arabinofuranosyltransferase N terminal R-HINP1I PF11463.8 EDN05322.1 - 0.048 13.1 0.2 0.048 13.1 0.2 1.0 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease CENP-N PF05238.13 EDN05324.1 - 1.1e-60 206.2 0.0 1.2e-60 206.0 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like DUF5586 PF17824.1 EDN05324.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5586) zf-RING_2 PF13639.6 EDN05325.1 - 9.6e-07 29.0 5.7 9.6e-07 29.0 5.7 1.9 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EDN05325.1 - 2.8e-05 24.1 1.7 2.8e-05 24.1 1.7 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger SWIM PF04434.17 EDN05325.1 - 6.2e-05 22.6 0.2 0.00012 21.6 0.2 1.5 1 0 0 1 1 1 1 SWIM zinc finger Prok-RING_1 PF14446.6 EDN05325.1 - 0.00017 21.4 3.4 0.00028 20.7 1.2 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.6 EDN05325.1 - 0.024 14.6 3.3 0.069 13.2 3.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger PHD PF00628.29 EDN05325.1 - 0.03 14.2 5.0 0.12 12.3 5.2 1.9 1 1 1 2 2 2 0 PHD-finger zf-RING_4 PF14570.6 EDN05325.1 - 0.033 14.0 5.5 0.061 13.1 5.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDN05325.1 - 0.08 13.1 9.8 0.076 13.2 6.0 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.6 EDN05325.1 - 0.24 11.4 9.7 0.058 13.4 5.4 2.0 2 0 0 2 2 2 0 zinc-RING finger domain RINGv PF12906.7 EDN05325.1 - 5.3 7.2 12.9 0.47 10.6 8.2 1.7 2 0 0 2 2 2 0 RING-variant domain bZIP_2 PF07716.15 EDN05328.1 - 1.6e-13 50.5 12.8 2.4e-13 49.9 12.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDN05328.1 - 2e-05 24.6 10.5 2.9e-05 24.1 10.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor Phlebovirus_NSM PF07246.11 EDN05328.1 - 0.022 14.1 4.7 0.027 13.9 4.7 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M SOGA PF11365.8 EDN05328.1 - 0.035 15.2 2.1 0.051 14.7 2.1 1.3 1 0 0 1 1 1 0 Protein SOGA TSC22 PF01166.18 EDN05328.1 - 0.037 14.4 0.4 0.071 13.4 0.3 1.5 1 1 0 1 1 1 0 TSC-22/dip/bun family APC_u14 PF16635.5 EDN05328.1 - 0.064 13.8 2.7 0.086 13.4 2.7 1.2 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr CREPT PF16566.5 EDN05328.1 - 0.24 11.6 3.3 0.29 11.3 3.3 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4349 PF14257.6 EDN05328.1 - 0.58 9.6 5.5 0.12 11.8 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) BRO1 PF03097.18 EDN05329.1 - 3.5e-120 401.4 0.0 5.3e-120 400.8 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDN05329.1 - 1.4e-48 165.7 4.5 4.1e-48 164.2 4.5 1.8 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV GGA_N-GAT PF18308.1 EDN05329.1 - 1.3 8.7 4.7 25 4.6 0.1 3.5 3 0 0 3 3 3 0 GGA N-GAT domain SelP_N PF04592.14 EDN05329.1 - 7.9 5.8 12.4 0.77 9.1 7.4 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Mito_carr PF00153.27 EDN05330.1 - 2.4e-35 120.3 18.5 3.7e-15 55.6 0.2 4.3 4 1 0 4 4 4 3 Mitochondrial carrier protein TFIIA PF03153.13 EDN05330.1 - 0.87 9.5 12.9 1.2 9.0 12.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 EDN05330.1 - 1.2 8.0 18.1 0.077 12.0 11.4 2.3 3 0 0 3 3 3 0 Transcriptional activator LAG-3 Spt20 PF12090.8 EDN05330.1 - 1.9 8.0 16.8 3.2 7.3 16.8 1.3 1 0 0 1 1 1 0 Spt20 family GREB1 PF15782.5 EDN05330.1 - 4.3 4.3 10.5 5.9 3.9 10.5 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SUIM_assoc PF16619.5 EDN05330.1 - 8.9 6.5 17.1 23 5.1 17.1 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Thiolase_N PF00108.23 EDN05331.1 - 9.4e-14 51.4 0.3 3.9e-12 46.1 0.1 2.6 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN05331.1 - 2.1e-11 43.6 2.3 5.7e-11 42.1 0.5 2.5 2 1 1 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EDN05331.1 - 1.6e-06 27.9 0.1 7.9e-05 22.4 0.0 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EDN05331.1 - 0.0031 17.1 1.2 0.0071 16.0 0.7 1.8 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EDN05331.1 - 0.086 12.9 0.3 1.5 8.9 0.3 2.6 1 1 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain DUF974 PF06159.13 EDN05332.1 - 7.9e-35 120.8 0.0 9.4e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) DDE_3 PF13358.6 EDN05333.1 - 8.2e-08 32.1 0.8 9.1e-08 32.0 0.8 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DENN PF02141.21 EDN05334.1 - 2.4e-44 151.5 0.0 3.2e-31 108.7 0.2 2.5 1 1 1 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 EDN05334.1 - 8.2e-16 58.5 1.2 1.2e-15 58.0 0.0 2.0 2 0 0 2 2 2 1 uDENN domain HATPase_c_3 PF13589.6 EDN05338.1 - 7.9e-25 87.3 0.0 1.4e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EDN05338.1 - 2.6e-10 40.2 0.0 1e-08 35.1 0.0 2.3 2 0 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 EDN05338.1 - 0.00034 21.1 0.0 0.00073 20.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RasGEF PF00617.19 EDN05339.1 - 3e-53 180.6 0.1 5e-53 179.9 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDN05339.1 - 7e-16 58.4 0.0 2.5e-15 56.6 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif MARVEL PF01284.23 EDN05340.1 - 0.1 12.6 1.3 0.1 12.6 1.3 1.0 1 0 0 1 1 1 0 Membrane-associating domain Apis_Csd PF11671.8 EDN05340.1 - 4 7.4 14.8 4 7.4 14.8 1.1 1 0 0 1 1 1 0 Complementary sex determiner protein DUF4064 PF13273.6 EDN05342.1 - 0.0086 16.3 1.0 0.011 16.0 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF4231 PF14015.6 EDN05342.1 - 0.095 13.2 0.9 0.12 12.9 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Pox_EPC_I2-L1 PF12575.8 EDN05342.1 - 0.12 12.6 1.7 0.36 11.1 0.6 1.9 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Insulin_TMD PF17870.1 EDN05342.1 - 0.17 12.0 2.2 3.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment UL41A PF17591.2 EDN05342.1 - 1.1 9.4 4.0 1.1 9.4 0.1 2.0 1 1 1 2 2 2 0 Herpesvirus UL41A CLPTM1 PF05602.12 EDN05343.1 - 0.058 12.4 0.1 0.074 12.1 0.1 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Helicase_C PF00271.31 EDN05346.1 - 3.8e-14 53.0 0.1 8.1e-14 51.9 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF573 PF04504.14 EDN05347.1 - 2.7e-06 27.9 0.1 5.7e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN05347.1 - 4e-05 23.7 0.4 7.6e-05 22.8 0.4 1.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05347.1 - 0.0043 17.3 0.1 0.0073 16.5 0.1 1.5 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN05347.1 - 0.0085 16.5 2.5 0.12 12.8 2.5 2.1 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain EndoU_bacteria PF14436.6 EDN05348.1 - 0.68 10.3 2.1 2.4 8.5 0.0 2.5 1 1 1 3 3 3 0 Bacterial EndoU nuclease Ntox46 PF15538.6 EDN05348.1 - 0.76 9.7 3.6 2.2 8.2 0.2 3.1 1 1 2 3 3 3 0 Bacterial toxin 46 DUF2200 PF09966.9 EDN05350.1 - 0.013 15.6 0.2 0.091 12.9 0.2 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) OrsD PF12013.8 EDN05355.1 - 4.7e-10 39.9 2.7 5.1e-10 39.8 0.1 2.1 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D SCAN PF02023.17 EDN05359.1 - 0.057 13.2 0.8 0.12 12.2 0.4 1.7 2 0 0 2 2 2 0 SCAN domain Exo_endo_phos_2 PF14529.6 EDN05360.1 - 1.8e-12 47.1 0.0 6e-12 45.5 0.0 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 EDN05360.1 - 0.00043 19.9 0.0 0.00071 19.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ORF_12_N PF18042.1 EDN05360.1 - 0.023 15.1 0.8 0.12 12.8 0.5 2.3 3 0 0 3 3 3 0 ORF 12 gene product N-terminal RNase_H PF00075.24 EDN05360.1 - 0.061 13.5 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 RNase H PDU_like PF15953.5 EDN05361.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative propanediol utilisation DUF3435 PF11917.8 EDN05363.1 - 5.1e-154 513.2 0.1 8e-154 512.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN05363.1 - 3.4e-05 23.7 0.0 0.0013 18.6 0.0 2.4 2 0 0 2 2 2 1 Phage integrase family Jnk-SapK_ap_N PF09744.9 EDN05363.1 - 0.93 9.7 13.5 0.046 13.9 3.0 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Aldedh PF00171.22 EDN05364.1 - 3.6e-101 338.9 0.0 4.4e-101 338.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sigma70_r4 PF04545.16 EDN05364.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Pro_dh PF01619.18 EDN05365.1 - 6.8e-50 170.3 1.8 1.1e-49 169.5 1.8 1.3 1 1 0 1 1 1 1 Proline dehydrogenase AP_endonuc_2 PF01261.24 EDN05365.1 - 0.015 14.8 0.1 0.038 13.4 0.1 1.9 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Wyosine_form PF08608.12 EDN05367.1 - 2e-22 79.3 0.0 5.5e-22 77.9 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EDN05367.1 - 4.4e-22 79.2 0.0 1.2e-21 77.8 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EDN05367.1 - 1.5e-09 38.2 0.1 7.1e-08 32.8 0.1 2.4 1 1 0 1 1 1 1 Flavodoxin DDE_1 PF03184.19 EDN05368.1 - 3.3e-31 108.3 0.0 7.3e-31 107.2 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05368.1 - 8.3e-06 25.7 0.0 2.4e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN05368.1 - 9e-05 22.3 0.1 0.004 16.9 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease Smg4_UPF3 PF03467.15 EDN05369.1 - 5.1e-36 124.3 0.0 5.1e-36 124.3 0.0 2.2 2 1 0 2 2 2 1 Smg-4/UPF3 family RRM_1 PF00076.22 EDN05369.1 - 6.1e-07 29.2 0.0 3.7e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDN05369.1 - 0.21 11.6 0.0 0.43 10.6 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif hDGE_amylase PF14701.6 EDN05369.1 - 6.4 5.7 5.1 0.62 9.1 0.7 1.4 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain RVT_2 PF07727.14 EDN05370.1 - 3.3e-38 131.7 0.0 5.4e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN05370.1 - 0.028 14.6 0.0 0.071 13.3 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 EDN05371.1 - 9.5e-34 116.8 0.0 5.1e-33 114.4 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN05371.1 - 3.9e-11 43.3 0.0 9.1e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN05371.1 - 8.6e-10 38.5 0.0 2.6e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN05371.1 - 0.068 13.6 0.7 0.32 11.5 0.5 2.3 2 0 0 2 2 2 0 ORF 12 gene product N-terminal ABM PF03992.16 EDN05372.1 - 0.00027 21.0 2.6 0.00052 20.1 1.8 2.0 1 1 1 2 2 2 1 Antibiotic biosynthesis monooxygenase Nexin_C PF08628.12 EDN05373.1 - 0.033 14.8 0.4 0.057 14.0 0.4 1.3 1 0 0 1 1 1 0 Sorting nexin C terminal RVT_1 PF00078.27 EDN05374.1 - 2.9e-33 115.2 0.0 5.2e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN05374.1 - 1.1e-11 44.7 0.0 2.6e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN05374.1 - 3.8e-11 43.4 0.0 9.2e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN05374.1 - 0.063 13.7 0.6 0.29 11.6 0.4 2.3 2 0 0 2 2 2 0 ORF 12 gene product N-terminal DDE_1 PF03184.19 EDN05375.1 - 0.11 12.2 0.0 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 DDE superfamily endonuclease CAP_N PF01213.19 EDN05376.1 - 0.03 13.8 1.8 0.039 13.4 1.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RVT_1 PF00078.27 EDN05377.1 - 1.1e-40 139.5 0.0 1.6e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN05377.1 - 1e-13 51.1 0.0 3.7e-13 49.4 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN05377.1 - 0.00018 21.1 0.0 0.00036 20.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Porph_ging PF09697.10 EDN05378.1 - 0.11 13.1 0.0 0.12 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (Porph_ging) VHS PF00790.19 EDN05379.1 - 4.4e-31 107.6 0.5 8.5e-31 106.7 0.5 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EDN05379.1 - 5.3e-18 64.4 0.1 7e-17 60.8 0.0 2.5 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDN05379.1 - 2.6e-15 56.0 0.1 5.6e-15 54.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDN05379.1 - 4.4e-13 48.7 0.0 1e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EDN05379.1 - 5.5e-10 39.4 3.2 1.2e-09 38.4 1.0 2.4 2 0 0 2 2 2 1 GAT domain UIM PF02809.20 EDN05379.1 - 0.063 13.2 1.2 0.15 12.1 1.2 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif Pkinase PF00069.25 EDN05380.1 - 1.4e-71 240.9 0.0 2e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05380.1 - 1.9e-45 155.2 0.0 2.8e-45 154.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDN05380.1 - 3.5e-21 75.3 0.1 1.2e-20 73.7 0.1 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EDN05380.1 - 4.8e-07 28.9 0.9 2e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDN05380.1 - 7e-07 28.8 0.0 1.3e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DSHCT PF08148.12 EDN05380.1 - 0.062 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Haspin_kinase PF12330.8 EDN05380.1 - 0.072 12.0 0.6 0.36 9.7 0.6 2.1 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EDN05380.1 - 0.1 12.0 0.5 0.2 11.0 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN05380.1 - 3.7 7.4 6.8 0.33 10.9 0.1 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family KH_1 PF00013.29 EDN05381.1 - 8.8e-85 278.5 30.8 9.4e-13 47.8 0.2 13.4 14 2 0 14 14 14 9 KH domain SLS PF14611.6 EDN05381.1 - 5.6e-11 42.7 8.4 0.023 14.5 0.0 7.6 5 2 2 8 8 8 3 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EDN05381.1 - 1.7e-09 37.4 21.2 0.018 14.9 0.9 7.5 7 1 1 8 8 8 3 KH domain KH_4 PF13083.6 EDN05381.1 - 0.011 15.6 1.2 13 5.7 0.0 5.1 6 0 0 6 6 6 0 KH domain DUF1664 PF07889.12 EDN05381.1 - 0.063 13.3 0.1 0.24 11.4 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4974 PF16344.5 EDN05381.1 - 0.23 11.5 1.1 32 4.6 0.0 3.7 5 0 0 5 5 5 0 Domain of unknown function (DUF4974) Rib_recp_KP_reg PF05104.12 EDN05381.1 - 1 10.4 5.9 2.6 9.1 5.9 1.6 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region APG5 PF04106.12 EDN05382.1 - 0.01 15.4 0.3 0.016 14.8 0.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg5 Nucleo_P87 PF07267.11 EDN05382.1 - 0.078 11.8 8.5 0.53 9.1 4.7 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 S-AdoMet_synt_C PF02773.16 EDN05382.1 - 0.17 11.8 0.2 0.35 10.9 0.2 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain UCH_1 PF13423.6 EDN05383.1 - 2.8e-99 332.7 0.5 3.9e-99 332.3 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EDN05383.1 - 6e-14 52.9 0.0 3.6e-13 50.4 0.0 2.2 1 1 0 1 1 1 1 Exonuclease UCH PF00443.29 EDN05383.1 - 1.6e-05 24.5 0.0 6.1e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase 2-Hacid_dh_C PF02826.19 EDN05384.1 - 6.3e-55 185.3 0.0 1.3e-54 184.2 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN05384.1 - 1.3e-36 125.2 0.0 1e-35 122.3 0.0 2.3 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EDN05384.1 - 0.00056 20.4 0.0 0.0016 18.9 0.0 1.8 1 0 0 1 1 1 1 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 EDN05384.1 - 0.0077 16.3 0.2 0.027 14.5 0.0 1.9 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AlaDh_PNT_C PF01262.21 EDN05384.1 - 0.067 12.5 2.8 0.53 9.5 2.8 2.2 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ACT PF01842.25 EDN05384.1 - 0.48 10.2 2.1 3.4 7.5 0.0 3.1 4 0 0 4 4 4 0 ACT domain Fe-ADH PF00465.19 EDN05385.1 - 2.6e-100 335.8 0.0 3.4e-100 335.4 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EDN05385.1 - 1.3e-12 48.0 0.2 2.9e-08 33.7 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EDN05385.1 - 0.097 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Glyoxalase PF00903.25 EDN05386.1 - 4.9e-33 114.1 0.0 2e-17 63.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDN05386.1 - 5.4e-11 42.7 0.0 0.00093 19.4 0.0 3.5 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EDN05386.1 - 6.9e-06 26.8 0.0 0.018 15.8 0.0 3.0 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EDN05386.1 - 0.0043 17.2 0.0 0.21 11.7 0.0 2.5 1 1 0 2 2 2 1 Glyoxalase-like domain MoaF PF10703.9 EDN05386.1 - 0.0044 16.9 0.0 0.24 11.3 0.0 2.4 2 0 0 2 2 2 1 MoaF N-terminal domain Glyoxalase_2 PF12681.7 EDN05386.1 - 0.025 14.5 0.6 4.7 7.2 0.0 3.1 4 0 0 4 4 4 0 Glyoxalase-like domain PBP-Tp47_a PF14889.6 EDN05386.1 - 0.081 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a IZUMO PF15005.6 EDN05388.1 - 0.076 13.5 0.3 0.22 12.0 0.2 1.7 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Arrestin_N PF00339.29 EDN05389.1 - 2.2e-11 44.0 0.0 4e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EDN05389.1 - 0.00069 20.1 0.0 0.0015 19.0 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 EDN05389.1 - 0.0031 17.2 0.0 0.0081 15.9 0.0 1.7 1 0 0 1 1 1 1 Arrestin_N terminal like APH PF01636.23 EDN05390.1 - 5e-12 46.3 0.0 9.3e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN05390.1 - 0.015 14.6 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 EDN05390.1 - 0.038 13.6 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase ANAPC4_WD40 PF12894.7 EDN05391.1 - 2.6e-10 40.4 0.0 0.0013 19.0 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN05391.1 - 2.6e-08 34.4 17.5 0.00011 22.9 0.2 5.7 5 1 0 5 5 5 2 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EDN05391.1 - 0.0038 15.8 0.0 0.0062 15.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain IKI3 PF04762.12 EDN05391.1 - 0.0053 14.8 0.0 0.0094 14.0 0.0 1.3 1 1 0 1 1 1 1 IKI3 family PD40 PF07676.12 EDN05391.1 - 0.0079 16.1 0.0 6.3 6.9 0.0 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EDN05391.1 - 0.017 15.0 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Utp8 PF10395.9 EDN05391.1 - 0.19 10.2 0.0 0.28 9.7 0.0 1.1 1 0 0 1 1 1 0 Utp8 family EF_assoc_2 PF08356.12 EDN05392.1 - 4.8e-34 116.2 0.0 9.6e-34 115.2 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EDN05392.1 - 2.4e-28 97.5 0.3 4.6e-28 96.6 0.3 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EDN05392.1 - 1.9e-24 86.1 0.0 5.6e-13 48.8 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EDN05392.1 - 6.3e-14 52.2 0.0 4.1e-08 33.5 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDN05392.1 - 2.6e-09 37.1 0.0 0.00034 20.7 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 EDN05392.1 - 8.6e-06 24.9 0.9 0.043 13.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EDN05392.1 - 1.6e-05 25.3 0.1 0.0051 17.2 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair AAA_16 PF13191.6 EDN05392.1 - 4.8e-05 23.8 0.1 0.13 12.6 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EDN05392.1 - 0.00018 21.2 0.3 0.13 12.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain EF-hand_6 PF13405.6 EDN05392.1 - 0.00018 21.1 2.4 0.049 13.6 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain Dynamin_N PF00350.23 EDN05392.1 - 0.00041 20.4 1.5 0.73 9.9 0.3 3.1 3 1 1 4 4 4 2 Dynamin family EF-hand_8 PF13833.6 EDN05392.1 - 0.0015 18.4 0.3 0.85 9.5 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair AAA_22 PF13401.6 EDN05392.1 - 0.0028 17.9 0.3 1.6 9.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDN05392.1 - 0.0049 17.1 0.0 2.9 8.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 EDN05392.1 - 0.01 15.8 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 EF-hand_10 PF14788.6 EDN05392.1 - 0.017 15.0 0.7 0.21 11.4 0.1 2.4 2 0 0 2 2 2 0 EF hand AAA_18 PF13238.6 EDN05392.1 - 0.019 15.5 0.8 2 9.0 0.1 2.8 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EDN05392.1 - 0.032 14.6 0.0 1.2 9.5 0.0 2.5 2 0 0 2 2 2 0 RNA helicase RsgA_GTPase PF03193.16 EDN05392.1 - 0.035 14.0 0.2 2.3 8.1 0.1 3.2 3 0 0 3 3 3 0 RsgA GTPase GTP_EFTU PF00009.27 EDN05392.1 - 0.044 13.3 0.0 31 4.0 0.1 3.1 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EDN05392.1 - 0.049 13.4 0.1 0.55 9.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain EF-hand_5 PF13202.6 EDN05392.1 - 0.093 12.3 2.9 5.7 6.6 0.1 2.6 2 0 0 2 2 2 0 EF hand AAA_33 PF13671.6 EDN05392.1 - 0.14 12.3 0.1 24 5.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 EDN05392.1 - 0.16 11.0 0.1 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 MCM P-loop domain FtsK_SpoIIIE PF01580.18 EDN05392.1 - 0.22 10.9 0.1 21 4.4 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EDN05392.1 - 0.23 12.0 0.0 12 6.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Ysc84 PF04366.12 EDN05393.1 - 1.7e-41 140.9 0.2 2.8e-41 140.3 0.2 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EDN05393.1 - 1.7e-13 49.9 0.4 3.7e-13 48.9 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EDN05393.1 - 4.8e-11 42.2 0.0 1.3e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDN05393.1 - 3.2e-10 39.7 0.0 7.6e-10 38.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Zds_C PF08632.10 EDN05394.1 - 2.1e-29 101.0 0.4 3.9e-29 100.2 0.4 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Spidroin_N PF16763.5 EDN05395.1 - 0.034 14.2 0.1 0.04 13.9 0.1 1.1 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term LYTB PF02401.18 EDN05395.1 - 0.052 12.8 0.1 0.06 12.6 0.1 1.1 1 0 0 1 1 1 0 LytB protein DUF3435 PF11917.8 EDN05396.1 - 3.6e-160 533.5 0.1 5e-160 533.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) PRIMA1 PF16101.5 EDN05396.1 - 0.94 9.5 3.3 1.7 8.7 3.3 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EDN05396.1 - 3.5 7.0 6.0 0.73 9.3 1.7 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DUF5394 PF17372.2 EDN05396.1 - 9.2 5.8 8.9 8.6 5.8 5.1 2.6 2 1 2 4 4 4 0 Family of unknown function (DUF5394) SDA1 PF05285.12 EDN05398.1 - 1.3 8.4 4.4 1.5 8.2 4.4 1.1 1 0 0 1 1 1 0 SDA1 TFIIA PF03153.13 EDN05398.1 - 7.7 6.4 10.2 9.2 6.1 10.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ANAPC4_WD40 PF12894.7 EDN05401.1 - 0.00017 21.8 0.9 0.49 10.7 0.2 3.4 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN05401.1 - 0.11 13.5 5.2 2.3 9.2 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat GSH_synth_ATP PF03917.17 EDN05402.1 - 5.4e-131 436.8 0.0 6.2e-131 436.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EDN05402.1 - 2.5e-27 95.3 0.0 4.5e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase SNF2_N PF00176.23 EDN05403.1 - 2.5e-20 72.5 0.7 2.9e-14 52.6 0.0 2.9 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN05403.1 - 5e-18 65.5 0.2 1.9e-17 63.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDN05403.1 - 0.0016 17.7 0.0 0.0037 16.5 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SAM_2 PF07647.17 EDN05403.1 - 0.0018 18.3 0.1 0.0061 16.6 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EDN05403.1 - 0.021 15.0 0.0 0.076 13.3 0.0 1.9 1 0 0 1 1 1 0 Ste50p, sterile alpha motif ResIII PF04851.15 EDN05403.1 - 0.047 13.7 0.0 0.25 11.3 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EDN05404.1 - 4.9e-62 209.7 0.0 7.5e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EDN05404.1 - 1.4e-15 57.0 0.0 2.8e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EDN05404.1 - 2.2e-15 57.0 0.0 8.7e-15 55.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EDN05404.1 - 6e-11 42.0 8.3 1.7e-10 40.6 8.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN05404.1 - 1.5e-08 34.8 7.4 1.5e-08 34.8 7.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN05404.1 - 3.7e-08 33.1 8.9 3.7e-08 33.1 8.9 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN05404.1 - 6.2e-08 32.4 8.3 6.2e-08 32.4 8.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN05404.1 - 1.1e-07 31.8 5.2 3.2e-07 30.3 5.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EDN05404.1 - 1.3e-06 28.6 4.1 4e-06 27.0 4.1 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EDN05404.1 - 2.8e-05 23.7 2.5 2.8e-05 23.7 2.5 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 EDN05404.1 - 3.7e-05 23.6 6.2 3.7e-05 23.6 6.2 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDN05404.1 - 5e-05 23.4 7.5 5e-05 23.4 7.5 1.8 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING DEAD PF00270.29 EDN05404.1 - 0.00023 21.0 0.0 0.0005 19.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Prok-RING_4 PF14447.6 EDN05404.1 - 0.00055 19.7 8.7 0.0014 18.4 8.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EDN05404.1 - 0.00076 19.3 5.7 0.0021 17.9 5.7 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EDN05404.1 - 0.00097 19.3 0.3 0.0041 17.3 0.0 2.1 2 0 0 2 2 2 1 U-box domain zf-ANAPC11 PF12861.7 EDN05404.1 - 0.28 11.2 2.5 0.97 9.5 2.5 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EDN05404.1 - 4.6 7.1 6.1 12 5.8 6.1 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain MBOAT_2 PF13813.6 EDN05405.1 - 1.4e-23 82.9 4.2 1.4e-23 82.9 4.2 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family IncE PF17627.2 EDN05405.1 - 0.058 13.4 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Inclusion membrane protein E RIX1 PF08167.12 EDN05406.1 - 1.4e-53 181.4 2.6 1.8e-53 181.1 0.8 2.1 2 1 0 2 2 2 1 rRNA processing/ribosome biogenesis Terminase_6C PF17289.2 EDN05406.1 - 0.041 14.0 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 Terminase RNaseH-like domain TPR_8 PF13181.6 EDN05407.1 - 5.6e-07 29.3 6.3 0.065 13.5 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDN05407.1 - 7.7e-06 26.3 22.5 0.17 12.8 0.2 7.9 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDN05407.1 - 1.1e-05 25.2 15.1 0.22 11.7 0.1 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDN05407.1 - 0.00012 22.5 14.3 0.037 14.5 0.3 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDN05407.1 - 0.015 15.6 1.9 1.6 9.3 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDN05407.1 - 4.3 7.3 10.8 11 6.0 0.1 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDN05407.1 - 9.1 6.7 13.0 22 5.4 0.4 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat NDUFA12 PF05071.16 EDN05408.1 - 1.3e-31 109.3 1.7 1.6e-31 109.0 1.7 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 LTV PF04180.14 EDN05410.1 - 1.3e-93 314.8 1.2 9.6e-80 269.2 0.1 2.0 1 1 1 2 2 2 2 Low temperature viability protein MMR_HSR1 PF01926.23 EDN05412.1 - 6.6e-08 32.6 0.3 5.2e-06 26.5 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN05412.1 - 5.1e-05 22.9 1.0 0.0092 15.5 0.2 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDN05412.1 - 0.0008 19.3 1.3 0.23 11.3 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase cobW PF02492.19 EDN05412.1 - 0.01 15.5 0.8 0.043 13.4 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EDN05412.1 - 0.027 14.5 0.1 0.48 10.5 0.0 2.3 2 0 0 2 2 2 0 Dynamin family AIG1 PF04548.16 EDN05412.1 - 0.053 12.8 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 AIG1 family zf-C2H2 PF00096.26 EDN05413.1 - 0.11 13.0 13.5 0.14 12.7 0.4 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type Fungal_trans_2 PF11951.8 EDN05414.1 - 0.00079 18.3 0.9 0.0015 17.4 0.6 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Pkinase PF00069.25 EDN05416.1 - 2e-68 230.6 0.0 4.2e-68 229.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05416.1 - 1.2e-47 162.4 0.0 3e-47 161.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EDN05416.1 - 1.3e-26 92.8 0.0 2.4e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 EDN05416.1 - 3.5e-16 59.4 0.2 7.6e-16 58.3 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EDN05416.1 - 8.7e-13 48.2 0.1 2e-12 47.0 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EDN05416.1 - 8.3e-08 31.9 0.0 0.00053 19.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RA PF00788.23 EDN05416.1 - 0.0011 19.6 0.0 0.002 18.7 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Pkinase_fungal PF17667.1 EDN05416.1 - 0.0065 15.3 0.0 0.014 14.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase SAM_4 PF18017.1 EDN05416.1 - 0.021 14.8 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) MSA-2c PF12238.8 EDN05416.1 - 0.097 12.7 0.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Merozoite surface antigen 2c Kdo PF06293.14 EDN05416.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L5_C PF00673.21 EDN05417.1 - 5.6e-31 106.6 0.0 9.2e-31 105.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDN05417.1 - 7.9e-05 22.9 0.1 0.00017 21.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 UCH PF00443.29 EDN05418.1 - 2.2e-17 63.4 0.0 4.7e-17 62.3 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN05418.1 - 9e-15 55.1 0.0 8.4e-07 28.9 0.0 2.4 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pep3_Vps18 PF05131.14 EDN05419.1 - 7.9e-46 155.6 0.0 5.4e-45 152.8 0.0 2.2 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EDN05419.1 - 3.7e-07 30.1 6.9 0.00082 19.3 0.1 3.9 3 1 0 3 3 3 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 EDN05419.1 - 0.00043 19.8 0.3 0.00043 19.8 0.3 1.8 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EDN05419.1 - 0.0018 18.2 0.3 0.0018 18.2 0.3 1.7 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EDN05419.1 - 0.0019 17.9 4.3 0.0019 17.9 4.3 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDN05419.1 - 0.002 17.9 0.6 0.002 17.9 0.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN05419.1 - 0.01 16.2 0.5 0.01 16.2 0.5 2.0 2 0 0 2 2 2 0 Ring finger domain Vps39_2 PF10367.9 EDN05419.1 - 0.017 15.5 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-RING_UBOX PF13445.6 EDN05419.1 - 0.027 14.5 0.5 0.076 13.0 0.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger DUF2175 PF09943.9 EDN05419.1 - 0.042 14.1 0.4 0.15 12.3 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) RPN1_RPN2_N PF17781.1 EDN05419.1 - 0.066 12.6 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain PspA_IM30 PF04012.12 EDN05419.1 - 0.12 11.9 0.1 0.29 10.7 0.1 1.6 1 0 0 1 1 1 0 PspA/IM30 family zf-C3H2C3 PF17122.5 EDN05419.1 - 0.81 9.8 6.6 0.89 9.7 1.7 2.4 2 0 0 2 2 2 0 Zinc-finger zf-rbx1 PF12678.7 EDN05419.1 - 0.86 9.9 4.9 0.41 11.0 0.8 2.5 3 0 0 3 3 3 0 RING-H2 zinc finger domain RT_RNaseH_2 PF17919.1 EDN05421.1 - 0.0044 17.0 0.0 0.0075 16.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN05423.1 - 2.3e-21 76.3 0.0 3.4e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN05423.1 - 4.1e-12 46.5 0.0 8.2e-12 45.5 0.0 1.5 1 1 0 1 1 1 1 RNase H DDE_Tnp_1_7 PF13843.6 EDN05424.1 - 3.8e-13 49.5 1.5 1.2e-05 24.8 0.0 2.1 1 1 1 2 2 2 2 Transposase IS4 RVT_1 PF00078.27 EDN05425.1 - 5.3e-24 85.0 0.0 9.2e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN05425.1 - 7.5e-12 45.6 0.0 1.6e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 RNase H Myb_DNA-binding PF00249.31 EDN05426.1 - 0.00072 19.7 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05426.1 - 0.025 14.8 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain FTA2 PF13095.6 EDN05427.1 - 3.7e-12 46.4 0.0 5.6e-09 35.9 0.0 2.4 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase PF00069.25 EDN05427.1 - 2.4e-05 23.9 0.0 3.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN05427.1 - 0.0081 16.1 0.1 1.3 8.9 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDN05427.1 - 0.019 14.4 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EDN05427.1 - 0.042 12.9 0.0 0.057 12.5 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 GATase_4 PF13230.6 EDN05428.1 - 0.1 11.4 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Glutamine amidotransferases class-II DUF2788 PF10981.8 EDN05428.1 - 0.15 12.1 0.0 0.57 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2788) Cytochrom_C552 PF02335.15 EDN05429.1 - 0.0061 15.5 0.1 0.0076 15.2 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c552 HOOK PF05622.12 EDN05429.1 - 0.023 12.9 0.0 0.039 12.1 0.0 1.3 1 0 0 1 1 1 0 HOOK protein Zn_clus PF00172.18 EDN05431.1 - 1.1e-07 31.8 8.7 1.1e-07 31.8 8.7 2.2 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rnf-Nqr PF02508.14 EDN05431.1 - 0.32 10.9 6.1 0.086 12.8 0.3 2.3 1 1 1 2 2 2 0 Rnf-Nqr subunit, membrane protein 7TMR-DISM_7TM PF07695.11 EDN05431.1 - 0.63 9.9 11.6 0.16 11.8 1.4 2.8 2 1 0 3 3 3 0 7TM diverse intracellular signalling Lac_bphage_repr PF06543.12 EDN05433.1 - 0.22 11.6 1.3 0.5 10.4 1.3 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor Exo_endo_phos_2 PF14529.6 EDN05434.1 - 4.3e-05 23.3 0.1 0.0002 21.2 0.1 2.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 EDN05434.1 - 0.00014 21.4 0.0 0.00024 20.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PsbH PF00737.20 EDN05434.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein RNase_H PF00075.24 EDN05435.1 - 1.5e-12 47.9 0.0 3.1e-12 46.9 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN05435.1 - 0.052 13.3 0.0 0.26 11.1 0.1 2.1 2 1 0 2 2 2 0 Reverse transcriptase-like DUF573 PF04504.14 EDN05436.1 - 2.2e-06 28.2 0.1 3.9e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN05436.1 - 2.9e-05 24.1 0.4 5.8e-05 23.2 0.4 1.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05436.1 - 0.0033 17.7 0.1 0.0052 17.0 0.1 1.5 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN05436.1 - 0.0061 16.9 2.6 0.09 13.2 2.6 2.1 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 EDN05436.1 - 0.2 11.9 0.5 0.52 10.5 0.5 1.7 1 1 0 1 1 1 0 SANT/Myb-like domain of DAMP1 DUF5039 PF16442.5 EDN05437.1 - 0.036 13.6 0.2 0.062 12.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) AAA_26 PF13500.6 EDN05437.1 - 0.11 12.3 0.1 0.41 10.4 0.0 1.9 1 1 1 2 2 2 0 AAA domain RT_RNaseH PF17917.1 EDN05439.1 - 1e-37 128.6 0.0 1.6e-37 128.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN05439.1 - 4.7e-33 113.2 0.0 7.2e-33 112.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DnaJ PF00226.31 EDN05441.1 - 1e-19 70.4 1.3 1e-19 70.4 1.3 2.3 2 1 0 2 2 2 1 DnaJ domain TPR_19 PF14559.6 EDN05441.1 - 1.2e-05 25.7 1.1 3.1e-05 24.4 1.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDN05441.1 - 0.00055 19.7 2.4 0.0084 15.9 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN05441.1 - 0.00063 19.8 5.2 0.048 13.9 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDN05441.1 - 0.007 16.4 0.1 0.13 12.5 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN05441.1 - 0.044 14.0 9.0 0.26 11.5 0.6 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDN05441.1 - 0.11 12.6 0.2 0.9 9.7 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDN05441.1 - 0.12 12.9 0.9 7.7 7.2 0.1 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat KORA PF16509.5 EDN05441.1 - 0.14 12.5 0.5 0.53 10.6 0.3 2.1 2 1 0 2 2 2 0 TrfB plasmid transcriptional repressor TPR_7 PF13176.6 EDN05441.1 - 0.19 11.8 1.1 14 6.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Alpha_Helical PF18489.1 EDN05441.1 - 0.38 10.9 3.8 0.17 12.1 0.9 1.9 2 0 0 2 2 2 0 Alpha helical domain RF-1 PF00472.20 EDN05442.1 - 4.7e-34 116.8 0.6 4.7e-34 116.8 0.6 1.5 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.18 EDN05442.1 - 4.2e-10 39.8 2.9 4.2e-10 39.8 2.9 1.9 3 0 0 3 3 3 1 PCRF domain Mito_carr PF00153.27 EDN05443.1 - 5.2e-30 103.2 1.1 2.4e-19 69.1 0.3 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein AgrB PF04647.15 EDN05443.1 - 0.098 12.0 0.1 0.16 11.3 0.1 1.5 1 1 1 2 2 2 0 Accessory gene regulator B DEAD PF00270.29 EDN05444.1 - 2.2e-43 148.1 0.1 3.5e-43 147.4 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN05444.1 - 1.7e-28 99.2 0.9 6.1e-27 94.2 0.4 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN05444.1 - 0.0013 18.7 0.0 0.0029 17.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDN05444.1 - 0.022 14.1 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit API5 PF05918.11 EDN05444.1 - 0.23 10.2 7.1 0.35 9.6 7.1 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) RVT_1 PF00078.27 EDN05445.1 - 4.3e-37 127.8 0.0 6.5e-37 127.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN05445.1 - 2.9e-13 49.7 0.0 9.3e-13 48.1 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN05445.1 - 0.00018 21.1 0.1 0.00033 20.3 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN05445.1 - 2.3 8.5 8.7 1.1 9.4 4.8 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN05445.1 - 4.2 7.2 6.4 4.9 7.0 1.7 2.5 2 0 0 2 2 2 0 Zinc knuckle DUF3435 PF11917.8 EDN05446.1 - 1.5e-39 136.1 0.0 1.6e-38 132.7 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) RNase_H PF00075.24 EDN05447.1 - 1.8e-07 31.4 0.8 2.4e-07 31.0 0.1 1.6 2 0 0 2 2 2 1 RNase H POTRA_TamA_1 PF17243.2 EDN05447.1 - 0.2 11.8 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 POTRA domain TamA domain 1 FlxA PF14282.6 EDN05453.1 - 0.032 14.2 6.8 0.13 12.2 5.2 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF3375 PF11855.8 EDN05453.1 - 0.062 12.2 8.0 0.044 12.7 5.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) FUSC PF04632.12 EDN05453.1 - 2.8 6.4 3.8 3.6 6.0 3.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family RVP_2 PF08284.11 EDN05454.1 - 0.0072 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Urease_linker PF18473.1 EDN05454.1 - 0.25 11.2 1.0 0.55 10.2 1.0 1.5 1 0 0 1 1 1 0 Urease subunit beta-alpha linker domain Gly_transf_sug PF04488.15 EDN05456.1 - 1.5e-05 25.5 0.1 2.7e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EDN05456.1 - 0.0045 16.4 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein p450 PF00067.22 EDN05457.1 - 0.035 12.9 0.0 0.035 12.9 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 CX9C PF16860.5 EDN05458.1 - 0.017 15.1 1.7 0.049 13.6 0.2 2.1 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDN05458.1 - 0.14 12.3 0.7 0.22 11.7 0.7 1.3 1 0 0 1 1 1 0 CHCH domain RVT_2 PF07727.14 EDN05459.1 - 6.1e-12 45.7 0.0 8.9e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Flavodoxin_1 PF00258.25 EDN05462.1 - 7.3e-28 97.6 0.0 1.1e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin NIR_SIR_ferr PF03460.17 EDN05462.1 - 2.1e-14 53.1 0.0 5e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain DDE_Tnp_1_7 PF13843.6 EDN05463.1 - 8.9e-25 87.7 0.0 2.6e-13 50.0 0.0 2.0 1 1 1 2 2 2 2 Transposase IS4 RNase_H PF00075.24 EDN05465.1 - 1.1e-07 32.2 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN05465.1 - 0.14 11.9 0.1 0.49 10.2 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like Chromo PF00385.24 EDN05466.1 - 8.4e-06 25.6 0.2 1.8e-05 24.6 0.2 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA PF00004.29 EDN05468.1 - 1.6e-16 61.0 0.0 1.6e-15 57.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EDN05468.1 - 4.3e-13 49.7 3.4 6.6e-13 49.1 2.6 1.8 3 0 0 3 3 2 1 BCS1 N terminal RuvB_N PF05496.12 EDN05468.1 - 0.00019 21.2 0.0 0.0014 18.4 0.0 2.3 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDN05468.1 - 0.00053 20.4 0.0 0.0013 19.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EDN05468.1 - 0.0022 18.0 0.0 0.0059 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EDN05468.1 - 0.0027 18.0 0.2 0.008 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDN05468.1 - 0.0039 17.7 0.6 0.012 16.2 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDN05468.1 - 0.004 17.3 0.1 0.017 15.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EDN05468.1 - 0.0056 15.9 0.0 0.012 14.8 0.0 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 EDN05468.1 - 0.0094 15.1 0.0 0.027 13.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDN05468.1 - 0.012 15.9 0.1 0.076 13.3 0.0 2.3 1 1 1 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDN05468.1 - 0.047 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 EDN05468.1 - 0.048 14.2 0.1 0.15 12.6 0.1 2.0 1 1 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 EDN05468.1 - 0.048 13.0 0.1 0.28 10.5 0.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 EDN05468.1 - 0.1 13.0 0.3 0.33 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDN05468.1 - 0.16 12.4 0.1 0.45 10.9 0.1 1.9 1 1 0 1 1 1 0 RNA helicase RuvB_C PF05491.13 EDN05469.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain DUF2783 PF10932.8 EDN05470.1 - 0.013 15.2 0.1 0.037 13.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2783) DUF1664 PF07889.12 EDN05470.1 - 0.016 15.2 1.0 0.03 14.3 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) AKNA PF12443.8 EDN05470.1 - 0.15 12.7 3.3 0.48 11.1 0.2 2.6 2 1 1 3 3 3 0 AT-hook-containing transcription factor Spectrin PF00435.21 EDN05470.1 - 0.19 12.2 2.8 1.8 9.1 0.1 2.4 2 1 0 2 2 2 0 Spectrin repeat Med30 PF11315.8 EDN05470.1 - 0.29 11.3 2.4 4.6 7.4 1.4 2.6 1 1 1 2 2 2 0 Mediator complex subunit 30 RVT_1 PF00078.27 EDN05471.1 - 1.3e-31 109.8 0.0 2.3e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN05471.1 - 5.3e-12 46.1 0.0 3.3e-11 43.5 0.0 2.4 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 EDN05471.1 - 0.015 15.1 0.0 0.054 13.3 0.0 2.0 1 1 0 1 1 1 0 Reverse transcriptase-like Exo_endo_phos_2 PF14529.6 EDN05472.1 - 5.7e-11 42.3 0.2 1.8e-10 40.7 0.1 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN05472.1 - 0.036 13.6 0.1 0.053 13.0 0.1 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family HTH_33 PF13592.6 EDN05473.1 - 4.3e-06 26.3 0.0 2.3e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 EDN05473.1 - 0.0007 19.3 0.1 0.034 13.9 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EDN05473.1 - 0.015 15.3 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EDN05473.1 - 0.022 14.9 0.3 0.072 13.2 0.3 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HALZ PF02183.18 EDN05474.1 - 0.00015 21.9 0.2 0.00026 21.1 0.2 1.3 1 0 0 1 1 1 1 Homeobox associated leucine zipper Spc29 PF17082.5 EDN05474.1 - 0.0035 17.2 0.2 0.0061 16.4 0.2 1.4 1 0 0 1 1 1 1 Spindle Pole Component 29 ADIP PF11559.8 EDN05474.1 - 0.018 15.1 1.8 0.094 12.8 0.9 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EDN05474.1 - 0.027 14.7 1.0 0.027 14.7 1.0 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CCDC85 PF10226.9 EDN05474.1 - 0.033 13.9 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CCDC85 family Mod_r PF07200.13 EDN05474.1 - 0.049 13.7 0.2 0.089 12.9 0.2 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein bZIP_1 PF00170.21 EDN05474.1 - 0.07 13.2 0.5 0.14 12.3 0.5 1.5 1 0 0 1 1 1 0 bZIP transcription factor TSC22 PF01166.18 EDN05474.1 - 0.092 13.1 1.2 0.13 12.6 0.1 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family YabA PF06156.13 EDN05474.1 - 0.13 12.9 0.6 0.27 11.9 0.2 1.7 2 0 0 2 2 2 0 Initiation control protein YabA SlyX PF04102.12 EDN05474.1 - 0.33 11.6 1.7 1.6 9.4 1.7 2.1 1 1 0 1 1 1 0 SlyX Mpp10 PF04006.12 EDN05475.1 - 2.5e-17 62.6 19.4 3.7e-16 58.7 19.4 2.4 1 1 0 1 1 1 1 Mpp10 protein hNIFK_binding PF12196.8 EDN05475.1 - 1.7 8.2 5.2 1.2 8.7 0.8 2.9 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK SPX PF03105.19 EDN05477.1 - 3.2e-17 63.5 8.8 1.2e-05 25.4 0.6 3.0 1 1 2 3 3 3 3 SPX domain Rep-A_N PF04057.12 EDN05478.1 - 0.038 14.0 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Swm2 PF17083.5 EDN05478.1 - 0.041 13.9 0.2 0.055 13.5 0.2 1.1 1 0 0 1 1 1 0 Nucleolar protein Swm2 CFIA_Pcf11 PF11526.8 EDN05481.1 - 1.1e-12 48.3 1.9 2.5e-12 47.1 1.9 1.7 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 zf_UBZ PF18439.1 EDN05481.1 - 2.5 7.8 5.8 2.5 7.8 2.0 2.7 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-ISL3 PF14690.6 EDN05481.1 - 3.1 8.5 6.4 0.36 11.5 0.5 2.2 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 GFO_IDH_MocA PF01408.22 EDN05482.1 - 0.00012 22.9 0.0 0.00015 22.6 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ADK PF00406.22 EDN05485.1 - 1.2e-60 204.0 0.1 1.5e-60 203.6 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDN05485.1 - 3e-22 79.5 0.1 5.6e-22 78.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EDN05485.1 - 9.1e-18 64.0 0.0 2e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EDN05485.1 - 3.3e-05 24.4 0.0 5.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDN05485.1 - 0.0011 19.1 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDN05485.1 - 0.087 12.5 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain JAB PF01398.21 EDN05486.1 - 2.5e-30 104.9 0.0 7.1e-30 103.4 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDN05486.1 - 1.6e-21 76.8 0.1 3.6e-21 75.7 0.1 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function tRNA_bind_2 PF13725.6 EDN05486.1 - 0.12 12.0 6.0 0.18 11.5 6.0 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain Connexin PF00029.19 EDN05486.1 - 0.62 9.8 2.3 0.96 9.2 2.3 1.3 1 0 0 1 1 1 0 Connexin ANAPC_CDC26 PF10471.9 EDN05486.1 - 3.4 8.5 9.6 8 7.4 9.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 NAD_binding_4 PF07993.12 EDN05488.1 - 1e-69 234.6 0.0 1.8e-69 233.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EDN05488.1 - 4.5e-68 229.8 0.0 7.2e-68 229.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EDN05488.1 - 4.8e-10 39.3 0.0 1.1e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EDN05488.1 - 1.8e-09 37.8 0.0 3.9e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EDN05488.1 - 2.4e-06 26.7 0.0 5.9e-06 25.5 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 EDN05488.1 - 0.0001 23.2 0.0 0.00094 20.1 0.0 2.8 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 EDN05488.1 - 0.0057 16.1 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDN05488.1 - 0.13 11.4 0.0 0.28 10.3 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EDN05488.1 - 0.18 10.8 0.0 1 8.4 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain CAP_GLY PF01302.25 EDN05489.1 - 3.1e-25 88.0 0.0 6.5e-25 86.9 0.0 1.6 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EDN05489.1 - 1.7e-16 60.4 0.0 3e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EDN05489.1 - 1e-05 25.2 0.2 4.9e-05 23.0 0.0 2.1 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.8 EDN05489.1 - 0.17 11.7 0.2 0.94 9.3 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Trypan_PARP PF05887.11 EDN05490.1 - 2.9 7.9 26.0 16 5.5 26.0 2.1 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 EDN05491.1 - 2.6e-67 227.0 0.0 2.7e-58 197.4 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 EDN05491.1 - 6.4e-38 130.6 0.1 1.1e-35 123.3 0.9 2.1 2 0 0 2 2 2 2 Fungal protein kinase Pkinase_Tyr PF07714.17 EDN05491.1 - 4.6e-32 111.3 0.0 3.9e-28 98.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN05491.1 - 2.4e-06 26.7 0.1 3.6e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDN05491.1 - 0.00019 21.5 0.5 0.67 9.8 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN05491.1 - 0.0028 17.0 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDN05491.1 - 0.073 12.4 0.8 2.7 7.3 0.2 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SNF2_N PF00176.23 EDN05492.1 - 4.4e-16 58.5 0.3 5.7e-16 58.2 0.3 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain baeRF_family12 PF18856.1 EDN05492.1 - 0.0014 19.2 0.2 0.0023 18.5 0.2 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 12 DUF4449 PF14613.6 EDN05492.1 - 0.019 15.1 0.2 0.067 13.3 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) DUF573 PF04504.14 EDN05493.1 - 2.7e-06 27.9 0.1 5.7e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN05493.1 - 4e-05 23.7 0.4 7.6e-05 22.8 0.4 1.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05493.1 - 0.0043 17.3 0.1 0.0073 16.5 0.1 1.5 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN05493.1 - 0.0085 16.5 2.5 0.12 12.8 2.5 2.1 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain Retrotrans_gag PF03732.17 EDN05496.1 - 3.6e-05 24.0 1.7 3.6e-05 24.0 1.7 1.7 2 0 0 2 2 2 1 Retrotransposon gag protein Mac PF12464.8 EDN05496.1 - 0.11 12.8 0.9 0.27 11.5 0.9 1.6 1 0 0 1 1 1 0 Maltose acetyltransferase Helicase_C PF00271.31 EDN05497.1 - 1.6e-12 47.7 0.0 4.4e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OrsD PF12013.8 EDN05497.1 - 1e-05 25.9 0.8 3.7e-05 24.1 0.2 2.3 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EDN05500.1 - 1.5e-37 128.5 5.0 1.5e-37 128.5 5.0 2.3 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN05500.1 - 0.046 13.5 3.5 0.41 10.4 1.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DNA_primase_S PF01896.19 EDN05500.1 - 0.11 12.5 0.0 0.84 9.7 0.0 2.3 3 0 0 3 3 3 0 DNA primase small subunit DUF4298 PF14131.6 EDN05500.1 - 0.51 10.3 3.9 9.5 6.3 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) SLD5_C PF16922.5 EDN05501.1 - 0.027 14.7 0.1 0.038 14.2 0.1 1.4 1 1 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus DUF2200 PF09966.9 EDN05502.1 - 0.19 11.9 1.4 37 4.5 0.0 4.1 3 1 2 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2200) DUF573 PF04504.14 EDN05503.1 - 1.1e-05 26.0 0.1 3.5e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN05503.1 - 0.00012 22.2 0.1 0.00026 21.1 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05503.1 - 0.013 15.7 0.2 0.034 14.4 0.2 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN05503.1 - 0.043 14.2 2.2 0.44 11.0 2.2 2.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain CDC37_C PF08564.10 EDN05505.1 - 0.03 14.5 0.2 0.039 14.1 0.2 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain OrsD PF12013.8 EDN05506.1 - 7.9e-38 129.4 5.0 7.9e-38 129.4 5.0 2.3 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN05506.1 - 0.021 14.6 3.5 0.27 11.0 1.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Borrelia_P83 PF05262.11 EDN05506.1 - 5.7 5.3 9.3 2.8 6.3 2.1 2.0 2 0 0 2 2 2 0 Borrelia P83/100 protein Pribosyltran PF00156.27 EDN05509.1 - 2.2e-17 63.0 0.0 2.7e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDN05509.1 - 0.025 14.0 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Methyltr_RsmB-F PF01189.17 EDN05510.1 - 4.2e-16 59.2 0.1 7.9e-07 28.9 0.2 3.4 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Ferric_reduct PF01794.19 EDN05511.1 - 0.00068 19.8 3.8 0.00068 19.8 3.8 2.4 2 1 0 2 2 2 1 Ferric reductase like transmembrane component DUF998 PF06197.13 EDN05511.1 - 0.37 10.4 10.1 0.64 9.6 10.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF998) DUF4405 PF14358.6 EDN05511.1 - 5.9 7.5 10.2 0.47 11.0 4.6 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) Pkinase_fungal PF17667.1 EDN05512.1 - 1.6e-125 419.1 0.0 2e-125 418.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Caskin-Pro-rich PF16907.5 EDN05512.1 - 0.026 15.0 3.5 5.3 7.6 0.1 2.7 2 0 0 2 2 2 0 Proline rich region of Caskin proteins MauJ PF17419.2 EDN05512.1 - 0.18 11.2 0.0 0.37 10.2 0.0 1.4 1 0 0 1 1 1 0 Methylamine utilization protein MauJ Pkinase PF00069.25 EDN05513.1 - 1.8e-17 63.6 0.5 1.8e-16 60.3 0.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05513.1 - 7.8e-09 35.2 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDN05513.1 - 0.01 15.2 0.1 0.016 14.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EDN05513.1 - 0.02 13.9 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EDN05513.1 - 0.038 13.9 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDN05513.1 - 0.055 13.1 0.3 0.096 12.3 0.1 1.5 2 0 0 2 2 2 0 RIO1 family DDE_1 PF03184.19 EDN05516.1 - 9.4e-23 80.7 0.0 2.1e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN05516.1 - 8.6e-05 22.3 0.0 0.001 18.9 0.0 2.5 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05516.1 - 0.0018 18.3 0.0 0.0069 16.4 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN05516.1 - 0.03 14.0 0.5 0.03 14.0 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN05516.1 - 0.051 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) Borrelia_P83 PF05262.11 EDN05516.1 - 2.1 6.8 19.8 3.4 6.0 19.8 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein FAA_hydrolase PF01557.18 EDN05517.1 - 5.9e-54 183.0 0.0 8.4e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EDN05517.1 - 3e-31 107.8 0.0 4.8e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal GST_N_2 PF13409.6 EDN05518.1 - 5.2e-11 42.7 0.2 1.5e-10 41.2 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDN05518.1 - 1.2e-08 35.2 0.0 2.7e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EDN05518.1 - 1.9e-06 28.1 0.0 6.9e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDN05518.1 - 1.2e-05 25.5 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDN05518.1 - 0.0001 22.4 0.0 0.00018 21.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDN05518.1 - 0.00036 20.5 0.1 0.00099 19.1 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain HAD PF12710.7 EDN05519.1 - 1.7e-19 71.0 0.0 2.3e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN05519.1 - 4.5e-17 63.0 0.0 6.9e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDN05519.1 - 7.4e-09 35.7 0.1 2.7e-07 30.6 0.1 2.8 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDN05519.1 - 2.1e-06 27.9 0.0 4.1e-05 23.7 0.0 2.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EDN05519.1 - 6.1e-05 22.5 0.0 0.0077 15.7 0.0 2.1 2 0 0 2 2 2 2 Putative Phosphatase DUF705 PF05152.12 EDN05519.1 - 0.0094 15.5 0.1 0.014 14.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF705) S6PP PF05116.13 EDN05519.1 - 0.025 14.1 0.1 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase RVT_2 PF07727.14 EDN05520.1 - 8.5e-44 150.0 0.0 1.2e-43 149.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Semialdhyde_dhC PF02774.18 EDN05521.1 - 2.3e-32 112.6 0.0 3.5e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EDN05521.1 - 1.8e-24 86.5 0.0 3.1e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DUF739 PF05339.11 EDN05521.1 - 0.21 11.8 0.0 0.44 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF739) GCV_T PF01571.21 EDN05522.1 - 5e-72 242.4 0.0 6.4e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EDN05522.1 - 2.9e-16 59.1 0.2 5.6e-16 58.2 0.2 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Glyco_hydro_71 PF03659.14 EDN05523.1 - 1.5e-138 461.7 0.7 1.7e-138 461.5 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 hGDE_central PF14702.6 EDN05523.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme NDC10_II PF16787.5 EDN05524.1 - 1.8e-55 188.2 3.9 4.6e-34 117.9 0.0 2.6 2 1 1 3 3 3 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN05524.1 - 2.5e-18 66.2 0.0 1.3e-17 63.9 0.0 2.3 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DUF3716 PF12511.8 EDN05524.1 - 0.055 13.5 13.2 0.19 11.8 13.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) SAP18 PF06487.12 EDN05528.1 - 8.3e-50 168.6 0.0 1e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Prp18 PF02840.15 EDN05529.1 - 2.9e-56 189.5 0.0 2.9e-56 189.5 0.0 2.2 3 0 0 3 3 3 1 Prp18 domain PRP4 PF08799.11 EDN05529.1 - 2e-11 43.2 0.5 2e-11 43.2 0.5 2.6 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like SprA-related PF12118.8 EDN05529.1 - 1.5 7.8 11.7 2.9 7.0 11.7 1.4 1 0 0 1 1 1 0 SprA-related family Presenilin PF01080.17 EDN05529.1 - 3.4 6.3 10.1 5.6 5.6 10.1 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EDN05529.1 - 7 4.8 12.0 9.5 4.4 12.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Pyr_redox_3 PF13738.6 EDN05530.1 - 0.00038 19.8 0.0 0.00065 19.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN05530.1 - 0.12 12.4 0.1 0.87 9.6 0.0 2.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding Arf PF00025.21 EDN05531.1 - 1.2e-29 103.0 0.0 1.1e-16 60.8 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EDN05531.1 - 8.9e-07 29.1 0.0 3.4e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EDN05531.1 - 5.7e-06 25.7 0.0 9.6e-06 25.0 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Ras PF00071.22 EDN05531.1 - 6.3e-05 22.6 0.0 0.052 13.1 0.0 2.2 2 0 0 2 2 2 2 Ras family GTP_EFTU PF00009.27 EDN05531.1 - 0.003 17.1 0.0 0.0057 16.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN05531.1 - 0.0089 15.4 0.0 0.013 14.9 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region PIGA PF08288.12 EDN05532.1 - 5.2e-47 158.4 4.4 9.7e-47 157.5 1.5 2.3 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EDN05532.1 - 8e-29 100.8 0.3 1.3e-28 100.1 0.3 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EDN05532.1 - 2.9e-28 98.5 0.0 4.5e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDN05532.1 - 1.8e-25 89.9 0.1 3.6e-25 89.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EDN05532.1 - 1.9e-11 44.7 0.0 3.1e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EDN05532.1 - 8.4e-06 25.9 0.1 1.8e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EDN05532.1 - 0.0005 20.4 0.0 0.0019 18.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 DEAD PF00270.29 EDN05533.1 - 4e-32 111.4 0.0 2.3e-15 56.8 0.0 2.6 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN05533.1 - 1e-20 74.1 0.0 2.2e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN05533.1 - 3.1e-07 30.6 0.0 8.2e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ATG11 PF10377.9 EDN05533.1 - 0.065 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Autophagy-related protein 11 SAT PF16073.5 EDN05534.1 - 0.15 11.8 0.1 0.36 10.5 0.0 1.6 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Kelch_5 PF13854.6 EDN05536.1 - 8.7e-14 51.1 2.0 1.2e-12 47.5 2.7 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 EDN05536.1 - 0.013 15.8 1.3 0.31 11.4 0.4 3.0 3 0 0 3 3 3 0 Kelch motif OCC1 PF15506.6 EDN05536.1 - 0.1 12.7 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 OCC1 family Dscam_C PF12355.8 EDN05536.1 - 2.9 8.9 8.9 0.84 10.6 4.3 2.3 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal GMC_oxred_N PF00732.19 EDN05538.1 - 8.1e-27 94.4 3.7 1.6e-21 76.9 0.2 2.2 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN05538.1 - 7.9e-26 91.3 0.8 2.4e-25 89.7 0.1 2.1 2 1 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDN05538.1 - 5.5e-07 29.0 0.0 8.2e-06 25.1 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EDN05538.1 - 5.6e-05 22.5 0.1 0.00038 19.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN05538.1 - 0.00021 20.7 0.0 0.65 9.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN05538.1 - 0.0049 17.1 0.4 0.16 12.3 0.2 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EDN05538.1 - 0.022 14.1 0.4 0.03 13.7 0.4 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EDN05538.1 - 0.025 13.8 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EDN05538.1 - 0.05 12.8 0.1 0.13 11.5 0.1 1.6 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EDN05538.1 - 0.081 11.6 0.5 0.16 10.6 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 EDN05538.1 - 0.1 12.1 0.6 4.7 6.7 0.3 2.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDN05538.1 - 0.17 12.4 0.1 0.44 11.1 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FA_hydroxylase PF04116.13 EDN05539.1 - 2.7e-23 82.8 13.8 2.7e-23 82.8 13.8 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TCTP PF00838.17 EDN05540.1 - 1.3e-48 165.5 0.0 4.7e-48 163.7 0.0 1.7 1 1 0 1 1 1 1 Translationally controlled tumour protein FliE PF02049.18 EDN05540.1 - 0.08 13.1 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE Sod_Fe_N PF00081.22 EDN05540.1 - 0.12 12.9 0.1 0.22 12.0 0.1 1.4 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Fungal_trans PF04082.18 EDN05541.1 - 6.5e-14 51.6 0.0 1.4e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN05541.1 - 1.2e-08 34.9 10.1 2.4e-08 34.0 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SRP19 PF01922.17 EDN05542.1 - 1.1e-33 116.0 0.0 1.7e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein Mtc PF03820.17 EDN05543.1 - 2.5e-117 391.4 0.0 2.8e-117 391.2 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Pkinase PF00069.25 EDN05546.1 - 1.3e-48 165.7 0.0 2.5e-48 164.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05546.1 - 1.6e-18 66.9 0.0 6.4e-18 65.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase SpdB PF05122.13 EDN05547.1 - 0.12 12.5 1.1 1.3 9.2 0.1 2.3 2 0 0 2 2 2 0 Mobile element transfer protein TAF4 PF05236.14 EDN05548.1 - 5.5e-31 108.4 0.2 7.4e-24 85.0 1.4 2.2 2 0 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family CPSF73-100_C PF11718.8 EDN05549.1 - 9.1e-82 273.8 0.0 1.4e-81 273.2 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EDN05549.1 - 1.9e-30 105.4 0.0 4.8e-30 104.1 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EDN05549.1 - 4.4e-21 75.8 0.1 9.7e-21 74.7 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EDN05549.1 - 2.1e-16 59.9 0.1 3.6e-16 59.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EDN05549.1 - 1.1e-12 47.7 0.0 2.1e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EDN05549.1 - 1.3e-05 24.8 0.3 3.9e-05 23.3 0.2 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDN05549.1 - 1.3e-05 25.1 0.1 3.2e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain P_C PF06640.11 EDN05549.1 - 0.044 13.9 1.6 0.081 13.1 1.6 1.3 1 0 0 1 1 1 0 P protein C-terminus PHD PF00628.29 EDN05550.1 - 0.0082 16.0 1.8 0.015 15.1 1.8 1.4 1 0 0 1 1 1 1 PHD-finger DUF2293 PF10056.9 EDN05551.1 - 3.1e-24 85.0 0.0 6.4e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) BTB PF00651.31 EDN05552.1 - 3.2e-14 53.1 0.1 1.2e-13 51.3 0.1 2.1 1 1 0 1 1 1 1 BTB/POZ domain FcoT PF10862.8 EDN05552.1 - 0.0058 16.2 0.8 0.014 15.0 0.3 2.0 3 0 0 3 3 3 1 FcoT-like thioesterase domain Herpes_gI PF01688.17 EDN05552.1 - 0.0077 16.2 0.5 0.013 15.4 0.5 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein I DUF4758 PF15950.5 EDN05552.1 - 0.041 14.2 0.8 0.087 13.2 0.1 1.8 2 1 1 3 3 3 0 Putative sperm flagellar membrane protein DHR10 PF18595.1 EDN05552.1 - 0.079 13.0 1.8 0.16 12.1 1.8 1.5 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain RPE65 PF03055.15 EDN05553.1 - 1.7e-110 370.4 0.0 2e-110 370.2 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Dynamin_N PF00350.23 EDN05553.1 - 0.036 14.1 0.0 0.44 10.6 0.0 2.3 3 0 0 3 3 3 0 Dynamin family Acetyltransf_7 PF13508.7 EDN05554.1 - 8.2e-09 35.8 0.0 2.4e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN05554.1 - 4.3e-08 33.4 0.0 1.4e-07 31.8 0.0 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN05554.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDN05554.1 - 0.051 13.6 0.0 0.45 10.6 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain TruD PF01142.18 EDN05556.1 - 4e-61 207.1 0.0 1.1e-57 195.7 0.0 3.7 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) GMP_synt_C PF00958.22 EDN05557.1 - 3.5e-43 145.6 0.0 9.1e-43 144.2 0.0 1.8 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EDN05557.1 - 1.6e-37 129.2 0.0 2.9e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EDN05557.1 - 6.5e-12 45.1 0.2 1.4e-06 27.7 0.1 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EDN05557.1 - 1.2e-06 28.5 0.0 2.3e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EDN05557.1 - 0.00016 21.3 0.0 0.00057 19.4 0.0 1.8 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EDN05557.1 - 0.00063 18.6 0.1 0.0028 16.5 0.0 1.9 2 0 0 2 2 2 1 tRNA methyl transferase ThiI PF02568.14 EDN05557.1 - 0.0015 18.1 0.0 0.015 14.9 0.1 2.1 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 EDN05557.1 - 0.0098 16.0 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.19 EDN05557.1 - 0.02 14.2 0.0 0.045 13.1 0.1 1.5 2 0 0 2 2 2 0 Arginosuccinate synthase ATP_bind_3 PF01171.20 EDN05557.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 PP-loop family DDE_Tnp_1_7 PF13843.6 EDN05560.1 - 7.7e-25 87.9 0.1 1e-24 87.5 0.1 1.1 1 0 0 1 1 1 1 Transposase IS4 RVT_1 PF00078.27 EDN05561.1 - 6.7e-41 140.2 0.0 9.8e-41 139.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AbiEii PF08843.11 EDN05563.1 - 0.03 14.3 0.0 1 9.3 0.0 2.1 1 1 1 2 2 2 0 Nucleotidyl transferase AbiEii toxin, Type IV TA system DUF3663 PF12404.8 EDN05563.1 - 0.096 12.7 0.1 0.45 10.6 0.1 2.0 2 0 0 2 2 2 0 Peptidase MdcG PF10620.9 EDN05563.1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG NTP_transf_5 PF14907.6 EDN05563.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase Helo_like_N PF17111.5 EDN05564.1 - 8.7e-31 106.9 0.6 9.7e-31 106.8 0.6 1.0 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins FANCI_S2 PF14676.6 EDN05564.1 - 0.091 13.1 0.2 0.12 12.7 0.2 1.1 1 0 0 1 1 1 0 FANCI solenoid 2 DDE_Tnp_1_7 PF13843.6 EDN05565.1 - 1.8e-25 90.0 0.0 3.2e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Transposase IS4 ELO PF01151.18 EDN05566.1 - 1.6e-64 217.9 2.3 3.1e-51 174.3 2.4 2.1 2 0 0 2 2 2 2 GNS1/SUR4 family BCDHK_Adom3 PF10436.9 EDN05567.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase TBCC_N PF16752.5 EDN05567.1 - 0.14 12.6 0.2 0.29 11.6 0.2 1.4 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain ATP-synt_G PF04718.15 EDN05568.1 - 6.8e-31 107.1 0.1 1.3e-30 106.1 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Helicase_C PF00271.31 EDN05569.1 - 1.4e-24 86.6 0.0 2.4e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN05569.1 - 1.7e-07 31.2 0.0 2.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase UTP25 PF06862.12 EDN05569.1 - 0.041 12.6 0.0 3.2 6.4 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Methyltransf_16 PF10294.9 EDN05570.1 - 1.4e-21 77.0 0.0 2.8e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EDN05570.1 - 2.4e-06 27.5 0.0 9.3e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN05570.1 - 0.076 13.7 0.0 0.22 12.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain VPS28 PF03997.12 EDN05571.1 - 7.6e-74 247.5 0.2 8.9e-74 247.3 0.2 1.0 1 0 0 1 1 1 1 VPS28 protein Noc2 PF03715.13 EDN05572.1 - 1.7e-125 418.2 0.0 3.3e-125 417.3 0.0 1.5 1 0 0 1 1 1 1 Noc2p family HA PF03457.14 EDN05572.1 - 0.03 14.6 0.2 0.1 12.9 0.2 1.9 1 0 0 1 1 1 0 Helicase associated domain Transketolase_C PF02780.20 EDN05572.1 - 0.073 13.0 0.0 8.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Transketolase, C-terminal domain Rap1_C PF11626.8 EDN05572.1 - 4 7.6 6.1 4.1 7.6 1.2 3.0 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MoaC PF01967.21 EDN05573.1 - 9.4e-46 155.3 1.8 2.3e-45 154.0 1.8 1.7 1 1 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EDN05573.1 - 3e-37 127.4 0.0 2e-36 124.7 0.0 2.1 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EDN05573.1 - 1.9e-27 96.7 0.0 8.2e-27 94.6 0.1 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EDN05573.1 - 3.4e-05 24.2 0.0 6.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain ABC_tran PF00005.27 EDN05574.1 - 1.2e-34 119.8 4.4 6.1e-19 68.9 0.0 4.0 3 2 1 4 4 3 3 ABC transporter AAA_21 PF13304.6 EDN05574.1 - 5.6e-10 39.5 12.8 0.0023 17.8 0.1 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 EDN05574.1 - 3.8e-07 30.5 0.2 0.0012 19.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EDN05574.1 - 1.4e-06 28.0 0.7 0.0098 15.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EDN05574.1 - 1.9e-06 27.5 2.9 0.16 11.3 0.2 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 EDN05574.1 - 3.5e-06 26.9 3.3 3.5e-06 26.9 3.3 2.4 2 1 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 EDN05574.1 - 8.7e-06 26.3 0.0 0.1 13.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EDN05574.1 - 8.8e-06 25.8 0.3 0.15 12.2 0.0 3.0 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EDN05574.1 - 1.2e-05 25.9 5.5 0.011 16.3 1.1 2.9 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EDN05574.1 - 6.7e-05 22.9 0.0 0.055 13.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDN05574.1 - 7.6e-05 22.5 1.0 0.41 10.3 0.0 3.0 2 2 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EDN05574.1 - 8.8e-05 22.1 0.1 0.015 14.8 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 EDN05574.1 - 0.00011 22.7 0.0 0.33 11.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN05574.1 - 0.00021 21.7 0.0 0.14 12.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDN05574.1 - 0.00022 21.2 0.1 0.46 10.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_33 PF13671.6 EDN05574.1 - 0.00023 21.4 0.3 1.1 9.4 0.1 2.9 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 EDN05574.1 - 0.0003 20.6 0.5 0.075 12.7 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EDN05574.1 - 0.00064 19.2 0.9 0.52 9.6 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.6 EDN05574.1 - 0.00065 20.0 1.4 0.47 10.7 0.0 3.3 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDN05574.1 - 0.0012 19.2 0.1 0.27 11.6 0.0 2.7 2 1 0 2 2 2 1 RNA helicase NACHT PF05729.12 EDN05574.1 - 0.0014 18.6 0.3 1.6 8.6 0.2 2.6 2 0 0 2 2 2 2 NACHT domain MeaB PF03308.16 EDN05574.1 - 0.0022 17.0 2.1 1.3 7.9 0.0 3.0 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EDN05574.1 - 0.0048 16.8 0.2 0.93 9.4 0.2 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Thymidylate_kin PF02223.17 EDN05574.1 - 0.0049 16.6 0.0 2.6 7.7 0.0 2.7 2 0 0 2 2 2 1 Thymidylate kinase DUF87 PF01935.17 EDN05574.1 - 0.0051 16.9 3.8 1.3 9.0 0.1 2.9 3 0 0 3 3 2 2 Helicase HerA, central domain NB-ARC PF00931.22 EDN05574.1 - 0.0091 15.2 0.1 2.6 7.1 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Arf PF00025.21 EDN05574.1 - 0.013 15.0 0.2 0.51 9.8 0.1 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_24 PF13479.6 EDN05574.1 - 0.029 14.1 0.2 10 5.8 0.1 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDN05574.1 - 0.029 14.0 0.6 1.1 8.9 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 EDN05574.1 - 0.033 12.8 0.1 5.8 5.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EDN05574.1 - 0.033 13.8 0.0 7.3 6.2 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 EDN05574.1 - 0.035 14.1 0.6 0.8 9.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 EDN05574.1 - 0.05 13.5 0.7 11 5.9 0.0 3.2 4 0 0 4 4 3 0 NTPase Roc PF08477.13 EDN05574.1 - 0.076 13.2 0.0 20 5.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase T6PP_N PF18572.1 EDN05574.1 - 0.11 12.4 0.2 0.32 10.9 0.2 1.7 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain AAA_25 PF13481.6 EDN05574.1 - 0.12 11.9 0.1 18 4.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDN05574.1 - 0.18 11.8 0.1 27 4.8 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EDN05574.1 - 1.8 9.0 6.2 24 5.4 0.2 3.5 4 0 0 4 4 3 0 AAA domain RNase_H PF00075.24 EDN05577.1 - 0.002 18.3 0.4 0.0052 17.0 0.1 2.0 2 0 0 2 2 2 1 RNase H Rrp15p PF07890.12 EDN05577.1 - 0.01 16.1 0.6 0.029 14.7 0.0 1.9 2 0 0 2 2 2 0 Rrp15p DDE_Tnp_1_7 PF13843.6 EDN05578.1 - 1.3e-62 212.1 0.3 1.3e-36 126.6 0.0 2.2 2 0 0 2 2 2 2 Transposase IS4 APH PF01636.23 EDN05578.1 - 2.2e-07 31.1 0.0 0.013 15.5 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family FAP PF07174.11 EDN05578.1 - 1.1 8.6 14.2 1.9 7.9 14.2 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) RVT_1 PF00078.27 EDN05580.1 - 7.8e-35 120.4 0.0 1.4e-34 119.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN05580.1 - 4.5e-12 46.4 0.0 1.2e-11 45.0 0.0 1.8 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN05580.1 - 7.6e-10 38.7 0.0 2.7e-09 36.9 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN05580.1 - 0.068 13.6 0.5 0.26 11.7 0.5 2.0 1 0 0 1 1 1 0 ORF 12 gene product N-terminal ANAPC4_WD40 PF12894.7 EDN05582.1 - 2.5e-07 30.9 0.5 0.0003 21.0 0.0 4.2 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN05582.1 - 3.3e-07 30.9 0.4 0.097 13.6 0.0 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat IKI3 PF04762.12 EDN05582.1 - 0.002 16.3 0.0 0.0042 15.1 0.0 1.5 1 0 0 1 1 1 1 IKI3 family PD40 PF07676.12 EDN05582.1 - 0.0067 16.3 1.6 2.6 8.1 0.1 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Ribosomal_S25 PF03297.15 EDN05583.1 - 5.1e-40 135.8 4.7 5.6e-40 135.6 4.7 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_DeoR PF08220.12 EDN05583.1 - 0.014 15.2 0.1 0.019 14.7 0.1 1.2 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain MarR_2 PF12802.7 EDN05583.1 - 0.028 14.3 0.1 0.037 13.9 0.1 1.2 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.20 EDN05583.1 - 0.028 14.7 0.1 0.043 14.2 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_24 PF13412.6 EDN05583.1 - 0.038 13.6 0.1 0.057 13.0 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 EDN05583.1 - 0.042 13.8 0.1 0.059 13.3 0.1 1.3 1 0 0 1 1 1 0 HTH domain Cyt-b5 PF00173.28 EDN05584.1 - 9.4e-08 32.1 0.0 1.5e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ATP-grasp_4 PF13535.6 EDN05584.1 - 0.031 13.9 0.2 0.05 13.2 0.2 1.3 1 0 0 1 1 1 0 ATP-grasp domain Gtr1_RagA PF04670.12 EDN05585.1 - 1.7e-54 184.6 0.2 2.7e-54 184.0 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EDN05585.1 - 0.13 11.7 0.1 0.25 10.8 0.1 1.6 1 1 0 1 1 1 0 ADP-ribosylation factor family His_Phos_2 PF00328.22 EDN05586.1 - 2.6e-11 43.5 0.0 1.2e-09 38.0 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Methyltransf_23 PF13489.6 EDN05587.1 - 8.3e-22 77.8 0.0 1.3e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN05587.1 - 4.7e-14 52.9 0.0 1.6e-13 51.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN05587.1 - 4.9e-13 49.5 0.0 1.1e-12 48.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN05587.1 - 4e-09 36.5 0.0 0.00035 20.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDN05587.1 - 1.4e-08 35.4 0.0 1.7e-07 31.9 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN05587.1 - 5.8e-05 22.5 0.0 0.0004 19.8 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EDN05587.1 - 0.00097 18.9 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_4 PF02390.17 EDN05587.1 - 0.0055 16.2 0.0 0.021 14.3 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EDN05587.1 - 0.0062 16.1 0.0 0.024 14.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain PCMT PF01135.19 EDN05587.1 - 0.025 14.3 0.0 0.056 13.2 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EDN05587.1 - 0.031 13.7 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EDN05587.1 - 0.05 13.7 0.0 0.12 12.5 0.0 1.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase CMAS PF02353.20 EDN05587.1 - 0.1 11.9 0.0 0.23 10.7 0.0 1.6 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Aldo_ket_red PF00248.21 EDN05588.1 - 3.1e-33 115.2 0.0 9.2e-33 113.7 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1281_C PF18406.1 EDN05588.1 - 0.029 14.1 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Ferredoxin-like domain in Api92-like protein Rad51 PF08423.11 EDN05588.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad51 Lactamase_B_4 PF13691.6 EDN05589.1 - 3.5e-24 84.3 0.1 1.9e-23 81.9 0.0 2.2 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EDN05589.1 - 1.7e-14 53.9 0.2 5.6e-06 26.0 0.1 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDN05589.1 - 4.7e-05 23.5 2.3 0.00012 22.1 0.6 2.7 3 1 0 3 3 3 1 Metallo-beta-lactamase superfamily bZIP_1 PF00170.21 EDN05590.1 - 1.8e-08 34.4 9.9 4.4e-08 33.1 9.9 1.7 1 0 0 1 1 1 1 bZIP transcription factor Spt20 PF12090.8 EDN05590.1 - 0.0091 15.6 20.3 0.0091 15.6 20.3 2.7 3 0 0 3 3 3 1 Spt20 family APH PF01636.23 EDN05590.1 - 0.63 9.9 4.9 1.4 8.8 4.9 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Dus PF01207.17 EDN05592.1 - 2.9e-57 194.1 0.0 3.1e-56 190.8 0.0 2.3 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EDN05592.1 - 0.0061 15.8 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase GEN1_C PF18380.1 EDN05592.1 - 0.052 14.4 0.7 0.98 10.4 0.0 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain MIF PF01187.18 EDN05593.1 - 2.2e-07 31.1 0.1 4e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Macro PF01661.21 EDN05594.1 - 5e-11 42.7 0.0 3.5e-06 27.1 0.0 2.6 2 1 0 2 2 2 2 Macro domain Cu_bind_like PF02298.17 EDN05595.1 - 0.081 12.9 0.1 0.64 10.1 0.1 2.1 1 1 0 1 1 1 0 Plastocyanin-like domain Mis12 PF05859.12 EDN05596.1 - 3.8e-47 159.7 0.0 5.2e-47 159.3 0.0 1.2 1 0 0 1 1 1 1 Mis12 protein Ni_hydr_CYTB PF01292.20 EDN05597.1 - 0.019 14.6 0.7 0.063 12.9 0.0 1.9 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 BCNT PF07572.12 EDN05598.1 - 7.9e-26 89.9 0.2 1.9e-25 88.7 0.2 1.6 1 0 0 1 1 1 1 Bucentaur or craniofacial development DUF1168 PF06658.12 EDN05598.1 - 0.017 14.9 3.1 0.017 14.9 3.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1168) zf-C2H2 PF00096.26 EDN05599.1 - 7.2e-08 32.5 7.4 4.4e-05 23.7 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN05599.1 - 4.9e-07 29.9 2.2 4.9e-07 29.9 2.2 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN05599.1 - 4.1e-05 24.1 5.5 0.076 13.9 1.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EDN05599.1 - 0.14 12.8 3.9 4.3 8.0 0.1 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain Spt20 PF12090.8 EDN05600.1 - 9e-68 228.4 1.4 9e-68 228.4 1.4 6.7 3 2 2 6 6 6 1 Spt20 family Shadoo PF14999.6 EDN05601.1 - 6.6 6.8 12.8 0.32 11.1 5.3 2.6 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective Hexapep PF00132.24 EDN05602.1 - 6.9e-09 35.1 2.0 0.0021 17.7 1.1 2.8 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EDN05602.1 - 0.00051 19.1 2.0 0.0025 16.8 2.0 1.8 1 1 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 EDN05602.1 - 0.014 13.5 1.1 0.075 11.2 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) MFS_1 PF07690.16 EDN05605.1 - 2.7e-18 66.0 37.8 2.9e-10 39.6 21.4 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN05605.1 - 7.1e-11 41.6 13.7 1.9e-07 30.3 2.2 2.4 1 1 1 2 2 2 2 Sugar (and other) transporter 7TM-7TMR_HD PF07698.11 EDN05606.1 - 5.1 6.8 15.0 0.057 13.2 2.2 2.9 3 0 0 3 3 3 0 7TM receptor with intracellular HD hydrolase DUF3810 PF12725.7 EDN05606.1 - 7.1 5.9 5.9 1.9 7.8 2.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) PTR2 PF00854.21 EDN05607.1 - 1e-76 258.4 8.6 1.3e-76 258.0 8.6 1.2 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 EDN05607.1 - 1.6e-08 33.9 21.2 5.8e-06 25.5 9.0 2.9 3 0 0 3 3 3 2 Major Facilitator Superfamily EF-hand_9 PF14658.6 EDN05607.1 - 0.068 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Reticulon PF02453.17 EDN05607.1 - 0.84 9.6 4.1 13 5.7 0.1 2.7 2 0 0 2 2 2 0 Reticulon Glyco_hydro_31 PF01055.26 EDN05608.1 - 2.5e-148 494.9 1.0 3.9e-148 494.3 1.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EDN05608.1 - 7.4e-37 126.1 0.0 1.6e-36 125.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EDN05608.1 - 4e-14 52.7 2.5 1.3e-13 51.0 1.4 2.3 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EDN05608.1 - 0.044 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) BPL_LplA_LipB PF03099.19 EDN05609.1 - 0.00026 20.9 0.0 0.00062 19.7 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Amidohydro_2 PF04909.14 EDN05610.1 - 7.6e-24 85.0 0.0 9.1e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase DUF1580 PF07618.11 EDN05610.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) Fungal_trans PF04082.18 EDN05611.1 - 1.7e-26 92.8 1.0 1.7e-26 92.8 1.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN05611.1 - 1e-10 41.5 7.6 1.9e-10 40.7 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain tRNA-synt_2b PF00587.25 EDN05613.1 - 1.7e-34 119.3 0.0 2.8e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDN05613.1 - 2.3e-07 30.8 0.0 6.4e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain Fungal_trans PF04082.18 EDN05614.1 - 6e-08 32.0 0.5 1.8e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain ECH_1 PF00378.20 EDN05615.1 - 1.2e-36 126.4 0.0 2.5e-36 125.3 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN05615.1 - 8.4e-24 84.7 0.0 1.1e-23 84.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pyr_redox_2 PF07992.14 EDN05616.1 - 5e-56 190.1 0.2 8.6e-56 189.3 0.2 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDN05616.1 - 1.6e-31 108.8 1.4 2.1e-31 108.4 0.3 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDN05616.1 - 1.4e-15 57.6 2.8 2.3e-15 56.9 0.2 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN05616.1 - 1e-08 34.8 1.1 1.1e-06 28.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDN05616.1 - 0.00085 18.6 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EDN05616.1 - 0.017 14.5 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EDN05616.1 - 0.036 13.9 0.3 0.036 13.9 0.3 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EDN05616.1 - 0.078 12.0 2.6 5.2 6.0 0.6 3.0 3 0 0 3 3 3 0 FAD binding domain HI0933_like PF03486.14 EDN05616.1 - 0.15 10.7 1.3 2.8 6.5 0.2 2.5 2 1 1 3 3 3 0 HI0933-like protein GIDA PF01134.22 EDN05616.1 - 0.36 9.9 2.1 0.95 8.5 0.4 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A Pkinase PF00069.25 EDN05617.1 - 1.6e-53 181.8 0.0 4.7e-51 173.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05617.1 - 4.1e-32 111.5 0.0 3.1e-31 108.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN05617.1 - 0.0015 18.0 0.0 0.0022 17.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EDN05617.1 - 0.0018 17.4 0.1 0.0029 16.7 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EDN05617.1 - 0.0061 15.4 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EDN05617.1 - 0.14 11.1 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain MFS_1 PF07690.16 EDN05619.1 - 2.2e-17 63.0 58.4 3e-16 59.3 56.7 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SIT PF15330.6 EDN05619.1 - 0.56 10.7 0.0 0.56 10.7 0.0 2.9 4 0 0 4 4 4 0 SHP2-interacting transmembrane adaptor protein, SIT Bromodomain PF00439.25 EDN05621.1 - 3e-23 81.7 0.3 5.3e-23 80.9 0.3 1.4 1 0 0 1 1 1 1 Bromodomain Acetyltransf_10 PF13673.7 EDN05621.1 - 7.1e-07 29.2 0.5 2e-06 27.7 0.2 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN05621.1 - 1.1e-06 28.9 0.0 2.1e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN05621.1 - 0.0061 17.0 0.3 0.014 15.8 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Mem_trans PF03547.18 EDN05622.1 - 5.4e-49 166.6 1.1 1e-48 165.7 1.1 1.4 1 1 0 1 1 1 1 Membrane transport protein DUF2587 PF10759.9 EDN05623.1 - 0.021 14.3 0.1 0.021 14.3 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2587) Choline_kinase PF01633.20 EDN05624.1 - 3.3e-61 206.6 0.0 5.3e-61 205.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EDN05624.1 - 1.7e-20 72.5 0.0 3.1e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EDN05624.1 - 1.6e-08 34.8 0.5 8.7e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family FSIP1 PF15554.6 EDN05624.1 - 0.088 11.9 0.5 0.14 11.2 0.5 1.2 1 0 0 1 1 1 0 FSIP1 family Peptidase_C12 PF01088.21 EDN05625.1 - 1.7e-67 227.3 0.0 2.2e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EDN05625.1 - 2.8e-08 33.5 0.0 6.7e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases DDE_1 PF03184.19 EDN05626.1 - 1.6e-19 70.2 0.4 5.5e-19 68.5 0.0 2.1 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05626.1 - 8.6e-11 41.7 0.2 2.3e-09 37.2 0.0 2.9 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain PFL-like PF02901.15 EDN05626.1 - 0.0073 15.0 0.6 0.013 14.2 0.6 1.3 1 0 0 1 1 1 1 Pyruvate formate lyase-like DDE_3 PF13358.6 EDN05626.1 - 0.081 12.7 0.1 0.38 10.5 0.1 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease P3A PF08727.11 EDN05626.1 - 0.18 11.2 0.0 14 5.2 0.0 2.5 2 0 0 2 2 2 0 Poliovirus 3A protein like Zn_clus PF00172.18 EDN05627.1 - 2.1e-07 30.9 16.5 4.6e-07 29.9 16.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_15 PF13429.6 EDN05627.1 - 0.055 12.7 0.1 0.08 12.1 0.1 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat HEAT PF02985.22 EDN05628.1 - 3.3e-28 95.3 12.5 4.6e-05 23.3 0.0 10.9 12 0 0 12 12 11 5 HEAT repeat HEAT_EZ PF13513.6 EDN05628.1 - 3.3e-27 94.5 13.6 9.7e-17 61.1 0.0 10.4 10 1 3 13 13 13 2 HEAT-like repeat HEAT_2 PF13646.6 EDN05628.1 - 3.1e-19 69.2 0.2 8.6e-06 26.1 0.0 8.2 7 1 2 9 9 9 4 HEAT repeats Cnd1 PF12717.7 EDN05628.1 - 3.2e-14 53.3 0.0 3.4e-05 23.9 0.0 5.0 4 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDN05628.1 - 1.6e-10 41.5 0.0 0.12 13.0 0.0 6.6 4 2 4 8 8 8 3 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EDN05628.1 - 2.7e-10 40.0 0.3 0.029 13.5 0.0 4.6 4 1 0 4 4 4 3 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 EDN05628.1 - 2.3e-08 33.1 1.4 0.0044 15.6 0.4 4.5 2 2 1 3 3 3 3 Adaptin N terminal region Xpo1 PF08389.12 EDN05628.1 - 8e-06 26.0 0.0 0.0014 18.7 0.0 3.9 3 1 0 3 3 3 1 Exportin 1-like protein CLASP_N PF12348.8 EDN05628.1 - 2.2e-05 24.1 0.2 5.7 6.4 0.0 6.3 5 3 1 6 6 6 1 CLASP N terminal IBN_N PF03810.19 EDN05628.1 - 9.1e-05 22.3 0.1 0.0037 17.1 0.0 3.8 2 1 0 2 2 2 1 Importin-beta N-terminal domain Arm PF00514.23 EDN05628.1 - 0.00023 21.1 3.9 0.46 10.6 0.0 5.5 7 0 0 7 7 5 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EDN05628.1 - 0.00033 20.8 0.0 1.5 9.0 0.0 4.3 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 EDN05628.1 - 0.00091 19.7 0.3 0.63 10.9 0.0 4.2 3 0 0 3 3 2 1 PBS lyase HEAT-like repeat DUF3437 PF11919.8 EDN05628.1 - 0.016 15.1 0.0 0.17 11.8 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) RIX1 PF08167.12 EDN05628.1 - 0.032 14.0 0.1 25 4.5 0.0 4.2 4 1 0 4 4 4 0 rRNA processing/ribosome biogenesis UPF0253 PF06786.12 EDN05628.1 - 0.069 13.4 0.0 0.31 11.4 0.0 2.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) TIP120 PF08623.10 EDN05628.1 - 0.14 11.9 0.0 12 5.6 0.0 3.7 4 1 0 4 4 4 0 TATA-binding protein interacting (TIP20) Syja_N PF02383.18 EDN05630.1 - 9.3e-94 314.3 0.0 1.5e-93 313.6 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Lipase_GDSL PF00657.22 EDN05630.1 - 0.018 15.0 0.0 0.065 13.2 0.0 2.1 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase DUF2564 PF10819.8 EDN05630.1 - 0.46 10.9 3.3 1.3 9.4 2.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) Mg_trans_NIPA PF05653.14 EDN05631.1 - 3.3e-97 325.1 21.6 1.6e-50 171.9 2.1 2.0 1 1 1 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EDN05631.1 - 0.00011 22.4 7.9 0.00011 22.4 7.9 3.5 3 1 0 3 3 3 3 EamA-like transporter family Chromo PF00385.24 EDN05633.1 - 1.1e-05 25.2 0.2 2.3e-05 24.2 0.2 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain WD40 PF00400.32 EDN05634.1 - 2.2e-18 66.3 0.1 1.3e-10 41.7 0.1 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat NACHT PF05729.12 EDN05634.1 - 5e-10 39.5 0.2 2.7e-09 37.2 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EDN05634.1 - 3.8e-08 33.9 0.0 1.5e-07 32.0 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain ANAPC4_WD40 PF12894.7 EDN05634.1 - 0.00031 21.0 0.0 0.0037 17.5 0.0 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain APS_kinase PF01583.20 EDN05634.1 - 0.0007 19.5 0.1 0.0014 18.5 0.1 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase NB-ARC PF00931.22 EDN05634.1 - 0.0041 16.4 0.6 0.011 14.9 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 EDN05634.1 - 0.0046 17.1 0.1 0.046 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN05634.1 - 0.01 16.1 0.1 0.1 12.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain PHM7_cyt PF14703.6 EDN05634.1 - 0.014 15.7 0.1 0.031 14.5 0.1 1.5 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Cytidylate_kin PF02224.18 EDN05634.1 - 0.015 15.1 1.5 1.4 8.6 0.0 3.0 3 0 0 3 3 3 0 Cytidylate kinase Cytochrom_D1 PF02239.16 EDN05634.1 - 0.016 13.7 0.0 0.029 12.9 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain AAA PF00004.29 EDN05634.1 - 0.016 15.6 0.1 0.069 13.6 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RHD3 PF05879.12 EDN05634.1 - 0.034 12.3 0.3 0.062 11.4 0.0 1.5 2 0 0 2 2 2 0 Root hair defective 3 GTP-binding protein (RHD3) AAA_30 PF13604.6 EDN05634.1 - 0.043 13.5 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDN05634.1 - 0.045 13.7 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EDN05634.1 - 0.052 14.1 0.0 0.22 12.0 0.0 2.1 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN05634.1 - 0.059 13.8 0.1 0.4 11.1 0.0 2.4 2 0 0 2 2 2 0 RNA helicase WD40_like PF17005.5 EDN05634.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain MukF_M PF17192.4 EDN05635.1 - 0.042 13.6 0.5 0.26 11.0 0.1 1.9 1 1 1 2 2 2 0 MukF middle domain TTc_toxin_rep PF18807.1 EDN05635.1 - 0.17 11.7 0.0 6 6.8 0.0 2.3 2 0 0 2 2 2 0 Tripartite Tc toxins repeat TPR_10 PF13374.6 EDN05636.1 - 2e-68 224.6 6.7 2.4e-12 46.3 0.0 7.8 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 EDN05636.1 - 4.7e-53 177.4 3.2 8.3e-17 61.3 0.0 5.8 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 EDN05636.1 - 1.4e-19 68.6 3.9 0.0013 18.6 0.0 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 EDN05636.1 - 1.4e-13 50.6 0.1 4.5e-13 49.0 0.1 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily TPR_MalT PF17874.1 EDN05636.1 - 2.3e-11 43.7 8.2 1.1e-09 38.2 4.6 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_1 PF00515.28 EDN05636.1 - 3.4e-11 42.5 3.8 0.91 9.5 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat NB-ARC PF00931.22 EDN05636.1 - 7.2e-10 38.5 0.8 2.6e-09 36.7 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain TPR_19 PF14559.6 EDN05636.1 - 4.9e-09 36.6 2.1 1 9.9 0.1 5.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDN05636.1 - 9.7e-09 34.7 6.1 3 8.2 0.2 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 EDN05636.1 - 1.6e-07 31.2 0.1 2.5 9.0 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDN05636.1 - 5.8e-07 30.1 0.0 4.4 8.0 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN05636.1 - 4.9e-06 26.3 9.6 0.16 12.3 0.0 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat NACHT PF05729.12 EDN05636.1 - 4.7e-05 23.4 0.0 9.9e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EDN05636.1 - 0.00015 22.0 0.0 0.00061 20.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain TPR_17 PF13431.6 EDN05636.1 - 0.00016 21.8 4.2 1.6 9.3 0.0 5.0 5 0 0 5 5 4 1 Tetratricopeptide repeat AAA_16 PF13191.6 EDN05636.1 - 0.00045 20.6 0.0 0.0018 18.7 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain TPR_14 PF13428.6 EDN05636.1 - 0.0039 17.9 6.6 15 6.7 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat ParA PF10609.9 EDN05636.1 - 0.024 14.1 0.0 0.055 12.9 0.0 1.6 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase N1221 PF07923.13 EDN05636.1 - 0.028 13.6 1.1 3 7.0 0.2 2.5 1 1 1 2 2 2 0 N1221-like protein ATP-synt_Z PF16594.5 EDN05636.1 - 0.036 13.5 0.1 0.075 12.5 0.1 1.5 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated AAA_18 PF13238.6 EDN05636.1 - 0.049 14.2 0.0 0.16 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDN05636.1 - 0.072 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2508 PF10704.9 EDN05636.1 - 0.61 10.3 4.2 11 6.2 0.1 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF2508) Pkinase_fungal PF17667.1 EDN05637.1 - 2.1e-145 484.6 0.0 2.6e-145 484.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN05637.1 - 1.8e-07 30.8 0.0 3.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05637.1 - 0.0068 15.7 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN05637.1 - 0.034 14.1 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDN05637.1 - 0.13 11.9 0.0 0.68 9.5 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Zn_clus PF00172.18 EDN05639.1 - 1.9e-07 31.0 8.5 1.9e-07 31.0 8.5 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rnf-Nqr PF02508.14 EDN05639.1 - 0.15 12.1 4.2 0.54 10.2 4.0 1.9 1 1 1 2 2 2 0 Rnf-Nqr subunit, membrane protein GvpG PF05120.12 EDN05640.1 - 0.042 13.9 1.8 0.12 12.4 1.8 1.8 1 0 0 1 1 1 0 Gas vesicle protein G HSCB_C PF07743.13 EDN05640.1 - 0.051 14.1 8.1 3.6 8.1 0.5 3.8 4 0 0 4 4 4 0 HSCB C-terminal oligomerisation domain CorA PF01544.18 EDN05640.1 - 0.17 11.2 2.0 0.31 10.3 0.5 1.9 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Mis14 PF08641.12 EDN05640.1 - 0.56 10.5 5.0 5.9 7.2 3.6 3.0 2 2 0 2 2 2 0 Kinetochore protein Mis14 like CP2 PF04516.15 EDN05641.1 - 6.1e-74 248.2 0.0 3.9e-72 242.3 0.0 2.2 2 0 0 2 2 2 2 CP2 transcription factor bZIP_2 PF07716.15 EDN05641.1 - 0.0078 16.3 4.8 0.19 11.8 0.9 2.3 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EDN05641.1 - 0.28 11.3 8.1 0.48 10.6 4.8 2.2 2 0 0 2 2 2 0 bZIP transcription factor zf-C3HC4_3 PF13920.6 EDN05644.1 - 2.4e-07 30.5 10.0 3.6e-07 29.9 10.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN05644.1 - 2.7e-07 30.3 5.8 4.8e-07 29.5 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDN05644.1 - 3.8e-07 30.0 5.5 6.4e-07 29.2 5.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDN05644.1 - 4.2e-06 26.5 7.0 7.7e-06 25.6 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN05644.1 - 7.2e-05 23.0 11.9 0.00011 22.4 11.9 1.3 1 0 0 1 1 1 1 Ring finger domain MPS2 PF17060.5 EDN05644.1 - 8.4e-05 22.0 1.4 0.00011 21.6 1.4 1.1 1 0 0 1 1 1 1 Monopolar spindle protein 2 zf-RING_UBOX PF13445.6 EDN05644.1 - 0.00046 20.2 5.7 0.0011 18.9 5.7 1.7 1 1 0 1 1 1 1 RING-type zinc-finger Rox3 PF08633.10 EDN05644.1 - 0.002 18.5 1.2 0.0029 17.9 0.1 1.7 2 0 0 2 2 2 1 Rox3 mediator complex subunit Lebercilin PF15619.6 EDN05644.1 - 0.0026 17.4 6.3 0.0042 16.8 6.3 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease FPP PF05911.11 EDN05644.1 - 0.003 15.8 2.7 0.0032 15.8 2.7 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Prok-RING_4 PF14447.6 EDN05644.1 - 0.0043 16.9 10.1 0.0089 15.9 10.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 HAP1_N PF04849.13 EDN05644.1 - 0.0053 16.0 3.3 0.0053 16.0 3.3 1.6 1 1 1 2 2 2 1 HAP1 N-terminal conserved region Sigma70_ner PF04546.13 EDN05644.1 - 0.021 14.7 2.5 0.027 14.4 2.5 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region zf-RING_4 PF14570.6 EDN05644.1 - 0.046 13.5 3.2 0.046 13.5 3.2 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Cauli_DNA-bind PF03310.13 EDN05644.1 - 0.057 13.5 0.5 0.35 10.9 0.0 2.4 2 1 1 3 3 3 0 Caulimovirus DNA-binding protein DUF737 PF05300.11 EDN05644.1 - 0.06 13.7 3.0 0.073 13.4 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF4461 PF14688.6 EDN05644.1 - 0.074 12.8 1.6 0.11 12.2 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4461) zf-RING_6 PF14835.6 EDN05644.1 - 0.076 12.9 5.9 0.13 12.2 5.9 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Jnk-SapK_ap_N PF09744.9 EDN05644.1 - 0.091 13.0 7.1 0.13 12.4 7.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.10 EDN05644.1 - 0.34 11.1 4.5 1.4 9.1 4.6 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family bZIP_1 PF00170.21 EDN05644.1 - 0.84 9.8 6.8 0.44 10.7 3.8 2.0 2 0 0 2 2 2 0 bZIP transcription factor Macoilin PF09726.9 EDN05644.1 - 1.4 7.3 8.3 0.86 8.1 6.2 1.5 1 1 1 2 2 2 0 Macoilin family zf-C3HC4_4 PF15227.6 EDN05644.1 - 7.6 6.8 10.8 15 5.9 9.3 2.3 1 1 2 3 3 3 0 zinc finger of C3HC4-type, RING HAUS-augmin3 PF14932.6 EDN05645.1 - 5.7e-05 22.8 1.1 7.7e-05 22.4 1.1 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 zf-C3HC4_3 PF13920.6 EDN05645.1 - 0.00013 21.7 10.2 0.00019 21.2 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UPF0242 PF06785.11 EDN05645.1 - 0.00014 22.0 1.1 0.00021 21.5 1.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DegS PF05384.11 EDN05645.1 - 0.00026 20.5 2.3 0.00039 20.0 2.3 1.2 1 0 0 1 1 1 1 Sensor protein DegS zf-C3HC4 PF00097.25 EDN05645.1 - 0.00056 19.7 8.2 0.0011 18.8 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Lebercilin PF15619.6 EDN05645.1 - 0.0015 18.2 2.7 0.012 15.3 2.6 1.9 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF4200 PF13863.6 EDN05645.1 - 0.0027 18.1 5.6 0.0044 17.4 5.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Troponin PF00992.20 EDN05645.1 - 0.0032 17.8 4.8 0.0051 17.1 4.8 1.3 1 0 0 1 1 1 1 Troponin Fib_alpha PF08702.10 EDN05645.1 - 0.011 16.0 0.4 0.015 15.5 0.4 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-C3HC4_2 PF13923.6 EDN05645.1 - 0.011 15.5 8.2 0.022 14.6 8.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DivIC PF04977.15 EDN05645.1 - 0.012 15.4 1.2 0.021 14.6 1.2 1.4 1 0 0 1 1 1 0 Septum formation initiator zf-RING_5 PF14634.6 EDN05645.1 - 0.014 15.4 8.2 0.023 14.6 8.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DUF4407 PF14362.6 EDN05645.1 - 0.014 14.8 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Interferon PF00143.19 EDN05645.1 - 0.014 15.6 0.0 0.018 15.2 0.0 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain Fez1 PF06818.15 EDN05645.1 - 0.016 15.6 2.4 0.024 15.1 2.4 1.2 1 0 0 1 1 1 0 Fez1 Macoilin PF09726.9 EDN05645.1 - 0.019 13.5 2.8 0.024 13.2 2.8 1.1 1 0 0 1 1 1 0 Macoilin family ADIP PF11559.8 EDN05645.1 - 0.027 14.6 3.0 0.049 13.7 3.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 EDN05645.1 - 0.028 13.8 2.1 0.039 13.3 2.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EDN05645.1 - 0.037 14.4 1.5 1.9 8.9 0.4 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4164 PF13747.6 EDN05645.1 - 0.068 13.5 5.0 0.12 12.6 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) CENP-Q PF13094.6 EDN05645.1 - 0.081 13.1 2.2 0.11 12.6 2.2 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Exonuc_VII_L PF02601.15 EDN05645.1 - 0.1 12.1 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Trimer_CC PF08954.11 EDN05645.1 - 0.11 12.1 5.7 0.24 11.0 5.7 1.6 1 0 0 1 1 1 0 Trimerisation motif DUF848 PF05852.11 EDN05645.1 - 0.17 12.0 3.2 0.28 11.3 3.2 1.4 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1192 PF06698.11 EDN05645.1 - 0.18 11.9 2.9 0.37 10.9 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) BLOC1_2 PF10046.9 EDN05645.1 - 0.19 12.0 1.5 0.28 11.5 1.5 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2730 PF10805.8 EDN05645.1 - 0.21 11.7 0.7 0.4 10.8 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) TMF_TATA_bd PF12325.8 EDN05645.1 - 0.31 11.3 5.0 0.81 9.9 5.0 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Metal_resist PF13801.6 EDN05645.1 - 3.3 7.9 7.7 0.16 12.2 2.3 1.5 2 0 0 2 2 1 0 Heavy-metal resistance zf-RING_2 PF13639.6 EDN05645.1 - 3.8 7.9 13.1 6.5 7.2 13.1 1.4 1 0 0 1 1 1 0 Ring finger domain bZIP_1 PF00170.21 EDN05645.1 - 7.2 6.8 11.0 0.16 12.1 3.7 2.1 2 1 0 2 2 1 0 bZIP transcription factor DUF3435 PF11917.8 EDN05646.1 - 4.8e-36 124.6 0.0 2.7e-35 122.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) Nexin_C PF08628.12 EDN05647.1 - 0.0037 17.8 0.6 0.0044 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal Adap_comp_sub PF00928.21 EDN05648.1 - 2.7e-24 86.0 0.1 3.9e-24 85.5 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDN05648.1 - 6.3e-08 32.7 0.2 1.1e-07 31.9 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 EDN05648.1 - 0.0016 18.9 0.3 0.0029 18.0 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) DUF2420 PF10336.9 EDN05649.1 - 1.2e-17 63.9 0.0 2.2e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) PRMT5 PF05185.16 EDN05650.1 - 0.055 13.3 0.0 0.058 13.2 0.0 1.1 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase OMPdecase PF00215.24 EDN05652.1 - 3.2e-07 30.2 0.0 1.7e-05 24.5 0.0 2.4 2 1 0 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family Cyt-b5 PF00173.28 EDN05653.1 - 1.4e-18 66.8 0.2 1.4e-18 66.8 0.2 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EDN05653.1 - 4.3e-13 49.7 13.8 4.3e-13 49.7 13.8 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily RRM_1 PF00076.22 EDN05654.1 - 3.7e-40 135.6 0.4 9.6e-19 67.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EDN05654.1 - 2e-24 86.5 0.0 5.9e-24 85.0 0.0 1.9 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EDN05654.1 - 0.00069 19.4 0.0 0.44 10.4 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EDN05654.1 - 0.083 12.9 0.0 0.38 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif PHM7_cyt PF14703.6 EDN05654.1 - 0.093 13.0 0.0 4.8 7.4 0.0 2.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EDN05654.1 - 0.18 12.0 0.0 3.5 7.8 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif Atg14 PF10186.9 EDN05655.1 - 0.00049 19.3 1.0 0.00072 18.7 1.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 EDN05655.1 - 0.0027 16.6 0.8 0.0042 16.0 0.8 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Es2 PF09751.9 EDN05655.1 - 0.0039 17.0 3.1 0.0055 16.5 3.1 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 Tropomyosin PF00261.20 EDN05655.1 - 0.0071 15.8 3.5 0.01 15.3 3.5 1.1 1 0 0 1 1 1 1 Tropomyosin DUF16 PF01519.16 EDN05655.1 - 0.0095 16.4 0.3 0.016 15.7 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF16 SlyX PF04102.12 EDN05655.1 - 0.017 15.7 3.9 0.44 11.2 0.1 2.6 1 1 1 2 2 2 0 SlyX SPATA24 PF15175.6 EDN05655.1 - 0.038 13.9 1.0 0.067 13.1 1.0 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 MCPsignal PF00015.21 EDN05655.1 - 0.078 12.8 1.4 0.15 11.9 1.4 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SYCE1 PF15233.6 EDN05655.1 - 0.087 12.9 2.2 0.14 12.2 2.2 1.2 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 EzrA PF06160.12 EDN05655.1 - 0.09 10.9 3.5 0.13 10.5 3.5 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA SKA1 PF07160.12 EDN05655.1 - 0.096 12.5 1.8 0.24 11.2 1.5 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF3584 PF12128.8 EDN05655.1 - 0.17 9.4 3.7 0.22 9.0 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4200 PF13863.6 EDN05655.1 - 0.24 11.8 3.8 0.38 11.2 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) zf-CpG_bind_C PF12269.8 EDN05655.1 - 0.3 10.8 1.2 1.2 8.9 0.9 1.8 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain FAM76 PF16046.5 EDN05655.1 - 0.32 10.3 4.6 0.47 9.8 4.6 1.2 1 0 0 1 1 1 0 FAM76 protein TMF_DNA_bd PF12329.8 EDN05655.1 - 0.63 10.1 5.9 2.6 8.1 6.0 1.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3552 PF12072.8 EDN05655.1 - 0.73 9.2 7.1 0.23 10.8 3.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DUF745 PF05335.13 EDN05655.1 - 4.7 6.9 9.2 0.23 11.2 2.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF745) PP2C PF00481.21 EDN05656.1 - 3.4e-33 115.4 0.0 1.7e-27 96.7 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EDN05656.1 - 0.0019 17.8 0.0 0.0051 16.5 0.0 1.7 1 0 0 1 1 1 1 Protein phosphatase 2C Iso_dh PF00180.20 EDN05657.1 - 5e-127 423.8 0.0 5.7e-127 423.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ANAPC10 PF03256.16 EDN05658.1 - 3.6e-30 105.0 0.0 9.6e-30 103.6 0.0 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) CENP-B_dimeris PF09026.10 EDN05658.1 - 0.29 11.6 20.8 0.071 13.5 6.8 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDP-OH_P_transf PF01066.21 EDN05659.1 - 1.9e-13 51.0 0.7 1.9e-13 51.0 0.7 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase YhzD PF14120.6 EDN05660.1 - 0.13 12.4 0.2 0.3 11.2 0.2 1.6 1 0 0 1 1 1 0 YhzD-like protein E1-E2_ATPase PF00122.20 EDN05661.1 - 1.4e-35 122.5 20.1 4.3e-30 104.6 0.5 3.3 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDN05661.1 - 4.7e-26 91.6 9.9 4.7e-26 91.6 9.9 2.7 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EDN05661.1 - 8.1e-19 67.5 0.0 1.6e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDN05661.1 - 5.5e-18 66.0 0.0 1.9e-16 61.0 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN05661.1 - 4.3e-09 35.9 0.0 1e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDN05661.1 - 0.00025 20.9 0.2 0.00093 19.0 0.3 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Wzy_C PF04932.15 EDN05661.1 - 2.7 7.6 6.0 1.6 8.4 0.4 2.8 3 0 0 3 3 3 0 O-Antigen ligase Pkinase PF00069.25 EDN05662.1 - 7.7e-17 61.5 0.0 9.5e-17 61.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05662.1 - 0.00013 21.3 0.0 0.00015 21.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN05662.1 - 0.0026 17.7 0.1 0.0088 16.0 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN05662.1 - 0.0071 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDN05662.1 - 0.023 14.3 0.0 0.027 14.1 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EDN05662.1 - 0.027 13.8 0.0 0.033 13.5 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EDN05662.1 - 0.038 12.8 0.0 0.061 12.1 0.0 1.3 2 0 0 2 2 2 0 Fungal protein kinase PS_Dcarbxylase PF02666.15 EDN05663.1 - 2.9e-73 245.7 0.0 1.1e-72 243.8 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase ubiquitin PF00240.23 EDN05664.1 - 0.0014 18.3 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Terpene_synth_C PF03936.16 EDN05665.1 - 0.00011 21.7 0.2 0.00033 20.1 0.0 1.8 1 1 1 2 2 2 1 Terpene synthase family, metal binding domain TRI5 PF06330.11 EDN05665.1 - 0.048 12.5 0.0 0.087 11.7 0.0 1.3 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) Tobravirus_2B PF05271.11 EDN05665.1 - 0.065 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Tobravirus 2B protein His_Phos_1 PF00300.22 EDN05668.1 - 6.4e-11 42.3 0.0 4.8e-05 23.1 0.0 2.9 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Ribosomal_S8 PF00410.19 EDN05669.1 - 5.7e-22 78.0 0.1 8.5e-22 77.5 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Ank PF00023.30 EDN05670.1 - 2.1e-42 141.8 8.2 1.1e-05 25.7 0.0 9.5 10 0 0 10 10 10 6 Ankyrin repeat Ank_2 PF12796.7 EDN05670.1 - 7.8e-42 141.8 1.3 2.5e-09 37.6 0.0 5.4 4 1 0 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN05670.1 - 1.1e-37 127.9 3.7 8.4e-07 29.4 0.1 8.5 4 3 5 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN05670.1 - 6.6e-35 118.7 4.0 7e-09 35.8 0.0 5.3 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN05670.1 - 1.3e-30 102.0 9.3 1e-05 25.5 0.0 11.0 11 1 0 11 11 11 6 Ankyrin repeat F-box-like PF12937.7 EDN05670.1 - 0.00054 19.8 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like HEAT PF02985.22 EDN05671.1 - 1.1e-19 68.8 4.8 0.00011 22.1 0.0 9.2 8 0 0 8 8 8 3 HEAT repeat HEAT_EZ PF13513.6 EDN05671.1 - 1.4e-12 47.8 10.5 5.3e-08 33.2 0.0 7.1 8 1 0 8 8 7 1 HEAT-like repeat IBN_N PF03810.19 EDN05671.1 - 7.8e-08 32.1 3.4 1.3e-05 25.0 0.1 3.7 4 0 0 4 4 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EDN05671.1 - 8.8e-08 32.4 10.1 0.0011 19.3 0.2 6.4 2 2 5 7 7 7 4 HEAT repeats Arm PF00514.23 EDN05671.1 - 8.4e-06 25.6 3.7 3.1 8.0 0.0 6.1 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat Ecm29 PF13001.7 EDN05671.1 - 0.00025 19.9 0.8 0.41 9.3 0.0 3.6 2 1 0 3 3 3 1 Proteasome stabiliser DUF3385 PF11865.8 EDN05671.1 - 0.00026 20.9 1.2 1.9 8.4 0.0 4.0 2 2 1 3 3 3 2 Domain of unknown function (DUF3385) HEAT_PBS PF03130.16 EDN05671.1 - 0.00029 21.2 0.1 3.2 8.7 0.0 5.1 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat CLASP_N PF12348.8 EDN05671.1 - 0.00043 19.9 1.5 1.5 8.3 0.0 4.5 3 2 1 5 5 5 1 CLASP N terminal Tti2 PF10521.9 EDN05671.1 - 0.005 16.4 0.8 0.3 10.6 0.8 2.8 2 1 0 2 2 2 1 Tti2 family Dopey_N PF04118.14 EDN05671.1 - 0.0084 15.3 0.1 0.094 11.8 0.0 2.5 2 1 1 3 3 3 1 Dopey, N-terminal Sec7_N PF12783.7 EDN05671.1 - 0.13 12.1 0.2 5.2 6.9 0.2 3.3 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal NUC173 PF08161.12 EDN05671.1 - 0.13 11.9 1.7 6.8 6.3 0.0 3.7 4 0 0 4 4 4 0 NUC173 domain RGS PF00615.19 EDN05671.1 - 0.14 12.5 0.1 0.46 10.8 0.1 1.9 1 0 0 1 1 1 0 Regulator of G protein signaling domain ANAPC4 PF12896.7 EDN05672.1 - 1.3e-66 224.1 0.3 2.1e-66 223.4 0.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EDN05672.1 - 1.7e-23 82.7 0.0 8.6e-22 77.2 0.0 3.0 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain IL1 PF00340.19 EDN05672.1 - 0.078 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Interleukin-1 / 18 Pkinase_fungal PF17667.1 EDN05674.1 - 3e-141 470.9 0.0 3.8e-141 470.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN05674.1 - 3.8e-07 29.8 0.0 6.1e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN05674.1 - 0.01 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EDN05674.1 - 0.019 14.3 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN05678.1 - 9.1e-127 423.2 0.0 1.1e-126 422.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase DCD PF06559.11 EDN05678.1 - 0.041 12.7 0.0 0.063 12.1 0.0 1.2 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Stork_head PF10264.9 EDN05678.1 - 0.059 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain APH PF01636.23 EDN05680.1 - 1.4e-15 57.9 0.1 2.3e-15 57.2 0.1 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN05680.1 - 0.0002 21.0 0.0 0.00034 20.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DEAD PF00270.29 EDN05681.1 - 2.2e-09 37.3 0.0 4.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN05681.1 - 5.5e-05 23.2 0.0 0.00014 21.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN05681.1 - 0.03 14.6 0.2 0.13 12.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain Pkinase_fungal PF17667.1 EDN05682.1 - 3.6e-139 464.1 0.0 4.5e-139 463.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN05682.1 - 3.3e-07 30.0 0.0 5.4e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05682.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN05682.1 - 0.049 13.5 0.1 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family DDE_1 PF03184.19 EDN05684.1 - 2.4e-14 53.3 0.0 1.1e-13 51.2 0.0 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN05684.1 - 0.026 14.3 0.1 0.12 12.2 0.1 2.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Macoilin PF09726.9 EDN05684.1 - 8.4 4.8 14.3 12 4.3 14.3 1.2 1 0 0 1 1 1 0 Macoilin family DUF3435 PF11917.8 EDN05685.1 - 2.5e-11 43.2 0.0 2.5e-11 43.2 0.0 2.5 4 0 0 4 4 4 1 Protein of unknown function (DUF3435) VWA PF00092.28 EDN05686.1 - 0.0003 21.1 0.0 0.0014 18.9 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain F-box_5 PF18511.1 EDN05686.1 - 0.044 13.4 0.1 0.54 9.9 0.0 2.3 2 0 0 2 2 2 0 F-box VWA_2 PF13519.6 EDN05686.1 - 0.15 12.7 0.0 0.39 11.4 0.0 1.8 2 0 0 2 2 2 0 von Willebrand factor type A domain LRR_RI_capping PF18779.1 EDN05686.1 - 2.7 7.7 3.9 3 7.6 0.2 2.2 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat Acetyltransf_7 PF13508.7 EDN05688.1 - 1.1e-09 38.6 0.0 1.7e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDN05688.1 - 3.9e-09 36.5 0.0 1.1e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN05688.1 - 7e-09 35.9 0.0 1.3e-08 35.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 EDN05688.1 - 0.00029 20.9 0.0 0.00054 20.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EDN05688.1 - 0.085 12.9 0.0 3.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain BTB PF00651.31 EDN05689.1 - 2.4e-06 27.7 0.0 4.9e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain CDC45 PF02724.14 EDN05690.1 - 3.9e-214 712.6 7.2 7.2e-212 705.1 7.2 3.0 1 1 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EDN05690.1 - 0.016 14.5 27.6 0.11 11.9 13.0 2.3 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.12 EDN05690.1 - 0.035 13.8 31.2 0.44 10.2 19.9 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 EDN05690.1 - 0.049 11.8 21.2 0.0052 15.1 9.4 2.1 2 0 0 2 2 2 0 Nop14-like family CNDH2_C PF16858.5 EDN05690.1 - 2.1 8.1 12.6 0.089 12.6 5.8 1.9 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF572 PF04502.13 EDN05690.1 - 2.5 7.6 16.5 0.64 9.6 8.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) SPX PF03105.19 EDN05690.1 - 3.8 7.3 24.7 1.2 9.0 9.0 2.4 2 0 0 2 2 2 0 SPX domain FAM60A PF15396.6 EDN05690.1 - 5.2 7.0 12.2 0.17 11.8 3.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Nop25 PF09805.9 EDN05690.1 - 7.8 7.0 22.9 3 8.3 15.8 2.4 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) CSRNP_N PF16019.5 EDN05690.1 - 7.9 6.3 8.3 18 5.1 8.3 1.6 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Peptidase_C13 PF01650.18 EDN05691.1 - 3.8e-40 138.0 0.0 4.7e-40 137.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family F-box-like PF12937.7 EDN05692.1 - 3.7e-11 42.7 0.1 8.9e-11 41.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN05692.1 - 1.1e-06 28.3 0.1 3.6e-06 26.7 0.1 1.9 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EDN05692.1 - 0.041 13.8 0.1 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 F-box DUF2511 PF10709.9 EDN05692.1 - 0.11 12.8 0.0 0.46 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2511) Ccdc124 PF06244.12 EDN05693.1 - 1.2e-27 97.0 20.0 1.2e-27 97.0 20.0 2.3 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 Alpha-amylase PF00128.24 EDN05694.1 - 1.9e-11 44.1 0.7 4.8e-11 42.8 0.7 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EDN05694.1 - 6.5e-05 21.3 0.1 0.035 12.3 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolase family 70 Mito_carr PF00153.27 EDN05695.1 - 5.8e-45 151.2 6.3 9.6e-17 60.7 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Flavin_Reduct PF01613.18 EDN05698.1 - 9.3e-17 61.5 0.0 1.8e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Flavin reductase like domain PAP_central PF04928.17 EDN05699.1 - 2.2e-108 361.0 0.0 2.7e-108 360.6 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EDN05699.1 - 2.8e-56 189.8 0.0 4.3e-56 189.2 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EDN05699.1 - 4.6e-11 42.9 0.0 9.9e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EDN05699.1 - 0.086 12.6 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Amidase PF01425.21 EDN05700.1 - 3.4e-89 299.9 0.0 4.4e-89 299.5 0.0 1.1 1 0 0 1 1 1 1 Amidase Pyr_redox_2 PF07992.14 EDN05701.1 - 1.8e-36 125.9 0.0 5.2e-35 121.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN05701.1 - 2.8e-07 31.0 0.0 3.7e-06 27.4 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN05701.1 - 0.082 12.9 0.0 0.61 10.1 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trypan_glycop PF00913.19 EDN05702.1 - 2.6 7.2 9.7 0.51 9.5 4.1 2.0 2 0 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) HSP20 PF00011.21 EDN05703.1 - 7.6e-10 38.9 0.1 1.4e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EDN05703.1 - 0.0046 16.5 0.1 0.13 11.8 0.1 2.4 1 1 0 1 1 1 1 HSP20-like domain found in ArsA HflK_N PF12221.8 EDN05703.1 - 0.17 12.0 2.3 0.61 10.1 0.8 2.3 2 0 0 2 2 2 0 Bacterial membrane protein N terminal VDE PF07137.11 EDN05704.1 - 0.12 11.9 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 VDE lipocalin domain Pectate_lyase_3 PF12708.7 EDN05706.1 - 4.2e-103 343.8 14.1 5.3e-87 291.2 10.1 2.5 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EDN05706.1 - 1.6e-08 34.1 2.4 0.00036 20.1 0.2 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Aminotran_1_2 PF00155.21 EDN05707.1 - 1.7e-19 70.3 0.0 3.6e-16 59.3 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II MJ1316 PF04457.12 EDN05711.1 - 9.3e-21 74.4 0.2 2.1e-20 73.2 0.2 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain PAP_central PF04928.17 EDN05711.1 - 5.3e-17 61.6 0.0 8.4e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase central domain 2_5_RNA_ligase2 PF13563.6 EDN05711.1 - 1.5e-16 60.7 0.0 2.9e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Exo_endo_phos PF03372.23 EDN05711.1 - 1.3e-06 28.1 0.0 2.2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 EDN05711.1 - 0.00063 20.0 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cation_efflux PF01545.21 EDN05712.1 - 1.9e-14 53.9 7.7 2.3e-14 53.6 7.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EDN05712.1 - 2.6e-10 40.3 0.3 8e-10 38.7 0.3 1.8 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter MAGI_u5 PF16666.5 EDN05712.1 - 0.27 11.4 5.6 0.48 10.6 5.6 1.4 1 0 0 1 1 1 0 Unstructured region on MAGI ADH_zinc_N_2 PF13602.6 EDN05714.1 - 8.9e-24 85.0 0.0 3.3e-23 83.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDN05714.1 - 4.8e-15 55.7 0.7 1.6e-14 54.0 0.2 2.0 3 0 0 3 3 3 1 Zinc-binding dehydrogenase GAT PF03127.14 EDN05715.1 - 1.2e-14 54.3 0.0 2.4e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 GAT domain DprA_WH PF17782.1 EDN05715.1 - 0.08 13.1 1.0 0.3 11.2 1.0 2.0 1 0 0 1 1 1 0 DprA winged helix domain NAD_binding_6 PF08030.12 EDN05717.1 - 9.4e-14 51.8 0.1 7.5e-10 39.1 0.0 2.6 2 1 1 3 3 3 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDN05717.1 - 5.6e-13 49.1 5.3 1.3e-12 47.9 5.3 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDN05717.1 - 2.1e-09 37.4 0.2 3.5e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EDN05717.1 - 0.0049 17.5 0.0 0.056 14.1 0.0 2.7 3 1 0 3 3 3 1 Oxidoreductase NAD-binding domain adh_short_C2 PF13561.6 EDN05718.1 - 2e-47 161.7 0.0 2.4e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN05718.1 - 7.9e-39 133.1 0.0 1.5e-38 132.2 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDN05718.1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.6 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EDN05719.1 - 1.8e-21 76.8 0.0 5.4e-14 52.3 0.0 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN05719.1 - 1.9e-17 63.4 0.0 1.3e-16 60.6 0.0 2.1 1 1 1 2 2 2 1 short chain dehydrogenase Fungal_trans PF04082.18 EDN05719.1 - 1.5e-11 43.9 0.0 5.7e-11 41.9 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN05719.1 - 1.2e-05 25.3 8.1 2.1e-05 24.5 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KR PF08659.10 EDN05719.1 - 0.085 12.8 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 KR domain ADH_N PF08240.12 EDN05720.1 - 5.1e-26 90.7 0.1 2.1e-25 88.7 0.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN05720.1 - 6.4e-10 39.1 0.0 1.4e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDN05720.1 - 7.1e-08 32.2 0.1 0.00065 19.2 0.1 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 EDN05720.1 - 0.0066 16.7 0.0 0.029 14.6 0.0 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EDN05720.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RNA_Me_trans PF04252.13 EDN05721.1 - 0.061 12.9 0.0 0.066 12.8 0.0 1.1 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase DDE_3 PF13358.6 EDN05722.1 - 6.7e-08 32.4 0.8 1.1e-07 31.7 0.6 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease 2-Hacid_dh_C PF02826.19 EDN05723.1 - 8.5e-54 181.6 0.0 1.2e-53 181.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN05723.1 - 8e-21 74.1 0.0 1e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Ribosomal_L22 PF00237.19 EDN05724.1 - 1.4e-41 140.9 0.1 2.3e-41 140.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e LTD PF00932.19 EDN05724.1 - 0.067 13.6 0.0 0.098 13.0 0.0 1.4 1 0 0 1 1 1 0 Lamin Tail Domain Glyco_hydro_20 PF00728.22 EDN05725.1 - 1.5e-22 80.5 0.1 9.4e-20 71.3 0.1 2.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 EDN05725.1 - 3.1e-11 44.1 0.0 8.6e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF3841 PF12952.7 EDN05725.1 - 0.19 11.5 1.0 0.4 10.5 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3841) Epimerase PF01370.21 EDN05726.1 - 8e-10 38.6 0.0 5.2e-09 35.9 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EDN05726.1 - 4.3e-08 32.6 0.0 0.00029 20.1 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EDN05726.1 - 1.3e-07 30.9 0.0 2.2e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDN05726.1 - 2.5e-07 30.4 0.1 4.9e-06 26.2 0.0 2.5 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDN05726.1 - 6.7e-06 26.1 0.0 1.5e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDN05726.1 - 0.0037 16.8 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family UBA_4 PF14555.6 EDN05727.1 - 6.9e-12 45.0 0.1 1.5e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EDN05727.1 - 1.4e-09 38.0 0.0 3.5e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 UBX domain DUF1682 PF07946.14 EDN05727.1 - 0.00094 18.5 1.4 0.0013 18.0 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Asp-B-Hydro_N PF05279.11 EDN05727.1 - 0.0056 16.8 0.7 0.0098 16.0 0.7 1.3 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region Thioredoxin_7 PF13899.6 EDN05727.1 - 0.11 12.6 0.0 0.4 10.9 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like Presenilin PF01080.17 EDN05727.1 - 1.8 7.3 3.9 2.5 6.8 3.9 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 EDN05727.1 - 6.6 6.0 10.9 10 5.3 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pan3_PK PF18101.1 EDN05728.1 - 8e-64 213.7 0.2 1.2e-63 213.2 0.2 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EDN05728.1 - 1.7e-06 27.6 0.0 2.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05728.1 - 0.17 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase LSM PF01423.22 EDN05729.1 - 1.1e-19 69.8 0.4 1.5e-19 69.4 0.4 1.2 1 0 0 1 1 1 1 LSM domain DUF2722 PF10846.8 EDN05729.1 - 0.048 12.6 5.8 0.048 12.6 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FAM60A PF15396.6 EDN05729.1 - 0.052 13.6 0.1 0.071 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Suf PF05843.14 EDN05729.1 - 0.11 12.5 0.7 0.13 12.3 0.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med15 PF09606.10 EDN05729.1 - 0.2 10.3 15.7 0.2 10.3 15.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4175 PF13779.6 EDN05729.1 - 0.52 8.2 13.6 0.53 8.1 13.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) eIF-3_zeta PF05091.12 EDN05729.1 - 0.69 8.8 4.9 0.74 8.7 4.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 EDN05729.1 - 1 8.9 14.1 1.4 8.5 14.1 1.1 1 0 0 1 1 1 0 Spt20 family HemX PF04375.14 EDN05729.1 - 1.1 8.5 7.1 1.3 8.3 7.1 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase dsDNA_bind PF01984.20 EDN05729.1 - 2.4 8.5 15.7 3.8 7.8 15.7 1.3 1 0 0 1 1 1 0 Double-stranded DNA-binding domain SUIM_assoc PF16619.5 EDN05729.1 - 7.8 6.6 22.0 3.8 7.6 1.6 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA PF00004.29 EDN05730.1 - 3.2e-19 69.7 0.0 5.7e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN05730.1 - 0.00015 22.2 0.1 0.00043 20.7 0.1 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDN05730.1 - 0.00017 21.6 0.0 0.00041 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EDN05730.1 - 0.00088 19.8 0.1 0.023 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN05730.1 - 0.0012 19.1 1.2 0.027 14.8 0.0 2.8 2 1 1 3 3 3 1 AAA domain Zot PF05707.12 EDN05730.1 - 0.0061 16.2 0.1 0.064 12.9 0.0 2.1 1 1 0 2 2 2 1 Zonular occludens toxin (Zot) IstB_IS21 PF01695.17 EDN05730.1 - 0.0081 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 EDN05730.1 - 0.0081 16.4 0.0 0.074 13.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EDN05730.1 - 0.01 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EDN05730.1 - 0.032 14.4 0.0 0.14 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) T2SSE PF00437.20 EDN05730.1 - 0.059 12.4 0.0 0.091 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EDN05730.1 - 0.11 11.8 0.1 0.29 10.5 0.1 1.6 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EDN05730.1 - 0.11 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EDN05730.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDN05730.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDN05730.1 - 0.17 12.2 0.2 0.56 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zn_clus PF00172.18 EDN05731.1 - 0.11 12.7 10.5 0.29 11.3 10.5 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PADR1 PF08063.12 EDN05731.1 - 0.14 12.0 4.1 0.29 11.0 4.1 1.5 1 0 0 1 1 1 0 PADR1 (NUC008) domain DUF2065 PF09838.9 EDN05732.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) TMEM125 PF15109.6 EDN05732.1 - 0.25 11.7 0.5 0.53 10.6 0.2 1.6 2 0 0 2 2 2 0 TMEM125 protein family CASP_C PF08172.12 EDN05734.1 - 2.4e-92 308.8 2.8 2.4e-92 308.8 2.8 3.8 3 2 2 5 5 5 1 CASP C terminal DUF4763 PF15960.5 EDN05734.1 - 0.0048 16.2 4.3 0.0048 16.2 4.3 4.4 4 1 1 5 5 5 2 Domain of unknown function (DUF4763) NAD_binding_1 PF00175.21 EDN05734.1 - 0.096 13.3 1.5 3.2 8.5 0.0 3.4 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain PKcGMP_CC PF16808.5 EDN05734.1 - 2 8.3 7.6 0.47 10.4 0.5 3.5 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2990 PF11693.8 EDN05735.1 - 1.7e-08 34.5 1.4 2.9e-08 33.8 1.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2990) Mannosyl_trans3 PF11051.8 EDN05736.1 - 1.8e-52 178.4 0.0 5.2e-32 111.3 0.0 2.1 1 1 1 2 2 2 2 Mannosyltransferase putative Fibrillarin PF01269.17 EDN05737.1 - 3.2e-74 248.9 0.0 4.2e-74 248.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EDN05737.1 - 9.9e-05 22.1 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 EDN05737.1 - 0.012 15.2 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EDN05737.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Epimerase PF01370.21 EDN05738.1 - 0.00056 19.5 0.0 0.00083 18.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN05738.1 - 0.096 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Peptidase_M16 PF00675.20 EDN05739.1 - 3.2e-55 186.2 0.1 1.4e-54 184.1 0.4 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDN05739.1 - 2.2e-37 128.8 0.0 5.7e-36 124.2 0.0 2.4 3 0 0 3 3 3 1 Peptidase M16 inactive domain ADH_zinc_N PF00107.26 EDN05740.1 - 5.9e-20 71.6 0.0 8.2e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EDN05740.1 - 5.7e-18 64.8 0.0 1.3e-17 63.7 0.0 1.6 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EDN05740.1 - 3.8e-10 40.9 0.0 6.5e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CybS PF05328.12 EDN05741.1 - 1.2e-55 186.8 0.0 3.1e-55 185.5 0.0 1.6 2 0 0 2 2 2 1 CybS, succinate dehydrogenase cytochrome B small subunit Maf PF02545.14 EDN05742.1 - 6.5e-47 159.5 0.0 7.7e-47 159.2 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein HLH PF00010.26 EDN05743.1 - 3.9e-08 33.1 0.0 8.5e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PRCC PF10253.9 EDN05743.1 - 0.082 13.7 9.3 0.092 13.5 9.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Macoilin PF09726.9 EDN05743.1 - 1.6 7.2 7.0 2 6.9 7.0 1.0 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EDN05743.1 - 1.9 7.2 3.3 1.9 7.2 3.3 1.1 1 0 0 1 1 1 0 Presenilin Nucleo_P87 PF07267.11 EDN05743.1 - 3.3 6.4 6.2 3.7 6.3 6.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Hamartin PF04388.12 EDN05743.1 - 4.1 5.9 11.0 4.1 5.9 11.0 1.0 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 EDN05743.1 - 6.6 5.3 10.1 6.9 5.2 10.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GFA PF04828.14 EDN05744.1 - 0.045 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.6 EDN05744.1 - 0.57 10.1 2.3 4.2 7.4 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal zf-NADH-PPase PF09297.11 EDN05744.1 - 8.4 6.1 8.3 0.51 10.0 1.7 2.4 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain UBA_4 PF14555.6 EDN05746.1 - 0.042 13.7 0.1 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 UBA-like domain Arm-DNA-bind_4 PF14657.6 EDN05749.1 - 0.91 9.3 4.0 0.35 10.6 0.8 1.9 2 0 0 2 2 2 0 Arm DNA-binding domain DUF3328 PF11807.8 EDN05750.1 - 3e-46 157.9 0.0 3.8e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Glyco_hydro_47 PF01532.20 EDN05751.1 - 1e-137 459.8 0.0 1.1e-137 459.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GST_C PF00043.25 EDN05752.1 - 3.4e-16 59.2 0.0 7.5e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDN05752.1 - 2.8e-13 50.0 0.0 7e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDN05752.1 - 5.7e-12 45.7 0.0 1.9e-11 44.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDN05752.1 - 2.4e-11 43.9 0.0 5.6e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDN05752.1 - 2.7e-10 40.4 0.0 7.9e-10 38.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDN05752.1 - 2e-08 34.2 0.0 4.1e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EDN05752.1 - 0.094 13.5 0.0 0.2 12.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EDN05752.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ACC_epsilon PF13822.6 EDN05753.1 - 0.059 14.0 0.8 0.083 13.6 0.8 1.1 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Histidinol_dh PF00815.20 EDN05754.1 - 1.2e-160 535.0 5.4 2.2e-160 534.2 4.8 1.7 2 0 0 2 2 2 1 Histidinol dehydrogenase adh_short PF00106.25 EDN05754.1 - 3.4e-32 111.5 0.1 9.1e-32 110.1 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase PRA-CH PF01502.18 EDN05754.1 - 1.6e-24 85.5 0.4 3.6e-24 84.4 0.4 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase adh_short_C2 PF13561.6 EDN05754.1 - 5e-24 85.2 0.0 1.3e-23 83.8 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PRA-PH PF01503.17 EDN05754.1 - 1.5e-14 54.1 0.7 3.7e-14 52.9 0.1 1.9 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase KR PF08659.10 EDN05754.1 - 5.4e-05 23.2 0.2 0.00041 20.3 0.0 2.6 2 1 0 2 2 2 1 KR domain DUF659 PF04937.15 EDN05754.1 - 0.082 12.8 0.2 5.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF 659) Utp11 PF03998.13 EDN05755.1 - 1.7e-56 191.9 29.9 2e-56 191.7 29.9 1.1 1 0 0 1 1 1 1 Utp11 protein Cmc1 PF08583.10 EDN05756.1 - 8.5e-16 57.7 4.4 8.5e-16 57.7 4.4 2.0 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EDN05756.1 - 0.04 13.9 0.2 0.07 13.1 0.2 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Nucleo_P87 PF07267.11 EDN05756.1 - 0.95 8.2 6.4 1 8.2 6.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TFIID-31kDa PF02291.15 EDN05757.1 - 8e-44 148.6 0.0 1.1e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit LNS2 PF08235.13 EDN05758.1 - 3.2e-96 321.2 0.0 4.4e-96 320.7 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EDN05758.1 - 5.7e-43 145.0 0.0 1.3e-42 143.9 0.0 1.6 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EDN05758.1 - 0.0053 16.4 0.0 0.18 11.4 0.0 2.4 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Taxilin PF09728.9 EDN05759.1 - 1.3 8.1 40.1 11 5.0 40.2 2.1 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Cauli_AT PF03233.13 EDN05759.1 - 1.6 8.6 10.5 1.1 9.2 0.6 2.7 2 0 0 2 2 2 0 Aphid transmission protein RNA_pol_Rpb1_1 PF04997.12 EDN05761.1 - 3.4e-113 378.1 0.0 5e-113 377.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EDN05761.1 - 1.6e-104 349.1 0.1 2.4e-104 348.5 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDN05761.1 - 3.2e-75 251.9 0.0 5.9e-75 251.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EDN05761.1 - 1.2e-65 220.9 1.9 2.6e-65 219.9 1.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EDN05761.1 - 4e-47 160.1 0.0 1.1e-46 158.7 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EDN05761.1 - 6.5e-45 152.4 8.2 1.4e-44 151.3 8.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EDN05761.1 - 7.8e-37 125.5 0.1 1.7e-36 124.5 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EDN05761.1 - 9.8e-17 60.3 194.6 0.0034 17.7 0.6 13.9 12 1 1 13 13 13 12 RNA polymerase Rpb1 C-terminal repeat WD40 PF00400.32 EDN05762.1 - 2.4e-08 34.5 2.0 0.00026 21.7 0.0 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05762.1 - 2.8e-07 30.7 0.0 0.00014 22.1 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DDE_1 PF03184.19 EDN05764.1 - 2e-31 109.0 0.0 4.3e-31 107.9 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN05764.1 - 7.7e-11 41.9 0.0 2.1e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN05764.1 - 3.5e-07 29.9 0.1 9.4e-07 28.5 0.1 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN05764.1 - 0.00011 21.9 0.1 0.0051 16.6 0.0 2.6 2 0 0 2 2 2 1 DDE superfamily endonuclease MTS PF05175.14 EDN05765.1 - 0.00097 18.7 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDN05765.1 - 0.0039 17.9 0.0 0.0073 17.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN05765.1 - 0.01 15.7 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EDN05765.1 - 0.016 14.7 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_31 PF13847.6 EDN05765.1 - 0.018 14.8 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EDN05765.1 - 0.091 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase WD40 PF00400.32 EDN05767.1 - 1e-13 51.5 7.1 0.00048 20.9 0.1 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EDN05767.1 - 0.025 13.3 0.0 2.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Nup133 N terminal like Aldedh PF00171.22 EDN05768.1 - 1.1e-145 485.7 0.1 1.4e-145 485.4 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EDN05768.1 - 0.0096 15.0 0.0 0.021 13.9 0.0 1.5 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) NAD_binding_4 PF07993.12 EDN05769.1 - 9.9e-39 133.0 0.0 2.1e-38 132.0 0.0 1.5 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EDN05769.1 - 7.8e-36 123.6 0.1 4.5e-33 114.5 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Epimerase PF01370.21 EDN05769.1 - 1.3e-08 34.6 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EDN05769.1 - 1.8e-06 28.2 0.0 6.5e-06 26.4 0.1 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 EDN05769.1 - 0.036 13.2 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EDN05769.1 - 0.15 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sel1 PF08238.12 EDN05770.1 - 9.6e-33 111.9 31.2 4e-05 24.1 0.1 12.2 12 0 0 12 12 12 9 Sel1 repeat SUZ PF12752.7 EDN05771.1 - 0.0095 16.7 2.8 0.038 14.8 2.8 2.0 1 0 0 1 1 1 1 SUZ domain MBD PF01429.19 EDN05771.1 - 0.029 14.1 0.0 0.07 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyl-CpG binding domain Mei5 PF10376.9 EDN05772.1 - 0.00013 21.9 0.8 0.00026 20.9 0.8 1.4 1 0 0 1 1 1 1 Double-strand recombination repair protein Kelch_4 PF13418.6 EDN05773.1 - 7.1e-15 54.7 0.4 6.9e-07 29.2 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EDN05773.1 - 6.1e-13 48.7 0.3 1.6e-05 25.0 0.2 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EDN05773.1 - 1.5e-10 40.8 0.6 1.4e-05 24.9 0.1 3.0 3 0 0 3 3 3 2 Kelch motif BTB PF00651.31 EDN05773.1 - 3.7e-10 40.0 0.1 6.8e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 EDN05773.1 - 4.1e-10 39.6 0.1 0.001 19.3 0.1 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 EDN05773.1 - 9.6e-10 37.9 0.6 0.00014 21.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EDN05773.1 - 5e-09 35.8 0.1 4.2e-05 23.3 0.0 2.7 2 0 0 2 2 2 2 Kelch motif BACK PF07707.15 EDN05773.1 - 0.21 11.7 0.0 0.53 10.4 0.0 1.7 1 0 0 1 1 1 0 BTB And C-terminal Kelch WD40 PF00400.32 EDN05774.1 - 5.3e-16 58.7 14.7 0.00046 20.9 0.1 6.5 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05774.1 - 2.1e-15 56.8 3.9 7e-06 26.3 0.2 4.4 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN05774.1 - 8e-06 25.0 0.0 0.00085 18.4 0.0 3.1 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDN05774.1 - 0.00026 20.9 0.3 0.024 14.5 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A RT_RNaseH PF17917.1 EDN05776.1 - 1.5e-39 134.5 0.4 1.5e-39 134.5 0.4 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN05776.1 - 1e-34 118.5 0.0 3e-34 117.1 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN05776.1 - 1.4e-29 103.2 0.2 3.5e-29 101.9 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN05776.1 - 2.7e-19 69.0 0.1 6e-19 67.9 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EDN05776.1 - 4.1e-06 26.9 0.1 1.8e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 H2C2 zinc finger TSNAXIP1_N PF15739.5 EDN05776.1 - 0.046 14.1 6.1 0.22 11.9 0.3 2.9 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Asp_protease_2 PF13650.6 EDN05776.1 - 0.17 12.6 0.0 0.31 11.7 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease NDUFA12 PF05071.16 EDN05776.1 - 3.3 8.6 7.3 3.6 8.5 4.9 2.4 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 AAA_23 PF13476.6 EDN05776.1 - 5.2 7.5 8.7 17 5.9 3.0 2.6 2 0 0 2 2 2 0 AAA domain NYD-SP28 PF14772.6 EDN05776.1 - 9.1 6.4 9.6 0.14 12.2 0.3 2.7 3 0 0 3 3 3 0 Sperm tail TFIIA PF03153.13 EDN05777.1 - 1.3e-91 308.7 20.1 1.5e-91 308.5 20.1 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DFRP_C PF16543.5 EDN05777.1 - 0.14 12.7 0.1 0.14 12.7 0.1 1.8 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 zf-C2H2_aberr PF17017.5 EDN05778.1 - 2.7e-05 24.4 0.2 0.048 13.8 0.0 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 EDN05778.1 - 3.2e-05 24.1 10.2 0.067 13.7 1.4 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN05778.1 - 0.00015 22.3 12.1 0.034 15.0 1.1 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDN05778.1 - 0.0033 17.8 10.2 0.035 14.6 0.6 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDN05778.1 - 0.0077 16.5 0.6 0.89 9.9 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding DUF4719 PF15843.5 EDN05778.1 - 0.085 13.0 0.0 0.085 13.0 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4719) RNHCP PF12647.7 EDN05778.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 RNHCP domain zf-met PF12874.7 EDN05778.1 - 1.1 9.7 4.4 3.1 8.3 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 EDN05778.1 - 4.8 6.9 6.5 52 3.6 0.2 3.2 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Dus PF01207.17 EDN05780.1 - 8.8e-43 146.6 0.0 1.7e-30 106.2 0.2 3.0 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 EDN05780.1 - 0.00035 20.3 4.8 0.044 13.6 0.3 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EDN05780.1 - 0.046 13.8 10.2 0.17 12.0 1.3 2.5 2 0 0 2 2 2 0 Zinc finger domain Torus PF16131.5 EDN05780.1 - 0.12 13.1 10.7 0.21 12.3 1.9 2.8 2 1 1 3 3 3 0 Torus domain DUF4897 PF16238.5 EDN05780.1 - 0.16 11.8 0.0 2.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4897) zf-CCCH PF00642.24 EDN05780.1 - 0.17 11.9 4.0 1.7 8.6 0.5 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Bap31 PF05529.12 EDN05781.1 - 1e-49 167.8 6.2 1.3e-49 167.5 6.2 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EDN05781.1 - 8.6e-15 54.5 1.6 9.1e-15 54.4 0.4 1.7 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 EDN05781.1 - 0.00015 21.5 0.8 0.025 14.3 0.2 3.2 3 0 0 3 3 3 1 Septum formation initiator TMF_DNA_bd PF12329.8 EDN05781.1 - 0.024 14.6 0.8 0.024 14.6 0.8 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 EDN05781.1 - 0.025 15.2 1.3 0.16 12.6 0.1 2.4 3 0 0 3 3 3 0 SlyX MbeD_MobD PF04899.12 EDN05781.1 - 0.095 12.8 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 MbeD/MobD like DUF4349 PF14257.6 EDN05781.1 - 0.098 12.1 0.1 0.098 12.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) GPS2_interact PF15784.5 EDN05781.1 - 0.13 12.7 0.5 0.13 12.7 0.5 1.6 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Spc7 PF08317.11 EDN05781.1 - 0.16 10.8 0.4 0.25 10.2 0.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ZapB PF06005.12 EDN05781.1 - 0.37 11.3 2.3 0.8 10.2 0.2 2.3 3 0 0 3 3 3 0 Cell division protein ZapB bZIP_1 PF00170.21 EDN05781.1 - 0.51 10.5 2.9 5.2 7.3 0.6 2.4 2 0 0 2 2 2 0 bZIP transcription factor MMM1 PF10296.9 EDN05782.1 - 6e-05 22.3 0.0 0.00017 20.7 0.0 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 DDE_3 PF13358.6 EDN05783.1 - 6.4e-11 42.2 0.3 9.8e-11 41.6 0.3 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease T4_baseplate PF12322.8 EDN05783.1 - 0.027 13.9 0.1 0.03 13.8 0.1 1.1 1 0 0 1 1 1 0 T4 bacteriophage base plate protein Chromo PF00385.24 EDN05785.1 - 3.8e-06 26.7 0.5 0.047 13.6 0.2 3.4 3 1 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain Pkinase_fungal PF17667.1 EDN05787.1 - 1.7e-135 451.9 0.5 3.1e-135 451.1 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 EDN05787.1 - 6.8e-07 28.9 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN05787.1 - 0.0081 16.1 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EDN05787.1 - 0.026 13.8 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase AAA PF00004.29 EDN05788.1 - 2.5e-06 28.0 0.0 9.6e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SET_assoc PF11767.8 EDN05788.1 - 0.11 12.2 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated pP_pnuc_1 PF18165.1 EDN05788.1 - 0.17 11.8 1.5 0.4 10.6 1.5 1.5 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease POX PF07526.11 EDN05788.1 - 0.45 11.1 4.0 0.37 11.4 1.6 2.0 2 0 0 2 2 2 0 Associated with HOX DUF765 PF05570.11 EDN05790.1 - 0.72 10.1 4.6 3.2 8.0 1.4 2.8 2 0 0 2 2 2 0 Circovirus protein of unknown function (DUF765) BCS1_N PF08740.11 EDN05792.1 - 3.7e-35 121.6 0.0 6.1e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN05792.1 - 3.5e-20 72.8 0.0 1.5e-19 70.7 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN05792.1 - 7.1e-05 23.3 0.0 0.00016 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 EDN05792.1 - 0.029 13.7 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EDN05792.1 - 0.033 13.8 0.0 0.084 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN05792.1 - 0.04 14.1 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EDN05792.1 - 0.05 12.4 0.0 0.097 11.5 0.0 1.4 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 EDN05792.1 - 0.094 12.4 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN05792.1 - 0.14 12.1 0.0 0.41 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Myb_DNA-binding PF00249.31 EDN05793.1 - 9.2e-15 54.6 3.7 4.2e-10 39.7 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05793.1 - 1.1e-06 28.7 0.4 0.00094 19.4 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain WRC PF08879.10 EDN05794.1 - 0.0069 16.1 0.3 0.014 15.1 0.3 1.5 1 0 0 1 1 1 1 WRC DUF3435 PF11917.8 EDN05795.1 - 3.7e-163 543.3 0.0 4.7e-163 543.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2_4 PF13894.6 EDN05795.1 - 0.13 13.2 6.7 3.5 8.7 0.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EDN05795.1 - 0.17 12.6 0.7 0.44 11.2 0.7 1.7 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats FSIP1 PF15554.6 EDN05796.1 - 0.16 11.1 0.1 0.17 10.9 0.1 1.0 1 0 0 1 1 1 0 FSIP1 family Pkinase PF00069.25 EDN05797.1 - 1.8e-44 152.1 0.0 3.3e-44 151.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05797.1 - 1.7e-19 70.1 0.0 9.1e-14 51.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDN05797.1 - 2.4e-06 27.1 0.0 0.0041 16.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EDN05797.1 - 0.00018 21.5 0.0 0.00033 20.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDN05797.1 - 0.054 12.4 0.0 0.14 11.1 0.0 1.6 1 0 0 1 1 1 0 Haspin like kinase domain Ank_2 PF12796.7 EDN05799.1 - 4.6e-31 107.2 1.5 1.9e-08 34.8 0.0 9.5 8 1 1 9 9 9 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN05799.1 - 2.8e-26 91.2 0.1 5e-05 23.5 0.0 10.3 10 1 2 12 12 12 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN05799.1 - 2.5e-24 85.3 4.0 6.1e-05 23.5 0.0 10.0 8 1 1 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN05799.1 - 1.5e-21 74.1 4.4 0.092 13.4 0.0 12.3 12 0 0 12 12 12 4 Ankyrin repeat Ank PF00023.30 EDN05799.1 - 1.3e-15 57.0 7.8 0.02 15.3 0.0 7.7 8 0 0 8 8 8 5 Ankyrin repeat DUF1843 PF08898.10 EDN05799.1 - 0.006 17.0 0.0 26 5.4 0.0 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF1843) Senescence PF06911.12 EDN05801.1 - 3.4e-54 183.9 4.9 5.1e-54 183.4 4.9 1.3 1 0 0 1 1 1 1 Senescence-associated protein TyrRSs_C PF16714.5 EDN05801.1 - 0.065 13.0 0.5 2 8.2 0.1 2.4 1 1 1 2 2 2 0 Tyrosyl-tRNA synthetase C-terminal domain Acyl-CoA_dh_1 PF00441.24 EDN05802.1 - 6.6e-39 133.5 8.8 8.4e-39 133.2 8.8 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDN05802.1 - 2.8e-17 63.4 2.6 1.1e-16 61.5 0.1 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EDN05802.1 - 4.3e-17 62.6 4.7 5.9e-17 62.2 4.7 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cupin_2 PF07883.11 EDN05804.1 - 5.2e-05 22.9 0.0 8.6e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EDN05804.1 - 0.0011 18.6 0.1 0.0023 17.6 0.0 1.5 2 0 0 2 2 2 1 Cupin Cupin_3 PF05899.12 EDN05804.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) GWT1 PF06423.12 EDN05805.1 - 1e-41 142.5 3.5 1.2e-41 142.3 1.0 2.2 2 1 1 3 3 3 1 GWT1 DUF4818 PF16089.5 EDN05805.1 - 0.037 14.5 0.0 0.22 12.0 0.0 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4818) DUF2871 PF11070.8 EDN05805.1 - 0.049 13.9 0.1 15 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2871) Amidase PF01425.21 EDN05806.1 - 2.6e-77 260.7 0.1 6.1e-77 259.5 0.1 1.5 1 1 0 1 1 1 1 Amidase PDEase_II PF02112.15 EDN05807.1 - 2.5e-56 191.2 0.0 2.7e-46 158.2 0.0 3.0 2 1 0 2 2 2 2 cAMP phosphodiesterases class-II Lactamase_B PF00753.27 EDN05807.1 - 0.0018 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDN05807.1 - 0.0066 16.0 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DXP_redisom_C PF08436.12 EDN05807.1 - 0.18 12.0 0.0 0.69 10.1 0.0 2.0 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain SPRY PF00622.28 EDN05808.1 - 1.2e-15 57.7 0.1 5.4e-14 52.3 0.1 2.5 1 1 0 1 1 1 1 SPRY domain Peptidase_M24 PF00557.24 EDN05810.1 - 9e-58 195.4 0.0 1.3e-57 194.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDN05810.1 - 7.5e-21 74.1 0.0 1.3e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Agglutinin_C PF18021.1 EDN05810.1 - 0.085 13.4 0.0 0.92 10.1 0.0 2.3 2 0 0 2 2 2 0 Agglutinin C-terminal Peptidase_M10 PF00413.24 EDN05810.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.5 1 1 0 1 1 1 0 Matrixin DnaJ PF00226.31 EDN05812.1 - 9.7e-15 54.4 0.4 2.7e-14 53.0 0.4 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EDN05812.1 - 5.7e-10 38.8 0.0 2.5e-05 23.6 0.0 2.1 2 0 0 2 2 2 2 Sec63 Brl domain RinB PF06116.12 EDN05813.1 - 0.17 12.0 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Transcriptional activator RinB Fungal_trans PF04082.18 EDN05814.1 - 1.3e-08 34.2 0.1 2.2e-08 33.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain SAM_2 PF07647.17 EDN05816.1 - 0.0085 16.2 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) HMG_box PF00505.19 EDN05816.1 - 0.0099 16.3 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box SAM_1 PF00536.30 EDN05816.1 - 0.044 14.2 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pkinase PF00069.25 EDN05817.1 - 4.8e-21 75.3 0.0 5.1e-11 42.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN05817.1 - 0.0076 15.6 0.0 0.45 9.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PsbH PF00737.20 EDN05817.1 - 0.05 13.3 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein ALO PF04030.14 EDN05819.1 - 9.4e-86 287.8 0.0 1.4e-85 287.2 0.0 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EDN05819.1 - 2.2e-30 105.2 0.0 3.3e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Gelsolin PF00626.22 EDN05820.1 - 4.6e-11 42.4 0.0 0.0053 16.6 0.0 3.4 3 0 0 3 3 3 3 Gelsolin repeat WD40_4 PF16300.5 EDN05820.1 - 0.07 13.0 0.5 0.14 12.1 0.5 1.4 1 0 0 1 1 1 0 Type of WD40 repeat DUF4045 PF13254.6 EDN05821.1 - 4.6e-87 293.4 27.4 4.6e-87 293.4 27.4 3.8 3 1 1 4 4 4 1 Domain of unknown function (DUF4045) Arf PF00025.21 EDN05822.1 - 2.7e-66 222.3 0.8 3e-66 222.2 0.8 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EDN05822.1 - 2.3e-12 46.8 0.0 2.6e-12 46.6 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDN05822.1 - 4.7e-12 45.8 1.3 8.1e-08 31.8 0.3 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EDN05822.1 - 5.2e-12 46.0 0.1 7.3e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EDN05822.1 - 6.2e-11 42.1 0.0 7.5e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDN05822.1 - 4.7e-08 33.1 0.0 6.9e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EDN05822.1 - 2e-06 27.4 0.0 2.6e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EDN05822.1 - 4.7e-06 26.3 0.0 8.3e-05 22.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EDN05822.1 - 0.034 13.7 0.2 0.13 11.7 0.2 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B NACHT PF05729.12 EDN05822.1 - 0.071 13.0 0.1 0.94 9.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Acetyltransf_1 PF00583.25 EDN05823.1 - 0.0025 18.0 0.0 0.0071 16.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN05823.1 - 0.0053 17.2 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1501 PF07394.12 EDN05823.1 - 0.024 13.7 0.1 0.044 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Acetyltransf_10 PF13673.7 EDN05823.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GlgX_C PF18390.1 EDN05823.1 - 0.13 12.1 0.2 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 Glycogen debranching enzyme C-terminal domain Glyco_hydro_61 PF03443.14 EDN05824.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 61 HMGL-like PF00682.19 EDN05825.1 - 9.9e-81 271.2 0.0 8.9e-80 268.0 0.0 2.2 2 0 0 2 2 2 1 HMGL-like DEAD PF00270.29 EDN05825.1 - 1.1e-46 158.9 0.0 1.9e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN05825.1 - 1.2e-30 106.1 0.6 1.9e-28 99.0 0.1 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain LeuA_dimer PF08502.10 EDN05825.1 - 3.6e-11 43.1 0.6 1.4e-09 38.0 0.7 2.5 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain UTP25 PF06862.12 EDN05825.1 - 0.0011 17.8 1.2 0.0038 16.1 0.1 2.3 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AMP-binding PF00501.28 EDN05826.1 - 3.1e-51 174.3 0.3 5.9e-27 94.3 0.0 3.6 3 1 0 3 3 3 3 AMP-binding enzyme DMAP_binding PF06464.11 EDN05826.1 - 5.4e-07 30.4 0.0 3.2e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.12 EDN05826.1 - 0.0049 16.8 0.4 0.018 15.0 0.4 1.8 2 0 0 2 2 2 1 Gas vesicle protein G Ribosomal_S7 PF00177.21 EDN05827.1 - 2.6e-36 124.5 2.0 3.2e-36 124.2 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e SDA1 PF05285.12 EDN05828.1 - 5.7e-90 302.2 46.8 5.7e-90 302.2 46.8 2.7 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EDN05828.1 - 6.3e-23 80.9 0.4 1.9e-22 79.3 0.1 2.1 2 0 0 2 2 2 1 NUC130/3NT domain RNR_inhib PF08591.10 EDN05829.1 - 2.1e-08 35.4 2.3 6.7e-08 33.8 0.1 2.3 2 1 0 2 2 2 1 Ribonucleotide reductase inhibitor Chlorosome_CsmC PF11098.8 EDN05830.1 - 0.33 10.9 0.8 2.8 7.9 0.0 2.2 2 0 0 2 2 2 0 Chlorosome envelope protein C vATP-synt_AC39 PF01992.16 EDN05831.1 - 2.1e-103 346.4 0.0 2.4e-103 346.2 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Nop PF01798.18 EDN05832.1 - 4.9e-81 271.6 0.1 4.9e-81 271.6 0.1 2.2 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDN05832.1 - 2.8e-21 75.6 1.9 2.8e-21 75.6 1.9 2.8 3 0 0 3 3 3 1 NOP5NT (NUC127) domain WDCP PF15390.6 EDN05832.1 - 3.1 6.1 11.8 4.7 5.5 11.8 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Vpu PF00558.19 EDN05832.1 - 4.6 7.1 5.5 18 5.2 5.5 2.0 1 0 0 1 1 1 0 Vpu protein RNA_pol_Rpb4 PF03874.16 EDN05833.1 - 6.8e-07 29.7 3.9 0.00038 20.8 0.4 2.5 3 0 0 3 3 3 2 RNA polymerase Rpb4 DEDD_Tnp_IS110 PF01548.17 EDN05835.1 - 0.044 13.7 0.4 0.12 12.2 0.4 1.7 1 0 0 1 1 1 0 Transposase DUF2894 PF11445.8 EDN05835.1 - 0.049 14.1 3.7 0.65 10.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2894) MVL PF12151.8 EDN05835.1 - 0.11 12.4 1.3 0.28 11.1 1.3 1.7 1 0 0 1 1 1 0 Mannan-binding protein Herpes_capsid PF06112.11 EDN05835.1 - 5.8 7.0 10.1 44 4.1 7.7 2.5 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein PARP PF00644.20 EDN05836.1 - 1e-09 38.3 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 EDN05836.1 - 7.2e-08 32.2 0.0 1.9e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDN05836.1 - 0.025 14.8 0.0 0.22 11.8 0.0 2.4 2 0 0 2 2 2 0 RWD domain adh_short PF00106.25 EDN05837.1 - 8.2e-28 97.2 0.0 1.3e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN05837.1 - 9.7e-19 67.8 0.0 1.5e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN05837.1 - 7.3e-08 32.5 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EDN05837.1 - 0.00021 20.8 0.0 0.00043 19.7 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) WD40 PF00400.32 EDN05838.1 - 3.6e-21 75.1 8.7 1.3e-05 25.8 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05838.1 - 3.1e-07 30.6 0.0 0.28 11.5 0.0 3.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN05838.1 - 0.0052 15.8 0.0 0.029 13.4 0.0 2.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein RPN6_N PF18055.1 EDN05839.1 - 7.2e-46 155.3 0.1 2.5e-45 153.6 0.1 2.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EDN05839.1 - 3.4e-22 78.9 1.2 6.6e-22 78.0 0.2 2.0 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 EDN05839.1 - 2.5e-10 39.9 2.9 2.7e-10 39.8 0.5 2.3 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_MalT PF17874.1 EDN05839.1 - 3.9e-07 29.8 4.1 3.6e-06 26.6 1.9 2.7 1 1 1 3 3 3 1 MalT-like TPR region TPR_12 PF13424.6 EDN05839.1 - 2.3e-05 24.6 15.0 0.003 17.8 1.4 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDN05839.1 - 0.00011 22.0 2.0 2.6 8.3 0.0 5.3 6 1 0 6 6 6 1 Tetratricopeptide repeat DDRGK PF09756.9 EDN05839.1 - 0.00019 21.1 0.3 0.00032 20.3 0.3 1.3 1 0 0 1 1 1 1 DDRGK domain TPR_2 PF07719.17 EDN05839.1 - 0.024 14.7 5.1 36 4.8 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat DprA_WH PF17782.1 EDN05839.1 - 0.046 13.8 0.0 0.53 10.4 0.0 2.4 2 0 0 2 2 2 0 DprA winged helix domain TPR_4 PF07721.14 EDN05839.1 - 0.075 13.7 0.1 1.9 9.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4606 PF15379.6 EDN05839.1 - 0.2 11.9 0.5 8.8 6.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4606) TPR_6 PF13174.6 EDN05839.1 - 0.3 11.8 8.4 1.6e+02 3.3 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF4398 PF14346.6 EDN05839.1 - 0.34 11.6 3.3 1.6 9.4 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) TPR_1 PF00515.28 EDN05839.1 - 1.4 8.9 9.3 3.1 7.8 0.1 5.0 7 1 0 7 7 6 0 Tetratricopeptide repeat Mpv17_PMP22 PF04117.12 EDN05840.1 - 3.4e-13 49.6 0.9 1.3e-11 44.6 0.8 2.3 2 0 0 2 2 2 1 Mpv17 / PMP22 family NADH_oxidored PF08040.11 EDN05840.1 - 0.14 11.9 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 MNLL subunit HTH_7 PF02796.15 EDN05841.1 - 1.9e-07 31.0 0.0 5.1e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN05841.1 - 2.7e-06 27.0 0.0 0.00011 21.9 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN05841.1 - 5.8e-06 25.9 0.0 3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_29 PF13551.6 EDN05841.1 - 7.4e-06 25.9 0.0 5.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN05841.1 - 5.5e-05 22.8 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN05841.1 - 0.00018 21.4 0.0 0.00029 20.8 0.0 1.3 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN05841.1 - 0.0071 16.9 0.0 1.2 9.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 EDN05841.1 - 0.036 13.6 0.5 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN05841.1 - 0.047 13.8 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN05841.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN05841.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein SDA1 PF05285.12 EDN05842.1 - 0.015 14.8 7.9 0.016 14.6 7.9 1.1 1 0 0 1 1 1 0 SDA1 DUF3381 PF11861.8 EDN05842.1 - 0.017 14.9 5.7 3 7.6 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) CDC45 PF02724.14 EDN05842.1 - 0.044 12.1 4.4 0.044 12.1 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EDN05842.1 - 0.05 11.8 8.2 0.051 11.8 8.2 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 EDN05842.1 - 0.085 12.5 6.3 0.12 12.0 6.3 1.3 1 0 0 1 1 1 0 FAM176 family RPN2_C PF18004.1 EDN05842.1 - 0.096 12.6 7.9 0.14 12.1 7.9 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain eIF-3c_N PF05470.12 EDN05842.1 - 0.18 10.1 3.7 0.16 10.2 3.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus NOA36 PF06524.12 EDN05842.1 - 0.19 11.0 11.4 0.23 10.7 11.4 1.1 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 EDN05842.1 - 0.26 10.5 6.7 0.33 10.1 6.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.12 EDN05842.1 - 0.45 9.9 10.9 0.61 9.4 10.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 EDN05842.1 - 0.54 9.4 1.1 0.48 9.6 1.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIF_alpha PF05793.12 EDN05842.1 - 0.56 8.7 12.9 0.69 8.4 12.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 EDN05842.1 - 0.89 8.2 2.0 0.75 8.5 2.0 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 EDN05842.1 - 1.6 7.4 7.3 2 7.1 7.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_Ag35 PF03286.14 EDN05842.1 - 2 8.2 12.0 2.6 7.8 12.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TFB6 PF17110.5 EDN05842.1 - 2.2 8.0 5.6 2.9 7.6 5.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RRN3 PF05327.11 EDN05842.1 - 3.2 6.2 4.4 3.6 6.0 4.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EDN05842.1 - 3.3 5.7 15.8 4.1 5.4 15.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 EDN05842.1 - 4 7.2 12.1 6.7 6.4 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) NESP55 PF06390.12 EDN05842.1 - 5.9 6.4 24.9 0.19 11.3 3.0 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) Sporozoite_P67 PF05642.11 EDN05842.1 - 8.7 4.3 9.3 12 3.9 9.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Radial_spoke PF04712.12 EDN05842.1 - 9.3 5.1 15.2 13 4.6 15.2 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein Mt_ATP-synt_B PF05405.14 EDN05844.1 - 0.11 12.2 0.2 0.14 11.8 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) RVT_1 PF00078.27 EDN05845.1 - 1.1e-40 139.5 0.0 1.6e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN05845.1 - 1.5e-13 50.6 0.0 5.1e-13 48.9 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN05845.1 - 2.3e-05 24.0 0.0 4.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SIKE PF05769.11 EDN05846.1 - 0.048 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 SIKE family PEX11 PF05648.14 EDN05847.1 - 8.1e-14 51.6 0.0 3.9e-09 36.3 0.0 2.2 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) AAA PF00004.29 EDN05849.1 - 2.3e-95 316.0 0.0 8.9e-47 158.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN05849.1 - 3.9e-23 81.0 4.3 6.6e-13 48.2 0.3 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EDN05849.1 - 3.7e-17 62.3 0.4 9.6e-17 60.9 0.4 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EDN05849.1 - 2.1e-13 50.8 0.0 3.6e-07 30.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDN05849.1 - 5.7e-13 48.9 0.0 8e-05 22.4 0.0 3.3 4 1 0 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EDN05849.1 - 2.3e-12 47.3 0.0 1.1e-05 25.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDN05849.1 - 6.3e-11 43.0 0.0 0.00026 21.4 0.0 4.3 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 EDN05849.1 - 1.9e-10 40.9 0.4 4.5e-05 23.5 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN05849.1 - 7.8e-09 35.9 0.4 0.065 13.5 0.0 4.2 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 EDN05849.1 - 4.1e-08 32.8 0.0 0.0085 15.3 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain IstB_IS21 PF01695.17 EDN05849.1 - 5.5e-07 29.5 0.0 0.02 14.6 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDN05849.1 - 9.3e-07 28.4 0.3 0.033 13.6 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDN05849.1 - 9.4e-07 29.4 0.0 0.053 14.1 0.0 2.8 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EDN05849.1 - 1.6e-06 28.5 0.0 0.031 14.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EDN05849.1 - 2.4e-06 27.6 0.0 0.024 14.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 EDN05849.1 - 6.8e-06 26.0 0.1 8e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 EDN05849.1 - 2e-05 24.2 0.1 0.03 13.8 0.0 3.1 2 2 0 2 2 2 1 P-loop containing dynein motor region ATPase PF06745.13 EDN05849.1 - 2.3e-05 23.9 0.5 0.67 9.3 0.0 3.4 3 0 0 3 3 3 1 KaiC PhoH PF02562.16 EDN05849.1 - 2.3e-05 24.0 0.3 0.19 11.1 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_28 PF13521.6 EDN05849.1 - 4.5e-05 23.7 0.0 0.3 11.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EDN05849.1 - 5.2e-05 23.8 0.0 0.26 11.8 0.0 3.3 2 1 0 2 2 2 1 ABC transporter Bac_DnaA PF00308.18 EDN05849.1 - 5.9e-05 23.0 0.0 0.36 10.6 0.0 3.3 4 0 0 4 4 3 2 Bacterial dnaA protein AAA_25 PF13481.6 EDN05849.1 - 6.2e-05 22.7 5.4 0.43 10.1 0.1 4.7 3 2 1 5 5 5 1 AAA domain AAA_24 PF13479.6 EDN05849.1 - 0.00014 21.7 0.0 0.66 9.7 0.0 2.8 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 EDN05849.1 - 0.00019 20.6 0.1 0.1 11.7 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 EDN05849.1 - 0.00023 20.9 0.1 1.3 8.8 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.6 EDN05849.1 - 0.00034 21.1 0.1 0.86 10.0 0.0 3.3 3 1 0 3 3 2 1 AAA domain ResIII PF04851.15 EDN05849.1 - 0.00061 19.8 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF815 PF05673.13 EDN05849.1 - 0.00064 19.0 0.0 0.04 13.1 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 EDN05849.1 - 0.00092 19.2 0.0 0.64 10.0 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 EDN05849.1 - 0.0012 18.2 0.0 0.84 8.8 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EDN05849.1 - 0.0019 18.1 0.0 0.85 9.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EDN05849.1 - 0.0019 18.2 0.0 3.3 7.6 0.0 3.5 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_3 PF07726.11 EDN05849.1 - 0.0021 17.9 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDN05849.1 - 0.0041 16.9 0.5 2.5 7.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDN05849.1 - 0.0065 16.4 0.1 1.7 8.5 0.0 2.9 3 0 0 3 3 3 1 NACHT domain Sigma54_activ_2 PF14532.6 EDN05849.1 - 0.0094 16.1 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 EDN05849.1 - 0.01 15.0 0.0 1.9 7.6 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Viral_helicase1 PF01443.18 EDN05849.1 - 0.011 15.4 0.0 0.65 9.7 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EDN05849.1 - 0.013 15.9 1.2 6.8 7.0 0.0 3.4 3 1 0 4 4 2 0 AAA domain NTPase_1 PF03266.15 EDN05849.1 - 0.013 15.5 0.4 4 7.3 0.0 3.4 3 0 0 3 3 3 0 NTPase Zeta_toxin PF06414.12 EDN05849.1 - 0.013 14.8 0.0 5.4 6.2 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin KAP_NTPase PF07693.14 EDN05849.1 - 0.021 14.1 0.0 0.91 8.7 0.0 2.6 2 1 0 2 2 2 0 KAP family P-loop domain IPT PF01745.16 EDN05849.1 - 0.075 12.4 0.1 6.1 6.2 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Cytidylate_kin2 PF13189.6 EDN05849.1 - 0.085 13.0 0.0 3.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_6 PF12774.7 EDN05849.1 - 0.12 11.3 0.1 11 4.8 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Zot PF05707.12 EDN05849.1 - 0.13 11.9 0.0 6.3 6.4 0.0 3.0 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AFG1_ATPase PF03969.16 EDN05849.1 - 0.14 11.1 0.0 3.6 6.4 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase PIF1 PF05970.14 EDN05849.1 - 0.14 11.3 0.0 16 4.5 0.0 2.5 2 0 0 2 2 2 0 PIF1-like helicase SAM_2 PF07647.17 EDN05850.1 - 6.2e-15 55.1 0.0 1e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EDN05850.1 - 3.8e-13 49.9 0.0 1.7e-12 47.8 0.0 2.1 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 EDN05850.1 - 3.9e-13 49.6 0.0 6.9e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EDN05850.1 - 0.0081 16.1 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Nha1_C PF08619.10 EDN05851.1 - 4.8e-81 273.3 31.7 2.1e-80 271.2 31.7 1.9 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EDN05851.1 - 1.1e-73 248.2 21.6 1.3e-73 248.0 21.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 EDN05851.1 - 0.02 15.0 1.3 0.086 12.9 1.3 2.1 1 0 0 1 1 1 0 YrhC-like protein PX PF00787.24 EDN05852.1 - 1.1e-16 60.8 0.3 2.7e-16 59.5 0.3 1.7 1 0 0 1 1 1 1 PX domain AAA PF00004.29 EDN05852.1 - 8.9e-09 35.9 0.1 1.3e-07 32.1 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDN05852.1 - 6.8e-07 29.4 0.1 2.1e-05 24.5 0.0 2.8 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 EDN05852.1 - 0.00014 22.3 0.0 0.00086 19.7 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDN05852.1 - 0.00094 19.5 0.0 0.0037 17.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDN05852.1 - 0.0014 18.8 0.6 0.56 10.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EDN05852.1 - 0.0045 16.2 0.0 0.0093 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EDN05852.1 - 0.012 14.9 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain RuvB_N PF05496.12 EDN05852.1 - 0.013 15.3 0.0 0.055 13.2 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN05852.1 - 0.016 15.8 0.0 0.068 13.7 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN05852.1 - 0.055 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Tmemb_cc2 PF10267.9 EDN05852.1 - 0.056 12.6 0.6 0.14 11.2 0.6 1.7 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RNA_helicase PF00910.22 EDN05852.1 - 0.13 12.7 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EDN05852.1 - 0.16 11.8 0.0 0.44 10.4 0.0 1.7 2 0 0 2 2 2 0 NTPase Prefoldin_3 PF13758.6 EDN05852.1 - 1.1 9.3 2.8 0.85 9.7 0.2 2.2 2 0 0 2 2 2 0 Prefoldin subunit Utp8 PF10395.9 EDN05853.1 - 1.5e-09 37.0 1.6 4e-06 25.7 0.0 3.7 3 1 0 3 3 3 3 Utp8 family zf-C2H2 PF00096.26 EDN05854.1 - 5.8e-09 35.9 16.2 0.00015 22.0 2.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN05854.1 - 1.8e-06 28.1 7.1 1.8e-06 28.1 7.1 2.9 2 0 0 2 2 2 1 Zinc-finger double domain Fungal_trans PF04082.18 EDN05854.1 - 0.00024 20.2 0.1 0.13 11.2 0.1 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 EDN05854.1 - 0.00026 21.6 15.4 0.029 15.2 2.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EDN05854.1 - 0.91 9.3 14.7 0.4 10.5 3.4 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type Fer4_10 PF13237.6 EDN05854.1 - 2 8.6 6.2 11 6.3 6.3 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain CAF1C_H4-bd PF12265.8 EDN05856.1 - 4.4e-15 55.7 0.0 2.5e-14 53.3 0.0 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDN05856.1 - 9.4e-11 42.1 2.0 0.0012 19.6 0.1 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05856.1 - 2.6e-06 27.7 0.1 0.019 15.2 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Suf PF05843.14 EDN05857.1 - 0.054 13.5 9.8 0.07 13.1 9.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 EDN05857.1 - 0.18 10.5 1.5 0.18 10.4 1.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 EDN05857.1 - 0.92 9.4 14.6 1.2 9.0 14.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 EDN05857.1 - 0.97 8.1 2.2 1.1 8.0 2.2 1.1 1 0 0 1 1 1 0 Presenilin Transglut_core PF01841.19 EDN05858.1 - 1.1e-13 51.6 0.0 2e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 EDN05858.1 - 0.11 12.0 0.0 1.4 8.5 0.0 2.1 1 1 0 1 1 1 0 Transglutaminase-like domain HTH_32 PF13565.6 EDN05860.1 - 0.00037 21.1 1.2 0.023 15.3 0.1 2.1 1 1 1 2 2 2 2 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EDN05860.1 - 0.18 11.5 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 Sugar_tr PF00083.24 EDN05861.1 - 2.2e-104 349.8 16.0 5.1e-104 348.6 16.0 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN05861.1 - 2.1e-26 92.7 55.1 2.6e-23 82.5 25.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily SET PF00856.28 EDN05862.1 - 1.6e-10 41.7 0.0 2.8e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 SET domain Zn_clus PF00172.18 EDN05863.1 - 1.1e-06 28.6 12.4 2.3e-06 27.6 12.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 EDN05864.1 - 2.2e-11 43.6 0.0 2.9e-06 26.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Prenyltrans PF00432.21 EDN05865.1 - 0.063 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat Glyco_hydro_127 PF07944.12 EDN05866.1 - 9.5e-14 50.8 0.0 1.2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 TRAM_LAG1_CLN8 PF03798.16 EDN05867.1 - 8.8e-37 126.8 17.1 8.8e-37 126.8 17.1 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EDN05867.1 - 4.2e-23 80.8 1.0 5.9e-23 80.3 0.0 1.8 2 0 0 2 2 2 1 TRAM1-like protein TFIIF_alpha PF05793.12 EDN05868.1 - 0.62 8.6 20.2 0.66 8.5 20.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SpoIIIAH PF12685.7 EDN05868.1 - 1.8 8.4 13.7 9.8 5.9 13.7 2.1 1 1 0 1 1 1 0 SpoIIIAH-like protein TIP120 PF08623.10 EDN05869.1 - 1.1e-60 204.3 0.6 6.2e-58 195.3 0.0 3.9 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 EDN05869.1 - 1.1e-16 60.9 8.8 0.0023 18.3 0.0 8.2 6 2 1 7 7 7 4 HEAT repeats HEAT PF02985.22 EDN05869.1 - 7e-14 50.8 14.6 1.4 9.4 0.0 11.2 12 0 0 12 12 12 3 HEAT repeat HEAT_EZ PF13513.6 EDN05869.1 - 3e-07 30.8 20.3 0.58 10.7 0.0 11.0 12 1 1 13 13 12 1 HEAT-like repeat Cnd1 PF12717.7 EDN05869.1 - 0.00025 21.1 0.7 0.061 13.4 0.0 4.1 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDN05869.1 - 0.00034 21.1 0.0 0.4 11.3 0.0 5.0 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EDN05869.1 - 0.00043 19.0 7.3 4.4 5.8 0.1 6.1 4 3 1 6 6 6 1 Adaptin N terminal region DUF5578 PF17741.1 EDN05869.1 - 0.00043 19.8 0.7 0.14 11.5 0.1 3.8 4 0 0 4 4 4 1 Family of unknown function (DUF5578) RTP1_C1 PF10363.9 EDN05869.1 - 0.00056 20.1 6.3 0.00097 19.3 0.1 4.1 6 0 0 6 6 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 EDN05869.1 - 0.0024 18.4 0.2 0.35 11.7 0.1 4.8 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat UME PF08064.13 EDN05869.1 - 0.0061 16.5 1.6 2.2 8.3 0.0 5.2 6 1 1 7 7 6 1 UME (NUC010) domain ParcG PF10274.9 EDN05869.1 - 0.014 15.5 4.2 31 4.6 0.0 5.5 5 1 1 6 6 6 0 Parkin co-regulated protein PSY3 PF16836.5 EDN05869.1 - 0.017 14.7 0.1 0.043 13.3 0.1 1.6 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description DUF3295 PF11702.8 EDN05869.1 - 0.032 13.6 1.1 0.056 12.8 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) CLASP_N PF12348.8 EDN05869.1 - 0.093 12.3 0.1 2 7.9 0.0 3.2 4 0 0 4 4 4 0 CLASP N terminal DRIM PF07539.12 EDN05869.1 - 0.14 10.4 9.5 9.6 4.4 0.3 4.7 4 1 1 5 5 5 0 Down-regulated in metastasis MMS19_C PF12460.8 EDN05869.1 - 9.8 5.2 21.4 3.3 6.7 0.9 5.4 5 1 0 5 5 5 0 RNAPII transcription regulator C-terminal PalH PF08733.10 EDN05874.1 - 2.9e-101 338.8 0.5 3.5e-101 338.5 0.5 1.1 1 0 0 1 1 1 1 PalH/RIM21 SSrecog PF03531.14 EDN05875.1 - 0.0016 18.3 0.0 0.0043 16.9 0.0 1.7 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) F-box-like PF12937.7 EDN05875.1 - 0.017 15.0 0.5 0.017 15.0 0.5 2.0 2 0 0 2 2 2 0 F-box-like DUF446 PF04287.12 EDN05876.1 - 0.17 12.0 1.7 0.44 10.6 1.7 1.7 1 0 0 1 1 1 0 tRNA pseudouridine synthase C Atg14 PF10186.9 EDN05878.1 - 4.8e-16 58.7 19.2 1.6e-13 50.5 19.2 2.4 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EDN05878.1 - 3.3e-13 49.3 2.4 4.4e-07 29.1 0.1 3.3 3 0 0 3 3 3 3 Vacuolar protein sorting 38 ISG65-75 PF11727.8 EDN05878.1 - 0.02 14.1 2.5 0.038 13.2 2.5 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein FH2 PF02181.23 EDN05878.1 - 0.03 13.5 4.9 0.052 12.7 4.9 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain Spc7 PF08317.11 EDN05878.1 - 0.037 12.9 9.8 0.058 12.3 9.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec8_exocyst PF04048.14 EDN05878.1 - 0.11 12.4 5.7 5.8 6.8 0.1 2.5 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain Exonuc_VII_L PF02601.15 EDN05878.1 - 0.25 10.8 7.7 0.44 10.1 7.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Snapin_Pallidin PF14712.6 EDN05878.1 - 0.26 11.7 5.4 0.69 10.4 5.4 1.7 1 0 0 1 1 1 0 Snapin/Pallidin IFT57 PF10498.9 EDN05878.1 - 0.85 8.5 6.8 1.3 7.9 6.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 TPR_MLP1_2 PF07926.12 EDN05878.1 - 1.1 9.4 13.3 2.6 8.1 12.9 1.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DivIVA PF05103.13 EDN05878.1 - 2.4 8.3 8.5 2.5 8.2 7.1 1.7 1 1 0 1 1 1 0 DivIVA protein Mhr1 PF12829.7 EDN05879.1 - 7.1e-29 99.7 0.1 1.3e-28 98.9 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination PP2C PF00481.21 EDN05880.1 - 8.3e-63 212.4 0.0 3.4e-51 174.3 0.0 3.2 2 1 0 2 2 2 2 Protein phosphatase 2C Snf7 PF03357.21 EDN05881.1 - 1.2e-34 119.4 18.7 1.1e-33 116.2 18.6 1.9 2 0 0 2 2 2 1 Snf7 Peptidase_M66 PF10462.9 EDN05881.1 - 0.041 12.8 0.2 0.061 12.3 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 Remorin_C PF03763.13 EDN05881.1 - 1.3 9.0 9.1 0.53 10.2 6.4 1.8 1 1 0 1 1 1 0 Remorin, C-terminal region YlqD PF11068.8 EDN05881.1 - 2.2 8.6 19.2 3.4 8.0 6.6 2.2 1 1 1 2 2 2 0 YlqD protein Mis14 PF08641.12 EDN05881.1 - 7.8 6.8 11.1 9.3 6.6 1.8 2.4 1 1 1 2 2 2 0 Kinetochore protein Mis14 like DUF2205 PF10224.9 EDN05882.1 - 0.0019 18.1 0.4 0.0065 16.4 0.3 1.9 2 0 0 2 2 2 1 Short coiled-coil protein SKA1 PF07160.12 EDN05882.1 - 0.052 13.4 6.0 2.1 8.2 0.1 3.1 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 MMR_HSR1 PF01926.23 EDN05882.1 - 0.076 13.1 0.1 0.97 9.5 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDN05882.1 - 0.32 11.0 2.2 1.1 9.3 0.0 2.7 3 0 0 3 3 3 0 Dynamin family PTCB-BRCT PF12738.7 EDN05883.1 - 1e-46 156.7 0.6 1.6e-24 85.7 0.1 3.4 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 EDN05883.1 - 6e-26 90.6 0.1 1.2e-10 41.6 0.0 4.1 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDN05883.1 - 6.7e-13 48.9 0.0 6.3e-06 26.5 0.0 4.4 4 0 0 4 4 4 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EDN05883.1 - 0.001 19.3 1.8 2.5 8.5 0.0 3.8 4 0 0 4 4 4 1 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EDN05883.1 - 0.014 15.2 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EDN05883.1 - 0.021 14.9 0.3 18 5.4 0.0 4.2 4 0 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain PIF1 PF05970.14 EDN05884.1 - 6.5e-62 209.8 0.6 7.5e-49 166.8 0.1 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EDN05884.1 - 1.8e-25 89.8 0.0 3.1e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN05884.1 - 1.6e-12 48.0 0.0 3.4e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDN05884.1 - 1.2e-07 32.1 0.0 3.4e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDN05884.1 - 1.5e-05 24.6 0.1 5.9e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region UvrD_C_2 PF13538.6 EDN05884.1 - 6.1e-05 22.8 0.2 0.001 18.9 0.1 2.5 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA PF00004.29 EDN05884.1 - 0.00018 21.9 0.1 0.00052 20.4 0.1 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Herpes_Helicase PF02689.14 EDN05884.1 - 0.00021 19.4 0.1 0.0011 17.1 0.0 2.0 2 0 0 2 2 2 1 Helicase AAA_16 PF13191.6 EDN05884.1 - 0.00062 20.2 0.0 0.0014 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EDN05884.1 - 0.0017 18.7 0.1 0.012 16.0 0.0 2.5 3 0 0 3 3 1 1 RNA helicase UvrD-helicase PF00580.21 EDN05884.1 - 0.0017 17.9 0.4 0.0039 16.8 0.1 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EDN05884.1 - 0.0032 17.0 0.1 0.03 13.8 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein NB-ARC PF00931.22 EDN05884.1 - 0.0041 16.3 0.0 0.0074 15.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain T2SSE PF00437.20 EDN05884.1 - 0.005 15.9 0.1 0.012 14.7 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 EDN05884.1 - 0.0056 16.4 0.8 2.7 7.7 0.2 3.4 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EDN05884.1 - 0.0063 16.6 0.2 0.035 14.1 0.2 2.2 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EDN05884.1 - 0.0091 16.0 1.0 0.04 13.9 0.4 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit NACHT PF05729.12 EDN05884.1 - 0.018 15.0 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF5605 PF18310.1 EDN05884.1 - 0.022 14.7 0.1 0.19 11.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5605) TrwB_AAD_bind PF10412.9 EDN05884.1 - 0.022 13.7 0.1 0.043 12.7 0.1 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Mg_chelatase PF01078.21 EDN05884.1 - 0.022 14.1 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 EDN05884.1 - 0.023 14.6 0.1 0.052 13.4 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF2075 PF09848.9 EDN05884.1 - 0.025 13.9 0.0 0.056 12.7 0.1 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EDN05884.1 - 0.027 14.4 0.9 0.091 12.7 0.9 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 EDN05884.1 - 0.062 13.0 0.1 0.38 10.5 0.1 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 EDN05884.1 - 0.079 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDN05884.1 - 0.082 13.4 0.2 0.27 11.7 0.2 2.1 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EDN05884.1 - 0.086 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein SH3_13 PF18335.1 EDN05884.1 - 0.088 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain AAA_11 PF13086.6 EDN05884.1 - 0.094 12.5 0.0 0.094 12.5 0.0 2.8 4 0 0 4 4 3 0 AAA domain AAA_5 PF07728.14 EDN05884.1 - 0.095 12.7 0.8 1.3 9.0 0.8 2.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EDN05884.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PI3_PI4_kinase PF00454.27 EDN05885.1 - 0.034 13.9 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase YjeF_N PF03853.15 EDN05886.1 - 1.3e-33 116.3 0.1 2.1e-33 115.6 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EDN05886.1 - 8.4e-08 33.0 4.8 2.9e-07 31.3 4.8 1.9 1 0 0 1 1 1 1 FDF domain NTP_transferase PF00483.23 EDN05886.1 - 0.091 12.3 0.0 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 Nucleotidyl transferase Pro_isomerase PF00160.21 EDN05887.1 - 6.4e-39 133.8 0.0 1.5e-38 132.5 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 EDN05887.1 - 0.00013 21.5 2.3 0.00031 20.2 2.3 1.7 1 1 0 1 1 1 1 Rtf2 RING-finger MGC-24 PF05283.11 EDN05887.1 - 1.8 9.0 4.6 4.2 7.8 4.6 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PUL PF08324.11 EDN05888.1 - 7.6e-58 195.9 0.0 1.1e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EDN05888.1 - 1.5e-34 119.0 0.0 2.6e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EDN05888.1 - 8.4e-16 57.8 0.0 1.4e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EDN05888.1 - 8.9e-07 29.0 0.0 1.5e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EDN05888.1 - 9.3e-05 22.8 0.2 0.00049 20.5 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 EDN05888.1 - 0.001 19.0 0.0 0.0028 17.7 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin domain OST3_OST6 PF04756.13 EDN05888.1 - 0.0026 17.2 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 EDN05888.1 - 0.061 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DIM1 PF02966.16 EDN05888.1 - 0.085 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 Redoxin PF08534.10 EDN05888.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Redoxin DUF2847 PF11009.8 EDN05888.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) EF-hand_9 PF14658.6 EDN05889.1 - 0.09 13.1 0.0 2.7 8.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain UCH PF00443.29 EDN05890.1 - 3.3e-07 30.1 0.2 9.2e-07 28.6 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3509 PF12021.8 EDN05890.1 - 0.18 11.5 1.5 0.48 10.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3509) Alb1 PF09135.11 EDN05891.1 - 1.8e-29 102.7 9.7 3.6e-29 101.7 9.7 1.5 1 0 0 1 1 1 1 Alb1 DUF2855 PF11017.8 EDN05891.1 - 0.012 15.4 0.9 0.018 14.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Vps16_N PF04841.13 EDN05892.1 - 5.8e-102 341.5 0.0 9.3e-102 340.8 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EDN05892.1 - 1.8e-68 230.9 0.1 2.8e-68 230.3 0.1 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EDN05892.1 - 1.6e-05 25.1 0.1 0.0082 16.4 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN05892.1 - 0.062 14.2 0.3 5 8.2 0.1 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF2428 PF10350.9 EDN05893.1 - 0.18 11.1 0.1 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 Putative death-receptor fusion protein (DUF2428) Bestrophin PF01062.21 EDN05895.1 - 4.4e-54 183.9 0.0 6.9e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF3246 PF11596.8 EDN05895.1 - 0.17 11.3 0.4 0.28 10.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) FHA PF00498.26 EDN05896.1 - 1.6e-13 50.8 0.0 2.7e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EDN05896.1 - 3.1e-10 39.6 4.2 6e-10 38.7 4.2 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EDN05896.1 - 2.6e-06 27.7 9.8 5.6e-06 26.6 9.8 1.6 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 EDN05896.1 - 6.6e-05 23.2 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 EDN05896.1 - 0.0037 17.2 7.8 0.0069 16.3 7.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EDN05896.1 - 0.018 15.0 1.8 0.039 14.0 1.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EDN05896.1 - 0.039 13.8 10.1 0.095 12.6 10.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EDN05896.1 - 0.042 14.2 6.7 0.089 13.1 6.7 1.6 1 0 0 1 1 1 0 RING-like domain zf-rbx1 PF12678.7 EDN05896.1 - 0.068 13.5 7.7 0.23 11.8 7.7 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDN05896.1 - 0.18 11.7 9.4 0.41 10.6 9.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3761 PF12587.8 EDN05896.1 - 0.29 11.6 0.0 0.29 11.6 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3761) PHD PF00628.29 EDN05896.1 - 0.52 10.2 6.5 1 9.3 6.5 1.5 1 0 0 1 1 1 0 PHD-finger DUF1610 PF07754.11 EDN05896.1 - 1.1 9.3 4.1 0.72 9.9 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) Zn_ribbon_17 PF17120.5 EDN05896.1 - 2.3 7.9 6.8 5 6.8 6.8 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type MDM10 PF12519.8 EDN05898.1 - 2.1e-146 488.4 0.4 1.8e-126 422.8 0.6 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 RL10P_insert PF17777.1 EDN05899.1 - 6.4e-23 80.5 0.0 1.2e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDN05899.1 - 7.2e-18 64.6 0.0 1.2e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 U1snRNP70_N PF12220.8 EDN05900.1 - 4.4e-29 101.0 2.2 7.3e-29 100.3 2.2 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EDN05900.1 - 2.8e-16 59.1 0.1 8.3e-16 57.6 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN05900.1 - 7.4e-06 26.0 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif L51_S25_CI-B8 PF05047.16 EDN05901.1 - 2e-15 56.5 0.1 2.9e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain zf-RING_5 PF14634.6 EDN05902.1 - 0.0055 16.6 2.9 0.012 15.6 2.9 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDN05902.1 - 0.0063 16.5 1.9 0.012 15.6 1.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDN05902.1 - 0.017 15.4 1.9 0.017 15.4 1.9 1.8 2 1 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 EDN05902.1 - 0.021 14.7 1.6 0.028 14.2 0.2 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDN05902.1 - 0.25 11.2 4.4 3.1 7.7 4.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDN05902.1 - 0.27 11.1 5.1 4.4 7.3 6.2 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 EDN05902.1 - 0.41 10.9 6.0 2.2 8.6 2.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 EDN05902.1 - 0.42 10.5 7.6 0.14 12.0 4.0 2.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EDN05902.1 - 0.45 10.7 3.6 0.83 9.8 3.6 1.5 1 1 0 1 1 1 0 FYVE zinc finger Prp19 PF08606.11 EDN05903.1 - 1.2e-32 111.7 1.8 1.2e-32 111.7 1.8 1.8 2 0 0 2 2 2 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EDN05903.1 - 8.6e-15 54.8 0.8 6e-06 26.5 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN05903.1 - 3.9e-14 52.8 4.8 1.2e-05 26.0 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.11 EDN05903.1 - 3.5e-07 30.3 0.4 0.13 12.1 0.0 3.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDN05903.1 - 1.8e-06 27.5 0.2 3.9e-05 23.1 0.1 2.3 2 1 1 3 3 3 1 WD40-like domain V_ATPase_I_N PF18670.1 EDN05903.1 - 0.00054 20.3 0.2 0.0011 19.3 0.2 1.5 1 0 0 1 1 1 1 V-type ATPase subunit I, N-terminal domain Ge1_WD40 PF16529.5 EDN05903.1 - 0.0053 15.8 0.6 0.011 14.8 0.1 1.8 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Mcl1_mid PF12341.8 EDN05903.1 - 0.018 14.4 0.0 0.048 13.0 0.0 1.7 1 1 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region zf-Nse PF11789.8 EDN05903.1 - 0.027 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Lactonase PF10282.9 EDN05903.1 - 0.044 13.0 0.0 0.096 11.9 0.0 1.6 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Frtz PF11768.8 EDN05903.1 - 0.089 11.1 0.0 0.15 10.4 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF4604 PF15377.6 EDN05904.1 - 3.5e-15 56.9 7.3 3.8e-15 56.7 7.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) GTP_EFTU PF00009.27 EDN05905.1 - 1.5e-41 142.1 0.1 5.2e-41 140.3 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDN05905.1 - 9.6e-09 35.5 0.0 2.9e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDN05905.1 - 1.2e-06 28.5 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EDN05905.1 - 0.0021 17.8 0.0 0.01 15.6 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV Gluconate_2-dh3 PF13618.6 EDN05905.1 - 0.014 15.6 0.2 1.2 9.4 0.0 3.2 2 1 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 CHASE2 PF05226.11 EDN05905.1 - 0.025 14.3 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 CHASE2 domain D123 PF07065.14 EDN05905.1 - 0.063 12.4 0.7 0.17 11.0 0.7 1.6 1 0 0 1 1 1 0 D123 EXOSC1 PF10447.9 EDN05906.1 - 3.4e-30 104.9 0.3 6.7e-30 103.9 0.3 1.5 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EDN05906.1 - 1.3e-12 47.3 0.2 2.5e-12 46.4 0.2 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region Arm PF00514.23 EDN05907.1 - 6.4e-54 178.5 21.3 3.4e-12 46.0 0.2 9.1 9 1 1 10 10 10 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDN05907.1 - 6.2e-19 68.1 13.0 3.7e-06 27.3 0.3 6.4 4 1 3 7 7 7 5 HEAT-like repeat HEAT PF02985.22 EDN05907.1 - 1.7e-15 55.8 9.4 0.15 12.4 0.0 7.5 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 EDN05907.1 - 8.4e-15 54.9 6.1 0.00023 21.5 0.1 6.0 4 2 2 6 6 6 4 HEAT repeats Adaptin_N PF01602.20 EDN05907.1 - 5.5e-10 38.4 7.9 2.5e-08 33.0 0.9 2.8 2 1 1 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.13 EDN05907.1 - 7.9e-07 28.8 4.4 1.6e-06 27.8 3.7 1.8 1 1 1 2 2 2 1 Armadillo-like V-ATPase_H_N PF03224.14 EDN05907.1 - 1.5e-05 24.4 2.4 0.00027 20.3 2.1 2.4 2 1 0 2 2 2 1 V-ATPase subunit H KAP PF05804.12 EDN05907.1 - 2.2e-05 22.9 1.5 3.9e-05 22.0 1.0 1.5 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) Cnd1 PF12717.7 EDN05907.1 - 0.00021 21.4 5.0 0.024 14.7 1.1 4.1 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 DUF5578 PF17741.1 EDN05907.1 - 0.0024 17.3 6.8 0.12 11.7 0.0 4.0 2 1 3 5 5 5 1 Family of unknown function (DUF5578) DUF3361 PF11841.8 EDN05907.1 - 0.0056 16.6 5.7 1.8 8.5 1.1 3.1 1 1 2 3 3 3 2 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 EDN05907.1 - 0.026 14.6 4.8 4.8 7.3 0.7 3.9 2 1 3 5 5 5 0 V-ATPase subunit H HEAT_PBS PF03130.16 EDN05907.1 - 0.03 15.0 5.2 1.1e+02 3.9 0.0 6.3 7 0 0 7 7 6 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDN05907.1 - 0.039 14.5 0.3 1.2 9.8 0.1 3.0 1 1 3 4 4 4 0 Vacuolar 14 Fab1-binding region Atx10homo_assoc PF09759.9 EDN05907.1 - 0.29 11.2 2.3 5.1 7.2 0.3 3.3 3 1 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain TIM PF00121.18 EDN05908.1 - 9e-30 103.8 0.0 9.7e-30 103.7 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase FAM92 PF06730.11 EDN05910.1 - 0.0044 16.5 3.8 0.0062 16.0 3.8 1.2 1 0 0 1 1 1 1 FAM92 protein Pkinase PF00069.25 EDN05911.1 - 3.9e-05 23.1 0.0 6.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN05911.1 - 5.1e-05 22.7 0.0 8.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN05911.1 - 0.00019 21.4 0.0 0.00036 20.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN05911.1 - 0.0068 16.0 0.1 0.02 14.5 0.1 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EDN05911.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kinesin PF00225.23 EDN05912.1 - 1.3e-114 382.6 0.0 2.4e-114 381.7 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDN05912.1 - 9.8e-25 87.2 1.1 1.3e-24 86.8 0.1 1.7 2 0 0 2 2 2 1 Microtubule binding Spc7 PF08317.11 EDN05912.1 - 0.058 12.3 8.6 0.091 11.6 8.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DAPDH_C PF16654.5 EDN05912.1 - 0.26 11.1 1.8 0.67 9.8 1.5 1.8 1 1 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain DUF87 PF01935.17 EDN05912.1 - 0.74 9.9 0.0 0.74 9.9 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain IF-2B PF01008.17 EDN05913.1 - 2.2e-76 256.8 0.1 2.9e-76 256.4 0.1 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ndc1_Nup PF09531.10 EDN05913.1 - 0.86 8.2 3.2 1.2 7.7 3.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SARAF PF06682.12 EDN05913.1 - 1.4 8.5 12.7 2.7 7.6 12.7 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Hamartin PF04388.12 EDN05913.1 - 2.5 6.7 6.9 3.6 6.1 6.9 1.2 1 0 0 1 1 1 0 Hamartin protein API5 PF05918.11 EDN05913.1 - 7.4 5.2 8.5 11 4.7 8.5 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Apc13p PF05839.11 EDN05914.1 - 6e-20 71.2 1.2 2.2e-17 63.0 0.0 2.2 2 1 0 2 2 2 2 Apc13p protein Pol_alpha_B_N PF08418.10 EDN05915.1 - 1.9e-64 218.0 0.0 3e-64 217.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EDN05915.1 - 9.7e-33 113.3 0.0 1.4e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B CRAL_TRIO PF00650.20 EDN05916.1 - 1.1e-35 122.8 0.0 1.4e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDN05916.1 - 1.6e-13 50.6 0.0 2.9e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDN05916.1 - 0.00024 21.3 0.0 0.00035 20.8 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CBS PF00571.28 EDN05917.1 - 4.5e-24 84.7 7.4 2.2e-11 44.0 0.2 4.3 4 0 0 4 4 4 4 CBS domain ECH_2 PF16113.5 EDN05921.1 - 1.1e-25 90.9 0.0 2.1e-25 90.0 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EDN05921.1 - 1.1e-06 28.2 0.0 2.7e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Ribosomal_L4 PF00573.22 EDN05922.1 - 2.2e-21 76.4 0.0 2.7e-21 76.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family PBP PF01161.20 EDN05923.1 - 4.9e-10 39.8 0.0 6.9e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Peptidase_S24 PF00717.23 EDN05924.1 - 5.8e-07 29.4 0.0 8.1e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like Auto_anti-p27 PF06677.12 EDN05924.1 - 0.13 12.5 0.1 0.43 10.8 0.0 1.8 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CDC45 PF02724.14 EDN05926.1 - 5.5 5.2 6.4 7.2 4.8 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Lactamase_B PF00753.27 EDN05927.1 - 1.4e-08 35.0 0.5 5.6e-07 29.8 0.3 2.3 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily HAGH_C PF16123.5 EDN05927.1 - 3.7e-05 24.1 0.2 6.7e-05 23.3 0.2 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus BcrAD_BadFG PF01869.20 EDN05927.1 - 0.0096 15.4 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Lactamase_B_2 PF12706.7 EDN05927.1 - 0.12 11.9 0.2 0.39 10.2 0.2 1.9 1 1 0 1 1 1 0 Beta-lactamase superfamily domain DDE_3 PF13358.6 EDN05928.1 - 0.00014 21.7 0.4 0.00021 21.1 0.1 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 EDN05929.1 - 5.3e-27 93.9 0.1 9.3e-27 93.1 0.1 1.4 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EDN05929.1 - 1.3e-05 25.7 0.2 4.6e-05 23.9 0.0 2.0 3 0 0 3 3 3 1 Homeodomain-like domain HTH_33 PF13592.6 EDN05929.1 - 0.0067 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_21 PF13276.6 EDN05929.1 - 0.0069 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 HTH-like domain HTH_23 PF13384.6 EDN05929.1 - 0.05 13.4 0.0 4.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HTH_10 PF04967.12 EDN05929.1 - 0.07 13.0 0.0 6.3 6.7 0.0 2.6 2 1 0 2 2 2 0 HTH DNA binding domain EspA PF03433.13 EDN05929.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 EspA-like secreted protein YL1 PF05764.13 EDN05930.1 - 1.5e-05 25.3 26.7 2e-05 24.9 26.7 1.2 1 0 0 1 1 1 1 YL1 nuclear protein RR_TM4-6 PF06459.12 EDN05930.1 - 4.1e-05 23.6 19.6 5.2e-05 23.2 19.6 1.3 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EDN05930.1 - 0.00012 21.0 8.2 0.00015 20.7 8.2 1.2 1 0 0 1 1 1 1 Presenilin FGF-BP1 PF06473.12 EDN05930.1 - 0.00018 21.5 22.8 0.00022 21.1 22.8 1.1 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) LAP1C PF05609.12 EDN05930.1 - 0.00021 20.5 7.8 0.00024 20.3 7.8 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 EDN05930.1 - 0.00034 19.0 18.6 0.0004 18.8 18.6 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF2207 PF09972.9 EDN05930.1 - 0.00093 18.1 9.4 0.0011 17.8 9.4 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Zip PF02535.22 EDN05930.1 - 0.0013 18.0 8.0 0.0017 17.6 8.0 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DDHD PF02862.17 EDN05930.1 - 0.0015 18.7 5.5 0.0019 18.4 5.5 1.4 1 0 0 1 1 1 1 DDHD domain Serinc PF03348.15 EDN05930.1 - 0.0016 17.4 2.9 0.0022 17.0 2.9 1.3 1 0 0 1 1 1 1 Serine incorporator (Serinc) RPOL_N PF14700.6 EDN05930.1 - 0.0022 17.4 14.8 0.0025 17.3 14.8 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal DUF2151 PF10221.9 EDN05930.1 - 0.0025 16.5 12.0 0.0025 16.5 12.0 1.0 1 0 0 1 1 1 1 Cell cycle and development regulator DAG_kinase_N PF14513.6 EDN05930.1 - 0.0026 18.0 13.2 0.0033 17.6 13.2 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus Ctr PF04145.15 EDN05930.1 - 0.0027 18.3 0.3 0.004 17.8 0.3 1.3 1 0 0 1 1 1 1 Ctr copper transporter family VIT1 PF01988.19 EDN05930.1 - 0.0036 17.2 0.0 0.0048 16.8 0.0 1.1 1 0 0 1 1 1 1 VIT family NPR3 PF03666.13 EDN05930.1 - 0.0036 16.2 21.5 0.0044 15.9 21.5 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 EDN05930.1 - 0.0038 16.3 7.9 0.0042 16.1 7.9 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) DUF2370 PF10176.9 EDN05930.1 - 0.0041 16.8 1.7 0.0046 16.6 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) DUF4228 PF14009.6 EDN05930.1 - 0.005 17.3 5.3 0.0056 17.1 5.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4228) HCO3_cotransp PF00955.21 EDN05930.1 - 0.0053 15.6 2.9 0.0062 15.4 2.9 1.1 1 0 0 1 1 1 1 HCO3- transporter family V_ATPase_I PF01496.19 EDN05930.1 - 0.0056 14.7 16.0 0.0068 14.4 16.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Kei1 PF08552.11 EDN05930.1 - 0.0072 16.2 1.3 0.0099 15.8 1.3 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 CSG2 PF16965.5 EDN05930.1 - 0.0089 15.0 5.9 0.01 14.8 5.9 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator DUF5308 PF17233.2 EDN05930.1 - 0.009 16.3 1.4 0.013 15.7 1.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5308) DUF2828 PF11443.8 EDN05930.1 - 0.0091 14.1 20.3 0.011 13.9 20.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Orf78 PF06024.12 EDN05930.1 - 0.011 16.1 4.0 0.011 16.1 4.0 2.2 1 1 1 2 2 2 0 Orf78 (ac78) Rrn6 PF10214.9 EDN05930.1 - 0.012 14.2 7.1 0.013 14.0 7.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor RP-C_C PF11800.8 EDN05930.1 - 0.013 15.7 4.0 0.013 15.6 4.0 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Scs3p PF10261.9 EDN05930.1 - 0.013 15.0 0.9 0.017 14.7 0.9 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM CLN3 PF02487.17 EDN05930.1 - 0.016 14.3 9.0 0.018 14.1 9.0 1.1 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 EDN05930.1 - 0.022 14.3 28.0 0.032 13.8 28.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 LicD PF04991.13 EDN05930.1 - 0.024 14.8 20.0 0.027 14.6 20.0 1.1 1 0 0 1 1 1 0 LicD family Band_3_cyto PF07565.13 EDN05930.1 - 0.026 14.3 7.6 0.029 14.2 7.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RNA_pol_Rpc4 PF05132.14 EDN05930.1 - 0.026 15.0 22.2 0.05 14.0 22.2 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 NARP1 PF12569.8 EDN05930.1 - 0.029 13.3 33.3 0.041 12.8 33.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Endostatin PF06482.11 EDN05930.1 - 0.036 13.5 9.7 0.044 13.2 9.7 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MDM10 PF12519.8 EDN05930.1 - 0.042 12.7 13.7 0.048 12.5 13.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Vfa1 PF08432.10 EDN05930.1 - 0.047 14.0 37.8 0.069 13.5 37.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SAPS PF04499.15 EDN05930.1 - 0.047 12.5 11.1 0.053 12.3 11.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ni_hydr_CYTB PF01292.20 EDN05930.1 - 0.047 13.3 0.0 0.066 12.8 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Rtf2 PF04641.12 EDN05930.1 - 0.057 12.8 35.3 0.075 12.4 35.3 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger ABC2_membrane_3 PF12698.7 EDN05930.1 - 0.063 12.4 0.0 0.071 12.2 0.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein SOBP PF15279.6 EDN05930.1 - 0.067 13.8 9.1 0.072 13.7 9.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2052 PF09747.9 EDN05930.1 - 0.074 13.2 18.6 0.094 12.8 18.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Neur_chan_memb PF02932.16 EDN05930.1 - 0.081 13.0 9.7 0.097 12.7 9.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4820 PF16091.5 EDN05930.1 - 0.089 12.2 17.7 4.6 6.5 4.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) DUF2427 PF10348.9 EDN05930.1 - 0.097 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Dsh_C PF12316.8 EDN05930.1 - 0.12 12.8 1.9 0.15 12.5 1.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SLC12 PF03522.15 EDN05930.1 - 0.17 10.8 21.7 0.2 10.6 21.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF262 PF03235.14 EDN05930.1 - 0.17 12.0 14.1 0.21 11.8 14.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 SpoIIP PF07454.11 EDN05930.1 - 0.24 10.8 24.2 0.32 10.4 24.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pkinase_fungal PF17667.1 EDN05930.1 - 0.27 10.0 12.3 0.32 9.7 12.3 1.1 1 0 0 1 1 1 0 Fungal protein kinase MCM_bind PF09739.9 EDN05930.1 - 0.28 9.6 19.9 0.34 9.3 19.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Otopetrin PF03189.13 EDN05930.1 - 0.34 9.7 6.5 0.49 9.2 6.5 1.3 1 0 0 1 1 1 0 Otopetrin Membralin PF09746.9 EDN05930.1 - 0.35 9.9 10.8 0.4 9.7 10.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein SID-1_RNA_chan PF13965.6 EDN05930.1 - 0.37 9.2 9.7 0.43 8.9 9.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FancD2 PF14631.6 EDN05930.1 - 0.41 8.0 18.5 0.48 7.8 18.5 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease ALMT PF11744.8 EDN05930.1 - 0.43 9.4 15.6 0.5 9.1 15.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2126 PF09899.9 EDN05930.1 - 0.45 8.5 8.3 0.55 8.2 8.3 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) GAGA_bind PF06217.12 EDN05930.1 - 0.47 10.7 28.3 0.7 10.1 28.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Gti1_Pac2 PF09729.9 EDN05930.1 - 0.47 10.5 22.2 0.67 10.0 22.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family PTR2 PF00854.21 EDN05930.1 - 0.53 9.1 3.9 0.64 8.8 3.9 1.2 1 0 0 1 1 1 0 POT family BORG_CEP PF14957.6 EDN05930.1 - 0.63 11.2 13.9 0.88 10.7 13.9 1.2 1 0 0 1 1 1 0 Cdc42 effector AAA_11 PF13086.6 EDN05930.1 - 0.73 9.6 21.5 0.86 9.3 21.5 1.1 1 0 0 1 1 1 0 AAA domain Ureide_permease PF07168.11 EDN05930.1 - 0.74 8.5 11.3 0.97 8.1 11.3 1.2 1 0 0 1 1 1 0 Ureide permease MMM1 PF10296.9 EDN05930.1 - 0.85 8.6 11.2 1.2 8.2 11.2 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 SRP-alpha_N PF04086.13 EDN05930.1 - 0.9 9.4 31.6 1.4 8.7 31.6 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 EDN05930.1 - 0.9 8.1 7.5 1 8.0 7.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PIG-U PF06728.13 EDN05930.1 - 0.91 8.5 4.4 4.8 6.1 4.4 1.9 1 1 0 1 1 1 0 GPI transamidase subunit PIG-U DUF3112 PF11309.8 EDN05930.1 - 0.98 8.8 3.1 0.62 9.5 1.5 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF3112) YABBY PF04690.13 EDN05930.1 - 1 9.9 14.6 1.7 9.2 14.6 1.4 1 0 0 1 1 1 0 YABBY protein Cellulose_synt PF03552.14 EDN05930.1 - 1.1 7.7 11.8 1.3 7.5 11.8 1.1 1 0 0 1 1 1 0 Cellulose synthase TraU PF06834.11 EDN05930.1 - 1.1 8.4 3.3 12 5.0 3.3 2.0 1 1 0 1 1 1 0 TraU protein VIR_N PF15912.5 EDN05930.1 - 1.2 8.7 15.5 1.5 8.4 15.5 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Mem_trans PF03547.18 EDN05930.1 - 1.2 7.4 5.3 1.5 7.2 5.3 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF4776 PF16003.5 EDN05930.1 - 1.3 8.0 30.2 1.5 7.7 30.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Hydin_ADK PF17213.3 EDN05930.1 - 1.4 9.1 7.4 2 8.7 7.4 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain AAA_23 PF13476.6 EDN05930.1 - 1.5 9.3 29.8 2.1 8.8 29.8 1.2 1 0 0 1 1 1 0 AAA domain Pannexin_like PF12534.8 EDN05930.1 - 1.6 7.8 12.6 2.1 7.4 12.6 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 ASC PF00858.24 EDN05930.1 - 1.7 7.5 12.6 2.1 7.2 12.6 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Mpp10 PF04006.12 EDN05930.1 - 1.8 6.9 41.8 2.3 6.5 41.8 1.1 1 0 0 1 1 1 0 Mpp10 protein Mitofilin PF09731.9 EDN05930.1 - 2 7.2 27.7 2.4 6.9 27.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF789 PF05623.12 EDN05930.1 - 2.1 8.0 13.2 2.7 7.6 13.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) PA26 PF04636.13 EDN05930.1 - 3.8 6.3 12.9 4.4 6.1 12.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Smg8_Smg9 PF10220.9 EDN05930.1 - 4.2 5.5 17.7 5.3 5.2 17.7 1.0 1 0 0 1 1 1 0 Smg8_Smg9 eIF3_subunit PF08597.10 EDN05930.1 - 4.4 7.2 47.5 8.2 6.3 47.5 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit CAC1F_C PF16885.5 EDN05930.1 - 5 6.7 10.8 5.8 6.5 10.8 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LMBR1 PF04791.16 EDN05930.1 - 5.5 5.8 9.9 8.2 5.2 9.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4569 PF15133.6 EDN05930.1 - 6.3 6.4 18.7 8.3 6.0 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Connexin PF00029.19 EDN05930.1 - 6.4 6.5 29.2 13 5.5 29.2 1.7 1 1 0 1 1 1 0 Connexin FliP PF00813.20 EDN05930.1 - 7.9 6.3 8.7 15 5.4 8.8 1.5 1 1 0 1 1 1 0 FliP family XRN_M PF17846.1 EDN05930.1 - 8.8 5.2 19.8 11 4.8 19.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain IHABP4_N PF16174.5 EDN05930.1 - 9.1 6.9 38.7 14 6.2 38.7 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Myb_DNA-binding PF00249.31 EDN05931.1 - 1.3e-14 54.1 2.2 7.5e-11 42.1 0.1 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN05931.1 - 3.2e-07 30.5 0.3 0.00029 21.0 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Pkinase PF00069.25 EDN05932.1 - 2.5e-08 33.6 0.0 5.5e-08 32.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN05932.1 - 2.3e-07 31.0 0.2 2.1e-06 27.9 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN05932.1 - 0.00036 19.9 0.0 0.00065 19.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EDN05932.1 - 0.0095 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HSDR_N_2 PF13588.6 EDN05932.1 - 0.012 15.6 0.0 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Choline_kinase PF01633.20 EDN05932.1 - 0.095 12.3 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EDN05933.1 - 0.00066 19.1 0.3 0.0014 18.0 0.3 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN05933.1 - 0.015 14.9 0.1 0.045 13.3 0.0 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 EDN05933.1 - 0.025 14.2 0.0 0.056 13.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Rootletin PF15035.6 EDN05933.1 - 0.048 13.7 17.1 0.13 12.3 17.1 1.8 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion APH PF01636.23 EDN05933.1 - 0.091 12.7 0.3 0.091 12.7 0.3 3.2 2 1 0 3 3 3 0 Phosphotransferase enzyme family SurA_N_2 PF13623.6 EDN05933.1 - 1.6 8.6 5.6 2.6 7.9 4.0 2.1 1 1 1 2 2 2 0 SurA N-terminal domain SurA_N_3 PF13624.6 EDN05933.1 - 6.4 6.6 7.5 11 5.8 6.4 2.0 2 1 0 2 2 2 0 SurA N-terminal domain BCS1_N PF08740.11 EDN05935.1 - 5.1e-36 124.4 0.1 7.9e-36 123.8 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN05935.1 - 5.4e-20 72.2 0.0 3e-19 69.7 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN05935.1 - 6e-06 26.8 0.1 1.9e-05 25.1 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EDN05935.1 - 0.019 15.1 0.0 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EDN05935.1 - 0.039 12.8 0.0 0.069 12.0 0.0 1.4 1 0 0 1 1 1 0 Papillomavirus helicase AAA_25 PF13481.6 EDN05935.1 - 0.057 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN05935.1 - 0.059 13.4 0.0 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EDN05935.1 - 0.064 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EDN05935.1 - 0.071 13.7 0.0 1.4 9.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN05935.1 - 0.075 12.8 0.0 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EDN05935.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EDN05935.1 - 0.14 11.3 0.0 0.95 8.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF815) DUF3435 PF11917.8 EDN05938.1 - 6e-162 539.3 0.2 7.9e-162 538.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DDE_Tnp_ISL3 PF01610.17 EDN05938.1 - 0.012 15.3 1.4 0.12 12.1 0.5 2.2 2 0 0 2 2 2 0 Transposase zf-C2H2_4 PF13894.6 EDN05938.1 - 0.88 10.6 5.6 4.7 8.3 0.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Toxin_20 PF08089.11 EDN05938.1 - 5.3 7.2 7.2 0.16 12.1 0.8 1.7 2 0 0 2 2 2 0 Huwentoxin-II family AAA PF00004.29 EDN05939.1 - 3.8e-07 30.6 0.0 5.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NAD_kinase PF01513.21 EDN05942.1 - 4.5e-65 219.7 0.0 6.2e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EDN05942.1 - 0.079 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain TRAPP PF04051.16 EDN05943.1 - 1.3e-38 132.0 0.0 1.9e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component MFAP1 PF06991.11 EDN05944.1 - 1.2e-42 146.2 20.5 1.2e-42 146.2 20.5 2.4 2 1 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing HNH_2 PF13391.6 EDN05945.1 - 6.4e-10 39.0 0.4 4.9e-09 36.2 0.0 2.6 2 0 0 2 2 2 1 HNH endonuclease Glyco_hydro_16 PF00722.21 EDN05946.1 - 6.4e-46 156.0 2.9 9.9e-46 155.4 2.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Amidase_2 PF01510.25 EDN05947.1 - 8.9e-05 23.0 0.7 0.00017 22.0 0.7 1.4 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Rep_fac-A_3 PF08661.11 EDN05948.1 - 2.4e-22 79.2 0.0 2.9e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 Ten1 PF12658.7 EDN05948.1 - 0.013 15.4 0.1 0.29 11.1 0.1 2.0 1 1 0 1 1 1 0 Telomere capping, CST complex subunit SepZ PF06066.11 EDN05948.1 - 0.06 13.6 0.2 0.092 13.0 0.2 1.3 1 0 0 1 1 1 0 SepZ GATA PF00320.27 EDN05949.1 - 2.7e-05 23.7 4.7 0.0021 17.6 0.8 2.8 2 0 0 2 2 2 2 GATA zinc finger zf-RING_7 PF02591.15 EDN05949.1 - 0.07 13.3 0.9 0.15 12.2 0.9 1.6 1 0 0 1 1 1 0 C4-type zinc ribbon domain LSM PF01423.22 EDN05950.1 - 1.1e-18 66.6 0.1 1.5e-18 66.3 0.1 1.2 1 0 0 1 1 1 1 LSM domain Dak1 PF02733.17 EDN05952.1 - 2e-56 191.2 0.5 2.9e-56 190.6 0.5 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EDN05952.1 - 1.5e-44 151.9 0.1 2.3e-44 151.4 0.1 1.3 1 0 0 1 1 1 1 DAK2 domain Fiji_64_capsid PF05880.11 EDN05952.1 - 0.095 11.3 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 Fijivirus 64 kDa capsid protein Nup192 PF11894.8 EDN05953.1 - 0 1122.5 9.8 5.5e-301 1001.8 7.0 2.1 1 1 1 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 Cullin PF00888.22 EDN05953.1 - 3e-149 498.5 4.9 1.4e-132 443.5 3.5 3.6 2 1 2 4 4 4 3 Cullin family Cullin_Nedd8 PF10557.9 EDN05953.1 - 2e-22 79.0 0.4 5e-22 77.7 0.4 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain DCB PF16213.5 EDN05953.1 - 0.42 10.3 3.2 0.31 10.7 0.2 2.4 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 PI3_PI4_kinase PF00454.27 EDN05954.1 - 2.4e-54 184.8 0.8 3.3e-53 181.0 0.0 2.4 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EDN05954.1 - 1.9e-09 37.2 1.1 3.3e-08 33.2 0.1 2.5 2 0 0 2 2 2 1 FATC domain FAT PF02259.23 EDN05954.1 - 2.1e-05 23.9 3.7 3.4e-05 23.2 3.7 1.3 1 0 0 1 1 1 1 FAT domain TPR_14 PF13428.6 EDN05954.1 - 0.12 13.3 0.0 0.54 11.2 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat SUKH-4 PF14435.6 EDN05954.1 - 0.12 12.4 0.0 0.42 10.7 0.0 1.9 2 0 0 2 2 2 0 SUKH-4 immunity protein zf-C3HC4_2 PF13923.6 EDN05955.1 - 1.3e-07 31.3 10.8 5.1e-07 29.4 7.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN05955.1 - 1.7e-07 31.0 7.1 1e-06 28.5 7.7 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN05955.1 - 2e-07 30.9 9.3 2.7e-06 27.3 5.7 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDN05955.1 - 3.2e-06 27.4 11.6 6.7e-06 26.3 11.6 1.6 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN05955.1 - 4.6e-06 26.4 11.8 1.5e-05 24.7 11.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDN05955.1 - 1.3e-05 25.0 9.9 2.4e-05 24.2 9.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDN05955.1 - 7.8e-05 22.7 4.5 7.8e-05 22.7 4.5 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EDN05955.1 - 0.032 14.1 3.0 0.059 13.2 3.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EDN05955.1 - 0.074 12.9 13.9 3.2 7.7 14.3 2.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EDN05955.1 - 0.61 9.9 8.0 2.5 8.0 8.1 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Baculo_IE-1 PF05290.11 EDN05955.1 - 0.75 9.7 4.2 1.5 8.7 4.1 1.5 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Rad50_zn_hook PF04423.14 EDN05955.1 - 1.2 9.0 5.4 1 9.3 0.2 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-rbx1 PF12678.7 EDN05955.1 - 2.4 8.5 10.9 8.4 6.8 10.9 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDN05955.1 - 3.1 7.9 7.9 17 5.5 7.9 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EDN05955.1 - 7.9 6.4 8.6 5.6 6.9 5.7 2.2 2 1 0 2 2 2 0 zf-RING of BARD1-type protein DNApol_Exo PF18136.1 EDN05956.1 - 2e-104 348.7 0.0 3.3e-104 348.0 0.0 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EDN05956.1 - 1.9e-57 195.0 0.0 3.3e-57 194.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A DUF1365 PF07103.11 EDN05956.1 - 0.0041 16.8 0.0 0.0077 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) DNA_pol_A_exo1 PF01612.20 EDN05956.1 - 0.15 11.7 0.1 1.8 8.2 0.1 2.4 1 1 0 1 1 1 0 3'-5' exonuclease CorA PF01544.18 EDN05957.1 - 7.6e-16 58.3 5.0 1.2e-09 37.9 0.0 3.5 4 0 0 4 4 4 3 CorA-like Mg2+ transporter protein SQS_PSY PF00494.19 EDN05958.1 - 2.3e-49 168.3 0.0 3.7e-49 167.6 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase SNF2_N PF00176.23 EDN05959.1 - 3.4e-69 233.2 0.0 4.5e-69 232.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EDN05959.1 - 2e-18 66.1 0.0 4.1e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain ResIII PF04851.15 EDN05959.1 - 4.8e-05 23.4 0.0 0.0001 22.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EDN05959.1 - 0.00017 21.4 5.6 0.00037 20.3 5.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN05959.1 - 0.00024 20.9 6.3 0.00047 20.0 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN05959.1 - 0.00024 20.9 7.6 0.00048 19.9 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN05959.1 - 0.0003 20.7 7.6 0.00062 19.7 7.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Helicase_C PF00271.31 EDN05959.1 - 0.00038 20.8 0.0 0.001 19.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 EDN05959.1 - 0.00057 20.2 8.1 0.0013 19.0 8.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDN05959.1 - 0.0071 16.3 6.8 0.016 15.2 6.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain PLU-1 PF08429.11 EDN05959.1 - 0.015 14.5 0.5 0.03 13.5 0.5 1.4 1 0 0 1 1 1 0 PLU-1-like protein zf-C3HC4_4 PF15227.6 EDN05959.1 - 0.053 13.7 7.0 0.1 12.7 7.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EDN05959.1 - 2.3 8.1 7.0 9.9 6.1 7.3 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 GTP_EFTU PF00009.27 EDN05960.1 - 1.9e-19 70.0 0.0 5.3e-19 68.5 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDN05960.1 - 2.5e-09 37.4 2.2 1.4e-08 35.0 1.1 2.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EDN05960.1 - 1.4e-05 25.4 0.0 3.5e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EDN05960.1 - 0.0021 18.1 0.1 0.0082 16.2 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EDN05960.1 - 0.0079 15.9 0.3 2.3 8.0 0.1 3.3 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EDN05960.1 - 0.035 14.0 0.1 5.5 6.9 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase Roc PF08477.13 EDN05960.1 - 0.095 12.9 0.3 1.4 9.2 0.1 2.7 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EDN05960.1 - 0.11 12.5 0.5 0.37 10.8 0.1 2.0 2 0 0 2 2 2 0 Dynamin family LSM PF01423.22 EDN05961.1 - 1.5e-18 66.2 0.2 1.9e-18 65.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain ATP13 PF12921.7 EDN05962.1 - 1.1e-29 102.6 0.0 1.9e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_3 PF13812.6 EDN05962.1 - 0.00094 19.2 0.0 4.5 7.4 0.0 3.3 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 EDN05962.1 - 0.0021 18.2 0.0 0.007 16.5 0.0 1.9 1 0 0 1 1 1 1 PPR repeat family Cys_Met_Meta_PP PF01053.20 EDN05962.1 - 0.14 10.7 0.0 0.23 10.0 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme PIG-L PF02585.17 EDN05963.1 - 6.6e-28 98.0 0.0 8.8e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase LDB19 PF13002.7 EDN05964.1 - 2.2e-64 216.7 0.1 3.5e-64 216.1 0.1 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EDN05964.1 - 1.4e-05 25.2 0.0 3.2e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF4606 PF15379.6 EDN05964.1 - 0.079 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) MFS_1 PF07690.16 EDN05966.1 - 1.9e-25 89.6 24.5 1.9e-25 89.6 24.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily p450 PF00067.22 EDN05967.1 - 6.1e-22 78.0 0.0 6e-16 58.2 0.0 3.0 1 1 2 3 3 3 3 Cytochrome P450 TPP_enzyme_N PF02776.18 EDN05968.1 - 3.3e-32 111.5 0.0 7.8e-32 110.2 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDN05968.1 - 1.4e-17 63.7 0.0 3.8e-17 62.3 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDN05968.1 - 9.1e-15 54.8 0.0 2.4e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 EDN05968.1 - 0.081 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EDN05968.1 - 0.09 12.0 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase ORF_12_N PF18042.1 EDN05971.1 - 0.0084 16.5 0.6 0.054 13.9 0.3 2.2 2 0 0 2 2 2 1 ORF 12 gene product N-terminal RNase_H PF00075.24 EDN05972.1 - 4e-11 43.3 0.1 2.4e-10 40.7 0.1 2.0 1 1 0 1 1 1 1 RNase H DIOX_N PF14226.6 EDN05973.1 - 1.8e-28 99.6 0.0 2.8e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EDN05973.1 - 1.5e-17 63.9 0.0 2.5e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DnaJ PF00226.31 EDN05974.1 - 7.8e-20 70.8 1.8 9.7e-20 70.5 0.4 2.0 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 EDN05974.1 - 0.093 12.6 0.3 0.3 10.9 0.3 1.9 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Big_4 PF07532.11 EDN05975.1 - 0.0096 15.6 0.2 0.016 14.9 0.2 1.4 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 4) phiKZ_IP PF12699.7 EDN05975.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins HTH_8 PF02954.19 EDN05976.1 - 0.01 15.6 1.6 0.12 12.2 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory protein, Fis family HTH_Tnp_Tc5 PF03221.16 EDN05976.1 - 0.04 13.9 0.2 0.19 11.8 0.0 2.3 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF4322 PF14210.6 EDN05976.1 - 0.11 12.4 0.1 9.6 6.2 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4322) HTH_psq PF05225.16 EDN05976.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF4112 PF13430.6 EDN05977.1 - 5.8e-22 77.9 0.4 7.5e-22 77.6 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) AgrD PF05931.11 EDN05977.1 - 0.019 15.0 1.0 0.032 14.2 1.0 1.3 1 0 0 1 1 1 0 Staphylococcal AgrD protein CTU2 PF10288.9 EDN05978.1 - 2.6e-12 47.0 0.2 3.6e-11 43.3 0.2 2.2 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 Lung_7-TM_R PF06814.13 EDN05979.1 - 2.2e-36 125.7 21.1 2.8e-22 79.3 6.4 3.0 1 1 1 2 2 2 2 Lung seven transmembrane receptor SurA_N_3 PF13624.6 EDN05979.1 - 2.1 8.1 5.6 0.49 10.2 0.2 2.1 2 0 0 2 2 2 0 SurA N-terminal domain DUF1308 PF07000.11 EDN05980.1 - 5e-11 42.8 0.0 1.7e-10 41.1 0.0 1.7 1 1 0 2 2 2 1 Protein of unknown function (DUF1308) WD40 PF00400.32 EDN05981.1 - 4.8e-16 58.8 6.3 1e-05 26.2 0.2 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05981.1 - 3.7e-06 27.1 0.0 0.041 14.2 0.0 4.0 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EDN05981.1 - 0.012 14.0 0.0 0.021 13.1 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz WDCP PF15390.6 EDN05981.1 - 0.069 11.5 0.0 0.097 11.0 0.0 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF1513 PF07433.11 EDN05981.1 - 0.069 12.2 0.0 2.3 7.2 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) Mito_carr PF00153.27 EDN05982.1 - 1.7e-32 111.2 2.4 5.6e-13 48.6 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein TFIIE_beta PF02186.15 EDN05983.1 - 0.13 12.6 1.3 1.3 9.3 0.0 2.7 3 0 0 3 3 3 0 TFIIE beta subunit core domain FlxA PF14282.6 EDN05983.1 - 1.8 8.6 11.8 0.29 11.2 2.0 2.5 2 0 0 2 2 2 0 FlxA-like protein Apelin PF15360.6 EDN05984.1 - 0.051 14.1 4.0 4.7 7.9 1.3 2.9 2 0 0 2 2 2 0 APJ endogenous ligand zf-C2H2_10 PF16588.5 EDN05984.1 - 0.2 11.4 4.0 0.47 10.2 4.0 1.6 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC PF00098.23 EDN05984.1 - 0.36 11.0 2.3 0.7 10.1 2.3 1.5 1 0 0 1 1 1 0 Zinc knuckle TSNAXIP1_N PF15739.5 EDN05984.1 - 0.51 10.7 6.1 0.2 12.1 0.5 2.6 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Zn_ribbon_2 PF12674.7 EDN05984.1 - 8.1 7.2 8.4 0.64 10.7 0.6 3.2 3 1 0 4 4 4 0 Putative zinc ribbon domain DIOX_N PF14226.6 EDN05986.1 - 2.8e-18 66.8 0.1 4.4e-18 66.2 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EDN05986.1 - 2.4e-12 47.2 0.0 1.5e-11 44.6 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MKT1_C PF12246.8 EDN05987.1 - 3.7e-81 271.9 0.0 5.7e-80 268.0 0.0 2.1 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EDN05987.1 - 2.3e-30 104.8 0.0 5.1e-30 103.7 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EDN05987.1 - 0.00021 21.7 0.0 0.00046 20.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDN05987.1 - 0.00039 20.7 0.0 0.00095 19.5 0.0 1.6 1 0 0 1 1 1 1 XPG I-region Thioredoxin PF00085.20 EDN05988.1 - 6.9e-57 189.8 0.0 1.8e-28 98.5 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EDN05988.1 - 7.8e-24 84.4 0.1 1.4e-23 83.5 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EDN05988.1 - 1.2e-15 57.9 0.0 1.5e-07 31.8 0.0 2.9 3 1 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EDN05988.1 - 3.7e-13 49.5 0.0 1.3e-05 24.7 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EDN05988.1 - 1.7e-07 31.4 0.0 0.21 12.0 0.0 3.4 2 1 1 3 3 3 3 Thioredoxin-like Thioredoxin_7 PF13899.6 EDN05988.1 - 3.6e-07 30.3 0.0 0.026 14.7 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like TraF PF13728.6 EDN05988.1 - 4e-07 30.1 0.0 0.012 15.5 0.0 2.2 2 0 0 2 2 2 2 F plasmid transfer operon protein ERp29_N PF07912.13 EDN05988.1 - 7.4e-06 26.1 0.0 0.0021 18.2 0.0 2.6 2 1 0 2 2 2 1 ERp29, N-terminal domain AhpC-TSA PF00578.21 EDN05988.1 - 1.7e-05 24.7 0.0 0.096 12.6 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_9 PF14595.6 EDN05988.1 - 5.1e-05 23.1 0.0 0.077 12.8 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Glutaredoxin PF00462.24 EDN05988.1 - 0.00023 21.3 0.0 0.68 10.2 0.0 2.6 2 0 0 2 2 2 2 Glutaredoxin Redoxin PF08534.10 EDN05988.1 - 0.0016 18.2 0.1 2.7 7.7 0.0 2.4 2 1 0 2 2 2 2 Redoxin HyaE PF07449.11 EDN05988.1 - 0.011 15.7 0.0 2.6 8.0 0.0 2.8 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 EDN05988.1 - 0.013 15.5 0.0 0.9 9.6 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin domain DUF836 PF05768.14 EDN05988.1 - 0.038 14.4 0.0 5 7.6 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) MFS_1 PF07690.16 EDN05989.1 - 2.8e-16 59.4 69.6 1.6e-08 33.9 9.0 2.6 2 1 1 3 3 3 3 Major Facilitator Superfamily NiFe_hyd_3_EhaA PF17367.2 EDN05989.1 - 0.049 13.8 1.7 0.28 11.3 0.1 2.6 2 0 0 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A Ebp2 PF05890.12 EDN05990.1 - 9.8e-54 182.7 26.7 1.1e-53 182.5 26.7 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 TAT_ubiq PF07706.12 EDN05990.1 - 0.044 14.0 0.0 0.42 10.9 0.0 2.4 1 1 1 2 2 2 0 Aminotransferase ubiquitination site EMC3_TMCO1 PF01956.16 EDN05990.1 - 0.46 10.2 1.8 0.46 10.2 1.8 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like SRP-alpha_N PF04086.13 EDN05990.1 - 3 7.7 18.6 3.8 7.3 18.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DNMT1-RFD PF12047.8 EDN05992.1 - 0.0037 17.3 0.0 0.008 16.2 0.0 1.5 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain Pes-10 PF07149.11 EDN05992.1 - 0.24 10.4 3.3 1.5 7.8 3.3 2.1 1 1 0 1 1 1 0 Pes-10 TruB_N PF01509.18 EDN05993.1 - 4.6e-44 150.4 0.0 1.3e-43 148.9 0.0 1.7 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EDN05993.1 - 2.2e-06 27.7 0.0 5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Apt1 PF10351.9 EDN05993.1 - 0.18 10.6 4.5 0.23 10.3 4.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain OHCU_decarbox PF09349.10 EDN05996.1 - 4.4e-47 160.4 2.3 7.7e-47 159.6 2.3 1.4 1 1 0 1 1 1 1 OHCU decarboxylase PhoD PF09423.10 EDN05998.1 - 5.8e-110 367.6 1.2 7.5e-110 367.2 1.2 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EDN05998.1 - 3.4e-34 117.2 1.4 8.2e-34 116.0 1.4 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EDN05998.1 - 6.8e-06 26.6 3.3 1.7e-05 25.3 3.3 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain WD40 PF00400.32 EDN05999.1 - 1.6e-28 98.4 8.3 4.2e-06 27.4 0.1 7.6 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN05999.1 - 8.4e-07 29.2 0.1 0.37 11.1 0.0 4.8 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EDN05999.1 - 0.00036 19.4 0.1 0.24 10.1 0.0 2.7 3 0 0 3 3 3 2 Nup133 N terminal like Nup160 PF11715.8 EDN05999.1 - 0.005 15.5 3.0 0.047 12.3 0.2 2.8 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDN05999.1 - 0.011 14.7 0.0 2.6 6.9 0.0 2.6 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SRP9-21 PF05486.12 EDN06000.1 - 7.7e-32 109.6 7.0 1.6e-31 108.6 7.0 1.5 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Ribonuc_red_sm PF00268.21 EDN06001.1 - 8.3e-76 255.1 2.3 1.1e-75 254.7 2.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain RNase_H PF00075.24 EDN06003.1 - 1.3e-12 48.1 0.0 2.9e-12 47.0 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN06003.1 - 0.058 13.2 0.1 0.2 11.5 0.1 2.0 1 1 0 1 1 1 0 Reverse transcriptase-like Pkinase_fungal PF17667.1 EDN06004.1 - 3e-139 464.3 0.0 3.9e-139 463.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN06004.1 - 3.4e-07 29.9 0.0 5.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06004.1 - 0.024 13.9 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN06004.1 - 0.076 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 EDN06005.1 - 1.4e-26 92.2 19.5 8.6e-06 26.4 0.8 6.1 5 1 1 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN06005.1 - 1.4e-12 47.8 0.1 0.00039 20.7 0.1 3.6 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN06005.1 - 0.00049 20.0 0.0 0.079 12.8 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A 2-Hacid_dh_C PF02826.19 EDN06006.1 - 9.6e-51 171.7 0.0 1.3e-50 171.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN06006.1 - 2e-14 53.4 0.0 2.5e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDN06006.1 - 1.3e-06 28.6 0.0 2.2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EDN06006.1 - 0.058 14.0 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Phosducin PF02114.16 EDN06007.1 - 1.6e-13 50.2 0.0 3.6e-12 45.8 0.0 2.1 1 1 0 1 1 1 1 Phosducin Clathrin_lg_ch PF01086.17 EDN06007.1 - 0.036 14.1 2.8 0.048 13.7 2.8 1.2 1 0 0 1 1 1 0 Clathrin light chain BET PF17035.5 EDN06008.1 - 8.8e-06 25.8 0.3 1.4e-05 25.2 0.3 1.3 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Ran_BP1 PF00638.18 EDN06009.1 - 2.2e-50 170.0 1.9 3.3e-50 169.4 1.9 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EDN06009.1 - 5e-05 23.2 0.6 0.00039 20.3 0.6 2.0 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 EDN06009.1 - 0.00066 19.9 0.1 0.00093 19.5 0.1 1.2 1 0 0 1 1 1 1 VID27 PH-like domain RAI1 PF08652.11 EDN06009.1 - 0.08 13.1 0.2 0.34 11.1 0.1 2.0 2 0 0 2 2 2 0 RAI1 like PD-(D/E)XK nuclease Glyco_transf_15 PF01793.16 EDN06011.1 - 4.4e-96 322.0 12.9 3.9e-95 318.8 12.9 1.9 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PH PF00169.29 EDN06012.1 - 5.1e-28 97.7 0.8 4.8e-13 49.5 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EDN06012.1 - 2.3e-11 44.1 1.6 7.8e-06 26.3 0.1 3.8 2 2 1 3 3 3 2 Pleckstrin homology domain PH_11 PF15413.6 EDN06012.1 - 4.8e-09 36.6 1.9 0.00069 20.0 0.9 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain DOT1 PF08123.13 EDN06013.1 - 7.5e-68 228.1 0.0 1.1e-67 227.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 ATG16 PF08614.11 EDN06014.1 - 6.3e-56 189.8 20.5 6.3e-56 189.8 20.5 1.9 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DDE_3 PF13358.6 EDN06014.1 - 2.8e-06 27.2 2.6 3.4e-06 26.9 1.3 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease Golgin_A5 PF09787.9 EDN06014.1 - 0.00055 19.5 6.4 0.00055 19.5 6.4 1.4 2 0 0 2 2 2 1 Golgin subfamily A member 5 CCDC144C PF14915.6 EDN06014.1 - 0.0054 15.9 9.5 0.0054 15.9 9.5 1.7 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region DUF4201 PF13870.6 EDN06014.1 - 0.069 12.9 11.3 0.15 11.8 11.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) AIM5 PF17050.5 EDN06014.1 - 0.48 11.3 0.2 0.48 11.3 0.2 2.9 3 0 0 3 3 3 0 Altered inheritance of mitochondria 5 KxDL PF10241.9 EDN06014.1 - 0.5 10.7 8.0 0.36 11.1 5.3 2.2 2 1 0 2 2 1 0 Uncharacterized conserved protein THOC7 PF05615.13 EDN06014.1 - 0.51 10.6 13.9 0.099 12.9 8.3 2.5 2 1 1 3 3 3 0 Tho complex subunit 7 FliT PF05400.13 EDN06014.1 - 0.57 11.0 14.9 1.9 9.4 0.2 3.2 1 1 1 2 2 2 0 Flagellar protein FliT FapA PF03961.13 EDN06014.1 - 0.79 8.3 3.1 1.2 7.7 3.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAM76 PF16046.5 EDN06014.1 - 0.8 9.0 8.3 1.2 8.5 8.3 1.2 1 0 0 1 1 1 0 FAM76 protein UPF0242 PF06785.11 EDN06014.1 - 0.84 9.7 13.6 1.3 9.1 2.1 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 EDN06014.1 - 1.7 8.9 12.7 0.38 11.0 7.5 2.5 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 EDN06014.1 - 2.4 7.0 16.0 27 3.5 14.4 2.6 2 1 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 EDN06014.1 - 3.3 8.2 11.2 10 6.6 3.9 2.8 2 1 1 3 3 3 0 Snapin/Pallidin Ras PF00071.22 EDN06015.1 - 1.4e-42 145.1 0.1 1.7e-42 144.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN06015.1 - 1.1e-20 74.1 0.0 1.9e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN06015.1 - 1e-06 28.3 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN06015.1 - 0.0011 18.5 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN06015.1 - 0.023 14.1 0.0 0.028 13.8 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EDN06015.1 - 0.056 13.2 0.0 0.072 12.9 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein EamA PF00892.20 EDN06016.1 - 0.21 11.8 15.1 0.27 11.4 15.1 1.2 1 0 0 1 1 1 0 EamA-like transporter family Gly_kinase PF02595.15 EDN06017.1 - 1.5e-133 445.4 2.5 1.8e-133 445.1 2.5 1.1 1 0 0 1 1 1 1 Glycerate kinase family MFS_1 PF07690.16 EDN06018.1 - 4e-17 62.2 31.7 1.8e-11 43.6 6.6 2.9 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN06018.1 - 2.5e-08 33.2 0.7 2.5e-08 33.2 0.7 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter Spb1_C PF07780.12 EDN06019.1 - 2.2e-85 285.6 20.7 2.2e-85 285.6 20.7 2.2 2 0 0 2 2 2 1 Spb1 C-terminal domain FtsJ PF01728.19 EDN06019.1 - 7.6e-57 192.3 0.0 1.5e-56 191.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EDN06019.1 - 0.03 14.2 0.0 0.073 12.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF4051 PF13260.6 EDN06019.1 - 0.91 9.3 2.9 2 8.2 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) PhoU_div PF01865.16 EDN06021.1 - 0.032 13.6 0.0 0.037 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF47 HHH_8 PF14716.6 EDN06021.1 - 0.13 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Helix-hairpin-helix domain Fungal_trans PF04082.18 EDN06022.1 - 0.0063 15.6 0.0 0.0087 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain EF-hand_4 PF12763.7 EDN06023.1 - 0.0014 18.5 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand DNA_ligase_A_M PF01068.21 EDN06024.1 - 2.9e-45 154.4 0.0 5.6e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDN06024.1 - 1.4e-44 152.5 0.0 2.9e-44 151.4 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EDN06024.1 - 4.1e-17 62.6 0.0 2.3e-15 57.0 0.0 2.9 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EDN06024.1 - 3.7e-16 59.8 0.0 9.1e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 RNA ligase BRCT_2 PF16589.5 EDN06024.1 - 9.2e-12 45.2 0.0 1.2e-08 35.2 0.0 2.8 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EDN06024.1 - 2.3e-05 24.7 0.0 0.00056 20.2 0.0 2.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.8 EDN06024.1 - 0.0035 17.4 0.2 0.0071 16.4 0.2 1.5 1 0 0 1 1 1 1 DNA ligase IV RNA_pol_3_Rpc31 PF11705.8 EDN06025.1 - 0.14 12.4 19.8 0.26 11.5 19.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DNA_pol_phi PF04931.13 EDN06025.1 - 0.19 9.8 15.8 0.25 9.4 15.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EDN06025.1 - 0.3 9.2 10.5 0.42 8.8 10.5 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EDN06025.1 - 0.35 10.1 13.3 0.55 9.5 13.3 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EDN06025.1 - 0.62 8.3 8.7 0.84 7.9 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 EDN06025.1 - 0.77 9.3 8.9 1.6 8.2 8.9 1.5 1 0 0 1 1 1 0 PPP4R2 Astro_capsid_p PF12226.8 EDN06025.1 - 1 8.4 13.7 1.9 7.6 13.7 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RXT2_N PF08595.11 EDN06025.1 - 1.1 9.3 6.5 2.4 8.2 6.5 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal TRAP_alpha PF03896.16 EDN06025.1 - 1.6 7.8 6.7 2.6 7.2 6.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TFB6 PF17110.5 EDN06025.1 - 1.8 8.3 4.3 2.9 7.6 4.3 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH BUD22 PF09073.10 EDN06025.1 - 1.8 7.8 7.4 2.8 7.2 7.4 1.2 1 0 0 1 1 1 0 BUD22 Sporozoite_P67 PF05642.11 EDN06025.1 - 2.4 6.1 4.4 3.7 5.5 4.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FYDLN_acid PF09538.10 EDN06025.1 - 5 7.9 19.6 0.57 10.9 14.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Cwf_Cwc_15 PF04889.12 EDN06025.1 - 5.4 6.7 17.9 0.048 13.4 10.1 1.5 2 0 0 2 2 1 0 Cwf15/Cwc15 cell cycle control protein Zn_clus PF00172.18 EDN06026.1 - 3.6e-09 36.6 8.5 8e-09 35.5 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHD PF00628.29 EDN06026.1 - 0.006 16.5 4.4 0.01 15.7 4.4 1.4 1 0 0 1 1 1 1 PHD-finger MnmE_helical PF12631.7 EDN06026.1 - 0.034 14.3 0.1 0.044 13.9 0.1 1.2 1 0 0 1 1 1 0 MnmE helical domain Sigma54_DBD PF04552.13 EDN06026.1 - 0.075 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Sigma-54, DNA binding domain Metallophos PF00149.28 EDN06028.1 - 1.3e-30 107.4 0.0 2.9e-22 80.2 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDN06028.1 - 0.059 13.8 0.1 0.15 12.5 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain COA2 PF17051.5 EDN06029.1 - 0.042 13.9 0.0 0.082 13.0 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase assembly factor 2 DUF4646 PF15496.6 EDN06030.1 - 1.2e-08 35.6 0.0 2.8e-08 34.4 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4646) JAKMIP_CC3 PF16034.5 EDN06030.1 - 2.2 8.2 7.9 1.2 9.1 4.7 1.9 1 1 1 2 2 2 0 JAKMIP CC3 domain ALG3 PF05208.13 EDN06031.1 - 4.6e-93 312.5 10.6 5.8e-93 312.2 10.6 1.0 1 0 0 1 1 1 1 ALG3 protein eIF-1a PF01176.19 EDN06032.1 - 1.6e-20 72.7 0.1 2.2e-20 72.2 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Pkinase PF00069.25 EDN06033.1 - 9.8e-59 198.9 0.0 1.5e-58 198.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06033.1 - 3.6e-36 124.8 0.0 6.3e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EDN06033.1 - 3.2e-24 84.8 9.5 1.1e-11 44.7 1.1 2.4 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EDN06033.1 - 4.4e-14 52.1 19.8 1.9e-12 46.9 9.6 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EDN06033.1 - 2.9e-13 50.3 1.5 2.9e-13 50.3 1.5 2.7 3 0 0 3 3 3 1 Protein kinase C terminal domain C2 PF00168.30 EDN06033.1 - 8e-07 29.3 0.0 1.5e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EDN06033.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Prok-RING_1 PF14446.6 EDN06033.1 - 0.44 10.5 8.0 1.1 9.2 8.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 TFCD_C PF12612.8 EDN06035.1 - 7.9e-38 130.2 0.0 2.6e-37 128.5 0.0 2.0 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 EDN06035.1 - 3.3e-09 36.2 6.4 1.1 9.7 0.0 7.7 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 EDN06035.1 - 1.4e-05 25.4 0.5 11 6.5 0.0 5.6 6 1 0 6 6 6 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EDN06035.1 - 0.0019 18.8 0.0 8.1 7.1 0.0 3.8 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDN06035.1 - 0.0035 17.8 0.8 17 6.0 0.0 5.5 5 0 0 5 5 5 1 HEAT-like repeat IFRD PF05004.13 EDN06035.1 - 0.12 11.4 0.2 0.97 8.5 0.0 2.5 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) RRM_1 PF00076.22 EDN06036.1 - 1e-23 82.9 0.3 1.3e-11 44.1 0.2 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN06036.1 - 0.0004 20.2 0.0 0.76 9.7 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EDN06036.1 - 0.00052 19.6 0.0 0.0035 16.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1027 PF06265.11 EDN06036.1 - 0.18 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) ATP-synt_D PF01813.17 EDN06037.1 - 2.6e-71 239.5 1.5 3.6e-71 239.1 1.5 1.2 1 0 0 1 1 1 1 ATP synthase subunit D PHM7_cyt PF14703.6 EDN06037.1 - 0.0044 17.3 2.2 0.059 13.6 0.4 2.3 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter HtrL_YibB PF09612.10 EDN06037.1 - 0.0078 15.8 0.3 0.012 15.1 0.3 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) CobA_CobO_BtuR PF02572.15 EDN06037.1 - 0.062 13.6 3.3 0.59 10.4 0.0 2.5 1 1 1 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF3919 PF13057.6 EDN06037.1 - 0.09 12.4 1.8 0.14 11.8 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) ISG65-75 PF11727.8 EDN06037.1 - 0.15 11.3 7.9 0.11 11.7 3.7 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein RICH PF05062.12 EDN06037.1 - 0.18 12.1 4.7 0.31 11.4 1.3 2.3 2 0 0 2 2 2 0 RICH domain TPR_14 PF13428.6 EDN06038.1 - 2.2e-16 59.1 15.5 1.1 10.2 0.0 12.1 9 2 4 13 13 13 3 Tetratricopeptide repeat Suf PF05843.14 EDN06038.1 - 5.1e-10 39.8 14.7 0.14 12.1 0.1 6.8 4 1 2 6 6 6 3 Suppressor of forked protein (Suf) TPR_8 PF13181.6 EDN06038.1 - 9.4e-09 34.8 2.8 0.4 11.0 0.0 7.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN06038.1 - 6e-08 33.1 1.7 1 9.9 0.0 6.6 7 1 1 8 8 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDN06038.1 - 2.9e-07 30.7 3.9 3.3 8.1 0.0 7.2 6 1 0 6 6 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDN06038.1 - 3.9e-07 30.1 13.9 0.3 11.1 0.1 7.2 7 0 0 7 7 7 2 Mad3/BUB1 homology region 1 TPR_15 PF13429.6 EDN06038.1 - 1.2e-06 28.0 5.6 0.0032 16.7 0.2 4.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN06038.1 - 5.5e-06 26.1 11.2 3.5 8.0 0.0 8.0 8 0 0 8 8 7 1 Tetratricopeptide repeat HAT PF02184.16 EDN06038.1 - 0.00062 19.7 2.7 2.8 8.0 0.0 5.7 5 0 0 5 5 5 1 HAT (Half-A-TPR) repeat TPR_MalT PF17874.1 EDN06038.1 - 0.013 14.9 0.0 19 4.5 0.0 4.2 4 1 0 4 4 4 0 MalT-like TPR region RPN7 PF10602.9 EDN06038.1 - 0.016 14.9 0.3 1.7 8.3 0.1 3.5 3 1 0 3 3 3 0 26S proteasome subunit RPN7 TPR_10 PF13374.6 EDN06038.1 - 0.017 15.0 9.6 14 5.7 0.0 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat MIT PF04212.18 EDN06038.1 - 0.059 13.5 0.7 5.6 7.1 0.0 4.2 5 0 0 5 5 3 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.14 EDN06038.1 - 0.061 14.0 7.3 6.9 7.6 0.0 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDN06038.1 - 0.12 12.1 0.2 1.2 8.9 0.0 3.0 3 0 0 3 3 2 0 TPR repeat NRDE-2 PF08424.10 EDN06038.1 - 0.15 11.1 14.2 0.31 10.1 0.8 6.2 3 3 2 5 5 5 0 NRDE-2, necessary for RNA interference TPR_17 PF13431.6 EDN06038.1 - 0.16 12.4 9.2 1.8 9.2 0.0 6.7 9 0 0 9 9 6 0 Tetratricopeptide repeat PPR PF01535.20 EDN06038.1 - 0.69 10.3 4.0 1.3e+02 3.2 0.0 5.1 5 0 0 5 5 4 0 PPR repeat TPR_6 PF13174.6 EDN06038.1 - 1.1 10.0 12.1 44 5.0 0.0 7.7 9 0 0 9 9 8 0 Tetratricopeptide repeat Sec7 PF01369.20 EDN06040.1 - 2.1e-60 203.6 0.0 3.1e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EDN06040.1 - 3.1e-06 27.2 0.0 1.5e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal RhoGEF PF00621.20 EDN06041.1 - 1.4e-21 77.5 0.0 3.2e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.8 EDN06041.1 - 7.4e-06 25.8 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) OmpH PF03938.14 EDN06041.1 - 0.034 14.5 0.2 0.034 14.5 0.2 2.4 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Nod1 PF17114.5 EDN06041.1 - 0.051 13.7 0.0 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 LXG PF04740.12 EDN06041.1 - 5.4 6.7 5.7 2.1 8.0 0.0 3.1 4 0 0 4 4 4 0 LXG domain of WXG superfamily ATP_bind_3 PF01171.20 EDN06043.1 - 8e-07 29.0 0.2 1.7e-05 24.7 0.0 2.4 3 0 0 3 3 3 1 PP-loop family Mito_carr PF00153.27 EDN06044.1 - 2.6e-47 158.7 1.6 8.7e-22 76.9 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Cupin_5 PF06172.11 EDN06045.1 - 1.8e-48 164.3 0.0 2.3e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) DUF3337 PF11816.8 EDN06046.1 - 9.9e-39 132.9 0.0 2.5e-38 131.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EDN06046.1 - 1.1e-16 60.9 20.4 2.8e-05 24.8 0.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN06046.1 - 0.0003 21.0 0.2 0.012 15.9 0.2 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN06046.1 - 0.0035 16.1 2.3 0.12 10.9 0.1 2.5 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Glyco_hydro_18 PF00704.28 EDN06047.1 - 4.1e-63 214.0 0.0 5e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GHL15 PF14885.6 EDN06047.1 - 0.034 14.1 0.1 0.088 12.7 0.1 1.6 1 1 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 Lipase_GDSL_2 PF13472.6 EDN06047.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Pkinase PF00069.25 EDN06048.1 - 2.8e-45 154.7 0.0 3.3e-44 151.3 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06048.1 - 7.7e-20 71.3 0.0 1.5e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN06048.1 - 0.018 14.9 0.8 0.029 14.3 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDN06048.1 - 0.041 12.8 0.0 0.081 11.9 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EDN06048.1 - 0.17 11.2 0.0 0.52 9.6 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 EDN06048.1 - 0.21 10.3 0.8 15 4.2 0.8 2.3 2 0 0 2 2 2 0 Fungal protein kinase Ribosomal_L11 PF00298.19 EDN06049.1 - 7e-28 96.9 0.3 1.2e-27 96.2 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EDN06049.1 - 1.7e-26 91.8 0.2 6.7e-26 89.9 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Svf1_C PF17187.4 EDN06050.1 - 3.4e-59 199.4 0.0 6.3e-59 198.5 0.0 1.5 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EDN06050.1 - 5.8e-55 185.8 0.0 8.4e-55 185.3 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain TAF PF02969.17 EDN06051.1 - 0.0077 16.4 0.3 0.015 15.5 0.1 1.6 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) AbiEi_4 PF13338.6 EDN06051.1 - 0.11 12.6 0.9 0.11 12.6 0.9 2.6 3 0 0 3 3 3 0 Transcriptional regulator, AbiEi antitoxin Acetyltransf_1 PF00583.25 EDN06053.1 - 2e-05 24.8 0.2 4.8e-05 23.6 0.2 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN06053.1 - 0.0076 16.7 0.2 0.062 13.7 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EDN06053.1 - 0.031 14.3 0.3 0.059 13.4 0.3 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_10 PF13673.7 EDN06053.1 - 0.07 13.1 0.0 0.48 10.4 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain K_channel_TID PF07941.11 EDN06053.1 - 0.075 13.5 5.6 0.15 12.5 5.6 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Acetyltransf_9 PF13527.7 EDN06053.1 - 0.13 12.3 0.0 2.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain AAA_9 PF12781.7 EDN06054.1 - 1.2e-74 250.2 0.8 1.2e-74 250.2 0.8 3.6 4 1 1 5 5 5 1 ATP-binding dynein motor region MT PF12777.7 EDN06054.1 - 1.6e-39 135.9 5.1 2.7e-39 135.2 5.1 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EDN06054.1 - 1.4e-30 105.8 0.0 3.9e-27 94.7 0.0 3.1 3 0 0 3 3 3 2 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EDN06054.1 - 2.1e-28 99.2 0.0 4.7e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_8 PF12780.7 EDN06054.1 - 0.00015 21.2 0.6 0.00034 20.0 0.6 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 WXG100 PF06013.12 EDN06054.1 - 0.029 14.6 0.6 0.029 14.6 0.6 3.3 3 0 0 3 3 3 0 Proteins of 100 residues with WXG CLZ PF16526.5 EDN06054.1 - 0.035 14.5 0.8 0.035 14.5 0.8 4.1 5 1 0 5 5 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4482 PF14818.6 EDN06054.1 - 0.04 14.8 11.1 5.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) G-gamma PF00631.22 EDN06054.1 - 0.069 13.2 0.0 0.33 11.0 0.0 2.3 1 0 0 1 1 1 0 GGL domain Vps23_core PF09454.10 EDN06054.1 - 0.091 12.7 0.3 0.34 10.9 0.2 2.0 2 0 0 2 2 1 0 Vps23 core domain DUF948 PF06103.11 EDN06054.1 - 0.32 11.3 7.9 8.6 6.7 0.2 4.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) ERM PF00769.19 EDN06054.1 - 0.38 10.5 29.4 0.046 13.5 14.2 2.6 3 0 0 3 3 2 0 Ezrin/radixin/moesin family Phage_GP20 PF06810.11 EDN06054.1 - 0.44 10.3 17.8 0.47 10.3 7.7 3.3 3 0 0 3 3 3 0 Phage minor structural protein GP20 zf-C4H2 PF10146.9 EDN06054.1 - 0.53 10.6 0.0 0.53 10.6 0.0 3.0 3 0 0 3 3 3 0 Zinc finger-containing protein DUF3450 PF11932.8 EDN06054.1 - 0.57 9.4 16.7 0.18 11.1 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 EDN06054.1 - 0.97 9.6 28.1 0.077 13.2 0.7 3.7 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 EDN06054.1 - 1.7 8.7 12.8 1.9 8.5 1.6 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 EDN06054.1 - 2 7.4 15.2 3.4 6.7 8.9 2.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2205 PF10224.9 EDN06054.1 - 4.3 7.4 10.8 4 7.5 4.7 3.4 2 1 1 3 3 3 0 Short coiled-coil protein AAA_6 PF12774.7 EDN06055.1 - 4e-124 413.9 0.0 1.5e-123 412.0 0.0 2.1 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EDN06055.1 - 2.1e-121 406.3 10.2 2.1e-121 406.3 10.2 3.6 4 1 1 5 5 5 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EDN06055.1 - 4.4e-117 391.6 5.6 4.4e-117 391.6 5.6 3.5 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 EDN06055.1 - 2.1e-41 141.4 0.0 1.6e-36 125.5 0.0 3.8 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_5 PF07728.14 EDN06055.1 - 2e-23 82.9 0.1 1.7e-10 41.1 0.0 4.9 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EDN06055.1 - 7.8e-18 64.8 0.1 3.3e-17 62.8 0.1 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EDN06055.1 - 2.1e-10 41.0 1.6 0.0062 16.8 0.0 5.1 5 0 0 5 5 4 3 AAA domain AAA PF00004.29 EDN06055.1 - 2.5e-08 34.4 0.0 0.00032 21.1 0.0 3.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EDN06055.1 - 4e-06 27.1 2.1 0.16 12.1 0.0 4.0 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.6 EDN06055.1 - 8.4e-06 26.3 0.1 3.1 8.1 0.0 4.8 4 0 0 4 4 4 1 AAA ATPase domain AAA_18 PF13238.6 EDN06055.1 - 2.5e-05 24.8 0.1 0.53 10.8 0.0 4.5 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.17 EDN06055.1 - 0.0016 18.2 0.1 0.47 10.2 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_30 PF13604.6 EDN06055.1 - 0.0032 17.2 0.5 24 4.6 0.0 3.7 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 EDN06055.1 - 0.0045 16.4 2.0 0.42 10.0 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EDN06055.1 - 0.0046 16.0 0.0 0.018 14.1 0.0 2.0 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_24 PF13479.6 EDN06055.1 - 0.012 15.4 1.4 6.8 6.4 0.0 4.3 5 0 0 5 5 5 0 AAA domain ABC_tran PF00005.27 EDN06055.1 - 0.012 16.1 0.0 1.6 9.2 0.0 3.5 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 EDN06055.1 - 0.016 15.1 0.0 6.9 6.5 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase AAA_19 PF13245.6 EDN06055.1 - 0.022 15.1 2.7 0.17 12.2 0.0 3.6 4 0 0 4 4 3 0 AAA domain RNA_helicase PF00910.22 EDN06055.1 - 0.023 15.1 0.1 28 5.2 0.0 3.8 3 0 0 3 3 3 0 RNA helicase AAA_25 PF13481.6 EDN06055.1 - 0.025 14.2 0.2 0.2 11.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.6 EDN06055.1 - 0.029 14.4 0.0 1.1 9.3 0.0 3.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EDN06055.1 - 0.03 13.6 0.1 4.8 6.4 0.1 3.0 2 0 0 2 2 2 0 Zeta toxin Spectrin PF00435.21 EDN06055.1 - 0.03 14.8 4.9 0.31 11.6 0.4 4.7 3 1 1 4 4 4 0 Spectrin repeat AAA_29 PF13555.6 EDN06055.1 - 0.038 13.7 0.0 4.7 7.0 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_11 PF13086.6 EDN06055.1 - 0.73 9.6 3.7 0.94 9.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain Ribonuclease_3 PF00636.26 EDN06056.1 - 2e-43 147.3 0.0 1.5e-20 73.8 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDN06056.1 - 7.9e-27 94.0 0.0 1.1e-14 54.6 0.0 3.5 2 1 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EDN06056.1 - 6.6e-20 71.1 0.0 8e-19 67.6 0.0 2.6 2 0 0 2 2 2 1 Dicer dimerisation domain ResIII PF04851.15 EDN06056.1 - 0.00022 21.3 0.3 0.00053 20.0 0.3 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDN06056.1 - 0.0013 18.6 0.1 0.0024 17.7 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 EDN06056.1 - 0.0032 18.2 0.1 0.1 13.3 0.1 2.6 2 0 0 2 2 2 1 Double-stranded RNA binding motif CAF1 PF04857.20 EDN06056.1 - 0.0099 15.1 0.1 0.43 9.7 0.0 2.5 3 0 0 3 3 3 1 CAF1 family ribonuclease TAP42 PF04177.12 EDN06057.1 - 2e-102 342.6 2.4 2.3e-102 342.4 2.4 1.0 1 0 0 1 1 1 1 TAP42-like family Lipase_GDSL_2 PF13472.6 EDN06058.1 - 1.8e-06 28.5 0.1 0.0012 19.2 0.0 2.8 1 1 1 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDN06058.1 - 2.9e-05 24.2 0.0 0.0016 18.4 0.0 2.1 1 1 1 2 2 2 2 GDSL-like Lipase/Acylhydrolase Porphobil_deam PF01379.20 EDN06059.1 - 3.5e-71 238.9 0.0 5.5e-71 238.3 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EDN06059.1 - 4.2e-18 65.5 0.4 7.4e-18 64.7 0.4 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Lon_C PF05362.13 EDN06060.1 - 4.4e-69 232.1 0.4 9.1e-69 231.1 0.4 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EDN06060.1 - 1.4e-24 87.0 0.0 5.9e-24 85.0 0.0 2.2 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EDN06060.1 - 2.6e-24 86.2 0.0 5.8e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 EDN06060.1 - 7.7e-08 32.4 0.0 3.1e-07 30.5 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EDN06060.1 - 1.1e-07 31.7 0.0 3.6e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EDN06060.1 - 2.3e-06 28.1 0.0 8.3e-06 26.3 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EDN06060.1 - 3e-05 23.4 0.0 6.3e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EDN06060.1 - 4.3e-05 23.3 0.0 0.00013 21.8 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EDN06060.1 - 0.00014 21.7 0.0 0.00042 20.2 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDN06060.1 - 0.00031 20.5 0.5 0.0012 18.6 0.0 2.2 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDN06060.1 - 0.00053 20.3 0.3 0.0091 16.3 0.0 3.0 3 1 0 3 3 1 1 AAA domain AAA_2 PF07724.14 EDN06060.1 - 0.00065 19.9 0.0 0.0025 18.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDN06060.1 - 0.0018 18.5 0.0 0.0042 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Birna_VP4 PF01768.16 EDN06060.1 - 0.0049 16.7 0.4 0.016 15.0 0.1 2.1 2 1 0 2 2 1 1 Birnavirus VP4 protein AAA_7 PF12775.7 EDN06060.1 - 0.016 14.7 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EDN06060.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN06060.1 - 0.019 15.3 0.0 0.067 13.6 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EDN06060.1 - 0.021 14.8 0.0 0.072 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EDN06060.1 - 0.024 14.0 0.2 0.063 12.6 0.2 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EDN06060.1 - 0.027 13.9 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EDN06060.1 - 0.035 14.0 0.0 0.12 12.3 0.0 1.9 2 0 0 2 2 1 0 NACHT domain TniB PF05621.11 EDN06060.1 - 0.058 12.8 0.0 0.17 11.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein TsaE PF02367.17 EDN06060.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EDN06060.1 - 0.062 13.2 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 EDN06060.1 - 0.063 13.0 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDN06060.1 - 0.064 13.8 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDN06060.1 - 0.066 12.4 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 EDN06060.1 - 0.066 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDN06060.1 - 0.071 13.4 0.1 0.27 11.5 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDN06060.1 - 0.082 13.4 0.1 0.082 13.4 0.1 3.1 1 1 1 2 2 1 0 AAA domain AAA_11 PF13086.6 EDN06060.1 - 0.082 12.7 0.2 0.082 12.7 0.2 2.4 1 1 1 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDN06060.1 - 0.085 12.8 1.2 0.76 9.7 0.0 2.8 3 0 0 3 3 2 0 NTPase Zeta_toxin PF06414.12 EDN06060.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_PrkA PF08298.11 EDN06060.1 - 0.092 11.6 0.1 0.6 9.0 0.0 2.0 2 0 0 2 2 2 0 PrkA AAA domain ABC_tran PF00005.27 EDN06060.1 - 0.71 10.4 3.1 1.7 9.2 0.1 2.8 1 1 1 2 2 2 0 ABC transporter Laps PF10169.9 EDN06060.1 - 3.8 8.1 6.2 5.5 7.6 0.1 2.6 1 1 1 2 2 2 0 Learning-associated protein Ribosomal_L23 PF00276.20 EDN06061.1 - 2.2e-11 43.9 0.0 3.7e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 RIO1 PF01163.22 EDN06062.1 - 7.1e-33 113.8 0.1 2.6e-19 69.6 0.0 2.2 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 EDN06062.1 - 3.1e-07 30.6 0.1 0.00049 20.1 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDN06062.1 - 3.6e-05 23.2 0.0 0.0041 16.5 0.0 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NOA36 PF06524.12 EDN06062.1 - 4.3 6.6 5.9 5.8 6.1 5.9 1.1 1 0 0 1 1 1 0 NOA36 protein RPN1_RPN2_N PF17781.1 EDN06063.1 - 2.3e-118 395.1 4.1 3.9e-118 394.4 4.1 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EDN06063.1 - 7.1e-30 102.8 0.0 1.3e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EDN06063.1 - 1.1e-14 53.9 21.1 2.6e-05 24.4 0.3 8.6 9 1 1 10 10 10 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDN06063.1 - 0.00026 21.3 1.4 0.36 11.2 0.1 4.4 4 2 1 5 5 5 1 HEAT repeats T2SSF PF00482.23 EDN06063.1 - 0.089 12.7 3.4 7 6.6 0.0 4.1 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F TPR_12 PF13424.6 EDN06063.1 - 0.52 10.6 2.4 6.9 7.0 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase_fungal PF17667.1 EDN06067.1 - 1.1e-142 475.7 0.0 1.3e-142 475.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN06067.1 - 2.8e-08 33.4 0.0 4.6e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06067.1 - 0.037 13.3 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN06067.1 - 0.076 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family rve PF00665.26 EDN06068.1 - 8.3e-11 42.1 0.0 3.6e-10 40.1 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 EDN06068.1 - 6.4e-07 29.3 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_10 PF16588.5 EDN06068.1 - 0.031 14.0 3.0 0.058 13.1 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN06068.1 - 0.032 14.1 0.0 0.09 12.7 0.0 1.7 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN06068.1 - 0.095 12.5 0.1 0.29 11.0 0.1 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_2 PF14223.6 EDN06068.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Kdo PF06293.14 EDN06069.1 - 0.00012 21.6 0.2 0.00024 20.5 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN06069.1 - 0.03 13.9 0.0 0.069 12.7 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 EDN06069.1 - 0.047 13.6 6.5 0.11 12.4 0.1 3.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDN06069.1 - 0.06 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EDN06069.1 - 0.16 11.3 0.0 0.5 9.7 0.0 1.8 1 0 0 1 1 1 0 Protein kinase domain ETF_alpha PF00766.19 EDN06070.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Electron transfer flavoprotein FAD-binding domain Rnf-Nqr PF02508.14 EDN06071.1 - 0.028 14.4 5.5 0.22 11.5 5.0 2.1 1 1 0 1 1 1 0 Rnf-Nqr subunit, membrane protein zf-RING_11 PF17123.5 EDN06072.1 - 0.35 10.6 0.9 0.95 9.3 0.9 1.7 1 0 0 1 1 1 0 RING-like zinc finger Integrase_H2C2 PF17921.1 EDN06073.1 - 0.021 14.9 0.6 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Integrase zinc binding domain Thioredoxin_9 PF14595.6 EDN06073.1 - 0.057 13.2 0.0 0.53 10.0 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin RTC4 PF14474.6 EDN06076.1 - 4.9e-27 94.5 0.0 9e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 RTC4-like domain Myb_DNA-bind_6 PF13921.6 EDN06076.1 - 0.00015 21.9 2.4 0.00015 21.9 2.4 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN06076.1 - 0.0023 18.1 2.2 0.0023 18.1 2.2 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain RHSP PF07999.11 EDN06076.1 - 0.2 10.4 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein Helo_like_N PF17111.5 EDN06077.1 - 2.7e-43 147.8 6.5 3e-41 141.1 1.4 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins TBCA PF02970.16 EDN06077.1 - 0.088 13.1 4.6 8.5 6.8 0.6 3.3 1 1 3 4 4 4 0 Tubulin binding cofactor A Toxin_2 PF00451.19 EDN06077.1 - 0.53 10.6 2.3 8.3 6.8 0.1 2.2 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 Casc1_N PF15927.5 EDN06078.1 - 0.26 10.9 8.6 0.85 9.3 8.2 1.9 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Zn_clus PF00172.18 EDN06081.1 - 8.4e-05 22.6 2.0 0.00025 21.1 2.0 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2783 PF10932.8 EDN06083.1 - 0.06 13.0 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) bZIP_1 PF00170.21 EDN06084.1 - 0.1 12.7 0.6 0.19 11.8 0.6 1.4 1 0 0 1 1 1 0 bZIP transcription factor Lac_bphage_repr PF06543.12 EDN06088.1 - 0.3 11.1 1.8 0.68 10.0 1.8 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor PRR20 PF15708.5 EDN06089.1 - 0.045 13.6 0.4 0.07 13.0 0.4 1.2 1 0 0 1 1 1 0 Proline-rich protein family 20 RVT_1 PF00078.27 EDN06090.1 - 1.4e-37 129.3 0.0 2.7e-37 128.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN06090.1 - 1.1e-23 83.3 0.2 4.3e-23 81.4 0.2 2.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN06090.1 - 6e-12 46.0 0.0 1.5e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN06090.1 - 1.3e-05 25.0 0.4 0.00018 21.3 0.0 2.4 2 0 0 2 2 2 1 Reverse transcriptase-like Exo_endo_phos PF03372.23 EDN06090.1 - 6e-05 22.7 0.2 0.00016 21.3 0.2 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PuR_N PF09182.10 EDN06090.1 - 0.0012 18.8 0.2 0.0047 16.8 0.1 2.1 2 0 0 2 2 2 1 Bacterial purine repressor, N-terminal zf-CCHC PF00098.23 EDN06090.1 - 0.011 15.8 4.6 0.031 14.3 4.6 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-C3HC4 PF00097.25 EDN06091.1 - 9.8e-05 22.2 3.7 0.0003 20.6 3.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN06091.1 - 0.00026 20.8 9.2 0.00049 19.9 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HAUS-augmin3 PF14932.6 EDN06091.1 - 0.00062 19.4 1.3 0.00091 18.9 1.3 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 ADIP PF11559.8 EDN06091.1 - 0.0024 17.9 2.5 0.0039 17.3 2.5 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Lebercilin PF15619.6 EDN06091.1 - 0.0028 17.3 4.2 0.0048 16.6 4.2 1.3 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Interferon PF00143.19 EDN06091.1 - 0.0069 16.6 0.1 0.0096 16.1 0.1 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain ATG16 PF08614.11 EDN06091.1 - 0.0086 16.3 1.2 0.01 16.1 1.2 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) zf-C3HC4_2 PF13923.6 EDN06091.1 - 0.013 15.4 7.5 0.039 13.8 7.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UPF0242 PF06785.11 EDN06091.1 - 0.013 15.6 3.4 0.019 15.1 3.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF848 PF05852.11 EDN06091.1 - 0.018 15.2 0.5 0.024 14.7 0.5 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Fez1 PF06818.15 EDN06091.1 - 0.019 15.4 3.3 0.027 14.9 3.3 1.1 1 0 0 1 1 1 0 Fez1 DegS PF05384.11 EDN06091.1 - 0.019 14.4 4.5 0.028 13.9 4.5 1.2 1 0 0 1 1 1 0 Sensor protein DegS Seryl_tRNA_N PF02403.22 EDN06091.1 - 0.02 15.1 0.5 0.029 14.6 0.5 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.15 EDN06091.1 - 0.021 14.6 2.4 0.038 13.8 2.4 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.6 EDN06091.1 - 0.023 14.1 0.3 0.03 13.7 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 EDN06091.1 - 0.029 14.6 2.5 0.053 13.7 2.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HAUS5 PF14817.6 EDN06091.1 - 0.03 13.1 4.0 0.037 12.8 4.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 Tropomyosin_1 PF12718.7 EDN06091.1 - 0.042 14.0 4.5 0.059 13.5 4.5 1.1 1 0 0 1 1 1 0 Tropomyosin like Troponin PF00992.20 EDN06091.1 - 0.054 13.8 4.7 0.095 13.0 4.7 1.3 1 0 0 1 1 1 0 Troponin zf-RING_5 PF14634.6 EDN06091.1 - 0.062 13.3 7.4 0.14 12.1 7.4 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Macoilin PF09726.9 EDN06091.1 - 0.063 11.8 4.1 0.079 11.5 4.1 1.0 1 0 0 1 1 1 0 Macoilin family Flg_hook PF02120.16 EDN06091.1 - 0.072 13.0 0.6 0.097 12.6 0.6 1.2 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK APC_N_CC PF16689.5 EDN06091.1 - 0.078 13.0 1.4 0.13 12.3 1.4 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Spc29 PF17082.5 EDN06091.1 - 0.089 12.6 1.3 0.11 12.3 1.3 1.1 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF1664 PF07889.12 EDN06091.1 - 0.12 12.4 2.2 0.18 11.9 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CALCOCO1 PF07888.11 EDN06091.1 - 0.13 11.2 6.6 0.19 10.6 6.6 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Tox-REase-9 PF15650.6 EDN06091.1 - 0.13 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 DUF2730 PF10805.8 EDN06091.1 - 0.13 12.4 0.3 0.19 11.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) HALZ PF02183.18 EDN06091.1 - 0.16 12.2 1.7 1.3 9.3 0.2 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF4164 PF13747.6 EDN06091.1 - 0.16 12.2 5.2 0.31 11.3 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Trimer_CC PF08954.11 EDN06091.1 - 0.22 11.1 6.4 0.42 10.2 6.4 1.4 1 0 0 1 1 1 0 Trimerisation motif Metal_resist PF13801.6 EDN06091.1 - 4.3 7.5 6.6 0.48 10.6 2.2 1.6 2 0 0 2 2 1 0 Heavy-metal resistance DUF3435 PF11917.8 EDN06092.1 - 5.8e-163 542.7 0.7 9.2e-163 542.0 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2 PF00096.26 EDN06092.1 - 0.11 13.0 0.3 22 5.7 0.0 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Nexin_C PF08628.12 EDN06093.1 - 0.0066 17.0 1.1 0.0082 16.7 0.8 1.4 1 1 0 1 1 1 1 Sorting nexin C terminal SNN_linker PF09050.10 EDN06094.1 - 0.87 9.4 2.5 1.6 8.6 2.5 1.4 1 0 0 1 1 1 0 Stannin unstructured linker DUF4187 PF13821.6 EDN06095.1 - 3.9e-22 77.8 3.4 8.8e-22 76.7 3.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EDN06095.1 - 1.5e-09 37.6 0.3 1.1e-08 34.8 0.3 2.4 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDN06095.1 - 0.04 14.0 1.0 0.46 10.6 0.1 2.8 2 0 0 2 2 2 0 G-patch domain CPSase_L_D2 PF02786.17 EDN06097.1 - 5.5e-107 356.0 0.0 6e-84 280.8 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EDN06097.1 - 6.5e-41 139.5 0.0 1.9e-40 138.0 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EDN06097.1 - 3.7e-18 65.7 0.0 2.8e-08 33.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDN06097.1 - 1.1e-17 64.3 0.5 1e-07 31.7 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EDN06097.1 - 5.4e-11 42.4 0.0 0.00034 20.3 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 EDN06097.1 - 2.7e-05 23.8 0.0 0.018 14.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 EDN06097.1 - 0.00017 21.4 0.2 0.35 10.6 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 EDN06097.1 - 0.0013 18.3 0.0 1.9 8.0 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain zf-MYND PF01753.18 EDN06098.1 - 2e-09 37.4 8.2 2e-09 37.4 8.2 2.3 2 0 0 2 2 2 1 MYND finger SET PF00856.28 EDN06098.1 - 0.0018 18.7 0.2 0.039 14.4 0.2 2.5 1 1 0 1 1 1 1 SET domain SPT2 PF08243.11 EDN06099.1 - 3.6e-07 30.7 15.7 3.6e-07 30.7 15.7 2.7 2 1 1 3 3 3 1 SPT2 chromatin protein Ribosomal_60s PF00428.19 EDN06100.1 - 7.9e-16 58.4 9.4 8.6e-16 58.3 9.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 EDN06100.1 - 0.02 13.4 1.0 0.022 13.3 1.0 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3824 PF12868.7 EDN06100.1 - 0.44 11.2 6.3 0.54 10.9 6.3 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Ribosomal_S19 PF00203.21 EDN06101.1 - 1e-33 115.0 0.3 1.4e-33 114.6 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Carb_kinase PF01256.17 EDN06102.1 - 1e-30 107.0 0.0 1.6e-30 106.4 0.0 1.3 1 1 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EDN06102.1 - 0.0095 15.3 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family DUF3245 PF11595.8 EDN06104.1 - 0.029 14.8 0.7 0.096 13.2 0.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) DUF3886 PF13025.6 EDN06104.1 - 0.057 13.6 0.4 0.13 12.4 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) zf-C2H2_4 PF13894.6 EDN06104.1 - 0.27 12.2 3.9 0.34 11.9 2.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Methyltransf_16 PF10294.9 EDN06106.1 - 0.026 14.3 0.0 0.82 9.4 0.0 2.2 2 0 0 2 2 2 0 Lysine methyltransferase PRR22 PF15776.5 EDN06106.1 - 0.11 11.8 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Proline-rich protein family 22 Cys_Met_Meta_PP PF01053.20 EDN06107.1 - 5.1e-112 374.2 0.0 9.7e-98 327.2 0.0 2.0 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDN06107.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II RNA_pol_Rbc25 PF08292.12 EDN06108.1 - 2.4e-33 115.1 0.1 6.7e-33 113.7 0.1 1.8 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 Pkinase_fungal PF17667.1 EDN06108.1 - 4e-15 55.5 0.0 6.6e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SHS2_Rpb7-N PF03876.17 EDN06108.1 - 3.1e-14 53.1 0.0 7.5e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 HlyIII PF03006.20 EDN06108.1 - 3.7e-05 23.6 0.3 6e-05 22.9 0.3 1.3 1 0 0 1 1 1 1 Haemolysin-III related S1 PF00575.23 EDN06108.1 - 0.065 13.6 0.1 0.17 12.3 0.1 1.7 1 1 0 1 1 1 0 S1 RNA binding domain DUF3784 PF12650.7 EDN06108.1 - 0.19 11.9 1.3 5.7 7.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) NUFIP1 PF10453.9 EDN06109.1 - 1.7e-13 50.2 8.1 9.5e-13 47.8 8.1 2.4 1 1 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Dishevelled PF02377.15 EDN06112.1 - 0.00073 20.0 1.3 0.00073 20.0 1.3 2.0 1 1 1 2 2 2 1 Dishevelled specific domain eIF3_subunit PF08597.10 EDN06112.1 - 0.0037 17.2 5.6 0.0048 16.9 5.6 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit AP3D1 PF06375.11 EDN06112.1 - 0.067 13.4 6.5 0.1 12.9 6.5 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Rrn6 PF10214.9 EDN06112.1 - 0.11 11.0 6.9 0.12 10.8 6.9 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF2828 PF11443.8 EDN06112.1 - 0.13 10.3 6.3 0.15 10.1 6.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RAG1_imp_bd PF12560.8 EDN06112.1 - 5.6 6.4 10.4 7.2 6.1 10.4 1.2 1 0 0 1 1 1 0 RAG1 importin binding GPI-anchored PF10342.9 EDN06113.1 - 1.8e-16 60.7 0.0 1.8e-16 60.7 0.0 2.5 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Pex14_N PF04695.13 EDN06113.1 - 0.8 10.4 8.6 1.2 9.8 8.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SOG2 PF10428.9 EDN06113.1 - 3.1 6.9 14.5 3.6 6.7 14.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein FSA_C PF10479.9 EDN06113.1 - 7 4.7 14.8 8.5 4.4 14.8 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FAM199X PF15814.5 EDN06113.1 - 7.4 5.5 9.7 9.2 5.2 9.7 1.2 1 0 0 1 1 1 0 Protein family FAM199X Shisa PF13908.6 EDN06113.1 - 8.2 6.6 9.0 12 6.1 9.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator RRM_1 PF00076.22 EDN06114.1 - 1.4e-07 31.2 0.0 5.4e-05 22.9 0.0 3.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sds3 PF08598.11 EDN06116.1 - 0.00021 21.4 1.0 0.00043 20.3 1.1 1.7 1 1 0 1 1 1 1 Sds3-like DDE_1 PF03184.19 EDN06117.1 - 7.7e-30 103.8 0.0 3.1e-29 101.8 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06117.1 - 1.4e-07 31.4 0.0 3.5e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN06117.1 - 0.002 17.9 0.0 0.0049 16.6 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Coiled-coil_56 PF09813.9 EDN06120.1 - 0.0014 18.6 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 DUF3453 PF11935.8 EDN06121.1 - 6.5e-75 251.6 2.9 1.2e-74 250.8 2.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) TAF6_C PF07571.13 EDN06121.1 - 0.08 13.3 0.0 0.64 10.4 0.0 2.5 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain DUF3194 PF11419.8 EDN06121.1 - 0.13 12.7 0.1 0.44 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3194) TPR_10 PF13374.6 EDN06122.1 - 4.6e-15 54.9 0.1 7.3e-05 22.5 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDN06122.1 - 6.2e-15 55.3 0.1 2.2e-05 24.7 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDN06122.1 - 3.4e-05 23.6 0.7 3.4 8.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDN06122.1 - 0.00017 21.3 3.0 1 9.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN06122.1 - 0.0021 18.1 2.2 1.4 9.3 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN06122.1 - 0.0038 16.7 0.1 0.061 12.7 0.0 2.2 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 EDN06122.1 - 0.037 14.1 0.2 18 5.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDN06122.1 - 0.057 13.8 0.4 11 6.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDN06122.1 - 0.057 14.1 0.3 1.8 9.4 0.0 2.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN06122.1 - 0.09 13.5 0.8 0.44 11.3 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDN06122.1 - 0.094 13.2 0.2 6.6 7.3 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDN06122.1 - 0.18 12.5 0.3 37 5.1 0.1 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat STT3 PF02516.14 EDN06123.1 - 6.1e-129 431.1 33.6 2.5e-124 415.9 31.8 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit ATP-synt_E PF05680.12 EDN06124.1 - 1.5e-24 86.2 0.1 1.6e-24 86.1 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain Adhesin_P1_N PF18652.1 EDN06124.1 - 0.022 14.7 1.7 0.041 13.9 1.7 1.5 1 1 0 1 1 1 0 Adhesin P1 N-terminal domain WD40 PF00400.32 EDN06125.1 - 0.0015 19.3 10.4 3.7 8.6 0.0 5.3 6 1 0 6 6 6 2 WD domain, G-beta repeat Dynein_IC2 PF11540.8 EDN06125.1 - 0.19 11.7 1.5 0.28 11.2 0.3 1.9 2 0 0 2 2 2 0 Cytoplasmic dynein 1 intermediate chain 2 MFS_1 PF07690.16 EDN06126.1 - 6.5e-25 87.8 16.6 6.5e-25 87.8 16.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Asp PF00026.23 EDN06126.1 - 0.1 12.0 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic aspartyl protease WRNPLPNID PF15017.6 EDN06127.1 - 0.39 11.6 2.6 1.3 10.0 2.6 1.8 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box PMT PF02366.18 EDN06128.1 - 8.7e-84 280.9 14.7 1.7e-83 280.0 14.7 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDN06128.1 - 9.1e-67 224.5 0.8 9.1e-67 224.5 0.8 2.9 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDN06128.1 - 9.5e-19 68.0 0.7 1.7e-18 67.1 0.7 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 EDN06128.1 - 0.001 19.3 7.7 0.001 19.3 7.7 3.1 4 1 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase 7TM_GPCR_Str PF10326.9 EDN06128.1 - 0.023 14.0 0.1 0.053 12.9 0.1 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str Pirin PF02678.16 EDN06129.1 - 1.5e-30 105.4 0.2 2.6e-30 104.6 0.2 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EDN06129.1 - 9.7e-21 74.1 0.0 8.1e-20 71.1 0.0 2.4 2 1 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EDN06129.1 - 2.7e-05 23.8 0.9 0.00048 19.8 1.7 2.3 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 EDN06129.1 - 0.087 12.5 0.7 1.3 8.8 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF861) SHD1 PF03983.12 EDN06130.1 - 3.7e-33 113.2 0.0 6.5e-33 112.4 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 EDN06130.1 - 4.1e-33 112.7 5.7 4.4e-14 51.8 0.1 3.4 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 EDN06130.1 - 2.8e-28 97.5 8.4 4.1e-12 45.8 0.4 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 EDN06130.1 - 7.2e-18 64.0 0.1 1.1e-07 31.4 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_10 PF17902.1 EDN06130.1 - 0.00011 22.2 0.1 0.13 12.3 0.0 3.3 3 0 0 3 3 3 1 SH3 domain SH3_3 PF08239.11 EDN06130.1 - 0.065 13.5 5.3 0.073 13.4 0.4 2.9 3 0 0 3 3 3 0 Bacterial SH3 domain TT_ORF2 PF02957.15 EDN06131.1 - 0.94 10.4 3.5 1.8 9.5 3.5 1.4 1 0 0 1 1 1 0 TT viral ORF2 HSCB_C PF07743.13 EDN06132.1 - 6.6e-21 74.6 2.2 7.1e-20 71.3 0.8 2.2 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EDN06132.1 - 2.4e-05 24.4 0.1 6.4e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain F-box PF00646.33 EDN06133.1 - 1.9e-06 27.6 0.9 4.5e-06 26.4 0.9 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN06133.1 - 4e-05 23.4 0.2 9.2e-05 22.3 0.2 1.6 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EDN06133.1 - 0.031 14.6 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 PRANC domain DUF386 PF04074.12 EDN06134.1 - 0.038 13.9 0.1 0.048 13.6 0.1 1.2 1 0 0 1 1 1 0 YhcH/YjgK/YiaL PRP4 PF08799.11 EDN06135.1 - 1.3e-14 53.4 3.2 1.3e-14 53.4 3.2 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Nop53 PF07767.11 EDN06135.1 - 0.15 11.4 6.6 0.22 10.9 6.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PRTP PF01366.18 EDN06135.1 - 0.16 10.0 0.2 0.22 9.5 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Uso1_p115_C PF04871.13 EDN06135.1 - 2.5 8.5 15.8 4.7 7.6 12.7 2.5 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region ERG4_ERG24 PF01222.17 EDN06136.1 - 3.8e-91 306.0 12.8 4.4e-91 305.8 12.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EDN06136.1 - 0.0002 20.9 0.2 0.0002 20.9 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) rve PF00665.26 EDN06137.1 - 1.3e-15 57.6 0.0 2.5e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN06137.1 - 3.7e-14 52.4 1.5 8.2e-14 51.3 1.5 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RT_RNaseH_2 PF17919.1 EDN06137.1 - 2.7e-12 46.6 0.0 2.8e-08 33.7 0.0 2.5 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06137.1 - 2.2e-07 30.9 6.1 5.4e-06 26.4 6.1 2.6 1 1 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 EDN06137.1 - 2.4e-05 24.5 0.0 5.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Mtf2_C PF14061.6 EDN06137.1 - 0.014 15.5 0.9 0.16 12.2 0.2 2.3 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 PSII_Pbs27 PF13326.6 EDN06137.1 - 0.11 12.9 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Photosystem II Pbs27 TackOD1 PF18551.1 EDN06138.1 - 1 9.0 4.5 1.6 8.4 4.5 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 PQ-loop PF04193.14 EDN06139.1 - 9.4e-06 25.3 0.8 3.3e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 PQ loop repeat SpoIIE PF07228.12 EDN06140.1 - 6.4e-06 26.2 0.0 8.6e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EDN06140.1 - 2.3e-05 24.2 0.2 0.21 11.2 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EDN06140.1 - 0.002 17.8 0.0 0.0039 16.9 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C GMC_oxred_N PF00732.19 EDN06142.1 - 7.2e-07 28.9 0.0 0.0075 15.7 0.0 2.1 2 0 0 2 2 2 2 GMC oxidoreductase Pyr_redox_2 PF07992.14 EDN06142.1 - 1.8e-05 24.1 0.0 2.3e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN06142.1 - 8.2e-05 22.8 0.0 0.00049 20.3 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EDN06142.1 - 0.0013 17.8 0.0 0.0018 17.4 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EDN06142.1 - 0.0054 15.9 0.0 0.0074 15.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EDN06142.1 - 0.014 14.6 0.1 0.021 14.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EDN06142.1 - 0.21 10.2 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein GMC_oxred_C PF05199.13 EDN06143.1 - 2.9e-13 50.6 0.0 3.2e-13 50.4 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase DUF5634 PF18681.1 EDN06144.1 - 0.06 13.7 0.0 0.06 13.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5634) PWWP PF00855.17 EDN06145.1 - 3.3e-14 53.0 1.9 3.3e-14 53.0 1.9 2.9 2 1 0 2 2 2 1 PWWP domain Rad60-SLD PF11976.8 EDN06145.1 - 0.11 12.4 0.2 0.33 10.8 0.2 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RTC PF01137.21 EDN06146.1 - 1.4e-14 53.9 0.1 1.9e-14 53.4 0.1 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EDN06146.1 - 9.2e-07 29.3 0.0 1.6e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DDE_1 PF03184.19 EDN06147.1 - 3.5e-18 65.9 0.0 7.9e-16 58.2 0.0 2.9 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06147.1 - 1.6e-07 31.2 0.0 5.4e-07 29.5 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN06147.1 - 6.3e-07 29.0 0.0 1.2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-C2H2_10 PF16588.5 EDN06147.1 - 0.0014 18.3 9.8 0.003 17.3 1.7 2.4 2 0 0 2 2 2 2 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EDN06147.1 - 0.027 14.3 0.4 0.28 11.1 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.6 EDN06147.1 - 0.028 14.2 0.1 0.32 10.7 0.1 2.3 2 0 0 2 2 2 0 DDE superfamily endonuclease zf-CCHC_4 PF14392.6 EDN06147.1 - 0.086 12.6 0.5 0.086 12.6 0.5 1.9 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EDN06147.1 - 0.15 12.2 1.4 0.27 11.4 1.4 1.5 1 0 0 1 1 1 0 Zinc knuckle 3-HAO PF06052.12 EDN06148.1 - 3e-54 182.7 0.0 3.7e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EDN06148.1 - 0.00016 21.4 0.0 0.00027 20.6 0.0 1.5 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EDN06148.1 - 0.0014 18.3 0.1 0.0019 17.8 0.1 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EDN06148.1 - 0.043 13.7 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain TF_Zn_Ribbon PF08271.12 EDN06148.1 - 5.5 6.6 6.4 7.1 6.2 0.9 2.6 1 1 1 2 2 2 0 TFIIB zinc-binding CAP_GLY PF01302.25 EDN06149.1 - 1.1e-15 57.3 0.4 3.2e-15 55.9 0.4 1.8 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EDN06149.1 - 1.1e-05 25.2 16.6 5.2e-05 23.0 0.9 3.1 3 0 0 3 3 3 2 CLIP1 zinc knuckle Fez1 PF06818.15 EDN06149.1 - 0.0011 19.5 24.6 0.57 10.6 20.4 3.2 2 1 1 3 3 3 2 Fez1 DUF1664 PF07889.12 EDN06149.1 - 0.019 15.0 11.4 0.11 12.6 1.8 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EDN06149.1 - 0.027 13.4 25.2 0.022 13.6 11.4 3.1 2 1 1 3 3 3 0 Spc7 kinetochore protein SHE3 PF17078.5 EDN06149.1 - 0.037 13.7 13.0 0.24 11.1 0.5 2.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 ATG16 PF08614.11 EDN06149.1 - 0.053 13.7 39.5 0.028 14.7 8.1 3.8 3 1 1 4 4 3 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 EDN06149.1 - 0.062 13.3 29.5 2.9 7.9 1.4 5.4 4 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.9 EDN06149.1 - 0.12 12.7 14.0 0.75 10.1 1.8 4.1 4 1 0 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Peptidase_S46 PF10459.9 EDN06149.1 - 0.14 10.8 8.2 0.22 10.1 8.2 1.2 1 0 0 1 1 1 0 Peptidase S46 DUF3584 PF12128.8 EDN06149.1 - 0.23 8.9 19.0 0.35 8.3 19.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) EzrA PF06160.12 EDN06149.1 - 0.32 9.1 18.7 0.13 10.4 0.8 2.8 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA FliS PF02561.14 EDN06149.1 - 0.37 11.1 2.8 0.78 10.0 0.5 2.4 2 1 2 4 4 4 0 Flagellar protein FliS Spc29 PF17082.5 EDN06149.1 - 0.54 10.1 17.6 0.22 11.3 2.0 3.4 1 1 1 3 3 3 0 Spindle Pole Component 29 C1_2 PF03107.16 EDN06149.1 - 0.77 10.1 2.9 16 5.9 0.1 2.4 2 0 0 2 2 2 0 C1 domain Laminin_II PF06009.12 EDN06149.1 - 0.79 9.7 10.6 0.042 13.9 0.6 2.9 2 1 1 3 3 3 0 Laminin Domain II Fib_alpha PF08702.10 EDN06149.1 - 0.97 9.6 9.1 34 4.6 0.2 3.6 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.6 EDN06149.1 - 1 7.9 15.7 0.54 8.8 10.4 2.3 2 1 0 2 2 2 0 AAA domain SlyX PF04102.12 EDN06149.1 - 1.1 9.9 27.3 1.7 9.3 0.5 4.5 4 0 0 4 4 4 0 SlyX DUF812 PF05667.11 EDN06149.1 - 1.7 7.5 23.5 0.089 11.7 13.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF641 PF04859.12 EDN06149.1 - 2 8.7 18.6 1.5 9.2 0.2 4.3 2 1 2 4 4 4 0 Plant protein of unknown function (DUF641) FlaC_arch PF05377.11 EDN06149.1 - 2.1 8.8 11.3 19 5.8 0.3 3.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) zf_PR_Knuckle PF18445.1 EDN06149.1 - 4.4 7.2 4.7 12 5.8 0.5 2.4 2 0 0 2 2 2 0 PR zinc knuckle motif Lebercilin PF15619.6 EDN06149.1 - 7.6 6.1 31.7 0.23 11.1 1.4 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 EDN06149.1 - 8.3 6.9 9.5 27 5.3 0.3 3.7 2 1 2 4 4 3 0 Nucleopolyhedrovirus P10 protein Pox_A_type_inc PF04508.12 EDN06149.1 - 8.8 6.4 14.9 2.1 8.3 0.2 4.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat PspA_IM30 PF04012.12 EDN06149.1 - 8.9 5.8 27.1 55 3.2 0.2 3.3 2 1 1 3 3 3 0 PspA/IM30 family Sec2p PF06428.11 EDN06149.1 - 9.1 6.3 20.7 2.6 8.1 1.9 4.2 3 2 1 4 4 4 0 GDP/GTP exchange factor Sec2p Pkinase PF00069.25 EDN06150.1 - 1.6e-24 86.7 0.0 2.1e-18 66.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06150.1 - 4.1e-07 29.5 0.0 0.0004 19.8 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EDN06150.1 - 0.00015 21.2 0.0 0.36 10.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like FXR_C1 PF16096.5 EDN06150.1 - 0.045 14.0 0.7 0.087 13.0 0.7 1.4 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 APH PF01636.23 EDN06150.1 - 0.06 13.3 0.2 0.14 12.1 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S9 PF00326.21 EDN06151.1 - 1.3e-52 178.3 0.1 1.9e-52 177.9 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EDN06151.1 - 5.8e-06 26.1 0.7 9.6e-06 25.4 0.7 1.3 1 0 0 1 1 1 1 Putative esterase AXE1 PF05448.12 EDN06151.1 - 1.2e-05 24.1 0.3 0.0011 17.8 0.3 2.1 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 EDN06151.1 - 0.00013 21.7 0.7 0.00043 20.0 0.2 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Macro_2 PF14519.6 EDN06151.1 - 0.072 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Macro-like domain DUF3189 PF11385.8 EDN06151.1 - 0.087 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) Sec63 PF02889.16 EDN06152.1 - 1.4e-64 217.7 5.4 4.7e-53 180.0 0.2 4.1 2 2 1 3 3 3 3 Sec63 Brl domain DEAD PF00270.29 EDN06152.1 - 1.8e-50 171.1 0.3 3.3e-28 98.6 0.0 3.8 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 EDN06152.1 - 1.5e-25 90.1 0.0 7.1e-15 55.4 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDN06152.1 - 1.3e-11 44.8 0.0 2.1e-07 31.2 0.0 3.7 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDN06152.1 - 2e-08 34.6 0.4 0.0027 18.0 0.0 4.2 3 2 0 3 3 3 2 AAA domain T2SSE PF00437.20 EDN06152.1 - 0.0012 18.0 0.0 0.33 10.0 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_30 PF13604.6 EDN06152.1 - 0.0013 18.5 0.0 1.5 8.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EDN06152.1 - 0.011 15.2 0.0 0.84 9.0 0.0 2.7 3 0 0 3 3 3 0 PhoH-like protein AAA_19 PF13245.6 EDN06152.1 - 0.017 15.5 0.3 7.3 6.9 0.3 3.1 2 1 0 2 2 2 0 AAA domain MutS_I PF01624.20 EDN06153.1 - 3.3e-22 78.8 0.0 5.4e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EDN06153.1 - 5.2e-08 33.3 0.1 8.6e-08 32.5 0.1 1.4 1 0 0 1 1 1 1 MutS domain II Ureidogly_lyase PF04115.12 EDN06154.1 - 3.4e-16 59.6 0.0 4.6e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Ureidoglycolate lyase ADH_N_2 PF16884.5 EDN06155.1 - 6.7e-06 26.0 0.1 1.2e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_N PF08240.12 EDN06155.1 - 1.5e-05 24.8 0.5 1.5e-05 24.8 0.5 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Tim17 PF02466.19 EDN06156.1 - 3e-13 50.1 1.1 5.2e-13 49.3 1.1 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF5518 PF17647.1 EDN06156.1 - 0.28 11.3 4.0 11 6.2 0.1 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5518) HTH_Tnp_Tc3_2 PF01498.18 EDN06157.1 - 5.5e-06 26.5 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.6 EDN06157.1 - 5.2e-05 23.3 0.3 0.00016 21.7 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 EDN06157.1 - 0.00012 22.6 0.3 0.007 17.0 0.0 2.4 1 1 1 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN06157.1 - 0.0011 18.5 0.0 0.0022 17.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 EDN06157.1 - 0.0014 18.3 0.8 0.0035 17.1 0.1 2.0 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EDN06157.1 - 0.0048 16.5 0.1 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 EDN06157.1 - 0.069 12.7 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Brix PF04427.18 EDN06158.1 - 5.9e-36 124.4 0.0 8e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain RNase_P_p30 PF01876.16 EDN06159.1 - 1.7e-67 227.1 0.0 2.2e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 Pkinase PF00069.25 EDN06160.1 - 9.1e-63 212.1 0.0 1.1e-62 211.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06160.1 - 1.6e-17 63.7 0.0 2.2e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN06160.1 - 3.8e-07 30.3 0.0 0.00012 22.1 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN06160.1 - 0.0054 15.6 0.0 0.0086 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDN06160.1 - 0.035 13.4 0.0 0.065 12.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EDN06160.1 - 0.04 13.5 1.0 0.072 12.7 0.1 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 EDN06160.1 - 0.053 12.9 0.5 0.1 11.9 0.5 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family tRNA-synt_1 PF00133.22 EDN06161.1 - 1.5e-168 561.8 2.9 5.7e-133 444.3 0.2 3.1 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDN06161.1 - 1.8e-12 46.7 0.4 5.9e-05 22.0 0.0 3.2 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDN06161.1 - 1.1e-05 25.0 1.3 0.0002 21.0 0.0 2.5 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDN06161.1 - 0.0012 18.2 0.0 0.041 13.2 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EDN06161.1 - 0.061 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Kri1 PF05178.12 EDN06161.1 - 0.91 10.1 6.9 1.9 9.1 6.9 1.5 1 0 0 1 1 1 0 KRI1-like family T2SSJ PF11612.8 EDN06164.1 - 0.0092 16.2 0.7 0.014 15.6 0.2 1.5 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein J SUIM_assoc PF16619.5 EDN06164.1 - 0.014 15.5 10.7 0.14 12.3 2.6 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 ydhR PF08803.11 EDN06164.1 - 0.14 12.1 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Putative mono-oxygenase ydhR RCDG1 PF15725.5 EDN06164.1 - 0.19 12.2 4.4 0.11 12.9 2.3 1.7 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein DUF3597 PF12200.8 EDN06164.1 - 0.41 11.2 4.4 7.9 7.0 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) TFIIA PF03153.13 EDN06164.1 - 0.94 9.4 9.4 1.1 9.1 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HMG-CoA_red PF00368.18 EDN06165.1 - 0.31 10.0 6.7 0.06 12.3 2.9 1.6 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A reductase SelP_N PF04592.14 EDN06165.1 - 3 7.2 8.4 4.5 6.6 8.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3431 PF11913.8 EDN06166.1 - 8.4e-90 300.3 0.1 1.1e-89 299.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DASH_Hsk3 PF08227.11 EDN06167.1 - 0.61 10.5 7.3 1.3 9.4 7.3 1.5 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like TFIIA PF03153.13 EDN06167.1 - 0.94 9.4 12.3 1.8 8.5 12.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.16 EDN06168.1 - 2.3e-07 30.1 30.4 2.8e-06 26.5 9.3 3.9 4 1 0 4 4 4 3 Major Facilitator Superfamily Myb_DNA-bind_4 PF13837.6 EDN06169.1 - 0.044 14.2 0.3 0.044 14.2 0.3 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain ATP_transf PF09830.9 EDN06170.1 - 5.1e-23 81.0 0.0 9.1e-23 80.2 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 EDN06170.1 - 0.036 13.4 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4931) zf-C2H2 PF00096.26 EDN06171.1 - 0.00094 19.5 18.5 0.6 10.7 1.1 4.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type TEX19 PF15553.6 EDN06171.1 - 0.092 12.7 1.5 11 5.9 0.0 2.6 2 0 0 2 2 2 0 Testis-expressed protein 19 DUF4451 PF14616.6 EDN06171.1 - 0.16 12.2 6.1 0.07 13.3 2.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4451) zf-C2H2_4 PF13894.6 EDN06171.1 - 1.7 9.7 19.6 0.89 10.6 0.7 5.1 4 1 0 4 4 4 0 C2H2-type zinc finger RPN7 PF10602.9 EDN06172.1 - 2.3e-39 134.9 0.0 3.8e-39 134.2 0.0 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EDN06172.1 - 3.2e-10 40.4 0.1 1.7e-09 38.1 0.0 2.2 2 0 0 2 2 2 1 PCI domain DSBA PF01323.20 EDN06173.1 - 1.2e-06 28.5 0.0 1.7e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 EDN06174.1 - 5.6e-26 91.2 0.1 6.9e-26 90.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN06174.1 - 1.2e-21 77.4 0.1 1.5e-21 77.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 EDN06174.1 - 0.19 11.5 0.5 3.2 7.6 0.7 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase LtrA PF06772.11 EDN06175.1 - 2.3e-06 27.1 34.4 6.5e-06 25.6 10.7 3.2 3 0 0 3 3 3 2 Bacterial low temperature requirement A protein (LtrA) PCNA_N PF00705.18 EDN06175.1 - 0.16 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain FUSC PF04632.12 EDN06176.1 - 1.7 7.1 3.4 2.2 6.7 3.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family LSM PF01423.22 EDN06177.1 - 9.3e-22 76.5 0.9 1e-21 76.4 0.9 1.0 1 0 0 1 1 1 1 LSM domain Peptidase_M1 PF01433.20 EDN06178.1 - 0.015 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDN06178.1 - 0.13 12.4 0.1 15 5.7 0.0 2.7 3 0 0 3 3 3 0 Peptidase M1 N-terminal domain VGCC_beta4Aa_N PF12052.8 EDN06178.1 - 3.8 7.7 6.2 51 4.1 0.1 3.0 2 0 0 2 2 2 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal CDP-OH_P_transf PF01066.21 EDN06179.1 - 3.7e-14 53.2 0.1 3.7e-14 53.2 0.1 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF3659 PF12396.8 EDN06181.1 - 2.9e-16 59.1 7.9 4.9e-16 58.4 7.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3659) AAA_PrkA PF08298.11 EDN06181.1 - 0.1 11.5 0.0 0.29 10.0 0.0 1.6 2 0 0 2 2 2 0 PrkA AAA domain DUF3659 PF12396.8 EDN06182.1 - 7.1e-33 112.3 14.8 4.9e-21 74.4 0.4 3.6 3 1 0 3 3 3 3 Protein of unknown function (DUF3659) LCCL PF03815.19 EDN06183.1 - 4.5e-12 45.9 0.3 6.7e-12 45.4 0.3 1.2 1 0 0 1 1 1 1 LCCL domain Tli4_C PF18426.1 EDN06185.1 - 0.12 12.7 2.3 0.35 11.2 2.3 1.9 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain DUF3435 PF11917.8 EDN06187.1 - 3.9e-59 200.7 0.1 4.9e-42 144.3 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) PX PF00787.24 EDN06189.1 - 2.2e-06 27.6 0.0 4.5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 PX domain PX PF00787.24 EDN06191.1 - 7.2e-15 55.0 0.0 1.3e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 PX domain SAS4 PF15460.6 EDN06192.1 - 3.6e-34 116.8 6.7 7.6e-34 115.8 6.7 1.6 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 NOA36 PF06524.12 EDN06192.1 - 7.6 5.7 9.0 13 5.0 9.0 1.3 1 0 0 1 1 1 0 NOA36 protein HVSL PF09749.9 EDN06193.1 - 4.8e-73 245.5 0.0 6.7e-72 241.8 0.0 2.0 1 1 0 1 1 1 1 Uncharacterised conserved protein Pal1 PF08316.11 EDN06194.1 - 1.2e-07 32.6 0.5 2e-07 31.8 0.5 1.4 1 0 0 1 1 1 1 Pal1 cell morphology protein UPF0047 PF01894.17 EDN06194.1 - 0.16 12.1 1.0 0.29 11.3 0.5 1.7 1 1 0 1 1 1 0 Uncharacterised protein family UPF0047 Methyltransf_28 PF02636.17 EDN06195.1 - 1e-42 146.6 0.0 1.4e-42 146.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 EDN06195.1 - 0.042 13.7 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase RrnaAD PF00398.20 EDN06195.1 - 0.054 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PALP PF00291.25 EDN06196.1 - 1.2e-51 175.9 0.1 1.5e-51 175.5 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Scm3 PF10384.9 EDN06197.1 - 6.4e-22 77.0 0.1 1.2e-21 76.1 0.1 1.5 1 0 0 1 1 1 1 Centromere protein Scm3 Myb_DNA-binding PF00249.31 EDN06197.1 - 3.3e-05 24.0 0.0 0.0035 17.5 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain APG6 PF04111.12 EDN06198.1 - 5.4e-74 248.0 0.0 7.8e-74 247.5 0.0 1.2 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EDN06198.1 - 1.1e-39 136.1 14.1 1.6e-39 135.5 14.1 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF4197 PF13852.6 EDN06198.1 - 0.091 12.4 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4197) Rpr2 PF04032.16 EDN06198.1 - 0.15 12.4 0.5 0.56 10.5 0.0 2.2 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Jnk-SapK_ap_N PF09744.9 EDN06198.1 - 8.8 6.5 12.7 19 5.5 12.3 1.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Peroxin-13_N PF04088.13 EDN06200.1 - 3.5e-53 179.8 0.0 5.1e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EDN06200.1 - 5.3e-09 35.6 0.0 9.8e-09 34.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDN06200.1 - 2.2e-06 27.2 0.0 3.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN06200.1 - 3.6e-05 23.5 0.1 5.8e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain ERO1 PF04137.15 EDN06201.1 - 1.8e-132 441.9 0.0 2.5e-132 441.4 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) TPP_enzyme_N PF02776.18 EDN06202.1 - 1.2e-44 152.0 0.1 2.3e-44 151.0 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDN06202.1 - 4.4e-37 126.9 0.0 9.3e-37 125.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDN06202.1 - 1.1e-16 61.0 0.0 4.5e-16 59.0 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PaO PF08417.12 EDN06202.1 - 0.037 14.2 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Pheophorbide a oxygenase TPR_1 PF00515.28 EDN06203.1 - 3e-26 90.1 2.8 2e-09 36.9 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDN06203.1 - 4.3e-25 85.8 3.5 1e-07 31.5 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN06203.1 - 1.7e-20 72.4 2.7 1.3e-08 34.3 0.1 5.2 4 2 1 5 5 5 3 TPR repeat TPR_14 PF13428.6 EDN06203.1 - 1.1e-17 63.2 3.3 2.5e-05 24.7 0.0 5.5 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDN06203.1 - 4.2e-17 62.5 1.7 1.2e-05 25.8 0.0 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDN06203.1 - 1.6e-16 59.1 1.9 5.2e-07 29.4 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDN06203.1 - 1.5e-15 56.3 3.2 0.002 18.4 0.1 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 EDN06203.1 - 5e-15 55.8 4.7 0.0002 21.8 0.0 4.4 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDN06203.1 - 1.2e-11 43.8 0.9 0.0051 16.8 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 EDN06203.1 - 5.1e-11 42.8 0.6 0.0032 17.8 0.1 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN06203.1 - 9.8e-11 41.8 4.2 2.1e-05 24.7 0.4 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDN06203.1 - 9.8e-11 41.7 1.7 0.003 17.7 0.0 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDN06203.1 - 3.4e-08 33.6 1.5 1.8 9.4 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN06203.1 - 1.1e-06 28.8 0.9 0.0028 17.9 0.1 2.8 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EDN06203.1 - 0.0002 20.7 1.4 0.23 10.7 0.4 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDN06203.1 - 0.0025 17.7 3.2 0.061 13.2 0.3 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 EDN06203.1 - 0.0028 17.7 0.2 7.1 6.8 0.0 4.2 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 EDN06203.1 - 0.014 15.3 0.3 3 7.9 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TOM20_plant PF06552.12 EDN06203.1 - 0.041 13.6 0.0 4 7.1 0.0 2.9 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 DUF1641 PF07849.11 EDN06203.1 - 0.088 12.7 0.2 0.18 11.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) BTAD PF03704.17 EDN06203.1 - 0.1 13.0 3.2 8.7 6.8 0.1 3.1 4 0 0 4 4 3 0 Bacterial transcriptional activator domain RRM_1 PF00076.22 EDN06204.1 - 1.5e-23 82.4 0.1 1.7e-14 53.3 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.18 EDN06205.1 - 2.5e-09 36.6 0.0 4.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CAP_N PF01213.19 EDN06205.1 - 2.4 7.6 7.4 11 5.4 0.2 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal RNA_pol_Rbc25 PF08292.12 EDN06207.1 - 0.044 14.0 3.1 0.082 13.2 0.2 2.9 2 1 1 3 3 3 0 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EDN06208.1 - 2.1e-14 53.6 0.1 3.2e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EDN06208.1 - 1.4e-11 44.5 0.0 2.2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 EDN06208.1 - 0.033 14.4 0.0 0.057 13.7 0.0 1.5 1 1 0 1 1 1 0 RNA polymerase III subunit Rpc25 DUF962 PF06127.11 EDN06209.1 - 1e-16 60.8 9.9 4e-15 55.7 9.9 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF962) ATP-synt_ab PF00006.25 EDN06210.1 - 7.2e-61 205.5 0.0 1.1e-60 204.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EDN06210.1 - 1.1e-48 164.7 2.3 1.7e-48 164.1 2.3 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain Tex_N PF09371.10 EDN06210.1 - 0.014 15.1 0.1 0.035 13.8 0.1 1.6 1 0 0 1 1 1 0 Tex-like protein N-terminal domain THF_DHG_CYH PF00763.23 EDN06211.1 - 1.6e-23 83.1 0.0 2.5e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EDN06211.1 - 4.8e-12 45.5 0.1 5.9e-09 35.4 0.0 2.3 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SPC25 PF06703.11 EDN06212.1 - 1.1e-46 158.6 0.0 1.2e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) EMC3_TMCO1 PF01956.16 EDN06213.1 - 1.2e-53 181.4 0.1 1.6e-53 181.0 0.1 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Fasciclin PF02469.22 EDN06214.1 - 0.00034 20.9 0.0 0.00053 20.2 0.0 1.3 1 1 0 1 1 1 1 Fasciclin domain AGH PF17558.2 EDN06214.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Androgenic gland hormone MMS19_C PF12460.8 EDN06215.1 - 1.1e-43 150.0 7.1 1.9e-42 145.9 0.0 3.4 3 1 1 4 4 4 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EDN06215.1 - 1.1e-41 143.1 0.7 1.7e-29 103.2 0.0 3.9 4 1 0 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 EDN06215.1 - 0.0015 18.9 0.6 3.7 8.0 0.0 3.5 4 0 0 4 4 4 2 HEAT repeats RTP1_C1 PF10363.9 EDN06215.1 - 0.021 15.0 0.0 0.23 11.7 0.0 2.7 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EDN06215.1 - 0.029 14.6 0.0 19 5.8 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat RFC1 PF08519.12 EDN06215.1 - 0.12 12.5 1.4 0.57 10.3 0.1 2.8 4 0 0 4 4 4 0 Replication factor RFC1 C terminal domain MMS19_C PF12460.8 EDN06216.1 - 7.2e-14 51.7 1.4 9.2e-14 51.4 1.0 1.4 2 0 0 2 2 2 1 RNAPII transcription regulator C-terminal HEAT PF02985.22 EDN06216.1 - 0.035 14.4 2.4 9.8 6.7 0.1 3.4 3 0 0 3 3 3 0 HEAT repeat TPP1 PF10341.9 EDN06217.1 - 0.046 13.7 0.1 1.6 8.7 0.0 2.8 2 0 0 2 2 2 0 Shelterin complex subunit, TPP1/ACD FXMR_C2 PF16098.5 EDN06217.1 - 0.066 13.7 3.7 0.21 12.1 0.4 2.6 2 0 0 2 2 2 0 Fragile X-related mental retardation protein C-terminal region 2 TTSSLRR PF12468.8 EDN06217.1 - 0.13 12.5 0.1 0.78 10.0 0.0 2.4 2 0 0 2 2 2 0 Type III secretion system leucine rich repeat protein SHE3 PF17078.5 EDN06218.1 - 7.9 6.1 23.4 0.25 11.0 16.6 1.8 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 adh_short PF00106.25 EDN06221.1 - 1.6e-20 73.4 2.9 2.5e-18 66.3 1.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDN06221.1 - 8.6e-10 38.8 0.2 1.5e-09 38.1 0.2 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDN06221.1 - 0.00062 19.0 0.1 0.00085 18.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF3842 PF12953.7 EDN06221.1 - 0.03 14.7 0.4 0.059 13.7 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) Shikimate_DH PF01488.20 EDN06221.1 - 0.051 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 EDN06222.1 - 2.3e-60 203.9 0.0 4e-60 203.1 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EDN06222.1 - 2.1e-51 174.2 1.4 3.1e-51 173.6 0.6 1.7 2 0 0 2 2 2 1 short chain dehydrogenase AMP-binding PF00501.28 EDN06222.1 - 3.8e-43 147.7 0.0 1.7e-24 86.2 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme adh_short_C2 PF13561.6 EDN06222.1 - 3.7e-38 131.4 0.1 4.8e-37 127.8 0.3 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN06222.1 - 2.9e-16 59.9 0.8 3.7e-12 46.5 0.4 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EDN06222.1 - 4.3e-14 52.6 0.0 1.1e-09 38.2 0.0 2.9 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN06222.1 - 6.5e-09 35.2 0.0 5.3e-06 25.7 0.0 3.0 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EDN06222.1 - 1.6e-06 27.4 0.2 0.0022 17.1 0.0 3.0 2 1 0 2 2 2 2 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDN06222.1 - 1e-05 24.8 0.2 0.069 12.3 0.0 3.3 3 0 0 3 3 3 2 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EDN06222.1 - 0.015 15.2 0.3 0.73 9.7 0.1 2.9 3 0 0 3 3 3 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EDN06222.1 - 0.041 13.3 0.1 3.2 7.1 0.0 2.3 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ApbA PF02558.16 EDN06222.1 - 0.045 13.4 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DFP PF04127.15 EDN06222.1 - 0.059 13.2 0.6 0.23 11.3 0.7 1.8 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein CBF PF03914.17 EDN06224.1 - 5e-39 134.1 1.1 7e-39 133.6 0.2 1.7 2 0 0 2 2 2 1 CBF/Mak21 family Mt_ATP-synt_B PF05405.14 EDN06225.1 - 2.5e-51 173.6 12.1 3e-51 173.3 12.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SLATT_1 PF18181.1 EDN06225.1 - 0.0069 16.3 2.2 0.019 14.9 2.0 1.8 1 1 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 1 Med2 PF11214.8 EDN06225.1 - 0.16 12.2 0.3 0.16 12.2 0.3 2.3 1 1 1 2 2 2 0 Mediator complex subunit 2 Spore_III_AB PF09548.10 EDN06225.1 - 0.21 11.7 3.6 0.4 10.8 3.6 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) RGS PF00615.19 EDN06225.1 - 1.4 9.2 5.0 2.9 8.2 2.5 2.1 1 1 1 2 2 2 0 Regulator of G protein signaling domain Pkinase PF00069.25 EDN06226.1 - 7.2e-09 35.4 0.0 2.6e-08 33.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06226.1 - 1.2e-08 34.6 0.0 4.5e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.12 EDN06227.1 - 1.3e-14 54.3 10.8 1.4e-06 28.8 0.2 3.4 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.6 EDN06227.1 - 0.29 11.9 1.8 21 6.0 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat SPX PF03105.19 EDN06227.1 - 0.29 11.0 13.4 0.58 10.0 13.4 1.5 1 0 0 1 1 1 0 SPX domain TFIIF_beta PF02270.15 EDN06230.1 - 7.3e-29 99.7 0.3 1.2e-28 99.0 0.3 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EDN06230.1 - 1.6e-24 87.1 1.3 2.9e-24 86.3 1.3 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus Tau95 PF09734.9 EDN06230.1 - 0.0018 19.1 2.2 0.0034 18.2 2.2 1.6 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain DUF1040 PF06288.13 EDN06232.1 - 0.079 13.4 0.6 0.32 11.4 0.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1040) DUF1265 PF06887.14 EDN06232.1 - 0.084 12.9 0.9 3.3 7.7 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1265) RVT_2 PF07727.14 EDN06233.1 - 1.7e-43 149.0 0.0 2.7e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06233.1 - 1.8e-12 47.5 0.1 6e-12 45.8 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN06233.1 - 0.029 14.1 3.0 0.056 13.2 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN06233.1 - 0.031 14.1 0.0 0.084 12.7 0.0 1.7 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN06233.1 - 0.087 12.6 0.1 0.28 11.0 0.1 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_2 PF14223.6 EDN06233.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type CP2 PF04516.15 EDN06234.1 - 9.1e-74 247.6 0.0 1.2e-73 247.2 0.0 1.1 1 0 0 1 1 1 1 CP2 transcription factor DDE_1 PF03184.19 EDN06236.1 - 2.8e-31 108.5 0.0 1.1e-30 106.6 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06236.1 - 1.3e-11 44.4 0.0 5.1e-11 42.5 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN06236.1 - 3.3e-07 29.9 0.1 7.6e-07 28.8 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN06236.1 - 0.0014 18.4 0.0 0.0064 16.3 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease AcetylCoA_hydro PF02550.15 EDN06237.1 - 3.1e-36 125.2 0.0 5e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain DDE_1 PF03184.19 EDN06237.1 - 2.4e-16 59.9 0.0 3.2e-15 56.2 0.0 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease APG5 PF04106.12 EDN06238.1 - 0.018 14.6 0.0 0.02 14.5 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg5 Adeno_terminal PF02459.15 EDN06238.1 - 0.027 12.9 0.2 0.027 12.9 0.2 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DUF3069 PF11269.8 EDN06238.1 - 0.05 13.8 0.2 0.064 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) POP1 PF06978.11 EDN06238.1 - 0.12 12.4 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 Sin3a_C PF16879.5 EDN06239.1 - 7.6e-79 265.4 0.2 3.6e-78 263.2 0.0 2.3 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 EDN06239.1 - 6.1e-43 144.7 2.0 1.5e-17 63.5 0.0 3.6 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EDN06239.1 - 1.7e-40 137.0 0.2 4.3e-40 135.7 0.2 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor Adeno_shaft PF00608.17 EDN06240.1 - 0.028 14.2 0.1 0.058 13.2 0.1 1.5 1 0 0 1 1 1 0 Adenoviral fibre protein (repeat/shaft region) Pyr_redox_3 PF13738.6 EDN06241.1 - 1.4e-24 86.9 0.0 1.8e-23 83.3 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EDN06241.1 - 1.5e-21 76.4 0.0 6.4e-21 74.4 0.0 1.9 1 1 1 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EDN06241.1 - 1.4e-16 60.6 0.0 3.4e-16 59.3 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDN06241.1 - 2.5e-14 53.2 1.8 1.9e-11 43.7 0.1 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EDN06241.1 - 3.9e-10 40.2 0.5 0.027 15.0 0.1 3.4 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDN06241.1 - 7.1e-09 35.4 0.2 6.6e-05 22.3 0.1 2.7 3 0 0 3 3 3 2 FAD binding domain F420_oxidored PF03807.17 EDN06241.1 - 1.6e-05 25.4 0.4 0.007 16.9 0.2 3.2 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent HI0933_like PF03486.14 EDN06241.1 - 2.5e-05 23.2 0.8 0.0025 16.6 0.1 3.2 3 1 1 4 4 4 1 HI0933-like protein ApbA PF02558.16 EDN06241.1 - 5.4e-05 22.9 0.1 0.12 12.0 0.0 2.3 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EDN06241.1 - 9.9e-05 22.3 0.7 0.013 15.4 0.2 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDN06241.1 - 0.00016 21.1 0.2 0.043 13.2 0.1 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 EDN06241.1 - 0.00019 21.2 0.4 0.57 9.7 0.1 2.9 2 1 0 3 3 3 2 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EDN06241.1 - 0.00021 21.4 0.1 0.064 13.3 0.1 2.7 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.6 EDN06241.1 - 0.00033 20.8 0.0 0.0033 17.6 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EDN06241.1 - 0.00072 18.7 0.1 0.27 10.3 0.0 2.8 2 1 1 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.17 EDN06241.1 - 0.00082 18.7 0.6 0.19 10.9 0.0 3.0 4 0 0 4 4 3 1 Thi4 family NAD_binding_9 PF13454.6 EDN06241.1 - 0.0013 18.8 1.9 1.4 8.9 0.0 3.3 2 2 1 3 3 3 2 FAD-NAD(P)-binding IlvN PF07991.12 EDN06241.1 - 0.0025 17.4 1.4 0.0026 17.3 0.3 1.7 2 0 0 2 2 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_Gly3P_dh_N PF01210.23 EDN06241.1 - 0.0038 17.2 0.2 0.054 13.5 0.0 2.3 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 EDN06241.1 - 0.006 16.8 0.1 0.82 9.9 0.0 2.6 2 0 0 2 2 2 1 TrkA-N domain FAD_binding_2 PF00890.24 EDN06241.1 - 0.007 15.5 1.2 0.086 11.9 0.2 2.6 2 1 1 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 EDN06241.1 - 0.0087 15.4 0.0 3.5 6.9 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EDN06241.1 - 0.0092 15.1 0.3 0.16 11.0 0.0 2.5 2 1 0 2 2 2 1 Lycopene cyclase protein NAD_binding_7 PF13241.6 EDN06241.1 - 0.016 15.7 2.0 0.049 14.1 0.2 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding zinc_ribbon_6 PF14599.6 EDN06241.1 - 0.2 11.7 0.0 0.41 10.7 0.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon WD40 PF00400.32 EDN06243.1 - 2.7e-10 40.7 2.0 0.12 13.3 0.2 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat PCI PF01399.27 EDN06244.1 - 7.8e-11 42.4 0.0 3.5e-10 40.3 0.0 2.1 2 0 0 2 2 2 1 PCI domain RPN7 PF10602.9 EDN06244.1 - 3.8e-06 26.7 0.2 6.7e-06 25.9 0.2 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_19 PF14559.6 EDN06244.1 - 0.00049 20.6 0.8 0.36 11.4 0.6 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDN06244.1 - 0.043 14.0 0.0 2 8.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Helicase_C_4 PF13871.6 EDN06244.1 - 0.051 13.2 0.4 0.47 10.1 0.1 2.1 2 0 0 2 2 2 0 C-terminal domain on Strawberry notch homologue SPO22 PF08631.10 EDN06244.1 - 0.069 12.6 1.0 0.2 11.1 0.3 2.1 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 EDN06244.1 - 0.14 13.0 3.5 7 7.8 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat RVT_1 PF00078.27 EDN06245.1 - 6.5e-17 61.8 0.0 1.1e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN06245.1 - 1.7e-11 44.5 0.0 3.4e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 RNase H Pkinase PF00069.25 EDN06248.1 - 1e-05 25.1 0.1 1.3e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN06248.1 - 0.00028 20.3 0.2 0.00044 19.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN06248.1 - 0.039 13.9 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.11 EDN06248.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RVT_2 PF07727.14 EDN06249.1 - 2.2e-23 83.2 0.0 2.2e-11 43.9 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06249.1 - 0.00043 20.5 0.0 0.00099 19.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MFS_1 PF07690.16 EDN06252.1 - 2.7e-45 154.8 55.9 5.4e-45 153.8 54.4 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN06252.1 - 9e-14 50.8 26.2 1.3e-13 50.3 26.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDN06252.1 - 1.3e-13 50.7 7.1 1.3e-13 50.7 7.1 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EDN06252.1 - 0.2 9.9 10.7 0.41 8.9 4.1 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Sel1 PF08238.12 EDN06253.1 - 2.1e-32 110.8 15.6 2.8e-07 31.0 0.0 5.3 5 0 0 5 5 5 5 Sel1 repeat Chitin_synth_2 PF03142.15 EDN06254.1 - 1.7e-289 960.8 1.0 2.2e-289 960.5 1.0 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EDN06254.1 - 8.4e-13 48.7 1.9 2e-12 47.4 1.9 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDN06254.1 - 2e-10 40.9 0.0 4.4e-09 36.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDN06254.1 - 5.5e-05 22.7 0.0 0.00079 18.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDN06254.1 - 0.0013 18.6 0.0 0.084 12.7 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 MFS_1 PF07690.16 EDN06256.1 - 1e-30 106.9 16.7 1.3e-30 106.6 16.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN06256.1 - 1.1e-10 41.0 11.6 1.5e-10 40.5 11.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EDN06256.1 - 1.9e-08 33.2 5.9 2.3e-08 33.0 5.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fasciclin PF02469.22 EDN06257.1 - 3.6e-26 91.9 0.2 8.4e-16 58.4 0.2 2.5 2 1 0 2 2 2 2 Fasciclin domain WD40 PF00400.32 EDN06259.1 - 0.00041 21.1 0.1 0.0016 19.2 0.1 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat NMU PF02070.15 EDN06259.1 - 0.19 11.6 0.4 0.6 10.0 0.4 1.9 1 0 0 1 1 1 0 Neuromedin U Nop14 PF04147.12 EDN06259.1 - 2.1 6.4 5.7 2.8 6.0 5.7 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 EDN06259.1 - 2.6 8.5 23.3 8 6.9 23.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PARP PF00644.20 EDN06260.1 - 2e-60 203.7 2.4 3.9e-60 202.8 0.0 2.3 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EDN06260.1 - 5.2e-42 143.2 0.0 8.3e-42 142.5 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EDN06260.1 - 5.6e-24 84.0 0.3 5.6e-24 84.0 0.3 1.9 2 0 0 2 2 2 1 WGR domain BRCT PF00533.26 EDN06260.1 - 5.7e-07 29.8 0.2 3.2e-06 27.4 0.1 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDN06260.1 - 0.00016 22.0 0.0 0.00039 20.8 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EDN06260.1 - 0.0037 17.2 0.2 0.0092 15.9 0.2 1.7 1 0 0 1 1 1 1 twin BRCT domain Tombus_movement PF05318.12 EDN06260.1 - 8.8 7.2 7.3 13 6.7 0.1 2.9 2 1 0 2 2 2 0 Tombusvirus movement protein Ysc84 PF04366.12 EDN06261.1 - 1.6e-30 105.5 0.7 2.6e-30 104.8 0.7 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator RTA1 PF04479.13 EDN06265.1 - 1.2e-76 257.0 6.2 1.2e-76 257.0 6.2 1.4 2 0 0 2 2 2 1 RTA1 like protein DDE_1 PF03184.19 EDN06269.1 - 6.5e-06 25.9 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH PF17917.1 EDN06270.1 - 1e-45 154.3 0.5 5.2e-45 152.0 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN06270.1 - 6.9e-29 100.9 0.0 1.3e-28 100.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN06270.1 - 1.8e-27 95.3 0.0 3.6e-14 52.6 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06270.1 - 9.7e-20 70.4 0.2 2.1e-19 69.4 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN06270.1 - 1.1e-15 57.2 0.5 3.1e-15 55.8 0.5 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN06270.1 - 7.3e-07 29.4 0.0 1.8e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN06270.1 - 0.00034 20.8 0.0 0.00082 19.5 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 EDN06270.1 - 0.055 14.1 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 EDN06270.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease WD40 PF00400.32 EDN06271.1 - 2.4e-11 44.0 7.7 0.0041 17.9 0.4 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat Mg_trans_NIPA PF05653.14 EDN06272.1 - 2.5e-57 194.2 6.7 3.8e-57 193.7 6.7 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EDN06272.1 - 0.0013 18.9 0.6 0.0013 18.9 0.6 2.7 2 0 0 2 2 2 1 EamA-like transporter family SCP-1 PF05483.12 EDN06273.1 - 0.13 10.3 0.3 0.2 9.6 0.3 1.2 1 0 0 1 1 1 0 Synaptonemal complex protein 1 (SCP-1) VASt PF16016.5 EDN06274.1 - 3.4e-33 115.2 0.0 5.9e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDN06274.1 - 3e-22 78.6 0.0 5.1e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 GRAM domain TPR_2 PF07719.17 EDN06275.1 - 9.8e-07 28.4 0.1 0.11 12.7 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDN06275.1 - 5.4e-05 22.8 0.0 0.026 14.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN06275.1 - 0.00029 21.3 0.0 0.012 16.1 0.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN06275.1 - 0.039 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDN06275.1 - 0.04 14.2 0.1 2 8.8 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Asp PF00026.23 EDN06276.1 - 2.5e-55 188.1 0.0 3.1e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDN06276.1 - 3.5e-06 27.6 0.1 0.089 13.4 0.1 3.3 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDN06276.1 - 6.1e-05 23.5 0.1 0.26 11.9 0.1 3.2 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 EDN06276.1 - 0.00022 21.5 0.1 0.043 14.0 0.1 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDN06276.1 - 0.014 15.2 0.0 0.031 14.1 0.0 1.7 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal CAF1 PF04857.20 EDN06277.1 - 1.4e-12 47.5 0.0 5.9e-12 45.4 0.0 2.2 1 1 0 1 1 1 1 CAF1 family ribonuclease NDUF_B12 PF08122.12 EDN06278.1 - 2.4e-23 81.9 2.0 3.5e-23 81.4 2.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family YukC PF10140.9 EDN06278.1 - 0.24 10.2 0.0 0.29 9.9 0.0 1.0 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC WD40 PF00400.32 EDN06279.1 - 6.9e-18 64.7 3.7 0.033 15.1 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN06279.1 - 2.6e-06 27.7 0.0 0.0035 17.6 0.0 3.8 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain AMP-binding PF00501.28 EDN06280.1 - 1.9e-53 181.6 0.0 3.6e-26 91.7 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EDN06280.1 - 3.6e-16 59.9 0.1 7.5e-16 58.9 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Myb_DNA-binding PF00249.31 EDN06282.1 - 8.1e-12 45.2 0.0 1.5e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN06282.1 - 2.4e-05 24.5 0.1 5.3e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain BCS1_N PF08740.11 EDN06283.1 - 3.7e-29 102.0 0.0 6.7e-29 101.2 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN06283.1 - 1.1e-19 71.1 0.0 5.3e-19 69.0 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN06283.1 - 1e-05 26.0 0.1 2.7e-05 24.6 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN06283.1 - 0.042 12.7 0.0 0.073 11.9 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 EDN06283.1 - 0.047 13.4 0.0 0.21 11.3 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EDN06283.1 - 0.051 13.1 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN06283.1 - 0.053 13.5 0.0 0.16 11.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDN06283.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EDN06283.1 - 0.075 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EDN06283.1 - 0.12 13.0 0.1 2 9.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDN06283.1 - 0.12 12.5 0.0 2.3 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDN06283.1 - 0.13 11.4 0.0 0.94 8.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF815) Phasin_2 PF09361.10 EDN06284.1 - 0.087 13.1 1.0 0.24 11.7 1.0 1.7 1 0 0 1 1 1 0 Phasin protein SpecificRecomb PF10136.9 EDN06286.1 - 0.094 11.0 0.0 0.14 10.4 0.0 1.2 1 0 0 1 1 1 0 Site-specific recombinase APH PF01636.23 EDN06287.1 - 1.9e-06 28.0 0.8 9e-05 22.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 EDN06287.1 - 8.3e-06 25.4 0.0 2.1e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EDN06287.1 - 5.2e-05 22.7 0.1 9.6e-05 21.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AceK PF06315.11 EDN06287.1 - 0.00068 18.2 0.0 0.001 17.6 0.0 1.3 1 0 0 1 1 1 1 Isocitrate dehydrogenase kinase/phosphatase (AceK) Pkinase_Tyr PF07714.17 EDN06287.1 - 0.023 14.0 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Choline_kinase PF01633.20 EDN06287.1 - 0.057 13.0 0.0 0.23 11.0 0.0 1.7 1 1 0 2 2 2 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EDN06287.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF3435 PF11917.8 EDN06289.1 - 1.8e-167 557.5 0.3 2.5e-167 557.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN06289.1 - 8.5e-05 22.4 2.2 0.0032 17.3 0.0 2.6 3 0 0 3 3 3 2 Phage integrase family CNH PF00780.22 EDN06290.1 - 2.8e-44 151.8 0.0 5.5e-22 78.7 0.0 2.3 1 1 1 2 2 2 2 CNH domain RhoGEF PF00621.20 EDN06290.1 - 2.9e-33 115.7 0.6 5.3e-33 114.8 0.2 1.7 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 EDN06290.1 - 1.1e-12 48.2 0.0 1.2e-11 44.9 0.0 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_16 PF17838.1 EDN06290.1 - 0.00037 20.3 0.0 0.13 12.1 0.0 2.4 2 0 0 2 2 2 2 PH domain PH PF00169.29 EDN06290.1 - 0.0013 19.2 0.1 0.0079 16.7 0.0 2.3 3 0 0 3 3 3 1 PH domain PH_13 PF16652.5 EDN06290.1 - 0.1 12.4 0.3 1.9 8.3 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain RabGAP-TBC PF00566.18 EDN06291.1 - 8.8e-41 139.9 0.0 1.5e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 EDN06291.1 - 0.00014 21.7 0.0 0.00026 20.8 0.0 1.4 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.6 EDN06291.1 - 0.0074 16.1 5.9 0.022 14.7 0.1 3.6 3 0 0 3 3 3 1 EF-hand domain PepSY_TM PF03929.16 EDN06292.1 - 0.038 13.7 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region BRE1 PF08647.11 EDN06293.1 - 0.0036 17.3 9.6 0.0036 17.3 9.6 3.6 4 0 0 4 4 4 1 BRE1 E3 ubiquitin ligase UPF0242 PF06785.11 EDN06293.1 - 0.5 10.4 24.5 0.12 12.5 9.5 3.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 EDN06293.1 - 0.84 10.1 10.4 1.1 9.8 1.7 3.2 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.9 EDN06293.1 - 1.6 8.2 23.9 6 6.2 23.2 2.3 1 1 0 1 1 1 0 Golgin subfamily A member 5 HrpB7 PF09486.10 EDN06293.1 - 2.5 8.4 15.5 0.084 13.3 4.6 3.0 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF1664 PF07889.12 EDN06293.1 - 5.3 7.1 11.7 14 5.8 5.1 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) adh_short_C2 PF13561.6 EDN06294.1 - 1.5e-34 119.6 1.9 6.3e-34 117.6 1.9 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN06294.1 - 1.2e-27 96.7 0.5 2e-27 96.0 0.5 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN06294.1 - 8.1e-07 29.1 0.6 2e-06 27.9 0.1 1.7 2 0 0 2 2 2 1 KR domain PALP PF00291.25 EDN06294.1 - 0.012 15.0 1.3 0.032 13.7 0.2 2.0 1 1 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme DUF1772 PF08592.11 EDN06295.1 - 0.00076 19.8 1.8 0.001 19.4 1.8 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) APH PF01636.23 EDN06296.1 - 2.8e-09 37.3 0.5 1.1e-06 28.7 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN06296.1 - 0.0051 16.4 0.2 0.0068 16.0 0.2 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase AMP-binding PF00501.28 EDN06297.1 - 7e-73 245.6 0.0 8.9e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN06297.1 - 1.1e-13 52.0 0.1 2.8e-13 50.7 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AAA PF00004.29 EDN06298.1 - 4.1e-41 140.5 0.0 6.5e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDN06298.1 - 4.3e-10 39.4 0.1 8.8e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDN06298.1 - 2.5e-06 27.7 0.0 4.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EDN06298.1 - 5e-06 26.8 0.3 0.065 13.5 0.2 2.5 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EDN06298.1 - 4.2e-05 22.8 0.0 6.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EDN06298.1 - 7.5e-05 22.7 0.1 0.00025 21.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDN06298.1 - 0.00071 19.4 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDN06298.1 - 0.001 19.5 0.5 0.023 15.1 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EDN06298.1 - 0.0021 18.3 0.1 0.0046 17.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDN06298.1 - 0.0085 16.6 0.0 0.016 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EDN06298.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EDN06298.1 - 0.014 14.6 0.1 0.03 13.5 0.1 1.5 1 1 1 2 2 2 0 TIP49 P-loop domain ATPase PF06745.13 EDN06298.1 - 0.018 14.4 0.5 0.27 10.5 0.2 2.2 1 1 1 2 2 2 0 KaiC NACHT PF05729.12 EDN06298.1 - 0.023 14.6 0.2 1 9.2 0.2 2.3 1 1 1 2 2 2 0 NACHT domain AAA_3 PF07726.11 EDN06298.1 - 0.041 13.7 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDN06298.1 - 0.051 12.8 0.0 0.15 11.4 0.1 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 EDN06298.1 - 0.054 13.7 0.1 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EDN06298.1 - 0.079 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN06298.1 - 0.086 13.2 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EDN06298.1 - 0.1 11.8 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EDN06298.1 - 0.11 11.9 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EDN06298.1 - 0.11 12.8 0.4 0.29 11.5 0.4 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN06298.1 - 0.13 11.9 0.5 0.31 10.7 0.5 1.7 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 EDN06298.1 - 0.15 11.9 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.6 EDN06298.1 - 0.15 11.8 0.5 0.38 10.4 0.5 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDN06298.1 - 0.23 11.0 0.1 0.57 9.7 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region UQ_con PF00179.26 EDN06299.1 - 1.2e-42 144.9 0.0 1.6e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EDN06299.1 - 1.6e-06 27.8 0.1 3.9e-06 26.6 0.0 1.7 1 1 1 2 2 2 1 Fungal ubiquitin-associated domain DUF2095 PF09868.9 EDN06299.1 - 0.016 15.1 0.2 0.033 14.2 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) RWD PF05773.22 EDN06299.1 - 0.053 13.8 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 RWD domain Cyclin_C_2 PF16899.5 EDN06300.1 - 2.1e-35 121.2 0.1 4.5e-32 110.5 0.0 2.4 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 EDN06300.1 - 1.3e-05 24.9 0.0 3.1e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Xpo1 PF08389.12 EDN06300.1 - 0.084 12.9 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Exportin 1-like protein TMEM247 PF15444.6 EDN06300.1 - 1.2 9.1 3.9 0.38 10.7 0.5 1.8 2 0 0 2 2 2 0 Transmembrane protein 247 ABC_tran PF00005.27 EDN06301.1 - 5.1e-47 159.8 0.0 2.9e-23 82.9 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDN06301.1 - 5.1e-20 71.3 0.8 5.1e-20 71.3 0.8 3.0 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 EDN06301.1 - 3.4e-19 69.8 0.5 0.00024 21.0 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDN06301.1 - 2.9e-11 43.2 0.1 0.0014 18.2 0.0 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN06301.1 - 7.2e-08 32.1 0.5 0.003 17.3 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN06301.1 - 4.4e-07 30.0 0.2 0.0019 18.2 0.0 2.8 3 0 0 3 3 3 2 RsgA GTPase AAA_18 PF13238.6 EDN06301.1 - 5.2e-07 30.3 0.0 0.029 14.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EDN06301.1 - 1.3e-06 29.1 6.4 0.036 14.6 0.0 3.7 4 1 0 4 4 3 2 AAA domain AAA_15 PF13175.6 EDN06301.1 - 3.3e-06 27.1 3.7 0.021 14.5 0.0 3.0 4 0 0 4 4 4 2 AAA ATPase domain AAA_16 PF13191.6 EDN06301.1 - 7.7e-06 26.4 0.0 0.017 15.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EDN06301.1 - 2.3e-05 24.5 0.0 0.033 14.3 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EDN06301.1 - 6.9e-05 23.1 0.0 0.21 11.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDN06301.1 - 0.00015 22.1 1.8 1.1 9.7 0.0 3.5 3 0 0 3 3 3 2 RNA helicase NB-ARC PF00931.22 EDN06301.1 - 0.00029 20.1 0.0 1.4 8.1 0.0 3.3 2 1 0 2 2 2 2 NB-ARC domain AAA_27 PF13514.6 EDN06301.1 - 0.00043 19.9 0.0 0.44 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EDN06301.1 - 0.00044 20.2 0.1 1 9.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.6 EDN06301.1 - 0.00044 20.4 1.6 0.12 12.6 0.1 3.3 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.6 EDN06301.1 - 0.00048 20.4 0.0 0.23 11.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EDN06301.1 - 0.00053 20.4 0.0 0.88 10.0 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDN06301.1 - 0.0013 18.8 0.0 2.1 8.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDN06301.1 - 0.002 17.9 0.5 2.6 7.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 EDN06301.1 - 0.0047 17.2 0.1 5.2 7.3 0.1 3.0 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EDN06301.1 - 0.0096 15.7 1.1 2 8.1 0.1 3.3 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EDN06301.1 - 0.019 14.5 0.0 2.3 7.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_14 PF13173.6 EDN06301.1 - 0.025 14.6 0.0 11 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDN06301.1 - 0.035 13.2 0.0 4.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MeaB PF03308.16 EDN06301.1 - 0.042 12.8 0.5 4.6 6.1 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 EDN06301.1 - 0.053 13.4 0.0 14 5.5 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 EDN06301.1 - 0.063 12.8 0.0 0.96 9.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 EDN06301.1 - 0.069 13.0 0.0 10 5.9 0.0 2.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF2813 PF11398.8 EDN06301.1 - 0.074 12.3 0.0 10 5.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) PduV-EutP PF10662.9 EDN06301.1 - 0.08 12.7 0.5 3.4 7.4 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Phage_tail_2 PF06199.11 EDN06301.1 - 0.084 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Phage tail tube protein AAA_17 PF13207.6 EDN06301.1 - 0.089 13.2 0.0 23 5.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EDN06301.1 - 0.11 12.1 0.0 0.52 9.9 0.0 2.1 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain FixP_N PF14715.6 EDN06301.1 - 0.11 12.2 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP NTPase_1 PF03266.15 EDN06301.1 - 0.11 12.3 0.2 3.6 7.5 0.1 2.5 2 0 0 2 2 2 0 NTPase DUF87 PF01935.17 EDN06301.1 - 0.29 11.2 1.8 17 5.4 0.0 3.1 3 1 0 3 3 2 0 Helicase HerA, central domain AAA_13 PF13166.6 EDN06301.1 - 8.6 4.9 8.3 32 3.0 0.0 4.0 4 1 0 4 4 4 0 AAA domain HPP PF04982.13 EDN06302.1 - 4.6e-25 88.2 4.9 4.6e-25 88.2 4.9 1.6 2 0 0 2 2 2 1 HPP family MFS_1 PF07690.16 EDN06302.1 - 0.00036 19.6 1.1 0.04 12.9 0.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Mannosyl_trans2 PF04188.13 EDN06302.1 - 0.071 12.4 0.2 0.091 12.1 0.2 1.1 1 0 0 1 1 1 0 Mannosyltransferase (PIG-V) DUF3159 PF11361.8 EDN06302.1 - 0.11 12.2 3.4 0.13 12.0 2.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3159) Sec62 PF03839.16 EDN06303.1 - 0.26 10.8 7.2 0.2 11.2 5.0 1.8 2 0 0 2 2 2 0 Translocation protein Sec62 Mob_synth_C PF06463.13 EDN06305.1 - 0.18 11.7 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C GFO_IDH_MocA PF01408.22 EDN06306.1 - 2.8e-08 34.6 0.0 3.1e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Kelch_5 PF13854.6 EDN06307.1 - 9e-12 44.7 6.0 3.5e-07 30.1 0.0 5.7 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 EDN06307.1 - 2.5e-11 43.4 5.8 1.7e-06 27.9 0.4 4.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EDN06307.1 - 1.6e-10 40.8 2.9 0.003 17.8 0.4 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EDN06307.1 - 3.3e-06 26.6 5.3 0.0078 15.8 0.4 4.3 4 0 0 4 4 4 2 Kelch motif SKG6 PF08693.10 EDN06307.1 - 0.001 18.4 2.1 0.001 18.4 2.1 1.7 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Kelch_3 PF13415.6 EDN06307.1 - 0.0012 19.0 17.3 0.99 9.8 0.5 6.1 6 1 0 6 6 6 2 Galactose oxidase, central domain Trp_oprn_chp PF09534.10 EDN06307.1 - 0.01 15.6 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4536 PF15055.6 EDN06307.1 - 0.046 14.0 0.1 0.13 12.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) MGC-24 PF05283.11 EDN06307.1 - 0.16 12.4 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MARVEL PF01284.23 EDN06309.1 - 8.4e-07 29.1 1.2 1e-06 28.9 1.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF2142 PF09913.9 EDN06309.1 - 0.00036 19.5 0.0 0.00043 19.3 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2142) WSK PF03832.13 EDN06310.1 - 1.8 8.3 8.6 0.3 10.8 2.0 2.8 2 0 0 2 2 2 0 WSK motif RRM_1 PF00076.22 EDN06311.1 - 7.6e-29 99.3 0.0 4.8e-14 51.9 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN06311.1 - 0.0011 18.5 0.0 0.15 11.7 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN06311.1 - 0.0016 18.5 0.0 0.18 12.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif PHM7_cyt PF14703.6 EDN06311.1 - 0.0095 16.2 0.1 2.7 8.2 0.1 2.5 2 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter DUF4783 PF16022.5 EDN06311.1 - 0.21 11.8 0.0 0.93 9.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) FXMRP1_C_core PF12235.8 EDN06311.1 - 0.29 11.8 9.5 0.2 12.3 6.7 2.0 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal ArfGap PF01412.18 EDN06312.1 - 3.3e-17 62.6 0.0 5.4e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GTP_EFTU PF00009.27 EDN06313.1 - 1.9e-55 187.5 0.0 4.3e-55 186.3 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EDN06313.1 - 1e-24 86.4 0.0 2.3e-24 85.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDN06313.1 - 5.1e-08 32.8 0.1 1.2e-06 28.5 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDN06313.1 - 2.5e-05 24.6 0.0 8.2e-05 22.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDN06313.1 - 3.2e-05 23.8 0.0 6.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Vps5 PF09325.10 EDN06314.1 - 8.2e-13 48.4 2.5 1.5e-12 47.6 2.5 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EDN06314.1 - 2.3e-08 34.0 0.0 4.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 PX domain GFA PF04828.14 EDN06315.1 - 2.5e-14 53.4 0.1 3.8e-14 52.8 0.1 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Herpes_UL49_1 PF03117.14 EDN06315.1 - 0.00084 18.7 0.6 0.001 18.4 0.6 1.1 1 0 0 1 1 1 1 UL49 family ADK_lid PF05191.14 EDN06315.1 - 0.07 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid Rpr2 PF04032.16 EDN06315.1 - 0.079 13.3 0.1 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain C1_1 PF00130.22 EDN06315.1 - 0.12 12.3 3.3 0.22 11.4 0.1 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Epimerase PF01370.21 EDN06316.1 - 2.1e-14 53.6 0.1 4.7e-06 26.2 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDN06316.1 - 2.7e-06 27.4 0.0 4.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDN06316.1 - 3.9e-06 26.6 0.0 5.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 EDN06316.1 - 8.3e-06 26.2 0.0 1.4e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EDN06316.1 - 0.00019 20.9 0.1 0.0034 16.8 0.0 2.5 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EDN06316.1 - 0.0042 16.1 0.0 0.37 9.8 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Silic_transp PF03842.13 EDN06316.1 - 0.037 12.3 0.0 0.054 11.8 0.0 1.1 1 0 0 1 1 1 0 Silicon transporter THOC2_N PF16134.5 EDN06317.1 - 1e-251 837.1 0.0 1.4e-251 836.7 0.0 1.2 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Thoc2 PF11732.8 EDN06317.1 - 1.1e-30 105.5 0.0 3.2e-30 104.0 0.0 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Tho2 PF11262.8 EDN06318.1 - 3.6e-104 348.2 0.0 6.7e-104 347.3 0.0 1.5 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 CN_hydrolase PF00795.22 EDN06320.1 - 0.09 12.1 0.0 5.6 6.2 0.0 2.2 1 1 0 2 2 2 0 Carbon-nitrogen hydrolase Fim-adh_lectin PF09222.10 EDN06320.1 - 0.19 11.2 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Fimbrial adhesin F17-AG, lectin domain MitMem_reg PF13012.6 EDN06323.1 - 0.038 14.4 0.0 0.061 13.8 0.0 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function DUF2514 PF10721.9 EDN06323.1 - 0.099 12.7 0.2 0.11 12.6 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) JAB PF01398.21 EDN06324.1 - 8e-08 32.3 0.0 1.1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RNA_pol_3_Rpc31 PF11705.8 EDN06326.1 - 9.4e-72 241.9 8.2 1.1e-71 241.7 8.2 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 FAD_binding_1 PF00667.20 EDN06327.1 - 2.8e-18 66.3 0.0 1.3e-15 57.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_1 PF00175.21 EDN06327.1 - 1.7e-08 35.1 0.0 4.5e-07 30.5 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain ETF PF01012.21 EDN06328.1 - 2.2e-43 148.2 0.3 2.7e-43 148.0 0.3 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain DUF488 PF04343.13 EDN06329.1 - 2.9e-14 53.7 0.0 4.8e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF488 RTC PF01137.21 EDN06330.1 - 1.1e-49 168.6 0.0 2.2e-49 167.6 0.0 1.5 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Exo_endo_phos PF03372.23 EDN06330.1 - 2.2e-05 24.1 0.0 4.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YibE_F PF07907.11 EDN06332.1 - 0.015 14.8 0.3 0.025 14.1 0.3 1.3 1 0 0 1 1 1 0 YibE/F-like protein DUF2569 PF10754.9 EDN06332.1 - 1.9 9.0 13.0 5 7.6 0.4 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF2569) DUF996 PF06195.13 EDN06332.1 - 3.3 8.0 8.7 31 4.8 7.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF996) DUF2439 PF10382.9 EDN06334.1 - 2.5e-24 85.4 0.0 4.5e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) SWIRM-assoc_2 PF16496.5 EDN06335.1 - 0.03 13.2 0.1 0.034 13.0 0.1 1.0 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DUF3697 PF12478.8 EDN06335.1 - 0.18 11.9 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-associated protein 2 DUF3405 PF11885.8 EDN06336.1 - 2e-160 534.9 2.1 9.7e-160 532.6 2.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3405) Mcp5_PH PF12814.7 EDN06337.1 - 1.1e-47 161.1 0.2 2.2e-47 160.1 0.2 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EDN06337.1 - 1.7e-07 31.7 0.3 5.7e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 PH domain HAP1_N PF04849.13 EDN06337.1 - 3.2 6.9 42.3 0.081 12.1 0.2 4.5 3 1 1 4 4 4 0 HAP1 N-terminal conserved region Selenoprotein_S PF06936.11 EDN06337.1 - 6.2 6.6 14.2 3.2 7.5 5.4 3.0 2 0 0 2 2 2 0 Selenoprotein S (SelS) zf-C3HC4_3 PF13920.6 EDN06338.1 - 1.5e-07 31.2 6.0 2.6e-07 30.4 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN06338.1 - 2.8e-07 30.3 8.7 4.7e-07 29.5 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN06338.1 - 3.1e-07 30.3 6.7 5.8e-07 29.4 6.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDN06338.1 - 6.5e-07 29.2 9.0 1.1e-06 28.5 9.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-CCCH PF00642.24 EDN06338.1 - 8.9e-07 28.7 2.3 2.2e-06 27.4 2.3 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_10 PF16685.5 EDN06338.1 - 9.1e-07 28.9 3.4 1.8e-06 28.0 3.4 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4 PF00097.25 EDN06338.1 - 3.7e-06 26.7 10.4 6.2e-06 26.0 10.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN06338.1 - 8e-06 26.1 7.3 1.5e-05 25.2 7.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 EDN06338.1 - 0.00048 20.1 5.2 0.0012 18.8 5.2 1.8 1 0 0 1 1 1 1 Zinc finger domain Prok-RING_4 PF14447.6 EDN06338.1 - 0.0012 18.7 6.8 0.0021 17.9 6.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDN06338.1 - 0.0035 17.5 9.2 0.0072 16.5 9.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 EDN06338.1 - 0.025 14.4 2.4 0.025 14.4 2.4 2.2 2 0 0 2 2 2 0 CCCH-type zinc finger zf-Nse PF11789.8 EDN06338.1 - 0.055 13.3 2.2 0.095 12.5 2.2 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EDN06338.1 - 0.12 12.6 4.9 0.24 11.7 4.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-CCCH_2 PF14608.6 EDN06338.1 - 1 9.9 5.9 0.21 12.1 1.8 2.1 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger RT_RNaseH PF17917.1 EDN06339.1 - 5e-37 126.4 0.0 1.1e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN06339.1 - 1.7e-32 111.4 0.0 5.3e-32 109.8 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06339.1 - 6e-20 71.1 0.3 1.5e-19 69.8 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 EDN06339.1 - 1.6e-15 57.2 0.1 1.1e-13 51.2 0.0 2.4 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06339.1 - 2.5e-12 47.0 0.0 7.8e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN06339.1 - 0.0016 18.7 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger SRI PF08236.11 EDN06341.1 - 4.5e-21 74.8 14.0 1.8e-20 72.9 14.0 2.1 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain Med26 PF08711.11 EDN06341.1 - 0.0045 17.0 0.1 0.0045 17.0 0.1 2.5 2 0 0 2 2 2 1 TFIIS helical bundle-like domain WW PF00397.26 EDN06341.1 - 0.018 15.1 0.4 0.049 13.7 0.4 1.8 1 0 0 1 1 1 0 WW domain eIF-6 PF01912.18 EDN06342.1 - 5.8e-28 97.6 0.0 6.1e-28 97.5 0.0 1.0 1 0 0 1 1 1 1 eIF-6 family DUF3431 PF11913.8 EDN06343.1 - 4.8e-42 144.2 5.6 2.3e-29 102.7 2.5 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3431) Ku PF02735.16 EDN06347.1 - 1.8e-43 148.6 0.0 3.9e-43 147.6 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EDN06347.1 - 4.3e-34 118.2 0.0 6.1e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EDN06347.1 - 3.7e-26 91.6 1.5 1.2e-25 90.0 1.5 1.9 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm Ferrochelatase PF00762.19 EDN06348.1 - 1.5e-70 237.8 0.0 1.7e-70 237.7 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase ADH_zinc_N PF00107.26 EDN06349.1 - 6.6e-26 90.8 0.7 1.2e-25 89.9 0.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDN06349.1 - 5.2e-17 63.1 0.0 9.8e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN06349.1 - 4.3e-09 36.2 0.0 7.9e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EDN06349.1 - 0.02 15.1 0.0 0.048 13.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain RT_RNaseH PF17917.1 EDN06351.1 - 1.3e-34 118.7 0.0 2.6e-34 117.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN06351.1 - 3.8e-24 84.6 0.1 7.9e-13 48.3 0.0 2.5 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06351.1 - 1.4e-19 69.9 0.2 3.5e-19 68.7 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN06351.1 - 2.2e-15 56.9 0.0 7.2e-15 55.2 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 EDN06351.1 - 9.3e-06 25.8 0.1 1.8e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger PSII_Pbs27 PF13326.6 EDN06351.1 - 0.11 12.8 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Photosystem II Pbs27 MFS_1 PF07690.16 EDN06352.1 - 5.1e-23 81.6 32.4 8e-23 80.9 32.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN06352.1 - 1.8e-06 27.1 4.2 1.8e-06 27.1 4.2 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EDN06352.1 - 0.37 9.0 8.1 0.68 8.2 5.8 2.4 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SE PF08491.10 EDN06354.1 - 1.6e-96 322.6 0.0 1.9e-96 322.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EDN06354.1 - 8.5e-13 48.3 0.0 2e-11 43.8 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 EDN06354.1 - 4.4e-07 29.3 0.9 4.7e-05 22.7 1.0 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EDN06354.1 - 4.7e-07 29.7 0.4 1.8e-05 24.5 0.7 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EDN06354.1 - 1.3e-06 27.8 0.0 1.7e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDN06354.1 - 1.9e-05 24.8 0.6 4.4e-05 23.6 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EDN06354.1 - 4.9e-05 22.9 0.0 6.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN06354.1 - 9.9e-05 21.7 0.1 0.00018 20.8 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDN06354.1 - 0.0004 19.5 0.2 0.00083 18.5 0.1 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EDN06354.1 - 0.0015 17.4 0.1 0.0033 16.2 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EDN06354.1 - 0.0023 17.2 0.0 0.0067 15.7 0.0 1.6 2 0 0 2 2 2 1 Thi4 family ApbA PF02558.16 EDN06354.1 - 0.007 16.0 0.2 0.012 15.3 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EDN06354.1 - 0.061 12.2 0.1 0.67 8.7 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 EDN06354.1 - 0.075 13.6 1.1 0.27 11.8 0.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN06354.1 - 0.21 10.8 0.2 0.39 9.9 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PAP_assoc PF03828.19 EDN06355.1 - 4.6e-08 33.2 0.9 8e-07 29.2 0.9 2.5 1 1 0 1 1 1 1 Cid1 family poly A polymerase CorA PF01544.18 EDN06358.1 - 1.4e-10 41.0 0.8 4.9e-10 39.2 0.8 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2013 PF09431.10 EDN06362.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2013) DCP1 PF06058.13 EDN06363.1 - 5.4e-28 97.3 0.0 9.8e-28 96.4 0.0 1.4 1 0 0 1 1 1 1 Dcp1-like decapping family Pex14_N PF04695.13 EDN06363.1 - 1.9 9.2 16.7 0.62 10.7 6.9 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LIDHydrolase PF10230.9 EDN06364.1 - 1.2e-54 185.7 0.0 4.7e-54 183.7 0.0 1.8 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 EDN06364.1 - 0.00071 20.2 0.0 0.003 18.2 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN06364.1 - 0.0014 17.9 0.1 0.016 14.5 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Trep_Strep PF09605.10 EDN06364.1 - 0.11 12.5 0.1 18 5.2 0.1 2.2 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Thioesterase PF00975.20 EDN06364.1 - 0.12 12.4 0.2 0.37 10.9 0.1 1.8 1 1 1 2 2 2 0 Thioesterase domain EMP24_GP25L PF01105.24 EDN06364.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DEAD PF00270.29 EDN06365.1 - 2.2e-09 37.3 0.0 4.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN06365.1 - 5.5e-05 23.2 0.0 0.00014 21.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN06365.1 - 0.03 14.6 0.2 0.13 12.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain Sigma70_ner PF04546.13 EDN06366.1 - 0.25 11.2 5.7 0.42 10.5 5.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.12 EDN06366.1 - 2.1 7.6 5.0 2.9 7.1 5.0 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EDN06366.1 - 4.3 7.8 8.4 8.6 6.8 8.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 EDN06366.1 - 8.3 4.4 7.1 11 4.0 7.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi HNH_2 PF13391.6 EDN06367.1 - 1.1e-16 60.7 0.2 4e-16 58.9 0.1 1.9 2 0 0 2 2 2 1 HNH endonuclease SMK-1 PF04802.15 EDN06368.1 - 1.9e-62 210.5 0.3 5.3e-62 209.1 0.3 1.7 1 1 0 1 1 1 1 Component of IIS longevity pathway SMK-1 SLC35F PF06027.12 EDN06369.1 - 2.6e-102 342.4 20.7 3e-102 342.2 20.7 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EDN06369.1 - 2.1e-09 36.8 4.8 3.1e-09 36.2 4.8 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EDN06369.1 - 7.5e-08 32.6 33.1 0.00033 20.8 15.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family HSBP1 PF06825.12 EDN06370.1 - 0.062 13.2 0.2 0.3 11.0 0.0 2.1 2 0 0 2 2 2 0 Heat shock factor binding protein 1 STE3 PF02076.15 EDN06371.1 - 6.5e-93 311.1 18.5 7.5e-93 310.9 18.5 1.0 1 0 0 1 1 1 1 Pheromone A receptor BRI3BP PF14965.6 EDN06371.1 - 0.39 10.2 3.3 1.1 8.8 3.3 1.7 1 0 0 1 1 1 0 Negative regulator of p53/TP53 Pex24p PF06398.11 EDN06371.1 - 0.55 9.2 11.6 0.058 12.4 3.8 2.3 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin SSB PF00436.25 EDN06372.1 - 5.2e-16 58.6 0.0 7.1e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family DUF4203 PF13886.6 EDN06374.1 - 2.7e-11 43.5 3.4 4.2e-11 42.9 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Erf4 PF10256.9 EDN06375.1 - 5.9e-41 139.2 0.0 8.4e-41 138.7 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Adap_comp_sub PF00928.21 EDN06376.1 - 2e-67 227.4 0.0 1.2e-53 182.2 0.0 2.1 1 1 1 2 2 2 2 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDN06376.1 - 0.011 15.6 1.2 0.07 13.1 0.5 2.3 1 1 1 2 2 2 0 Clathrin adaptor complex small chain APH PF01636.23 EDN06377.1 - 8.8e-08 32.4 0.2 3.8e-07 30.3 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN06377.1 - 0.0042 16.4 0.0 0.01 15.2 0.0 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 EDN06377.1 - 0.055 12.7 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase DUF3246 PF11596.8 EDN06377.1 - 0.12 11.8 0.1 0.2 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Myb_DNA-bind_6 PF13921.6 EDN06378.1 - 0.00028 21.1 0.0 0.00081 19.6 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain FUSC PF04632.12 EDN06378.1 - 0.46 9.0 1.9 0.68 8.4 1.9 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Nucleo_P87 PF07267.11 EDN06378.1 - 1.5 7.5 6.1 0.15 10.9 1.2 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Pkinase PF00069.25 EDN06379.1 - 2e-58 197.9 1.1 2.5e-54 184.4 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06379.1 - 4.4e-32 111.4 0.0 1.1e-30 106.9 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN06379.1 - 8.1e-06 24.9 0.0 1.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDN06379.1 - 9.4e-06 25.1 0.0 2.5e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDN06379.1 - 0.0015 17.9 0.0 0.0022 17.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDN06379.1 - 0.017 15.1 0.2 0.047 13.6 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family bVLRF1 PF18826.1 EDN06380.1 - 3.7e-62 208.6 1.5 7.6e-62 207.6 0.3 2.1 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EDN06380.1 - 0.0058 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN06380.1 - 0.0086 16.5 0.0 0.026 15.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat zf-C2H2_jaz PF12171.8 EDN06380.1 - 0.19 12.0 2.1 0.42 11.0 2.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ank PF00023.30 EDN06380.1 - 0.29 11.6 0.8 0.72 10.4 0.8 1.6 1 0 0 1 1 1 0 Ankyrin repeat ABC_membrane PF00664.23 EDN06381.1 - 1.8e-38 132.7 11.1 3.7e-38 131.8 11.1 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDN06381.1 - 9.8e-20 71.5 0.0 5.6e-19 69.0 0.0 2.3 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDN06381.1 - 0.00063 19.3 0.1 0.85 9.0 0.1 2.5 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EDN06381.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 EDN06381.1 - 0.019 15.5 0.0 0.056 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EDN06381.1 - 0.025 14.6 0.3 0.091 12.9 0.0 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDN06381.1 - 0.032 14.3 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 Dynamin family AAA_27 PF13514.6 EDN06381.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF999 PF06198.11 EDN06381.1 - 0.066 13.2 0.6 0.31 11.0 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF999) DUP PF00674.18 EDN06381.1 - 0.067 13.3 2.3 0.1 12.8 0.3 2.4 2 0 0 2 2 2 0 DUP family AAA_29 PF13555.6 EDN06381.1 - 0.072 12.8 0.0 0.36 10.6 0.0 2.2 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDN06382.1 - 2.4e-25 89.7 0.1 1.4e-24 87.2 0.1 2.1 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDN06382.1 - 3.6e-22 79.3 2.4 4.5e-22 79.0 2.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDN06382.1 - 6.4e-06 25.8 1.6 0.00037 20.0 0.2 2.1 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDN06382.1 - 0.0041 17.5 0.3 0.0074 16.7 0.3 1.4 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EDN06382.1 - 0.051 13.7 0.3 0.13 12.4 0.3 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase IstB_IS21 PF01695.17 EDN06382.1 - 0.059 13.1 0.5 4.1 7.1 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF2841 PF11001.8 EDN06383.1 - 2.7e-48 163.1 0.7 4.6e-48 162.4 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) VbhA PF18495.1 EDN06383.1 - 0.046 13.6 0.6 0.081 12.8 0.6 1.4 1 0 0 1 1 1 0 Antitoxin VbhA CorA PF01544.18 EDN06383.1 - 0.15 11.3 0.4 0.22 10.8 0.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Ago_PAZ PF18309.1 EDN06383.1 - 0.18 12.5 1.6 0.37 11.5 0.1 2.3 3 0 0 3 3 3 0 Argonaute PAZ domain GATase PF00117.28 EDN06384.1 - 2.3e-26 92.7 0.0 2.5e-25 89.4 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDN06384.1 - 0.0033 17.2 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 SAC3_GANP PF03399.16 EDN06386.1 - 2.7e-87 292.9 2.2 3.9e-87 292.4 2.2 1.2 1 0 0 1 1 1 1 SAC3/GANP family Zip PF02535.22 EDN06386.1 - 2.1e-39 135.7 2.6 5.8e-27 94.8 0.1 2.3 2 0 0 2 2 2 2 ZIP Zinc transporter CSN8_PSD8_EIF3K PF10075.9 EDN06386.1 - 1.7e-06 28.0 0.1 7.7e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family ssDNA-exonuc_C PF10141.9 EDN06386.1 - 0.033 13.8 0.2 0.057 13.1 0.2 1.3 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain SAC3_GANP PF03399.16 EDN06387.1 - 2.3e-105 352.2 2.9 2.7e-105 352.0 2.9 1.1 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EDN06387.1 - 9.7e-07 28.9 0.1 9.1e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family ssDNA-exonuc_C PF10141.9 EDN06387.1 - 0.02 14.5 0.1 0.034 13.8 0.1 1.3 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain Sec8_exocyst PF04048.14 EDN06388.1 - 1.8e-45 154.3 0.5 1.3e-44 151.6 0.1 2.5 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EDN06388.1 - 9.9e-08 31.6 0.1 2.3e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 EDN06388.1 - 0.0062 15.2 0.1 0.016 13.8 0.1 1.6 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 HIP1_clath_bdg PF16515.5 EDN06388.1 - 2.6 8.7 5.6 8.8 7.0 0.0 2.9 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Creatinase_N_2 PF16189.5 EDN06389.1 - 2.6e-55 186.9 0.1 6e-54 182.5 0.0 2.5 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EDN06389.1 - 4.1e-43 147.5 0.0 5.5e-43 147.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EDN06389.1 - 5.6e-23 80.8 1.2 1.4e-22 79.5 1.2 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EDN06389.1 - 5.5e-20 72.4 0.0 1.7e-17 64.3 0.0 3.0 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Importin_rep PF18773.1 EDN06390.1 - 0.0033 17.1 0.1 0.0078 15.9 0.1 1.7 1 0 0 1 1 1 1 Importin 13 repeat IBN_N PF03810.19 EDN06390.1 - 0.0099 15.8 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 Importin-beta N-terminal domain SOR_SNZ PF01680.17 EDN06391.1 - 5.5e-109 362.7 3.2 8.9e-109 362.1 3.2 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EDN06391.1 - 2.3e-10 40.2 4.3 2.2e-07 30.5 0.1 2.5 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EDN06391.1 - 0.0018 17.4 1.4 0.55 9.3 0.1 2.6 2 2 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EDN06391.1 - 0.0062 16.0 0.4 0.57 9.6 0.0 2.8 2 1 0 2 2 2 1 Histidine biosynthesis protein IGPS PF00218.21 EDN06391.1 - 0.012 14.9 0.0 0.47 9.6 0.0 2.6 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase NanE PF04131.14 EDN06391.1 - 0.013 14.6 0.4 0.34 10.1 0.0 2.4 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase TetR_C_27 PF17935.1 EDN06391.1 - 0.021 14.9 0.0 0.057 13.5 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain NMO PF03060.15 EDN06391.1 - 0.1 12.0 4.5 1 8.7 0.1 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase FUN14 PF04930.15 EDN06392.1 - 2.4e-05 24.6 0.0 3.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 FUN14 family ORC2 PF04084.14 EDN06393.1 - 5.4e-108 360.8 0.0 6.7e-108 360.5 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 ArgJ PF01960.18 EDN06394.1 - 1.8e-139 464.6 0.3 2.1e-139 464.4 0.3 1.0 1 0 0 1 1 1 1 ArgJ family SecY PF00344.20 EDN06395.1 - 3.6e-73 246.5 7.0 4.4e-73 246.2 7.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDN06395.1 - 2.2e-17 62.6 0.3 6e-17 61.2 0.3 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p DUF2975 PF11188.8 EDN06395.1 - 4.1 7.3 6.4 1.8 8.5 1.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2975) DUF3584 PF12128.8 EDN06396.1 - 0.0023 15.6 22.0 0.0031 15.1 22.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF641 PF04859.12 EDN06396.1 - 0.019 15.3 3.7 0.019 15.3 3.7 3.9 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) DUF3450 PF11932.8 EDN06396.1 - 0.19 11.0 19.3 0.016 14.5 9.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) RPA_interact_N PF14766.6 EDN06396.1 - 0.58 9.8 4.1 17 5.2 0.1 3.8 3 0 0 3 3 3 0 Replication protein A interacting N-terminal GvpG PF05120.12 EDN06396.1 - 1.6 8.8 9.2 3.5 7.7 3.6 3.0 1 1 1 2 2 2 0 Gas vesicle protein G AATF-Che1 PF13339.6 EDN06396.1 - 4.8 7.9 17.9 30 5.3 8.6 3.3 1 1 2 3 3 3 0 Apoptosis antagonizing transcription factor APG6_N PF17675.1 EDN06396.1 - 7.4 7.1 41.1 4.9 7.7 15.6 3.4 1 1 2 3 3 3 0 Apg6 coiled-coil region T5orf172 PF10544.9 EDN06400.1 - 3.8e-25 88.4 0.6 9.9e-25 87.1 0.6 1.7 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 EDN06400.1 - 3.1e-23 82.2 0.6 5.5e-23 81.4 0.6 1.4 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 DUF1179 PF06678.11 EDN06400.1 - 0.26 11.3 1.0 20 5.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) ABC_tran PF00005.27 EDN06401.1 - 2.7e-33 115.4 0.0 4e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDN06401.1 - 8.8e-07 28.6 0.9 4.4e-05 23.0 0.4 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDN06401.1 - 0.00093 19.6 0.6 0.0051 17.2 0.6 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EDN06401.1 - 0.0012 18.7 0.1 0.027 14.3 0.0 2.0 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDN06401.1 - 0.0019 18.5 0.1 0.017 15.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDN06401.1 - 0.0027 18.1 0.2 0.79 10.2 0.1 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDN06401.1 - 0.0042 16.8 0.2 0.32 10.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 EDN06401.1 - 0.0055 15.6 1.0 0.0059 15.5 0.1 1.4 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_28 PF13521.6 EDN06401.1 - 0.036 14.3 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDN06401.1 - 0.058 13.1 0.4 0.13 12.0 0.1 1.7 2 0 0 2 2 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN06401.1 - 0.064 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Rad17 PF03215.15 EDN06401.1 - 0.064 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain SbcCD_C PF13558.6 EDN06401.1 - 0.064 13.5 0.7 0.85 9.9 0.7 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 EDN06401.1 - 0.088 12.4 0.0 0.85 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EDN06401.1 - 0.16 11.1 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit ABC_membrane PF00664.23 EDN06402.1 - 9.7e-89 297.7 35.5 7.2e-50 170.2 21.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDN06402.1 - 5.9e-32 111.0 0.0 1.3e-31 109.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDN06402.1 - 7.5e-07 28.8 0.1 0.00092 18.7 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN06402.1 - 0.002 17.9 0.1 0.0053 16.5 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN06402.1 - 0.0034 17.3 0.0 0.063 13.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 EDN06402.1 - 0.01 15.6 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_16 PF13191.6 EDN06402.1 - 0.012 16.0 0.2 0.045 14.1 0.2 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EDN06402.1 - 0.018 15.4 0.7 3.4 8.1 0.4 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EDN06402.1 - 0.019 14.5 0.0 0.057 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDN06402.1 - 0.03 14.6 0.0 0.25 11.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain Pam17 PF08566.10 EDN06402.1 - 0.065 13.1 0.3 0.18 11.6 0.3 1.7 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Anoctamin PF04547.12 EDN06402.1 - 4.3 6.1 6.9 0.44 9.3 1.8 1.9 2 0 0 2 2 2 0 Calcium-activated chloride channel Ribosomal_L39 PF00832.20 EDN06404.1 - 6.3e-22 76.9 9.4 7.3e-22 76.7 9.4 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Skp1 PF01466.19 EDN06405.1 - 1.4e-27 95.5 0.4 2.4e-27 94.8 0.4 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EDN06405.1 - 5.3e-13 48.9 0.2 1.4e-12 47.6 0.1 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Glyco_transf_22 PF03901.17 EDN06406.1 - 1.9e-23 83.4 16.5 1.3e-13 50.9 5.4 3.1 2 1 1 3 3 3 3 Alg9-like mannosyltransferase family p450 PF00067.22 EDN06407.1 - 3.7e-57 194.1 0.0 1.5e-56 192.1 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Propep_M14 PF02244.16 EDN06407.1 - 0.17 12.3 0.1 0.4 11.1 0.1 1.7 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Sybindin PF04099.12 EDN06408.1 - 3.9e-27 94.9 0.0 4.8e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EDN06408.1 - 0.0016 18.5 0.1 0.0024 18.0 0.1 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Pkinase PF00069.25 EDN06409.1 - 1.6e-45 155.6 0.0 3.3e-45 154.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06409.1 - 2.4e-30 105.7 0.0 4.6e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN06409.1 - 1e-07 31.6 0.0 5.7e-07 29.1 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDN06409.1 - 0.012 14.4 0.4 0.012 14.4 0.4 2.3 2 1 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EDN06409.1 - 0.019 14.9 0.1 0.049 13.5 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Methyltransf_23 PF13489.6 EDN06411.1 - 4.4e-14 52.6 0.0 6.9e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN06411.1 - 7.7e-08 32.3 0.0 6.5e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN06411.1 - 9.8e-06 26.2 0.0 7.2e-05 23.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN06411.1 - 1.7e-05 25.4 0.0 4.5e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EDN06411.1 - 0.00031 20.3 0.0 0.00066 19.2 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EDN06411.1 - 0.011 15.3 0.0 0.037 13.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EDN06411.1 - 0.019 14.3 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain DUF2299 PF10061.9 EDN06411.1 - 0.038 13.7 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2299) Methyltransf_11 PF08241.12 EDN06411.1 - 0.071 13.8 0.0 0.21 12.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain YodL PF14191.6 EDN06411.1 - 0.13 13.1 0.0 0.32 11.9 0.0 1.6 1 0 0 1 1 1 0 YodL-like PhyH PF05721.13 EDN06412.1 - 2.1e-10 41.2 0.0 2.2e-09 37.9 0.0 2.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Cupin_2 PF07883.11 EDN06412.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Brix PF04427.18 EDN06413.1 - 8.2e-10 39.1 0.1 9.4e-10 38.9 0.1 1.1 1 0 0 1 1 1 1 Brix domain HGTP_anticodon PF03129.20 EDN06414.1 - 2e-20 72.7 1.2 1e-19 70.5 0.0 2.8 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDN06414.1 - 1.2e-09 38.4 0.1 3.3e-08 33.7 0.1 2.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Pkinase PF00069.25 EDN06416.1 - 1.3e-68 231.3 0.5 1.7e-67 227.6 0.5 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06416.1 - 1.3e-51 175.4 0.0 2.4e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PH_11 PF15413.6 EDN06416.1 - 9.4e-26 90.3 0.3 3.8e-25 88.3 0.3 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PBD PF00786.28 EDN06416.1 - 1.6e-21 76.4 0.4 9.4e-21 73.9 0.0 2.5 3 0 0 3 3 3 1 P21-Rho-binding domain Haspin_kinase PF12330.8 EDN06416.1 - 3.5e-06 26.2 0.1 3.5e-06 26.2 0.1 2.1 3 0 0 3 3 3 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDN06416.1 - 7.3e-06 25.0 0.0 7.3e-06 25.0 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 EDN06416.1 - 1.3e-05 24.7 0.0 2.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PH PF00169.29 EDN06416.1 - 0.00071 20.0 0.3 0.0017 18.8 0.3 1.7 1 0 0 1 1 1 1 PH domain APH PF01636.23 EDN06416.1 - 0.0013 18.7 3.1 0.017 15.1 0.1 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family KIND PF16474.5 EDN06416.1 - 0.0051 16.7 0.0 0.017 15.1 0.0 1.9 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain Seadorna_VP7 PF07387.11 EDN06416.1 - 0.04 13.0 0.0 0.075 12.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 NAD_kinase PF01513.21 EDN06417.1 - 8.2e-34 117.1 0.2 1.1e-33 116.7 0.2 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Sulfotransfer_4 PF17784.1 EDN06419.1 - 2.6e-50 171.2 0.3 7.8e-50 169.7 0.3 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Acyltransferase PF01553.21 EDN06420.1 - 2.2e-21 75.9 0.0 3.9e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EDN06420.1 - 1e-15 57.5 0.1 1.8e-15 56.8 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus TPR_19 PF14559.6 EDN06421.1 - 3.3e-19 69.2 20.6 1.9e-05 25.1 0.2 9.6 8 2 2 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 EDN06421.1 - 1.4e-18 65.5 22.3 0.0024 17.9 0.1 10.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 EDN06421.1 - 2.3e-18 65.2 19.5 0.00017 21.2 0.2 8.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDN06421.1 - 3.1e-13 49.3 15.8 0.14 13.1 0.1 10.0 9 2 1 10 10 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDN06421.1 - 4.2e-12 46.2 19.1 0.0013 19.0 0.2 8.4 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDN06421.1 - 1.7e-11 43.4 20.0 0.0031 17.6 0.2 8.7 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN06421.1 - 3.9e-08 32.8 17.0 0.024 14.3 0.1 7.2 5 1 1 6 6 6 4 TPR repeat TPR_6 PF13174.6 EDN06421.1 - 5.4e-07 29.8 25.4 0.46 11.2 0.1 10.6 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN06421.1 - 3.6e-06 27.5 21.1 0.19 12.4 0.4 7.2 7 1 1 8 8 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDN06421.1 - 1e-05 25.2 24.4 0.0027 17.6 0.1 8.5 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN06421.1 - 9.1e-05 22.6 3.3 1.8 8.8 0.3 5.0 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDN06421.1 - 0.00021 21.5 14.4 0.11 12.9 0.1 8.8 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_4 PF07721.14 EDN06421.1 - 0.51 11.1 4.6 2.8 8.8 1.3 4.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDN06421.1 - 0.63 10.0 23.7 0.61 10.0 0.2 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat SGL PF08450.12 EDN06422.1 - 3.8e-27 95.5 0.3 8.6e-13 48.4 0.1 2.3 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EDN06422.1 - 0.099 12.9 0.3 0.69 10.1 0.0 2.6 3 0 0 3 3 3 0 Arylesterase Fungal_trans_2 PF11951.8 EDN06423.1 - 4.9e-05 22.3 0.2 6.6e-05 21.9 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CBM9_2 PF16011.5 EDN06424.1 - 7e-07 29.1 0.1 1.2e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate-binding family 9 PBD PF00786.28 EDN06425.1 - 0.09 13.2 0.8 0.24 11.8 0.8 1.7 1 0 0 1 1 1 0 P21-Rho-binding domain Es2 PF09751.9 EDN06426.1 - 2.9e-139 465.5 11.5 2.9e-139 465.5 11.5 1.3 2 0 0 2 2 2 1 Nuclear protein Es2 Mid1 PF12929.7 EDN06427.1 - 8.3e-155 516.2 3.5 9.9e-155 515.9 3.5 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EDN06427.1 - 0.00072 20.2 6.4 0.064 13.9 1.7 2.5 2 0 0 2 2 2 2 Fz domain Kin17_mid PF10357.9 EDN06428.1 - 8e-53 177.7 0.4 1.5e-52 176.8 0.4 1.4 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EDN06428.1 - 0.0004 20.7 2.6 0.00079 19.7 2.6 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDN06428.1 - 0.0016 18.6 1.3 0.0032 17.7 1.3 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EDN06428.1 - 0.0096 16.2 2.5 0.012 15.9 0.2 2.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) CorA PF01544.18 EDN06429.1 - 1e-38 133.3 0.0 1.6e-38 132.7 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF281 PF03436.13 EDN06431.1 - 0.1 13.0 1.0 3 8.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF281) zf-rbx1 PF12678.7 EDN06433.1 - 5.4e-16 58.6 2.4 7.6e-16 58.1 2.4 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDN06433.1 - 6.7e-10 38.9 4.2 1e-09 38.3 4.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EDN06433.1 - 0.11 12.8 6.6 1.9 8.9 6.6 2.3 1 1 0 1 1 1 0 Ring finger domain SPC12 PF06645.13 EDN06434.1 - 1.8e-27 95.2 0.3 2.2e-27 94.9 0.3 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) Phage_holin_2_3 PF16080.5 EDN06434.1 - 0.12 12.1 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage holin family HP1 APH PF01636.23 EDN06435.1 - 2.1e-05 24.6 0.8 0.00037 20.5 0.1 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 EDN06435.1 - 0.015 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain DUF1679 PF07914.11 EDN06435.1 - 0.092 11.6 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) SMI1_KNR4 PF09346.10 EDN06437.1 - 1.8e-21 77.0 0.0 4e-21 75.8 0.0 1.6 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Dicty_REP PF05086.12 EDN06437.1 - 0.32 8.9 6.6 0.42 8.5 6.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AJAP1_PANP_C PF15298.6 EDN06437.1 - 1 9.6 9.7 2 8.6 9.7 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Thioredoxin PF00085.20 EDN06439.1 - 0.041 13.9 0.0 0.079 13.0 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin UPF0370 PF13980.6 EDN06441.1 - 0.11 12.6 0.1 0.47 10.5 0.0 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0370) DUF2431 PF10354.9 EDN06442.1 - 1.3e-57 194.8 0.0 3.5e-42 144.5 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF2431) CLTH PF10607.9 EDN06443.1 - 5.8e-36 123.6 0.0 1.1e-35 122.7 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EDN06443.1 - 0.033 14.2 0.0 0.079 12.9 0.0 1.7 1 0 0 1 1 1 0 LisH DNA_meth_N PF18284.1 EDN06443.1 - 0.052 13.5 0.3 1.5 8.7 0.0 2.6 2 0 0 2 2 2 0 DNA methylase N-terminal domain zf-Di19 PF05605.12 EDN06443.1 - 0.097 13.0 0.3 0.21 11.9 0.3 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding CaMBD PF02888.16 EDN06443.1 - 0.15 12.3 1.8 2.9 8.2 0.1 2.4 2 0 0 2 2 2 0 Calmodulin binding domain TruB_C_2 PF16198.5 EDN06444.1 - 2.5e-23 82.0 1.5 4.4e-23 81.2 1.5 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EDN06444.1 - 1.3e-20 74.3 0.2 1.5e-17 64.3 0.2 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EDN06444.1 - 3.1e-20 71.9 1.3 5.8e-20 71.0 1.3 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EDN06444.1 - 0.0031 17.8 0.0 0.0078 16.5 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain Med19 PF10278.9 EDN06444.1 - 1.8 8.5 12.9 3.8 7.4 12.9 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DER1 PF04511.15 EDN06445.1 - 9.2e-24 84.4 3.9 1.1e-23 84.1 3.9 1.1 1 0 0 1 1 1 1 Der1-like family MaoC_dehydratas PF01575.19 EDN06446.1 - 2.4e-05 23.9 0.0 7.7e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain PDT PF00800.18 EDN06447.1 - 1.5e-55 187.9 0.0 2e-55 187.5 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EDN06447.1 - 4.7e-06 26.3 0.0 1.4e-05 24.7 0.0 1.9 1 1 0 1 1 1 1 ACT domain eRF1_2 PF03464.15 EDN06448.1 - 2.4e-48 163.8 0.1 4.2e-48 163.0 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDN06448.1 - 1.9e-39 134.7 0.2 3.9e-39 133.6 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EDN06448.1 - 4.3e-21 75.3 0.0 7.1e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EDN06448.1 - 4.1e-10 40.0 0.0 8.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EDN06448.1 - 1e-08 35.6 0.0 1.6e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor YbjQ_1 PF01906.17 EDN06449.1 - 1.1e-24 87.0 0.1 1.5e-24 86.6 0.1 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding DUF937 PF06078.11 EDN06449.1 - 0.056 14.0 0.1 0.089 13.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF937) Aa_trans PF01490.18 EDN06450.1 - 3.9e-48 164.2 31.3 9.7e-28 97.0 13.0 2.3 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein MerC PF03203.14 EDN06450.1 - 0.012 16.0 2.5 0.012 16.0 2.5 3.3 3 2 0 3 3 3 0 MerC mercury resistance protein Bmt2 PF11968.8 EDN06451.1 - 1.2e-99 332.6 0.0 1.4e-99 332.4 0.0 1.0 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 RhlB PF12300.8 EDN06451.1 - 0.11 12.6 1.8 0.19 11.8 1.8 1.4 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Ribosomal_L23eN PF03939.13 EDN06452.1 - 6.3e-29 99.9 9.0 6.3e-29 99.9 9.0 1.9 3 0 0 3 3 3 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EDN06452.1 - 3.6e-14 52.9 4.8 6.6e-14 52.1 2.6 2.0 2 0 0 2 2 2 1 Ribosomal protein L23 DUF3326 PF11805.8 EDN06452.1 - 0.037 12.9 0.1 0.042 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) PHA-1 PF06542.11 EDN06452.1 - 0.053 12.4 0.6 0.071 11.9 0.6 1.1 1 0 0 1 1 1 0 Regulator protein PHA-1 zf-Tim10_DDP PF02953.15 EDN06453.1 - 7.4e-23 80.0 1.1 8.8e-23 79.7 1.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger G10 PF01125.17 EDN06454.1 - 7.7e-41 139.3 0.4 8.3e-41 139.2 0.4 1.0 1 0 0 1 1 1 1 G10 protein PT PF04886.12 EDN06456.1 - 2.7e-05 23.6 29.5 3.7e+02 0.8 29.5 2.5 1 1 0 1 1 1 0 PT repeat BTB PF00651.31 EDN06456.1 - 7.7e-05 22.9 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.25 EDN06458.1 - 4.9e-19 68.7 0.0 4.4e-10 39.4 0.0 2.9 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06458.1 - 1.4e-11 44.2 0.1 0.0012 18.2 0.0 3.6 4 0 0 4 4 4 3 Protein tyrosine kinase Kdo PF06293.14 EDN06458.1 - 2.8e-05 23.6 0.0 0.0091 15.4 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN06458.1 - 0.07 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN06458.1 - 0.12 11.7 0.0 22 4.2 0.0 2.9 3 0 0 3 3 3 0 Kinase-like DUF4712 PF15830.5 EDN06460.1 - 0.052 13.2 0.4 0.09 12.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4712) Myb_DNA-binding PF00249.31 EDN06461.1 - 1.9e-11 44.0 0.0 3.3e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN06461.1 - 2.7e-05 24.3 0.1 9e-05 22.6 0.1 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-C2H2 PF00096.26 EDN06461.1 - 0.00032 21.0 3.6 0.27 11.8 0.2 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDN06461.1 - 0.19 12.1 1.1 1.1 9.6 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDN06461.1 - 0.23 12.4 8.4 0.49 11.4 0.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger IBR PF01485.21 EDN06461.1 - 0.91 9.8 6.7 0.23 11.7 2.5 2.2 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain RasGEF PF00617.19 EDN06462.1 - 0.073 13.3 0.1 7.7 6.7 0.0 3.0 2 1 0 2 2 2 0 RasGEF domain Inhibitor_I36 PF03995.13 EDN06462.1 - 0.086 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor family I36 RVT_1 PF00078.27 EDN06463.1 - 1.7e-37 129.1 0.0 3.2e-37 128.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN06463.1 - 1.6e-24 86.0 0.2 5.8e-24 84.2 0.2 2.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN06463.1 - 5.6e-12 46.0 0.0 1.4e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN06463.1 - 3.2e-05 23.7 0.2 0.00038 20.3 0.0 2.4 2 0 0 2 2 2 1 Reverse transcriptase-like Exo_endo_phos PF03372.23 EDN06463.1 - 6.5e-05 22.6 0.1 0.0002 20.9 0.1 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PuR_N PF09182.10 EDN06463.1 - 0.0044 16.9 0.1 0.037 14.0 0.1 2.5 2 0 0 2 2 2 1 Bacterial purine repressor, N-terminal zf-CCHC PF00098.23 EDN06463.1 - 0.011 15.8 4.6 0.033 14.3 4.6 1.8 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 EDN06465.1 - 4e-36 124.6 0.0 7.7e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN06465.1 - 9.2e-27 93.2 0.0 2.9e-26 91.6 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN06465.1 - 1.1e-12 48.4 0.0 5e-12 46.2 0.0 2.3 1 0 0 1 1 1 1 RNase H HALZ PF02183.18 EDN06465.1 - 0.00031 20.9 0.4 0.00076 19.7 0.4 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper Exo_endo_phos PF03372.23 EDN06465.1 - 0.0016 18.0 0.1 0.0038 16.8 0.1 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ATG16 PF08614.11 EDN06465.1 - 0.021 15.1 0.6 0.088 13.0 0.6 2.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Spc29 PF17082.5 EDN06465.1 - 0.031 14.1 0.6 0.096 12.5 0.1 2.0 2 0 0 2 2 2 0 Spindle Pole Component 29 RVT_3 PF13456.6 EDN06465.1 - 0.071 12.9 0.1 0.25 11.2 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like YabA PF06156.13 EDN06465.1 - 0.091 13.4 0.2 0.32 11.7 0.2 1.9 1 0 0 1 1 1 0 Initiation control protein YabA zf-RVT PF13966.6 EDN06465.1 - 0.12 13.1 0.1 0.44 11.3 0.1 2.0 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase TSC22 PF01166.18 EDN06465.1 - 0.19 12.1 1.3 0.62 10.4 0.4 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family zf-CSL PF05207.13 EDN06466.1 - 0.021 14.5 0.2 0.024 14.3 0.2 1.2 1 0 0 1 1 1 0 CSL zinc finger AAA PF00004.29 EDN06467.1 - 0.00076 19.9 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDN06467.1 - 0.017 15.7 0.0 0.026 15.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDN06467.1 - 0.025 14.4 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDN06467.1 - 0.028 14.7 0.0 0.063 13.5 0.0 1.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDN06467.1 - 0.048 13.4 0.2 0.071 12.8 0.2 1.1 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 EDN06467.1 - 0.086 12.4 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDN06467.1 - 0.28 10.6 0.3 0.44 10.0 0.3 1.2 1 0 0 1 1 1 0 PhoH-like protein TIP49 PF06068.13 EDN06467.1 - 0.3 10.3 0.1 0.4 9.8 0.1 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain ClpB_D2-small PF10431.9 EDN06469.1 - 0.12 12.4 0.1 7 6.8 0.0 2.3 1 1 1 2 2 2 0 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EDN06472.1 - 2.3e-05 24.8 0.0 5e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SET_assoc PF11767.8 EDN06472.1 - 0.063 12.9 0.0 0.2 11.3 0.0 1.8 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DivIC PF04977.15 EDN06472.1 - 0.13 12.1 0.2 0.74 9.6 0.0 2.2 2 0 0 2 2 2 0 Septum formation initiator Pkinase_fungal PF17667.1 EDN06473.1 - 1.4e-126 422.6 0.0 1.7e-126 422.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase SurA_N_3 PF13624.6 EDN06473.1 - 0.017 14.9 0.1 0.03 14.1 0.1 1.3 1 0 0 1 1 1 0 SurA N-terminal domain DUF3435 PF11917.8 EDN06474.1 - 4.2e-163 543.1 0.6 5.5e-163 542.7 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN06474.1 - 1.9e-05 24.5 0.1 0.0033 17.2 0.0 2.7 2 1 0 2 2 2 2 Phage integrase family DUF3435 PF11917.8 EDN06475.1 - 1.6e-145 485.2 0.0 2.3e-145 484.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DUF3723 PF12520.8 EDN06477.1 - 2.7e-166 554.2 1.5 5.1e-166 553.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3723) RasGAP_C PF03836.15 EDN06477.1 - 0.54 10.4 2.1 1 9.5 2.1 1.4 1 0 0 1 1 1 0 RasGAP C-terminus DUF1480 PF07351.13 EDN06478.1 - 0.085 13.1 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1480) Helo_like_N PF17111.5 EDN06479.1 - 9.5e-30 103.5 11.2 4.2e-13 49.1 0.9 3.3 2 1 1 3 3 3 3 Fungal N-terminal domain of STAND proteins APH PF01636.23 EDN06479.1 - 5.9e-07 29.7 1.1 1.7e-06 28.2 1.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN06479.1 - 0.0019 17.8 0.1 0.0077 15.8 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase PRESAN PF09687.10 EDN06479.1 - 0.014 15.9 0.0 0.041 14.4 0.0 1.7 1 0 0 1 1 1 0 Plasmodium RESA N-terminal Pneumo_phosprot PF02478.16 EDN06479.1 - 0.043 13.4 0.0 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Pneumovirus phosphoprotein zf-C2H2_4 PF13894.6 EDN06480.1 - 0.069 14.0 2.5 6.3 7.9 0.5 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2721 PF11026.8 EDN06480.1 - 0.32 10.9 2.2 1.6 8.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) RasGEF PF00617.19 EDN06481.1 - 0.00089 19.5 0.0 0.0016 18.7 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain HTH_12 PF08461.10 EDN06481.1 - 0.1 12.6 0.1 1 9.3 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain Pkinase_Tyr PF07714.17 EDN06483.1 - 2.6e-16 59.7 0.2 7.4e-07 28.7 0.0 4.0 1 1 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 EDN06483.1 - 2.1e-12 47.0 0.0 3.8e-08 33.0 0.0 3.0 2 2 0 2 2 2 2 Protein kinase domain DUF1691 PF07950.11 EDN06483.1 - 0.067 13.9 0.2 21 5.9 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1691) AAA PF00004.29 EDN06485.1 - 4e-17 62.9 0.0 7.8e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN06485.1 - 1.2e-05 25.8 0.2 2.8e-05 24.6 0.1 1.7 2 0 0 2 2 1 1 AAA ATPase domain AAA_5 PF07728.14 EDN06485.1 - 8.8e-05 22.5 0.1 0.00063 19.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EDN06485.1 - 0.00035 21.1 0.0 0.0014 19.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN06485.1 - 0.00045 20.5 0.9 0.0044 17.3 0.0 2.8 3 1 1 4 4 3 1 AAA domain RuvB_N PF05496.12 EDN06485.1 - 0.0011 18.7 0.3 0.019 14.7 0.0 2.8 3 1 1 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDN06485.1 - 0.057 13.7 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN06485.1 - 0.066 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDN06485.1 - 0.067 12.5 0.0 0.52 9.6 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin T2SSE PF00437.20 EDN06485.1 - 0.068 12.2 0.0 0.17 10.9 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_3 PF07726.11 EDN06485.1 - 0.086 12.7 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EDN06485.1 - 0.099 13.0 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EDN06485.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EDN06485.1 - 0.11 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EDN06485.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_17 PF13207.6 EDN06485.1 - 0.14 12.6 0.0 0.45 10.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain Aegerolysin PF06355.13 EDN06485.1 - 0.16 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Aegerolysin TIP49 PF06068.13 EDN06485.1 - 0.17 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_30 PF13604.6 EDN06485.1 - 0.17 11.6 0.1 0.45 10.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 EDN06487.1 - 9.5e-26 90.7 0.0 2.5e-13 50.0 0.0 2.9 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06487.1 - 4.9e-17 62.1 0.0 1.9e-11 43.8 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EDN06487.1 - 1.4e-07 31.7 1.9 0.0001 22.3 0.1 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN06487.1 - 3.9e-06 26.6 0.4 3.8e-05 23.4 0.1 2.5 3 0 0 3 3 3 1 Choline/ethanolamine kinase RIO1 PF01163.22 EDN06487.1 - 0.0049 16.5 0.0 3.3 7.3 0.0 2.3 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.14 EDN06487.1 - 0.005 16.2 0.0 0.23 10.8 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN06487.1 - 0.15 10.8 0.0 0.33 9.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EDN06487.1 - 0.24 10.3 0.0 0.24 10.3 0.0 1.8 3 0 0 3 3 3 0 Haspin like kinase domain SOG2 PF10428.9 EDN06488.1 - 0.0089 15.3 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein ATG16 PF08614.11 EDN06492.1 - 0.023 14.9 0.0 0.026 14.7 0.0 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Uso1_p115_C PF04871.13 EDN06492.1 - 0.031 14.6 0.1 0.039 14.3 0.1 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Pkinase PF00069.25 EDN06493.1 - 5.2e-06 26.0 0.0 7.5e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN06493.1 - 0.00061 19.2 0.0 0.00095 18.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN06493.1 - 0.018 15.0 0.2 0.035 14.0 0.2 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Myb_DNA-bind_6 PF13921.6 EDN06495.1 - 0.0086 16.3 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN06495.1 - 0.014 15.6 0.2 0.032 14.4 0.2 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Pinin_SDK_N PF04697.13 EDN06495.1 - 1.9 9.1 7.2 1.3 9.7 4.5 2.1 1 1 1 2 2 2 0 pinin/SDK conserved region Myb_DNA-binding PF00249.31 EDN06496.1 - 0.00019 21.5 0.1 0.00044 20.4 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain PBP1_TM PF14812.6 EDN06496.1 - 0.019 15.3 4.7 0.048 14.0 4.7 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AA_kinase PF00696.28 EDN06498.1 - 1e-38 133.3 0.1 1.6e-38 132.6 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 EDN06498.1 - 1.9e-08 33.9 0.2 1.2e-05 25.0 0.0 3.0 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.6 EDN06498.1 - 5.2e-07 29.3 0.3 0.00015 21.5 0.0 2.8 2 0 0 2 2 2 2 ACT domain SapB_1 PF05184.15 EDN06498.1 - 0.02 14.9 0.2 0.039 14.0 0.2 1.5 1 0 0 1 1 1 0 Saposin-like type B, region 1 Peptidase_C78 PF07910.13 EDN06499.1 - 3.6e-62 209.6 0.0 4.1e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C78 AAA_18 PF13238.6 EDN06500.1 - 1.7e-24 86.8 0.1 3.2e-24 86.0 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EDN06500.1 - 6.8e-08 33.0 0.0 1.9e-07 31.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 EDN06500.1 - 0.0002 21.8 0.0 0.00044 20.7 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDN06500.1 - 0.00098 19.4 0.0 0.0024 18.1 0.0 1.7 2 1 0 2 2 2 1 AAA domain Hydin_ADK PF17213.3 EDN06500.1 - 0.0018 18.6 0.0 0.0026 18.0 0.0 1.2 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain ADK PF00406.22 EDN06500.1 - 0.0031 17.6 0.1 0.014 15.5 0.0 2.0 2 1 0 2 2 2 1 Adenylate kinase AAA_33 PF13671.6 EDN06500.1 - 0.0044 17.2 0.0 0.0079 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EDN06500.1 - 0.0057 16.6 0.1 0.017 15.0 0.0 1.8 2 0 0 2 2 2 1 NTPase AAA_22 PF13401.6 EDN06500.1 - 0.0083 16.4 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDN06500.1 - 0.017 14.6 0.0 0.036 13.5 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 RNA_helicase PF00910.22 EDN06500.1 - 0.02 15.3 0.0 0.038 14.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EDN06500.1 - 0.026 14.9 0.0 0.043 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 EDN06500.1 - 0.026 14.6 0.0 0.072 13.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN06500.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EDN06500.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Ham1p_like PF01725.16 EDN06501.1 - 2.7e-29 102.4 0.0 3.1e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF1918 PF08940.11 EDN06501.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Myosin_head PF00063.21 EDN06502.1 - 8.1e-204 678.7 3.6 2.9e-159 531.4 7.5 2.7 1 1 1 2 2 2 2 Myosin head (motor domain) DIL PF01843.19 EDN06502.1 - 3e-26 91.7 2.8 3e-26 91.7 2.8 2.9 2 1 0 2 2 2 1 DIL domain IQ PF00612.27 EDN06502.1 - 1.3e-12 46.3 28.6 4.3e-05 22.9 0.7 6.9 6 0 0 6 6 6 4 IQ calmodulin-binding motif AAA_16 PF13191.6 EDN06502.1 - 0.001 19.5 2.9 0.007 16.8 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain GAS PF13851.6 EDN06502.1 - 0.0051 16.2 29.0 0.11 11.8 12.7 2.6 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Myosin_N PF02736.19 EDN06502.1 - 0.019 14.8 1.0 0.052 13.4 1.0 1.8 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EDN06502.1 - 0.048 13.9 3.9 0.073 13.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain HSF_DNA-bind PF00447.17 EDN06502.1 - 0.11 13.2 1.7 0.6 10.8 1.2 2.4 2 0 0 2 2 2 0 HSF-type DNA-binding EzrA PF06160.12 EDN06502.1 - 0.13 10.4 17.8 0.12 10.5 3.1 2.5 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA CbiA PF01656.23 EDN06502.1 - 0.14 12.2 0.2 1.8 8.6 0.1 2.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.22 EDN06502.1 - 0.17 12.3 0.1 0.97 9.9 0.0 2.4 2 0 0 2 2 1 0 RNA helicase Spc7 PF08317.11 EDN06502.1 - 0.18 10.7 23.8 0.77 8.6 22.6 2.2 1 1 0 1 1 1 0 Spc7 kinetochore protein Phage_GP20 PF06810.11 EDN06502.1 - 0.31 10.8 16.6 0.04 13.7 3.6 2.6 1 1 1 2 2 2 0 Phage minor structural protein GP20 ATG16 PF08614.11 EDN06502.1 - 0.39 10.9 31.8 4.5 7.4 15.2 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) AAA PF00004.29 EDN06502.1 - 0.53 10.7 2.0 45 4.5 0.0 4.0 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) FlaC_arch PF05377.11 EDN06502.1 - 0.65 10.4 12.5 0.65 10.4 0.4 4.5 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Aida_N PF08910.10 EDN06502.1 - 1.3 9.4 5.1 20 5.7 1.9 3.1 1 1 1 2 2 2 0 Aida N-terminus Herpes_UL6 PF01763.16 EDN06502.1 - 1.4 7.4 14.9 0.46 8.9 7.1 2.8 2 1 1 3 3 3 0 Herpesvirus UL6 like Cortex-I_coil PF09304.10 EDN06502.1 - 1.6 9.0 21.1 1.3 9.3 4.7 2.8 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF4795 PF16043.5 EDN06502.1 - 4.7 6.7 17.3 2.7 7.5 7.9 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) KASH_CCD PF14662.6 EDN06502.1 - 4.9 6.9 29.4 0.06 13.2 7.5 2.8 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Baculo_PEP_C PF04513.12 EDN06502.1 - 5.2 7.1 12.1 0.39 10.8 5.3 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF484 PF04340.12 EDN06502.1 - 9.7 5.8 12.1 15 5.2 10.6 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF484 NAP PF00956.18 EDN06503.1 - 1.3e-94 316.4 6.2 1.7e-94 316.0 6.2 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) P5-ATPase PF12409.8 EDN06504.1 - 6.9e-37 126.3 0.1 1.3e-36 125.5 0.1 1.5 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EDN06504.1 - 6.8e-19 68.1 0.0 5.2e-16 58.7 0.0 2.3 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase PF00702.26 EDN06504.1 - 1.3e-14 55.0 0.0 4.6e-11 43.4 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDN06504.1 - 0.02 15.0 0.0 0.052 13.6 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) NADH_B2 PF14813.6 EDN06505.1 - 0.024 14.4 0.1 0.024 14.4 0.1 1.1 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 Pkinase PF00069.25 EDN06506.1 - 1.4e-26 93.5 0.0 2.3e-15 56.7 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06506.1 - 1.2e-09 37.9 0.0 3.2e-07 29.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase 2-Hacid_dh_C PF02826.19 EDN06508.1 - 4.9e-52 175.9 0.0 7.9e-52 175.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN06508.1 - 3.2e-37 127.2 0.0 4.2e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 EDN06508.1 - 7.9e-05 22.3 0.0 0.00019 21.1 0.0 1.7 1 0 0 1 1 1 1 ACT domain NAD_binding_2 PF03446.15 EDN06508.1 - 9e-05 22.7 0.2 0.0002 21.6 0.2 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EDN06508.1 - 0.002 18.0 4.3 3 7.7 0.5 4.0 3 1 1 4 4 4 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EDN06508.1 - 0.0068 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EDN06508.1 - 0.0072 15.9 0.1 0.031 13.8 0.0 2.0 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 EDN06508.1 - 0.025 15.1 0.0 0.08 13.4 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain DUF1780 PF08682.10 EDN06508.1 - 0.03 14.0 0.0 0.78 9.4 0.0 2.2 2 0 0 2 2 2 0 Putative endonuclease, protein of unknown function (DUF1780) tRNA-synt_2b PF00587.25 EDN06509.1 - 3.3e-30 105.4 0.1 1.1e-29 103.7 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDN06509.1 - 4.8e-09 36.4 14.9 4.8e-09 36.4 14.9 2.7 2 1 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain PFL-like PF02901.15 EDN06510.1 - 0.0018 17.0 0.9 0.0026 16.5 0.9 1.2 1 0 0 1 1 1 1 Pyruvate formate lyase-like LAT PF15234.6 EDN06510.1 - 0.079 12.7 0.4 0.094 12.4 0.4 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells DUF3746 PF12562.8 EDN06510.1 - 0.11 12.5 0.6 0.23 11.4 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) Sipho_Gp157 PF05565.11 EDN06510.1 - 0.12 12.4 3.5 0.17 11.9 3.5 1.1 1 0 0 1 1 1 0 Siphovirus Gp157 HalX PF08663.10 EDN06510.1 - 0.28 11.5 6.5 2.4 8.5 0.7 2.4 1 1 1 2 2 2 0 HalX domain PRP1_N PF06424.12 EDN06510.1 - 6.1 7.2 7.8 34 4.8 7.8 2.0 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal CbiK PF06180.11 EDN06511.1 - 0.082 12.2 0.2 0.14 11.5 0.1 1.2 1 1 0 1 1 1 0 Cobalt chelatase (CbiK) Ras PF00071.22 EDN06512.1 - 2.6e-44 150.7 0.4 2.9e-44 150.5 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN06512.1 - 2.1e-15 57.0 0.1 2.9e-15 56.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN06512.1 - 2.1e-08 33.8 0.0 2.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDN06512.1 - 1.7e-05 24.9 0.0 2.3e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDN06512.1 - 7.9e-05 22.3 0.0 0.0011 18.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDN06512.1 - 0.0051 16.3 0.0 0.0058 16.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDN06512.1 - 0.026 14.4 0.0 2.5 8.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase WAPL PF07814.13 EDN06513.1 - 1.1e-07 30.9 0.3 1.9e-07 30.3 0.1 1.4 2 0 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin WAPL PF07814.13 EDN06514.1 - 8.6e-24 84.0 0.0 1.5e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin UPRTase PF14681.6 EDN06515.1 - 4.9e-59 199.2 0.0 3.6e-39 134.4 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Flu_C_NS1 PF03506.13 EDN06515.1 - 0.095 12.7 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Elf1 PF05129.13 EDN06516.1 - 9e-26 89.7 0.6 1.4e-25 89.1 0.6 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Peptidase_U32 PF01136.19 EDN06516.1 - 0.0065 15.6 0.0 0.0073 15.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family U32 zf-Sec23_Sec24 PF04810.15 EDN06516.1 - 0.2 11.7 3.0 5.1 7.2 1.0 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger AATase PF07247.12 EDN06517.1 - 0.00075 18.2 0.5 0.022 13.3 0.1 2.0 2 0 0 2 2 2 2 Alcohol acetyltransferase Pilin_GH PF16734.5 EDN06518.1 - 0.074 13.4 0.0 0.087 13.1 0.0 1.1 1 0 0 1 1 1 0 Type IV pilin-like G and H, putative RT_RNaseH PF17917.1 EDN06519.1 - 3.6e-08 33.6 0.2 4.5e-08 33.3 0.2 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN06519.1 - 2.3e-05 24.4 0.1 6e-05 23.0 0.0 1.7 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase Cnd1_N PF12922.7 EDN06521.1 - 1.3e-43 148.7 0.2 4.2e-43 147.1 0.2 1.9 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EDN06521.1 - 2.7e-38 131.6 4.8 1.6e-22 80.3 0.8 4.1 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN06521.1 - 1.3e-11 44.7 0.9 8.8e-05 22.8 0.0 4.4 3 2 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EDN06521.1 - 7.9e-11 41.3 7.0 0.04 14.2 0.0 6.4 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 EDN06521.1 - 5.3e-05 23.6 6.1 0.21 12.2 0.1 5.3 5 1 1 6 6 6 1 HEAT-like repeat RTP1_C1 PF10363.9 EDN06521.1 - 0.0047 17.1 6.8 0.048 13.8 0.0 4.9 6 1 0 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 EDN06521.1 - 0.0099 15.1 8.2 0.01 15.1 1.8 3.7 3 2 1 4 4 4 1 Nuclear condensing complex subunits, C-term domain Cohesin_HEAT PF12765.7 EDN06521.1 - 0.03 14.6 0.1 12 6.3 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion HypF_C PF17788.1 EDN06521.1 - 0.5 11.1 2.2 4.6 8.0 0.1 3.0 3 0 0 3 3 3 0 HypF Kae1-like domain MPS-4 PF17523.2 EDN06522.1 - 0.52 10.5 6.6 1 9.5 6.6 1.6 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 zf-LITAF-like PF10601.9 EDN06522.1 - 1.7 9.0 6.7 3.1 8.2 6.7 1.4 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain YabA PF06156.13 EDN06523.1 - 0.63 10.7 5.1 2.1 9.0 5.1 1.9 1 1 0 1 1 1 0 Initiation control protein YabA OrsD PF12013.8 EDN06524.1 - 3.6e-19 69.3 1.1 1.3e-18 67.5 0.1 2.2 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D REV1_C PF16727.5 EDN06527.1 - 0.065 13.6 0.6 0.15 12.4 0.1 1.9 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain APG5 PF04106.12 EDN06527.1 - 0.13 11.9 0.1 0.29 10.7 0.1 1.5 2 0 0 2 2 2 0 Autophagy protein Apg5 E7 PF00527.18 EDN06527.1 - 2.8 8.2 10.4 2.3 8.5 3.3 2.4 2 0 0 2 2 2 0 E7 protein, Early protein OrsD PF12013.8 EDN06530.1 - 0.00079 19.9 1.6 0.0016 18.9 0.1 2.3 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D Exo_endo_phos_2 PF14529.6 EDN06533.1 - 4.8e-15 55.5 0.0 9.9e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN06533.1 - 2e-05 24.2 0.0 4.6e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family PRKCSH PF07915.13 EDN06534.1 - 1.8e-15 57.7 0.2 4.9e-15 56.3 0.1 1.7 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein DUF751 PF05421.11 EDN06535.1 - 0.11 13.2 0.1 0.11 13.2 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF751) zinc_ribbon_2 PF13240.6 EDN06535.1 - 0.18 11.6 0.7 16 5.4 0.5 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Sod_Cu PF00080.20 EDN06536.1 - 2e-09 37.7 0.0 3.3e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Choline_kinase PF01633.20 EDN06538.1 - 7e-47 159.8 0.0 1.2e-45 155.7 0.0 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EDN06538.1 - 1.4e-11 44.8 0.5 2.5e-11 43.9 0.1 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Metallophos PF00149.28 EDN06539.1 - 1.1e-07 32.6 1.8 1.4e-07 32.3 1.8 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PSI PF01437.25 EDN06540.1 - 4.5e-05 23.9 8.8 6.9e-05 23.3 8.8 1.3 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 EDN06540.1 - 0.024 14.4 10.7 0.041 13.6 10.7 1.3 1 0 0 1 1 1 0 Integrin plexin domain zf-C2H2_10 PF16588.5 EDN06542.1 - 0.0069 16.1 3.0 0.012 15.3 3.0 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger Retrotran_gag_3 PF14244.6 EDN06542.1 - 0.029 14.2 0.1 0.06 13.2 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN06542.1 - 0.08 12.6 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) peroxidase PF00141.23 EDN06544.1 - 8.5e-12 45.2 0.0 1.5e-11 44.4 0.0 1.4 1 1 0 1 1 1 1 Peroxidase OrsD PF12013.8 EDN06545.1 - 2.9e-38 130.8 5.5 2.9e-38 130.8 5.5 2.0 2 1 1 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN06545.1 - 0.0056 16.4 3.5 0.13 12.0 1.5 2.6 2 0 0 2 2 2 1 C2H2-type zinc-finger domain DUF2225 PF09986.9 EDN06545.1 - 0.032 14.0 0.2 0.96 9.1 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF4298 PF14131.6 EDN06545.1 - 0.13 12.3 1.3 12 5.9 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Helicase_C PF00271.31 EDN06546.1 - 2.6e-15 56.7 0.1 5.8e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DDE_Tnp_1_7 PF13843.6 EDN06548.1 - 2.6e-06 27.0 0.0 2.6e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Transposase IS4 DUF865 PF05906.11 EDN06550.1 - 0.59 10.0 10.6 84 3.1 0.3 5.6 2 1 3 5 5 5 0 Herpesvirus-7 repeat of unknown function (DUF865) CDC37_C PF08564.10 EDN06553.1 - 0.03 14.5 0.2 0.039 14.1 0.2 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain Ntox46 PF15538.6 EDN06555.1 - 0.63 10.0 3.0 2.4 8.1 0.2 3.0 1 1 2 4 4 4 0 Bacterial toxin 46 EndoU_bacteria PF14436.6 EDN06555.1 - 0.72 10.2 2.3 1.9 8.8 0.5 2.6 1 1 1 2 2 2 0 Bacterial EndoU nuclease Pkinase_fungal PF17667.1 EDN06556.1 - 2.5e-98 329.6 0.2 3.1e-91 306.2 0.0 2.0 1 1 1 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 EDN06556.1 - 9.9e-08 31.7 0.0 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06556.1 - 0.033 13.5 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN06556.1 - 0.054 13.4 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDN06556.1 - 0.12 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family DUF4658 PF15555.6 EDN06557.1 - 0.21 11.7 1.0 3.5 7.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) zf_PR_Knuckle PF18445.1 EDN06559.1 - 0.44 10.4 0.2 0.44 10.4 0.2 2.2 2 0 0 2 2 2 0 PR zinc knuckle motif Med3 PF11593.8 EDN06559.1 - 8 5.5 6.0 1.1 8.4 1.9 1.5 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Oxysterol_BP PF01237.18 EDN06560.1 - 1.6e-45 155.5 0.0 2e-45 155.3 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein RVT_1 PF00078.27 EDN06561.1 - 6.3e-16 58.6 0.0 9.5e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_7 PF12775.7 EDN06561.1 - 0.18 11.3 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RVT_2 PF07727.14 EDN06563.1 - 0.00024 20.8 0.0 0.00035 20.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 EDN06564.1 - 1.2e-44 152.8 0.0 1.4e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HLH PF00010.26 EDN06565.1 - 4.2e-10 39.4 1.0 1.7e-09 37.5 0.9 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PBP1_TM PF14812.6 EDN06566.1 - 0.84 10.0 5.4 9.1 6.7 0.1 3.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SDF PF00375.18 EDN06567.1 - 1.6e-22 80.1 2.2 2.1e-22 79.7 2.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family CAAD PF14159.6 EDN06567.1 - 0.005 16.7 2.3 0.0058 16.4 0.4 2.1 1 1 1 2 2 2 1 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF760 PF05542.11 EDN06567.1 - 0.14 12.5 0.0 17 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF760) DUF805 PF05656.14 EDN06567.1 - 0.6 10.5 4.7 0.17 12.3 1.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF805) UPF0052 PF01933.18 EDN06569.1 - 2.4e-32 112.4 0.0 2.7e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DDE_1 PF03184.19 EDN06570.1 - 0.00072 19.2 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 EDN06571.1 - 7e-23 81.2 0.0 1.2e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN06571.1 - 1.2e-05 25.2 0.0 0.00074 19.3 0.0 3.0 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06571.1 - 0.0011 18.9 0.2 0.0047 16.9 0.0 2.2 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN06571.1 - 0.022 14.5 0.5 0.022 14.5 0.5 2.1 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN06571.1 - 0.036 13.6 0.0 0.087 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) AIF_C PF14721.6 EDN06571.1 - 0.069 13.5 0.7 0.14 12.6 0.7 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Myb_DNA-bind_6 PF13921.6 EDN06573.1 - 5.4e-05 23.4 0.4 5.4e-05 23.4 0.4 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN06573.1 - 0.0061 16.7 1.6 0.013 15.7 1.6 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_2 PF16496.5 EDN06573.1 - 0.0093 14.9 3.8 0.013 14.4 3.8 1.3 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal zf-C2H2_10 PF16588.5 EDN06574.1 - 0.01 15.5 3.0 0.019 14.7 3.0 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger Retrotran_gag_3 PF14244.6 EDN06574.1 - 0.04 13.7 0.1 0.092 12.6 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN06574.1 - 0.11 12.2 0.1 0.22 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Phage_min_cap2 PF06152.11 EDN06574.1 - 0.2 10.5 1.7 0.33 9.8 1.7 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 ORF_12_N PF18042.1 EDN06576.1 - 0.012 16.0 0.4 0.025 15.0 0.4 1.5 1 0 0 1 1 1 0 ORF 12 gene product N-terminal DUF5039 PF16442.5 EDN06576.1 - 0.066 12.7 0.2 0.11 12.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) Ebp2 PF05890.12 EDN06577.1 - 7.1e-75 252.0 8.2 9.2e-75 251.6 8.2 1.1 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 RVT_1 PF00078.27 EDN06578.1 - 1.3e-29 103.3 0.0 1.7e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E7 PF00527.18 EDN06580.1 - 1.8 8.8 7.6 0.44 10.8 2.7 2.4 2 0 0 2 2 2 0 E7 protein, Early protein CNH PF00780.22 EDN06582.1 - 2.3e-51 175.0 0.0 2.8e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 CNH domain Pkinase_fungal PF17667.1 EDN06586.1 - 1.8e-33 115.9 0.0 1.9e-33 115.9 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase RVT_2 PF07727.14 EDN06588.1 - 1.4e-43 149.3 0.0 2.2e-43 148.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06588.1 - 0.0014 18.8 0.1 0.0051 17.0 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN06588.1 - 0.029 14.1 3.0 0.054 13.2 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN06588.1 - 0.031 14.1 0.0 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN06588.1 - 0.083 12.7 0.1 0.27 11.1 0.1 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Pinin_SDK_memA PF04696.13 EDN06589.1 - 0.014 15.4 7.9 0.014 15.4 7.9 1.7 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Peptidase_S30 PF01577.16 EDN06589.1 - 0.05 13.2 2.4 0.15 11.7 1.6 1.8 2 0 0 2 2 2 0 Potyvirus P1 protease kleA_kleC PF17383.2 EDN06589.1 - 0.078 13.3 11.6 0.078 13.3 5.0 2.4 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A SurA_N_3 PF13624.6 EDN06589.1 - 0.11 12.2 2.3 0.17 11.7 2.3 1.2 1 0 0 1 1 1 0 SurA N-terminal domain YtxH PF12732.7 EDN06589.1 - 0.26 11.8 0.7 0.55 10.8 0.7 1.5 1 0 0 1 1 1 0 YtxH-like protein DEAD PF00270.29 EDN06590.1 - 4.3e-35 121.0 0.0 5.4e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 EDN06590.1 - 0.0042 16.5 0.0 0.0081 15.5 0.0 1.4 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 EDN06590.1 - 0.033 14.2 0.0 0.049 13.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit YabA PF06156.13 EDN06591.1 - 0.12 13.1 0.1 0.14 12.9 0.1 1.1 1 0 0 1 1 1 0 Initiation control protein YabA RVT_1 PF00078.27 EDN06592.1 - 3.1e-25 89.0 0.0 4.5e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRELI PF04707.14 EDN06593.1 - 1.7e-44 151.4 0.5 2.1e-44 151.1 0.5 1.1 1 0 0 1 1 1 1 PRELI-like family TPR_12 PF13424.6 EDN06593.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Mpp10 PF04006.12 EDN06594.1 - 6.7e-05 21.5 1.8 0.00079 18.0 1.8 1.9 1 1 0 1 1 1 1 Mpp10 protein PaRep2a PF07903.11 EDN06594.1 - 0.021 14.6 0.0 0.82 9.5 0.0 2.1 2 0 0 2 2 2 0 PaRep2a protein Helicase_C PF00271.31 EDN06596.1 - 4.1e-15 56.1 0.1 1e-14 54.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1771 PF08590.10 EDN06599.1 - 1.7e-07 31.5 7.6 4.8e-07 30.1 7.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.16 EDN06599.1 - 1.7e-05 24.4 0.0 3.7e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 CUE domain Smr PF01713.21 EDN06599.1 - 0.0011 19.3 1.6 0.0016 18.7 0.0 2.1 2 1 0 2 2 2 1 Smr domain SelR PF01641.18 EDN06600.1 - 7.1e-50 168.1 0.1 8.5e-50 167.9 0.1 1.1 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 EDN06600.1 - 0.01 15.5 0.1 0.97 9.2 0.0 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 EDN06600.1 - 0.013 15.5 2.6 0.72 9.9 0.1 2.3 2 1 1 3 3 3 0 Double zinc ribbon Yippee-Mis18 PF03226.14 EDN06600.1 - 0.039 14.2 0.2 0.084 13.1 0.2 1.7 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Mss51 PF13824.6 EDN06600.1 - 0.073 13.2 5.0 0.2 11.8 0.5 3.1 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 MCM_OB PF17207.3 EDN06600.1 - 0.083 12.7 0.1 0.19 11.6 0.0 1.5 2 0 0 2 2 2 0 MCM OB domain Ribosomal_S27e PF01667.17 EDN06600.1 - 0.088 12.5 0.1 2.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 Ribosomal_L37e PF01907.19 EDN06600.1 - 0.47 10.6 5.6 3.3 7.9 1.1 2.5 2 0 0 2 2 2 0 Ribosomal protein L37e zf-ribbon_3 PF13248.6 EDN06600.1 - 4.6 6.8 6.9 3.7 7.1 0.1 3.1 4 0 0 4 4 4 0 zinc-ribbon domain HTH_33 PF13592.6 EDN06601.1 - 4.3e-06 26.3 0.0 2.3e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 EDN06601.1 - 0.00069 19.3 0.1 0.034 13.9 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EDN06601.1 - 0.015 15.3 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix HTH_7 PF02796.15 EDN06601.1 - 0.022 14.8 0.3 0.072 13.2 0.3 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase ArfGap PF01412.18 EDN06602.1 - 5.8e-40 136.0 2.0 8.7e-40 135.4 2.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GBS_Bsp-like PF08481.10 EDN06602.1 - 0.039 14.1 0.2 0.07 13.3 0.2 1.3 1 0 0 1 1 1 0 GBS Bsp-like repeat Calici_MSP PF05752.11 EDN06603.1 - 0.076 12.8 0.0 0.084 12.7 0.0 1.0 1 0 0 1 1 1 0 Calicivirus minor structural protein Synaptobrevin PF00957.21 EDN06603.1 - 0.22 11.4 5.1 2.8 7.8 1.3 2.2 1 1 1 2 2 2 0 Synaptobrevin DUF5337 PF17272.2 EDN06603.1 - 0.96 9.3 6.7 2.4 8.1 6.7 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5337) Myb_DNA-binding PF00249.31 EDN06605.1 - 0.00046 20.3 0.1 0.001 19.2 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN06605.1 - 0.021 15.0 0.0 0.04 14.2 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Kdo PF06293.14 EDN06606.1 - 0.00054 19.4 0.1 0.0013 18.2 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN06606.1 - 0.017 14.7 0.0 0.04 13.5 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EDN06606.1 - 0.031 13.9 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN06606.1 - 0.039 13.9 0.2 0.039 13.9 0.2 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDN06606.1 - 0.15 11.4 0.0 0.36 10.2 0.0 1.6 1 0 0 1 1 1 0 Protein kinase domain Zn_clus PF00172.18 EDN06607.1 - 7.2e-08 32.4 8.7 7.2e-08 32.4 8.7 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EST1_DNA_bind PF10373.9 EDN06609.1 - 0.0029 17.1 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain APH PF01636.23 EDN06610.1 - 3.6e-08 33.6 0.0 1.5e-06 28.3 0.2 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Cwf_Cwc_15 PF04889.12 EDN06612.1 - 1.4e-05 25.0 16.1 1.4e-05 25.0 16.1 2.1 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein DUF45 PF01863.17 EDN06612.1 - 0.76 9.8 5.6 2.1 8.3 5.6 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF45 TMPIT PF07851.13 EDN06612.1 - 1.4 8.1 8.2 2.1 7.5 8.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 EDN06612.1 - 7 5.9 10.2 15 4.8 10.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ank_2 PF12796.7 EDN06613.1 - 1.4e-30 105.7 0.0 1.8e-15 57.3 0.0 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN06613.1 - 5.3e-18 65.1 0.0 8.1e-09 35.9 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EDN06613.1 - 4.9e-14 52.1 0.0 6.2e-06 26.4 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EDN06613.1 - 8.1e-14 51.5 0.0 2.9e-07 30.6 0.0 3.6 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN06613.1 - 1.6e-13 49.5 0.0 0.00014 22.0 0.0 4.3 5 0 0 5 5 5 2 Ankyrin repeat PLAC8 PF04749.17 EDN06614.1 - 5.3e-09 37.0 2.9 6.6e-09 36.7 2.9 1.1 1 0 0 1 1 1 1 PLAC8 family TPR_MLP1_2 PF07926.12 EDN06615.1 - 0.0031 17.6 3.4 0.0033 17.5 3.4 1.1 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DivIC PF04977.15 EDN06615.1 - 0.0055 16.4 0.7 0.0055 16.4 0.7 2.0 1 1 1 2 2 2 1 Septum formation initiator Sec34 PF04136.15 EDN06615.1 - 0.022 14.6 2.2 2.3 8.1 0.7 2.0 1 1 1 2 2 2 0 Sec34-like family DUF641 PF04859.12 EDN06615.1 - 0.089 13.1 1.0 0.1 12.9 1.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) RICH PF05062.12 EDN06615.1 - 0.18 12.2 4.4 0.37 11.2 0.9 2.2 1 1 1 2 2 2 0 RICH domain YabA PF06156.13 EDN06615.1 - 0.24 12.0 4.0 8.6 7.1 0.2 2.0 1 1 1 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 EDN06615.1 - 0.4 10.9 0.2 0.4 10.9 0.2 2.2 2 1 0 2 2 2 0 Homeobox associated leucine zipper CENP-H PF05837.12 EDN06615.1 - 0.4 11.1 3.8 4 7.9 0.1 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ATG16 PF08614.11 EDN06616.1 - 0.00057 20.2 1.5 0.00071 19.9 1.5 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Macoilin PF09726.9 EDN06616.1 - 0.0051 15.4 0.2 0.0057 15.3 0.2 1.0 1 0 0 1 1 1 1 Macoilin family DivIC PF04977.15 EDN06616.1 - 0.034 13.9 2.3 0.87 9.4 0.4 2.5 2 1 0 2 2 2 0 Septum formation initiator NEMO PF11577.8 EDN06616.1 - 0.054 13.5 0.6 0.054 13.5 0.6 3.2 2 2 0 3 3 3 0 NF-kappa-B essential modulator NEMO CortBP2 PF09727.9 EDN06616.1 - 0.19 11.6 6.4 0.49 10.3 6.4 1.6 1 1 0 1 1 1 0 Cortactin-binding protein-2 Fer4_21 PF14697.6 EDN06616.1 - 0.21 11.7 7.9 0.34 11.1 1.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain EPF PF17181.4 EDN06616.1 - 0.87 9.6 5.9 5.8 7.0 0.1 2.7 2 1 0 2 2 2 0 Epidermal patterning factor proteins zf-CXXC PF02008.20 EDN06616.1 - 2.3 8.3 12.9 0.36 10.9 1.3 2.7 2 1 0 2 2 2 0 CXXC zinc finger domain Fer4_2 PF12797.7 EDN06616.1 - 8.7 6.7 8.7 9.7 6.5 1.4 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Pkinase PF00069.25 EDN06617.1 - 1.6e-12 47.4 0.2 4.9e-12 45.8 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06617.1 - 2.5e-07 30.2 0.0 5.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Patatin PF01734.22 EDN06618.1 - 8.1e-23 81.7 0.4 2.2e-22 80.2 0.4 1.8 1 0 0 1 1 1 1 Patatin-like phospholipase Ank_5 PF13857.6 EDN06618.1 - 1.8e-13 50.4 0.2 3.5e-07 30.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN06618.1 - 5.5e-13 47.8 0.1 9.7e-05 22.5 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EDN06618.1 - 2.4e-12 47.3 0.0 6e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EDN06618.1 - 6.5e-12 45.3 0.5 0.00026 21.3 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EDN06618.1 - 4.3e-08 33.5 0.3 0.0014 19.1 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) FAD_binding_8 PF08022.12 EDN06619.1 - 5e-11 42.7 0.0 1.2e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDN06619.1 - 1.3e-06 28.6 0.0 2.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDN06619.1 - 1.1e-05 25.6 7.2 1.1e-05 25.6 7.2 2.5 2 1 0 2 2 2 1 Ferric reductase like transmembrane component SRF-TF PF00319.18 EDN06619.1 - 1.5e-05 24.3 0.4 3.2e-05 23.3 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF4131 PF13567.6 EDN06619.1 - 4.4 6.9 10.9 0.036 13.7 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Tegument_dsDNA PF12818.7 EDN06620.1 - 0.019 14.1 0.0 0.022 13.9 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein DUF3723 PF12520.8 EDN06621.1 - 7.6e-108 361.4 0.0 8.6e-97 324.9 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3723) Lac_bphage_repr PF06543.12 EDN06623.1 - 0.063 13.3 1.0 0.12 12.3 1.0 1.4 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor RVT_1 PF00078.27 EDN06625.1 - 6.8e-38 130.4 0.0 1.3e-37 129.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN06625.1 - 5.9e-24 84.2 0.2 2e-23 82.5 0.2 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN06625.1 - 6.4e-12 45.9 0.0 1.6e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN06625.1 - 6.6e-05 22.7 0.1 0.00019 21.2 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase-like Exo_endo_phos PF03372.23 EDN06625.1 - 0.0003 20.4 0.1 0.00095 18.7 0.1 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PuR_N PF09182.10 EDN06625.1 - 0.00072 19.4 0.1 0.0045 16.9 0.1 2.3 2 0 0 2 2 2 1 Bacterial purine repressor, N-terminal zf-CCHC PF00098.23 EDN06625.1 - 0.012 15.7 4.6 0.033 14.3 4.6 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-C3HC4 PF00097.25 EDN06626.1 - 0.0001 22.1 3.7 0.00026 20.8 3.8 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN06626.1 - 0.00028 20.7 9.2 0.00041 20.1 9.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HAUS-augmin3 PF14932.6 EDN06626.1 - 0.00052 19.7 1.4 0.00071 19.2 1.4 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Lebercilin PF15619.6 EDN06626.1 - 0.0017 18.0 4.7 0.0017 18.0 4.7 1.7 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.8 EDN06626.1 - 0.0032 17.6 2.4 0.0032 17.6 2.4 1.5 2 0 0 2 2 1 1 Afadin- and alpha -actinin-Binding Spc29 PF17082.5 EDN06626.1 - 0.0044 16.9 2.0 0.0054 16.6 2.0 1.0 1 0 0 1 1 1 1 Spindle Pole Component 29 ATG16 PF08614.11 EDN06626.1 - 0.0088 16.3 1.9 0.01 16.1 1.9 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.22 EDN06626.1 - 0.011 15.9 0.4 0.019 15.2 0.4 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain zf-C3HC4_2 PF13923.6 EDN06626.1 - 0.013 15.3 7.3 0.03 14.2 7.4 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UPF0242 PF06785.11 EDN06626.1 - 0.014 15.5 3.8 0.022 14.9 3.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Interferon PF00143.19 EDN06626.1 - 0.015 15.5 0.1 0.02 15.1 0.1 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain DUF4407 PF14362.6 EDN06626.1 - 0.015 14.6 0.4 0.02 14.2 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 EDN06626.1 - 0.016 15.6 3.6 0.024 15.1 3.6 1.2 1 0 0 1 1 1 0 Fez1 DUF848 PF05852.11 EDN06626.1 - 0.017 15.3 0.2 0.022 14.8 0.2 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DegS PF05384.11 EDN06626.1 - 0.024 14.1 4.9 0.037 13.5 4.9 1.2 1 0 0 1 1 1 0 Sensor protein DegS DivIC PF04977.15 EDN06626.1 - 0.025 14.3 3.0 0.048 13.4 3.0 1.5 1 0 0 1 1 1 0 Septum formation initiator Tox-REase-9 PF15650.6 EDN06626.1 - 0.025 14.8 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 DUF4200 PF13863.6 EDN06626.1 - 0.026 14.9 5.0 0.041 14.3 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) HAUS5 PF14817.6 EDN06626.1 - 0.031 13.1 4.1 0.039 12.7 4.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 Fib_alpha PF08702.10 EDN06626.1 - 0.048 13.8 1.6 0.069 13.3 1.6 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-RING_5 PF14634.6 EDN06626.1 - 0.066 13.2 7.4 0.12 12.4 7.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain APC_N_CC PF16689.5 EDN06626.1 - 0.066 13.3 1.4 0.11 12.5 1.4 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Flg_hook PF02120.16 EDN06626.1 - 0.068 13.1 0.6 0.091 12.7 0.6 1.2 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Macoilin PF09726.9 EDN06626.1 - 0.074 11.6 4.4 0.092 11.3 4.4 1.1 1 0 0 1 1 1 0 Macoilin family HALZ PF02183.18 EDN06626.1 - 0.12 12.6 1.7 1.1 9.5 0.2 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF1664 PF07889.12 EDN06626.1 - 0.14 12.2 2.4 0.2 11.7 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2730 PF10805.8 EDN06626.1 - 0.15 12.2 0.6 0.23 11.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) CALCOCO1 PF07888.11 EDN06626.1 - 0.16 10.8 6.9 0.22 10.4 6.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4164 PF13747.6 EDN06626.1 - 0.16 12.3 5.8 0.31 11.4 5.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Trimer_CC PF08954.11 EDN06626.1 - 0.18 11.4 6.3 0.33 10.5 6.3 1.4 1 0 0 1 1 1 0 Trimerisation motif TMF_TATA_bd PF12325.8 EDN06626.1 - 0.18 12.0 6.0 0.37 11.0 6.0 1.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding OmpH PF03938.14 EDN06626.1 - 0.19 12.1 3.1 0.29 11.5 3.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SlyX PF04102.12 EDN06626.1 - 0.28 11.8 3.1 0.29 11.8 1.5 1.8 2 0 0 2 2 1 0 SlyX Troponin PF00992.20 EDN06626.1 - 0.55 10.5 8.9 0.071 13.4 5.2 1.3 2 0 0 2 2 1 0 Troponin DUF3435 PF11917.8 EDN06627.1 - 3.5e-62 210.7 7.4 5.1e-62 210.1 7.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DUF3435 PF11917.8 EDN06630.1 - 3.6e-160 533.5 0.1 5e-160 533.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) PRIMA1 PF16101.5 EDN06630.1 - 0.94 9.5 3.3 1.7 8.7 3.3 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EDN06630.1 - 3.5 7.0 6.0 0.73 9.3 1.7 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DUF5394 PF17372.2 EDN06630.1 - 9.2 5.8 8.9 8.6 5.8 5.1 2.6 2 1 2 4 4 4 0 Family of unknown function (DUF5394) RVT_2 PF07727.14 EDN06631.1 - 1.4e-56 191.9 0.0 2.3e-56 191.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06631.1 - 1.8e-11 44.3 0.0 1.1e-10 41.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN06631.1 - 1.4e-07 31.3 0.0 3.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF4219 PF13961.6 EDN06631.1 - 0.00011 21.8 0.1 0.00033 20.3 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) rve_3 PF13683.6 EDN06631.1 - 0.049 13.4 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain Zn_ribbon_17 PF17120.5 EDN06632.1 - 3.4e-08 33.0 12.7 3.4e-08 33.0 12.7 2.4 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 EDN06632.1 - 4.9e-06 27.2 21.4 0.0018 19.1 0.0 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat RWD PF05773.22 EDN06632.1 - 0.018 15.3 0.0 0.044 14.1 0.0 1.6 1 0 0 1 1 1 0 RWD domain zf-RING_2 PF13639.6 EDN06632.1 - 0.12 12.8 16.1 0.024 15.0 8.7 2.5 2 0 0 2 2 2 0 Ring finger domain zf-RING_10 PF16685.5 EDN06632.1 - 0.12 12.5 1.8 0.29 11.3 1.8 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_14 PF17978.1 EDN06632.1 - 1.1 9.7 6.5 2.2 8.8 6.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SCAN PF02023.17 EDN06633.1 - 0.037 13.8 1.6 0.062 13.1 1.6 1.3 1 0 0 1 1 1 0 SCAN domain Rep-A_N PF04057.12 EDN06633.1 - 0.15 12.1 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Swm2 PF17083.5 EDN06633.1 - 0.15 12.1 0.2 0.22 11.5 0.2 1.2 1 0 0 1 1 1 0 Nucleolar protein Swm2 HTH_Tnp_Tc3_2 PF01498.18 EDN06634.1 - 1.3e-16 60.5 0.0 3.1e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Transposase DDE_3 PF13358.6 EDN06634.1 - 4.5e-05 23.2 1.1 9.6e-05 22.2 0.4 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 EDN06634.1 - 0.084 12.5 0.0 0.084 12.5 0.0 2.9 4 0 0 4 4 4 0 Winged helix-turn helix Rrn6 PF10214.9 EDN06634.1 - 0.37 9.2 3.7 0.51 8.8 3.7 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor HTH_29 PF13551.6 EDN06635.1 - 0.14 12.2 0.1 0.46 10.6 0.1 1.8 1 1 0 1 1 1 0 Winged helix-turn helix UQ_con PF00179.26 EDN06636.1 - 3.1e-46 156.5 0.0 3.5e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN06636.1 - 9.3e-05 22.1 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDN06636.1 - 0.0052 16.6 0.0 0.0076 16.1 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EDN06636.1 - 0.037 14.3 0.1 0.055 13.8 0.0 1.3 1 1 0 1 1 1 0 RWD domain Ribosomal_L24e PF01246.20 EDN06637.1 - 5.9e-28 96.9 0.1 5.9e-28 96.9 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e Ribosomal_S30 PF04758.14 EDN06638.1 - 4.3e-30 103.7 8.8 4.7e-30 103.6 8.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 RPA43_OB PF17875.1 EDN06640.1 - 0.06 14.0 0.2 0.067 13.8 0.2 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Acetyltransf_1 PF00583.25 EDN06641.1 - 1.3e-07 31.9 0.1 1.7e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN06641.1 - 2e-05 24.6 0.0 2.9e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN06641.1 - 4.6e-05 23.8 0.2 6.7e-05 23.2 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain 4HBT PF03061.22 EDN06642.1 - 1.6e-10 41.1 0.0 3.4e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily UCH PF00443.29 EDN06643.1 - 2.1e-51 174.9 0.0 2.8e-51 174.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN06643.1 - 1.1e-10 41.7 5.4 4.6e-06 26.5 1.9 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EDN06643.1 - 7.1e-10 38.5 0.0 1.6e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF4795 PF16043.5 EDN06643.1 - 0.045 13.3 3.3 0.12 12.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) ARPC4 PF05856.12 EDN06644.1 - 6.4e-79 263.4 3.8 7.2e-79 263.2 3.8 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) TYW3 PF02676.14 EDN06646.1 - 2.6e-71 239.4 0.0 3.2e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 LSDAT_euk PF18139.1 EDN06646.1 - 0.011 15.2 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 SLOG in TRPM DUF2461 PF09365.10 EDN06647.1 - 3.2e-35 122.0 1.9 6.2e-35 121.1 1.9 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) HNH_2 PF13391.6 EDN06651.1 - 1.2e-05 25.3 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Pkinase PF00069.25 EDN06652.1 - 4.5e-66 222.9 0.0 2.4e-65 220.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 EDN06652.1 - 3.7e-36 123.4 0.2 7.5e-36 122.4 0.2 1.5 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 EDN06652.1 - 1.3e-33 116.4 0.0 1.7e-31 109.5 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN06652.1 - 0.00017 20.6 0.0 0.00046 19.3 0.0 1.7 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDN06652.1 - 0.0027 17.1 0.0 0.0069 15.8 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDN06652.1 - 0.0044 16.4 0.0 0.0079 15.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDN06652.1 - 0.0096 15.9 0.1 0.053 13.4 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN06652.1 - 0.036 13.6 0.1 0.075 12.6 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase PhoD PF09423.10 EDN06653.1 - 7.7e-100 334.3 0.2 1.1e-99 333.9 0.2 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EDN06653.1 - 8.4e-29 100.0 0.0 2.6e-19 69.5 0.0 2.8 1 1 1 2 2 2 2 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EDN06653.1 - 5e-05 23.8 0.3 0.00022 21.7 0.1 2.2 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain p450 PF00067.22 EDN06654.1 - 1.3e-28 99.9 0.0 2e-26 92.8 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 NLPC_P60 PF00877.19 EDN06655.1 - 9.6e-12 44.9 0.0 1.6e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 NlpC/P60 family TonB_N PF16031.5 EDN06655.1 - 0.12 12.9 9.9 0.19 12.3 9.9 1.3 1 0 0 1 1 1 0 TonB polyproline region Fasciclin PF02469.22 EDN06656.1 - 2e-39 134.7 0.0 5.6e-21 75.1 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain DAO PF01266.24 EDN06657.1 - 4.1e-25 89.1 0.1 4.9e-25 88.9 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN06657.1 - 0.094 11.9 0.0 0.33 10.2 0.0 1.7 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Redoxin PF08534.10 EDN06658.1 - 1.1e-40 138.7 0.0 1.2e-40 138.6 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDN06658.1 - 7.9e-10 38.7 0.0 1.1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family POP1 PF06978.11 EDN06659.1 - 1.1e-74 250.9 10.3 1.1e-74 250.9 10.3 2.2 3 0 0 3 3 3 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EDN06659.1 - 5.3e-30 103.6 1.6 6.1e-30 103.4 0.1 1.9 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T PF01571.21 EDN06659.1 - 0.021 14.2 0.0 0.15 11.4 0.0 2.2 3 0 0 3 3 3 0 Aminomethyltransferase folate-binding domain DUF1690 PF07956.11 EDN06660.1 - 5.5e-31 107.8 7.9 5e-20 72.4 0.1 2.1 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) Hexokinase_2 PF03727.16 EDN06661.1 - 2.2e-76 256.5 0.0 2.9e-76 256.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDN06661.1 - 8.2e-73 244.5 0.0 1.2e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Gly-zipper_Omp PF13488.6 EDN06661.1 - 0.22 11.6 6.3 2.1 8.4 1.3 2.5 2 0 0 2 2 2 0 Glycine zipper zf-C2HC5 PF06221.13 EDN06662.1 - 6.6e-21 74.1 8.5 1.2e-20 73.3 8.5 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DUF604 PF04646.12 EDN06663.1 - 1.2e-08 34.7 0.0 2.1e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.16 EDN06663.1 - 2.4e-05 23.9 0.0 5.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Fringe-like Serglycin PF04360.12 EDN06663.1 - 0.055 13.4 0.6 0.16 11.9 0.6 1.8 1 0 0 1 1 1 0 Serglycin GDI PF00996.18 EDN06664.1 - 4.6e-27 94.6 0.0 1.5e-25 89.6 0.0 2.0 1 1 0 1 1 1 1 GDP dissociation inhibitor Pro_isomerase PF00160.21 EDN06665.1 - 3.2e-47 160.7 0.0 3.7e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.25 EDN06666.1 - 1.7e-17 63.7 0.1 1.7e-15 57.1 0.1 2.9 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06666.1 - 1.1e-07 31.4 0.0 2.4e-07 30.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EDN06666.1 - 0.00068 19.9 0.7 0.0017 18.7 0.1 2.1 2 0 0 2 2 2 1 FHA domain Kdo PF06293.14 EDN06666.1 - 0.035 13.4 0.0 0.095 12.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN06667.1 - 1e-141 472.5 0.0 1.2e-141 472.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN06667.1 - 3.2e-07 30.0 0.0 5.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06667.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN06667.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family HTH_Tnp_Tc5 PF03221.16 EDN06668.1 - 3.4e-06 27.0 0.4 9.9e-06 25.5 0.1 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 EDN06668.1 - 0.00046 19.9 0.2 0.0022 17.7 0.2 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 EDN06668.1 - 0.00087 19.0 0.1 0.002 17.8 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Peptidase_A22B PF04258.13 EDN06669.1 - 3.6e-39 135.0 1.5 6.3e-39 134.2 0.9 1.6 2 0 0 2 2 2 1 Signal peptide peptidase SPP PF06550.11 EDN06669.1 - 5.2e-07 29.4 4.0 1.1e-06 28.4 4.0 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease RNase_PH PF01138.21 EDN06670.1 - 1.2e-17 64.6 2.9 2.7e-16 60.3 2.9 2.3 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Ferric_reduct PF01794.19 EDN06671.1 - 1.3e-17 64.1 7.3 1.3e-17 64.1 7.3 2.6 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EDN06671.1 - 1.6e-17 64.0 0.0 7.6e-17 61.9 0.0 1.9 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EDN06671.1 - 0.012 16.3 0.0 8.9 7.0 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DGCR6 PF07324.11 EDN06673.1 - 0.0014 18.3 0.1 0.0021 17.7 0.1 1.2 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein Tetraspanin PF00335.20 EDN06674.1 - 0.0062 16.3 3.0 0.055 13.2 0.3 2.0 1 1 1 2 2 2 2 Tetraspanin family Fungal_trans_2 PF11951.8 EDN06675.1 - 1.2e-05 24.4 2.3 2.3e-05 23.4 1.0 2.1 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN06675.1 - 0.0014 18.7 2.4 0.0023 18.0 2.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 EDN06676.1 - 6.9e-16 58.5 0.0 2.4e-14 53.5 0.0 2.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN06676.1 - 1.2e-13 51.4 0.0 2.4e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EDN06676.1 - 7e-05 23.1 0.1 0.00069 19.9 0.0 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EDN06676.1 - 0.00039 20.0 0.1 0.001 18.6 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EDN06676.1 - 0.002 18.2 0.0 0.0056 16.7 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 EDN06676.1 - 0.011 14.8 0.0 0.022 13.8 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ApbA PF02558.16 EDN06676.1 - 0.068 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Gp_dh_N PF00044.24 EDN06676.1 - 0.092 13.1 0.0 0.27 11.6 0.0 1.8 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain TrkA_N PF02254.18 EDN06676.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain DapB_N PF01113.20 EDN06676.1 - 0.19 11.9 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus SRF-TF PF00319.18 EDN06677.1 - 4.1e-21 74.2 0.1 5.9e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_60s PF00428.19 EDN06677.1 - 0.29 11.7 15.1 0.11 13.1 12.1 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3246 PF11596.8 EDN06677.1 - 1.2 8.5 2.9 0.68 9.3 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3246) Mg_trans_NIPA PF05653.14 EDN06678.1 - 1.3e-10 40.9 7.3 1.1e-06 27.9 1.5 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA PUNUT PF16913.5 EDN06678.1 - 1.2e-05 24.7 1.9 1.2e-05 24.7 1.9 2.1 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 EDN06678.1 - 5e-05 23.5 1.2 5e-05 23.5 1.2 2.7 3 0 0 3 3 3 1 EamA-like transporter family IRK_N PF08466.10 EDN06678.1 - 0.029 14.5 0.1 0.1 12.8 0.1 2.0 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal vATP-synt_E PF01991.18 EDN06679.1 - 1.4e-57 194.3 6.9 1.8e-57 194.0 6.9 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF2987 PF11205.8 EDN06679.1 - 0.05 13.5 2.4 0.13 12.2 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2987) TTc_toxin_rep PF18807.1 EDN06679.1 - 0.092 12.6 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Tripartite Tc toxins repeat DUF2564 PF10819.8 EDN06679.1 - 0.62 10.5 6.8 33 4.9 0.2 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2564) Metallophos PF00149.28 EDN06680.1 - 1.8e-09 38.4 0.1 4.8e-09 37.0 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN06680.1 - 1.4e-06 28.6 0.2 5e-05 23.5 0.0 2.8 1 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain PhoLip_ATPase_C PF16212.5 EDN06682.1 - 1.8e-79 267.1 21.5 1.8e-79 267.1 21.5 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDN06682.1 - 1.3e-19 69.6 0.3 1.3e-19 69.6 0.3 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EDN06682.1 - 4.9e-12 45.8 0.0 3.2e-11 43.1 0.0 2.4 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDN06682.1 - 1.5e-11 45.0 0.1 2.2e-06 28.1 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDN06682.1 - 0.00024 20.7 0.0 0.0015 18.1 0.0 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDN06682.1 - 0.0059 16.4 0.3 0.015 15.1 0.3 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 EDN06683.1 - 0.003 17.0 0.0 0.0039 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SEN1_N PF12726.7 EDN06684.1 - 7.1e-208 692.5 5.3 9.9e-208 692.0 5.3 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EDN06684.1 - 1.5e-70 238.0 0.8 1.5e-70 238.0 0.8 2.5 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EDN06684.1 - 1.2e-59 201.3 0.0 2.4e-59 200.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN06684.1 - 3.3e-09 36.7 0.1 2.5e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 EDN06684.1 - 6.1e-08 32.5 0.3 4e-06 26.6 0.0 2.9 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EDN06684.1 - 3e-07 30.4 0.1 0.04 13.6 0.0 3.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EDN06684.1 - 1.2e-05 25.7 0.0 7.2e-05 23.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain zf-CCHC PF00098.23 EDN06684.1 - 0.056 13.5 19.3 0.12 12.5 1.0 3.5 3 0 0 3 3 3 0 Zinc knuckle T2SSE PF00437.20 EDN06684.1 - 0.076 12.1 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DEAD PF00270.29 EDN06684.1 - 0.088 12.6 0.1 0.34 10.7 0.0 2.0 2 0 0 2 2 2 0 DEAD/DEAH box helicase zf-CCHC_5 PF14787.6 EDN06684.1 - 0.14 11.9 14.8 0.18 11.6 2.4 2.9 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger ResIII PF04851.15 EDN06684.1 - 0.27 11.2 3.6 1.1 9.2 0.0 3.1 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit zf-CCHC_3 PF13917.6 EDN06684.1 - 3.3 7.7 12.9 2.3 8.2 1.4 3.2 1 1 2 3 3 3 0 Zinc knuckle Amidohydro_1 PF01979.20 EDN06686.1 - 1.8e-05 24.3 0.0 4.8e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 EDN06686.1 - 7.7e-05 22.6 0.0 0.00012 22.0 0.0 1.3 1 1 0 1 1 1 1 Amidohydrolase Lipase_GDSL PF00657.22 EDN06687.1 - 6.9e-08 32.7 0.0 9e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EDN06687.1 - 7.8e-06 26.4 1.5 3.1e-05 24.5 1.5 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family YL1_C PF08265.11 EDN06687.1 - 0.092 12.5 0.5 0.26 11.1 0.1 2.0 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain LIM PF00412.22 EDN06688.1 - 6e-20 71.2 43.7 3.3e-12 46.4 3.8 5.0 4 1 0 4 4 4 3 LIM domain TLP1_add_C PF18313.1 EDN06688.1 - 0.11 12.5 0.6 0.2 11.6 0.6 1.4 1 0 0 1 1 1 0 Thiolase-like protein type 1 additional C-terminal domain CorA PF01544.18 EDN06689.1 - 8e-08 31.9 0.0 1.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ApoL PF05461.11 EDN06689.1 - 0.11 11.8 2.2 0.38 10.0 0.2 2.1 2 0 0 2 2 2 0 Apolipoprotein L RHH_3 PF12651.7 EDN06689.1 - 0.24 11.4 3.0 0.54 10.3 0.3 2.6 2 0 0 2 2 2 0 Ribbon-helix-helix domain SUIM_assoc PF16619.5 EDN06689.1 - 1.4 9.1 4.6 3.7 7.7 4.6 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CDK5_activator PF03261.15 EDN06690.1 - 0.06 12.9 0.0 0.16 11.5 0.0 1.6 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein WH1 PF00568.23 EDN06692.1 - 2.3e-28 98.4 0.0 3.6e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EDN06692.1 - 3.3e-05 23.6 2.7 3.7e-05 23.4 0.4 2.2 2 0 0 2 2 2 1 WH2 motif DDE_Tnp_4 PF13359.6 EDN06696.1 - 5.7e-08 32.6 0.2 1.1e-07 31.6 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EDN06696.1 - 0.058 13.0 0.1 0.3 10.7 0.1 2.1 1 1 1 2 2 2 0 Transposase DDE domain Clusterin PF01093.17 EDN06696.1 - 0.14 11.2 2.6 0.22 10.5 0.4 2.1 2 1 0 2 2 2 0 Clusterin DDE_Tnp_1_7 PF13843.6 EDN06697.1 - 4.5e-29 101.9 0.0 1.4e-11 44.4 0.0 3.2 2 1 1 3 3 3 3 Transposase IS4 eIF-1a PF01176.19 EDN06699.1 - 4.7e-22 77.6 0.0 6.6e-22 77.1 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 ERCC4 PF02732.15 EDN06700.1 - 2.2e-19 70.2 0.4 2.2e-18 67.0 0.0 2.5 3 0 0 3 3 3 1 ERCC4 domain DUF4780 PF16012.5 EDN06700.1 - 0.0024 17.4 0.0 5.9 6.3 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4780) HHH_5 PF14520.6 EDN06700.1 - 0.01 16.4 0.0 0.024 15.2 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH PF00633.23 EDN06700.1 - 0.13 12.1 0.3 0.71 9.9 0.0 2.4 3 0 0 3 3 3 0 Helix-hairpin-helix motif HHH_2 PF12826.7 EDN06700.1 - 0.18 12.0 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif AA_kinase PF00696.28 EDN06700.1 - 0.19 11.3 0.0 0.38 10.3 0.0 1.4 1 0 0 1 1 1 0 Amino acid kinase family fn3_2 PF16893.5 EDN06701.1 - 1.2e-37 127.9 0.1 2e-37 127.2 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EDN06701.1 - 1.1e-24 86.0 0.4 2.4e-24 85.0 0.4 1.6 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EDN06701.1 - 1.8e-14 53.4 0.0 3.4e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EDN06701.1 - 5.9e-09 36.2 0.0 9.7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 EDN06701.1 - 9.5e-05 22.6 0.0 0.00025 21.2 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 EDN06701.1 - 0.0003 21.1 0.0 0.00057 20.2 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 EDN06701.1 - 0.0086 16.4 0.0 0.03 14.7 0.0 1.8 1 1 0 1 1 1 1 Fibronectin type III domain MFS_1 PF07690.16 EDN06702.1 - 4.9e-51 173.7 36.8 4.9e-51 173.7 36.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN06702.1 - 8.4e-12 44.7 9.5 8.4e-12 44.7 9.5 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EDN06702.1 - 0.00012 20.5 6.1 0.00012 20.5 6.1 3.4 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family BT1 PF03092.16 EDN06702.1 - 0.009 14.3 3.1 0.098 10.9 1.6 2.5 1 1 1 2 2 2 1 BT1 family DUF2269 PF10027.9 EDN06702.1 - 2 8.5 10.6 4.3 7.4 3.3 2.7 2 1 0 2 2 2 0 Predicted integral membrane protein (DUF2269) Evr1_Alr PF04777.13 EDN06703.1 - 6.9e-27 93.9 0.4 1.1e-26 93.2 0.4 1.3 1 0 0 1 1 1 1 Erv1 / Alr family Methyltransf_23 PF13489.6 EDN06704.1 - 9.4e-19 67.8 0.0 1.4e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN06704.1 - 3.3e-09 37.3 0.0 7.9e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN06704.1 - 2.2e-07 31.4 0.0 4.4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN06704.1 - 6.5e-07 30.0 0.0 5.4e-06 27.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN06704.1 - 2.3e-06 27.5 0.0 5.9e-05 22.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EDN06704.1 - 0.14 11.6 0.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase MFS_1 PF07690.16 EDN06705.1 - 2.9e-15 56.1 17.1 6e-12 45.1 8.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 EDN06705.1 - 0.013 14.2 0.0 0.046 12.4 0.0 1.8 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like zf-LYAR PF08790.11 EDN06706.1 - 0.11 12.4 0.2 0.26 11.2 0.2 1.7 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger R3H PF01424.22 EDN06707.1 - 1.5e-11 44.1 0.0 2.8e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 EDN06707.1 - 2e-06 27.7 48.4 3.4e-05 23.8 6.6 12.0 10 4 2 12 12 12 5 NF-X1 type zinc finger PAM2 PF07145.15 EDN06707.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region G_glu_transpept PF01019.21 EDN06708.1 - 2.2e-162 541.4 0.2 2.5e-162 541.2 0.2 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase HhH-GPD PF00730.25 EDN06709.1 - 1.6e-07 31.8 0.0 1.8e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein APH PF01636.23 EDN06713.1 - 0.00027 21.0 0.2 0.0092 15.9 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family zf-AN1 PF01428.16 EDN06713.1 - 4.2 7.6 17.8 0.19 11.9 12.3 1.7 2 0 0 2 2 2 0 AN1-like Zinc finger Fungal_trans PF04082.18 EDN06714.1 - 2e-20 72.9 0.5 3.3e-20 72.3 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN06714.1 - 3e-08 33.6 10.6 5.9e-08 32.7 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_A_type_inc PF04508.12 EDN06714.1 - 0.043 13.7 4.4 0.095 12.6 4.4 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Git3 PF11710.8 EDN06716.1 - 1.1e-28 100.4 15.8 2.1e-28 99.5 15.8 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EDN06716.1 - 2.4e-11 43.6 0.2 3.7e-10 39.7 0.0 2.6 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EDN06716.1 - 4.4e-05 22.8 13.6 6.2e-05 22.3 13.6 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Gate PF07670.14 EDN06716.1 - 0.048 13.9 0.1 0.091 13.0 0.0 1.6 1 1 0 1 1 1 0 Nucleoside recognition RTA1 PF04479.13 EDN06717.1 - 2.8e-62 210.0 8.1 4.6e-62 209.3 8.1 1.3 1 0 0 1 1 1 1 RTA1 like protein PDR_CDR PF06422.12 EDN06719.1 - 0.012 15.5 0.1 0.013 15.4 0.1 1.1 1 0 0 1 1 1 0 CDR ABC transporter NrsF PF06532.11 EDN06719.1 - 0.019 14.7 0.1 0.022 14.5 0.1 1.0 1 0 0 1 1 1 0 Negative regulator of sigma F DUF2076 PF09849.9 EDN06721.1 - 0.12 12.4 8.3 0.13 12.2 8.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Peroxin-13_N PF04088.13 EDN06721.1 - 0.31 11.3 0.9 0.33 11.2 0.9 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Presenilin PF01080.17 EDN06721.1 - 0.35 9.6 6.0 0.4 9.4 6.0 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 EDN06721.1 - 0.5 9.1 4.7 0.63 8.8 4.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4834 PF16118.5 EDN06721.1 - 0.79 10.7 8.9 1.2 10.1 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SARAF PF06682.12 EDN06721.1 - 0.92 9.1 8.3 1.2 8.7 8.3 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Gti1_Pac2 PF09729.9 EDN06721.1 - 1 9.4 11.3 1.4 8.9 11.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Folate_carrier PF01770.18 EDN06721.1 - 1.4 7.6 5.8 1.6 7.4 5.8 1.1 1 0 0 1 1 1 0 Reduced folate carrier FemAB PF02388.16 EDN06721.1 - 3.4 6.5 10.4 4.5 6.0 10.4 1.1 1 0 0 1 1 1 0 FemAB family NPR3 PF03666.13 EDN06721.1 - 4.5 6.0 11.7 5.7 5.6 11.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CSG2 PF16965.5 EDN06721.1 - 5 6.0 6.3 6.1 5.7 6.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 EDN06721.1 - 5.6 6.7 4.7 7.2 6.3 4.7 1.1 1 0 0 1 1 1 0 Connexin Zip PF02535.22 EDN06721.1 - 8.6 5.5 7.2 11 5.1 7.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter YjbH PF06082.11 EDN06724.1 - 0.19 10.5 0.1 0.26 10.1 0.1 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH NAD_binding_11 PF14833.6 EDN06726.1 - 5.2e-45 152.6 5.8 4.1e-29 101.3 0.1 2.3 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EDN06726.1 - 4.6e-32 111.4 1.7 9.3e-32 110.4 1.7 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EDN06726.1 - 0.0026 17.6 0.1 0.0054 16.6 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EDN06726.1 - 0.058 14.0 0.3 0.17 12.5 0.3 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh PF00984.19 EDN06726.1 - 2.1 8.6 4.4 3.7 7.8 0.0 2.8 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain ADH_zinc_N PF00107.26 EDN06727.1 - 1.4e-08 34.8 0.0 2e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDN06727.1 - 0.0071 17.4 0.0 0.011 16.8 0.0 1.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN06728.1 - 0.00019 21.3 0.0 0.00022 21.1 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FAD_binding_3 PF01494.19 EDN06729.1 - 1.9e-72 244.5 0.0 2.3e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 EDN06729.1 - 0.067 12.2 0.0 0.37 9.8 0.0 1.9 1 1 0 1 1 1 0 Squalene epoxidase Cass2 PF14526.6 EDN06729.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Integron-associated effector binding protein Pkinase PF00069.25 EDN06730.1 - 5.2e-28 98.1 0.0 7.9e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06730.1 - 1.2e-09 37.9 0.0 1.7e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN06730.1 - 1.7e-05 24.3 0.0 2.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like NMT1 PF09084.11 EDN06731.1 - 1.4e-63 214.7 0.0 1.8e-63 214.4 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like PBP_like PF12727.7 EDN06731.1 - 0.061 12.4 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 PBP superfamily domain Abhydrolase_6 PF12697.7 EDN06732.1 - 5.6e-18 66.4 0.1 1.1e-17 65.4 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family F_bP_aldolase PF01116.20 EDN06732.1 - 3.4e-12 46.4 0.1 5.8e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Abhydrolase_1 PF00561.20 EDN06732.1 - 4.3e-12 46.2 0.1 1.6e-10 41.1 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN06732.1 - 0.00022 20.5 0.0 0.00046 19.5 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Fer2_3 PF13085.6 EDN06733.1 - 7.4e-32 109.6 0.0 1.2e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EDN06733.1 - 9.7e-09 35.7 5.6 9.7e-09 35.7 5.6 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDN06733.1 - 1.1e-07 31.9 2.6 1.1e-07 31.9 2.6 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDN06733.1 - 1.9e-07 31.4 6.6 1.9e-07 31.4 6.6 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDN06733.1 - 0.0018 18.8 4.3 0.0018 18.8 4.3 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EDN06733.1 - 0.0069 16.3 0.4 0.0069 16.3 0.4 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 EDN06733.1 - 4.6 7.5 14.0 6 7.1 9.7 2.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain DPBB_1 PF03330.18 EDN06734.1 - 1.7e-07 31.4 0.0 3.4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EDN06734.1 - 0.0033 17.2 0.1 0.0057 16.5 0.1 1.3 1 0 0 1 1 1 1 Barwin family ThiF PF00899.21 EDN06735.1 - 1.1e-56 191.9 0.0 1.7e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EDN06735.1 - 6e-07 30.0 0.0 3.8e-06 27.4 0.0 2.3 2 1 0 2 2 2 1 Rhodanese-like domain ApbA PF02558.16 EDN06735.1 - 0.028 14.1 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EDN06735.1 - 0.034 13.4 0.7 0.051 12.8 0.7 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 EDN06735.1 - 0.092 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EDN06735.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DAO PF01266.24 EDN06735.1 - 0.2 11.2 2.0 0.34 10.5 2.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase SLX9 PF15341.6 EDN06736.1 - 3.8e-36 124.4 2.8 5.2e-36 123.9 2.8 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 NAD_Gly3P_dh_N PF01210.23 EDN06737.1 - 1.3e-45 155.2 0.0 2.7e-45 154.1 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EDN06737.1 - 6.6e-44 149.6 0.2 1.2e-43 148.8 0.2 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus hDGE_amylase PF14701.6 EDN06738.1 - 1.4e-173 578.1 0.0 1.9e-173 577.6 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EDN06738.1 - 6.1e-119 397.4 0.0 8.5e-119 396.9 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EDN06738.1 - 1.1e-83 280.8 0.0 1.9e-83 280.0 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EDN06738.1 - 3.7e-26 91.1 0.0 8.1e-26 90.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Pkinase PF00069.25 EDN06738.1 - 2.5e-12 46.7 0.0 4.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06738.1 - 8.4e-09 35.1 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EDN06738.1 - 0.016 14.9 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EDN06738.1 - 0.017 13.9 0.1 0.029 13.2 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EDN06738.1 - 0.088 12.7 0.1 0.23 11.3 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family RSN1_7TM PF02714.15 EDN06739.1 - 1.1e-64 218.4 17.2 2.1e-64 217.5 17.2 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EDN06739.1 - 3.1e-40 138.3 0.0 6.4e-40 137.2 0.0 1.5 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EDN06739.1 - 7.3e-36 123.3 1.3 7.3e-36 123.3 1.3 2.2 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport Anoctamin PF04547.12 EDN06739.1 - 0.00053 19.0 1.2 0.00053 19.0 1.2 2.2 2 0 0 2 2 2 1 Calcium-activated chloride channel Phage_holin_3_3 PF16083.5 EDN06739.1 - 0.093 12.9 0.0 0.32 11.1 0.0 1.9 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III DAHP_synth_1 PF00793.20 EDN06740.1 - 2.4e-104 348.0 0.0 2.9e-104 347.8 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family AIG2_2 PF13772.6 EDN06742.1 - 4.4e-05 23.8 0.1 0.00013 22.3 0.1 1.8 2 0 0 2 2 2 1 AIG2-like family Cytochrom_C1 PF02167.15 EDN06743.1 - 4.3e-93 311.0 0.0 5.3e-93 310.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrom_C PF00034.21 EDN06743.1 - 0.028 15.5 0.0 0.12 13.6 0.0 2.1 2 0 0 2 2 2 0 Cytochrome c Cytochrome_CBB3 PF13442.6 EDN06743.1 - 0.054 13.8 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III AAA PF00004.29 EDN06744.1 - 4.8e-19 69.1 0.2 7.2e-19 68.5 0.2 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sec10 PF07393.11 EDN06745.1 - 2.8e-152 508.7 0.5 3.5e-152 508.4 0.5 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 EDN06745.1 - 3.4e-07 30.0 0.2 8.7e-07 28.7 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN06745.1 - 3.7e-05 23.5 0.1 9e-05 22.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDN06745.1 - 0.013 15.4 0.1 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 F-box RNase_H PF00075.24 EDN06746.1 - 4.8e-12 46.3 0.0 9.6e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.27 EDN06746.1 - 3.7e-10 39.7 0.0 6.6e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Nexin_C PF08628.12 EDN06747.1 - 0.0037 17.8 0.6 0.0044 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal WD40 PF00400.32 EDN06748.1 - 4.7e-60 198.1 29.5 5.2e-11 42.9 0.2 9.1 8 1 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN06748.1 - 8.8e-20 70.8 4.4 0.00038 20.7 0.1 6.1 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN06748.1 - 6.9e-08 32.6 0.0 0.024 14.5 0.0 3.4 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDN06748.1 - 5.1e-06 25.4 7.0 0.51 8.9 0.1 5.6 4 2 2 6 6 6 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDN06748.1 - 1.7e-05 23.9 0.1 0.033 13.2 0.0 4.5 3 2 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 EDN06748.1 - 5.6e-05 23.6 0.0 0.00013 22.4 0.0 1.7 1 0 0 1 1 1 1 NLE (NUC135) domain WD40_like PF17005.5 EDN06748.1 - 0.0089 15.4 0.0 7.8 5.7 0.0 3.4 4 0 0 4 4 4 2 WD40-like domain MutS_V PF00488.21 EDN06749.1 - 1.6e-64 217.4 0.4 2.6e-64 216.7 0.4 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDN06749.1 - 5.3e-25 88.8 1.9 5.3e-25 88.8 1.9 1.7 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EDN06749.1 - 1.5e-09 38.1 0.1 4.1e-09 36.7 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_30 PF13604.6 EDN06749.1 - 0.032 14.0 0.0 0.13 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF3213 PF11491.8 EDN06749.1 - 0.053 13.7 0.1 0.16 12.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) AAA_27 PF13514.6 EDN06749.1 - 0.06 12.9 0.1 0.91 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain RVT_2 PF07727.14 EDN06750.1 - 4e-27 95.4 0.3 3.2e-15 56.4 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06750.1 - 2.6e-11 43.8 0.0 1.3e-10 41.5 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN06750.1 - 1.7e-07 31.0 0.0 4.7e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN06750.1 - 0.00023 20.8 0.0 0.00044 19.9 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN06750.1 - 0.00027 20.5 0.0 0.00064 19.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) rve_3 PF13683.6 EDN06750.1 - 0.06 13.1 0.0 0.2 11.5 0.0 2.0 1 0 0 1 1 1 0 Integrase core domain CALM_bind PF16025.5 EDN06750.1 - 0.46 11.0 3.4 0.23 12.0 0.4 2.1 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding RVT_2 PF07727.14 EDN06752.1 - 1.3e-27 97.1 0.2 1.9e-15 57.2 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06752.1 - 1.1e-11 45.0 0.0 7.5e-11 42.3 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN06752.1 - 1.3e-07 31.4 0.0 2.9e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF4219 PF13961.6 EDN06752.1 - 0.00013 21.6 0.0 0.00039 20.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) Retrotran_gag_2 PF14223.6 EDN06752.1 - 0.00014 21.5 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve_3 PF13683.6 EDN06752.1 - 0.042 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain CALM_bind PF16025.5 EDN06752.1 - 0.08 13.4 0.3 0.2 12.1 0.3 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding FXMRP1_C_core PF12235.8 EDN06752.1 - 8.5 7.0 6.2 19 5.9 6.2 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal RSN1_7TM PF02714.15 EDN06753.1 - 1.8e-88 296.4 23.8 1.8e-88 296.4 23.8 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EDN06753.1 - 2.1e-32 112.8 0.2 3.2e-32 112.2 0.2 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDN06753.1 - 2.9e-27 94.6 1.7 4e-27 94.2 0.5 1.9 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter DMA PF03474.14 EDN06753.1 - 0.084 12.5 0.0 0.29 10.8 0.0 1.9 1 0 0 1 1 1 0 DMRTA motif SWIB PF02201.18 EDN06755.1 - 8.1e-24 83.3 0.1 1.8e-23 82.2 0.1 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EDN06755.1 - 1.1e-13 50.9 0.8 2.6e-13 49.6 0.4 1.9 2 0 0 2 2 2 1 DEK C terminal domain Eno-Rase_FAD_bd PF07055.12 EDN06755.1 - 0.1 13.1 0.0 7.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain ORC6 PF05460.13 EDN06755.1 - 0.37 10.0 11.1 0.56 9.4 11.1 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ndc1_Nup PF09531.10 EDN06755.1 - 7.7 5.1 7.8 9 4.8 7.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup eIF2A PF08662.11 EDN06756.1 - 4.8e-36 124.5 4.8 5.9e-34 117.6 1.7 3.7 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EDN06756.1 - 2e-06 27.5 0.0 5e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP3 PF08572.10 EDN06756.1 - 0.001 18.9 0.3 0.0022 17.8 0.3 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) WD40 PF00400.32 EDN06756.1 - 0.0057 17.5 1.0 1 10.4 0.1 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat DLH PF01738.18 EDN06757.1 - 9.4e-09 35.1 0.0 1.4e-08 34.6 0.0 1.3 1 1 0 1 1 1 1 Dienelactone hydrolase family NmrA PF05368.13 EDN06758.1 - 3e-10 40.0 0.1 1.6e-09 37.7 0.1 2.0 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN06758.1 - 2e-05 24.6 0.3 5.5e-05 23.1 0.1 1.9 2 2 1 3 3 3 1 NAD(P)H-binding Peptidase_C41 PF05417.11 EDN06758.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Hepatitis E cysteine protease Velvet PF11754.8 EDN06759.1 - 7.6e-91 304.5 0.0 9.9e-91 304.1 0.0 1.1 1 0 0 1 1 1 1 Velvet factor DGF-1_C PF11040.8 EDN06759.1 - 3.1 7.9 5.5 10 6.2 0.2 2.4 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Far-17a_AIG1 PF04750.14 EDN06760.1 - 7.6e-59 198.4 13.5 8.9e-59 198.2 13.5 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein TMEM213 PF15192.6 EDN06760.1 - 0.31 11.0 0.8 0.46 10.5 0.0 1.7 2 0 0 2 2 2 0 TMEM213 family Pam17 PF08566.10 EDN06761.1 - 5.3e-67 224.8 0.0 8.2e-67 224.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 MetOD2 PF18548.1 EDN06762.1 - 0.056 13.6 0.3 2.1 8.5 0.2 2.8 3 0 0 3 3 3 0 Metanogen output domain 2 Hep_core_N PF08290.11 EDN06762.1 - 0.18 11.8 0.2 0.44 10.6 0.2 1.6 1 0 0 1 1 1 0 Hepatitis core protein, putative zinc finger MFS_1 PF07690.16 EDN06763.1 - 1.3e-31 109.8 21.5 1.8e-31 109.3 21.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DmsC PF04976.12 EDN06763.1 - 0.00085 18.9 1.6 0.0027 17.2 0.1 2.4 2 0 0 2 2 2 1 DMSO reductase anchor subunit (DmsC) Acyl_transf_3 PF01757.22 EDN06763.1 - 0.28 10.2 20.6 0.15 11.1 11.4 2.4 2 1 0 2 2 2 0 Acyltransferase family DDE_1 PF03184.19 EDN06765.1 - 1.8e-30 105.9 0.0 1.1e-29 103.3 0.0 2.2 3 0 0 3 3 3 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN06765.1 - 0.0021 17.8 0.0 0.0055 16.5 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1_7 PF13843.6 EDN06766.1 - 1.5e-16 60.7 2.0 9.1e-16 58.1 2.0 1.9 1 1 0 1 1 1 1 Transposase IS4 adh_short PF00106.25 EDN06770.1 - 3.1e-39 134.5 0.3 3.6e-39 134.3 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN06770.1 - 6.6e-32 110.9 0.7 8.1e-32 110.7 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN06770.1 - 8.5e-11 42.1 0.1 9.6e-11 41.9 0.1 1.0 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDN06770.1 - 1.2e-09 38.0 0.1 2e-09 37.3 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EDN06770.1 - 1.1e-05 24.8 0.0 1.2e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EDN06770.1 - 5.9e-05 22.3 0.0 8e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain DFP PF04127.15 EDN06770.1 - 0.00042 20.2 0.1 0.00062 19.7 0.1 1.3 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein GDP_Man_Dehyd PF16363.5 EDN06770.1 - 0.00084 18.8 0.0 0.0016 18.0 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDN06770.1 - 0.0014 18.6 0.2 0.0016 18.4 0.2 1.1 1 0 0 1 1 1 1 NAD(P)H-binding ADH_zinc_N PF00107.26 EDN06770.1 - 0.0038 17.2 0.2 0.01 15.9 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase NmrA PF05368.13 EDN06770.1 - 0.022 14.3 0.1 0.029 13.9 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family RcsD_ABL PF16359.5 EDN06770.1 - 0.17 12.0 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 RcsD-ABL domain Abhydrolase_1 PF00561.20 EDN06771.1 - 1.2e-14 54.6 0.0 1.8e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN06771.1 - 0.0038 17.9 0.0 0.0046 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN06771.1 - 0.0055 16.0 0.0 0.013 14.7 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Aminotran_4 PF01063.19 EDN06772.1 - 4.9e-22 78.9 0.0 5.9e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Cytokin_check_N PF10407.9 EDN06773.1 - 0.033 14.1 0.2 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus Pkinase PF00069.25 EDN06774.1 - 2e-40 138.9 0.0 2.7e-29 102.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ribonuc_2-5A PF06479.12 EDN06774.1 - 1.4e-37 128.7 0.0 2.4e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 EDN06774.1 - 5.5e-21 75.0 0.0 7.6e-20 71.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EDN06774.1 - 0.0001 22.1 0.1 0.12 12.4 0.0 3.2 3 0 0 3 3 3 2 PQQ enzyme repeat Pkinase_fungal PF17667.1 EDN06774.1 - 0.0087 14.9 0.5 0.026 13.3 0.0 1.9 2 1 1 3 3 3 1 Fungal protein kinase Kdo PF06293.14 EDN06774.1 - 0.017 14.5 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_2 PF13360.6 EDN06774.1 - 0.053 13.1 0.1 0.25 10.9 0.1 2.0 1 1 1 2 2 2 0 PQQ-like domain Cpn60_TCP1 PF00118.24 EDN06775.1 - 3.9e-143 477.6 13.8 4.5e-143 477.4 13.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 EDN06775.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat FlgM PF04316.13 EDN06775.1 - 0.19 12.1 2.1 0.82 10.1 0.0 2.8 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Pro_isomerase PF00160.21 EDN06776.1 - 5.4e-51 173.0 0.0 1e-50 172.1 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EDN06776.1 - 9.3e-09 35.8 0.3 0.11 13.4 0.0 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Miga PF10265.9 EDN06777.1 - 0.03 13.3 0.0 0.034 13.2 0.0 1.1 1 0 0 1 1 1 0 Mitoguardin TAS2R PF05296.13 EDN06777.1 - 0.036 13.2 0.0 0.048 12.8 0.0 1.1 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) LapA_dom PF06305.11 EDN06777.1 - 0.066 13.0 0.7 0.12 12.2 0.7 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain NICE-3 PF07406.11 EDN06777.1 - 0.093 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 NICE-3 protein DUF2207 PF09972.9 EDN06777.1 - 0.14 10.9 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AA_permease PF00324.21 EDN06778.1 - 1.8e-64 218.1 24.5 1e-62 212.3 20.3 2.3 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EDN06778.1 - 1.6e-15 56.9 19.5 2.3e-15 56.4 19.5 1.1 1 0 0 1 1 1 1 Amino acid permease SPC12 PF06645.13 EDN06778.1 - 0.053 13.6 2.6 0.5 10.5 1.3 2.9 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) p450 PF00067.22 EDN06779.1 - 1e-51 176.2 0.0 1.3e-51 175.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 EABR PF12180.8 EDN06779.1 - 0.074 12.7 2.1 0.31 10.7 0.3 2.3 2 0 0 2 2 2 0 TSG101 and ALIX binding domain of CEP55 p450 PF00067.22 EDN06781.1 - 1.1e-37 129.9 0.0 1.6e-37 129.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MoaE PF02391.17 EDN06781.1 - 6.6e-33 113.4 0.0 9.6e-33 112.8 0.0 1.2 1 0 0 1 1 1 1 MoaE protein Herpes_UL32 PF06070.11 EDN06781.1 - 0.027 12.3 0.1 0.037 11.8 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 DUF775 PF05603.12 EDN06783.1 - 1.7e-64 217.1 0.1 1.9e-64 216.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Aldedh PF00171.22 EDN06784.1 - 6e-119 397.6 0.0 7.5e-119 397.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Clostridium_P47 PF06597.11 EDN06785.1 - 0.03 13.1 2.3 0.032 13.0 2.3 1.0 1 0 0 1 1 1 0 Clostridium P-47 protein DUF5591 PF17884.1 EDN06786.1 - 0.0032 17.3 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5591) FBPase PF00316.20 EDN06792.1 - 2.5e-69 232.6 0.0 3.1e-69 232.2 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain FAD_binding_2 PF00890.24 EDN06793.1 - 1.5e-62 212.1 0.1 2.2e-62 211.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EDN06793.1 - 1.2e-21 76.6 0.4 3.5e-20 71.9 0.1 2.8 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EDN06793.1 - 0.00066 19.4 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EDN06793.1 - 0.0074 15.6 0.0 0.22 10.8 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EDN06793.1 - 0.011 15.0 0.0 0.07 12.3 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase P_proprotein PF01483.20 EDN06793.1 - 0.15 12.1 0.2 9.7 6.3 0.0 2.5 2 0 0 2 2 2 0 Proprotein convertase P-domain GDPD PF03009.17 EDN06794.1 - 1.3e-33 116.9 0.0 3.1e-33 115.6 0.0 1.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EDN06794.1 - 0.0021 18.4 0.0 0.0066 16.9 0.0 1.9 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family RIX1 PF08167.12 EDN06794.1 - 0.0032 17.2 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis DUF865 PF05906.11 EDN06795.1 - 7.6 6.4 8.2 3.3 7.6 3.6 2.4 2 0 0 2 2 2 0 Herpesvirus-7 repeat of unknown function (DUF865) Zip PF02535.22 EDN06796.1 - 2.7e-61 207.6 4.5 7.8e-60 202.8 4.5 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter IGPD PF00475.18 EDN06796.1 - 1.1e-43 149.0 0.1 2e-43 148.1 0.1 1.5 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase DUF456 PF04306.13 EDN06796.1 - 3.5 7.9 15.5 1.4 9.2 0.8 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF456) Anp1 PF03452.14 EDN06797.1 - 6.1e-107 356.9 0.0 7.2e-107 356.7 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EDN06797.1 - 0.0015 18.4 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 RT_RNaseH PF17917.1 EDN06798.1 - 1.1e-45 154.3 0.5 5.5e-45 152.0 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN06798.1 - 4.8e-33 114.5 0.1 8.1e-33 113.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN06798.1 - 1.9e-27 95.2 0.0 3.8e-14 52.5 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06798.1 - 1e-20 73.6 0.4 2.2e-20 72.5 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN06798.1 - 1.1e-15 57.2 0.5 3.2e-15 55.8 0.5 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN06798.1 - 7.6e-07 29.3 0.0 1.9e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN06798.1 - 0.0001 22.4 0.1 0.00025 21.2 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 EDN06798.1 - 0.057 14.1 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 EDN06798.1 - 0.13 12.9 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease GFA PF04828.14 EDN06799.1 - 8.7e-17 61.2 1.4 2.5e-08 34.1 0.0 3.6 2 2 1 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme WD40 PF00400.32 EDN06800.1 - 3.3e-16 59.4 18.9 2.2e-06 28.3 0.6 9.4 9 0 0 9 9 9 3 WD domain, G-beta repeat UnbV_ASPIC PF07593.12 EDN06800.1 - 0.15 12.1 0.0 3.9 7.5 0.0 2.6 2 0 0 2 2 2 0 ASPIC and UnbV DUF778 PF05608.12 EDN06801.1 - 0.15 12.4 0.2 0.29 11.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF778) HpcH_HpaI PF03328.14 EDN06803.1 - 2.1e-37 128.4 0.2 2.7e-35 121.5 0.0 2.7 2 1 0 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EDN06803.1 - 3.4e-11 42.9 0.1 2.3e-07 30.3 0.0 2.3 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold F-box PF00646.33 EDN06804.1 - 0.00013 21.8 0.0 0.00033 20.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN06804.1 - 0.0022 17.8 0.1 0.0075 16.1 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EDN06804.1 - 0.012 15.5 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 F-box Mur_ligase_M PF08245.12 EDN06804.1 - 0.089 12.8 0.1 0.2 11.6 0.1 1.6 1 1 0 1 1 1 0 Mur ligase middle domain Ric8 PF10165.9 EDN06805.1 - 9.6e-106 354.6 0.0 1.2e-105 354.3 0.0 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Transket_pyr PF02779.24 EDN06806.1 - 8.4e-41 139.6 0.0 1.3e-40 139.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDN06806.1 - 1.1e-31 109.3 0.0 2.3e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain XPG_N PF00752.17 EDN06807.1 - 4.3e-35 120.2 0.0 1.5e-34 118.5 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDN06807.1 - 4.6e-26 91.0 0.0 1.6e-25 89.3 0.0 2.0 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EDN06807.1 - 0.00095 19.7 0.0 0.003 18.1 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EDN06807.1 - 0.12 13.0 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain UIM PF02809.20 EDN06807.1 - 3.5 7.7 7.3 0.14 12.2 0.8 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif AAA_23 PF13476.6 EDN06807.1 - 5.6 7.4 14.1 0.045 14.3 2.3 3.1 3 0 0 3 3 3 0 AAA domain adh_short PF00106.25 EDN06808.1 - 2e-31 109.0 0.0 2.9e-31 108.4 0.0 1.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN06808.1 - 6.3e-22 78.3 0.0 1.3e-21 77.2 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN06808.1 - 0.023 14.6 0.0 0.076 12.9 0.0 1.8 1 1 0 1 1 1 0 KR domain FlxA PF14282.6 EDN06809.1 - 0.019 14.9 5.7 0.087 12.8 4.2 2.1 2 0 0 2 2 2 0 FlxA-like protein DUF3375 PF11855.8 EDN06809.1 - 0.032 13.2 7.3 0.043 12.7 4.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) RVT_1 PF00078.27 EDN06810.1 - 4e-25 88.6 0.0 6.6e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN06810.1 - 0.036 13.8 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Integrase_H2C2 PF17921.1 EDN06811.1 - 3.3e-17 62.3 0.1 5.3e-17 61.7 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EDN06811.1 - 0.18 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 H2C2 zinc finger Inhibitor_I78 PF11720.8 EDN06813.1 - 3.9e-12 46.0 0.0 5.1e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EDN06813.1 - 2.8e-05 24.7 0.0 3.6e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Potato inhibitor I family Nefa_Nip30_N PF10187.9 EDN06814.1 - 3.5e-33 114.1 13.3 3.5e-33 114.1 13.3 1.8 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF2075 PF09848.9 EDN06814.1 - 0.03 13.6 2.0 0.04 13.2 2.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF2570 PF10828.8 EDN06814.1 - 0.58 10.0 3.9 1 9.2 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) LCD1 PF09798.9 EDN06814.1 - 1.9 6.9 7.7 2.4 6.6 7.7 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein CK_II_beta PF01214.18 EDN06815.1 - 2.5e-76 255.6 0.0 3.3e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CxC5 PF18718.1 EDN06815.1 - 0.14 12.3 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases FAD_binding_4 PF01565.23 EDN06817.1 - 7.9e-23 80.7 0.1 1.7e-22 79.6 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EDN06817.1 - 1.5e-09 37.8 0.0 2.7e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like Dabb PF07876.12 EDN06818.1 - 4.9e-14 52.7 0.1 5.2e-14 52.6 0.1 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Fungal_trans_2 PF11951.8 EDN06819.1 - 3.8e-28 98.4 0.1 6.2e-28 97.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain PAD PF03068.15 EDN06820.1 - 1.1e-54 186.0 0.0 1.3e-54 185.7 0.0 1.0 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) IglC PF11550.8 EDN06821.1 - 0.00081 18.9 0.4 0.00087 18.8 0.4 1.1 1 0 0 1 1 1 1 Intracellular growth locus C protein Abhydrolase_3 PF07859.13 EDN06822.1 - 2.6e-05 24.2 0.0 0.15 11.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN06822.1 - 0.0059 17.2 0.1 0.0082 16.8 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN06822.1 - 0.022 14.4 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EDN06822.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) JAB PF01398.21 EDN06823.1 - 2.5e-08 33.9 0.6 3.4e-07 30.3 0.6 2.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HMG_box PF00505.19 EDN06825.1 - 1.8e-10 41.1 13.8 2.6e-10 40.6 2.5 3.8 3 1 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EDN06825.1 - 2.1e-09 37.9 3.9 2.1e-09 37.9 3.9 4.3 4 2 0 4 4 4 1 HMG-box domain Protamine_like PF06382.11 EDN06825.1 - 0.0001 22.5 0.5 0.0001 22.5 0.5 2.5 2 0 0 2 2 2 1 Protamine and protamine like Endostatin PF06482.11 EDN06825.1 - 0.092 12.2 3.5 0.16 11.4 3.5 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Adaptin_binding PF10199.9 EDN06825.1 - 0.58 10.8 6.9 0.12 13.0 3.2 1.8 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Hamartin PF04388.12 EDN06825.1 - 0.6 8.7 11.5 0.71 8.5 11.5 1.0 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 EDN06825.1 - 2.5 6.7 7.0 2.4 6.7 7.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Helicase_C PF00271.31 EDN06826.1 - 9.3e-27 93.6 0.0 2e-26 92.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN06826.1 - 2.9e-14 53.2 0.0 2.7e-13 50.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase WLM PF08325.10 EDN06827.1 - 1.5 8.9 7.0 0.37 10.8 0.2 2.0 1 1 1 2 2 2 0 WLM domain zf-C2H2 PF00096.26 EDN06829.1 - 2.1e-19 68.8 45.9 1.1e-06 28.7 0.8 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN06829.1 - 7.2e-16 57.8 42.4 2.4e-08 34.0 0.8 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN06829.1 - 8.2e-13 48.0 41.3 0.00027 21.5 0.7 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.7 EDN06829.1 - 3.4e-10 39.9 9.9 0.00081 19.7 0.6 4.0 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EDN06829.1 - 1.7e-06 27.6 22.9 0.14 12.0 0.1 5.9 5 1 0 5 5 5 3 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EDN06829.1 - 3e-05 24.2 3.6 0.0024 18.1 0.1 5.5 8 0 0 8 8 5 3 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EDN06829.1 - 0.0004 20.9 0.4 0.0004 20.9 0.4 4.9 3 2 2 5 5 5 1 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EDN06829.1 - 0.002 17.8 20.2 0.018 14.8 1.9 4.0 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 EDN06829.1 - 0.024 14.6 23.4 0.53 10.4 2.8 5.1 5 0 0 5 5 5 0 C2H2-type zinc finger zf-MYST PF17772.1 EDN06829.1 - 0.051 13.2 8.7 1.2 8.8 0.1 3.9 4 0 0 4 4 4 0 MYST family zinc finger domain zf-C2H2_2 PF12756.7 EDN06829.1 - 0.7 10.3 23.2 0.66 10.3 0.8 4.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF1390 PF07150.11 EDN06829.1 - 3.6 7.2 6.4 0.72 9.5 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1390) AMP-binding_C PF13193.6 EDN06830.1 - 0.00043 21.2 0.1 0.0059 17.6 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Herpes_UL51 PF04540.13 EDN06830.1 - 0.07 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL51 protein AMP-binding PF00501.28 EDN06830.1 - 0.091 11.3 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 AMP-binding enzyme DBD_Tnp_Hermes PF10683.9 EDN06831.1 - 0.053 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain GLE1 PF07817.13 EDN06831.1 - 0.097 11.9 0.1 0.21 10.8 0.1 1.5 1 0 0 1 1 1 0 GLE1-like protein zf-C2H2 PF00096.26 EDN06832.1 - 3.8e-06 27.1 12.7 9.8e-05 22.6 4.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN06832.1 - 1.1e-05 25.6 2.8 1.1e-05 25.6 2.8 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN06832.1 - 0.0012 19.5 9.5 0.0016 19.1 2.1 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 EDN06832.1 - 0.0018 18.6 8.0 0.0036 17.6 0.6 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDN06832.1 - 0.0027 17.7 1.1 0.0027 17.7 1.1 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 EDN06832.1 - 0.017 15.4 5.2 0.032 14.5 5.2 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF2225 PF09986.9 EDN06832.1 - 0.019 14.7 0.2 0.034 13.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_jaz PF12171.8 EDN06832.1 - 0.022 15.1 0.6 0.056 13.7 0.6 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding BolA PF01722.18 EDN06832.1 - 0.13 12.5 0.9 0.25 11.6 0.9 1.4 1 0 0 1 1 1 0 BolA-like protein Kelch_6 PF13964.6 EDN06833.1 - 7.3e-05 22.9 7.4 0.0024 18.1 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EDN06833.1 - 0.00022 20.7 0.8 0.1 12.2 0.0 3.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 EDN06833.1 - 0.00059 19.8 2.5 0.39 10.8 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Suf PF05843.14 EDN06835.1 - 0.011 15.8 0.4 0.015 15.3 0.4 1.3 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) Vint PF14623.6 EDN06838.1 - 4.1e-61 205.6 0.0 6.6e-61 205.0 0.0 1.3 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EDN06838.1 - 1.8e-24 85.6 0.0 3.6e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA PF00092.28 EDN06838.1 - 2.9e-16 60.2 0.0 9.1e-16 58.6 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 EDN06838.1 - 1.1e-15 57.9 0.0 6.7e-13 48.9 0.0 3.7 3 1 0 3 3 3 1 von Willebrand factor type A domain VWA_2 PF13519.6 EDN06838.1 - 8e-15 55.4 0.0 7.1e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain Ldh_1_C PF02866.18 EDN06838.1 - 0.17 11.8 0.1 3.5 7.5 0.0 2.2 2 0 0 2 2 2 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Aldo_ket_red PF00248.21 EDN06839.1 - 5.1e-58 196.6 0.0 5.8e-58 196.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PEP_hydrolase PF09370.10 EDN06840.1 - 4.8e-135 448.9 0.5 5.4e-135 448.8 0.5 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 EDN06840.1 - 0.011 15.1 0.2 0.011 15.1 0.2 1.8 2 0 0 2 2 2 0 Nitronate monooxygenase AdoHcyase PF05221.17 EDN06841.1 - 3.2e-126 420.5 0.0 1e-72 244.8 0.4 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase UPF0261 PF06792.11 EDN06841.1 - 6.3e-90 302.0 0.0 9.7e-90 301.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) AdoHcyase_NAD PF00670.21 EDN06841.1 - 8.7e-84 279.5 1.8 1.7e-83 278.6 1.8 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDN06841.1 - 3e-07 30.0 0.5 9.5e-07 28.3 0.2 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDN06841.1 - 0.002 17.7 0.1 0.0042 16.7 0.1 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EDN06841.1 - 0.0059 16.9 0.2 0.043 14.1 0.1 2.3 2 0 0 2 2 2 1 TrkA-N domain ELFV_dehydrog PF00208.21 EDN06841.1 - 0.02 14.6 0.4 0.041 13.6 0.4 1.5 1 1 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase MFS_1 PF07690.16 EDN06842.1 - 1e-46 159.5 40.4 4.7e-40 137.6 26.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EDN06842.1 - 0.048 12.0 16.1 0.044 12.1 6.0 3.5 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family FUN14 PF04930.15 EDN06842.1 - 0.4 11.1 3.2 0.81 10.1 0.0 3.0 3 0 0 3 3 3 0 FUN14 family MFS_3 PF05977.13 EDN06842.1 - 7.5 4.8 21.9 0.048 12.1 6.3 2.6 2 2 0 2 2 2 0 Transmembrane secretion effector Beta-lactamase PF00144.24 EDN06843.1 - 3.4e-45 154.7 0.0 5e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EDN06843.1 - 0.19 11.1 0.1 0.41 10.0 0.0 1.5 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase VbhA PF18495.1 EDN06843.1 - 0.22 11.4 0.0 0.4 10.6 0.0 1.4 1 0 0 1 1 1 0 Antitoxin VbhA zf-H2C2_2 PF13465.6 EDN06845.1 - 1e-07 32.1 12.2 1.5e-06 28.4 1.0 3.8 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDN06845.1 - 1.4e-07 31.6 6.0 1e-06 28.9 0.8 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 EDN06845.1 - 1.1e-06 29.1 7.3 0.035 14.8 0.1 3.3 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EDN06845.1 - 1.3e-06 28.3 1.3 0.0012 18.7 0.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDN06845.1 - 0.00014 22.4 8.1 0.00064 20.3 0.5 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EDN06845.1 - 0.016 14.9 2.8 0.077 12.8 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 EDN06845.1 - 0.093 12.5 0.7 0.25 11.1 0.1 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EDN06845.1 - 0.18 12.1 4.1 0.48 10.8 0.3 3.3 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EDN06845.1 - 0.22 11.7 1.0 4.4 7.4 0.0 2.2 1 1 0 2 2 2 0 Aberrant zinc-finger Zap1_zf2 PF18217.1 EDN06845.1 - 0.57 10.2 10.3 5.6 7.1 1.0 2.7 2 1 0 2 2 2 0 Zap1 zinc finger 2 SNF2_N PF00176.23 EDN06846.1 - 8.5e-56 189.2 0.0 1.4e-55 188.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.6 EDN06846.1 - 1.4e-21 76.7 0.4 1.2e-20 73.7 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Chromo PF00385.24 EDN06846.1 - 6.4e-21 74.0 1.1 3.1e-12 46.2 0.2 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EDN06846.1 - 1.1e-17 64.4 0.0 3e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cdh1_DBD_1 PF18196.1 EDN06846.1 - 4.7e-09 36.6 17.4 7.2e-08 32.8 0.7 4.4 3 1 1 4 4 4 2 Chromodomain helicase DNA-binding domain 1 ResIII PF04851.15 EDN06846.1 - 6e-07 29.6 0.0 2.1e-05 24.6 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EDN06846.1 - 0.0027 17.9 0.2 0.015 15.4 0.0 2.4 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain SLIDE PF09111.10 EDN06846.1 - 0.021 14.9 0.0 0.12 12.4 0.0 2.4 1 1 0 1 1 1 0 SLIDE CDH1_2_SANT_HL1 PF18375.1 EDN06846.1 - 1.2 9.8 4.2 1.2 9.8 0.2 2.9 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 zf-C2H2 PF00096.26 EDN06847.1 - 0.0054 17.1 0.2 5.3 7.7 0.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN06847.1 - 2 9.5 8.1 2.7 9.1 0.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Pkinase_fungal PF17667.1 EDN06848.1 - 1.5e-141 471.9 0.0 1.9e-141 471.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN06848.1 - 2.7e-07 30.2 0.0 4.6e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06848.1 - 0.004 16.5 0.0 0.0067 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN06848.1 - 0.086 12.7 0.0 0.22 11.4 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Myb_DNA-binding PF00249.31 EDN06849.1 - 0.0032 17.6 0.0 0.0052 16.9 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN06849.1 - 0.008 16.4 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain ABC_tran PF00005.27 EDN06851.1 - 6.4e-35 120.6 0.0 1.6e-17 64.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDN06851.1 - 1.1e-11 44.6 2.0 0.0019 17.7 0.0 4.0 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDN06851.1 - 9.1e-11 42.1 5.8 0.0066 16.3 0.0 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EDN06851.1 - 4.7e-06 26.6 0.1 0.023 14.6 0.0 2.5 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_22 PF13401.6 EDN06851.1 - 1.7e-05 25.1 0.3 0.0049 17.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EDN06851.1 - 2.7e-05 24.1 0.0 0.21 11.3 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 EDN06851.1 - 3.9e-05 24.1 0.0 0.055 13.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN06851.1 - 0.0001 22.7 0.0 0.19 12.1 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDN06851.1 - 0.0002 21.3 0.0 0.71 9.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDN06851.1 - 0.00074 19.2 0.2 0.63 9.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_7 PF12775.7 EDN06851.1 - 0.0013 18.3 0.2 0.026 14.0 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 EDN06851.1 - 0.0015 18.3 2.1 0.092 12.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDN06851.1 - 0.0015 19.1 0.0 3.6 8.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDN06851.1 - 0.0023 18.3 0.1 1.1 9.7 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_13 PF13166.6 EDN06851.1 - 0.0026 16.5 0.1 0.0072 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EDN06851.1 - 0.0036 17.8 0.2 0.69 10.4 0.4 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDN06851.1 - 0.0058 16.8 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EDN06851.1 - 0.0067 16.1 3.0 0.14 11.8 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain TsaE PF02367.17 EDN06851.1 - 0.012 15.6 0.1 0.15 12.0 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EDN06851.1 - 0.013 15.7 0.1 2.1 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EDN06851.1 - 0.014 14.5 0.0 1.1 8.4 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain VirE PF05272.11 EDN06851.1 - 0.017 14.9 0.0 6.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E Thymidylate_kin PF02223.17 EDN06851.1 - 0.018 14.8 0.2 12 5.5 0.0 3.0 3 0 0 3 3 3 0 Thymidylate kinase NACHT PF05729.12 EDN06851.1 - 0.028 14.3 2.8 1.5 8.7 0.1 2.9 3 0 0 3 3 3 0 NACHT domain AAA_30 PF13604.6 EDN06851.1 - 0.047 13.4 0.4 3.5 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN06851.1 - 0.12 12.4 0.2 7.2 6.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EDN06851.1 - 0.13 11.6 0.2 0.41 9.9 0.1 1.9 2 0 0 2 2 2 0 KaiC PduV-EutP PF10662.9 EDN06851.1 - 0.13 12.0 2.6 0.17 11.6 0.1 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.11 EDN06851.1 - 0.16 10.7 0.0 0.31 9.8 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) NTPase_1 PF03266.15 EDN06851.1 - 1.7 8.5 3.3 21 5.0 0.1 2.9 3 0 0 3 3 3 0 NTPase FF PF01846.19 EDN06852.1 - 5.7e-54 180.1 16.8 2.2e-15 56.6 1.2 7.3 6 1 0 6 6 6 6 FF domain WW PF00397.26 EDN06852.1 - 1.5e-17 63.4 15.2 2.3e-09 37.1 1.5 2.7 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 EDN06852.1 - 0.056 14.1 8.7 1.8 9.3 0.1 4.5 3 1 1 4 4 4 0 p190-A and -B Rho GAPs FF domain HycH PF07450.11 EDN06852.1 - 0.36 11.2 0.9 0.98 9.8 0.9 1.8 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH Glyco_hyd_101C PF17451.2 EDN06852.1 - 1.3 9.3 7.7 7.9 6.8 0.2 2.8 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Trs65 PF12735.7 EDN06853.1 - 5.9e-80 269.0 0.0 8.1e-80 268.6 0.0 1.2 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Mpv17_PMP22 PF04117.12 EDN06854.1 - 1e-20 73.7 0.2 3.1e-20 72.2 0.2 1.9 1 0 0 1 1 1 1 Mpv17 / PMP22 family DAD PF02109.16 EDN06854.1 - 0.038 14.3 0.3 3.6 7.9 0.0 2.5 2 0 0 2 2 2 0 DAD family PGK PF00162.19 EDN06855.1 - 4.1e-146 486.8 0.0 4.6e-146 486.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF3530 PF12048.8 EDN06855.1 - 0.018 14.5 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Dioxygenase_C PF00775.21 EDN06856.1 - 1.8e-39 135.1 0.0 2.3e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EDN06856.1 - 2.9e-24 84.7 0.0 4.6e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Lactonase PF10282.9 EDN06857.1 - 7.6e-19 68.2 0.1 2.7e-18 66.4 0.1 1.7 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF3375 PF11855.8 EDN06858.1 - 0.031 13.2 7.3 0.043 12.7 4.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) FlxA PF14282.6 EDN06858.1 - 0.055 13.5 7.5 0.24 11.4 5.9 2.1 2 0 0 2 2 2 0 FlxA-like protein FUSC PF04632.12 EDN06858.1 - 2 6.9 3.0 2.7 6.4 3.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family RT_RNaseH PF17917.1 EDN06859.1 - 1.5e-36 124.9 0.0 2.9e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN06859.1 - 4.3e-32 110.1 0.0 9.7e-32 109.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06859.1 - 6e-20 71.1 0.3 1.5e-19 69.9 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 EDN06859.1 - 1.5e-15 57.3 0.1 1e-13 51.3 0.0 2.3 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06859.1 - 2.4e-12 47.1 0.0 7.3e-12 45.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN06859.1 - 0.0015 18.7 0.0 0.0032 17.7 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Chromo PF00385.24 EDN06860.1 - 0.0035 17.2 0.0 0.018 14.9 0.0 2.1 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase_fungal PF17667.1 EDN06861.1 - 2e-142 474.8 0.0 2.5e-142 474.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN06861.1 - 3.6e-07 29.8 0.0 6.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06861.1 - 0.021 14.1 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN06861.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family BCS1_N PF08740.11 EDN06862.1 - 5.7e-35 121.0 0.0 9.5e-35 120.3 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN06862.1 - 3.5e-20 72.8 0.0 1.5e-19 70.7 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN06862.1 - 6.6e-05 23.4 0.0 0.00016 22.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 EDN06862.1 - 0.029 13.7 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EDN06862.1 - 0.033 13.8 0.0 0.084 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN06862.1 - 0.04 14.1 0.0 1.6 8.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EDN06862.1 - 0.047 12.5 0.0 0.097 11.5 0.0 1.5 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 EDN06862.1 - 0.09 12.5 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN06862.1 - 0.15 12.1 0.0 0.41 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Myb_DNA-binding PF00249.31 EDN06863.1 - 8.2e-14 51.5 2.5 3.9e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN06863.1 - 3.3e-06 27.3 0.5 0.0011 19.2 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain WRC PF08879.10 EDN06864.1 - 0.0091 15.7 0.3 0.0091 15.7 0.3 1.6 2 0 0 2 2 2 1 WRC DDE_1 PF03184.19 EDN06865.1 - 2.2e-29 102.4 0.0 4.3e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN06865.1 - 0.0012 18.6 0.0 0.0077 16.0 0.0 2.2 2 0 0 2 2 2 1 DDE superfamily endonuclease Helo_like_N PF17111.5 EDN06866.1 - 1.2e-84 282.9 6.5 9.3e-73 244.0 0.4 2.7 2 1 0 2 2 2 2 Fungal N-terminal domain of STAND proteins DUF16 PF01519.16 EDN06866.1 - 0.0012 19.3 4.5 0.18 12.3 0.6 3.3 3 0 0 3 3 3 1 Protein of unknown function DUF16 PIN_8 PF18476.1 EDN06866.1 - 0.0043 16.9 4.1 0.31 10.9 1.4 2.8 3 1 0 3 3 3 1 PIN like domain Rx_N PF18052.1 EDN06866.1 - 0.0067 16.7 6.1 1.2 9.4 0.0 3.6 3 1 0 3 3 3 1 Rx N-terminal domain DUF3502 PF12010.8 EDN06866.1 - 0.031 14.9 0.4 2.8 8.6 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3502) RPAP2_Rtr1 PF04181.13 EDN06866.1 - 0.056 13.8 0.1 12 6.3 0.0 2.5 2 0 0 2 2 2 0 Rtr1/RPAP2 family Baculo_PEP_C PF04513.12 EDN06866.1 - 0.056 13.5 3.8 8 6.5 0.4 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HWE_HK PF07536.14 EDN06866.1 - 0.061 14.0 3.9 0.15 12.8 1.3 2.7 2 1 1 3 3 3 0 HWE histidine kinase Syntaxin PF00804.25 EDN06866.1 - 0.18 11.5 4.6 0.13 12.0 0.6 2.5 3 0 0 3 3 3 0 Syntaxin Myc-LZ PF02344.15 EDN06866.1 - 0.24 11.6 3.5 0.72 10.0 1.7 2.5 2 0 0 2 2 2 0 Myc leucine zipper domain Salp15 PF12115.8 EDN06866.1 - 0.24 11.8 1.8 10 6.6 0.5 2.5 2 0 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Uso1_p115_C PF04871.13 EDN06866.1 - 0.24 11.7 10.2 2.5 8.5 4.3 3.1 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1845 PF08900.11 EDN06866.1 - 0.4 10.4 2.6 8.4 6.1 0.7 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1845) Exonuc_VII_L PF02601.15 EDN06866.1 - 0.78 9.3 6.7 23 4.4 6.7 2.7 1 1 1 2 2 2 0 Exonuclease VII, large subunit YlqD PF11068.8 EDN06866.1 - 0.85 10.0 10.5 10 6.5 4.2 3.0 3 0 0 3 3 3 0 YlqD protein DUF1640 PF07798.11 EDN06866.1 - 0.96 9.5 9.3 5.6 7.0 0.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF1640) Med9 PF07544.13 EDN06866.1 - 1.3 9.2 5.3 25 5.0 0.0 3.4 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 ING PF12998.7 EDN06866.1 - 1.4 9.5 5.2 0.47 11.1 0.3 2.6 3 0 0 3 3 2 0 Inhibitor of growth proteins N-terminal histone-binding UPF0172 PF03665.13 EDN06866.1 - 1.4 8.9 6.2 2.9 7.9 1.5 2.4 3 0 0 3 3 2 0 Uncharacterised protein family (UPF0172) DUF3391 PF11871.8 EDN06866.1 - 2.1 8.9 5.7 41 4.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) HIP1_clath_bdg PF16515.5 EDN06866.1 - 2.5 8.8 12.5 63 4.3 0.2 3.4 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Syntaxin-6_N PF09177.11 EDN06866.1 - 6.8 7.3 16.2 21 5.7 3.9 3.9 2 1 1 4 4 3 0 Syntaxin 6, N-terminal COG2 PF06148.11 EDN06866.1 - 7.3 6.7 8.2 16 5.6 2.8 3.3 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3435 PF11917.8 EDN06867.1 - 7.1e-115 384.3 1.2 6.3e-82 275.7 0.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) zf-C2H2_4 PF13894.6 EDN06867.1 - 0.068 14.0 6.5 2.5 9.2 0.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EDN06867.1 - 0.13 12.9 0.6 0.36 11.5 0.6 1.7 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats DDE_1 PF03184.19 EDN06868.1 - 8e-23 81.0 0.0 1.8e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN06868.1 - 6.8e-05 22.6 0.1 0.00091 19.0 0.0 2.6 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06868.1 - 0.0015 18.5 0.0 0.0063 16.5 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN06868.1 - 0.028 14.2 0.5 0.028 14.2 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN06868.1 - 0.046 13.2 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) Borrelia_P83 PF05262.11 EDN06868.1 - 4.1 5.8 21.4 6.6 5.1 21.4 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Abhydrolase_6 PF12697.7 EDN06869.1 - 5.2e-12 46.9 0.4 1.2e-11 45.7 0.4 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN06869.1 - 9.6e-09 35.2 0.0 2e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN06869.1 - 0.0021 17.3 0.0 0.0045 16.3 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Erythro-docking PF09277.11 EDN06869.1 - 0.018 14.9 0.2 0.067 13.1 0.1 2.0 2 0 0 2 2 2 0 Erythronolide synthase, docking Esterase PF00756.20 EDN06869.1 - 0.02 14.6 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative esterase EthD PF07110.11 EDN06869.1 - 0.03 15.4 0.2 11 7.2 0.0 2.8 3 0 0 3 3 3 0 EthD domain Ndr PF03096.14 EDN06869.1 - 0.037 12.7 0.0 0.084 11.6 0.0 1.6 1 1 0 1 1 1 0 Ndr family DSS1_SEM1 PF05160.13 EDN06870.1 - 8.2e-23 80.2 17.9 1.1e-22 79.9 17.9 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.12 EDN06870.1 - 0.01 15.6 6.7 0.012 15.4 6.7 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nuc_deoxyri_tr2 PF15891.5 EDN06870.1 - 1.1 9.6 4.6 0.45 10.8 2.3 1.6 1 1 1 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like DUF3808 PF10300.9 EDN06872.1 - 2.6e-121 405.7 0.6 3.3e-121 405.4 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) MFS_1 PF07690.16 EDN06872.1 - 1.2e-20 73.8 24.8 4.7e-19 68.5 14.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN06872.1 - 1.1e-05 24.5 4.5 1.1e-05 24.5 4.5 2.5 3 1 0 3 3 3 1 Sugar (and other) transporter DUF5098 PF17023.5 EDN06872.1 - 0.014 14.4 0.1 0.024 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) UPF0565 PF10561.9 EDN06872.1 - 0.074 12.2 0.0 0.29 10.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Rad51 PF08423.11 EDN06873.1 - 2e-101 338.5 0.1 1.2e-54 185.3 0.3 2.0 1 1 1 2 2 2 2 Rad51 RecA PF00154.21 EDN06873.1 - 2.3e-06 27.3 0.2 0.00068 19.2 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein HHH_5 PF14520.6 EDN06873.1 - 1.1e-05 25.9 0.4 4.2e-05 24.1 0.1 2.1 2 1 0 2 2 2 1 Helix-hairpin-helix domain AAA_25 PF13481.6 EDN06873.1 - 1.2e-05 25.0 0.0 2.6e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 EDN06873.1 - 0.00047 19.6 0.1 0.00097 18.5 0.1 1.5 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EDN06873.1 - 0.0097 15.3 0.0 0.026 13.9 0.0 1.7 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 EDN06873.1 - 0.011 14.9 0.3 0.35 10.0 0.1 2.1 2 0 0 2 2 2 0 PAXNEB protein Nup160 PF11715.8 EDN06874.1 - 1.2e-109 367.4 5.6 2.1e-83 280.8 1.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF3237 PF11578.8 EDN06875.1 - 0.03 14.2 0.1 0.039 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3237) HAT_KAT11 PF08214.11 EDN06875.1 - 0.075 12.3 0.0 0.08 12.2 0.0 1.0 1 0 0 1 1 1 0 Histone acetylation protein Protamine_P2 PF00841.19 EDN06876.1 - 0.058 13.9 0.8 0.058 13.9 0.8 1.8 2 0 0 2 2 2 0 Sperm histone P2 NICE-1 PF15845.5 EDN06876.1 - 0.065 14.0 1.0 0.096 13.5 0.1 1.7 2 0 0 2 2 2 0 Cysteine-rich C-terminal 1 family CPL PF08144.11 EDN06877.1 - 7.3e-24 84.7 0.0 3.4e-21 76.1 0.0 3.3 2 1 1 3 3 3 2 CPL (NUC119) domain PUF PF00806.19 EDN06877.1 - 0.00077 19.0 0.1 3.8 7.4 0.0 4.0 4 0 0 4 4 4 2 Pumilio-family RNA binding repeat SPATA48 PF15073.6 EDN06880.1 - 0.0041 17.4 0.6 0.0041 17.4 0.6 2.6 2 0 0 2 2 2 1 Spermatogenesis-associated protein 48 Chorion_2 PF03964.15 EDN06880.1 - 0.14 13.0 0.1 0.14 13.0 0.1 5.3 5 1 0 6 6 6 0 Chorion family 2 PIN_8 PF18476.1 EDN06880.1 - 1.8 8.3 4.4 1.2 9.0 1.4 2.2 2 0 0 2 2 2 0 PIN like domain DNA_pol_B_palm PF14792.6 EDN06882.1 - 5.1e-35 120.1 0.0 1e-34 119.1 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EDN06882.1 - 1.1e-23 83.1 0.0 2.8e-23 81.9 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EDN06882.1 - 1.7e-19 69.4 0.1 3.3e-19 68.4 0.1 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EDN06882.1 - 4.5e-18 65.4 0.8 1e-17 64.2 0.8 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EDN06882.1 - 0.0032 17.7 0.2 0.011 16.0 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain BRCT PF00533.26 EDN06882.1 - 0.0053 17.1 0.0 0.017 15.5 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDN06882.1 - 0.025 15.0 0.0 0.074 13.5 0.0 1.9 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EDN06882.1 - 0.081 12.9 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain RR_TM4-6 PF06459.12 EDN06882.1 - 0.85 9.4 5.9 1.7 8.4 5.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ATP-synt_10 PF05176.14 EDN06883.1 - 1.4e-87 293.2 0.0 2.5e-87 292.3 0.0 1.4 1 1 1 2 2 2 1 ATP10 protein V-SNARE_C PF12352.8 EDN06884.1 - 1.5e-09 37.9 0.3 1.5e-09 37.9 0.3 2.6 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus LST1 PF05083.13 EDN06884.1 - 0.18 12.1 0.6 0.42 10.9 0.1 1.8 2 0 0 2 2 2 0 LST-1 protein Syntaxin-6_N PF09177.11 EDN06884.1 - 0.64 10.6 8.1 0.18 12.4 3.3 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal GLTSCR1 PF15249.6 EDN06884.1 - 1.6 9.2 6.3 0.8 10.2 1.9 2.1 1 1 1 2 2 2 0 Conserved region of unknown function on GLTSCR protein ALMT PF11744.8 EDN06884.1 - 2.1 7.1 7.1 2.3 6.9 7.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ribosomal_L29 PF00831.23 EDN06885.1 - 6.9e-18 64.4 0.3 6.9e-18 64.4 0.3 2.4 2 1 1 3 3 3 1 Ribosomal L29 protein CorA PF01544.18 EDN06885.1 - 0.12 11.6 1.6 0.15 11.3 1.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Med16 PF11635.8 EDN06886.1 - 5.5e-205 682.6 0.0 6.1e-112 375.0 0.0 2.0 1 1 1 2 2 2 2 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 EDN06886.1 - 0.073 13.4 0.0 18 5.7 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SIR2 PF02146.17 EDN06887.1 - 7.9e-29 100.8 0.0 1.6e-28 99.8 0.0 1.5 1 1 0 1 1 1 1 Sir2 family CBFD_NFYB_HMF PF00808.23 EDN06888.1 - 6.5e-07 29.5 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIIA PF03153.13 EDN06888.1 - 0.013 15.5 9.5 0.021 14.8 9.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Histone PF00125.24 EDN06888.1 - 0.015 15.7 1.0 0.025 14.9 0.1 1.9 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Nop14 PF04147.12 EDN06888.1 - 0.057 11.6 14.2 0.076 11.2 14.2 1.3 1 0 0 1 1 1 0 Nop14-like family CENP-X PF09415.10 EDN06888.1 - 0.7 10.3 0.0 0.7 10.3 0.0 3.0 4 1 0 4 4 4 0 CENP-S associating Centromere protein X DUF740 PF05340.12 EDN06888.1 - 4.3 6.0 8.3 8.2 5.0 8.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF740) GN3L_Grn1 PF08701.11 EDN06889.1 - 7.1e-25 86.9 18.4 7.1e-25 86.9 18.4 1.8 2 0 0 2 2 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EDN06889.1 - 2.1e-17 63.3 0.1 5.6e-14 52.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDN06889.1 - 1.4e-05 25.0 0.0 5.4e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EDN06889.1 - 1.8e-05 24.8 3.6 0.67 10.0 0.0 4.0 3 1 0 4 4 4 2 Dynamin family FeoB_N PF02421.18 EDN06889.1 - 4.9e-05 22.9 0.3 0.00013 21.5 0.1 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EDN06889.1 - 0.0008 19.0 0.0 1.6 8.2 0.0 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 EDN06889.1 - 0.01 14.8 2.2 0.019 13.9 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EDN06889.1 - 0.072 13.6 2.1 0.086 13.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 EDN06889.1 - 0.081 12.5 0.0 0.78 9.3 0.0 2.3 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 EDN06889.1 - 0.14 12.4 0.0 13 6.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EDN06889.1 - 0.48 10.8 0.0 0.48 10.8 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain MAS20 PF02064.15 EDN06889.1 - 3.5 7.8 6.9 2.3 8.3 3.3 2.5 2 1 1 3 3 3 0 MAS20 protein import receptor Pes-10 PF07149.11 EDN06889.1 - 8.3 5.4 9.5 1.9 7.5 6.3 1.4 1 1 0 1 1 1 0 Pes-10 HAD_2 PF13419.6 EDN06890.1 - 7.6e-24 84.8 0.0 9.3e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN06890.1 - 2.1e-13 51.1 0.0 2.6e-09 37.7 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDN06890.1 - 1.4e-07 32.1 0.0 1.9e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN06890.1 - 7.4e-05 22.7 0.3 0.00017 21.6 0.1 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EDN06890.1 - 0.014 15.5 0.1 0.12 12.4 0.0 2.4 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.26 EDN06890.1 - 0.047 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF1106 PF06523.11 EDN06891.1 - 0.011 15.8 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) Papilin_u7 PF16626.5 EDN06891.1 - 0.11 13.1 0.1 0.28 11.8 0.1 1.7 1 0 0 1 1 1 0 Linking region between Kunitz_BPTI and I-set on papilin Homeodomain PF00046.29 EDN06892.1 - 2e-16 59.6 1.8 6.5e-16 57.9 1.8 1.9 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDN06892.1 - 5.6e-05 23.0 1.4 5.6e-05 23.0 1.4 2.4 2 0 0 2 2 2 1 Homeobox KN domain DUF4638 PF15472.6 EDN06892.1 - 0.035 13.8 5.9 0.073 12.8 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PTPRCAP PF15713.5 EDN06892.1 - 0.13 12.5 9.1 0.26 11.5 9.1 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CRC_subunit PF08624.10 EDN06893.1 - 2.8e-52 176.7 0.1 4.6e-52 176.0 0.1 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Sdh_cyt PF01127.22 EDN06896.1 - 2.7e-22 79.1 1.4 3.5e-22 78.7 1.4 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit SLD3 PF08639.10 EDN06897.1 - 5.8e-177 589.7 16.6 5.8e-177 589.7 16.6 1.9 2 0 0 2 2 2 1 DNA replication regulator SLD3 NYD-SP28_assoc PF14775.6 EDN06897.1 - 0.067 13.3 0.4 0.24 11.5 0.4 2.0 1 0 0 1 1 1 0 Sperm tail C-terminal domain S-AdoMet_synt_C PF02773.16 EDN06898.1 - 5.6e-68 227.2 0.9 1.9e-67 225.5 0.1 2.0 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EDN06898.1 - 3.5e-44 149.9 0.0 7.3e-44 148.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EDN06898.1 - 3.9e-44 149.4 0.9 1.2e-43 147.8 0.2 2.0 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EDN06898.1 - 0.062 12.1 0.6 0.66 8.7 0.1 2.1 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) ATP_bind_1 PF03029.17 EDN06899.1 - 7e-77 258.5 0.0 2.2e-76 256.8 0.0 1.7 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EDN06899.1 - 7.8e-05 22.5 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 EDN06899.1 - 0.00028 20.9 0.0 0.0006 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN06899.1 - 0.0005 20.5 0.0 0.00097 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDN06899.1 - 0.0033 17.9 0.0 0.0058 17.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN06899.1 - 0.004 17.4 0.0 0.0071 16.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDN06899.1 - 0.005 17.4 0.0 0.0089 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EDN06899.1 - 0.0074 16.3 0.0 0.0088 16.1 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 EDN06899.1 - 0.0085 15.2 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.22 EDN06899.1 - 0.0085 16.5 0.0 0.018 15.5 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 EDN06899.1 - 0.0086 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDN06899.1 - 0.0097 15.6 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EDN06899.1 - 0.014 15.0 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 EDN06899.1 - 0.016 14.7 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EDN06899.1 - 0.023 14.7 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_31 PF13614.6 EDN06899.1 - 0.026 14.5 0.0 2.5 8.0 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDN06899.1 - 0.026 14.9 0.0 0.082 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EDN06899.1 - 0.033 13.9 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDN06899.1 - 0.034 14.7 0.0 0.12 12.9 0.0 1.8 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 EDN06899.1 - 0.037 14.0 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF463 PF04317.12 EDN06899.1 - 0.039 12.9 0.0 0.06 12.3 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 IstB_IS21 PF01695.17 EDN06899.1 - 0.056 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EDN06899.1 - 0.098 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 KaiC Septin PF00735.18 EDN06899.1 - 0.14 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Septin Sigma54_activat PF00158.26 EDN06899.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EDN06899.1 - 0.15 11.8 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EDN06899.1 - 0.21 11.2 0.2 1 8.9 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ferric_reduct PF01794.19 EDN06900.1 - 1.1e-07 32.0 1.6 1.1e-07 32.0 1.6 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDN06900.1 - 2.7e-07 30.6 0.0 0.035 14.2 0.1 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_6 PF08030.12 EDN06900.1 - 1.6e-06 28.3 0.0 2.7e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF2452 PF10504.9 EDN06900.1 - 0.094 12.2 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) DUF2031 PF09592.10 EDN06901.1 - 0.0021 17.6 0.4 0.0021 17.6 0.4 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF2031) HeH PF12949.7 EDN06901.1 - 0.13 12.0 0.3 1.6 8.5 0.0 2.9 3 0 0 3 3 3 0 HeH/LEM domain Oxysterol_BP PF01237.18 EDN06901.1 - 1.4 7.6 9.2 2.8 6.7 9.2 1.4 1 0 0 1 1 1 0 Oxysterol-binding protein Med26 PF08711.11 EDN06903.1 - 9.5e-10 38.4 0.0 2.1e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Rrn6 PF10214.9 EDN06903.1 - 2.3 6.6 10.5 0.41 9.1 5.0 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Tom5 PF10642.9 EDN06904.1 - 2.6e-21 75.4 0.1 2.8e-21 75.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Nup54 PF13874.6 EDN06905.1 - 1.8e-42 144.8 1.6 1.8e-42 144.8 1.6 2.4 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 EDN06905.1 - 1.7e-09 38.4 86.1 6.3e-07 30.2 39.7 3.4 1 1 2 3 3 3 2 Nucleoporin FG repeat region Nup54_57_C PF18570.1 EDN06905.1 - 1.8e-08 33.8 0.2 3.5e-08 32.9 0.2 1.5 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain Fib_alpha PF08702.10 EDN06905.1 - 0.0054 16.9 2.4 0.018 15.2 2.4 1.8 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Imm-NTF2 PF15655.6 EDN06905.1 - 0.16 12.2 1.3 0.33 11.2 1.3 1.5 1 0 0 1 1 1 0 NTF2 fold immunity protein bMG5 PF17972.1 EDN06905.1 - 0.36 11.2 4.1 0.33 11.3 1.3 2.4 2 1 0 2 2 2 0 Bacterial Alpha-2-macroglobulin MG5 domain AAA PF00004.29 EDN06906.1 - 5.3e-16 59.2 0.0 1.2e-15 58.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EDN06906.1 - 4.4e-12 46.0 0.9 9.9e-12 44.9 0.2 1.9 2 0 0 2 2 1 1 AAA lid domain AAA_16 PF13191.6 EDN06906.1 - 7.5e-12 46.0 0.0 5.8e-11 43.1 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDN06906.1 - 9.3e-10 38.9 0.0 2.1e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDN06906.1 - 0.00034 20.5 0.0 0.00067 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN06906.1 - 0.0021 18.4 0.0 0.0058 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain BAH PF01426.18 EDN06906.1 - 0.0027 17.5 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 BAH domain NACHT PF05729.12 EDN06906.1 - 0.0089 16.0 0.0 0.022 14.7 0.0 1.7 1 1 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 EDN06906.1 - 0.0093 16.1 0.0 0.052 13.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDN06906.1 - 0.016 15.5 0.0 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDN06906.1 - 0.019 14.9 0.0 0.33 10.8 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDN06906.1 - 0.034 14.5 0.0 0.13 12.7 0.0 2.0 2 0 0 2 2 1 0 RNA helicase AAA_30 PF13604.6 EDN06906.1 - 0.064 13.0 0.3 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN06906.1 - 0.076 13.0 0.0 0.27 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_32 PF13654.6 EDN06906.1 - 0.084 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDN06906.1 - 0.091 12.3 0.0 0.5 9.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EDN06906.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_6 PF12774.7 EDN06906.1 - 0.23 10.4 0.0 0.37 9.7 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Alanine_zipper PF11839.8 EDN06906.1 - 0.64 10.4 11.0 0.76 10.2 4.3 2.6 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein WD40 PF00400.32 EDN06907.1 - 2e-44 148.7 12.8 1e-09 38.8 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN06907.1 - 6.6e-06 26.3 0.5 2.5 8.5 0.0 4.9 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN06907.1 - 0.0057 15.4 2.5 3.9 6.0 0.1 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDN06907.1 - 0.02 14.3 0.0 0.065 12.6 0.0 1.8 2 0 0 2 2 2 0 WD40-like domain Ank_2 PF12796.7 EDN06908.1 - 2e-42 143.6 1.5 2.3e-14 53.7 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN06908.1 - 7.6e-34 115.3 4.1 6.7e-11 42.2 0.4 4.7 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN06908.1 - 6.8e-30 99.8 0.2 0.00026 21.2 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 EDN06908.1 - 9.2e-30 102.6 0.9 5e-08 33.3 0.0 5.4 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EDN06908.1 - 1.6e-25 88.3 0.8 0.00013 22.3 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat TMF_TATA_bd PF12325.8 EDN06909.1 - 5.9e-41 139.3 12.0 5.9e-41 139.3 12.0 6.2 3 2 2 5 5 5 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EDN06909.1 - 2.4e-24 85.1 18.1 2.4e-24 85.1 18.1 8.2 6 2 1 8 8 8 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EDN06909.1 - 1e-05 25.9 3.6 1e-05 25.9 3.6 5.6 3 1 2 6 6 6 2 Autophagy protein 16 (ATG16) DUF2443 PF10398.9 EDN06909.1 - 0.016 15.2 4.1 4.9 7.3 0.5 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) Holin_BhlA PF10960.8 EDN06909.1 - 0.12 12.4 2.8 0.76 9.8 2.8 2.6 1 0 0 1 1 1 0 BhlA holin family V-ATPase_H_N PF03224.14 EDN06910.1 - 1.8e-84 283.7 0.0 2.4e-84 283.3 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EDN06910.1 - 3.2e-35 120.8 0.0 1.1e-34 119.0 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H MukF_M PF17192.4 EDN06910.1 - 0.08 12.7 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 MukF middle domain Acetyltransf_1 PF00583.25 EDN06911.1 - 3e-08 33.9 0.0 3.8e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN06911.1 - 2.4e-06 27.5 0.0 3.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN06911.1 - 2.1e-05 24.9 0.0 3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDN06911.1 - 0.0021 18.1 0.0 0.0029 17.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN06911.1 - 0.032 14.2 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein GNAT_acetyltran PF12746.7 EDN06911.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase RHD3 PF05879.12 EDN06912.1 - 0 1053.7 0.0 0 1053.4 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EDN06912.1 - 8.1e-07 28.6 0.1 1.4e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EDN06912.1 - 2.8e-06 27.5 0.0 5.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EDN06912.1 - 0.00031 20.8 0.0 0.00062 19.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EDN06912.1 - 0.0015 18.8 0.0 0.0047 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 EDN06912.1 - 0.11 11.7 0.0 0.27 10.5 0.0 1.7 1 0 0 1 1 1 0 Septin GTP_EFTU PF00009.27 EDN06914.1 - 1.2e-46 158.7 0.0 1.7e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDN06914.1 - 8.3e-24 84.1 0.1 1.9e-23 82.9 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDN06914.1 - 7.7e-18 64.7 1.3 1.9e-17 63.4 1.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EDN06914.1 - 0.0017 18.3 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase cobW PF02492.19 EDN06914.1 - 0.059 13.0 0.0 0.088 12.4 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 EDN06914.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase IF3_C PF00707.22 EDN06915.1 - 3.8e-08 33.2 1.7 6.5e-08 32.4 1.7 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 EDN06915.1 - 3.4e-06 27.2 0.0 7.6e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.6 EDN06915.1 - 2.6e-05 24.0 2.7 2.6e-05 24.0 2.7 1.5 1 1 0 1 1 1 1 Mitochondrial translation initiation factor GDA1_CD39 PF01150.17 EDN06916.1 - 7.6e-103 344.4 0.0 9.6e-103 344.1 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Asn_synthase PF00733.21 EDN06917.1 - 1.9e-68 231.7 0.0 3.3e-68 230.9 0.0 1.3 1 1 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EDN06917.1 - 4.3e-34 117.1 0.0 7.4e-34 116.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDN06917.1 - 2.1e-31 108.9 0.0 5.2e-31 107.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EDN06917.1 - 8.3e-05 22.1 0.0 0.00016 21.2 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein Sod_Fe_N PF00081.22 EDN06918.1 - 3.2e-29 101.2 3.6 6.8e-29 100.2 2.2 2.1 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.18 EDN06918.1 - 3.8e-28 97.7 1.6 2.5e-27 95.0 1.6 2.1 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain DUF4598 PF15370.6 EDN06919.1 - 9.7e-30 103.3 1.5 9.7e-30 103.3 1.5 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) RAP1 PF07218.11 EDN06919.1 - 3.2 5.9 7.7 3.3 5.9 7.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Lin-8 PF03353.15 EDN06919.1 - 4.1 6.9 9.7 4.3 6.8 2.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist IF4E PF01652.18 EDN06920.1 - 1.1e-32 113.0 0.2 1.4e-32 112.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2517 PF10725.9 EDN06920.1 - 0.0018 18.0 0.2 1.5 8.6 0.0 3.1 2 1 1 3 3 3 2 Protein of unknown function (DUF2517) COMPASS-Shg1 PF05205.12 EDN06921.1 - 1.1e-27 96.7 0.1 1.1e-27 96.7 0.1 2.2 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 UPF0767 PF15990.5 EDN06922.1 - 0.036 14.2 0.0 0.044 13.9 0.0 1.1 1 0 0 1 1 1 0 UPF0767 family Cation_efflux PF01545.21 EDN06923.1 - 5.7e-13 49.0 13.1 5.7e-13 49.0 13.1 1.9 2 0 0 2 2 2 1 Cation efflux family Ceramidase PF05875.12 EDN06924.1 - 0.77 9.1 6.2 1.2 8.5 6.2 1.2 1 0 0 1 1 1 0 Ceramidase GCV_H PF01597.19 EDN06925.1 - 2.6e-41 140.3 2.1 3.1e-41 140.1 2.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein ECR1_N PF14382.6 EDN06927.1 - 1.6e-15 56.6 1.0 5.1e-15 55.0 0.1 2.5 2 1 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EDN06927.1 - 9.4e-05 22.7 0.3 0.00019 21.7 0.3 1.5 1 0 0 1 1 1 1 KH domain Oxysterol_BP PF01237.18 EDN06928.1 - 8e-119 396.8 0.0 1.4e-118 395.9 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EDN06928.1 - 8.9e-39 131.7 0.1 2e-38 130.5 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EDN06928.1 - 6e-06 26.7 0.3 4.3e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 PH domain MFS_1 PF07690.16 EDN06929.1 - 1.4e-37 129.4 43.7 2.3e-36 125.5 44.8 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN06929.1 - 3e-19 68.9 19.0 4.3e-19 68.4 19.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDN06929.1 - 7.5e-16 58.0 9.7 7.5e-16 58.0 9.7 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter DUF4748 PF15932.5 EDN06929.1 - 2.9 7.7 6.0 20 5.0 0.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) SH2_2 PF14633.6 EDN06930.1 - 9.6e-77 257.2 0.0 3.1e-76 255.6 0.0 2.0 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 EDN06930.1 - 3.4e-37 127.4 0.9 3.4e-37 127.4 0.9 2.3 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EDN06930.1 - 1.3e-30 105.8 0.0 2.7e-30 104.8 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EDN06930.1 - 2.8e-28 98.6 0.0 8.7e-28 97.0 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 EDN06930.1 - 2.6e-17 63.2 28.2 2.6e-17 63.2 28.2 5.5 4 1 1 6 6 6 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 EDN06930.1 - 1.1e-05 26.2 2.9 0.0002 22.2 2.9 3.0 1 1 0 1 1 1 1 HHH domain HHH_3 PF12836.7 EDN06930.1 - 0.00089 19.5 0.0 0.0024 18.1 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif SH2 PF00017.24 EDN06930.1 - 0.0057 16.7 0.0 0.015 15.4 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Tex_N PF09371.10 EDN06930.1 - 0.015 14.9 1.8 0.27 10.9 0.0 3.2 3 0 0 3 3 3 0 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 EDN06930.1 - 0.11 13.0 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 Tex protein YqgF-like domain Pkinase PF00069.25 EDN06931.1 - 7.5e-60 202.5 0.0 9.4e-60 202.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN06931.1 - 1.2e-31 110.0 0.0 1.6e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN06931.1 - 3.2e-05 22.9 0.0 5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDN06931.1 - 0.002 17.5 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EDN06931.1 - 0.027 13.5 0.0 0.041 12.9 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EDN06931.1 - 0.1 11.5 0.0 0.1 11.5 0.0 1.4 2 0 0 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 EDN06931.1 - 0.16 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family IFRD PF05004.13 EDN06933.1 - 3.9e-89 298.8 0.3 5.4e-89 298.3 0.3 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 EDN06933.1 - 0.0047 17.4 0.0 4.6 7.9 0.0 2.8 2 0 0 2 2 2 2 HEAT-like repeat PG_binding_2 PF08823.11 EDN06933.1 - 0.033 14.5 0.3 0.11 12.8 0.2 2.0 2 0 0 2 2 2 0 Putative peptidoglycan binding domain CoiA PF06054.11 EDN06933.1 - 0.11 11.6 0.0 1.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Competence protein CoiA-like family Arrestin_C PF02752.22 EDN06934.1 - 3.3e-23 82.6 0.0 6.9e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDN06934.1 - 1.1e-05 25.5 0.0 0.0009 19.3 0.0 2.9 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain DDE_1 PF03184.19 EDN06935.1 - 8e-23 81.0 0.0 1.5e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN06935.1 - 1.6e-05 24.7 0.0 0.00079 19.2 0.0 3.1 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06935.1 - 0.0013 18.7 0.0 0.0055 16.7 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN06935.1 - 0.025 14.3 0.5 0.025 14.3 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN06935.1 - 0.041 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) GREB1 PF15782.5 EDN06936.1 - 1.7 5.7 6.8 2 5.4 6.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Plasmodium_Vir PF05795.11 EDN06936.1 - 3 7.2 8.0 5.4 6.3 8.0 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Dicty_REP PF05086.12 EDN06936.1 - 4.4 5.1 22.6 0.37 8.7 7.3 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein PIG-Y PF15159.6 EDN06937.1 - 6.8e-14 52.6 2.7 1.1e-13 51.9 2.7 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF2956 PF11169.8 EDN06937.1 - 0.31 11.3 0.6 0.46 10.7 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) PIG-Y PF15159.6 EDN06938.1 - 5.7e-13 49.6 2.2 1e-12 48.8 2.2 1.4 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y GATase_4 PF13230.6 EDN06939.1 - 1.7e-14 53.3 0.0 6.9e-13 48.1 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 EDN06939.1 - 9.9e-09 35.5 0.0 1.5e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Dynamin_N PF00350.23 EDN06940.1 - 6.3e-45 153.3 0.0 1.2e-44 152.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EDN06940.1 - 1.6e-11 44.0 0.0 8.1e-10 38.4 0.0 2.4 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EDN06940.1 - 1.2e-05 25.3 0.1 0.00013 22.1 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EDN06940.1 - 0.00025 21.5 0.3 0.39 11.1 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 EDN06940.1 - 0.03 13.6 0.2 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_21 PF13304.6 EDN06940.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDN06940.1 - 0.065 12.9 2.2 0.21 11.3 0.1 2.4 3 0 0 3 3 3 0 AAA ATPase domain Roc PF08477.13 EDN06940.1 - 0.19 12.0 0.1 0.63 10.3 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ribosomal_S6 PF01250.17 EDN06941.1 - 8.3e-20 70.9 0.0 1.1e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 Btz PF09405.10 EDN06943.1 - 4e-32 111.2 0.3 1e-31 109.9 0.3 1.7 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding RRM_1 PF00076.22 EDN06944.1 - 1.5e-25 88.8 0.3 1.5e-12 47.1 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN06944.1 - 3.5e-06 27.1 0.0 0.12 12.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EDN06944.1 - 0.00024 21.0 0.0 0.16 12.0 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Spt5_N PF11942.8 EDN06944.1 - 0.13 13.3 5.2 0.39 11.7 5.2 1.8 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Ino80_Iec3 PF14612.6 EDN06945.1 - 4e-74 250.2 0.9 5.2e-74 249.9 0.9 1.1 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling Pkinase PF00069.25 EDN06946.1 - 2.2e-15 56.7 0.0 3.2e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain adh_short_C2 PF13561.6 EDN06946.1 - 1.1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN06946.1 - 1.5e-05 24.6 0.0 2.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Pkinase_Tyr PF07714.17 EDN06946.1 - 0.00033 20.0 0.0 0.00064 19.1 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase N_BRCA1_IG PF16158.5 EDN06947.1 - 1e-30 106.5 0.0 2.9e-30 105.0 0.0 1.8 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EDN06947.1 - 3.7e-19 68.3 59.1 5.1e-07 29.4 6.1 4.5 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 EDN06947.1 - 0.34 11.2 49.4 0.12 12.7 8.6 4.7 4 0 0 4 4 4 0 C1 domain LETM1 PF07766.13 EDN06948.1 - 2e-06 27.4 0.1 0.00065 19.1 0.0 2.3 2 0 0 2 2 2 2 LETM1-like protein DUF3947 PF13135.6 EDN06949.1 - 0.047 13.9 2.4 0.12 12.5 2.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) NTP_transf_2 PF01909.23 EDN06949.1 - 0.15 12.3 0.0 0.59 10.5 0.0 1.9 2 0 0 2 2 2 0 Nucleotidyltransferase domain Med3 PF11593.8 EDN06949.1 - 0.18 11.0 8.3 0.27 10.4 8.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2722 PF10846.8 EDN06949.1 - 0.3 10.0 6.2 0.45 9.4 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Glyco_transf_20 PF00982.21 EDN06950.1 - 1.1e-148 495.9 0.0 1.6e-148 495.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDN06950.1 - 5.7e-75 251.4 0.0 1.2e-74 250.4 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Acetyltransf_1 PF00583.25 EDN06951.1 - 5.1e-05 23.5 0.0 7.7e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN06951.1 - 0.00022 21.6 0.0 0.00041 20.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDN06951.1 - 0.0028 17.6 0.0 0.0044 17.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDN06951.1 - 0.041 14.0 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase K_oxygenase PF13434.6 EDN06952.1 - 3.7e-08 32.9 0.0 6.5e-05 22.2 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EDN06952.1 - 3.1e-07 29.9 0.0 0.00059 19.2 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EDN06952.1 - 1.3e-06 27.2 0.1 6.8e-06 24.8 0.1 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDN06952.1 - 5.2e-05 22.6 0.0 0.028 13.7 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN06952.1 - 5.9e-05 23.2 0.0 0.0002 21.5 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EDN06952.1 - 0.053 13.5 0.0 0.74 9.8 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding MFS_1 PF07690.16 EDN06953.1 - 3.8e-19 68.8 36.5 5.2e-19 68.4 36.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily PP28 PF10252.9 EDN06954.1 - 5.1e-29 100.5 16.9 5.1e-29 100.5 16.9 3.2 2 1 1 3 3 3 2 Casein kinase substrate phosphoprotein PP28 DUF3799 PF12684.7 EDN06956.1 - 0.12 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 PDDEXK-like domain of unknown function (DUF3799) Sec7 PF01369.20 EDN06958.1 - 5.9e-29 101.0 0.0 1.4e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EDN06958.1 - 7.5e-17 61.8 0.0 1.4e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Mto2_bdg PF12808.7 EDN06959.1 - 3.7e-37 126.4 27.3 5e-21 74.7 1.8 10.5 11 1 1 12 12 12 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Cnn_1N PF07989.11 EDN06959.1 - 2.8e-23 81.9 9.8 2.8e-23 81.9 9.8 11.8 10 1 2 13 13 13 2 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 EDN06959.1 - 0.0053 17.0 8.2 0.0053 17.0 8.2 7.6 4 2 4 8 8 8 3 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EDN06959.1 - 0.15 12.1 45.7 0.073 13.1 3.0 7.5 3 1 3 7 7 7 0 Protein of unknown function (DUF1664) DUF5527 PF17665.1 EDN06959.1 - 0.16 11.5 1.7 0.6 9.6 1.7 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Spidroin_N PF16763.5 EDN06959.1 - 7.6 6.6 8.0 20 5.2 3.8 3.0 1 1 1 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term Zn_clus PF00172.18 EDN06961.1 - 2.3e-09 37.2 12.6 4e-09 36.5 12.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exonuc_VII_L PF02601.15 EDN06961.1 - 0.094 12.3 7.1 0.12 11.9 7.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nucleocapsid-N PF11030.8 EDN06961.1 - 2.3 8.2 12.1 4.2 7.3 12.1 1.4 1 0 0 1 1 1 0 Nucleocapsid protein N TFIIA PF03153.13 EDN06961.1 - 4.9 7.0 27.0 5.9 6.8 27.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Aldose_epim PF01263.20 EDN06962.1 - 3.5e-55 187.4 0.0 4.7e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase DUF2664 PF10867.8 EDN06964.1 - 0.052 14.0 0.7 0.063 13.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) DDE_1 PF03184.19 EDN06965.1 - 1.4e-19 70.4 0.1 3.9e-19 69.0 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN06965.1 - 6.3e-11 42.2 0.2 1.8e-09 37.5 0.0 2.8 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain PFL-like PF02901.15 EDN06965.1 - 0.015 14.0 1.0 0.023 13.3 1.0 1.3 1 0 0 1 1 1 0 Pyruvate formate lyase-like DDE_3 PF13358.6 EDN06965.1 - 0.065 13.0 0.1 0.29 10.9 0.1 2.1 2 0 0 2 2 2 0 DDE superfamily endonuclease QRPTase_C PF01729.19 EDN06967.1 - 4.6e-47 159.9 0.2 4.5e-46 156.7 0.2 1.9 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EDN06967.1 - 3.4e-22 78.3 0.0 8.8e-22 77.0 0.0 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Ras PF00071.22 EDN06968.1 - 7.2e-26 90.7 0.0 3.9e-12 46.1 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EDN06968.1 - 0.0062 16.8 0.0 0.021 15.0 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GATA PF00320.27 EDN06969.1 - 7.4e-15 54.3 7.5 2.3e-14 52.7 7.5 1.9 1 0 0 1 1 1 1 GATA zinc finger PAS_9 PF13426.7 EDN06969.1 - 2.7e-12 46.9 0.0 0.00024 21.3 0.0 3.6 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 EDN06969.1 - 4.6e-12 46.0 0.0 7.9e-09 35.7 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EDN06969.1 - 5.1e-05 23.2 0.0 0.074 13.1 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_4 PF08448.10 EDN06969.1 - 0.0013 19.0 0.0 1.3 9.3 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EDN06969.1 - 0.057 13.5 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 PAS domain ERbeta_N PF12497.8 EDN06969.1 - 0.11 12.3 1.7 0.25 11.2 1.2 1.8 1 1 1 2 2 2 0 Estrogen receptor beta DMPK_coil PF08826.10 EDN06969.1 - 0.3 11.2 1.0 0.66 10.1 1.0 1.5 1 0 0 1 1 1 0 DMPK coiled coil domain like Nudix_N_2 PF14803.6 EDN06969.1 - 1 9.3 3.0 2 8.4 3.0 1.5 1 0 0 1 1 1 0 Nudix N-terminal Peptidase_S41 PF03572.18 EDN06971.1 - 3.6e-10 39.7 0.0 7.9e-10 38.6 0.0 1.5 1 1 0 1 1 1 1 Peptidase family S41 Bromodomain PF00439.25 EDN06971.1 - 0.013 15.6 0.3 0.53 10.4 0.0 2.5 2 0 0 2 2 2 0 Bromodomain PLDc PF00614.22 EDN06972.1 - 5.8e-16 57.9 1.5 1.5e-06 28.1 0.1 3.2 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EDN06972.1 - 2.5e-13 50.1 0.0 4e-07 30.0 0.0 3.0 2 1 0 2 2 2 2 PLD-like domain Ribosomal_L27A PF00828.19 EDN06974.1 - 9.6e-21 74.8 0.0 1.3e-20 74.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DEAD_2 PF06733.15 EDN06975.1 - 1.4e-19 70.4 4.8 3.1e-14 53.0 1.1 2.4 1 1 1 2 2 2 2 DEAD_2 Helicase_C_2 PF13307.6 EDN06975.1 - 1.3e-06 28.7 0.0 5.1e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain AAA_22 PF13401.6 EDN06975.1 - 0.23 11.8 0.6 0.5 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain GTP-bdg_M PF16360.5 EDN06975.1 - 0.47 11.1 4.0 0.23 12.1 1.0 1.9 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region DegS PF05384.11 EDN06975.1 - 2.7 7.4 7.7 5.6 6.4 0.1 2.4 2 0 0 2 2 2 0 Sensor protein DegS Sel1 PF08238.12 EDN06976.1 - 4.2e-13 49.5 23.9 8.9e-07 29.4 0.1 7.3 7 1 0 7 7 7 5 Sel1 repeat TPR_1 PF00515.28 EDN06976.1 - 0.014 15.2 0.3 0.053 13.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDN06976.1 - 0.035 14.2 0.2 0.57 10.4 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2267 PF10025.9 EDN06977.1 - 0.0036 17.6 0.7 0.022 15.0 0.5 2.3 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2267) Mito_fiss_reg PF05308.11 EDN06977.1 - 0.0099 16.0 0.4 0.013 15.6 0.4 1.4 1 0 0 1 1 1 1 Mitochondrial fission regulator TMF_TATA_bd PF12325.8 EDN06977.1 - 0.091 13.0 4.3 0.063 13.5 1.9 2.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc24 PF08286.11 EDN06977.1 - 0.1 12.9 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4140 PF13600.6 EDN06977.1 - 0.24 11.9 2.2 0.26 11.7 0.9 1.8 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 EDN06977.1 - 0.38 11.2 3.5 0.44 11.0 1.1 2.2 2 0 0 2 2 2 0 Cell division protein ZapB APG6_N PF17675.1 EDN06977.1 - 0.61 10.6 5.1 2.7 8.5 5.2 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region DivIC PF04977.15 EDN06977.1 - 1.3 8.8 4.3 0.42 10.4 0.3 2.3 2 2 1 3 3 3 0 Septum formation initiator Mto2_bdg PF12808.7 EDN06977.1 - 1.8 9.0 6.9 20 5.6 1.2 3.2 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region zf-CCCH_4 PF18044.1 EDN06978.1 - 0.22 11.4 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger RRM PF10378.9 EDN06978.1 - 0.65 9.8 7.8 6.8 6.5 1.5 3.5 3 0 0 3 3 3 0 Putative RRM domain SRP40_C PF05022.12 EDN06980.1 - 7.2e-17 62.0 0.6 7.2e-17 62.0 0.6 2.2 2 0 0 2 2 2 1 SRP40, C-terminal domain DUF4614 PF15391.6 EDN06980.1 - 0.017 15.1 21.5 0.017 15.1 21.5 4.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4614) RE_Eco29kI PF09517.10 EDN06980.1 - 0.07 12.7 0.1 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 Eco29kI restriction endonuclease RNase_H PF00075.24 EDN06982.1 - 4.3e-12 46.4 0.0 9e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 RNase H Retrotrans_gag PF03732.17 EDN06983.1 - 5.8e-06 26.5 1.2 8.5e-06 26.0 1.2 1.3 1 0 0 1 1 1 1 Retrotransposon gag protein Med15_fungi PF05397.12 EDN06983.1 - 0.036 14.4 0.2 0.043 14.1 0.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 15 RecO_N PF11967.8 EDN06983.1 - 0.13 12.2 0.1 0.34 10.9 0.1 1.7 1 1 0 1 1 1 0 Recombination protein O N terminal FlxA PF14282.6 EDN06985.1 - 0.019 14.9 5.7 0.087 12.8 4.2 2.1 2 0 0 2 2 2 0 FlxA-like protein DUF3375 PF11855.8 EDN06985.1 - 0.032 13.2 7.3 0.043 12.7 4.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) RT_RNaseH PF17917.1 EDN06986.1 - 5.5e-37 126.2 0.0 1.1e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN06986.1 - 2.2e-32 111.1 0.0 5.4e-32 109.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN06986.1 - 7.3e-20 70.8 1.8 1.6e-19 69.8 0.3 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 EDN06986.1 - 1.8e-15 57.1 0.1 1.1e-13 51.2 0.0 2.3 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN06986.1 - 6.7e-13 48.9 0.0 2.5e-12 47.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN06986.1 - 0.0016 18.6 0.0 0.0034 17.6 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVP_2 PF08284.11 EDN06986.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Bromodomain PF00439.25 EDN06989.1 - 1.8e-39 133.7 6.2 4.3e-19 68.4 0.6 2.7 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EDN06989.1 - 2.6e-17 62.8 0.7 7.3e-17 61.4 0.7 1.9 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.14 EDN06989.1 - 0.014 13.7 8.0 0.027 12.8 8.0 1.4 1 0 0 1 1 1 0 CDC45-like protein OTU PF02338.19 EDN06990.1 - 9.1e-08 32.7 0.0 1.8e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease zf-C2HC_2 PF13913.6 EDN06990.1 - 0.053 13.4 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 zinc-finger of a C2HC-type 2-oxoacid_dh PF00198.23 EDN06991.1 - 3.8e-72 242.5 0.0 6.8e-72 241.7 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDN06991.1 - 7.1e-18 64.2 0.7 1.3e-17 63.4 0.7 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDN06991.1 - 0.00057 19.7 0.0 0.0062 16.3 0.0 2.2 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 EDN06991.1 - 0.0016 19.2 0.1 0.36 11.5 0.0 2.4 1 1 1 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 EDN06991.1 - 0.023 14.6 0.3 0.049 13.5 0.3 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_D23 PF16576.5 EDN06991.1 - 0.1 11.8 0.1 0.88 8.7 0.0 2.0 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Ndc1_Nup PF09531.10 EDN06991.1 - 0.15 10.8 1.0 0.21 10.3 1.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MSA-2c PF12238.8 EDN06991.1 - 0.89 9.5 8.6 1.2 9.1 7.9 1.5 2 0 0 2 2 2 0 Merozoite surface antigen 2c Complex1_LYR PF05347.15 EDN06992.1 - 3e-09 36.8 0.8 3e-09 36.8 0.8 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Histone_H2A_C PF16211.5 EDN06993.1 - 4.3e-21 74.4 2.8 7.7e-21 73.5 2.8 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDN06993.1 - 2.2e-17 63.7 0.0 3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDN06993.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDN06994.1 - 6.3e-23 81.6 0.8 7.7e-23 81.3 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDN06994.1 - 4.6e-05 23.6 0.0 0.0001 22.5 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDN06994.1 - 0.00026 21.4 0.0 0.00044 20.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 EDN06994.1 - 0.036 13.7 0.1 0.091 12.4 0.1 1.5 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF1018 PF06252.12 EDN06994.1 - 0.083 13.9 0.7 0.12 13.4 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Peptidase_C54 PF03416.19 EDN06995.1 - 3.5e-61 207.0 0.0 3.1e-48 164.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase family C54 HTH_7 PF02796.15 EDN06996.1 - 1.9e-07 31.0 0.0 5.1e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN06996.1 - 2.7e-06 27.0 0.0 0.00011 21.9 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN06996.1 - 5.8e-06 25.9 0.0 3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_29 PF13551.6 EDN06996.1 - 7.4e-06 25.9 0.0 5.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN06996.1 - 5.5e-05 22.8 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN06996.1 - 0.00018 21.4 0.0 0.00029 20.8 0.0 1.3 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN06996.1 - 0.0071 16.9 0.0 1.2 9.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 EDN06996.1 - 0.036 13.6 0.5 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN06996.1 - 0.047 13.8 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN06996.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN06996.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein FAM176 PF14851.6 EDN06997.1 - 0.088 12.5 1.3 0.12 12.0 1.3 1.2 1 0 0 1 1 1 0 FAM176 family NESP55 PF06390.12 EDN06997.1 - 0.66 9.5 16.9 0.15 11.6 1.7 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) DNA_pol_phi PF04931.13 EDN06997.1 - 0.96 7.5 5.3 1.1 7.3 5.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi Adeno_terminal PF02459.15 EDN06997.1 - 6.5 5.0 6.6 8.3 4.7 6.6 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Trypan_PARP PF05887.11 EDN06997.1 - 8 6.4 24.6 0.36 10.8 2.5 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SCAN PF02023.17 EDN06998.1 - 0.091 12.6 1.7 0.22 11.4 1.7 1.6 1 0 0 1 1 1 0 SCAN domain RVT_1 PF00078.27 EDN06999.1 - 2e-33 115.8 0.0 3.2e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN06999.1 - 7.8e-12 45.6 0.0 1.7e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN06999.1 - 3.5e-11 43.0 0.0 1e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN06999.1 - 0.032 14.6 1.0 0.22 11.9 0.5 2.5 2 0 0 2 2 2 0 ORF 12 gene product N-terminal Nexin_C PF08628.12 EDN07000.1 - 0.0037 17.8 0.6 0.0044 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal R3H PF01424.22 EDN07001.1 - 6.9e-10 38.8 0.0 1.4e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 EDN07001.1 - 3.9e-09 36.3 0.6 8.2e-09 35.2 0.6 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDN07001.1 - 0.006 16.7 0.3 0.006 16.7 0.3 2.7 2 0 0 2 2 2 1 G-patch domain DUF2796 PF10986.8 EDN07001.1 - 1.1 9.2 6.4 2.8 7.9 6.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) DnaJ PF00226.31 EDN07002.1 - 1.4e-23 82.8 0.2 5.9e-23 80.8 0.2 2.1 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 EDN07002.1 - 3.7e-10 39.8 3.4 3.7e-10 39.8 3.4 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDN07002.1 - 1.5e-09 37.9 8.7 2.8e-08 33.9 1.3 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDN07002.1 - 1.4e-06 28.5 3.4 0.003 17.8 0.8 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EDN07002.1 - 0.00044 20.9 5.3 0.15 12.9 0.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN07002.1 - 0.00073 19.9 8.6 0.087 13.3 1.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type SelR PF01641.18 EDN07002.1 - 0.007 16.4 2.7 0.039 14.0 0.3 2.4 2 0 0 2 2 2 1 SelR domain zf-C2H2_3rep PF18868.1 EDN07002.1 - 0.059 14.0 1.9 5.9 7.6 0.0 3.1 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats LIM PF00412.22 EDN07002.1 - 0.34 11.2 2.8 12 6.2 0.2 2.5 2 0 0 2 2 2 0 LIM domain zf-H2C2_2 PF13465.6 EDN07002.1 - 6.6 7.3 5.4 41 4.8 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double domain SPX PF03105.19 EDN07003.1 - 7.7e-49 167.6 0.0 2.3e-48 166.0 0.0 1.7 1 1 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.6 EDN07003.1 - 2.2e-06 27.7 7.9 2.2e-06 27.7 7.9 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EDN07003.1 - 8e-06 25.6 8.0 1.4e-05 24.8 8.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN07003.1 - 2e-05 24.3 10.2 2e-05 24.3 10.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN07003.1 - 0.00014 21.8 8.0 0.00034 20.6 8.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDN07003.1 - 0.00034 20.9 10.2 0.00074 19.8 10.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDN07003.1 - 0.00056 19.8 9.4 0.0013 18.7 9.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDN07003.1 - 0.0014 18.5 9.1 0.003 17.4 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CotJA PF11007.8 EDN07003.1 - 0.0043 16.8 0.2 0.012 15.4 0.0 1.8 2 0 0 2 2 2 1 Spore coat associated protein JA (CotJA) Prok-RING_4 PF14447.6 EDN07003.1 - 0.75 9.7 9.4 3.8 7.4 9.7 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EDN07003.1 - 1.5 8.6 9.2 47 3.7 9.5 2.4 1 1 1 2 2 2 0 P-11 zinc finger zf-RING_4 PF14570.6 EDN07003.1 - 7.1 6.5 8.6 32 4.4 9.0 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain F-box-like PF12937.7 EDN07004.1 - 4.9e-08 32.7 1.0 9.4e-08 31.8 1.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN07004.1 - 3.4e-07 30.0 0.3 5.7e-07 29.3 0.3 1.4 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EDN07004.1 - 0.00048 20.6 0.1 0.00088 19.8 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A YccV-like PF08755.11 EDN07005.1 - 1.1e-21 77.2 0.4 1.9e-21 76.4 0.4 1.4 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like UCH_C PF18031.1 EDN07006.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases DUF1918 PF08940.11 EDN07007.1 - 0.0098 15.5 0.0 4 7.2 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF1918) Nrap_D4 PF17405.2 EDN07008.1 - 3.2e-62 209.7 0.1 5.1e-62 209.0 0.1 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EDN07008.1 - 9.1e-56 188.1 1.5 1.6e-55 187.3 1.5 1.4 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 EDN07008.1 - 1.1e-43 149.0 0.0 2.8e-43 147.8 0.0 1.7 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap PF03813.14 EDN07008.1 - 4.4e-43 146.9 0.0 9.6e-43 145.8 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D6 PF17407.2 EDN07008.1 - 8e-28 97.3 0.0 2.6e-27 95.7 0.0 1.9 2 0 0 2 2 2 1 Nrap protein domain 6 Nrap_D2 PF17403.2 EDN07008.1 - 3.2e-25 88.7 0.3 2.9e-13 49.8 0.0 3.4 2 1 1 3 3 3 3 Nrap protein PAP/OAS-like domain Cys_Met_Meta_PP PF01053.20 EDN07009.1 - 7.9e-32 110.2 0.0 1.1e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDN07009.1 - 0.023 13.9 0.0 0.069 12.3 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class I and II SCAB-ABD PF16711.5 EDN07009.1 - 2.4 8.1 5.4 2.7 7.9 0.3 2.8 3 0 0 3 3 3 0 Actin-binding domain of plant-specific actin-binding protein MRP-L20 PF12824.7 EDN07011.1 - 7e-61 205.2 5.9 8.5e-61 204.9 5.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Peptidase_M20 PF01546.28 EDN07012.1 - 8.5e-27 94.2 0.0 1e-26 93.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDN07012.1 - 9.8e-13 48.0 0.0 1.6e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDN07012.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 SMC_N PF02463.19 EDN07013.1 - 3.6e-21 75.6 10.1 1.7e-20 73.4 10.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EDN07013.1 - 3.6e-10 40.1 13.6 3.6e-10 40.1 13.6 3.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EDN07013.1 - 1.8e-09 38.4 30.6 1.8e-09 38.4 30.6 5.1 2 2 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EDN07013.1 - 1e-08 35.4 12.1 2.3e-06 27.6 0.6 2.9 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDN07013.1 - 0.00059 19.5 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain HOOK PF05622.12 EDN07013.1 - 0.0022 16.2 25.3 0.0022 16.2 25.3 4.0 2 2 2 4 4 4 1 HOOK protein Tropomyosin_1 PF12718.7 EDN07013.1 - 0.01 16.0 2.1 0.01 16.0 2.1 6.5 3 2 2 5 5 5 0 Tropomyosin like ABC_tran PF00005.27 EDN07013.1 - 0.085 13.4 0.1 0.085 13.4 0.1 5.1 4 2 0 4 4 4 0 ABC transporter DUF4453 PF14627.6 EDN07016.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) WD40 PF00400.32 EDN07018.1 - 3.2e-05 24.6 3.2 0.12 13.3 0.0 5.0 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07018.1 - 0.00039 20.7 0.2 1.1 9.6 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DIOX_N PF14226.6 EDN07019.1 - 1.3e-31 109.8 0.2 3.6e-29 101.9 0.1 3.0 2 1 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EDN07019.1 - 3.8e-10 40.2 0.0 7.2e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GxGYxYP_C PF14323.6 EDN07019.1 - 0.092 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain MFS_1 PF07690.16 EDN07020.1 - 1.4e-40 139.3 42.7 1.2e-39 136.2 42.7 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 EDN07020.1 - 1.2e-06 27.6 2.9 0.00013 20.8 0.1 2.4 2 0 0 2 2 2 2 LacY proton/sugar symporter DUF1414 PF07208.11 EDN07020.1 - 0.09 12.8 0.0 1.5 8.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1414) DNA_primase_S PF01896.19 EDN07021.1 - 6.8e-62 208.6 0.0 9.7e-62 208.1 0.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit MAM33 PF02330.16 EDN07022.1 - 3.5e-73 246.0 6.1 7.3e-73 245.0 6.1 1.5 1 1 0 1 1 1 1 Mitochondrial glycoprotein Tma16 PF11176.8 EDN07023.1 - 3.2e-51 173.1 0.2 4e-51 172.7 0.2 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 MmgE_PrpD PF03972.14 EDN07023.1 - 0.049 12.2 0.0 0.059 11.9 0.0 1.1 1 0 0 1 1 1 0 MmgE/PrpD family DASH_Spc34 PF08657.10 EDN07023.1 - 0.11 12.3 0.2 0.15 11.9 0.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 SlyX PF04102.12 EDN07023.1 - 0.16 12.6 2.9 1.5 9.5 0.6 2.3 2 0 0 2 2 2 0 SlyX XPG_I PF00867.18 EDN07024.1 - 6.6e-24 84.1 0.1 1.3e-23 83.1 0.1 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EDN07024.1 - 3.1e-23 82.2 0.0 8.5e-23 80.8 0.0 1.8 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I_2 PF12813.7 EDN07024.1 - 0.0017 17.9 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 EDN07024.1 - 0.033 14.3 0.0 0.095 12.9 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Fig1 PF12351.8 EDN07025.1 - 1.7e-56 191.2 6.1 1.7e-56 191.2 6.1 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EDN07025.1 - 0.001 18.7 12.3 0.0019 17.9 12.3 1.5 1 1 0 1 1 1 1 SUR7/PalI family DUF2207 PF09972.9 EDN07025.1 - 0.094 11.5 0.0 0.094 11.5 0.0 2.9 1 1 2 3 3 3 0 Predicted membrane protein (DUF2207) DUF898 PF05987.13 EDN07025.1 - 0.96 8.4 15.5 0.028 13.5 8.9 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) HAD_SAK_1 PF10307.9 EDN07026.1 - 6.9e-80 267.6 0.0 1.1e-79 267.0 0.0 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins zf-RING_2 PF13639.6 EDN07027.1 - 3.5e-09 36.9 5.6 6.3e-09 36.0 5.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN07027.1 - 1.1e-06 28.4 3.3 1.6e-06 27.8 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN07027.1 - 1.8e-06 27.7 4.7 3e-06 27.0 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN07027.1 - 2.2e-06 27.4 6.4 3.5e-06 26.7 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDN07027.1 - 1.3e-05 25.4 5.1 3.9e-05 23.9 5.1 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EDN07027.1 - 0.00087 19.1 4.5 0.0016 18.2 4.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Peptidase_C41 PF05417.11 EDN07027.1 - 0.088 12.6 0.2 0.16 11.8 0.2 1.3 1 0 0 1 1 1 0 Hepatitis E cysteine protease zf-RING_11 PF17123.5 EDN07027.1 - 0.12 12.2 2.3 0.25 11.1 2.3 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EDN07027.1 - 0.31 11.1 2.3 0.72 9.9 2.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EDN07027.1 - 1.2 9.1 3.3 2.4 8.2 3.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Drc1-Sld2 PF11719.8 EDN07028.1 - 1.4e-157 525.9 11.8 1.7e-157 525.6 11.8 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein UPF0182 PF03699.13 EDN07031.1 - 0.022 12.9 0.0 0.036 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Rnf-Nqr PF02508.14 EDN07031.1 - 0.22 11.5 2.5 0.41 10.6 2.5 1.4 1 0 0 1 1 1 0 Rnf-Nqr subunit, membrane protein DEAD PF00270.29 EDN07032.1 - 5.7e-09 36.0 0.0 1.8e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN07032.1 - 0.0002 21.4 0.0 0.00056 20.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Integrase_H2C2 PF17921.1 EDN07032.1 - 0.00087 19.4 0.2 0.0022 18.0 0.2 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN07033.1 - 6.7e-05 23.1 0.0 0.00012 22.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 EDN07034.1 - 1.4e-33 116.3 0.0 5.6e-33 114.3 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN07034.1 - 1e-11 44.7 0.0 2.8e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN07034.1 - 1.1e-11 45.1 0.0 2.7e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN07034.1 - 0.069 13.6 0.8 0.34 11.4 0.5 2.3 2 0 0 2 2 2 0 ORF 12 gene product N-terminal Acetyltransf_1 PF00583.25 EDN07035.1 - 4.1e-09 36.7 0.0 5.9e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN07035.1 - 2.3e-06 27.5 0.0 4.3e-06 26.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN07035.1 - 0.00016 22.1 0.1 0.00029 21.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN07035.1 - 0.002 18.0 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein CENP-Q PF13094.6 EDN07036.1 - 0.0054 16.9 1.8 0.0054 16.9 1.8 2.3 2 1 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit T2SSF PF00482.23 EDN07036.1 - 0.11 12.5 0.1 0.34 10.8 0.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F FUSC PF04632.12 EDN07036.1 - 0.15 10.5 2.3 0.27 9.7 2.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family HET PF06985.11 EDN07037.1 - 0.00054 20.3 0.0 0.00075 19.9 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) PCI PF01399.27 EDN07038.1 - 1.5e-10 41.5 0.8 6.1e-09 36.3 0.1 3.2 2 0 0 2 2 2 1 PCI domain G-gamma PF00631.22 EDN07039.1 - 3.7e-24 84.5 0.0 4e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 GGL domain SF1-HH PF16275.5 EDN07039.1 - 0.14 12.5 0.2 0.19 12.1 0.2 1.2 1 1 0 1 1 1 0 Splicing factor 1 helix-hairpin domain Rdx PF10262.9 EDN07040.1 - 7.9e-32 109.3 0.0 1.2e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Rdx family PDEase_I PF00233.19 EDN07041.1 - 4.5e-58 196.8 0.0 8.3e-58 195.9 0.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DEAD PF00270.29 EDN07042.1 - 9.5e-13 48.3 0.0 2.3e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN07042.1 - 2.9e-08 34.0 0.0 1e-07 32.2 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07042.1 - 0.0013 18.8 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_5 PF14520.6 EDN07042.1 - 0.01 16.4 0.0 0.034 14.8 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF4332 PF14229.6 EDN07042.1 - 0.045 14.0 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Sigma70_r4 PF04545.16 EDN07042.1 - 0.1 12.2 0.2 1.5 8.4 0.0 2.9 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_45 PF14947.6 EDN07042.1 - 0.18 11.8 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix BAH PF01426.18 EDN07044.1 - 2.3e-17 63.0 0.0 3.9e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H_2 PF13832.6 EDN07045.1 - 3.3e-22 78.7 0.1 3.3e-22 78.7 0.1 3.3 4 0 0 4 4 4 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDN07045.1 - 7.9e-20 70.9 11.4 2e-19 69.6 0.4 3.5 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.6 EDN07045.1 - 9.5e-08 31.5 4.9 9.5e-08 31.5 4.9 4.0 5 0 0 5 5 5 1 PHD-finger PHD PF00628.29 EDN07045.1 - 5.2e-06 26.3 8.3 5.2e-06 26.3 8.3 4.7 5 0 0 5 5 5 2 PHD-finger C1_2 PF03107.16 EDN07045.1 - 0.045 14.1 24.8 0.13 12.6 0.4 4.7 4 0 0 4 4 4 0 C1 domain Myb_DNA-binding PF00249.31 EDN07045.1 - 0.083 13.1 0.0 0.31 11.3 0.0 2.0 1 0 0 1 1 1 0 Myb-like DNA-binding domain GATase_2 PF00310.21 EDN07046.1 - 0.16 10.6 0.0 0.2 10.4 0.0 1.0 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Rieske PF00355.26 EDN07048.1 - 0.0037 17.2 0.1 0.007 16.3 0.1 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain COE1_DBD PF16422.5 EDN07048.1 - 0.035 13.5 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Transcription factor COE1 DNA-binding domain tRNA-synt_1f PF01921.18 EDN07048.1 - 0.19 10.6 0.0 0.79 8.6 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (K) DDE_1 PF03184.19 EDN07049.1 - 4.7e-18 65.4 0.0 9.4e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07049.1 - 5.9e-14 51.8 0.6 1.5e-13 50.5 0.1 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN07049.1 - 0.017 14.8 0.1 0.042 13.6 0.1 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease Pkinase PF00069.25 EDN07050.1 - 1.4e-08 34.4 0.0 3.4e-08 33.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN07050.1 - 2.1e-07 31.1 0.0 1.2e-06 28.6 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN07050.1 - 0.00024 20.5 0.0 0.00037 19.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EDN07050.1 - 0.0051 16.1 0.0 0.0074 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EDN07050.1 - 0.079 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase CLTH PF10607.9 EDN07053.1 - 4e-35 120.9 0.0 5.7e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DDE_Tnp_1_7 PF13843.6 EDN07054.1 - 2.2e-55 188.4 0.0 3.7e-54 184.3 0.0 2.0 1 1 0 1 1 1 1 Transposase IS4 APH PF01636.23 EDN07055.1 - 2.3e-12 47.3 0.0 4.8e-12 46.3 0.0 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EDN07055.1 - 0.00058 18.8 0.0 0.0012 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EDN07055.1 - 0.0051 16.2 0.0 0.0087 15.4 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EDN07055.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EDN07055.1 - 0.073 12.4 0.0 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PG_binding_1 PF01471.18 EDN07057.1 - 0.006 16.8 0.0 0.69 10.2 0.0 2.9 3 0 0 3 3 3 1 Putative peptidoglycan binding domain TRAF_BIRC3_bd PF16673.5 EDN07057.1 - 0.09 12.6 0.6 4 7.3 0.1 2.6 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain zf-Tim10_DDP PF02953.15 EDN07058.1 - 5e-22 77.3 1.8 7.7e-22 76.7 1.8 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger tRNA-synt_2 PF00152.20 EDN07059.1 - 1.9e-41 142.2 0.0 2.1e-31 109.2 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDN07059.1 - 7.1e-08 32.3 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain BTB PF00651.31 EDN07060.1 - 2.9e-06 27.5 0.0 1.4e-05 25.3 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.15 EDN07060.1 - 0.0049 17.0 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Mic1 PF07035.12 EDN07060.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Colon cancer-associated protein Mic1-like DUF433 PF04255.14 EDN07061.1 - 0.052 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF433) TPR_2 PF07719.17 EDN07061.1 - 0.053 13.6 0.3 0.14 12.3 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDN07061.1 - 0.12 12.2 0.8 0.3 11.0 0.8 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Ribosomal_L18A PF01775.17 EDN07062.1 - 1.5e-54 183.3 0.8 1.9e-54 182.9 0.8 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF2887 PF11103.8 EDN07062.1 - 0.065 13.2 0.0 0.078 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) NAD_binding_1 PF00175.21 EDN07064.1 - 6.6e-32 110.4 0.0 1.4e-31 109.4 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDN07064.1 - 2.7e-20 72.6 0.0 5.4e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDN07064.1 - 1.6e-09 38.1 0.0 1.9e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Phosphonate-bd PF12974.7 EDN07064.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein HMG_box PF00505.19 EDN07065.1 - 5e-11 42.8 3.8 5e-11 42.8 3.8 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDN07065.1 - 1.8e-05 25.3 2.5 1.8e-05 25.3 2.5 2.2 2 0 0 2 2 2 1 HMG-box domain DNA_pol_phi PF04931.13 EDN07065.1 - 0.83 7.7 8.3 1.1 7.2 8.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EDN07065.1 - 2 6.6 15.6 2.9 6.1 15.6 1.2 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 EDN07065.1 - 4.2 7.8 12.4 8.7 6.8 12.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Herpes_DNAp_acc PF04929.12 EDN07065.1 - 4.4 6.2 13.5 8.1 5.3 13.5 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor TRAP_alpha PF03896.16 EDN07065.1 - 7.9 5.6 6.7 16 4.6 6.7 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Amidohydro_1 PF01979.20 EDN07066.1 - 2.1e-76 257.5 1.3 2.7e-75 253.8 0.6 2.1 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.20 EDN07066.1 - 3.5e-54 182.3 1.8 8.3e-54 181.1 1.8 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EDN07066.1 - 1.3e-41 140.6 0.1 1.5e-40 137.1 0.0 2.3 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 EDN07066.1 - 8.1e-39 131.9 0.1 2.5e-38 130.4 0.1 1.9 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EDN07066.1 - 3.2e-07 30.2 0.1 0.0007 19.2 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase family Lactamase_B_2 PF12706.7 EDN07067.1 - 0.00011 21.8 0.0 0.00061 19.4 0.0 2.1 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDN07067.1 - 0.086 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily NPR2 PF06218.11 EDN07070.1 - 2.5e-131 438.5 0.0 1.7e-130 435.8 0.0 1.9 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Ada3 PF10198.9 EDN07071.1 - 6.9e-51 171.8 2.1 8.4e-51 171.6 0.1 2.1 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 zf-RING_2 PF13639.6 EDN07072.1 - 7.3e-12 45.4 6.0 1.3e-11 44.6 6.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDN07072.1 - 1.8e-08 33.9 1.4 4.1e-08 32.8 1.4 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDN07072.1 - 3e-08 33.4 5.5 5.7e-08 32.5 5.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN07072.1 - 1.8e-06 27.9 2.2 1.8e-06 27.9 2.2 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDN07072.1 - 4.5e-06 26.5 3.4 8.4e-06 25.7 3.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDN07072.1 - 1e-05 25.3 4.1 1.8e-05 24.5 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN07072.1 - 0.00022 21.0 2.3 0.0004 20.2 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDN07072.1 - 0.00048 20.4 8.0 0.0018 18.5 8.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDN07072.1 - 0.002 18.1 2.3 0.0046 17.0 2.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDN07072.1 - 0.0055 16.5 9.6 0.1 12.5 9.7 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 LapA_dom PF06305.11 EDN07072.1 - 0.017 14.9 1.6 0.034 14.0 1.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain zf-RING_4 PF14570.6 EDN07072.1 - 0.039 13.7 4.5 0.071 12.9 4.5 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EDN07072.1 - 0.093 12.6 4.0 0.23 11.3 4.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 EDN07072.1 - 0.16 11.6 2.2 0.37 10.4 2.2 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EDN07072.1 - 0.57 10.4 5.8 1.8 8.8 5.8 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 EDN07072.1 - 1 9.7 4.9 0.15 12.4 0.9 1.6 2 0 0 2 2 1 0 RING-like domain PHD PF00628.29 EDN07072.1 - 1.4 8.9 3.5 2.7 8.0 3.5 1.5 1 0 0 1 1 1 0 PHD-finger zf-P11 PF03854.14 EDN07072.1 - 3.7 7.3 7.6 0.37 10.5 2.5 1.9 2 0 0 2 2 2 0 P-11 zinc finger FRG1 PF06229.12 EDN07073.1 - 4e-57 193.0 0.1 5.7e-57 192.5 0.1 1.2 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 EDN07073.1 - 0.023 14.9 0.0 0.094 12.9 0.0 2.0 2 1 0 2 2 2 0 Fascin domain ADH_N PF08240.12 EDN07074.1 - 4.6e-26 90.8 1.5 1.7e-25 89.0 1.2 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN07074.1 - 1.9e-14 53.7 0.0 3.7e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDN07074.1 - 5.3e-11 42.4 0.0 7.8e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EDN07074.1 - 1e-06 29.8 0.0 1.7e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 EDN07074.1 - 0.0078 16.5 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EDN07074.1 - 0.02 15.3 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EDN07074.1 - 0.032 13.5 0.6 0.046 13.0 0.6 1.2 1 0 0 1 1 1 0 FAD binding domain NADH_4Fe-4S PF10589.9 EDN07074.1 - 0.035 14.2 0.5 0.11 12.5 0.5 1.9 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region HECT PF00632.25 EDN07075.1 - 6.8e-77 259.0 0.0 8.9e-77 258.6 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4360 PF14273.6 EDN07079.1 - 2.6e-70 235.9 0.2 3e-70 235.7 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Ribosomal_L15e PF00827.17 EDN07080.1 - 1.1e-89 299.3 9.9 1.3e-89 299.0 9.9 1.0 1 0 0 1 1 1 1 Ribosomal L15 NOA36 PF06524.12 EDN07081.1 - 0.66 9.2 10.3 1.4 8.2 10.3 1.5 1 0 0 1 1 1 0 NOA36 protein Importin_rep_4 PF18808.1 EDN07081.1 - 1 9.7 6.5 2.8 8.3 6.5 1.7 1 0 0 1 1 1 0 Importin repeat Cwf_Cwc_15 PF04889.12 EDN07081.1 - 1.5 8.5 21.8 0.057 13.2 15.1 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PSP1 PF04468.12 EDN07082.1 - 8.5e-29 99.7 3.0 1.4e-28 99.0 3.0 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region NifU PF01106.17 EDN07085.1 - 3.4e-28 97.6 0.1 5.6e-28 96.9 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 EDN07085.1 - 5.5e-28 96.9 0.0 1.9e-27 95.1 0.0 1.9 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal RasGEF PF00617.19 EDN07086.1 - 1.3e-45 155.8 0.1 2.4e-45 154.9 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDN07086.1 - 3.3e-15 56.2 0.0 7.7e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Complex1_LYR_2 PF13233.6 EDN07087.1 - 2.3e-22 79.5 1.7 3.1e-22 79.1 1.7 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Retrotran_gag_2 PF14223.6 EDN07087.1 - 0.042 13.5 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Cyclin_N PF00134.23 EDN07088.1 - 3.4e-12 46.2 0.0 6.5e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDN07088.1 - 2.8e-05 24.5 0.0 4.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Cyclin Ras PF00071.22 EDN07090.1 - 6.1e-09 35.7 0.0 4.2e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EDN07090.1 - 1.2e-07 32.0 0.0 2.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ThiI PF02568.14 EDN07090.1 - 0.021 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) AAA_24 PF13479.6 EDN07090.1 - 0.19 11.4 0.1 4.1 7.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain ODC_AZ PF02100.17 EDN07092.1 - 8.6e-23 80.5 0.0 1.4e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Yippee-Mis18 PF03226.14 EDN07093.1 - 1.5e-26 92.6 0.1 2.3e-26 92.1 0.1 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EDN07093.1 - 0.0016 18.7 2.3 0.02 15.1 0.1 2.2 2 0 0 2 2 2 1 C-terminal domain of RIG-I Transp_Tc5_C PF04236.15 EDN07093.1 - 0.13 12.7 0.3 4.1 7.8 0.2 2.6 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain SCNM1_acidic PF15805.5 EDN07093.1 - 1.5 8.6 6.3 3.1 7.6 6.3 1.5 1 0 0 1 1 1 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 SHNi-TPR PF10516.9 EDN07094.1 - 1.9e-15 56.0 1.0 1.9e-15 56.0 1.0 3.0 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.6 EDN07094.1 - 9.6e-05 22.6 6.6 0.021 15.1 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat PCAF_N PF06466.11 EDN07094.1 - 0.0077 15.8 0.3 0.013 15.1 0.3 1.3 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain DUF4297 PF14130.6 EDN07094.1 - 0.053 13.6 3.3 0.14 12.2 3.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4297) TPR_7 PF13176.6 EDN07094.1 - 0.12 12.5 3.4 5.9 7.2 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDN07094.1 - 0.13 12.2 5.0 1.3 8.9 0.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07094.1 - 0.38 11.4 4.9 1.6 9.4 0.9 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDN07094.1 - 0.47 10.4 3.4 66 3.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EDN07094.1 - 0.6 10.2 5.6 1.8 8.6 0.4 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07094.1 - 0.62 10.4 9.3 3.8 8.0 0.8 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDN07094.1 - 0.74 10.1 14.9 0.84 9.9 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF1664 PF07889.12 EDN07094.1 - 1.5 8.9 6.2 1.4 8.9 2.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MIT PF04212.18 EDN07094.1 - 1.5 8.9 8.8 0.33 11.0 1.5 3.1 3 0 0 3 3 2 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EDN07094.1 - 3.2 8.8 8.5 11 7.2 0.2 3.3 4 0 0 4 4 2 0 Tetratricopeptide repeat TMPIT PF07851.13 EDN07094.1 - 3.6 6.7 10.1 1.9 7.6 5.1 2.2 1 1 1 2 2 2 0 TMPIT-like protein TPR_11 PF13414.6 EDN07094.1 - 5 6.9 7.7 12 5.7 1.1 3.5 4 0 0 4 4 4 0 TPR repeat TBCA PF02970.16 EDN07094.1 - 9.7 6.6 13.8 38 4.7 1.5 3.5 2 1 0 2 2 2 0 Tubulin binding cofactor A DNA_pol_E_B PF04042.16 EDN07095.1 - 1.9e-50 171.2 0.1 2.5e-50 170.7 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Med14 PF08638.11 EDN07096.1 - 9.7e-65 217.6 0.1 1.9e-64 216.6 0.1 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 Fer4_24 PF18109.1 EDN07096.1 - 0.57 10.5 2.7 0.36 11.1 0.4 1.8 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain RVT_2 PF07727.14 EDN07098.1 - 2.8e-43 148.3 0.0 4.1e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN07098.1 - 4.9e-12 46.1 0.0 1.3e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 EDN07098.1 - 0.00038 20.4 2.5 0.00077 19.4 2.5 1.5 1 0 0 1 1 1 1 Zinc knuckle gag_pre-integrs PF13976.6 EDN07098.1 - 0.0026 17.6 0.4 0.0064 16.3 0.0 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN07098.1 - 0.01 15.5 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type U3_snoRNA_assoc PF08297.11 EDN07098.1 - 0.44 11.3 6.8 2.2 9.1 6.8 2.3 1 0 0 1 1 1 0 U3 snoRNA associated CobT PF06213.12 EDN07098.1 - 0.46 9.8 3.8 0.94 8.8 3.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Thioredoxin PF00085.20 EDN07099.1 - 3.3e-62 206.9 7.4 4.5e-31 106.9 0.1 4.3 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 EDN07099.1 - 2e-44 151.7 1.0 1.4e-32 113.1 0.2 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.17 EDN07099.1 - 4.3e-09 35.9 0.4 9.7e-09 34.7 0.4 1.5 1 0 0 1 1 1 1 Calsequestrin OST3_OST6 PF04756.13 EDN07099.1 - 1.7e-08 34.2 0.5 0.0015 18.0 0.0 3.1 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDN07099.1 - 4.1e-08 33.6 0.5 0.0058 17.1 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EDN07099.1 - 8.5e-08 32.3 0.0 0.028 14.6 0.0 3.0 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EDN07099.1 - 6.9e-07 29.2 0.1 0.0097 15.8 0.0 2.6 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 EDN07099.1 - 8.2e-07 29.3 0.2 0.095 13.0 0.0 4.5 3 1 1 4 4 4 2 Thioredoxin-like ERp29_N PF07912.13 EDN07099.1 - 1.3e-05 25.4 0.1 0.71 10.0 0.0 3.4 3 0 0 3 3 3 2 ERp29, N-terminal domain Redoxin PF08534.10 EDN07099.1 - 0.00082 19.1 0.6 0.52 10.0 0.0 3.1 3 0 0 3 3 3 1 Redoxin Thioredoxin_4 PF13462.6 EDN07099.1 - 0.029 14.5 0.7 4.5 7.4 0.0 3.1 2 1 1 3 3 3 0 Thioredoxin TraF PF13728.6 EDN07099.1 - 8 6.2 8.0 3.1 7.6 0.1 3.2 3 1 0 3 3 3 0 F plasmid transfer operon protein RVT_1 PF00078.27 EDN07100.1 - 1.8e-40 138.8 0.0 2.8e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN07100.1 - 1.9e-13 50.3 0.0 5.8e-13 48.7 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN07100.1 - 0.00028 20.5 0.1 0.00049 19.7 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CHASE3 PF05227.13 EDN07100.1 - 3 7.7 8.1 1.2 9.1 4.6 2.2 2 0 0 2 2 2 0 CHASE3 domain zf-CCHC PF00098.23 EDN07100.1 - 4 7.7 8.7 1.6 9.0 4.8 2.4 2 0 0 2 2 2 0 Zinc knuckle gag_pre-integrs PF13976.6 EDN07101.1 - 1.5e-05 24.7 0.3 2.4e-05 24.1 0.3 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_1 PF00078.27 EDN07103.1 - 3.7e-34 118.2 0.0 5.2e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UDG PF03167.19 EDN07104.1 - 2.5e-22 79.5 0.2 4e-22 78.9 0.2 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Sld3_N PF18523.1 EDN07104.1 - 0.078 13.1 0.1 0.4 10.8 0.1 2.0 1 1 0 1 1 1 0 Sld3 N-terminal domain PAC2 PF09754.9 EDN07104.1 - 0.15 12.0 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 PAC2 family Actin PF00022.19 EDN07105.1 - 1.5e-115 386.1 0.0 1.9e-115 385.8 0.0 1.0 1 0 0 1 1 1 1 Actin Hep_59 PF07052.11 EDN07106.1 - 4.2e-18 66.0 0.1 4.2e-18 66.0 0.1 3.1 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 TRP PF06011.12 EDN07107.1 - 5.5e-149 496.5 17.3 7.1e-149 496.1 17.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDN07107.1 - 3.1e-33 115.1 0.3 4.7e-33 114.5 0.3 1.3 1 0 0 1 1 1 1 ML-like domain TRP PF06011.12 EDN07108.1 - 1.1e-36 126.5 1.3 1.5e-36 126.1 1.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDN07108.1 - 6.2e-24 84.9 0.0 1e-23 84.3 0.0 1.3 1 0 0 1 1 1 1 ML-like domain RRM_1 PF00076.22 EDN07109.1 - 5.9e-26 90.1 0.0 5.2e-16 58.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN07109.1 - 2e-11 43.9 0.1 2.4e-05 24.4 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 EDN07109.1 - 0.00058 19.9 0.1 0.18 11.9 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 EDN07109.1 - 0.0049 16.8 0.0 3 7.9 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif EF-hand_12 PF17901.1 EDN07109.1 - 0.011 16.1 0.1 0.38 11.3 0.0 2.1 2 0 0 2 2 2 0 EF-hand fold domain TMEM156 PF15106.6 EDN07109.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 TMEM156 protein family RabGAP-TBC PF00566.18 EDN07110.1 - 1.4e-39 136.0 0.0 8.4e-39 133.5 0.0 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RrnaAD PF00398.20 EDN07111.1 - 9.3e-26 90.5 0.1 1.2e-25 90.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EDN07111.1 - 4.5e-08 33.7 0.0 9.6e-08 32.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN07111.1 - 1.3e-06 28.9 0.0 2.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDN07111.1 - 1.4e-05 24.6 0.0 1.9e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDN07111.1 - 1.8e-05 25.4 0.0 5.5e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EDN07111.1 - 2.6e-05 24.1 0.0 2.9e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EDN07111.1 - 5.6e-05 23.0 0.0 5.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDN07111.1 - 0.0001 21.9 0.1 0.00015 21.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EDN07111.1 - 0.0026 17.3 0.0 0.0057 16.1 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EDN07111.1 - 0.0056 16.0 0.0 0.0065 15.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EDN07111.1 - 0.0063 16.3 0.0 0.011 15.5 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 EDN07111.1 - 0.0068 15.7 0.0 0.0079 15.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_28 PF02636.17 EDN07111.1 - 0.014 15.0 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Met_10 PF02475.16 EDN07111.1 - 0.015 15.1 0.0 0.018 14.8 0.0 1.4 1 1 0 1 1 1 0 Met-10+ like-protein Methyltransf_18 PF12847.7 EDN07111.1 - 0.016 15.1 0.1 0.035 14.0 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase domain PrmA PF06325.13 EDN07111.1 - 0.018 14.4 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.12 EDN07111.1 - 0.023 13.8 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase DOT1 PF08123.13 EDN07111.1 - 0.063 12.8 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 NodS PF05401.11 EDN07111.1 - 0.09 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 EDN07111.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PRP1_N PF06424.12 EDN07112.1 - 2e-53 180.8 6.7 2e-53 180.8 6.7 1.9 2 0 0 2 2 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EDN07112.1 - 8.6e-25 85.3 29.1 7.4e-05 23.3 0.1 12.5 4 3 9 13 13 13 6 Tetratricopeptide repeat TPR_19 PF14559.6 EDN07112.1 - 8.2e-24 83.9 11.3 1.3e-06 28.8 0.3 9.2 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDN07112.1 - 1.5e-10 40.3 14.2 0.018 15.1 0.0 8.2 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07112.1 - 2.1e-10 39.9 0.3 0.35 11.2 0.0 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDN07112.1 - 2.6e-09 36.6 0.2 0.73 9.6 0.0 6.6 6 1 1 7 7 7 2 TPR repeat TPR_1 PF00515.28 EDN07112.1 - 6.1e-08 32.2 1.1 0.032 14.1 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07112.1 - 1.6e-06 28.7 22.4 0.0013 19.3 0.1 7.4 6 2 3 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDN07112.1 - 2.4e-06 27.5 8.2 2.1 8.9 0.2 8.3 8 1 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN07112.1 - 0.00033 20.8 2.0 1.8 8.8 0.1 4.4 3 1 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDN07112.1 - 0.0024 18.1 4.8 0.15 12.3 0.3 5.7 6 1 1 7 7 6 2 Tetratricopeptide repeat Suf PF05843.14 EDN07112.1 - 0.0086 16.1 1.7 4.5 7.2 0.1 3.7 3 1 0 3 3 3 1 Suppressor of forked protein (Suf) ZNRF_3_ecto PF18212.1 EDN07112.1 - 0.017 15.1 0.1 20 5.2 0.0 4.3 4 0 0 4 4 4 0 ZNRF-3 Ectodomain TPR_6 PF13174.6 EDN07112.1 - 0.029 15.0 13.0 26 5.7 0.1 7.9 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDN07112.1 - 0.041 14.0 6.8 0.22 11.7 0.1 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat AdenylateSensor PF16579.5 EDN07112.1 - 0.063 13.7 0.5 52 4.3 0.0 3.7 3 1 1 4 4 4 0 Adenylate sensor of SNF1-like protein kinase Creatinase_N_2 PF16189.5 EDN07112.1 - 0.09 12.9 0.1 0.26 11.4 0.1 1.8 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain TPR_7 PF13176.6 EDN07112.1 - 0.33 11.1 3.8 30 5.0 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EDN07112.1 - 2.3 8.1 6.1 21 5.0 0.1 4.1 4 1 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal SAGA-Tad1 PF12767.7 EDN07113.1 - 2.6e-33 115.7 0.0 1.3e-26 93.8 0.0 2.2 1 1 1 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit Adhesin_Dr PF04619.12 EDN07113.1 - 0.1 12.6 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Dr-family adhesin FUSC_2 PF13515.6 EDN07114.1 - 6.4e-31 107.1 8.2 6.4e-31 107.1 8.2 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 EDN07114.1 - 4.7e-06 25.7 12.7 0.0011 17.9 8.7 3.3 3 1 0 3 3 3 2 Aluminium activated malate transporter ArAE_2 PF10334.9 EDN07114.1 - 0.0028 17.5 1.1 0.011 15.6 0.5 2.1 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC PF04632.12 EDN07114.1 - 0.19 10.2 22.6 0.049 12.2 12.9 3.0 2 1 0 2 2 2 0 Fusaric acid resistance protein family WD40 PF00400.32 EDN07115.1 - 1.1e-39 133.7 23.2 3.5e-05 24.5 0.3 11.2 10 1 1 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07115.1 - 9.6e-24 83.5 5.9 2.3e-06 27.8 0.0 8.5 4 3 5 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EDN07115.1 - 0.0013 18.6 4.3 5.2 7.1 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EDN07115.1 - 0.0019 17.2 1.6 15 4.4 0.0 5.3 4 2 3 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 EDN07115.1 - 0.0033 16.8 0.3 0.042 13.1 0.1 2.3 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Proteasome_A_N PF10584.9 EDN07115.1 - 0.2 11.4 2.7 6.1 6.6 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PQQ_3 PF13570.6 EDN07115.1 - 0.51 10.9 8.7 3.1 8.4 0.3 4.9 5 0 0 5 5 5 0 PQQ-like domain Ribosomal_S18 PF01084.20 EDN07116.1 - 1.5e-13 50.7 0.0 3.6e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S18 Tox-HNH-HHH PF15637.6 EDN07116.1 - 0.034 14.3 0.2 0.21 11.8 0.1 2.1 2 0 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Cro PF09048.10 EDN07116.1 - 0.08 13.0 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Cro PPR_2 PF13041.6 EDN07117.1 - 3.6e-13 49.5 0.2 0.1 12.8 0.0 6.4 7 0 0 7 7 7 4 PPR repeat family PPR PF01535.20 EDN07117.1 - 5.4e-06 26.3 7.4 0.67 10.3 0.1 5.9 7 0 0 7 7 7 2 PPR repeat PPR_3 PF13812.6 EDN07117.1 - 2.4e-05 24.3 1.2 1.4 9.0 0.1 5.1 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EDN07117.1 - 0.00012 21.5 1.8 0.35 10.2 0.1 4.5 4 2 1 5 5 5 1 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 EDN07117.1 - 0.0089 16.8 0.1 3.4 8.7 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN07117.1 - 0.04 14.4 0.4 6.5 7.3 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Vac14_Fig4_bd PF11916.8 EDN07117.1 - 0.048 13.3 0.3 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding TPR_1 PF00515.28 EDN07117.1 - 0.067 13.0 0.0 0.27 11.1 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat RPN7 PF10602.9 EDN07117.1 - 0.1 12.3 0.2 0.34 10.6 0.2 1.9 1 1 0 1 1 1 0 26S proteasome subunit RPN7 BTAD PF03704.17 EDN07117.1 - 0.17 12.3 2.6 7.1 7.0 0.0 3.8 4 0 0 4 4 4 0 Bacterial transcriptional activator domain Ribosomal_S14 PF00253.21 EDN07118.1 - 1.4e-15 56.7 3.9 1.5e-15 56.6 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.6 EDN07118.1 - 0.046 13.6 0.5 0.061 13.3 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) ELFV_dehydrog PF00208.21 EDN07119.1 - 6.1e-57 193.1 0.0 9.8e-57 192.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EDN07119.1 - 8e-15 53.5 0.1 7.8e-10 37.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EDN07119.1 - 0.0099 15.8 0.0 0.066 13.1 0.0 2.1 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Ish1 PF10281.9 EDN07119.1 - 0.091 13.1 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein TFIIIC_sub6 PF10419.9 EDN07122.1 - 5.4e-24 83.9 0.0 9.1e-24 83.2 0.0 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain Vps62 PF06101.11 EDN07123.1 - 4.8e-12 45.0 1.7 4.8e-12 45.0 1.7 1.8 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 62 DUF1302 PF06980.11 EDN07123.1 - 0.022 13.4 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1302) JmjC PF02373.22 EDN07124.1 - 1.8e-09 38.0 0.0 1.2e-08 35.4 0.0 2.2 1 1 0 1 1 1 1 JmjC domain, hydroxylase JHD PF17811.1 EDN07124.1 - 5e-09 36.6 0.3 1.1e-08 35.6 0.3 1.5 1 0 0 1 1 1 1 Jumonji helical domain Cupin_8 PF13621.6 EDN07124.1 - 1.4e-08 34.7 0.0 4.2e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 Cupin-like domain PHD PF00628.29 EDN07124.1 - 1.6e-07 31.1 4.3 1.6e-07 31.1 4.3 2.7 3 0 0 3 3 3 1 PHD-finger PHD_2 PF13831.6 EDN07124.1 - 0.0047 16.5 2.0 0.021 14.4 2.0 2.2 1 0 0 1 1 1 1 PHD-finger MRI PF15325.6 EDN07124.1 - 0.086 13.9 0.2 0.086 13.9 0.2 5.6 7 0 0 7 7 7 0 Modulator of retrovirus infection Zn_clus PF00172.18 EDN07124.1 - 0.59 10.3 26.8 0.27 11.4 4.7 3.0 3 0 0 3 3 3 0 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_1 PF00076.22 EDN07126.1 - 2.6e-19 68.8 0.3 4.4e-19 68.1 0.3 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN07126.1 - 5.5e-06 26.0 0.0 5.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN07126.1 - 0.0015 18.3 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif Frankia_peptide PF14407.6 EDN07126.1 - 0.094 12.7 0.2 11 6.1 0.0 2.7 2 1 1 3 3 3 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. STIMATE PF12400.8 EDN07127.1 - 1.1e-32 113.2 4.3 1.5e-32 112.8 4.3 1.1 1 0 0 1 1 1 1 STIMATE family TMEM43 PF07787.12 EDN07127.1 - 1.4 8.2 4.7 2 7.7 4.7 1.1 1 0 0 1 1 1 0 Transmembrane protein 43 Death PF00531.22 EDN07129.1 - 0.089 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Death domain Hexokinase_1 PF00349.21 EDN07130.1 - 1.9e-69 233.6 0.0 2.4e-69 233.3 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EDN07130.1 - 4.4e-53 180.2 0.0 6.9e-36 123.9 0.0 2.2 1 1 1 2 2 2 2 Hexokinase SIR2 PF02146.17 EDN07131.1 - 3.4e-54 183.5 0.0 5e-54 182.9 0.0 1.3 1 0 0 1 1 1 1 Sir2 family zf-dskA_traR PF01258.17 EDN07131.1 - 0.015 15.2 0.3 0.035 14.1 0.3 1.6 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger COG4 PF08318.12 EDN07132.1 - 6.6e-102 341.0 0.0 5.2e-66 223.0 0.0 2.3 1 1 1 2 2 2 2 COG4 transport protein Ammonium_transp PF00909.21 EDN07133.1 - 4.8e-113 377.9 29.9 5.6e-113 377.6 29.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family E1-E2_ATPase PF00122.20 EDN07134.1 - 3.6e-47 160.2 0.1 3.6e-47 160.2 0.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDN07134.1 - 2.3e-45 154.5 1.8 3.4e-45 154.0 0.2 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDN07134.1 - 4.9e-22 79.3 1.1 3e-20 73.4 0.9 3.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN07134.1 - 4.6e-21 74.3 0.0 1.1e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EDN07134.1 - 2.2e-10 40.5 0.0 5e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDN07134.1 - 8.3e-05 22.4 0.5 0.0009 19.0 0.5 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rad21_Rec8_N PF04825.13 EDN07135.1 - 2.6e-37 127.3 0.4 5.8e-37 126.2 0.0 1.7 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EDN07135.1 - 1.7e-08 33.6 0.0 3.5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein MFS_1 PF07690.16 EDN07136.1 - 2e-10 40.1 49.0 3.8e-10 39.2 24.2 3.4 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF2975 PF11188.8 EDN07136.1 - 1.2 9.0 14.5 14 5.6 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) RSRP PF17069.5 EDN07136.1 - 4.5 6.7 9.9 8.6 5.8 9.9 1.5 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Tyrosinase PF00264.20 EDN07137.1 - 1.4e-50 172.6 4.8 1.4e-50 172.6 4.8 2.4 2 1 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EDN07137.1 - 5.7e-12 46.4 0.0 1.3e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 Tyosinase C-terminal domain Ribosomal_L35Ae PF01247.18 EDN07139.1 - 0.048 13.8 0.0 0.099 12.8 0.0 1.7 1 1 0 1 1 1 0 Ribosomal protein L35Ae Rapsyn_N PF10579.9 EDN07139.1 - 0.072 13.2 0.0 0.077 13.1 0.0 1.1 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region Zn_clus PF00172.18 EDN07140.1 - 0.019 15.0 9.2 0.019 15.0 9.2 1.7 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EDN07140.1 - 0.085 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 PAS fold Flavokinase PF01687.17 EDN07141.1 - 3.7e-24 85.2 0.0 4.7e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase FSA_C PF10479.9 EDN07143.1 - 4.7 5.2 13.1 5.7 4.9 13.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RSN1_7TM PF02714.15 EDN07144.1 - 7.9e-86 287.8 31.5 7.9e-86 287.8 31.5 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDN07144.1 - 4.2e-46 156.6 0.6 4.2e-46 156.6 0.6 3.4 3 1 1 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDN07144.1 - 1.1e-28 100.7 1.2 9.5e-15 55.3 0.0 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDN07144.1 - 3.4e-12 46.4 0.0 1.1e-11 44.7 0.0 1.9 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter R3H PF01424.22 EDN07144.1 - 1 9.4 2.9 0.89 9.6 0.3 2.2 2 1 0 2 2 2 0 R3H domain Histone_HNS PF00816.21 EDN07144.1 - 5.4 7.9 7.0 5.5 7.9 3.5 2.3 2 0 0 2 2 2 0 H-NS histone family MCM PF00493.23 EDN07146.1 - 1.9e-102 341.1 0.0 2.6e-102 340.7 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDN07146.1 - 5.4e-39 132.9 0.1 9.6e-39 132.1 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDN07146.1 - 1.3e-27 96.0 0.9 2.9e-27 94.9 0.9 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDN07146.1 - 3.5e-19 69.3 0.0 1e-18 67.8 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDN07146.1 - 5.8e-06 25.8 0.0 0.00019 20.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDN07146.1 - 1e-05 25.5 0.0 2.9e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDN07146.1 - 0.00076 19.3 0.0 0.0032 17.3 0.0 2.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) VTC PF09359.10 EDN07147.1 - 3.5e-85 285.7 0.0 5.1e-85 285.2 0.0 1.2 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EDN07147.1 - 1.4e-15 58.2 12.5 3.5e-06 27.2 0.0 4.3 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 EDN07147.1 - 2e-13 50.6 2.5 3.8e-13 49.7 2.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) 7tm_3 PF00003.22 EDN07147.1 - 0.036 13.8 1.7 0.054 13.2 1.7 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR Ribophorin_I PF04597.14 EDN07148.1 - 5.9e-145 483.8 0.0 6.7e-145 483.6 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Pacs-1 PF10254.9 EDN07148.1 - 0.1 11.6 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Indigoidine_A PF04227.12 EDN07149.1 - 6.6e-110 367.1 0.7 1e-109 366.4 0.7 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EDN07149.1 - 2.9e-10 39.9 1.5 5.6e-05 22.6 0.1 2.4 2 0 0 2 2 2 2 pfkB family carbohydrate kinase Ank_2 PF12796.7 EDN07150.1 - 8.9e-05 23.0 0.2 0.021 15.4 0.1 2.3 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EDN07150.1 - 0.0066 16.8 0.9 0.03 14.8 0.9 2.2 1 1 0 1 1 1 1 Ankyrin repeat Methyltransf_25 PF13649.6 EDN07150.1 - 0.011 16.4 0.0 0.026 15.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Ank_4 PF13637.6 EDN07150.1 - 0.016 15.8 0.1 1.3 9.6 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN07150.1 - 0.025 14.9 0.2 10 6.6 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN07150.1 - 0.031 14.8 0.2 3.8 8.4 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat Ferritin_2 PF13668.6 EDN07151.1 - 2.5e-39 134.6 0.3 3.4e-39 134.1 0.3 1.2 1 0 0 1 1 1 1 Ferritin-like domain Band_7 PF01145.25 EDN07152.1 - 6.9e-18 65.3 2.7 9.9e-18 64.8 2.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 EDN07152.1 - 0.1 12.7 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 NB-ARC PF00931.22 EDN07152.1 - 0.38 9.9 1.8 0.23 10.6 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain CSTF2_hinge PF14327.6 EDN07153.1 - 4.8e-32 110.2 1.5 4.8e-32 110.2 1.5 3.2 3 0 0 3 3 3 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 EDN07153.1 - 4.7e-16 58.1 9.7 4.7e-16 58.1 9.7 3.1 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 EDN07153.1 - 1.9e-15 56.4 0.0 3.3e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN07153.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif DNA_methylase PF00145.17 EDN07154.1 - 1.5e-13 50.8 0.0 7.7e-13 48.5 0.0 1.9 2 0 0 2 2 2 1 C-5 cytosine-specific DNA methylase SNF2_N PF00176.23 EDN07154.1 - 2.3e-13 49.6 0.0 5.6e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Tektin PF03148.14 EDN07154.1 - 0.0052 15.6 0.7 0.0088 14.8 0.7 1.3 1 0 0 1 1 1 1 Tektin family ResIII PF04851.15 EDN07154.1 - 0.017 15.2 0.9 0.026 14.5 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDN07155.1 - 1.1e-05 25.7 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EDN07155.1 - 9.1e-05 22.3 6.4 0.00026 20.9 6.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDN07155.1 - 0.00065 19.7 3.7 0.0015 18.5 3.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDN07155.1 - 0.0034 17.2 5.2 0.0085 15.9 5.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN07155.1 - 0.0051 17.1 6.1 0.013 15.8 6.1 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDN07155.1 - 0.0079 16.1 6.9 0.019 14.9 6.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDN07155.1 - 0.13 12.6 2.4 0.4 11.0 2.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EDN07155.1 - 0.35 10.8 5.0 0.94 9.4 5.0 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDN07155.1 - 1 9.6 7.0 5 7.4 7.1 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EDN07155.1 - 3.5 7.6 6.7 34 4.4 6.9 2.3 1 1 1 2 2 2 0 zf-RING of BARD1-type protein 2Fe-2S_thioredx PF01257.19 EDN07156.1 - 2.2e-59 199.4 0.1 2.7e-59 199.2 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin SpoVS PF04232.12 EDN07157.1 - 0.039 13.7 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) RIP PF00161.19 EDN07157.1 - 0.21 11.1 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 Ribosome inactivating protein Sua5_yciO_yrdC PF01300.18 EDN07158.1 - 5.4e-53 179.1 0.0 9.1e-53 178.4 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EDN07158.1 - 1.9e-29 102.9 0.0 4.8e-29 101.6 0.0 1.6 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding NFACT-C PF11923.8 EDN07159.1 - 4.7e-38 129.3 0.1 4.7e-38 129.3 0.1 3.4 5 1 0 5 5 5 1 NFACT protein C-terminal domain FbpA PF05833.11 EDN07159.1 - 2.8e-29 102.2 7.8 1.7e-20 73.2 0.0 2.6 3 0 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EDN07159.1 - 2.1e-27 95.9 0.0 5.4e-27 94.6 0.0 1.7 1 0 0 1 1 1 1 NFACT protein RNA binding domain Clat_adaptor_s PF01217.20 EDN07160.1 - 7.1e-13 48.7 0.0 1.1e-11 44.9 0.2 1.9 2 0 0 2 2 2 1 Clathrin adaptor complex small chain DUF1515 PF07439.11 EDN07161.1 - 0.0059 16.6 4.6 0.0059 16.6 4.6 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1515) DUF724 PF05266.14 EDN07161.1 - 0.059 13.2 11.5 0.16 11.8 11.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Thg1C PF14413.6 EDN07161.1 - 0.089 13.0 1.0 0.24 11.6 1.0 1.7 1 0 0 1 1 1 0 Thg1 C terminal domain Bacillus_HBL PF05791.11 EDN07161.1 - 4.5 7.1 9.8 0.66 9.8 3.9 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ADIP PF11559.8 EDN07161.1 - 6.5 6.8 22.6 1.7 8.7 13.2 3.3 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Ribosomal_L7Ae PF01248.26 EDN07163.1 - 5.7e-25 86.9 0.0 6.6e-25 86.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L16 PF00252.18 EDN07164.1 - 3.8e-43 146.7 0.1 5e-43 146.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e TPR_1 PF00515.28 EDN07164.1 - 0.098 12.5 0.0 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat T2SSC PF11356.8 EDN07165.1 - 5.9 6.8 6.1 21 5.0 6.1 2.1 1 0 0 1 1 1 0 Type II secretion system protein C HA2 PF04408.23 EDN07166.1 - 4e-22 78.6 0.0 1.4e-21 76.7 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDN07166.1 - 1.6e-12 47.6 0.0 4e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDN07166.1 - 5e-11 42.9 0.0 1.9e-10 41.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN07166.1 - 0.0012 18.6 0.0 0.0084 15.9 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDN07166.1 - 0.0014 18.9 0.0 0.0076 16.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDN07166.1 - 0.0041 17.6 0.0 0.014 15.9 0.0 1.9 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EDN07166.1 - 0.014 15.2 0.0 0.039 13.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase PF06745.13 EDN07166.1 - 0.025 14.0 0.0 0.071 12.4 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 EDN07166.1 - 0.087 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Abhydrolase_6 PF12697.7 EDN07168.1 - 4.5e-11 43.8 0.0 6.3e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN07168.1 - 0.029 13.6 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDN07168.1 - 0.087 12.5 0.1 0.22 11.2 0.1 1.6 2 0 0 2 2 2 0 PGAP1-like protein Complex1_LYR_2 PF13233.6 EDN07170.1 - 3.6e-21 75.7 0.3 4.5e-21 75.4 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EDN07170.1 - 6.4e-11 42.1 0.1 1e-10 41.5 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Methyltransf_12 PF08242.12 EDN07171.1 - 0.017 15.8 0.1 0.35 11.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EDN07171.1 - 0.087 12.4 0.3 1.9 8.0 0.2 2.4 2 1 0 2 2 2 0 Methyltransferase small domain LSM PF01423.22 EDN07172.1 - 1.2e-17 63.4 0.0 1.5e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDN07172.1 - 0.0051 16.9 0.0 0.0065 16.6 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF5549 PF17703.1 EDN07172.1 - 0.06 13.0 0.5 0.068 12.8 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5549) GTP_EFTU PF00009.27 EDN07173.1 - 5e-07 29.5 0.0 1.1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDN07173.1 - 0.027 14.4 0.5 4.6 7.1 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase DDE_1 PF03184.19 EDN07174.1 - 1.7e-30 106.0 0.0 6.2e-30 104.1 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN07174.1 - 0.00038 20.2 0.0 0.0055 16.5 0.0 2.3 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EDN07174.1 - 0.0012 18.6 1.7 0.0023 17.6 1.7 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EDN07174.1 - 0.019 14.8 0.3 0.22 11.4 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN07174.1 - 0.036 13.8 0.5 0.067 12.9 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EDN07174.1 - 0.12 12.5 1.4 0.21 11.7 1.4 1.4 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 EDN07175.1 - 5.8e-33 114.3 0.0 9.7e-33 113.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN07175.1 - 3.1e-19 68.8 0.2 8e-19 67.5 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 EDN07175.1 - 3.7e-16 59.3 0.4 2e-13 50.5 0.2 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EDN07175.1 - 2.5e-15 56.7 0.0 7.2e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN07175.1 - 6.9e-14 51.5 1.5 2e-13 50.0 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RT_RNaseH_2 PF17919.1 EDN07175.1 - 1.1e-08 34.9 0.1 7e-08 32.4 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 EDN07175.1 - 1.8e-05 24.8 0.1 4e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN07175.1 - 0.035 14.3 1.0 0.37 11.0 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 PSII_Pbs27 PF13326.6 EDN07175.1 - 0.07 13.4 0.1 0.78 10.0 0.0 2.7 3 0 0 3 3 3 0 Photosystem II Pbs27 Retrotran_gag_2 PF14223.6 EDN07175.1 - 0.2 11.4 1.7 0.48 10.1 1.7 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type zf-C2H2 PF00096.26 EDN07177.1 - 8.1e-06 26.0 3.3 0.056 13.9 0.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN07177.1 - 8.5e-05 23.1 2.1 0.11 13.4 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger UPF0547 PF10571.9 EDN07177.1 - 0.0071 16.4 0.2 0.016 15.3 0.2 1.6 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 Pkr1 PF08636.10 EDN07178.1 - 7.6e-30 102.9 6.0 9.5e-30 102.6 6.0 1.1 1 0 0 1 1 1 1 ER protein Pkr1 ANAPC2 PF08672.11 EDN07180.1 - 2.1e-23 82.6 0.0 3e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 DNA_pol3_gamma3 PF12169.8 EDN07180.1 - 0.051 13.5 0.1 0.12 12.3 0.1 1.5 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III F-box-like PF12937.7 EDN07181.1 - 1.4e-06 28.1 0.2 3.1e-06 27.0 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN07181.1 - 0.0019 18.0 0.6 0.0038 17.1 0.2 1.7 2 0 0 2 2 2 1 F-box domain SesA PF17107.5 EDN07186.1 - 6.6e-17 61.8 0.0 1.7e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Ank_2 PF12796.7 EDN07186.1 - 7.1e-13 49.0 0.2 5.7e-05 23.6 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN07186.1 - 4.7e-11 42.7 1.9 0.0036 17.6 0.0 6.2 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN07186.1 - 6.2e-10 39.4 1.3 0.0055 17.3 0.1 6.1 5 2 3 8 8 8 3 Ankyrin repeats (many copies) Ank PF00023.30 EDN07186.1 - 0.015 15.8 1.8 1.1 9.9 0.0 4.4 4 1 0 4 4 4 0 Ankyrin repeat Ank_3 PF13606.6 EDN07186.1 - 0.052 14.1 1.6 8.7 7.3 0.0 4.8 5 0 0 5 5 5 0 Ankyrin repeat KAR9 PF08580.10 EDN07187.1 - 2.1e-208 694.2 20.7 2.1e-208 694.2 20.7 3.7 2 2 0 2 2 2 1 Yeast cortical protein KAR9 Laminin_II PF06009.12 EDN07187.1 - 0.059 13.4 5.3 4.9 7.2 0.0 3.7 3 1 1 4 4 4 0 Laminin Domain II Swi5 PF07061.11 EDN07187.1 - 0.14 12.3 0.2 16 5.7 0.1 2.9 2 0 0 2 2 2 0 Swi5 PEP-utilisers_N PF05524.13 EDN07187.1 - 0.29 11.3 1.9 0.4 10.9 0.3 2.1 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal CENP-Q PF13094.6 EDN07187.1 - 0.37 11.0 6.7 4.4 7.5 0.0 3.0 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Val_tRNA-synt_C PF10458.9 EDN07187.1 - 0.4 11.0 2.5 1.4 9.3 2.5 1.9 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm PRR18 PF15671.5 EDN07188.1 - 0.15 11.9 4.5 0.28 11.0 4.5 1.4 1 0 0 1 1 1 0 Proline-rich protein family 18 Acylphosphatase PF00708.18 EDN07189.1 - 2.1e-26 92.1 0.1 2.3e-26 92.0 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase DUF2871 PF11070.8 EDN07189.1 - 0.23 11.7 0.0 0.29 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) AOX PF01786.17 EDN07190.1 - 4e-100 333.8 0.2 5.2e-100 333.4 0.2 1.1 1 0 0 1 1 1 1 Alternative oxidase MBOAT PF03062.19 EDN07191.1 - 1.8e-30 106.5 18.0 7.7e-13 48.5 3.4 3.8 2 1 2 4 4 4 3 MBOAT, membrane-bound O-acyltransferase family PufQ PF05398.11 EDN07191.1 - 0.011 15.9 1.0 4.6 7.4 0.1 2.5 2 0 0 2 2 2 0 PufQ cytochrome subunit T4SS_CagC PF16943.5 EDN07191.1 - 0.064 13.4 0.4 0.15 12.2 0.4 1.6 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system zf-HIT PF04438.16 EDN07192.1 - 2.5e-10 40.1 8.5 3.8e-10 39.5 8.5 1.3 1 0 0 1 1 1 1 HIT zinc finger SOG2 PF10428.9 EDN07192.1 - 4.2 6.5 16.0 5.5 6.1 16.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Mucin PF01456.17 EDN07192.1 - 5.2 7.1 18.1 12 5.9 18.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Dopey_N PF04118.14 EDN07194.1 - 9.9e-118 392.7 0.2 9.7e-117 389.5 0.0 2.8 4 0 0 4 4 4 1 Dopey, N-terminal Mon1 PF03164.14 EDN07195.1 - 6.1e-118 394.4 0.0 1e-95 321.2 0.0 2.0 1 1 1 2 2 2 2 Trafficking protein Mon1 DEAD PF00270.29 EDN07196.1 - 3.3e-20 72.6 0.0 7.2e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN07196.1 - 5.4e-20 71.8 1.0 3.2e-19 69.3 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain RQC PF09382.10 EDN07196.1 - 4.6e-19 68.3 0.0 1.3e-18 66.8 0.0 1.8 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 EDN07196.1 - 8.1e-18 64.9 8.7 3.4e-17 62.9 8.7 2.2 1 0 0 1 1 1 1 RecQ zinc-binding HRDC PF00570.23 EDN07196.1 - 2.9e-10 40.0 0.0 1.2e-09 38.1 0.0 2.1 2 0 0 2 2 2 1 HRDC domain ResIII PF04851.15 EDN07196.1 - 0.00013 22.0 0.0 0.00033 20.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PLN_propep PF16485.5 EDN07196.1 - 0.14 11.9 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 Protealysin propeptide DUF4110 PF13422.6 EDN07197.1 - 1.3e-34 118.1 0.4 1.3e-34 118.1 0.4 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 EDN07197.1 - 1e-12 47.8 8.9 0.00028 20.8 0.0 5.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EDN07197.1 - 1.6e-12 47.4 10.1 0.00034 20.8 0.1 4.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EDN07197.1 - 3.6e-12 45.7 1.1 2.9e-06 27.0 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EDN07197.1 - 1.2e-11 44.0 0.5 1.3e-06 27.9 0.0 3.6 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 EDN07197.1 - 1.4e-11 44.2 1.4 0.00011 22.4 0.1 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EDN07197.1 - 4.1e-11 42.6 1.3 4.5e-06 26.5 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Pyridoxal_deC PF00282.19 EDN07198.1 - 1.2e-14 53.8 0.0 3.8e-14 52.2 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 EDN07198.1 - 0.035 13.3 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II RWP-RK PF02042.15 EDN07198.1 - 0.042 13.8 0.0 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 RWP-RK domain Hydrolase_4 PF12146.8 EDN07199.1 - 0.0083 15.4 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDN07199.1 - 0.036 13.7 0.0 0.24 11.0 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold CENP-K PF11802.8 EDN07200.1 - 1e-05 25.3 6.6 0.011 15.3 5.7 2.2 2 0 0 2 2 2 2 Centromere-associated protein K IFT46_B_C PF12317.8 EDN07200.1 - 0.11 12.2 2.3 2.7 7.6 0.2 2.3 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal SurA_N_2 PF13623.6 EDN07200.1 - 0.24 11.2 2.7 1.1 9.2 0.4 2.3 2 0 0 2 2 2 0 SurA N-terminal domain DUF4407 PF14362.6 EDN07200.1 - 0.35 10.2 18.9 0.37 10.1 8.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fzo_mitofusin PF04799.13 EDN07200.1 - 0.43 10.1 8.9 2.4 7.7 4.4 2.8 2 1 0 2 2 2 0 fzo-like conserved region OmpH PF03938.14 EDN07200.1 - 0.74 10.2 21.3 0.58 10.5 0.8 2.5 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF2089 PF09862.9 EDN07200.1 - 0.93 9.5 5.0 1 9.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) CDC37_N PF03234.14 EDN07200.1 - 1.2 10.0 15.0 0.22 12.5 4.7 2.9 3 0 0 3 3 3 0 Cdc37 N terminal kinase binding Fib_alpha PF08702.10 EDN07200.1 - 1.3 9.2 11.9 0.44 10.7 1.8 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1690 PF07956.11 EDN07200.1 - 6.5 7.2 13.3 6.9 7.1 6.4 2.7 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) KH_1 PF00013.29 EDN07201.1 - 2.4e-38 129.8 6.0 6.9e-13 48.2 1.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EDN07201.1 - 2.7e-10 39.9 2.0 0.0083 15.9 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EDN07201.1 - 5.1e-06 26.5 5.3 0.19 11.8 0.1 3.5 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 EDN07201.1 - 0.0002 21.2 0.3 0.79 9.6 0.1 3.3 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EDN07201.1 - 0.022 14.8 0.0 4.7 7.3 0.0 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain ABM PF03992.16 EDN07202.1 - 0.0083 16.2 0.2 0.79 9.9 0.0 2.3 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase Fungal_trans PF04082.18 EDN07204.1 - 3.8e-12 45.8 0.0 8.2e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN07204.1 - 7.7e-09 35.5 8.9 1.3e-08 34.8 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EDN07204.1 - 0.14 10.6 0.0 0.2 10.1 0.0 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B NUP214 PF16755.5 EDN07205.1 - 7.1e-12 45.2 0.0 4.8e-11 42.5 0.0 2.0 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 EDN07205.1 - 1.7e-05 25.1 0.0 0.01 16.1 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Golgin_A5 PF09787.9 EDN07205.1 - 0.0068 15.9 2.1 0.015 14.8 2.1 1.5 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF3708 PF12501.8 EDN07205.1 - 0.04 13.7 1.0 0.15 11.8 0.0 2.3 2 0 0 2 2 2 0 Phosphate ATP-binding cassette transporter DUF4407 PF14362.6 EDN07205.1 - 0.067 12.5 2.4 0.15 11.4 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 EDN07205.1 - 0.2 11.7 6.7 0.18 11.8 4.7 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5082 PF16888.5 EDN07205.1 - 0.35 11.1 4.2 34 4.8 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) DASH_Spc34 PF08657.10 EDN07205.1 - 0.48 10.2 2.3 0.41 10.4 0.2 2.0 3 0 0 3 3 3 0 DASH complex subunit Spc34 DUF4618 PF15397.6 EDN07205.1 - 0.74 9.2 8.0 4 6.8 8.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) SlyX PF04102.12 EDN07205.1 - 2.3 8.9 11.4 0.87 10.3 0.3 4.3 4 0 0 4 4 4 0 SlyX Proteasome PF00227.26 EDN07206.1 - 3.1e-45 154.0 0.1 3.8e-45 153.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EDN07206.1 - 3.5e-15 55.1 0.0 3.5e-15 55.1 0.0 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal RVT_2 PF07727.14 EDN07208.1 - 2.3e-43 148.6 0.0 3.3e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN07208.1 - 4.9e-12 46.1 0.0 1.4e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 EDN07208.1 - 0.00038 20.4 2.5 0.00084 19.3 2.5 1.5 1 0 0 1 1 1 1 Zinc knuckle gag_pre-integrs PF13976.6 EDN07208.1 - 0.0022 17.8 0.0 0.007 16.2 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN07208.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type CobT PF06213.12 EDN07208.1 - 0.52 9.7 3.8 1 8.7 3.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT U3_snoRNA_assoc PF08297.11 EDN07208.1 - 0.57 10.9 6.8 2.4 8.9 6.8 2.1 1 0 0 1 1 1 0 U3 snoRNA associated gag_pre-integrs PF13976.6 EDN07209.1 - 0.00023 20.9 0.1 0.0007 19.4 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 EDN07209.1 - 0.00029 20.8 2.7 0.00061 19.8 2.7 1.5 1 0 0 1 1 1 1 Zinc knuckle TetR_C_24 PF17932.1 EDN07209.1 - 0.069 13.4 0.0 9.3 6.6 0.0 2.7 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain SLD5_C PF16922.5 EDN07209.1 - 0.15 12.3 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus Peptidase_M3 PF01432.20 EDN07211.1 - 1.9e-123 413.1 0.0 2.3e-123 412.8 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 EDN07211.1 - 0.059 13.0 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Peptidase M50B-like ApoO PF09769.9 EDN07212.1 - 4.4e-40 136.6 0.1 2.6e-39 134.2 0.1 2.0 2 0 0 2 2 2 1 Apolipoprotein O GRASP55_65 PF04495.14 EDN07213.1 - 6.4e-40 136.7 0.0 5e-39 133.8 0.0 1.9 2 0 0 2 2 2 1 GRASP55/65 PDZ-like domain Methyltransf_15 PF09445.10 EDN07214.1 - 1.1e-50 171.4 0.0 1.4e-50 171.1 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EDN07214.1 - 1.3e-10 41.3 0.0 1.6e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 EDN07214.1 - 3.3e-08 33.5 0.0 2.1e-07 30.8 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 EDN07214.1 - 5.4e-06 26.2 0.0 7.8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 N6_Mtase PF02384.16 EDN07214.1 - 0.00042 19.7 0.0 0.00053 19.3 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_5 PF01795.19 EDN07214.1 - 0.0016 18.0 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family Methyltransf_18 PF12847.7 EDN07214.1 - 0.004 17.1 0.0 0.007 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN07214.1 - 0.0056 17.3 0.0 0.011 16.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN07214.1 - 0.036 14.7 0.0 0.063 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 EDN07214.1 - 0.049 12.8 0.0 0.083 12.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase MTS PF05175.14 EDN07214.1 - 0.057 13.0 0.0 0.085 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DNA_methylase PF00145.17 EDN07214.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase DUF3591 PF12157.8 EDN07215.1 - 4.6e-173 575.9 6.4 9.2e-172 571.7 6.4 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC PF00098.23 EDN07215.1 - 0.0047 16.9 0.7 0.0086 16.1 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 EDN07215.1 - 0.007 16.2 1.1 0.015 15.1 1.1 1.6 1 0 0 1 1 1 1 Zinc knuckle DUF2288 PF10052.9 EDN07215.1 - 0.07 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2288) Pkinase PF00069.25 EDN07216.1 - 8.7e-36 123.6 0.1 2.1e-18 66.6 0.0 3.3 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07216.1 - 2e-13 50.2 0.0 2.5e-06 27.0 0.0 3.3 2 1 1 3 3 3 3 Protein tyrosine kinase NPL PF17800.1 EDN07217.1 - 6.2e-30 103.9 0.0 6.2e-30 103.9 0.0 2.5 2 2 0 2 2 2 1 Nucleoplasmin-like domain FKBP_C PF00254.28 EDN07217.1 - 3.5e-14 52.9 0.3 3.1e-13 49.8 0.0 2.6 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase IMS PF00817.20 EDN07218.1 - 3.1e-41 140.9 0.0 5.9e-41 140.0 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EDN07218.1 - 4.5e-26 91.1 0.0 1.4e-25 89.5 0.0 1.9 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 EDN07218.1 - 4.5e-15 56.4 0.0 1.1e-14 55.2 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain UBM PF14377.6 EDN07218.1 - 6.6e-12 44.5 7.0 1.4e-07 30.7 0.1 4.0 3 0 0 3 3 3 2 Ubiquitin binding region BRCT_2 PF16589.5 EDN07218.1 - 2.1e-09 37.7 0.0 7.2e-09 35.9 0.0 2.0 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EDN07218.1 - 2.8e-05 24.4 0.0 0.00012 22.3 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain IMS_HHH PF11798.8 EDN07218.1 - 0.00026 21.1 0.2 0.0012 19.1 0.0 2.3 2 0 0 2 2 2 1 IMS family HHH motif LIG3_BRCT PF16759.5 EDN07218.1 - 0.00048 20.4 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain mCpol PF18182.1 EDN07218.1 - 0.0009 19.6 0.0 0.0023 18.3 0.0 1.7 1 0 0 1 1 1 1 minimal CRISPR polymerase domain PTCB-BRCT PF12738.7 EDN07218.1 - 0.0046 16.9 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain DJ-1_PfpI PF01965.24 EDN07219.1 - 3.4e-18 66.0 0.0 4.7e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF669 PF05037.13 EDN07219.1 - 0.0016 18.6 0.0 0.0026 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF669) GATase PF00117.28 EDN07219.1 - 0.058 13.2 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Aminotran_1_2 PF00155.21 EDN07220.1 - 8.1e-70 235.8 0.0 9.7e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF2334 PF10096.9 EDN07220.1 - 0.076 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) MSC PF09402.10 EDN07222.1 - 2.3e-105 352.8 0.0 2.9e-105 352.5 0.0 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EDN07222.1 - 2e-16 59.4 1.5 1.5e-15 56.6 0.1 2.7 3 0 0 3 3 3 1 HeH/LEM domain PP2C PF00481.21 EDN07223.1 - 8.9e-55 186.1 0.0 1.3e-54 185.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EDN07223.1 - 1.6e-19 69.4 31.5 4.5e-07 29.5 1.6 7.3 6 2 2 8 8 8 5 Leucine rich repeat LRR_4 PF12799.7 EDN07223.1 - 2.1e-17 62.9 37.1 0.00018 21.8 1.1 7.7 5 1 2 8 8 8 5 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EDN07223.1 - 8e-12 45.2 0.0 1.7e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.33 EDN07223.1 - 4.7e-07 29.5 24.2 26 5.9 0.0 10.8 11 1 0 11 11 11 0 Leucine Rich Repeat LRR_9 PF14580.6 EDN07223.1 - 1.8e-05 24.3 6.4 0.00047 19.7 0.6 2.5 2 0 0 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EDN07223.1 - 0.0037 17.2 0.5 0.013 15.4 0.5 1.9 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EDN07223.1 - 0.015 15.3 32.1 4.8 7.5 0.5 9.9 11 0 0 11 11 11 0 Leucine Rich repeat Calcipressin PF04847.12 EDN07225.1 - 4.7e-30 104.7 0.0 8.6e-30 103.9 0.0 1.4 1 1 0 1 1 1 1 Calcipressin Uds1 PF15456.6 EDN07226.1 - 5.6e-28 97.7 2.8 1.1e-27 96.7 2.8 1.5 1 0 0 1 1 1 1 Up-regulated During Septation Mst1_SARAH PF11629.8 EDN07226.1 - 0.29 11.3 1.7 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 GrpE PF01025.19 EDN07227.1 - 2.1e-41 141.4 3.6 3e-41 140.8 3.6 1.2 1 0 0 1 1 1 1 GrpE DUF2277 PF10041.9 EDN07227.1 - 0.088 13.2 0.2 0.23 11.8 0.1 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) Peptidase_S49 PF01343.18 EDN07227.1 - 0.097 12.6 1.0 0.16 12.0 1.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 tRNA-synt_2d PF01409.20 EDN07228.1 - 1.7e-47 162.0 0.2 4.2e-26 91.9 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EDN07228.1 - 2.5e-25 88.7 0.0 6e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain NAPRTase_C PF17956.1 EDN07228.1 - 0.075 13.5 0.5 0.19 12.1 0.1 1.9 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain Arg_decarbox_C PF17944.1 EDN07228.1 - 0.19 12.3 0.8 21 5.7 0.1 2.6 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension Mito_carr PF00153.27 EDN07229.1 - 5.9e-60 199.2 0.1 1.3e-18 66.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein COX6B PF02297.17 EDN07230.1 - 1.7e-18 66.6 4.8 2e-18 66.4 4.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.14 EDN07230.1 - 0.014 15.3 0.2 0.019 14.9 0.2 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain CX9C PF16860.5 EDN07230.1 - 0.038 14.0 2.2 0.061 13.4 2.2 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, ketoacyl-synt PF00109.26 EDN07230.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain RRM_1 PF00076.22 EDN07232.1 - 1.4e-16 60.0 0.0 1.9e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN07232.1 - 0.016 15.3 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EDN07232.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EDN07232.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Limkain b1 SRA1 PF07304.11 EDN07233.1 - 5.2e-09 36.0 10.1 5.2e-09 36.0 10.1 3.2 2 2 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 EDN07233.1 - 1e-05 25.4 0.3 8.1e-05 22.4 0.3 2.0 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 EDN07233.1 - 2.8e-05 24.8 2.6 0.5 11.3 0.0 5.5 5 0 0 5 5 5 1 WD domain, G-beta repeat Prp18 PF02840.15 EDN07233.1 - 0.019 15.0 0.1 0.051 13.6 0.0 1.8 2 0 0 2 2 2 0 Prp18 domain ANAPC4_WD40 PF12894.7 EDN07233.1 - 0.029 14.6 0.2 0.94 9.8 0.1 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Pex14_N PF04695.13 EDN07235.1 - 2.1e-41 142.2 1.1 2.1e-41 142.2 1.1 2.1 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PAPA-1 PF04795.12 EDN07236.1 - 2.7e-33 114.6 3.8 2.7e-33 114.6 3.8 2.5 3 0 0 3 3 3 1 PAPA-1-like conserved region Mus7 PF09462.10 EDN07238.1 - 1.5e-176 588.9 7.2 2e-176 588.5 7.2 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family DUF4050 PF13259.6 EDN07239.1 - 4.7e-56 190.0 0.2 4.7e-56 190.0 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) AAA PF00004.29 EDN07240.1 - 2.9e-38 131.3 0.0 3.5e-37 127.8 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN07240.1 - 2.1e-08 33.9 0.0 5e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDN07240.1 - 5.2e-05 23.7 1.5 0.0017 18.8 0.0 3.3 2 2 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EDN07240.1 - 6.5e-05 23.2 0.6 0.0063 16.8 0.1 3.3 3 1 1 4 4 3 1 AAA domain AAA_5 PF07728.14 EDN07240.1 - 7.4e-05 22.8 0.1 0.0007 19.6 0.0 2.7 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDN07240.1 - 0.00025 20.8 0.0 0.00063 19.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EDN07240.1 - 0.00027 21.1 0.0 0.0016 18.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EDN07240.1 - 0.00059 19.1 0.0 0.0012 18.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EDN07240.1 - 0.0034 16.8 0.1 0.0092 15.4 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDN07240.1 - 0.0057 16.9 0.0 0.02 15.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EDN07240.1 - 0.0063 16.3 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EDN07240.1 - 0.015 15.3 0.0 0.1 12.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDN07240.1 - 0.032 14.6 0.0 0.091 13.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EDN07240.1 - 0.038 13.7 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EDN07240.1 - 0.038 14.4 0.4 0.11 12.9 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EDN07240.1 - 0.052 14.1 0.0 0.14 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDN07240.1 - 0.054 12.9 0.0 0.21 11.0 0.0 1.9 1 1 1 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 EDN07240.1 - 0.082 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EDN07240.1 - 0.099 12.3 0.1 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 EDN07240.1 - 0.1 12.0 0.0 0.28 10.5 0.0 1.7 2 0 0 2 2 2 0 Isopentenyl transferase SHQ1 PF04925.15 EDN07240.1 - 0.21 11.1 0.0 0.43 10.1 0.0 1.4 1 0 0 1 1 1 0 SHQ1 protein LIM_bind PF01803.16 EDN07242.1 - 6.6e-61 205.9 0.0 6.6e-61 205.9 0.0 4.7 3 1 0 3 3 3 1 LIM-domain binding protein Membralin PF09746.9 EDN07242.1 - 1.8 7.5 14.9 5.1 6.0 14.9 1.8 1 0 0 1 1 1 0 Tumour-associated protein DUF2151 PF10221.9 EDN07242.1 - 2.3 6.7 18.3 3.8 6.0 18.3 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator cobW PF02492.19 EDN07244.1 - 6.1e-35 120.4 0.0 7.4e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EDN07244.1 - 4.9e-05 22.4 0.6 0.00068 18.7 0.6 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EDN07244.1 - 0.012 16.1 0.0 0.017 15.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDN07244.1 - 0.018 15.1 0.0 0.055 13.6 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 EDN07244.1 - 0.084 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 EDN07244.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA12 PF10443.9 EDN07244.1 - 0.22 10.2 0.0 0.34 9.6 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein ResIII PF04851.15 EDN07244.1 - 0.24 11.4 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit BING4CT PF08149.11 EDN07245.1 - 6.6e-39 131.6 0.0 2.3e-34 117.0 0.0 3.1 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EDN07245.1 - 3.9e-08 33.5 0.0 7.1 7.0 0.0 6.1 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN07245.1 - 0.00022 21.9 0.4 4.9 8.2 0.0 4.5 4 1 1 5 5 5 2 WD domain, G-beta repeat RIBIOP_C PF04950.12 EDN07246.1 - 2.5e-108 361.9 0.0 5.1e-108 360.9 0.0 1.5 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDN07246.1 - 9.1e-22 77.0 0.0 2.1e-21 75.8 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain DUF726 PF05277.12 EDN07247.1 - 1.2e-126 422.3 1.9 1.6e-126 421.9 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Glu-tRNAGln PF02686.15 EDN07247.1 - 1.3e-08 35.0 0.2 5.6e-08 33.0 0.2 2.2 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Thioesterase PF00975.20 EDN07247.1 - 4.6e-05 23.6 1.8 0.00051 20.2 0.0 2.6 3 0 0 3 3 3 1 Thioesterase domain Hydrolase_4 PF12146.8 EDN07247.1 - 0.044 13.1 0.0 0.082 12.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Phage_holin_3_6 PF07332.11 EDN07247.1 - 0.072 13.1 6.4 0.21 11.6 6.4 1.8 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Abhydrolase_6 PF12697.7 EDN07247.1 - 0.085 13.5 3.0 0.15 12.6 0.0 2.2 1 1 0 2 2 2 0 Alpha/beta hydrolase family PE-PPE PF08237.11 EDN07247.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 PE-PPE domain DUF2062 PF09835.9 EDN07247.1 - 0.97 9.3 5.0 2.3 8.1 5.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) TcdA_TcdB_pore PF12920.7 EDN07247.1 - 2.8 6.1 5.1 4.7 5.3 5.1 1.2 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain SNAP PF14938.6 EDN07248.1 - 8.2e-115 383.1 15.5 9.3e-115 382.9 15.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EDN07248.1 - 5.8e-08 32.9 11.2 0.014 15.7 0.5 3.9 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07248.1 - 0.0025 17.9 14.6 0.16 12.2 0.2 5.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN07248.1 - 0.0077 16.3 16.9 1.5 9.1 0.2 6.7 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDN07248.1 - 0.022 14.6 2.7 3 7.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DFF40 PF09230.10 EDN07248.1 - 0.084 12.5 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa TPR_16 PF13432.6 EDN07248.1 - 0.19 12.4 16.4 5.2 7.8 2.4 4.9 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDN07248.1 - 0.48 10.3 17.1 3.4 7.7 0.5 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN07248.1 - 1.1 10.0 15.5 32 5.4 0.2 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 EDN07248.1 - 2.6 8.1 10.5 2 8.5 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 EDN07248.1 - 2.6 9.2 19.0 4.7 8.4 0.8 6.7 7 0 0 7 7 6 0 Aromatic-di-Alanine (AdAR) repeat Ank PF00023.30 EDN07249.1 - 0.00022 21.5 1.8 0.0059 17.0 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EDN07249.1 - 0.00062 20.0 0.1 0.023 15.2 0.0 3.0 2 1 0 2 2 2 1 Ankyrin repeat Torsin PF06309.11 EDN07249.1 - 0.0008 19.5 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 Torsin Ank_2 PF12796.7 EDN07249.1 - 0.006 17.1 0.1 0.017 15.7 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) AAA PF00004.29 EDN07249.1 - 0.012 16.0 0.1 0.074 13.5 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ank_4 PF13637.6 EDN07249.1 - 0.032 14.8 0.0 0.12 13.0 0.0 2.1 1 1 0 1 1 1 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN07249.1 - 0.038 14.3 0.2 0.38 11.1 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) ClpB_D2-small PF10431.9 EDN07249.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein Pyr_redox_2 PF07992.14 EDN07254.1 - 0.0033 16.7 0.0 0.0058 15.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Sec62 PF03839.16 EDN07256.1 - 2.2e-75 252.9 0.7 2.2e-75 252.9 0.7 2.0 2 0 0 2 2 2 1 Translocation protein Sec62 SinI PF08671.10 EDN07256.1 - 0.0016 18.2 0.5 2.9 7.7 0.1 2.8 3 0 0 3 3 3 2 Anti-repressor SinI T3SS_needle_E PF08988.10 EDN07256.1 - 0.064 13.4 1.2 0.064 13.4 1.2 3.0 2 1 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle PH PF00169.29 EDN07257.1 - 0.022 15.3 0.0 0.067 13.7 0.0 1.8 1 1 0 1 1 1 0 PH domain Carn_acyltransf PF00755.20 EDN07259.1 - 1.2e-203 678.0 0.0 1.3e-203 677.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Rxt3 PF08642.10 EDN07260.1 - 1.7e-45 154.9 0.0 1.3e-44 152.0 0.0 2.3 1 1 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EDN07260.1 - 0.00061 19.8 0.0 0.0018 18.4 0.0 1.7 2 0 0 2 2 2 1 LCCL domain FmiP_Thoc5 PF09766.9 EDN07261.1 - 0.063 12.5 2.4 0.072 12.4 2.4 1.0 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 RVT_1 PF00078.27 EDN07261.1 - 0.12 11.8 0.0 0.12 11.8 0.0 1.0 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3435 PF11917.8 EDN07262.1 - 3e-129 431.6 0.5 3.7e-129 431.3 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2 PF00096.26 EDN07262.1 - 5.3 7.7 8.3 18 6.0 0.3 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type Pkinase_fungal PF17667.1 EDN07263.1 - 4.4e-127 424.3 0.0 5.6e-127 423.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase MauJ PF17419.2 EDN07263.1 - 0.059 12.8 0.1 0.38 10.2 0.0 2.0 2 0 0 2 2 2 0 Methylamine utilization protein MauJ Caskin-Pro-rich PF16907.5 EDN07263.1 - 0.17 12.4 10.1 2 9.0 3.4 2.4 2 0 0 2 2 2 0 Proline rich region of Caskin proteins DEAD PF00270.29 EDN07265.1 - 2.1e-09 37.4 0.0 6.1e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN07265.1 - 7.6e-05 22.8 0.0 0.00019 21.5 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN07265.1 - 0.04 14.2 0.1 0.16 12.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain CLN3 PF02487.17 EDN07268.1 - 1.4e-143 478.8 0.1 1.9e-143 478.3 0.1 1.1 1 0 0 1 1 1 1 CLN3 protein F-box-like PF12937.7 EDN07268.1 - 8.3e-07 28.8 0.1 1.6e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN07268.1 - 1.3e-05 25.0 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain Abhydrolase_3 PF07859.13 EDN07269.1 - 1.5e-35 123.0 0.0 2.9e-26 92.6 0.0 2.8 2 0 0 2 2 2 2 alpha/beta hydrolase fold Aminotran_3 PF00202.21 EDN07270.1 - 8.3e-106 354.0 0.0 1e-105 353.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDN07270.1 - 5.5e-06 25.8 0.0 9.4e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1674 PF07896.12 EDN07271.1 - 1.1e-10 41.8 0.4 2.8e-10 40.5 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) HMGL-like PF00682.19 EDN07272.1 - 7.2e-43 147.0 0.0 1.1e-42 146.5 0.0 1.3 1 1 0 1 1 1 1 HMGL-like Pkinase PF00069.25 EDN07274.1 - 1.3e-19 70.6 0.0 7.1e-14 51.8 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07274.1 - 0.00075 18.9 0.0 0.35 10.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Diphthamide_syn PF01866.17 EDN07275.1 - 1.8e-116 388.8 0.0 2.3e-116 388.5 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Bromodomain PF00439.25 EDN07276.1 - 2.2e-07 30.8 0.0 0.00017 21.6 0.0 2.2 2 0 0 2 2 2 2 Bromodomain Cas_Cas02710 PF09670.10 EDN07276.1 - 0.2 10.5 0.1 0.25 10.1 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) AIRC PF00731.20 EDN07278.1 - 4.5e-58 195.0 1.3 9.8e-58 193.9 1.3 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EDN07278.1 - 2.4e-53 180.2 0.0 4.1e-53 179.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EDN07278.1 - 3.2e-19 68.3 0.2 7.8e-19 67.1 0.0 1.8 2 0 0 2 2 2 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 EDN07278.1 - 1.9e-05 24.3 0.2 5.8e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PrpR_N PF06506.11 EDN07278.1 - 0.00028 20.5 0.3 0.0014 18.2 0.1 2.2 2 0 0 2 2 2 1 Propionate catabolism activator Dala_Dala_lig_C PF07478.13 EDN07278.1 - 0.0033 17.0 0.0 0.027 14.0 0.0 2.2 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus zf-C2HC PF01530.18 EDN07278.1 - 4.7 7.5 4.9 9.1 6.6 0.2 2.8 3 0 0 3 3 3 0 Zinc finger, C2HC type Glyco_hydro_63 PF03200.16 EDN07279.1 - 3.3e-07 29.5 1.0 3.3e-07 29.5 1.0 4.1 4 1 0 4 4 4 1 Glycosyl hydrolase family 63 C-terminal domain Neugrin PF06413.11 EDN07280.1 - 1.8e-10 41.3 0.8 4.2e-10 40.0 0.2 1.8 1 1 1 2 2 2 1 Neugrin MRP-L20 PF12824.7 EDN07280.1 - 1.8e-07 31.5 2.0 4e-07 30.4 2.0 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 UPF0240 PF06784.11 EDN07280.1 - 0.02 14.9 0.1 0.04 14.0 0.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0240) HTH_32 PF13565.6 EDN07280.1 - 0.043 14.4 1.0 0.043 14.4 1.0 2.0 2 1 0 2 2 2 0 Homeodomain-like domain Sigma70_r4 PF04545.16 EDN07280.1 - 0.23 11.0 1.5 3.3 7.3 0.0 2.8 3 0 0 3 3 3 0 Sigma-70, region 4 Rgp1 PF08737.10 EDN07281.1 - 6.9e-129 430.7 0.0 1.2e-128 429.9 0.0 1.4 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 EDN07281.1 - 0.00025 21.1 0.0 0.00058 19.9 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EDN07281.1 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 SpoOM protein Mob1_phocein PF03637.17 EDN07283.1 - 8.3e-74 247.2 0.0 1.1e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family OSCP PF00213.18 EDN07284.1 - 3.2e-41 141.3 1.2 4e-41 141.0 1.2 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit LPD26 PF18842.1 EDN07284.1 - 0.047 13.7 0.2 0.096 12.7 0.2 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 26 DrrA_P4M PF14860.6 EDN07284.1 - 0.047 13.5 0.1 0.12 12.2 0.0 1.8 2 1 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain WD40 PF00400.32 EDN07285.1 - 5.2e-09 36.6 8.8 0.0059 17.4 0.0 7.2 8 0 0 8 8 8 4 WD domain, G-beta repeat DDE_Tnp_1_7 PF13843.6 EDN07287.1 - 7.4e-26 91.3 0.9 3.3e-16 59.5 0.2 3.2 2 2 1 3 3 3 3 Transposase IS4 Mur_ligase_C PF02875.21 EDN07287.1 - 0.084 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain RD3 PF14473.6 EDN07287.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 RD3 protein SPO22 PF08631.10 EDN07288.1 - 2.8e-42 145.1 11.5 7.9e-23 81.3 0.0 4.7 4 2 1 5 5 5 3 Meiosis protein SPO22/ZIP4 like CENP-Q PF13094.6 EDN07290.1 - 1.5e-46 158.7 4.0 2.3e-46 158.1 4.0 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Spc24 PF08286.11 EDN07290.1 - 0.72 10.1 4.1 0.9 9.8 1.8 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF2203 PF09969.9 EDN07290.1 - 0.79 10.5 3.8 2 9.2 1.8 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) ZapB PF06005.12 EDN07290.1 - 1.4 9.4 11.9 0.5 10.8 8.3 2.0 2 0 0 2 2 2 0 Cell division protein ZapB HLH PF00010.26 EDN07291.1 - 8.9e-07 28.8 0.0 2.2e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain WT1 PF02165.15 EDN07293.1 - 0.16 11.2 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Wilm's tumour protein DNA_pol3_delta2 PF13177.6 EDN07294.1 - 9.6e-11 41.7 0.1 2.3e-10 40.5 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EDN07294.1 - 7.5e-06 26.4 0.1 1.5e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN07294.1 - 0.00023 21.4 0.4 0.0009 19.5 0.3 2.1 1 1 1 2 2 2 1 AAA domain Rep_fac_C PF08542.11 EDN07294.1 - 0.00026 21.3 0.1 0.0011 19.4 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_16 PF13191.6 EDN07294.1 - 0.00062 20.2 0.8 0.013 15.9 0.4 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EDN07294.1 - 0.0022 17.7 0.3 0.005 16.6 0.3 1.5 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EDN07294.1 - 0.027 14.3 0.3 0.046 13.5 0.3 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Rad17 PF03215.15 EDN07294.1 - 0.042 13.8 0.0 0.086 12.8 0.0 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain Resolvase PF00239.21 EDN07294.1 - 0.08 13.1 0.1 1.5 8.9 0.2 2.3 2 0 0 2 2 2 0 Resolvase, N terminal domain T4SS-DNA_transf PF02534.14 EDN07294.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Ribosomal_L16 PF00252.18 EDN07295.1 - 7.8e-32 110.0 0.6 1e-31 109.7 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Pkinase PF00069.25 EDN07296.1 - 7.8e-20 71.3 0.0 1.3e-19 70.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07296.1 - 2.6e-10 40.0 0.0 3.4e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN07296.1 - 0.011 14.6 0.1 0.014 14.2 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EDN07296.1 - 0.17 11.2 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Kinase-like F-box-like PF12937.7 EDN07297.1 - 2.3e-06 27.4 0.1 2.5e-05 24.1 0.2 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EDN07297.1 - 0.0031 17.3 1.9 0.0031 17.3 1.9 4.1 4 1 0 4 4 4 1 F-box domain F-box-like_2 PF13013.6 EDN07297.1 - 0.0074 16.2 0.6 0.046 13.7 0.1 2.5 2 1 1 3 3 3 1 F-box-like domain NHR2 PF08788.11 EDN07297.1 - 0.11 12.2 0.0 18 5.2 0.0 2.6 2 0 0 2 2 2 0 NHR2 domain like APH PF01636.23 EDN07298.1 - 1.2e-07 31.9 0.0 5.7e-07 29.7 0.0 2.1 2 2 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDN07298.1 - 0.012 15.3 0.5 1.3 8.6 0.1 2.8 1 1 2 3 3 3 0 RIO1 family Yop-YscD_ppl PF16693.5 EDN07298.1 - 0.12 11.7 0.2 0.46 9.9 0.1 1.8 1 1 1 2 2 2 0 Inner membrane component of T3SS, periplasmic domain RFC1 PF08519.12 EDN07299.1 - 5e-61 205.5 0.6 2e-60 203.5 0.1 2.2 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EDN07299.1 - 2.7e-13 50.1 0.0 6.8e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EDN07299.1 - 1.1e-09 38.8 0.2 9e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDN07299.1 - 4.7e-05 23.4 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_33 PF13671.6 EDN07299.1 - 0.00039 20.6 0.0 0.0028 17.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN07299.1 - 0.00051 20.3 0.0 0.0013 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN07299.1 - 0.0033 17.8 0.0 0.016 15.6 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDN07299.1 - 0.0075 16.0 0.0 0.02 14.6 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN07299.1 - 0.026 15.1 0.0 0.078 13.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDN07299.1 - 0.041 13.9 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN07299.1 - 0.068 13.2 0.0 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDN07299.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 EDN07299.1 - 0.16 12.2 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDN07299.1 - 0.74 9.5 0.0 0.74 9.5 0.0 4.5 4 1 0 4 4 4 0 AAA domain NAD_binding_8 PF13450.6 EDN07300.1 - 4.9e-16 58.7 0.0 1.1e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EDN07300.1 - 4e-09 36.3 0.0 6.8e-08 32.2 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EDN07300.1 - 0.013 15.1 0.0 0.04 13.5 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN07300.1 - 0.079 12.2 0.0 0.18 11.0 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDN07300.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EDN07300.1 - 0.16 12.6 0.1 8.5 7.0 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Uds1 PF15456.6 EDN07302.1 - 0.11 12.6 1.8 0.24 11.6 1.8 1.5 1 0 0 1 1 1 0 Up-regulated During Septation Mito_carr PF00153.27 EDN07303.1 - 9.3e-60 198.6 5.7 4.7e-19 68.1 0.0 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein UPF0121 PF03661.13 EDN07304.1 - 6.8e-28 97.7 5.1 9e-28 97.3 5.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Septin PF00735.18 EDN07305.1 - 1.8e-121 404.8 0.2 1.8e-121 404.8 0.2 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDN07305.1 - 1.6e-08 34.6 0.5 3.8e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDN07305.1 - 1.8e-05 24.3 2.3 0.0025 17.4 0.0 3.0 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EDN07305.1 - 0.0002 21.9 4.4 0.02 15.4 0.0 2.9 2 1 0 3 3 3 1 ABC transporter AAA_16 PF13191.6 EDN07305.1 - 0.0012 19.3 0.1 0.0045 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EDN07305.1 - 0.0015 18.7 0.0 0.0038 17.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EDN07305.1 - 0.0016 18.7 0.8 0.014 15.7 0.0 2.7 2 2 0 2 2 2 1 AAA domain Ras PF00071.22 EDN07305.1 - 0.0029 17.2 0.0 0.013 15.1 0.0 2.2 1 1 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 EDN07305.1 - 0.0032 17.4 1.0 0.0032 17.4 1.0 3.7 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 EDN07305.1 - 0.0041 16.5 0.0 0.0041 16.5 0.0 2.3 2 1 0 2 2 2 1 AIG1 family AAA_29 PF13555.6 EDN07305.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EDN07305.1 - 0.016 15.0 3.5 0.52 10.0 0.0 3.2 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EDN07305.1 - 0.028 14.5 8.0 0.78 9.8 0.0 3.9 4 1 0 4 4 4 0 Dynamin family AAA_23 PF13476.6 EDN07305.1 - 0.048 14.2 8.1 8.1 6.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN07305.1 - 0.057 13.1 0.1 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDN07305.1 - 0.07 13.5 0.8 0.53 10.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 EDN07305.1 - 0.084 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2937 PF11157.8 EDN07305.1 - 0.11 12.2 2.6 0.22 11.2 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Exonuc_VII_L PF02601.15 EDN07305.1 - 0.14 11.7 7.1 0.23 11.0 7.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Caldesmon PF02029.15 EDN07305.1 - 0.14 10.9 16.6 0.21 10.3 16.6 1.4 1 0 0 1 1 1 0 Caldesmon DUF87 PF01935.17 EDN07305.1 - 0.61 10.1 4.4 3.9 7.5 0.0 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain DUF3987 PF13148.6 EDN07305.1 - 1.2 8.1 8.4 1.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Atg14 PF10186.9 EDN07305.1 - 3 6.9 9.9 4.6 6.2 9.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPK_catalytic PF04263.16 EDN07306.1 - 2e-26 92.4 0.0 3.5e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EDN07306.1 - 1.8e-18 66.0 0.0 3.6e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Prismane PF03063.20 EDN07306.1 - 0.11 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family MIF4G PF02854.19 EDN07307.1 - 4.2e-54 183.4 0.0 1.6e-26 93.3 0.0 3.6 4 0 0 4 4 4 2 MIF4G domain Upf2 PF04050.14 EDN07307.1 - 3.7e-42 144.3 12.2 3.7e-42 144.3 12.2 2.6 2 0 0 2 2 2 1 Up-frameshift suppressor 2 p450 PF00067.22 EDN07308.1 - 9.3e-46 156.5 0.1 1.3e-45 156.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_8 PF13450.6 EDN07309.1 - 1.1e-08 35.2 0.0 2.4e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 EDN07309.1 - 1.3e-08 33.8 1.2 0.00035 19.1 0.5 2.9 2 2 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDN07309.1 - 1e-05 25.0 0.3 6.6e-05 22.3 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDN07309.1 - 7.6e-05 22.5 0.0 0.0069 16.0 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDN07309.1 - 0.00017 21.6 0.0 0.0055 16.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EDN07309.1 - 0.00087 18.6 0.1 0.0016 17.8 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EDN07309.1 - 0.0086 15.2 0.3 0.014 14.5 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EDN07309.1 - 0.0099 15.1 0.1 1.2 8.3 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EDN07309.1 - 0.04 14.0 0.4 0.21 11.6 0.1 2.3 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.7 EDN07309.1 - 0.089 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EDN07309.1 - 0.23 10.7 0.4 0.38 10.0 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EDN07309.1 - 0.75 8.4 1.8 1.2 7.8 1.8 1.2 1 0 0 1 1 1 0 HI0933-like protein Glyco_transf_8 PF01501.20 EDN07311.1 - 1.7e-12 47.5 0.0 3.1e-12 46.6 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 SUN PF03856.13 EDN07312.1 - 3.5e-92 308.3 11.2 4.4e-92 308.0 11.2 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Ribosomal_L1 PF00687.21 EDN07315.1 - 1.1e-63 214.6 3.5 1.6e-63 214.1 3.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family ETF PF01012.21 EDN07316.1 - 2e-45 154.9 3.4 3.4e-45 154.2 3.4 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EDN07316.1 - 4.4e-33 113.1 0.1 1e-32 112.0 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain DDE_Tnp_4 PF13359.6 EDN07317.1 - 6.9e-23 81.1 0.0 1.3e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 EDN07317.1 - 6.2e-08 32.5 0.0 2e-07 30.9 0.0 1.8 1 1 0 1 1 1 1 Transposase DDE domain Plant_tran PF04827.14 EDN07317.1 - 0.0071 16.0 0.0 0.015 14.9 0.0 1.5 1 1 0 1 1 1 1 Plant transposon protein DUF434 PF04256.12 EDN07317.1 - 0.023 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF434) HTH_Tnp_4 PF13613.6 EDN07317.1 - 0.15 11.8 0.2 0.31 10.8 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Clusterin PF01093.17 EDN07317.1 - 0.28 10.2 2.7 0.29 10.1 0.4 2.0 2 1 0 2 2 2 0 Clusterin AAA PF00004.29 EDN07319.1 - 8.3e-12 45.7 0.0 1.7e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN07319.1 - 9.9e-07 29.1 0.0 2.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDN07319.1 - 1.9e-06 27.9 0.0 6e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EDN07319.1 - 3.2e-06 27.2 0.0 1.4e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EDN07319.1 - 4.7e-05 23.2 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EDN07319.1 - 0.00069 19.8 0.0 0.0017 18.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN07319.1 - 0.0014 19.0 0.0 0.0097 16.3 0.0 2.3 3 0 0 3 3 2 1 AAA ATPase domain AAA_14 PF13173.6 EDN07319.1 - 0.0042 17.1 0.0 0.0082 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDN07319.1 - 0.0068 16.3 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase NTPase_1 PF03266.15 EDN07319.1 - 0.036 14.0 0.1 0.093 12.6 0.1 1.8 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 EDN07319.1 - 0.039 14.5 0.0 0.13 12.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain TsaE PF02367.17 EDN07319.1 - 0.047 13.7 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDN07319.1 - 0.083 12.2 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 EDN07319.1 - 0.086 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 EDN07319.1 - 0.1 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDN07319.1 - 0.11 12.2 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN07319.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EDN07319.1 - 0.14 11.3 0.0 0.62 9.2 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_28 PF13521.6 EDN07319.1 - 0.16 12.2 0.0 0.46 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain SWIRM-assoc_1 PF16495.5 EDN07320.1 - 7.2e-31 106.0 7.8 1.6e-30 104.9 7.8 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 SWIRM PF04433.17 EDN07320.1 - 8.2e-31 106.2 0.1 1.7e-30 105.2 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 EDN07320.1 - 1.7e-09 37.7 0.0 4.7e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN07320.1 - 1.1e-06 28.8 0.1 2.4e-06 27.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA_9 PF12781.7 EDN07320.1 - 0.16 11.1 0.7 0.27 10.3 0.7 1.3 1 0 0 1 1 1 0 ATP-binding dynein motor region ZZ PF00569.17 EDN07320.1 - 2.4 8.0 6.6 21 5.0 6.6 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type BCMA-Tall_bind PF09257.10 EDN07321.1 - 0.08 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 BCMA, TALL-1 binding PGAP1 PF07819.13 EDN07322.1 - 3.6e-86 288.6 0.0 6.2e-86 287.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein ResIII PF04851.15 EDN07322.1 - 5.2e-20 72.1 0.0 9.9e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDN07322.1 - 2.3e-13 50.5 0.0 1.1e-12 48.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN07322.1 - 1.2e-07 31.7 0.0 2.3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Abhydrolase_6 PF12697.7 EDN07322.1 - 0.00022 21.9 0.1 0.00065 20.4 0.1 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EDN07322.1 - 0.00093 19.1 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EDN07322.1 - 0.0031 17.2 0.0 0.0081 15.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 EDN07322.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EDN07322.1 - 0.016 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EDN07322.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 COesterase PF00135.28 EDN07322.1 - 0.18 10.6 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family NAD_binding_10 PF13460.6 EDN07323.1 - 3.4e-08 33.6 0.0 7.6e-08 32.5 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDN07323.1 - 0.0014 18.3 0.0 0.0036 16.9 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EDN07323.1 - 0.075 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Cu-oxidase_2 PF07731.14 EDN07325.1 - 3.4e-32 111.1 6.8 4.6e-30 104.1 0.2 3.6 3 2 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EDN07325.1 - 2.4e-30 105.7 0.2 2.4e-30 105.7 0.2 2.7 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDN07325.1 - 2.4e-26 92.1 7.9 8.1e-26 90.4 3.6 2.9 2 1 0 2 2 2 1 Multicopper oxidase Myofilin PF15929.5 EDN07327.1 - 0.016 15.6 0.7 0.017 15.5 0.7 1.1 1 0 0 1 1 1 0 Myofilin WD40 PF00400.32 EDN07329.1 - 2.3e-42 142.1 22.8 1.9e-08 34.8 1.1 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 EDN07329.1 - 2.7e-14 52.8 0.4 5.5e-14 51.8 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN07329.1 - 7.7e-11 41.6 0.2 1.7e-10 40.5 0.2 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EDN07329.1 - 7.9e-10 38.0 13.4 0.12 11.0 0.1 5.9 3 3 3 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDN07329.1 - 3.8e-07 30.3 0.1 0.018 15.3 0.0 4.4 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EDN07329.1 - 0.00013 21.8 0.3 0.00096 19.0 0.0 2.5 3 0 0 3 3 3 1 F-box PRANC PF09372.10 EDN07329.1 - 0.15 12.4 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 PRANC domain APG17 PF04108.12 EDN07330.1 - 1.1e-134 449.5 0.2 1.3e-134 449.3 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 RasGAP_C PF03836.15 EDN07330.1 - 0.1 12.7 2.0 18 5.5 0.4 2.8 2 1 0 2 2 2 0 RasGAP C-terminus DUF4472 PF14739.6 EDN07330.1 - 0.12 13.1 2.9 0.39 11.5 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) DUF4358 PF14270.6 EDN07330.1 - 0.13 12.5 0.6 0.43 10.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Tweety PF04906.13 EDN07330.1 - 0.2 10.3 4.5 0.18 10.5 0.6 2.4 3 0 0 3 3 3 0 Tweety Fib_alpha PF08702.10 EDN07330.1 - 0.21 11.8 1.3 12 6.1 0.0 2.9 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family FRP PF18032.1 EDN07330.1 - 0.48 11.1 4.4 10 6.8 0.2 3.1 3 0 0 3 3 3 0 Photoprotection regulator fluorescence recovery protein DUF1664 PF07889.12 EDN07330.1 - 0.53 10.3 5.2 47 4.0 0.1 4.0 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) RIO1 PF01163.22 EDN07331.1 - 2.4e-73 245.8 0.0 2.4e-73 245.8 0.0 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EDN07331.1 - 0.0005 20.1 0.3 0.079 12.9 0.0 2.7 2 1 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN07331.1 - 0.0059 16.0 0.6 2.1 7.6 0.0 2.8 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pept_tRNA_hydro PF01195.19 EDN07331.1 - 0.035 14.1 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase DUF3410 PF11890.8 EDN07331.1 - 0.14 12.0 1.0 0.44 10.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) SMC_N PF02463.19 EDN07332.1 - 1.3e-50 171.9 59.7 3.8e-49 167.1 59.7 3.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDN07332.1 - 3.1e-29 101.7 2.3 1e-28 100.0 0.1 2.9 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDN07332.1 - 4.8e-17 62.7 12.6 4.4e-11 43.2 0.1 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDN07332.1 - 8e-14 52.1 55.9 1.7e-08 34.6 23.7 4.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 EDN07332.1 - 8.6e-05 23.1 48.6 8.6e-05 23.1 48.6 6.7 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.6 EDN07332.1 - 0.006 16.3 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rota_NSP4 PF01452.16 EDN07332.1 - 0.034 13.8 4.8 0.18 11.4 4.8 2.3 1 0 0 1 1 1 0 Rotavirus non structural protein ABC_tran PF00005.27 EDN07332.1 - 0.57 10.7 0.0 0.57 10.7 0.0 6.1 3 2 1 4 4 4 0 ABC transporter HsbA PF12296.8 EDN07332.1 - 5.2 7.5 11.6 8 6.9 1.4 4.5 4 0 0 4 4 4 0 Hydrophobic surface binding protein A DUF3605 PF12239.8 EDN07333.1 - 2.2e-50 170.9 2.8 3.4e-37 128.1 0.7 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3605) IL32 PF15225.6 EDN07333.1 - 0.15 12.4 0.7 0.3 11.5 0.2 1.7 1 1 1 2 2 2 0 Interleukin 32 FAD_binding_6 PF00970.24 EDN07334.1 - 7.4e-33 112.9 0.0 1.1e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EDN07334.1 - 3.4e-28 98.5 0.0 5.3e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EDN07334.1 - 1.1e-05 25.6 0.0 0.001 19.2 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EDN07334.1 - 0.027 14.7 0.0 0.061 13.5 0.0 1.6 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF639 PF04842.12 EDN07334.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) DUF4176 PF13780.6 EDN07334.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) tRNA-synt_1d PF00750.19 EDN07335.1 - 4.5e-98 328.4 8.2 1.2e-96 323.7 8.2 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 EDN07335.1 - 0.00022 21.8 0.1 0.0012 19.4 0.0 2.4 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain Spc29 PF17082.5 EDN07335.1 - 0.02 14.8 0.5 0.037 13.9 0.5 1.4 1 0 0 1 1 1 0 Spindle Pole Component 29 AAA_3 PF07726.11 EDN07335.1 - 0.051 13.4 0.0 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF4795 PF16043.5 EDN07335.1 - 0.31 10.6 5.6 0.17 11.5 2.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) SelP_N PF04592.14 EDN07338.1 - 1.1 8.6 7.5 1.8 7.9 7.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RRM_1 PF00076.22 EDN07339.1 - 0.0025 17.6 0.0 0.014 15.2 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RR_TM4-6 PF06459.12 EDN07339.1 - 9 6.0 13.0 11 5.7 0.7 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5104 PF17117.5 EDN07341.1 - 0.095 13.1 0.1 0.15 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5104) DEAD PF00270.29 EDN07343.1 - 3.2e-42 144.3 0.3 6.4e-42 143.3 0.3 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN07343.1 - 1.1e-30 106.2 0.2 1e-29 103.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07343.1 - 1.6e-05 25.0 0.0 3.8e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PBP1_TM PF14812.6 EDN07343.1 - 1.1 9.7 8.4 3.5 8.1 8.4 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Acyltransferase PF01553.21 EDN07345.1 - 2.2e-05 24.1 0.0 3.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase L31 PF09784.9 EDN07348.1 - 1.8e-46 156.8 0.9 2e-46 156.6 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Annexin PF00191.20 EDN07349.1 - 2.7e-60 200.3 3.2 6.5e-18 64.6 0.0 4.2 4 0 0 4 4 4 4 Annexin Glyco_transf_7C PF02709.14 EDN07349.1 - 0.0062 16.2 0.4 0.012 15.3 0.4 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Acetyltransf_11 PF13720.6 EDN07349.1 - 0.21 12.1 0.7 9.4 6.8 0.0 3.1 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 EBP PF05241.12 EDN07350.1 - 5e-65 218.3 5.0 6.6e-65 217.9 5.0 1.1 1 0 0 1 1 1 1 Emopamil binding protein MIG-14_Wnt-bd PF06664.12 EDN07350.1 - 0.0028 16.9 0.3 0.005 16.1 0.3 1.5 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion tRNA-synt_1d PF00750.19 EDN07351.1 - 7.5e-73 245.5 0.9 7.8e-61 205.9 0.3 2.3 1 1 1 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.15 EDN07351.1 - 2.1e-18 66.6 0.4 1.7e-17 63.7 0.4 2.4 1 1 0 1 1 1 1 DALR anticodon binding domain BCNT PF07572.12 EDN07351.1 - 0.032 14.3 0.6 0.071 13.2 0.6 1.5 1 0 0 1 1 1 0 Bucentaur or craniofacial development SH3_9 PF14604.6 EDN07352.1 - 0.00081 19.2 0.2 0.00081 19.2 0.2 2.3 2 0 0 2 2 2 1 Variant SH3 domain ZZ PF00569.17 EDN07352.1 - 0.0015 18.3 5.7 0.0015 18.3 5.7 2.4 2 0 0 2 2 2 1 Zinc finger, ZZ type SH3_2 PF07653.17 EDN07352.1 - 0.035 13.8 0.0 0.035 13.8 0.0 2.2 3 0 0 3 3 3 0 Variant SH3 domain CBM_21 PF03370.13 EDN07353.1 - 2e-34 118.1 2.9 3.2e-34 117.5 2.9 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EDN07353.1 - 1.9e-08 34.8 3.4 3.5e-08 33.9 3.4 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) CENP-T_C PF15511.6 EDN07354.1 - 4.4e-09 36.4 0.1 5.3e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EDN07354.1 - 1.9e-05 25.1 0.2 2.2e-05 24.8 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EDN07354.1 - 5e-05 23.4 0.2 7.3e-05 22.9 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EDN07354.1 - 0.00012 22.3 0.1 0.00021 21.5 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EDN07354.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EDN07354.1 - 0.0038 17.3 0.0 0.0045 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDN07354.1 - 0.0045 17.0 0.0 0.0054 16.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated UPF0137 PF03677.13 EDN07354.1 - 0.05 13.4 0.2 0.061 13.1 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TFIID_20kDa PF03847.13 EDN07354.1 - 0.059 13.9 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A HIGH_NTase1_ass PF16581.5 EDN07354.1 - 0.073 13.1 0.0 0.082 12.9 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Mito_carr PF00153.27 EDN07355.1 - 2.7e-44 149.0 1.7 4.5e-15 55.3 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Glutaredoxin PF00462.24 EDN07356.1 - 4.7e-15 55.5 0.0 4.1e-14 52.5 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin CRIM PF16978.5 EDN07357.1 - 1.2e-41 142.1 0.0 2.8e-41 140.9 0.0 1.6 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EDN07357.1 - 4.2e-29 101.0 0.5 7.1e-29 100.3 0.5 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 EDN07357.1 - 0.047 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 TUG ubiquitin-like domain Pkinase PF00069.25 EDN07358.1 - 1.7e-68 230.8 0.0 2.3e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07358.1 - 4.2e-34 118.0 0.0 5.9e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN07358.1 - 1.7e-07 30.9 0.0 2.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TMEM154 PF15102.6 EDN07358.1 - 0.04 13.8 1.3 0.066 13.1 1.3 1.2 1 0 0 1 1 1 0 TMEM154 protein family EssA PF10661.9 EDN07358.1 - 0.081 12.8 0.6 0.13 12.1 0.6 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA DUF2615 PF11027.8 EDN07358.1 - 0.12 12.5 0.3 0.48 10.6 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) Rad21_Rec8 PF04824.16 EDN07358.1 - 0.12 11.6 0.1 0.27 10.5 0.1 1.5 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein zf-Tim10_DDP PF02953.15 EDN07359.1 - 9.3e-22 76.5 0.4 1.2e-21 76.1 0.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Ins_beta PF03488.14 EDN07359.1 - 0.067 13.2 0.3 0.12 12.4 0.3 1.3 1 0 0 1 1 1 0 Nematode insulin-related peptide beta type DUF4603 PF15376.6 EDN07359.1 - 0.22 8.9 5.5 0.27 8.6 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Lectin_leg-like PF03388.13 EDN07360.1 - 2.8e-64 216.6 0.0 3.6e-64 216.3 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EDN07360.1 - 2.8e-08 34.0 0.2 3.9e-08 33.5 0.2 1.2 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EDN07360.1 - 0.00011 21.8 0.0 0.014 14.9 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain ATG27 PF09451.10 EDN07360.1 - 0.17 11.7 0.1 0.26 11.1 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 Borrelia_P83 PF05262.11 EDN07361.1 - 0.23 9.9 18.2 0.32 9.4 18.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Asp-B-Hydro_N PF05279.11 EDN07361.1 - 7.7 6.5 16.4 13 5.8 16.4 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CENP-Q PF13094.6 EDN07362.1 - 0.0054 17.0 13.4 0.0093 16.2 9.3 2.8 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Choline_kinase PF01633.20 EDN07362.1 - 0.014 15.0 0.0 0.036 13.7 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EDN07362.1 - 0.02 14.5 0.0 0.06 12.9 0.0 1.7 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN07362.1 - 0.04 13.8 0.4 0.04 13.8 0.4 3.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDN07362.1 - 0.1 11.9 0.0 0.27 10.5 0.0 1.7 1 0 0 1 1 1 0 Protein kinase domain CDC45 PF02724.14 EDN07362.1 - 7.2 4.8 8.5 12 4.0 8.5 1.4 1 0 0 1 1 1 0 CDC45-like protein Beta-lactamase PF00144.24 EDN07365.1 - 1.8e-24 86.6 0.0 3.6e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase PRCC PF10253.9 EDN07366.1 - 2.2e-34 120.2 2.2 2.2e-34 120.2 2.2 2.1 2 0 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting AAA_5 PF07728.14 EDN07367.1 - 1.2e-126 417.2 0.1 1.2e-21 77.2 0.0 9.7 8 1 1 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EDN07367.1 - 5.2e-48 161.6 3.3 9.7e-17 61.1 0.0 5.3 4 0 0 4 4 4 3 Midasin AAA lid domain AAA PF00004.29 EDN07367.1 - 3.8e-33 114.7 0.7 1.4e-05 25.5 0.1 7.4 7 0 0 7 7 6 6 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDN07367.1 - 7.4e-30 103.8 3.2 2.8e-06 27.0 0.1 7.4 7 0 0 7 7 7 5 P-loop containing dynein motor region AAA_3 PF07726.11 EDN07367.1 - 1.6e-28 99.2 0.0 1.8e-10 40.8 0.0 7.4 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EDN07367.1 - 1e-27 96.3 0.6 1.9e-26 92.2 0.0 3.5 4 0 0 4 4 2 1 Midasin AAA lid domain AAA_16 PF13191.6 EDN07367.1 - 4.4e-24 85.8 9.4 0.00088 19.7 0.1 8.1 6 2 0 6 6 6 6 AAA ATPase domain Dynein_heavy PF03028.15 EDN07367.1 - 5.1e-19 68.5 0.0 4.2e-05 23.6 0.0 7.3 6 0 0 6 6 6 4 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 EDN07367.1 - 1e-18 67.4 0.0 0.0017 17.4 0.0 7.9 8 1 0 8 8 8 4 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EDN07367.1 - 1.8e-17 63.9 1.3 0.029 14.7 0.0 7.5 6 0 0 6 6 6 4 AAA domain ABC_tran PF00005.27 EDN07367.1 - 1.8e-16 60.9 4.8 0.0053 17.3 0.0 7.0 6 0 0 6 6 6 3 ABC transporter Sigma54_activat PF00158.26 EDN07367.1 - 7.4e-16 58.3 0.0 0.0079 15.9 0.0 6.4 6 0 0 6 6 6 3 Sigma-54 interaction domain AAA_14 PF13173.6 EDN07367.1 - 9.9e-16 58.0 0.0 0.015 15.3 0.0 7.3 7 0 0 7 7 6 3 AAA domain TsaE PF02367.17 EDN07367.1 - 2.1e-15 56.8 4.3 0.19 11.7 0.0 6.7 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDN07367.1 - 2.6e-15 57.1 5.2 0.1 13.2 0.1 7.3 7 0 0 7 7 6 3 AAA domain AAA_33 PF13671.6 EDN07367.1 - 4.3e-15 56.1 0.0 0.1 12.8 0.0 7.0 6 0 0 6 6 6 2 AAA domain AAA_30 PF13604.6 EDN07367.1 - 1.1e-12 48.1 0.0 0.8 9.4 0.0 7.0 6 1 0 6 6 6 2 AAA domain Mg_chelatase PF01078.21 EDN07367.1 - 3.5e-12 46.1 1.6 2.1 7.7 0.0 8.5 9 0 0 9 9 9 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EDN07367.1 - 4e-12 46.4 9.7 0.071 13.0 0.0 6.5 6 0 0 6 6 5 3 NACHT domain Zeta_toxin PF06414.12 EDN07367.1 - 2.4e-11 43.3 0.5 1.8 7.8 0.0 7.7 7 0 0 7 7 7 1 Zeta toxin RuvB_N PF05496.12 EDN07367.1 - 3.8e-11 43.0 3.6 0.6 9.8 0.0 6.9 7 0 0 7 7 6 2 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 EDN07367.1 - 8.2e-11 42.2 1.9 0.0055 16.8 0.0 6.4 6 0 0 6 6 6 2 Sigma-54 interaction domain SRP54 PF00448.22 EDN07367.1 - 4.3e-10 39.6 4.2 0.79 9.3 0.0 6.0 6 0 0 6 6 6 2 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 EDN07367.1 - 2.2e-09 37.5 3.0 0.21 11.5 0.1 5.9 5 0 0 5 5 5 2 RsgA GTPase DUF815 PF05673.13 EDN07367.1 - 2.7e-09 36.6 2.1 0.3 10.2 0.1 5.9 6 0 0 6 6 6 2 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EDN07367.1 - 4.8e-09 36.6 6.4 6.2 7.3 0.0 7.6 7 0 0 7 7 7 0 RNA helicase Rad17 PF03215.15 EDN07367.1 - 1.2e-08 35.1 0.9 0.52 10.2 0.0 5.6 5 0 0 5 5 5 1 Rad17 P-loop domain AAA_19 PF13245.6 EDN07367.1 - 1.8e-08 34.9 2.2 5.6 7.3 0.1 6.2 6 0 0 6 6 5 0 AAA domain AAA_29 PF13555.6 EDN07367.1 - 3.9e-08 32.9 4.8 6.5 6.6 0.0 6.5 6 0 0 6 6 6 0 P-loop containing region of AAA domain T2SSE PF00437.20 EDN07367.1 - 2e-07 30.4 3.2 0.42 9.6 0.0 6.0 6 0 0 6 6 6 1 Type II/IV secretion system protein PduV-EutP PF10662.9 EDN07367.1 - 4.3e-07 29.8 6.9 0.32 10.7 0.0 6.3 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 EDN07367.1 - 5.5e-07 29.8 3.0 18 5.6 0.0 6.4 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EDN07367.1 - 9.2e-07 28.6 7.0 1.5 8.4 0.1 6.2 6 0 0 6 6 6 2 AAA domain CbiA PF01656.23 EDN07367.1 - 9.8e-07 28.9 0.4 0.16 12.0 0.0 4.3 3 0 0 3 3 3 2 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 EDN07367.1 - 2.7e-06 27.2 0.4 1.3 8.7 0.0 5.6 6 0 0 6 6 6 1 IstB-like ATP binding protein Bac_DnaA PF00308.18 EDN07367.1 - 5.5e-06 26.4 0.4 4.7 7.0 0.0 4.7 4 0 0 4 4 4 0 Bacterial dnaA protein TniB PF05621.11 EDN07367.1 - 9.1e-06 25.2 0.3 4.7 6.6 0.0 5.5 6 0 0 6 6 5 0 Bacterial TniB protein ATPase_2 PF01637.18 EDN07367.1 - 9.8e-06 25.6 0.0 15 5.4 0.0 6.1 6 0 0 6 6 6 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EDN07367.1 - 1.1e-05 25.2 0.4 13 5.5 0.0 5.7 6 0 0 6 6 6 0 AAA domain AAA_28 PF13521.6 EDN07367.1 - 1.3e-05 25.6 11.9 0.48 10.7 0.6 6.0 6 0 0 6 6 5 2 AAA domain ResIII PF04851.15 EDN07367.1 - 7.4e-05 22.8 0.7 2.6 8.0 0.0 4.8 5 0 0 5 5 3 1 Type III restriction enzyme, res subunit AAA_8 PF12780.7 EDN07367.1 - 0.00015 21.2 6.8 1.3 8.3 0.1 5.6 5 1 0 5 5 5 1 P-loop containing dynein motor region D4 MCM PF00493.23 EDN07367.1 - 0.00018 20.7 0.1 1.8 7.6 0.0 5.1 6 0 0 6 6 5 1 MCM P-loop domain CPT PF07931.12 EDN07367.1 - 0.00048 20.0 2.8 1 9.2 0.0 5.4 6 1 0 6 6 4 1 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 EDN07367.1 - 0.00056 19.2 1.7 43 3.2 0.1 5.4 5 0 0 5 5 5 0 NB-ARC domain TIP49 PF06068.13 EDN07367.1 - 0.00069 18.9 2.3 3.4 6.8 0.0 4.8 5 0 0 5 5 5 0 TIP49 P-loop domain Viral_helicase1 PF01443.18 EDN07367.1 - 0.0007 19.4 3.6 1.7 8.3 0.3 5.2 5 1 0 5 5 5 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EDN07367.1 - 0.00083 18.9 1.4 8.6 5.8 0.0 5.1 6 0 0 6 6 4 0 PhoH-like protein G-alpha PF00503.20 EDN07367.1 - 0.00086 18.6 4.0 1.9 7.6 0.0 5.5 6 0 0 6 6 6 1 G-protein alpha subunit AAA_17 PF13207.6 EDN07367.1 - 0.00098 19.6 2.9 24 5.3 0.1 4.6 4 0 0 4 4 4 0 AAA domain ATP_bind_1 PF03029.17 EDN07367.1 - 0.001 18.9 8.8 23 4.7 0.1 6.4 7 0 0 7 7 6 0 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EDN07367.1 - 0.0011 18.5 6.1 9.5 5.6 0.1 5.6 6 0 0 6 6 5 0 Signal recognition particle receptor beta subunit cobW PF02492.19 EDN07367.1 - 0.0017 18.0 4.7 13 5.3 0.1 4.9 5 0 0 5 5 5 0 CobW/HypB/UreG, nucleotide-binding domain ATPase PF06745.13 EDN07367.1 - 0.0061 15.9 0.4 17 4.7 0.0 4.9 6 0 0 6 6 5 0 KaiC NTPase_1 PF03266.15 EDN07367.1 - 0.0093 15.9 9.8 2.1 8.3 0.1 5.4 5 0 0 5 5 5 1 NTPase MMR_HSR1 PF01926.23 EDN07367.1 - 0.016 15.3 4.4 44 4.2 0.0 6.0 6 0 0 6 6 6 0 50S ribosome-binding GTPase SKI PF01202.22 EDN07367.1 - 0.025 14.7 0.3 21 5.2 0.0 4.6 4 0 0 4 4 4 0 Shikimate kinase PRK PF00485.18 EDN07367.1 - 0.056 13.2 0.1 13 5.5 0.0 4.1 5 0 0 5 5 4 0 Phosphoribulokinase / Uridine kinase family KTI12 PF08433.10 EDN07367.1 - 0.086 12.3 0.5 24 4.3 0.0 3.8 4 0 0 4 4 2 0 Chromatin associated protein KTI12 tRNA_lig_kinase PF08303.11 EDN07367.1 - 0.089 12.9 0.7 21 5.2 0.1 3.4 3 0 0 3 3 2 0 tRNA ligase kinase domain FtsK_SpoIIIE PF01580.18 EDN07367.1 - 0.37 10.1 2.1 23 4.2 0.0 4.1 5 0 0 5 5 5 0 FtsK/SpoIIIE family Rad51 PF08423.11 EDN07367.1 - 0.72 9.1 2.2 13 5.0 0.1 3.5 4 0 0 4 4 3 0 Rad51 MobB PF03205.14 EDN07367.1 - 1.4 8.8 11.2 16 5.4 0.3 5.4 6 0 0 6 6 5 0 Molybdopterin guanine dinucleotide synthesis protein B dNK PF01712.19 EDN07367.1 - 4.4 7.1 9.5 23 4.8 0.0 5.1 7 0 0 7 7 4 0 Deoxynucleoside kinase Voltage_CLC PF00654.20 EDN07368.1 - 1.9e-72 244.5 25.7 1.9e-72 244.5 25.7 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EDN07368.1 - 4.6e-05 23.8 0.0 0.03 14.7 0.0 3.0 2 1 0 2 2 2 2 CBS domain P5CR_dimer PF14748.6 EDN07369.1 - 1.7e-33 114.9 3.7 3.2e-33 114.1 3.7 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EDN07369.1 - 1.4e-10 41.6 0.0 3.2e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent CTK3 PF12243.8 EDN07370.1 - 4.7e-51 171.9 0.2 6.7e-51 171.4 0.2 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EDN07370.1 - 6.4e-22 77.5 9.4 6.4e-22 77.5 9.4 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus DUF3873 PF12989.7 EDN07370.1 - 0.045 14.1 0.2 0.13 12.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) WW_FCH_linker PF16623.5 EDN07371.1 - 4.4 8.1 10.3 0.93 10.3 3.0 2.6 1 1 0 2 2 2 0 Unstructured linker region between on GAS7 protein DUF155 PF02582.14 EDN07372.1 - 3.6e-51 173.8 0.1 5.7e-51 173.1 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 WD40 PF00400.32 EDN07374.1 - 3.9e-28 97.1 16.7 1.1e-06 29.3 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.7 EDN07374.1 - 8e-11 41.7 0.4 1.5e-10 40.8 0.4 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EDN07374.1 - 4.3e-08 33.3 0.2 0.049 13.9 0.0 5.2 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDN07374.1 - 3.7e-05 23.2 0.0 0.0011 18.4 0.0 2.5 2 1 1 3 3 3 1 WD40-like domain F-box PF00646.33 EDN07374.1 - 0.00022 21.0 0.7 0.00044 20.1 0.7 1.5 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EDN07374.1 - 0.00036 19.3 3.7 1.7 7.2 0.0 4.4 2 1 3 5 5 5 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EDN07374.1 - 0.00043 19.3 1.0 1.4 7.7 0.2 3.3 2 1 1 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Zip PF02535.22 EDN07375.1 - 4.5e-32 111.6 8.9 1.8e-29 103.0 8.9 3.1 1 1 0 1 1 1 1 ZIP Zinc transporter Hat1_N PF10394.9 EDN07376.1 - 1.1e-51 175.2 0.1 1.7e-51 174.6 0.1 1.3 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus LSM PF01423.22 EDN07378.1 - 1.8e-18 66.0 0.0 2.4e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDN07378.1 - 0.0023 18.1 0.0 0.0036 17.4 0.0 1.5 1 1 0 1 1 1 1 Ataxin 2 SM domain API5 PF05918.11 EDN07378.1 - 7.3 5.3 7.8 9 5.0 7.8 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DSPc PF00782.20 EDN07379.1 - 8e-10 38.6 0.0 1.4e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDN07379.1 - 0.0051 16.4 0.0 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EDN07379.1 - 0.022 14.7 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PPR_2 PF13041.6 EDN07380.1 - 7.9e-15 54.8 1.6 0.018 15.2 0.0 7.3 5 2 3 8 8 8 4 PPR repeat family PPR PF01535.20 EDN07380.1 - 3.9e-11 42.4 9.0 0.13 12.6 0.1 7.7 8 1 0 8 8 8 3 PPR repeat PPR_3 PF13812.6 EDN07380.1 - 3.6e-07 30.2 0.0 0.0073 16.4 0.0 4.8 4 2 1 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EDN07380.1 - 7.7e-05 22.2 0.0 0.25 10.7 0.8 2.8 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EDN07380.1 - 0.063 13.0 0.6 40 4.0 0.1 4.2 5 0 0 5 5 5 0 PPR repeat PLA2_B PF01735.18 EDN07381.1 - 2.1e-24 85.8 0.0 1.1e-23 83.5 0.0 2.0 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Exo70 PF03081.15 EDN07382.1 - 3.6e-84 283.0 0.0 1.7e-83 280.7 0.0 1.8 2 0 0 2 2 2 1 Exo70 exocyst complex subunit DASH_Dam1 PF08653.10 EDN07382.1 - 0.08 12.8 1.5 28 4.6 0.0 4.3 4 0 0 4 4 4 0 DASH complex subunit Dam1 TraF_2 PF13729.6 EDN07382.1 - 0.12 11.8 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein CYYR1 PF10873.8 EDN07383.1 - 6.4e-06 26.7 5.8 6.4e-06 26.7 5.8 3.3 3 1 1 4 4 4 2 Cysteine and tyrosine-rich protein 1 Podoplanin PF05808.11 EDN07383.1 - 0.0012 18.9 0.4 0.002 18.3 0.4 1.2 1 0 0 1 1 1 1 Podoplanin DUF4690 PF15756.5 EDN07383.1 - 0.12 12.9 0.1 0.32 11.6 0.1 1.6 1 0 0 1 1 1 0 Small Novel Rich in Cartilage BCDHK_Adom3 PF10436.9 EDN07384.1 - 7.7e-72 240.4 0.0 1.2e-71 239.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDN07384.1 - 8e-13 48.9 0.0 2.2e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDN07384.1 - 0.056 13.3 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MFS_1 PF07690.16 EDN07385.1 - 1.4e-23 83.4 38.8 1.4e-23 83.4 38.8 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Methyltransf_2 PF00891.18 EDN07386.1 - 6.3e-25 87.7 0.0 8.4e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EDN07386.1 - 0.044 13.6 0.0 0.23 11.3 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain TrmB PF01978.19 EDN07386.1 - 0.16 11.9 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB 2CSK_N PF08521.10 EDN07387.1 - 0.057 13.5 0.1 0.47 10.6 0.1 2.2 2 0 0 2 2 2 0 Two-component sensor kinase N-terminal SKN1 PF03935.15 EDN07388.1 - 8.7e-207 687.5 0.0 1.1e-206 687.1 0.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Fructosamin_kin PF03881.14 EDN07391.1 - 7.8e-56 189.4 0.0 1e-55 189.0 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EDN07391.1 - 3.6e-05 23.8 0.0 4.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN07391.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Ribosomal_S24e PF01282.19 EDN07391.1 - 0.19 11.7 0.0 1 9.3 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S24e Ribosomal_L3 PF00297.22 EDN07392.1 - 1.3e-160 534.4 10.6 1.5e-160 534.2 10.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 YqgF PF14639.6 EDN07393.1 - 0.1 12.4 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 DUF3435 PF11917.8 EDN07394.1 - 1.3e-166 554.7 0.1 1.3e-166 554.7 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) DEAD PF00270.29 EDN07396.1 - 2.1e-09 37.4 0.0 4.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN07396.1 - 4.9e-05 23.4 0.0 0.00012 22.1 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN07396.1 - 0.03 14.6 0.2 0.13 12.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain Pkinase_fungal PF17667.1 EDN07397.1 - 1.5e-146 488.4 0.0 1.9e-146 488.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN07397.1 - 5.5e-07 29.2 0.0 1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN07397.1 - 0.0017 18.4 0.0 0.038 13.9 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EDN07397.1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase F-box-like PF12937.7 EDN07398.1 - 0.0015 18.4 0.9 0.0026 17.6 0.9 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN07398.1 - 0.074 13.0 0.7 0.13 12.2 0.7 1.3 1 0 0 1 1 1 0 F-box domain TPR_1 PF00515.28 EDN07400.1 - 1.2e-50 167.3 24.2 6.4e-08 32.1 0.1 11.0 11 1 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 EDN07400.1 - 5.7e-46 151.0 18.3 2.4e-06 27.2 0.0 10.7 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07400.1 - 2.3e-37 124.1 16.6 2.6e-07 30.3 0.0 10.7 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07400.1 - 3.8e-29 101.1 1.5 1.4e-05 25.7 0.0 6.6 5 1 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 EDN07400.1 - 7.6e-26 88.6 16.4 0.0008 19.6 0.2 10.1 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDN07400.1 - 1.5e-24 84.6 6.4 3.9e-05 24.1 0.0 8.7 5 2 5 10 10 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 EDN07400.1 - 4.8e-24 83.8 22.8 4.9e-05 22.9 1.5 9.7 6 2 3 9 9 9 6 TPR repeat TPR_19 PF14559.6 EDN07400.1 - 1.2e-23 83.4 11.1 0.00044 20.7 0.0 7.2 5 2 3 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDN07400.1 - 7.6e-20 71.0 22.1 0.00016 21.9 0.8 7.9 3 2 5 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 EDN07400.1 - 1.8e-19 68.2 13.4 0.034 14.2 0.1 9.8 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_6 PF13174.6 EDN07400.1 - 1.1e-17 63.4 19.1 0.0011 19.5 0.0 9.7 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_9 PF13371.6 EDN07400.1 - 1.3e-13 50.8 10.9 0.006 16.7 0.2 7.0 3 2 5 8 8 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN07400.1 - 8.1e-12 45.2 10.3 7.9e-08 32.4 2.6 3.7 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EDN07400.1 - 8e-10 38.4 9.0 0.013 14.7 0.2 5.3 1 1 4 5 5 5 3 Tetratricopeptide repeat BTAD PF03704.17 EDN07400.1 - 4.4e-06 27.2 5.2 0.15 12.5 0.0 3.6 3 0 0 3 3 3 3 Bacterial transcriptional activator domain TPR_21 PF09976.9 EDN07400.1 - 0.0026 17.5 15.1 0.053 13.2 0.0 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat-like domain DUF2225 PF09986.9 EDN07400.1 - 0.018 14.8 3.3 0.62 9.7 0.0 3.0 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 EDN07400.1 - 0.092 13.1 2.5 3 8.3 0.1 3.9 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDN07400.1 - 0.31 11.0 15.6 24 5.0 0.1 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat SNAP PF14938.6 EDN07400.1 - 2.5 7.4 13.1 42 3.4 0.2 4.5 1 1 2 4 4 4 0 Soluble NSF attachment protein, SNAP NUC173 PF08161.12 EDN07402.1 - 1.5e-81 273.0 0.1 9.1e-80 267.1 0.2 2.9 2 0 0 2 2 2 1 NUC173 domain HEAT_2 PF13646.6 EDN07402.1 - 0.04 14.3 1.2 0.49 10.8 0.1 3.5 2 0 0 2 2 2 0 HEAT repeats Stork_head PF10264.9 EDN07402.1 - 0.18 12.0 0.2 1.2 9.3 0.0 2.6 3 0 0 3 3 3 0 Winged helix Storkhead-box1 domain MMS19_C PF12460.8 EDN07402.1 - 1.1 8.4 15.1 1 8.4 1.6 3.9 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal LSM PF01423.22 EDN07403.1 - 0.0094 15.6 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 LSM domain ArsB PF02040.15 EDN07406.1 - 1.5e-09 37.7 19.5 4.5e-05 23.0 7.7 2.2 2 0 0 2 2 2 2 Arsenical pump membrane protein CENP-B_dimeris PF09026.10 EDN07406.1 - 9.5 6.7 8.8 7.6 7.0 5.5 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ribonuclease_3 PF00636.26 EDN07407.1 - 1.5e-38 131.6 0.1 2.3e-19 69.9 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDN07407.1 - 3.8e-22 78.8 0.1 1.2e-11 44.8 0.1 3.7 3 1 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EDN07407.1 - 7.5e-22 77.3 0.0 2e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Dicer dimerisation domain DEAD PF00270.29 EDN07407.1 - 4e-16 59.3 0.0 1.1e-15 57.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN07407.1 - 9.6e-14 51.7 0.1 2.9e-13 50.1 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07407.1 - 1.2e-08 35.2 0.2 5e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Proteasome PF00227.26 EDN07408.1 - 1e-56 191.5 0.0 1.2e-32 112.9 0.0 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EDN07408.1 - 9.2e-11 41.2 0.1 3.1e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Peptidase_S13 PF02113.15 EDN07408.1 - 0.058 12.1 0.1 0.84 8.3 0.0 2.0 2 0 0 2 2 2 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family RINGv PF12906.7 EDN07409.1 - 4.1e-09 36.4 4.3 9.1e-09 35.3 1.4 2.4 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 EDN07409.1 - 0.0013 18.8 4.5 0.62 10.2 1.7 2.3 2 0 0 2 2 2 2 PHD-finger zf-RanBP PF00641.18 EDN07409.1 - 0.048 13.0 0.1 0.11 11.8 0.1 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zf-BED PF02892.15 EDN07409.1 - 0.23 11.5 0.2 0.23 11.5 0.2 1.9 2 0 0 2 2 2 0 BED zinc finger zf-RING_2 PF13639.6 EDN07409.1 - 0.4 11.0 4.5 2.2 8.7 1.3 2.3 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.29 EDN07409.1 - 4.7 7.2 7.0 1.3 8.9 3.2 1.9 2 0 0 2 2 2 0 PHD-finger Aldo_ket_red PF00248.21 EDN07410.1 - 8.4e-41 140.1 0.0 1.1e-40 139.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Fungal_trans PF04082.18 EDN07411.1 - 4.6e-07 29.1 1.5 6.8e-07 28.6 0.4 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN07411.1 - 7e-05 22.9 10.1 0.00012 22.1 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EDN07412.1 - 3.3e-34 118.3 67.7 1.8e-29 102.8 45.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDN07412.1 - 0.001 18.1 24.6 0.0039 16.1 11.0 2.8 1 1 2 3 3 3 3 MFS_1 like family Zn_clus PF00172.18 EDN07413.1 - 1.3e-07 31.6 10.0 3e-07 30.5 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDN07413.1 - 0.0052 15.9 0.1 0.012 14.7 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain CDC45 PF02724.14 EDN07413.1 - 3.7 5.7 6.6 5.8 5.1 6.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Sugar_tr PF00083.24 EDN07414.1 - 5.5e-91 305.7 29.1 6.8e-91 305.4 29.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN07414.1 - 4.3e-10 39.0 49.2 1.3e-07 30.9 21.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily RVT_2 PF07727.14 EDN07415.1 - 0.0064 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) APH PF01636.23 EDN07416.1 - 9.3e-09 35.6 0.0 5.5e-08 33.0 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family KNOX2 PF03791.13 EDN07416.1 - 0.0083 15.6 0.3 0.021 14.3 0.3 1.6 1 0 0 1 1 1 1 KNOX2 domain Pkinase PF00069.25 EDN07417.1 - 3.5e-05 23.3 0.0 4.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN07417.1 - 4.7e-05 22.8 0.0 6.6e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDN07417.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EDN07417.1 - 0.053 13.1 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase AbiEii PF08843.11 EDN07418.1 - 0.0067 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system APH PF01636.23 EDN07419.1 - 7e-09 36.0 0.0 9.3e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family YaeQ PF07152.12 EDN07420.1 - 0.14 11.8 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 YaeQ protein XhlA PF10779.9 EDN07421.1 - 0.0072 16.5 0.4 0.016 15.4 0.4 1.6 1 0 0 1 1 1 1 Haemolysin XhlA KLRAQ PF10205.9 EDN07421.1 - 0.013 15.7 0.2 0.02 15.1 0.2 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF1664 PF07889.12 EDN07421.1 - 0.013 15.5 1.7 0.034 14.2 1.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) UPF0184 PF03670.13 EDN07421.1 - 0.016 15.6 6.3 0.29 11.5 2.1 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0184) DASH_Spc19 PF08287.11 EDN07421.1 - 0.018 15.0 0.2 0.023 14.6 0.2 1.3 1 0 0 1 1 1 0 Spc19 Exonuc_VII_L PF02601.15 EDN07421.1 - 0.018 14.6 1.3 0.023 14.3 1.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.7 EDN07421.1 - 0.019 15.1 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Tropomyosin like Snapin_Pallidin PF14712.6 EDN07421.1 - 0.029 14.8 1.4 0.079 13.4 0.6 1.9 1 1 1 2 2 2 0 Snapin/Pallidin CLZ PF16526.5 EDN07421.1 - 0.032 14.6 0.9 0.082 13.3 0.9 1.8 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Seryl_tRNA_N PF02403.22 EDN07421.1 - 0.038 14.2 0.9 0.59 10.4 0.0 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 EDN07421.1 - 0.039 12.8 0.1 0.052 12.4 0.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Sipho_Gp157 PF05565.11 EDN07421.1 - 0.047 13.7 0.4 0.068 13.2 0.4 1.2 1 0 0 1 1 1 0 Siphovirus Gp157 DUF4763 PF15960.5 EDN07421.1 - 0.057 12.7 3.0 0.047 13.0 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) ABC_tran_CTD PF16326.5 EDN07421.1 - 0.058 13.6 0.2 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain BLOC1_2 PF10046.9 EDN07421.1 - 0.063 13.6 0.3 0.21 11.9 0.2 2.1 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 EDN07421.1 - 0.063 12.6 0.1 0.085 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 EDN07421.1 - 0.075 11.0 2.0 0.088 10.8 2.0 1.1 1 0 0 1 1 1 0 Prominin DUF3552 PF12072.8 EDN07421.1 - 0.076 12.4 0.2 0.11 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) MscS_porin PF12795.7 EDN07421.1 - 0.081 12.5 3.3 0.13 11.7 3.3 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF2730 PF10805.8 EDN07421.1 - 0.087 12.9 2.0 0.12 12.5 0.5 1.9 2 1 0 2 2 1 0 Protein of unknown function (DUF2730) Nsp1_C PF05064.13 EDN07421.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Nsp1-like C-terminal region YvrJ PF12841.7 EDN07421.1 - 0.12 12.0 0.0 1.4 8.5 0.0 2.5 1 1 1 2 2 2 0 YvrJ protein family MerR-DNA-bind PF09278.11 EDN07421.1 - 0.14 12.7 4.4 0.49 11.0 3.4 2.2 1 1 1 2 2 2 0 MerR, DNA binding DASH_Dam1 PF08653.10 EDN07421.1 - 0.16 11.8 3.2 6.7 6.6 1.1 3.6 3 1 1 4 4 4 0 DASH complex subunit Dam1 NPV_P10 PF05531.12 EDN07421.1 - 0.17 12.4 3.1 1.3 9.6 2.9 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.6 EDN07421.1 - 0.19 10.3 0.4 0.22 10.2 0.4 1.1 1 0 0 1 1 1 0 AAA domain DUF4164 PF13747.6 EDN07421.1 - 0.24 11.7 4.3 0.61 10.4 4.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) TRPM_tetra PF16519.5 EDN07421.1 - 0.38 10.9 4.4 7.4 6.7 0.2 2.8 1 1 1 2 2 2 0 Tetramerisation domain of TRPM STAT_alpha PF01017.20 EDN07421.1 - 1.3 8.9 5.8 5.1 7.0 4.6 2.3 1 1 0 1 1 1 0 STAT protein, all-alpha domain Mst1_SARAH PF11629.8 EDN07421.1 - 2.3 8.4 6.0 4.2 7.5 1.9 2.7 1 1 1 2 2 2 0 C terminal SARAH domain of Mst1 Vps39_1 PF10366.9 EDN07422.1 - 2.6e-30 104.9 0.0 9.5e-29 99.9 0.0 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 EDN07422.1 - 5.6e-20 72.1 0.0 1.8e-19 70.4 0.0 1.8 1 1 0 1 1 1 1 CNH domain Vps39_2 PF10367.9 EDN07422.1 - 5.9e-12 46.0 0.0 1.6e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EDN07422.1 - 1.4e-07 31.5 0.0 3.8e-06 26.8 0.0 2.6 2 0 0 2 2 2 1 Region in Clathrin and VPS 6PF2K PF01591.18 EDN07423.1 - 8.6e-70 234.5 0.0 1.2e-69 234.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDN07423.1 - 7.7e-40 136.7 0.0 1.2e-39 136.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDN07423.1 - 2e-06 28.1 0.0 3.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDN07423.1 - 0.0016 17.9 0.0 0.0053 16.2 0.0 1.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 RVT_1 PF00078.27 EDN07425.1 - 7.1e-27 94.4 0.0 1.3e-26 93.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN07425.1 - 0.064 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease TBCC_N PF16752.5 EDN07425.1 - 1.2 9.6 5.7 0.99 9.9 0.3 2.7 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain TFIIE_beta PF02186.15 EDN07427.1 - 0.13 12.6 1.6 1.9 8.9 0.0 2.8 3 0 0 3 3 3 0 TFIIE beta subunit core domain zf-C2H2_10 PF16588.5 EDN07427.1 - 0.24 11.2 3.7 0.47 10.2 3.7 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC PF00098.23 EDN07427.1 - 0.92 9.7 6.1 1.6 9.0 6.1 1.3 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH PF17917.1 EDN07428.1 - 5.2e-37 126.3 0.0 1.3e-36 125.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN07428.1 - 2.9e-32 110.7 0.0 6.9e-32 109.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN07428.1 - 6.9e-32 110.7 0.0 1.2e-31 109.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN07428.1 - 1.3e-18 66.9 2.2 1.9e-18 66.3 0.4 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EDN07428.1 - 4.6e-12 46.2 0.0 1.6e-11 44.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN07428.1 - 0.0062 16.7 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger RVP_2 PF08284.11 EDN07428.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF2759 PF10958.8 EDN07429.1 - 0.063 13.0 0.3 0.17 11.6 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) FAD_binding_4 PF01565.23 EDN07430.1 - 5.4e-24 84.5 2.1 8.3e-24 83.9 2.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF3435 PF11917.8 EDN07431.1 - 3.2e-140 467.8 4.5 2.6e-125 418.6 0.5 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN07431.1 - 0.00062 19.6 1.3 0.0029 17.4 0.0 2.4 3 0 0 3 3 3 1 Phage integrase family HbrB PF08539.11 EDN07432.1 - 6.3e-51 172.7 0.0 1.6e-50 171.4 0.0 1.7 1 0 0 1 1 1 1 HbrB-like Myb_DNA-bind_6 PF13921.6 EDN07433.1 - 1.3e-07 31.8 0.5 1.5e-06 28.3 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 EDN07433.1 - 0.062 14.3 0.1 0.54 11.3 0.0 2.1 1 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain AAA PF00004.29 EDN07434.1 - 2.3e-16 60.4 0.0 7.3e-16 58.8 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDN07434.1 - 0.00024 21.1 0.0 0.00074 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN07434.1 - 0.0011 19.2 0.7 0.011 16.0 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDN07434.1 - 0.01 16.2 2.1 0.011 16.2 0.1 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 EDN07434.1 - 0.013 15.8 1.2 0.035 14.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EDN07434.1 - 0.019 14.7 1.9 0.022 14.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDN07434.1 - 0.03 14.5 2.1 0.1 12.8 0.1 2.8 2 2 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EDN07434.1 - 0.033 14.0 0.0 0.033 14.0 0.0 3.7 3 1 1 4 4 4 0 AAA domain CCDC24 PF15669.5 EDN07435.1 - 2.5 7.9 8.5 2.9 7.7 8.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family SR-25 PF10500.9 EDN07435.1 - 5.8 6.5 42.0 14 5.2 42.0 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Helo_like_N PF17111.5 EDN07436.1 - 7.9e-10 38.5 6.6 8.2e-10 38.4 1.6 2.2 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins Myc-LZ PF02344.15 EDN07436.1 - 0.027 14.5 2.1 0.091 12.9 2.1 1.9 1 0 0 1 1 1 0 Myc leucine zipper domain Syntaxin PF00804.25 EDN07436.1 - 0.057 13.1 3.5 0.091 12.4 3.1 1.5 1 1 0 1 1 1 0 Syntaxin Takusan PF04822.13 EDN07436.1 - 0.065 13.1 0.9 0.42 10.5 0.3 2.2 1 1 1 2 2 2 0 Takusan HWE_HK PF07536.14 EDN07436.1 - 0.11 13.3 1.6 0.23 12.2 0.6 2.0 1 1 1 2 2 2 0 HWE histidine kinase Pkinase_fungal PF17667.1 EDN07437.1 - 6e-67 226.2 2.3 2.7e-45 154.9 0.2 2.1 2 0 0 2 2 2 2 Fungal protein kinase DUF4263 PF14082.6 EDN07437.1 - 0.022 15.0 0.2 0.14 12.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4263) Ldh_1_C PF02866.18 EDN07438.1 - 2.1e-48 164.4 0.0 1.2e-47 162.0 0.0 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDN07438.1 - 3.5e-43 147.1 0.0 6.9e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDN07438.1 - 0.0006 18.9 0.0 0.00085 18.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EDN07438.1 - 0.064 12.6 0.1 0.68 9.2 0.0 2.5 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.16 EDN07438.1 - 0.14 11.7 0.1 1.7 8.1 0.1 2.4 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase V-SNARE_C PF12352.8 EDN07439.1 - 1.9e-09 37.7 0.2 4.5e-09 36.4 0.2 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Rho_N PF07498.12 EDN07439.1 - 0.11 12.4 0.3 7.5 6.6 0.0 2.8 3 0 0 3 3 3 0 Rho termination factor, N-terminal domain DUF5353 PF17304.2 EDN07440.1 - 6.9e-33 112.2 1.9 9.3e-33 111.8 1.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5353) Herpes_UL56 PF04534.12 EDN07440.1 - 0.018 14.5 1.9 0.021 14.3 1.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL56 protein DUF2537 PF10801.8 EDN07440.1 - 0.027 14.7 0.7 0.038 14.2 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2537) 2-oxoacid_dh PF00198.23 EDN07441.1 - 8e-75 251.3 0.3 1.1e-74 250.8 0.3 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDN07441.1 - 1.4e-16 60.0 0.9 1.4e-16 60.0 0.9 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 EDN07441.1 - 1.4e-13 50.9 0.8 3.5e-13 49.6 0.3 2.1 2 0 0 2 2 2 1 e3 binding domain DUF421 PF04239.12 EDN07441.1 - 0.013 15.2 0.2 0.033 13.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF421) Sec7 PF01369.20 EDN07442.1 - 1.8e-70 236.4 0.5 6.2e-70 234.6 0.5 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EDN07442.1 - 2.2e-43 147.9 6.8 2.2e-43 147.9 6.8 3.0 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EDN07442.1 - 1.1e-32 111.7 3.8 1.1e-30 105.3 0.0 4.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) DCB PF16213.5 EDN07442.1 - 2.2e-17 63.3 2.7 1.5e-15 57.3 0.0 3.3 3 0 0 3 3 3 2 Dimerisation and cyclophilin-binding domain of Mon2 DUF1908 PF08926.11 EDN07442.1 - 0.043 12.9 2.5 0.88 8.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1908) NAD_binding_7 PF13241.6 EDN07443.1 - 5.7e-31 107.0 0.1 8.5e-31 106.5 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EDN07443.1 - 1.1e-28 98.6 0.0 1.7e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EDN07443.1 - 1.3e-15 56.5 0.1 2.7e-15 55.5 0.1 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 EDN07443.1 - 0.00077 18.8 0.1 0.0011 18.4 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase LSDAT_prok PF18171.1 EDN07443.1 - 0.0015 17.8 0.1 0.0022 17.2 0.1 1.2 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote TrkA_N PF02254.18 EDN07443.1 - 0.031 14.5 0.1 0.065 13.5 0.1 1.5 1 1 0 1 1 1 0 TrkA-N domain Pribosyltran_N PF13793.6 EDN07444.1 - 1.3e-31 108.9 0.0 1.4e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EDN07445.1 - 5.9e-34 117.7 0.0 3.3e-29 102.2 0.0 2.4 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EDN07445.1 - 1.8e-10 40.5 0.0 4.8e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl transferase domain RVT_1 PF00078.27 EDN07447.1 - 2.5e-33 115.5 0.0 3.9e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN07447.1 - 7.2e-12 45.7 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 RNase H Pkinase PF00069.25 EDN07449.1 - 7.6e-16 58.3 0.0 5.3e-11 42.4 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07449.1 - 7.2e-08 32.0 0.0 7.1e-06 25.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Vta1 PF04652.16 EDN07450.1 - 0.033 14.2 0.1 0.058 13.4 0.0 1.5 2 0 0 2 2 2 0 Vta1 like RVT_1 PF00078.27 EDN07452.1 - 1.3e-33 116.4 0.0 2.2e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN07452.1 - 1.1e-11 45.0 0.0 2.7e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN07452.1 - 3.2e-10 39.9 0.0 1e-09 38.3 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN07452.1 - 0.18 12.2 0.8 0.75 10.3 0.6 2.1 2 0 0 2 2 2 0 ORF 12 gene product N-terminal p450 PF00067.22 EDN07453.1 - 5.2e-62 210.1 0.1 6.7e-62 209.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_10 PF05971.12 EDN07454.1 - 4.7e-05 22.9 0.2 5e-05 22.8 0.2 1.0 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_10 PF05971.12 EDN07455.1 - 5e-23 81.9 0.0 6.2e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EDN07455.1 - 0.072 12.6 0.0 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Complex1_LYR PF05347.15 EDN07456.1 - 5e-05 23.3 1.7 8.1e-05 22.6 0.7 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Ank_4 PF13637.6 EDN07457.1 - 2e-11 44.1 0.8 6.4e-09 36.2 0.1 3.6 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDN07457.1 - 0.00011 22.8 0.3 0.038 14.6 0.2 2.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN07457.1 - 0.0022 18.4 2.0 0.25 12.0 0.1 3.8 4 1 0 4 4 3 1 Ankyrin repeat KilA-N PF04383.13 EDN07457.1 - 0.0038 17.1 0.4 0.027 14.3 0.4 2.3 1 1 0 1 1 1 1 KilA-N domain Tuberculin PF12198.8 EDN07457.1 - 0.031 14.4 0.6 0.13 12.4 0.6 2.1 1 0 0 1 1 1 0 Theoretical tuberculin protein PhaP_Bmeg PF09602.10 EDN07457.1 - 0.048 13.6 5.2 0.081 12.8 4.0 2.0 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Snf7 PF03357.21 EDN07457.1 - 0.078 12.6 2.4 0.18 11.4 2.4 1.5 1 0 0 1 1 1 0 Snf7 Prominin PF05478.11 EDN07457.1 - 0.099 10.6 1.7 0.15 10.0 1.7 1.1 1 0 0 1 1 1 0 Prominin PhoU PF01895.19 EDN07457.1 - 0.15 12.5 0.9 0.45 11.0 0.9 1.9 1 0 0 1 1 1 0 PhoU domain Spore_III_AB PF09548.10 EDN07457.1 - 0.17 12.0 5.5 0.54 10.4 5.5 1.9 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Phage_GPO PF05929.11 EDN07457.1 - 0.18 11.4 2.4 0.31 10.6 2.4 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Phage_GP20 PF06810.11 EDN07457.1 - 0.35 10.7 6.5 0.15 11.9 3.3 2.0 2 1 0 2 2 2 0 Phage minor structural protein GP20 Ank PF00023.30 EDN07457.1 - 1.3 9.6 4.9 85 3.9 0.1 4.1 3 0 0 3 3 3 0 Ankyrin repeat Exonuc_VII_L PF02601.15 EDN07457.1 - 1.3 8.5 6.3 0.18 11.4 1.4 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit Rick_17kDa_Anti PF05433.15 EDN07458.1 - 4.2e-05 23.3 19.2 7.8e-05 22.5 19.2 1.5 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EDN07458.1 - 0.023 14.7 16.1 0.066 13.2 16.1 1.8 1 0 0 1 1 1 0 Glycine zipper DUF755 PF05501.11 EDN07458.1 - 0.22 11.8 19.0 0.29 11.4 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF533 PF04391.12 EDN07458.1 - 0.48 10.0 2.9 0.85 9.2 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF533) PT-VENN PF04829.13 EDN07458.1 - 7 6.8 13.0 16 5.7 13.0 1.5 1 1 0 1 1 1 0 Pre-toxin domain with VENN motif DUF1275 PF06912.11 EDN07459.1 - 3e-35 121.9 6.9 3.4e-35 121.7 6.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) AzlC PF03591.14 EDN07459.1 - 0.09 13.2 5.9 0.16 12.5 1.4 2.5 2 1 0 2 2 2 0 AzlC protein AzlD PF05437.12 EDN07459.1 - 3.6 7.8 10.7 2.4 8.4 1.1 3.1 1 1 1 3 3 3 0 Branched-chain amino acid transport protein (AzlD) Oxidored_q6 PF01058.22 EDN07460.1 - 4.5e-21 75.1 0.0 6.6e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Pkinase PF00069.25 EDN07461.1 - 1.1e-14 54.4 0.0 4.8e-14 52.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07461.1 - 9.3e-07 28.4 0.0 0.00017 21.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase ABC_tran PF00005.27 EDN07462.1 - 1.6e-46 158.3 0.0 1.5e-23 83.8 0.0 3.5 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 EDN07462.1 - 3e-30 104.1 0.4 1e-29 102.4 0.4 2.0 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 EDN07462.1 - 1.1e-16 61.5 1.9 0.0026 17.6 0.1 4.9 4 1 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDN07462.1 - 1.3e-15 57.4 0.0 1.6e-05 24.5 0.0 3.7 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDN07462.1 - 3.2e-10 40.8 0.4 0.0006 20.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EDN07462.1 - 1.2e-08 34.5 0.1 0.0041 16.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN07462.1 - 3.5e-07 30.3 0.0 0.0016 18.4 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDN07462.1 - 1.5e-06 28.2 0.0 0.0066 16.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 EDN07462.1 - 4.4e-06 27.0 0.0 0.017 15.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDN07462.1 - 5.1e-06 27.1 0.1 0.17 12.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDN07462.1 - 8.2e-06 26.1 0.0 0.1 12.9 0.0 3.4 4 0 0 4 4 2 2 AAA domain AAA_16 PF13191.6 EDN07462.1 - 1.1e-05 25.8 0.2 0.43 10.9 0.0 3.7 4 0 0 4 4 4 2 AAA ATPase domain PduV-EutP PF10662.9 EDN07462.1 - 2.8e-05 23.9 0.0 0.065 13.0 0.0 3.0 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 EDN07462.1 - 4.9e-05 22.4 0.1 0.17 10.8 0.0 2.6 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EDN07462.1 - 6.2e-05 23.4 0.0 0.55 10.7 0.0 4.0 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EDN07462.1 - 6.2e-05 23.2 0.0 0.22 11.6 0.0 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain NACHT PF05729.12 EDN07462.1 - 0.0001 22.3 0.0 0.081 12.8 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 EDN07462.1 - 0.00013 21.9 0.6 1.1 8.9 0.0 3.5 3 1 0 3 3 3 2 AAA ATPase domain Dynamin_N PF00350.23 EDN07462.1 - 0.00015 21.9 0.9 0.0036 17.4 0.0 3.0 3 1 0 3 3 2 1 Dynamin family RNA_helicase PF00910.22 EDN07462.1 - 0.00016 22.0 0.0 0.71 10.3 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_27 PF13514.6 EDN07462.1 - 0.00044 19.9 0.0 0.24 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDN07462.1 - 0.0011 19.0 0.0 2.7 8.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EDN07462.1 - 0.0011 19.1 0.0 1.4 9.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDN07462.1 - 0.0016 18.2 0.0 1.8 8.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain G-alpha PF00503.20 EDN07462.1 - 0.0016 17.7 0.0 1.8 7.6 0.0 2.5 2 0 0 2 2 2 2 G-protein alpha subunit NB-ARC PF00931.22 EDN07462.1 - 0.0023 17.1 0.0 0.18 11.0 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 EDN07462.1 - 0.0029 17.4 0.0 2 8.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EDN07462.1 - 0.0079 15.8 0.1 6.6 6.3 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EDN07462.1 - 0.0086 15.5 0.7 9.3 5.5 0.0 3.2 3 0 0 3 3 3 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 EDN07462.1 - 0.0087 15.9 0.0 4.1 7.1 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SbcCD_C PF13558.6 EDN07462.1 - 0.0097 16.1 0.0 1.6 9.1 0.0 3.0 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Roc PF08477.13 EDN07462.1 - 0.013 15.7 0.0 8.4 6.6 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EDN07462.1 - 0.015 15.2 0.1 3.4 7.5 0.0 3.1 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea ATP-synt_ab PF00006.25 EDN07462.1 - 0.021 14.5 0.0 7.3 6.2 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain IstB_IS21 PF01695.17 EDN07462.1 - 0.022 14.5 0.0 11 5.7 0.0 2.9 3 0 0 3 3 2 0 IstB-like ATP binding protein CLP1_P PF16575.5 EDN07462.1 - 0.026 14.3 0.1 1.4 8.7 0.0 2.7 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ParcG PF10274.9 EDN07462.1 - 0.026 14.6 1.5 0.34 11.0 0.2 2.7 1 1 2 3 3 3 0 Parkin co-regulated protein Ploopntkinase3 PF18751.1 EDN07462.1 - 0.038 13.9 0.0 5.8 6.8 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 EDN07462.1 - 0.045 13.3 0.0 6.2 6.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MukB PF04310.12 EDN07462.1 - 0.046 13.5 0.1 9.6 5.9 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal Cytidylate_kin PF02224.18 EDN07462.1 - 0.051 13.3 0.0 7.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase Rad17 PF03215.15 EDN07462.1 - 0.056 13.4 0.0 3.6 7.5 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain Septin PF00735.18 EDN07462.1 - 0.057 12.7 0.1 5.2 6.3 0.0 3.0 3 0 0 3 3 3 0 Septin T2SSE PF00437.20 EDN07462.1 - 0.066 12.3 0.1 3.9 6.5 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 EDN07462.1 - 0.069 12.7 0.0 7.2 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN07462.1 - 0.097 12.7 0.0 21 5.1 0.0 3.3 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EDN07462.1 - 0.1 11.7 0.0 11 5.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EDN07462.1 - 0.12 11.8 0.4 7 6.0 0.0 3.0 4 0 0 4 4 2 0 Magnesium chelatase, subunit ChlI AAA_13 PF13166.6 EDN07462.1 - 0.27 9.9 4.5 2.7 6.5 0.0 3.0 4 0 0 4 4 3 0 AAA domain TPR_11 PF13414.6 EDN07465.1 - 1.3e-09 37.6 2.6 2.2e-05 24.0 0.0 3.7 2 1 1 3 3 3 3 TPR repeat TPR_1 PF00515.28 EDN07465.1 - 2.8e-08 33.3 7.1 3.6e-05 23.4 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDN07465.1 - 1e-05 25.5 1.4 0.29 11.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN07465.1 - 2.4e-05 24.1 17.8 6.3e-05 22.8 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07465.1 - 0.00038 20.4 10.8 0.00095 19.2 0.0 4.3 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDN07465.1 - 0.00092 19.3 0.4 0.75 10.0 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDN07465.1 - 0.0011 18.9 4.2 0.018 15.0 0.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07465.1 - 0.012 16.2 9.9 0.2 12.3 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDN07465.1 - 0.024 14.9 0.8 0.024 14.9 0.8 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN07465.1 - 0.072 14.0 0.3 0.072 14.0 0.3 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDN07465.1 - 0.083 13.4 2.7 0.68 10.5 0.1 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EDN07465.1 - 0.15 11.5 0.7 0.42 10.1 0.1 2.0 2 0 0 2 2 2 0 SHNi-TPR SIMPL PF04402.14 EDN07466.1 - 1.7e-26 93.9 2.0 1.9e-26 93.7 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Acyltransferase PF01553.21 EDN07467.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase DUF3099 PF11298.8 EDN07467.1 - 0.26 11.4 3.1 0.97 9.6 3.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) Lipase_3 PF01764.25 EDN07468.1 - 1.1e-21 77.2 0.0 1.9e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) ILVD_EDD PF00920.21 EDN07469.1 - 3e-210 699.3 0.8 3.5e-210 699.0 0.8 1.0 1 0 0 1 1 1 1 Dehydratase family 5_nucleotid_C PF02872.18 EDN07469.1 - 0.031 14.5 0.3 0.2 11.9 0.0 2.4 3 0 0 3 3 3 0 5'-nucleotidase, C-terminal domain DDE_1 PF03184.19 EDN07471.1 - 6.2e-33 113.9 0.0 1.1e-32 113.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07471.1 - 1.1e-10 41.3 0.0 2.3e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN07471.1 - 2.2e-06 27.3 0.1 5.6e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN07471.1 - 1.2e-05 25.1 0.0 0.00059 19.6 0.0 2.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_28 PF13518.6 EDN07471.1 - 0.079 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Pkinase PF00069.25 EDN07472.1 - 8.3e-26 90.9 0.0 2e-11 43.8 0.0 3.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07472.1 - 3.7e-13 49.4 0.0 2.7e-09 36.7 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase DUF3666 PF12408.8 EDN07473.1 - 0.038 13.2 0.1 0.21 10.9 0.1 2.1 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase WHAMM-JMY_N PF15920.5 EDN07473.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 N-terminal of Junction-mediating and WASP homolog-associated Tim17 PF02466.19 EDN07474.1 - 6.4e-27 94.1 2.2 9.4e-27 93.6 2.2 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DDE_1 PF03184.19 EDN07475.1 - 1.4e-31 109.5 0.0 3e-31 108.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07475.1 - 8.1e-06 25.8 0.0 2.3e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN07475.1 - 9.2e-05 22.2 0.1 0.004 16.9 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease PhrC_PhrF PF11131.8 EDN07476.1 - 0.077 12.6 0.6 0.14 11.8 0.6 1.3 1 0 0 1 1 1 0 Rap-phr extracellular signalling DUF2428 PF10350.9 EDN07477.1 - 1.8e-54 184.8 0.0 4.6e-54 183.5 0.0 1.7 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) IBN_N PF03810.19 EDN07477.1 - 0.12 12.3 0.1 1.1 9.2 0.0 2.7 2 0 0 2 2 2 0 Importin-beta N-terminal domain PX PF00787.24 EDN07478.1 - 1.7e-18 66.7 0.0 6e-18 64.9 0.0 2.0 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EDN07478.1 - 6.6e-07 29.1 9.0 0.0017 17.9 0.8 2.1 2 0 0 2 2 2 2 Vps5 C terminal like Peptidase_C10 PF01640.17 EDN07478.1 - 0.068 13.5 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase C10 family HTH_8 PF02954.19 EDN07478.1 - 0.097 12.5 0.1 0.72 9.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family SPX PF03105.19 EDN07478.1 - 8.1 6.2 13.9 14 5.5 7.5 2.4 2 1 0 2 2 2 0 SPX domain UCH PF00443.29 EDN07479.1 - 2e-73 247.1 0.0 2.9e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EDN07479.1 - 8.1e-13 48.8 0.0 3.3e-12 46.9 0.0 2.1 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 EDN07479.1 - 1.2e-08 35.0 0.0 0.012 15.3 0.0 3.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EDN07479.1 - 0.0084 15.8 0.0 0.18 11.5 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal Sugar_tr PF00083.24 EDN07480.1 - 5.9e-76 256.1 20.7 8.5e-76 255.6 20.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN07480.1 - 8.2e-10 38.1 19.9 8.2e-10 38.1 19.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SYS1 PF09801.9 EDN07480.1 - 0.0088 16.2 1.3 0.022 14.9 0.1 2.2 2 0 0 2 2 2 1 Integral membrane protein S linking to the trans Golgi network Abhydrolase_6 PF12697.7 EDN07482.1 - 0.0076 16.9 0.0 0.0088 16.7 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Kinesin PF00225.23 EDN07483.1 - 2.3e-103 345.6 0.9 2.3e-103 345.6 0.9 2.1 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDN07483.1 - 3.6e-60 202.2 0.0 3.6e-60 202.2 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding PHA_gran_rgn PF09650.10 EDN07483.1 - 0.046 14.0 0.8 0.24 11.7 0.5 2.4 2 1 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) T3SSipB PF16535.5 EDN07483.1 - 0.11 13.0 0.3 0.11 13.0 0.3 3.4 2 1 0 2 2 2 0 Type III cell invasion protein SipB AAA_16 PF13191.6 EDN07483.1 - 0.22 11.9 0.0 0.22 11.9 0.0 3.4 2 2 0 2 2 2 0 AAA ATPase domain CAP59_mtransfer PF11735.8 EDN07483.1 - 9.2 5.9 9.3 1.7 8.3 4.6 2.0 1 1 1 2 2 2 0 Cryptococcal mannosyltransferase 1 DUF1899 PF08953.11 EDN07484.1 - 3.5e-34 116.5 0.1 6.8e-34 115.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EDN07484.1 - 1.8e-21 75.7 0.2 3.3e-21 74.9 0.2 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EDN07484.1 - 1.2e-11 44.9 1.1 0.0012 19.6 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07484.1 - 0.0013 19.0 0.0 0.0046 17.2 0.0 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain SlyX PF04102.12 EDN07484.1 - 0.13 12.9 1.1 0.3 11.7 1.1 1.6 1 0 0 1 1 1 0 SlyX Spc7 PF08317.11 EDN07484.1 - 0.16 10.8 0.1 0.22 10.4 0.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FliT PF05400.13 EDN07484.1 - 0.18 12.7 0.0 0.33 11.8 0.0 1.4 1 0 0 1 1 1 0 Flagellar protein FliT zf-C3HC4_3 PF13920.6 EDN07486.1 - 0.025 14.5 15.5 0.047 13.5 15.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EDN07486.1 - 1.5 8.8 7.9 2.8 7.9 7.9 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein CBFD_NFYB_HMF PF00808.23 EDN07487.1 - 1.7e-14 53.9 2.9 2.5e-14 53.3 2.9 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDN07487.1 - 5e-06 26.9 0.1 9e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RAI16-like PF10257.9 EDN07488.1 - 7.8e-91 304.6 0.0 1e-90 304.2 0.0 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein DUF4746 PF15928.5 EDN07489.1 - 0.19 11.1 8.3 0.39 10.1 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ATP-synt_E PF05680.12 EDN07489.1 - 3.6 8.0 6.2 1 9.7 1.8 2.2 2 0 0 2 2 2 0 ATP synthase E chain DUF573 PF04504.14 EDN07491.1 - 1.1e-05 26.0 0.1 3.4e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN07491.1 - 0.00012 22.2 0.1 0.00026 21.1 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN07491.1 - 0.013 15.8 0.2 0.033 14.4 0.2 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN07491.1 - 0.047 14.1 2.3 0.48 10.8 2.3 2.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain OrsD PF12013.8 EDN07492.1 - 1.3e-13 51.4 0.4 1.3e-13 51.4 0.4 3.3 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DNA_primase_S PF01896.19 EDN07492.1 - 1.3 9.0 4.9 0.75 9.8 0.2 2.6 1 1 1 2 2 2 0 DNA primase small subunit OrsD PF12013.8 EDN07493.1 - 4.5e-38 130.2 5.5 4.5e-38 130.2 5.5 2.2 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN07493.1 - 0.0099 15.6 3.5 0.17 11.6 1.5 2.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain DUF4298 PF14131.6 EDN07493.1 - 0.096 12.7 3.9 2.8 8.0 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) DUF4363 PF14276.6 EDN07493.1 - 1.3 9.2 5.1 1.8 8.7 0.6 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) OrsD PF12013.8 EDN07494.1 - 3.6e-19 69.3 1.1 1.3e-18 67.5 0.1 2.2 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D DUF5484 PF17583.2 EDN07495.1 - 9.5 6.0 13.1 50 3.7 0.2 4.8 4 1 1 5 5 5 0 Family of unknown function (DUF5484) APH PF01636.23 EDN07496.1 - 6.2e-14 52.5 0.1 9.3e-14 51.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN07496.1 - 0.15 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase DDE_1 PF03184.19 EDN07497.1 - 1.4e-31 109.5 0.0 3e-31 108.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07497.1 - 8.2e-06 25.8 0.0 2.3e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN07497.1 - 9.3e-05 22.2 0.1 0.004 16.9 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease NUDE_C PF04880.13 EDN07497.1 - 0.31 11.5 2.4 0.54 10.7 2.4 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DDE_1 PF03184.19 EDN07498.1 - 9.5e-23 80.7 0.0 1.8e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN07498.1 - 0.00012 21.9 0.0 0.00031 20.5 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07498.1 - 0.00086 19.3 0.0 0.0032 17.5 0.0 2.0 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN07498.1 - 0.0081 15.9 0.5 0.016 15.0 0.5 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN07498.1 - 0.023 14.2 0.0 0.063 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) DDE_Tnp_1_7 PF13843.6 EDN07499.1 - 1.2e-13 51.1 0.0 7.5e-12 45.2 0.0 2.0 1 1 1 2 2 2 2 Transposase IS4 Inovirus_Gp2 PF11726.8 EDN07499.1 - 0.062 13.3 0.0 0.073 13.0 0.0 1.1 1 0 0 1 1 1 0 Inovirus Gp2 DUF573 PF04504.14 EDN07503.1 - 1.1e-05 26.0 0.1 3.4e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN07503.1 - 0.00012 22.2 0.1 0.00026 21.1 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN07503.1 - 0.013 15.8 0.2 0.033 14.4 0.2 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN07503.1 - 0.047 14.1 2.3 0.48 10.8 2.3 2.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain RVT_1 PF00078.27 EDN07504.1 - 1.1e-21 77.4 0.0 1.6e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SCAN PF02023.17 EDN07506.1 - 0.067 13.0 1.7 0.13 12.1 1.7 1.4 1 0 0 1 1 1 0 SCAN domain DUF3435 PF11917.8 EDN07509.1 - 2e-20 73.1 0.0 3e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-Di19 PF05605.12 EDN07509.1 - 0.016 15.5 2.1 0.12 12.7 0.6 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Adeno_hexon_C PF03678.14 EDN07509.1 - 0.024 14.1 0.0 0.055 12.9 0.0 1.5 1 1 0 1 1 1 0 Hexon, adenovirus major coat protein, C-terminal domain zf-C2H2_4 PF13894.6 EDN07509.1 - 0.14 13.1 2.3 2.1 9.4 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN07509.1 - 0.19 12.2 2.1 4.6 7.9 0.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type POX PF07526.11 EDN07510.1 - 0.0035 17.9 0.4 0.0044 17.6 0.4 1.1 1 0 0 1 1 1 1 Associated with HOX CDC45 PF02724.14 EDN07510.1 - 0.081 11.2 7.0 0.089 11.1 7.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 EDN07510.1 - 0.79 8.2 8.8 0.91 8.0 8.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SURF2 PF05477.11 EDN07510.1 - 1.4 8.6 6.2 1.6 8.4 6.2 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SDA1 PF05285.12 EDN07510.1 - 1.5 8.2 9.8 1.6 8.1 9.8 1.1 1 0 0 1 1 1 0 SDA1 YL1 PF05764.13 EDN07510.1 - 9 6.3 11.6 13 5.8 11.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 EDN07510.1 - 9.5 5.4 11.3 11 5.2 11.3 1.1 1 0 0 1 1 1 0 BUD22 DUF2244 PF10003.9 EDN07512.1 - 0.086 12.5 3.5 1.7 8.3 0.2 3.0 2 1 1 3 3 3 0 Integral membrane protein (DUF2244) Ste5 PF11610.8 EDN07512.1 - 0.088 12.7 8.6 3.4 7.6 0.1 5.2 5 0 0 5 5 5 0 Scaffold protein Ste5, Fus3-binding region NPF PF16601.5 EDN07513.1 - 0.037 14.5 0.2 0.037 14.5 0.2 1.1 1 0 0 1 1 1 0 Rabosyn-5 repeating NPF sequence-motif REV1_C PF16727.5 EDN07514.1 - 0.051 14.0 0.8 0.098 13.1 0.1 1.8 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain OrsD PF12013.8 EDN07516.1 - 1.8e-37 128.3 5.2 1.8e-37 128.3 5.2 2.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN07516.1 - 0.025 14.3 3.5 0.29 10.9 1.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF913 PF06025.12 EDN07516.1 - 0.61 9.0 8.3 0.31 10.0 1.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Pox_RNA_Pol_19 PF05320.12 EDN07516.1 - 2.7 7.9 8.7 5.4 7.0 5.1 2.2 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit CPSF100_C PF13299.6 EDN07516.1 - 2.9 8.0 10.1 0.25 11.5 2.7 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 EDN07516.1 - 4.5 7.0 6.8 1.5 8.5 1.3 2.3 2 0 0 2 2 2 0 Connexin FAM60A PF15396.6 EDN07516.1 - 6.1 6.8 10.3 1.6 8.6 0.9 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF1840 PF08895.11 EDN07516.1 - 7.3 7.0 8.9 15 5.9 3.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) OrsD PF12013.8 EDN07519.1 - 0.00077 19.9 0.0 0.00086 19.7 0.0 1.1 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D APG5 PF04106.12 EDN07520.1 - 0.15 11.7 0.2 0.31 10.6 0.0 1.5 2 0 0 2 2 2 0 Autophagy protein Apg5 E7 PF00527.18 EDN07520.1 - 1.8 8.8 9.9 0.97 9.7 2.4 2.4 2 0 0 2 2 2 0 E7 protein, Early protein OrsD PF12013.8 EDN07525.1 - 2.5e-19 69.8 0.1 7.3e-19 68.3 0.0 1.7 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D rve PF00665.26 EDN07526.1 - 1.2e-12 48.0 0.1 3e-12 46.8 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN07526.1 - 0.015 15.0 3.0 0.032 14.0 3.0 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN07526.1 - 0.018 14.9 0.0 0.046 13.6 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN07526.1 - 0.067 13.0 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN07526.1 - 0.18 11.5 0.1 0.37 10.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) NDUFA12 PF05071.16 EDN07526.1 - 0.26 12.1 0.2 0.26 12.1 0.2 3.0 3 0 0 3 3 3 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Phage_min_cap2 PF06152.11 EDN07526.1 - 0.38 9.6 1.5 0.63 8.9 1.5 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 Mito_fiss_reg PF05308.11 EDN07526.1 - 7.7 6.5 12.3 0.45 10.5 6.1 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator OrsD PF12013.8 EDN07528.1 - 1.6e-05 25.3 3.0 1.6e-05 25.3 3.0 3.2 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D OrsD PF12013.8 EDN07529.1 - 2.3e-10 40.9 0.9 7.1e-10 39.3 0.9 1.9 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EDN07529.1 - 5.4e-10 39.3 0.0 2.4e-09 37.2 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase FOXP-CC PF16159.5 EDN07529.1 - 0.0021 18.6 1.8 0.074 13.7 0.2 2.7 2 0 0 2 2 2 1 FOXP coiled-coil domain T4SS-DNA_transf PF02534.14 EDN07529.1 - 0.024 13.4 0.0 0.043 12.6 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer DDE_1 PF03184.19 EDN07531.1 - 5.2e-49 166.3 0.1 6e-33 114.0 0.0 3.5 2 1 1 3 3 3 3 DDE superfamily endonuclease DDE_3 PF13358.6 EDN07531.1 - 1.2e-06 28.3 0.4 0.00096 18.9 0.0 4.2 4 0 0 4 4 4 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07531.1 - 2e-06 27.7 0.0 0.01 15.9 0.0 2.5 2 0 0 2 2 2 2 Tc5 transposase DNA-binding domain LINES_C PF14695.6 EDN07531.1 - 0.012 15.0 0.0 5.6 6.5 0.0 3.5 3 0 0 3 3 3 0 Lines C-terminus Phenol_hyd_sub PF06099.11 EDN07531.1 - 0.05 13.6 0.1 9.7 6.3 0.0 2.4 2 0 0 2 2 2 0 Phenol hydroxylase subunit DUF3656 PF12392.8 EDN07531.1 - 0.13 12.9 0.0 34 5.1 0.0 3.0 3 0 0 3 3 3 0 Collagenase DUF4658 PF15555.6 EDN07532.1 - 0.077 13.1 0.0 0.09 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) OrsD PF12013.8 EDN07534.1 - 5.2e-37 126.8 5.5 5.2e-37 126.8 5.5 2.5 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DEAD PF00270.29 EDN07534.1 - 2.1e-13 50.4 0.0 5.8e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN07534.1 - 2.4e-07 30.9 0.0 2.2e-06 27.8 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-H2C2_5 PF13909.6 EDN07534.1 - 0.26 11.1 3.5 1 9.2 1.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF4658 PF15555.6 EDN07534.1 - 0.41 10.8 1.9 6.8 6.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) DUF913 PF06025.12 EDN07534.1 - 4.1 6.3 8.2 0.67 8.9 1.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 EDN07534.1 - 8.8 4.3 12.1 17 3.4 12.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi C2 PF00168.30 EDN07535.1 - 2.1e-12 47.2 0.0 4e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.25 EDN07536.1 - 1.8e-61 207.8 0.0 2.5e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07536.1 - 6.7e-33 114.1 0.0 9.9e-33 113.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN07536.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like IGR PF09597.10 EDN07537.1 - 4.1e-24 84.4 0.5 7.6e-24 83.6 0.5 1.5 1 0 0 1 1 1 1 IGR protein motif p450 PF00067.22 EDN07538.1 - 1.9e-67 228.0 0.0 2.4e-67 227.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 K-box PF01486.17 EDN07538.1 - 0.023 14.8 0.1 0.054 13.7 0.1 1.5 1 0 0 1 1 1 0 K-box region Pkinase PF00069.25 EDN07539.1 - 1.6e-67 227.6 0.0 2.2e-67 227.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07539.1 - 2.7e-28 98.9 0.0 4e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EDN07539.1 - 3.5e-17 62.5 0.2 7.6e-17 61.4 0.2 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EDN07539.1 - 2.1e-06 28.0 0.0 4.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 EDN07539.1 - 2.2e-05 23.4 0.0 3.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDN07539.1 - 7.5e-05 22.2 0.5 0.0023 17.3 0.1 2.8 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDN07539.1 - 0.0065 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN07539.1 - 0.026 14.4 0.1 0.27 11.1 0.1 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EDN07539.1 - 0.11 11.4 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF2961 PF11175.8 EDN07539.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2961) PI3_PI4_kinase PF00454.27 EDN07540.1 - 2.3e-36 125.9 0.0 7.7e-34 117.6 0.0 2.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDN07540.1 - 7.5e-25 87.4 0.2 2e-24 86.0 0.2 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EDN07540.1 - 0.13 11.5 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) YTH PF04146.15 EDN07542.1 - 6.5e-39 133.5 0.0 6.9e-36 123.7 0.0 2.4 1 1 1 2 2 2 2 YT521-B-like domain RRM_1 PF00076.22 EDN07542.1 - 6.9e-06 25.8 0.0 1.2e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN07542.1 - 0.08 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif ArfGap PF01412.18 EDN07544.1 - 1.5e-32 112.1 0.0 1.5e-32 112.1 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EDN07544.1 - 3.2e-21 76.1 15.6 6.6e-21 75.1 15.6 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EDN07544.1 - 2.2e-12 47.4 0.2 2.2e-12 47.4 0.2 2.1 2 0 0 2 2 2 1 PH domain EMP24_GP25L PF01105.24 EDN07544.1 - 0.1 12.5 1.4 0.45 10.4 1.2 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF3435 PF11917.8 EDN07546.1 - 1.2e-154 515.2 0.0 1.6e-154 514.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) HTH_38 PF13936.6 EDN07546.1 - 0.087 12.6 0.9 0.23 11.2 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain zf-C2H2_3rep PF18868.1 EDN07546.1 - 0.25 12.0 1.8 0.5 11.0 1.8 1.5 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EDN07546.1 - 0.33 11.9 6.8 3.6 8.7 0.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_2 PF07727.14 EDN07547.1 - 1.3e-58 198.6 0.0 2.1e-58 197.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN07547.1 - 1.4e-11 44.6 0.0 9e-11 42.0 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN07547.1 - 1.5e-07 31.2 0.0 3.4e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN07547.1 - 0.00014 21.5 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN07547.1 - 0.00017 21.2 0.0 0.00046 19.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) rve_3 PF13683.6 EDN07547.1 - 0.047 13.5 0.0 0.14 11.9 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain CALM_bind PF16025.5 EDN07547.1 - 0.057 13.9 0.4 0.16 12.4 0.4 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding DUF3322 PF11795.8 EDN07549.1 - 0.049 13.7 0.0 0.059 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Pectate_lyase_3 PF12708.7 EDN07550.1 - 1.6e-63 214.5 7.1 2.6e-57 194.1 0.5 2.9 3 0 0 3 3 3 2 Pectate lyase superfamily protein Peptidase_S8 PF00082.22 EDN07550.1 - 3.1e-08 33.3 0.0 6.6e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Subtilase family HALZ PF02183.18 EDN07551.1 - 1.6e-05 25.0 0.6 3e-05 24.1 0.6 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper ZapB PF06005.12 EDN07551.1 - 0.021 15.2 0.4 0.041 14.3 0.4 1.5 1 0 0 1 1 1 0 Cell division protein ZapB ATG16 PF08614.11 EDN07551.1 - 0.026 14.7 1.2 0.085 13.1 1.2 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TSC22 PF01166.18 EDN07551.1 - 0.058 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF4618 PF15397.6 EDN07551.1 - 0.079 12.4 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) bZIP_1 PF00170.21 EDN07551.1 - 6.1 7.0 6.8 0.27 11.3 0.8 1.8 2 0 0 2 2 2 0 bZIP transcription factor Myb_DNA-binding PF00249.31 EDN07552.1 - 9.5e-12 44.9 1.4 1.7e-11 44.1 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN07552.1 - 2.2e-06 27.8 0.3 4.3e-06 26.9 0.1 1.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain BCS1_N PF08740.11 EDN07553.1 - 1.9e-34 119.3 0.0 3.1e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN07553.1 - 1.7e-19 70.5 0.0 5.9e-19 68.8 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN07553.1 - 1e-05 26.0 0.1 2.4e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain PPV_E1_C PF00519.17 EDN07553.1 - 0.056 12.3 0.0 0.092 11.6 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_24 PF13479.6 EDN07553.1 - 0.061 13.0 0.0 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN07553.1 - 0.071 13.1 0.0 0.18 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDN07553.1 - 0.078 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDN07553.1 - 0.086 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 KaiC RuvB_N PF05496.12 EDN07553.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN07553.1 - 0.15 12.6 0.0 2.2 8.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain Bac_export_2 PF01312.19 EDN07553.1 - 0.2 10.8 0.2 0.3 10.2 0.2 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family RVT_1 PF00078.27 EDN07556.1 - 2.6e-40 138.3 0.0 3.9e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN07556.1 - 2.1e-13 50.1 0.0 6e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN07556.1 - 0.00025 20.6 0.1 0.00049 19.7 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 EDN07557.1 - 3.6e-07 29.8 0.0 0.0026 17.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07557.1 - 0.039 13.2 0.1 1.9 7.7 0.0 2.0 1 1 1 2 2 2 0 Protein tyrosine kinase Tcell_CD4_C PF12104.8 EDN07557.1 - 0.79 9.7 1.8 1.7 8.6 0.5 1.9 2 0 0 2 2 2 0 T cell CD4 receptor C terminal region Rad60-SLD PF11976.8 EDN07560.1 - 1.3e-23 82.5 0.0 7.2e-21 73.8 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EDN07560.1 - 0.0004 20.1 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin family CENP-B_dimeris PF09026.10 EDN07560.1 - 0.024 15.0 10.0 0.024 15.0 10.0 4.3 4 0 0 4 4 4 0 Centromere protein B dimerisation domain LSM PF01423.22 EDN07561.1 - 2.7e-20 71.8 0.0 3.1e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDN07561.1 - 0.0016 18.5 0.0 0.002 18.3 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EDN07561.1 - 0.039 14.1 0.0 0.043 13.9 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain Hfq PF17209.3 EDN07561.1 - 0.075 12.7 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Hfq protein IF-2B PF01008.17 EDN07562.1 - 1.3e-70 237.8 0.2 1.5e-70 237.6 0.2 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family RAMP4 PF06624.12 EDN07563.1 - 3.4e-22 78.3 0.1 4.3e-22 77.9 0.1 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Adaptin_N PF01602.20 EDN07564.1 - 7.2e-54 183.2 0.0 1.4e-53 182.3 0.0 1.5 1 1 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.22 EDN07564.1 - 9.9e-05 22.3 0.5 1.1 9.6 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EDN07564.1 - 0.00047 20.2 0.1 0.037 14.1 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN07564.1 - 0.27 11.7 7.6 0.36 11.3 0.0 3.6 4 0 0 4 4 4 0 HEAT repeats TPR_14 PF13428.6 EDN07565.1 - 5.6e-09 36.1 3.0 0.076 13.9 0.0 4.5 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDN07565.1 - 6.6e-08 32.4 0.2 5.8e-05 23.2 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN07565.1 - 7.8e-08 32.7 2.6 0.00016 22.1 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDN07565.1 - 9.1e-06 25.3 3.7 1.3e-05 24.8 0.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07565.1 - 1.4e-05 24.9 0.2 0.0015 18.6 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDN07565.1 - 7.7e-05 22.5 3.1 0.0047 16.9 0.3 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDN07565.1 - 0.00067 19.8 0.8 0.0031 17.6 0.3 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDN07565.1 - 0.0013 18.4 0.7 0.48 10.2 0.0 4.0 4 0 0 4 4 4 1 TPR repeat TPR_7 PF13176.6 EDN07565.1 - 0.0078 16.2 2.0 1.7 8.8 0.1 3.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDN07565.1 - 0.02 15.5 1.2 20 6.1 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EDN07565.1 - 0.025 14.5 0.0 1.1 9.1 0.0 2.6 2 1 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal DUF4129 PF13559.6 EDN07565.1 - 0.083 13.2 0.0 20 5.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) MPDZ_u10 PF16667.5 EDN07565.1 - 0.12 13.3 0.4 0.43 11.5 0.4 1.9 1 0 0 1 1 1 0 Unstructured region 10 on multiple PDZ protein TPR_12 PF13424.6 EDN07565.1 - 0.15 12.4 2.2 1.8 8.9 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07565.1 - 0.15 12.7 4.9 1.1 9.9 0.0 3.6 3 2 1 4 4 3 0 Tetratricopeptide repeat Syja_N PF02383.18 EDN07567.1 - 3.5e-72 243.4 0.0 4.7e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDN07567.1 - 3.4e-10 39.8 0.1 5.9e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Rer1 PF03248.13 EDN07568.1 - 0.052 13.3 0.0 0.055 13.2 0.0 1.1 1 0 0 1 1 1 0 Rer1 family G-patch PF01585.23 EDN07569.1 - 3.3e-05 23.7 0.1 0.00028 20.7 0.1 2.4 1 1 0 1 1 1 1 G-patch domain DAGAT PF03982.13 EDN07571.1 - 3.4e-92 308.5 0.0 4.4e-92 308.1 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.13 EDN07571.1 - 0.03 14.1 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Rer1 family Kinesin PF00225.23 EDN07573.1 - 8.8e-97 324.0 0.3 2.3e-96 322.7 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDN07573.1 - 6.1e-23 81.4 0.0 1.8e-22 79.9 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding MPS2 PF17060.5 EDN07573.1 - 0.097 11.9 3.8 0.067 12.5 1.8 1.7 1 1 0 1 1 1 0 Monopolar spindle protein 2 DNA_ligase_OB PF03120.16 EDN07573.1 - 0.15 12.0 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent DNA ligase OB-fold domain Vfa1 PF08432.10 EDN07573.1 - 0.41 11.0 9.1 4.4 7.6 0.8 2.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 ExsD PF16806.5 EDN07573.1 - 5.1 6.9 6.8 2.1 8.2 3.2 1.9 2 0 0 2 2 2 0 Antiactivator protein ExsD N-SET PF11764.8 EDN07574.1 - 5.6e-61 205.6 0.8 5.6e-61 205.6 0.8 2.6 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EDN07574.1 - 1.2e-27 95.3 0.9 3.3e-27 93.9 0.9 1.8 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 EDN07574.1 - 6.4e-20 72.2 0.2 6.4e-20 72.2 0.2 3.7 4 0 0 4 4 4 1 SET domain RRM_1 PF00076.22 EDN07574.1 - 0.0003 20.6 0.0 0.00063 19.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HTH_21 PF13276.6 EDN07574.1 - 0.066 13.3 0.3 0.17 12.1 0.3 1.7 1 0 0 1 1 1 0 HTH-like domain AMP-binding PF00501.28 EDN07575.1 - 1.4e-124 415.9 0.0 3.2e-63 213.8 0.0 3.2 2 1 1 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EDN07575.1 - 6.6e-85 285.5 0.0 3.1e-36 125.0 0.0 3.9 4 0 0 4 4 4 3 Condensation domain PP-binding PF00550.25 EDN07575.1 - 1.8e-32 111.5 0.1 5.8e-11 42.6 0.0 3.9 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EDN07575.1 - 3.8e-05 24.6 0.0 0.45 11.5 0.0 3.3 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EDN07576.1 - 1.6e-57 195.0 0.0 2.4e-57 194.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EDN07576.1 - 1e-55 189.2 0.0 2.5e-35 122.1 0.0 3.5 3 1 1 4 4 4 3 Condensation domain PP-binding PF00550.25 EDN07576.1 - 1.3e-12 47.9 0.5 4.8e-12 46.0 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site MFS_1 PF07690.16 EDN07577.1 - 2.1e-20 72.9 28.3 2.1e-20 72.9 28.3 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN07577.1 - 1.1e-05 24.1 5.3 1.1e-05 24.1 5.3 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PBP1_TM PF14812.6 EDN07577.1 - 3.9 7.9 8.1 11 6.5 8.1 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.9 EDN07577.1 - 7.5 5.6 10.1 10 5.1 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SIS PF01380.22 EDN07578.1 - 9.7e-58 193.7 0.1 1.2e-31 109.3 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EDN07578.1 - 9.3e-17 61.5 0.0 1.7e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDN07578.1 - 2.2e-10 40.5 0.0 4.9e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EDN07578.1 - 0.0033 16.4 0.0 0.0052 15.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Holin_BhlA PF10960.8 EDN07578.1 - 0.13 12.2 0.0 0.41 10.6 0.0 1.9 1 0 0 1 1 1 0 BhlA holin family DMRL_synthase PF00885.19 EDN07579.1 - 6.8e-53 178.3 0.0 8.4e-53 178.0 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DUF3830 PF12903.7 EDN07579.1 - 0.039 13.6 0.0 0.1 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3830) Proteasome PF00227.26 EDN07580.1 - 6.5e-45 153.0 0.0 7.9e-32 110.3 0.0 2.3 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EDN07580.1 - 4.1e-12 45.5 0.0 8.9e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Zn-ribbon_8 PF09723.10 EDN07581.1 - 0.015 15.4 1.7 0.08 13.1 0.9 2.2 2 0 0 2 2 2 0 Zinc ribbon domain A2L_zn_ribbon PF08792.10 EDN07581.1 - 0.4 10.5 3.2 1.8 8.4 3.2 2.0 1 1 0 1 1 1 0 A2L zinc ribbon domain Iso_dh PF00180.20 EDN07583.1 - 8.9e-73 245.4 0.0 1e-72 245.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Copine PF07002.16 EDN07583.1 - 0.093 12.2 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Copine WBS_methylT PF12589.8 EDN07584.1 - 5.8e-15 55.8 1.2 9.8e-15 55.1 1.2 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 EDN07584.1 - 3.4e-10 40.5 0.0 6.6e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN07584.1 - 5.4e-10 39.8 0.0 8.7e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN07584.1 - 7e-05 23.5 0.0 0.00018 22.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDN07584.1 - 0.00019 21.3 0.0 0.00033 20.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EDN07584.1 - 0.00048 19.9 0.0 0.00082 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN07584.1 - 0.002 18.0 0.0 0.0028 17.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN07584.1 - 0.0038 16.6 0.0 0.012 15.0 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EDN07584.1 - 0.092 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_33 PF10017.9 EDN07584.1 - 0.098 11.8 0.0 0.19 10.9 0.0 1.4 1 1 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent PrmA PF06325.13 EDN07584.1 - 0.22 10.9 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Erv26 PF04148.13 EDN07585.1 - 4.4e-94 314.1 0.8 5.1e-94 313.9 0.8 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Ferric_reduct PF01794.19 EDN07585.1 - 0.00015 21.9 5.8 0.0039 17.3 2.5 2.2 2 0 0 2 2 2 2 Ferric reductase like transmembrane component RhoGAP PF00620.27 EDN07587.1 - 8.5e-40 136.0 0.0 2.1e-39 134.8 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EDN07587.1 - 4.7e-15 56.0 0.1 1.7e-14 54.2 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EDN07587.1 - 0.0089 16.3 0.0 0.039 14.2 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain MDM31_MDM32 PF08118.11 EDN07589.1 - 1.8e-247 822.2 0.0 2.2e-247 821.9 0.0 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins KH_8 PF17903.1 EDN07590.1 - 1.2e-06 28.5 0.0 2.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDN07590.1 - 0.05 13.4 0.7 0.11 12.3 0.7 1.6 1 0 0 1 1 1 0 KH domain Proteasome PF00227.26 EDN07591.1 - 1.1e-31 109.8 0.2 2.7e-31 108.6 0.1 1.6 2 0 0 2 2 2 1 Proteasome subunit RT_RNaseH PF17917.1 EDN07593.1 - 3.3e-05 24.1 0.2 4.6e-05 23.6 0.2 1.4 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Pih1_fungal_CS PF18482.1 EDN07593.1 - 0.053 14.1 0.1 0.094 13.3 0.1 1.5 1 1 1 2 2 2 0 Fungal Pih1 CS domain RT_RNaseH PF17917.1 EDN07595.1 - 8.1e-35 119.3 0.0 6.8e-34 116.3 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN07595.1 - 4.3e-31 108.1 0.0 7.5e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN07595.1 - 1.1e-23 83.1 0.3 1.8e-12 47.2 0.0 3.1 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN07595.1 - 3e-19 68.9 0.2 7.8e-19 67.5 0.2 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN07595.1 - 4.9e-15 55.8 0.0 1.8e-14 53.9 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN07595.1 - 6.9e-14 51.5 1.5 2e-13 50.0 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC PF00098.23 EDN07595.1 - 1e-05 25.3 0.5 2.1e-05 24.4 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 EDN07595.1 - 1.8e-05 24.9 0.1 3.9e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN07595.1 - 0.033 14.4 1.0 0.36 11.0 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 zf-CCHC_2 PF13696.6 EDN07595.1 - 0.046 13.6 0.2 0.11 12.3 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle PSII_Pbs27 PF13326.6 EDN07595.1 - 0.13 12.6 0.0 0.77 10.1 0.0 2.3 2 0 0 2 2 2 0 Photosystem II Pbs27 zf-CCHC_4 PF14392.6 EDN07595.1 - 0.18 11.6 1.1 0.41 10.4 1.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Retrotran_gag_2 PF14223.6 EDN07595.1 - 0.34 10.6 1.6 0.88 9.2 1.6 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type HCNGP PF07818.13 EDN07596.1 - 6.1e-32 110.1 0.2 1.1e-31 109.3 0.2 1.4 1 0 0 1 1 1 1 HCNGP-like protein Proteasome PF00227.26 EDN07597.1 - 8.9e-28 97.1 0.0 1.2e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit FAA_hydrolase PF01557.18 EDN07598.1 - 1.1e-65 221.3 0.0 1.5e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Complex1_LYR PF05347.15 EDN07599.1 - 1.6e-16 60.1 2.4 1.9e-16 59.8 2.4 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDN07599.1 - 1.4e-06 29.0 0.7 1.7e-06 28.7 0.7 1.1 1 0 0 1 1 1 1 Complex1_LYR-like RVT_2 PF07727.14 EDN07600.1 - 3e-15 56.5 0.0 4.2e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSP20 PF00011.21 EDN07601.1 - 2.7e-19 69.2 0.1 2.1e-12 47.1 0.0 2.3 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EDN07601.1 - 1e-06 28.2 0.0 0.0078 15.8 0.0 2.2 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Autophagy_act_C PF03987.15 EDN07603.1 - 2.6e-05 24.7 0.0 5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain DNA_pol_phi PF04931.13 EDN07603.1 - 0.0009 17.5 18.2 0.001 17.3 18.2 1.1 1 0 0 1 1 1 1 DNA polymerase phi Nop14 PF04147.12 EDN07603.1 - 0.013 13.8 13.1 0.013 13.7 13.1 1.0 1 0 0 1 1 1 0 Nop14-like family CNDH2_C PF16858.5 EDN07603.1 - 0.03 14.2 3.4 0.035 14.0 3.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Sigma70_ner PF04546.13 EDN07603.1 - 0.054 13.4 13.3 0.078 12.9 13.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region BUD22 PF09073.10 EDN07603.1 - 0.11 11.9 9.2 0.12 11.7 9.2 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EDN07603.1 - 0.26 10.7 14.5 0.3 10.5 14.5 1.1 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 EDN07603.1 - 0.62 9.2 30.7 0.81 8.8 30.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Vfa1 PF08432.10 EDN07603.1 - 0.81 10.0 4.5 1.1 9.6 4.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 EDN07603.1 - 2 6.6 15.4 2.4 6.4 15.4 1.1 1 0 0 1 1 1 0 CDC45-like protein UPF0560 PF10577.9 EDN07603.1 - 3.2 6.1 7.0 4.1 5.8 7.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SGT1 PF07093.11 EDN07603.1 - 3.2 6.1 12.2 3.9 5.8 12.2 1.1 1 0 0 1 1 1 0 SGT1 protein PPP4R2 PF09184.11 EDN07603.1 - 6.7 6.2 18.7 8.9 5.8 18.7 1.1 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 EDN07603.1 - 7.2 5.8 26.2 11 5.3 26.2 1.3 1 0 0 1 1 1 0 NOA36 protein RRN3 PF05327.11 EDN07603.1 - 7.5 5.0 21.3 9.4 4.6 21.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2722 PF10846.8 EDN07603.1 - 8.1 5.3 9.5 9.4 5.1 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RRM_1 PF00076.22 EDN07604.1 - 6e-09 35.6 0.0 1.3e-08 34.6 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN07604.1 - 5.4e-05 22.8 0.0 9e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 EDN07604.1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Calcipressin RRM_occluded PF16842.5 EDN07604.1 - 0.091 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif WD40 PF00400.32 EDN07605.1 - 7.2e-13 48.8 14.9 0.0033 18.2 0.4 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07605.1 - 8.2e-07 29.2 0.0 0.012 15.9 0.0 4.5 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3642 PF12182.8 EDN07605.1 - 0.11 12.8 0.0 4.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Bacterial lipoprotein DDE_1 PF03184.19 EDN07606.1 - 9.8e-23 80.7 0.0 2e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN07606.1 - 4.4e-05 23.3 0.1 0.00064 19.5 0.0 2.6 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07606.1 - 0.0018 18.3 0.0 0.0073 16.3 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN07606.1 - 0.026 14.3 0.5 0.026 14.3 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN07606.1 - 0.044 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) zf-C2H2 PF00096.26 EDN07608.1 - 0.00063 20.1 0.3 0.00063 20.1 0.3 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EDN07608.1 - 0.00067 19.6 0.2 0.00067 19.6 0.2 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDN07608.1 - 0.038 14.8 0.2 0.038 14.8 0.2 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Glyco_tranf_2_3 PF13641.6 EDN07609.1 - 7.6e-33 114.3 0.0 1.9e-32 113.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDN07609.1 - 2.6e-10 40.1 0.0 5.7e-10 38.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDN07609.1 - 1.7e-07 31.2 0.0 3.3e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ank_4 PF13637.6 EDN07610.1 - 1.1e-18 67.4 0.1 1.5e-07 31.8 0.0 4.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDN07610.1 - 6.8e-12 45.8 0.0 9.3e-05 22.9 0.0 3.6 2 2 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EDN07610.1 - 7.7e-10 38.8 1.3 0.19 12.2 0.0 5.7 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EDN07610.1 - 4.1e-09 36.5 3.4 0.00017 21.8 0.0 5.1 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN07610.1 - 5.6e-09 35.5 0.6 0.21 12.2 0.0 5.7 6 1 0 6 6 6 2 Ankyrin repeat Rnf-Nqr PF02508.14 EDN07611.1 - 0.02 14.9 0.6 0.02 14.9 0.6 2.2 1 1 1 2 2 2 0 Rnf-Nqr subunit, membrane protein 7TMR-DISM_7TM PF07695.11 EDN07611.1 - 0.26 11.2 11.1 0.047 13.6 2.6 2.2 1 1 0 2 2 2 0 7TM diverse intracellular signalling RRF_GI PF12614.8 EDN07612.1 - 0.087 13.0 0.3 0.15 12.2 0.3 1.3 1 0 0 1 1 1 0 Ribosome recycling factor Pkinase PF00069.25 EDN07614.1 - 1.1e-05 24.9 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN07614.1 - 2.3e-05 23.8 0.0 5.1e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN07614.1 - 0.00012 21.0 0.3 0.00058 18.7 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase HSDR_N_2 PF13588.6 EDN07614.1 - 0.0043 17.0 0.0 0.93 9.5 0.0 2.5 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) APH PF01636.23 EDN07614.1 - 0.0053 16.7 1.2 0.015 15.2 0.1 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Chromo PF00385.24 EDN07615.1 - 0.00048 20.0 0.0 0.0027 17.6 0.0 2.0 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Glyco_hydro_43 PF04616.14 EDN07617.1 - 8.4e-27 94.2 0.4 1.1e-26 93.9 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Lipase_3 PF01764.25 EDN07618.1 - 1.4e-30 106.0 0.0 2.2e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EDN07618.1 - 0.0058 17.2 0.5 0.014 16.1 0.4 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN07618.1 - 0.01 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN07618.1 - 0.011 15.0 0.1 0.025 13.9 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EDN07618.1 - 0.022 14.5 0.0 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Cutinase PF01083.22 EDN07618.1 - 0.034 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Cutinase PGAP1 PF07819.13 EDN07618.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein DUF2974 PF11187.8 EDN07618.1 - 0.17 11.4 0.0 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PBP1_TM PF14812.6 EDN07618.1 - 0.19 12.1 4.9 0.35 11.3 4.9 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PhoD PF09423.10 EDN07619.1 - 0.09 11.8 0.5 0.17 10.9 0.5 1.4 1 0 0 1 1 1 0 PhoD-like phosphatase WW PF00397.26 EDN07620.1 - 3.3e-11 43.1 0.4 7.6e-11 41.9 0.4 1.7 1 0 0 1 1 1 1 WW domain DUF4585 PF15232.6 EDN07620.1 - 0.011 15.7 0.0 0.011 15.7 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4585) Fungal_trans_2 PF11951.8 EDN07621.1 - 4.8e-19 68.4 4.1 7.2e-19 67.8 4.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN07621.1 - 0.00019 21.4 1.0 0.00039 20.5 1.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ecm29 PF13001.7 EDN07622.1 - 7.5e-166 552.7 0.1 9.8e-163 542.4 0.0 3.0 3 0 0 3 3 3 2 Proteasome stabiliser HEAT_EZ PF13513.6 EDN07622.1 - 0.00036 21.0 5.9 1.9 9.1 0.1 7.0 7 1 1 8 8 8 1 HEAT-like repeat IFRD PF05004.13 EDN07622.1 - 0.0048 16.0 1.3 0.16 11.1 0.3 3.3 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 EDN07622.1 - 0.012 16.0 0.7 4.4 7.8 0.1 5.2 4 0 0 4 4 4 0 HEAT repeats HEAT PF02985.22 EDN07622.1 - 0.12 12.7 13.9 0.82 10.1 0.0 8.5 10 0 0 10 10 10 0 HEAT repeat SNF2_N PF00176.23 EDN07623.1 - 4.1e-54 183.6 0.0 6.9e-54 182.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4 PF00097.25 EDN07623.1 - 1.7e-09 37.4 8.9 4.2e-09 36.1 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN07623.1 - 4.4e-09 36.0 9.5 1.4e-08 34.4 9.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN07623.1 - 1e-08 34.9 6.7 2.5e-08 33.6 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN07623.1 - 2.6e-07 30.9 11.2 6.3e-07 29.6 11.2 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EDN07623.1 - 6.6e-06 25.9 7.3 1.4e-05 24.9 7.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDN07623.1 - 3.7e-05 23.6 6.1 9.2e-05 22.4 6.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EDN07623.1 - 5.6e-05 23.4 7.7 0.00021 21.5 7.7 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 EDN07623.1 - 0.00019 21.8 0.0 0.0004 20.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TPR_2 PF07719.17 EDN07623.1 - 0.00046 20.1 0.3 0.0015 18.5 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat zf-RING_5 PF14634.6 EDN07623.1 - 0.0014 18.6 8.8 0.0031 17.4 8.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain TPR_14 PF13428.6 EDN07623.1 - 0.0054 17.5 0.3 0.027 15.3 0.3 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat zf-C3HC4_4 PF15227.6 EDN07623.1 - 0.0055 16.8 8.4 0.012 15.8 8.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 EDN07623.1 - 0.0063 16.5 0.2 0.013 15.5 0.2 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) TPR_1 PF00515.28 EDN07623.1 - 0.0074 16.1 0.1 0.021 14.6 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat Zn_ribbon_17 PF17120.5 EDN07623.1 - 0.088 12.4 6.9 0.2 11.3 6.9 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EDN07623.1 - 3.4 7.5 8.3 1.1 9.1 5.0 2.0 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain Pkinase PF00069.25 EDN07624.1 - 1.2e-15 57.6 0.0 3.9e-15 55.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07624.1 - 0.00057 19.3 0.0 0.0012 18.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN07624.1 - 0.065 12.0 0.2 0.37 9.5 0.0 1.9 1 1 0 2 2 2 0 Fungal protein kinase COesterase PF00135.28 EDN07625.1 - 1.4e-66 225.5 0.0 2.8e-66 224.4 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EDN07625.1 - 1.9e-09 37.7 0.2 4e-09 36.6 0.2 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDN07625.1 - 0.00073 19.1 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Pribosyltran PF00156.27 EDN07626.1 - 1.5e-16 60.3 0.0 2.2e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PMP22_Claudin PF00822.20 EDN07626.1 - 0.14 12.1 0.1 0.21 11.5 0.1 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family YhhN PF07947.14 EDN07627.1 - 0.039 13.6 0.2 0.34 10.5 0.2 2.3 3 0 0 3 3 3 0 YhhN family DUF4870 PF09685.10 EDN07627.1 - 0.065 13.4 2.0 0.093 12.8 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) Phage_holin_3_6 PF07332.11 EDN07627.1 - 0.07 13.2 0.8 0.78 9.8 0.1 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF983 PF06170.12 EDN07627.1 - 0.85 10.1 2.6 1.8 9.0 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Ank_2 PF12796.7 EDN07628.1 - 3.3e-19 69.2 8.3 8.4e-13 48.7 1.7 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN07628.1 - 7.1e-13 47.5 1.2 0.003 17.9 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EDN07628.1 - 9.5e-12 44.9 2.9 1.3e-05 25.3 0.5 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN07628.1 - 8.5e-10 39.0 0.4 0.0024 18.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN07628.1 - 6.4e-09 35.9 5.0 0.0084 16.5 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat PMM PF03332.13 EDN07629.1 - 9.5e-103 342.7 0.1 1.1e-102 342.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EDN07629.1 - 0.0027 17.5 0.0 0.0054 16.5 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.13 EDN07629.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1640 PF07798.11 EDN07630.1 - 1.1e-55 188.4 5.3 1.3e-55 188.2 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Trypsin_2 PF13365.6 EDN07631.1 - 8.8e-25 88.3 0.0 1.4e-24 87.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EDN07631.1 - 0.0078 16.0 0.1 0.18 11.6 0.0 2.4 1 1 0 2 2 2 1 Trypsin PNGaseA PF12222.8 EDN07632.1 - 1.3e-104 350.5 0.3 6.8e-95 318.5 0.0 2.2 1 1 1 2 2 2 2 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Fungal_trans PF04082.18 EDN07633.1 - 3.6e-18 65.5 0.8 6e-18 64.8 0.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN07633.1 - 1.2e-07 31.7 8.0 2.3e-07 30.8 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EDN07634.1 - 0.0006 18.9 41.3 0.003 16.5 38.2 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily DnaJ PF00226.31 EDN07636.1 - 4.3e-17 62.0 0.2 7.7e-17 61.2 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Bacteriocin_IIc PF10439.9 EDN07636.1 - 1.7 8.8 15.1 0.65 10.2 10.7 2.1 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide DnaJ PF00226.31 EDN07637.1 - 2.4e-08 34.0 0.0 1.6e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain PRA1 PF03208.19 EDN07638.1 - 1.6e-23 82.9 0.2 2.4e-23 82.4 0.2 1.2 1 0 0 1 1 1 1 PRA1 family protein Frag1 PF10277.9 EDN07640.1 - 2.5e-23 82.8 6.9 2.3e-15 56.7 0.1 2.0 1 1 1 2 2 2 2 Frag1/DRAM/Sfk1 family ABC2_membrane_2 PF12679.7 EDN07640.1 - 0.0028 17.0 0.2 0.0028 17.0 0.2 1.5 2 0 0 2 2 2 1 ABC-2 family transporter protein SUR7 PF06687.12 EDN07640.1 - 0.012 15.2 3.6 0.02 14.5 3.6 1.3 1 0 0 1 1 1 0 SUR7/PalI family CitMHS PF03600.16 EDN07640.1 - 0.022 13.9 0.3 0.04 13.1 0.2 1.6 1 1 0 1 1 1 0 Citrate transporter DUF998 PF06197.13 EDN07640.1 - 0.055 13.1 5.9 0.4 10.2 5.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF998) Y_phosphatase3 PF13350.6 EDN07641.1 - 1.6e-25 90.4 0.0 1.4e-18 67.7 0.0 2.4 3 0 0 3 3 3 2 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EDN07641.1 - 6.5e-06 25.8 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDN07641.1 - 0.027 14.0 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FTA2 PF13095.6 EDN07642.1 - 0.027 14.1 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 SpoIISB_antitox PF14185.6 EDN07642.1 - 0.071 13.0 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Antitoxin SpoIISB, type II toxin-antitoxin system Eisosome1 PF12757.7 EDN07644.1 - 2.2e-17 63.5 11.0 2.2e-17 63.5 11.0 3.8 4 2 0 4 4 4 1 Eisosome protein 1 Acetyltransf_3 PF13302.7 EDN07645.1 - 5.8e-12 46.5 0.0 8.1e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN07645.1 - 4e-05 23.8 0.0 6.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EDN07645.1 - 9.7e-05 22.6 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_16 PF13191.6 EDN07646.1 - 0.0023 18.3 0.0 0.033 14.6 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EDN07646.1 - 0.02 15.4 0.0 0.12 12.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EDN07646.1 - 0.079 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 EDN07647.1 - 5.7e-29 101.2 52.5 2.3e-21 76.1 27.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Yae1_N PF09811.9 EDN07648.1 - 0.0001 21.9 15.5 3.5 7.4 15.5 2.9 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Romo1 PF10247.9 EDN07648.1 - 0.018 15.4 25.1 1.8e+04 -3.9 25.1 3.1 1 1 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Keratin_2_head PF16208.5 EDN07648.1 - 0.019 15.1 8.2 0.028 14.6 8.2 1.2 1 0 0 1 1 1 0 Keratin type II head Gly-zipper_Omp PF13488.6 EDN07648.1 - 0.89 9.6 26.7 87 3.2 26.7 2.2 1 1 0 1 1 1 0 Glycine zipper Abhydrolase_9_N PF15420.6 EDN07648.1 - 1.6 8.7 8.2 96 2.9 8.2 2.3 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus B277 PF17623.2 EDN07648.1 - 2.7 7.0 9.9 4e+02 -0.1 9.9 2.3 1 1 0 1 1 1 0 Domain of unknown function DUF2798 PF11391.8 EDN07648.1 - 4.2 7.5 15.3 1e+03 -0.2 15.3 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2798) Pkinase PF00069.25 EDN07650.1 - 5.1e-58 196.5 0.1 5.1e-54 183.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07650.1 - 3.7e-37 128.0 0.0 2.5e-36 125.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN07650.1 - 3.8e-08 33.0 0.0 1.6e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDN07650.1 - 7e-07 28.5 0.1 8.7e-07 28.2 0.1 1.2 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDN07650.1 - 0.0028 17.6 0.8 0.2 11.5 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDN07650.1 - 0.064 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Prenyltrans PF00432.21 EDN07651.1 - 7e-30 102.5 11.0 2.6e-06 27.1 0.1 6.5 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EDN07651.1 - 0.0062 15.7 0.0 0.034 13.2 0.0 2.2 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain DDE_1 PF03184.19 EDN07652.1 - 1.6e-19 70.2 0.4 5.5e-19 68.5 0.0 2.1 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07652.1 - 8.6e-11 41.7 0.2 2.3e-09 37.2 0.0 2.9 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain PFL-like PF02901.15 EDN07652.1 - 0.0073 15.0 0.6 0.013 14.2 0.6 1.3 1 0 0 1 1 1 1 Pyruvate formate lyase-like DDE_3 PF13358.6 EDN07652.1 - 0.081 12.7 0.1 0.38 10.5 0.1 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease P3A PF08727.11 EDN07652.1 - 0.18 11.2 0.0 14 5.2 0.0 2.5 2 0 0 2 2 2 0 Poliovirus 3A protein like DDE_Tnp_1_7 PF13843.6 EDN07653.1 - 1.2e-23 84.0 0.4 7.4e-12 45.2 0.0 3.1 2 1 1 3 3 3 3 Transposase IS4 MFS_1 PF07690.16 EDN07655.1 - 8.2e-31 107.2 12.7 8.2e-31 107.2 12.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN07655.1 - 2e-05 23.6 11.8 2e-05 23.6 11.8 3.3 2 1 1 3 3 3 1 Sugar (and other) transporter Sec62 PF03839.16 EDN07655.1 - 0.21 11.1 0.3 0.48 9.9 0.3 1.6 1 1 0 1 1 1 0 Translocation protein Sec62 Phage_holin_3_1 PF05106.12 EDN07655.1 - 0.31 11.5 2.0 5.5 7.5 0.1 2.4 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) DUF2207 PF09972.9 EDN07655.1 - 1.2 7.8 0.0 1.2 7.8 0.0 3.0 1 1 2 3 3 3 0 Predicted membrane protein (DUF2207) MFS_1 PF07690.16 EDN07657.1 - 9.2e-09 34.7 31.9 1.5e-08 34.0 31.9 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDN07657.1 - 3.1e-06 27.0 11.6 3.7e-06 26.7 5.7 3.0 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF3566 PF12089.8 EDN07657.1 - 0.061 13.7 0.2 0.061 13.7 0.2 2.8 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) CagY_I PF14585.6 EDN07659.1 - 0.071 13.2 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 CagY type 1 repeat PT-TG PF14449.6 EDN07660.1 - 3.9e-06 26.7 0.1 1e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 Pre-toxin TG Ribosomal_L7Ae PF01248.26 EDN07661.1 - 7.5e-26 89.7 0.0 9.5e-26 89.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDN07661.1 - 0.00011 22.3 0.1 0.00013 22.1 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 EDN07661.1 - 0.00032 20.5 0.0 0.00046 20.0 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain E1-E2_ATPase PF00122.20 EDN07662.1 - 6.5e-51 172.4 9.1 1.8e-50 171.0 2.8 2.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDN07662.1 - 6.1e-47 159.7 5.3 6.1e-47 159.7 5.3 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDN07662.1 - 3.4e-25 89.6 0.2 2.2e-24 86.9 0.2 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDN07662.1 - 3e-18 65.7 0.0 6.2e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EDN07662.1 - 1.5e-15 56.6 0.0 5.8e-15 54.7 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDN07662.1 - 6.1e-09 36.0 1.2 1.2e-06 28.5 1.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDN07662.1 - 1.2e-06 29.1 0.2 5.6e-06 26.9 0.0 2.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase 14-3-3 PF00244.20 EDN07663.1 - 6.5e-97 323.4 0.6 8.4e-97 323.0 0.6 1.1 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 EDN07663.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Flagellar protein FlaF Peptidase_S32 PF05579.13 EDN07664.1 - 0.00077 18.7 0.0 0.00085 18.6 0.0 1.1 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 Peptidase_S46 PF10459.9 EDN07664.1 - 0.098 11.3 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 eIF3_subunit PF08597.10 EDN07665.1 - 5.5e-70 236.0 26.9 6.2e-70 235.9 26.9 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Nucleo_P87 PF07267.11 EDN07665.1 - 0.28 10.0 16.1 0.44 9.3 16.1 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF3246 PF11596.8 EDN07665.1 - 1.2 8.5 6.1 2.5 7.5 6.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) CPSF100_C PF13299.6 EDN07665.1 - 1.8 8.7 14.3 0.41 10.8 9.4 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PRCC PF10253.9 EDN07665.1 - 3.5 8.4 15.7 0.58 10.9 11.2 1.8 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting TFIIF_alpha PF05793.12 EDN07665.1 - 4.5 5.7 27.3 0.099 11.2 18.1 2.0 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DDE_1 PF03184.19 EDN07669.1 - 2.5e-20 72.9 0.1 2.1e-19 69.9 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease HNH_2 PF13391.6 EDN07669.1 - 4.4e-09 36.3 0.0 9.4e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07669.1 - 0.0043 17.0 0.0 0.015 15.3 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Enolase_N PF03952.16 EDN07670.1 - 1.1e-14 54.7 0.2 1.9e-14 54.0 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain AAA PF00004.29 EDN07671.1 - 7.1e-43 146.2 0.0 1.2e-42 145.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDN07671.1 - 1.4e-11 44.1 0.0 9.5e-11 41.5 0.0 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDN07671.1 - 1e-10 41.3 0.0 1.8e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDN07671.1 - 1.4e-07 32.0 0.0 6.7e-05 23.3 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EDN07671.1 - 1.6e-06 28.1 0.1 3.8e-05 23.7 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDN07671.1 - 3.1e-06 27.4 0.0 9.3e-06 25.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDN07671.1 - 7e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDN07671.1 - 0.00021 21.6 0.1 0.0061 16.8 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EDN07671.1 - 0.00032 19.9 0.0 0.00076 18.7 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EDN07671.1 - 0.00079 20.0 0.0 0.0026 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDN07671.1 - 0.0012 18.4 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EDN07671.1 - 0.0024 17.2 0.0 0.0043 16.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EDN07671.1 - 0.0037 16.7 0.0 0.0075 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EDN07671.1 - 0.004 17.2 0.0 0.0097 15.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EDN07671.1 - 0.0041 17.3 0.0 0.01 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EDN07671.1 - 0.0044 16.6 0.0 0.012 15.3 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain RNA_helicase PF00910.22 EDN07671.1 - 0.006 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 EDN07671.1 - 0.0062 16.3 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EDN07671.1 - 0.0069 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EDN07671.1 - 0.0084 15.8 0.0 0.027 14.2 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EDN07671.1 - 0.013 15.4 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EDN07671.1 - 0.019 14.7 0.5 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN07671.1 - 0.02 14.6 0.0 0.057 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDN07671.1 - 0.035 13.4 0.3 0.14 11.5 0.0 2.1 3 0 0 3 3 3 0 KaiC AAA_30 PF13604.6 EDN07671.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDN07671.1 - 0.057 13.3 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 EDN07671.1 - 0.059 13.3 0.2 0.37 10.7 0.0 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea PhoH PF02562.16 EDN07671.1 - 0.065 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_23 PF13476.6 EDN07671.1 - 0.076 13.5 1.9 11 6.5 1.7 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDN07671.1 - 0.086 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDN07671.1 - 0.092 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDN07671.1 - 0.12 11.6 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 EDN07671.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF4482 PF14818.6 EDN07671.1 - 0.45 11.4 3.0 0.22 12.4 0.4 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4482) Glyco_hydro_47 PF01532.20 EDN07672.1 - 2.5e-166 554.1 0.0 2.9e-166 553.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4038 PF13204.6 EDN07672.1 - 0.0098 15.6 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) M20_dimer PF07687.14 EDN07673.1 - 7.8e-18 64.4 0.0 1.6e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EDN07673.1 - 8.1e-16 58.3 0.1 5.6e-15 55.6 0.1 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EDN07673.1 - 0.0028 17.4 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 EDN07673.1 - 0.071 12.1 0.0 1.1 8.2 0.0 2.1 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase HATPase_c PF02518.26 EDN07674.1 - 1.2e-19 70.9 0.0 2.4e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDN07674.1 - 6.2e-17 61.8 0.7 1.8e-09 37.7 0.1 3.3 2 1 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 EDN07674.1 - 4.6e-06 26.6 0.0 1.8e-05 24.7 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EDN07674.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.6 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4795 PF16043.5 EDN07674.1 - 0.19 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Ribosomal_L36e PF01158.18 EDN07675.1 - 3e-41 139.6 6.9 3.4e-41 139.4 6.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.9 EDN07675.1 - 0.0071 16.5 1.3 0.0083 16.3 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 LemA PF04011.12 EDN07675.1 - 0.038 13.8 0.3 0.045 13.6 0.3 1.2 1 0 0 1 1 1 0 LemA family PBS_linker_poly PF00427.21 EDN07675.1 - 0.093 12.8 0.2 0.11 12.6 0.2 1.1 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide DUF2207 PF09972.9 EDN07675.1 - 0.13 11.0 0.1 0.14 10.9 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TUG-UBL1 PF11470.8 EDN07676.1 - 1.8e-24 85.8 0.3 4.8e-24 84.3 0.1 1.9 2 0 0 2 2 2 1 TUG ubiquitin-like domain RBD PF02196.15 EDN07676.1 - 0.02 15.0 0.1 0.051 13.6 0.1 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain Cobl PF09469.10 EDN07676.1 - 0.11 12.8 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Cordon-bleu ubiquitin-like domain FERM_N PF09379.10 EDN07676.1 - 0.12 12.3 0.0 4 7.5 0.0 2.5 2 0 0 2 2 2 0 FERM N-terminal domain Rad60-SLD PF11976.8 EDN07676.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PRCC PF10253.9 EDN07676.1 - 0.69 10.7 12.0 1.1 10.0 12.0 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Hemerythrin PF01814.23 EDN07677.1 - 6.1e-10 39.8 0.4 9.1e-10 39.3 0.4 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DEC-1_C PF04626.13 EDN07678.1 - 0.24 11.8 0.0 0.32 11.4 0.0 1.2 1 0 0 1 1 1 0 Dec-1 protein, C terminal region Pkinase PF00069.25 EDN07679.1 - 3.9e-09 36.3 0.0 4.7e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07679.1 - 2.4e-05 23.8 0.0 3e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Proteasome PF00227.26 EDN07680.1 - 1.7e-36 125.5 0.0 1.9e-36 125.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit NatB_MDM20 PF09797.9 EDN07681.1 - 7.5e-107 357.6 0.7 1.4e-106 356.7 0.7 1.4 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 EDN07681.1 - 1.1e-05 25.8 4.0 0.016 15.7 0.3 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat eIF3_subunit PF08597.10 EDN07682.1 - 5.4 6.8 16.0 11 5.9 16.0 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit AAA PF00004.29 EDN07684.1 - 7.9e-18 65.2 0.0 1.7e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN07684.1 - 2.8e-05 24.5 1.0 0.00012 22.5 0.2 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDN07684.1 - 0.00075 19.8 0.3 0.0049 17.2 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDN07684.1 - 0.013 15.5 0.0 0.041 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CPT PF07931.12 EDN07684.1 - 0.04 13.8 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein RuvB_N PF05496.12 EDN07684.1 - 0.046 13.5 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EDN07684.1 - 0.058 13.4 0.0 13 5.8 0.0 2.5 1 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDN07684.1 - 0.094 13.3 0.2 1.1 9.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF2718 PF10918.8 EDN07684.1 - 0.7 10.4 4.9 4 7.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) CHCH PF06747.13 EDN07685.1 - 0.00024 21.2 5.6 0.00047 20.2 5.6 1.5 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 EDN07685.1 - 0.024 14.8 2.0 0.037 14.3 2.0 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 EDN07685.1 - 0.2 12.0 4.4 0.4 11.0 4.4 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 WD40 PF00400.32 EDN07687.1 - 7.6e-18 64.6 13.1 3.5e-06 27.6 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat Proteasome PF00227.26 EDN07688.1 - 1.1e-37 129.4 0.0 1.2e-37 129.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit UCH PF00443.29 EDN07689.1 - 5.6e-22 78.5 0.0 1.5e-21 77.0 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDN07689.1 - 1e-11 45.0 0.2 2.4e-11 43.8 0.2 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EDN07689.1 - 0.0057 16.3 0.0 0.012 15.3 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SPOUT_MTase PF02590.17 EDN07691.1 - 0.047 13.7 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase WD40 PF00400.32 EDN07692.1 - 2.5e-51 170.5 27.0 6.8e-06 26.7 0.8 13.9 13 2 0 13 13 13 10 WD domain, G-beta repeat Utp13 PF08625.11 EDN07692.1 - 3.6e-49 166.3 0.2 5.7e-49 165.7 0.2 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EDN07692.1 - 1.2e-12 47.9 0.6 0.49 10.7 0.0 7.4 6 2 2 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN07692.1 - 1.5e-05 23.9 4.8 1.3 7.5 0.1 5.3 4 2 2 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDN07692.1 - 5.9e-05 22.2 0.2 0.07 12.1 0.0 3.9 5 1 0 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EDN07692.1 - 0.087 11.5 3.8 15 4.2 0.0 4.1 4 1 1 5 5 5 0 Nup133 N terminal like G-patch_2 PF12656.7 EDN07693.1 - 2.3e-24 85.3 0.2 7.8e-24 83.5 0.2 2.0 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 EDN07693.1 - 0.075 12.9 0.3 0.075 12.9 0.3 2.0 2 0 0 2 2 2 0 G-patch domain HNF-1_N PF04814.13 EDN07693.1 - 0.73 10.4 3.7 1.6 9.3 3.7 1.5 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus HSA PF07529.13 EDN07694.1 - 6.7e-14 52.0 0.1 6.7e-14 52.0 0.1 4.4 4 0 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.6 EDN07694.1 - 2.2e-13 50.2 0.4 8.1e-13 48.4 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN07694.1 - 0.0041 17.3 0.3 0.011 15.9 0.3 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SUIM_assoc PF16619.5 EDN07694.1 - 0.0059 16.6 0.0 0.0059 16.6 0.0 7.5 5 2 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 EDN07695.1 - 5.9e-09 36.4 0.0 0.23 12.4 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2_C PF09173.11 EDN07696.1 - 1.5e-34 118.1 0.3 3.2e-34 117.0 0.3 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EDN07696.1 - 5e-23 81.6 1.3 3e-22 79.1 1.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDN07696.1 - 1.4e-11 44.6 0.2 3.4e-11 43.4 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDN07696.1 - 0.0047 17.0 0.0 0.0092 16.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDN07696.1 - 0.0065 16.4 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EDN07696.1 - 0.1 12.7 0.0 0.3 11.1 0.0 1.9 1 0 0 1 1 1 0 Dynamin family RNA_polI_A14 PF08203.11 EDN07699.1 - 0.03 15.1 0.3 0.096 13.4 0.0 2.0 3 0 0 3 3 3 0 Yeast RNA polymerase I subunit RPA14 Peptidase_M48_N PF16491.5 EDN07700.1 - 2.7e-65 219.7 10.0 2.7e-65 219.7 10.0 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EDN07700.1 - 7.2e-47 159.7 0.0 2.2e-46 158.1 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_M56 PF05569.11 EDN07700.1 - 0.011 14.9 0.1 0.037 13.2 0.0 1.9 2 0 0 2 2 2 0 BlaR1 peptidase M56 DUF4538 PF15061.6 EDN07700.1 - 0.083 12.6 3.6 0.048 13.4 1.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Peptidase_M16_C PF05193.21 EDN07701.1 - 2.4e-19 70.1 0.0 1.1e-17 64.7 0.0 3.2 4 0 0 4 4 4 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDN07701.1 - 1.4e-06 28.4 0.4 4.8e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 EDN07701.1 - 3.9 6.5 5.1 3.9 6.5 3.5 1.8 2 0 0 2 2 2 0 Peptidase M16C associated Zw10 PF06248.13 EDN07702.1 - 1.6e-07 30.3 0.1 0.011 14.4 0.7 2.4 1 1 1 2 2 2 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EDN07702.1 - 1.8e-05 24.6 1.0 3.7e-05 23.5 0.1 2.0 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal DUF2840 PF11000.8 EDN07702.1 - 0.07 12.9 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2840) Syntaxin-6_N PF09177.11 EDN07702.1 - 0.37 11.4 6.8 0.76 10.4 0.1 3.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Seryl_tRNA_N PF02403.22 EDN07702.1 - 0.46 10.7 4.1 2.3 8.5 1.8 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain OEP PF02321.18 EDN07702.1 - 0.67 9.7 4.6 1.4 8.7 4.6 1.4 1 0 0 1 1 1 0 Outer membrane efflux protein HIP1_clath_bdg PF16515.5 EDN07702.1 - 1.6 9.4 5.8 9.3 6.9 5.7 2.3 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NPV_P10 PF05531.12 EDN07702.1 - 1.9 9.0 5.5 24 5.5 0.1 4.1 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EDN07702.1 - 9.9 6.3 8.4 7.7 6.7 3.4 2.9 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family NLE PF08154.12 EDN07703.1 - 1.7e-18 66.9 0.1 3.6e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 EDN07703.1 - 3.9e-18 65.5 21.8 2.9e-08 34.2 0.4 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 EDN07703.1 - 0.00062 18.5 5.3 0.088 11.4 0.4 2.6 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Ribosomal_S13 PF00416.22 EDN07704.1 - 1.1e-12 48.5 0.8 1.6e-12 47.9 0.8 1.3 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Pro_isomerase PF00160.21 EDN07705.1 - 1.4e-49 168.4 0.5 1.7e-49 168.1 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD APH PF01636.23 EDN07706.1 - 1.8e-07 31.4 0.6 1.5e-06 28.3 0.5 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Scm3 PF10384.9 EDN07706.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Centromere protein Scm3 APH PF01636.23 EDN07707.1 - 1e-11 45.2 0.0 1.5e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fungal_trans_2 PF11951.8 EDN07709.1 - 0.005 15.7 0.3 0.017 14.0 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain NmrA PF05368.13 EDN07710.1 - 1.5e-17 63.9 0.0 2.5e-17 63.2 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN07710.1 - 8.5e-12 45.3 0.0 2.5e-11 43.8 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding CAP59_mtransfer PF11735.8 EDN07710.1 - 0.16 11.6 0.0 0.34 10.6 0.0 1.6 1 1 0 1 1 1 0 Cryptococcal mannosyltransferase 1 DEAD PF00270.29 EDN07711.1 - 7.5e-50 169.1 0.0 1.4e-49 168.2 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN07711.1 - 3.9e-31 107.7 0.0 9.7e-31 106.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07711.1 - 0.0036 17.3 0.0 0.0072 16.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EDN07711.1 - 0.054 12.3 0.0 0.91 8.2 0.0 2.1 1 1 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 INSIG PF07281.12 EDN07713.1 - 1.1e-61 208.2 1.1 1.3e-61 208.0 1.1 1.0 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) MutL PF13941.6 EDN07713.1 - 0.091 11.3 0.1 0.1 11.2 0.1 1.1 1 0 0 1 1 1 0 MutL protein AICARFT_IMPCHas PF01808.18 EDN07714.1 - 3.5e-88 295.9 0.0 5.4e-88 295.3 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EDN07714.1 - 2e-25 88.8 0.0 3.7e-25 87.9 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain Clathrin PF00637.20 EDN07715.1 - 7.4e-194 635.4 41.9 2.6e-34 118.2 1.1 7.3 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EDN07715.1 - 4.4e-26 90.6 0.5 2e-25 88.5 0.0 2.5 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 EDN07715.1 - 7e-11 41.9 0.6 0.45 10.9 0.0 6.2 6 0 0 6 6 6 3 Clathrin propeller repeat Clathrin-link PF09268.10 EDN07715.1 - 7.1e-09 34.9 0.0 1.6e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_7 PF13176.6 EDN07715.1 - 0.0028 17.6 1.8 78 3.7 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07715.1 - 0.0044 17.1 2.3 1.7 9.0 0.1 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat VapB_antitoxin PF09957.9 EDN07715.1 - 0.007 16.3 0.3 0.033 14.1 0.0 2.3 2 0 0 2 2 2 1 Bacterial antitoxin of type II TA system, VapB TPR_14 PF13428.6 EDN07715.1 - 0.0091 16.7 7.6 0.59 11.1 0.1 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 EDN07715.1 - 0.027 14.8 0.1 1.7 9.0 0.1 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Vps39_1 PF10366.9 EDN07715.1 - 0.047 14.0 6.2 5.2 7.4 0.0 5.4 4 1 1 5 5 5 0 Vacuolar sorting protein 39 domain 1 PPR PF01535.20 EDN07715.1 - 0.29 11.5 1.0 37 4.9 0.0 4.4 4 0 0 4 4 4 0 PPR repeat DIM1 PF02966.16 EDN07716.1 - 3.4e-67 224.3 0.2 4e-67 224.0 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EDN07716.1 - 0.0012 18.8 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDN07716.1 - 0.042 14.2 0.8 0.067 13.5 0.8 1.4 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 EDN07716.1 - 0.11 12.3 0.2 0.75 9.6 0.1 1.9 1 1 1 2 2 2 0 Thioredoxin CPSase_L_D2 PF02786.17 EDN07717.1 - 6.6e-80 267.6 0.1 1e-79 267.0 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EDN07717.1 - 1.7e-70 236.8 0.0 3e-70 236.0 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EDN07717.1 - 8.9e-39 132.4 0.0 1.7e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDN07717.1 - 1.5e-29 102.2 0.0 3.4e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EDN07717.1 - 1.2e-28 100.4 0.0 2e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 HMGL-like Dala_Dala_lig_C PF07478.13 EDN07717.1 - 3.9e-10 39.6 0.0 7.6e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDN07717.1 - 4.1e-08 33.0 0.0 7.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.22 EDN07717.1 - 7.2e-06 25.8 1.9 0.00056 19.7 0.1 3.1 2 1 1 3 3 3 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 EDN07717.1 - 0.0001 22.4 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EDN07717.1 - 0.00049 19.7 0.1 0.0013 18.4 0.1 1.6 1 1 0 1 1 1 1 RimK-like ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EDN07717.1 - 0.0043 16.8 1.1 2.2 8.2 0.0 3.1 3 0 0 3 3 3 1 Biotin-lipoyl like ATP-grasp_4 PF13535.6 EDN07717.1 - 0.0066 16.1 0.1 0.056 13.0 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain HlyD_D23 PF16576.5 EDN07717.1 - 0.038 13.2 0.1 1.4 8.0 0.0 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GARS_A PF01071.19 EDN07717.1 - 0.057 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 EDN07717.1 - 0.11 11.7 0.0 0.28 10.4 0.0 1.6 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Beta-lactamase PF00144.24 EDN07718.1 - 1.4e-61 208.6 0.1 1.7e-61 208.3 0.1 1.0 1 0 0 1 1 1 1 Beta-lactamase Ribosomal_L5_C PF00673.21 EDN07721.1 - 1.2e-21 76.7 0.0 2.5e-21 75.6 0.0 1.6 1 1 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDN07721.1 - 4e-20 71.9 0.0 1.1e-19 70.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 LSM PF01423.22 EDN07722.1 - 5.2e-18 64.5 0.0 7.1e-18 64.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain MPC PF03650.13 EDN07723.1 - 2.5e-21 75.9 0.7 8.4e-17 61.3 0.1 2.1 1 1 1 2 2 2 2 Mitochondrial pyruvate carriers Cleaved_Adhesin PF07675.11 EDN07723.1 - 0.046 13.7 0.1 0.057 13.3 0.1 1.3 1 0 0 1 1 1 0 Cleaved Adhesin Domain Aa_trans PF01490.18 EDN07724.1 - 7.1e-60 202.8 22.2 4.6e-38 131.0 4.7 2.0 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EDN07724.1 - 0.075 12.1 11.5 0.13 11.3 11.5 1.3 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family AA_permease PF00324.21 EDN07725.1 - 5.8e-25 87.8 32.3 6.3e-17 61.3 24.3 2.2 1 1 1 2 2 2 2 Amino acid permease SLC12 PF03522.15 EDN07725.1 - 1.6e-12 47.2 0.0 1.4e-05 24.3 0.0 2.3 2 0 0 2 2 2 2 Solute carrier family 12 Sugar_tr PF00083.24 EDN07726.1 - 1.5e-110 370.2 12.7 1.9e-110 369.8 12.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN07726.1 - 5.5e-17 61.7 24.8 1.8e-16 60.0 16.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EDN07726.1 - 4.2e-05 22.1 3.9 4.8e-05 21.9 2.0 1.9 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family UNC-93 PF05978.16 EDN07726.1 - 4.8 6.9 11.8 12 5.6 2.0 3.5 4 0 0 4 4 4 0 Ion channel regulatory protein UNC-93 Pkinase PF00069.25 EDN07727.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Fungal_trans_2 PF11951.8 EDN07729.1 - 3.2e-06 26.2 0.6 0.031 13.1 0.2 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN07729.1 - 9e-06 25.7 8.7 1.7e-05 24.8 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GHMP_kinases_N PF00288.26 EDN07730.1 - 1.3e-16 60.5 0.1 3.9e-16 59.0 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDN07730.1 - 9.6e-08 32.3 0.0 3.5e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 GHMP kinases C terminal PPTA PF01239.22 EDN07731.1 - 1.6e-30 103.9 21.1 5.6e-08 32.3 1.9 5.8 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat Sigma70_ner PF04546.13 EDN07731.1 - 0.033 14.1 6.2 0.05 13.5 2.3 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Cnd2 PF05786.14 EDN07731.1 - 0.15 10.7 6.8 0.21 10.2 2.5 2.0 2 0 0 2 2 2 0 Condensin complex subunit 2 DUF3449 PF11931.8 EDN07731.1 - 3.6 7.3 7.3 0.26 11.0 1.4 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) FAM176 PF14851.6 EDN07731.1 - 4 7.1 6.9 5.2 6.7 1.8 2.3 2 0 0 2 2 2 0 FAM176 family NOA36 PF06524.12 EDN07731.1 - 8.5 5.6 9.7 8.1 5.7 2.4 2.1 2 0 0 2 2 2 0 NOA36 protein PBP1_TM PF14812.6 EDN07731.1 - 9.3 6.7 12.6 6.6 7.2 2.4 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PALP PF00291.25 EDN07732.1 - 3.5e-43 148.1 7.2 3.5e-43 148.1 7.2 2.7 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Anticodon_1 PF08264.13 EDN07733.1 - 1.4e-05 25.1 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDN07733.1 - 0.0081 14.9 0.0 0.018 13.8 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1g PF09334.11 EDN07734.1 - 1.7e-57 194.9 0.1 5.1e-56 190.1 0.1 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDN07734.1 - 3.4e-10 38.8 0.0 1.7e-08 33.2 0.0 2.7 2 1 1 3 3 3 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDN07734.1 - 0.019 14.3 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain NTF2 PF02136.20 EDN07735.1 - 1.6e-08 35.1 0.1 5.8e-08 33.3 0.1 1.8 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 EDN07735.1 - 0.037 14.0 0.0 0.09 12.7 0.0 1.6 2 0 0 2 2 2 0 Nuclear pore RNA shuttling protein Mtr2 Chorion_2 PF03964.15 EDN07735.1 - 0.075 13.9 2.6 4.2 8.3 0.2 2.2 2 0 0 2 2 2 0 Chorion family 2 Glucodextran_B PF09136.10 EDN07735.1 - 0.11 12.9 2.8 0.2 12.1 2.8 1.3 1 0 0 1 1 1 0 Glucodextranase, domain B Ribosomal_60s PF00428.19 EDN07735.1 - 1.5 9.5 12.2 0.21 12.2 5.1 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Ribosomal_L38e PF01781.18 EDN07736.1 - 2.7e-32 110.7 3.0 3.1e-32 110.5 3.0 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Acetyltransf_3 PF13302.7 EDN07737.1 - 7.2e-22 78.5 0.0 4e-21 76.1 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EDN07737.1 - 0.02 14.6 0.2 0.98 9.1 0.1 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN07737.1 - 0.025 14.5 0.8 2.7 8.0 0.0 2.8 3 0 0 3 3 3 0 FR47-like protein DNA_pol_E_B PF04042.16 EDN07738.1 - 9.1e-46 155.9 0.0 1.3e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EDN07738.1 - 1.4e-39 135.2 0.0 2.3e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain PLDc_2 PF13091.6 EDN07739.1 - 1.7e-17 63.6 0.0 9.1e-12 45.0 0.0 2.7 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDN07739.1 - 0.0024 18.0 0.5 0.53 10.6 0.0 3.0 2 0 0 2 2 2 2 Phospholipase D Active site motif NMO PF03060.15 EDN07740.1 - 3.4e-40 138.4 1.3 4.4e-40 138.1 1.3 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 EDN07740.1 - 0.00075 18.6 1.7 0.0011 18.0 1.7 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EDN07740.1 - 0.032 13.2 7.4 0.014 14.4 3.8 1.9 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF1833 PF08875.11 EDN07740.1 - 0.097 12.2 0.0 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1833) Taxilin PF09728.9 EDN07741.1 - 5.2e-91 305.0 50.1 5.2e-91 305.0 50.1 1.4 2 0 0 2 2 2 1 Myosin-like coiled-coil protein ERM PF00769.19 EDN07741.1 - 0.0005 20.0 24.5 0.0005 20.0 24.5 3.5 1 1 1 3 3 3 1 Ezrin/radixin/moesin family SLATT_4 PF18186.1 EDN07741.1 - 0.88 9.2 10.9 0.83 9.3 2.2 2.8 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 DUF4201 PF13870.6 EDN07741.1 - 0.93 9.2 53.9 0.064 13.0 17.7 4.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 EDN07741.1 - 0.93 9.6 53.5 0.15 12.1 14.3 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 EDN07741.1 - 1.4 6.4 51.4 0.097 10.2 44.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) GOLGA2L5 PF15070.6 EDN07741.1 - 1.4 7.5 47.0 0.032 12.9 33.0 2.7 1 1 2 3 3 3 0 Putative golgin subfamily A member 2-like protein 5 TMF_TATA_bd PF12325.8 EDN07741.1 - 4.3 7.6 52.0 1.4 9.2 9.2 4.4 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 EDN07741.1 - 5.2 6.3 45.1 0.17 11.2 8.1 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) EzrA PF06160.12 EDN07741.1 - 5.5 5.0 42.2 0.022 13.0 15.4 2.6 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA DUF812 PF05667.11 EDN07741.1 - 5.7 5.7 51.7 0.17 10.7 22.2 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF812) M16C_assoc PF08367.11 EDN07742.1 - 7.7e-77 257.8 0.1 1.3e-76 257.1 0.1 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EDN07742.1 - 1.1e-19 71.2 0.0 2.1e-12 47.4 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDN07742.1 - 3.3e-11 43.4 0.1 7.2e-10 39.0 0.0 2.8 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) DivIC PF04977.15 EDN07742.1 - 0.089 12.6 1.3 1.5 8.6 0.1 2.8 3 0 0 3 3 3 0 Septum formation initiator Methyltransf_25 PF13649.6 EDN07743.1 - 8.8e-17 61.6 0.0 1.9e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN07743.1 - 2.4e-16 60.2 0.0 5.2e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN07743.1 - 6.6e-15 55.7 0.0 1.2e-14 54.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN07743.1 - 1.8e-14 53.9 0.0 2.4e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN07743.1 - 6.4e-13 48.8 0.0 8.8e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDN07743.1 - 1.2e-07 31.5 0.0 1.7e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 EDN07743.1 - 5.7e-07 29.4 0.0 9.5e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 EDN07743.1 - 8.5e-06 25.3 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EDN07743.1 - 4e-05 22.7 0.0 9.3e-05 21.5 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 EDN07743.1 - 9.7e-05 22.2 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EDN07743.1 - 0.00011 21.6 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DREV PF05219.12 EDN07743.1 - 0.00038 19.6 0.0 0.00056 19.1 0.0 1.4 1 0 0 1 1 1 1 DREV methyltransferase PrmA PF06325.13 EDN07743.1 - 0.0006 19.3 0.0 0.00083 18.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 EDN07743.1 - 0.00074 18.7 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TPMT PF05724.11 EDN07743.1 - 0.0062 16.2 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) FtsJ PF01728.19 EDN07743.1 - 0.017 15.2 0.0 0.066 13.3 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_5 PF01795.19 EDN07743.1 - 0.025 14.1 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family Methyltransf_32 PF13679.6 EDN07743.1 - 0.035 14.1 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EDN07743.1 - 0.04 13.5 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltr_RsmB-F PF01189.17 EDN07743.1 - 0.21 11.2 0.0 1.2 8.7 0.0 2.1 1 1 0 2 2 2 0 16S rRNA methyltransferase RsmB/F tRNA_U5-meth_tr PF05958.11 EDN07743.1 - 0.21 10.5 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase DUF202 PF02656.15 EDN07744.1 - 6e-14 52.2 5.3 6.7e-14 52.1 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF202) RskA PF10099.9 EDN07744.1 - 0.0094 16.3 0.4 0.0094 16.3 0.4 2.3 2 1 0 2 2 2 1 Anti-sigma-K factor rskA Macoilin PF09726.9 EDN07744.1 - 0.26 9.8 0.9 0.37 9.3 0.9 1.1 1 0 0 1 1 1 0 Macoilin family APH PF01636.23 EDN07745.1 - 2.8e-09 37.3 0.0 6.4e-09 36.1 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Cation_efflux PF01545.21 EDN07747.1 - 1e-54 185.3 1.6 2.8e-54 183.9 1.6 1.6 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EDN07747.1 - 0.077 13.1 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter S1-like PF14444.6 EDN07748.1 - 0.0072 16.2 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 S1-like Metallophos PF00149.28 EDN07749.1 - 3.2e-08 34.3 1.1 2.7e-07 31.3 1.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase 4HBT_2 PF13279.6 EDN07750.1 - 6.4e-11 42.8 0.1 7.9e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EDN07750.1 - 0.016 15.5 0.0 0.031 14.6 0.0 1.5 1 0 0 1 1 1 0 Thioesterase superfamily Tyrosinase PF00264.20 EDN07752.1 - 5e-51 174.1 0.1 5e-51 174.1 0.1 1.7 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EDN07752.1 - 2.2e-27 96.2 0.0 4.1e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Tyosinase C-terminal domain Fungal_trans PF04082.18 EDN07753.1 - 4.5e-16 58.7 0.0 6.9e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_S8e PF01201.22 EDN07754.1 - 1.4e-46 158.1 2.5 2e-46 157.6 2.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e CPP1-like PF11833.8 EDN07754.1 - 0.2 11.3 1.1 0.32 10.6 1.1 1.4 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Ribosomal_L21p PF00829.21 EDN07755.1 - 2.3e-10 40.6 0.0 3.6e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.25 EDN07756.1 - 4.6e-48 163.9 0.0 6.1e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07756.1 - 7.3e-18 64.8 0.0 1.1e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EDN07756.1 - 0.00048 19.8 0.7 0.00088 18.9 0.1 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EDN07756.1 - 0.016 15.2 0.1 3 7.7 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EDN07756.1 - 0.06 12.7 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN07756.1 - 0.083 11.6 0.1 0.41 9.4 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 EDN07756.1 - 0.15 11.6 0.0 12 5.5 0.0 2.5 1 1 2 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 PWI PF01480.17 EDN07757.1 - 3e-30 104.3 0.0 4.6e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 PWI domain Peptidase_S64 PF08192.11 EDN07758.1 - 0.022 13.3 0.0 0.031 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S64 BUD22 PF09073.10 EDN07758.1 - 0.27 10.5 0.6 0.49 9.7 0.0 1.6 2 0 0 2 2 2 0 BUD22 Rootletin PF15035.6 EDN07760.1 - 0.0012 19.0 3.3 0.0012 18.9 3.3 1.1 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion UPF0242 PF06785.11 EDN07760.1 - 0.014 15.5 1.8 0.015 15.4 1.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YABBY PF04690.13 EDN07760.1 - 0.039 14.5 0.2 0.043 14.4 0.2 1.1 1 0 0 1 1 1 0 YABBY protein 5_3_exonuc PF01367.20 EDN07760.1 - 0.053 14.1 0.2 0.069 13.8 0.2 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold FAA_hydrolase PF01557.18 EDN07761.1 - 5.5e-54 183.1 0.0 6.3e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Spidroin_N PF16763.5 EDN07762.1 - 0.046 13.7 0.0 0.085 12.9 0.0 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term DUF3584 PF12128.8 EDN07762.1 - 3 5.2 10.5 0.62 7.5 7.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DEAD PF00270.29 EDN07763.1 - 5.6e-45 153.3 1.4 1.1e-44 152.3 1.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN07763.1 - 5.3e-32 110.5 0.5 3.7e-31 107.7 0.1 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07763.1 - 8.6e-07 29.1 0.0 1.5e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDN07763.1 - 4e-05 23.4 0.2 8.1e-05 22.4 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN07763.1 - 0.0011 19.3 2.2 0.0033 17.7 0.8 2.2 2 1 0 2 2 2 1 AAA domain CMS1 PF14617.6 EDN07763.1 - 0.0066 15.8 0.0 0.015 14.7 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 EDN07763.1 - 0.015 15.5 1.1 0.11 12.8 1.1 2.3 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 EDN07763.1 - 0.084 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Helicase Flavi_DEAD PF07652.14 EDN07763.1 - 0.13 12.2 0.2 0.76 9.7 0.2 2.3 1 1 0 1 1 1 0 Flavivirus DEAD domain Cupin_8 PF13621.6 EDN07764.1 - 1.2e-14 54.6 0.0 2.2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EDN07764.1 - 2.5e-07 31.1 0.2 0.0019 18.6 0.0 2.4 2 0 0 2 2 2 2 JmjC domain, hydroxylase F-box-like PF12937.7 EDN07764.1 - 5.9e-06 26.1 0.1 1.3e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN07764.1 - 0.00017 21.4 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 F-box domain Ctr PF04145.15 EDN07765.1 - 2.1e-07 31.7 0.0 2.9e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Ctr copper transporter family NuA4 PF09340.10 EDN07766.1 - 2.6e-27 94.5 0.2 2.6e-27 94.5 0.2 1.8 2 1 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Pinin_SDK_N PF04697.13 EDN07766.1 - 0.024 15.3 7.3 0.66 10.6 1.2 2.3 2 0 0 2 2 2 0 pinin/SDK conserved region SOG2 PF10428.9 EDN07766.1 - 0.12 11.6 8.6 0.13 11.5 8.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Glyco_hydro_38N PF01074.22 EDN07767.1 - 2.1e-87 293.2 0.8 4.7e-87 292.0 0.8 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EDN07767.1 - 2e-55 188.2 0.0 1e-54 185.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EDN07767.1 - 6.9e-27 93.4 0.0 1.5e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EDN07767.1 - 1.6e-11 44.1 0.0 6.2e-11 42.3 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain 7TMR-DISMED2 PF07696.11 EDN07767.1 - 0.015 15.3 0.1 0.28 11.2 0.0 2.5 2 0 0 2 2 2 0 7TMR-DISM extracellular 2 Glyco_hydro_57 PF03065.15 EDN07767.1 - 0.034 13.3 0.0 0.089 12.0 0.0 1.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 57 OPT PF03169.15 EDN07768.1 - 1.9e-75 254.7 44.0 2.8e-75 254.2 44.0 1.2 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3328 PF11807.8 EDN07769.1 - 7.2e-51 173.1 6.6 2.1e-50 171.5 6.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) CBM_26 PF16824.5 EDN07770.1 - 0.094 12.9 1.5 14 5.8 0.2 2.4 1 1 3 4 4 4 0 C-terminal carbohydrate-binding module Chi-conotoxin PF16981.5 EDN07770.1 - 0.44 10.8 3.4 0.69 10.2 0.5 2.3 1 1 2 3 3 3 0 chi-Conotoxin or t superfamily CRA_rpt PF07046.11 EDN07770.1 - 4.9 7.4 11.1 8.1 6.7 2.1 2.7 1 1 2 3 3 3 0 Cytoplasmic repetitive antigen (CRA) like repeat Pro-kuma_activ PF09286.11 EDN07771.1 - 5e-35 120.9 0.0 8e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EDN07771.1 - 6.6e-06 25.6 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Subtilase family DUF3328 PF11807.8 EDN07772.1 - 1.6e-56 191.5 0.5 2e-56 191.2 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.16 EDN07773.1 - 1.1e-18 67.3 22.6 1.1e-14 54.1 11.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN07773.1 - 2.6e-06 26.6 2.6 2.6e-06 26.6 2.6 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter Pro-kuma_activ PF09286.11 EDN07774.1 - 1.2e-34 119.7 0.0 4.9e-34 117.7 0.1 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EDN07774.1 - 2.6e-07 30.2 0.0 4.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Subtilase family CDH-cyt PF16010.5 EDN07775.1 - 1.4e-12 47.7 0.6 2.1e-12 47.1 0.6 1.2 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase DOMON PF03351.17 EDN07775.1 - 0.0031 17.7 0.1 0.0069 16.6 0.1 1.5 1 0 0 1 1 1 1 DOMON domain DUF2427 PF10348.9 EDN07775.1 - 0.043 13.6 0.8 0.1 12.4 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) NUDIX PF00293.28 EDN07777.1 - 1.3e-08 35.0 0.0 2.6e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain PHINT_rpt PF14882.6 EDN07777.1 - 0.084 13.2 0.6 0.2 12.0 0.6 1.6 1 0 0 1 1 1 0 Phage-integrase repeat unit LETM1 PF07766.13 EDN07778.1 - 8.5e-104 346.6 0.2 8.5e-104 346.6 0.2 1.6 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 EDN07778.1 - 0.00014 21.5 0.0 0.0063 16.2 0.0 3.0 3 0 0 3 3 3 1 SAP domain DUF2838 PF10998.8 EDN07779.1 - 2.8e-44 149.9 10.0 2.8e-44 149.9 10.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Val_tRNA-synt_C PF10458.9 EDN07779.1 - 1.1 9.7 6.9 23 5.4 4.6 2.2 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm ABC_tran_Xtn PF12848.7 EDN07779.1 - 2.6 8.1 6.5 0.36 10.9 0.3 2.3 1 1 0 2 2 2 0 ABC transporter Ank_2 PF12796.7 EDN07780.1 - 3.2e-52 175.0 0.2 1.8e-11 44.5 0.0 5.9 3 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN07780.1 - 5.3e-41 138.5 0.6 4.7e-07 30.2 0.0 8.0 7 2 2 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN07780.1 - 1.3e-39 129.7 6.7 0.017 15.6 0.0 11.6 12 0 0 12 12 12 10 Ankyrin repeat Ank_5 PF13857.6 EDN07780.1 - 9.7e-33 111.8 8.1 8.4e-06 26.0 0.2 7.8 5 2 2 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EDN07780.1 - 9.7e-32 108.0 6.3 0.051 14.0 0.0 12.1 12 0 0 12 12 12 8 Ankyrin repeat F-box-like PF12937.7 EDN07780.1 - 0.11 12.4 0.1 0.28 11.1 0.1 1.7 1 0 0 1 1 1 0 F-box-like SMC_N PF02463.19 EDN07781.1 - 2.7e-58 197.0 0.0 1.5e-57 194.6 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDN07781.1 - 2.3e-30 105.3 0.0 8.1e-30 103.5 0.0 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDN07781.1 - 1.4e-11 44.8 6.8 2.7e-05 24.2 0.3 3.3 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDN07781.1 - 3e-07 30.1 0.0 7.3e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain CALCOCO1 PF07888.11 EDN07781.1 - 0.00043 19.3 1.0 0.00043 19.3 1.0 5.2 3 2 2 5 5 5 2 Calcium binding and coiled-coil domain (CALCOCO1) like SbcCD_C PF13558.6 EDN07781.1 - 0.0046 17.2 0.0 0.02 15.1 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit zf-C4H2 PF10146.9 EDN07781.1 - 0.0061 16.9 15.3 0.0061 16.9 15.3 6.7 3 2 4 7 7 7 1 Zinc finger-containing protein ABC_tran PF00005.27 EDN07781.1 - 1.7 9.2 0.0 1.7 9.2 0.0 6.9 4 3 0 4 4 4 0 ABC transporter AAA_22 PF13401.6 EDN07781.1 - 8.6 6.6 8.6 18 5.6 0.0 4.6 4 1 0 4 4 4 0 AAA domain DUF2997 PF11211.8 EDN07783.1 - 0.017 14.9 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Pertussis_S2S3 PF02918.15 EDN07783.1 - 0.032 14.1 0.0 0.29 11.1 0.0 2.1 1 1 1 2 2 2 0 Pertussis toxin, subunit 2 and 3, C-terminal domain Cas_Cas6 PF01881.16 EDN07783.1 - 0.053 14.1 0.0 0.083 13.4 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas6 CLIP_SPH_mas PF18398.1 EDN07783.1 - 0.21 12.0 1.6 0.23 11.9 0.1 1.8 2 0 0 2 2 2 0 Clip-domain serine protease homolog masquerade E3_binding PF02817.17 EDN07784.1 - 1.3e-10 41.4 0.1 3.1e-10 40.2 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain WD40 PF00400.32 EDN07785.1 - 8.1e-25 86.6 13.2 0.00021 22.0 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07785.1 - 2.1e-09 37.5 3.3 0.046 14.0 0.2 4.6 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN07785.1 - 7.5e-06 25.9 0.1 0.024 14.5 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDN07785.1 - 0.048 12.6 0.0 0.12 11.4 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_M18 PF02127.15 EDN07787.1 - 1.7e-152 508.2 0.0 2.6e-152 507.6 0.0 1.2 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) PolC_DP2 PF03833.13 EDN07788.1 - 0.00049 18.1 0.3 0.00069 17.6 0.3 1.1 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 ZapB PF06005.12 EDN07788.1 - 0.01 16.2 3.7 0.024 15.1 3.7 1.6 1 0 0 1 1 1 0 Cell division protein ZapB APG6_N PF17675.1 EDN07788.1 - 0.011 16.3 0.4 0.019 15.5 0.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_13 PF13166.6 EDN07788.1 - 0.046 12.4 0.1 0.066 11.9 0.1 1.1 1 0 0 1 1 1 0 AAA domain YabA PF06156.13 EDN07788.1 - 0.12 13.0 3.4 0.3 11.8 3.4 1.7 1 0 0 1 1 1 0 Initiation control protein YabA CENP-H PF05837.12 EDN07788.1 - 0.17 12.3 4.0 0.42 11.0 4.0 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF5082 PF16888.5 EDN07788.1 - 0.19 12.0 6.5 0.19 12.0 5.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) KASH_CCD PF14662.6 EDN07788.1 - 0.2 11.4 4.6 0.34 10.7 4.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH NRBF2 PF08961.10 EDN07788.1 - 0.27 10.8 7.6 0.28 10.8 3.1 2.2 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Cep57_CLD_2 PF14197.6 EDN07788.1 - 0.46 10.6 3.8 0.21 11.7 1.3 1.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Cnn_1N PF07989.11 EDN07788.1 - 0.57 10.4 5.9 1.2 9.4 1.9 2.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 EDN07788.1 - 0.68 9.7 7.0 1.1 9.0 0.8 2.8 1 1 2 3 3 3 0 Septum formation initiator HSP70 PF00012.20 EDN07789.1 - 1.5e-16 59.7 0.9 1e-12 47.1 0.2 2.1 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EDN07789.1 - 3.9e-05 22.6 0.4 0.02 13.7 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDN07789.1 - 0.044 14.2 3.0 2.2 8.7 1.3 2.9 2 1 0 2 2 2 0 Cell division protein FtsA DUF1746 PF08508.10 EDN07790.1 - 2.9e-43 146.9 2.5 4.4e-43 146.3 2.5 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Requiem_N PF14051.6 EDN07790.1 - 0.0069 16.6 0.1 0.022 15.0 0.0 1.8 1 1 1 2 2 2 1 N-terminal domain of DPF2/REQ. CLP_protease PF00574.23 EDN07791.1 - 2.8e-70 235.9 0.0 3.4e-70 235.6 0.0 1.0 1 0 0 1 1 1 1 Clp protease Clr5 PF14420.6 EDN07791.1 - 0.13 12.5 0.8 0.23 11.7 0.8 1.3 1 0 0 1 1 1 0 Clr5 domain RRG8 PF17068.5 EDN07792.1 - 0.002 17.6 0.1 0.0029 17.0 0.1 1.2 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial ATP-synt_Z PF16594.5 EDN07792.1 - 0.047 13.2 0.1 0.079 12.5 0.1 1.3 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated Hydrolase_6 PF13344.6 EDN07793.1 - 3.4e-29 100.9 0.0 5.2e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN07793.1 - 3.4e-15 55.8 0.0 6.5e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDN07793.1 - 1.1e-09 38.9 0.1 2.7e-08 34.4 0.1 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDN07793.1 - 4.8e-06 26.8 0.6 0.096 12.8 0.0 2.5 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EDN07793.1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) LAGLIDADG_3 PF14528.6 EDN07793.1 - 0.33 11.3 1.4 0.5 10.7 0.2 1.9 2 1 0 2 2 2 0 LAGLIDADG-like domain AAA PF00004.29 EDN07794.1 - 3e-12 47.1 0.0 7.3e-12 45.8 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EDN07794.1 - 2.6e-05 24.6 0.0 4.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_22 PF13401.6 EDN07794.1 - 3e-05 24.3 0.0 0.00021 21.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDN07794.1 - 5.5e-05 23.1 0.2 0.00044 20.1 0.0 2.2 1 1 1 3 3 3 1 AAA domain DNA_pol3_delta2 PF13177.6 EDN07794.1 - 8.3e-05 22.4 0.0 0.0063 16.3 0.0 2.5 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 EDN07794.1 - 0.00012 22.1 0.2 0.03 14.3 0.1 2.9 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN07794.1 - 0.00013 22.4 0.1 0.0045 17.4 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EDN07794.1 - 0.00018 21.5 0.0 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDN07794.1 - 0.0015 18.0 0.1 0.084 12.2 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EDN07794.1 - 0.0016 18.2 0.0 0.0041 16.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDN07794.1 - 0.0041 16.4 0.0 0.0064 15.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 EDN07794.1 - 0.0042 16.9 0.1 0.02 14.6 0.0 2.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EDN07794.1 - 0.0058 17.0 0.0 0.056 13.8 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_7 PF12775.7 EDN07794.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 EDN07794.1 - 0.011 15.6 0.0 0.15 12.0 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDN07794.1 - 0.014 16.0 0.0 0.037 14.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 EDN07794.1 - 0.017 14.9 0.1 0.14 11.9 0.0 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_28 PF13521.6 EDN07794.1 - 0.018 15.3 0.0 0.052 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDN07794.1 - 0.041 13.6 0.0 0.15 11.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 EDN07794.1 - 0.043 13.0 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ResIII PF04851.15 EDN07794.1 - 0.06 13.4 0.0 1.6 8.7 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EDN07794.1 - 0.066 13.7 0.0 0.095 13.2 0.0 1.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN07794.1 - 0.072 13.5 0.0 0.3 11.5 0.0 2.0 2 0 0 2 2 2 0 RNA helicase SNF2_N PF00176.23 EDN07794.1 - 0.086 11.5 0.0 0.24 10.1 0.0 1.6 2 0 0 2 2 2 0 SNF2 family N-terminal domain PhoH PF02562.16 EDN07794.1 - 0.095 12.1 0.0 6.3 6.2 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DUF4863 PF16155.5 EDN07794.1 - 0.1 12.5 0.0 0.57 10.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4863) Rad17 PF03215.15 EDN07794.1 - 0.21 11.5 0.0 0.38 10.7 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain Sec20 PF03908.13 EDN07795.1 - 0.017 15.0 0.2 0.061 13.3 0.2 1.9 1 0 0 1 1 1 0 Sec20 DAGK_cat PF00781.24 EDN07795.1 - 0.34 10.5 1.3 3.3 7.4 0.3 2.3 1 1 1 2 2 2 0 Diacylglycerol kinase catalytic domain OmpH PF03938.14 EDN07795.1 - 0.68 10.3 6.6 0.37 11.1 4.6 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Fungal_lectin_2 PF18647.1 EDN07796.1 - 0.013 16.0 0.0 0.024 15.1 0.0 1.4 1 0 0 1 1 1 0 Alpha-galactosyl-binding fungal lectin DUF4780 PF16012.5 EDN07796.1 - 0.1 12.1 0.0 1.6 8.2 0.0 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4780) Pyrophosphatase PF00719.19 EDN07797.1 - 2.8e-57 193.0 0.1 3.6e-57 192.7 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase HTH_Tnp_Tc5 PF03221.16 EDN07799.1 - 1e-13 51.0 0.8 1.6e-13 50.4 0.3 1.6 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN07799.1 - 0.00028 20.6 0.1 0.00051 19.7 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Chol_subst-bind PF09129.11 EDN07799.1 - 0.0026 16.8 0.1 0.003 16.6 0.1 1.1 1 0 0 1 1 1 1 Cholesterol oxidase, substrate-binding DDE_1 PF03184.19 EDN07800.1 - 3.4e-06 26.8 0.8 8.3e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease UPAR_LY6 PF00021.21 EDN07800.1 - 1 10.1 4.9 1.7 9.4 4.9 1.3 1 0 0 1 1 1 0 u-PAR/Ly-6 domain Dus PF01207.17 EDN07802.1 - 1.1e-44 152.8 0.0 4.8e-44 150.7 0.0 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Peptidase_M28 PF04389.17 EDN07803.1 - 4.5e-39 134.2 0.0 6.3e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDN07803.1 - 3.8e-11 42.9 0.2 1.1e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EDN07803.1 - 4.8e-06 26.4 0.0 8.7e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 SNF2_N PF00176.23 EDN07804.1 - 4e-52 177.1 0.2 6.6e-52 176.4 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN07804.1 - 7.6e-19 68.1 0.1 7.9e-18 64.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07804.1 - 1.1e-09 38.5 0.0 3e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDN07804.1 - 0.00011 22.1 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EDN07804.1 - 0.00016 21.0 0.1 0.00032 20.0 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HIGH_NTase1_ass PF16581.5 EDN07804.1 - 0.0061 16.6 0.2 0.018 15.0 0.2 1.8 1 0 0 1 1 1 1 Cytidyltransferase-related C-terminal region HHH_3 PF12836.7 EDN07804.1 - 0.017 15.4 0.1 0.046 14.0 0.1 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif RSS_P20 PF11757.8 EDN07804.1 - 0.15 12.5 0.5 3.2 8.2 0.5 2.6 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain VMA21 PF09446.10 EDN07805.1 - 3.3e-10 39.9 9.5 5.9e-10 39.1 9.5 1.4 1 1 0 1 1 1 1 VMA21-like domain Ribosomal_L35Ae PF01247.18 EDN07808.1 - 1.9e-29 101.7 0.2 2.2e-29 101.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EDN07808.1 - 0.0056 16.9 0.0 0.12 12.6 0.0 2.1 2 0 0 2 2 2 1 RimM N-terminal domain 2OG-FeII_Oxy PF03171.20 EDN07809.1 - 1.9e-16 60.4 0.0 3.5e-16 59.5 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EDN07809.1 - 0.0033 18.2 0.1 0.0047 17.7 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal RVT_1 PF00078.27 EDN07810.1 - 4.1e-21 75.5 0.0 6.7e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN07810.1 - 3.5e-12 46.7 0.0 7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 RNase H DUF4641 PF15483.6 EDN07812.1 - 0.26 10.4 0.0 0.37 9.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4641) Glyco_hydro_18 PF00704.28 EDN07813.1 - 8.7e-75 252.3 2.6 1.1e-74 252.0 2.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EDN07813.1 - 0.00019 21.9 8.5 0.00039 20.8 8.5 1.6 1 0 0 1 1 1 1 Chitin recognition protein Glyco_hydro_85 PF03644.13 EDN07813.1 - 0.012 15.1 0.1 0.029 13.8 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 Glyco_hydro_114 PF03537.13 EDN07813.1 - 0.014 14.7 0.0 0.098 12.0 0.0 2.4 1 1 0 1 1 1 0 Glycoside-hydrolase family GH114 DUF1708 PF08101.11 EDN07814.1 - 1.5e-174 581.2 0.0 2.8e-174 580.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) YscO-like PF16789.5 EDN07814.1 - 2.7 8.0 8.6 13 5.8 4.0 2.4 2 0 0 2 2 2 0 YscO-like protein Mito_carr PF00153.27 EDN07815.1 - 2.4e-46 155.6 6.6 1.3e-17 63.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1065 PF06358.11 EDN07815.1 - 0.016 15.1 0.0 0.05 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1065) CBS PF00571.28 EDN07816.1 - 0.00029 21.2 0.1 3.8 8.0 0.0 3.4 1 1 2 3 3 3 3 CBS domain MFS_2 PF13347.6 EDN07817.1 - 1.9e-08 33.3 5.4 1.9e-08 33.3 5.4 2.6 2 1 0 2 2 2 1 MFS/sugar transport protein Nuc_H_symport PF03825.16 EDN07817.1 - 0.014 14.4 0.4 0.014 14.4 0.4 3.3 4 1 0 4 4 4 0 Nucleoside H+ symporter DUF3040 PF11239.8 EDN07817.1 - 0.021 15.1 2.3 0.1 12.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) YjcB PF15940.5 EDN07817.1 - 0.037 14.2 0.4 0.037 14.2 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function ABC2_membrane PF01061.24 EDN07818.1 - 1.7e-86 289.0 54.0 9.5e-46 155.9 23.7 3.2 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 EDN07818.1 - 1e-34 118.3 9.6 9.2e-32 108.8 0.0 3.8 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.27 EDN07818.1 - 5.6e-28 98.2 0.0 6.9e-17 62.2 0.0 3.0 3 1 1 4 4 3 2 ABC transporter ABC_trans_N PF14510.6 EDN07818.1 - 5.3e-19 68.6 0.0 1.7e-18 67.0 0.0 1.9 2 0 0 2 2 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EDN07818.1 - 0.00017 20.8 41.0 0.0013 18.0 16.8 3.2 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_18 PF13238.6 EDN07818.1 - 0.00034 21.1 0.0 0.0021 18.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDN07818.1 - 0.00042 20.0 0.0 0.00086 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDN07818.1 - 0.00056 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EDN07818.1 - 0.00067 20.1 0.1 0.0018 18.7 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EDN07818.1 - 0.0054 16.6 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDN07818.1 - 0.0065 15.9 0.0 0.61 9.5 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN07818.1 - 0.0079 15.9 0.1 0.027 14.2 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.6 EDN07818.1 - 0.055 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN07818.1 - 0.11 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDN07818.1 - 0.13 11.9 0.3 0.56 9.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain G6PD_C PF02781.16 EDN07819.1 - 4.9e-115 383.7 0.0 7.3e-115 383.1 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EDN07819.1 - 1.3e-51 175.7 0.0 3.1e-51 174.5 0.0 1.6 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain MFS_1 PF07690.16 EDN07820.1 - 1.1e-45 156.1 46.1 9.2e-45 153.1 45.6 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN07820.1 - 2.4e-24 85.7 15.8 7.3e-24 84.1 15.1 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDN07820.1 - 1.6e-11 43.7 6.5 1.6e-11 43.7 6.5 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter EF-hand_1 PF00036.32 EDN07821.1 - 1.7e-19 67.9 4.9 3.3e-06 26.2 0.2 4.2 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EDN07821.1 - 1.3e-17 62.2 3.1 3.6e-05 23.3 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EDN07821.1 - 4.2e-16 58.5 2.7 2e-06 27.5 0.2 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.6 EDN07821.1 - 4.5e-15 55.9 2.8 4.4e-05 23.9 0.0 3.2 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EDN07821.1 - 3.2e-13 48.5 3.2 8.3e-05 21.9 0.1 4.0 4 0 0 4 4 4 3 EF hand ChaC PF04752.12 EDN07822.1 - 1.2e-18 67.7 0.0 1.8e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 ChaC-like protein RRM_1 PF00076.22 EDN07823.1 - 3.4e-21 74.8 0.0 4.4e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN07823.1 - 0.0023 18.0 0.0 0.0036 17.4 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 EDN07823.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif eIF-5_eIF-2B PF01873.17 EDN07825.1 - 1.6e-40 137.6 0.4 3.2e-40 136.6 0.4 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 GET2 PF08690.10 EDN07825.1 - 0.021 14.5 6.5 0.03 14.0 6.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 TF_Zn_Ribbon PF08271.12 EDN07825.1 - 0.21 11.1 1.8 0.52 9.9 1.8 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding Arc_trans_TRASH PF08394.10 EDN07825.1 - 1.1 9.6 7.6 1.2 9.5 0.4 2.9 1 1 1 2 2 2 0 Archaeal TRASH domain zf-HYPF PF07503.12 EDN07825.1 - 4.8 7.0 6.9 24 4.8 4.1 2.7 2 1 1 3 3 3 0 HypF finger Tyrosinase PF00264.20 EDN07826.1 - 2.6e-35 122.7 1.7 4.3e-35 122.0 1.7 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase AIM24 PF01987.17 EDN07827.1 - 8.9e-55 185.6 0.6 1e-54 185.4 0.6 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 SH3_1 PF00018.28 EDN07828.1 - 1.7e-13 49.9 0.0 2.5e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN07828.1 - 2e-11 43.6 0.0 2.8e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDN07828.1 - 9.9e-08 31.5 0.0 1.5e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain MBF1 PF08523.10 EDN07829.1 - 1.6e-24 86.1 0.4 3.5e-24 85.1 0.0 1.7 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EDN07829.1 - 2.8e-08 33.7 0.1 4.2e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 EDN07829.1 - 0.00045 20.2 0.1 0.00073 19.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 EDN07829.1 - 0.00099 19.4 0.0 0.0021 18.3 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain YdaS_antitoxin PF15943.5 EDN07829.1 - 0.0013 18.5 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT UTP15_C PF09384.10 EDN07830.1 - 0.11 12.2 0.3 2.6 7.7 0.1 2.2 1 1 1 2 2 2 0 UTP15 C terminal Xpo1 PF08389.12 EDN07831.1 - 0.0001 22.4 1.7 0.03 14.4 0.0 3.1 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.19 EDN07831.1 - 0.027 14.4 0.2 0.35 10.8 0.0 2.9 3 1 1 4 4 4 0 Importin-beta N-terminal domain Pkinase PF00069.25 EDN07832.1 - 3.9e-36 124.8 0.6 4.7e-36 124.5 0.6 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07832.1 - 1.2e-22 80.5 0.9 1.5e-22 80.2 0.9 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EDN07832.1 - 0.014 15.0 0.4 0.017 14.7 0.4 1.2 1 0 0 1 1 1 0 RIO1 family Glyco_hydro_5_C PF18564.1 EDN07833.1 - 6e-18 65.2 0.0 1.3e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EDN07833.1 - 4.9e-10 39.3 1.2 2e-07 30.7 0.2 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) TPR_2 PF07719.17 EDN07834.1 - 6e-29 97.8 30.9 0.0028 17.6 0.0 14.6 15 0 0 15 15 15 7 Tetratricopeptide repeat TPR_1 PF00515.28 EDN07834.1 - 1.3e-25 88.1 28.2 0.00051 19.7 0.0 14.5 15 1 0 15 15 15 6 Tetratricopeptide repeat TPR_17 PF13431.6 EDN07834.1 - 6e-24 82.7 0.8 0.03 14.7 0.0 11.4 13 0 0 13 13 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDN07834.1 - 3.5e-22 77.2 23.3 0.025 15.4 0.2 13.4 11 3 3 14 14 13 6 Tetratricopeptide repeat TPR_19 PF14559.6 EDN07834.1 - 4.4e-22 78.4 9.8 0.00044 20.7 0.1 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07834.1 - 5.8e-22 78.1 21.7 1.9e-07 31.6 0.8 9.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07834.1 - 1.8e-21 74.5 25.4 0.3 11.4 0.0 14.9 18 0 0 18 18 16 6 Tetratricopeptide repeat TPR_12 PF13424.6 EDN07834.1 - 4.5e-19 68.5 33.8 0.01 16.1 0.1 12.2 9 4 4 13 13 13 5 Tetratricopeptide repeat TPR_11 PF13414.6 EDN07834.1 - 8.5e-19 67.0 12.6 0.00018 21.1 0.0 10.5 11 0 0 11 11 11 4 TPR repeat TPR_7 PF13176.6 EDN07834.1 - 6.8e-14 50.8 13.8 0.004 17.1 0.0 10.3 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDN07834.1 - 4.5e-11 42.6 23.8 0.84 10.4 0.1 12.8 14 0 0 14 14 13 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN07834.1 - 1.5e-06 28.3 3.6 0.76 10.0 0.0 6.2 6 1 1 7 7 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDN07834.1 - 1.4e-05 25.1 15.4 1.9 8.7 0.1 8.0 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDN07834.1 - 0.00014 21.6 13.3 16 5.6 0.0 9.0 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_22 PF18833.1 EDN07834.1 - 0.0006 19.9 0.0 0.0017 18.5 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN07834.1 - 0.00069 19.1 7.4 0.54 9.6 0.0 4.3 4 0 0 4 4 4 1 MalT-like TPR region Fis1_TPR_C PF14853.6 EDN07834.1 - 0.0048 16.9 0.6 47 4.2 0.0 4.9 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 EDN07834.1 - 0.0071 15.6 14.9 1.2 8.3 0.1 5.6 5 2 1 6 6 6 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EDN07834.1 - 0.013 14.6 0.3 0.52 9.3 0.0 2.3 2 0 0 2 2 2 0 Coatomer WD associated region Coatomer_E PF04733.14 EDN07834.1 - 0.014 14.9 0.8 0.14 11.5 0.0 2.9 2 1 1 3 3 3 0 Coatomer epsilon subunit ChAPs PF09295.10 EDN07834.1 - 0.019 14.0 0.1 15 4.5 0.0 3.8 3 2 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Ribosomal_L12 PF00542.19 EDN07834.1 - 0.1 13.0 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain Vps51 PF08700.11 EDN07835.1 - 1.8e-24 85.6 0.0 3.1e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 EDN07835.1 - 0.011 14.5 0.1 0.014 14.1 0.1 1.1 1 0 0 1 1 1 0 Dor1-like family COG5 PF10392.9 EDN07835.1 - 0.017 15.3 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Golgi transport complex subunit 5 CSN8_PSD8_EIF3K PF10075.9 EDN07837.1 - 5.5e-07 29.7 0.0 9.8e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Pro-kuma_activ PF09286.11 EDN07838.1 - 9.4e-32 110.3 0.0 1.5e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EDN07838.1 - 4.5e-05 22.8 0.0 8.9e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Subtilase family TBCC PF07986.12 EDN07839.1 - 3.3e-34 117.2 1.1 5.6e-34 116.4 1.1 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EDN07839.1 - 2.5e-09 37.6 0.1 4.5e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain PHM7_cyt PF14703.6 EDN07839.1 - 0.0093 16.2 0.1 0.05 13.8 0.1 2.1 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Gag_spuma PF03276.14 EDN07839.1 - 1.1 7.6 6.2 1.6 7.1 6.2 1.1 1 0 0 1 1 1 0 Spumavirus gag protein JAB PF01398.21 EDN07840.1 - 2.6e-15 56.4 0.0 5.2e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 EDN07840.1 - 1.6e-09 38.0 0.1 3e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 EDN07840.1 - 5.7e-05 22.9 0.0 0.00016 21.5 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain RrnaAD PF00398.20 EDN07841.1 - 1.9e-06 27.1 0.0 3.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Pkinase PF00069.25 EDN07842.1 - 4.7e-13 49.1 0.0 8.9e-13 48.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07842.1 - 4.5e-05 22.9 0.0 0.006 15.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EDN07842.1 - 0.0018 18.2 0.0 0.0027 17.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN07842.1 - 0.0053 15.6 0.0 0.0076 15.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase ApbA_C PF08546.11 EDN07843.1 - 1.5e-27 96.3 0.0 3.1e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDN07843.1 - 4.4e-26 91.4 0.0 6.1e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 EDN07843.1 - 0.005 16.2 0.6 0.0083 15.5 0.6 1.3 1 0 0 1 1 1 1 ThiF family PglD_N PF17836.1 EDN07843.1 - 0.02 15.5 0.0 0.048 14.3 0.0 1.6 1 0 0 1 1 1 0 PglD N-terminal domain FAD_binding_3 PF01494.19 EDN07843.1 - 0.066 12.4 0.1 0.087 12.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain WD40 PF00400.32 EDN07846.1 - 5.7e-24 83.9 2.0 1.9e-06 28.5 0.1 6.2 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07846.1 - 1e-10 41.7 0.0 0.15 12.4 0.0 5.0 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN07846.1 - 0.01 15.7 0.2 1.1 9.1 0.0 2.8 2 2 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDN07846.1 - 0.011 14.4 0.1 0.017 13.8 0.1 1.4 1 1 0 1 1 1 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EDN07846.1 - 0.036 13.4 0.0 2.4 7.4 0.0 2.5 2 1 0 2 2 2 0 WD40-like domain PQQ_2 PF13360.6 EDN07846.1 - 0.08 12.5 0.1 0.17 11.5 0.2 1.6 1 1 0 1 1 1 0 PQQ-like domain FTHFS PF01268.19 EDN07847.1 - 2.5e-253 841.4 0.0 3e-253 841.1 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EDN07847.1 - 5.8e-46 155.7 2.3 8.9e-46 155.1 0.3 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EDN07847.1 - 3.8e-37 127.1 0.3 1e-36 125.7 0.3 1.8 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AdoHcyase_NAD PF00670.21 EDN07847.1 - 0.019 15.0 0.8 0.31 11.1 0.2 2.7 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Helicase_C_4 PF13871.6 EDN07847.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue CbiA PF01656.23 EDN07847.1 - 0.14 12.2 0.0 1.4 9.0 0.0 2.6 3 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Iso_dh PF00180.20 EDN07848.1 - 3.5e-43 148.1 0.0 5.2e-33 114.6 0.0 2.2 1 1 1 2 2 2 2 Isocitrate/isopropylmalate dehydrogenase GRIM-19 PF06212.12 EDN07849.1 - 5.7e-12 45.7 0.2 6.3e-12 45.6 0.2 1.0 1 0 0 1 1 1 1 GRIM-19 protein tRNA_m1G_MT PF01746.21 EDN07850.1 - 3.2e-21 75.9 2.5 5.8e-21 75.1 0.0 2.4 2 1 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase NARP1 PF12569.8 EDN07850.1 - 0.39 9.6 6.9 0.74 8.7 6.9 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 VID27 PF08553.10 EDN07851.1 - 2e-99 333.0 1.2 5.4e-90 302.0 0.2 2.2 1 1 1 2 2 2 2 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EDN07851.1 - 2.8e-74 248.7 0.1 2.8e-74 248.7 0.1 3.0 3 1 1 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 EDN07851.1 - 8.1e-48 161.2 2.1 3.2e-47 159.3 1.3 2.1 2 0 0 2 2 2 1 VID27 PH-like domain TLD PF07534.16 EDN07852.1 - 6.4e-25 88.0 0.0 5.5e-15 55.8 0.0 2.4 2 0 0 2 2 2 2 TLD Adaptin_N PF01602.20 EDN07853.1 - 9.5e-130 433.6 1.6 1.1e-129 433.4 1.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDN07853.1 - 9.5e-63 211.1 0.2 1.9e-58 197.1 0.2 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN07853.1 - 5.8e-17 61.9 3.2 1.4e-06 28.6 0.0 5.9 2 1 5 7 7 7 4 HEAT repeats HEAT PF02985.22 EDN07853.1 - 2e-12 46.2 3.1 0.01 16.0 0.0 6.0 6 0 0 6 6 6 3 HEAT repeat Arm PF00514.23 EDN07853.1 - 0.0028 17.6 3.6 3 8.0 0.0 5.0 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDN07853.1 - 0.0075 16.8 7.7 4.1 8.0 0.0 6.7 8 1 1 9 9 9 1 HEAT-like repeat CLASP_N PF12348.8 EDN07853.1 - 0.038 13.6 0.2 4.2 6.9 0.0 3.3 3 1 0 3 3 3 0 CLASP N terminal DEK_C PF08766.11 EDN07854.1 - 0.001 19.0 0.0 0.0032 17.4 0.0 1.9 1 0 0 1 1 1 1 DEK C terminal domain ATHILA PF03078.15 EDN07854.1 - 0.1 11.4 1.2 2.6 6.8 0.0 2.4 2 0 0 2 2 2 0 ATHILA ORF-1 family Evr1_Alr PF04777.13 EDN07855.1 - 1e-08 35.5 1.1 2e-08 34.6 0.1 1.9 2 1 0 2 2 2 1 Erv1 / Alr family Coatomer_WDAD PF04053.14 EDN07856.1 - 2.4e-140 468.5 0.0 3.5e-140 468.0 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EDN07856.1 - 3.4e-107 358.7 0.0 5.2e-107 358.1 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EDN07856.1 - 4.3e-35 119.1 17.1 1.3e-07 32.1 0.3 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07856.1 - 9.1e-07 29.1 0.2 0.19 12.1 0.0 5.2 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN07856.1 - 0.027 13.1 5.9 1.6 7.3 0.1 3.5 2 1 1 4 4 4 0 Nucleoporin Nup120/160 Clathrin PF00637.20 EDN07856.1 - 0.04 13.8 0.3 0.32 10.9 0.0 2.5 3 0 0 3 3 3 0 Region in Clathrin and VPS Phytase-like PF13449.6 EDN07858.1 - 4.2e-37 128.7 0.0 5.7e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Esterase-like activity of phytase Clr5 PF14420.6 EDN07860.1 - 2.2e-19 69.4 0.8 7.9e-19 67.6 0.8 2.1 1 0 0 1 1 1 1 Clr5 domain DUF2407_C PF13373.6 EDN07860.1 - 0.054 13.7 0.4 0.19 11.9 0.1 2.1 2 0 0 2 2 2 0 DUF2407 C-terminal domain DUF3886 PF13025.6 EDN07860.1 - 0.12 12.6 3.9 0.17 12.1 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) Het-C PF07217.11 EDN07861.1 - 4.6e-218 725.3 0.0 8.7e-218 724.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C SAPS PF04499.15 EDN07861.1 - 0.83 8.4 15.5 0.035 12.9 9.4 1.8 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF2828 PF11443.8 EDN07862.1 - 9e-157 522.9 0.8 3.6e-101 339.2 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) Fibrinogen_aC PF12160.8 EDN07862.1 - 0.071 13.0 0.4 4.4 7.2 0.5 2.7 2 0 0 2 2 2 0 Fibrinogen alpha C domain FAD-oxidase_C PF02913.19 EDN07863.1 - 5.3e-61 206.4 0.0 9.8e-61 205.5 0.0 1.4 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDN07863.1 - 2.8e-36 124.3 0.0 5.1e-36 123.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Mannosidase_ig PF17786.1 EDN07864.1 - 2.4e-15 56.9 0.2 6.9e-15 55.4 0.2 1.9 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EDN07864.1 - 5.6e-12 46.3 1.7 1.1e-11 45.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 EDN07864.1 - 7.8e-07 28.8 0.0 2.8e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_N PF02837.18 EDN07864.1 - 0.03 14.2 0.0 0.088 12.7 0.0 1.8 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain Ig_GlcNase PF18368.1 EDN07864.1 - 0.078 13.1 0.9 0.26 11.5 0.0 2.3 3 0 0 3 3 3 0 Exo-beta-D-glucosaminidase Ig-fold domain DDE_1 PF03184.19 EDN07865.1 - 5.2e-19 68.6 0.2 1.9e-18 66.8 0.0 2.0 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN07865.1 - 1.9e-10 40.6 0.2 2.4e-09 37.1 0.0 2.8 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain PFL-like PF02901.15 EDN07865.1 - 0.0072 15.0 0.6 0.013 14.1 0.6 1.4 1 0 0 1 1 1 1 Pyruvate formate lyase-like DDE_3 PF13358.6 EDN07865.1 - 0.087 12.6 0.1 0.4 10.4 0.1 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease P3A PF08727.11 EDN07865.1 - 0.099 12.0 0.0 10 5.6 0.0 2.7 3 0 0 3 3 3 0 Poliovirus 3A protein like ADH_N PF08240.12 EDN07866.1 - 3.6e-32 110.5 0.0 5.9e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN07866.1 - 2e-05 24.6 0.1 3.4e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDN07866.1 - 0.00036 19.9 0.1 0.00049 19.5 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_25 PF13649.6 EDN07866.1 - 0.007 17.0 0.0 0.012 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 EDN07866.1 - 0.013 15.1 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 EDN07866.1 - 0.032 13.6 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EDN07866.1 - 0.076 13.1 0.1 0.23 11.5 0.2 1.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox_2 PF07992.14 EDN07866.1 - 0.11 11.6 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 EDN07866.1 - 0.13 11.8 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus PrmA PF06325.13 EDN07866.1 - 0.19 11.1 0.0 0.27 10.6 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TrkA_N PF02254.18 EDN07866.1 - 0.21 11.9 0.0 0.29 11.4 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Ras PF00071.22 EDN07867.1 - 1.2e-05 24.9 0.0 4.5e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Ras family PAF-AH_p_II PF03403.13 EDN07868.1 - 7e-38 130.1 0.0 1.2e-34 119.4 0.0 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EDN07868.1 - 2.4e-05 23.4 0.2 4.7e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EDN07868.1 - 0.0001 21.5 0.0 0.00018 20.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase Na_Ca_ex PF01699.24 EDN07869.1 - 2.2e-06 27.7 2.5 4.6e-06 26.7 2.5 1.5 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Glyco_tranf_2_3 PF13641.6 EDN07873.1 - 1.5e-28 100.2 0.0 1.9e-28 99.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDN07873.1 - 1.6e-08 34.6 0.0 2.7e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EDN07873.1 - 1.2e-07 31.4 0.0 0.00037 20.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 21 ATP12 PF07542.11 EDN07875.1 - 6.8e-41 139.4 0.2 9.6e-41 138.9 0.2 1.1 1 0 0 1 1 1 1 ATP12 chaperone protein Oxysterol_BP PF01237.18 EDN07876.1 - 4.4e-138 460.2 0.0 1.1e-137 458.9 0.0 1.6 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_5 PF13857.6 EDN07876.1 - 8e-14 51.5 0.6 1.2e-07 31.9 0.1 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EDN07876.1 - 8.4e-14 51.3 0.1 0.00024 21.4 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 EDN07876.1 - 2.4e-13 50.5 0.0 3e-08 34.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN07876.1 - 5.2e-12 44.8 0.1 0.00019 21.6 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EDN07876.1 - 7e-12 45.6 0.1 3.1e-06 27.6 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) PH PF00169.29 EDN07876.1 - 2.1e-07 31.4 0.1 4.3e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EDN07876.1 - 2.6e-05 24.6 1.6 4.1e-05 23.9 0.5 2.0 2 0 0 2 2 1 1 Pleckstrin homology domain PH_8 PF15409.6 EDN07876.1 - 0.00029 21.1 0.2 0.00073 19.8 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain LLC1 PF14945.6 EDN07876.1 - 0.0027 18.3 0.5 0.0096 16.5 0.5 1.9 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein ERM PF00769.19 EDN07876.1 - 9 6.0 13.8 0.034 14.0 3.3 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family zf-Mss51 PF13824.6 EDN07877.1 - 1.3e-27 95.6 6.3 1.3e-27 95.6 6.3 2.2 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EDN07877.1 - 0.039 14.1 0.5 0.039 14.1 0.5 2.2 3 0 0 3 3 3 0 MYND finger ADH_zinc_N PF00107.26 EDN07879.1 - 1.4e-28 99.4 0.8 2e-28 98.9 0.8 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN07879.1 - 3e-05 23.8 0.0 0.0001 22.2 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDN07879.1 - 0.0057 17.7 0.0 0.012 16.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EDN07879.1 - 0.038 13.5 0.2 0.055 12.9 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.18 EDN07879.1 - 0.1 12.9 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain HupF_HypC PF01455.18 EDN07879.1 - 0.11 12.6 0.5 0.66 10.2 0.1 2.3 2 0 0 2 2 2 0 HupF/HypC family HET PF06985.11 EDN07881.1 - 3.7e-30 105.2 0.0 6.2e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Clr5 PF14420.6 EDN07882.1 - 6.1e-13 48.8 0.5 1e-12 48.1 0.5 1.4 1 0 0 1 1 1 1 Clr5 domain SNF2_N PF00176.23 EDN07883.1 - 3.7e-42 144.3 1.8 3.7e-42 144.3 1.8 2.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN07883.1 - 1.2e-07 32.1 0.2 8.9e-07 29.2 0.3 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EDN07883.1 - 1.2e-07 31.9 10.4 1.2e-07 31.9 10.4 2.4 2 0 0 2 2 2 1 HSA ResIII PF04851.15 EDN07883.1 - 2.6e-05 24.3 0.1 0.0016 18.5 0.0 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit RsbRD_N PF14361.6 EDN07883.1 - 1 10.1 6.9 54 4.5 6.1 3.0 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain NDUF_B8 PF05821.11 EDN07884.1 - 7.1e-07 29.2 0.5 9.6e-07 28.8 0.5 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Membr_traf_MHD PF10540.9 EDN07886.1 - 7.9e-19 68.3 0.2 6.3e-16 58.9 0.2 2.7 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EDN07886.1 - 9.1e-16 58.0 0.0 2.1e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain Ribonuc_L-PSP PF01042.21 EDN07887.1 - 3.1e-40 137.0 0.0 3.3e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP MFS_1 PF07690.16 EDN07889.1 - 6.9e-26 91.0 21.3 4.6e-25 88.3 21.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_47 PF01532.20 EDN07890.1 - 1.1e-111 374.0 0.0 1.5e-111 373.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MRAP PF15183.6 EDN07891.1 - 0.11 12.5 0.7 0.19 11.7 0.7 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family CCSMST1 PF15013.6 EDN07891.1 - 0.18 12.0 0.3 0.35 11.1 0.3 1.5 1 0 0 1 1 1 0 CCSMST1 family WD40 PF00400.32 EDN07892.1 - 1.2e-38 130.4 9.8 5.1e-06 27.1 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN07892.1 - 3.1e-11 43.4 0.1 0.002 18.4 0.0 4.3 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN07892.1 - 0.073 12.0 0.0 9 5.1 0.0 2.8 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EDN07892.1 - 0.25 10.0 0.7 7.7 5.1 0.1 2.5 2 1 0 2 2 2 0 Nup133 N terminal like TRAPP PF04051.16 EDN07893.1 - 5.6e-37 126.7 0.0 6.8e-37 126.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component EGL-1 PF11430.8 EDN07893.1 - 0.016 15.0 0.1 0.87 9.5 0.0 2.4 2 0 0 2 2 2 0 Programmed cell death activator EGL-1 DUF4250 PF14056.6 EDN07893.1 - 0.026 14.5 0.1 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) PNGaseA PF12222.8 EDN07893.1 - 0.045 12.6 0.0 0.057 12.3 0.0 1.1 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A LisH PF08513.11 EDN07894.1 - 0.00015 21.5 0.2 0.00029 20.7 0.2 1.4 1 0 0 1 1 1 1 LisH DND1_DSRM PF14709.7 EDN07898.1 - 0.001 19.3 1.1 0.0072 16.6 0.3 2.8 2 2 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_1 PF00076.22 EDN07900.1 - 2e-44 149.3 0.0 8e-17 60.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDN07900.1 - 3.8e-05 23.6 0.1 0.0016 18.4 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EDN07900.1 - 0.00022 21.2 0.0 0.0013 18.8 0.0 2.1 3 0 0 3 3 3 1 RNA binding motif RRM_occluded PF16842.5 EDN07900.1 - 0.00064 19.5 0.0 0.061 13.2 0.0 2.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EDN07900.1 - 0.00093 19.3 0.2 0.054 13.6 0.0 2.8 3 1 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 EDN07900.1 - 0.01 15.4 0.0 0.052 13.2 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UPF0154 PF03672.13 EDN07900.1 - 0.011 15.7 1.6 0.48 10.5 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) PHM7_cyt PF14703.6 EDN07900.1 - 0.27 11.5 0.1 26 5.0 0.0 3.5 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter TFB6 PF17110.5 EDN07902.1 - 1.4e-43 148.6 0.0 7.7e-43 146.2 0.0 2.0 1 1 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH RRM_Rrp7 PF17799.1 EDN07903.1 - 1.3e-32 112.8 0.0 2.1e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 EDN07903.1 - 1.1e-27 96.5 9.7 2.2e-27 95.6 9.7 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 EDN07903.1 - 0.12 12.2 0.1 4.4 7.2 0.0 2.9 4 0 0 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad51 PF08423.11 EDN07904.1 - 1.7e-107 358.4 0.3 5.5e-106 353.5 0.3 2.1 1 1 0 1 1 1 1 Rad51 RecA PF00154.21 EDN07904.1 - 2.7e-10 40.2 0.0 3.6e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EDN07904.1 - 5.6e-08 33.3 1.3 9.7e-08 32.5 0.3 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EDN07904.1 - 7.3e-06 25.5 0.0 1.9e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EDN07904.1 - 4.6e-05 23.1 0.0 7.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain NRD1_2 PF01995.16 EDN07904.1 - 0.03 13.6 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 AAA_24 PF13479.6 EDN07904.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain zf-CCHC PF00098.23 EDN07905.1 - 4e-30 102.5 37.2 9e-08 31.9 1.0 6.2 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_3 PF13917.6 EDN07905.1 - 4.9e-07 29.6 17.2 0.096 12.7 0.0 5.2 4 1 1 5 5 5 4 Zinc knuckle zf-CCHC_4 PF14392.6 EDN07905.1 - 3e-06 26.9 26.7 0.17 11.6 0.3 6.0 6 0 0 6 6 6 4 Zinc knuckle zf-CCHC_5 PF14787.6 EDN07905.1 - 0.0021 17.7 28.1 0.011 15.5 0.9 5.6 4 1 2 6 6 6 3 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 EDN07905.1 - 0.19 11.6 0.5 0.19 11.6 0.5 5.2 5 0 0 5 5 5 0 Zinc knuckle TRAF6_Z2 PF18048.1 EDN07905.1 - 0.87 9.7 14.1 0.89 9.7 0.1 4.5 4 1 1 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 UDPGP PF01704.18 EDN07906.1 - 6e-55 186.6 0.0 8e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Pro_isomerase PF00160.21 EDN07907.1 - 9.6e-35 120.2 0.0 1.3e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EDN07907.1 - 4.6e-16 58.4 0.0 9.7e-16 57.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDN07907.1 - 0.18 11.8 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribosomal_S24e PF01282.19 EDN07908.1 - 1.7e-34 117.6 0.5 2.7e-34 117.0 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e RRXRR PF14239.6 EDN07908.1 - 0.005 16.7 1.8 0.0057 16.5 1.8 1.2 1 0 0 1 1 1 1 RRXRR protein FAD_binding_4 PF01565.23 EDN07908.1 - 0.19 11.5 0.0 0.24 11.1 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Methyltransf_16 PF10294.9 EDN07909.1 - 5e-12 45.9 0.0 7.8e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EDN07909.1 - 0.00013 21.5 0.0 0.00019 21.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDN07909.1 - 0.00054 19.6 0.0 0.00099 18.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDN07909.1 - 0.00074 20.2 0.0 0.0013 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN07909.1 - 0.0025 18.5 0.0 0.0057 17.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN07909.1 - 0.0098 15.7 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EDN07909.1 - 0.013 14.6 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF938 PF06080.12 EDN07909.1 - 0.026 14.3 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) FPP PF05911.11 EDN07910.1 - 0.04 12.1 17.7 0.076 11.2 17.7 1.4 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Fib_alpha PF08702.10 EDN07910.1 - 2.3 8.4 18.3 0.67 10.1 3.1 3.1 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family Cob_adeno_trans PF01923.18 EDN07910.1 - 2.7 8.1 7.2 6 7.0 6.7 1.8 1 1 0 1 1 1 0 Cobalamin adenosyltransferase DivIVA PF05103.13 EDN07910.1 - 4.5 7.4 19.8 6.3 6.9 0.0 3.4 2 1 0 2 2 2 0 DivIVA protein PET117 PF15786.5 EDN07911.1 - 1.6e-23 82.7 1.0 1.9e-23 82.5 1.0 1.1 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial V-ATPase_G PF03179.15 EDN07912.1 - 1.3e-27 96.4 12.3 1.5e-27 96.2 12.3 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DXP_synthase_N PF13292.6 EDN07912.1 - 0.0097 15.1 0.1 0.012 14.9 0.1 1.1 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase AAA_15 PF13175.6 EDN07912.1 - 0.024 14.3 4.2 0.026 14.2 4.2 1.0 1 0 0 1 1 1 0 AAA ATPase domain DUF2203 PF09969.9 EDN07912.1 - 0.04 14.6 4.2 0.049 14.4 4.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) HypD PF01924.16 EDN07912.1 - 0.12 11.5 1.7 0.13 11.3 1.7 1.0 1 0 0 1 1 1 0 Hydrogenase formation hypA family ATP-synt_B PF00430.18 EDN07912.1 - 0.64 10.1 15.5 0.49 10.5 9.1 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) V-ATPase_G_2 PF16999.5 EDN07912.1 - 0.73 10.3 12.7 4.7 7.7 12.7 2.0 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF883 PF05957.13 EDN07912.1 - 2.9 8.6 6.8 4.4 8.0 6.7 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF5446 PF17522.2 EDN07912.1 - 6.8 6.9 8.3 1.7 8.9 4.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5446) Arrestin_N PF00339.29 EDN07914.1 - 2.5e-09 37.3 0.0 3.2e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain BING4CT PF08149.11 EDN07914.1 - 0.078 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 BING4CT (NUC141) domain DASH_Dad1 PF08649.10 EDN07915.1 - 0.25 11.6 0.9 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad1 Macoilin PF09726.9 EDN07915.1 - 1 7.8 22.3 2.1 6.8 22.3 1.5 1 0 0 1 1 1 0 Macoilin family Pyr_redox_2 PF07992.14 EDN07916.1 - 3.1e-47 161.2 0.1 4.1e-47 160.8 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EDN07916.1 - 5.4e-15 55.1 0.0 1.1e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EDN07916.1 - 5.4e-14 52.5 1.0 2.8e-11 43.8 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN07916.1 - 5.4e-08 32.5 0.0 0.00018 20.9 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EDN07916.1 - 5e-06 27.0 0.0 1.4e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal Rieske_2 PF13806.6 EDN07916.1 - 0.00033 20.5 0.0 0.00097 19.0 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain NAD_binding_9 PF13454.6 EDN07916.1 - 0.00052 20.0 0.2 0.81 9.7 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EDN07916.1 - 0.00054 19.2 0.1 0.42 9.7 0.0 2.4 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DUF1188 PF06690.11 EDN07916.1 - 0.002 17.7 0.1 0.0034 17.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) TrkA_N PF02254.18 EDN07916.1 - 0.017 15.4 2.0 1.2 9.4 0.2 2.6 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.14 EDN07916.1 - 0.021 13.5 0.2 6.5 5.3 0.0 3.0 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_7 PF13241.6 EDN07916.1 - 0.075 13.5 0.1 0.52 10.8 0.0 2.1 1 1 1 2 2 2 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 EDN07916.1 - 0.18 12.1 1.0 2.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EDN07916.1 - 0.2 11.2 1.9 1.7 8.1 0.9 2.9 2 1 0 2 2 2 0 FAD dependent oxidoreductase RPA43_OB PF17875.1 EDN07917.1 - 6.7e-39 133.3 0.0 6.7e-39 133.3 0.0 3.8 3 1 0 3 3 3 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EDN07917.1 - 1e-05 25.8 0.0 2.2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DnaJ PF00226.31 EDN07918.1 - 1.9e-11 43.9 0.0 5.1e-11 42.5 0.0 1.8 1 1 0 1 1 1 1 DnaJ domain DUF2633 PF11119.8 EDN07918.1 - 0.085 12.8 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) SPRY PF00622.28 EDN07919.1 - 3.4e-20 72.4 0.4 5.1e-20 71.8 0.4 1.3 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 EDN07919.1 - 3.6e-14 52.9 0.0 7.5e-14 51.9 0.0 1.5 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EDN07919.1 - 0.019 14.9 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 LisH SDA1 PF05285.12 EDN07919.1 - 5.9 6.2 7.1 9.5 5.5 7.1 1.3 1 0 0 1 1 1 0 SDA1 Glyco_hydro_16 PF00722.21 EDN07921.1 - 9.4e-05 22.0 0.2 0.00015 21.3 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 IDO PF01231.18 EDN07922.1 - 5.7e-24 84.7 0.0 2.1e-20 73.0 0.0 2.3 2 1 0 2 2 2 2 Indoleamine 2,3-dioxygenase LRR_4 PF12799.7 EDN07923.1 - 2.8e-05 24.4 15.6 0.038 14.4 0.1 6.4 3 3 4 7 7 7 2 Leucine Rich repeats (2 copies) TPR_2 PF07719.17 EDN07923.1 - 0.00017 21.4 2.4 0.4 10.9 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDN07923.1 - 0.00043 20.0 0.2 0.046 13.6 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDN07923.1 - 0.0011 19.2 1.3 0.68 10.3 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat LRR_6 PF13516.6 EDN07923.1 - 0.052 13.6 4.8 3.5 7.9 0.4 4.5 4 0 0 4 4 4 0 Leucine Rich repeat TPR_3 PF07720.12 EDN07923.1 - 0.13 12.3 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat FNIP PF05725.12 EDN07923.1 - 0.14 12.4 3.4 9.3 6.5 0.6 4.3 4 2 0 4 4 3 0 FNIP Repeat LRR_8 PF13855.6 EDN07923.1 - 0.15 11.9 9.0 2.7 7.8 0.0 5.2 6 1 0 6 6 6 0 Leucine rich repeat TPR_8 PF13181.6 EDN07923.1 - 0.19 12.0 1.4 3.5 8.1 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN07923.1 - 0.19 12.0 1.5 0.99 9.7 1.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDN07923.1 - 0.3 11.3 1.8 7.4 6.8 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDN07923.1 - 0.46 10.6 3.2 1.6 9.0 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN07923.1 - 0.62 11.0 3.3 13 6.9 0.5 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN07923.1 - 0.96 10.2 6.4 2.3 9.1 0.4 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_1 PF00560.33 EDN07923.1 - 2.8 8.8 12.3 2.5 9.0 0.1 5.2 6 0 0 6 6 5 0 Leucine Rich Repeat ADIP PF11559.8 EDN07924.1 - 8.8e-28 97.3 17.0 8.8e-28 97.3 17.0 3.8 4 2 0 4 4 4 1 Afadin- and alpha -actinin-Binding Nucleopor_Nup85 PF07575.13 EDN07927.1 - 6e-25 87.9 0.0 8.6e-19 67.5 0.0 2.3 2 0 0 2 2 2 2 Nup85 Nucleoporin DUF3425 PF11905.8 EDN07929.1 - 5.1e-11 42.6 0.4 2.5e-10 40.4 0.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) Fungal_trans PF04082.18 EDN07929.1 - 0.0067 15.5 0.1 0.012 14.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain AMPK1_CBM PF16561.5 EDN07930.1 - 0.018 15.2 0.0 0.037 14.2 0.0 1.4 1 1 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase RNA_pol_Rpb2_6 PF00562.28 EDN07931.1 - 4.1e-124 414.6 0.1 6.2e-124 414.0 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDN07931.1 - 2e-60 203.8 0.0 3.8e-60 202.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDN07931.1 - 7.3e-48 162.7 0.0 1.5e-47 161.7 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDN07931.1 - 8e-34 115.9 0.0 1.7e-33 114.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EDN07931.1 - 1.8e-25 88.9 0.1 4.7e-25 87.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EDN07931.1 - 5.2e-25 87.5 0.9 1.5e-24 86.1 0.9 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EDN07931.1 - 4.5e-23 81.6 0.3 2.1e-22 79.4 0.3 2.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Mo25 PF08569.11 EDN07931.1 - 0.044 13.2 0.2 0.094 12.1 0.2 1.5 1 0 0 1 1 1 0 Mo25-like GLTP PF08718.11 EDN07931.1 - 0.14 12.4 0.1 0.32 11.3 0.1 1.5 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) MRNIP PF15749.5 EDN07931.1 - 0.18 12.6 0.1 0.58 10.9 0.1 1.9 1 0 0 1 1 1 0 MRN-interacting protein Tom6 PF17112.5 EDN07932.1 - 0.00034 20.1 0.2 0.00054 19.4 0.2 1.6 1 1 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal adh_short PF00106.25 EDN07933.1 - 4.9e-31 107.7 0.0 6.3e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN07933.1 - 7.6e-23 81.3 0.0 1e-22 80.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N PF00107.26 EDN07933.1 - 0.0018 18.2 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF294 PF03445.13 EDN07933.1 - 0.022 14.6 0.1 0.038 13.8 0.1 1.4 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 KR PF08659.10 EDN07933.1 - 0.17 11.8 0.1 0.36 10.7 0.1 1.6 1 1 0 1 1 1 0 KR domain 2-Hacid_dh_C PF02826.19 EDN07933.1 - 0.18 11.1 0.0 1.2 8.5 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1776 PF08643.10 EDN07933.1 - 0.2 11.0 0.0 0.29 10.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) RNB PF00773.19 EDN07934.1 - 3.1e-37 128.7 0.0 5.3e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 RNB domain MARVEL PF01284.23 EDN07935.1 - 9.7e-06 25.7 4.3 1.2e-05 25.3 4.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain CytB6-F_Fe-S PF08802.10 EDN07935.1 - 0.069 13.2 0.7 0.2 11.7 0.7 1.8 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit ABC2_membrane_5 PF13346.6 EDN07935.1 - 0.16 11.5 8.4 0.47 10.0 8.4 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein ABC_cobalt PF09819.9 EDN07935.1 - 0.28 11.3 6.5 1.2 9.2 6.5 2.0 1 1 0 1 1 1 0 ABC-type cobalt transport system, permease component Papilloma_E5 PF03025.14 EDN07935.1 - 0.6 10.3 8.4 0.11 12.7 4.6 1.7 2 0 0 2 2 2 0 Papillomavirus E5 DUF4229 PF14012.6 EDN07935.1 - 6.1 7.0 8.7 2.3 8.4 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4229) Ras PF00071.22 EDN07936.1 - 0.00018 21.1 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Ras family MAPEG PF01124.18 EDN07937.1 - 8.7e-17 61.2 1.8 1e-16 61.1 1.8 1.1 1 0 0 1 1 1 1 MAPEG family DPPIV_N PF00930.21 EDN07939.1 - 2.4e-112 375.2 2.3 3.4e-112 374.7 2.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EDN07939.1 - 9.6e-41 139.6 0.9 1.7e-40 138.8 0.9 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EDN07939.1 - 0.00017 22.3 0.3 0.0022 18.6 0.0 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family PD40 PF07676.12 EDN07939.1 - 0.0085 16.0 0.2 0.49 10.4 0.1 3.0 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Abhydrolase_1 PF00561.20 EDN07939.1 - 0.045 13.4 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 EDN07939.1 - 0.047 12.3 0.1 0.32 9.6 0.0 2.2 3 0 0 3 3 3 0 Acetyl xylan esterase (AXE1) Mannosyl_trans3 PF11051.8 EDN07940.1 - 3.6e-60 203.6 0.0 4.1e-35 121.5 0.0 2.3 1 1 1 2 2 2 2 Mannosyltransferase putative ABC2_membrane PF01061.24 EDN07941.1 - 1.3e-30 106.4 32.0 1.8e-30 106.0 32.0 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EDN07941.1 - 2.2e-26 93.0 0.0 4.3e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDN07941.1 - 1.5e-05 25.0 0.1 0.12 12.2 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDN07941.1 - 2.1e-05 25.0 0.0 0.00011 22.7 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDN07941.1 - 2.5e-05 24.2 0.1 5.2e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_13 PF13166.6 EDN07941.1 - 6.3e-05 21.8 0.1 0.0064 15.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDN07941.1 - 0.0008 19.0 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EDN07941.1 - 0.0014 18.2 0.0 0.0028 17.2 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EDN07941.1 - 0.0022 18.2 0.0 0.0046 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDN07941.1 - 0.0027 18.2 0.1 0.014 15.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN07941.1 - 0.0031 17.8 0.0 0.0095 16.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN07941.1 - 0.0036 17.1 0.0 0.0066 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDN07941.1 - 0.0058 16.6 0.1 0.012 15.5 0.0 1.5 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EDN07941.1 - 0.0066 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 EDN07941.1 - 0.011 16.1 0.4 0.069 13.6 0.1 2.3 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDN07941.1 - 0.016 15.2 0.0 0.073 13.0 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_33 PF13671.6 EDN07941.1 - 0.02 15.0 0.1 0.042 14.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDN07941.1 - 0.025 14.5 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EDN07941.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EDN07941.1 - 0.052 13.3 0.0 0.093 12.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 EDN07941.1 - 0.061 12.4 0.0 0.099 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 EDN07941.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 EDN07941.1 - 0.088 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SMC_N PF02463.19 EDN07941.1 - 0.093 12.1 0.1 10 5.5 0.0 2.4 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDN07941.1 - 0.097 12.8 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EDN07941.1 - 0.11 11.6 0.1 0.34 10.1 0.1 1.8 1 1 1 2 2 2 0 NB-ARC domain PduV-EutP PF10662.9 EDN07941.1 - 0.12 12.1 0.0 0.4 10.4 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 EDN07941.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EDN07941.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_23 PF13476.6 EDN07941.1 - 0.16 12.5 2.3 0.23 12.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN07941.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.7 EDN07941.1 - 1.5 7.9 32.9 0.58 9.2 29.6 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein Fungal_trans PF04082.18 EDN07942.1 - 1.3e-09 37.5 0.0 2.1e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain GFA PF04828.14 EDN07943.1 - 1.6e-24 86.1 0.7 1.6e-24 86.1 0.7 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme INPP5B_PH PF16776.5 EDN07943.1 - 0.017 14.9 0.0 0.023 14.4 0.0 1.1 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Zn_ribbon_SprT PF17283.2 EDN07943.1 - 0.072 13.0 12.4 0.38 10.7 1.8 2.6 2 1 0 2 2 2 0 SprT-like zinc ribbon domain Cys_Met_Meta_PP PF01053.20 EDN07945.1 - 1.1e-58 198.7 0.0 3.2e-58 197.1 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDN07945.1 - 0.0016 17.7 0.0 0.0029 16.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDN07945.1 - 0.0057 15.6 0.0 0.0099 14.9 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDN07945.1 - 0.017 14.5 0.1 0.27 10.5 0.0 2.4 3 0 0 3 3 3 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3665 PF12427.8 EDN07946.1 - 0.15 11.8 3.4 0.34 10.6 3.4 1.6 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase TRP PF06011.12 EDN07947.1 - 9.1e-38 130.1 19.5 1.5e-35 122.8 19.5 2.2 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDN07947.1 - 2.4e-17 63.6 0.0 4.1e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 ML-like domain Stevor PF17410.2 EDN07947.1 - 0.54 9.8 1.2 1.1 8.8 1.2 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame QWRF PF04484.12 EDN07947.1 - 4.4 7.0 6.0 9.5 5.9 6.0 1.5 1 0 0 1 1 1 0 QWRF family FYVE PF01363.21 EDN07948.1 - 1.4e-19 70.0 3.5 1.4e-19 70.0 3.5 3.0 3 0 0 3 3 3 1 FYVE zinc finger Zn_clus PF00172.18 EDN07948.1 - 5.5e-05 23.2 12.1 5.5e-05 23.2 12.1 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDN07948.1 - 0.00052 19.1 0.0 0.0014 17.7 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-RING_11 PF17123.5 EDN07948.1 - 0.014 15.2 0.6 0.053 13.3 0.6 2.1 1 0 0 1 1 1 0 RING-like zinc finger Zn-C2H2_12 PF18112.1 EDN07948.1 - 0.26 11.8 3.2 2.1 8.9 0.1 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain NAD_binding_10 PF13460.6 EDN07949.1 - 6.5e-05 22.9 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDN07949.1 - 0.00011 21.8 0.0 0.00017 21.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EDN07949.1 - 0.024 13.8 0.0 0.71 9.0 0.0 2.5 3 0 0 3 3 3 0 Male sterility protein Semialdhyde_dh PF01118.24 EDN07949.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 EDN07950.1 - 3.9e-13 49.1 21.7 3.9e-13 49.1 21.7 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily TMEM208_SND2 PF05620.11 EDN07950.1 - 0.11 12.2 0.5 0.4 10.5 0.5 1.9 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Amidase PF01425.21 EDN07951.1 - 4.9e-76 256.5 0.0 1.2e-75 255.2 0.0 1.7 1 1 0 1 1 1 1 Amidase zf-CCCH PF00642.24 EDN07953.1 - 7e-08 32.2 20.0 4.2e-07 29.7 2.5 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDN07953.1 - 0.008 16.2 3.3 0.008 16.2 3.3 3.3 3 0 0 3 3 3 1 Zinc finger domain RRM_1 PF00076.22 EDN07953.1 - 0.016 15.0 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EDN07953.1 - 0.018 15.7 2.7 0.66 10.7 0.1 2.5 2 0 0 2 2 2 0 Torus domain UDPGP PF01704.18 EDN07957.1 - 9e-191 633.9 0.0 1e-190 633.7 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase RRM_1 PF00076.22 EDN07958.1 - 1.2e-16 60.3 0.0 3.7e-12 45.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN07958.1 - 0.0022 17.6 0.0 0.82 9.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) C2 PF00168.30 EDN07959.1 - 3.9e-76 251.9 0.0 2.5e-20 72.7 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 EDN07959.1 - 0.0013 18.2 0.0 0.0037 16.7 0.0 1.6 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain Integrin_b_cyt PF08725.11 EDN07959.1 - 0.17 11.6 0.1 0.62 9.8 0.1 2.0 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain MFS_1 PF07690.16 EDN07960.1 - 4.1e-10 39.1 14.8 4.1e-10 39.1 14.8 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2512 PF10710.9 EDN07960.1 - 5.2 6.7 7.5 0.91 9.2 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2512) Phage_holin_3_3 PF16083.5 EDN07960.1 - 6.2 7.0 10.6 3.6 7.8 2.3 3.3 3 0 0 3 3 3 0 LydA holin phage, holin superfamily III TPR_1 PF00515.28 EDN07961.1 - 1.4e-40 135.4 19.3 8.4e-05 22.2 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 EDN07961.1 - 6.7e-38 128.4 8.5 6.5e-22 77.2 0.4 3.0 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 EDN07961.1 - 1.9e-29 99.4 25.1 0.00017 21.4 0.0 10.0 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_11 PF13414.6 EDN07961.1 - 6.4e-19 67.4 16.5 0.0018 17.9 0.2 7.8 6 2 2 8 8 8 5 TPR repeat TPR_19 PF14559.6 EDN07961.1 - 3.3e-14 53.1 17.1 0.0066 16.9 0.1 7.4 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDN07961.1 - 3.3e-14 51.8 24.8 0.036 14.3 0.0 9.0 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDN07961.1 - 1.9e-12 47.6 11.1 0.031 14.9 0.1 5.6 6 0 0 6 6 4 4 Tetratricopeptide repeat TPR_9 PF13371.6 EDN07961.1 - 3.1e-10 40.0 2.9 0.0016 18.5 0.0 4.0 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDN07961.1 - 2e-09 36.8 4.1 0.011 15.7 0.0 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDN07961.1 - 3e-09 36.9 16.6 0.55 11.2 0.1 8.6 7 3 4 11 11 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN07961.1 - 8.8e-09 35.5 14.4 0.00014 22.0 0.0 6.2 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDN07961.1 - 1.5e-07 31.3 6.8 1.5 9.3 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDN07961.1 - 2.2e-05 24.8 15.7 2.4 9.0 0.0 8.2 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN07961.1 - 0.00017 21.8 2.8 0.25 11.6 0.1 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EDN07961.1 - 0.0014 18.4 11.1 0.11 12.4 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDN07961.1 - 0.0082 16.2 3.2 1 9.5 0.0 4.7 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat Inhibitor_I9 PF05922.16 EDN07961.1 - 0.047 14.4 0.0 0.15 12.7 0.0 1.9 1 0 0 1 1 1 0 Peptidase inhibitor I9 ProQ PF04352.13 EDN07961.1 - 0.11 12.4 3.8 0.22 11.4 1.3 2.5 2 0 0 2 2 2 0 ProQ/FINO family Alkyl_sulf_dimr PF14863.6 EDN07961.1 - 0.13 12.7 9.3 18 5.8 0.0 4.0 3 2 0 3 3 3 0 Alkyl sulfatase dimerisation DUF5486 PF17588.2 EDN07961.1 - 0.42 10.5 2.2 0.77 9.7 1.0 2.1 2 0 0 2 2 1 0 Family of unknown function (DUF5486) TPR_3 PF07720.12 EDN07961.1 - 0.7 10.0 10.1 19 5.4 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Trypan_PARP PF05887.11 EDN07961.1 - 6 6.9 20.8 3.7 7.5 15.7 2.5 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) RNA_pol_Rpc34 PF05158.12 EDN07962.1 - 4.1e-108 361.7 0.0 4.9e-108 361.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.19 EDN07962.1 - 0.074 12.9 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 EDN07962.1 - 0.075 13.0 0.2 0.25 11.3 0.1 1.9 2 0 0 2 2 2 0 MarR family Rrf2 PF02082.20 EDN07962.1 - 0.086 13.2 0.1 0.23 11.8 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_36 PF13730.6 EDN07962.1 - 0.15 12.0 0.3 0.45 10.5 0.3 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_46 PF15977.5 EDN07962.1 - 0.18 11.8 0.8 0.45 10.6 0.2 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA binding ING PF12998.7 EDN07963.1 - 8.2e-23 80.9 4.7 1.4e-22 80.2 4.7 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDN07963.1 - 3.8e-05 23.5 9.9 6.8e-05 22.7 9.9 1.4 1 0 0 1 1 1 1 PHD-finger zf-C4pol PF14260.6 EDN07963.1 - 3.9 8.0 8.3 0.38 11.2 0.7 2.9 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta Hist_deacetyl PF00850.19 EDN07964.1 - 9.7e-80 268.3 0.0 1.4e-79 267.7 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Optomotor-blind PF11078.8 EDN07964.1 - 0.29 11.7 2.8 24 5.6 0.3 2.9 3 0 0 3 3 3 0 Optomotor-blind protein N-terminal region HTH_Tnp_1 PF01527.20 EDN07965.1 - 0.079 13.3 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Transposase DUF4771 PF15995.5 EDN07965.1 - 0.088 13.1 0.0 0.099 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) Oxysterol_BP PF01237.18 EDN07966.1 - 8.6e-72 242.0 0.1 1.4e-56 192.0 0.0 3.2 1 1 2 3 3 3 3 Oxysterol-binding protein DUF3605 PF12239.8 EDN07967.1 - 2.8e-43 147.9 1.5 8.6e-42 143.1 1.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) Isochorismatase PF00857.20 EDN07968.1 - 6e-19 68.9 0.3 3.2e-18 66.5 0.3 1.9 1 1 0 1 1 1 1 Isochorismatase family Acyl-CoA_dh_1 PF00441.24 EDN07969.1 - 2.2e-17 63.6 0.3 7.9e-17 61.8 0.3 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 EDN07969.1 - 2.2e-11 43.9 0.0 4.6e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 EDN07969.1 - 4.3e-11 42.9 0.0 8.7e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EDN07969.1 - 0.0054 17.0 0.0 0.017 15.4 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain gag-asp_proteas PF13975.6 EDN07970.1 - 0.0084 16.6 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Rabaptin PF03528.15 EDN07970.1 - 0.26 10.0 0.0 0.36 9.5 0.0 1.1 1 0 0 1 1 1 0 Rabaptin p450 PF00067.22 EDN07971.1 - 8.1e-69 232.5 0.0 9.8e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ssu72 PF04722.13 EDN07972.1 - 1.1e-80 269.7 0.0 1.3e-80 269.5 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein SNF2_N PF00176.23 EDN07973.1 - 4.9e-51 173.5 0.0 7.7e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EDN07973.1 - 7.9e-27 93.2 0.3 2.4e-26 91.6 0.3 1.9 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EDN07973.1 - 1.6e-18 67.1 0.0 3.2e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN07973.1 - 1.8e-06 28.1 0.0 6.2e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDN07973.1 - 2e-06 27.2 0.1 3.7e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase RNase_PH PF01138.21 EDN07974.1 - 8.9e-31 107.1 0.1 1.3e-30 106.6 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Pro_isomerase PF00160.21 EDN07975.1 - 9.2e-43 146.2 0.7 1.9e-42 145.2 0.7 1.5 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Dicer_N PF17895.1 EDN07975.1 - 0.17 11.8 0.8 0.3 10.9 0.8 1.4 1 0 0 1 1 1 0 Giardia Dicer N-terminal domain DUF1840 PF08895.11 EDN07976.1 - 0.02 15.2 0.0 0.04 14.2 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) GIT1_C PF12205.8 EDN07976.1 - 0.036 14.2 0.1 0.52 10.4 0.1 2.1 1 1 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term GIT_SHD PF08518.11 EDN07977.1 - 2.6e-19 68.5 5.4 6.5e-11 41.7 0.6 2.4 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT HMG-CoA_red PF00368.18 EDN07978.1 - 2.4e-62 211.1 1.0 2.8e-62 210.9 1.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Fungal_trans PF04082.18 EDN07980.1 - 3.9e-07 29.4 0.0 8e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN07980.1 - 2.7 8.2 5.3 0.26 11.4 0.5 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain SH3_1 PF00018.28 EDN07981.1 - 4.4e-11 42.2 0.0 9.8e-11 41.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN07981.1 - 8.3e-09 35.2 0.8 1.3e-08 34.6 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EDN07981.1 - 2.7e-07 30.2 0.0 6e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain ENTH PF01417.20 EDN07982.1 - 1.5e-46 157.5 0.4 1.5e-46 157.5 0.4 1.7 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.16 EDN07982.1 - 0.00019 20.6 0.1 0.00026 20.1 0.1 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 EDN07982.1 - 0.08 12.8 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 VHS domain Transp_cyt_pur PF02133.15 EDN07983.1 - 2.2e-38 132.2 32.2 2.9e-38 131.8 32.2 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Phage_Coat_Gp8 PF05371.12 EDN07983.1 - 0.34 10.7 2.4 41 4.0 0.0 3.3 3 0 0 3 3 3 0 Phage major coat protein, Gp8 DUF1129 PF06570.11 EDN07983.1 - 1.7 8.1 5.9 0.34 10.4 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) MWFE PF15879.5 EDN07983.1 - 2.3 8.5 4.2 1.6e+02 2.5 0.0 3.8 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase MWFE subunit RasGAP PF00616.19 EDN07984.1 - 6.6e-51 173.0 0.0 1.9e-50 171.5 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EDN07984.1 - 7.6e-51 171.9 6.0 2.4e-50 170.2 6.0 2.0 1 0 0 1 1 1 1 RasGAP C-terminus IQ PF00612.27 EDN07984.1 - 7.1e-13 47.1 35.6 0.35 10.8 0.2 14.0 15 0 0 15 15 15 6 IQ calmodulin-binding motif CH PF00307.31 EDN07984.1 - 1.7e-12 47.5 0.0 5.2e-12 45.9 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain IZUMO PF15005.6 EDN07984.1 - 1.7 9.2 5.8 0.36 11.3 0.2 2.9 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated IMPDH PF00478.25 EDN07985.1 - 5.8e-83 278.8 0.5 8.3e-46 156.6 0.0 2.0 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EDN07985.1 - 4.5e-08 33.4 0.1 4.2e-05 23.9 0.0 2.5 2 0 0 2 2 2 2 CBS domain GATase PF00117.28 EDN07986.1 - 3.6e-15 56.2 0.0 4.9e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EDN07986.1 - 0.00035 20.2 0.0 0.00078 19.1 0.0 1.4 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EDN07986.1 - 0.26 11.0 0.8 3.1 7.5 0.8 2.4 1 1 0 1 1 1 0 Peptidase C26 NUDIX PF00293.28 EDN07987.1 - 2.7e-07 30.7 0.0 1.1e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 NUDIX domain Ribosomal_S21e PF01249.18 EDN07988.1 - 6.6e-43 144.7 0.1 7.4e-43 144.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e tRNA-synt_2d PF01409.20 EDN07989.1 - 1.6e-87 293.0 0.0 2.1e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EDN07989.1 - 3.9e-15 55.9 0.4 1.1e-14 54.5 0.4 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EDN07989.1 - 7.7e-06 25.5 0.0 0.0026 17.2 0.0 2.4 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 EDN07989.1 - 2.9e-05 23.9 1.4 0.00011 22.1 1.4 2.1 1 1 0 1 1 1 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 EDN07989.1 - 0.00011 21.4 0.2 0.0032 16.6 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) SpoIIIAH PF12685.7 EDN07991.1 - 2.5 7.9 6.3 2 8.2 0.3 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein HAMP PF00672.25 EDN07992.1 - 3.8e-39 132.9 15.2 1.5e-08 34.9 0.2 7.8 6 2 1 7 7 7 5 HAMP domain HATPase_c PF02518.26 EDN07992.1 - 4.5e-32 110.9 0.1 1.9e-31 108.9 0.1 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDN07992.1 - 2.7e-25 88.7 0.8 1.1e-24 86.8 0.4 2.3 2 0 0 2 2 1 1 Response regulator receiver domain HisKA PF00512.25 EDN07992.1 - 7.3e-17 61.2 4.1 2.2e-16 59.7 0.1 3.9 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain APG17 PF04108.12 EDN07992.1 - 2.3e-10 40.2 4.9 0.091 11.9 3.8 5.6 1 1 3 4 4 4 3 Autophagy protein Apg17 Syntaxin_2 PF14523.6 EDN07992.1 - 6.9e-05 23.2 15.3 7.8 6.9 0.0 6.9 3 2 2 6 6 6 0 Syntaxin-like protein DUF4279 PF14106.6 EDN07992.1 - 0.00012 22.3 0.0 13 6.1 0.0 5.3 5 1 0 5 5 5 0 Domain of unknown function (DUF4279) Fib_alpha PF08702.10 EDN07992.1 - 0.0012 19.0 28.4 1.4 9.1 0.1 7.2 6 1 1 7 7 7 2 Fibrinogen alpha/beta chain family DUF3829 PF12889.7 EDN07992.1 - 0.0032 17.0 11.8 0.1 12.1 0.1 4.8 4 2 1 5 5 5 2 Protein of unknown function (DUF3829) HATPase_c_3 PF13589.6 EDN07992.1 - 0.013 15.3 0.0 0.042 13.7 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GLE1 PF07817.13 EDN07992.1 - 0.022 14.0 6.2 13 4.9 0.1 4.3 2 1 2 4 4 4 0 GLE1-like protein Gp-FAR-1 PF05823.12 EDN07992.1 - 0.03 14.7 3.9 26 5.1 0.1 4.9 1 1 4 6 6 6 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SpoIIID PF12116.8 EDN07992.1 - 0.037 14.1 2.6 24 5.1 0.0 4.6 4 0 0 4 4 3 0 Stage III sporulation protein D NOD PF06816.13 EDN07992.1 - 0.044 13.4 0.0 5.9 6.6 0.0 2.7 2 0 0 2 2 2 0 NOTCH protein DUF4795 PF16043.5 EDN07992.1 - 0.047 13.3 23.0 0.045 13.4 1.9 4.8 1 1 2 4 4 4 0 Domain of unknown function (DUF4795) IcmF_C PF06744.12 EDN07992.1 - 0.049 13.2 0.0 0.18 11.4 0.0 1.9 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal DDE_Tnp_1_3 PF13612.6 EDN07992.1 - 0.056 13.5 5.6 4.6 7.2 0.3 4.0 3 0 0 3 3 3 0 Transposase DDE domain DUF948 PF06103.11 EDN07992.1 - 0.12 12.6 53.9 2.2 8.6 0.1 9.7 4 1 2 6 6 5 0 Bacterial protein of unknown function (DUF948) CMD PF02627.20 EDN07992.1 - 0.16 12.0 1.2 13 5.9 0.0 4.0 4 0 0 4 4 4 0 Carboxymuconolactone decarboxylase family DUF5593 PF18007.1 EDN07992.1 - 0.36 11.6 4.4 32 5.3 0.3 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5593) AAA_13 PF13166.6 EDN07992.1 - 1.3 7.5 25.9 0.16 10.6 1.9 3.6 2 1 2 4 4 4 0 AAA domain POTRA_TamA_1 PF17243.2 EDN07992.1 - 4 7.6 7.2 3.7 7.7 1.1 3.9 3 0 0 3 3 3 0 POTRA domain TamA domain 1 BORCS6 PF10157.9 EDN07992.1 - 5.2 7.3 11.1 27 4.9 0.0 5.3 3 2 2 5 5 4 0 BLOC-1-related complex sub-unit 6 Noelin-1 PF12308.8 EDN07992.1 - 7.9 6.5 9.7 0.35 10.9 0.4 3.7 4 0 0 4 4 3 0 Neurogenesis glycoprotein Tristanin_u2 PF16638.5 EDN07993.1 - 5.5 7.8 8.1 13 6.6 8.1 1.6 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers MFS_1 PF07690.16 EDN07994.1 - 1e-32 113.5 69.2 5.6e-23 81.4 41.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN07994.1 - 4.3e-10 39.0 35.0 2.6e-07 29.9 16.9 2.5 1 1 1 2 2 2 2 Sugar (and other) transporter DUF5032 PF16435.5 EDN07995.1 - 0.26 10.7 0.2 0.4 10.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5032) MFS_1 PF07690.16 EDN07996.1 - 6.1e-30 104.3 35.2 9.5e-19 67.5 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN07996.1 - 5.3e-17 61.8 18.0 1.9e-16 60.0 17.7 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EDN07996.1 - 0.0063 15.4 1.3 0.0063 15.4 1.3 1.8 2 1 0 2 2 2 1 MFS_1 like family Pkinase PF00069.25 EDN07997.1 - 1.1e-68 231.5 0.0 7e-68 228.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN07997.1 - 7.7e-33 113.9 0.1 3.8e-31 108.3 0.1 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN07997.1 - 0.0049 16.2 3.5 0.63 9.3 0.2 3.0 3 1 0 3 3 3 2 Kinase-like RIO1 PF01163.22 EDN07997.1 - 0.0088 15.7 0.9 0.017 14.7 0.9 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EDN07997.1 - 0.06 12.1 0.7 0.15 10.8 0.0 2.0 3 0 0 3 3 3 0 Fungal protein kinase Peptidase_S10 PF00450.22 EDN07998.1 - 7.9e-61 206.7 0.0 9.3e-61 206.5 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Fungal_trans PF04082.18 EDN08000.1 - 3.9e-08 32.6 0.3 6.5e-08 31.9 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN08000.1 - 1.8e-06 28.0 8.7 3.6e-06 27.0 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4407 PF14362.6 EDN08000.1 - 5.1 6.4 4.8 8.4 5.7 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fungal_trans PF04082.18 EDN08003.1 - 4e-14 52.3 0.1 1.4e-13 50.5 0.1 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN08003.1 - 2.7e-06 27.4 6.6 5.7e-06 26.3 6.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta_elim_lyase PF01212.21 EDN08004.1 - 3.1e-57 194.1 0.0 3.9e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase NIF PF03031.18 EDN08005.1 - 1.5e-40 138.5 0.1 2.1e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase JAB PF01398.21 EDN08006.1 - 1.2e-16 60.7 0.0 2.6e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EDN08006.1 - 0.05 13.4 0.0 0.16 11.8 0.0 1.9 1 1 0 1 1 1 0 Prokaryotic homologs of the JAB domain Hist_deacetyl PF00850.19 EDN08007.1 - 1.2e-47 162.9 0.1 1.4e-47 162.7 0.1 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Ribosomal_L14 PF00238.19 EDN08009.1 - 1.4e-33 115.6 0.1 1.6e-33 115.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e PH PF00169.29 EDN08011.1 - 1.6e-10 41.4 0.0 1e-09 38.8 0.0 2.3 1 1 0 1 1 1 1 PH domain SH3_1 PF00018.28 EDN08011.1 - 6e-09 35.4 0.0 1.2e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN08011.1 - 9e-09 35.1 0.1 1.7e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 EDN08011.1 - 2.3e-08 34.0 0.3 4.1e-08 33.2 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EDN08011.1 - 0.00025 20.6 0.1 0.0005 19.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EDN08011.1 - 0.0013 19.1 0.4 0.0037 17.7 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain SAM_1 PF00536.30 EDN08011.1 - 0.004 17.5 0.1 0.0085 16.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 EDN08011.1 - 0.037 14.3 0.1 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain zf-MIZ PF02891.20 EDN08013.1 - 3.4e-10 39.5 0.1 9.2e-10 38.1 0.1 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EDN08013.1 - 0.0079 16.0 0.6 0.038 13.8 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit DUF5102 PF17104.5 EDN08014.1 - 7e-109 364.3 0.1 1e-108 363.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) Clathrin_bdg PF15045.6 EDN08014.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.5 1 0 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking Nsp1_C PF05064.13 EDN08015.1 - 1.7e-41 140.7 2.9 1.7e-41 140.7 2.9 1.7 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EDN08015.1 - 1.9e-05 25.4 54.9 0.0004 21.2 24.3 5.4 2 1 3 5 5 5 3 Nucleoporin FG repeat region DUF4200 PF13863.6 EDN08015.1 - 0.017 15.5 10.6 0.029 14.8 3.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ParB PF08775.10 EDN08015.1 - 0.018 15.6 0.8 0.049 14.1 0.8 1.6 1 0 0 1 1 1 0 ParB family APG17 PF04108.12 EDN08015.1 - 0.021 14.0 4.6 0.015 14.5 2.6 1.5 1 1 0 1 1 1 0 Autophagy protein Apg17 ERM PF00769.19 EDN08015.1 - 0.029 14.2 9.7 0.044 13.6 9.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF2935 PF11155.8 EDN08015.1 - 0.036 14.4 1.8 3.4 8.0 1.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) HIP1_clath_bdg PF16515.5 EDN08015.1 - 0.073 13.7 13.3 0.72 10.5 1.7 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_13 PF13166.6 EDN08015.1 - 0.092 11.4 6.3 0.14 10.8 6.3 1.3 1 0 0 1 1 1 0 AAA domain FliT PF05400.13 EDN08015.1 - 0.11 13.4 2.4 0.3 11.9 2.4 1.8 1 0 0 1 1 1 0 Flagellar protein FliT Baculo_PEP_C PF04513.12 EDN08015.1 - 0.14 12.2 4.1 0.26 11.3 3.5 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5063 PF16702.5 EDN08015.1 - 0.17 12.3 1.3 0.26 11.7 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) DUF1664 PF07889.12 EDN08015.1 - 0.5 10.4 7.5 0.56 10.3 1.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) IFT57 PF10498.9 EDN08015.1 - 0.54 9.2 10.9 0.097 11.6 3.3 2.0 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 Laminin_II PF06009.12 EDN08015.1 - 0.56 10.2 10.5 1.6 8.8 4.3 2.5 1 1 2 3 3 3 0 Laminin Domain II DUF4407 PF14362.6 EDN08015.1 - 1.4 8.2 8.7 2.5 7.3 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CK2S PF15011.6 EDN08015.1 - 1.5 8.7 8.7 60 3.5 8.5 2.4 1 1 0 1 1 1 0 Casein Kinase 2 substrate FlaC_arch PF05377.11 EDN08015.1 - 1.5 9.2 7.3 2.7 8.5 0.1 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) GAT PF03127.14 EDN08015.1 - 2.4 8.5 5.9 1.8 8.9 0.6 2.7 1 1 1 2 2 2 0 GAT domain CENP-Q PF13094.6 EDN08015.1 - 2.6 8.2 12.0 4.7 7.4 12.0 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF948 PF06103.11 EDN08015.1 - 2.6 8.4 4.3 81 3.6 4.0 2.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 EDN08015.1 - 3.9 6.3 13.3 1.4 7.8 4.3 2.2 1 1 0 2 2 2 0 Spc7 kinetochore protein Spectrin PF00435.21 EDN08015.1 - 4.3 7.9 10.0 1.1 9.8 4.1 2.6 1 1 1 2 2 2 0 Spectrin repeat DUF724 PF05266.14 EDN08015.1 - 6.9 6.4 7.4 1 9.1 1.7 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF724) BRE1 PF08647.11 EDN08015.1 - 7.8 6.6 11.8 6.1 7.0 3.1 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.14 EDN08015.1 - 8.1 6.8 14.2 5.8 7.3 0.4 2.3 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) IATP PF04568.12 EDN08016.1 - 1.1e-35 122.0 1.6 1.2e-35 121.9 1.6 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP BLOC1_2 PF10046.9 EDN08016.1 - 0.011 16.0 1.3 0.014 15.7 1.3 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PKHD_C PF18331.1 EDN08016.1 - 0.027 14.5 0.2 0.06 13.4 0.2 1.6 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain Fib_alpha PF08702.10 EDN08016.1 - 0.038 14.2 0.3 0.047 13.9 0.3 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family 14-3-3 PF00244.20 EDN08017.1 - 9.4e-106 352.3 7.9 1.1e-105 352.1 7.9 1.0 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 EDN08017.1 - 0.24 9.8 3.9 0.39 9.1 3.9 1.3 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 TPR_19 PF14559.6 EDN08017.1 - 1.2 9.7 4.9 0.75 10.3 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2205 PF10224.9 EDN08018.1 - 1.2e-35 121.3 2.0 2.3e-35 120.4 2.0 1.4 1 0 0 1 1 1 1 Short coiled-coil protein PI3K_P85_iSH2 PF16454.5 EDN08018.1 - 0.0029 17.2 2.0 0.0044 16.6 2.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3450 PF11932.8 EDN08018.1 - 0.0051 16.2 2.6 0.0068 15.7 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Tektin PF03148.14 EDN08018.1 - 0.0057 15.5 2.3 0.0089 14.8 2.3 1.2 1 0 0 1 1 1 1 Tektin family CENP-F_leu_zip PF10473.9 EDN08018.1 - 0.0059 16.6 2.1 0.011 15.7 2.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.18 EDN08018.1 - 0.0069 16.6 5.6 0.1 12.8 0.3 2.3 1 1 1 2 2 2 1 Homeobox associated leucine zipper YabA PF06156.13 EDN08018.1 - 0.008 16.8 0.5 0.013 16.1 0.5 1.3 1 0 0 1 1 1 1 Initiation control protein YabA Fmp27_WPPW PF10359.9 EDN08018.1 - 0.011 14.6 0.7 0.017 14.0 0.7 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Prefoldin PF02996.17 EDN08018.1 - 0.012 15.5 3.2 0.044 13.7 3.2 1.7 1 1 1 2 2 2 0 Prefoldin subunit DUF4201 PF13870.6 EDN08018.1 - 0.015 15.1 1.4 0.02 14.6 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) CASP_C PF08172.12 EDN08018.1 - 0.015 14.7 1.1 0.015 14.7 1.1 1.6 2 0 0 2 2 2 0 CASP C terminal LCD1 PF09798.9 EDN08018.1 - 0.022 13.3 1.5 0.029 12.9 1.5 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Spectrin PF00435.21 EDN08018.1 - 0.023 15.2 1.1 0.038 14.5 1.1 1.3 1 0 0 1 1 1 0 Spectrin repeat DUF5320 PF17253.2 EDN08018.1 - 0.026 15.6 0.7 0.12 13.4 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5320) FlxA PF14282.6 EDN08018.1 - 0.042 13.8 1.2 0.042 13.8 1.2 1.9 2 0 0 2 2 2 0 FlxA-like protein MitMem_reg PF13012.6 EDN08018.1 - 0.054 13.9 0.6 0.14 12.5 0.6 1.7 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function CCDC106 PF15794.5 EDN08018.1 - 0.058 13.1 4.4 0.18 11.5 0.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DivIC PF04977.15 EDN08018.1 - 0.068 12.9 2.1 0.11 12.3 2.1 1.4 1 0 0 1 1 1 0 Septum formation initiator Baculo_PEP_C PF04513.12 EDN08018.1 - 0.11 12.5 0.7 0.17 11.9 0.7 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3958 PF13125.6 EDN08018.1 - 0.17 12.1 3.2 1.3 9.2 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) bZIP_1 PF00170.21 EDN08018.1 - 0.18 11.9 4.2 3.8 7.7 5.3 2.1 1 1 1 2 2 2 0 bZIP transcription factor JIP_LZII PF16471.5 EDN08018.1 - 0.19 11.9 3.1 0.53 10.5 3.1 1.8 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II XhlA PF10779.9 EDN08018.1 - 0.26 11.5 2.3 0.53 10.5 0.5 2.0 1 1 1 2 2 2 0 Haemolysin XhlA ATG16 PF08614.11 EDN08018.1 - 0.36 11.0 8.8 0.48 10.6 8.8 1.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Glyco_hydro_76 PF03663.14 EDN08020.1 - 2.7e-16 60.1 3.7 4.6e-16 59.3 3.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 76 RRM_1 PF00076.22 EDN08021.1 - 2.7e-07 30.3 0.3 1.5e-06 27.9 0.3 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDN08021.1 - 0.035 14.2 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif Nup35_RRM_2 PF14605.6 EDN08021.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Cutinase PF01083.22 EDN08022.1 - 4.3e-40 137.6 0.0 7.6e-40 136.7 0.0 1.4 2 0 0 2 2 2 1 Cutinase PE-PPE PF08237.11 EDN08022.1 - 0.00015 21.4 0.0 0.00022 20.9 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain Lipase_3 PF01764.25 EDN08022.1 - 0.065 13.1 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) VirJ PF06057.11 EDN08022.1 - 0.092 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.16 EDN08022.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF5629 PF18629.1 EDN08023.1 - 0.029 14.9 5.9 0.91 10.1 0.0 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5629) PRKG1_interact PF15898.5 EDN08023.1 - 0.11 13.4 1.4 0.21 12.5 1.4 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Pes-10 PF07149.11 EDN08023.1 - 0.23 10.5 1.7 0.32 10.0 1.7 1.1 1 0 0 1 1 1 0 Pes-10 Alpha-amylase PF00128.24 EDN08024.1 - 9.3e-48 163.5 0.2 1.6e-47 162.8 0.2 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EDN08024.1 - 2e-23 82.5 0.0 3.9e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Bax1-I PF01027.20 EDN08025.1 - 6.3e-33 114.4 9.9 9.4e-33 113.8 9.9 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CGI-121 PF08617.10 EDN08026.1 - 1.6e-24 86.8 0.0 6.7e-18 65.3 0.0 2.0 1 1 1 2 2 2 2 Kinase binding protein CGI-121 Slx4 PF09494.10 EDN08027.1 - 3.9e-27 94.0 0.0 7.3e-27 93.1 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease Zn_clus PF00172.18 EDN08028.1 - 0.001 19.1 12.4 0.0019 18.3 12.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FlaC_arch PF05377.11 EDN08028.1 - 0.4 11.1 2.1 1.3 9.4 0.1 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) K_channel_TID PF07941.11 EDN08028.1 - 1.2 9.7 13.1 2.7 8.5 8.8 2.4 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain DUF2381 PF09544.10 EDN08028.1 - 7.2 6.0 8.6 0.48 9.9 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) cNMPbd_u2 PF16643.5 EDN08029.1 - 3.8e-38 131.4 1.6 3.8e-38 131.4 1.6 1.7 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EDN08029.1 - 5.7e-13 48.8 0.5 1.6e-12 47.3 0.5 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain LRR_6 PF13516.6 EDN08029.1 - 1.2e-10 40.6 3.6 1.6 9.0 0.1 6.4 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.7 EDN08029.1 - 3.2e-07 30.6 0.7 0.0078 16.6 0.2 4.1 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDN08029.1 - 0.0023 18.3 6.2 8.4 7.4 0.6 6.1 7 0 0 7 7 7 1 Leucine Rich Repeat SAM_Ste50p PF09235.10 EDN08029.1 - 0.057 13.7 1.4 4 7.7 0.2 3.3 2 1 0 2 2 2 0 Ste50p, sterile alpha motif Tim17 PF02466.19 EDN08031.1 - 5.4e-05 23.5 4.2 7.6e-05 23.1 3.8 1.4 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Kinesin PF00225.23 EDN08033.1 - 1.5e-117 392.2 0.0 2.4e-117 391.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDN08033.1 - 1.6e-26 93.0 0.9 2.7e-26 92.3 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding AAA_33 PF13671.6 EDN08033.1 - 0.0086 16.2 0.0 0.045 13.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDN08033.1 - 0.074 13.0 0.7 8.8 6.2 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea HR1 PF02185.16 EDN08033.1 - 0.079 13.1 0.9 0.32 11.1 0.1 2.5 2 0 0 2 2 2 0 Hr1 repeat AAA_16 PF13191.6 EDN08033.1 - 0.88 9.9 3.4 2.1 8.7 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain PMSR PF01625.21 EDN08034.1 - 2e-60 203.4 0.1 2.5e-60 203.1 0.1 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pro_dh PF01619.18 EDN08035.1 - 2.6e-70 237.3 0.8 3.2e-70 237.0 0.8 1.1 1 0 0 1 1 1 1 Proline dehydrogenase B1 PF02246.15 EDN08035.1 - 0.026 14.6 0.8 0.058 13.5 0.5 1.7 2 0 0 2 2 2 0 Protein L b1 domain Glyco_hydro_16 PF00722.21 EDN08037.1 - 4.9e-46 156.4 2.5 6.7e-46 156.0 2.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 EDN08037.1 - 0.018 15.5 14.3 0.035 14.6 14.3 1.4 1 0 0 1 1 1 0 Chitin recognition protein Alk_phosphatase PF00245.20 EDN08039.1 - 9.7e-97 324.5 0.1 1.1e-96 324.3 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EDN08039.1 - 0.0066 15.8 0.1 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF498 PF04430.14 EDN08040.1 - 1.2e-28 99.3 0.0 1.8e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) ABC_tran PF00005.27 EDN08041.1 - 6.3e-32 111.0 0.0 1.9e-31 109.4 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EDN08041.1 - 3.2e-22 79.5 6.0 7.3e-13 48.8 0.2 2.2 1 1 1 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EDN08041.1 - 1.5e-07 31.1 0.0 4.2e-06 26.3 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EDN08041.1 - 0.0086 16.3 0.6 0.35 11.1 0.6 2.8 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 EDN08041.1 - 0.0096 16.2 0.2 0.059 13.6 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN08041.1 - 0.02 15.3 3.1 0.18 12.2 3.1 2.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EDN08041.1 - 0.031 14.0 0.1 0.1 12.4 0.1 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN08041.1 - 0.074 12.9 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_10 PF12846.7 EDN08041.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_5 PF07728.14 EDN08041.1 - 0.12 12.3 0.1 1.4 8.9 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) WD40 PF00400.32 EDN08044.1 - 6.9e-14 52.0 11.2 2.2e-05 25.1 0.3 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN08044.1 - 6.8e-06 26.3 0.8 9.3 6.6 0.0 5.0 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN08044.1 - 0.0013 18.7 0.0 0.27 11.1 0.0 3.1 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A CAP_N PF01213.19 EDN08044.1 - 0.22 11.0 7.0 0.76 9.2 7.0 1.9 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Rhodanese_C PF12368.8 EDN08045.1 - 0.96 9.9 8.9 0.15 12.4 3.5 2.1 2 0 0 2 2 2 0 Rhodanase C-terminal Meiotic_rec114 PF03525.14 EDN08046.1 - 0.014 14.4 0.5 0.014 14.4 0.5 2.1 2 0 0 2 2 2 0 Meiotic recombination protein rec114 XLF PF09302.11 EDN08047.1 - 5e-21 75.7 0.1 5.4e-21 75.6 0.1 1.0 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component PAXX PF15384.6 EDN08047.1 - 0.11 12.1 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Cactin_mid PF10312.9 EDN08048.1 - 4e-65 219.3 1.3 6.2e-65 218.6 1.3 1.3 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EDN08048.1 - 1.2e-57 193.2 7.6 2.2e-57 192.4 7.6 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DUF2423 PF10338.9 EDN08048.1 - 0.16 12.3 2.3 0.49 10.7 2.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) Forkhead PF00250.18 EDN08049.1 - 2.9e-21 75.5 0.3 4.3e-21 75.0 0.3 1.3 1 0 0 1 1 1 1 Forkhead domain DUF5374 PF17344.2 EDN08050.1 - 0.02 14.8 0.6 0.041 13.8 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5374) Ribosomal_L34e PF01199.18 EDN08051.1 - 2.2e-43 146.4 1.9 3.1e-43 146.0 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e Vps36-NZF-N PF16988.5 EDN08051.1 - 0.038 13.4 0.8 0.054 12.9 0.0 1.7 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PDGF PF00341.17 EDN08051.1 - 0.054 13.8 0.2 0.12 12.7 0.2 1.6 1 0 0 1 1 1 0 PDGF/VEGF domain PROCN PF08083.11 EDN08052.1 - 3.4e-166 553.0 4.9 3.4e-166 553.0 4.9 2.5 2 1 1 3 3 3 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EDN08052.1 - 2.5e-127 423.2 2.0 4.6e-127 422.3 2.0 1.5 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EDN08052.1 - 1e-84 282.3 2.3 6.1e-58 195.3 0.3 3.0 2 0 0 2 2 2 2 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EDN08052.1 - 7.6e-81 269.4 2.1 1.8e-80 268.2 2.1 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EDN08052.1 - 2.1e-70 235.0 0.1 4.4e-70 234.0 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 EDN08052.1 - 1.9e-48 163.5 0.4 5.8e-48 161.9 0.1 2.1 2 0 0 2 2 2 1 PROCT (NUC072) domain RRM_4 PF10598.9 EDN08052.1 - 2.7e-48 162.2 0.3 7e-48 160.9 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 Hom_end_hint PF05203.16 EDN08052.1 - 5e-10 39.7 1.3 8.7e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 Hom_end-associated Hint Hom_end PF05204.14 EDN08052.1 - 0.00013 22.1 0.0 0.00052 20.2 0.0 2.1 1 0 0 1 1 1 1 Homing endonuclease Myb_DNA-binding PF00249.31 EDN08053.1 - 4.7e-13 49.1 0.1 3.3e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08053.1 - 2.1e-12 47.1 0.1 2.9e-07 30.6 0.0 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Mrr_cat PF04471.12 EDN08053.1 - 0.12 12.4 0.2 3.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Restriction endonuclease SANT_DAMP1_like PF16282.5 EDN08053.1 - 1.2 9.4 3.7 4.6 7.5 0.2 2.6 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 SelP_N PF04592.14 EDN08053.1 - 4.1 6.7 22.6 4.2 6.7 9.9 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Endostatin PF06482.11 EDN08053.1 - 5 6.5 15.8 1.5 8.2 8.6 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin COX5B PF01215.19 EDN08054.1 - 2.3e-54 182.5 0.0 3.1e-54 182.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-C4_Topoisom PF01396.19 EDN08054.1 - 0.074 12.8 0.5 0.42 10.4 0.0 2.0 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Myb_DNA-binding PF00249.31 EDN08055.1 - 6.8e-16 58.2 2.9 1.3e-07 31.7 0.4 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08055.1 - 9.7e-11 41.8 2.6 2.4e-05 24.5 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EDN08055.1 - 0.058 13.3 1.0 0.12 12.3 0.9 1.6 1 1 0 1 1 1 0 Myb DNA-binding like Retinal PF15449.6 EDN08055.1 - 0.06 11.1 9.1 0.071 10.9 9.1 1.1 1 0 0 1 1 1 0 Retinal protein Myb_DNA-bind_6 PF13921.6 EDN08056.1 - 2.1e-05 24.7 0.1 0.033 14.4 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN08056.1 - 4.6e-05 23.5 0.0 0.0014 18.8 0.2 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain HOK_GEF PF01848.16 EDN08057.1 - 0.1 12.1 0.0 1.6 8.2 0.0 2.6 3 0 0 3 3 3 0 Hok/gef family Lac_bphage_repr PF06543.12 EDN08060.1 - 0.019 15.0 2.6 0.041 13.8 2.6 1.5 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor DUF3435 PF11917.8 EDN08061.1 - 3.9e-83 279.7 0.5 5.3e-83 279.3 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) DnaA_N PF11638.8 EDN08061.1 - 0.1 12.3 0.2 2.4 8.0 0.0 2.7 3 0 0 3 3 3 0 DnaA N-terminal domain eRF1_1 PF03463.15 EDN08062.1 - 2.9e-50 169.6 0.1 4.3e-50 169.0 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EDN08062.1 - 1e-17 64.6 0.0 2e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EDN08062.1 - 3.5e-16 59.7 0.0 1.4e-15 57.8 0.0 1.9 1 1 0 1 1 1 1 eRF1 domain 2 LptE PF04390.12 EDN08062.1 - 0.017 15.8 0.0 0.044 14.5 0.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide-assembly Aldo_ket_red PF00248.21 EDN08063.1 - 1.9e-37 129.1 0.0 4.8e-30 104.8 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Ribosomal_S19e PF01090.19 EDN08065.1 - 2.1e-58 195.9 0.2 2.3e-58 195.8 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DSPc PF00782.20 EDN08066.1 - 8.5e-09 35.3 0.0 2.2e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Abhydrolase_6 PF12697.7 EDN08066.1 - 1.7e-06 28.8 0.0 3.5e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EDN08066.1 - 6.9e-05 22.8 0.0 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 Serine hydrolase PTPlike_phytase PF14566.6 EDN08066.1 - 0.00028 21.0 0.0 0.00048 20.3 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Abhydrolase_1 PF00561.20 EDN08066.1 - 0.0016 18.1 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN08066.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Y_phosphatase PF00102.27 EDN08066.1 - 0.051 13.1 0.0 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein-tyrosine phosphatase LCAT PF02450.15 EDN08066.1 - 0.1 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 EDN08066.1 - 0.2 11.1 0.0 0.37 10.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) ILVD_EDD PF00920.21 EDN08067.1 - 7.9e-185 615.4 2.5 9.7e-185 615.1 2.5 1.0 1 0 0 1 1 1 1 Dehydratase family MFS_1 PF07690.16 EDN08068.1 - 5.9e-29 101.1 22.5 7.2e-29 100.8 22.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Paramecium_SA PF01508.16 EDN08069.1 - 7.8 7.0 15.1 0.22 12.0 6.9 2.3 2 0 0 2 2 2 0 Paramecium surface antigen domain Pex2_Pex12 PF04757.14 EDN08070.1 - 1.2e-35 123.1 1.3 1.7e-35 122.7 1.3 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_UBOX PF13445.6 EDN08070.1 - 0.0012 18.8 1.3 0.0044 17.0 1.3 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EDN08070.1 - 0.0021 18.2 5.0 0.0021 18.2 5.0 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EDN08070.1 - 0.018 14.9 2.4 0.12 12.2 0.4 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN08070.1 - 0.037 13.9 1.2 0.094 12.6 1.2 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN08070.1 - 0.6 10.5 5.4 4.8 7.6 1.7 2.4 2 0 0 2 2 2 0 Ring finger domain Ferritin_2 PF13668.6 EDN08071.1 - 0.12 12.6 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Ferritin-like domain APH PF01636.23 EDN08072.1 - 4.6e-11 43.1 0.0 4.8e-10 39.8 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN08072.1 - 0.0043 16.4 0.0 0.0059 16.0 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EDN08072.1 - 0.016 14.8 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EDN08072.1 - 0.083 11.7 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Kdo PF06293.14 EDN08072.1 - 0.16 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mig-14 PF07395.11 EDN08072.1 - 0.23 10.8 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Mig-14 GBP PF02263.19 EDN08073.1 - 0.061 12.6 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain Cellulase PF00150.18 EDN08074.1 - 4.4e-20 72.3 0.2 4.4e-20 72.3 0.2 1.3 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 EDN08074.1 - 0.012 14.9 0.1 2.7 7.2 0.0 2.1 1 1 0 2 2 2 0 Beta-galactosidase DUF3922 PF13059.6 EDN08074.1 - 0.17 12.3 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) GPI-anchored PF10342.9 EDN08077.1 - 3.5e-24 85.4 1.4 3.6e-24 85.3 0.1 1.6 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CCDC-167 PF15188.6 EDN08078.1 - 0.032 14.6 1.3 0.032 14.6 1.3 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 USP8_interact PF08941.10 EDN08078.1 - 0.16 11.8 1.7 0.31 10.8 1.7 1.5 1 0 0 1 1 1 0 USP8 interacting Golgin_A5 PF09787.9 EDN08078.1 - 0.2 11.1 12.3 0.4 10.1 12.3 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF16 PF01519.16 EDN08078.1 - 2 8.9 6.9 3.9 8.0 5.7 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.7 EDN08078.1 - 2.3 8.4 13.9 5 7.3 9.1 2.4 1 1 1 2 2 2 0 Tropomyosin like CENP-F_leu_zip PF10473.9 EDN08078.1 - 4.1 7.4 15.1 2.4 8.2 6.7 2.3 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4404 PF14357.6 EDN08078.1 - 8.5 7.1 6.0 4.5 8.0 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) BST2 PF16716.5 EDN08078.1 - 9.8 6.8 7.7 35 5.1 0.6 3.0 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF5427 PF10310.9 EDN08079.1 - 5.4e-163 543.3 0.0 6.5e-163 543.0 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) CMD PF02627.20 EDN08080.1 - 3.9e-07 30.0 0.0 1.3e-06 28.4 0.1 1.8 1 1 1 2 2 2 1 Carboxymuconolactone decarboxylase family zf-Mss51 PF13824.6 EDN08082.1 - 0.0094 16.0 0.8 0.025 14.7 0.8 1.6 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 C1_1 PF00130.22 EDN08082.1 - 0.026 14.4 1.3 0.048 13.6 1.3 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_4 PF13894.6 EDN08082.1 - 0.068 14.0 4.7 0.29 12.1 0.2 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger DDE_1 PF03184.19 EDN08083.1 - 4.5e-30 104.6 0.0 2e-29 102.5 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN08083.1 - 0.0014 18.4 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease TFR_dimer PF04253.15 EDN08084.1 - 1.5e-32 112.3 0.2 2.5e-32 111.5 0.2 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDN08084.1 - 2.2e-21 76.4 0.1 4.5e-21 75.5 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EDN08084.1 - 1.3e-08 34.7 0.1 4e-08 33.2 0.1 1.8 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 EDN08084.1 - 0.035 13.6 0.3 0.068 12.6 0.0 1.5 2 0 0 2 2 2 0 Nicastrin MFS_1 PF07690.16 EDN08085.1 - 6.4e-35 120.7 39.0 2.9e-33 115.3 18.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN08085.1 - 9.2e-10 38.0 4.1 9.2e-10 38.0 4.1 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EDN08085.1 - 0.00044 18.8 0.7 0.00093 17.7 0.7 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ExoD PF06055.12 EDN08085.1 - 0.0048 16.3 0.5 0.0048 16.3 0.5 2.1 2 0 0 2 2 2 1 Exopolysaccharide synthesis, ExoD Ribosomal_S12 PF17487.2 EDN08085.1 - 4.5 8.1 13.1 0.61 10.9 7.3 2.4 2 0 0 2 2 2 0 Ribosomal protein S12 p450 PF00067.22 EDN08086.1 - 1.1e-54 185.9 0.0 4.1e-54 184.1 0.0 1.6 1 1 0 2 2 2 1 Cytochrome P450 Fungal_trans PF04082.18 EDN08087.1 - 4.6e-12 45.5 0.4 7.5e-12 44.8 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ATP-grasp_6 PF18419.1 EDN08087.1 - 0.1 12.3 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp-like domain DUF726 PF05277.12 EDN08088.1 - 7.6e-127 422.9 4.2 1.1e-126 422.5 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) UPF0565 PF10561.9 EDN08088.1 - 0.17 11.1 0.1 0.57 9.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 RTC4 PF14474.6 EDN08089.1 - 5.6e-33 113.7 0.0 1e-32 112.8 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Tmemb_14 PF03647.13 EDN08090.1 - 2.3e-22 79.5 4.8 3e-22 79.2 4.8 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C XK-related PF09815.9 EDN08090.1 - 0.073 12.1 0.0 0.077 12.0 0.0 1.2 1 0 0 1 1 1 0 XK-related protein DUF4131 PF13567.6 EDN08090.1 - 0.32 10.7 1.4 0.42 10.2 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Phage_r1t_holin PF16945.5 EDN08090.1 - 2.1 8.6 4.8 8.3 6.7 4.3 2.2 1 1 1 2 2 2 0 Putative lactococcus lactis phage r1t holin DAD PF02109.16 EDN08091.1 - 1.1e-45 154.3 0.2 1.9e-45 153.6 0.2 1.3 1 1 0 1 1 1 1 DAD family HA2 PF04408.23 EDN08092.1 - 6.5e-20 71.4 0.0 6.5e-20 71.4 0.0 3.3 4 0 0 4 4 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDN08092.1 - 2.2e-16 60.0 0.0 9.7e-16 57.9 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDN08092.1 - 1.2e-14 54.6 0.0 2.9e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN08092.1 - 1.8e-07 31.1 0.1 3.3e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDN08092.1 - 0.00023 21.5 0.1 0.00055 20.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN08092.1 - 0.00051 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDN08092.1 - 0.00096 18.5 0.0 0.0022 17.3 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EDN08092.1 - 0.0011 19.4 0.1 0.0023 18.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDN08092.1 - 0.004 16.3 0.0 0.0097 15.0 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 EDN08092.1 - 0.01 15.5 0.5 0.026 14.1 0.5 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EDN08092.1 - 0.011 15.8 0.2 0.062 13.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EDN08092.1 - 0.024 14.0 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 KaiC ResIII PF04851.15 EDN08092.1 - 0.026 14.5 0.0 9.3 6.2 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 EDN08092.1 - 0.032 14.4 0.5 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDN08092.1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Flavi_DEAD PF07652.14 EDN08092.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.16 EDN08092.1 - 0.093 12.2 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EDN08092.1 - 0.097 12.6 0.2 1 9.2 0.1 2.2 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 EDN08092.1 - 0.12 11.9 0.2 0.74 9.4 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EDN08092.1 - 0.13 12.6 0.0 0.43 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain CBFD_NFYB_HMF PF00808.23 EDN08093.1 - 2.4e-13 50.2 0.2 3.8e-12 46.3 0.2 2.1 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Fungal_trans PF04082.18 EDN08096.1 - 0.00014 21.0 0.3 0.0012 18.0 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain NDC10_II PF16787.5 EDN08097.1 - 1.1e-40 139.7 6.5 9.9e-20 70.8 0.0 2.5 1 1 1 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN08097.1 - 1.5e-11 44.4 2.1 2.2e-11 43.9 0.0 2.4 3 0 0 3 3 3 1 Transcriptional activator of glycolytic enzymes DUF4887 PF16228.5 EDN08097.1 - 0.02 15.1 1.5 0.02 15.1 1.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4887) PSII_Pbs27 PF13326.6 EDN08097.1 - 0.03 14.6 0.3 0.06 13.7 0.3 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 DRY_EERY PF09750.9 EDN08097.1 - 0.051 13.8 0.4 0.051 13.8 0.4 1.7 2 0 0 2 2 2 0 Alternative splicing regulator FUSC PF04632.12 EDN08097.1 - 0.057 11.9 0.4 0.098 11.2 0.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Dot_icm_IcmQ PF09475.10 EDN08097.1 - 0.13 11.8 2.7 0.37 10.3 1.3 2.2 2 0 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Toxin_10 PF05431.11 EDN08099.1 - 0.076 12.5 0.2 0.13 11.7 0.2 1.4 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 AAA PF00004.29 EDN08101.1 - 2.4e-12 47.4 0.0 5e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN08101.1 - 0.00033 21.1 0.0 0.0027 18.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDN08101.1 - 0.001 19.3 0.2 0.026 14.8 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_2 PF07724.14 EDN08101.1 - 0.01 16.0 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDN08101.1 - 0.034 14.1 0.0 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDN08101.1 - 0.17 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ank PF00023.30 EDN08102.1 - 8e-20 70.3 2.5 2.8e-07 30.7 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 EDN08102.1 - 3.7e-19 69.1 0.4 2e-10 41.1 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN08102.1 - 7e-19 67.9 0.1 7.8e-06 26.3 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN08102.1 - 1.9e-18 66.2 0.9 1.1e-09 38.4 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN08102.1 - 2.5e-17 61.2 0.5 6.1e-06 26.2 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat DDE_1 PF03184.19 EDN08103.1 - 1.7e-33 115.7 0.0 3.1e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN08103.1 - 1.1e-10 41.3 0.0 2.3e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN08103.1 - 2.2e-06 27.3 0.1 5.6e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN08103.1 - 1.8e-05 24.6 0.0 0.00059 19.6 0.0 2.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_28 PF13518.6 EDN08103.1 - 0.079 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3435 PF11917.8 EDN08104.1 - 1.2e-112 377.0 1.7 2.8e-111 372.4 0.9 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) Dzip-like_N PF13815.6 EDN08105.1 - 0.035 14.1 3.5 0.11 12.5 3.5 1.8 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal EMC3_TMCO1 PF01956.16 EDN08105.1 - 0.33 10.7 2.1 0.44 10.3 2.1 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Pkinase_fungal PF17667.1 EDN08106.1 - 3.6e-141 470.6 0.0 4.5e-141 470.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN08106.1 - 2.5e-07 30.3 0.0 4.6e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDN08106.1 - 0.0087 16.0 0.2 0.025 14.5 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EDN08106.1 - 0.0099 15.2 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Aminotran_1_2 PF00155.21 EDN08107.1 - 4.8e-16 58.9 0.0 6.3e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EDN08107.1 - 0.00011 21.1 0.0 0.00043 19.2 0.0 1.7 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 EDN08107.1 - 0.016 14.5 0.0 0.07 12.4 0.0 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pkinase PF00069.25 EDN08108.1 - 1.9e-54 184.8 0.0 2.5e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08108.1 - 1e-38 133.1 0.0 1.5e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN08108.1 - 8.9e-05 21.9 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDN08108.1 - 0.0018 17.1 0.0 0.0033 16.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDN08108.1 - 0.0032 17.4 0.0 0.0072 16.3 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN08108.1 - 0.016 14.5 0.3 0.037 13.4 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDN08108.1 - 0.057 13.0 0.1 2.6 7.6 0.0 2.2 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 EDN08108.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EDN08108.1 - 0.13 11.7 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EDN08108.1 - 0.15 10.9 0.1 5.1 5.9 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain SR-25 PF10500.9 EDN08109.1 - 3.3 7.3 17.5 0.17 11.5 11.6 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 EDN08110.1 - 2.5e-59 200.8 0.0 4e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08110.1 - 1.8e-26 93.0 0.1 3.7e-26 92.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN08110.1 - 6.7e-05 22.3 0.0 9.9e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDN08110.1 - 0.0066 15.8 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TetR_C_27 PF17935.1 EDN08110.1 - 0.085 12.9 0.0 0.72 9.9 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain APH PF01636.23 EDN08110.1 - 0.14 12.1 0.3 0.71 9.8 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family GHMP_kinases_C PF08544.13 EDN08111.1 - 0.76 10.2 3.0 1.4 9.3 0.7 2.2 1 1 2 3 3 3 0 GHMP kinases C terminal UQ_con PF00179.26 EDN08112.1 - 3.9e-21 75.2 7.8 8.8e-21 74.0 7.8 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Mucin PF01456.17 EDN08112.1 - 0.002 18.1 18.2 0.0028 17.7 18.2 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein RWD PF05773.22 EDN08112.1 - 0.0098 16.2 0.4 0.021 15.1 0.4 1.5 1 1 0 1 1 1 1 RWD domain SOG2 PF10428.9 EDN08112.1 - 0.077 12.2 5.2 0.075 12.2 5.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein ROS_MUCR PF05443.11 EDN08112.1 - 0.17 12.0 0.7 2 8.5 0.0 2.4 3 0 0 3 3 3 0 ROS/MUCR transcriptional regulator protein AF-4 PF05110.13 EDN08112.1 - 0.22 9.6 8.2 0.27 9.3 8.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SSP160 PF06933.11 EDN08112.1 - 0.29 9.3 11.5 0.32 9.1 11.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Med3 PF11593.8 EDN08112.1 - 0.34 10.1 7.9 0.37 9.9 7.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TALPID3 PF15324.6 EDN08112.1 - 0.48 8.0 8.2 0.6 7.7 8.2 1.1 1 0 0 1 1 1 0 Hedgehog signalling target Hamartin PF04388.12 EDN08112.1 - 0.75 8.4 5.8 0.74 8.4 5.8 1.1 1 0 0 1 1 1 0 Hamartin protein NAM-associated PF14303.6 EDN08112.1 - 4.6 7.9 6.2 7.2 7.3 6.2 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain MSA-2c PF12238.8 EDN08112.1 - 5.6 6.9 10.4 7.6 6.5 10.4 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF515 PF04415.12 EDN08112.1 - 9.1 4.5 7.5 13 4.0 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Complex1_49kDa PF00346.19 EDN08113.1 - 1.3e-125 418.0 0.0 1.7e-125 417.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EDN08113.1 - 0.012 14.5 0.0 0.021 13.8 0.0 1.4 1 1 0 1 1 1 0 Nickel-dependent hydrogenase RNA_pol_A_bac PF01000.26 EDN08114.1 - 3.7e-27 94.9 0.0 6.8e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDN08114.1 - 9.1e-19 66.7 0.0 1.3e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain ThiF PF00899.21 EDN08115.1 - 2.4e-61 207.2 0.0 3.5e-61 206.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EDN08115.1 - 7.9e-25 86.8 0.2 1.3e-24 86.1 0.2 1.4 1 0 0 1 1 1 1 E2 binding domain Ecm33 PF12454.8 EDN08115.1 - 0.033 14.3 2.0 0.068 13.3 2.0 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein UBA_e1_thiolCys PF10585.9 EDN08115.1 - 0.17 11.8 2.6 4.3 7.2 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site Telomere_reg-2 PF10193.9 EDN08116.1 - 4.8e-27 94.6 0.0 1.2e-26 93.3 0.0 1.7 1 0 0 1 1 1 1 Telomere length regulation protein Sec1 PF00995.23 EDN08117.1 - 1e-119 401.4 0.0 1.1e-119 401.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family UPF0014 PF03649.13 EDN08117.1 - 0.074 12.4 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) EcoR124_C PF12008.8 EDN08117.1 - 0.17 11.5 0.0 1.5 8.4 0.0 2.3 3 0 0 3 3 3 0 Type I restriction and modification enzyme - subunit R C terminal zf-met PF12874.7 EDN08119.1 - 7.2e-06 26.2 1.3 1.8e-05 25.0 1.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EDN08119.1 - 9.2e-06 25.8 5.7 2.2e-05 24.7 4.5 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN08119.1 - 2.6e-05 24.4 7.3 0.024 15.1 0.5 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDN08119.1 - 5.1e-05 23.2 2.4 0.00012 22.0 2.4 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDN08119.1 - 0.00074 19.7 1.8 0.00074 19.7 1.8 2.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDN08119.1 - 0.0013 19.4 3.2 0.0013 19.4 3.2 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger Actin_micro PF17003.5 EDN08119.1 - 0.17 11.1 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Putative actin-like family DUF1631 PF07793.11 EDN08119.1 - 0.95 7.8 5.6 1.1 7.6 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) SF3b1 PF08920.10 EDN08121.1 - 2.3e-33 115.2 11.2 2e-31 108.9 11.2 3.1 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT_EZ PF13513.6 EDN08121.1 - 5.7e-12 45.9 1.2 0.011 16.2 0.0 7.0 7 0 0 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 EDN08121.1 - 8.1e-11 42.2 7.6 0.2 12.1 0.1 8.0 5 3 3 9 9 9 3 HEAT repeats HEAT PF02985.22 EDN08121.1 - 1.2e-08 34.5 8.7 0.73 10.3 0.1 8.9 10 0 0 10 10 10 2 HEAT repeat Cnd1 PF12717.7 EDN08121.1 - 1.8e-06 28.1 0.2 3.7 7.6 0.0 5.7 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDN08121.1 - 9.9e-05 22.9 0.0 2.8 8.6 0.0 5.0 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 EDN08121.1 - 0.00016 21.4 0.4 1.1 8.8 0.0 4.2 4 0 0 4 4 4 2 NUC173 domain UNC45-central PF11701.8 EDN08121.1 - 0.00059 19.8 0.0 0.0018 18.2 0.0 1.8 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central DUF3385 PF11865.8 EDN08121.1 - 0.00082 19.3 0.8 0.066 13.1 0.1 4.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 EDN08121.1 - 0.0048 16.5 0.4 0.9 9.1 0.0 3.5 4 0 0 4 4 4 1 CLASP N terminal DRIM PF07539.12 EDN08121.1 - 0.061 11.6 0.0 8.7 4.5 0.0 3.5 1 1 1 2 2 2 0 Down-regulated in metastasis Methyltransf_11 PF08241.12 EDN08122.1 - 0.00061 20.4 0.0 0.0015 19.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN08122.1 - 0.044 14.5 0.0 0.12 13.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain SAP PF02037.27 EDN08123.1 - 2.2e-12 46.4 0.5 1.3e-11 43.9 0.1 2.2 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 EDN08123.1 - 1.8e-06 27.7 0.8 1.8e-06 27.7 0.8 1.9 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain SSrecog PF03531.14 EDN08125.1 - 2.1e-30 104.4 0.1 1.7e-29 101.5 0.0 2.6 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 EDN08125.1 - 1.7e-19 70.0 0.1 2.3e-18 66.4 0.1 2.5 2 0 0 2 2 2 1 Histone chaperone Rttp106-like POB3_N PF17292.2 EDN08125.1 - 7.8e-15 55.1 0.0 7.3e-14 52.0 0.0 2.4 1 1 1 2 2 2 1 POB3-like N-terminal PH domain PH_TFIIH PF08567.11 EDN08125.1 - 0.011 16.1 0.0 0.27 11.6 0.0 2.7 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain Glyco_hydro_76 PF03663.14 EDN08126.1 - 4.9e-36 125.0 0.4 4.9e-36 125.0 0.4 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 76 DUF3884 PF13024.6 EDN08126.1 - 0.061 12.9 0.6 0.14 11.7 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) Pro_CA PF00484.19 EDN08127.1 - 2.2e-49 167.8 0.0 4.2e-49 166.8 0.0 1.5 1 0 0 1 1 1 1 Carbonic anhydrase DUF3435 PF11917.8 EDN08127.1 - 1.3e-07 30.9 2.8 0.003 16.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) ClpB_D2-small PF10431.9 EDN08128.1 - 0.07 13.2 0.0 5.1 7.2 0.0 2.4 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Kdo PF06293.14 EDN08129.1 - 0.0012 18.2 0.3 0.0024 17.2 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN08129.1 - 0.013 15.1 0.1 0.039 13.5 0.0 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 EDN08129.1 - 0.02 14.5 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN08129.1 - 0.064 13.2 0.2 0.064 13.2 0.2 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family SurA_N_2 PF13623.6 EDN08129.1 - 0.24 11.3 0.4 0.58 10.0 0.4 1.6 1 0 0 1 1 1 0 SurA N-terminal domain SurA_N_3 PF13624.6 EDN08129.1 - 1.6 8.5 3.5 2.5 7.9 2.4 1.8 2 0 0 2 2 2 0 SurA N-terminal domain RVT_2 PF07727.14 EDN08130.1 - 7.5e-49 166.6 0.0 3.4e-48 164.4 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN08130.1 - 1.5e-12 47.7 0.0 5.1e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN08130.1 - 7.7e-08 32.1 0.0 2.4e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_3 PF13456.6 EDN08130.1 - 0.059 13.2 0.3 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase-like rve_3 PF13683.6 EDN08130.1 - 0.06 13.1 0.0 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain eIF3g PF12353.8 EDN08130.1 - 0.11 12.9 6.6 0.38 11.1 6.6 1.9 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Kei1 PF08552.11 EDN08130.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 zf-CCHC PF00098.23 EDN08130.1 - 0.34 11.1 5.3 0.73 10.0 5.3 1.6 1 0 0 1 1 1 0 Zinc knuckle NPR3 PF03666.13 EDN08130.1 - 2 7.1 10.1 3.2 6.4 9.3 1.6 1 1 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BCS1_N PF08740.11 EDN08131.1 - 1.3e-19 70.9 0.2 4.5e-19 69.1 0.1 1.7 1 1 1 2 2 2 1 BCS1 N terminal AAA PF00004.29 EDN08131.1 - 2.3e-19 70.1 0.0 1.3e-18 67.7 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN08131.1 - 8.3e-06 26.3 0.1 1.5e-05 25.5 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDN08131.1 - 0.023 15.3 0.0 0.55 10.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EDN08131.1 - 0.035 12.9 0.0 0.056 12.3 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 EDN08131.1 - 0.051 13.6 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EDN08131.1 - 0.058 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 KaiC RuvB_N PF05496.12 EDN08131.1 - 0.061 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EDN08131.1 - 0.067 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN08131.1 - 0.087 13.0 0.0 2 8.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN08131.1 - 0.091 12.5 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EDN08131.1 - 0.1 11.7 0.0 0.68 9.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF815) Rnf-Nqr PF02508.14 EDN08132.1 - 0.007 16.4 0.6 0.0083 16.1 0.6 1.2 1 0 0 1 1 1 1 Rnf-Nqr subunit, membrane protein 7TMR-DISM_7TM PF07695.11 EDN08132.1 - 0.0085 16.0 2.4 0.0089 15.9 2.4 1.1 1 0 0 1 1 1 1 7TM diverse intracellular signalling DUF5392 PF17370.2 EDN08132.1 - 0.19 11.8 0.5 0.29 11.2 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5392) Mur_ligase_M PF08245.12 EDN08134.1 - 3.1e-06 27.3 0.0 5.5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Pkinase_fungal PF17667.1 EDN08135.1 - 9.7e-114 380.3 0.0 1.4e-113 379.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase zf-C2H2 PF00096.26 EDN08136.1 - 0.0059 17.0 9.3 0.2 12.2 1.3 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type DUF2383 PF09537.10 EDN08136.1 - 0.048 14.0 0.1 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) Ribosomal_L37e PF01907.19 EDN08136.1 - 0.053 13.7 0.5 0.16 12.2 0.5 1.8 1 0 0 1 1 1 0 Ribosomal protein L37e zf-C2H2_4 PF13894.6 EDN08136.1 - 0.06 14.2 0.3 0.06 14.2 0.3 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger Ferritin-like PF12902.7 EDN08136.1 - 0.13 12.1 0.1 0.17 11.7 0.1 1.6 1 1 0 1 1 1 0 Ferritin-like MAR_sialic_bdg PF10564.9 EDN08136.1 - 4.5 7.4 7.4 18 5.5 2.6 2.5 1 1 1 2 2 2 0 Sialic-acid binding micronemal adhesive repeat RVT_1 PF00078.27 EDN08137.1 - 1.1e-38 133.0 0.0 1.5e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LD_cluster3 PF18180.1 EDN08137.1 - 0.13 11.9 0.0 17 5.0 0.0 2.3 2 0 0 2 2 2 0 SLOG cluster3 family DUF3723 PF12520.8 EDN08139.1 - 1.9e-157 525.1 0.1 2.3e-157 524.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) DUF3435 PF11917.8 EDN08140.1 - 4.7e-26 91.7 0.0 3.3e-25 88.9 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3435) Rax2 PF12768.7 EDN08142.1 - 1.1e-67 227.7 0.0 2.5e-67 226.5 0.0 1.7 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Kelch_4 PF13418.6 EDN08142.1 - 0.36 10.9 6.9 14 5.8 0.0 4.8 5 0 0 5 5 5 0 Galactose oxidase, central domain OGG_N PF07934.12 EDN08144.1 - 2.1e-38 131.1 0.0 4.1e-38 130.2 0.0 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EDN08144.1 - 3.4e-18 66.1 0.0 6.6e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein RRM_1 PF00076.22 EDN08145.1 - 1.6e-36 123.9 0.7 1.4e-14 53.6 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDN08145.1 - 5.6e-06 26.1 0.0 0.82 9.6 0.0 3.4 3 0 0 3 3 3 3 Occluded RNA-recognition motif DUF3435 PF11917.8 EDN08146.1 - 1.1e-16 60.8 0.1 1.3e-13 50.7 1.5 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) APH PF01636.23 EDN08148.1 - 2.9e-11 43.8 0.0 4.3e-10 39.9 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDN08148.1 - 0.00097 18.5 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase 7tm_2 PF00002.24 EDN08150.1 - 1.8e-05 24.2 11.4 2.2e-05 23.9 11.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EDN08150.1 - 0.00026 20.2 6.3 0.00034 19.8 6.3 1.2 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor DUF1772 PF08592.11 EDN08150.1 - 0.12 12.7 4.7 4.2 7.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF4328 PF14219.6 EDN08150.1 - 4.6 6.8 8.3 2.1 7.9 0.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4328) Chromate_transp PF02417.15 EDN08151.1 - 5.7e-59 198.8 32.2 1.3e-32 113.1 17.3 2.3 2 0 0 2 2 2 2 Chromate transporter Ribosomal_S13_N PF08069.12 EDN08152.1 - 1.2e-30 105.4 0.1 1.9e-30 104.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EDN08152.1 - 9.4e-16 57.8 0.4 1.3e-15 57.3 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 EDN08152.1 - 0.029 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain HOIP-UBA PF16678.5 EDN08152.1 - 0.068 13.2 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 HOIP UBA domain pair VRR_NUC PF08774.11 EDN08153.1 - 8e-26 90.2 0.0 1.8e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 VRR-NUC domain SH3_1 PF00018.28 EDN08153.1 - 0.037 13.7 0.2 0.089 12.4 0.2 1.7 1 0 0 1 1 1 0 SH3 domain RRM_1 PF00076.22 EDN08154.1 - 1e-20 73.3 0.0 1.7e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN08154.1 - 0.0004 20.0 0.0 0.00059 19.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-HC5HC2H_2 PF13832.6 EDN08155.1 - 5.5e-32 110.2 5.3 5.5e-32 110.2 5.3 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 EDN08155.1 - 1.2e-31 110.2 0.0 3.1e-31 108.9 0.0 1.8 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 EDN08155.1 - 2.3e-27 95.1 2.6 2.3e-27 95.1 2.6 2.7 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.6 EDN08155.1 - 5.3e-14 51.5 2.9 5.3e-14 51.5 2.9 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EDN08155.1 - 9.5e-09 35.0 9.6 9.5e-09 35.0 9.6 2.6 2 0 0 2 2 2 2 PHD-finger Myb_DNA-bind_6 PF13921.6 EDN08157.1 - 1.1e-07 32.0 0.5 2.8e-07 30.7 0.2 1.9 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN08157.1 - 8.7e-05 22.6 0.2 0.00024 21.3 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Peptidase_M22 PF00814.25 EDN08158.1 - 9.4e-48 163.2 0.0 8.1e-42 143.8 0.0 3.7 2 1 0 2 2 2 2 Glycoprotease family YycC PF14174.6 EDN08158.1 - 0.0071 16.1 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 YycC-like protein IMUP PF15761.5 EDN08158.1 - 1.5 9.6 8.4 3.8 8.2 8.4 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein EF-hand_1 PF00036.32 EDN08160.1 - 1.8e-14 52.1 1.1 1.3e-06 27.5 0.1 3.9 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EDN08160.1 - 1.2e-13 49.8 0.9 2.4e-06 27.0 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EDN08160.1 - 4.3e-13 49.5 0.1 2.2e-05 24.8 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDN08160.1 - 5.2e-08 32.6 1.5 0.13 12.2 0.2 4.1 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EDN08160.1 - 2.8e-06 26.6 0.2 1.6e-05 24.2 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 EDN08160.1 - 0.0013 19.0 0.0 0.62 10.4 0.0 3.3 2 1 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 EDN08160.1 - 0.11 12.4 0.0 0.52 10.3 0.0 2.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EDN08160.1 - 0.13 12.4 0.0 18 5.6 0.0 2.5 2 0 0 2 2 2 0 Dockerin type I domain Mito_carr PF00153.27 EDN08161.1 - 2.2e-06 27.5 0.0 3.2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein MMR_HSR1 PF01926.23 EDN08162.1 - 0.0041 17.2 0.0 0.007 16.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1515 PF07439.11 EDN08162.1 - 0.089 12.8 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) ABC_tran PF00005.27 EDN08162.1 - 0.11 13.1 0.5 0.25 11.9 0.2 1.7 2 0 0 2 2 2 0 ABC transporter DUF87 PF01935.17 EDN08162.1 - 0.13 12.4 1.0 0.99 9.4 0.2 2.4 2 1 1 3 3 3 0 Helicase HerA, central domain AAA_22 PF13401.6 EDN08162.1 - 0.13 12.5 0.0 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF5321 PF17254.2 EDN08163.1 - 8.5e-42 142.3 4.3 1.2e-41 141.8 4.3 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5321) CCDC32 PF14989.6 EDN08163.1 - 0.014 15.4 0.6 0.023 14.7 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing 32 Qua1 PF16274.5 EDN08163.1 - 0.023 14.5 0.1 0.023 14.5 0.1 2.0 2 0 0 2 2 2 0 Qua1 domain Peptidase_C50 PF03568.17 EDN08164.1 - 1.5e-149 498.5 0.0 3.4e-149 497.3 0.0 1.6 2 0 0 2 2 2 1 Peptidase family C50 CHAT PF12770.7 EDN08164.1 - 0.00068 19.1 0.0 0.0071 15.8 0.0 2.2 2 0 0 2 2 2 1 CHAT domain Esterase PF00756.20 EDN08165.1 - 6.4e-51 173.4 0.0 7.9e-51 173.1 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 EDN08165.1 - 1.4e-05 24.7 0.0 0.00011 21.8 0.0 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EDN08165.1 - 4.5e-05 23.0 0.0 8.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EDN08165.1 - 0.00053 19.3 0.0 0.0011 18.3 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDN08165.1 - 0.0038 16.9 0.1 0.006 16.2 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 EDN08165.1 - 0.015 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 EDN08165.1 - 0.018 14.9 0.0 0.85 9.4 0.0 2.5 2 1 0 3 3 3 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EDN08165.1 - 0.019 13.9 0.0 0.045 12.6 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme PGAP1 PF07819.13 EDN08165.1 - 0.068 12.9 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Xpo1 PF08389.12 EDN08166.1 - 2.4e-40 138.0 5.4 4.5e-40 137.1 0.3 3.2 4 0 0 4 4 4 1 Exportin 1-like protein FGGY_C PF02782.16 EDN08167.1 - 5.5e-31 107.8 0.0 2.8e-30 105.5 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDN08167.1 - 9.6e-11 41.7 0.0 0.00025 20.7 0.0 2.9 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Cation_efflux PF01545.21 EDN08168.1 - 1.6e-50 171.7 7.0 1.9e-50 171.4 7.0 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EDN08168.1 - 0.001 19.2 0.3 0.011 15.8 0.0 2.2 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter SIR2 PF02146.17 EDN08169.1 - 2.5e-32 112.2 0.0 4.1e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Sir2 family Pkinase PF00069.25 EDN08170.1 - 9.6e-75 251.3 0.0 1.2e-74 251.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08170.1 - 3.7e-37 128.0 0.0 5.1e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN08170.1 - 0.0012 17.9 0.0 0.019 13.9 0.0 2.2 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDN08170.1 - 0.0038 16.6 0.5 0.017 14.4 0.1 2.2 2 1 1 3 3 3 1 Kinase-like Kdo PF06293.14 EDN08170.1 - 0.018 14.4 0.2 0.049 13.0 0.2 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN08170.1 - 0.11 12.4 4.6 0.028 14.3 0.5 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family TPR_17 PF13431.6 EDN08171.1 - 0.00047 20.4 1.3 0.35 11.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat DALR_2 PF09190.11 EDN08171.1 - 0.068 13.6 0.1 0.38 11.3 0.0 2.3 2 0 0 2 2 2 0 DALR domain TPR_11 PF13414.6 EDN08171.1 - 0.072 12.8 0.1 1.5 8.5 0.0 3.2 3 0 0 3 3 3 0 TPR repeat OSR1_C PF12202.8 EDN08171.1 - 1.1 9.5 3.2 4.1 7.7 1.8 2.6 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain TPR_14 PF13428.6 EDN08171.1 - 5.2 8.2 8.3 17 6.6 0.0 5.0 6 1 0 6 6 6 0 Tetratricopeptide repeat NTF2 PF02136.20 EDN08173.1 - 1.2e-25 90.3 0.2 2.2e-25 89.5 0.2 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EDN08173.1 - 3e-06 27.0 0.1 6.2e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDN08173.1 - 0.13 12.3 1.1 0.21 11.6 0.1 1.9 2 0 0 2 2 2 0 RNA binding motif NTPase_1 PF03266.15 EDN08174.1 - 0.0081 16.1 0.1 0.01 15.7 0.1 1.2 1 0 0 1 1 1 1 NTPase HTH_psq PF05225.16 EDN08174.1 - 0.089 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HSP90 PF00183.18 EDN08176.1 - 5.1e-221 735.0 31.1 6.3e-221 734.8 31.1 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EDN08176.1 - 7.4e-15 55.4 0.1 1.4e-14 54.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDN08176.1 - 1.4e-10 41.1 0.1 1.4e-10 41.1 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 EDN08176.1 - 0.041 13.9 0.5 0.27 11.3 0.1 2.5 2 0 0 2 2 2 0 Tumour suppressor protein Septin PF00735.18 EDN08177.1 - 8.5e-14 51.5 0.0 1e-09 38.1 0.0 2.3 2 0 0 2 2 2 2 Septin AAA_16 PF13191.6 EDN08177.1 - 0.009 16.4 0.0 0.032 14.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDN08177.1 - 0.01 15.7 0.1 0.19 11.6 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase ABC_tran PF00005.27 EDN08177.1 - 0.016 15.7 0.0 0.033 14.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA PF00004.29 EDN08177.1 - 0.028 14.9 0.0 0.049 14.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDN08177.1 - 0.031 13.5 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Gtr1_RagA PF04670.12 EDN08177.1 - 0.045 13.1 0.2 4.1 6.7 0.1 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region DUF815 PF05673.13 EDN08177.1 - 0.072 12.2 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 EDN08177.1 - 0.078 12.7 0.1 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDN08177.1 - 0.083 12.8 0.2 0.27 11.1 0.1 1.9 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 EDN08177.1 - 0.087 13.1 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EDN08177.1 - 0.093 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EDN08177.1 - 0.094 12.1 0.0 0.35 10.2 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI G-alpha PF00503.20 EDN08177.1 - 0.14 11.3 0.1 0.34 10.0 0.0 1.6 1 1 0 1 1 1 0 G-protein alpha subunit PRK PF00485.18 EDN08177.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_19 PF13245.6 EDN08177.1 - 0.19 12.0 0.0 0.37 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDN08177.1 - 0.2 11.1 0.0 0.37 10.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF3435 PF11917.8 EDN08178.1 - 2.2e-45 155.4 3.3 2.2e-45 155.4 3.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) Jnk-SapK_ap_N PF09744.9 EDN08178.1 - 0.098 12.9 6.5 0.39 10.9 2.0 3.1 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 BTB PF00651.31 EDN08179.1 - 4.7e-05 23.6 0.1 0.00059 20.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Trypan_PARP PF05887.11 EDN08179.1 - 0.0026 17.7 4.2 0.0043 17.0 4.2 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) AAA PF00004.29 EDN08181.1 - 1.3e-13 51.5 0.3 1.8e-06 28.4 0.0 2.5 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN08181.1 - 4.2e-07 30.5 1.0 4.9e-06 27.0 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EDN08181.1 - 0.00013 22.2 0.3 0.0018 18.5 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 EDN08181.1 - 0.002 18.7 0.0 0.0056 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDN08181.1 - 0.0037 17.3 0.0 0.0086 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDN08181.1 - 0.024 14.8 0.0 0.059 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EDN08181.1 - 0.028 14.2 0.1 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Ribosomal_60s PF00428.19 EDN08181.1 - 0.039 14.6 0.0 1.5 9.5 0.1 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Zeta_toxin PF06414.12 EDN08181.1 - 0.039 13.2 0.1 2.2 7.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 EDN08181.1 - 0.071 13.5 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ResIII PF04851.15 EDN08181.1 - 0.093 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EDN08181.1 - 0.1 12.3 0.2 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EDN08181.1 - 0.15 11.3 0.1 0.31 10.4 0.1 1.4 1 0 0 1 1 1 0 KaiC Atg14 PF10186.9 EDN08183.1 - 0.0077 15.4 1.1 0.93 8.5 2.0 2.1 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 YL1 PF05764.13 EDN08183.1 - 0.6 10.2 16.7 0.24 11.5 13.1 1.8 2 0 0 2 2 2 0 YL1 nuclear protein CDC45 PF02724.14 EDN08183.1 - 8 4.6 13.4 14 3.9 13.4 1.3 1 0 0 1 1 1 0 CDC45-like protein DivIC PF04977.15 EDN08184.1 - 0.03 14.1 7.4 0.21 11.4 1.7 2.3 1 1 1 2 2 2 0 Septum formation initiator Spc7 PF08317.11 EDN08184.1 - 0.032 13.1 3.9 0.046 12.6 3.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ZapB PF06005.12 EDN08184.1 - 0.053 14.0 4.4 0.12 12.8 4.4 1.6 1 0 0 1 1 1 0 Cell division protein ZapB Rieske PF00355.26 EDN08184.1 - 0.15 12.0 0.6 0.46 10.4 0.6 1.9 1 1 0 1 1 1 0 Rieske [2Fe-2S] domain HLH PF00010.26 EDN08185.1 - 1.2e-13 50.8 0.1 2.4e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain FAM76 PF16046.5 EDN08185.1 - 0.18 11.1 1.1 0.42 9.9 1.1 1.6 1 0 0 1 1 1 0 FAM76 protein ZapB PF06005.12 EDN08185.1 - 0.4 11.2 2.8 0.29 11.6 0.2 2.0 2 0 0 2 2 2 0 Cell division protein ZapB AAT PF03417.16 EDN08187.1 - 7.1e-08 32.4 0.0 1.1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase DUF2513 PF10711.9 EDN08187.1 - 0.057 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) DDE_1 PF03184.19 EDN08188.1 - 8.9e-23 80.8 0.0 1.8e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN08188.1 - 3.9e-05 23.5 0.0 0.00079 19.2 0.0 2.7 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN08188.1 - 0.0017 18.4 0.0 0.0069 16.4 0.0 2.2 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN08188.1 - 0.025 14.3 0.5 0.025 14.3 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN08188.1 - 0.041 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) SpoIIE PF07228.12 EDN08190.1 - 6.7e-05 22.9 0.3 0.00079 19.4 0.3 2.4 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EDN08190.1 - 0.01 15.5 0.0 0.96 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein phosphatase 2C WD40 PF00400.32 EDN08191.1 - 1.2e-16 60.8 7.0 0.0067 17.3 0.1 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN08191.1 - 2.9e-07 30.7 0.9 0.0056 17.0 0.3 4.4 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN08191.1 - 6.8e-05 21.7 3.8 0.00056 18.7 0.2 2.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 DASH_Dad1 PF08649.10 EDN08192.1 - 0.064 13.5 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Dad1 FAM76 PF16046.5 EDN08192.1 - 5.3 6.3 13.1 0.082 12.2 5.3 1.8 2 0 0 2 2 2 0 FAM76 protein RRN3 PF05327.11 EDN08193.1 - 2.4e-122 409.3 0.0 9.1e-86 288.6 0.0 4.4 2 1 3 5 5 5 3 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_3 PF07859.13 EDN08194.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold tRNA-synt_2 PF00152.20 EDN08195.1 - 3.3e-67 226.8 0.0 5.6e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EDN08195.1 - 9.7e-17 60.9 0.0 1.4e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EDN08195.1 - 1.1e-06 28.5 0.8 7.2e-05 22.7 0.6 2.4 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDN08195.1 - 0.0019 17.7 0.9 1.8 7.9 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) P34-Arc PF04045.14 EDN08196.1 - 7.8e-109 363.0 0.0 9.4e-109 362.7 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc WD40 PF00400.32 EDN08197.1 - 5.3e-50 166.3 29.8 5.3e-07 30.2 0.2 11.3 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.12 EDN08197.1 - 1.8e-21 76.5 0.0 4.2e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EDN08197.1 - 3.2e-19 69.0 4.2 0.028 14.7 0.0 9.0 5 2 5 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN08197.1 - 1.9e-06 27.1 7.2 1 8.2 0.2 5.4 4 2 1 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EDN08197.1 - 8e-05 22.1 0.4 1.1 8.5 0.1 4.0 3 2 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 EDN08197.1 - 0.0007 18.4 8.4 0.14 10.7 0.0 5.2 5 2 0 5 5 5 2 Nucleoporin Nup120/160 Frtz PF11768.8 EDN08197.1 - 0.0066 14.8 0.0 0.18 10.1 0.0 2.5 2 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz CDtoxinA PF03498.14 EDN08197.1 - 0.015 14.9 0.1 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 Cytolethal distending toxin A/C domain Nucleoporin_N PF08801.11 EDN08197.1 - 0.018 13.8 3.1 0.094 11.4 0.2 3.4 3 2 1 4 4 4 0 Nup133 N terminal like WLM PF08325.10 EDN08198.1 - 5.2e-64 215.9 0.6 7.8e-64 215.3 0.1 1.6 2 0 0 2 2 2 1 WLM domain zf-RanBP PF00641.18 EDN08198.1 - 0.00021 20.6 21.8 0.0007 18.9 3.8 3.1 2 1 0 3 3 3 3 Zn-finger in Ran binding protein and others SprT-like PF10263.9 EDN08198.1 - 0.013 15.3 0.2 0.04 13.8 0.1 1.9 2 0 0 2 2 2 0 SprT-like family DUF45 PF01863.17 EDN08198.1 - 0.015 15.3 3.0 0.015 15.3 3.0 2.0 3 0 0 3 3 3 0 Protein of unknown function DUF45 DZR PF12773.7 EDN08198.1 - 0.067 13.2 9.6 0.66 10.1 10.0 2.1 1 1 2 3 3 3 0 Double zinc ribbon AIM3 PF17096.5 EDN08198.1 - 0.17 12.9 1.8 0.33 11.9 1.8 1.5 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 zf-Sec23_Sec24 PF04810.15 EDN08198.1 - 0.76 9.9 7.3 2.7 8.1 0.0 3.2 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger Rubredoxin PF00301.20 EDN08198.1 - 6.4 6.9 10.6 3.6 7.7 0.6 3.5 3 0 0 3 3 3 0 Rubredoxin TrbC PF04956.13 EDN08199.1 - 0.024 14.9 0.0 0.1 12.8 0.0 1.9 2 0 0 2 2 2 0 TrbC/VIRB2 family C1_1 PF00130.22 EDN08200.1 - 0.074 13.0 9.2 0.38 10.7 1.6 2.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Far-17a_AIG1 PF04750.14 EDN08201.1 - 0.00084 18.7 7.0 0.00084 18.7 7.0 3.6 1 1 3 4 4 4 2 FAR-17a/AIG1-like protein DUF4083 PF13314.6 EDN08201.1 - 0.95 9.5 0.0 0.95 9.5 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) Sel1 PF08238.12 EDN08204.1 - 5.6e-13 49.1 7.0 0.0038 17.9 0.9 3.8 3 0 0 3 3 3 3 Sel1 repeat Chromo PF00385.24 EDN08206.1 - 0.00029 20.7 0.0 0.00076 19.3 0.0 1.7 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase_fungal PF17667.1 EDN08207.1 - 1.7e-125 419.0 0.0 2.1e-125 418.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Caskin-Pro-rich PF16907.5 EDN08207.1 - 0.034 14.7 6.4 5 7.7 3.3 2.4 2 0 0 2 2 2 0 Proline rich region of Caskin proteins SLATT_5 PF18160.1 EDN08208.1 - 0.01 15.2 0.5 0.01 15.2 0.5 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 NPAT_C PF15712.5 EDN08208.1 - 0.012 14.3 0.2 0.016 13.9 0.2 1.1 1 0 0 1 1 1 0 NPAT C terminus SOAR PF16533.5 EDN08208.1 - 0.037 14.0 2.2 0.062 13.3 1.0 1.9 1 1 1 2 2 2 0 STIM1 Orai1-activating region DUF349 PF03993.12 EDN08208.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Myb_DNA-binding PF00249.31 EDN08210.1 - 1.5e-12 47.5 1.2 5.3e-11 42.5 0.0 2.5 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08210.1 - 1.2e-05 25.4 1.5 5e-05 23.5 0.6 2.4 2 1 0 2 2 2 1 Myb-like DNA-binding domain AGOG PF09171.10 EDN08210.1 - 0.019 14.3 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 N-glycosylase/DNA lyase TIR PF01582.20 EDN08210.1 - 0.07 12.9 2.6 0.1 12.4 2.6 1.4 1 1 0 1 1 1 0 TIR domain Zn_clus PF00172.18 EDN08213.1 - 1.6e-07 31.4 8.5 1.6e-07 31.4 8.5 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rnf-Nqr PF02508.14 EDN08213.1 - 0.12 12.4 1.6 0.26 11.3 1.6 1.5 1 1 0 1 1 1 0 Rnf-Nqr subunit, membrane protein GvpG PF05120.12 EDN08214.1 - 0.042 13.9 1.7 0.12 12.3 1.7 1.8 1 0 0 1 1 1 0 Gas vesicle protein G HSCB_C PF07743.13 EDN08214.1 - 0.075 13.5 7.8 6.4 7.3 0.4 3.8 4 0 0 4 4 4 0 HSCB C-terminal oligomerisation domain CP2 PF04516.15 EDN08215.1 - 4.3e-71 238.9 0.0 1.1e-69 234.3 0.0 2.2 2 0 0 2 2 2 1 CP2 transcription factor bZIP_2 PF07716.15 EDN08215.1 - 0.0088 16.1 6.3 0.065 13.3 1.0 2.3 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EDN08215.1 - 0.043 13.9 7.9 0.064 13.4 4.1 2.3 2 0 0 2 2 2 0 bZIP transcription factor Tegument_dsDNA PF12818.7 EDN08216.1 - 0.085 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein Lac_bphage_repr PF06543.12 EDN08218.1 - 0.097 12.7 0.4 0.26 11.3 0.4 1.7 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor DUF1388 PF07142.12 EDN08219.1 - 0.0088 16.0 21.4 0.72 9.9 2.2 3.8 1 1 3 4 4 4 4 Repeat of unknown function (DUF1388) Collagen PF01391.18 EDN08219.1 - 0.71 9.7 11.2 22 4.9 11.2 2.9 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) HAUS-augmin3 PF14932.6 EDN08220.1 - 5.7e-05 22.8 1.1 7.7e-05 22.4 1.1 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 zf-C3HC4_3 PF13920.6 EDN08220.1 - 0.00013 21.7 10.2 0.00019 21.2 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UPF0242 PF06785.11 EDN08220.1 - 0.00014 22.0 1.1 0.00021 21.5 1.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DegS PF05384.11 EDN08220.1 - 0.00026 20.5 2.3 0.00039 20.0 2.3 1.2 1 0 0 1 1 1 1 Sensor protein DegS zf-C3HC4 PF00097.25 EDN08220.1 - 0.00056 19.7 8.2 0.0011 18.8 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Lebercilin PF15619.6 EDN08220.1 - 0.0015 18.2 2.7 0.012 15.3 2.6 1.9 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF4200 PF13863.6 EDN08220.1 - 0.0027 18.1 5.6 0.0044 17.4 5.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Troponin PF00992.20 EDN08220.1 - 0.0032 17.8 4.8 0.0051 17.1 4.8 1.3 1 0 0 1 1 1 1 Troponin Fib_alpha PF08702.10 EDN08220.1 - 0.011 16.0 0.4 0.015 15.5 0.4 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-C3HC4_2 PF13923.6 EDN08220.1 - 0.011 15.5 8.2 0.022 14.6 8.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DivIC PF04977.15 EDN08220.1 - 0.012 15.4 1.2 0.021 14.6 1.2 1.4 1 0 0 1 1 1 0 Septum formation initiator zf-RING_5 PF14634.6 EDN08220.1 - 0.014 15.4 8.2 0.023 14.6 8.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DUF4407 PF14362.6 EDN08220.1 - 0.014 14.8 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Interferon PF00143.19 EDN08220.1 - 0.014 15.6 0.0 0.018 15.2 0.0 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain Fez1 PF06818.15 EDN08220.1 - 0.016 15.6 2.4 0.024 15.1 2.4 1.2 1 0 0 1 1 1 0 Fez1 Macoilin PF09726.9 EDN08220.1 - 0.019 13.5 2.8 0.024 13.2 2.8 1.1 1 0 0 1 1 1 0 Macoilin family ADIP PF11559.8 EDN08220.1 - 0.027 14.6 3.0 0.049 13.7 3.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 EDN08220.1 - 0.028 13.8 2.1 0.039 13.3 2.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EDN08220.1 - 0.037 14.4 1.5 1.9 8.9 0.4 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4164 PF13747.6 EDN08220.1 - 0.068 13.5 5.0 0.12 12.6 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) CENP-Q PF13094.6 EDN08220.1 - 0.081 13.1 2.2 0.11 12.6 2.2 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Exonuc_VII_L PF02601.15 EDN08220.1 - 0.1 12.1 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Trimer_CC PF08954.11 EDN08220.1 - 0.11 12.1 5.7 0.24 11.0 5.7 1.6 1 0 0 1 1 1 0 Trimerisation motif DUF848 PF05852.11 EDN08220.1 - 0.17 12.0 3.2 0.28 11.3 3.2 1.4 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1192 PF06698.11 EDN08220.1 - 0.18 11.9 2.9 0.37 10.9 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) BLOC1_2 PF10046.9 EDN08220.1 - 0.19 12.0 1.5 0.28 11.5 1.5 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2730 PF10805.8 EDN08220.1 - 0.21 11.7 0.7 0.4 10.8 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) TMF_TATA_bd PF12325.8 EDN08220.1 - 0.31 11.3 5.0 0.81 9.9 5.0 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Metal_resist PF13801.6 EDN08220.1 - 3.3 7.9 7.7 0.16 12.2 2.3 1.5 2 0 0 2 2 1 0 Heavy-metal resistance zf-RING_2 PF13639.6 EDN08220.1 - 3.8 7.9 13.1 6.5 7.2 13.1 1.4 1 0 0 1 1 1 0 Ring finger domain bZIP_1 PF00170.21 EDN08220.1 - 7.2 6.8 11.0 0.16 12.1 3.7 2.1 2 1 0 2 2 1 0 bZIP transcription factor DUF3435 PF11917.8 EDN08221.1 - 8.7e-127 423.5 0.0 1.2e-126 423.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) HTH_7 PF02796.15 EDN08222.1 - 9.6e-06 25.6 0.0 7.8e-05 22.7 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 EDN08222.1 - 2e-05 24.5 0.1 0.00023 21.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 EDN08222.1 - 2.1e-05 24.2 0.1 0.0011 18.7 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 EDN08222.1 - 3.2e-05 23.6 0.1 0.00042 20.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_33 PF13592.6 EDN08222.1 - 0.00013 21.5 0.0 0.00048 19.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix PAX PF00292.18 EDN08222.1 - 0.01 15.8 0.0 0.015 15.2 0.0 1.4 1 1 0 1 1 1 0 'Paired box' domain Terminase_5 PF06056.12 EDN08222.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_28 PF13518.6 EDN08222.1 - 0.17 12.0 0.1 19 5.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Trypan_PARP PF05887.11 EDN08223.1 - 0.0016 18.5 9.2 0.0016 18.5 9.2 2.1 2 0 0 2 2 2 2 Procyclic acidic repetitive protein (PARP) Nucleo_P87 PF07267.11 EDN08223.1 - 0.08 11.8 2.5 0.098 11.5 2.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RseA_N PF03872.13 EDN08223.1 - 0.21 12.1 5.9 2.2 8.8 2.3 3.1 2 1 0 2 2 2 0 Anti sigma-E protein RseA, N-terminal domain DUF3435 PF11917.8 EDN08224.1 - 3e-129 431.6 0.1 1.2e-116 390.2 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) DUF3682 PF12446.8 EDN08224.1 - 6.4 7.3 9.0 12 6.4 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Kdo PF06293.14 EDN08225.1 - 0.0005 19.5 0.0 0.00062 19.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDN08225.1 - 0.033 13.5 0.0 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain DDE_1 PF03184.19 EDN08227.1 - 4.5e-30 104.6 0.0 2e-29 102.5 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN08227.1 - 0.0014 18.4 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3723 PF12520.8 EDN08229.1 - 9.2e-90 301.7 32.8 3.2e-47 161.4 0.0 5.3 2 2 2 5 5 5 3 Protein of unknown function (DUF3723) DUF3435 PF11917.8 EDN08230.1 - 7.3e-160 532.5 0.7 9.5e-160 532.1 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-Di19 PF05605.12 EDN08230.1 - 0.057 13.7 2.0 0.19 12.0 0.6 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3712 PF12505.8 EDN08231.1 - 4.8e-26 91.5 2.2 1.4e-25 90.0 0.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) LEA_2 PF03168.13 EDN08231.1 - 0.0063 17.0 0.0 0.02 15.4 0.0 1.9 2 0 0 2 2 2 1 Late embryogenesis abundant protein DUF1279 PF06916.13 EDN08231.1 - 0.13 12.8 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) Glyco_hydro_18 PF00704.28 EDN08232.1 - 2e-51 175.6 0.0 2.4e-51 175.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 zf-CCCH PF00642.24 EDN08233.1 - 4.7e-20 71.0 29.4 2.3e-08 33.7 0.8 5.2 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDN08233.1 - 5.4e-17 61.2 29.4 1.1e-05 25.3 2.2 5.2 5 0 0 5 5 5 5 Zinc finger domain Torus PF16131.5 EDN08233.1 - 1.3e-10 42.0 28.7 0.00011 22.9 2.2 5.4 1 1 4 5 5 5 5 Torus domain zf-CCCH_4 PF18044.1 EDN08233.1 - 2.5e-06 27.1 30.9 2.7e-06 27.0 0.8 5.2 5 0 0 5 5 5 3 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDN08233.1 - 0.23 11.7 10.5 7.9 6.7 3.6 3.4 2 1 1 3 3 3 0 Zinc-finger containing family zf-C3H1 PF10650.9 EDN08233.1 - 1.1 9.0 0.1 1.1 9.0 0.1 3.8 4 0 0 4 4 4 0 Putative zinc-finger domain Flavodoxin_2 PF02525.17 EDN08235.1 - 1.8e-07 31.1 0.0 2.2e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EDN08235.1 - 1.8e-07 31.0 0.0 2.5e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EDN08235.1 - 0.00071 19.8 0.1 0.0036 17.5 0.1 2.1 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EDN08235.1 - 0.091 13.0 0.0 0.81 9.9 0.0 2.0 1 1 1 2 2 2 0 Flavodoxin domain NPL4 PF05021.15 EDN08236.1 - 3.7e-125 417.4 0.0 1.5e-123 412.1 0.0 2.1 1 1 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EDN08236.1 - 2.4e-69 232.0 0.0 4.2e-69 231.3 0.0 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region DUF2417 PF10329.9 EDN08237.1 - 1.5e-78 263.5 0.0 2.3e-78 262.9 0.0 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.7 EDN08239.1 - 3.1e-21 77.0 0.0 5.7e-21 76.1 0.0 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN08239.1 - 1.2e-07 31.7 0.0 0.0006 19.5 0.0 2.3 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN08239.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EDN08239.1 - 0.044 13.7 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Cutinase PF01083.22 EDN08239.1 - 0.076 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Cutinase PGAP1 PF07819.13 EDN08239.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein WD40 PF00400.32 EDN08240.1 - 1.6e-47 158.5 25.0 4.9e-09 36.7 0.3 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EDN08240.1 - 1.3e-38 132.2 0.1 1.9e-38 131.6 0.1 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EDN08240.1 - 6e-12 45.7 0.3 0.0099 16.2 0.0 5.2 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN08240.1 - 6.7e-05 21.7 1.4 0.041 12.5 0.0 3.7 3 1 1 4 4 4 1 Nucleoporin Nup120/160 LisH PF08513.11 EDN08240.1 - 0.0015 18.4 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 EDN08240.1 - 0.006 15.6 0.0 0.26 10.2 0.0 2.8 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EDN08240.1 - 0.01 14.6 0.0 0.78 8.4 0.0 3.3 2 1 0 2 2 2 0 Nup133 N terminal like PALB2_WD40 PF16756.5 EDN08240.1 - 2.2 7.1 5.0 0.29 10.0 0.8 1.6 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Med11 PF10280.9 EDN08241.1 - 3.7e-42 144.0 0.0 4.4e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Mediator complex protein Prd1-P2 PF09214.11 EDN08241.1 - 0.1 11.3 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Prd1, adsorption protein P2 F_actin_cap_B PF01115.17 EDN08242.1 - 3.1e-106 354.3 0.0 3.8e-106 354.1 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Helicase_C PF00271.31 EDN08243.1 - 1.3e-20 73.7 0.0 2.7e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN08243.1 - 1.4e-05 25.1 0.0 3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDN08243.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EDN08243.1 - 0.0026 17.0 0.0 0.0067 15.7 0.0 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DPM2 PF07297.12 EDN08247.1 - 1.7e-31 108.3 0.7 2.3e-31 107.9 0.7 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EDN08247.1 - 0.0067 16.3 0.7 0.0091 15.9 0.7 1.2 1 0 0 1 1 1 1 PIG-P DUF4229 PF14012.6 EDN08247.1 - 0.023 14.8 0.2 0.023 14.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Phage_holin_3_6 PF07332.11 EDN08247.1 - 0.051 13.6 1.5 0.061 13.4 1.5 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III COX14 PF14880.6 EDN08247.1 - 0.075 12.9 0.0 0.075 12.9 0.0 2.0 2 0 0 2 2 2 0 Cytochrome oxidase c assembly LapA_dom PF06305.11 EDN08247.1 - 0.11 12.3 0.1 0.11 12.3 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain MA3 PF02847.17 EDN08248.1 - 9e-29 99.7 0.0 2.3e-28 98.4 0.0 1.8 1 0 0 1 1 1 1 MA3 domain DUF5523 PF17661.1 EDN08248.1 - 3.6 7.2 9.8 0.58 9.8 5.5 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RRM_1 PF00076.22 EDN08249.1 - 1.9e-16 59.6 0.0 1.9e-10 40.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDN08249.1 - 0.02 15.0 0.0 1.9 8.6 0.1 2.4 2 0 0 2 2 2 0 Limkain b1 DUF3932 PF13068.6 EDN08249.1 - 0.16 12.2 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3932) DUF1772 PF08592.11 EDN08250.1 - 1.2e-08 35.4 0.5 1.7e-08 34.8 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Glucosamine_iso PF01182.20 EDN08252.1 - 5.4e-69 232.5 0.0 6.3e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF3458_C PF17432.2 EDN08253.1 - 0.028 13.8 0.4 0.041 13.3 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3458_C) ARM repeats WD40 PF00400.32 EDN08255.1 - 6.1e-21 74.3 13.0 6.8e-06 26.7 0.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN08255.1 - 0.00049 20.3 0.0 0.044 14.1 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain ALC PF17527.2 EDN08255.1 - 0.28 10.8 0.0 0.28 10.8 0.0 1.6 2 0 0 2 2 2 0 Phage ALC protein TPR_9 PF13371.6 EDN08256.1 - 0.012 15.8 0.6 0.025 14.7 0.6 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat YqeY PF09424.10 EDN08256.1 - 0.048 13.7 0.1 0.08 13.0 0.1 1.3 1 0 0 1 1 1 0 Yqey-like protein Phage_rep_O PF04492.13 EDN08256.1 - 0.057 14.0 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage replication protein O RabGAP-TBC PF00566.18 EDN08257.1 - 1.2e-06 28.4 0.2 1.5e-06 28.1 0.2 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 EDN08259.1 - 1.6e-13 49.4 2.4 5.6e-06 25.9 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EDN08259.1 - 1.6e-11 42.9 4.0 3.1e-05 23.2 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EDN08259.1 - 5.5e-09 36.4 0.3 1.4e-08 35.1 0.3 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EDN08259.1 - 1.7e-08 33.5 6.0 0.00042 19.7 1.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EDN08259.1 - 4.2e-06 26.5 0.1 0.037 13.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EDN08259.1 - 0.0048 17.2 0.0 2.1 8.8 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain Afi1 PF07792.12 EDN08260.1 - 1.8e-42 145.0 0.2 3.5e-42 144.0 0.2 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EDN08260.1 - 4.4e-37 126.5 0.0 7.3e-37 125.8 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EDN08260.1 - 2.4e-09 36.4 0.0 0.002 16.9 0.1 4.0 4 1 1 5 5 5 3 Transport protein Avl9 Nucleo_LEF-12 PF06256.11 EDN08263.1 - 0.18 11.6 0.0 0.4 10.4 0.0 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus LEF-12 protein Formyl_trans_N PF00551.19 EDN08264.1 - 8.4e-41 139.7 0.1 9.9e-41 139.5 0.1 1.1 1 0 0 1 1 1 1 Formyl transferase Phos_pyr_kin PF08543.12 EDN08265.1 - 1.2e-11 44.5 0.0 2.7e-11 43.3 0.0 1.7 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EDN08265.1 - 2.3e-07 30.4 1.0 1.4e-06 27.8 0.0 2.5 3 0 0 3 3 3 1 pfkB family carbohydrate kinase DUF4805 PF16063.5 EDN08265.1 - 0.0044 16.4 1.4 0.0085 15.5 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4805) dUTPase PF00692.19 EDN08266.1 - 1.7e-44 150.6 0.0 2.1e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 dUTPase DCD PF06559.11 EDN08266.1 - 0.021 13.6 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) APH PF01636.23 EDN08267.1 - 1.1e-41 143.3 0.1 5e-41 141.2 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN08267.1 - 6.1e-06 25.7 0.0 9.9e-05 21.8 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN08267.1 - 1.9e-05 24.4 0.0 3.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EDN08267.1 - 0.00016 21.1 0.0 0.00031 20.2 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 EDN08267.1 - 0.022 14.3 0.0 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Fructosamin_kin PF03881.14 EDN08267.1 - 0.023 13.9 0.0 3.8 6.6 0.0 2.3 1 1 1 2 2 2 0 Fructosamine kinase DUF1679 PF07914.11 EDN08267.1 - 0.084 11.7 0.0 0.18 10.6 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) zf-C2H2 PF00096.26 EDN08269.1 - 7.9e-10 38.6 11.2 0.0019 18.6 1.8 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN08269.1 - 1.9e-05 24.9 8.0 0.64 10.6 0.2 4.0 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN08269.1 - 0.00087 19.9 10.7 0.034 15.0 1.5 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 EDN08269.1 - 1.1 9.6 10.7 0.23 11.8 1.1 2.9 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding PQ-loop PF04193.14 EDN08270.1 - 2.2e-37 126.6 5.2 1e-19 70.0 0.5 2.6 2 0 0 2 2 2 2 PQ loop repeat Cytochrom_B561 PF03188.16 EDN08271.1 - 0.00034 20.8 10.3 0.00071 19.7 10.3 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Ribosomal_L29e PF01779.17 EDN08272.1 - 4e-17 62.2 8.7 8.2e-17 61.2 8.7 1.6 1 0 0 1 1 1 1 Ribosomal L29e protein family ANAPC4_WD40 PF12894.7 EDN08273.1 - 0.0018 18.6 0.1 0.0087 16.3 0.0 2.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN08273.1 - 0.048 14.5 0.1 19 6.3 0.0 4.3 5 0 0 5 5 5 0 WD domain, G-beta repeat NCBP3 PF10309.9 EDN08274.1 - 4e-21 74.6 0.1 7.1e-21 73.8 0.1 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Myb_DNA-binding PF00249.31 EDN08275.1 - 3.1e-12 46.5 4.2 4.9e-09 36.3 0.2 3.2 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08275.1 - 1.4e-07 31.6 4.2 0.0019 18.4 0.2 3.2 1 1 2 3 3 3 2 Myb-like DNA-binding domain DUF2774 PF11242.8 EDN08275.1 - 0.0019 18.3 0.0 0.0034 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2774) HTH_23 PF13384.6 EDN08275.1 - 0.13 12.1 0.2 0.27 11.1 0.2 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EDN08275.1 - 0.19 11.4 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Glyco_transf_41 PF13844.6 EDN08276.1 - 1.6e-105 353.3 0.0 5.1e-54 183.5 0.0 3.1 2 1 1 3 3 3 3 Glycosyl transferase family 41 TPR_2 PF07719.17 EDN08276.1 - 7.9e-16 56.8 15.7 0.0012 18.8 0.1 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EDN08276.1 - 8.8e-16 57.0 14.7 0.0026 17.5 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDN08276.1 - 9.2e-14 50.9 23.2 0.00024 20.7 0.1 6.8 4 2 3 7 7 7 4 TPR repeat TPR_10 PF13374.6 EDN08276.1 - 6.5e-10 38.6 14.2 0.02 14.8 0.3 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDN08276.1 - 8.7e-10 38.0 4.6 0.0068 16.5 0.0 5.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN08276.1 - 3.5e-09 36.8 13.9 0.0019 18.4 0.9 5.6 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDN08276.1 - 2e-08 33.6 7.1 0.13 12.3 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDN08276.1 - 2.3e-08 34.2 8.5 0.015 16.0 0.1 5.5 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDN08276.1 - 3.9e-08 33.8 15.4 0.015 15.9 0.9 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDN08276.1 - 5.5e-08 33.2 12.2 0.0031 18.0 1.6 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDN08276.1 - 8.3e-08 32.1 7.2 0.14 12.6 0.3 5.3 4 0 0 4 4 4 3 Tetratricopeptide repeat BTAD PF03704.17 EDN08276.1 - 0.00021 21.8 3.1 0.025 15.0 0.0 3.1 4 0 0 4 4 2 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 EDN08276.1 - 0.0008 19.6 0.2 0.031 14.5 0.1 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDN08276.1 - 0.0028 17.8 6.9 0.49 10.6 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDN08276.1 - 0.014 14.6 1.9 1.9 7.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDN08276.1 - 0.053 14.2 3.6 8.9 7.3 0.6 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Coatomer_E PF04733.14 EDN08276.1 - 0.21 11.0 0.0 1.2 8.5 0.0 1.9 2 0 0 2 2 2 0 Coatomer epsilon subunit Ribosomal_L11 PF00298.19 EDN08278.1 - 0.00077 19.9 0.0 0.001 19.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Sec23_trunk PF04811.15 EDN08279.1 - 6.4e-82 274.8 0.0 1.2e-81 273.9 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDN08279.1 - 9.6e-31 106.4 0.1 2.2e-30 105.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDN08279.1 - 6.7e-25 86.9 0.1 2.5e-24 85.1 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EDN08279.1 - 4.6e-11 42.5 0.0 1.2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat DNA_primase_lrg PF04104.14 EDN08280.1 - 1.5e-86 290.1 0.0 2.1e-86 289.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit ADK PF00406.22 EDN08281.1 - 4e-35 121.1 0.0 3.1e-33 115.0 0.0 2.1 1 1 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 EDN08281.1 - 1e-15 57.4 0.0 1.7e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EDN08281.1 - 1.8e-14 54.3 0.0 1.2e-13 51.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDN08281.1 - 0.0015 19.0 0.0 0.0084 16.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDN08281.1 - 0.0058 16.8 0.1 0.031 14.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 EDN08281.1 - 0.078 11.9 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EDN08281.1 - 0.16 12.3 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain SNase PF00565.17 EDN08282.1 - 3.6e-21 75.7 0.0 4.6e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Mito_carr PF00153.27 EDN08283.1 - 3.8e-27 94.1 0.1 1.1e-14 54.1 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein CNDH2_N PF06278.11 EDN08283.1 - 0.08 13.2 0.2 0.13 12.5 0.2 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal ADK PF00406.22 EDN08284.1 - 5.6e-13 49.3 0.0 6.8e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDN08284.1 - 9.6e-10 39.0 0.0 1.2e-09 38.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDN08284.1 - 0.0013 19.3 0.0 0.0013 19.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDN08284.1 - 0.0049 17.0 0.0 0.0056 16.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EDN08284.1 - 0.0085 15.1 0.0 0.0097 14.9 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EDN08284.1 - 0.015 15.6 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDN08284.1 - 0.039 14.2 0.0 0.039 14.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN08284.1 - 0.06 13.3 0.0 0.078 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Guanylate_kin PF00625.21 EDN08284.1 - 0.077 12.7 0.0 0.09 12.5 0.0 1.1 1 0 0 1 1 1 0 Guanylate kinase Peptidase_C2 PF00648.21 EDN08285.1 - 1e-19 70.7 0.0 1.5e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EDN08285.1 - 0.017 15.4 0.0 0.26 11.6 0.0 2.5 3 0 0 3 3 3 0 Calpain large subunit, domain III Vta1 PF04652.16 EDN08286.1 - 6.9e-55 185.0 1.8 8.6e-55 184.7 1.8 1.1 1 0 0 1 1 1 1 Vta1 like Epimerase PF01370.21 EDN08287.1 - 1.1e-21 77.5 0.0 1.5e-21 77.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EDN08287.1 - 2.2e-07 30.3 0.0 3.4e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EDN08287.1 - 7.5e-06 25.2 0.0 1.5e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDN08287.1 - 1.5e-05 24.6 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Topoisom_I_N PF02919.15 EDN08288.1 - 8.5e-97 322.8 1.6 8.5e-97 322.8 1.6 2.6 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 EDN08288.1 - 1.7e-57 194.4 0.6 2.8e-57 193.6 0.6 1.3 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core DUF4604 PF15377.6 EDN08288.1 - 0.022 15.2 26.3 0.059 13.8 26.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) ATP-synt PF00231.19 EDN08289.1 - 4.6e-78 262.8 7.2 5.6e-78 262.5 7.2 1.0 1 0 0 1 1 1 1 ATP synthase DUF5471 PF17565.2 EDN08289.1 - 0.12 12.6 2.7 0.14 12.4 0.9 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5471) Thioredoxin PF00085.20 EDN08292.1 - 1.5e-31 108.4 0.0 4e-26 91.0 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 EDN08292.1 - 8.9e-07 28.5 0.1 3.5e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDN08292.1 - 2.1e-06 28.2 0.1 0.013 16.0 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like domain QSOX_Trx1 PF18108.1 EDN08292.1 - 0.0036 17.5 0.0 0.045 13.9 0.0 2.4 2 0 0 2 2 2 1 QSOX Trx-like domain AhpC-TSA PF00578.21 EDN08292.1 - 0.01 15.8 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 EDN08292.1 - 0.015 15.6 0.0 1.1 9.7 0.0 3.2 2 1 1 3 3 3 0 Thioredoxin-like Thioredoxin_7 PF13899.6 EDN08292.1 - 0.027 14.7 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like TraF PF13728.6 EDN08292.1 - 0.049 13.5 0.0 0.049 13.5 0.0 3.9 5 0 0 5 5 5 0 F plasmid transfer operon protein GNAT_acetyltr_2 PF13718.6 EDN08293.1 - 4e-96 320.8 0.0 7e-96 320.0 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EDN08293.1 - 1.3e-87 293.4 0.0 2.1e-87 292.7 0.0 1.3 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EDN08293.1 - 7e-65 218.2 0.0 2.5e-64 216.4 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EDN08293.1 - 1.8e-33 114.3 0.0 4.8e-33 113.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EDN08293.1 - 0.001 18.8 0.2 0.067 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN08293.1 - 0.005 17.1 0.0 0.11 12.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Acetyltransf_1 PF00583.25 EDN08293.1 - 0.03 14.5 0.0 0.16 12.2 0.0 2.3 3 0 0 3 3 3 0 Acetyltransferase (GNAT) family MARVEL PF01284.23 EDN08294.1 - 0.0013 18.8 1.4 0.0021 18.1 1.4 1.4 1 0 0 1 1 1 1 Membrane-associating domain 7tm_7 PF08395.12 EDN08294.1 - 0.0037 16.5 0.1 0.0052 16.0 0.1 1.1 1 0 0 1 1 1 1 7tm Chemosensory receptor Glyco_transf_90 PF05686.12 EDN08294.1 - 0.021 13.8 0.0 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 90 Glyco_transf_90 PF05686.12 EDN08295.1 - 0.00023 20.2 0.0 0.00094 18.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 90 GET2 PF08690.10 EDN08295.1 - 4.8 6.8 6.8 6.4 6.4 6.8 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Glyco_hydro_16 PF00722.21 EDN08296.1 - 1.5e-05 24.5 0.9 3.1e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Vps8 PF12816.7 EDN08297.1 - 2.4e-65 219.8 0.2 4.1e-65 219.0 0.2 1.4 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EDN08297.1 - 0.00015 21.7 0.0 0.0014 18.5 0.0 2.4 2 0 0 2 2 2 1 Region in Clathrin and VPS Pox_D3 PF04580.13 EDN08297.1 - 0.083 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirinae D3 protein RVT_1 PF00078.27 EDN08303.1 - 1.6e-29 103.0 0.0 2.4e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN08303.1 - 4.5e-14 52.3 0.0 1.2e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN08303.1 - 7.4e-05 22.4 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Clr2 PF10383.9 EDN08305.1 - 3.6e-36 125.1 0.0 7.2e-36 124.2 0.0 1.5 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 p450 PF00067.22 EDN08307.1 - 6.4e-24 84.5 0.0 3.3e-22 78.9 0.0 2.8 1 1 0 1 1 1 1 Cytochrome P450 ABC_membrane_2 PF06472.15 EDN08308.1 - 6.3e-78 261.9 0.0 1.8e-77 260.4 0.0 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDN08308.1 - 3.7e-15 56.7 0.0 6.7e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RuvB_N PF05496.12 EDN08308.1 - 0.02 14.6 0.0 0.24 11.1 0.0 2.4 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDN08308.1 - 0.025 14.9 0.1 0.058 13.8 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EDN08308.1 - 0.026 15.0 1.0 0.68 10.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EDN08308.1 - 0.029 14.8 0.0 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) THOC7 PF05615.13 EDN08308.1 - 0.038 14.3 0.2 0.11 12.8 0.2 1.7 1 0 0 1 1 1 0 Tho complex subunit 7 AAA_21 PF13304.6 EDN08308.1 - 0.067 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDN08308.1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EDN08308.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDN08308.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NIF PF03031.18 EDN08310.1 - 8.3e-38 129.6 0.5 1.4e-18 67.2 0.1 2.3 1 1 1 2 2 2 2 NLI interacting factor-like phosphatase Serglycin PF04360.12 EDN08310.1 - 4.4 7.2 10.4 0.39 10.6 2.0 2.8 3 1 0 3 3 3 0 Serglycin LRR_4 PF12799.7 EDN08311.1 - 2.5e-34 116.7 32.8 1.1e-07 32.0 2.7 6.3 3 1 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDN08311.1 - 1.9e-20 72.3 32.7 1.1e-07 31.5 1.8 5.9 3 2 3 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 EDN08311.1 - 6.2e-13 48.6 16.4 3e-06 26.9 1.6 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 EDN08311.1 - 5.8e-05 22.8 19.8 0.09 12.9 0.3 6.6 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 EDN08311.1 - 0.064 13.8 24.9 1.5 9.6 0.5 7.8 8 2 0 8 8 8 0 Leucine Rich Repeat Aldo_ket_red PF00248.21 EDN08312.1 - 3e-14 52.9 0.5 2.7e-13 49.8 0.5 2.4 1 1 0 1 1 1 1 Aldo/keto reductase family L27_N PF09060.10 EDN08312.1 - 0.075 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 L27_N RRM_1 PF00076.22 EDN08313.1 - 1.3e-52 175.5 1.3 1.7e-15 56.6 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN08313.1 - 2.2e-06 27.3 0.0 0.00052 19.6 0.0 3.4 3 1 1 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN08313.1 - 0.028 14.5 0.0 10 6.3 0.0 2.9 2 0 0 2 2 2 0 RNA recognition motif WW_like PF17890.1 EDN08313.1 - 0.053 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Peptidoglycan hydrolase LytB WW-like domain RRM_3 PF08777.11 EDN08313.1 - 0.056 13.5 0.5 81 3.3 0.0 3.9 4 0 0 4 4 4 0 RNA binding motif Nup35_RRM_2 PF14605.6 EDN08313.1 - 0.13 12.3 0.0 5.4 7.1 0.0 3.1 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Dynein_light PF01221.18 EDN08314.1 - 7e-40 135.2 2.5 8e-40 135.1 2.5 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ribosomal_L6e PF01159.19 EDN08314.1 - 0.015 15.8 0.6 0.018 15.5 0.6 1.1 1 0 0 1 1 1 0 Ribosomal protein L6e MFS_1 PF07690.16 EDN08317.1 - 3e-39 135.0 49.9 1.3e-37 129.5 49.9 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN08317.1 - 6.6e-08 31.8 31.4 2.8e-06 26.5 12.2 2.6 1 1 2 3 3 3 2 Sugar (and other) transporter DIOX_N PF14226.6 EDN08318.1 - 6.3e-30 104.4 0.0 7e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF4139 PF13598.6 EDN08319.1 - 2.8e-27 95.8 0.0 8.2e-27 94.3 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 EDN08319.1 - 8.3e-25 87.1 0.0 8.3e-25 87.1 0.0 3.1 3 0 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) GrpE PF01025.19 EDN08319.1 - 0.1 12.2 3.5 3.3 7.4 0.7 2.4 2 0 0 2 2 2 0 GrpE Sugarporin_N PF11471.8 EDN08319.1 - 0.12 12.4 4.6 0.25 11.3 4.6 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DUF4672 PF15716.5 EDN08319.1 - 0.28 10.8 3.7 0.63 9.6 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) Sec61_beta PF03911.16 EDN08320.1 - 2.7e-17 62.5 1.0 4.2e-17 61.9 1.0 1.3 1 0 0 1 1 1 1 Sec61beta family p450 PF00067.22 EDN08321.1 - 7.4e-10 38.2 0.0 9.9e-10 37.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 COPI_assoc PF08507.10 EDN08322.1 - 0.0021 18.1 1.8 0.0021 18.1 1.8 3.5 3 2 1 4 4 4 1 COPI associated protein Cyt_bd_oxida_II PF02322.15 EDN08322.1 - 0.65 9.3 22.9 0.17 11.2 13.2 2.1 1 1 1 2 2 2 0 Cytochrome bd terminal oxidase subunit II PCNA_N PF00705.18 EDN08325.1 - 7.7e-49 164.6 2.3 7.7e-49 164.6 2.3 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EDN08325.1 - 3.8e-48 162.9 0.0 1e-47 161.5 0.0 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EDN08325.1 - 5.1e-07 29.4 0.0 6.5e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EDN08325.1 - 0.005 16.0 0.0 0.028 13.5 0.0 1.8 1 1 1 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Vezatin PF12632.7 EDN08326.1 - 1.2e-31 110.1 2.4 5.2e-21 75.2 0.0 2.3 2 0 0 2 2 2 2 Mysoin-binding motif of peroxisomes Polysacc_synt_C PF14667.6 EDN08326.1 - 0.00023 21.2 1.1 0.0004 20.5 1.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis C-terminal domain CH PF00307.31 EDN08327.1 - 7.9e-07 29.2 0.0 0.00034 20.8 0.0 2.8 2 1 0 2 2 2 2 Calponin homology (CH) domain IQ PF00612.27 EDN08327.1 - 0.013 15.2 4.5 0.013 15.2 4.5 2.2 2 0 0 2 2 2 0 IQ calmodulin-binding motif Ribosomal_60s PF00428.19 EDN08327.1 - 0.073 13.7 5.6 0.23 12.0 5.6 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein TEX19 PF15553.6 EDN08328.1 - 0.016 15.1 0.3 0.03 14.3 0.3 1.5 1 0 0 1 1 1 0 Testis-expressed protein 19 DUF2457 PF10446.9 EDN08329.1 - 3.5e-95 319.9 52.2 3.2e-57 194.7 42.0 2.7 2 2 2 4 4 4 2 Protein of unknown function (DUF2457) BUD22 PF09073.10 EDN08329.1 - 0.00048 19.6 27.8 0.00048 19.6 27.8 1.7 2 0 0 2 2 2 1 BUD22 TFIIF_alpha PF05793.12 EDN08329.1 - 0.00075 18.2 26.2 0.0012 17.5 26.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EDN08329.1 - 0.014 13.6 33.3 0.021 13.1 33.3 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EDN08329.1 - 0.46 9.9 34.3 0.94 8.8 34.3 1.5 1 0 0 1 1 1 0 SDA1 LAP1C PF05609.12 EDN08329.1 - 1.2 8.1 15.2 1.9 7.5 15.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC27 PF09507.10 EDN08329.1 - 1.5 8.1 20.2 3.4 7.0 20.2 1.6 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Arf PF00025.21 EDN08330.1 - 1.6e-62 210.0 0.0 1.8e-62 209.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EDN08330.1 - 2.4e-08 33.6 0.1 0.0001 21.6 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EDN08330.1 - 2.8e-07 30.1 0.0 3.6e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDN08330.1 - 9.4e-07 28.9 0.0 1.2e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EDN08330.1 - 6.7e-06 26.3 0.0 1.7e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDN08330.1 - 4e-05 23.3 0.0 5.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EDN08330.1 - 0.0001 21.8 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDN08330.1 - 0.068 12.7 0.0 3.2 7.2 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Metallophos PF00149.28 EDN08331.1 - 3.2e-26 93.1 0.0 4.4e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LRR_4 PF12799.7 EDN08332.1 - 2.4e-11 43.7 5.1 0.0057 17.0 0.1 4.9 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDN08332.1 - 3.7e-11 42.6 9.1 1.3e-06 28.0 1.5 4.2 2 1 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 EDN08332.1 - 3.9e-06 26.7 8.3 7.1 7.6 0.1 7.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.6 EDN08332.1 - 4.6e-06 26.3 10.2 2.8 8.2 0.2 6.1 6 0 0 6 6 6 3 Leucine Rich repeat LRR_9 PF14580.6 EDN08332.1 - 0.018 14.6 0.1 0.96 8.9 0.3 2.5 1 1 1 2 2 2 0 Leucine-rich repeat DUF3336 PF11815.8 EDN08335.1 - 9.4e-43 145.2 1.4 1.6e-42 144.5 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDN08335.1 - 4.9e-17 62.8 0.1 8.3e-16 58.8 0.1 2.6 1 1 0 1 1 1 1 Patatin-like phospholipase GHMP_kinases_C PF08544.13 EDN08335.1 - 0.088 13.2 0.2 4.9 7.6 0.0 3.0 3 1 1 4 4 4 0 GHMP kinases C terminal DUF4202 PF13875.6 EDN08335.1 - 0.11 12.4 0.7 0.19 11.6 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4202) DUF4404 PF14357.6 EDN08335.1 - 0.39 11.4 2.2 1.9 9.2 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) TPR_19 PF14559.6 EDN08336.1 - 1.2e-21 77.0 11.0 6.8e-08 32.9 0.1 6.3 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDN08336.1 - 1.4e-13 50.2 6.2 0.011 16.0 0.0 7.4 9 0 0 9 9 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDN08336.1 - 8.4e-11 41.4 12.4 0.051 13.3 0.0 6.4 5 2 2 7 7 7 4 TPR repeat TPR_14 PF13428.6 EDN08336.1 - 9.2e-11 41.6 9.7 0.0012 19.5 0.1 7.4 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN08336.1 - 1.5e-08 34.1 16.8 0.22 11.7 0.2 8.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_20 PF14561.6 EDN08336.1 - 1.3e-05 25.4 3.0 3.1 8.2 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN08336.1 - 1.4e-05 25.3 16.6 0.032 14.5 0.3 5.0 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EDN08336.1 - 3.6e-05 23.5 5.2 5.5 7.3 0.3 6.1 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN08336.1 - 5.4e-05 23.7 13.6 0.025 15.2 0.3 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDN08336.1 - 8.2e-05 22.7 1.7 0.0018 18.4 0.1 3.6 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN08336.1 - 0.00045 20.2 20.8 3.2 8.2 0.1 9.3 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDN08336.1 - 0.00086 18.6 4.9 1.4 8.1 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDN08336.1 - 0.0029 18.1 4.8 0.26 11.7 0.3 3.4 3 0 0 3 3 3 1 Alkyl sulfatase dimerisation TPR_4 PF07721.14 EDN08336.1 - 0.02 15.5 2.0 31 5.6 0.1 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EDN08336.1 - 0.05 13.0 1.0 55 3.0 0.1 3.9 3 1 0 4 4 4 0 MalT-like TPR region ChAPs PF09295.10 EDN08336.1 - 0.091 11.8 0.2 0.28 10.1 0.0 1.9 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 EDN08336.1 - 0.1 13.0 0.4 0.76 10.2 0.2 2.6 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_1 PF00515.28 EDN08336.1 - 0.19 11.6 20.3 9.7 6.2 0.1 8.3 8 1 0 8 8 8 0 Tetratricopeptide repeat SNAP PF14938.6 EDN08336.1 - 0.65 9.4 3.7 15 4.9 0.0 3.6 4 0 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EDN08336.1 - 0.66 10.3 23.2 9.3 6.6 0.2 7.2 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN08336.1 - 0.86 10.4 12.3 5.6 7.8 0.0 5.8 6 0 0 6 6 4 0 Tetratricopeptide repeat O-FucT PF10250.9 EDN08337.1 - 0.035 13.8 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase SAM_2 PF07647.17 EDN08338.1 - 3.2e-08 33.6 0.2 6.7e-08 32.5 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDN08338.1 - 0.0023 18.3 0.2 0.0048 17.3 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 EDN08338.1 - 0.045 14.0 0.4 0.11 12.8 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) bZIP_C PF12498.8 EDN08338.1 - 2.3 9.2 8.5 5.6 8.0 1.6 3.4 2 1 1 3 3 3 0 Basic leucine-zipper C terminal Rab5ip PF07019.12 EDN08339.1 - 7e-24 84.2 9.8 2.3e-23 82.6 9.8 1.7 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) MFS_1 PF07690.16 EDN08340.1 - 4.9e-18 65.2 45.0 4.9e-18 65.2 45.0 3.5 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDN08340.1 - 1.6e-08 33.4 13.6 2.5e-06 26.2 2.4 2.2 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sulfate_transp PF00916.20 EDN08341.1 - 3.4e-100 335.5 18.4 5e-100 334.9 18.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDN08341.1 - 1.7e-07 30.9 0.0 3.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EDN08341.1 - 0.0025 18.2 2.0 0.0025 18.2 2.0 3.0 2 1 1 3 3 3 1 Molybdate transporter of MFS superfamily SNN_transmemb PF09049.10 EDN08341.1 - 7.8 6.5 9.1 0.21 11.5 1.5 2.4 2 0 0 2 2 2 0 Stannin transmembrane DnaJ_C PF01556.18 EDN08343.1 - 6.4e-08 32.8 0.0 9.1e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain URO-D PF01208.17 EDN08344.1 - 1.5e-25 90.1 0.0 1.6e-25 90.0 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) URO-D PF01208.17 EDN08345.1 - 2.1e-06 27.2 0.1 3.3e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ribosomal_L10 PF00466.20 EDN08346.1 - 2.1e-23 82.3 0.3 1.6e-22 79.5 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EDN08346.1 - 5.8e-22 77.5 0.0 1.1e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EDN08346.1 - 3.4e-14 53.2 7.3 3.4e-14 53.2 7.3 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein Vps53_N PF04100.12 EDN08347.1 - 6.6e-107 357.8 4.3 1.3e-106 356.8 4.3 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal TAP_C PF03943.13 EDN08347.1 - 9.8e-12 44.3 0.9 2.9e-11 42.8 0.9 1.9 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.20 EDN08347.1 - 4.5e-08 33.7 0.0 3e-07 31.0 0.0 2.5 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain Vps54_N PF10475.9 EDN08347.1 - 4.2e-07 29.5 8.0 4.2e-07 29.5 8.0 2.3 2 1 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex LRR_4 PF12799.7 EDN08347.1 - 2.2e-06 27.9 1.1 1e-05 25.8 1.1 2.3 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EDN08347.1 - 2.6e-05 23.8 1.5 3.5e-05 23.4 0.2 1.8 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 EDN08347.1 - 0.00087 19.0 1.7 0.003 17.3 1.7 2.0 1 0 0 1 1 1 1 Leucine rich repeat RRM_9 PF18444.1 EDN08347.1 - 0.0014 18.4 0.0 0.0078 16.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif COG2 PF06148.11 EDN08347.1 - 0.0021 18.1 5.2 0.011 15.8 5.3 2.1 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Cornifin PF02389.15 EDN08347.1 - 0.025 14.7 2.6 0.057 13.6 2.6 1.5 1 0 0 1 1 1 0 Cornifin (SPRR) family APG6_N PF17675.1 EDN08347.1 - 0.097 13.2 7.8 0.36 11.4 7.8 2.0 1 0 0 1 1 1 0 Apg6 coiled-coil region LRR_1 PF00560.33 EDN08347.1 - 0.1 13.2 0.2 52 5.0 0.1 3.5 3 0 0 3 3 2 0 Leucine Rich Repeat Sigma70_ner PF04546.13 EDN08347.1 - 0.23 11.3 6.0 0.69 9.8 6.0 1.8 1 1 0 1 1 1 0 Sigma-70, non-essential region DUF5339 PF17274.2 EDN08347.1 - 0.32 11.9 6.6 1.6 9.6 0.4 3.1 1 1 1 2 2 2 0 Family of unknown function (DUF5339) Zw10 PF06248.13 EDN08347.1 - 0.54 8.8 13.0 0.034 12.7 6.9 2.0 3 0 0 3 3 3 0 Centromere/kinetochore Zw10 FapA PF03961.13 EDN08347.1 - 0.69 8.4 3.0 2 6.9 3.0 1.7 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pox_F11 PF04943.12 EDN08347.1 - 0.71 8.9 6.1 1.3 8.0 6.1 1.3 1 0 0 1 1 1 0 Poxvirus F11 protein DUF1515 PF07439.11 EDN08347.1 - 1.7 8.7 3.6 1.6 8.8 1.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) YabA PF06156.13 EDN08347.1 - 2.8 8.6 4.5 4.1 8.1 2.5 2.4 2 0 0 2 2 2 0 Initiation control protein YabA COPIIcoated_ERV PF07970.12 EDN08348.1 - 1.6e-84 283.2 0.0 2.1e-84 282.8 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDN08348.1 - 3e-29 101.2 0.0 2.8e-28 98.1 0.0 2.2 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) HalOD1 PF18545.1 EDN08350.1 - 0.14 12.4 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Halobacterial output domain 1 PH PF00169.29 EDN08351.1 - 1.3e-08 35.2 0.1 2.4e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EDN08351.1 - 0.00012 22.4 0.0 0.00026 21.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain zf-C2H2 PF00096.26 EDN08353.1 - 1.4e-24 85.2 59.6 7.5e-05 23.0 1.1 10.7 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN08353.1 - 3.2e-18 64.8 56.5 0.019 15.8 0.6 10.8 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDN08353.1 - 3.5e-12 46.2 54.8 0.00067 20.0 0.6 10.8 11 0 0 11 11 11 6 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDN08353.1 - 1e-07 32.1 9.7 0.27 11.6 0.0 8.3 8 0 0 8 8 8 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EDN08353.1 - 2.1e-07 30.5 6.0 0.15 11.9 0.1 5.0 4 0 0 4 4 4 3 zinc-finger C2H2-type GAGA PF09237.11 EDN08353.1 - 5.7e-05 22.8 0.2 5.7e-05 22.8 0.2 3.4 4 0 0 4 4 4 1 GAGA factor FOXP-CC PF16159.5 EDN08353.1 - 0.00024 21.7 32.9 0.55 10.9 0.1 8.8 7 2 3 10 10 10 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EDN08353.1 - 0.0025 18.1 20.8 0.039 14.3 1.8 4.8 3 1 2 5 5 5 3 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 EDN08353.1 - 0.025 14.3 1.3 0.025 14.3 1.3 8.9 9 0 0 9 9 9 0 C2H2-type zinc-finger domain zf-met PF12874.7 EDN08353.1 - 0.044 14.2 13.8 0.44 11.0 0.1 6.9 8 0 0 8 8 7 0 Zinc-finger of C2H2 type zf_Hakai PF18408.1 EDN08353.1 - 0.069 12.9 28.3 0.15 11.8 1.5 7.1 6 1 1 7 7 7 0 C2H2 Hakai zinc finger domain Ogr_Delta PF04606.12 EDN08353.1 - 0.18 11.8 0.2 0.18 11.8 0.2 4.9 4 2 1 5 5 4 0 Ogr/Delta-like zinc finger DUF5472 PF17566.2 EDN08353.1 - 2.9 7.9 4.4 30 4.7 0.2 3.8 3 1 1 4 4 4 0 Family of unknown function (DUF5472) zf-C2H2_9 PF16293.5 EDN08353.1 - 7.8 6.4 8.8 12 5.9 0.3 4.0 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) RNA_pol_Rpb6 PF01192.22 EDN08354.1 - 1.5e-07 31.2 1.3 2.5e-06 27.3 1.3 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb6 RVT_2 PF07727.14 EDN08356.1 - 7.9e-37 127.2 0.0 1.1e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DEAD PF00270.29 EDN08358.1 - 1.5e-09 37.9 0.0 2.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN08358.1 - 5e-05 23.4 0.0 6.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN08358.1 - 0.024 14.9 0.2 0.097 12.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain Ribosomal_S4e PF00900.20 EDN08359.1 - 0.21 11.5 0.2 29 4.7 0.0 2.6 2 0 0 2 2 2 0 Ribosomal family S4e Pkinase_fungal PF17667.1 EDN08361.1 - 6.6e-19 68.0 0.1 7.9e-19 67.7 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase zf-CSL PF05207.13 EDN08363.1 - 0.016 14.9 0.2 0.018 14.8 0.2 1.2 1 0 0 1 1 1 0 CSL zinc finger DUF573 PF04504.14 EDN08365.1 - 1.2e-05 25.8 0.1 3.4e-05 24.4 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN08365.1 - 0.00012 22.2 0.1 0.00026 21.1 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08365.1 - 0.013 15.8 0.2 0.033 14.4 0.2 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN08365.1 - 0.05 14.0 2.3 0.48 10.8 2.3 2.3 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain APG5 PF04106.12 EDN08366.1 - 0.11 12.1 0.2 0.24 10.9 0.1 1.5 2 0 0 2 2 2 0 Autophagy protein Apg5 Helicase_C PF00271.31 EDN08367.1 - 2.7e-15 56.7 0.1 6.9e-15 55.4 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN08367.1 - 4.1e-14 52.7 0.0 2.3e-13 50.3 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN08367.1 - 1.2e-07 31.9 0.0 8.6e-07 29.1 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EDN08367.1 - 0.026 13.3 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain ATPase PF06745.13 EDN08367.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 KaiC RVT_1 PF00078.27 EDN08368.1 - 8.1e-23 81.1 0.0 3.5e-15 56.1 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN08368.1 - 2.8e-14 53.0 0.0 8.8e-14 51.4 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN08368.1 - 2.6e-05 23.8 0.2 0.0001 21.9 0.2 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF573 PF04504.14 EDN08369.1 - 9.2e-06 26.2 0.1 2.5e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN08369.1 - 9e-05 22.6 0.1 0.0002 21.5 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08369.1 - 0.0084 16.3 0.1 0.025 14.8 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN08369.1 - 0.033 14.6 2.3 0.37 11.2 2.3 2.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain OrsD PF12013.8 EDN08371.1 - 3e-19 69.5 1.0 1.1e-18 67.7 0.1 2.2 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D Retrotran_gag_3 PF14244.6 EDN08372.1 - 0.014 15.2 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN08372.1 - 0.045 13.4 0.1 0.076 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) zf-C2H2_10 PF16588.5 EDN08373.1 - 0.0079 15.9 3.0 0.014 15.1 3.0 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger Retrotran_gag_3 PF14244.6 EDN08373.1 - 0.032 14.0 0.1 0.07 12.9 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN08373.1 - 0.093 12.4 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Phage_min_cap2 PF06152.11 EDN08373.1 - 0.14 11.0 1.5 0.24 10.3 1.5 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 PCSK9_C2 PF18464.1 EDN08375.1 - 2.3 8.3 8.1 6 7.0 0.5 2.9 1 1 2 4 4 4 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain Herpes_TK_C PF08465.10 EDN08377.1 - 0.12 12.2 0.2 0.31 10.8 0.2 1.8 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal Nexin_C PF08628.12 EDN08378.1 - 0.0062 17.1 0.3 0.0079 16.8 0.3 1.1 1 0 0 1 1 1 1 Sorting nexin C terminal RVT_1 PF00078.27 EDN08379.1 - 2.6e-25 89.3 0.0 4.5e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN08379.1 - 3.7e-12 46.1 0.0 1.1e-11 44.6 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN08379.1 - 1.8e-10 41.1 0.1 1.8e-09 37.9 0.1 2.3 1 1 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN08379.1 - 0.029 14.8 1.0 0.21 12.0 0.5 2.5 2 0 0 2 2 2 0 ORF 12 gene product N-terminal SCAN PF02023.17 EDN08380.1 - 0.09 12.6 1.7 0.22 11.4 1.7 1.6 1 0 0 1 1 1 0 SCAN domain Methyltr_RsmB-F PF01189.17 EDN08381.1 - 2.2e-73 246.2 0.0 4.8e-73 245.1 0.0 1.6 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F RVT_2 PF07727.14 EDN08381.1 - 3e-43 148.2 0.0 4.4e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN08381.1 - 6.7e-12 45.7 0.0 1.8e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Methyltr_RsmF_N PF17125.5 EDN08381.1 - 4.5e-07 30.3 0.0 1.1e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF zf-CCHC PF00098.23 EDN08381.1 - 0.00049 20.0 2.5 0.001 19.0 2.5 1.5 1 0 0 1 1 1 1 Zinc knuckle FtsJ PF01728.19 EDN08381.1 - 0.0021 18.2 0.0 0.0047 17.1 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase gag_pre-integrs PF13976.6 EDN08381.1 - 0.0026 17.6 0.0 0.0087 15.9 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain U3_snoRNA_assoc PF08297.11 EDN08381.1 - 0.65 10.8 6.8 3 8.6 6.8 2.2 1 0 0 1 1 1 0 U3 snoRNA associated APH PF01636.23 EDN08382.1 - 1.6e-19 70.8 0.0 2.1e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN08382.1 - 3.5e-05 23.5 0.0 6.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EDN08383.1 - 2.4e-05 23.8 0.0 4.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDN08383.1 - 3.1e-05 23.5 0.0 5.4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EDN08383.1 - 0.0012 17.7 1.6 0.0027 16.5 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase CENP-Q PF13094.6 EDN08383.1 - 0.0057 16.9 6.3 0.012 15.8 6.3 1.6 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit APH PF01636.23 EDN08383.1 - 0.0066 16.4 0.1 0.0066 16.4 0.1 2.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDN08383.1 - 0.13 11.8 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 RIO1 family ORC_WH_C PF18137.1 EDN08383.1 - 0.51 10.4 10.1 0.19 11.8 6.5 2.0 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF4407 PF14362.6 EDN08383.1 - 1.1 8.5 5.6 2.4 7.4 5.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Caldesmon PF02029.15 EDN08383.1 - 1.2 7.8 20.6 2.8 6.6 20.6 1.5 1 0 0 1 1 1 0 Caldesmon FemAB PF02388.16 EDN08383.1 - 4.5 6.0 5.1 8.7 5.1 5.1 1.4 1 0 0 1 1 1 0 FemAB family Myb_DNA-binding PF00249.31 EDN08385.1 - 0.053 13.7 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain FA_hydroxylase PF04116.13 EDN08386.1 - 1.2e-16 61.3 18.1 1.2e-16 61.3 18.1 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Unpaired PF15972.5 EDN08387.1 - 0.046 13.2 0.0 0.046 13.2 0.0 1.0 1 0 0 1 1 1 0 Unpaired protein MORN PF02493.20 EDN08388.1 - 3.1e-14 51.9 21.2 9.5e-06 25.2 0.1 4.6 4 0 0 4 4 4 4 MORN repeat UCH PF00443.29 EDN08388.1 - 1.3e-12 47.8 0.0 2.2e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_3 PF13920.6 EDN08388.1 - 1.4e-10 40.8 11.6 2.3e-10 40.2 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDN08388.1 - 0.00025 20.8 11.0 0.00043 20.1 11.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDN08388.1 - 0.14 12.1 12.6 0.25 11.3 12.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain USP7_ICP0_bdg PF12436.8 EDN08388.1 - 0.15 11.4 0.0 0.5 9.6 0.0 1.8 2 0 0 2 2 2 0 ICP0-binding domain of Ubiquitin-specific protease 7 Striatin PF08232.12 EDN08389.1 - 1.3e-47 162.3 4.7 1.3e-47 162.3 4.7 2.0 2 0 0 2 2 2 1 Striatin family WD40 PF00400.32 EDN08389.1 - 1.1e-26 92.5 21.0 3.7e-05 24.4 0.4 8.7 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN08389.1 - 2.5e-05 24.5 0.3 0.11 12.8 0.0 4.5 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain CALCOCO1 PF07888.11 EDN08389.1 - 0.0027 16.7 8.1 0.0048 15.8 8.1 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like eIF2A PF08662.11 EDN08389.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ERM PF00769.19 EDN08389.1 - 1.1 9.1 13.2 0.064 13.1 7.4 1.7 2 0 0 2 2 2 0 Ezrin/radixin/moesin family XPA_C PF05181.12 EDN08390.1 - 4.9e-14 52.0 8.1 1.3e-12 47.5 8.1 2.5 1 1 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 EDN08390.1 - 0.0022 18.0 3.0 0.0022 18.0 3.0 1.7 2 0 0 2 2 2 1 XPA protein N-terminal YhfH PF14149.6 EDN08390.1 - 0.011 15.6 0.7 3.5 7.7 0.0 2.7 2 0 0 2 2 2 0 YhfH-like protein zf-AD PF07776.15 EDN08390.1 - 0.25 11.6 2.6 0.25 11.6 0.9 1.9 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) PIG-P PF08510.12 EDN08391.1 - 5.5e-51 171.6 2.6 5.5e-51 171.6 2.6 1.7 2 0 0 2 2 2 1 PIG-P DPM2 PF07297.12 EDN08391.1 - 0.066 13.5 9.3 0.11 12.8 9.3 1.2 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Myb_DNA-binding PF00249.31 EDN08393.1 - 1.6e-12 47.4 0.0 1.6e-07 31.4 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08393.1 - 0.014 15.6 1.0 1.1 9.6 0.1 3.2 3 0 0 3 3 3 0 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EDN08393.1 - 0.027 14.4 0.1 0.089 12.7 0.1 1.9 1 0 0 1 1 1 0 Myb DNA-binding like UvrD_C PF13361.6 EDN08393.1 - 0.088 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DS PF01916.17 EDN08394.1 - 1.5e-71 241.0 0.1 1.9e-70 237.4 0.1 1.9 1 1 0 1 1 1 1 Deoxyhypusine synthase MINDY_DUB PF04424.13 EDN08395.1 - 1.1e-16 60.9 0.0 2.2e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase Gcd10p PF04189.13 EDN08396.1 - 8.5e-121 402.7 0.0 1.3e-120 402.0 0.0 1.3 1 0 0 1 1 1 1 Gcd10p family CBP PF12192.8 EDN08397.1 - 3.9e-07 30.2 0.1 8.5e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 Fungal calcium binding protein MIT PF04212.18 EDN08397.1 - 0.04 14.0 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain RNase_H PF00075.24 EDN08398.1 - 1.5e-12 47.9 0.0 4.6e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 RNase H Nexin_C PF08628.12 EDN08399.1 - 0.0095 16.5 0.3 0.014 16.0 0.3 1.2 1 0 0 1 1 1 1 Sorting nexin C terminal DUF2273 PF10031.9 EDN08401.1 - 1.6 8.8 6.5 0.77 9.8 3.2 2.3 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) P21-Arc PF04062.14 EDN08402.1 - 1.5e-73 246.5 0.0 1.7e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit AAA PF00004.29 EDN08403.1 - 2.5e-14 53.8 0.0 6.8e-14 52.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EDN08403.1 - 2.5e-13 50.2 0.0 7.2e-13 48.8 0.0 1.8 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EDN08403.1 - 1.8e-10 40.8 1.3 1.2e-08 34.9 0.0 2.8 2 1 1 3 3 3 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EDN08403.1 - 1.9e-07 31.3 0.0 4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 EDN08403.1 - 6e-06 26.2 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_11 PF13086.6 EDN08403.1 - 9e-06 25.7 0.3 0.00047 20.0 0.0 2.2 1 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN08403.1 - 3.9e-05 23.9 0.1 0.051 13.8 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.11 EDN08403.1 - 0.00022 21.1 0.0 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN08403.1 - 0.00023 21.6 0.1 0.004 17.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDN08403.1 - 0.00029 20.9 0.1 0.0012 18.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EDN08403.1 - 0.00049 19.9 0.2 0.003 17.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain DEAD PF00270.29 EDN08403.1 - 0.00053 19.8 0.8 0.0027 17.5 0.1 2.3 2 2 1 3 3 3 1 DEAD/DEAH box helicase AAA_14 PF13173.6 EDN08403.1 - 0.00094 19.2 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDN08403.1 - 0.0017 18.2 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN08403.1 - 0.0023 18.3 0.2 0.06 13.7 0.1 2.5 1 1 1 2 2 2 1 AAA domain ResIII PF04851.15 EDN08403.1 - 0.0059 16.6 0.0 1.5 8.8 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Rad17 PF03215.15 EDN08403.1 - 0.007 16.3 0.0 0.03 14.3 0.0 1.9 1 1 0 2 2 2 1 Rad17 P-loop domain AAA_25 PF13481.6 EDN08403.1 - 0.008 15.8 0.0 0.048 13.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EDN08403.1 - 0.0082 15.6 0.0 2 7.8 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein RuvB_N PF05496.12 EDN08403.1 - 0.0082 15.9 0.0 0.028 14.2 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN08403.1 - 0.0085 16.6 0.0 0.018 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDN08403.1 - 0.013 15.1 0.0 0.034 13.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EDN08403.1 - 0.019 14.7 0.0 0.063 13.0 0.0 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EDN08403.1 - 0.024 14.9 0.0 0.05 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EDN08403.1 - 0.038 13.4 0.2 0.4 10.0 0.0 2.4 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI TniB PF05621.11 EDN08403.1 - 0.097 12.1 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein RNA_helicase PF00910.22 EDN08403.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.13 EDN08403.1 - 0.18 10.9 0.0 0.33 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) His_Phos_2 PF00328.22 EDN08404.1 - 5.7e-06 25.9 0.0 0.00043 19.8 0.0 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Pro_isomerase PF00160.21 EDN08405.1 - 1.2e-37 129.6 0.0 2.6e-37 128.5 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rubredoxin_2 PF18073.1 EDN08405.1 - 0.55 10.0 2.0 0.99 9.2 2.0 1.4 1 0 0 1 1 1 0 Rubredoxin metal binding domain R3H PF01424.22 EDN08406.1 - 3.1e-11 43.1 0.1 6.9e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EDN08406.1 - 6.9e-06 25.8 0.1 1.3e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldo_ket_red PF00248.21 EDN08407.1 - 2.3e-18 66.4 0.0 3.7e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family HSF_DNA-bind PF00447.17 EDN08408.1 - 3e-14 53.4 0.2 1.7e-11 44.5 0.2 2.6 1 1 1 2 2 2 2 HSF-type DNA-binding TMF_DNA_bd PF12329.8 EDN08408.1 - 0.18 11.9 2.9 0.59 10.2 0.5 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Arb2 PF09757.9 EDN08409.1 - 3.3e-61 206.7 0.4 4.1e-61 206.4 0.4 1.0 1 0 0 1 1 1 1 Arb2 domain Luciferase_cat PF10285.9 EDN08409.1 - 0.18 11.1 0.1 0.26 10.6 0.1 1.2 1 0 0 1 1 1 0 Luciferase catalytic domain Hist_deacetyl PF00850.19 EDN08410.1 - 2.9e-28 99.2 0.0 3.6e-28 98.9 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain B-block_TFIIIC PF04182.12 EDN08410.1 - 0.063 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Gp_dh_C PF02800.20 EDN08411.1 - 8e-71 236.7 0.0 1.1e-70 236.2 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EDN08411.1 - 4e-39 133.0 0.3 1e-38 131.7 0.2 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EDN08411.1 - 0.057 13.6 0.7 0.23 11.6 0.0 2.2 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 EDN08411.1 - 0.086 12.2 0.2 0.22 10.9 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pho88 PF10032.9 EDN08412.1 - 1.1e-55 187.7 0.8 1.4e-55 187.4 0.0 1.5 2 0 0 2 2 2 1 Phosphate transport (Pho88) DUF4512 PF14975.6 EDN08412.1 - 0.014 16.2 0.2 0.057 14.2 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4512) Histone PF00125.24 EDN08415.1 - 1.2e-16 61.3 0.0 1.7e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EDN08415.1 - 1e-11 44.3 0.0 2.4e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EDN08415.1 - 1.7e-06 28.2 0.0 2.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Sugar_tr PF00083.24 EDN08417.1 - 1.1e-121 406.9 24.8 1.3e-121 406.7 24.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN08417.1 - 2.1e-20 72.9 45.3 3.3e-11 42.7 23.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EDN08418.1 - 4.2e-36 124.6 35.9 4.2e-36 124.6 35.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-ZPR1 PF03367.13 EDN08419.1 - 4.4e-106 351.6 0.2 8.1e-53 178.5 0.0 2.4 3 0 0 3 3 3 2 ZPR1 zinc-finger domain zf-RRPl_C4 PF17026.5 EDN08419.1 - 0.039 14.1 5.1 0.16 12.1 1.2 2.3 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zinc-ribbons_6 PF07191.12 EDN08419.1 - 0.07 13.1 3.9 0.97 9.5 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbons Ima1_N PF09779.9 EDN08419.1 - 0.74 10.7 3.4 3.9 8.3 0.0 2.9 3 0 0 3 3 3 0 Ima1 N-terminal domain Pro_isomerase PF00160.21 EDN08420.1 - 1.2e-36 126.4 0.0 1.9e-36 125.8 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Arrestin_C PF02752.22 EDN08421.1 - 1.2e-14 54.9 0.0 4.9e-14 52.9 0.0 2.0 2 1 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain tRNA_int_end_N2 PF12928.7 EDN08423.1 - 1.5e-31 108.3 0.0 2.8e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EDN08423.1 - 0.006 16.2 0.0 0.015 14.9 0.0 1.6 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Skp1_POZ PF03931.15 EDN08424.1 - 9.4e-09 35.3 0.0 1.2e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain adh_short PF00106.25 EDN08425.1 - 1.8e-31 109.1 2.4 4e-20 72.1 2.2 2.9 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN08425.1 - 8.8e-29 100.7 4.3 2.1e-22 79.9 4.0 2.9 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN08425.1 - 1.4e-06 28.4 4.1 1.1e-05 25.4 0.2 3.3 2 2 1 3 3 3 1 KR domain Epimerase PF01370.21 EDN08425.1 - 0.00084 18.9 0.6 0.062 12.7 0.6 2.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EDN08425.1 - 0.0012 18.1 0.0 0.015 14.5 0.0 2.1 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 EDN08425.1 - 0.029 14.9 0.0 0.078 13.6 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EDN08425.1 - 0.075 12.4 0.0 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ThiF PF00899.21 EDN08426.1 - 1.5e-61 207.9 0.0 2.4e-61 207.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EDN08426.1 - 8.8e-23 80.7 0.7 2.6e-22 79.2 0.7 1.9 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EDN08426.1 - 1.5e-05 25.1 1.4 0.00026 21.0 0.0 2.3 1 1 1 2 2 2 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EDN08426.1 - 0.0023 18.4 0.0 0.006 17.0 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EDN08426.1 - 0.022 14.8 0.0 0.079 13.0 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EDN08426.1 - 0.16 12.5 0.3 5.6 7.6 0.1 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Q_salvage PF10343.9 EDN08427.1 - 5.7e-132 439.5 0.0 9.5e-132 438.8 0.0 1.4 1 1 0 1 1 1 1 Potential Queuosine, Q, salvage protein family Amidase PF01425.21 EDN08428.1 - 5.2e-91 305.9 0.0 7e-91 305.4 0.0 1.2 1 0 0 1 1 1 1 Amidase NAPRTase PF04095.16 EDN08428.1 - 0.18 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) family DNA_pol_delta_4 PF04081.13 EDN08429.1 - 2.1e-37 128.4 1.6 3.3e-37 127.8 1.6 1.3 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 CFEM PF05730.11 EDN08430.1 - 2.5e-15 56.3 10.5 3.4e-15 55.9 10.5 1.2 1 0 0 1 1 1 1 CFEM domain Citrate_bind PF16114.5 EDN08434.1 - 1.7e-87 291.5 0.1 2.4e-87 291.0 0.1 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EDN08434.1 - 1.8e-08 34.2 0.0 2.8e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Reovirus_M2 PF05993.12 EDN08434.1 - 0.058 11.5 0.1 0.085 11.0 0.1 1.1 1 0 0 1 1 1 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) Citrate_synt PF00285.21 EDN08435.1 - 2.4e-20 72.9 0.0 3.7e-17 62.5 0.0 2.7 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 EDN08435.1 - 3.3e-19 69.4 0.2 1.3e-18 67.5 0.0 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EDN08435.1 - 1.3e-14 54.3 0.1 2.3e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EDN08435.1 - 7.7e-07 29.0 0.0 1.6e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain RNase_P_Rpp14 PF01900.19 EDN08436.1 - 2.5e-11 43.7 0.0 4e-11 43.1 0.0 1.3 1 1 0 1 1 1 1 Rpp14/Pop5 family DUF2407 PF10302.9 EDN08436.1 - 0.15 12.6 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain ATP_bind_1 PF03029.17 EDN08437.1 - 3.7e-77 259.4 0.0 4.4e-77 259.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EDN08437.1 - 0.00094 18.2 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 EDN08437.1 - 0.004 17.1 0.0 2.6 7.9 0.0 2.3 1 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDN08437.1 - 0.0062 16.3 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_10 PF12846.7 EDN08437.1 - 0.0089 15.0 0.0 0.014 14.3 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain MMR_HSR1 PF01926.23 EDN08437.1 - 0.036 14.1 0.0 0.36 10.9 0.0 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EDN08437.1 - 0.042 14.0 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 EDN08437.1 - 0.054 12.9 0.0 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Fer4_NifH PF00142.18 EDN08437.1 - 0.11 11.9 0.1 0.35 10.3 0.0 1.7 1 1 1 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 EDN08437.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EDN08437.1 - 0.16 12.3 0.0 0.31 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EDN08437.1 - 0.25 11.8 1.3 0.32 11.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 EDN08438.1 - 1.3e-05 25.9 0.0 0.071 14.0 0.0 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 EDN08439.1 - 1.4e-05 25.8 0.0 0.023 15.6 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat Rib_5-P_isom_A PF06026.14 EDN08440.1 - 3.6e-43 147.1 0.0 6.7e-43 146.3 0.0 1.4 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EDN08440.1 - 0.083 12.8 0.0 6.8 6.6 0.0 2.1 2 0 0 2 2 2 0 DeoR C terminal sensor domain ThiF PF00899.21 EDN08441.1 - 8.7e-18 64.6 0.0 5.6e-17 61.9 0.0 2.1 1 1 0 1 1 1 1 ThiF family DUF2325 PF10087.9 EDN08441.1 - 0.08 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) Cpn10 PF00166.21 EDN08444.1 - 7e-21 74.1 0.0 7.7e-21 74.0 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit DUF3435 PF11917.8 EDN08446.1 - 1.2e-55 189.1 0.1 4.9e-46 157.5 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) Phage_int_SAM_4 PF13495.6 EDN08446.1 - 0.037 14.5 0.4 0.38 11.3 0.4 2.4 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain DDE_1 PF03184.19 EDN08447.1 - 3.2e-29 101.8 0.0 1.2e-28 99.9 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN08447.1 - 0.0083 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EDN08447.1 - 0.051 13.3 11.4 0.036 13.8 3.0 2.4 2 0 0 2 2 2 0 C2H2 zinc-finger Retrotran_gag_3 PF14244.6 EDN08447.1 - 0.068 13.0 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF489 PF04356.12 EDN08448.1 - 0.0092 16.0 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF489) Fip1 PF05182.13 EDN08450.1 - 6.8e-21 73.5 2.4 1.2e-20 72.8 2.4 1.4 1 0 0 1 1 1 1 Fip1 motif WRNPLPNID PF15017.6 EDN08450.1 - 0.61 11.0 8.1 1.4 9.8 8.1 1.6 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box TFIIE-A_C PF11521.8 EDN08450.1 - 2.7 8.3 12.6 0.24 11.7 7.2 2.0 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Ribosomal_60s PF00428.19 EDN08450.1 - 6.4 7.4 12.5 2.5 8.8 9.2 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein XAP5 PF04921.14 EDN08451.1 - 3.1e-66 223.7 0.0 8.8e-64 215.7 0.0 2.3 1 1 0 1 1 1 1 XAP5, circadian clock regulator DUF4604 PF15377.6 EDN08451.1 - 0.031 14.7 4.6 0.053 14.0 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Dict-STAT-coil PF09267.10 EDN08452.1 - 0.0031 17.9 0.6 0.0055 17.1 0.6 1.3 1 0 0 1 1 1 1 Dictyostelium STAT, coiled coil DUF1031 PF06275.11 EDN08452.1 - 0.032 14.5 0.3 0.066 13.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1031) DUF4767 PF15983.5 EDN08452.1 - 0.033 14.5 0.1 0.046 14.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4767) Nucleoporin_FG PF13634.6 EDN08453.1 - 2.2e-12 47.7 45.9 9.4e-08 32.8 20.2 3.4 1 1 3 4 4 4 4 Nucleoporin FG repeat region DUF1664 PF07889.12 EDN08453.1 - 0.036 14.1 0.2 2.6 8.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Pectate_lyase_3 PF12708.7 EDN08454.1 - 2.9e-25 89.4 12.0 9.8e-10 38.6 0.5 4.1 3 1 1 4 4 4 3 Pectate lyase superfamily protein WD40 PF00400.32 EDN08455.1 - 0.00017 22.3 2.4 5 8.2 0.3 5.7 5 1 0 5 5 5 1 WD domain, G-beta repeat Lactonase PF10282.9 EDN08455.1 - 0.021 14.1 0.0 0.081 12.2 0.0 1.9 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller TPR_1 PF00515.28 EDN08457.1 - 2.3e-06 27.2 0.8 0.046 13.6 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDN08457.1 - 5.7e-05 22.9 1.3 0.21 11.8 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDN08457.1 - 0.00021 21.5 0.2 0.00059 20.1 0.2 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDN08457.1 - 0.00089 19.1 0.3 0.75 10.0 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDN08457.1 - 0.0011 18.6 0.0 0.0028 17.3 0.0 1.7 1 0 0 1 1 1 1 TPR repeat Phage_GP20 PF06810.11 EDN08457.1 - 0.022 14.6 3.3 0.055 13.3 3.3 1.7 1 0 0 1 1 1 0 Phage minor structural protein GP20 TLP1_add_C PF18313.1 EDN08457.1 - 0.12 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Thiolase-like protein type 1 additional C-terminal domain DUF4407 PF14362.6 EDN08457.1 - 0.12 11.7 4.9 0.17 11.2 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_14 PF13428.6 EDN08457.1 - 0.29 12.1 3.6 3.1 8.9 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN08457.1 - 0.39 11.5 2.1 74 4.3 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HAD_2 PF13419.6 EDN08458.1 - 4.7e-17 62.6 0.0 9.9e-17 61.6 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN08458.1 - 1.3e-09 38.7 0.0 1.4e-07 32.1 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN08458.1 - 2.8e-05 24.1 0.0 5.8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Abhydrolase_3 PF07859.13 EDN08459.1 - 2.8e-33 115.5 0.0 4e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EDN08459.1 - 0.00055 18.9 0.0 0.0013 17.7 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family rve PF00665.26 EDN08461.1 - 1.6e-15 57.4 0.0 4.6e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN08461.1 - 5.9e-14 51.7 1.5 1.4e-13 50.5 1.5 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RT_RNaseH PF17917.1 EDN08461.1 - 1.1e-08 35.3 0.0 2.4e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN08461.1 - 5.7e-07 29.5 6.0 8.7e-06 25.8 6.0 2.4 1 1 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 EDN08461.1 - 0.00031 20.3 0.0 0.025 14.1 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Mtf2_C PF14061.6 EDN08461.1 - 0.018 15.2 1.0 0.26 11.5 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 RT_RNaseH_2 PF17919.1 EDN08461.1 - 0.066 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase PSII_Pbs27 PF13326.6 EDN08461.1 - 0.096 13.0 0.0 0.52 10.6 0.0 2.1 2 0 0 2 2 2 0 Photosystem II Pbs27 RVT_1 PF00078.27 EDN08462.1 - 1.6e-32 112.9 0.0 2.4e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN08462.1 - 2e-13 50.2 0.0 5.8e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN08462.1 - 0.00026 20.6 0.1 0.00049 19.7 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Kdo PF06293.14 EDN08463.1 - 0.00023 20.6 0.1 0.00055 19.4 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDN08463.1 - 0.01 15.4 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Cytochrom_C_2 PF01322.20 EDN08463.1 - 0.017 16.0 0.6 0.039 14.8 0.6 1.6 1 0 0 1 1 1 0 Cytochrome C' RIO1 PF01163.22 EDN08463.1 - 0.023 14.3 0.0 0.056 13.0 0.0 1.6 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN08463.1 - 0.044 13.7 0.2 0.044 13.7 0.2 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDN08463.1 - 0.14 11.5 0.0 0.37 10.1 0.0 1.7 1 0 0 1 1 1 0 Protein kinase domain GrpE PF01025.19 EDN08463.1 - 0.14 11.8 3.3 0.9 9.2 2.6 2.3 2 0 0 2 2 2 0 GrpE Menin PF05053.13 EDN08463.1 - 1.6 7.0 3.6 2.9 6.2 3.6 1.3 1 0 0 1 1 1 0 Menin Pinin_SDK_memA PF04696.13 EDN08463.1 - 2.5 8.2 17.4 8.6 6.4 17.4 1.9 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region V-SNARE_C PF12352.8 EDN08464.1 - 0.045 14.0 0.1 0.068 13.5 0.1 1.3 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Nexin_C PF08628.12 EDN08467.1 - 0.009 16.6 0.3 0.013 16.1 0.3 1.2 1 0 0 1 1 1 1 Sorting nexin C terminal DUF5552 PF17706.1 EDN08467.1 - 0.12 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5552) DUF3112 PF11309.8 EDN08468.1 - 5.1e-12 45.7 8.3 2.2e-09 37.1 0.0 2.5 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) DUF2070 PF09843.9 EDN08468.1 - 1.1 7.5 8.8 1.1 7.4 8.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Wzy_C PF04932.15 EDN08468.1 - 1.1 8.9 8.5 4.8 6.8 8.5 2.0 1 1 0 1 1 1 0 O-Antigen ligase FAD_binding_4 PF01565.23 EDN08469.1 - 7.8e-26 90.5 0.7 1.6e-25 89.4 0.7 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EDN08469.1 - 8.3e-05 22.6 0.2 0.00036 20.6 0.1 2.0 2 0 0 2 2 2 1 Berberine and berberine like Metallophos PF00149.28 EDN08470.1 - 2e-38 132.9 0.5 3.5e-38 132.2 0.5 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDN08470.1 - 0.035 14.5 0.1 0.07 13.6 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 EDN08470.1 - 0.12 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain PI31_Prot_N PF11566.8 EDN08471.1 - 1.5e-50 171.1 0.0 2.1e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EDN08471.1 - 1.9e-19 70.6 17.4 1.9e-19 70.6 17.4 2.6 3 1 0 3 3 3 1 PI31 proteasome regulator Sugar_tr PF00083.24 EDN08473.1 - 9.4e-117 390.6 24.6 1.9e-116 389.6 24.6 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN08473.1 - 1.6e-25 89.8 35.3 3.3e-19 69.0 12.2 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily UvdE PF03851.14 EDN08476.1 - 1.9e-108 361.9 0.0 2.5e-108 361.5 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE BCMA-Tall_bind PF09257.10 EDN08476.1 - 0.11 12.6 1.6 0.25 11.5 1.6 1.6 1 0 0 1 1 1 0 BCMA, TALL-1 binding CHZ PF09649.10 EDN08476.1 - 0.11 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Histone chaperone domain CHZ Amino_oxidase PF01593.24 EDN08479.1 - 2.3e-49 168.9 0.6 2.5e-29 102.9 0.2 2.5 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDN08479.1 - 2e-16 60.0 0.1 3.8e-15 55.9 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDN08479.1 - 2.4e-05 23.7 0.0 0.00015 21.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN08479.1 - 8e-05 23.1 1.2 0.0002 21.8 0.4 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDN08479.1 - 0.0006 19.0 0.2 0.00088 18.5 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EDN08479.1 - 0.00069 18.4 0.2 0.0011 17.7 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EDN08479.1 - 0.00078 18.8 0.4 0.0012 18.2 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDN08479.1 - 0.0012 18.5 4.4 0.014 15.0 2.3 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EDN08479.1 - 0.0027 16.8 0.1 0.0042 16.2 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EDN08479.1 - 0.0063 15.8 0.1 0.011 15.0 0.1 1.3 1 0 0 1 1 1 1 Thi4 family 3HCDH_N PF02737.18 EDN08479.1 - 0.022 14.6 0.1 0.038 13.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EDN08479.1 - 0.11 11.8 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDN08479.1 - 0.13 12.2 1.4 0.95 9.4 0.3 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding MICSWaP PF17018.5 EDN08479.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Spore wall protein AlaDh_PNT_C PF01262.21 EDN08479.1 - 0.22 10.8 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Homeodomain PF00046.29 EDN08480.1 - 8.4e-15 54.4 3.7 1.9e-14 53.2 3.7 1.6 1 0 0 1 1 1 1 Homeodomain NmrA PF05368.13 EDN08481.1 - 7.1e-08 32.3 0.0 2.4e-07 30.6 0.0 1.8 2 1 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EDN08481.1 - 1e-06 28.7 0.0 1.1e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding FAD_binding_4 PF01565.23 EDN08482.1 - 2.7e-20 72.6 0.1 3.9e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DSPn PF14671.6 EDN08484.1 - 8.7e-42 142.9 0.0 2.3e-39 135.1 0.0 2.6 2 1 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EDN08484.1 - 1.4e-17 63.8 0.1 3.4e-17 62.5 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDN08484.1 - 7.2e-06 25.7 0.0 2.9e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Pcc1 PF09341.10 EDN08485.1 - 6.5e-35 119.1 0.2 8.2e-35 118.8 0.2 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 TT_ORF2 PF02957.15 EDN08485.1 - 0.0092 16.9 1.7 0.013 16.4 1.7 1.1 1 0 0 1 1 1 1 TT viral ORF2 PRR18 PF15671.5 EDN08485.1 - 0.078 12.9 7.5 0.095 12.6 7.5 1.1 1 0 0 1 1 1 0 Proline-rich protein family 18 Translin PF01997.16 EDN08486.1 - 4.4e-13 49.7 0.0 6.8e-13 49.1 0.0 1.3 1 1 0 1 1 1 1 Translin family HR1 PF02185.16 EDN08486.1 - 0.012 15.7 0.4 0.02 15.0 0.4 1.3 1 0 0 1 1 1 0 Hr1 repeat DUF4735 PF15882.5 EDN08486.1 - 0.045 13.2 0.1 0.065 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) Apolipoprotein PF01442.18 EDN08486.1 - 0.065 13.1 1.3 0.13 12.1 0.9 1.5 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain PLAC9 PF15205.6 EDN08486.1 - 0.072 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Placenta-specific protein 9 GSHPx PF00255.19 EDN08487.1 - 4.8e-38 129.1 0.0 6.2e-38 128.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EDN08487.1 - 0.096 12.6 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 AhpC/TSA family Ribosomal_L22e PF01776.17 EDN08488.1 - 5e-39 133.0 0.2 7.8e-39 132.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family AlgF PF11182.8 EDN08488.1 - 0.055 13.2 0.0 0.075 12.8 0.0 1.2 1 0 0 1 1 1 0 Alginate O-acetyl transferase AlgF Hydrolase_6 PF13344.6 EDN08490.1 - 3.7e-22 78.4 0.0 6.2e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN08490.1 - 1.4e-12 47.5 0.0 8.2e-12 45.0 0.0 2.3 2 1 0 2 2 2 1 HAD-hyrolase-like Pmp3 PF01679.17 EDN08491.1 - 1.5e-25 89.1 9.0 1.7e-25 88.9 9.0 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ATP-synt_C PF00137.21 EDN08493.1 - 1.1e-34 118.6 34.9 3.6e-20 72.0 15.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DDE_1 PF03184.19 EDN08495.1 - 1.1e-33 116.3 0.0 2.1e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN08495.1 - 1.3e-05 25.0 0.0 0.00044 20.0 0.0 2.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN08495.1 - 0.0085 16.1 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-CCHC_6 PF15288.6 EDN08495.1 - 0.049 13.5 0.7 0.49 10.3 0.1 2.5 2 0 0 2 2 2 0 Zinc knuckle G-alpha PF00503.20 EDN08496.1 - 4.5e-98 328.7 0.2 1.4e-75 254.7 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 EDN08496.1 - 2.3e-14 53.2 0.6 1.1e-09 37.9 0.0 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDN08496.1 - 9.8e-07 28.4 0.3 0.0052 16.2 0.1 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EDN08496.1 - 0.0029 17.8 0.0 0.89 9.8 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EDN08496.1 - 0.0074 15.7 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein MMR_HSR1 PF01926.23 EDN08496.1 - 0.0094 16.0 0.0 2.9 8.0 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EDN08496.1 - 0.025 15.1 0.0 0.033 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EDN08496.1 - 0.045 13.3 0.0 5.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EDN08496.1 - 0.062 13.1 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2231 PF09990.9 EDN08496.1 - 0.087 13.3 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) AAA_16 PF13191.6 EDN08496.1 - 0.089 13.2 0.0 0.24 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain SRR1 PF07985.12 EDN08497.1 - 0.12 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 SRR1 YabA PF06156.13 EDN08499.1 - 5.3 7.7 22.2 1.1e+02 3.5 5.4 3.0 1 1 1 2 2 2 0 Initiation control protein YabA Spermine_synth PF01564.17 EDN08500.1 - 1.1e-72 243.4 0.0 1.4e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EDN08500.1 - 1.7e-24 85.4 0.1 2.9e-24 84.7 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EDN08500.1 - 3.3e-05 24.5 0.0 6.7e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN08500.1 - 0.004 17.9 0.2 0.016 15.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EDN08500.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 EDN08500.1 - 0.026 14.4 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EDN08500.1 - 0.063 14.3 0.0 0.16 13.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Transketolase_N PF00456.21 EDN08501.1 - 1.4e-126 422.0 0.0 2.1e-126 421.4 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EDN08501.1 - 9.7e-46 155.7 0.0 1.6e-45 154.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDN08501.1 - 5.3e-12 45.7 0.0 1.1e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EDN08501.1 - 0.00062 19.1 0.1 0.0061 15.8 0.1 1.9 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EDN08501.1 - 0.0096 15.7 2.7 0.047 13.5 2.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Beta_elim_lyase PF01212.21 EDN08501.1 - 0.016 14.5 0.1 0.029 13.6 0.1 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase zf-RING_13 PF17977.1 EDN08501.1 - 0.058 13.5 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain E1_dh PF00676.20 EDN08501.1 - 0.074 12.0 0.5 0.11 11.4 0.5 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component Mur_ligase_C PF02875.21 EDN08501.1 - 0.15 12.3 0.0 0.82 10.0 0.0 2.2 2 0 0 2 2 2 0 Mur ligase family, glutamate ligase domain PFO_beta_C PF12367.8 EDN08501.1 - 0.19 11.9 0.0 1 9.6 0.0 2.2 3 0 0 3 3 3 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal RVT_1 PF00078.27 EDN08502.1 - 1.3e-40 139.3 0.0 2e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN08502.1 - 2e-13 50.2 0.0 6.2e-13 48.6 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN08502.1 - 0.00026 20.6 0.1 0.00052 19.6 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN08502.1 - 4.4 7.5 8.7 1.6 8.9 4.8 2.4 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 EDN08503.1 - 0.0012 19.0 0.0 0.0015 18.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN08504.1 - 2.4e-10 40.1 0.6 6.2e-10 38.8 0.6 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EDN08504.1 - 5.1e-10 39.6 0.0 1.2e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RNase_H PF00075.24 EDN08505.1 - 1.1e-12 48.3 0.0 2.4e-12 47.2 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN08505.1 - 0.079 12.8 0.1 0.27 11.1 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like TUTF7_u4 PF16631.5 EDN08506.1 - 0.015 15.9 0.0 0.018 15.6 0.0 1.1 1 0 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 DUF2148 PF09918.9 EDN08507.1 - 0.16 12.0 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) Fungal_trans PF04082.18 EDN08508.1 - 2.3e-30 105.6 0.0 4.1e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN08508.1 - 2.6e-08 33.8 14.7 4.6e-08 33.0 14.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trimer_CC PF08954.11 EDN08508.1 - 0.23 11.1 0.6 0.66 9.6 0.6 1.8 1 0 0 1 1 1 0 Trimerisation motif SET PF00856.28 EDN08509.1 - 0.0028 18.1 0.0 0.0057 17.0 0.0 1.5 1 1 0 1 1 1 1 SET domain MMR_HSR1_C PF08438.10 EDN08511.1 - 1.7e-36 125.2 0.0 2.9e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EDN08511.1 - 3.6e-13 49.6 0.1 1.4e-12 47.7 0.0 2.2 2 1 1 3 3 3 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDN08511.1 - 0.0028 17.0 0.0 0.0054 16.1 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EDN08511.1 - 0.0051 16.7 0.2 0.058 13.3 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 EDN08511.1 - 0.0055 16.5 0.1 1 9.1 0.0 2.3 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EDN08511.1 - 0.0091 15.5 0.2 1.3 8.6 0.0 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EDN08511.1 - 0.034 13.7 0.1 0.47 10.0 0.0 2.6 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDN08511.1 - 0.041 13.9 0.1 0.88 9.6 0.0 2.6 3 0 0 3 3 3 0 Dynamin family Ribosomal_L7Ae PF01248.26 EDN08512.1 - 2.1e-18 65.8 3.9 4.4e-18 64.8 1.4 2.5 2 1 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ndc1_Nup PF09531.10 EDN08512.1 - 0.46 9.1 3.3 0.65 8.6 3.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4050 PF13259.6 EDN08512.1 - 2.9 8.2 7.5 1.1 9.6 5.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) UcrQ PF02939.16 EDN08513.1 - 5.5e-34 115.9 0.2 6.2e-34 115.8 0.2 1.0 1 0 0 1 1 1 1 UcrQ family Band_7 PF01145.25 EDN08514.1 - 3.7e-24 85.7 8.2 3.7e-24 85.7 8.2 1.7 2 1 0 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EDN08514.1 - 0.0021 17.2 3.5 0.0031 16.6 3.5 1.3 1 0 0 1 1 1 1 SigmaW regulon antibacterial GatB_Yqey PF02637.18 EDN08514.1 - 0.067 13.1 0.3 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 GatB domain AAA_lid_4 PF17864.1 EDN08514.1 - 0.46 10.3 4.5 0.15 11.9 0.5 2.3 2 1 1 3 3 3 0 RuvB AAA lid domain AA_permease PF00324.21 EDN08515.1 - 1.4e-106 357.0 40.6 1.6e-80 271.1 19.2 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EDN08515.1 - 8e-23 80.9 39.7 1e-16 60.9 21.0 2.2 2 0 0 2 2 2 2 Amino acid permease HTH_32 PF13565.6 EDN08516.1 - 5e-05 23.8 1.2 0.21 12.2 0.9 2.6 2 0 0 2 2 2 2 Homeodomain-like domain HTH_38 PF13936.6 EDN08516.1 - 8.3e-05 22.3 2.4 0.00014 21.5 1.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 EDN08516.1 - 0.00016 21.4 1.5 0.00048 19.8 0.6 2.1 2 1 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EDN08516.1 - 0.00034 20.2 0.1 0.0011 18.5 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 PPO1_DWL PF12142.8 EDN08516.1 - 0.058 13.2 0.0 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Polyphenol oxidase middle domain Sigma70_r4 PF04545.16 EDN08516.1 - 0.082 12.4 0.2 0.19 11.3 0.2 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.6 EDN08516.1 - 0.087 13.0 0.2 1 9.5 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Adeno_100 PF02438.16 EDN08516.1 - 0.21 9.7 0.0 0.26 9.4 0.0 1.1 1 0 0 1 1 1 0 Late 100kD protein Cutinase PF01083.22 EDN08517.1 - 6.6e-41 140.2 0.0 7.7e-41 140.0 0.0 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EDN08517.1 - 0.0029 17.2 0.0 0.0039 16.8 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain Lipase PF00151.19 EDN08517.1 - 0.027 13.8 0.0 0.034 13.4 0.0 1.1 1 0 0 1 1 1 0 Lipase IncD PF17628.2 EDN08517.1 - 1.2 8.9 5.1 0.74 9.6 0.1 2.1 2 0 0 2 2 2 0 Inclusion membrane protein D Methyltransf_34 PF11312.8 EDN08519.1 - 2.4e-85 286.5 0.0 2.7e-76 256.8 0.0 2.0 1 1 1 2 2 2 2 Putative SAM-dependent methyltransferase DUF938 PF06080.12 EDN08519.1 - 0.019 14.7 0.1 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF938) APH PF01636.23 EDN08521.1 - 5.5e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family CN_hydrolase PF00795.22 EDN08522.1 - 3.3e-14 52.8 0.0 3.8e-13 49.4 0.0 2.1 1 1 1 2 2 2 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EDN08522.1 - 4e-06 26.1 0.0 0.002 17.3 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Phage_lysozyme PF00959.19 EDN08523.1 - 3e-14 53.4 0.0 8.1e-14 52.0 0.0 1.7 2 0 0 2 2 2 1 Phage lysozyme DUF382 PF04037.13 EDN08524.1 - 4.3e-60 201.4 1.4 6.7e-60 200.8 1.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EDN08524.1 - 1.4e-20 72.9 3.8 1.4e-20 72.9 3.8 1.9 2 0 0 2 2 2 1 PSP DUF202 PF02656.15 EDN08526.1 - 1.8e-18 66.8 6.0 1.8e-18 66.8 6.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF202) SUIM_assoc PF16619.5 EDN08526.1 - 0.0004 20.4 8.1 0.00064 19.7 2.5 2.8 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 CNDH2_M PF16869.5 EDN08526.1 - 0.29 11.8 10.8 0.61 10.8 1.0 2.3 2 0 0 2 2 2 0 PF16858 DUF5421 PF17458.2 EDN08526.1 - 1.8 7.9 5.5 16 4.7 3.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5421) KCNQ2_u3 PF16642.5 EDN08526.1 - 5.3 8.1 15.5 0.38 11.8 5.1 2.9 2 1 1 3 3 3 0 Unstructured region on Potassium channel subunit alpha KvLQT2 PTPA PF03095.15 EDN08527.1 - 1.6e-106 356.2 0.0 1.9e-106 355.9 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF1754 PF08555.10 EDN08528.1 - 2.2e-16 60.4 8.0 3.6e-16 59.8 8.0 1.3 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) MFMR_assoc PF16596.5 EDN08528.1 - 1.3 9.5 7.1 2.1 8.8 7.1 1.4 1 1 0 1 1 1 0 Disordered region downstream of MFMR AC_N PF16214.5 EDN08528.1 - 6.9 5.7 9.1 7.5 5.6 9.1 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region zf-AN1 PF01428.16 EDN08529.1 - 1.6e-12 47.3 6.8 3.5e-12 46.3 6.8 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EDN08529.1 - 0.013 15.9 4.1 0.013 15.9 4.1 1.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Stc1 PF12898.7 EDN08531.1 - 0.002 18.6 3.0 0.0027 18.2 0.7 2.3 2 1 0 2 2 2 1 Stc1 domain F-box PF00646.33 EDN08531.1 - 0.0083 16.0 0.1 0.025 14.5 0.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN08531.1 - 0.029 14.3 0.2 0.067 13.1 0.2 1.6 1 0 0 1 1 1 0 F-box-like C1_4 PF07975.12 EDN08531.1 - 0.062 13.6 2.6 0.11 12.8 0.3 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain DZR PF12773.7 EDN08531.1 - 0.25 11.4 5.4 47 4.1 5.4 3.1 1 1 0 1 1 1 0 Double zinc ribbon DUF1752 PF08550.10 EDN08532.1 - 1.4e-12 47.2 2.6 2.6e-12 46.3 2.6 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) AreA_N PF07573.11 EDN08532.1 - 0.0055 17.3 0.0 0.0055 17.3 0.0 3.9 2 1 0 3 3 3 1 Nitrogen regulatory protein AreA N terminus NinD PF17466.2 EDN08532.1 - 0.081 13.0 0.8 0.22 11.6 0.8 1.7 1 0 0 1 1 1 0 Family of unknown function Zn_clus PF00172.18 EDN08535.1 - 0.064 13.4 5.0 0.1 12.8 5.0 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MADF_DNA_bdg PF10545.9 EDN08536.1 - 0.15 12.4 0.2 0.29 11.5 0.2 1.5 1 1 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DLH PF01738.18 EDN08537.1 - 1.1e-09 38.2 0.1 1.5e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family zf-C2H2 PF00096.26 EDN08538.1 - 1.7e-11 43.9 11.3 3.8e-05 23.9 0.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN08538.1 - 2.5e-09 37.2 8.8 0.00035 21.2 0.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDN08538.1 - 3.8e-08 33.4 10.3 2.9e-06 27.4 1.8 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDN08538.1 - 0.0011 18.9 5.7 0.39 10.8 1.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDN08538.1 - 0.0064 16.8 2.8 0.014 15.7 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 EDN08538.1 - 0.014 15.0 0.6 5.2 6.8 0.1 2.4 2 0 0 2 2 2 0 MYST family zinc finger domain zf-C2H2_11 PF16622.5 EDN08538.1 - 0.14 11.9 3.2 5.8 6.8 0.1 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf_UBZ PF18439.1 EDN08538.1 - 0.16 11.6 2.2 11 5.7 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-H2C2_5 PF13909.6 EDN08538.1 - 0.32 10.8 0.2 0.32 10.8 0.2 3.4 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.6 EDN08538.1 - 2.3 8.2 5.4 0.34 10.9 1.2 1.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 EDN08538.1 - 3 8.4 6.8 13 6.3 0.7 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 EDN08538.1 - 4.7 7.5 7.9 18 5.6 2.0 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger Pyridoxal_deC PF00282.19 EDN08539.1 - 4.2e-60 203.4 0.0 5.9e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDN08539.1 - 0.00019 20.5 0.0 0.00028 20.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Fungal_trans_2 PF11951.8 EDN08540.1 - 4.3e-60 203.5 0.8 6.1e-60 203.1 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pkinase PF00069.25 EDN08541.1 - 5.3e-41 140.7 0.1 4.1e-39 134.5 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08541.1 - 3.2e-20 72.5 0.1 5e-20 71.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN08541.1 - 0.00025 20.4 0.2 0.00062 19.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 EDN08541.1 - 0.0022 18.7 0.5 0.0068 17.1 0.5 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 EDN08541.1 - 0.0034 17.3 7.6 0.44 10.4 0.0 4.0 2 2 2 4 4 4 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDN08541.1 - 0.0085 15.1 0.1 0.018 14.0 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain DUF1687 PF07955.11 EDN08542.1 - 8.6e-30 103.8 0.0 1e-29 103.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) NAD_binding_2 PF03446.15 EDN08542.1 - 0.078 13.1 0.0 0.089 13.0 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Abhydrolase_2 PF02230.16 EDN08543.1 - 1.5e-42 145.9 0.0 2.5e-41 141.9 0.0 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EDN08543.1 - 1.2e-05 24.9 0.0 0.003 17.1 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EDN08543.1 - 5.8e-05 23.0 0.0 0.046 13.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 EDN08543.1 - 0.0058 16.2 0.0 0.014 14.9 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EDN08543.1 - 0.014 14.6 0.3 0.57 9.4 0.0 2.7 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDN08543.1 - 0.086 13.4 0.0 0.5 10.9 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase family FSH1 PF03959.13 EDN08543.1 - 0.21 11.2 0.1 0.4 10.3 0.1 1.5 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Cutinase PF01083.22 EDN08543.1 - 0.21 11.5 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Cutinase Ctr PF04145.15 EDN08545.1 - 2.5e-32 112.5 0.1 3.1e-32 112.3 0.1 1.0 1 0 0 1 1 1 1 Ctr copper transporter family Ferric_reduct PF01794.19 EDN08546.1 - 2.7e-19 69.5 10.6 5.3e-19 68.6 10.6 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EDN08546.1 - 1.4e-18 67.5 0.0 2.4e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDN08546.1 - 3.1e-18 65.9 0.0 6.1e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain adh_short PF00106.25 EDN08548.1 - 5.3e-20 71.7 0.0 1.8e-15 57.0 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN08548.1 - 1.1e-08 34.9 0.0 3.5e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN08548.1 - 5.6e-06 26.4 0.0 9.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDN08548.1 - 0.034 13.3 0.0 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDN08548.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_S28 PF05577.12 EDN08548.1 - 0.18 10.6 0.0 0.32 9.7 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 NAC PF01849.18 EDN08552.1 - 1.3e-23 82.8 0.2 2.4e-23 81.9 0.2 1.5 1 0 0 1 1 1 1 NAC domain CENP-Q PF13094.6 EDN08552.1 - 0.068 13.4 1.3 2 8.6 1.3 2.1 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Fungal_trans PF04082.18 EDN08553.1 - 2.8e-11 43.0 0.1 5.1e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ank_2 PF12796.7 EDN08553.1 - 6.6e-08 33.0 0.0 4.5e-07 30.4 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN08553.1 - 0.0015 19.1 0.1 0.0071 16.9 0.1 2.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) zf-C2H2 PF00096.26 EDN08553.1 - 0.0021 18.4 0.9 0.0068 16.8 0.9 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type Ank PF00023.30 EDN08553.1 - 0.0046 17.4 5.5 0.056 13.9 0.1 3.4 4 0 0 4 4 4 1 Ankyrin repeat zf-C2H2_4 PF13894.6 EDN08553.1 - 0.072 14.0 0.5 0.27 12.2 0.5 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger Ank_3 PF13606.6 EDN08553.1 - 0.15 12.7 0.1 35 5.4 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat FAM124 PF15067.6 EDN08554.1 - 0.18 11.4 0.1 0.23 11.1 0.1 1.0 1 0 0 1 1 1 0 FAM124 family Ag332 PF04671.12 EDN08555.1 - 0.088 12.8 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Erythrocyte membrane-associated giant protein antigen 332 BTB PF00651.31 EDN08556.1 - 2.6e-22 79.1 0.0 2.1e-13 50.5 0.4 2.6 2 0 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.7 EDN08556.1 - 2.3e-06 28.1 0.0 5.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN08556.1 - 2.3e-06 28.0 0.0 8e-06 26.3 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN08556.1 - 3.1e-05 24.2 0.1 0.00011 22.5 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EDN08556.1 - 0.00018 21.8 0.1 0.0052 17.2 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EDN08556.1 - 0.018 15.5 0.1 0.13 12.9 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat YqzH PF14164.6 EDN08556.1 - 0.25 11.5 1.9 36 4.5 0.0 3.4 3 0 0 3 3 3 0 YqzH-like protein Pkinase PF00069.25 EDN08557.1 - 2.3e-54 184.5 0.1 1e-35 123.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08557.1 - 2.8e-35 121.9 0.0 5.5e-25 88.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDN08557.1 - 0.0015 17.9 0.0 0.0043 16.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDN08557.1 - 0.0049 15.7 1.1 0.1 11.4 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase DUF3896 PF13035.6 EDN08557.1 - 4.5 7.5 6.8 0.55 10.4 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) Wbp11 PF09429.10 EDN08559.1 - 1.3e-23 83.2 14.4 2.4e-23 82.3 14.4 1.5 1 0 0 1 1 1 1 WW domain binding protein 11 DUF1664 PF07889.12 EDN08560.1 - 0.031 14.3 1.4 0.098 12.7 1.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) M16C_assoc PF08367.11 EDN08560.1 - 0.054 12.6 0.4 0.14 11.3 0.2 1.7 1 1 0 1 1 1 0 Peptidase M16C associated DUF3482 PF11981.8 EDN08560.1 - 0.054 12.9 2.9 0.039 13.3 1.5 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3482) Fib_alpha PF08702.10 EDN08560.1 - 0.096 12.9 2.6 0.17 12.0 2.6 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EDN08560.1 - 0.096 13.0 1.7 0.56 10.5 0.9 2.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Adenylsucc_synt PF00709.21 EDN08560.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate synthetase DUF948 PF06103.11 EDN08560.1 - 0.12 12.6 0.2 0.58 10.4 0.2 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.11 EDN08560.1 - 0.15 10.0 0.3 0.19 9.7 0.3 1.1 1 0 0 1 1 1 0 Prominin Pox_A_type_inc PF04508.12 EDN08560.1 - 0.74 9.8 0.1 0.74 9.8 0.1 3.3 3 1 1 4 4 4 0 Viral A-type inclusion protein repeat Rpr2 PF04032.16 EDN08561.1 - 3e-28 97.9 0.9 5.3e-28 97.1 0.9 1.4 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DEAD PF00270.29 EDN08562.1 - 1.8e-34 119.0 0.0 3.9e-34 117.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN08562.1 - 2.7e-26 92.1 0.0 1.5e-24 86.4 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN08562.1 - 1.5e-07 31.6 0.0 2.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDN08562.1 - 0.015 14.7 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ApbA PF02558.16 EDN08563.1 - 3e-27 95.1 0.0 4.4e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EDN08563.1 - 2.4e-26 92.4 0.0 3.7e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DASH_Hsk3 PF08227.11 EDN08564.1 - 9.5e-21 73.9 2.7 1.9e-20 72.9 2.7 1.6 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like ATG16 PF08614.11 EDN08564.1 - 0.015 15.6 4.2 0.017 15.4 4.2 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TMEM43 PF07787.12 EDN08564.1 - 0.027 13.9 3.1 0.032 13.6 3.1 1.0 1 0 0 1 1 1 0 Transmembrane protein 43 Filament PF00038.21 EDN08564.1 - 0.045 13.3 1.9 0.058 13.0 1.9 1.0 1 0 0 1 1 1 0 Intermediate filament protein GOLGA2L5 PF15070.6 EDN08564.1 - 0.045 12.4 0.1 0.054 12.1 0.1 1.0 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 Not3 PF04065.15 EDN08564.1 - 0.16 11.4 0.7 0.19 11.2 0.7 1.1 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component NUDE_C PF04880.13 EDN08564.1 - 0.3 11.5 9.2 0.37 11.2 9.2 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region ASD2 PF08687.11 EDN08564.1 - 0.44 10.1 3.4 0.54 9.8 3.4 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Lin-8 PF03353.15 EDN08564.1 - 2.1 7.8 10.2 2.8 7.4 10.2 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Tmemb_cc2 PF10267.9 EDN08564.1 - 2.3 7.3 7.5 2.8 7.0 7.5 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ANAPC1 PF12859.7 EDN08564.1 - 5.3 7.6 10.7 7.7 7.1 10.7 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 EVI2A PF05399.11 EDN08564.1 - 9.1 5.8 12.1 12 5.4 12.1 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) His_Phos_1 PF00300.22 EDN08565.1 - 4e-31 108.2 1.7 5.4e-30 104.5 1.7 2.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lipase_3 PF01764.25 EDN08566.1 - 9.4e-18 64.4 0.0 2.7e-12 46.8 0.0 2.5 1 1 1 2 2 2 2 Lipase (class 3) Abhydrolase_6 PF12697.7 EDN08566.1 - 0.012 16.2 2.5 0.026 15.1 2.5 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family RGS PF00615.19 EDN08567.1 - 6.9e-09 36.0 0.1 2.2e-06 28.0 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain RBM39linker PF15519.6 EDN08567.1 - 0.027 15.5 0.1 0.074 14.1 0.1 1.7 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Takusan PF04822.13 EDN08567.1 - 0.063 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Takusan SecE PF00584.20 EDN08567.1 - 2 8.4 3.9 4.7 7.2 3.9 1.6 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex SMC_N PF02463.19 EDN08568.1 - 1.9e-17 63.4 0.4 2.1e-12 47.0 0.2 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDN08568.1 - 7.6e-05 22.7 2.8 0.12 12.2 0.2 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDN08568.1 - 0.0004 20.9 14.7 0.0004 20.9 14.7 5.6 2 2 0 2 2 2 1 AAA domain Bacillus_HBL PF05791.11 EDN08568.1 - 0.0058 16.5 0.7 0.0058 16.5 0.7 3.7 4 1 0 4 4 4 1 Bacillus haemolytic enterotoxin (HBL) AAA_29 PF13555.6 EDN08568.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_13 PF13166.6 EDN08568.1 - 0.84 8.2 46.5 0.19 10.3 9.2 4.2 3 1 1 4 4 4 0 AAA domain AAA_27 PF13514.6 EDN08568.1 - 1.1 8.8 0.0 1.1 8.8 0.0 4.0 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 EDN08568.1 - 1.3 9.5 0.0 1.3 9.5 0.0 3.5 4 2 0 4 4 4 0 ABC transporter AAA_22 PF13401.6 EDN08568.1 - 1.5 9.1 4.9 19 5.5 0.0 3.8 3 0 0 3 3 3 0 AAA domain Prominin PF05478.11 EDN08568.1 - 8.3 4.2 19.2 0.037 12.0 3.8 2.6 2 1 0 2 2 2 0 Prominin AdoMet_MTase PF07757.13 EDN08569.1 - 5.1e-34 117.0 0.0 1.9e-33 115.1 0.0 2.0 2 1 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase DUF3237 PF11578.8 EDN08570.1 - 6.2e-37 126.7 0.0 8.8e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) zf-BED PF02892.15 EDN08570.1 - 0.00056 19.9 5.5 0.18 11.9 0.5 2.6 3 0 0 3 3 3 2 BED zinc finger zf-C2H2_2 PF12756.7 EDN08570.1 - 0.22 11.9 6.8 5.5 7.4 0.7 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.15 EDN08570.1 - 1.1 9.3 6.0 7.4 6.6 0.5 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn_Tnp_IS91 PF14319.6 EDN08570.1 - 2.1 8.5 11.7 2.5 8.2 1.9 2.3 2 0 0 2 2 2 0 Transposase zinc-binding domain Gln-synt_C PF00120.24 EDN08571.1 - 2.7e-75 253.6 0.0 1.1e-73 248.3 0.0 2.0 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain adh_short_C2 PF13561.6 EDN08572.1 - 5.6e-60 202.8 0.2 6.3e-60 202.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN08572.1 - 2.5e-41 141.3 0.1 3.1e-41 141.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN08572.1 - 3.5e-11 43.4 0.9 5.2e-11 42.8 0.9 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EDN08572.1 - 0.00024 21.0 0.2 0.00045 20.2 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EDN08572.1 - 0.0007 20.2 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 EDN08572.1 - 0.0028 16.8 0.0 0.004 16.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Methyltransf_12 PF08242.12 EDN08572.1 - 0.03 15.0 0.0 0.058 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EDN08572.1 - 0.064 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ldh_1_N PF00056.23 EDN08572.1 - 0.065 13.3 0.6 0.18 11.9 0.4 1.8 1 1 1 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Rad21_Rec8_N PF04825.13 EDN08573.1 - 1.1e-33 115.6 0.1 4.8e-33 113.6 0.0 2.0 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EDN08573.1 - 0.00013 21.2 0.1 0.00027 20.2 0.1 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein AAA_lid_4 PF17864.1 EDN08573.1 - 0.14 11.9 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 RuvB AAA lid domain NAT PF04768.13 EDN08574.1 - 6.7e-53 178.8 0.0 1.3e-52 177.9 0.0 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EDN08574.1 - 2.2e-30 105.6 0.0 1.2e-29 103.2 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 EDN08574.1 - 2.4e-27 96.1 0.5 8e-27 94.4 0.1 2.0 2 0 0 2 2 2 1 Amino acid kinase family DapB_N PF01113.20 EDN08574.1 - 0.13 12.3 0.0 0.41 10.8 0.0 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Synaptobrevin PF00957.21 EDN08575.1 - 2e-32 110.8 0.8 2.3e-32 110.6 0.8 1.0 1 0 0 1 1 1 1 Synaptobrevin Methyltransf_23 PF13489.6 EDN08576.1 - 1.2e-18 67.5 0.0 2e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN08576.1 - 3.4e-13 50.1 0.0 2.1e-12 47.6 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN08576.1 - 1e-11 45.3 0.0 3.6e-11 43.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN08576.1 - 8.7e-09 35.3 0.0 0.001 18.9 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDN08576.1 - 4.1e-08 33.9 0.0 6.3e-07 30.1 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN08576.1 - 0.00043 19.7 0.0 0.0038 16.6 0.0 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EDN08576.1 - 0.0013 18.5 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EDN08576.1 - 0.0019 17.8 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EDN08576.1 - 0.0024 18.0 0.0 0.0061 16.7 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase PrmA PF06325.13 EDN08576.1 - 0.0083 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EDN08576.1 - 0.013 14.8 0.0 1.2 8.3 0.0 2.6 3 0 0 3 3 3 0 O-methyltransferase domain CMAS PF02353.20 EDN08576.1 - 0.014 14.7 0.0 0.03 13.6 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EDN08576.1 - 0.018 14.5 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase RFamide_26RFa PF11109.8 EDN08576.1 - 0.088 13.3 0.0 4.8 7.7 0.0 2.4 2 1 0 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 DUF938 PF06080.12 EDN08576.1 - 0.099 12.4 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Glyco_hydro_76 PF03663.14 EDN08578.1 - 1e-130 436.5 8.3 1.2e-130 436.3 8.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EDN08578.1 - 4.7 6.2 8.6 0.81 8.7 0.1 3.0 2 1 1 4 4 4 0 Glycosyl Hydrolase Family 88 CBP4 PF07960.11 EDN08579.1 - 7.3e-28 97.0 4.0 1.4e-27 96.1 4.0 1.4 1 1 0 1 1 1 1 CBP4 APG6_N PF17675.1 EDN08579.1 - 0.0043 17.6 8.2 0.0057 17.2 8.2 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF4574 PF15141.6 EDN08579.1 - 0.0079 16.1 1.6 0.03 14.2 0.0 2.0 1 1 1 2 2 2 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 YflT PF11181.8 EDN08579.1 - 0.12 12.9 2.4 0.17 12.4 2.4 1.3 1 0 0 1 1 1 0 Heat induced stress protein YflT Tmemb_161AB PF10268.9 EDN08579.1 - 0.2 10.2 0.0 0.3 9.7 0.0 1.3 1 1 0 1 1 1 0 Predicted transmembrane protein 161AB Sel1 PF08238.12 EDN08580.1 - 4.1e-48 160.7 26.2 2.2e-09 37.7 0.3 7.5 7 0 0 7 7 7 7 Sel1 repeat TPR_20 PF14561.6 EDN08580.1 - 0.15 12.4 1.0 0.26 11.7 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat LigB PF02900.18 EDN08581.1 - 5.9e-30 104.3 0.0 2.3e-20 72.8 0.0 2.0 2 0 0 2 2 2 2 Catalytic LigB subunit of aromatic ring-opening dioxygenase L51_S25_CI-B8 PF05047.16 EDN08582.1 - 1.9e-11 43.7 0.0 2.5e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MPC PF03650.13 EDN08583.1 - 7.7e-34 116.1 0.0 9.3e-34 115.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers ADH_N PF08240.12 EDN08584.1 - 2.6e-26 91.6 3.5 5.1e-26 90.7 3.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN08584.1 - 3.5e-18 65.8 0.1 8e-18 64.7 0.1 1.6 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDN08584.1 - 6.5e-06 27.2 0.0 1.3e-05 26.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDN08584.1 - 1.4e-05 24.7 0.5 3.6e-05 23.4 0.5 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EDN08584.1 - 0.0018 17.6 0.4 0.0035 16.7 0.4 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EDN08584.1 - 0.064 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.21 EDN08584.1 - 0.11 11.9 0.4 0.24 10.7 0.4 1.5 1 1 0 1 1 1 0 ThiF family Malate_synthase PF01274.22 EDN08585.1 - 2.4e-230 765.3 0.0 2.7e-230 765.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Glyco_hydro_3_C PF01915.22 EDN08586.1 - 5.9e-44 150.5 0.0 1e-43 149.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EDN08586.1 - 1.7e-37 129.5 0.0 2.5e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EDN08586.1 - 1.7e-19 69.7 2.5 1.9e-18 66.4 2.5 2.3 1 1 0 1 1 1 1 Fibronectin type III-like domain AA_permease_2 PF13520.6 EDN08587.1 - 1.3e-50 172.5 50.7 1.6e-50 172.2 50.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDN08587.1 - 1.2e-23 83.5 40.4 1.5e-23 83.1 40.4 1.0 1 0 0 1 1 1 1 Amino acid permease SLATT_5 PF18160.1 EDN08587.1 - 0.058 12.7 0.2 9.6 5.5 0.0 2.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 ABC_tran PF00005.27 EDN08589.1 - 3.2e-47 160.5 0.1 1.1e-25 90.7 0.0 4.0 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EDN08589.1 - 1.8e-15 57.6 0.7 0.00012 22.0 0.0 4.6 3 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDN08589.1 - 1.9e-12 47.1 0.0 0.0015 18.0 0.0 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Chromo PF00385.24 EDN08589.1 - 7.9e-09 35.3 0.1 1.6e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 EDN08589.1 - 1.5e-08 35.4 0.1 0.0008 20.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDN08589.1 - 2e-06 27.4 0.9 0.025 14.3 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDN08589.1 - 1.5e-05 25.0 0.0 0.12 12.5 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDN08589.1 - 2.9e-05 24.1 0.1 0.17 11.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EDN08589.1 - 7.8e-05 22.5 0.0 0.041 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 EDN08589.1 - 0.00016 21.9 1.1 0.059 13.5 0.1 3.1 3 0 0 3 3 3 1 Helicase HerA, central domain DRIM PF07539.12 EDN08589.1 - 0.0004 18.8 1.5 0.00067 18.1 1.5 1.3 1 0 0 1 1 1 1 Down-regulated in metastasis AAA_22 PF13401.6 EDN08589.1 - 0.00056 20.2 0.1 0.5 10.6 0.0 3.2 3 0 0 3 3 2 1 AAA domain MukB PF04310.12 EDN08589.1 - 0.006 16.4 0.2 0.91 9.3 0.0 2.6 2 0 0 2 2 2 1 MukB N-terminal RNA_helicase PF00910.22 EDN08589.1 - 0.0063 16.9 0.2 5.8 7.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 EDN08589.1 - 0.0083 15.9 0.2 5.6 6.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain MeaB PF03308.16 EDN08589.1 - 0.0084 15.1 0.2 2.9 6.8 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EDN08589.1 - 0.0094 15.9 0.6 0.63 9.9 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 EDN08589.1 - 0.011 16.3 0.5 14 6.2 0.0 3.4 3 1 1 4 4 3 0 AAA domain AAA_28 PF13521.6 EDN08589.1 - 0.012 15.8 0.0 0.72 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDN08589.1 - 0.021 15.0 0.1 5.6 7.1 0.0 3.0 3 0 0 3 3 2 0 AAA domain Dynamin_N PF00350.23 EDN08589.1 - 0.024 14.7 0.0 2.1 8.4 0.0 3.3 3 0 0 3 3 3 0 Dynamin family AAA_13 PF13166.6 EDN08589.1 - 0.032 12.9 0.0 1.9 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN08589.1 - 0.043 13.5 0.5 3.4 7.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain HEAT PF02985.22 EDN08589.1 - 0.091 13.1 1.2 1.1e+02 3.5 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat SR-25 PF10500.9 EDN08589.1 - 0.1 12.2 2.2 0.2 11.2 2.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ATP-synt_ab PF00006.25 EDN08589.1 - 0.12 12.0 0.0 19 4.8 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain CAF1-p150_N PF15557.6 EDN08589.1 - 0.17 11.8 0.4 0.35 10.8 0.1 1.6 2 0 0 2 2 1 0 CAF1 complex subunit p150, region binding to PCNA AAA_27 PF13514.6 EDN08589.1 - 0.21 11.2 0.7 11 5.5 0.0 2.6 3 0 0 3 3 2 0 AAA domain DUF3584 PF12128.8 EDN08589.1 - 0.41 8.1 2.2 4.2 4.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) ICL PF00463.21 EDN08590.1 - 3.3e-193 643.0 0.1 3.9e-193 642.7 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EDN08590.1 - 8.4e-09 35.2 0.0 1.7e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Flu_B_NS1 PF02942.14 EDN08590.1 - 0.062 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) DUF2458 PF10454.9 EDN08590.1 - 0.57 9.8 3.1 0.32 10.6 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2458) Citrate_synt PF00285.21 EDN08591.1 - 2.9e-97 326.0 0.0 3.5e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DNA_pol_A_exo1 PF01612.20 EDN08592.1 - 4.5e-10 39.5 0.0 1.7e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 3'-5' exonuclease AMP-binding PF00501.28 EDN08593.1 - 3.3e-60 203.9 0.0 4.6e-32 111.2 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EDN08593.1 - 4e-07 30.9 0.1 9.1e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1661 PF07877.11 EDN08593.1 - 0.16 11.7 0.1 0.44 10.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) CbiA PF01656.23 EDN08593.1 - 0.18 11.8 0.0 0.49 10.5 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Abhydrolase_6 PF12697.7 EDN08594.1 - 1.1e-18 68.7 0.0 1.3e-18 68.4 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN08594.1 - 0.00074 18.9 0.0 0.2 10.9 0.0 2.8 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EDN08594.1 - 0.005 16.7 0.0 0.11 12.4 0.0 2.3 2 1 0 2 2 2 1 Serine hydrolase Abhydrolase_4 PF08386.10 EDN08594.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Lipase_2 PF01674.18 EDN08594.1 - 0.071 12.6 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) MmgE_PrpD PF03972.14 EDN08595.1 - 4.2e-143 477.1 0.0 7.2e-143 476.3 0.0 1.3 1 1 0 1 1 1 1 MmgE/PrpD family Phage_TAC_11 PF11836.8 EDN08595.1 - 0.066 13.3 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 DUF1266 PF06889.11 EDN08595.1 - 0.14 12.2 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) SET PF00856.28 EDN08596.1 - 0.002 18.6 0.0 0.0045 17.4 0.0 1.5 1 1 0 1 1 1 1 SET domain DNA_methylase PF00145.17 EDN08597.1 - 1e-37 130.2 0.0 2.6e-28 99.4 0.0 2.2 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase GATase_6 PF13522.6 EDN08598.1 - 6.1e-12 45.9 0.0 1.4e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDN08598.1 - 2.2e-10 40.5 0.0 4.4e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EDN08598.1 - 3.5e-09 36.4 0.0 6.6e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EDN08598.1 - 0.00011 21.2 0.0 0.00029 19.8 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Mt_ATP-synt_D PF05873.12 EDN08599.1 - 1.2e-22 80.5 0.9 1.4e-22 80.2 0.9 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF4515 PF14988.6 EDN08599.1 - 0.12 12.2 3.4 1.6 8.5 3.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4515) NAC PF01849.18 EDN08600.1 - 2.5e-22 78.6 0.0 4.3e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 NAC domain Ribosomal_L14e PF01929.17 EDN08601.1 - 3.3e-30 104.4 0.9 4.5e-30 104.0 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 RGS PF00615.19 EDN08602.1 - 0.011 16.0 0.0 0.057 13.7 0.0 2.2 1 1 0 1 1 1 0 Regulator of G protein signaling domain MFS_1 PF07690.16 EDN08603.1 - 1.6e-21 76.6 34.8 9.4e-21 74.1 33.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EDN08603.1 - 4.4e-07 29.5 6.7 4.4e-07 29.5 6.7 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_1 PF07690.16 EDN08604.1 - 8e-37 127.0 31.2 2.4e-25 89.2 10.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN08604.1 - 8.7e-13 47.9 14.6 9.1e-12 44.6 4.2 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Folate_carrier PF01770.18 EDN08604.1 - 6e-05 22.0 0.1 0.00011 21.1 0.1 1.4 1 0 0 1 1 1 1 Reduced folate carrier MFS_1_like PF12832.7 EDN08604.1 - 0.0001 21.3 17.8 0.00032 19.7 5.4 3.5 1 1 1 2 2 2 1 MFS_1 like family MFS_4 PF06779.14 EDN08604.1 - 0.00012 21.5 3.9 0.00012 21.5 3.9 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB SRP-alpha_N PF04086.13 EDN08606.1 - 1.2e-82 278.1 0.2 1.6e-82 277.7 0.2 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EDN08606.1 - 2.3e-49 167.7 0.0 4.2e-49 166.9 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EDN08606.1 - 1.4e-10 41.2 0.0 6.6e-10 39.1 0.0 2.2 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EDN08606.1 - 2e-06 27.0 0.0 3.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EDN08606.1 - 0.00074 19.3 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN08606.1 - 0.0035 17.7 0.0 0.013 15.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.23 EDN08606.1 - 0.01 15.9 0.0 0.077 13.1 0.0 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EDN08606.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EDN08606.1 - 0.042 13.8 0.1 0.19 11.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 EDN08606.1 - 0.046 13.2 0.0 0.078 12.4 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MMR_HSR1 PF01926.23 EDN08606.1 - 0.046 13.8 0.2 0.24 11.5 0.2 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 EDN08606.1 - 0.047 13.1 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 EDN08606.1 - 0.06 13.9 0.0 0.21 12.1 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 EDN08606.1 - 0.062 13.7 0.0 0.89 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain FAM60A PF15396.6 EDN08606.1 - 0.075 13.0 1.0 0.13 12.2 1.0 1.4 1 0 0 1 1 1 0 Protein Family FAM60A NTPase_1 PF03266.15 EDN08606.1 - 0.11 12.4 0.4 0.44 10.4 0.1 2.2 2 1 0 2 2 2 0 NTPase DUF87 PF01935.17 EDN08606.1 - 0.51 10.4 2.2 1 9.4 0.1 2.3 3 0 0 3 3 3 0 Helicase HerA, central domain YIF1 PF03878.15 EDN08607.1 - 9.1e-98 326.5 4.7 1.1e-97 326.3 4.7 1.0 1 0 0 1 1 1 1 YIF1 Fungal_trans PF04082.18 EDN08609.1 - 1.1e-09 37.7 0.1 3.2e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Catalase PF00199.19 EDN08610.1 - 1.5e-171 570.7 1.2 1.9e-171 570.4 1.2 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDN08610.1 - 7.3e-16 58.1 0.1 1.8e-15 56.8 0.1 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EDN08610.1 - 8.4e-08 32.0 0.0 2.3e-07 30.6 0.0 1.7 2 0 0 2 2 2 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EDN08610.1 - 0.00064 19.6 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Mpv17_PMP22 PF04117.12 EDN08613.1 - 9.8e-18 64.1 0.1 2.1e-17 63.1 0.1 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family Polysacc_synt_C PF14667.6 EDN08613.1 - 0.043 13.9 0.7 0.043 13.9 0.7 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Rieske PF00355.26 EDN08614.1 - 6.5e-16 58.0 0.0 1.3e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Ring_hydroxyl_A PF00848.19 EDN08614.1 - 5.2e-05 23.3 3.1 0.00024 21.1 0.1 2.7 3 0 0 3 3 3 1 Ring hydroxylating alpha subunit (catalytic domain) RabGAP-TBC PF00566.18 EDN08615.1 - 8.2e-38 130.2 0.6 1.9e-37 129.0 0.6 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EDN08615.1 - 0.0041 16.6 0.0 0.019 14.5 0.0 1.9 2 0 0 2 2 2 1 Rab-binding domain (RBD) GAS2 PF02187.17 EDN08616.1 - 1.5e-05 25.0 0.2 3.1e-05 24.0 0.2 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain HDPD PF02924.14 EDN08616.1 - 0.074 13.2 0.9 0.15 12.1 0.9 1.5 1 0 0 1 1 1 0 Bacteriophage lambda head decoration protein D HTH_7 PF02796.15 EDN08618.1 - 1.8e-07 31.1 0.0 5.1e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN08618.1 - 2.6e-06 27.1 0.0 0.00011 21.9 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN08618.1 - 5.7e-06 25.9 0.0 3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_29 PF13551.6 EDN08618.1 - 7.3e-06 25.9 0.0 5.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN08618.1 - 5.5e-05 22.9 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN08618.1 - 0.00088 19.2 0.0 0.0013 18.6 0.0 1.4 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN08618.1 - 0.023 15.3 0.0 1.2 9.8 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain GerE PF00196.19 EDN08618.1 - 0.036 13.6 0.5 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN08618.1 - 0.046 13.9 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN08618.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN08618.1 - 0.12 12.5 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein Hus1 PF04005.12 EDN08619.1 - 3.5e-111 371.0 0.0 3.9e-111 370.8 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein Sec16_C PF12931.7 EDN08620.1 - 3.9e-109 365.0 0.0 5.5e-109 364.5 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EDN08620.1 - 3.4e-32 111.5 0.0 3.4e-32 111.5 0.0 2.8 2 1 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.7 EDN08620.1 - 8.3e-30 104.7 47.3 2.5e-16 60.6 9.1 5.1 4 1 1 5 5 5 3 Vesicle coat trafficking protein Sec16 N-terminus PhoLip_ATPase_C PF16212.5 EDN08621.1 - 4e-44 151.3 4.2 4e-44 151.3 4.2 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDN08621.1 - 3.4e-16 58.7 1.3 7.1e-16 57.7 1.3 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EDN08621.1 - 1.2e-12 48.6 0.8 1.5e-05 25.4 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDN08621.1 - 6.8e-07 29.3 0.0 2.1e-05 24.5 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EDN08621.1 - 5.3e-06 26.1 2.4 0.0044 16.6 0.0 2.5 2 0 0 2 2 2 2 E1-E2 ATPase DUF3850 PF12961.7 EDN08621.1 - 0.0086 16.1 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3850) HIGH_NTase1_ass PF16581.5 EDN08621.1 - 0.016 15.2 0.0 0.058 13.4 0.0 1.8 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region Hydrolase_3 PF08282.12 EDN08621.1 - 0.023 14.4 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Mso1_Sec1_bdg PF14475.6 EDN08622.1 - 8.7e-14 50.8 0.0 1.8e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Ribosomal_L28e PF01778.17 EDN08623.1 - 4.1e-39 133.9 1.0 6.9e-39 133.2 1.0 1.4 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 EDN08623.1 - 3.2e-30 104.7 14.7 3.2e-30 104.7 14.7 2.3 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EDN08623.1 - 9.4e-07 28.5 20.1 1.2e-06 28.2 20.1 1.1 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 EDN08623.1 - 0.016 13.5 34.8 0.021 13.1 34.8 1.1 1 0 0 1 1 1 0 Nop14-like family Ribosomal_L24e PF01246.20 EDN08623.1 - 0.066 13.4 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L24e SAPS PF04499.15 EDN08623.1 - 1.6 7.4 12.7 2.2 7.0 12.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Amidase PF01425.21 EDN08624.1 - 2e-99 333.6 0.0 7e-99 331.8 0.0 1.7 1 1 0 1 1 1 1 Amidase Ldh_2 PF02615.14 EDN08625.1 - 1.4e-125 418.9 0.3 1.6e-125 418.7 0.3 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase DUF3402 PF11882.8 EDN08626.1 - 7.4e-189 628.6 0.0 9.6e-189 628.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EDN08626.1 - 3.4e-91 305.4 0.0 5.3e-91 304.8 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein Prok_Ub PF14454.6 EDN08626.1 - 0.0039 16.8 0.1 1 9.1 0.0 2.6 2 0 0 2 2 2 2 Prokaryotic Ubiquitin PAP2 PF01569.21 EDN08627.1 - 4.6e-11 42.6 7.7 5.8e-11 42.3 5.3 2.3 1 1 1 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EDN08627.1 - 0.00022 21.4 0.2 0.014 15.5 0.0 2.5 2 1 0 3 3 3 1 Divergent PAP2 family DUF4203 PF13886.6 EDN08627.1 - 0.027 14.1 3.2 0.38 10.4 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4203) Ost5 PF05251.12 EDN08627.1 - 0.17 12.2 2.4 0.34 11.2 1.4 2.0 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 CRT10 PF08728.10 EDN08629.1 - 1.8e-17 62.8 0.0 1.3e-08 33.6 0.0 2.3 2 0 0 2 2 2 2 CRT10 DNA_pol_phi PF04931.13 EDN08629.1 - 0.27 9.3 18.1 0.39 8.7 18.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EDN08629.1 - 7.1 5.9 11.6 12 5.2 11.6 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EDN08629.1 - 9.2 4.3 12.7 14 3.8 12.7 1.1 1 0 0 1 1 1 0 Nop14-like family Glyco_hydro_63 PF03200.16 EDN08630.1 - 3.6e-173 576.8 0.3 6.1e-172 572.8 0.3 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EDN08630.1 - 2.4e-67 227.3 0.2 1.8e-66 224.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EDN08630.1 - 0.04 12.8 1.9 0.26 10.1 0.1 2.3 1 1 0 2 2 2 0 Trehalase RVT_1 PF00078.27 EDN08631.1 - 3.7e-25 88.8 0.0 6.4e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN08631.1 - 1.8e-11 44.4 0.0 4.6e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN08631.1 - 2e-11 43.7 0.0 6.2e-11 42.2 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN08631.1 - 0.064 13.7 0.5 0.28 11.6 0.5 2.1 2 0 0 2 2 2 0 ORF 12 gene product N-terminal RVT_1 PF00078.27 EDN08633.1 - 2.8e-33 115.3 0.0 4.7e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN08633.1 - 2.3e-11 43.6 0.0 6.6e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN08633.1 - 9.9e-08 32.3 0.0 3.6e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN08633.1 - 0.064 13.7 0.7 0.29 11.6 0.5 2.2 2 0 0 2 2 2 0 ORF 12 gene product N-terminal DUF2321 PF10083.9 EDN08633.1 - 5.6 6.6 7.2 33 4.1 3.6 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) Vps51 PF08700.11 EDN08634.1 - 0.00078 19.5 0.1 0.0038 17.3 0.1 2.2 1 0 0 1 1 1 1 Vps51/Vps67 SesA PF17107.5 EDN08634.1 - 0.23 11.6 3.2 2.9 8.1 0.0 3.8 4 1 1 5 5 5 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DASH_Duo1 PF08651.10 EDN08634.1 - 1.8 8.4 4.7 46 3.9 0.1 4.0 4 0 0 4 4 4 0 DASH complex subunit Duo1 NDC10_II PF16787.5 EDN08635.1 - 1.5e-24 86.7 0.2 1.6e-10 40.5 0.5 3.1 2 1 1 3 3 3 3 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN08635.1 - 5.2e-17 61.9 0.6 1e-16 61.0 0.1 1.8 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes DUF3716 PF12511.8 EDN08635.1 - 0.017 15.1 0.1 0.038 14.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) RHS_repeat PF05593.14 EDN08635.1 - 0.08 13.5 0.3 0.4 11.2 0.0 2.4 3 0 0 3 3 3 0 RHS Repeat DUF1640 PF07798.11 EDN08636.1 - 7.5e-38 130.3 4.7 1e-37 129.8 4.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HIP1_clath_bdg PF16515.5 EDN08636.1 - 0.00022 21.8 5.0 0.00055 20.5 5.0 1.7 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Baculo_PEP_C PF04513.12 EDN08636.1 - 0.013 15.5 4.2 0.027 14.5 4.2 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Coat_F PF07875.12 EDN08636.1 - 0.16 12.2 0.6 0.5 10.6 0.6 1.8 1 0 0 1 1 1 0 Coat F domain ALMT PF11744.8 EDN08636.1 - 0.33 9.7 7.4 0.026 13.4 0.7 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter HEAT_2 PF13646.6 EDN08637.1 - 6.2e-08 32.9 0.1 0.071 13.5 0.0 5.5 4 1 1 5 5 5 4 HEAT repeats HEAT PF02985.22 EDN08637.1 - 6.4e-06 26.0 10.5 2.4 8.7 0.0 8.3 9 0 0 9 9 9 2 HEAT repeat Arm PF00514.23 EDN08637.1 - 0.028 14.5 1.8 1.7 8.8 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 EDN08637.1 - 0.036 14.7 0.0 5.2 7.7 0.0 3.9 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Transcrip_reg PF01709.20 EDN08638.1 - 2.5e-58 197.3 0.1 2.9e-58 197.1 0.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator CENP-I PF07778.11 EDN08639.1 - 4.6e-36 124.6 0.0 3.1e-35 121.9 0.0 1.9 1 1 0 1 1 1 1 Mis6 Luciferase_N PF05295.11 EDN08639.1 - 0.1 12.6 0.0 0.34 11.0 0.0 1.8 1 1 1 2 2 2 0 Luciferase/LBP N-terminal domain CLPTM1 PF05602.12 EDN08640.1 - 2.9e-158 527.4 0.0 3.5e-158 527.1 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) adh_short PF00106.25 EDN08641.1 - 3.6e-24 85.3 0.0 8.1e-24 84.2 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN08641.1 - 5.5e-15 55.6 0.0 1.2e-14 54.4 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN08641.1 - 0.034 14.1 0.0 0.15 11.9 0.0 2.1 2 1 0 2 2 2 0 KR domain ASXH PF13919.6 EDN08642.1 - 2.5e-39 134.5 1.1 4e-39 133.8 1.1 1.3 1 0 0 1 1 1 1 Asx homology domain Longin PF13774.6 EDN08643.1 - 2.1e-26 91.8 0.1 3.1e-26 91.2 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EDN08643.1 - 5.8e-13 48.4 0.0 1.4e-12 47.2 0.0 1.6 2 0 0 2 2 2 1 Synaptobrevin Elong_Iki1 PF10483.9 EDN08644.1 - 1.1e-72 245.1 2.1 8.7e-38 130.5 0.0 2.0 1 1 1 2 2 2 2 Elongator subunit Iki1 SNRNP27 PF08648.12 EDN08645.1 - 9.7e-26 89.6 1.9 2.4e-25 88.3 1.9 1.7 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins D123 PF07065.14 EDN08646.1 - 9e-115 383.0 0.0 1.1e-114 382.7 0.0 1.1 1 0 0 1 1 1 1 D123 ECH_1 PF00378.20 EDN08647.1 - 1.4e-25 90.1 0.0 1.8e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN08647.1 - 2.2e-20 73.4 0.0 2.5e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase HTH_7 PF02796.15 EDN08648.1 - 1.9e-07 31.0 0.0 5.1e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN08648.1 - 2.7e-06 27.0 0.0 0.00011 21.9 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EDN08648.1 - 5.8e-06 25.9 0.0 3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_29 PF13551.6 EDN08648.1 - 7.4e-06 25.9 0.0 5.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN08648.1 - 5.5e-05 22.8 0.0 0.00073 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN08648.1 - 0.00018 21.4 0.0 0.00029 20.8 0.0 1.3 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN08648.1 - 0.0071 16.9 0.0 1.2 9.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 EDN08648.1 - 0.036 13.6 0.5 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN08648.1 - 0.047 13.8 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN08648.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN08648.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein SDA1 PF05285.12 EDN08649.1 - 0.0032 16.9 12.4 0.0036 16.8 12.4 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 EDN08649.1 - 0.0061 14.9 12.4 0.0063 14.8 12.4 1.0 1 0 0 1 1 1 1 Nop14-like family SpoIIP PF07454.11 EDN08649.1 - 0.021 14.3 2.4 0.02 14.4 2.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CobT PF06213.12 EDN08649.1 - 0.028 13.8 13.4 0.037 13.4 13.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paf1 PF03985.13 EDN08649.1 - 0.033 13.2 12.9 0.042 12.9 12.9 1.2 1 0 0 1 1 1 0 Paf1 RPA43_OB PF17875.1 EDN08649.1 - 0.041 14.5 1.9 0.049 14.3 1.9 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I RPN2_C PF18004.1 EDN08649.1 - 0.044 13.7 10.5 0.066 13.1 10.5 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain BUD22 PF09073.10 EDN08649.1 - 0.05 13.0 11.1 0.044 13.1 11.1 1.1 1 0 0 1 1 1 0 BUD22 TRAP_alpha PF03896.16 EDN08649.1 - 0.059 12.6 9.8 0.078 12.2 9.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Usp PF00582.26 EDN08649.1 - 0.071 13.6 1.0 0.095 13.2 1.0 1.3 1 0 0 1 1 1 0 Universal stress protein family RNA_pol_Rpc4 PF05132.14 EDN08649.1 - 0.082 13.3 4.9 0.13 12.7 4.9 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 PTPRCAP PF15713.5 EDN08649.1 - 0.11 12.8 12.6 0.14 12.4 12.6 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4246 PF14033.6 EDN08649.1 - 0.12 11.5 2.4 0.13 11.3 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) POP1 PF06978.11 EDN08649.1 - 0.13 12.2 0.3 0.16 11.9 0.3 1.3 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 NOA36 PF06524.12 EDN08649.1 - 0.15 11.3 15.8 0.19 11.0 15.8 1.1 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 EDN08649.1 - 0.16 10.7 2.7 0.14 10.9 2.7 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 EDN08649.1 - 0.18 11.5 10.9 0.3 10.7 10.9 1.4 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EDN08649.1 - 0.19 10.0 11.3 0.22 9.8 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 EDN08649.1 - 0.2 11.4 1.2 0.2 11.4 1.2 1.1 1 0 0 1 1 1 0 Connexin Zip PF02535.22 EDN08649.1 - 0.23 10.7 1.2 0.19 10.9 1.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ORC_WH_C PF18137.1 EDN08649.1 - 0.25 11.4 6.0 0.45 10.6 6.0 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF3381 PF11861.8 EDN08649.1 - 0.3 10.9 14.3 38 4.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Tim54 PF11711.8 EDN08649.1 - 0.33 9.7 9.5 0.45 9.2 9.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNA_pol_3_Rpc31 PF11705.8 EDN08649.1 - 0.38 11.0 18.8 0.5 10.6 18.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.14 EDN08649.1 - 0.4 10.4 13.8 0.57 9.9 13.8 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RXT2_N PF08595.11 EDN08649.1 - 0.44 10.6 9.3 0.64 10.0 9.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal CPSF100_C PF13299.6 EDN08649.1 - 0.47 10.6 5.4 0.66 10.1 5.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PPP4R2 PF09184.11 EDN08649.1 - 0.52 9.8 17.2 0.73 9.4 17.2 1.2 1 0 0 1 1 1 0 PPP4R2 TFIIF_alpha PF05793.12 EDN08649.1 - 0.85 8.1 19.7 1 7.8 19.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RR_TM4-6 PF06459.12 EDN08649.1 - 0.9 9.3 10.3 1.2 8.9 10.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFB6 PF17110.5 EDN08649.1 - 1.2 8.8 7.4 1.6 8.4 7.4 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH GOLD_2 PF13897.6 EDN08649.1 - 1.3 9.5 5.3 2.2 8.8 5.3 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Sporozoite_P67 PF05642.11 EDN08649.1 - 1.4 6.9 7.8 1.7 6.6 7.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MAP17 PF15807.5 EDN08649.1 - 1.8 8.8 6.0 2.6 8.3 6.0 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4820 PF16091.5 EDN08649.1 - 2.3 7.5 7.3 3 7.1 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF913 PF06025.12 EDN08649.1 - 2.7 6.9 6.1 3.1 6.7 6.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RAB3GAP2_C PF14656.6 EDN08649.1 - 3 6.0 4.0 3.6 5.7 4.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus DUF4637 PF15470.6 EDN08649.1 - 3.3 7.4 17.4 5.6 6.7 17.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RRN3 PF05327.11 EDN08649.1 - 5.1 5.5 8.9 6 5.3 8.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4746 PF15928.5 EDN08649.1 - 5.5 6.3 20.7 0.22 10.9 14.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) NESP55 PF06390.12 EDN08649.1 - 6.5 6.3 26.4 0.2 11.2 3.0 2.3 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) V_ATPase_I PF01496.19 EDN08649.1 - 7.2 4.4 6.4 8.9 4.1 6.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Radial_spoke PF04712.12 EDN08649.1 - 8.5 5.2 19.1 12 4.7 19.1 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein Pet100 PF09803.9 EDN08650.1 - 1.4e-16 60.7 0.1 1.9e-16 60.4 0.1 1.2 1 0 0 1 1 1 1 Pet100 SPT_ssu-like PF11779.8 EDN08651.1 - 8.8e-24 82.9 4.1 1.3e-23 82.4 4.1 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like RF-1 PF00472.20 EDN08652.1 - 2.9e-22 78.8 6.6 2.9e-22 78.8 6.6 1.4 1 1 0 1 1 1 1 RF-1 domain Selenoprotein_S PF06936.11 EDN08652.1 - 0.032 14.0 7.4 0.042 13.7 7.4 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) CAS_CSE1 PF03378.15 EDN08653.1 - 3.1e-197 655.4 0.0 1.5e-196 653.2 0.0 2.1 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EDN08653.1 - 9e-144 478.8 7.8 4.4e-142 473.3 5.3 2.4 2 1 0 2 2 2 1 Cse1 IBN_N PF03810.19 EDN08653.1 - 8.4e-15 54.4 0.0 3.5e-14 52.5 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain Bromo_TP PF07524.13 EDN08653.1 - 0.11 12.5 0.1 28 4.8 0.0 2.9 2 0 0 2 2 2 0 Bromodomain associated DUF3384 PF11864.8 EDN08654.1 - 3.9e-102 342.6 6.5 6.7e-102 341.9 6.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EDN08654.1 - 6.5e-50 169.3 0.1 1.1e-49 168.5 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EDN08654.1 - 3.3e-25 89.0 5.0 3.1e-12 46.3 0.1 4.3 3 1 1 4 4 4 4 Tuberin RTP1_C1 PF10363.9 EDN08654.1 - 0.011 15.9 0.0 0.059 13.6 0.0 2.3 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 PUF PF00806.19 EDN08655.1 - 8.6e-45 148.0 4.4 4.2e-08 32.4 0.0 6.8 7 0 0 7 7 7 6 Pumilio-family RNA binding repeat Rif1_N PF12231.8 EDN08655.1 - 0.08 11.9 0.6 0.93 8.4 0.1 2.1 2 0 0 2 2 2 0 Rap1-interacting factor 1 N terminal sCache_2 PF17200.4 EDN08655.1 - 0.087 12.7 0.0 8.5 6.2 0.0 3.0 3 0 0 3 3 3 0 Single Cache domain 2 p450 PF00067.22 EDN08658.1 - 1.2e-20 73.8 0.0 1.5e-20 73.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4127 PF13552.6 EDN08658.1 - 0.087 11.4 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) p450 PF00067.22 EDN08659.1 - 2.9e-21 75.7 0.1 2.7e-20 72.6 0.1 1.9 1 1 0 1 1 1 1 Cytochrome P450 DUF4083 PF13314.6 EDN08662.1 - 0.0038 17.1 0.5 0.0074 16.2 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4083) DUF5326 PF17260.2 EDN08662.1 - 0.013 15.7 0.1 0.02 15.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5326) Stevor PF17410.2 EDN08662.1 - 0.21 11.1 0.0 0.27 10.7 0.0 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Phosphodiest PF01663.22 EDN08663.1 - 8.2e-15 55.2 0.2 1.7e-14 54.2 0.2 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDN08663.1 - 1.8e-05 24.3 0.1 2.7e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EDN08663.1 - 3.2e-05 23.4 0.6 5.5e-05 22.6 0.6 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Herpes_UL73 PF03554.13 EDN08663.1 - 8.3 6.5 6.6 3 7.9 1.5 2.5 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein cwf21 PF08312.12 EDN08664.1 - 1.7e-15 56.8 12.9 1.7e-15 56.8 12.9 1.8 2 0 0 2 2 2 1 cwf21 domain Spore_III_AF PF09581.10 EDN08664.1 - 0.14 12.2 0.7 0.23 11.4 0.7 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) HA2 PF04408.23 EDN08665.1 - 2.2e-14 53.6 0.4 2.2e-14 53.6 0.4 2.5 2 1 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDN08665.1 - 3e-12 46.9 0.1 2.3e-11 44.0 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN08665.1 - 4.3e-11 42.9 0.1 2.1e-09 37.4 0.1 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EDN08665.1 - 3.5e-10 40.1 0.0 8e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold ResIII PF04851.15 EDN08665.1 - 5.5e-05 23.2 0.0 0.46 10.5 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN08665.1 - 6.7e-05 23.2 0.0 0.00032 21.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDN08665.1 - 0.0006 19.6 0.0 0.0019 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN08665.1 - 0.00078 19.8 0.0 0.0017 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDN08665.1 - 0.01 14.9 0.0 0.023 13.8 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EDN08665.1 - 0.026 15.0 0.0 0.026 15.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EDN08665.1 - 0.029 13.7 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family HTH_7 PF02796.15 EDN08666.1 - 1.7e-07 31.2 0.0 4.5e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 EDN08666.1 - 2.1e-06 27.4 0.0 9.4e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EDN08666.1 - 5.2e-06 26.4 0.0 4.9e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_33 PF13592.6 EDN08666.1 - 6.2e-06 25.8 0.0 3.4e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 EDN08666.1 - 4.6e-05 23.1 0.0 0.00065 19.4 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 EDN08666.1 - 0.0007 19.5 0.0 0.0011 18.8 0.0 1.4 1 1 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 EDN08666.1 - 0.018 15.6 0.0 1 10.0 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain GerE PF00196.19 EDN08666.1 - 0.031 13.8 0.1 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EDN08666.1 - 0.038 14.1 0.0 3.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_5 PF06056.12 EDN08666.1 - 0.097 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 EDN08666.1 - 0.097 12.8 0.1 0.22 11.7 0.1 1.5 2 0 0 2 2 2 0 Trp repressor protein MARVEL PF01284.23 EDN08667.1 - 8.1e-14 51.9 14.6 1.2e-13 51.3 14.6 1.2 1 0 0 1 1 1 1 Membrane-associating domain FAM176 PF14851.6 EDN08667.1 - 0.014 15.1 0.6 0.023 14.4 0.6 1.4 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 EDN08667.1 - 0.063 12.5 0.6 0.082 12.1 0.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.12 EDN08667.1 - 1 8.7 6.8 1.3 8.3 6.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3682 PF12446.8 EDN08667.1 - 2.8 8.4 10.7 4.1 7.9 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) CDC45 PF02724.14 EDN08667.1 - 3.7 5.7 6.1 4.8 5.4 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Radial_spoke PF04712.12 EDN08667.1 - 9.7 5.0 11.0 13 4.6 11.0 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Cohesin_load PF10345.9 EDN08669.1 - 1.6e-185 618.1 14.0 2e-185 617.7 14.0 1.1 1 0 0 1 1 1 1 Cohesin loading factor TBCC_N PF16752.5 EDN08669.1 - 0.29 11.6 3.7 31 5.1 0.0 3.0 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Histone PF00125.24 EDN08670.1 - 1.1e-40 139.0 0.0 1.3e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EDN08670.1 - 0.00014 21.9 0.0 0.00021 21.4 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EDN08670.1 - 0.00044 20.6 0.1 0.00062 20.1 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EDN08670.1 - 0.021 15.1 0.6 0.037 14.3 0.6 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDN08670.1 - 0.15 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Tristanin_u2 PF16638.5 EDN08670.1 - 7.1 7.5 11.6 18 6.2 9.7 2.2 2 0 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers DER1 PF04511.15 EDN08671.1 - 1.8e-41 142.2 8.6 2.2e-41 141.9 8.6 1.1 1 0 0 1 1 1 1 Der1-like family Serpentine_r_xa PF03383.15 EDN08671.1 - 0.11 12.5 1.1 0.16 11.9 1.1 1.3 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa EMP70 PF02990.16 EDN08672.1 - 4.5e-174 580.0 0.0 5.6e-174 579.6 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 ubiquitin PF00240.23 EDN08673.1 - 1.5e-19 69.5 0.0 2.2e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDN08673.1 - 6.4e-05 22.7 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDN08673.1 - 0.00012 22.6 0.0 0.00022 21.7 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDN08673.1 - 0.0027 17.8 0.0 0.0047 17.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like GerD PF17898.1 EDN08673.1 - 0.011 15.7 3.4 0.019 14.9 3.4 1.3 1 0 0 1 1 1 0 Spore germination GerD central core domain STI1 PF17830.1 EDN08673.1 - 0.039 13.9 11.6 1.2 9.1 0.4 2.4 2 0 0 2 2 2 0 STI1 domain YukD PF08817.10 EDN08673.1 - 0.072 13.8 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD MMS1_N PF10433.9 EDN08674.1 - 8.5e-163 542.5 0.0 1.3e-162 541.9 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EDN08674.1 - 5.7e-101 338.0 0.0 5.5e-100 334.8 0.0 2.5 3 0 0 3 3 3 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 EDN08674.1 - 0.035 14.4 0.0 1.4 9.2 0.0 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CN_hydrolase PF00795.22 EDN08675.1 - 2.3e-23 82.9 0.0 2.3e-18 66.5 0.0 2.4 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase Neisseria_TspB PF05616.13 EDN08675.1 - 1 7.8 6.7 1.6 7.1 6.7 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein BP28CT PF08146.12 EDN08676.1 - 1.9e-40 138.3 0.5 7.6e-40 136.3 0.5 2.1 1 0 0 1 1 1 1 BP28CT (NUC211) domain HEAT_2 PF13646.6 EDN08676.1 - 0.00033 21.0 4.4 0.47 10.9 0.2 4.7 4 2 0 4 4 4 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EDN08676.1 - 0.12 13.0 0.0 17 6.1 0.0 3.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region U3snoRNP10 PF12397.8 EDN08677.1 - 2e-25 89.4 0.3 3.3e-24 85.5 0.0 2.6 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 EDN08677.1 - 0.0046 17.1 0.1 0.0046 17.1 0.1 3.4 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 EDN08677.1 - 0.017 15.5 0.0 0.059 13.8 0.0 1.9 1 0 0 1 1 1 0 HEAT repeats NRDE-2 PF08424.10 EDN08678.1 - 2.8e-69 233.7 3.2 6.4e-49 166.8 0.0 2.8 2 1 1 3 3 3 2 NRDE-2, necessary for RNA interference TPR_16 PF13432.6 EDN08678.1 - 0.032 14.9 0.0 17 6.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN08678.1 - 0.74 10.8 6.9 1.1 10.2 0.1 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat ZnuA PF01297.17 EDN08681.1 - 0.061 12.7 0.0 0.061 12.7 0.0 1.0 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic FAD_binding_8 PF08022.12 EDN08683.1 - 2.3e-22 79.1 0.0 4.4e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDN08683.1 - 3.9e-20 72.5 0.0 6.9e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDN08683.1 - 6e-19 68.4 10.8 6e-19 68.4 10.8 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component PIH1_CS PF18201.1 EDN08684.1 - 0.072 13.5 0.0 0.088 13.2 0.0 1.2 1 0 0 1 1 1 0 PIH1 CS-like domain SBDS PF01172.18 EDN08686.1 - 1.1e-23 83.1 0.1 1.3e-23 82.8 0.1 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein NIR_SIR PF01077.22 EDN08686.1 - 0.038 13.5 0.0 0.043 13.3 0.0 1.1 1 0 0 1 1 1 0 Nitrite and sulphite reductase 4Fe-4S domain NB-ARC PF00931.22 EDN08686.1 - 0.1 11.8 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain RhoGEF PF00621.20 EDN08687.1 - 5.9e-12 46.2 0.0 4.6e-05 23.7 0.1 2.4 1 1 1 2 2 2 2 RhoGEF domain WSN PF02206.18 EDN08687.1 - 0.15 12.0 0.0 0.5 10.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function Ras PF00071.22 EDN08688.1 - 8.8e-27 93.7 1.3 9.7e-21 74.0 0.1 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EDN08688.1 - 1.4e-10 41.4 1.6 0.00038 20.7 0.0 2.7 1 1 2 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EDN08688.1 - 0.0064 15.7 0.5 1.2 8.3 0.0 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Pox_A32 PF04665.12 EDN08688.1 - 0.0071 15.8 0.7 0.011 15.2 0.5 1.3 1 1 0 1 1 1 1 Poxvirus A32 protein ABC_tran PF00005.27 EDN08688.1 - 0.014 15.9 0.0 0.018 15.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EDN08688.1 - 0.022 14.5 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN08688.1 - 0.027 14.8 0.4 6 7.3 0.0 2.3 1 1 1 2 2 2 0 RNA helicase Arf PF00025.21 EDN08688.1 - 0.046 13.2 0.9 2.5 7.5 0.1 2.1 1 1 1 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDN08688.1 - 0.064 13.2 0.9 7.5 6.4 0.0 2.1 1 1 1 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 EDN08688.1 - 0.069 13.3 0.3 0.13 12.4 0.2 1.4 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EDN08688.1 - 0.094 12.7 0.2 0.16 12.0 0.2 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SNF2_N PF00176.23 EDN08689.1 - 1.3e-61 208.3 0.1 2.9e-61 207.2 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN08689.1 - 3.9e-15 56.2 0.0 1.2e-14 54.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN08689.1 - 1.4e-08 35.0 0.0 3.6e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EDN08689.1 - 3.6e-07 29.9 3.0 3.6e-07 29.9 3.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN08689.1 - 1.4e-06 28.1 5.3 2.7e-06 27.1 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN08689.1 - 0.00057 19.9 4.8 0.0012 18.8 4.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDN08689.1 - 0.00057 19.7 7.0 0.0014 18.4 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN08689.1 - 0.0018 18.6 7.0 0.0042 17.4 7.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDN08689.1 - 0.011 15.6 7.0 0.026 14.5 7.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EDN08689.1 - 0.021 14.7 5.9 0.075 12.9 5.9 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDN08689.1 - 0.29 11.3 9.1 0.63 10.2 9.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EDN08689.1 - 1 9.2 7.0 2.7 7.9 7.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SR-25 PF10500.9 EDN08690.1 - 0.13 11.8 15.1 0.17 11.4 10.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RSRP PF17069.5 EDN08690.1 - 0.24 10.9 15.6 0.4 10.2 15.6 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Med3 PF11593.8 EDN08690.1 - 0.33 10.1 0.0 0.33 10.1 0.0 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal AF-4 PF05110.13 EDN08690.1 - 7 4.6 15.7 0.65 8.0 10.1 2.0 3 0 0 3 3 3 0 AF-4 proto-oncoprotein SCP2 PF02036.17 EDN08691.1 - 2.6e-26 92.1 0.3 3e-26 91.9 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EDN08691.1 - 5.2e-09 36.5 0.1 6.3e-09 36.2 0.1 1.1 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 EDN08691.1 - 0.0014 19.0 0.0 0.0017 18.7 0.0 1.2 1 0 0 1 1 1 1 Sterol carrier protein domain uDENN PF03456.18 EDN08691.1 - 0.22 12.3 0.0 0.32 11.8 0.0 1.3 1 0 0 1 1 1 0 uDENN domain Ran_BP1 PF00638.18 EDN08692.1 - 6.1e-13 49.1 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Ribosomal_L31e PF01198.19 EDN08693.1 - 1.8e-40 137.1 0.4 2.2e-40 136.7 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e MS_channel PF00924.18 EDN08693.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel Mannosyl_trans3 PF11051.8 EDN08694.1 - 0.0017 17.7 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 EDN08694.1 - 0.76 9.3 3.4 27 4.2 3.4 2.1 1 1 0 1 1 1 0 Glycosyl transferase family 8 Aminotran_3 PF00202.21 EDN08695.1 - 5e-08 32.0 0.0 9.6e-08 31.1 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDN08695.1 - 0.012 14.8 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II DUF1748 PF08520.10 EDN08695.1 - 0.018 14.9 0.0 13 5.7 0.0 2.9 3 0 0 3 3 3 0 Fungal protein of unknown function (DUF1748) RNA_pol_Rpb2_2 PF04561.14 EDN08695.1 - 0.21 11.2 0.0 0.35 10.5 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 2 Tyrosinase PF00264.20 EDN08697.1 - 5e-42 144.7 1.0 1.3e-41 143.3 1.0 1.7 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EDN08697.1 - 5.6e-18 65.8 0.0 9.2e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Ank_2 PF12796.7 EDN08698.1 - 1.4e-11 44.8 0.3 2.4e-10 40.8 0.1 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EDN08698.1 - 1.8e-10 40.8 0.5 2.7e-05 24.4 0.3 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EDN08698.1 - 4.8e-09 36.3 0.2 2.9e-07 30.6 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN08698.1 - 1e-08 34.7 0.1 0.00034 20.8 0.1 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EDN08698.1 - 3.2e-08 33.9 0.0 1.2e-07 32.1 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDN08699.1 - 2.3e-20 72.9 0.0 7.9e-12 45.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EDN08699.1 - 9.6e-14 51.1 0.1 0.0016 18.8 0.0 4.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EDN08699.1 - 4e-12 46.1 0.0 1.6e-05 25.1 0.0 3.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN08699.1 - 8.9e-12 45.3 0.0 0.0054 17.3 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN08699.1 - 4.3e-11 42.0 0.0 0.0077 16.7 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat ADH_zinc_N PF00107.26 EDN08700.1 - 2.3e-14 53.5 0.2 4.1e-14 52.7 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Ecm29 PF13001.7 EDN08700.1 - 0.12 11.0 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Proteasome stabiliser ATG2_CAD PF13329.6 EDN08702.1 - 1.3e-46 158.2 0.4 3.8e-46 156.6 0.4 1.9 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EDN08702.1 - 3.1e-29 101.2 0.0 9.2e-29 99.7 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EDN08702.1 - 0.16 11.7 0.1 0.47 10.2 0.1 1.8 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal AMP-binding PF00501.28 EDN08703.1 - 1.7e-40 139.0 0.0 2.7e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme A_deaminase PF00962.22 EDN08703.1 - 1.6e-20 73.7 0.0 2.6e-20 73.0 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase AMP-binding_C PF13193.6 EDN08703.1 - 5e-20 72.3 0.6 6.3e-19 68.7 0.2 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain UQ_con PF00179.26 EDN08704.1 - 2.4e-49 166.6 0.0 2.9e-49 166.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN08704.1 - 7.1e-05 22.5 0.0 9.6e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDN08704.1 - 0.0016 18.3 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EDN08704.1 - 0.0021 18.3 0.1 0.0034 17.6 0.1 1.5 1 1 0 1 1 1 1 RWD domain Pkinase PF00069.25 EDN08705.1 - 7.7e-32 110.7 0.0 3.5e-31 108.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08705.1 - 3.5e-14 52.7 0.0 4.7e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN08705.1 - 2e-06 27.3 0.0 6e-06 25.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDN08705.1 - 0.00097 18.5 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN08705.1 - 0.099 12.5 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN08705.1 - 0.11 11.2 0.0 0.25 10.1 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 EDN08705.1 - 0.15 11.0 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDN08706.1 - 5.6e-08 33.0 0.1 1.2e-07 31.9 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN08706.1 - 4.8e-07 29.6 0.0 1.7e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 EDN08706.1 - 0.2 11.0 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DHBP_synthase PF00926.19 EDN08707.1 - 6.2e-78 260.7 0.0 7.1e-78 260.5 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase NatB_MDM20 PF09797.9 EDN08707.1 - 0.043 12.8 0.0 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit TFA2_Winged_2 PF18121.1 EDN08708.1 - 2e-23 81.8 0.6 4.5e-23 80.7 0.3 1.8 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EDN08708.1 - 1.2e-21 76.8 0.2 3.4e-21 75.3 0.0 1.9 2 0 0 2 2 2 1 TFIIE beta subunit core domain TPR_MLP1_2 PF07926.12 EDN08709.1 - 3.5e-38 130.6 31.1 3.5e-38 130.6 31.1 18.7 9 6 8 17 17 17 7 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EDN08709.1 - 0.00062 19.8 25.8 0.0013 18.8 6.5 15.6 6 4 8 15 15 15 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4472 PF14739.6 EDN08709.1 - 0.0052 17.5 1.7 0.0052 17.5 1.7 18.6 10 3 10 21 21 21 2 Domain of unknown function (DUF4472) LMBR1 PF04791.16 EDN08709.1 - 0.0054 15.7 0.1 0.0054 15.7 0.1 9.5 2 2 3 6 6 6 1 LMBR1-like membrane protein TMF_TATA_bd PF12325.8 EDN08709.1 - 0.0075 16.5 4.2 0.0075 16.5 4.2 20.2 6 5 13 19 19 19 1 TATA element modulatory factor 1 TATA binding Surfac_D-trimer PF09006.11 EDN08709.1 - 7.3 6.6 10.3 68 3.5 0.0 6.0 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation Hexapep PF00132.24 EDN08710.1 - 6.3e-09 35.2 12.6 6.6e-06 25.6 2.2 4.0 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDN08710.1 - 0.00047 19.8 5.0 0.14 11.9 1.4 3.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase LRR_6 PF13516.6 EDN08712.1 - 0.0029 17.5 0.8 25 5.2 0.0 4.0 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 EDN08712.1 - 0.039 14.4 0.0 1.1 9.8 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Sec63 PF02889.16 EDN08713.1 - 1.2e-21 77.0 0.0 3.7e-21 75.5 0.0 1.8 2 0 0 2 2 2 1 Sec63 Brl domain DEAD PF00270.29 EDN08713.1 - 1e-14 54.7 0.1 2.1e-14 53.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN08713.1 - 2.6e-07 31.0 0.0 1.2e-06 28.8 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN08713.1 - 6.2e-05 23.1 0.1 0.00014 21.9 0.1 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_5 PF14520.6 EDN08713.1 - 0.079 13.6 0.1 0.23 12.1 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain Nuc_sug_transp PF04142.15 EDN08715.1 - 1.6e-80 270.6 2.1 2e-80 270.3 2.1 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EDN08715.1 - 0.0017 18.5 9.9 0.0017 18.5 9.9 2.3 2 0 0 2 2 2 2 EamA-like transporter family Med3 PF11593.8 EDN08717.1 - 0.057 12.6 4.2 0.06 12.5 4.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Trs65 PF12735.7 EDN08717.1 - 0.09 12.2 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 HORMA PF02301.18 EDN08718.1 - 1.4e-52 178.4 0.7 2.3e-52 177.6 0.0 1.8 2 0 0 2 2 2 1 HORMA domain PHD PF00628.29 EDN08718.1 - 0.00011 22.0 6.7 0.00019 21.2 6.7 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EDN08718.1 - 0.018 14.6 2.7 0.079 12.5 2.9 1.9 1 1 1 2 2 2 0 PHD-finger Hormone_1 PF00103.20 EDN08718.1 - 0.086 12.6 0.1 2.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Somatotropin hormone family Rrf2 PF02082.20 EDN08718.1 - 0.12 12.8 0.9 0.28 11.5 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator WD40 PF00400.32 EDN08719.1 - 1.3e-40 136.6 19.4 1.7e-06 28.6 0.4 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box PF00646.33 EDN08719.1 - 5e-08 32.6 0.3 1.1e-07 31.5 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN08719.1 - 9.6e-08 31.8 0.1 2e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EDN08719.1 - 3.5e-06 27.2 1.9 3 8.2 0.1 5.4 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EDN08719.1 - 0.083 12.8 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 F-box Nup160 PF11715.8 EDN08719.1 - 0.16 10.6 3.9 5.1 5.6 0.0 4.0 3 1 2 5 5 5 0 Nucleoporin Nup120/160 MMR_HSR1 PF01926.23 EDN08720.1 - 1.6e-18 66.9 0.0 3.4e-18 65.8 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDN08720.1 - 1.6e-06 28.3 0.4 0.029 14.4 0.2 2.6 3 0 0 3 3 3 2 Dynamin family AIG1 PF04548.16 EDN08720.1 - 5.9e-05 22.5 0.0 8.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EDN08720.1 - 0.0011 18.9 0.8 0.0027 17.6 0.2 2.0 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EDN08720.1 - 0.003 17.1 0.0 0.039 13.5 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDN08720.1 - 0.0043 16.5 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDN08720.1 - 0.029 14.6 0.1 0.056 13.7 0.1 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EDN08720.1 - 0.03 13.8 0.0 0.052 13.1 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 EDN08720.1 - 0.044 13.5 0.0 0.095 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 EDN08720.1 - 0.085 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Septin Clat_adaptor_s PF01217.20 EDN08721.1 - 1.3e-38 132.2 0.0 2.3e-38 131.3 0.0 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_L7Ae PF01248.26 EDN08722.1 - 1.4e-21 76.0 0.4 1.4e-21 76.0 0.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDN08722.1 - 0.0081 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 CLPTM1 PF05602.12 EDN08722.1 - 0.027 13.5 0.2 0.034 13.2 0.2 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) HEAT_2 PF13646.6 EDN08723.1 - 4e-05 23.9 1.1 0.15 12.5 0.4 2.8 2 0 0 2 2 2 2 HEAT repeats CLASP_N PF12348.8 EDN08723.1 - 0.00022 20.9 0.1 0.0017 17.9 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal Cnd1 PF12717.7 EDN08723.1 - 0.00059 19.9 0.9 0.61 10.1 0.0 2.5 2 1 1 3 3 2 2 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 EDN08723.1 - 0.0059 16.2 0.6 0.029 14.0 0.3 2.4 1 1 1 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II ECH_2 PF16113.5 EDN08723.1 - 0.0068 15.9 0.6 0.0068 15.9 0.6 2.6 3 0 0 3 3 3 1 Enoyl-CoA hydratase/isomerase ERM PF00769.19 EDN08723.1 - 0.0085 15.9 16.3 0.031 14.1 8.0 2.6 3 0 0 3 3 2 2 Ezrin/radixin/moesin family TAN PF11640.8 EDN08723.1 - 0.009 16.2 0.3 0.009 16.2 0.3 2.7 2 1 0 2 2 2 1 Telomere-length maintenance and DNA damage repair Proteasom_PSMB PF10508.9 EDN08723.1 - 0.011 14.3 0.2 0.011 14.3 0.2 1.8 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.20 EDN08723.1 - 0.024 13.2 0.0 0.058 12.0 0.0 1.6 1 0 0 1 1 1 0 Adaptin N terminal region HEAT PF02985.22 EDN08723.1 - 0.046 14.0 1.1 1.7 9.1 0.2 3.7 4 0 0 4 4 4 0 HEAT repeat G-gamma PF00631.22 EDN08723.1 - 0.062 13.3 1.1 0.29 11.2 1.1 2.2 1 0 0 1 1 1 0 GGL domain V-ATPase_H_C PF11698.8 EDN08723.1 - 0.065 13.3 0.9 9.6 6.4 0.0 2.9 2 1 1 3 3 3 0 V-ATPase subunit H DUF3584 PF12128.8 EDN08723.1 - 0.14 9.6 8.1 0.3 8.6 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Golgin_A5 PF09787.9 EDN08723.1 - 0.18 11.2 13.5 0.47 9.9 13.5 1.6 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 EDN08723.1 - 0.23 10.8 14.2 1 8.6 7.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HAUS-augmin3 PF14932.6 EDN08723.1 - 0.84 9.2 16.0 2.7 7.5 12.2 2.5 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 Urb2 PF10441.9 EDN08723.1 - 2.6 7.9 4.3 11 5.9 0.1 2.6 2 1 1 3 3 3 0 Urb2/Npa2 family ADIP PF11559.8 EDN08723.1 - 3.7 7.6 14.8 13 5.9 14.8 1.9 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 EDN08723.1 - 6.5 5.7 8.6 13 4.7 8.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ING PF12998.7 EDN08723.1 - 6.7 7.4 9.4 1.3 9.7 4.5 2.3 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Peptidase_S46 PF10459.9 EDN08723.1 - 7.6 5.0 9.1 0.25 9.9 1.3 2.1 2 0 0 2 2 2 0 Peptidase S46 ENTH PF01417.20 EDN08724.1 - 4.9e-49 165.5 0.0 7.7e-49 164.9 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EDN08724.1 - 0.00014 21.0 0.0 0.00023 20.3 0.0 1.3 1 0 0 1 1 1 1 ANTH domain UIM PF02809.20 EDN08724.1 - 0.00024 20.8 8.3 0.012 15.4 1.8 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif DUF4264 PF14084.6 EDN08724.1 - 0.036 13.7 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) Chorismate_bind PF00425.18 EDN08725.1 - 2.9e-91 305.6 0.0 4.1e-91 305.1 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EDN08725.1 - 2.8e-25 89.2 0.3 2e-20 73.5 0.1 4.1 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region Cep57_MT_bd PF06657.13 EDN08726.1 - 0.45 11.0 3.6 0.43 11.1 0.3 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 ANAPC4_WD40 PF12894.7 EDN08727.1 - 0.00012 22.4 0.0 8.7 6.7 0.0 5.3 5 2 2 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EDN08727.1 - 0.0051 16.7 0.1 0.015 15.2 0.1 1.8 1 0 0 1 1 1 1 LisH WD40 PF00400.32 EDN08727.1 - 0.022 15.6 0.1 0.022 15.6 0.1 5.6 6 1 0 6 6 6 0 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EDN08727.1 - 0.06 12.3 1.8 2.3 7.1 0.0 2.8 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ATP-grasp_5 PF13549.6 EDN08727.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain DUF1751 PF08551.10 EDN08728.1 - 1.2e-27 96.4 3.9 2.2e-27 95.5 3.9 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EDN08728.1 - 0.00082 19.4 7.1 0.0014 18.6 7.1 1.3 1 0 0 1 1 1 1 Rhomboid family S19 PF06756.11 EDN08728.1 - 0.018 15.0 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 Chorion protein S19 C-terminal DUF4149 PF13664.6 EDN08728.1 - 0.23 11.8 4.3 0.28 11.5 0.8 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4149) L51_S25_CI-B8 PF05047.16 EDN08729.1 - 6.3e-15 54.8 0.0 9.9e-15 54.2 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Med30 PF11315.8 EDN08729.1 - 0.041 14.1 1.2 0.07 13.3 1.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 CRF PF00473.17 EDN08729.1 - 2.1 8.5 5.6 6.4 6.9 0.3 2.4 2 0 0 2 2 2 0 Corticotropin-releasing factor family tRNA-synt_1 PF00133.22 EDN08730.1 - 9e-34 116.7 0.0 2.4e-23 82.3 0.0 3.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDN08730.1 - 3.7e-15 55.6 0.3 1.6e-09 37.0 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDN08730.1 - 3.1e-11 43.4 0.1 6e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EDN08730.1 - 5.2e-08 32.6 0.0 9.4e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EDN08730.1 - 0.11 11.4 0.0 0.31 9.9 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (K) Sde2_N_Ubi PF13019.6 EDN08731.1 - 4.7e-12 46.0 4.4 9.2e-12 45.1 4.4 1.5 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain S10_plectin PF03501.15 EDN08732.1 - 1.5e-41 140.4 0.1 1.8e-41 140.1 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Peptidase_M20 PF01546.28 EDN08733.1 - 1.6e-07 31.3 0.0 1.7e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 AAA PF00004.29 EDN08734.1 - 6.3e-08 33.1 0.1 1.8e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.25 EDN08736.1 - 5.7e-19 68.5 0.0 8e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08736.1 - 5.5e-08 32.4 0.0 7.4e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDN08736.1 - 0.0085 15.5 0.4 0.05 12.9 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDN08737.1 - 5.7e-37 127.5 0.0 3e-29 102.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08737.1 - 3.7e-13 49.3 0.0 3.1e-11 43.1 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EDN08737.1 - 1.2e-05 24.7 0.0 0.003 16.9 0.0 2.5 2 1 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDN08737.1 - 0.00039 19.8 0.0 0.00097 18.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDN08737.1 - 0.027 13.2 0.0 0.11 11.2 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EDN08737.1 - 0.033 14.1 0.0 8.4 6.2 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EDN08737.1 - 0.041 12.8 0.0 6.7 5.6 0.0 2.2 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 EDN08737.1 - 0.094 12.3 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF2205 PF10224.9 EDN08739.1 - 0.0022 18.0 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 Short coiled-coil protein CRAL_TRIO PF00650.20 EDN08740.1 - 8.9e-29 100.3 0.1 5.9e-28 97.6 0.1 2.1 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDN08740.1 - 4.2e-14 52.5 0.3 1.4e-13 50.7 0.3 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDN08740.1 - 2.4e-05 24.5 0.0 6.8e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Kringle PF00051.18 EDN08740.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Kringle domain DASH_Dam1 PF08653.10 EDN08741.1 - 1e-30 105.2 2.9 1.4e-30 104.8 2.9 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 UCH PF00443.29 EDN08743.1 - 1.1e-30 107.0 2.2 4.4e-28 98.5 2.2 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN08743.1 - 2e-14 53.9 6.1 5.2e-10 39.4 0.1 2.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDN08743.1 - 1.3e-06 28.7 0.3 1.3e-06 28.7 0.3 3.3 3 1 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Ytp1 PF10355.9 EDN08744.1 - 2e-118 394.6 6.7 3.4e-118 393.9 6.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EDN08744.1 - 1.2e-17 63.6 12.0 1.6e-09 37.5 0.6 3.8 2 1 1 3 3 3 3 Domain of unknown function (DUF2427) OTT_1508_deam PF14441.6 EDN08745.1 - 1e-11 44.6 0.1 2.2e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase PMC2NT PF08066.12 EDN08745.1 - 0.12 13.1 0.2 0.87 10.3 0.0 2.3 2 1 0 2 2 2 0 PMC2NT (NUC016) domain Rhomboid PF01694.22 EDN08746.1 - 0.001 19.1 1.2 0.0012 18.9 1.2 1.1 1 0 0 1 1 1 1 Rhomboid family Gaa1 PF04114.14 EDN08747.1 - 4e-173 577.0 6.7 5.2e-173 576.6 6.7 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 EDN08748.1 - 5e-10 39.8 0.0 9.2e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EDN08748.1 - 1.4e-05 24.6 0.2 3e-05 23.5 0.2 1.6 1 0 0 1 1 1 1 Rpn9 C-terminal helix DUF1027 PF06265.11 EDN08748.1 - 0.058 13.4 0.1 0.41 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) Epimerase PF01370.21 EDN08749.1 - 1.2e-14 54.3 0.0 2.1e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDN08749.1 - 8.8e-13 48.6 0.0 1.4e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDN08749.1 - 1.5e-12 47.6 0.0 2.1e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EDN08749.1 - 1.8e-10 40.3 0.0 3.2e-10 39.5 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDN08749.1 - 3.9e-08 33.1 0.2 1e-07 31.7 0.1 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EDN08749.1 - 2.5e-06 26.8 0.0 3.2e-05 23.2 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EDN08749.1 - 4.9e-05 22.9 0.0 9.3e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EDN08749.1 - 0.00065 18.9 0.1 0.04 13.1 0.0 2.6 1 1 1 3 3 3 1 Male sterility protein adh_short_C2 PF13561.6 EDN08749.1 - 0.0055 16.3 0.0 0.0095 15.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN08749.1 - 0.0082 16.1 0.0 1.9 8.4 0.0 2.6 3 0 0 3 3 3 1 KR domain NAD_synthase PF02540.17 EDN08749.1 - 0.023 13.8 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD synthase HIM1 PF08732.10 EDN08749.1 - 0.043 13.3 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 HIM1 HEM4 PF02602.15 EDN08750.1 - 4e-25 88.5 0.0 3.9e-16 59.1 0.0 2.0 2 0 0 2 2 2 2 Uroporphyrinogen-III synthase HemD Pkinase PF00069.25 EDN08751.1 - 3.8e-67 226.4 0.0 4.7e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08751.1 - 2.7e-32 112.1 0.0 3.4e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDN08751.1 - 0.0004 19.8 0.2 0.00064 19.1 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDN08751.1 - 0.0026 16.8 0.4 0.0052 15.8 0.4 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDN08751.1 - 0.0092 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDN08751.1 - 0.036 14.0 0.1 0.058 13.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDN08751.1 - 0.069 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Sec23_trunk PF04811.15 EDN08753.1 - 1.8e-70 237.3 0.0 3.2e-70 236.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDN08753.1 - 7.7e-24 83.5 0.0 3e-23 81.6 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDN08753.1 - 2.8e-17 63.2 0.0 5.6e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EDN08753.1 - 1.7e-16 60.0 4.5 3e-16 59.2 4.5 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDN08753.1 - 4.5e-08 32.9 0.0 1.2e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EDN08753.1 - 0.12 11.8 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Hemerythrin PF01814.23 EDN08754.1 - 4e-12 46.9 2.5 5.8e-12 46.4 2.5 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain CTK3_C PF12350.8 EDN08754.1 - 0.16 12.1 8.1 0.081 13.1 5.3 1.9 2 1 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus adh_short PF00106.25 EDN08755.1 - 9e-09 35.1 0.2 1.2e-08 34.6 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN08755.1 - 6.2e-08 32.5 0.3 9e-08 31.9 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Exotox-A_bind PF09101.10 EDN08755.1 - 0.065 12.6 0.0 0.14 11.5 0.0 1.5 2 0 0 2 2 2 0 Exotoxin A binding Kinesin PF00225.23 EDN08756.1 - 5.1e-82 275.5 0.8 7.6e-82 274.9 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDN08756.1 - 4.4e-20 72.1 0.0 1.3e-19 70.6 0.0 1.8 1 1 0 1 1 1 1 Microtubule binding HHH PF00633.23 EDN08756.1 - 4.3e-07 29.5 0.9 0.015 15.1 0.0 3.4 3 0 0 3 3 3 2 Helix-hairpin-helix motif HHH_3 PF12836.7 EDN08756.1 - 0.0015 18.8 0.1 2 8.7 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.6 EDN08756.1 - 0.012 16.2 0.1 2.6 8.7 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain MFS_1 PF07690.16 EDN08757.1 - 1.1e-29 103.5 50.8 3.9e-18 65.5 23.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2304 PF10066.9 EDN08757.1 - 5.9 7.2 10.7 25 5.1 0.4 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) AIM24 PF01987.17 EDN08759.1 - 2e-05 24.5 0.0 4.5e-05 23.3 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial biogenesis AIM24 ABC_membrane PF00664.23 EDN08760.1 - 5.5e-41 141.0 8.0 7.8e-41 140.5 8.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDN08760.1 - 2.1e-33 115.7 0.0 4.2e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDN08760.1 - 1.1e-05 25.0 0.1 0.007 15.8 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDN08760.1 - 0.00058 20.3 0.0 0.0015 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EDN08760.1 - 0.00083 19.2 0.2 0.018 14.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDN08760.1 - 0.00088 19.6 0.0 0.0032 17.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDN08760.1 - 0.0093 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EDN08760.1 - 0.013 16.0 0.0 0.037 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EDN08760.1 - 0.029 14.3 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_14 PF13173.6 EDN08760.1 - 0.044 13.8 0.0 0.57 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDN08760.1 - 0.078 13.2 0.0 0.41 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN08760.1 - 0.081 12.6 0.0 0.37 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EDN08760.1 - 0.09 13.2 0.0 0.67 10.4 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.25 EDN08760.1 - 0.09 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 EDN08760.1 - 0.097 12.8 0.0 0.4 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EDN08760.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_ATPase PF09818.9 EDN08760.1 - 0.15 10.8 0.0 1.4 7.6 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Vac14_Fig4_bd PF11916.8 EDN08762.1 - 1.7e-54 184.2 10.0 6.1e-30 104.2 2.1 2.9 2 1 1 3 3 3 2 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EDN08762.1 - 9e-43 144.8 0.0 2.4e-40 137.0 0.0 3.7 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDN08762.1 - 2.1e-10 40.8 0.5 0.02 15.4 0.0 5.8 4 1 1 5 5 5 2 HEAT-like repeat HEAT PF02985.22 EDN08762.1 - 3.8e-09 36.0 0.5 0.0018 18.4 0.0 5.9 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EDN08762.1 - 7.3e-05 22.9 1.1 0.15 12.1 0.2 3.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDN08762.1 - 0.00072 19.9 0.8 2 8.9 0.0 4.7 5 0 0 5 5 5 1 HEAT repeats Arm PF00514.23 EDN08762.1 - 0.01 15.8 0.0 12 6.1 0.0 4.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EDN08762.1 - 0.021 14.4 0.1 4.9 6.6 0.0 4.0 4 2 2 6 6 6 0 CLASP N terminal WLM PF08325.10 EDN08762.1 - 0.067 13.3 0.0 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 WLM domain Dopey_N PF04118.14 EDN08762.1 - 0.096 11.8 0.5 15 4.6 0.0 3.6 4 0 0 4 4 4 0 Dopey, N-terminal SNF2_N PF00176.23 EDN08763.1 - 2.7e-56 190.8 0.0 4.1e-56 190.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EDN08763.1 - 1.5e-21 77.3 0.1 3.3e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.31 EDN08763.1 - 1.3e-14 54.5 0.0 2.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN08763.1 - 0.14 12.2 0.0 0.44 10.5 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Mito_carr PF00153.27 EDN08764.1 - 8.4e-49 163.5 6.2 1.7e-20 72.7 0.2 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein zf-C2H2_jaz PF12171.8 EDN08765.1 - 4.4e-10 39.6 1.6 4.4e-10 39.6 1.6 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 EDN08765.1 - 0.0073 16.1 0.3 0.015 15.0 0.3 1.5 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_2 PF12756.7 EDN08765.1 - 0.017 15.5 0.7 0.027 14.8 0.7 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Tna_leader PF08053.11 EDN08765.1 - 0.042 13.8 0.1 0.074 13.0 0.1 1.4 1 0 0 1 1 1 0 Tryptophanase operon leader peptide zf-C2H2_4 PF13894.6 EDN08765.1 - 0.24 12.4 0.6 0.24 12.4 0.6 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Aconitase PF00330.20 EDN08767.1 - 3.9e-136 454.7 0.0 4.4e-135 451.2 0.0 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDN08767.1 - 6.2e-45 152.7 0.0 1e-44 152.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Lactamase_B PF00753.27 EDN08768.1 - 2.7e-19 70.0 3.0 4.7e-17 62.7 3.0 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EDN08768.1 - 3e-16 59.1 0.0 8.7e-16 57.6 0.0 1.9 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EDN08768.1 - 3.8e-06 26.6 0.3 7.4e-06 25.6 0.3 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDN08768.1 - 0.042 13.8 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Glyco_transf_20 PF00982.21 EDN08769.1 - 6.1e-201 668.2 0.0 7e-201 668.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 EDN08769.1 - 0.00055 20.4 0.0 0.0012 19.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EDN08769.1 - 0.011 15.4 0.1 0.036 13.8 0.0 1.8 2 0 0 2 2 2 0 Starch synthase catalytic domain Cas_CT1975 PF09344.10 EDN08769.1 - 0.15 11.5 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 CT1975-like protein Ribosomal_S17 PF00366.20 EDN08770.1 - 4.7e-14 52.3 0.6 7.7e-14 51.6 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 AAA PF00004.29 EDN08771.1 - 5.3e-37 127.2 0.0 1.2e-36 126.0 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDN08771.1 - 1.8e-10 40.7 0.0 1e-07 31.8 0.0 3.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EDN08771.1 - 1.3e-07 31.3 0.0 3.1e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDN08771.1 - 2e-05 24.9 0.2 0.00031 21.0 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EDN08771.1 - 5.4e-05 23.4 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDN08771.1 - 0.00014 21.6 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDN08771.1 - 0.00076 19.9 0.6 0.013 15.9 0.1 2.6 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EDN08771.1 - 0.0013 18.8 0.1 0.0063 16.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDN08771.1 - 0.0058 16.0 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EDN08771.1 - 0.014 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 EDN08771.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EDN08771.1 - 0.021 15.0 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDN08771.1 - 0.037 14.0 0.0 0.077 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDN08771.1 - 0.038 13.6 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDN08771.1 - 0.044 13.7 0.1 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 EDN08771.1 - 0.067 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EDN08771.1 - 0.078 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDN08771.1 - 0.13 11.6 0.0 4 6.8 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein DUF815 PF05673.13 EDN08771.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mito_carr PF00153.27 EDN08772.1 - 4.2e-59 196.5 2.8 2.6e-20 72.1 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDN08772.1 - 0.054 12.7 0.4 0.37 9.9 0.1 2.1 1 1 1 2 2 2 0 Gammaproteobacterial serine protease 3Beta_HSD PF01073.19 EDN08773.1 - 8.1e-57 192.3 0.0 1.3e-56 191.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDN08773.1 - 6.9e-27 94.4 0.1 9.8e-27 94.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDN08773.1 - 4.2e-17 62.6 0.1 2.9e-14 53.2 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDN08773.1 - 9.1e-12 44.7 0.9 7.3e-10 38.4 0.1 2.1 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EDN08773.1 - 2.6e-08 33.3 0.0 3.4e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDN08773.1 - 3e-06 26.6 1.4 2.7e-05 23.5 0.9 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EDN08773.1 - 1.1e-05 25.4 0.0 2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EDN08773.1 - 0.00031 20.7 1.5 0.01 15.8 1.5 2.3 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EDN08773.1 - 0.032 13.7 0.0 0.074 12.5 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase Mog1 PF04603.12 EDN08774.1 - 2.7e-25 89.3 0.1 6.7e-25 88.1 0.1 1.7 1 0 0 1 1 1 1 Ran-interacting Mog1 protein IBR PF01485.21 EDN08774.1 - 8.1e-21 74.0 49.4 1.4e-11 44.4 6.2 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EDN08774.1 - 7.9e-05 22.4 40.6 0.00069 19.4 5.1 4.4 3 1 1 4 4 4 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN08774.1 - 0.002 18.4 7.9 0.002 18.4 7.9 3.9 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDN08774.1 - 0.003 17.3 4.9 0.003 17.3 4.9 4.8 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) UN_NPL4 PF11543.8 EDN08774.1 - 0.0031 18.0 0.1 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 zf-C3HC4_4 PF15227.6 EDN08774.1 - 0.12 12.6 25.5 0.071 13.3 0.6 4.2 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDN08774.1 - 1.2 9.2 36.7 0.058 13.4 5.1 4.0 3 1 0 3 3 3 0 RING-type zinc-finger NYN PF01936.18 EDN08775.1 - 0.00056 20.4 0.0 0.0012 19.4 0.0 1.7 1 1 0 1 1 1 1 NYN domain HSP9_HSP12 PF04119.12 EDN08776.1 - 2.5e-29 101.4 7.0 2.5e-29 101.4 7.0 2.1 2 0 0 2 2 2 1 Heat shock protein 9/12 YtxH PF12732.7 EDN08776.1 - 0.01 16.3 3.3 0.016 15.8 2.7 1.7 1 1 0 1 1 1 0 YtxH-like protein ISG65-75 PF11727.8 EDN08776.1 - 0.027 13.7 2.3 0.03 13.6 2.3 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein GAGBD PF16828.5 EDN08777.1 - 0.00021 21.4 0.4 0.00045 20.3 0.1 1.6 1 1 1 2 2 2 1 GAG-binding domain on surface antigen Snapin_Pallidin PF14712.6 EDN08777.1 - 0.023 15.1 1.5 0.11 13.0 0.2 2.7 2 1 0 2 2 2 0 Snapin/Pallidin Nsp1_C PF05064.13 EDN08777.1 - 0.11 12.4 2.1 0.53 10.1 0.3 2.3 2 0 0 2 2 2 0 Nsp1-like C-terminal region Spc24 PF08286.11 EDN08777.1 - 0.12 12.6 3.6 0.16 12.2 1.7 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Arm-DNA-bind_5 PF17293.2 EDN08777.1 - 0.18 12.3 2.1 0.54 10.7 0.3 2.3 2 0 0 2 2 2 0 Arm DNA-binding domain APG6_N PF17675.1 EDN08777.1 - 0.23 12.0 13.2 0.27 11.8 8.6 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region COG6 PF06419.11 EDN08778.1 - 9.6e-196 651.7 0.0 1.2e-195 651.5 0.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 NIF3 PF01784.18 EDN08779.1 - 6.1e-52 176.7 0.0 8.2e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.18 EDN08780.1 - 9.4e-19 67.5 0.0 2.4e-18 66.2 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein Redoxin PF08534.10 EDN08781.1 - 2.8e-27 95.2 0.0 3.5e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin HSF_DNA-bind PF00447.17 EDN08783.1 - 1.7e-27 95.9 1.4 1.7e-27 95.9 1.4 1.9 2 0 0 2 2 2 1 HSF-type DNA-binding YabA PF06156.13 EDN08783.1 - 0.29 11.8 5.9 0.56 10.9 5.6 1.8 1 1 0 1 1 1 0 Initiation control protein YabA bZIP_1 PF00170.21 EDN08783.1 - 3.3 7.9 5.8 0.58 10.3 0.3 2.5 2 1 1 3 3 3 0 bZIP transcription factor Hexapep PF00132.24 EDN08784.1 - 2.2e-10 39.8 17.2 0.00016 21.2 4.0 4.3 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) W2 PF02020.18 EDN08784.1 - 8.5e-10 38.6 0.8 8.5e-10 38.6 0.8 2.0 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep_2 PF14602.6 EDN08784.1 - 0.0046 16.7 13.6 0.044 13.6 3.5 4.1 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EDN08784.1 - 0.027 12.6 1.4 0.092 10.9 0.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4954) SprT-like PF10263.9 EDN08785.1 - 8.3e-48 161.0 0.2 2.2e-47 159.6 0.2 1.8 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 EDN08785.1 - 2.1e-10 40.3 6.9 4.6e-10 39.2 6.9 1.6 1 0 0 1 1 1 1 SprT-like zinc ribbon domain DUF1223 PF06764.11 EDN08785.1 - 0.13 12.3 0.8 0.44 10.5 0.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) DUF4379 PF14311.6 EDN08785.1 - 1.3 9.5 6.9 0.74 10.2 3.9 2.2 2 0 0 2 2 2 0 Probable Zinc-ribbon domain SDP_N PF12278.8 EDN08785.1 - 2 8.5 4.3 4.5 7.4 0.1 3.0 2 0 0 2 2 2 0 Sex determination protein N terminal Glyco_hydro_72 PF03198.14 EDN08786.1 - 4.3e-131 436.8 7.7 5.5e-131 436.5 7.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EDN08786.1 - 2e-25 89.3 1.4 7.9e-25 87.3 1.4 2.1 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.15 EDN08790.1 - 0 1385.5 0.0 0 1385.0 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDN08790.1 - 5.9e-44 149.5 1.2 2e-43 147.8 1.2 2.0 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Aminotran_1_2 PF00155.21 EDN08791.1 - 2.8e-30 105.7 0.0 3.4e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDN08791.1 - 0.056 12.0 0.0 0.13 10.7 0.0 1.5 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Glyco_hydro_17 PF00332.18 EDN08792.1 - 1.3e-07 31.5 0.3 4e-07 29.9 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 p450 PF00067.22 EDN08793.1 - 7.8e-11 41.4 0.0 6.9e-05 21.8 0.1 2.1 2 0 0 2 2 2 2 Cytochrome P450 DUF2013 PF09431.10 EDN08794.1 - 2.1e-52 176.9 0.6 3.7e-52 176.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) DUF3470 PF11953.8 EDN08794.1 - 0.85 9.6 3.4 5.4 7.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3470) Glyco_hydro_47 PF01532.20 EDN08795.1 - 7.8e-195 648.1 0.0 9.2e-195 647.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 EDN08795.1 - 0.11 11.8 0.0 0.52 9.5 0.0 1.9 2 0 0 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) APG9 PF04109.16 EDN08796.1 - 2e-193 643.8 10.3 1.5e-173 578.2 2.6 2.0 1 1 1 2 2 2 2 Autophagy protein Apg9 RasGAP PF00616.19 EDN08797.1 - 3.4e-32 111.8 0.0 3.9e-22 79.0 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EDN08797.1 - 0.0031 17.8 0.0 0.012 15.8 0.0 2.0 1 1 0 1 1 1 1 C2 domain Tropomyosin PF00261.20 EDN08797.1 - 0.18 11.2 0.2 0.38 10.1 0.2 1.5 1 0 0 1 1 1 0 Tropomyosin DUF1803 PF08820.10 EDN08799.1 - 0.00078 19.4 0.2 0.0019 18.2 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1803) NUDE_C PF04880.13 EDN08800.1 - 1.1 9.7 7.7 2.4 8.6 7.7 1.5 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region WD40 PF00400.32 EDN08801.1 - 2.4e-07 31.3 1.5 8.4 7.5 0.0 5.4 6 0 0 6 6 6 4 WD domain, G-beta repeat PQQ_3 PF13570.6 EDN08801.1 - 0.037 14.5 0.1 0.27 11.8 0.0 2.5 2 0 0 2 2 2 0 PQQ-like domain COQ9 PF08511.11 EDN08803.1 - 7.4e-24 83.3 0.2 1.3e-23 82.5 0.2 1.4 1 0 0 1 1 1 1 COQ9 DUF2976 PF11190.8 EDN08803.1 - 0.072 12.9 0.8 0.18 11.6 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) AA_permease_2 PF13520.6 EDN08804.1 - 1.5e-26 93.2 11.8 1.5e-26 93.2 11.8 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EDN08804.1 - 4.4e-18 65.1 11.9 4.4e-18 65.1 11.9 2.0 2 0 0 2 2 2 1 Amino acid permease FmdA_AmdA PF03069.15 EDN08805.1 - 2.6e-56 191.1 0.0 2.4e-31 108.9 0.0 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family RRM_1 PF00076.22 EDN08807.1 - 3.7e-36 122.8 0.0 6.4e-17 61.1 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDN08807.1 - 0.029 14.4 1.1 6.1 7.0 0.1 3.5 3 1 0 3 3 3 0 Limkain b1 ATP-grasp_2 PF08442.10 EDN08807.1 - 0.09 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain RRM_Rrp7 PF17799.1 EDN08807.1 - 0.19 11.5 0.0 18 5.1 0.0 2.8 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain GRP PF07172.11 EDN08807.1 - 7.8 7.3 51.0 4.8 7.9 32.9 3.6 3 0 0 3 3 3 0 Glycine rich protein family TrkH PF02386.16 EDN08808.1 - 1.9e-116 389.5 5.8 2e-77 260.8 4.6 2.1 1 1 1 2 2 2 2 Cation transport protein PH PF00169.29 EDN08809.1 - 2.7e-05 24.6 0.2 7.7e-05 23.2 0.1 1.9 2 0 0 2 2 2 1 PH domain Tim17 PF02466.19 EDN08810.1 - 6.6e-07 29.7 7.5 7.8e-07 29.5 6.5 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family RPT PF13446.6 EDN08811.1 - 1.7e-51 171.9 0.7 8.9e-19 67.2 0.4 4.5 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH PF00443.29 EDN08811.1 - 1.2e-44 152.7 0.0 3.5e-44 151.2 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN08811.1 - 0.00077 19.1 5.0 0.0054 16.4 5.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CoA_trans PF01144.23 EDN08812.1 - 1.1e-60 204.7 1.9 6.7e-33 113.9 0.3 4.0 3 1 0 3 3 3 3 Coenzyme A transferase Methyltransf_21 PF05050.12 EDN08812.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase FkbM domain DUF2370 PF10176.9 EDN08813.1 - 2.9e-91 305.1 0.0 5.1e-91 304.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) WSC PF01822.19 EDN08814.1 - 3.1e-12 46.5 7.7 3.1e-12 46.5 7.7 1.6 2 0 0 2 2 2 1 WSC domain SKG6 PF08693.10 EDN08814.1 - 5.3e-05 22.5 0.7 5.3e-05 22.5 0.7 2.1 2 0 0 2 2 2 1 Transmembrane alpha-helix domain MGC-24 PF05283.11 EDN08814.1 - 0.13 12.7 2.6 0.23 11.9 2.6 1.5 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin LapA_dom PF06305.11 EDN08814.1 - 0.17 11.7 0.2 1.7 8.5 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain CDP-OH_P_transf PF01066.21 EDN08815.1 - 1.6e-11 44.8 0.6 4.2e-11 43.4 0.1 1.9 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Gar1 PF04410.14 EDN08816.1 - 1.3e-14 54.3 0.0 1.6e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region tRNA-synt_2b PF00587.25 EDN08817.1 - 2.7e-15 56.8 0.0 3.6e-11 43.4 0.0 3.5 2 1 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDN08817.1 - 2.3e-14 53.3 0.1 5e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EDN08817.1 - 5.6e-12 45.6 0.0 1.1e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EDN08817.1 - 0.00053 20.0 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 TGS domain Fungal_trans PF04082.18 EDN08818.1 - 9e-20 70.8 0.3 6.5e-19 68.0 0.0 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN08818.1 - 8.8e-10 38.5 13.1 1.5e-09 37.8 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M41 PF01434.18 EDN08819.1 - 7.3e-67 224.9 0.0 1.2e-66 224.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDN08819.1 - 4.4e-42 143.6 0.0 9.3e-42 142.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN08819.1 - 3.2e-13 49.3 0.1 7.7e-13 48.0 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EDN08819.1 - 4e-08 33.6 0.1 1.2e-07 32.1 0.1 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 EDN08819.1 - 0.00035 20.6 0.1 0.01 15.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN08819.1 - 0.0037 17.6 0.3 1.2 9.4 0.1 3.2 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 EDN08819.1 - 0.0043 17.5 0.0 0.15 12.4 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDN08819.1 - 0.0044 16.8 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDN08819.1 - 0.011 15.0 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_2 PF07724.14 EDN08819.1 - 0.042 14.0 0.0 0.17 12.0 0.0 2.0 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDN08819.1 - 0.082 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF1295 PF06966.12 EDN08820.1 - 0.1 12.1 2.9 3.5 7.1 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1295) Topoisom_bac PF01131.20 EDN08821.1 - 7.1e-98 328.3 0.0 8.9e-98 328.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EDN08821.1 - 9.6e-18 64.3 0.0 3.6e-17 62.5 0.0 2.0 1 1 0 1 1 1 1 Toprim domain MscS_porin PF12795.7 EDN08822.1 - 4.4e-07 29.7 50.2 9.4e-06 25.3 2.9 5.5 4 1 1 5 5 5 4 Mechanosensitive ion channel porin domain Fez1 PF06818.15 EDN08822.1 - 0.0055 17.2 51.3 0.05 14.0 8.7 4.6 2 2 1 4 4 4 3 Fez1 Spc7 PF08317.11 EDN08822.1 - 0.0056 15.6 52.6 0.024 13.6 2.5 4.4 2 1 2 4 4 4 3 Spc7 kinetochore protein TRPM_tetra PF16519.5 EDN08822.1 - 0.17 12.0 0.2 0.17 12.0 0.2 4.2 4 0 0 4 4 4 0 Tetramerisation domain of TRPM GAS PF13851.6 EDN08822.1 - 0.25 10.7 50.0 0.023 14.1 13.5 4.7 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Bacillus_HBL PF05791.11 EDN08822.1 - 1.6 8.5 41.1 0.034 14.0 4.8 5.9 3 2 4 7 7 7 0 Bacillus haemolytic enterotoxin (HBL) DUF1515 PF07439.11 EDN08822.1 - 2.4 8.2 18.7 2.8 8.0 0.2 5.1 2 1 1 4 4 4 0 Protein of unknown function (DUF1515) Golgin_A5 PF09787.9 EDN08823.1 - 0.022 14.2 4.9 0.11 11.9 2.5 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 EzrA PF06160.12 EDN08823.1 - 0.033 12.4 2.3 0.051 11.7 1.1 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA DUF5082 PF16888.5 EDN08823.1 - 0.042 14.1 0.8 0.84 9.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF4559 PF15112.6 EDN08823.1 - 0.065 12.9 1.0 0.11 12.2 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF4618 PF15397.6 EDN08823.1 - 0.074 12.5 2.8 3.7 6.9 2.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Baculo_PEP_C PF04513.12 EDN08823.1 - 0.15 12.1 3.1 18 5.3 2.5 3.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TelA PF05816.11 EDN08823.1 - 0.16 11.0 3.6 2.1 7.3 1.3 2.1 1 1 0 2 2 2 0 Toxic anion resistance protein (TelA) ApoLp-III PF07464.11 EDN08823.1 - 0.27 11.3 1.7 34 4.5 0.0 2.9 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF1664 PF07889.12 EDN08823.1 - 0.32 11.0 3.1 16 5.6 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF1640 PF07798.11 EDN08823.1 - 0.52 10.3 4.8 1 9.4 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) DUF4149 PF13664.6 EDN08824.1 - 2.1e-26 92.2 1.6 4.6e-26 91.1 0.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Ku_PK_bind PF08785.11 EDN08825.1 - 8.1e-35 119.6 0.0 2.1e-34 118.2 0.0 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EDN08825.1 - 7.6e-32 110.7 0.0 1.3e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EDN08825.1 - 6.1e-05 22.9 0.0 0.00016 21.5 0.0 1.7 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain PX PF00787.24 EDN08826.1 - 4.8e-15 55.5 0.0 2.3e-14 53.3 0.0 1.9 2 0 0 2 2 2 1 PX domain DUF676 PF05057.14 EDN08827.1 - 4.9e-05 22.9 0.0 8.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) UPF0227 PF05728.12 EDN08827.1 - 0.00016 21.7 0.0 0.00038 20.4 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Lipase_3 PF01764.25 EDN08827.1 - 0.00033 20.5 0.1 0.00086 19.2 0.0 1.6 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EDN08827.1 - 0.0015 19.1 0.0 0.0029 18.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EDN08827.1 - 0.0031 17.3 0.0 0.0072 16.1 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein LIDHydrolase PF10230.9 EDN08827.1 - 0.021 14.4 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EDN08827.1 - 0.03 13.6 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDN08827.1 - 0.045 13.9 0.4 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_1 PF00561.20 EDN08827.1 - 0.065 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EDN08827.1 - 0.096 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Striatin PF08232.12 EDN08827.1 - 1.8 9.2 7.6 4.3 7.9 7.6 1.6 1 0 0 1 1 1 0 Striatin family SIP1 PF04938.12 EDN08828.1 - 5.3e-07 29.6 0.0 7.6e-05 22.5 0.0 2.4 2 1 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) Phage_TAC_11 PF11836.8 EDN08828.1 - 0.075 13.2 0.5 0.15 12.2 0.5 1.5 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 tRNA-synt_2 PF00152.20 EDN08829.1 - 3.5e-70 236.6 0.0 4.8e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Hydrolase_like PF13242.6 EDN08829.1 - 3.5e-09 36.6 0.0 8.2e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like DUF4129 PF13559.6 EDN08829.1 - 0.044 14.0 0.1 0.13 12.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) F-box-like PF12937.7 EDN08830.1 - 1.3e-10 41.0 2.3 3.7e-10 39.5 2.3 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EDN08830.1 - 0.044 14.2 6.3 16 6.1 0.2 4.7 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) F-box PF00646.33 EDN08830.1 - 0.07 13.0 1.1 0.22 11.4 0.2 2.4 2 0 0 2 2 2 0 F-box domain Adaptin_N PF01602.20 EDN08831.1 - 8.4e-94 315.0 0.0 2.2e-53 181.6 0.4 2.1 1 1 1 2 2 2 2 Adaptin N terminal region COP-gamma_platf PF08752.10 EDN08831.1 - 1.6e-59 200.4 1.6 3.6e-59 199.2 1.6 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EDN08831.1 - 1.1e-27 96.5 4.5 2.9e-26 91.9 2.4 3.2 2 1 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EDN08831.1 - 2.7e-18 66.1 3.8 8.1e-13 48.6 0.1 4.9 5 1 1 6 6 6 2 HEAT repeats Cnd1 PF12717.7 EDN08831.1 - 2e-06 27.9 8.0 0.022 14.8 0.1 4.4 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EDN08831.1 - 0.0013 19.3 3.8 8.3 7.4 0.1 4.5 4 0 0 4 4 4 2 PBS lyase HEAT-like repeat HEAT PF02985.22 EDN08831.1 - 0.0018 18.3 6.8 0.3 11.5 0.3 5.8 6 0 0 6 6 6 1 HEAT repeat Phosducin PF02114.16 EDN08832.1 - 0.0018 17.3 0.0 0.0018 17.3 0.0 1.0 1 0 0 1 1 1 1 Phosducin bZIP_1 PF00170.21 EDN08833.1 - 2.7e-06 27.4 13.9 5e-06 26.5 13.5 1.6 1 1 1 2 2 2 1 bZIP transcription factor SHE3 PF17078.5 EDN08833.1 - 4.7e-06 26.5 6.7 7e-06 25.9 6.7 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 FlaC_arch PF05377.11 EDN08833.1 - 0.024 15.0 1.2 0.048 14.1 1.2 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Scaffolding_pro PF11418.8 EDN08833.1 - 0.029 14.9 0.2 0.061 13.9 0.2 1.5 1 0 0 1 1 1 0 Phi29 scaffolding protein bZIP_Maf PF03131.17 EDN08833.1 - 0.077 13.5 12.2 0.12 12.9 12.2 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor GAS PF13851.6 EDN08833.1 - 0.086 12.2 8.2 0.13 11.6 8.2 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding GldM_N PF12081.8 EDN08833.1 - 0.097 12.8 1.2 0.14 12.2 1.2 1.2 1 0 0 1 1 1 0 GldM N-terminal domain Pox_A_type_inc PF04508.12 EDN08833.1 - 0.12 12.3 2.4 0.51 10.3 2.4 2.1 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Macoilin PF09726.9 EDN08833.1 - 0.2 10.2 4.3 0.27 9.7 4.3 1.1 1 0 0 1 1 1 0 Macoilin family Glutaredoxin2_C PF04399.13 EDN08833.1 - 0.22 11.4 0.9 0.42 10.4 0.9 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain TMF_TATA_bd PF12325.8 EDN08833.1 - 0.28 11.4 7.0 0.49 10.6 7.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CCDC106 PF15794.5 EDN08833.1 - 0.48 10.1 10.0 1.3 8.7 8.7 1.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 V_ATPase_I PF01496.19 EDN08833.1 - 0.92 7.3 4.2 1.2 6.9 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_2 PF07716.15 EDN08833.1 - 1.1 9.4 17.7 0.9 9.7 15.2 1.9 1 1 1 2 2 2 0 Basic region leucine zipper UPF0242 PF06785.11 EDN08833.1 - 3.7 7.6 7.8 5.9 6.9 7.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MPS2 PF17060.5 EDN08833.1 - 4.2 6.5 8.2 30 3.7 8.0 1.9 1 1 0 1 1 1 0 Monopolar spindle protein 2 DivIC PF04977.15 EDN08833.1 - 7.8 6.4 9.1 3.4 7.5 0.5 2.2 1 1 1 2 2 2 0 Septum formation initiator MFS_1 PF07690.16 EDN08834.1 - 0.0018 17.2 5.2 0.0022 17.0 5.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1304 PF06993.12 EDN08834.1 - 0.095 12.7 4.1 0.4 10.7 4.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1304) YesK PF14150.6 EDN08834.1 - 0.19 11.9 5.8 0.26 11.5 5.8 1.2 1 0 0 1 1 1 0 YesK-like protein MFS_1 PF07690.16 EDN08835.1 - 6.7e-14 51.6 6.4 7.8e-14 51.4 6.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MASE2 PF05230.11 EDN08835.1 - 0.003 17.6 0.1 0.02 14.9 0.0 2.2 2 0 0 2 2 2 1 MASE2 domain Glyco_hydro_47 PF01532.20 EDN08836.1 - 1.1e-171 571.8 0.0 1.3e-171 571.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 EDN08836.1 - 0.018 13.6 0.0 1 7.8 0.0 2.2 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 DUF3716 PF12511.8 EDN08837.1 - 1.2e-14 54.0 2.0 1.8e-14 53.5 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) NDC10_II PF16787.5 EDN08838.1 - 1.1e-37 129.8 6.0 3.9e-23 82.0 0.0 2.5 2 1 1 3 3 3 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN08838.1 - 2.7e-12 46.8 0.2 1.9e-11 44.1 0.0 2.4 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes PSII_Pbs27 PF13326.6 EDN08838.1 - 0.072 13.4 0.5 0.13 12.6 0.5 1.4 1 0 0 1 1 1 0 Photosystem II Pbs27 DUF3435 PF11917.8 EDN08839.1 - 3e-139 464.6 3.2 2.4e-77 260.6 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) Sec23_helical PF04815.15 EDN08840.1 - 0.02 14.7 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Dynamin_M PF01031.20 EDN08842.1 - 1.5e-20 73.6 0.0 2.6e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EDN08842.1 - 1.1e-13 51.6 0.1 5.8e-08 33.0 0.0 2.8 1 1 1 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 EDN08842.1 - 0.00085 19.4 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EDN08842.1 - 0.0048 16.6 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EDN08842.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3723 PF12520.8 EDN08843.1 - 2.6e-162 541.1 0.0 2.6e-162 541.1 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF3723) Pkinase PF00069.25 EDN08844.1 - 1.1e-07 31.5 0.0 1.7e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08844.1 - 9.2e-07 28.4 0.0 1.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FAD_binding_8 PF08022.12 EDN08845.1 - 4.9e-10 39.5 0.0 8.8e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDN08845.1 - 1.8e-08 34.6 0.0 2.4e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF3435 PF11917.8 EDN08847.1 - 7.9e-155 515.9 0.3 1e-154 515.5 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Pkinase PF00069.25 EDN08848.1 - 2.2e-24 86.3 0.0 3e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08848.1 - 5.1e-07 29.2 0.0 2.7e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EDN08848.1 - 0.004 16.5 0.0 0.0062 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN08848.1 - 0.013 15.5 0.0 0.11 12.4 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family S-l_SbsC_C PF18316.1 EDN08849.1 - 0.0035 17.8 1.3 0.43 11.1 0.3 2.5 1 1 1 2 2 2 2 S-layer protein SbsC C-terminal domain Fe_dep_repr_C PF02742.15 EDN08849.1 - 0.057 13.5 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain Exo_endo_phos_2 PF14529.6 EDN08850.1 - 3.5e-28 97.8 0.2 9e-28 96.5 0.2 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN08850.1 - 0.00041 19.9 0.4 0.00079 19.0 0.4 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 EDN08851.1 - 4.6e-27 95.0 0.0 9.2e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN08851.1 - 7.2e-13 48.9 0.1 1.6e-12 47.8 0.1 1.6 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN08851.1 - 0.013 15.3 0.1 0.062 13.1 0.1 2.1 1 1 0 1 1 1 0 Reverse transcriptase-like zf-RVT PF13966.6 EDN08851.1 - 0.065 14.0 0.1 0.19 12.4 0.1 1.8 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase Bunya_NS-S PF01104.17 EDN08852.1 - 0.23 11.3 0.0 0.28 11.0 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-s APH PF01636.23 EDN08854.1 - 3e-15 56.8 0.0 7.1e-15 55.6 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EDN08854.1 - 0.033 13.1 0.0 0.8 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) DNA_pol_A_exo1 PF01612.20 EDN08855.1 - 4.9e-05 23.1 0.0 0.00012 21.9 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease NAD1 PF18778.1 EDN08855.1 - 0.051 13.7 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Myb_DNA-binding PF00249.31 EDN08856.1 - 2.3e-13 50.1 0.1 2.3e-13 50.1 0.1 2.3 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08856.1 - 6.6e-08 32.7 6.4 6e-07 29.6 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF3461 PF11944.8 EDN08857.1 - 0.01 16.0 1.7 0.019 15.1 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) Pkinase PF00069.25 EDN08862.1 - 6.1e-26 91.4 0.0 7.7e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08862.1 - 3.8e-14 52.6 0.0 5e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN08862.1 - 4.4e-09 35.6 0.4 6.3e-09 35.1 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EDN08862.1 - 0.00011 22.2 0.0 0.0015 18.5 0.0 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family Hydantoinase_B PF02538.14 EDN08864.1 - 7e-218 724.2 0.2 8.9e-218 723.9 0.2 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EDN08864.1 - 4.9e-104 347.7 0.0 1.3e-103 346.3 0.0 1.7 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDN08864.1 - 1.1e-57 194.6 0.2 4.8e-56 189.3 0.0 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region DUF1977 PF09320.11 EDN08865.1 - 0.017 15.4 0.4 0.021 15.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1977) Kelch_6 PF13964.6 EDN08866.1 - 9.8e-28 95.5 0.5 1.8e-10 40.7 0.3 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EDN08866.1 - 3e-27 94.4 6.7 5.6e-09 35.9 0.7 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EDN08866.1 - 6.8e-26 89.8 1.8 8.9e-07 28.8 0.1 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 EDN08866.1 - 2.3e-24 84.7 0.0 2.5e-12 46.2 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EDN08866.1 - 3.6e-23 81.3 5.9 8.6e-06 25.9 0.1 4.9 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EDN08866.1 - 2e-20 71.9 1.3 1.6e-08 34.2 0.1 5.6 5 0 0 5 5 5 4 Kelch motif TRAF_BIRC3_bd PF16673.5 EDN08866.1 - 2.1 8.2 12.6 0.024 14.4 1.0 3.7 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Raptor_N PF14538.6 EDN08867.1 - 1.1e-64 216.8 0.0 1.8e-64 216.1 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 EDN08867.1 - 0.012 15.8 3.1 3.9 8.0 0.0 4.3 5 0 0 5 5 5 0 HEAT repeat WD40 PF00400.32 EDN08867.1 - 0.047 14.6 10.3 0.67 10.9 0.0 4.6 4 1 0 4 4 4 0 WD domain, G-beta repeat zf-RING_2 PF13639.6 EDN08869.1 - 7.7e-13 48.6 5.6 1.2e-12 47.9 5.6 1.3 1 0 0 1 1 1 1 Ring finger domain PA PF02225.22 EDN08869.1 - 7.3e-09 35.5 0.0 1.9e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.6 EDN08869.1 - 7.3e-09 35.3 4.4 1.2e-08 34.7 4.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDN08869.1 - 7.9e-09 35.1 2.7 7.9e-09 35.1 2.7 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EDN08869.1 - 1.5e-08 34.8 2.9 3e-08 33.8 2.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDN08869.1 - 2.1e-08 33.9 3.9 3.3e-08 33.3 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDN08869.1 - 2e-07 30.8 3.0 3.2e-07 30.2 3.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDN08869.1 - 5.1e-06 26.2 3.1 7.7e-06 25.7 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN08869.1 - 9.1e-06 25.6 2.1 7.7e-05 22.6 2.8 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDN08869.1 - 0.00074 19.5 0.5 0.0014 18.7 0.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDN08869.1 - 0.0027 17.5 3.0 0.0046 16.8 3.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDN08869.1 - 0.038 14.1 2.6 0.087 13.0 2.6 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 EDN08869.1 - 0.05 13.8 2.3 0.12 12.5 2.3 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EDN08869.1 - 0.054 13.1 2.7 0.1 12.2 2.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EDN08869.1 - 0.47 10.6 4.2 0.91 9.7 4.2 1.5 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.29 EDN08869.1 - 0.65 9.9 2.7 1.2 9.1 2.7 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 EDN08869.1 - 0.89 9.4 3.2 1.5 8.6 3.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EDN08869.1 - 1.3 9.4 3.5 2.4 8.5 3.5 1.4 1 0 0 1 1 1 0 RING-like domain Chitin_bind_1 PF00187.19 EDN08871.1 - 4.4e-05 23.9 44.5 0.0015 18.9 12.4 3.5 3 0 0 3 3 3 2 Chitin recognition protein LysM PF01476.20 EDN08871.1 - 0.035 14.2 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 LysM domain Y_phosphatase3 PF13350.6 EDN08872.1 - 5.9e-54 183.5 0.0 7.2e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EDN08872.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDN08872.1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FHA PF00498.26 EDN08873.1 - 3.6e-16 59.3 0.0 1.1e-15 57.7 0.0 2.0 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EDN08873.1 - 0.00028 21.1 0.0 0.00079 19.7 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF2203 PF09969.9 EDN08873.1 - 0.18 12.5 11.0 0.3 11.8 1.2 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) KIP1 PF07765.12 EDN08873.1 - 0.64 10.2 6.1 0.57 10.3 2.9 2.4 2 0 0 2 2 2 0 KIP1-like protein DMSP_lyase PF16867.5 EDN08873.1 - 1.3 8.7 6.1 0.21 11.2 0.3 2.2 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase MRPL52 PF18699.1 EDN08873.1 - 1.3 9.3 9.9 8.3 6.7 3.3 2.8 2 0 0 2 2 2 0 Mitoribosomal protein mL52 DUF1515 PF07439.11 EDN08873.1 - 2.7 8.0 11.7 0.53 10.3 2.8 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) Romo1 PF10247.9 EDN08874.1 - 4.3e-25 87.9 18.8 6.5e-25 87.3 18.8 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 EDN08874.1 - 0.052 13.9 7.3 0.081 13.3 7.3 1.3 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Papilin_u7 PF16626.5 EDN08876.1 - 0.055 14.0 0.2 0.58 10.8 0.1 1.9 2 0 0 2 2 2 0 Linking region between Kunitz_BPTI and I-set on papilin DUF3493 PF11998.8 EDN08877.1 - 1.1 9.5 3.8 1.3 9.3 1.0 2.0 1 1 1 2 2 2 0 Low psii accumulation1 / Rep27 LRR_8 PF13855.6 EDN08879.1 - 1.7e-10 40.5 2.9 2e-10 40.3 1.1 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EDN08879.1 - 3e-08 33.8 2.4 2.6e-05 24.5 0.2 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) Rad50_zn_hook PF04423.14 EDN08879.1 - 0.00066 19.5 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Rad50 zinc hook motif LRR_1 PF00560.33 EDN08879.1 - 0.01 16.2 3.4 6.5 7.7 0.0 3.7 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 EDN08879.1 - 0.22 11.7 4.7 2.4 8.4 0.1 3.1 3 0 0 3 3 3 0 Leucine Rich repeat DUF2256 PF10013.9 EDN08879.1 - 1.7 8.8 6.5 0.35 11.0 2.6 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Ribosomal_S14 PF00253.21 EDN08880.1 - 4.8e-21 74.3 3.9 2e-20 72.3 0.8 2.2 2 0 0 2 2 2 2 Ribosomal protein S14p/S29e PAG PF15347.6 EDN08881.1 - 0.027 13.5 3.5 0.04 12.9 3.5 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched FAM176 PF14851.6 EDN08881.1 - 0.11 12.1 1.6 0.11 12.1 1.6 1.2 1 0 0 1 1 1 0 FAM176 family PBP1_TM PF14812.6 EDN08881.1 - 0.43 11.0 6.0 0.67 10.4 6.0 1.4 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EDN08881.1 - 0.44 9.8 4.7 0.49 9.7 4.7 1.1 1 0 0 1 1 1 0 NOA36 protein NESP55 PF06390.12 EDN08881.1 - 1 8.9 15.0 0.4 10.2 1.5 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) DNA_pol_phi PF04931.13 EDN08881.1 - 1.5 6.8 6.5 1.5 6.8 6.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi ATP-synt_J PF04911.12 EDN08882.1 - 1.1e-25 89.0 1.6 1.2e-25 88.8 1.6 1.0 1 0 0 1 1 1 1 ATP synthase j chain DASH_Spc19 PF08287.11 EDN08883.1 - 2.7e-54 183.3 7.8 3.7e-54 182.9 7.8 1.2 1 0 0 1 1 1 1 Spc19 Mur_ligase_M PF08245.12 EDN08883.1 - 0.019 14.9 0.2 0.029 14.3 0.2 1.5 1 1 0 1 1 1 0 Mur ligase middle domain LPD30 PF18850.1 EDN08883.1 - 0.036 13.8 0.2 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Large polyvalent protein associated domain 30 Rogdi_lz PF10259.9 EDN08884.1 - 1.4e-80 270.6 0.0 2.4e-80 269.9 0.0 1.4 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Rsm22 PF09243.10 EDN08884.1 - 1.8e-28 99.6 0.0 2.1e-27 96.1 0.0 2.4 2 1 0 2 2 2 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 EDN08884.1 - 0.003 17.4 0.0 0.009 15.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain SUR7 PF06687.12 EDN08885.1 - 4.7e-41 140.8 6.4 5.4e-41 140.5 6.4 1.0 1 0 0 1 1 1 1 SUR7/PalI family CrgA PF06781.12 EDN08885.1 - 0.2 11.7 4.2 0.26 11.4 2.5 2.1 2 0 0 2 2 2 0 Cell division protein CrgA Clc-like PF07062.12 EDN08885.1 - 0.42 10.1 5.3 0.055 12.9 1.1 1.6 2 0 0 2 2 2 0 Clc-like Amastin PF07344.11 EDN08885.1 - 2.2 8.1 15.8 0.065 13.1 8.1 2.2 3 1 0 3 3 3 0 Amastin surface glycoprotein DUF2070 PF09843.9 EDN08885.1 - 3.7 5.7 4.6 5.2 5.2 4.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HSP70 PF00012.20 EDN08886.1 - 1e-43 149.5 0.4 2e-40 138.6 0.1 2.4 1 1 0 2 2 2 2 Hsp70 protein PilM_2 PF11104.8 EDN08886.1 - 0.0069 15.5 0.0 2.5 7.0 0.0 2.2 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; DUF4611 PF15387.6 EDN08886.1 - 0.017 15.3 1.3 0.036 14.3 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) GCIP PF13324.6 EDN08886.1 - 0.05 13.2 1.1 0.086 12.4 1.1 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Cwf_Cwc_15 PF04889.12 EDN08886.1 - 0.13 12.0 5.0 0.23 11.2 5.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 EDN08886.1 - 0.41 11.1 5.6 0.77 10.2 5.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3073 PF11273.8 EDN08886.1 - 0.43 11.3 3.3 1.2 10.0 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) DNA_pol_phi PF04931.13 EDN08886.1 - 6.2 4.8 7.6 8.9 4.3 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Rpp20 PF12328.8 EDN08887.1 - 2.1e-50 170.2 14.8 4.4e-50 169.2 14.8 1.5 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EDN08887.1 - 1.6e-18 66.3 0.8 3e-18 65.4 0.8 1.5 1 0 0 1 1 1 1 Alba KH_6 PF15985.5 EDN08888.1 - 4.4e-17 62.2 0.5 8.3e-17 61.3 0.5 1.5 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EDN08888.1 - 0.00016 21.6 2.0 0.00033 20.5 2.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain PhzC-PhzF PF02567.16 EDN08890.1 - 5.9e-10 39.1 0.0 0.00016 21.3 0.0 2.2 2 1 0 2 2 2 2 Phenazine biosynthesis-like protein Glyco_transf_24 PF18404.1 EDN08893.1 - 1.5e-148 493.4 1.5 2.5e-148 492.7 1.5 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EDN08893.1 - 1.2e-62 212.2 0.0 4.6e-62 210.3 0.0 2.1 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EDN08893.1 - 2.8e-42 143.8 0.1 8.1e-42 142.4 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EDN08893.1 - 1.4e-40 137.8 0.0 3.5e-40 136.5 0.0 1.8 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_15 PF18403.1 EDN08893.1 - 6.6e-39 134.0 1.0 3.3e-38 131.7 0.2 2.4 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EDN08893.1 - 4.5e-35 121.2 0.7 3.1e-29 102.2 0.1 2.8 1 1 1 2 2 2 2 Thioredoxin-like domain Acyl-CoA_dh_1 PF00441.24 EDN08893.1 - 2.1e-32 112.4 0.4 4.3e-32 111.4 0.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 EDN08893.1 - 4.2e-06 27.1 0.0 9.9e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_transf_8 PF01501.20 EDN08893.1 - 0.00056 19.6 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Myb_DNA-binding PF00249.31 EDN08894.1 - 6.7e-17 61.4 1.6 3.1e-07 30.5 0.0 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN08894.1 - 3.7e-14 52.7 0.6 3.8e-09 36.7 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Med3 PF11593.8 EDN08894.1 - 0.0024 17.2 0.8 0.0041 16.4 0.8 1.3 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Myb_DNA-bind_4 PF13837.6 EDN08894.1 - 0.016 15.6 3.6 0.066 13.6 3.6 2.0 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EDN08894.1 - 0.16 12.3 1.6 0.29 11.5 0.2 2.1 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_7 PF15963.5 EDN08894.1 - 0.16 11.8 1.9 0.25 11.3 0.0 2.1 2 1 1 3 3 3 0 Myb DNA-binding like DUF3717 PF12512.8 EDN08894.1 - 0.17 11.8 0.4 3.2 7.7 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3717) SANT_DAMP1_like PF16282.5 EDN08894.1 - 0.18 12.0 0.3 0.86 9.8 0.1 2.1 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 Amidohydro_1 PF01979.20 EDN08895.1 - 9.5e-28 97.5 0.0 6.5e-19 68.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 EDN08895.1 - 3.9e-11 43.1 0.1 1.1e-06 28.4 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family BSP_II PF05432.11 EDN08895.1 - 0.0016 18.2 9.5 0.0023 17.7 9.5 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) PTPRCAP PF15713.5 EDN08895.1 - 0.0022 18.3 1.4 0.0041 17.4 1.4 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated SDA1 PF05285.12 EDN08895.1 - 0.031 13.7 4.7 0.043 13.3 4.7 1.1 1 0 0 1 1 1 0 SDA1 AAR2 PF05282.11 EDN08895.1 - 0.043 13.2 1.9 0.064 12.7 1.9 1.2 1 0 0 1 1 1 0 AAR2 protein Amidohydro_2 PF04909.14 EDN08895.1 - 0.073 12.8 0.1 0.2 11.4 0.1 1.7 1 1 0 1 1 1 0 Amidohydrolase Nop14 PF04147.12 EDN08895.1 - 0.1 10.8 3.0 0.13 10.5 3.0 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 EDN08895.1 - 0.61 8.8 2.4 0.88 8.3 2.4 1.2 1 0 0 1 1 1 0 Presenilin DUF2457 PF10446.9 EDN08895.1 - 0.7 9.0 12.5 1 8.5 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 EDN08895.1 - 1.2 7.4 6.6 1.6 6.9 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 EDN08895.1 - 5.4 5.3 7.2 7.5 4.8 7.2 1.1 1 0 0 1 1 1 0 Menin NPR3 PF03666.13 EDN08895.1 - 6.5 5.4 7.1 9.9 4.8 7.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2076 PF09849.9 EDN08895.1 - 8.8 6.3 11.8 15 5.5 11.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Vma12 PF11712.8 EDN08896.1 - 1.3e-38 132.2 0.0 1.8e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Prefoldin PF02996.17 EDN08897.1 - 7.8e-29 100.0 0.1 1.1e-28 99.6 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit End3 PF12761.7 EDN08897.1 - 0.026 14.7 0.3 0.12 12.5 0.0 1.9 1 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 GRAM PF02893.20 EDN08898.1 - 6e-14 51.9 0.9 0.00031 20.6 0.0 3.5 3 0 0 3 3 3 3 GRAM domain PH PF00169.29 EDN08898.1 - 4.4e-13 49.6 0.4 8.4e-12 45.5 0.1 2.5 2 0 0 2 2 2 1 PH domain Glyco_transf_28 PF03033.20 EDN08898.1 - 2.1e-08 34.3 0.0 5.4e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH_11 PF15413.6 EDN08898.1 - 1.2e-06 28.9 0.4 2.9e-06 27.6 0.4 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EDN08898.1 - 0.00011 22.3 0.1 0.0004 20.5 0.1 1.9 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 EDN08898.1 - 0.0035 17.6 0.5 0.01 16.1 0.5 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 EDN08898.1 - 0.0065 16.8 0.1 0.016 15.6 0.1 1.6 1 0 0 1 1 1 1 Plant pleckstrin homology-like region UDPGT PF00201.18 EDN08898.1 - 0.014 14.2 0.0 0.032 13.0 0.0 1.5 1 1 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase PH_13 PF16652.5 EDN08898.1 - 0.076 12.8 0.2 0.16 11.8 0.2 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Prenylcys_lyase PF07156.14 EDN08899.1 - 7.5e-87 291.8 0.3 1e-86 291.3 0.3 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 EDN08899.1 - 6.3e-12 45.6 0.1 5.1e-11 42.6 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EDN08899.1 - 7.8e-09 35.3 0.0 1.6e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EDN08899.1 - 7.5e-06 25.8 0.1 1.3e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN08899.1 - 0.0018 17.6 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN08899.1 - 0.08 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EDN08899.1 - 0.098 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF3376 PF11856.8 EDN08901.1 - 0.0042 16.1 0.6 0.0045 16.0 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3376) TarH PF02203.15 EDN08901.1 - 0.027 14.4 1.2 0.039 13.9 1.2 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue CSN8_PSD8_EIF3K PF10075.9 EDN08903.1 - 1.9e-49 167.4 0.0 2.6e-49 166.9 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PDCD2_C PF04194.13 EDN08904.1 - 2.2e-36 125.5 0.0 8.9e-35 120.3 0.0 2.5 2 1 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain A2L_zn_ribbon PF08792.10 EDN08904.1 - 0.053 13.3 3.4 0.56 10.0 0.1 2.6 3 0 0 3 3 3 0 A2L zinc ribbon domain Folliculin PF11704.8 EDN08905.1 - 2.9e-49 167.5 0.0 4e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport RNA_polI_A34 PF08208.11 EDN08908.1 - 1.1e-12 48.5 17.7 1.1e-12 48.5 17.7 2.0 1 1 1 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 SHMT PF00464.19 EDN08909.1 - 2.7e-138 460.9 0.1 3.4e-137 457.3 0.1 1.9 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EDN08909.1 - 0.011 14.9 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDN08909.1 - 0.025 13.9 0.0 0.052 12.8 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase DUF3040 PF11239.8 EDN08909.1 - 0.073 13.3 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) MEDS PF14417.6 EDN08909.1 - 0.077 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Cys_Met_Meta_PP PF01053.20 EDN08909.1 - 0.14 10.6 0.0 0.2 10.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme iPGM_N PF06415.13 EDN08910.1 - 4.3e-73 245.3 0.2 9.4e-72 241.0 0.2 2.1 1 1 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EDN08910.1 - 3.2e-71 239.6 0.0 3.7e-71 239.4 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EDN08910.1 - 3.9e-06 26.5 0.0 2.6e-05 23.8 0.0 2.2 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EDN08910.1 - 1.6e-05 24.7 0.0 2.6e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.20 EDN08910.1 - 0.0037 16.3 0.2 0.022 13.7 0.1 2.0 2 0 0 2 2 2 1 Alkaline phosphatase PglZ PF08665.12 EDN08910.1 - 0.083 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 PglZ domain AAA PF00004.29 EDN08912.1 - 6.3e-41 139.9 0.0 1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDN08912.1 - 4.1e-15 55.5 0.0 1.6e-14 53.6 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EDN08912.1 - 4.7e-07 29.5 0.0 1.4e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDN08912.1 - 6.3e-06 26.7 0.0 0.00068 20.1 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EDN08912.1 - 1.4e-05 24.4 0.0 0.00044 19.5 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EDN08912.1 - 1.6e-05 24.7 0.0 2.6e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDN08912.1 - 2.2e-05 24.7 0.1 0.007 16.6 0.0 2.5 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDN08912.1 - 3.2e-05 24.3 0.0 0.0091 16.4 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 EDN08912.1 - 4.4e-05 23.5 0.0 0.00015 21.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDN08912.1 - 4.6e-05 23.2 0.0 0.00011 22.0 0.0 1.6 1 1 0 1 1 1 1 IstB-like ATP binding protein MIT PF04212.18 EDN08912.1 - 8.1e-05 22.6 2.0 0.00012 22.1 0.1 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TIP49 PF06068.13 EDN08912.1 - 9.2e-05 21.8 0.0 0.00015 21.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 EDN08912.1 - 0.00016 21.3 0.1 0.059 12.9 0.0 3.4 2 2 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EDN08912.1 - 0.00016 21.7 0.0 0.00037 20.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDN08912.1 - 0.00036 21.1 0.2 0.002 18.7 0.0 2.4 3 1 0 3 3 1 1 AAA domain AAA_33 PF13671.6 EDN08912.1 - 0.00047 20.3 0.0 0.0023 18.1 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_17 PF13207.6 EDN08912.1 - 0.0024 18.3 0.0 0.032 14.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDN08912.1 - 0.0032 17.2 0.1 0.0095 15.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EDN08912.1 - 0.0043 17.2 0.0 0.0099 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EDN08912.1 - 0.0084 15.6 0.0 0.043 13.3 0.0 2.2 2 1 0 2 2 2 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EDN08912.1 - 0.011 15.1 0.2 0.04 13.3 0.1 2.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 EDN08912.1 - 0.014 15.5 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Torsin Parvo_NS1 PF01057.17 EDN08912.1 - 0.02 14.0 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EDN08912.1 - 0.029 14.3 0.4 0.37 10.7 0.0 2.4 2 1 1 3 3 2 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EDN08912.1 - 0.038 13.3 0.0 2.5 7.4 0.0 2.7 2 1 1 3 3 3 0 KaiC PhoH PF02562.16 EDN08912.1 - 0.04 13.4 0.0 0.089 12.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 EDN08912.1 - 0.053 12.8 0.2 0.22 10.8 0.0 2.1 2 1 1 3 3 3 0 Zeta toxin NACHT PF05729.12 EDN08912.1 - 0.056 13.4 0.0 0.29 11.0 0.0 2.1 1 1 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 EDN08912.1 - 0.082 12.6 0.0 0.24 11.1 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain CPT PF07931.12 EDN08912.1 - 0.082 12.7 0.1 0.25 11.2 0.0 1.8 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 EDN08912.1 - 0.1 12.3 2.7 0.4 10.4 0.1 2.9 4 0 0 4 4 4 0 Cytidylate kinase ABC_tran PF00005.27 EDN08912.1 - 0.18 12.3 0.0 0.63 10.6 0.0 2.2 1 1 0 1 1 1 0 ABC transporter PACT_coil_coil PF10495.9 EDN08913.1 - 1e-19 70.9 0.8 1e-19 70.9 0.8 3.0 2 1 0 2 2 2 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein TSC22 PF01166.18 EDN08913.1 - 0.0078 16.5 0.3 0.0078 16.5 0.3 4.3 4 1 0 4 4 4 2 TSC-22/dip/bun family DUF4407 PF14362.6 EDN08913.1 - 0.43 9.9 31.7 0.096 12.0 11.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Shugoshin_N PF07558.11 EDN08913.1 - 2.1 8.3 11.0 0.11 12.3 0.7 4.1 4 1 1 5 5 5 0 Shugoshin N-terminal coiled-coil region Spc110_C PF18520.1 EDN08913.1 - 2.6 7.7 7.8 0.51 10.0 1.3 2.6 2 0 0 2 2 2 0 Spindle pole body component 110 C-terminal domain Cnn_1N PF07989.11 EDN08914.1 - 9.1e-25 86.6 8.2 9.1e-25 86.6 8.2 6.9 1 1 3 4 4 3 1 Centrosomin N-terminal motif 1 Cep57_CLD_2 PF14197.6 EDN08914.1 - 0.00015 21.8 11.5 0.00015 21.8 11.5 6.5 2 2 3 5 5 2 1 Centrosome localisation domain of PPC89 Spc7 PF08317.11 EDN08914.1 - 0.0032 16.4 24.3 0.0032 16.4 24.3 3.8 1 1 1 3 3 3 1 Spc7 kinetochore protein Fez1 PF06818.15 EDN08914.1 - 0.0039 17.7 65.5 0.016 15.7 29.5 3.1 1 1 1 2 2 2 1 Fez1 Atg14 PF10186.9 EDN08914.1 - 0.0062 15.7 61.5 0.0087 15.2 23.2 3.2 1 1 2 3 3 3 2 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 EDN08914.1 - 0.0065 16.8 71.2 0.014 15.7 13.6 4.2 1 1 3 4 4 4 2 Outer membrane protein (OmpH-like) ZapB PF06005.12 EDN08914.1 - 0.007 16.8 14.4 0.007 16.8 14.4 6.1 2 2 3 5 5 4 1 Cell division protein ZapB Alanine_zipper PF11839.8 EDN08914.1 - 0.014 15.7 9.3 0.014 15.7 9.3 3.9 4 1 1 5 5 3 0 Alanine-zipper, major outer membrane lipoprotein Lebercilin PF15619.6 EDN08914.1 - 0.015 14.9 79.3 0.035 13.8 27.7 3.5 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Golgin_A5 PF09787.9 EDN08914.1 - 0.016 14.7 74.2 0.19 11.2 27.0 3.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 BST2 PF16716.5 EDN08914.1 - 0.018 15.6 12.7 0.018 15.6 12.7 5.6 2 1 2 5 5 3 0 Bone marrow stromal antigen 2 CENP-F_leu_zip PF10473.9 EDN08914.1 - 0.02 14.9 81.1 0.25 11.4 18.1 4.2 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2681 PF10883.8 EDN08914.1 - 0.03 14.7 3.1 0.03 14.7 3.1 6.1 1 1 3 6 6 6 0 Protein of unknown function (DUF2681) PspA_IM30 PF04012.12 EDN08914.1 - 0.038 13.6 56.7 1.1 8.8 19.7 3.3 1 1 2 3 3 3 0 PspA/IM30 family SesA PF17107.5 EDN08914.1 - 0.052 13.7 30.5 0.32 11.2 6.3 3.4 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_MLP1_2 PF07926.12 EDN08914.1 - 0.094 12.8 75.8 0.2 11.7 32.8 4.3 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein Herpes_IE2_3 PF03361.14 EDN08914.1 - 0.11 12.3 3.3 1.5 8.7 0.4 2.6 2 0 0 2 2 2 0 Herpes virus intermediate/early protein 2/3 Filament PF00038.21 EDN08914.1 - 0.26 10.8 65.3 0.17 11.4 30.1 4.0 1 1 1 3 3 3 0 Intermediate filament protein DUF1664 PF07889.12 EDN08914.1 - 0.27 11.3 41.9 1.1 9.2 8.3 4.4 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) FapA PF03961.13 EDN08914.1 - 0.37 9.3 51.7 0.029 13.0 9.4 3.6 1 1 3 4 4 4 0 Flagellar Assembly Protein A Syntaxin-6_N PF09177.11 EDN08914.1 - 0.44 11.1 41.1 0.4 11.3 11.1 4.3 1 1 3 4 4 4 0 Syntaxin 6, N-terminal AAA_13 PF13166.6 EDN08914.1 - 0.52 8.9 51.3 0.071 11.7 34.9 2.3 1 1 1 2 2 2 0 AAA domain UPF0242 PF06785.11 EDN08914.1 - 0.59 10.2 80.9 0.25 11.4 33.0 4.4 1 1 3 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus Leu_zip PF15294.6 EDN08914.1 - 0.79 9.2 63.6 4.3 6.8 16.8 3.7 1 1 3 4 4 4 0 Leucine zipper EzrA PF06160.12 EDN08914.1 - 0.83 7.8 61.8 1.9 6.6 10.6 3.9 1 1 1 3 3 3 0 Septation ring formation regulator, EzrA MscS_porin PF12795.7 EDN08914.1 - 0.97 8.9 66.4 0.11 12.0 29.9 3.4 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain DUF812 PF05667.11 EDN08914.1 - 1.3 7.8 65.3 0.049 12.5 42.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF3138 PF11336.8 EDN08914.1 - 1.4 7.5 2.4 2.5 6.6 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF4407 PF14362.6 EDN08914.1 - 1.8 7.8 52.4 5.1 6.4 21.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EDN08914.1 - 2 8.6 46.6 0.14 12.3 13.1 3.6 2 1 3 5 5 4 0 Fibrinogen alpha/beta chain family ApoO PF09769.9 EDN08914.1 - 2.1 8.3 18.6 8.3 6.4 2.4 4.3 1 1 2 4 4 3 0 Apolipoprotein O HMMR_N PF15905.5 EDN08914.1 - 2.1 7.7 73.2 3.2 7.1 52.5 3.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Tnp_22_trimer PF17489.2 EDN08914.1 - 3.4 7.7 18.8 0.77 9.8 0.3 5.4 5 0 0 5 5 4 0 L1 transposable element trimerization domain Baculo_PEP_C PF04513.12 EDN08914.1 - 3.6 7.6 30.3 4.5 7.3 2.5 4.1 1 1 2 3 3 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 EDN08914.1 - 4 7.5 45.3 5.8 7.0 10.3 5.3 1 1 4 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 ERM PF00769.19 EDN08914.1 - 6.1 6.6 82.2 2.7 7.7 32.2 3.5 1 1 2 3 3 3 0 Ezrin/radixin/moesin family FliJ PF02050.16 EDN08914.1 - 6.7 7.0 63.5 0.43 10.8 10.4 5.2 2 1 3 5 5 5 0 Flagellar FliJ protein DUF4201 PF13870.6 EDN08914.1 - 7.5 6.2 69.7 7.7 6.2 6.9 5.2 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) GAS PF13851.6 EDN08914.1 - 8.5 5.7 77.0 1.4 8.3 19.1 4.2 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Endotoxin_N PF03945.14 EDN08914.1 - 9 5.9 13.0 0.24 11.1 0.9 2.7 1 1 0 2 2 2 0 delta endotoxin, N-terminal domain SGT1 PF07093.11 EDN08915.1 - 2.1e-91 307.1 4.1 1.3e-80 271.5 0.0 2.0 1 1 1 2 2 2 2 SGT1 protein GFO_IDH_MocA PF01408.22 EDN08916.1 - 8.2e-22 78.3 0.4 1.5e-21 77.4 0.4 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EDN08916.1 - 0.03 14.8 0.0 0.094 13.2 0.0 1.8 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain AMMECR1 PF01871.17 EDN08917.1 - 1.8e-38 131.8 0.0 2.9e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 AMMECR1 Sporozoite_P67 PF05642.11 EDN08917.1 - 0.16 10.0 6.6 0.22 9.6 6.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 EDN08918.1 - 4.3e-71 239.4 0.0 5.4e-71 239.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN08918.1 - 1e-27 97.1 0.0 1.3e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN08918.1 - 4.8e-07 29.4 0.0 7.6e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDN08918.1 - 0.00014 20.7 0.0 0.00024 20.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDN08918.1 - 0.00054 19.9 0.1 0.00076 19.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN08918.1 - 0.00062 19.2 0.1 0.001 18.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1744 PF08490.12 EDN08919.1 - 7.5e-131 436.4 0.4 1.7e-101 339.7 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF1744) DUF4549 PF15082.6 EDN08919.1 - 0.059 13.2 0.3 0.52 10.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4549) DUF1438 PF07270.11 EDN08919.1 - 0.13 12.3 0.6 11 6.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1438) DNA_pol_B_exo1 PF03104.19 EDN08920.1 - 8.4e-73 245.4 1.5 8.4e-73 245.4 1.5 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.9 EDN08920.1 - 2.7e-09 37.0 0.4 7e-09 35.7 0.4 1.6 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EDN08920.1 - 2.5e-05 24.3 0.1 0.00011 22.2 0.1 2.1 1 1 0 1 1 1 1 RNase_H superfamily DUF3767 PF12597.8 EDN08921.1 - 1.9e-12 46.9 0.0 2.5e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) Nop PF01798.18 EDN08922.1 - 1.2e-51 175.4 0.0 1.8e-51 174.8 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDN08923.1 - 7e-16 58.4 0.1 1.4e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Cpn60_TCP1 PF00118.24 EDN08924.1 - 3.4e-163 543.8 0.2 3.8e-163 543.6 0.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MOZ_SAS PF01853.18 EDN08925.1 - 1e-12 48.1 0.0 2.3e-12 46.9 0.0 1.5 1 1 0 1 1 1 1 MOZ/SAS family IF2_N PF04760.15 EDN08925.1 - 0.0095 15.7 0.8 0.062 13.1 0.1 2.1 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region zf-MYST PF17772.1 EDN08926.1 - 1.6e-06 27.6 0.0 2e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 MYST family zinc finger domain RRM_1 PF00076.22 EDN08927.1 - 0.0042 16.9 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_PEP_C PF04513.12 EDN08927.1 - 0.0048 17.0 1.4 0.0066 16.5 0.5 1.7 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus CorA PF01544.18 EDN08927.1 - 0.011 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein tRNA-synt_2 PF00152.20 EDN08928.1 - 3e-63 213.8 0.0 1.5e-49 168.8 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDN08928.1 - 4.7e-07 29.7 0.0 8.2e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain CtsR_C PF17727.1 EDN08928.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 CtsR C-terminal dimerization domain CTX_RstB PF07459.11 EDN08932.1 - 0.077 13.2 0.1 0.092 13.0 0.1 1.1 1 0 0 1 1 1 0 CTX phage RstB protein Gti1_Pac2 PF09729.9 EDN08933.1 - 2.7e-45 154.7 1.1 6.8e-38 130.6 0.1 2.3 1 1 1 2 2 2 2 Gti1/Pac2 family DUF2434 PF10361.9 EDN08934.1 - 3.7e-130 433.2 6.9 5.7e-130 432.6 6.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) DUF2678 PF10856.8 EDN08934.1 - 0.00028 20.8 0.4 0.00028 20.8 0.4 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2678) DKCLD PF08068.12 EDN08934.1 - 0.0022 18.0 0.2 0.017 15.2 0.0 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain Fungal_trans_2 PF11951.8 EDN08936.1 - 8.4e-66 222.3 0.1 1.1e-65 222.0 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Tox-MPTase5 PF15641.6 EDN08937.1 - 0.054 13.5 0.2 0.071 13.2 0.2 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 5 LisH_2 PF16045.5 EDN08937.1 - 0.22 10.6 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 LisH ABC_tran PF00005.27 EDN08938.1 - 1.6e-08 35.2 0.0 2.6e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EDN08938.1 - 1e-06 28.3 1.0 1.4e-06 27.8 1.0 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane PF01061.24 EDN08939.1 - 3.3e-23 82.2 12.8 5.9e-23 81.4 12.8 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EDN08939.1 - 2.4e-20 73.5 0.0 4.5e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDN08939.1 - 6.9e-05 22.8 0.3 0.0046 16.8 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 EDN08939.1 - 0.2 11.6 1.2 0.71 9.8 0.3 2.1 2 0 0 2 2 2 0 NACHT domain Bys1 PF04681.12 EDN08940.1 - 2.7e-08 33.9 0.9 4.8e-08 33.1 0.9 1.3 1 1 0 1 1 1 1 Blastomyces yeast-phase-specific protein AA_permease_2 PF13520.6 EDN08941.1 - 5.2e-38 131.0 36.2 8.9e-37 126.9 20.4 2.1 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EDN08941.1 - 1.9e-10 40.0 23.4 3.4e-09 35.8 13.0 2.2 1 1 1 2 2 2 2 Amino acid permease Lactamase_B_6 PF16661.5 EDN08942.1 - 6.1e-66 221.5 0.0 1.2e-65 220.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EDN08942.1 - 8.9e-49 165.9 0.8 1.4e-48 165.3 0.1 1.7 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.12 EDN08942.1 - 7.7e-15 54.6 0.0 3.6e-14 52.4 0.0 2.1 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp PF10996.8 EDN08942.1 - 0.00029 21.1 0.0 0.0019 18.4 0.0 2.5 3 1 0 3 3 3 1 Beta-Casp domain Lactamase_B PF00753.27 EDN08942.1 - 0.004 17.2 0.0 0.0091 16.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDN08942.1 - 0.071 12.6 0.0 0.51 9.8 0.0 2.2 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Phospholip_B PF04916.13 EDN08944.1 - 0.19 10.3 0.0 0.26 9.8 0.0 1.1 1 0 0 1 1 1 0 Phospholipase B Sec23_trunk PF04811.15 EDN08945.1 - 2.1e-53 181.4 0.0 8e-53 179.5 0.0 1.9 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDN08945.1 - 2.3e-17 62.7 0.0 5.7e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDN08945.1 - 3.9e-14 53.1 0.1 1.5e-13 51.3 0.1 2.0 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EDN08945.1 - 2.7e-06 27.2 0.0 5.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vg_Tdu PF07545.14 EDN08945.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Vestigial/Tondu family zf-C2H2 PF00096.26 EDN08946.1 - 1.3e-05 25.4 12.1 0.0051 17.2 1.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN08946.1 - 0.00024 21.4 3.8 0.00024 21.4 3.8 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN08946.1 - 0.0013 19.4 11.5 0.064 14.1 2.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger TylF PF05711.11 EDN08946.1 - 0.22 10.8 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) zf-H2C2_5 PF13909.6 EDN08946.1 - 7 6.5 7.7 4.9 7.0 1.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain ACC_central PF08326.12 EDN08947.1 - 0.11 10.7 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Acetyl-CoA carboxylase, central region tRNA-synt_1 PF00133.22 EDN08947.1 - 0.12 10.6 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) COG5 PF10392.9 EDN08948.1 - 4.8e-42 143.3 0.0 3.8e-41 140.4 0.0 2.0 3 0 0 3 3 3 1 Golgi transport complex subunit 5 YscO PF07321.12 EDN08948.1 - 0.08 12.9 0.8 0.13 12.2 0.8 1.3 1 0 0 1 1 1 0 Type III secretion protein YscO SYS1 PF09801.9 EDN08949.1 - 9.1e-56 188.0 10.5 1.1e-55 187.8 10.5 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF485 PF04341.12 EDN08949.1 - 2.2 8.3 9.1 0.076 13.0 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF485 RRM_1 PF00076.22 EDN08950.1 - 1.4e-10 40.9 0.0 3.3e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN08950.1 - 9.3e-05 22.0 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RF-1 PF00472.20 EDN08951.1 - 1.8e-16 60.1 0.0 2.9e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 RF-1 domain U3_assoc_6 PF08640.11 EDN08952.1 - 5.9e-28 96.8 5.0 1.7e-27 95.3 0.5 2.6 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EDN08952.1 - 0.0015 19.2 3.7 0.087 13.7 0.2 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDN08952.1 - 0.02 14.1 0.8 0.032 13.4 0.8 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat NRDE-2 PF08424.10 EDN08952.1 - 0.14 11.3 0.4 0.37 9.9 0.3 1.7 1 1 0 1 1 1 0 NRDE-2, necessary for RNA interference Frag1 PF10277.9 EDN08953.1 - 2.1e-42 145.1 5.6 2.5e-42 144.9 5.6 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family AIF-MLS PF14962.6 EDN08955.1 - 0.0053 16.7 0.9 0.0064 16.5 0.9 1.1 1 0 0 1 1 1 1 Mitochondria Localisation Sequence DUF1476 PF07345.11 EDN08955.1 - 0.082 13.3 2.5 0.12 12.7 2.5 1.2 1 0 0 1 1 1 0 ATPase inhibitor subunit zeta CDT1_C PF16679.5 EDN08956.1 - 1.4e-15 57.5 0.0 2.8e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain FAD_binding_3 PF01494.19 EDN08957.1 - 8e-14 51.6 1.1 5.4e-12 45.6 1.1 2.8 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EDN08957.1 - 4.5e-06 25.9 0.1 9.6e-06 24.9 0.1 1.5 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EDN08957.1 - 2.7e-05 23.6 0.0 0.00014 21.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN08957.1 - 2.8e-05 23.5 0.1 0.014 14.7 0.1 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EDN08957.1 - 8.5e-05 22.0 0.4 0.19 10.9 0.0 2.4 2 1 1 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDN08957.1 - 0.00071 19.8 0.0 0.0018 18.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EDN08957.1 - 0.0045 16.1 0.0 0.0082 15.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain TrkA_N PF02254.18 EDN08957.1 - 0.014 15.6 0.0 0.042 14.1 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox PF00070.27 EDN08957.1 - 0.017 15.7 0.0 0.045 14.3 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDN08957.1 - 0.017 14.7 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase ATS PF15445.6 EDN08957.1 - 0.037 13.4 0.1 0.056 12.9 0.1 1.2 1 0 0 1 1 1 0 acidic terminal segments, variant surface antigen of PfEMP1 HI0933_like PF03486.14 EDN08957.1 - 0.04 12.6 0.2 0.18 10.5 0.1 1.8 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EDN08957.1 - 0.048 12.9 0.1 0.083 12.1 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Shikimate_DH PF01488.20 EDN08957.1 - 0.083 13.0 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EDN08957.1 - 0.19 11.1 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MutS_V PF00488.21 EDN08958.1 - 1.1e-81 273.3 0.1 2.1e-81 272.5 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDN08958.1 - 1.8e-37 129.5 1.1 1.8e-37 129.5 1.1 2.3 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 EDN08958.1 - 5.5e-18 65.6 0.0 1.5e-17 64.2 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EDN08958.1 - 8.9e-17 61.2 1.0 2.6e-16 59.8 1.0 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 EDN08958.1 - 6.7e-15 55.3 0.0 5.6e-14 52.3 0.0 2.3 2 0 0 2 2 2 1 MutS domain I AAA_27 PF13514.6 EDN08958.1 - 0.046 13.3 0.1 0.77 9.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Gpi1 PF05024.15 EDN08959.1 - 1.1e-31 110.3 1.7 2.6e-31 109.2 1.7 1.6 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Myb_DNA-bind_6 PF13921.6 EDN08960.1 - 0.0027 17.9 0.0 0.0047 17.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN08960.1 - 0.026 14.7 0.1 0.066 13.4 0.1 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain DUF1657 PF07870.11 EDN08960.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) RcnB PF11776.8 EDN08960.1 - 0.078 13.0 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator UPF0203 PF05254.12 EDN08961.1 - 1.4e-25 89.3 3.9 2.1e-25 88.7 3.9 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 EDN08961.1 - 0.0065 16.8 4.8 0.022 15.1 2.9 2.5 2 1 0 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EDN08961.1 - 0.01 15.9 7.3 0.043 13.9 0.3 2.4 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EDN08961.1 - 0.017 15.1 0.1 0.017 15.1 0.1 2.7 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UCR_hinge PF02320.16 EDN08961.1 - 0.019 15.2 4.2 0.019 15.2 4.2 2.0 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein NDUF_B7 PF05676.13 EDN08961.1 - 0.11 12.3 4.0 3.9 7.3 0.2 2.3 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DNA_pol_A_exo1 PF01612.20 EDN08962.1 - 7.8e-38 129.9 0.4 1.6e-37 128.9 0.4 1.6 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 EDN08962.1 - 2.6e-28 98.5 0.9 2.8e-27 95.2 1.1 2.5 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 EDN08962.1 - 2.9e-10 40.0 0.1 7.9e-10 38.6 0.0 1.8 2 0 0 2 2 2 1 HRDC domain Methyltransf_25 PF13649.6 EDN08963.1 - 5.2e-09 36.7 0.1 2.2e-07 31.5 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN08963.1 - 1.3e-08 35.3 0.1 4.4e-07 30.5 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN08963.1 - 2.5e-05 24.1 0.1 9.5e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN08963.1 - 0.00023 21.8 0.0 0.0019 18.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN08963.1 - 0.00047 20.0 0.0 0.00053 19.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDN08963.1 - 0.19 11.7 0.0 0.32 11.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain CCDC24 PF15669.5 EDN08963.1 - 0.23 11.3 0.6 0.33 10.8 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Chorion_2 PF03964.15 EDN08963.1 - 2.9 8.8 10.0 2 9.3 7.5 2.1 2 1 0 2 2 2 0 Chorion family 2 Croc_4 PF17691.1 EDN08964.1 - 0.067 13.2 0.9 0.069 13.2 0.9 1.3 1 1 0 1 1 1 0 Contingent replication of cDNA 4 RasGAP PF00616.19 EDN08965.1 - 3.3e-59 200.1 0.9 7.3e-59 199.0 0.1 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Fibin PF15819.5 EDN08965.1 - 0.0071 16.1 1.9 0.038 13.7 1.5 2.0 2 0 0 2 2 2 1 Fin bud initiation factor homologue CRAL_TRIO PF00650.20 EDN08966.1 - 2.7e-37 127.9 0.0 4.5e-37 127.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDN08966.1 - 2e-08 34.3 0.2 4.2e-08 33.2 0.2 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDN08966.1 - 0.00032 20.9 0.0 0.00053 20.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Mis14 PF08641.12 EDN08967.1 - 6.6e-22 78.3 0.0 1.9e-21 76.8 0.0 1.8 2 0 0 2 2 2 1 Kinetochore protein Mis14 like RT_RNaseH PF17917.1 EDN08969.1 - 1.9e-35 121.3 0.7 4.6e-35 120.1 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN08969.1 - 1.9e-26 93.0 0.0 3.4e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN08969.1 - 1.4e-22 79.6 0.1 7e-22 77.3 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN08969.1 - 1.4e-19 70.0 2.2 2e-19 69.4 0.3 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EDN08969.1 - 2.8e-12 46.9 0.0 1e-11 45.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN08969.1 - 0.0018 18.4 0.0 0.0042 17.3 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger RVP_2 PF08284.11 EDN08969.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease PPR_2 PF13041.6 EDN08970.1 - 1.8e-05 24.8 0.0 0.004 17.3 0.0 2.4 2 0 0 2 2 2 2 PPR repeat family KH_1 PF00013.29 EDN08970.1 - 3.6e-05 23.5 0.0 6.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 KH domain PPR PF01535.20 EDN08970.1 - 0.015 15.5 0.1 0.04 14.2 0.1 1.8 1 0 0 1 1 1 0 PPR repeat PPR_3 PF13812.6 EDN08970.1 - 0.046 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Pentatricopeptide repeat domain Acetyltransf_1 PF00583.25 EDN08971.1 - 1.7e-11 44.4 0.1 4.1e-09 36.7 0.1 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN08971.1 - 1.5e-09 38.1 0.1 2.3e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDN08971.1 - 2.5e-07 30.7 0.0 1.8e-05 24.7 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN08971.1 - 1.3e-05 25.0 0.3 0.0084 16.0 0.3 2.3 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EDN08971.1 - 0.023 14.4 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDN08971.1 - 0.024 15.3 0.0 3.2 8.4 0.0 2.2 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDN08971.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase LCAT PF02450.15 EDN08972.1 - 8.9e-107 357.6 0.0 1.1e-106 357.4 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EDN08972.1 - 0.0013 19.4 0.0 0.0023 18.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EDN08972.1 - 0.029 13.9 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Lipase_2 PF01674.18 EDN08972.1 - 0.035 13.6 0.0 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 2) DUF1749 PF08538.10 EDN08972.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) PAP2_3 PF14378.6 EDN08973.1 - 1.5e-24 86.8 9.8 1.5e-24 86.8 9.8 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EDN08973.1 - 7e-10 38.8 3.9 7e-10 38.8 3.9 2.1 2 0 0 2 2 2 1 PAP2 superfamily Sugar_tr PF00083.24 EDN08976.1 - 1.9e-19 69.9 8.6 6e-09 35.3 0.1 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDN08976.1 - 5.6e-18 65.0 28.2 5.8e-16 58.4 11.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1275 PF06912.11 EDN08976.1 - 0.62 10.0 9.9 0.86 9.5 1.7 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1275) gag_pre-integrs PF13976.6 EDN08977.1 - 8.9e-13 47.9 0.2 2.1e-12 46.7 0.2 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_2 PF07727.14 EDN08977.1 - 2.7e-10 40.3 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 4F5 PF04419.14 EDN08978.1 - 1.8 9.5 12.7 18 6.3 12.7 2.5 1 1 0 1 1 1 0 4F5 protein family PAP_PilO PF06864.12 EDN08979.1 - 0.03 13.2 0.1 0.033 13.0 0.1 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Wzy_C PF04932.15 EDN08979.1 - 0.033 13.8 0.1 0.041 13.5 0.1 1.0 1 0 0 1 1 1 0 O-Antigen ligase DUF2681 PF10883.8 EDN08979.1 - 0.096 13.1 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) S1FA PF04689.13 EDN08979.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 DNA binding protein S1FA Tad PF13400.6 EDN08979.1 - 0.21 11.9 3.5 0.34 11.3 3.5 1.3 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like DUF4307 PF14155.6 EDN08979.1 - 1 9.2 5.0 4.8 7.1 4.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) DUF1768 PF08719.11 EDN08981.1 - 8e-56 188.7 0.0 9.1e-56 188.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) HNH_2 PF13391.6 EDN08983.1 - 0.0059 16.7 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease zf-HC2 PF13490.6 EDN08983.1 - 2.1 8.7 7.1 0.23 11.8 0.6 2.6 3 0 0 3 3 3 0 Putative zinc-finger DUF2306 PF10067.9 EDN08984.1 - 1.9e-13 50.9 7.0 1.9e-13 50.9 7.0 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) PHO4 PF01384.20 EDN08984.1 - 0.018 14.1 1.4 0.026 13.6 1.4 1.2 1 0 0 1 1 1 0 Phosphate transporter family Cation_efflux PF01545.21 EDN08986.1 - 1.3e-23 83.8 3.8 2.4e-15 56.8 0.0 2.0 2 0 0 2 2 2 2 Cation efflux family DUF2370 PF10176.9 EDN08986.1 - 0.056 13.1 0.1 2.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) FAM176 PF14851.6 EDN08986.1 - 0.14 11.8 1.0 0.24 11.1 0.1 1.8 2 1 0 2 2 2 0 FAM176 family AMPK1_CBM PF16561.5 EDN08988.1 - 6e-07 29.6 0.0 9.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 EDN08988.1 - 0.036 14.4 0.0 0.084 13.2 0.0 1.6 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) cNMP_binding PF00027.29 EDN08989.1 - 1.9e-20 72.7 0.0 2.9e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Forkhead PF00250.18 EDN08991.1 - 2e-17 63.2 0.0 4e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EDN08991.1 - 2.8e-05 24.4 0.0 6.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain Snf7 PF03357.21 EDN08992.1 - 2.6e-35 121.5 17.3 2.6e-35 121.5 17.3 2.0 2 0 0 2 2 2 1 Snf7 CPSase_L_D3 PF02787.19 EDN08992.1 - 0.23 11.8 3.5 0.2 12.0 1.6 2.0 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Peptidase_S46 PF10459.9 EDN08992.1 - 0.31 9.6 10.5 0.33 9.5 10.5 1.1 1 0 0 1 1 1 0 Peptidase S46 Ribosomal_60s PF00428.19 EDN08992.1 - 0.51 11.0 9.6 0.072 13.7 4.7 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein BLOC1_2 PF10046.9 EDN08992.1 - 1.6 9.1 12.2 2.4 8.5 6.3 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3138 PF11336.8 EDN08992.1 - 1.6 7.2 9.3 0.99 7.9 7.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) TRAF_BIRC3_bd PF16673.5 EDN08992.1 - 2.2 8.2 7.7 0.25 11.2 0.4 2.7 2 1 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Ten1 PF12658.7 EDN08993.1 - 1.8e-50 169.9 0.0 2.1e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 EDN08993.1 - 0.0028 17.4 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit MFS_1 PF07690.16 EDN08994.1 - 2.5e-26 92.4 26.7 3.5e-24 85.4 15.5 2.9 1 1 2 3 3 3 3 Major Facilitator Superfamily Kelch_5 PF13854.6 EDN08995.1 - 9.6e-18 63.8 14.4 4.8e-07 29.6 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 EDN08995.1 - 4.2e-09 36.4 8.1 0.21 11.9 0.1 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EDN08995.1 - 1.1e-08 35.1 9.8 0.46 10.8 0.4 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EDN08995.1 - 2.3e-08 33.5 7.0 0.058 13.0 0.2 5.0 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EDN08995.1 - 3e-08 33.5 11.4 0.016 15.2 0.1 5.8 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EDN08995.1 - 1.7e-07 31.0 3.8 0.1 12.6 0.0 4.8 4 0 0 4 4 4 2 Kelch motif SKG6 PF08693.10 EDN08995.1 - 0.0001 21.6 1.4 0.00024 20.4 1.4 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain BCAS2 PF05700.11 EDN08997.1 - 1e-68 231.1 2.5 1.2e-68 230.9 2.5 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Ceramidase_alk PF04734.13 EDN08998.1 - 1.9e-192 640.5 0.0 2.4e-192 640.1 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EDN08998.1 - 9.1e-56 188.3 0.1 1.4e-55 187.7 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal EI24 PF07264.11 EDN09000.1 - 3.2e-15 56.8 2.0 3.9e-15 56.5 1.2 1.5 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DC_STAMP PF07782.13 EDN09000.1 - 0.44 10.3 2.7 2.6 7.8 0.1 2.2 2 0 0 2 2 2 0 DC-STAMP-like protein HAD_2 PF13419.6 EDN09001.1 - 2.8e-10 40.6 0.0 3.6e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN09001.1 - 0.00029 20.8 0.0 0.00047 20.2 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDN09001.1 - 0.0067 16.7 0.0 0.056 13.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase GTP_EFTU PF00009.27 EDN09003.1 - 3.6e-33 114.8 5.0 2.3e-31 108.9 5.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDN09003.1 - 5.3e-30 103.7 0.9 1.1e-29 102.6 0.1 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 IF2_N PF04760.15 EDN09003.1 - 1.7e-11 43.8 0.0 4.6e-11 42.4 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 EDN09003.1 - 3e-10 40.2 0.2 8.2e-10 38.8 0.2 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EDN09003.1 - 1.1e-05 25.7 4.4 0.085 13.3 0.2 3.3 3 0 0 3 3 3 2 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EDN09003.1 - 1.2e-05 25.2 3.4 0.00031 20.7 0.5 2.5 1 1 1 2 2 2 1 RsgA GTPase Arf PF00025.21 EDN09003.1 - 9.4e-05 21.9 0.3 0.0002 20.9 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 EDN09003.1 - 0.00044 19.7 0.0 0.0011 18.5 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDN09003.1 - 0.016 14.7 0.8 0.051 13.1 0.8 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EDN09003.1 - 0.023 14.5 0.2 0.096 12.4 0.2 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 EDN09003.1 - 0.032 13.8 0.1 0.063 12.9 0.1 1.5 1 0 0 1 1 1 0 Ras family Roc PF08477.13 EDN09003.1 - 0.036 14.3 0.0 0.099 12.9 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EDN09003.1 - 0.072 13.1 0.7 13 5.8 0.0 2.9 2 1 1 3 3 3 0 Dynamin family SIS_2 PF13580.6 EDN09003.1 - 0.12 12.4 1.0 12 6.0 0.2 2.8 2 1 0 2 2 2 0 SIS domain Mito_carr PF00153.27 EDN09004.1 - 2.2e-59 197.4 1.5 7.3e-20 70.7 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_S2 PF00318.20 EDN09006.1 - 6.1e-68 228.3 0.1 1.6e-66 223.6 0.1 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 NACHT PF05729.12 EDN09007.1 - 1.2e-09 38.3 0.0 3e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EDN09007.1 - 6.3e-08 33.2 0.1 2.1e-07 31.5 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain APS_kinase PF01583.20 EDN09007.1 - 0.00078 19.4 0.1 0.0016 18.4 0.1 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase NB-ARC PF00931.22 EDN09007.1 - 0.0025 17.1 0.2 0.0096 15.1 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 EDN09007.1 - 0.0031 17.8 0.3 0.11 12.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EDN09007.1 - 0.0043 17.2 0.1 0.051 13.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EDN09007.1 - 0.02 15.3 0.4 0.072 13.5 0.1 2.3 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EDN09007.1 - 0.021 14.5 2.2 1.6 8.5 0.1 3.2 3 0 0 3 3 3 0 Cytidylate kinase AAA_18 PF13238.6 EDN09007.1 - 0.042 14.4 0.0 0.24 11.9 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDN09007.1 - 0.042 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDN09007.1 - 0.053 13.4 0.0 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 NTPase RNA_helicase PF00910.22 EDN09007.1 - 0.06 13.7 0.1 0.44 11.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF746 PF05344.11 EDN09007.1 - 0.15 11.9 0.2 0.51 10.2 0.2 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) Apt1 PF10351.9 EDN09007.1 - 1.2 8.0 6.5 1.9 7.2 6.5 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pkinase_fungal PF17667.1 EDN09008.1 - 1.9e-130 435.3 0.1 3.5e-130 434.5 0.1 1.4 1 1 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN09008.1 - 0.0077 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SURF6 PF04935.12 EDN09009.1 - 6.1e-50 169.8 32.2 6.1e-50 169.8 32.2 4.7 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 EDN09009.1 - 6e-18 65.2 0.7 6e-18 65.2 0.7 9.0 7 2 0 7 7 7 1 60S ribosome biogenesis protein Rrp14 Fer4 PF00037.27 EDN09010.1 - 4.9e-13 48.3 16.2 6e-08 32.2 3.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EDN09010.1 - 2.8e-12 47.0 9.0 4.2e-12 46.5 9.0 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EDN09010.1 - 2.8e-09 37.8 6.7 7.1e-05 23.7 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EDN09010.1 - 4.7e-09 36.2 4.6 0.00078 19.5 0.3 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDN09010.1 - 1.9e-08 34.3 20.8 3.4e-06 27.1 11.7 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDN09010.1 - 2.8e-08 33.8 8.0 4.8e-08 33.1 8.0 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDN09010.1 - 8.8e-08 32.5 17.8 3.5e-05 24.2 10.2 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EDN09010.1 - 4.7e-06 26.4 11.8 0.0096 16.0 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EDN09010.1 - 6.7e-06 26.2 10.2 0.0003 21.1 1.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 EDN09010.1 - 2.5e-05 24.1 16.4 0.0067 16.5 4.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EDN09010.1 - 0.00042 20.8 11.3 0.023 15.2 12.0 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EDN09010.1 - 0.023 14.9 5.2 1.4 9.2 0.3 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_13 PF13370.6 EDN09010.1 - 0.025 15.1 14.0 0.32 11.6 3.6 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EDN09010.1 - 0.079 13.2 8.5 1.3 9.2 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EDN09010.1 - 0.17 12.9 14.7 0.42 11.7 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 EDN09010.1 - 0.34 11.8 10.8 2.8 8.9 1.7 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 EDN09010.1 - 0.97 9.6 5.4 1.3 9.2 0.7 2.1 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_15 PF13459.6 EDN09010.1 - 3.5 8.4 11.5 25 5.7 4.1 2.9 2 1 0 2 2 2 0 4Fe-4S single cluster domain Lar_restr_allev PF14354.6 EDN09010.1 - 4.8 7.6 7.6 5.3e+02 1.1 7.6 2.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar PP-binding PF00550.25 EDN09011.1 - 2.7e-10 40.5 0.3 3.7e-10 40.0 0.3 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EDN09011.1 - 0.00013 22.1 0.2 0.0002 21.5 0.2 1.3 1 0 0 1 1 1 1 Acyl-carrier GPP34 PF05719.11 EDN09012.1 - 6.5e-66 222.2 0.0 8.3e-66 221.9 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) ADH_zinc_N_2 PF13602.6 EDN09013.1 - 4.7e-18 66.5 0.1 7.9e-18 65.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDN09013.1 - 1.8e-07 31.2 0.3 9.9e-07 28.8 0.3 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN09013.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.7 1 1 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DUF2183 PF09949.9 EDN09014.1 - 1.8e-35 121.2 0.0 2.8e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) adh_short PF00106.25 EDN09015.1 - 1e-17 64.3 0.0 6.1e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDN09015.1 - 3.2e-09 36.7 0.0 1.5e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN09015.1 - 0.00018 21.5 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EDN09015.1 - 0.022 14.1 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 EDN09015.1 - 0.046 13.2 0.0 0.14 11.6 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Phytase PF02333.15 EDN09016.1 - 3.7e-22 78.8 0.6 1.7e-19 70.0 0.0 3.0 3 0 0 3 3 3 2 Phytase EGF_2 PF07974.13 EDN09016.1 - 1e-05 25.8 12.7 1e-05 25.8 12.7 2.5 2 0 0 2 2 2 1 EGF-like domain EGF_Tenascin PF18720.1 EDN09016.1 - 0.89 9.7 8.0 2.5 8.2 8.0 1.8 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 EDN09016.1 - 1.4 9.6 5.2 4.2 8.2 5.2 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Peptidase_M43 PF05572.13 EDN09017.1 - 0.066 13.1 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A CBS PF00571.28 EDN09019.1 - 7.4e-16 58.3 3.7 2e-05 25.0 0.0 4.8 5 0 0 5 5 5 4 CBS domain Spt20 PF12090.8 EDN09020.1 - 0.58 9.7 13.7 1.4 8.5 13.7 1.8 1 0 0 1 1 1 0 Spt20 family VHS PF00790.19 EDN09022.1 - 1.6e-46 157.7 0.0 5.6e-46 155.9 0.0 1.9 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EDN09022.1 - 3e-22 78.7 0.3 3e-22 78.7 0.3 2.7 3 0 0 3 3 3 1 GAT domain Alpha_adaptinC2 PF02883.20 EDN09022.1 - 1.3e-18 67.4 0.1 3.9e-18 65.8 0.1 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EDN09022.1 - 8.1e-10 38.2 0.2 6.5e-07 28.9 0.0 3.3 3 0 0 3 3 3 2 GGA N-GAT domain DUF5344 PF17279.2 EDN09022.1 - 0.012 16.2 1.0 0.26 11.9 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Ribo_biogen_C PF04034.13 EDN09023.1 - 1.8e-51 173.1 0.1 2.6e-51 172.7 0.1 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EDN09023.1 - 4.1e-10 39.3 0.7 4.1e-10 39.3 0.7 1.6 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI Cpn60_TCP1 PF00118.24 EDN09025.1 - 4.1e-39 134.5 0.0 5.1e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pyr_redox_2 PF07992.14 EDN09025.1 - 0.1 11.8 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Cpn60_TCP1 PF00118.24 EDN09026.1 - 7.2e-92 308.5 2.5 6.8e-91 305.3 2.5 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Peptidase_C14 PF00656.22 EDN09027.1 - 8.7e-62 209.3 0.0 1.1e-61 209.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain F-box-like PF12937.7 EDN09028.1 - 5.5e-06 26.2 0.3 1.7e-05 24.6 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EDN09028.1 - 0.001 18.6 0.4 0.0035 16.9 0.4 1.9 1 0 0 1 1 1 1 F-box F-box PF00646.33 EDN09028.1 - 0.0017 18.2 1.0 0.0098 15.8 0.1 2.7 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.7 EDN09028.1 - 0.0048 17.3 5.1 2.3 8.8 0.0 5.0 4 1 3 7 7 7 1 Leucine Rich repeats (2 copies) CCDC24 PF15669.5 EDN09028.1 - 0.77 9.6 2.9 1.8 8.4 2.9 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Ribosomal_S26e PF01283.19 EDN09029.1 - 1.3e-51 173.6 8.1 1.5e-51 173.3 8.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EDN09029.1 - 0.024 14.6 0.5 0.055 13.4 0.0 1.8 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EDN09029.1 - 0.072 12.9 0.4 0.12 12.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) CBS PF00571.28 EDN09030.1 - 1.6e-36 124.5 2.7 2.4e-09 37.5 0.0 4.4 4 0 0 4 4 4 4 CBS domain Importin_rep_4 PF18808.1 EDN09031.1 - 4.9e-32 110.1 2.7 1.8e-30 105.1 0.7 3.9 3 1 1 4 4 4 1 Importin repeat HEAT_EZ PF13513.6 EDN09031.1 - 2e-18 66.5 13.2 2.8e-08 34.1 0.3 7.6 7 1 1 8 8 8 3 HEAT-like repeat Importin_rep_5 PF18816.1 EDN09031.1 - 1.7e-17 63.5 5.2 4.4e-09 36.5 0.3 2.9 2 0 0 2 2 2 2 Importin repeat HEAT PF02985.22 EDN09031.1 - 1.2e-15 56.2 7.3 0.0053 16.9 0.0 11.0 11 0 0 11 11 11 2 HEAT repeat HEAT_2 PF13646.6 EDN09031.1 - 8e-14 51.8 8.1 9.7e-05 22.7 0.0 7.5 4 2 2 7 7 7 3 HEAT repeats Importin_rep_6 PF18829.1 EDN09031.1 - 7.4e-12 45.4 1.2 1.1e-10 41.6 0.2 3.1 3 0 0 3 3 3 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 EDN09031.1 - 2.5e-09 37.6 0.3 0.16 12.6 0.0 6.3 4 2 3 7 7 6 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EDN09031.1 - 4.1e-08 33.3 0.2 0.017 15.0 0.0 5.4 4 2 1 6 6 6 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 EDN09031.1 - 3.4e-07 29.7 3.8 1.7e-05 24.1 0.2 4.1 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 EDN09031.1 - 6.1e-06 26.4 0.1 0.0094 16.0 0.0 5.0 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EDN09031.1 - 4.5e-05 23.3 0.0 0.00048 19.9 0.0 2.8 1 1 1 2 2 2 1 rRNA processing/ribosome biogenesis IBN_N PF03810.19 EDN09031.1 - 0.00027 20.8 0.1 0.0035 17.2 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain CLASP_N PF12348.8 EDN09031.1 - 0.00027 20.6 1.7 0.13 11.8 0.1 4.7 6 1 2 8 8 7 1 CLASP N terminal Arm PF00514.23 EDN09031.1 - 0.0011 18.9 3.0 1.9 8.7 0.0 4.4 4 0 0 4 4 3 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EDN09031.1 - 0.0037 15.9 0.1 0.01 14.4 0.1 1.8 1 0 0 1 1 1 1 Adaptin N terminal region DUF4042 PF13251.6 EDN09031.1 - 0.0047 16.7 0.1 3.7 7.2 0.0 4.4 3 1 0 4 4 4 1 Domain of unknown function (DUF4042) UNC45-central PF11701.8 EDN09031.1 - 0.0088 16.0 1.3 2.2 8.2 0.1 3.6 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 EDN09031.1 - 0.013 15.6 0.1 0.44 10.8 0.1 3.3 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DRIM PF07539.12 EDN09031.1 - 0.014 13.8 3.5 0.051 11.9 0.4 3.3 3 1 2 5 5 5 0 Down-regulated in metastasis TFCD_C PF12612.8 EDN09031.1 - 0.062 13.1 0.5 12 5.7 0.0 3.5 3 1 1 4 4 4 0 Tubulin folding cofactor D C terminal DALR_1 PF05746.15 EDN09031.1 - 0.17 12.1 2.1 3 8.0 0.5 3.3 3 0 0 3 3 3 0 DALR anticodon binding domain Telomere_reg-2 PF10193.9 EDN09031.1 - 0.22 12.0 3.7 0.42 11.1 0.4 3.2 3 0 0 3 3 3 0 Telomere length regulation protein Aconitase_C PF00694.19 EDN09032.1 - 3e-39 134.3 0.0 4.6e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase PF00330.20 EDN09032.1 - 4.5e-31 108.4 0.1 5.8e-31 108.0 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF2408 PF10303.9 EDN09033.1 - 8e-39 133.3 7.3 6.7e-29 101.2 0.0 4.1 3 1 0 3 3 3 2 Protein of unknown function (DUF2408) Josephin PF02099.17 EDN09033.1 - 0.11 12.6 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Josephin RsbRD_N PF14361.6 EDN09033.1 - 0.27 11.9 2.0 2.5 8.8 2.0 2.7 1 1 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain KxDL PF10241.9 EDN09033.1 - 0.58 10.5 4.1 11 6.3 0.3 3.7 2 1 1 3 3 3 0 Uncharacterized conserved protein Ribosomal_60s PF00428.19 EDN09034.1 - 4e-24 85.0 6.4 4.8e-24 84.8 6.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Glyco_transf_21 PF13506.6 EDN09034.1 - 0.12 11.8 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 21 PQ-loop PF04193.14 EDN09035.1 - 2.1e-19 69.0 1.7 2.1e-19 69.0 1.7 2.6 2 0 0 2 2 2 1 PQ loop repeat Tcf25 PF04910.14 EDN09036.1 - 2.1e-58 198.1 0.0 3.3e-58 197.4 0.0 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_2 PF07719.17 EDN09036.1 - 0.00024 21.0 0.7 0.094 12.9 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 EDN09036.1 - 0.00071 20.0 0.1 0.18 12.5 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDN09036.1 - 0.0068 16.7 0.1 4.5 7.6 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat Stm1_N PF09598.10 EDN09036.1 - 0.0076 17.1 3.8 0.0076 17.1 3.8 2.0 2 0 0 2 2 2 1 Stm1 TPR_8 PF13181.6 EDN09036.1 - 0.02 15.1 0.1 7.8 7.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN09036.1 - 0.09 13.5 0.6 0.78 10.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN09036.1 - 0.11 12.7 0.0 4.2 7.7 0.1 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EDN09036.1 - 0.14 13.1 0.3 17 6.6 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDN09036.1 - 0.18 11.7 0.5 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat PP2C PF00481.21 EDN09037.1 - 3.8e-42 144.7 0.0 6.4e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EDN09037.1 - 4.1e-05 23.3 0.1 8e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EDN09037.1 - 0.04 13.8 0.1 2.7 7.9 0.0 2.6 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) zf-C2H2 PF00096.26 EDN09038.1 - 2.8e-12 46.3 14.8 5.3e-06 26.6 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN09038.1 - 1.1e-11 44.6 11.9 2.4e-07 30.8 0.2 4.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDN09038.1 - 5.9e-08 32.5 5.7 0.00034 20.5 0.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDN09038.1 - 2.8e-07 30.8 15.9 0.00065 20.3 1.6 4.3 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDN09038.1 - 0.0011 19.1 10.4 0.24 11.7 0.1 4.7 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDN09038.1 - 0.0016 18.7 6.4 0.014 15.8 0.3 3.4 4 0 0 4 4 3 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EDN09038.1 - 0.076 13.3 1.3 0.16 12.3 1.3 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 EDN09038.1 - 0.076 12.8 5.9 1.8 8.4 1.0 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn_ribbon_recom PF13408.6 EDN09038.1 - 0.087 13.3 0.8 0.24 11.9 0.8 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain LIM PF00412.22 EDN09038.1 - 0.24 11.6 2.8 12 6.2 0.1 2.5 1 1 0 2 2 2 0 LIM domain SUIM_assoc PF16619.5 EDN09038.1 - 0.74 9.9 10.4 0.21 11.6 6.5 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 FYVE PF01363.21 EDN09038.1 - 4.7 7.4 6.4 11 6.2 6.4 1.6 1 0 0 1 1 1 0 FYVE zinc finger C5HCH PF17982.1 EDN09038.1 - 8.1 6.7 6.9 39 4.5 1.0 2.6 1 1 1 2 2 2 0 NSD Cys-His rich domain ALG11_N PF15924.5 EDN09039.1 - 2.3e-78 263.0 0.0 3.2e-78 262.6 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EDN09039.1 - 6.8e-19 68.1 0.0 1.1e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDN09039.1 - 7.2e-10 39.4 0.0 1.2e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 DNA_ligase_aden PF01653.18 EDN09039.1 - 0.17 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain Toxin_4 PF00706.17 EDN09039.1 - 0.22 12.0 0.3 2.8 8.4 0.1 2.7 3 0 0 3 3 3 0 Anenome neurotoxin M20_dimer PF07687.14 EDN09041.1 - 1.2e-14 54.2 0.1 2.1e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EDN09041.1 - 1.4e-10 41.2 0.1 2.5e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Pkinase PF00069.25 EDN09042.1 - 9.1e-34 117.0 0.0 1.5e-33 116.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09042.1 - 8.2e-14 51.5 0.0 8.3e-13 48.2 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN09042.1 - 3.8e-05 23.2 0.0 9e-05 21.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDN09042.1 - 0.00038 19.3 0.0 0.00086 18.2 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDN09042.1 - 0.017 15.1 1.3 0.024 14.6 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDN09043.1 - 8.3e-05 22.1 0.2 0.00011 21.7 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09043.1 - 0.22 10.8 0.1 0.32 10.2 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase CDC73_N PF16050.5 EDN09044.1 - 0.86 8.9 6.3 1.3 8.2 6.3 1.2 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal Chorismate_synt PF01264.21 EDN09047.1 - 1.2e-138 461.3 0.0 1.4e-138 461.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ima1_N PF09779.9 EDN09048.1 - 3e-37 128.5 3.4 3e-37 128.5 3.4 2.5 3 0 0 3 3 3 1 Ima1 N-terminal domain Zn_Tnp_IS1595 PF12760.7 EDN09048.1 - 0.0097 15.9 2.6 0.03 14.3 2.6 1.8 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DZR PF12773.7 EDN09048.1 - 1.2 9.2 3.8 6.8 6.8 0.1 2.5 2 0 0 2 2 2 0 Double zinc ribbon DUF2516 PF10724.9 EDN09048.1 - 4.3 7.7 6.3 3.3 8.1 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) Alg14 PF08660.11 EDN09049.1 - 2.2e-50 171.0 0.0 2.2e-34 118.9 0.0 2.2 2 0 0 2 2 2 2 Oligosaccharide biosynthesis protein Alg14 like DUF3176 PF11374.8 EDN09051.1 - 8.1e-30 103.2 0.2 8.1e-30 103.2 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) DUF2721 PF11026.8 EDN09051.1 - 0.14 12.1 1.1 5.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) PNK3P PF08645.11 EDN09052.1 - 3.7e-53 179.5 0.0 5.9e-53 178.9 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Med18 PF09637.10 EDN09052.1 - 3.5e-39 135.1 0.0 1.6e-38 133.0 0.0 2.0 1 1 0 1 1 1 1 Med18 protein AAA_33 PF13671.6 EDN09052.1 - 1.4e-11 44.8 0.0 8.4e-11 42.2 0.0 2.4 3 1 1 4 4 4 1 AAA domain S36_mt PF10937.8 EDN09053.1 - 4.4e-41 141.1 0.2 5.1e-41 140.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF647 PF04884.14 EDN09054.1 - 2e-29 102.9 1.5 4.1e-21 75.7 0.5 2.2 2 0 0 2 2 2 2 Vitamin B6 photo-protection and homoeostasis Mntp PF02659.15 EDN09054.1 - 0.071 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative manganese efflux pump U1snRNP70_N PF12220.8 EDN09054.1 - 0.15 12.7 0.0 0.32 11.7 0.0 1.5 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RGS PF00615.19 EDN09055.1 - 8.7e-13 48.6 0.0 1.4e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain ApoO PF09769.9 EDN09055.1 - 0.079 12.9 0.0 0.54 10.2 0.0 2.1 2 0 0 2 2 2 0 Apolipoprotein O Aegerolysin PF06355.13 EDN09057.1 - 0.00012 22.1 0.0 0.00015 21.8 0.0 1.1 1 0 0 1 1 1 1 Aegerolysin Pkinase PF00069.25 EDN09058.1 - 2.3e-18 66.5 0.1 5.3e-18 65.3 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09058.1 - 9.4e-08 31.6 0.1 3.4e-07 29.8 0.0 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN09058.1 - 2.8e-07 29.7 0.0 3.7e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Rtt106 PF08512.12 EDN09059.1 - 4.3e-29 100.8 0.0 1.9e-28 98.7 0.0 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like PH_18 PF18469.1 EDN09059.1 - 0.0031 17.5 0.0 0.0091 16.0 0.0 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain KOW PF00467.29 EDN09060.1 - 0.023 14.7 1.4 0.023 14.7 1.4 2.0 2 0 0 2 2 2 0 KOW motif Ras PF00071.22 EDN09061.1 - 1.7e-55 187.1 0.0 1.9e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN09061.1 - 2.9e-22 79.1 0.0 4.1e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN09061.1 - 3.1e-06 26.8 0.0 5.1e-06 26.1 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDN09061.1 - 0.0019 17.7 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDN09061.1 - 0.16 11.3 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF1712 PF08217.11 EDN09062.1 - 1.4e-15 56.8 0.1 2.2e-14 52.9 0.0 2.5 2 1 0 2 2 2 1 Fungal domain of unknown function (DUF1712) EMP24_GP25L PF01105.24 EDN09064.1 - 1.2e-25 90.5 0.0 1.6e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD BACON PF13004.7 EDN09064.1 - 0.43 10.6 1.8 11 6.1 0.2 3.1 3 1 0 3 3 3 0 Putative binding domain, N-terminal SANT_DAMP1_like PF16282.5 EDN09065.1 - 1.6e-31 108.4 3.3 3.3e-31 107.3 3.3 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 EDN09065.1 - 0.0026 17.7 7.7 0.0026 17.7 7.7 3.5 1 1 1 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.31 EDN09065.1 - 0.021 15.0 0.0 0.066 13.4 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN09065.1 - 0.034 14.4 0.0 0.077 13.3 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Meth_synt_2 PF01717.18 EDN09066.1 - 2.3e-153 510.2 0.0 4.3e-149 496.1 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EDN09066.1 - 1.6e-109 366.2 0.0 1.5e-103 346.6 0.0 2.5 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain Steroid_dh PF02544.16 EDN09067.1 - 2.9e-11 43.6 4.4 1.7e-07 31.4 1.2 3.7 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EDN09067.1 - 0.044 13.3 0.8 0.091 12.3 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) Ufd2P_core PF10408.9 EDN09068.1 - 4.6e-197 656.5 10.3 7.1e-169 563.4 7.3 2.1 1 1 1 2 2 2 2 Ubiquitin elongating factor core U-box PF04564.15 EDN09068.1 - 4.1e-28 97.4 0.6 1.4e-27 95.6 0.6 2.0 1 0 0 1 1 1 1 U-box domain HDV_ag PF01517.18 EDN09068.1 - 0.19 11.5 0.5 0.41 10.4 0.5 1.4 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen DUF1676 PF07898.13 EDN09068.1 - 0.2 11.7 0.6 0.44 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DivIC PF04977.15 EDN09068.1 - 0.27 11.0 7.2 4.6 7.1 0.1 3.1 3 0 0 3 3 3 0 Septum formation initiator YabA PF06156.13 EDN09068.1 - 2 9.1 4.9 11 6.7 0.3 3.3 3 0 0 3 3 3 0 Initiation control protein YabA DUF1977 PF09320.11 EDN09069.1 - 9.1e-30 103.0 0.0 1.5e-29 102.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EDN09069.1 - 2.1e-22 79.0 0.2 3.5e-22 78.3 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain CTP_transf_like PF01467.26 EDN09071.1 - 1.4e-05 25.3 0.1 4.8e-05 23.6 0.0 2.0 3 0 0 3 3 3 1 Cytidylyltransferase-like Plasmodium_HRP PF05403.11 EDN09073.1 - 4.9e-06 26.5 0.6 7.1e-06 26.0 0.6 1.1 1 0 0 1 1 1 1 Plasmodium histidine-rich protein (HRPII/III) CCSAP PF15748.5 EDN09073.1 - 0.0042 17.3 7.4 0.0062 16.7 7.4 1.4 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated DDHD PF02862.17 EDN09073.1 - 0.0099 16.1 2.7 0.014 15.6 2.7 1.3 1 0 0 1 1 1 1 DDHD domain Neur_chan_memb PF02932.16 EDN09073.1 - 0.083 12.9 1.1 0.097 12.7 1.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spore_coat_CotO PF14153.6 EDN09073.1 - 0.11 12.4 18.5 0.15 11.9 18.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO RIFIN PF02009.16 EDN09073.1 - 0.13 12.1 4.4 0.17 11.7 4.4 1.1 1 0 0 1 1 1 0 Rifin NPR3 PF03666.13 EDN09073.1 - 0.15 10.8 4.3 0.18 10.5 4.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 VIR_N PF15912.5 EDN09073.1 - 0.16 11.6 8.3 0.26 10.8 8.3 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal GNT-I PF03071.15 EDN09073.1 - 0.24 10.1 2.1 0.32 9.7 2.1 1.1 1 0 0 1 1 1 0 GNT-I family TERB2 PF15101.6 EDN09073.1 - 0.26 11.3 6.9 0.42 10.6 6.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TP53IP5 PF15331.6 EDN09073.1 - 0.3 11.2 7.6 0.44 10.7 7.6 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 SAPS PF04499.15 EDN09073.1 - 0.34 9.6 5.1 0.39 9.5 5.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SpoIIP PF07454.11 EDN09073.1 - 0.51 9.8 9.3 0.71 9.3 9.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 EDN09073.1 - 0.53 9.0 8.9 0.77 8.5 8.9 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Suf PF05843.14 EDN09073.1 - 0.63 10.0 7.4 0.89 9.5 7.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PPP4R2 PF09184.11 EDN09073.1 - 0.72 9.4 10.7 1.1 8.8 10.7 1.2 1 0 0 1 1 1 0 PPP4R2 Connexin PF00029.19 EDN09073.1 - 0.76 9.5 3.8 1.1 9.0 3.8 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 EDN09073.1 - 0.86 8.3 14.8 1.3 7.7 14.8 1.2 1 0 0 1 1 1 0 Presenilin eIF3_subunit PF08597.10 EDN09073.1 - 1.4 8.8 19.8 1.9 8.3 19.8 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Raftlin PF15250.6 EDN09073.1 - 1.4 7.6 9.6 1.8 7.2 9.6 1.1 1 0 0 1 1 1 0 Raftlin Paf1 PF03985.13 EDN09073.1 - 1.4 7.8 20.3 2 7.4 20.3 1.1 1 0 0 1 1 1 0 Paf1 DUF4746 PF15928.5 EDN09073.1 - 1.5 8.1 14.3 2.2 7.6 14.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 EDN09073.1 - 1.7 7.5 6.3 2.3 7.1 6.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) GREB1 PF15782.5 EDN09073.1 - 1.7 5.7 6.4 2 5.4 6.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer F-protein PF00469.20 EDN09073.1 - 1.7 8.2 5.8 2.6 7.6 5.8 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef MecA PF05389.12 EDN09073.1 - 2.3 7.8 15.3 9.6 5.8 15.3 1.8 1 1 0 1 1 1 0 Negative regulator of genetic competence (MecA) Rrn6 PF10214.9 EDN09073.1 - 2.3 6.6 20.4 0.18 10.3 8.6 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor CPSF100_C PF13299.6 EDN09073.1 - 2.4 8.3 9.7 4.4 7.4 9.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 EDN09073.1 - 2.4 7.0 6.7 3.2 6.6 6.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 EDN09073.1 - 2.6 7.8 18.7 3.8 7.3 18.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop53 PF07767.11 EDN09073.1 - 3 7.1 20.4 4.3 6.6 20.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) V_ATPase_I PF01496.19 EDN09073.1 - 3.6 5.4 10.2 4.6 5.0 10.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2052 PF09747.9 EDN09073.1 - 3.7 7.6 18.2 5.4 7.1 18.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Hid1 PF12722.7 EDN09073.1 - 3.8 5.5 10.4 4.9 5.2 10.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NOA36 PF06524.12 EDN09073.1 - 3.8 6.8 7.2 5.1 6.3 7.2 1.1 1 0 0 1 1 1 0 NOA36 protein Peptidase_S64 PF08192.11 EDN09073.1 - 3.9 5.9 6.7 5.3 5.4 6.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 RNA_pol_Rpc4 PF05132.14 EDN09073.1 - 4.3 7.8 14.3 3.8 7.9 12.5 1.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 Plasmodium_Vir PF05795.11 EDN09073.1 - 4.4 6.6 4.7 5.8 6.2 4.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PTPRCAP PF15713.5 EDN09073.1 - 5.1 7.4 23.0 8.2 6.7 23.0 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Dicty_REP PF05086.12 EDN09073.1 - 5.7 4.8 6.2 7.5 4.4 6.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Rtf2 PF04641.12 EDN09073.1 - 7.2 5.9 14.8 11 5.3 14.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SLC12 PF03522.15 EDN09073.1 - 7.4 5.5 9.0 10 5.0 9.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 VIT1 PF01988.19 EDN09073.1 - 7.9 6.3 7.2 16 5.3 7.2 1.5 1 0 0 1 1 1 0 VIT family FAM60A PF15396.6 EDN09073.1 - 8.5 6.3 6.0 13 5.7 6.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Ydc2-catalyt PF09159.10 EDN09074.1 - 1.4e-98 330.1 0.0 1.7e-98 329.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 EDN09074.1 - 0.002 18.2 0.0 8.1 6.5 0.0 3.3 3 0 0 3 3 3 2 Poxvirus A22 protein Bac_rhamnosid PF05592.11 EDN09074.1 - 0.077 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain Trehalase PF01204.18 EDN09075.1 - 4.8e-71 240.1 0.0 5.9e-62 210.1 0.0 2.1 2 0 0 2 2 2 2 Trehalase Trehalase_Ca-bi PF07492.11 EDN09075.1 - 2.2e-16 59.3 0.7 3.5e-16 58.6 0.7 1.3 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Ribosomal_S21 PF01165.20 EDN09076.1 - 0.0089 15.7 0.1 2.1 8.1 0.1 2.3 2 0 0 2 2 2 2 Ribosomal protein S21 CorA PF01544.18 EDN09077.1 - 3e-11 43.2 1.7 8.3e-11 41.7 1.7 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Tcp11 PF05794.13 EDN09078.1 - 1.1e-96 324.7 2.8 1.3e-96 324.4 2.8 1.1 1 0 0 1 1 1 1 T-complex protein 11 DUF2564 PF10819.8 EDN09078.1 - 1.1 9.6 3.4 1.1 9.6 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) DUF3114 PF11311.8 EDN09078.1 - 2.7 7.5 7.2 0.98 8.9 3.2 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3114) SOG2 PF10428.9 EDN09080.1 - 8.3e-69 233.1 11.4 9.7e-69 232.9 0.4 2.9 2 1 0 2 2 2 1 RAM signalling pathway protein MRP-S25 PF13741.6 EDN09081.1 - 7.5e-81 271.1 2.4 8.7e-81 270.8 2.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EDN09081.1 - 0.049 13.9 0.1 0.39 11.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein S23 hGDE_N PF14699.6 EDN09081.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain from the human glycogen debranching enzyme PPR_2 PF13041.6 EDN09082.1 - 0.019 15.2 1.3 0.16 12.2 0.2 2.8 2 1 0 2 2 2 0 PPR repeat family DEAD PF00270.29 EDN09083.1 - 2.2e-16 60.2 0.0 1.1e-15 57.8 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN09083.1 - 1.5e-14 54.3 0.0 3.6e-11 43.4 0.0 3.3 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EDN09083.1 - 1.8e-08 34.9 1.3 1.8e-08 34.9 1.3 1.9 2 0 0 2 2 2 1 RecQ zinc-binding KH_1 PF00013.29 EDN09084.1 - 1.8e-08 34.1 0.0 5.4e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 KH domain SUIM_assoc PF16619.5 EDN09084.1 - 0.27 11.3 9.0 1.6 8.8 9.0 2.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 ALS_ss_C PF10369.9 EDN09085.1 - 1.7e-15 57.0 0.0 3.1e-14 52.9 0.0 2.3 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EDN09085.1 - 2.1e-12 46.6 0.2 3.7e-12 45.8 0.2 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EDN09085.1 - 5.2e-08 32.6 0.0 9.2e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EDN09085.1 - 0.058 13.4 0.1 17 5.5 0.0 2.5 2 0 0 2 2 2 0 ACT domain MEIOC PF15189.6 EDN09085.1 - 0.11 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC LEA_2 PF03168.13 EDN09087.1 - 5.8e-07 30.0 0.3 0.016 15.7 0.0 4.3 4 1 0 4 4 4 2 Late embryogenesis abundant protein DUF3712 PF12505.8 EDN09087.1 - 9.1e-07 29.2 0.2 5.9e-06 26.5 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) OTCace_N PF02729.21 EDN09088.1 - 6.5e-45 152.8 0.1 9.7e-45 152.2 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EDN09088.1 - 4.1e-41 140.7 0.0 5.9e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain DUF3984 PF13136.6 EDN09089.1 - 2.9e-68 230.7 17.2 3.4e-68 230.5 17.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) Na_trans_cytopl PF11933.8 EDN09090.1 - 0.05 13.4 0.4 0.1 12.4 0.4 1.5 1 0 0 1 1 1 0 Cytoplasmic domain of voltage-gated Na+ ion channel CRPA PF05745.11 EDN09090.1 - 0.053 13.5 0.3 0.099 12.7 0.0 1.6 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) EphA2_TM PF14575.6 EDN09090.1 - 0.1 13.5 0.0 0.19 12.6 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RcnB PF11776.8 EDN09091.1 - 0.038 14.0 0.3 2.9 8.0 0.0 2.7 2 0 0 2 2 2 0 Nickel/cobalt transporter regulator Cut8 PF08559.10 EDN09092.1 - 4.6e-82 275.3 0.0 5.9e-82 274.9 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein rRNA_proc-arch PF13234.6 EDN09093.1 - 4.6e-91 305.5 0.6 1.1e-90 304.2 0.0 2.0 3 0 0 3 3 3 1 rRNA-processing arch domain DSHCT PF08148.12 EDN09093.1 - 1.2e-55 187.6 2.3 1.7e-55 187.2 1.3 1.8 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EDN09093.1 - 9.1e-19 67.9 0.1 2.6e-18 66.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN09093.1 - 1.6e-06 28.4 0.0 7.1e-06 26.3 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN09093.1 - 0.00014 21.9 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN09093.1 - 0.12 12.7 0.0 0.4 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF5388 PF17363.2 EDN09093.1 - 0.26 11.5 0.9 0.76 10.0 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5388) COX7C PF02935.16 EDN09094.1 - 9.8e-15 54.6 1.9 1.3e-14 54.1 1.9 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc IKI3 PF04762.12 EDN09095.1 - 2.3e-144 482.7 0.0 2.7e-144 482.4 0.0 1.0 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EDN09095.1 - 0.00022 21.5 0.8 14 6.1 0.1 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 EDN09096.1 - 1.9e-74 251.3 2.1 7.4e-65 219.5 0.7 2.1 1 1 1 2 2 2 2 IKI3 family DHR-2 PF06920.13 EDN09096.1 - 0.023 13.4 1.9 0.05 12.2 1.7 1.6 2 0 0 2 2 2 0 Dock homology region 2 TPR_16 PF13432.6 EDN09096.1 - 0.66 10.7 4.5 0.68 10.6 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat MDD_C PF18376.1 EDN09097.1 - 2.8e-62 209.8 0.9 7.5e-61 205.1 0.9 2.2 1 1 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EDN09097.1 - 2.8e-09 37.1 0.9 6.5e-09 35.9 0.9 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain Cyto_heme_lyase PF01265.17 EDN09098.1 - 1e-25 91.0 8.6 1.2e-23 84.2 0.1 2.8 1 1 0 2 2 2 2 Cytochrome c/c1 heme lyase SPX PF03105.19 EDN09098.1 - 3.6 7.4 9.9 5 6.9 9.9 1.1 1 0 0 1 1 1 0 SPX domain Syntaxin_2 PF14523.6 EDN09099.1 - 1.2e-24 86.6 2.5 1.2e-24 86.6 2.5 2.6 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EDN09099.1 - 2.7e-13 49.7 1.7 2.7e-13 49.7 1.7 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EDN09099.1 - 4.8e-06 26.4 12.6 1.6e-05 24.7 12.6 1.8 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 EDN09099.1 - 0.0011 18.7 0.4 0.0044 16.8 0.3 2.1 2 0 0 2 2 2 1 Synaptobrevin DUF883 PF05957.13 EDN09099.1 - 0.06 14.0 9.7 0.33 11.6 0.1 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Prominin PF05478.11 EDN09099.1 - 0.13 10.2 4.8 0.21 9.5 4.7 1.4 1 1 0 1 1 1 0 Prominin DUF16 PF01519.16 EDN09099.1 - 0.49 10.9 8.8 1.4 9.5 1.8 2.9 1 1 1 3 3 3 0 Protein of unknown function DUF16 DUF1664 PF07889.12 EDN09099.1 - 0.67 10.0 3.7 19 5.3 0.9 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Ndc1_Nup PF09531.10 EDN09100.1 - 8.9e-103 345.1 0.0 1e-102 344.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Y_phosphatase2 PF03162.13 EDN09101.1 - 1.6e-46 157.9 0.0 2.3e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDN09101.1 - 1.5e-07 31.7 0.0 1.5e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EDN09101.1 - 5.5e-06 26.2 0.0 9.2e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDN09101.1 - 0.0016 18.1 0.0 0.0024 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EDN09101.1 - 0.0059 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EDN09101.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate TatD_DNase PF01026.21 EDN09102.1 - 7e-35 120.6 0.0 4.5e-29 101.6 0.0 2.0 2 0 0 2 2 2 2 TatD related DNase BRCA-2_OB1 PF09103.10 EDN09102.1 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 FMN_dh PF01070.18 EDN09103.1 - 5.3e-111 371.0 0.0 6.4e-111 370.7 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDN09103.1 - 8.3e-18 64.3 0.0 1.6e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDN09103.1 - 4.4e-06 26.1 0.0 6.8e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EDN09103.1 - 0.00017 21.1 0.2 0.00034 20.1 0.1 1.4 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDN09103.1 - 0.00019 20.5 0.0 0.00036 19.7 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EDN09103.1 - 0.0027 17.1 0.0 0.57 9.4 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 EDN09103.1 - 0.075 12.2 0.1 0.45 9.7 0.0 1.9 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Crr6 PF08847.11 EDN09103.1 - 0.14 11.8 0.0 0.55 9.9 0.0 1.8 2 0 0 2 2 2 0 Chlororespiratory reduction 6 SAP PF02037.27 EDN09104.1 - 5e-10 38.9 0.1 9.5e-10 38.0 0.1 1.4 1 0 0 1 1 1 1 SAP domain Asp PF00026.23 EDN09106.1 - 9.5e-48 163.2 0.0 1.2e-47 162.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDN09106.1 - 3.2e-05 24.2 0.0 7.1e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDN09106.1 - 0.083 13.5 0.0 28 5.4 0.0 2.5 2 0 0 2 2 2 0 Aspartyl protease DDE_1 PF03184.19 EDN09107.1 - 3.3e-31 108.3 0.1 6.4e-31 107.3 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN09107.1 - 7.8e-11 41.8 0.0 1.5e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN09107.1 - 6.3e-05 22.8 0.1 0.0035 17.1 0.0 2.6 3 0 0 3 3 3 1 DDE superfamily endonuclease zf-C2H2_jaz PF12171.8 EDN09110.1 - 0.00057 20.1 16.5 0.00072 19.8 4.1 4.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EDN09110.1 - 0.0031 17.9 0.7 0.0031 17.9 0.7 3.9 3 1 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDN09110.1 - 0.0033 17.8 2.0 0.0033 17.8 2.0 4.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.7 EDN09110.1 - 0.015 15.7 1.4 0.015 15.7 1.4 4.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDN09110.1 - 0.53 11.3 25.1 0.15 12.9 2.3 6.0 5 0 0 5 5 5 0 C2H2-type zinc finger zf-FCS PF06467.14 EDN09110.1 - 2.7 8.0 9.5 2.4 8.2 0.4 2.9 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-MYST PF17772.1 EDN09110.1 - 6 6.6 7.2 1 9.0 0.8 2.4 1 1 1 2 2 2 0 MYST family zinc finger domain Aa_trans PF01490.18 EDN09112.1 - 4.1e-41 141.1 13.0 8.4e-31 107.1 7.5 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Rad52_Rad22 PF04098.15 EDN09113.1 - 3.1e-34 118.1 2.6 5.7e-21 75.0 0.7 2.1 1 1 1 2 2 2 2 Rad52/22 family double-strand break repair protein Motile_Sperm PF00635.26 EDN09114.1 - 6.3e-26 90.4 0.3 1.1e-25 89.6 0.3 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 EDN09114.1 - 0.0025 18.0 0.1 0.0056 16.9 0.0 1.5 1 1 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin UBX PF00789.20 EDN09115.1 - 1.8e-08 34.4 0.4 5.5e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 EDN09115.1 - 4.6e-05 23.2 0.0 9.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Utp11 PF03998.13 EDN09115.1 - 0.018 15.0 20.4 0.024 14.6 20.4 1.2 1 0 0 1 1 1 0 Utp11 protein zf-C2H2_6 PF13912.6 EDN09115.1 - 0.079 13.0 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN09115.1 - 0.19 12.2 0.2 0.33 11.5 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EDN09115.1 - 0.22 11.9 0.3 0.22 11.9 0.3 1.9 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Rtf2 PF04641.12 EDN09115.1 - 0.39 10.0 19.2 0.64 9.3 19.2 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger SOBP PF15279.6 EDN09115.1 - 0.76 10.3 7.8 0.87 10.1 7.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein FapA PF03961.13 EDN09115.1 - 1.5 7.3 18.4 2.2 6.8 18.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Hid1 PF12722.7 EDN09115.1 - 1.8 6.6 11.2 2 6.5 11.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ACR_tran PF00873.19 EDN09115.1 - 3.6 5.1 6.3 4.5 4.8 6.3 1.0 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family CDC45 PF02724.14 EDN09115.1 - 6.3 5.0 17.3 7.6 4.7 17.3 1.1 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 EDN09115.1 - 9.1 4.0 10.3 10 3.9 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HSP70 PF00012.20 EDN09118.1 - 1.5e-06 26.8 0.0 1.8e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein FA_desaturase PF00487.24 EDN09119.1 - 2.8e-13 50.3 1.9 3.7e-13 49.9 1.9 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Asn_synthase PF00733.21 EDN09120.1 - 2.9e-60 204.8 0.6 5.8e-34 118.3 0.1 4.0 1 1 2 3 3 3 2 Asparagine synthase Peptidase_M24 PF00557.24 EDN09120.1 - 5.2e-36 124.3 0.3 8.2e-36 123.7 0.3 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 YL1 PF05764.13 EDN09120.1 - 0.029 14.5 6.4 0.046 13.8 6.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein RNA_pol_Rpc4 PF05132.14 EDN09120.1 - 1.5 9.2 5.6 2.6 8.4 5.6 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 EDN09120.1 - 5 5.1 5.3 7.4 4.5 5.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EDN09120.1 - 6 5.0 5.4 8.5 4.5 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein GATase_7 PF13537.6 EDN09121.1 - 4.6e-37 126.7 0.0 6.7e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDN09121.1 - 8.5e-28 97.2 0.0 1.4e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Asn_synthase PF00733.21 EDN09121.1 - 9.3e-16 58.4 0.1 1.3e-15 58.0 0.1 1.1 1 0 0 1 1 1 1 Asparagine synthase DUF3700 PF12481.8 EDN09121.1 - 6e-07 29.1 0.0 1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EDN09121.1 - 0.00066 18.9 0.0 0.001 18.3 0.0 1.1 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 EDN09121.1 - 0.058 12.9 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC UQ_con PF00179.26 EDN09122.1 - 6.1e-49 165.3 0.0 6.9e-49 165.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN09122.1 - 0.0056 16.4 0.0 0.0064 16.2 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDN09122.1 - 0.02 15.2 1.1 0.041 14.2 1.1 1.7 1 1 0 1 1 1 0 RWD domain YCII PF03795.14 EDN09123.1 - 2.3e-06 27.9 0.0 3.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 YCII-related domain T4_deiodinase PF00837.17 EDN09123.1 - 0.023 14.0 0.1 0.028 13.7 0.1 1.1 1 0 0 1 1 1 0 Iodothyronine deiodinase AMP-binding PF00501.28 EDN09124.1 - 5.3e-91 305.3 0.0 6.6e-91 305.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN09124.1 - 1.2e-07 32.6 0.0 5.1e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EDN09124.1 - 6.8e-05 21.9 0.0 0.00022 20.2 0.0 1.7 2 0 0 2 2 2 1 GH3 auxin-responsive promoter RTX_C PF08339.10 EDN09124.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 RTX C-terminal domain Anp1 PF03452.14 EDN09126.1 - 1.6e-32 113.0 0.0 2e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Anp1 UCR_14kD PF02271.16 EDN09127.1 - 7.6e-44 147.8 1.3 8.8e-44 147.6 1.3 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 EDN09128.1 - 1.4e-47 159.5 3.9 5.1e-20 71.2 0.1 3.6 2 2 1 3 3 3 3 Mitochondrial carrier protein p450 PF00067.22 EDN09129.1 - 1.1e-05 24.3 0.1 1.4e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 SAT PF16073.5 EDN09130.1 - 0.00034 20.4 0.1 0.00076 19.3 0.0 1.5 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Arm PF00514.23 EDN09131.1 - 0.012 15.6 0.1 26 5.1 0.0 4.8 6 1 1 7 7 7 0 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EDN09131.1 - 0.014 15.6 0.6 43 4.8 0.1 4.6 3 0 0 3 3 3 0 HEAT repeat DUF383 PF04063.14 EDN09131.1 - 0.039 13.6 0.1 0.16 11.6 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF383) HEAT_2 PF13646.6 EDN09131.1 - 0.15 12.4 1.1 4.1 7.9 0.1 3.7 4 1 0 4 4 4 0 HEAT repeats Clathrin PF00637.20 EDN09131.1 - 0.17 11.7 2.6 0.68 9.8 0.1 3.1 4 1 1 5 5 5 0 Region in Clathrin and VPS Pkinase PF00069.25 EDN09132.1 - 1.4e-62 211.5 0.0 8.3e-62 208.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09132.1 - 2.7e-42 144.9 0.0 3.7e-41 141.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN09132.1 - 0.0006 18.7 0.1 0.001 18.0 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDN09132.1 - 0.0096 15.3 0.0 0.11 11.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Ribonuc_red_lgC PF02867.15 EDN09138.1 - 1.8e-91 307.3 0.0 2.7e-91 306.7 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDN09138.1 - 7.9e-25 86.7 0.0 2.2e-24 85.3 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EDN09138.1 - 9.7e-17 61.3 0.0 1.8e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 ATP cone domain BCS1_N PF08740.11 EDN09141.1 - 7.3e-35 120.6 0.0 1.2e-34 119.9 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN09141.1 - 3.1e-20 73.0 0.0 1.5e-19 70.7 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN09141.1 - 7e-05 23.3 0.0 0.00018 22.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 EDN09141.1 - 0.028 13.8 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 EDN09141.1 - 0.034 14.3 0.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EDN09141.1 - 0.048 12.5 0.0 0.098 11.5 0.0 1.5 1 0 0 1 1 1 0 Papillomavirus helicase AAA_25 PF13481.6 EDN09141.1 - 0.06 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN09141.1 - 0.12 12.1 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN09141.1 - 0.14 12.1 0.0 0.41 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_S10 PF00450.22 EDN09141.1 - 0.17 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase Tn916-Xis PF09035.10 EDN09143.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Excisionase from transposon Tn916 Methyltransf_23 PF13489.6 EDN09144.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09144.1 - 0.0055 16.5 0.0 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN09144.1 - 0.069 13.9 0.0 0.13 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Glyco_tranf_2_3 PF13641.6 EDN09145.1 - 1.2e-22 80.9 0.0 1.7e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDN09145.1 - 0.00067 19.5 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EDN09145.1 - 0.0015 18.1 0.0 0.0035 16.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 APH PF01636.23 EDN09147.1 - 1.3e-09 38.3 0.0 8.4e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN09147.1 - 0.00058 19.5 0.0 0.00087 18.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EDN09147.1 - 0.0023 17.3 0.0 0.0033 16.8 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.14 EDN09147.1 - 0.013 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1679 PF07914.11 EDN09147.1 - 0.014 14.3 0.0 0.026 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) BTB PF00651.31 EDN09148.1 - 0.0003 21.0 0.0 0.00054 20.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C3HC4_3 PF13920.6 EDN09149.1 - 0.0043 16.9 6.6 0.0066 16.3 6.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HAUS-augmin3 PF14932.6 EDN09149.1 - 0.012 15.2 0.2 0.016 14.8 0.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DegS PF05384.11 EDN09149.1 - 0.017 14.6 0.5 0.024 14.1 0.5 1.1 1 0 0 1 1 1 0 Sensor protein DegS Sec2p PF06428.11 EDN09149.1 - 0.029 14.3 0.7 0.042 13.8 0.7 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p zf-C3HC4_2 PF13923.6 EDN09149.1 - 0.066 13.1 3.6 0.16 11.9 3.7 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ADIP PF11559.8 EDN09149.1 - 0.067 13.3 1.2 0.089 12.9 1.2 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding HAUS5 PF14817.6 EDN09149.1 - 0.1 11.3 0.3 0.13 10.9 0.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 BRE1 PF08647.11 EDN09149.1 - 0.12 12.5 0.5 0.17 12.0 0.5 1.2 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF5446 PF17522.2 EDN09149.1 - 0.13 12.4 0.6 0.2 11.8 0.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5446) CCDC158 PF15921.5 EDN09149.1 - 0.14 9.9 0.2 0.19 9.5 0.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Trimer_CC PF08954.11 EDN09149.1 - 0.19 11.3 4.0 0.61 9.7 3.9 1.9 1 1 0 1 1 1 0 Trimerisation motif zf-RING_2 PF13639.6 EDN09149.1 - 1.8 9.0 7.6 3.2 8.1 7.6 1.4 1 0 0 1 1 1 0 Ring finger domain C1ORF64 PF15547.6 EDN09151.1 - 0.013 15.9 0.2 0.022 15.2 0.2 1.3 1 0 0 1 1 1 0 Steroid receptor-associated and regulated protein DUF3915 PF13054.6 EDN09151.1 - 0.02 14.9 0.9 0.039 13.9 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) ELFV_dehydrog PF00208.21 EDN09152.1 - 2.7e-79 266.3 0.8 3.3e-79 266.1 0.8 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EDN09152.1 - 5.8e-19 68.3 0.1 2.6e-18 66.1 0.1 2.0 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 EDN09152.1 - 0.048 14.1 0.0 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Med5 PF08689.10 EDN09154.1 - 2.5e-106 356.8 0.0 7.1e-53 179.8 0.0 3.0 2 1 1 3 3 3 3 Mediator complex subunit Med5 zf-C2H2_10 PF16588.5 EDN09156.1 - 0.0081 15.9 3.0 0.015 15.0 3.0 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger Retrotran_gag_3 PF14244.6 EDN09156.1 - 0.033 14.0 0.1 0.074 12.9 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN09156.1 - 0.084 12.6 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Phage_min_cap2 PF06152.11 EDN09156.1 - 0.15 10.9 1.6 0.25 10.2 1.6 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 zn-ribbon_14 PF16503.5 EDN09157.1 - 4.3e-19 67.7 8.9 6.7e-19 67.1 3.8 2.9 3 0 0 3 3 3 1 Zinc-ribbon ATP_bind_3 PF01171.20 EDN09157.1 - 3.6e-08 33.4 0.0 5.7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 PP-loop family RecR PF02132.15 EDN09157.1 - 0.021 14.4 0.9 0.021 14.4 0.9 2.0 2 0 0 2 2 2 0 RecR protein Nucleo_P87 PF07267.11 EDN09158.1 - 0.00099 18.1 2.9 0.0012 17.8 2.9 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus capsid protein P87 RNase_H PF00075.24 EDN09159.1 - 5.8e-09 36.3 0.0 1.4e-08 35.1 0.0 1.6 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 EDN09159.1 - 3.7e-06 26.8 0.0 6.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase-like DUF1987 PF09345.10 EDN09159.1 - 0.18 11.5 0.0 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) NifU_N PF01592.16 EDN09160.1 - 7.4e-54 181.3 0.0 1e-53 180.9 0.0 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EDN09160.1 - 0.076 13.3 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 TSCPD domain MIT PF04212.18 EDN09161.1 - 1.3e-14 53.9 0.6 1.3e-14 53.9 0.6 1.8 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Helicase_C PF00271.31 EDN09162.1 - 6.1e-11 42.7 0.0 1.6e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1310 PF07006.11 EDN09162.1 - 0.19 11.7 0.0 0.4 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) DUF573 PF04504.14 EDN09166.1 - 6.4e-09 36.4 0.4 1e-08 35.7 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function, DUF573 Myb_DNA-binding PF00249.31 EDN09166.1 - 1.1e-05 25.5 0.4 2.5e-05 24.4 0.4 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN09166.1 - 0.0011 19.2 0.1 0.002 18.3 0.1 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDN09166.1 - 0.0012 19.1 2.8 0.02 15.2 2.8 2.2 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 EDN09166.1 - 0.11 12.7 2.8 0.23 11.7 0.8 2.3 2 1 0 2 2 2 0 SANT/Myb-like domain of DAMP1 OrsD PF12013.8 EDN09170.1 - 8.3e-06 26.2 0.2 8.3e-06 26.2 0.2 2.2 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D RVT_2 PF07727.14 EDN09171.1 - 1.5e-57 195.1 0.0 2.4e-57 194.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN09171.1 - 1.2e-11 44.8 0.0 8.5e-11 42.1 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN09171.1 - 1.4e-07 31.3 0.0 3.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDN09171.1 - 0.00013 21.6 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN09171.1 - 0.00015 21.3 0.0 0.00044 19.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4219) rve_3 PF13683.6 EDN09171.1 - 0.042 13.6 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain CALM_bind PF16025.5 EDN09171.1 - 0.054 14.0 0.4 0.15 12.5 0.4 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding ATP11 PF06644.11 EDN09173.1 - 3.6e-92 309.0 0.0 4.1e-92 308.8 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Hydrolase_4 PF12146.8 EDN09174.1 - 1.9e-17 63.3 0.0 9.7e-13 47.9 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDN09174.1 - 6.4e-11 42.4 0.0 6.3e-08 32.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 EDN09174.1 - 0.0001 22.1 0.0 0.0003 20.5 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EDN09174.1 - 0.0011 19.6 0.0 0.0015 19.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 EDN09174.1 - 0.0021 16.8 0.2 0.54 8.9 0.1 3.0 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 EDN09174.1 - 0.0037 17.2 0.0 0.11 12.4 0.0 2.3 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 EDN09174.1 - 0.0049 16.4 0.0 0.024 14.1 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF1057 PF06342.12 EDN09174.1 - 0.012 14.7 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DUF818 PF05677.12 EDN09174.1 - 0.016 14.2 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) PGAP1 PF07819.13 EDN09174.1 - 0.028 14.1 0.2 0.41 10.3 0.2 2.2 1 1 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 EDN09174.1 - 0.03 14.4 0.0 0.059 13.5 0.0 1.5 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_2 PF02230.16 EDN09174.1 - 0.041 13.7 0.1 1.5 8.6 0.0 2.4 1 1 1 3 3 3 0 Phospholipase/Carboxylesterase DLH PF01738.18 EDN09174.1 - 0.049 13.2 0.0 2 7.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family LIDHydrolase PF10230.9 EDN09174.1 - 0.081 12.5 0.0 0.17 11.4 0.0 1.3 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 EDN09174.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF561 PF04481.12 EDN09174.1 - 0.17 11.0 0.0 7.7 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF561) Peptidase_S28 PF05577.12 EDN09174.1 - 0.19 10.5 0.0 0.37 9.5 0.0 1.5 1 1 0 1 1 1 0 Serine carboxypeptidase S28 Proteasome PF00227.26 EDN09175.1 - 5.2e-34 117.4 1.5 2.8e-19 69.4 0.1 2.0 1 1 1 2 2 2 2 Proteasome subunit Cyclin PF08613.11 EDN09177.1 - 1.1e-40 139.6 1.6 1.4e-24 87.3 0.2 2.3 2 0 0 2 2 2 2 Cyclin RT_RNaseH PF17917.1 EDN09178.1 - 4.8e-39 132.9 0.5 4.8e-39 132.9 0.5 2.5 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN09178.1 - 2.6e-34 117.3 0.1 8e-34 115.7 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN09178.1 - 2.5e-28 99.1 0.0 6.2e-28 97.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN09178.1 - 3.3e-19 68.7 0.1 7.4e-19 67.6 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN09178.1 - 1.9e-14 53.8 0.0 5.8e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN09178.1 - 9.4e-13 47.9 0.2 2.7e-12 46.4 0.2 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN09178.1 - 5.6e-06 26.5 0.1 2.2e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Tudor-knot PF11717.8 EDN09178.1 - 0.005 16.7 0.2 0.042 13.7 0.0 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain TSNAXIP1_N PF15739.5 EDN09178.1 - 2 8.8 10.1 0.68 10.3 0.4 3.2 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus NDUFA12 PF05071.16 EDN09178.1 - 2.3 9.1 7.0 3.4 8.6 4.4 2.7 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 APH PF01636.23 EDN09179.1 - 1.2e-05 25.4 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RVT_1 PF00078.27 EDN09180.1 - 6.6e-32 110.8 0.0 1.2e-31 110.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN09180.1 - 5.5e-12 45.6 0.0 1.5e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN09180.1 - 1.5e-11 44.7 0.0 3.6e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN09180.1 - 0.065 13.7 0.4 0.25 11.8 0.4 2.0 1 0 0 1 1 1 0 ORF 12 gene product N-terminal Nexin_C PF08628.12 EDN09181.1 - 0.0066 17.0 0.2 0.0077 16.8 0.2 1.1 1 0 0 1 1 1 1 Sorting nexin C terminal RabGAP-TBC PF00566.18 EDN09183.1 - 1.2e-28 100.2 0.0 2e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EDN09183.1 - 9.2e-08 30.8 1.0 9.2e-08 30.8 1.0 2.0 2 0 0 2 2 2 1 SBE2, cell-wall formation Telomerase_RBD PF12009.8 EDN09184.1 - 2.6e-47 160.3 0.7 6.5e-47 159.0 0.1 2.1 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EDN09184.1 - 3.2e-10 39.9 0.0 7e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGEF PF00621.20 EDN09185.1 - 2.2e-37 129.1 0.1 6.2e-37 127.6 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain Peptidase_C48 PF02902.19 EDN09187.1 - 6.5e-15 55.6 0.1 2.3e-14 53.8 0.1 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF4951 PF16309.5 EDN09187.1 - 0.018 15.1 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) DDE_1 PF03184.19 EDN09191.1 - 1.4e-30 106.3 0.0 1.3e-29 103.1 0.0 2.4 3 0 0 3 3 3 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN09191.1 - 0.0022 17.8 0.0 0.006 16.3 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease RB_B PF01857.20 EDN09191.1 - 0.072 13.1 0.7 0.12 12.4 0.7 1.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain HisG PF01634.18 EDN09193.1 - 7.9e-53 178.7 0.0 1.2e-52 178.2 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EDN09193.1 - 1.9e-29 101.6 0.2 3.8e-29 100.7 0.2 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 EDN09193.1 - 0.027 14.4 0.0 0.062 13.2 0.0 1.5 1 1 0 1 1 1 0 NMT1/THI5 like Ribosomal_S28e PF01200.18 EDN09194.1 - 2.4e-32 110.7 0.7 2.7e-32 110.6 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e MutS_V PF00488.21 EDN09195.1 - 2.9e-74 249.2 0.2 6.6e-74 248.0 0.1 1.7 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EDN09195.1 - 6.8e-38 130.8 0.9 1.6e-37 129.6 0.9 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EDN09195.1 - 1.4e-29 102.6 0.0 3.2e-29 101.4 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EDN09195.1 - 2e-07 31.4 0.0 8.2e-07 29.4 0.0 2.1 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EDN09195.1 - 0.0015 18.8 0.1 0.0062 16.9 0.1 2.1 1 0 0 1 1 1 1 MutS family domain IV DUF4911 PF16256.5 EDN09195.1 - 0.068 13.2 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) zf-SCNM1 PF15803.5 EDN09196.1 - 0.4 10.4 1.8 0.79 9.4 1.8 1.5 1 0 0 1 1 1 0 Zinc-finger of sodium channel modifier 1 Prenyltrans PF00432.21 EDN09197.1 - 1e-55 185.1 7.8 5.2e-11 42.1 0.0 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EDN09197.1 - 0.0022 17.2 0.0 0.087 11.9 0.0 3.0 2 1 1 3 3 3 1 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EDN09197.1 - 0.022 13.9 0.0 0.69 9.0 0.0 2.4 1 1 1 2 2 2 0 Squalene-hopene cyclase C-terminal domain RhoGAP PF00620.27 EDN09198.1 - 2.3e-26 92.4 0.0 4.2e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain RRS1 PF04939.12 EDN09199.1 - 2.4e-50 170.6 0.0 3.2e-50 170.1 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DAP3 PF10236.9 EDN09200.1 - 1.9e-107 359.0 0.0 2.4e-107 358.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_10 PF12846.7 EDN09200.1 - 0.083 11.8 0.1 1 8.2 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain AAA PF00004.29 EDN09201.1 - 7.7e-54 181.7 0.0 3.2e-43 147.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EDN09201.1 - 1.5e-29 102.2 0.3 2.9e-29 101.3 0.3 1.5 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EDN09201.1 - 2.5e-14 52.8 0.0 6.9e-09 35.4 0.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EDN09201.1 - 1.8e-07 31.7 7.9 0.0035 17.8 0.1 4.2 3 2 1 5 5 4 2 AAA ATPase domain NACHT PF05729.12 EDN09201.1 - 6.8e-07 29.3 0.9 0.00028 20.8 0.0 3.3 3 0 0 3 3 3 1 NACHT domain TsaE PF02367.17 EDN09201.1 - 3.3e-06 27.1 0.0 0.0041 17.1 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EDN09201.1 - 9.5e-06 25.4 0.0 0.015 15.1 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDN09201.1 - 1.2e-05 25.6 1.7 0.14 12.4 0.1 3.8 2 2 1 3 3 3 2 AAA domain AAA_2 PF07724.14 EDN09201.1 - 5e-05 23.5 0.0 0.14 12.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EDN09201.1 - 6.4e-05 23.5 0.0 0.13 12.8 0.0 3.0 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EDN09201.1 - 0.00019 21.2 0.1 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_14 PF13173.6 EDN09201.1 - 0.00048 20.2 0.0 0.58 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EDN09201.1 - 0.0016 17.7 0.0 0.36 10.1 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin KAP_NTPase PF07693.14 EDN09201.1 - 0.0017 17.7 0.3 0.028 13.6 0.0 2.4 1 1 1 2 2 2 1 KAP family P-loop domain AAA_7 PF12775.7 EDN09201.1 - 0.0019 17.7 0.0 0.057 12.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 EDN09201.1 - 0.0029 17.9 0.0 0.84 9.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EDN09201.1 - 0.0038 17.2 0.1 2.7 8.0 0.1 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EDN09201.1 - 0.0059 17.0 0.0 6.3 7.2 0.0 2.8 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 EDN09201.1 - 0.0062 17.1 0.0 1.3 9.5 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 EDN09201.1 - 0.0074 16.7 0.0 2.9 8.3 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDN09201.1 - 0.015 15.5 0.0 0.22 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 EDN09201.1 - 0.016 14.4 0.0 1.7 7.7 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain Viral_helicase1 PF01443.18 EDN09201.1 - 0.019 14.7 0.0 0.54 10.0 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EDN09201.1 - 0.021 14.2 0.1 0.89 8.9 0.1 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EDN09201.1 - 0.033 14.1 0.0 0.34 10.8 0.0 2.2 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 EDN09201.1 - 0.037 13.8 0.1 0.56 10.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cytidylate_kin2 PF13189.6 EDN09201.1 - 0.04 14.1 0.1 7.2 6.7 0.0 3.1 3 0 0 3 3 3 0 Cytidylate kinase-like family ATPase PF06745.13 EDN09201.1 - 0.046 13.0 0.0 6.4 6.0 0.0 2.3 2 0 0 2 2 2 0 KaiC DUF815 PF05673.13 EDN09201.1 - 0.068 12.3 0.0 0.82 8.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DnaB_C PF03796.15 EDN09201.1 - 0.084 12.2 1.5 5.4 6.3 0.0 3.9 4 1 1 5 5 5 0 DnaB-like helicase C terminal domain AAA_25 PF13481.6 EDN09201.1 - 0.092 12.3 3.5 8.5 5.9 0.2 3.7 2 2 2 4 4 4 0 AAA domain Rad17 PF03215.15 EDN09201.1 - 0.13 12.1 0.0 10 6.0 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain cobW PF02492.19 EDN09201.1 - 0.57 9.8 3.7 2.4 7.7 0.0 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MCM PF00493.23 EDN09202.1 - 5.1e-103 343.0 0.0 8.1e-103 342.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDN09202.1 - 1.4e-32 112.2 0.2 2.6e-32 111.3 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDN09202.1 - 4e-19 68.8 1.2 1.2e-18 67.2 1.2 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDN09202.1 - 3.8e-17 62.8 0.2 1.2e-16 61.2 0.2 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDN09202.1 - 5.6e-07 29.1 0.0 5.6e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDN09202.1 - 1.2e-05 25.3 0.0 3.8e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 EDN09202.1 - 0.0036 17.1 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA lid domain Mg_chelatase_C PF13335.6 EDN09202.1 - 0.0039 17.8 0.8 0.013 16.1 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 EDN09202.1 - 0.08 12.8 0.0 0.28 11.1 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) EGF_CA PF07645.15 EDN09203.1 - 7.3e-05 22.9 6.2 7.3e-05 22.9 6.2 1.9 2 0 0 2 2 2 1 Calcium-binding EGF domain EGF_3 PF12947.7 EDN09203.1 - 0.00059 20.0 3.5 0.00059 20.0 3.5 1.8 2 0 0 2 2 2 1 EGF domain FXa_inhibition PF14670.6 EDN09203.1 - 0.0017 18.6 4.3 0.0017 18.6 4.3 2.3 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 EDN09203.1 - 0.019 14.9 1.4 0.019 14.9 1.4 2.1 2 1 0 2 2 2 0 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 EDN09203.1 - 7.1 7.0 12.7 0.079 13.3 2.5 2.6 2 1 0 2 2 2 0 Pvs28 EGF domain AMP-binding PF00501.28 EDN09204.1 - 1.9e-88 296.9 0.0 1.3e-47 162.4 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EDN09204.1 - 2.4e-14 54.0 0.3 5.6e-14 52.9 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Bul1_C PF04426.12 EDN09205.1 - 0.00011 21.8 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 Bul1 C terminus Nop25 PF09805.9 EDN09207.1 - 6.6e-39 133.5 7.3 6.6e-39 133.5 7.3 2.9 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) Tropomyosin_1 PF12718.7 EDN09208.1 - 1.1e-54 184.5 34.8 1.3e-54 184.3 34.8 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EDN09208.1 - 1.8e-09 37.4 33.4 0.00011 21.6 14.9 2.6 1 1 1 2 2 2 2 Tropomyosin KLRAQ PF10205.9 EDN09208.1 - 0.00019 21.6 24.0 0.00049 20.3 9.4 3.0 1 1 2 3 3 3 1 Predicted coiled-coil domain-containing protein Cast PF10174.9 EDN09208.1 - 0.00025 19.4 25.3 0.00055 18.3 14.1 2.0 1 1 1 2 2 2 2 RIM-binding protein of the cytomatrix active zone FlaC_arch PF05377.11 EDN09208.1 - 0.00054 20.3 18.1 0.23 11.9 0.1 4.2 2 1 2 4 4 4 3 Flagella accessory protein C (FlaC) ATG16 PF08614.11 EDN09208.1 - 0.00062 20.1 34.7 0.026 14.8 13.2 2.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EDN09208.1 - 0.0014 17.6 32.6 0.06 12.2 12.9 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein Uso1_p115_C PF04871.13 EDN09208.1 - 0.0029 18.0 35.9 0.15 12.5 15.1 2.0 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region ADIP PF11559.8 EDN09208.1 - 0.0034 17.5 32.3 0.073 13.2 10.7 3.0 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding DUF4200 PF13863.6 EDN09208.1 - 0.0087 16.5 32.7 0.046 14.1 14.9 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4200) DUF3450 PF11932.8 EDN09208.1 - 0.01 15.2 28.3 0.44 9.8 14.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 EDN09208.1 - 0.014 15.6 33.5 0.037 14.3 25.3 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMF_TATA_bd PF12325.8 EDN09208.1 - 0.022 15.0 26.9 0.71 10.1 15.9 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 EDN09208.1 - 0.024 14.0 33.1 0.063 12.6 15.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding MAD PF05557.13 EDN09208.1 - 0.024 13.0 28.2 0.055 11.8 15.1 1.8 1 1 1 2 2 2 0 Mitotic checkpoint protein BST2 PF16716.5 EDN09208.1 - 0.029 14.9 28.6 0.19 12.3 11.1 3.5 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 Taxilin PF09728.9 EDN09208.1 - 0.031 13.4 29.8 0.16 11.1 29.8 2.0 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF724 PF05266.14 EDN09208.1 - 0.033 14.0 24.3 0.16 11.8 8.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Laminin_II PF06009.12 EDN09208.1 - 0.034 14.2 19.1 0.029 14.4 6.4 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 EDN09208.1 - 0.041 13.9 13.9 0.99 9.5 6.3 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 EDN09208.1 - 0.054 13.6 32.5 0.15 12.2 11.7 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DHR10 PF18595.1 EDN09208.1 - 0.068 13.2 36.1 0.087 12.9 13.8 2.6 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain EzrA PF06160.12 EDN09208.1 - 0.071 11.3 24.3 0.033 12.4 6.3 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA APG6_N PF17675.1 EDN09208.1 - 0.073 13.6 40.3 4.7 7.7 24.7 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Phage_GP20 PF06810.11 EDN09208.1 - 0.096 12.5 27.0 0.41 10.4 3.5 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 CENP-F_leu_zip PF10473.9 EDN09208.1 - 0.1 12.6 33.0 0.076 13.0 4.8 3.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPD39 PF18858.1 EDN09208.1 - 0.11 12.5 21.9 20 5.2 21.9 2.0 1 1 0 1 1 1 0 Large polyvalent protein associated domain 39 BRE1 PF08647.11 EDN09208.1 - 0.14 12.3 32.9 0.52 10.4 9.5 2.1 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4686 PF15742.5 EDN09208.1 - 0.15 11.1 31.1 0.18 10.9 31.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) HAP1_N PF04849.13 EDN09208.1 - 0.16 11.2 29.6 1.7 7.8 7.9 2.9 1 1 0 2 2 2 0 HAP1 N-terminal conserved region Sipho_Gp157 PF05565.11 EDN09208.1 - 0.17 11.9 24.3 0.73 9.8 8.6 2.1 2 0 0 2 2 2 0 Siphovirus Gp157 BLOC1_2 PF10046.9 EDN09208.1 - 0.17 12.2 22.6 0.2 12.0 0.7 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ERM PF00769.19 EDN09208.1 - 0.19 11.5 37.7 0.2 11.5 17.1 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family WXG100 PF06013.12 EDN09208.1 - 0.2 11.9 16.0 2 8.7 0.2 3.4 2 1 1 3 3 3 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 EDN09208.1 - 0.27 11.7 11.5 3.7 8.1 0.1 3.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Shugoshin_N PF07558.11 EDN09208.1 - 0.29 11.0 0.2 0.29 11.0 0.2 3.6 3 1 0 3 3 3 0 Shugoshin N-terminal coiled-coil region SOGA PF11365.8 EDN09208.1 - 0.31 12.2 24.2 2.6 9.2 10.3 3.1 2 1 1 3 3 3 0 Protein SOGA ZapB PF06005.12 EDN09208.1 - 0.31 11.5 37.8 5.5 7.5 17.5 3.9 1 1 2 3 3 3 0 Cell division protein ZapB Lebercilin PF15619.6 EDN09208.1 - 0.34 10.6 35.6 5.1 6.7 18.2 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 EDN09208.1 - 0.34 11.0 31.7 0.06 13.4 6.3 4.4 2 1 2 5 5 4 0 bZIP transcription factor CALCOCO1 PF07888.11 EDN09208.1 - 0.41 9.5 31.6 1.2 7.9 10.5 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_DNA_bd PF12329.8 EDN09208.1 - 0.41 10.7 36.1 0.19 11.8 12.9 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Fez1 PF06818.15 EDN09208.1 - 0.53 10.7 28.4 1.7 9.0 28.5 1.6 1 1 0 1 1 1 0 Fez1 YjcZ PF13990.6 EDN09208.1 - 0.55 9.6 13.8 0.17 11.2 8.6 1.9 1 1 1 2 2 2 0 YjcZ-like protein LegC3_N PF18654.1 EDN09208.1 - 0.66 9.2 23.1 1 8.5 12.2 2.4 1 1 1 2 2 2 0 LegC3 N-terminal coiled-coil domain DUF812 PF05667.11 EDN09208.1 - 0.71 8.7 28.6 1.5 7.6 28.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Prefoldin_2 PF01920.20 EDN09208.1 - 0.76 9.8 32.3 0.18 11.8 1.5 4.1 2 1 2 4 4 4 0 Prefoldin subunit Leu_zip PF15294.6 EDN09208.1 - 0.86 9.1 24.3 1.4 8.4 24.3 1.3 1 0 0 1 1 1 0 Leucine zipper Rootletin PF15035.6 EDN09208.1 - 0.92 9.5 32.4 0.09 12.8 10.1 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion PI3K_P85_iSH2 PF16454.5 EDN09208.1 - 0.93 9.1 26.7 19 4.8 26.6 2.4 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CASP_C PF08172.12 EDN09208.1 - 0.94 8.8 24.0 0.1 11.9 1.8 2.3 1 1 1 2 2 2 0 CASP C terminal TPR_MLP1_2 PF07926.12 EDN09208.1 - 0.98 9.5 38.1 1.6 8.8 9.0 3.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fmp27_WPPW PF10359.9 EDN09208.1 - 0.98 8.2 25.6 0.043 12.7 10.2 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain CLZ PF16526.5 EDN09208.1 - 1.1 9.7 26.7 1.2 9.5 3.2 3.8 1 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Atg14 PF10186.9 EDN09208.1 - 1.4 8.0 26.0 0.28 10.2 10.5 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 KASH_CCD PF14662.6 EDN09208.1 - 1.4 8.7 32.6 0.82 9.5 21.1 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF2203 PF09969.9 EDN09208.1 - 1.5 9.6 18.8 2.6 8.8 5.4 2.2 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) HOOK PF05622.12 EDN09208.1 - 1.5 6.9 30.5 2 6.5 30.5 1.2 1 0 0 1 1 1 0 HOOK protein YabA PF06156.13 EDN09208.1 - 1.5 9.5 24.2 2.3 8.9 10.5 3.1 1 1 2 3 3 3 0 Initiation control protein YabA bZIP_2 PF07716.15 EDN09208.1 - 1.7 8.8 38.1 0.37 10.9 2.5 5.5 2 2 4 6 6 6 0 Basic region leucine zipper Lectin_N PF03954.14 EDN09208.1 - 1.7 8.4 17.8 1.3 8.8 5.3 2.8 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain DUF745 PF05335.13 EDN09208.1 - 1.7 8.3 23.0 0.37 10.5 3.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) FapA PF03961.13 EDN09208.1 - 1.8 7.1 25.9 0.35 9.4 9.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A TMPIT PF07851.13 EDN09208.1 - 2 7.6 21.9 1.4 8.1 3.4 2.0 1 1 1 2 2 2 0 TMPIT-like protein KELK PF15796.5 EDN09208.1 - 2.1 8.9 32.8 15 6.2 15.7 3.9 2 2 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase T3SSipB PF16535.5 EDN09208.1 - 2.7 8.5 22.0 11 6.5 3.7 2.7 1 1 2 3 3 2 0 Type III cell invasion protein SipB JAKMIP_CC3 PF16034.5 EDN09208.1 - 2.7 7.9 26.7 1 9.2 6.4 3.1 1 1 2 3 3 3 0 JAKMIP CC3 domain XhlA PF10779.9 EDN09208.1 - 2.7 8.2 27.8 6.7 7.0 5.5 4.4 1 1 3 4 4 4 0 Haemolysin XhlA Fib_alpha PF08702.10 EDN09208.1 - 2.8 8.1 18.0 4.4 7.5 5.7 2.8 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family FUSC PF04632.12 EDN09208.1 - 2.8 6.4 10.8 3.3 6.1 10.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GIT_CC PF16559.5 EDN09208.1 - 2.8 7.9 18.2 1.5 8.7 1.4 3.8 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor AAA_13 PF13166.6 EDN09208.1 - 3 6.4 24.1 1.5 7.3 9.9 2.1 1 1 1 2 2 2 0 AAA domain JIP_LZII PF16471.5 EDN09208.1 - 3 8.1 25.9 1.4 9.1 8.0 3.7 2 1 0 3 3 3 0 JNK-interacting protein leucine zipper II Striatin PF08232.12 EDN09208.1 - 3.7 8.1 23.9 10 6.7 0.8 2.1 1 1 1 2 2 2 0 Striatin family DUF3584 PF12128.8 EDN09208.1 - 3.8 4.9 30.2 7.1 4.0 30.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DivIC PF04977.15 EDN09208.1 - 4 7.3 34.3 0.43 10.4 7.8 4.4 2 1 2 4 4 4 0 Septum formation initiator V_ATPase_I PF01496.19 EDN09208.1 - 4 5.2 22.6 0.17 9.7 7.1 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family CENP-H PF05837.12 EDN09208.1 - 4.2 7.8 28.0 5.7 7.4 10.3 3.0 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF4201 PF13870.6 EDN09208.1 - 4.2 7.1 28.9 5.7 6.6 10.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF948 PF06103.11 EDN09208.1 - 4.3 7.6 13.0 11 6.4 2.2 2.9 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 EDN09208.1 - 5.5 6.3 25.7 1.3 8.3 6.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4482 PF14818.6 EDN09208.1 - 6.3 7.7 23.4 1.5 9.7 3.3 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4482) SlyX PF04102.12 EDN09208.1 - 6.9 7.4 25.3 3.9 8.2 6.3 3.8 1 1 3 4 4 4 0 SlyX Phage_GPO PF05929.11 EDN09208.1 - 7.2 6.2 21.8 6.6 6.3 8.0 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Syntaxin-6_N PF09177.11 EDN09208.1 - 7.5 7.2 22.1 6.1 7.5 4.4 3.1 1 1 3 4 4 4 0 Syntaxin 6, N-terminal Cep57_CLD_2 PF14197.6 EDN09208.1 - 7.7 6.7 32.6 3.1 7.9 4.6 3.6 2 2 1 3 3 3 0 Centrosome localisation domain of PPC89 HAUS-augmin3 PF14932.6 EDN09208.1 - 8 5.9 30.8 2.1 7.9 13.1 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Med9 PF07544.13 EDN09208.1 - 8.4 6.6 24.1 3.2 7.9 0.9 3.3 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 MPS2 PF17060.5 EDN09208.1 - 8.6 5.5 18.2 25 4.0 18.2 1.7 1 1 0 1 1 1 0 Monopolar spindle protein 2 GCN5L1 PF06320.13 EDN09208.1 - 9.5 6.4 21.1 4.5 7.5 9.1 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) Nup88 PF10168.9 EDN09208.1 - 9.6 3.9 22.2 12 3.5 22.2 1.1 1 0 0 1 1 1 0 Nuclear pore component RE_AccI PF09545.10 EDN09209.1 - 0.049 12.6 0.0 0.074 12.0 0.0 1.1 1 0 0 1 1 1 0 AccI restriction endonuclease CMAS PF02353.20 EDN09210.1 - 7.6e-62 209.1 0.1 9.4e-62 208.8 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EDN09210.1 - 3e-09 36.9 0.0 5.4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN09210.1 - 4.7e-09 36.8 0.0 1.1e-08 35.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN09210.1 - 4.9e-09 36.8 0.0 1.1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09210.1 - 0.0006 20.5 0.0 0.0014 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09210.1 - 0.0051 16.6 0.0 0.0087 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EDN09210.1 - 0.0082 15.7 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 EDN09210.1 - 0.0091 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EDN09210.1 - 0.044 13.5 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ATP-synt_S1 PF05827.12 EDN09211.1 - 6.9e-06 26.0 0.2 1.2e-05 25.2 0.2 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Mucin PF01456.17 EDN09212.1 - 0.00024 21.1 1.9 0.0005 20.1 1.9 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein GRP PF07172.11 EDN09212.1 - 3.9 8.2 0.0 3.9 8.2 0.0 2.9 2 1 0 2 2 2 0 Glycine rich protein family EXS PF03124.14 EDN09213.1 - 6.5e-94 314.9 9.0 7.9e-94 314.7 9.0 1.0 1 0 0 1 1 1 1 EXS family Pex2_Pex12 PF04757.14 EDN09214.1 - 1e-34 120.1 2.2 2e-18 66.9 0.7 2.1 1 1 1 2 2 2 2 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EDN09214.1 - 6.1e-11 42.0 9.1 1e-10 41.3 9.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN09214.1 - 1.5e-10 40.7 7.9 2.4e-10 40.1 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN09214.1 - 1.7e-10 41.1 10.0 2.6e-10 40.5 10.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN09214.1 - 4.4e-10 39.3 5.8 6.6e-10 38.7 5.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN09214.1 - 5.3e-08 32.8 8.0 1.1e-07 31.7 8.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDN09214.1 - 2.2e-07 30.7 6.6 3.4e-07 30.1 6.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDN09214.1 - 4e-07 29.8 5.5 6.4e-07 29.1 5.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDN09214.1 - 1.9e-06 27.9 8.4 3.3e-06 27.1 8.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDN09214.1 - 2.8e-06 27.5 7.5 5.6e-06 26.6 7.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EDN09214.1 - 0.00016 21.8 5.1 0.00027 21.0 5.1 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EDN09214.1 - 0.0031 17.4 2.7 0.0068 16.3 2.7 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Transposase_23 PF03017.14 EDN09214.1 - 0.046 13.7 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 TNP1/EN/SPM transposase zf-ANAPC11 PF12861.7 EDN09214.1 - 0.051 13.6 2.3 0.051 13.6 2.3 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 EDN09214.1 - 0.66 9.8 4.8 1.2 9.0 4.8 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EDN09214.1 - 0.94 9.3 9.6 2.1 8.2 9.4 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EDN09214.1 - 1 9.0 5.5 2 8.1 5.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DNA_pol_A_exo1 PF01612.20 EDN09215.1 - 1.2e-13 51.1 0.1 2.6e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 3'-5' exonuclease LSM PF01423.22 EDN09216.1 - 1.2e-18 66.6 0.3 3.1e-16 58.8 0.1 2.0 2 0 0 2 2 2 2 LSM domain DUF1280 PF06918.14 EDN09216.1 - 0.089 12.4 0.1 0.2 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1280) AA_permease PF00324.21 EDN09218.1 - 9.3e-146 486.2 39.0 1.1e-145 485.9 39.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDN09218.1 - 1.5e-36 126.1 38.4 2e-36 125.7 38.4 1.0 1 0 0 1 1 1 1 Amino acid permease AP_endonuc_2 PF01261.24 EDN09219.1 - 8.7e-11 41.7 0.0 1.5e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AMP-binding PF00501.28 EDN09220.1 - 2.3e-39 135.2 0.0 1.4e-35 122.7 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme RhoGAP PF00620.27 EDN09221.1 - 2e-16 60.2 0.6 5.7e-16 58.7 0.6 1.7 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 EDN09221.1 - 1.2e-12 47.7 0.0 2.5e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EDN09221.1 - 7.4e-09 35.8 0.0 3e-08 33.8 0.0 2.1 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Phage_TAC_8 PF10666.9 EDN09221.1 - 0.0081 16.4 3.9 0.018 15.3 0.3 2.5 2 0 0 2 2 2 1 Phage tail assembly chaperone protein Gp14 ()A118 SLX9 PF15341.6 EDN09221.1 - 0.039 14.3 0.3 0.51 10.7 0.0 2.5 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 Methyltransf_23 PF13489.6 EDN09222.1 - 2.5e-17 63.2 0.0 3.4e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN09222.1 - 3.9e-10 40.3 0.0 1.3e-09 38.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09222.1 - 2.4e-08 33.9 0.0 0.001 18.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDN09222.1 - 1.2e-07 32.3 0.0 4.3e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09222.1 - 1.4e-07 32.1 0.0 2.3e-06 28.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDN09222.1 - 0.00093 18.8 0.0 0.011 15.3 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase small domain PrmA PF06325.13 EDN09222.1 - 0.0074 15.7 0.0 0.015 14.7 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EDN09222.1 - 0.01 15.3 0.1 0.034 13.6 0.0 1.8 3 0 0 3 3 3 0 Putative methyltransferase FtsJ PF01728.19 EDN09222.1 - 0.015 15.4 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EDN09222.1 - 0.05 12.9 0.0 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EDN09222.1 - 0.17 11.6 0.0 0.39 10.5 0.0 1.5 2 0 0 2 2 2 0 Lysine methyltransferase GidB PF02527.15 EDN09222.1 - 0.22 10.8 0.0 0.52 9.6 0.0 1.6 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G p450 PF00067.22 EDN09223.1 - 4.2e-45 154.4 0.0 5.8e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AAA PF00004.29 EDN09224.1 - 8.9e-14 52.1 0.0 1.6e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN09224.1 - 4.3e-12 46.5 0.0 1.1e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN09224.1 - 3.1e-10 40.7 0.4 1.1e-09 38.9 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain Cdc6_C PF09079.11 EDN09224.1 - 5.8e-06 26.2 0.0 1.7e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain TniB PF05621.11 EDN09224.1 - 2.3e-05 23.9 0.0 4.9e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Bacterial TniB protein NACHT PF05729.12 EDN09224.1 - 0.0011 19.0 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain TIP49 PF06068.13 EDN09224.1 - 0.0013 18.0 0.0 0.0021 17.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_lid_10 PF17872.1 EDN09224.1 - 0.002 18.2 0.0 0.0048 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_7 PF12775.7 EDN09224.1 - 0.0031 17.1 0.0 0.0066 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 EDN09224.1 - 0.0036 17.6 0.0 0.012 16.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDN09224.1 - 0.0083 16.5 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 EDN09224.1 - 0.016 14.4 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 EDN09224.1 - 0.02 15.0 0.0 0.068 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EDN09224.1 - 0.031 13.5 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PIF1 PF05970.14 EDN09224.1 - 0.037 13.2 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_29 PF13555.6 EDN09224.1 - 0.037 13.8 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EDN09224.1 - 0.042 13.6 0.1 0.082 12.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain Thioredoxin_7 PF13899.6 EDN09225.1 - 4.2e-15 55.7 0.0 8.6e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EDN09225.1 - 6e-14 51.6 0.0 1.1e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EDN09225.1 - 7.4e-06 26.1 0.0 1.9e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain Pkinase PF00069.25 EDN09226.1 - 2.9e-42 144.9 2.3 9.5e-29 100.6 0.0 2.6 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09226.1 - 3.3e-29 102.0 0.0 3e-20 72.6 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase DUF4692 PF15763.5 EDN09226.1 - 0.72 10.3 13.5 2.6 8.5 1.8 3.6 3 0 0 3 3 3 0 Regulator of human erythroid cell expansion (RHEX) p450 PF00067.22 EDN09227.1 - 1.1e-13 50.8 0.0 1.4e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L39 PF00832.20 EDN09227.1 - 0.047 13.3 0.3 0.11 12.1 0.3 1.7 1 0 0 1 1 1 0 Ribosomal L39 protein p450 PF00067.22 EDN09228.1 - 0.061 12.1 0.0 0.067 11.9 0.0 1.0 1 0 0 1 1 1 0 Cytochrome P450 ADH_N PF08240.12 EDN09230.1 - 4.4e-24 84.5 1.4 9.5e-24 83.4 1.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN09230.1 - 1.1e-20 73.9 0.1 1.8e-20 73.2 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PALP PF00291.25 EDN09230.1 - 0.0048 16.4 1.8 0.014 14.8 0.2 2.1 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N_2 PF13602.6 EDN09230.1 - 0.0057 17.7 0.0 0.012 16.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EDN09230.1 - 0.0093 15.8 0.0 0.04 13.8 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase MIP-T3_C PF17749.1 EDN09233.1 - 0.021 14.8 0.5 0.062 13.3 0.5 1.8 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region DUF2852 PF11014.8 EDN09233.1 - 2.8 8.1 5.2 2.3 8.4 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) zf-H2C2_2 PF13465.6 EDN09234.1 - 1e-08 35.2 9.1 2e-06 28.0 1.9 4.1 4 0 0 4 4 3 2 Zinc-finger double domain DUF1192 PF06698.11 EDN09234.1 - 0.0041 17.2 0.2 0.013 15.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) zf-C2H2_6 PF13912.6 EDN09234.1 - 0.0058 16.6 0.0 0.0058 16.6 0.0 4.4 4 0 0 4 4 3 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EDN09234.1 - 0.0065 16.6 1.8 0.0065 16.6 1.8 2.5 1 1 1 2 2 2 2 Zinc ribbon domain zf-C2HC_2 PF13913.6 EDN09234.1 - 0.016 15.1 0.9 0.043 13.7 0.9 1.7 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 EDN09234.1 - 0.079 13.4 0.1 0.06 13.8 4.8 4.6 5 0 0 5 5 4 0 Zinc finger, C2H2 type ATPase-cat_bd PF12156.8 EDN09234.1 - 0.23 12.2 4.0 0.67 10.7 4.0 1.8 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase zf-C2H2_4 PF13894.6 EDN09234.1 - 0.33 11.9 0.1 0.33 11.9 0.1 4.8 4 0 0 4 4 3 0 C2H2-type zinc finger DZR PF12773.7 EDN09234.1 - 0.34 11.0 7.6 2.3 8.3 7.5 2.2 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.19 EDN09234.1 - 0.78 9.8 3.9 2.7 8.0 3.9 1.8 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 EDN09234.1 - 2.2 9.1 5.3 2.3 9.0 0.8 2.3 1 1 0 2 2 2 0 zinc-ribbon family Zn_ribbon_SprT PF17283.2 EDN09234.1 - 5.5 7.0 14.6 3.5 7.6 4.4 2.7 1 1 2 3 3 3 0 SprT-like zinc ribbon domain DUF3074 PF11274.8 EDN09235.1 - 2.5e-46 158.0 0.0 5.7e-46 156.8 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) Methyltransf_23 PF13489.6 EDN09236.1 - 1.3e-20 73.9 0.0 1.8e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN09236.1 - 4.6e-11 43.3 0.0 2.4e-10 41.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN09236.1 - 1.1e-10 42.0 0.0 2.6e-10 40.8 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09236.1 - 6.1e-08 32.6 0.0 0.0051 16.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09236.1 - 2.2e-05 25.1 0.0 0.00031 21.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN09236.1 - 2.9e-05 23.5 0.0 0.0048 16.3 0.0 2.9 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EDN09236.1 - 0.0046 16.4 0.0 0.026 14.0 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 EDN09236.1 - 0.0074 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 EDN09236.1 - 0.026 13.8 0.0 0.053 12.8 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 EDN09236.1 - 0.029 13.9 0.0 0.075 12.6 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 EDN09236.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Stk19 PF10494.9 EDN09238.1 - 8.7e-87 290.9 0.0 1e-86 290.7 0.0 1.0 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Glyco_transf_20 PF00982.21 EDN09239.1 - 1.7e-149 498.6 1.2 2.3e-149 498.1 0.4 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDN09239.1 - 1.6e-40 138.7 0.0 2.9e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EDN09239.1 - 0.01 15.5 0.8 0.022 14.5 0.8 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain CARD_2 PF16739.5 EDN09239.1 - 0.07 13.1 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 Caspase recruitment domain 4HBT PF03061.22 EDN09240.1 - 5.8e-10 39.4 0.1 9.6e-10 38.7 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily eIF3m_C_helix PF18005.1 EDN09242.1 - 6e-11 41.8 2.4 1.2e-10 40.8 2.4 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 EDN09242.1 - 6.2e-10 39.5 0.0 1.5e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 PCI domain ADK PF00406.22 EDN09243.1 - 2.9e-41 141.1 0.3 4.6e-21 75.5 0.2 2.1 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EDN09243.1 - 6.9e-34 117.2 3.2 2.2e-18 67.0 0.1 2.3 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.6 EDN09243.1 - 1.6e-10 41.6 0.0 3.6e-10 40.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDN09243.1 - 7.6e-07 29.4 0.5 6.4e-06 26.4 0.5 2.3 1 1 0 1 1 1 1 AAA domain DUF2052 PF09747.9 EDN09243.1 - 0.00012 22.3 1.6 0.00015 22.0 1.6 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) MAGE_N PF12440.8 EDN09243.1 - 0.003 18.2 7.1 0.003 18.2 7.1 2.2 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal FAM176 PF14851.6 EDN09243.1 - 0.0051 16.5 0.4 0.011 15.4 0.4 1.5 1 0 0 1 1 1 1 FAM176 family Spt20 PF12090.8 EDN09243.1 - 0.0063 16.2 2.7 0.0092 15.6 2.7 1.3 1 0 0 1 1 1 1 Spt20 family Hydin_ADK PF17213.3 EDN09243.1 - 0.018 15.4 6.1 2.2 8.5 0.0 2.3 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain SUIM_assoc PF16619.5 EDN09243.1 - 0.038 14.0 11.4 0.038 14.0 11.4 2.2 3 0 0 3 3 2 0 Unstructured region C-term to UIM in Ataxin3 PAXNEB PF05625.11 EDN09243.1 - 0.041 13.0 0.8 0.065 12.4 0.8 1.2 1 0 0 1 1 1 0 PAXNEB protein RuvC_III PF18541.1 EDN09243.1 - 0.042 13.8 1.5 0.071 13.0 1.5 1.3 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 Ploopntkinase3 PF18751.1 EDN09243.1 - 0.042 13.8 0.4 0.55 10.1 0.0 2.1 1 1 1 2 2 2 0 P-loop Nucleotide Kinase3 DUF4834 PF16118.5 EDN09243.1 - 0.053 14.5 1.5 0.14 13.1 1.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 EDN09243.1 - 0.062 13.4 1.8 0.099 12.7 1.8 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Thymidylate_kin PF02223.17 EDN09243.1 - 0.066 12.9 8.5 0.55 9.9 0.0 3.0 2 1 1 3 3 3 0 Thymidylate kinase Pex26 PF07163.12 EDN09243.1 - 0.068 12.5 0.6 0.09 12.1 0.6 1.1 1 0 0 1 1 1 0 Pex26 protein Presenilin PF01080.17 EDN09243.1 - 0.27 10.0 0.3 0.29 9.8 0.3 1.1 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 EDN09243.1 - 0.54 9.1 7.9 0.81 8.6 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) WTX PF09422.10 EDN09243.1 - 0.59 9.1 5.7 0.074 12.1 0.8 1.8 2 0 0 2 2 2 0 WTX protein SPAN PF02510.14 EDN09243.1 - 0.94 8.6 3.5 1.4 8.0 3.5 1.2 1 0 0 1 1 1 0 Surface presentation of antigens protein MscS_TM PF12794.7 EDN09243.1 - 1 8.1 7.2 1.5 7.6 7.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Dfp1_Him1_M PF08630.10 EDN09243.1 - 1.1 9.5 4.5 4.5 7.5 4.5 1.9 1 1 0 1 1 1 0 Dfp1/Him1, central region Androgen_recep PF02166.16 EDN09243.1 - 2.7 6.7 5.5 3.9 6.2 5.5 1.2 1 0 0 1 1 1 0 Androgen receptor CcmD PF04995.14 EDN09243.1 - 3.4 7.8 5.4 8.6 6.5 5.4 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) COX1 PF00115.20 EDN09244.1 - 0.00045 19.2 2.6 0.00061 18.8 2.6 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF1129 PF06570.11 EDN09244.1 - 0.0054 16.3 0.5 0.02 14.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1129) MARVEL PF01284.23 EDN09244.1 - 0.0065 16.5 6.7 0.0087 16.1 6.0 1.6 1 1 0 1 1 1 1 Membrane-associating domain DUF1218 PF06749.12 EDN09244.1 - 0.01 16.3 2.4 0.011 16.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Tetraspanin PF00335.20 EDN09244.1 - 0.015 15.0 4.8 0.017 14.9 3.8 1.5 1 1 0 1 1 1 0 Tetraspanin family DUF2781 PF10914.8 EDN09244.1 - 0.4 11.1 3.0 1.1 9.6 2.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) DUF2700 PF10912.8 EDN09244.1 - 0.45 10.5 6.0 9.1 6.3 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2700) Strabismus PF06638.11 EDN09244.1 - 0.46 9.1 2.6 1.1 7.9 2.1 1.7 1 1 1 2 2 2 0 Strabismus protein Cnd2 PF05786.14 EDN09245.1 - 2.9e-302 1005.1 0.3 1.9e-159 532.8 4.1 2.0 1 1 1 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 EDN09245.1 - 0.001 19.3 0.5 0.0053 17.0 0.0 2.4 3 0 0 3 3 3 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF4611 PF15387.6 EDN09245.1 - 0.39 11.0 7.0 0.16 12.2 3.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Glyco_tranf_2_3 PF13641.6 EDN09246.1 - 1.5e-30 106.8 0.0 1.8e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDN09246.1 - 4.5e-09 36.0 0.0 1.3e-08 34.5 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDN09246.1 - 4.1e-06 26.7 0.0 8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF3206 PF11472.8 EDN09246.1 - 0.18 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) Cys_rich_CPCC PF14206.6 EDN09247.1 - 0.15 11.9 1.4 0.39 10.6 1.4 1.7 1 0 0 1 1 1 0 Cysteine-rich CPCC zf-C2H2_4 PF13894.6 EDN09247.1 - 0.21 12.5 11.0 0.79 10.7 1.2 4.4 3 0 0 3 3 3 0 C2H2-type zinc finger Na_Ca_ex PF01699.24 EDN09248.1 - 7e-51 172.2 51.5 8.4e-28 97.2 19.0 3.4 3 0 0 3 3 3 3 Sodium/calcium exchanger protein Vpu PF00558.19 EDN09248.1 - 0.11 12.3 0.0 0.43 10.4 0.0 2.0 1 0 0 1 1 1 0 Vpu protein IncE PF17627.2 EDN09248.1 - 2.2 8.3 6.7 1.2 9.1 0.6 2.7 2 0 0 2 2 2 0 Inclusion membrane protein E EF-hand_4 PF12763.7 EDN09249.1 - 1.9e-25 88.8 0.0 2.1e-13 50.1 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 EDN09249.1 - 2.5e-10 39.9 1.4 5.1e-10 38.8 1.4 1.6 1 0 0 1 1 1 1 WH2 motif DUF1720 PF08226.11 EDN09249.1 - 2.2e-07 31.2 56.1 1.6e-05 25.2 31.8 9.0 7 2 3 10 10 10 2 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 EDN09249.1 - 0.0025 17.2 0.0 0.42 10.3 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EDN09249.1 - 0.0033 17.9 4.9 0.028 14.9 0.0 3.3 4 0 0 4 4 4 1 EF-hand domain pair RNA_pol_L_2 PF13656.6 EDN09250.1 - 2.1e-24 85.1 0.0 3.4e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDN09250.1 - 5e-10 38.7 0.0 1.2e-09 37.5 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain CorA PF01544.18 EDN09250.1 - 0.043 13.1 0.0 0.048 13.0 0.0 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein FAM176 PF14851.6 EDN09251.1 - 2 8.1 10.3 12 5.6 6.9 3.0 2 0 0 2 2 2 0 FAM176 family PBP1_TM PF14812.6 EDN09251.1 - 3.7 8.0 21.0 1.3 9.4 2.2 3.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LRR_6 PF13516.6 EDN09253.1 - 0.3 11.2 13.6 4.9 7.5 0.2 6.9 9 0 0 9 9 9 0 Leucine Rich repeat SNF2_N PF00176.23 EDN09254.1 - 3.4e-39 134.6 1.0 8.6e-38 129.9 1.0 2.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN09254.1 - 3.5e-17 62.8 0.0 2.1e-16 60.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EDN09254.1 - 1.2e-06 28.3 6.4 2.5e-06 27.3 6.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN09254.1 - 0.0013 19.1 8.4 0.0032 17.7 8.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN09254.1 - 0.0018 18.1 6.8 0.0018 18.1 6.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN09254.1 - 0.0055 16.5 6.0 0.011 15.6 6.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ERCC3_RAD25_C PF16203.5 EDN09254.1 - 0.0062 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-RING_UBOX PF13445.6 EDN09254.1 - 0.015 15.3 7.3 0.036 14.1 7.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger AAA_34 PF13872.6 EDN09254.1 - 0.029 13.3 0.0 0.06 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 zf-RING_10 PF16685.5 EDN09254.1 - 0.035 14.2 2.5 0.095 12.9 2.5 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 EDN09254.1 - 0.061 13.5 6.7 0.15 12.2 6.7 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_Tnp_IS91 PF14319.6 EDN09254.1 - 0.066 13.3 1.1 0.19 11.8 1.1 1.7 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-rbx1 PF12678.7 EDN09254.1 - 0.55 10.6 4.9 1.4 9.3 4.9 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EDN09254.1 - 0.97 9.3 7.1 2.5 8.0 7.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDN09254.1 - 1 9.4 11.3 0.17 11.9 7.4 1.8 2 0 0 2 2 2 0 zinc-RING finger domain Sec2p PF06428.11 EDN09256.1 - 2.5e-11 43.4 11.5 5.4e-11 42.3 11.5 1.5 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p ATG16 PF08614.11 EDN09256.1 - 0.00024 21.4 14.4 0.00024 21.4 14.4 2.1 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) FAM76 PF16046.5 EDN09256.1 - 0.0012 18.3 2.0 0.0015 17.9 2.0 1.2 1 0 0 1 1 1 1 FAM76 protein Jnk-SapK_ap_N PF09744.9 EDN09256.1 - 0.051 13.8 15.8 0.41 10.9 12.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF2072 PF09845.9 EDN09256.1 - 0.058 13.6 4.7 1.6 9.0 0.1 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF2746 PF10874.8 EDN09256.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) TFIIA PF03153.13 EDN09256.1 - 0.099 12.6 11.4 0.13 12.2 11.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_S27 PF01599.19 EDN09256.1 - 0.13 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S27a DUF2362 PF10154.9 EDN09256.1 - 0.19 10.7 4.4 0.045 12.7 1.3 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2362) Cdh1_DBD_1 PF18196.1 EDN09256.1 - 0.33 11.3 5.0 3.8 7.8 3.2 2.4 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 Cluap1 PF10234.9 EDN09256.1 - 0.36 10.2 13.9 0.46 9.8 13.9 1.3 1 1 0 1 1 1 0 Clusterin-associated protein-1 BRI3BP PF14965.6 EDN09256.1 - 0.44 10.0 2.0 12 5.3 1.2 2.2 2 0 0 2 2 2 0 Negative regulator of p53/TP53 DUF1682 PF07946.14 EDN09256.1 - 0.67 9.1 9.5 0.92 8.6 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SOG2 PF10428.9 EDN09256.1 - 0.77 8.9 16.5 1.1 8.4 16.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 EDN09256.1 - 0.78 9.6 14.8 0.97 9.3 14.8 1.1 1 0 0 1 1 1 0 SPX domain Lebercilin PF15619.6 EDN09256.1 - 1.3 8.6 20.8 0.53 9.9 15.4 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Latarcin PF10279.9 EDN09256.1 - 1.7 9.1 6.3 3.3 8.2 6.3 1.5 1 0 0 1 1 1 0 Latarcin precursor DUF4407 PF14362.6 EDN09256.1 - 1.9 7.7 7.1 1.3 8.3 4.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ECM11 PF15463.6 EDN09256.1 - 2.2 8.8 12.8 0.16 12.6 5.5 2.2 2 0 0 2 2 2 0 Extracellular mutant protein 11 Exonuc_VII_L PF02601.15 EDN09256.1 - 2.8 7.4 15.9 0.048 13.2 5.8 2.4 3 0 0 3 3 3 0 Exonuclease VII, large subunit GCN5L1 PF06320.13 EDN09256.1 - 3.7 7.7 10.2 0.95 9.6 6.6 1.8 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) OmpH PF03938.14 EDN09256.1 - 6.2 7.2 14.3 0.18 12.2 7.2 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Ndc1_Nup PF09531.10 EDN09256.1 - 6.9 5.2 15.5 8.9 4.9 15.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HR1 PF02185.16 EDN09256.1 - 7.3 6.8 19.6 0.23 11.6 6.0 3.3 2 1 1 3 3 3 0 Hr1 repeat GET2 PF08690.10 EDN09256.1 - 9.9 5.7 14.1 1.4 8.5 4.8 2.1 1 1 1 2 2 2 0 GET complex subunit GET2 Heme_oxygenase PF01126.20 EDN09257.1 - 9.1e-06 25.6 0.0 0.00036 20.4 0.0 2.4 1 1 0 1 1 1 1 Heme oxygenase Ribosomal_L32e PF01655.18 EDN09258.1 - 2.7e-48 162.8 1.4 3e-48 162.7 0.4 1.5 1 1 1 2 2 2 1 Ribosomal protein L32 Sugar_tr PF00083.24 EDN09259.1 - 4.2e-84 283.0 18.2 5.1e-84 282.7 18.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN09259.1 - 6.6e-25 87.8 28.4 4.3e-17 62.1 3.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AIF_C PF14721.6 EDN09260.1 - 7.7 6.9 13.2 0.35 11.2 0.9 2.3 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DDE_1 PF03184.19 EDN09261.1 - 1.7e-17 63.6 0.0 3.7e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN09261.1 - 7.5e-05 22.5 0.0 0.00027 20.7 0.0 1.9 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN09261.1 - 0.00064 19.7 0.0 0.0025 17.8 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN09261.1 - 0.0075 16.0 0.5 0.013 15.2 0.5 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN09261.1 - 0.019 14.5 0.0 0.053 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) PseudoU_synth_2 PF00849.22 EDN09262.1 - 2.4e-25 89.5 0.0 4.2e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EDN09262.1 - 0.0025 17.5 0.1 0.0054 16.4 0.1 1.6 1 0 0 1 1 1 1 S4 domain DUF2757 PF10955.8 EDN09262.1 - 0.21 11.9 0.3 1.6 9.0 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) 4HBT PF03061.22 EDN09263.1 - 1.6e-07 31.6 0.0 3e-07 30.7 0.0 1.5 1 1 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 EDN09263.1 - 8.6e-05 21.9 0.1 0.00014 21.3 0.1 1.2 1 0 0 1 1 1 1 Acyl-ACP thioesterase 4HBT_2 PF13279.6 EDN09263.1 - 0.00028 21.4 0.0 0.00036 21.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily DnaJ_C PF01556.18 EDN09264.1 - 2.6e-32 111.9 0.0 3.3e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain tRNA-synt_1c PF00749.21 EDN09265.1 - 3.2e-45 154.4 0.0 4.6e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain FabA PF07977.13 EDN09265.1 - 0.091 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 FabA-like domain MAP65_ASE1 PF03999.12 EDN09266.1 - 1.2e-76 258.7 3.7 1.9e-76 258.1 3.7 1.3 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Prominin PF05478.11 EDN09266.1 - 0.24 9.3 1.0 12 3.7 0.0 2.2 2 0 0 2 2 2 0 Prominin Occludin_ELL PF07303.13 EDN09266.1 - 4.6 8.0 8.2 1.8 9.3 0.1 3.8 3 2 0 3 3 3 0 Occludin homology domain JAB PF01398.21 EDN09267.1 - 7.6e-30 103.3 0.2 1.8e-29 102.1 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EDN09267.1 - 4.4e-22 78.8 0.0 8.5e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EDN09267.1 - 0.00028 20.6 0.0 0.00052 19.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF2721 PF11026.8 EDN09268.1 - 0.03 14.2 1.8 0.03 14.2 1.8 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) Wzy_C PF04932.15 EDN09268.1 - 0.56 9.8 5.8 1.2 8.7 0.0 2.4 2 0 0 2 2 2 0 O-Antigen ligase FAD_binding_4 PF01565.23 EDN09269.1 - 1.4e-17 63.7 0.1 1.4e-17 63.7 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Fungal_trans PF04082.18 EDN09270.1 - 2.4e-19 69.4 2.2 4e-19 68.7 2.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TRM PF02005.16 EDN09270.1 - 0.082 12.1 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase zf-C2H2_4 PF13894.6 EDN09270.1 - 0.11 13.4 4.1 0.52 11.3 4.1 2.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN09270.1 - 0.16 12.5 8.9 0.037 14.5 4.6 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDN09270.1 - 0.34 11.2 4.3 1 9.7 2.0 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding RT_RNaseH PF17917.1 EDN09271.1 - 1.1e-45 154.2 0.4 5.7e-45 151.9 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN09271.1 - 4.2e-33 114.7 0.1 7.1e-33 114.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN09271.1 - 2e-27 95.1 0.0 3.9e-14 52.5 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN09271.1 - 1.1e-20 73.5 0.4 2.3e-20 72.4 0.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN09271.1 - 1.2e-15 57.2 0.5 3.4e-15 55.7 0.5 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN09271.1 - 1.9e-10 40.9 0.0 4.2e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN09271.1 - 0.00011 22.4 0.1 0.00026 21.1 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 EDN09271.1 - 0.065 13.9 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 EDN09271.1 - 0.14 12.8 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RasGEF PF00617.19 EDN09273.1 - 3.3e-58 196.8 1.0 6.6e-58 195.8 0.4 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EDN09273.1 - 1.4e-28 99.2 0.5 3.3e-28 98.0 0.5 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EDN09273.1 - 1.4e-14 53.4 0.1 2.9e-14 52.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDN09273.1 - 2.2e-12 46.6 0.1 6.4e-12 45.1 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDN09273.1 - 1.8e-11 43.5 0.0 6e-11 41.9 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain WW PF00397.26 EDN09273.1 - 0.0023 17.9 0.0 0.0048 17.0 0.0 1.5 1 0 0 1 1 1 1 WW domain PFL-like PF02901.15 EDN09274.1 - 0.0026 16.5 1.4 0.0026 16.5 1.4 1.5 1 1 1 2 2 2 1 Pyruvate formate lyase-like DUF3746 PF12562.8 EDN09274.1 - 0.092 12.7 0.6 0.2 11.6 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) HalX PF08663.10 EDN09274.1 - 0.31 11.4 5.7 4.2 7.8 0.4 2.3 1 1 1 2 2 2 0 HalX domain Latarcin PF10279.9 EDN09274.1 - 0.88 10.0 4.1 2.2 8.7 4.1 1.9 1 1 0 1 1 1 0 Latarcin precursor UPRTase PF14681.6 EDN09276.1 - 4.3e-75 251.7 0.0 5.5e-75 251.4 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EDN09276.1 - 2.7e-05 23.7 0.1 7.8e-05 22.2 0.1 1.7 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 EDN09276.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl synthetase-associated domain CRCB PF02537.15 EDN09277.1 - 1.1e-41 141.0 0.0 1.9e-22 79.4 7.4 2.5 2 1 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Prion_bPrPp PF11587.8 EDN09277.1 - 3.1 7.7 4.3 3.7 7.5 0.6 2.5 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal RNA_pol_Rpc4 PF05132.14 EDN09279.1 - 7e-09 36.3 0.2 7e-09 36.3 0.2 3.9 4 1 0 4 4 4 1 RNA polymerase III RPC4 Zn_clus PF00172.18 EDN09281.1 - 0.00096 19.2 12.8 0.0023 18.0 12.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 EDN09281.1 - 0.012 15.0 0.1 0.035 13.6 0.1 1.8 1 0 0 1 1 1 0 Histone chaperone domain CHZ Cyclin_N PF00134.23 EDN09282.1 - 1.5e-44 150.8 0.6 2.6e-44 150.0 0.6 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDN09282.1 - 5.4e-36 123.3 0.0 1.2e-35 122.2 0.0 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain HA2 PF04408.23 EDN09283.1 - 3.7e-18 65.8 0.4 1.2e-17 64.1 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDN09283.1 - 3.8e-16 59.2 0.0 9.3e-16 58.0 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDN09283.1 - 1.2e-11 44.9 0.0 2.9e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 EDN09283.1 - 1.2e-10 41.7 0.2 2.9e-10 40.4 0.2 1.6 1 0 0 1 1 1 1 RWD domain DEAD PF00270.29 EDN09283.1 - 3e-09 36.9 0.2 5.5e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EDN09283.1 - 0.00011 21.3 0.0 0.00026 20.1 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein CoA_trans PF01144.23 EDN09283.1 - 0.00056 19.4 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 Coenzyme A transferase ResIII PF04851.15 EDN09283.1 - 0.0006 19.9 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UBA PF00627.31 EDN09283.1 - 0.00087 19.2 0.0 0.0087 16.0 0.0 2.4 2 0 0 2 2 2 1 UBA/TS-N domain DND1_DSRM PF14709.7 EDN09283.1 - 0.0061 16.8 0.8 0.021 15.1 0.8 2.0 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_22 PF13401.6 EDN09283.1 - 0.0087 16.3 3.8 0.14 12.4 3.8 2.7 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 EDN09283.1 - 0.012 15.0 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 EDN09283.1 - 0.023 14.4 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EDN09283.1 - 0.026 14.3 0.0 0.083 12.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain dsRBD2 PF17842.1 EDN09283.1 - 0.026 14.7 0.1 0.068 13.4 0.1 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 PhoH PF02562.16 EDN09283.1 - 0.041 13.3 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_23 PF13476.6 EDN09283.1 - 0.054 14.0 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDN09283.1 - 0.067 13.5 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain Nudix_N PF12535.8 EDN09283.1 - 0.1 12.2 1.1 0.44 10.2 0.0 2.3 2 0 0 2 2 2 0 Hydrolase of X-linked nucleoside diphosphate N terminal IHABP4_N PF16174.5 EDN09283.1 - 9.5 6.8 12.0 0.27 11.8 3.6 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal zf-C2HE PF16278.5 EDN09284.1 - 4.2e-19 68.8 0.5 9.6e-19 67.6 0.1 1.8 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 EDN09284.1 - 2.3e-16 60.3 2.9 3.4e-15 56.5 2.9 2.1 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EDN09284.1 - 3.5e-16 59.7 0.2 8.7e-16 58.5 0.2 1.7 1 1 0 1 1 1 1 HIT domain SIP1 PF04938.12 EDN09284.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) TRAP_alpha PF03896.16 EDN09285.1 - 3e-10 39.8 0.2 1.2e-09 37.9 0.2 1.8 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit zf-CCCH_4 PF18044.1 EDN09286.1 - 9.5 6.2 15.2 9.3 6.2 2.7 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger POT1PC PF16686.5 EDN09287.1 - 8e-50 168.7 0.3 2.1e-49 167.4 0.3 1.7 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EDN09287.1 - 1.5e-29 102.7 0.0 4.5e-29 101.1 0.0 1.9 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 Arm PF00514.23 EDN09288.1 - 1e-93 304.9 12.7 9e-14 51.0 0.2 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EDN09288.1 - 1.2e-27 96.1 0.8 3e-27 94.9 0.8 1.7 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 EDN09288.1 - 9.6e-24 82.7 2.6 2.2e-23 81.6 2.6 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 EDN09288.1 - 4.4e-21 75.0 5.4 1.8e-08 34.7 0.1 6.2 4 1 2 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 EDN09288.1 - 9.1e-20 70.9 0.1 1.5e-08 34.9 0.0 5.1 1 1 4 6 6 6 4 HEAT repeats HEAT PF02985.22 EDN09288.1 - 7.2e-19 66.3 0.1 1.8e-05 24.6 0.0 6.6 7 0 0 7 7 7 4 HEAT repeat Arm_2 PF04826.13 EDN09288.1 - 7.9e-09 35.3 0.0 0.00069 19.2 0.0 3.8 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 EDN09288.1 - 8.9e-05 22.6 0.0 2.4 8.3 0.0 4.3 3 2 2 5 5 5 2 V-ATPase subunit H Adaptin_N PF01602.20 EDN09288.1 - 0.00033 19.4 0.0 0.095 11.2 0.0 2.6 1 1 1 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 EDN09288.1 - 0.0021 18.1 0.0 1.8 8.6 0.0 2.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EDN09288.1 - 0.011 16.3 5.7 1.1 10.2 0.1 4.9 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Mo25 PF08569.11 EDN09288.1 - 0.012 15.0 0.0 0.025 14.0 0.0 1.5 1 0 0 1 1 1 0 Mo25-like Atx10homo_assoc PF09759.9 EDN09288.1 - 0.014 15.4 0.1 17 5.5 0.0 3.5 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain NopRA1 PF16201.5 EDN09288.1 - 0.023 14.3 0.0 32 4.0 0.0 3.7 2 1 2 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 EDN09288.1 - 0.14 12.4 6.6 2.8 8.3 0.1 4.8 4 2 2 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 NUSAP PF16006.5 EDN09288.1 - 4.7 6.9 6.0 6.7 6.4 6.0 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Amidase PF01425.21 EDN09289.1 - 3.3e-104 349.4 0.0 4.9e-104 348.8 0.0 1.2 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.16 EDN09291.1 - 1.7e-33 116.0 24.8 1.7e-33 116.0 24.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDN09291.1 - 4.4e-07 29.5 0.7 4.4e-07 29.5 0.7 2.6 2 1 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB Pkinase PF00069.25 EDN09292.1 - 0.011 15.1 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Yae1_N PF09811.9 EDN09293.1 - 6.9e-13 48.1 0.3 1.3e-12 47.2 0.3 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal RNase_E_G PF10150.9 EDN09294.1 - 0.13 11.6 2.8 0.24 10.8 2.8 1.3 1 0 0 1 1 1 0 Ribonuclease E/G family SCO1-SenC PF02630.14 EDN09295.1 - 5.1e-47 159.2 0.0 7.1e-47 158.7 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EDN09295.1 - 0.0051 16.7 0.0 0.01 15.8 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EDN09295.1 - 0.014 15.7 0.0 0.033 14.5 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 EDN09295.1 - 0.024 14.3 0.1 0.18 11.5 0.0 2.3 2 1 0 2 2 2 0 Redoxin Aldo_ket_red PF00248.21 EDN09296.1 - 2.2e-58 197.8 0.0 2.8e-58 197.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family G-patch PF01585.23 EDN09297.1 - 6e-10 38.9 3.0 1.4e-09 37.7 3.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDN09297.1 - 7.1e-06 26.0 1.0 7.1e-06 26.0 1.0 2.0 2 0 0 2 2 2 1 G-patch domain RRM_1 PF00076.22 EDN09297.1 - 2e-05 24.3 0.0 6.2e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RED_N PF07808.13 EDN09297.1 - 0.00024 20.8 2.2 0.00043 19.9 2.2 1.4 1 0 0 1 1 1 1 RED-like protein N-terminal region Rad50_zn_hook PF04423.14 EDN09297.1 - 0.55 10.1 4.2 0.28 11.1 0.4 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF1682 PF07946.14 EDN09297.1 - 2.8 7.1 8.4 5.2 6.2 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RTA1 PF04479.13 EDN09300.1 - 1.6e-70 236.9 5.2 1.6e-70 236.9 5.2 1.6 2 0 0 2 2 2 1 RTA1 like protein DUF2567 PF10821.8 EDN09300.1 - 0.011 15.8 3.6 0.51 10.4 0.8 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2567) DctQ PF04290.12 EDN09300.1 - 0.081 12.8 5.2 1.8 8.5 0.5 2.8 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DHHC PF01529.20 EDN09300.1 - 4.9 7.3 7.2 19 5.3 1.1 2.8 3 1 0 3 3 3 0 DHHC palmitoyltransferase DUF3433 PF11915.8 EDN09301.1 - 3.1e-31 107.7 22.7 3.8e-25 88.2 3.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) AAA PF00004.29 EDN09303.1 - 0.0037 17.7 0.1 0.012 16.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN09303.1 - 0.004 17.4 0.1 0.8 10.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.7 EDN09303.1 - 0.004 16.1 0.0 0.73 8.7 0.0 2.1 2 0 0 2 2 2 2 AAA-like domain ThiP_synth PF10120.9 EDN09303.1 - 0.0066 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Thiamine-phosphate synthase FtsK_SpoIIIE PF01580.18 EDN09303.1 - 0.029 13.7 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 EDN09303.1 - 0.066 13.6 0.0 7.8 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EDN09303.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF87 PF01935.17 EDN09303.1 - 0.16 12.0 0.0 4.6 7.3 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain SUR7 PF06687.12 EDN09304.1 - 3.3e-26 92.3 9.0 4.3e-26 91.9 9.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family RTA1 PF04479.13 EDN09305.1 - 2.9e-42 144.6 3.3 4e-42 144.2 3.3 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF308 PF03729.13 EDN09305.1 - 0.028 14.7 1.4 0.028 14.7 1.4 3.1 3 1 1 4 4 4 0 Short repeat of unknown function (DUF308) PQ-loop PF04193.14 EDN09305.1 - 0.031 14.1 0.1 0.095 12.5 0.1 2.0 1 0 0 1 1 1 0 PQ loop repeat DUF3262 PF11660.8 EDN09305.1 - 1.6 9.2 5.5 28 5.2 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3262) Fumarate_red_C PF02300.17 EDN09305.1 - 1.7 8.8 6.1 0.18 11.9 0.5 2.2 3 0 0 3 3 3 0 Fumarate reductase subunit C SNARE PF05739.19 EDN09306.1 - 1.2e-12 47.6 2.2 1.4e-12 47.4 0.1 2.2 3 0 0 3 3 3 1 SNARE domain Syntaxin-5_N PF11416.8 EDN09306.1 - 2e-10 39.6 0.3 4.7e-10 38.4 0.3 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 EDN09306.1 - 0.00023 20.9 4.3 0.0014 18.3 0.2 2.5 2 0 0 2 2 2 1 Syntaxin KxDL PF10241.9 EDN09306.1 - 0.0025 18.1 1.3 0.66 10.3 0.0 3.3 3 0 0 3 3 3 1 Uncharacterized conserved protein Syntaxin-18_N PF10496.9 EDN09306.1 - 0.0088 16.3 0.9 0.15 12.3 0.0 2.9 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus DUF4988 PF16378.5 EDN09306.1 - 0.016 14.9 2.7 9.8 5.8 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function DUF4055 PF13264.6 EDN09306.1 - 0.038 14.1 0.6 3.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4055) NPV_P10 PF05531.12 EDN09306.1 - 0.078 13.5 1.7 27 5.3 0.1 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein MCPsignal PF00015.21 EDN09306.1 - 2.7 7.8 8.1 0.26 11.1 1.8 2.3 2 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain XhlA PF10779.9 EDN09308.1 - 0.35 11.1 2.0 0.46 10.7 2.0 1.2 1 0 0 1 1 1 0 Haemolysin XhlA HTH_36 PF13730.6 EDN09309.1 - 0.021 14.8 0.1 0.39 10.7 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Cupin_5 PF06172.11 EDN09310.1 - 1.3e-42 145.3 0.0 1.6e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) RRM_1 PF00076.22 EDN09311.1 - 1.1e-13 50.7 0.0 2.1e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MCM_bind PF09739.9 EDN09311.1 - 6.2 5.1 8.2 9.1 4.6 8.2 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NARP1 PF12569.8 EDN09311.1 - 9.1 5.1 14.7 13 4.5 14.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Apt1 PF10351.9 EDN09314.1 - 7.5e-191 635.1 4.5 7.5e-191 635.1 4.5 2.5 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 EDN09314.1 - 1.3e-174 581.6 0.0 2.3e-174 580.8 0.0 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27 PF10344.9 EDN09314.1 - 3.6e-159 531.6 0.0 7.2e-110 368.5 0.2 2.3 1 1 1 2 2 2 2 Mitochondrial protein from FMP27 DUF2405 PF10293.9 EDN09314.1 - 3.2e-58 196.0 0.2 7.5e-58 194.8 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_GFWDK PF10347.9 EDN09314.1 - 5.5e-49 166.3 0.0 1.3e-48 165.0 0.0 1.7 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.9 EDN09314.1 - 1.3e-33 115.7 0.3 1.7e-32 112.2 0.0 3.1 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain CheZ PF04344.13 EDN09314.1 - 0.068 13.1 0.0 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ B-block_TFIIIC PF04182.12 EDN09316.1 - 2e-21 75.9 0.0 4.6e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC Rhomboid PF01694.22 EDN09319.1 - 8.4e-33 113.5 10.4 8.4e-33 113.5 10.4 2.2 3 0 0 3 3 3 1 Rhomboid family Spt20 PF12090.8 EDN09319.1 - 0.13 11.9 12.2 0.18 11.4 12.2 1.1 1 0 0 1 1 1 0 Spt20 family VKOR PF07884.14 EDN09319.1 - 0.86 9.8 7.9 0.17 12.1 0.3 2.5 2 0 0 2 2 2 0 Vitamin K epoxide reductase family DUF2722 PF10846.8 EDN09319.1 - 2.7 6.8 14.3 3.8 6.3 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 EDN09319.1 - 4.1 7.3 11.9 5.8 6.8 11.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPT_ssu-like PF11779.8 EDN09320.1 - 1.2e-16 60.1 3.3 1.6e-16 59.7 3.3 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Kinetochor_Ybp2 PF08568.10 EDN09321.1 - 9.7e-151 503.4 0.1 7.8e-117 391.4 0.2 2.1 1 1 1 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin Pentapeptide_4 PF13599.6 EDN09322.1 - 1.1e-08 35.2 0.0 0.00012 22.2 0.0 2.7 2 0 0 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 EDN09322.1 - 0.025 14.2 0.0 32 4.3 0.0 3.5 2 1 0 3 3 3 0 Pentapeptide repeats (8 copies) CfAFP PF05264.11 EDN09322.1 - 1.6 8.7 12.4 0.27 11.2 1.0 2.7 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) PLDc_2 PF13091.6 EDN09324.1 - 1.1e-16 61.0 0.0 6e-07 29.4 0.0 3.3 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EDN09324.1 - 1.3e-12 47.3 1.1 1.6e-05 24.9 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif DUF4188 PF13826.6 EDN09326.1 - 2e-36 124.9 0.2 4.6e-36 123.7 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4188) Dehydratase_hem PF13816.6 EDN09326.1 - 9.3e-05 22.0 0.2 0.00049 19.6 0.1 1.5 1 1 1 2 2 2 2 Haem-containing dehydratase DUF2062 PF09835.9 EDN09326.1 - 0.033 14.0 0.9 0.058 13.3 0.6 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Dabb PF07876.12 EDN09326.1 - 0.081 13.6 0.0 0.15 12.7 0.0 1.4 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain Cyanate_lyase PF02560.14 EDN09327.1 - 1.3e-32 111.5 0.0 2.5e-32 110.5 0.0 1.5 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_3 PF01381.22 EDN09327.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix HTH_19 PF12844.7 EDN09327.1 - 0.097 12.7 0.1 0.29 11.2 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain zf-C2H2_4 PF13894.6 EDN09328.1 - 3.5e-10 39.8 29.2 0.13 13.2 0.2 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN09328.1 - 3.2e-09 36.7 26.6 0.023 15.1 0.2 6.4 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDN09328.1 - 2.5e-05 24.4 27.9 0.0043 17.3 0.4 6.2 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDN09328.1 - 8.9e-05 22.4 21.8 0.0063 16.5 0.0 5.6 6 0 0 6 6 6 2 C2H2-type zinc finger zf-met PF12874.7 EDN09328.1 - 0.0036 17.6 25.1 0.053 13.9 0.2 6.2 6 0 0 6 6 6 2 Zinc-finger of C2H2 type Rad50_zn_hook PF04423.14 EDN09328.1 - 0.0048 16.7 1.0 0.0048 16.7 1.0 3.2 4 0 0 4 4 4 1 Rad50 zinc hook motif zf-C2HC_2 PF13913.6 EDN09328.1 - 0.018 15.0 14.8 2.8 7.9 0.1 4.2 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf_Hakai PF18408.1 EDN09328.1 - 0.05 13.3 4.3 0.1 12.3 0.1 3.4 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain PriA_CRR PF18319.1 EDN09328.1 - 0.061 13.3 0.2 0.061 13.3 0.2 3.3 5 0 0 5 5 5 0 PriA DNA helicase Cys-rich region (CRR) domain zf-C2H2_8 PF15909.5 EDN09328.1 - 0.18 12.1 16.7 0.87 9.9 1.3 3.3 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-BED PF02892.15 EDN09328.1 - 1.7 8.7 8.8 2.3 8.3 1.0 3.4 2 1 1 3 3 3 0 BED zinc finger PhnA_Zn_Ribbon PF08274.12 EDN09328.1 - 5.7 7.0 8.0 2.2 8.3 2.5 2.9 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DNA_pol_B PF00136.21 EDN09331.1 - 4.2e-149 497.1 3.6 5.7e-149 496.7 3.6 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDN09331.1 - 3.4e-66 223.7 0.0 1.1e-65 222.0 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDN09331.1 - 5e-18 65.3 5.0 1e-17 64.4 5.0 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta C1_1 PF00130.22 EDN09331.1 - 0.61 10.0 10.0 0.14 12.0 1.2 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Tyrosinase PF00264.20 EDN09332.1 - 4.9e-49 167.6 0.8 8.7e-49 166.8 0.8 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Pkinase PF00069.25 EDN09336.1 - 9e-31 107.2 0.0 4.1e-12 46.0 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09336.1 - 5.1e-13 48.9 0.0 1.2e-05 24.8 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase DCR PF14047.6 EDN09336.1 - 0.11 12.7 0.1 0.27 11.5 0.1 1.5 1 0 0 1 1 1 0 Dppa2/4 conserved region T3SS_basalb_I PF17001.5 EDN09336.1 - 0.23 12.1 0.0 0.52 10.9 0.0 1.5 1 0 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI 3-dmu-9_3-mt PF06983.13 EDN09337.1 - 4.3e-36 124.0 0.6 1.1e-34 119.5 0.6 2.1 1 1 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase Glyco_hydro_47 PF01532.20 EDN09338.1 - 1.7e-173 577.8 0.0 2.1e-173 577.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 EDN09338.1 - 0.16 11.2 0.0 1.8 7.7 0.0 2.4 3 0 0 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Syja_N PF02383.18 EDN09339.1 - 4.9e-57 193.7 0.1 2.2e-37 129.1 0.0 2.5 1 1 1 2 2 2 2 SacI homology domain Tti2 PF10521.9 EDN09340.1 - 6e-98 327.8 3.4 7.8e-98 327.5 3.4 1.1 1 0 0 1 1 1 1 Tti2 family PolyA_pol PF01743.20 EDN09341.1 - 7.8e-26 91.0 0.5 5.6e-25 88.2 0.5 2.4 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EDN09341.1 - 7.1e-07 28.9 0.0 1.7e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EDN09341.1 - 0.0032 17.5 0.0 0.0066 16.5 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative TRAPPC-Trs85 PF12739.7 EDN09342.1 - 5.4e-109 364.8 0.0 1.2e-108 363.7 0.0 1.5 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Snf7 PF03357.21 EDN09343.1 - 3.9e-19 68.9 10.6 3.9e-19 68.9 10.6 1.6 1 1 0 1 1 1 1 Snf7 BLOC1_2 PF10046.9 EDN09343.1 - 0.15 12.4 10.9 4.8 7.5 0.2 4.0 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 EDN09343.1 - 0.33 11.2 7.5 57 4.1 4.8 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) zf-C3HC4_2 PF13923.6 EDN09344.1 - 1.5e-10 40.8 11.8 1.5e-10 40.8 11.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EDN09344.1 - 3.9e-10 39.5 5.0 7.7e-10 38.5 5.0 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 EDN09344.1 - 9.1e-08 31.9 9.9 9.1e-08 31.9 9.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN09344.1 - 6.1e-07 29.2 12.6 6.1e-07 29.2 12.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 EDN09344.1 - 6.8e-07 28.9 0.1 1.5e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 SAP domain zf-RING_5 PF14634.6 EDN09344.1 - 1.3e-06 28.3 15.9 2.5e-06 27.4 12.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain U-box PF04564.15 EDN09344.1 - 1e-05 25.6 0.0 4.4e-05 23.6 0.0 2.1 2 0 0 2 2 1 1 U-box domain zf-RING_UBOX PF13445.6 EDN09344.1 - 1.4e-05 25.0 11.7 1.4e-05 25.0 11.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDN09344.1 - 1.8e-05 24.5 13.8 0.027 14.3 11.4 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDN09344.1 - 6e-05 23.1 12.7 6e-05 23.1 12.7 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EDN09344.1 - 7.9e-05 22.9 13.5 7.9e-05 22.9 13.5 2.3 2 0 0 2 2 2 1 Ring finger domain Mob_synth_C PF06463.13 EDN09344.1 - 0.00018 21.4 4.4 0.00045 20.2 4.4 1.6 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C zf-rbx1 PF12678.7 EDN09344.1 - 0.00035 20.8 9.6 0.0004 20.6 6.0 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EDN09344.1 - 0.011 15.6 6.5 0.011 15.6 6.5 2.7 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EDN09344.1 - 0.029 14.5 6.6 0.029 14.5 6.6 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EDN09344.1 - 0.063 13.3 5.4 0.061 13.4 2.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-WRNIP1_ubi PF18279.1 EDN09344.1 - 1.3 9.8 5.3 0.82 10.5 0.3 3.0 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain CDC27 PF09507.10 EDN09345.1 - 7.8e-134 447.3 18.4 8.8e-134 447.1 18.4 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 SCIMP PF15050.6 EDN09345.1 - 1.5 9.3 4.1 1.2 9.6 0.8 2.4 2 0 0 2 2 2 0 SCIMP protein Ribosomal_S25 PF03297.15 EDN09345.1 - 3.5 7.9 6.2 1.9 8.7 0.1 3.1 3 0 0 3 3 3 0 S25 ribosomal protein Glyco_hydro_125 PF06824.11 EDN09346.1 - 3.4e-174 579.6 0.0 3.9e-174 579.4 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) NMD3 PF04981.13 EDN09347.1 - 1.6e-82 276.6 7.7 2.3e-82 276.1 7.7 1.2 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 EDN09347.1 - 0.8 9.7 11.7 2.9 7.9 0.1 3.0 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYVE_2 PF02318.16 EDN09347.1 - 1.4 9.2 7.9 6.8 6.9 4.3 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Pex2_Pex12 PF04757.14 EDN09349.1 - 1.2e-56 191.8 2.3 1.6e-56 191.5 2.3 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EDN09349.1 - 1.1e-06 28.7 2.8 1.9e-06 27.9 2.8 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDN09349.1 - 3.2e-05 23.8 2.5 6.1e-05 23.0 2.5 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDN09349.1 - 5.6e-05 22.9 1.2 9.5e-05 22.2 1.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN09349.1 - 0.0003 21.1 1.5 0.00046 20.5 1.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDN09349.1 - 0.0005 19.9 1.4 0.00072 19.4 1.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN09349.1 - 0.0013 18.6 1.6 0.0022 17.8 1.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Gryzun PF07919.12 EDN09349.1 - 0.21 10.3 0.0 0.33 9.6 0.0 1.2 1 0 0 1 1 1 0 Gryzun, putative trafficking through Golgi Alpha_GJ PF03229.13 EDN09349.1 - 0.49 11.0 6.9 1.1 9.8 6.9 1.6 1 0 0 1 1 1 0 Alphavirus glycoprotein J Mito_carr PF00153.27 EDN09350.1 - 6.6e-28 96.5 0.2 1.6e-18 66.4 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein WSD PF15613.6 EDN09351.1 - 5e-22 78.2 0.5 5e-22 78.2 0.5 3.7 4 0 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EDN09351.1 - 2e-18 66.5 2.3 4e-18 65.5 2.3 1.5 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EDN09351.1 - 3.8e-09 35.9 0.2 1.2e-08 34.3 0.2 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 WAC_Acf1_DNA_bd PF10537.9 EDN09351.1 - 1e-07 32.4 0.0 5.4e-07 30.1 0.0 2.3 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal CtIP_N PF10482.9 EDN09351.1 - 0.007 16.4 8.5 0.75 9.8 1.5 3.1 2 0 0 2 2 2 2 Tumour-suppressor protein CtIP N-terminal domain DUF3915 PF13054.6 EDN09351.1 - 5.2 7.1 11.6 23 5.0 0.7 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Alg6_Alg8 PF03155.15 EDN09352.1 - 2.8e-164 547.7 23.5 3.3e-164 547.4 23.5 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Lectin_leg-like PF03388.13 EDN09353.1 - 4.2e-20 72.1 0.0 1.7e-18 66.8 0.0 2.1 1 1 1 2 2 2 1 Legume-like lectin family CENP-H PF05837.12 EDN09353.1 - 0.015 15.7 6.1 0.021 15.2 6.1 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Baculo_PEP_C PF04513.12 EDN09353.1 - 0.028 14.5 9.6 0.15 12.1 3.3 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 EDN09353.1 - 0.048 14.1 2.0 1.6 9.2 0.2 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CLZ PF16526.5 EDN09353.1 - 0.049 14.0 5.9 0.19 12.1 0.1 2.8 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phage_Orf51 PF06194.11 EDN09353.1 - 0.056 13.5 0.1 9.2 6.4 0.0 2.6 2 0 0 2 2 2 0 Phage Conserved Open Reading Frame 51 FUSC PF04632.12 EDN09353.1 - 0.06 11.9 0.6 0.079 11.5 0.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1465 PF07323.12 EDN09353.1 - 0.072 12.9 3.9 0.2 11.5 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) DUF948 PF06103.11 EDN09353.1 - 0.15 12.4 2.7 0.29 11.4 1.8 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Uso1_p115_C PF04871.13 EDN09353.1 - 0.16 12.3 3.0 0.23 11.9 2.3 1.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region PspB PF06667.12 EDN09353.1 - 0.16 12.0 6.1 1.4 9.0 2.2 3.2 2 1 1 3 3 3 0 Phage shock protein B IFT57 PF10498.9 EDN09353.1 - 0.19 10.6 5.0 0.28 10.1 5.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Snapin_Pallidin PF14712.6 EDN09353.1 - 0.22 12.0 10.3 0.085 13.3 5.2 2.2 1 1 1 2 2 2 0 Snapin/Pallidin ZapB PF06005.12 EDN09353.1 - 0.26 11.7 10.6 0.061 13.8 7.1 1.7 2 0 0 2 2 2 0 Cell division protein ZapB HSBP1 PF06825.12 EDN09353.1 - 0.31 10.9 3.1 0.71 9.8 0.2 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Apolipoprotein PF01442.18 EDN09353.1 - 0.49 10.2 9.2 0.93 9.3 9.2 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.10 EDN09353.1 - 0.67 10.1 3.5 1.4 9.1 3.5 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family VasL PF12486.8 EDN09353.1 - 0.82 9.5 6.7 12 5.7 3.1 2.2 2 0 0 2 2 2 0 Type VI secretion system, EvfB, or VasL Muted PF14942.6 EDN09353.1 - 1.2 9.5 5.2 3.5 7.9 0.1 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DASH_Dad2 PF08654.10 EDN09353.1 - 3.2 8.2 6.4 3.8 8.0 1.0 2.9 1 1 2 3 3 3 0 DASH complex subunit Dad2 FliT PF05400.13 EDN09353.1 - 8.9 7.2 8.5 2.5 9.0 5.4 1.5 2 0 0 2 2 1 0 Flagellar protein FliT PHD PF00628.29 EDN09354.1 - 4.7e-17 61.6 17.2 9.2e-12 44.7 6.9 2.4 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 EDN09354.1 - 0.014 15.1 7.8 0.2 11.3 1.9 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 EDN09354.1 - 0.64 9.9 8.5 3.1 7.7 1.3 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EDN09354.1 - 1.3 8.7 10.0 1.9 8.1 0.9 3.1 3 0 0 3 3 3 0 PHD-finger Peptidase_M24 PF00557.24 EDN09356.1 - 3e-08 33.6 0.0 6.3e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 Exo_endo_phos PF03372.23 EDN09357.1 - 2.1e-09 37.3 0.1 9.1e-09 35.2 0.1 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SNF5 PF04855.12 EDN09358.1 - 4e-66 223.2 0.1 4e-65 219.9 0.1 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 HEAT_2 PF13646.6 EDN09359.1 - 2.8e-08 34.0 2.9 2.9e-05 24.4 0.5 3.4 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 EDN09359.1 - 3.5e-07 29.9 0.1 0.02 15.1 0.0 5.1 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 EDN09359.1 - 1.9e-05 24.8 0.3 0.027 14.5 0.2 5.1 3 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDN09359.1 - 7.3e-05 22.4 1.6 0.38 10.3 0.0 3.9 4 1 1 5 5 5 2 CLASP N terminal HEAT_EZ PF13513.6 EDN09359.1 - 0.0016 18.9 3.2 0.037 14.5 0.0 4.4 5 0 0 5 5 5 1 HEAT-like repeat DUF3734 PF12536.8 EDN09359.1 - 0.044 14.1 0.1 0.43 10.9 0.0 2.8 1 1 0 1 1 1 0 Patatin phospholipase MFS_1 PF07690.16 EDN09360.1 - 7.2e-39 133.7 39.1 8.4e-39 133.5 39.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN09360.1 - 1.5e-10 40.6 12.3 1.5e-10 40.6 12.3 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter DDE_Tnp_1_7 PF13843.6 EDN09363.1 - 5.9e-43 147.5 0.0 1.4e-40 139.7 0.0 2.9 2 1 0 2 2 2 2 Transposase IS4 DDE_Tnp_1_7 PF13843.6 EDN09364.1 - 2.1e-21 76.6 2.0 7.1e-18 65.0 2.3 2.2 1 1 0 2 2 2 2 Transposase IS4 PHD PF00628.29 EDN09365.1 - 4.4e-09 36.1 5.7 4.4e-09 36.1 5.7 2.6 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 EDN09365.1 - 1.5e-08 34.8 1.0 1.5e-08 34.8 1.0 3.7 4 0 0 4 4 4 1 Ring finger domain zf-rbx1 PF12678.7 EDN09365.1 - 2e-07 31.2 5.3 7.2e-07 29.4 0.7 2.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain PHD_2 PF13831.6 EDN09365.1 - 2.4e-07 30.2 3.7 2.4e-07 30.2 3.7 1.7 2 0 0 2 2 1 1 PHD-finger Prok-RING_4 PF14447.6 EDN09365.1 - 1.7e-06 27.7 5.0 2.7e-05 23.9 1.6 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDN09365.1 - 8.4e-06 25.6 6.1 1.3e-05 25.0 0.3 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDN09365.1 - 1.1e-05 25.1 2.1 1.1e-05 25.1 2.1 3.1 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN09365.1 - 1.4e-05 24.8 0.4 1.4e-05 24.8 0.4 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN09365.1 - 7e-05 22.6 0.6 7e-05 22.6 0.6 3.2 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDN09365.1 - 0.00028 20.9 0.3 0.00028 20.9 0.3 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EDN09365.1 - 0.0023 17.9 1.6 0.0023 17.9 1.6 3.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-PHD-like PF15446.6 EDN09365.1 - 0.031 13.9 0.3 0.031 13.9 0.3 2.4 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-RING_4 PF14570.6 EDN09365.1 - 0.048 13.5 0.2 0.048 13.5 0.2 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EDN09365.1 - 0.26 11.3 5.1 0.94 9.6 0.6 2.9 1 1 1 2 2 2 0 Double zinc ribbon Zn_ribbon_17 PF17120.5 EDN09365.1 - 0.33 10.6 7.7 0.11 12.1 1.2 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EDN09365.1 - 0.55 10.6 10.3 0.71 10.2 1.4 2.8 2 0 0 2 2 2 0 RING-like domain Prok-RING_1 PF14446.6 EDN09365.1 - 1.1 9.2 6.9 12 6.0 2.7 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FYVE PF01363.21 EDN09365.1 - 1.4 9.1 5.0 5.6 7.2 5.0 2.1 1 1 0 1 1 1 0 FYVE zinc finger Ribosomal_L37ae PF01780.19 EDN09367.1 - 5.5e-42 141.8 9.0 6.1e-42 141.6 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EDN09367.1 - 0.00035 20.7 1.3 0.00049 20.2 1.3 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 EDN09367.1 - 0.039 13.9 2.4 0.066 13.2 2.4 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-BED PF02892.15 EDN09367.1 - 0.039 14.0 4.3 2.2 8.4 0.6 2.2 1 1 1 2 2 2 0 BED zinc finger Sacchrp_dh_NADP PF03435.18 EDN09368.1 - 3.4e-13 50.0 0.0 3.5e-11 43.5 0.0 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Ribosomal_S16 PF00886.19 EDN09368.1 - 0.076 13.1 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S16 Pinin_SDK_memA PF04696.13 EDN09369.1 - 2.7e-33 114.8 15.2 2.7e-33 114.8 15.2 2.3 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region Ant_C PF05586.11 EDN09369.1 - 0.72 10.5 4.7 0.8 10.3 1.6 2.6 2 1 0 2 2 2 0 Anthrax receptor C-terminus region PHF5 PF03660.14 EDN09370.1 - 2.6e-52 175.4 9.9 2.9e-52 175.2 9.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EDN09370.1 - 0.67 7.7 7.4 0.69 7.7 7.4 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EDN09370.1 - 1.1 9.4 14.5 2.1 8.4 1.2 3.0 1 1 1 2 2 2 0 Double zinc ribbon Cofilin_ADF PF00241.20 EDN09371.1 - 8.4e-18 64.3 0.0 1.9e-08 34.2 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Mito_carr PF00153.27 EDN09372.1 - 1.4e-43 146.8 0.1 1.6e-22 79.2 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein SBF_like PF13593.6 EDN09373.1 - 2.3e-20 73.2 0.1 1e-19 71.0 0.1 1.8 1 1 1 2 2 2 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 EDN09373.1 - 0.0009 19.0 0.1 0.0012 18.5 0.1 1.1 1 0 0 1 1 1 1 Sodium Bile acid symporter family Pex26 PF07163.12 EDN09374.1 - 0.28 10.5 5.5 0.21 10.9 0.6 2.2 2 0 0 2 2 2 0 Pex26 protein CAF1 PF04857.20 EDN09375.1 - 1.4e-60 205.2 0.0 7.8e-60 202.7 0.0 1.8 1 1 0 1 1 1 1 CAF1 family ribonuclease FAM212 PF15342.6 EDN09375.1 - 0.011 15.6 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 FAM212 family DNA_pol_A_exo1 PF01612.20 EDN09375.1 - 0.057 13.1 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 3'-5' exonuclease MRP-L46 PF11788.8 EDN09376.1 - 1.6e-38 132.1 0.5 2.4e-38 131.5 0.5 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Cript PF10235.9 EDN09377.1 - 5.3e-26 91.0 9.9 5.3e-26 91.0 9.9 1.7 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT CEBP_ZZ PF16366.5 EDN09377.1 - 0.0024 18.1 3.6 0.0024 18.1 3.6 1.8 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain DZR PF12773.7 EDN09377.1 - 0.0066 16.4 15.7 0.044 13.8 9.4 2.8 1 1 2 3 3 3 3 Double zinc ribbon DUF1363 PF07101.11 EDN09377.1 - 0.014 15.6 1.5 0.019 15.2 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1363) zinc_ribbon_2 PF13240.6 EDN09377.1 - 0.027 14.2 12.1 0.7 9.7 3.0 3.4 2 1 1 3 3 3 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EDN09377.1 - 0.079 13.7 14.4 0.035 14.9 8.8 2.6 2 1 0 2 2 2 0 zinc-ribbon family DUF2039 PF10217.9 EDN09377.1 - 3.2 8.1 18.7 1 9.7 12.6 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) PAG PF15347.6 EDN09378.1 - 0.049 12.6 3.6 0.054 12.5 3.6 1.0 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched RVT_1 PF00078.27 EDN09379.1 - 5.7e-07 29.3 0.1 7.6e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1349 PF07081.11 EDN09380.1 - 3.5e-21 75.7 0.0 6.3e-21 74.9 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) AMP-binding PF00501.28 EDN09381.1 - 4.6e-75 252.8 0.0 7.2e-75 252.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EDN09381.1 - 6.4e-68 229.5 0.0 2.6e-34 118.7 0.0 4.6 4 1 0 4 4 4 4 Condensation domain PP-binding PF00550.25 EDN09381.1 - 6.7e-21 74.4 3.1 7.2e-10 39.1 0.4 3.0 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EDN09381.1 - 0.14 13.1 0.0 0.57 11.2 0.0 2.1 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Trp_DMAT PF11991.8 EDN09382.1 - 3.1e-96 323.0 0.0 3.6e-96 322.7 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Abhydrolase_2 PF02230.16 EDN09383.1 - 1e-10 41.8 0.6 4.9e-05 23.2 0.6 3.4 3 1 0 3 3 3 2 Phospholipase/Carboxylesterase AMPK1_CBM PF16561.5 EDN09385.1 - 0.014 15.6 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase NOC3p PF07540.11 EDN09387.1 - 7.9e-29 100.0 0.0 3.7e-28 97.8 0.0 2.2 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 EDN09387.1 - 2.2e-23 83.2 3.6 3.4e-23 82.5 0.4 2.5 2 0 0 2 2 2 1 CBF/Mak21 family UPF0113_N PF17833.1 EDN09388.1 - 2.6e-25 88.8 0.0 3.5e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EDN09388.1 - 1.9e-23 82.5 0.0 3e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EDN09388.1 - 0.099 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 PUA domain Cullin_binding PF03556.15 EDN09389.1 - 1.6e-32 112.5 2.3 2.1e-32 112.1 2.3 1.1 1 0 0 1 1 1 1 Cullin binding BNR PF02012.20 EDN09389.1 - 9.1 6.8 7.1 0.61 10.3 0.9 2.5 3 0 0 3 3 3 0 BNR/Asp-box repeat FAM176 PF14851.6 EDN09390.1 - 0.15 11.8 3.4 0.2 11.3 3.4 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EDN09390.1 - 0.17 10.1 1.8 0.17 10.2 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EDN09390.1 - 0.43 9.9 7.6 0.54 9.5 7.6 1.1 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 EDN09390.1 - 2 8.2 8.3 2.5 7.8 8.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.11 EDN09390.1 - 4 6.2 6.5 5.1 5.8 6.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NESP55 PF06390.12 EDN09390.1 - 5.6 6.5 20.0 0.52 9.9 1.3 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) DNA_pol_phi PF04931.13 EDN09390.1 - 8.9 4.3 10.9 11 4.0 10.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi SWIB PF02201.18 EDN09392.1 - 1.6e-21 76.0 0.0 3e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain RP-C_C PF11800.8 EDN09392.1 - 0.014 15.5 0.6 0.027 14.6 0.6 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region HTH_50 PF18024.1 EDN09392.1 - 0.2 11.3 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Fn_bind PF02986.14 EDN09392.1 - 0.51 10.1 4.6 1.3 8.8 4.6 1.6 1 0 0 1 1 1 0 Fibronectin binding repeat Band_7 PF01145.25 EDN09393.1 - 2e-29 102.9 2.1 2e-29 102.9 2.1 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EDN09393.1 - 0.069 12.8 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Vfa1 PF08432.10 EDN09394.1 - 0.0041 17.5 15.7 0.0056 17.0 15.7 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 SR-25 PF10500.9 EDN09394.1 - 0.016 14.9 28.9 0.028 14.0 28.9 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Zip PF02535.22 EDN09394.1 - 0.018 14.3 0.2 0.024 13.9 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Eapp_C PF10238.9 EDN09394.1 - 0.031 14.3 6.2 0.051 13.7 6.2 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein Rtf2 PF04641.12 EDN09394.1 - 0.061 12.7 16.7 0.094 12.1 16.7 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Defensin_5 PF18251.1 EDN09394.1 - 0.085 13.0 0.5 0.24 11.5 0.5 1.8 1 0 0 1 1 1 0 Fungal defensin Copsin Peptidase_S49_N PF08496.10 EDN09394.1 - 0.1 12.6 14.6 0.18 11.9 14.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Presenilin PF01080.17 EDN09394.1 - 0.11 11.2 2.3 0.13 11.1 2.3 1.2 1 0 0 1 1 1 0 Presenilin Jak1_Phl PF17887.1 EDN09394.1 - 0.13 12.2 8.0 0.24 11.4 8.0 1.4 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Folate_carrier PF01770.18 EDN09394.1 - 0.14 10.9 1.0 0.17 10.6 1.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier EOS1 PF12326.8 EDN09394.1 - 0.15 12.0 1.1 0.6 10.0 1.6 1.8 2 0 0 2 2 2 0 N-glycosylation protein Connexin PF00029.19 EDN09394.1 - 0.2 11.4 8.2 0.27 10.9 8.2 1.2 1 0 0 1 1 1 0 Connexin DUF4770 PF15994.5 EDN09394.1 - 0.45 10.7 9.6 0.63 10.3 9.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) OATP PF03137.20 EDN09394.1 - 0.51 8.6 5.3 0.66 8.2 5.3 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4647 PF15504.6 EDN09394.1 - 0.54 9.3 12.8 0.71 8.9 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) HA2 PF04408.23 EDN09394.1 - 0.93 9.8 4.2 1.8 8.9 4.2 1.4 1 0 0 1 1 1 0 Helicase associated domain (HA2) DUF4551 PF15087.6 EDN09394.1 - 1.2 7.9 8.8 1.5 7.6 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3807 PF12720.7 EDN09394.1 - 2.2 8.5 20.5 3.7 7.8 20.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4337 PF14235.6 EDN09394.1 - 2.3 8.3 9.3 3.4 7.8 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF2828 PF11443.8 EDN09394.1 - 2.5 6.1 10.3 3 5.8 10.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ABC_export PF16962.5 EDN09394.1 - 2.6 6.4 9.0 3.4 6.0 9.0 1.1 1 0 0 1 1 1 0 Putative ABC exporter Ycf1 PF05758.12 EDN09394.1 - 2.6 5.8 13.0 3.3 5.4 13.0 1.1 1 0 0 1 1 1 0 Ycf1 POPLD PF08170.12 EDN09394.1 - 3.5 8.0 7.8 1.5 9.2 5.0 1.9 2 0 0 2 2 1 0 POPLD (NUC188) domain Sec62 PF03839.16 EDN09394.1 - 3.7 7.0 15.1 5.5 6.4 15.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 V_ATPase_I PF01496.19 EDN09394.1 - 4.2 5.2 6.5 5.5 4.8 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family O-antigen_lig PF13425.6 EDN09394.1 - 4.3 6.0 5.0 5.3 5.7 5.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein EMC3_TMCO1 PF01956.16 EDN09394.1 - 5.1 6.8 6.9 7.5 6.3 6.9 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like YL1 PF05764.13 EDN09394.1 - 7.7 6.5 26.3 11 6.1 26.3 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Peroxin-13_N PF04088.13 EDN09394.1 - 8.3 6.7 5.7 14 5.9 5.7 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region PTR2 PF00854.21 EDN09397.1 - 3.5e-93 312.6 4.1 7.1e-93 311.6 4.1 1.4 1 1 0 1 1 1 1 POT family Phage_holin_4_2 PF04020.13 EDN09397.1 - 8.9 7.1 13.6 0.98 10.1 0.3 3.6 3 0 0 3 3 3 0 Mycobacterial 4 TMS phage holin, superfamily IV Glyco_hydro_18 PF00704.28 EDN09398.1 - 6.8e-82 275.7 0.2 8.4e-82 275.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 ubiquitin PF00240.23 EDN09399.1 - 4.6e-34 116.0 0.6 7.9e-34 115.2 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EDN09399.1 - 7.3e-27 93.3 1.7 7.3e-27 93.3 1.7 2.0 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EDN09399.1 - 2.6e-16 59.2 0.7 4.9e-16 58.3 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDN09399.1 - 2.7e-05 24.5 0.3 0.00013 22.4 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDN09399.1 - 0.00071 19.7 0.7 0.0016 18.5 0.7 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDN09399.1 - 0.0048 17.2 1.0 0.0076 16.6 0.1 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDN09399.1 - 0.0054 16.6 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain IBR PF01485.21 EDN09399.1 - 0.009 16.2 0.3 0.015 15.5 0.3 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain DUF2407 PF10302.9 EDN09399.1 - 0.013 16.1 0.9 0.018 15.6 0.9 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDN09399.1 - 0.02 14.9 1.0 5.9 7.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain zf-C2H2 PF00096.26 EDN09400.1 - 1.6e-09 37.7 17.4 0.0075 16.7 7.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN09400.1 - 8.1e-07 29.2 12.8 0.0036 17.7 0.2 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN09400.1 - 9.7e-07 29.1 15.5 0.084 13.8 5.8 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDN09400.1 - 0.11 12.5 0.1 0.11 12.5 0.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EDN09400.1 - 0.15 11.8 6.8 7.1 6.5 3.0 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type AT_hook PF02178.19 EDN09400.1 - 1 9.4 4.0 2.8 8.1 4.0 1.8 1 0 0 1 1 1 0 AT hook motif Ribonuclease_T2 PF00445.18 EDN09401.1 - 9.8e-40 136.7 0.2 1.4e-39 136.2 0.2 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family 4HBT_3 PF13622.6 EDN09402.1 - 6.6e-43 147.7 0.0 7.8e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF155 PF02582.14 EDN09403.1 - 5.9e-50 169.8 0.0 8.7e-50 169.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 FeoB_associated PF12669.7 EDN09403.1 - 0.17 12.3 0.1 0.29 11.5 0.1 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Clathrin PF00637.20 EDN09404.1 - 5e-18 65.3 2.3 5.2e-17 62.1 0.0 2.7 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EDN09404.1 - 0.19 12.0 0.7 0.77 10.1 0.1 2.2 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 FAM220 PF15487.6 EDN09405.1 - 0.047 13.3 0.9 0.053 13.2 0.9 1.1 1 0 0 1 1 1 0 FAM220 family CP2 PF04516.15 EDN09407.1 - 2.5e-76 256.0 0.0 3.9e-76 255.4 0.0 1.3 1 0 0 1 1 1 1 CP2 transcription factor DUF4567 PF15131.6 EDN09409.1 - 0.077 13.1 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4567) Metallopep PF12044.8 EDN09410.1 - 1.5e-110 369.7 0.0 1.4e-95 320.5 0.0 2.1 2 0 0 2 2 2 2 Putative peptidase family Pkinase_fungal PF17667.1 EDN09411.1 - 3.8e-43 147.8 0.0 4.9e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN09411.1 - 0.078 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Med3 PF11593.8 EDN09412.1 - 4.7 6.3 5.1 2.4 7.3 2.6 1.6 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal GST_C_2 PF13410.6 EDN09413.1 - 1.6e-07 31.2 0.3 4.9e-07 29.7 0.2 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDN09413.1 - 1e-05 25.8 0.0 2.3e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDN09413.1 - 4.3e-05 23.7 0.0 0.00011 22.4 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EDN09413.1 - 0.0038 17.5 0.0 0.0083 16.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 EDN09413.1 - 0.0045 17.7 0.0 0.0074 17.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 EDN09413.1 - 0.095 12.9 0.2 0.23 11.7 0.1 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDN09413.1 - 0.1 12.8 0.0 0.33 11.2 0.0 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 EDN09414.1 - 2.4e-20 72.8 20.9 5.7e-17 61.7 14.9 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1211 PF06736.11 EDN09414.1 - 0.12 12.9 0.4 0.12 12.9 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1211) Multi_Drug_Res PF00893.19 EDN09414.1 - 0.89 10.3 6.5 1.7 9.4 1.7 2.9 2 0 0 2 2 2 0 Small Multidrug Resistance protein DNA_ligase_A_M PF01068.21 EDN09416.1 - 2e-49 168.0 0.0 8.8e-47 159.4 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDN09416.1 - 4.3e-36 124.8 0.0 7.2e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EDN09416.1 - 4.8e-14 52.8 0.5 1.5e-13 51.2 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DJ-1_PfpI PF01965.24 EDN09416.1 - 3.4e-05 23.7 0.0 7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family RINT1_TIP1 PF04437.13 EDN09417.1 - 6e-181 602.7 0.1 6e-181 602.7 0.1 1.6 2 0 0 2 2 2 1 RINT-1 / TIP-1 family DUF2064 PF09837.9 EDN09417.1 - 0.14 12.0 1.0 0.31 10.9 1.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) PAS_7 PF12860.7 EDN09417.1 - 0.15 12.2 0.7 8.3 6.6 0.6 2.5 2 0 0 2 2 2 0 PAS fold Mce4_CUP1 PF11887.8 EDN09417.1 - 0.2 11.1 3.0 0.35 10.3 3.0 1.3 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative Nup54 PF13874.6 EDN09417.1 - 2.2 8.4 9.2 6.4 6.9 9.2 1.7 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Pyridoxal_deC PF00282.19 EDN09418.1 - 2.8e-78 263.2 0.0 3.8e-78 262.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EDN09418.1 - 7.6e-06 25.4 0.0 9.1e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EDN09418.1 - 9.2e-06 24.8 0.0 1.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V PUF PF00806.19 EDN09419.1 - 1.7e-08 33.7 0.0 3.7 7.4 0.0 6.9 7 0 0 7 7 7 4 Pumilio-family RNA binding repeat RCC1 PF00415.18 EDN09420.1 - 2e-29 101.9 4.0 7e-07 29.8 0.0 7.5 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDN09420.1 - 2.5e-12 46.2 0.9 3.6e-10 39.4 0.1 7.9 9 0 0 9 9 9 4 Regulator of chromosome condensation (RCC1) repeat CI-B14_5a PF07347.12 EDN09420.1 - 0.22 11.4 0.8 0.56 10.1 0.8 1.6 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Sec34 PF04136.15 EDN09421.1 - 2.3e-48 163.8 2.1 2.3e-48 163.8 2.1 2.3 3 0 0 3 3 3 1 Sec34-like family Exo70 PF03081.15 EDN09421.1 - 0.24 10.4 3.4 0.39 9.7 0.0 2.5 3 1 0 3 3 3 0 Exo70 exocyst complex subunit ANAPC4 PF12896.7 EDN09421.1 - 1.3 8.5 4.6 18 4.7 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 4 DIL PF01843.19 EDN09421.1 - 1.9 8.8 4.5 8.8 6.7 0.9 3.4 4 0 0 4 4 4 0 DIL domain Pkinase PF00069.25 EDN09422.1 - 1.3e-59 201.8 0.0 2.3e-59 200.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09422.1 - 5e-42 144.0 0.0 7.4e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN09422.1 - 5e-11 42.4 0.0 1.6e-07 31.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EDN09422.1 - 0.0012 17.8 0.2 0.0041 16.0 0.2 2.0 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDN09422.1 - 0.0032 16.9 0.0 0.0062 15.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2 PF00096.26 EDN09426.1 - 2.3e-05 24.6 14.5 4.3e-05 23.7 2.8 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN09426.1 - 2.9e-05 24.3 6.4 3.4e-05 24.1 3.3 2.4 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN09426.1 - 0.00014 22.4 1.7 0.00014 22.4 1.7 2.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDN09426.1 - 0.0015 18.7 0.7 0.0048 17.1 0.7 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EDN09426.1 - 0.0016 18.7 1.7 0.005 17.1 1.7 1.9 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EDN09426.1 - 0.0044 17.0 1.3 0.01 15.8 1.3 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-TRAF PF02176.18 EDN09426.1 - 0.56 10.9 4.2 0.92 10.3 2.2 2.2 2 0 0 2 2 2 0 TRAF-type zinc finger Forkhead PF00250.18 EDN09428.1 - 8.8e-19 67.6 0.6 2.4e-17 63.0 0.6 2.4 1 1 0 1 1 1 1 Forkhead domain FHA PF00498.26 EDN09428.1 - 2.4e-06 27.8 0.0 4.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 EDN09429.1 - 6.9e-124 413.7 0.0 8.6e-124 413.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase MauJ PF17419.2 EDN09429.1 - 0.18 11.3 0.0 0.39 10.1 0.0 1.5 1 0 0 1 1 1 0 Methylamine utilization protein MauJ DUF3699 PF12480.8 EDN09431.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3699) Metallopep PF12044.8 EDN09433.1 - 4.5e-120 401.1 0.0 6e-120 400.7 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.6 EDN09433.1 - 0.0063 17.0 0.7 0.012 16.2 0.1 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EDN09433.1 - 0.026 13.5 0.4 0.05 12.5 0.4 1.4 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_5 PF13688.6 EDN09433.1 - 0.074 13.2 0.2 0.15 12.2 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EDN09433.1 - 0.097 12.6 0.3 0.18 11.7 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like ING PF12998.7 EDN09435.1 - 1.4e-06 28.9 0.0 3.9e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Rbsn PF11464.8 EDN09435.1 - 0.016 15.0 0.9 0.038 13.7 0.9 1.6 1 0 0 1 1 1 0 Rabenosyn Rab binding domain PRIMA1 PF16101.5 EDN09437.1 - 0.5 10.4 6.9 0.78 9.8 6.9 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DEC-1_N PF04625.13 EDN09437.1 - 8.4 5.3 5.7 10 5.0 5.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region EB1 PF03271.17 EDN09438.1 - 4.1e-17 62.1 0.7 7.5e-17 61.3 0.7 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EDN09438.1 - 3.2e-06 27.3 0.2 5.9e-06 26.4 0.2 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Herpes_UL6 PF01763.16 EDN09438.1 - 0.0078 14.8 0.0 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus UL6 like CH_2 PF06294.11 EDN09438.1 - 0.0086 16.2 0.1 0.014 15.5 0.1 1.3 1 0 0 1 1 1 1 CH-like domain in sperm protein WD40 PF00400.32 EDN09439.1 - 3.6e-29 100.4 11.8 2.9e-06 27.9 0.1 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat F-box-like PF12937.7 EDN09439.1 - 2.7e-08 33.6 1.3 3.4e-08 33.2 0.2 1.8 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 EDN09439.1 - 0.0001 22.5 0.6 9.5 6.6 0.0 4.9 2 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EDN09439.1 - 0.00012 21.9 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 F-box PQQ_2 PF13360.6 EDN09439.1 - 0.00031 20.4 0.4 0.059 12.9 0.2 2.3 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.21 EDN09439.1 - 0.00092 19.0 0.5 7.4 6.7 0.0 3.6 3 0 0 3 3 3 1 PQQ enzyme repeat WD40_like PF17005.5 EDN09439.1 - 0.0018 17.7 0.0 0.045 13.1 0.0 2.7 3 1 0 3 3 3 1 WD40-like domain F-box PF00646.33 EDN09439.1 - 0.0029 17.5 0.0 0.0076 16.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain DUF5046 PF16465.5 EDN09439.1 - 0.011 15.1 0.1 0.57 9.6 0.0 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF5046) PQQ_3 PF13570.6 EDN09439.1 - 0.088 13.3 0.9 94 3.7 0.0 4.5 5 0 0 5 5 5 0 PQQ-like domain GFO_IDH_MocA PF01408.22 EDN09440.1 - 1.7e-09 38.5 0.0 3.1e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold LigB PF02900.18 EDN09440.1 - 0.08 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Cation_ATPase_C PF00689.21 EDN09442.1 - 1.6e-44 151.8 9.2 1.6e-44 151.8 9.2 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EDN09442.1 - 5.4e-37 127.1 0.3 5.4e-37 127.1 0.3 2.9 5 0 0 5 5 5 1 E1-E2 ATPase Cation_ATPase PF13246.6 EDN09442.1 - 4.2e-23 81.2 0.0 7.7e-23 80.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDN09442.1 - 3.2e-14 53.7 0.0 1.3e-13 51.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN09442.1 - 8.5e-09 35.0 0.1 8.9e-08 31.7 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDN09442.1 - 9.8e-05 22.2 0.2 0.0024 17.7 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase LptF_LptG PF03739.14 EDN09442.1 - 0.0018 17.2 1.3 0.0069 15.3 0.8 2.0 2 0 0 2 2 2 1 Lipopolysaccharide export system permease LptF/LptG DUF1774 PF08611.10 EDN09442.1 - 0.035 14.4 3.2 0.39 11.1 0.2 2.7 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) Ferlin_C PF16165.5 EDN09442.1 - 0.1 12.5 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Ferlin C-terminus P16-Arc PF04699.14 EDN09443.1 - 1.5e-43 148.8 0.0 1.7e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) DUF1720 PF08226.11 EDN09443.1 - 0.023 15.1 0.4 0.038 14.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1720) Methyltransf_11 PF08241.12 EDN09444.1 - 4.7e-09 36.8 0.0 9.9e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN09444.1 - 2e-07 31.0 0.0 3.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09444.1 - 1.9e-06 28.5 0.0 4.4e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN09444.1 - 9.1e-06 26.3 0.0 3.4e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09444.1 - 0.0081 16.0 0.0 0.064 13.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain XRN1_DBM PF18245.1 EDN09444.1 - 0.0091 15.9 0.6 0.022 14.7 0.6 1.6 1 0 0 1 1 1 1 5-3 exonuclease XRN1 DCP1-binding motif Ubie_methyltran PF01209.18 EDN09444.1 - 0.25 10.7 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Dynactin_p62 PF05502.13 EDN09445.1 - 2.7e-173 577.1 0.0 3.4e-173 576.8 0.0 1.0 1 0 0 1 1 1 1 Dynactin p62 family Ribosomal_S7e PF01251.18 EDN09446.1 - 1.1e-78 263.2 0.0 1.3e-78 263.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e XFP_N PF09364.10 EDN09447.1 - 1.3e-152 507.8 0.0 1.8e-152 507.4 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 EDN09447.1 - 2.3e-77 259.0 0.0 4.6e-77 258.1 0.0 1.5 2 0 0 2 2 2 1 XFP C-terminal domain XFP PF03894.15 EDN09447.1 - 7.6e-74 247.2 0.0 1.2e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase TPP_enzyme_C PF02775.21 EDN09447.1 - 0.014 15.2 0.2 0.033 14.0 0.2 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Acetate_kinase PF00871.17 EDN09448.1 - 1.6e-88 297.1 0.0 1.9e-88 296.8 0.0 1.1 1 0 0 1 1 1 1 Acetokinase family Ras PF00071.22 EDN09452.1 - 1.9e-55 186.9 0.0 3.3e-55 186.1 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDN09452.1 - 2.7e-34 118.0 0.0 3.7e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN09452.1 - 1.8e-13 50.3 0.0 3.3e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDN09452.1 - 8.5e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDN09452.1 - 0.0003 20.8 0.0 0.00045 20.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDN09452.1 - 0.00044 19.8 0.0 0.00091 18.8 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EDN09452.1 - 0.0026 18.2 0.0 0.0042 17.5 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDN09452.1 - 0.015 15.2 0.1 2.5 8.0 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase AAA_16 PF13191.6 EDN09454.1 - 2e-10 41.3 0.1 4.4e-10 40.2 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EDN09454.1 - 0.0044 16.6 0.1 0.017 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDN09454.1 - 0.031 14.6 0.3 0.21 11.8 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDN09454.1 - 0.034 13.7 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 EDN09454.1 - 0.078 13.4 0.0 0.14 12.5 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EDN09454.1 - 0.099 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 EDN09454.1 - 0.11 12.5 0.1 0.47 10.4 0.0 2.1 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) CLU PF13236.6 EDN09456.1 - 1.9e-74 250.2 0.0 3.4e-74 249.4 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EDN09456.1 - 8.9e-53 178.9 0.0 2.4e-52 177.5 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EDN09456.1 - 3.3e-25 88.2 7.7 2.8e-12 46.7 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EDN09456.1 - 1.6e-24 86.1 0.5 4.8e-24 84.5 0.5 1.9 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EDN09456.1 - 2.4e-20 71.8 1.8 3.5e-05 23.5 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDN09456.1 - 0.00062 19.7 5.2 0.37 11.0 0.2 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDN09456.1 - 0.0025 17.9 6.2 0.068 13.4 0.7 4.0 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF727 PF05303.12 EDN09456.1 - 0.0042 17.1 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Ferrochelatase PF00762.19 EDN09456.1 - 0.0054 15.9 0.0 0.0098 15.0 0.0 1.3 1 0 0 1 1 1 1 Ferrochelatase TPR_17 PF13431.6 EDN09456.1 - 0.5 10.9 3.8 2.4e+02 2.4 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat BCS1_N PF08740.11 EDN09459.1 - 2.6e-48 164.5 0.8 3.6e-48 164.0 0.8 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN09459.1 - 9.2e-17 61.7 0.0 1.7e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN09459.1 - 4.2e-05 24.0 0.2 0.00025 21.5 0.0 2.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 EDN09459.1 - 0.0022 18.2 0.0 0.012 15.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDN09459.1 - 0.0034 17.1 0.0 0.019 14.7 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.13 EDN09459.1 - 0.0039 16.4 0.0 0.0073 15.5 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EDN09459.1 - 0.0086 16.6 0.0 0.023 15.2 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EDN09459.1 - 0.015 15.6 0.0 0.099 12.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDN09459.1 - 0.04 13.9 0.0 0.11 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EDN09459.1 - 0.044 14.3 0.0 0.097 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDN09459.1 - 0.048 13.2 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EDN09459.1 - 0.067 13.6 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EDN09459.1 - 0.14 11.9 0.0 1.4 8.6 0.0 2.4 2 1 0 3 3 3 0 AAA domain Rad17 PF03215.15 EDN09459.1 - 0.14 12.0 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain Viral_helicase1 PF01443.18 EDN09459.1 - 0.16 11.7 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EDN09459.1 - 0.2 11.4 0.0 0.42 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cpn60_TCP1 PF00118.24 EDN09461.1 - 1.4e-175 584.6 1.1 1.6e-175 584.5 1.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1168 PF06658.12 EDN09462.1 - 1.3e-40 138.4 13.9 1.8e-40 137.9 13.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Lyase_catalyt PF09093.11 EDN09462.1 - 0.16 11.1 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Lyase, catalytic Peptidase_S49_N PF08496.10 EDN09462.1 - 0.9 9.6 6.9 1.3 9.0 6.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TMEM214 PF10151.9 EDN09462.1 - 4.8 5.5 5.3 5.9 5.2 5.3 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Kinesin PF00225.23 EDN09464.1 - 1.4e-57 195.1 0.0 2.2e-57 194.5 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDN09464.1 - 3.3e-13 49.8 0.0 2.5e-12 47.0 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding KLRAQ PF10205.9 EDN09464.1 - 0.015 15.5 0.9 0.042 14.1 0.9 1.8 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein bZIP_2 PF07716.15 EDN09464.1 - 0.043 13.9 1.8 0.12 12.5 1.8 1.8 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.15 EDN09464.1 - 0.09 12.6 3.7 0.053 13.3 0.6 2.2 2 0 0 2 2 2 0 Septum formation initiator Cnn_1N PF07989.11 EDN09464.1 - 0.11 12.6 2.5 0.55 10.4 2.5 2.1 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 bMG6 PF17962.1 EDN09464.1 - 0.17 12.0 0.8 0.53 10.5 0.7 1.8 1 1 0 1 1 1 0 Bacterial macroglobulin domain 6 TPR_19 PF14559.6 EDN09465.1 - 0.055 14.0 0.2 24 5.5 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN09465.1 - 0.084 13.7 0.8 8 7.6 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDN09465.1 - 0.31 10.7 0.8 2 8.2 0.8 2.5 1 0 0 1 1 1 0 TPR repeat ChAPs PF09295.10 EDN09466.1 - 8.2e-154 512.4 0.0 1.1e-153 512.0 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 EDN09466.1 - 1.3e-06 28.1 1.4 0.0064 16.5 0.3 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN09466.1 - 1.2e-05 25.8 0.8 0.22 12.1 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDN09466.1 - 1.4e-05 24.7 0.8 0.2 11.6 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDN09466.1 - 1.5e-05 24.8 1.6 0.023 14.9 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDN09466.1 - 0.00067 20.3 9.4 8.9 7.4 0.0 5.4 4 2 3 7 7 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDN09466.1 - 0.0013 18.8 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDN09466.1 - 0.0019 18.1 1.8 0.49 10.5 0.1 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDN09466.1 - 0.0051 16.1 1.9 0.21 10.8 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDN09466.1 - 0.013 15.7 4.1 8 6.8 0.1 4.1 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDN09466.1 - 0.48 11.2 1.8 1.4e+02 3.4 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SWIRM-assoc_2 PF16496.5 EDN09467.1 - 0.83 8.4 12.1 1 8.2 12.1 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Stm1_N PF09598.10 EDN09467.1 - 2.1 9.2 20.3 0.38 11.6 3.1 2.4 2 0 0 2 2 2 0 Stm1 ERCC4 PF02732.15 EDN09468.1 - 9.6e-26 90.9 0.0 1.9e-25 89.9 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain DUF4364 PF14277.6 EDN09468.1 - 0.0095 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) E1-E2_ATPase PF00122.20 EDN09469.1 - 5.5e-49 166.1 0.3 1.1e-46 158.7 0.0 2.5 2 0 0 2 2 2 2 E1-E2 ATPase HMA PF00403.26 EDN09469.1 - 2.1e-40 137.0 2.7 2.5e-11 43.8 0.0 4.7 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EDN09469.1 - 8.9e-34 117.6 0.1 2.7e-33 116.0 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDN09469.1 - 7.5e-07 29.1 1.3 0.0003 20.6 0.4 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDN09469.1 - 0.00047 20.6 0.0 0.0012 19.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3386 PF11866.8 EDN09469.1 - 0.21 11.1 0.0 0.38 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3386) TFIIB PF00382.19 EDN09470.1 - 5.8e-33 112.8 2.4 7.5e-18 64.4 0.1 2.7 3 0 0 3 3 3 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EDN09470.1 - 5.8e-26 90.8 1.7 3.7e-25 88.2 0.0 2.8 3 1 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EDN09470.1 - 0.00013 21.4 2.4 0.00032 20.2 2.4 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EDN09470.1 - 0.00027 20.7 0.2 0.63 9.8 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain IBR PF01485.21 EDN09470.1 - 0.048 13.9 1.2 0.12 12.6 0.8 1.8 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain TPT PF03151.16 EDN09472.1 - 7.6e-17 61.6 22.3 9.2e-17 61.3 22.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDN09472.1 - 0.01 16.0 29.6 0.069 13.3 10.5 2.1 2 0 0 2 2 2 0 EamA-like transporter family UAA PF08449.11 EDN09472.1 - 0.025 13.8 23.9 0.075 12.2 23.9 1.7 1 1 0 1 1 1 0 UAA transporter family ArsD PF06953.11 EDN09473.1 - 0.12 12.8 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD NAD_binding_8 PF13450.6 EDN09474.1 - 2e-07 31.1 0.1 4.4e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EDN09474.1 - 3.8e-05 23.2 0.0 6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EDN09474.1 - 0.0059 15.9 0.1 0.009 15.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EDN09474.1 - 0.0099 15.1 0.4 0.02 14.2 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN09474.1 - 0.012 14.8 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EDN09474.1 - 0.019 14.2 0.1 0.031 13.5 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDN09474.1 - 0.054 13.1 0.1 0.072 12.7 0.1 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDN09474.1 - 0.055 12.5 0.5 0.098 11.7 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EDN09474.1 - 0.071 12.5 0.0 0.098 12.0 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EDN09474.1 - 0.13 10.9 0.1 0.2 10.3 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 EDN09474.1 - 0.21 11.9 0.0 0.39 11.0 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Pkinase PF00069.25 EDN09476.1 - 2.6e-63 213.9 0.0 3.4e-63 213.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09476.1 - 2.4e-30 105.7 0.0 4e-29 101.7 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDN09476.1 - 6e-05 22.5 0.0 9.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDN09476.1 - 0.00039 19.5 0.1 0.00062 18.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDN09476.1 - 0.0029 17.0 0.1 0.016 14.5 0.0 2.3 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EDN09476.1 - 0.0036 17.3 0.1 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDN09476.1 - 0.0066 16.1 0.1 0.76 9.4 0.0 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 CAP_N PF01213.19 EDN09477.1 - 2.5 7.5 10.8 1.3 8.4 1.6 2.4 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Seryl_tRNA_N PF02403.22 EDN09478.1 - 1.7e-09 37.9 1.3 6.6e-08 32.7 1.3 2.2 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain tRNA-synt_2b PF00587.25 EDN09478.1 - 2.9e-06 27.4 0.0 5.7e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) FUSC PF04632.12 EDN09478.1 - 0.017 13.7 0.3 0.024 13.2 0.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Spc7 PF08317.11 EDN09478.1 - 0.049 12.5 2.0 0.075 11.9 2.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein betaPIX_CC PF16523.5 EDN09478.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 betaPIX coiled coil Fib_alpha PF08702.10 EDN09478.1 - 0.18 12.0 0.1 0.18 12.0 0.1 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ING PF12998.7 EDN09478.1 - 0.74 10.4 3.5 1.3 9.7 3.5 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding ABC_tran_CTD PF16326.5 EDN09478.1 - 0.87 9.9 4.8 11 6.4 5.0 2.4 1 1 1 2 2 2 0 ABC transporter C-terminal domain Ax_dynein_light PF10211.9 EDN09478.1 - 0.88 9.5 5.3 2.4 8.1 5.3 1.7 1 1 0 1 1 1 0 Axonemal dynein light chain FapA PF03961.13 EDN09478.1 - 1.2 7.6 3.3 2 6.9 3.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 EDN09478.1 - 3.5 6.4 4.7 5 5.9 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RasGAP_C PF03836.15 EDN09478.1 - 4.4 7.5 6.9 5.2 7.2 2.1 2.0 1 1 1 2 2 2 0 RasGAP C-terminus APG6_N PF17675.1 EDN09478.1 - 8.2 7.0 11.1 90 3.6 10.2 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Cytochrom_B561 PF03188.16 EDN09479.1 - 2e-05 24.7 1.6 2e-05 24.7 1.6 1.9 1 1 1 2 2 2 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EDN09479.1 - 0.0034 17.5 2.0 0.0041 17.3 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4079) DUF3999 PF13163.6 EDN09479.1 - 0.0041 16.4 0.1 0.0044 16.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3999) AzlD PF05437.12 EDN09479.1 - 0.019 15.2 1.1 0.024 14.8 1.1 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) SdpI PF13630.6 EDN09479.1 - 0.17 12.0 0.3 0.17 12.0 0.3 2.0 1 1 1 2 2 2 0 SdpI/YhfL protein family Allantoicase PF03561.15 EDN09481.1 - 1.8e-86 287.4 0.0 2e-44 151.1 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat HATPase_c PF02518.26 EDN09482.1 - 3e-31 108.2 0.0 8.7e-31 106.7 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDN09482.1 - 1.5e-21 76.7 0.1 3.5e-21 75.5 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EDN09482.1 - 1.4e-18 66.7 0.1 7.8e-18 64.3 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 EDN09482.1 - 8.3e-12 45.6 0.0 2.2e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 GAF domain AAA_16 PF13191.6 EDN09482.1 - 1.2e-11 45.3 0.1 7.8e-11 42.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain GAF PF01590.26 EDN09482.1 - 5.3e-09 36.8 0.0 1.9e-08 35.0 0.0 2.0 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.25 EDN09482.1 - 2.3e-07 30.5 0.0 1e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain GAF_3 PF13492.6 EDN09482.1 - 5.2e-05 23.6 0.0 0.00016 22.0 0.0 1.9 1 0 0 1 1 1 1 GAF domain NACHT PF05729.12 EDN09482.1 - 8.3e-05 22.6 0.0 0.094 12.6 0.1 2.7 2 0 0 2 2 2 2 NACHT domain HATPase_c_3 PF13589.6 EDN09482.1 - 0.00071 19.4 0.2 0.0033 17.3 0.0 2.3 3 0 0 3 3 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MeaB PF03308.16 EDN09482.1 - 0.004 16.2 0.0 0.008 15.2 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EDN09482.1 - 0.0085 15.3 0.4 0.23 10.6 0.4 2.5 1 1 0 1 1 1 1 NB-ARC domain TPR_2 PF07719.17 EDN09482.1 - 0.034 14.2 7.8 8.4 6.8 0.1 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDN09482.1 - 1 10.1 0.0 1 10.1 0.0 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Pkinase_fungal PF17667.1 EDN09483.1 - 2.6e-195 648.9 0.0 5.7e-143 476.6 0.0 3.1 2 1 1 3 3 3 3 Fungal protein kinase Pkinase PF00069.25 EDN09483.1 - 5.6e-07 29.2 0.0 1.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09483.1 - 0.046 13.0 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN09483.1 - 0.078 12.9 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family DRIM PF07539.12 EDN09483.1 - 0.23 9.7 0.0 0.83 7.9 0.0 1.7 2 0 0 2 2 2 0 Down-regulated in metastasis Rnf-Nqr PF02508.14 EDN09485.1 - 0.077 13.0 7.8 0.43 10.5 7.2 2.1 1 1 1 2 2 2 0 Rnf-Nqr subunit, membrane protein 7TMR-DISM_7TM PF07695.11 EDN09485.1 - 0.16 11.8 8.5 0.21 11.4 3.0 2.2 1 1 0 2 2 2 0 7TM diverse intracellular signalling DUF3826 PF12875.7 EDN09487.1 - 0.075 13.2 0.2 0.082 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) RNase_H PF00075.24 EDN09489.1 - 2.3e-13 50.5 0.0 4.4e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN09489.1 - 0.0037 17.1 0.1 0.027 14.3 0.1 2.2 1 1 0 1 1 1 1 Reverse transcriptase-like zf-RVT PF13966.6 EDN09489.1 - 0.026 15.2 0.2 0.07 13.8 0.2 1.7 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase zf-C3HC4_3 PF13920.6 EDN09493.1 - 0.00021 21.1 10.2 0.00032 20.5 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Fez1 PF06818.15 EDN09493.1 - 0.012 16.0 1.2 0.018 15.5 1.2 1.2 1 0 0 1 1 1 0 Fez1 zf-C3HC4_2 PF13923.6 EDN09493.1 - 0.02 14.7 7.5 0.036 13.9 7.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4618 PF15397.6 EDN09493.1 - 0.026 14.0 1.1 0.033 13.6 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) UPF0242 PF06785.11 EDN09493.1 - 0.026 14.6 2.8 0.041 14.0 2.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EDN09493.1 - 0.035 14.2 1.1 0.06 13.4 1.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Interferon PF00143.19 EDN09493.1 - 0.052 13.7 0.1 0.075 13.2 0.1 1.2 1 0 0 1 1 1 0 Interferon alpha/beta domain DUF5446 PF17522.2 EDN09493.1 - 0.057 13.6 1.2 0.095 12.9 1.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5446) zf-C3HC4 PF00097.25 EDN09493.1 - 0.06 13.2 7.7 0.11 12.4 7.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tox-REase-9 PF15650.6 EDN09493.1 - 0.06 13.6 0.0 0.29 11.4 0.0 1.9 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 9 zf-RING_5 PF14634.6 EDN09493.1 - 0.084 12.9 7.4 0.15 12.0 7.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain HAUS-augmin3 PF14932.6 EDN09493.1 - 0.084 12.4 1.1 0.11 12.0 1.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Rota_NSP4 PF01452.16 EDN09493.1 - 0.11 12.1 1.2 0.2 11.3 1.2 1.4 1 0 0 1 1 1 0 Rotavirus non structural protein DUF1664 PF07889.12 EDN09493.1 - 0.12 12.5 1.0 0.18 11.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) APC_N_CC PF16689.5 EDN09493.1 - 0.16 12.1 1.0 0.26 11.4 1.0 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain DUF4542 PF15075.6 EDN09493.1 - 0.42 11.0 1.6 2.6 8.4 1.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4542) zf-RING_2 PF13639.6 EDN09493.1 - 1.1 9.7 11.8 1.9 8.9 11.8 1.4 1 0 0 1 1 1 0 Ring finger domain DUF3435 PF11917.8 EDN09494.1 - 3e-36 125.3 0.0 9.7e-36 123.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) RT_RNaseH PF17917.1 EDN09496.1 - 4e-26 91.3 0.0 9.3e-26 90.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN09496.1 - 3.8e-25 87.8 0.0 8.9e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN09496.1 - 5.3e-19 68.6 0.0 8.9e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN09496.1 - 2.8e-13 50.1 0.0 8.6e-13 48.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EDN09496.1 - 3.5e-13 49.4 0.0 6.8e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN09496.1 - 3.9e-06 26.7 0.1 8.8e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MscS_porin PF12795.7 EDN09496.1 - 0.003 17.2 16.0 0.0071 15.9 16.0 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Chromo_shadow PF01393.19 EDN09496.1 - 0.013 15.6 0.1 0.028 14.5 0.1 1.6 1 0 0 1 1 1 0 Chromo shadow domain Spc7 PF08317.11 EDN09496.1 - 0.019 13.9 11.1 0.056 12.3 11.1 1.8 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 EDN09496.1 - 0.022 14.8 0.9 0.06 13.4 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 EDN09496.1 - 0.047 11.6 0.2 0.069 11.1 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3552 PF12072.8 EDN09496.1 - 0.077 12.4 17.2 0.15 11.5 16.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) YabA PF06156.13 EDN09496.1 - 0.081 13.6 0.1 0.081 13.6 0.1 2.5 1 1 1 2 2 2 0 Initiation control protein YabA zf-H2C2 PF09337.10 EDN09496.1 - 0.097 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger gag_pre-integrs PF13976.6 EDN09496.1 - 0.16 11.8 0.1 0.37 10.7 0.1 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain IFT57 PF10498.9 EDN09496.1 - 0.19 10.6 7.4 0.34 9.9 7.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 APG6_N PF17675.1 EDN09496.1 - 0.21 12.1 15.1 0.68 10.5 15.1 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region HMMR_N PF15905.5 EDN09496.1 - 0.62 9.5 8.8 1.1 8.6 8.8 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF4407 PF14362.6 EDN09496.1 - 0.9 8.8 11.4 2 7.7 11.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 EDN09496.1 - 1.5 8.3 9.1 4.2 6.8 9.1 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit Jnk-SapK_ap_N PF09744.9 EDN09496.1 - 5.5 7.2 13.8 16 5.7 13.8 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 EDN09496.1 - 5.6 7.0 12.5 13 5.9 12.5 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding NQRA_SLBB PF11973.8 EDN09497.1 - 0.089 13.4 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 NQRA C-terminal domain HATPase_c PF02518.26 EDN09498.1 - 2.2e-23 82.9 2.1 9.5e-23 80.8 0.2 2.6 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EDN09498.1 - 4.5e-17 61.9 0.0 1.6e-16 60.1 0.0 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EDN09498.1 - 4.1e-05 23.8 0.1 0.044 14.1 0.0 2.8 2 0 0 2 2 2 2 PAS fold DUF4364 PF14277.6 EDN09498.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) RVT_1 PF00078.27 EDN09499.1 - 8.8e-23 81.0 0.0 1.3e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 EDN09499.1 - 0.13 13.0 0.8 0.4 11.4 0.3 2.0 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase SIKE PF05769.11 EDN09500.1 - 0.047 13.6 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 SIKE family DDE_Tnp_1_7 PF13843.6 EDN09501.1 - 8.5e-21 74.6 0.0 2.2e-20 73.3 0.0 1.6 1 1 0 1 1 1 1 Transposase IS4 RasGEF PF00617.19 EDN09502.1 - 9e-45 153.0 4.5 1e-44 152.9 1.5 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EDN09502.1 - 4.8e-12 46.0 0.4 1.4e-11 44.6 0.4 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif DIL PF01843.19 EDN09503.1 - 4.3e-30 104.0 1.0 8.1e-30 103.2 1.0 1.5 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 EDN09503.1 - 3.4e-14 53.2 0.0 8.7e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN09503.1 - 3.5e-12 46.3 0.0 4.7e-07 30.0 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EDN09503.1 - 4.2e-09 36.4 0.0 0.0015 18.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EDN09503.1 - 7.6e-09 35.9 0.1 4.6e-05 23.9 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN09503.1 - 5.5e-07 29.4 0.1 0.016 15.6 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat RabGAP-TBC PF00566.18 EDN09506.1 - 1.5e-33 116.3 0.0 2.3e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mo25 PF08569.11 EDN09507.1 - 1.5e-132 441.9 0.1 1.7e-132 441.7 0.1 1.0 1 0 0 1 1 1 1 Mo25-like DUF5361 PF17318.2 EDN09508.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5361) Pox_F15 PF04596.12 EDN09508.1 - 0.14 12.0 1.1 1 9.1 0.3 2.1 2 0 0 2 2 2 0 Poxvirus protein F15 Methyltransf_25 PF13649.6 EDN09509.1 - 3.2e-10 40.6 0.0 7.1e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDN09509.1 - 4.3e-08 32.9 0.0 7.5e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EDN09509.1 - 5.4e-08 33.4 0.0 1.1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09509.1 - 5.4e-07 29.5 0.0 9.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN09509.1 - 3.1e-05 23.9 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDN09509.1 - 0.00025 20.6 0.0 0.00043 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EDN09509.1 - 0.0017 17.4 0.0 0.0027 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 EDN09509.1 - 0.0018 18.2 0.0 0.0031 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09509.1 - 0.016 15.9 0.0 0.034 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EDN09509.1 - 0.049 12.9 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EDN09509.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TehB PF03848.14 EDN09509.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 EDN09509.1 - 0.21 11.3 0.0 0.44 10.3 0.0 1.4 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cir_N PF10197.9 EDN09510.1 - 6.2e-06 26.3 0.9 6.2e-06 26.3 0.9 5.8 7 1 0 7 7 7 1 N-terminal domain of CBF1 interacting co-repressor CIR AAA PF00004.29 EDN09511.1 - 7.1e-44 149.4 0.4 4.7e-39 133.8 0.0 2.7 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN09511.1 - 3e-10 39.8 0.0 7.6e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 EDN09511.1 - 8.7e-10 38.2 0.1 1.1e-08 34.8 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 CDC48_N PF02359.18 EDN09511.1 - 5.2e-09 36.2 0.0 1.4e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.6 EDN09511.1 - 1.7e-06 28.4 0.0 0.0001 22.6 0.0 2.9 3 1 0 3 3 2 1 AAA domain AAA_2 PF07724.14 EDN09511.1 - 1.2e-05 25.5 0.0 4.7e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDN09511.1 - 5.8e-05 23.1 0.0 0.0019 18.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN09511.1 - 0.00014 22.3 0.0 0.0012 19.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EDN09511.1 - 0.00053 20.5 0.1 0.015 15.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EDN09511.1 - 0.0015 18.0 0.1 0.0052 16.2 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EDN09511.1 - 0.0027 17.5 0.1 0.044 13.5 0.1 2.6 2 1 1 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EDN09511.1 - 0.0038 17.6 0.0 0.043 14.2 0.0 2.3 2 0 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 EDN09511.1 - 0.005 16.6 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDN09511.1 - 0.0076 16.3 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDN09511.1 - 0.0081 15.7 0.1 0.025 14.1 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region TIP49 PF06068.13 EDN09511.1 - 0.0088 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain ATPase PF06745.13 EDN09511.1 - 0.011 15.1 0.1 0.021 14.2 0.1 1.4 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.27 EDN09511.1 - 0.018 15.5 0.1 0.042 14.4 0.1 1.5 1 0 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.17 EDN09511.1 - 0.037 13.7 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 EDN09511.1 - 0.047 13.5 0.1 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDN09511.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDN09511.1 - 0.085 12.9 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Vps4_C PF09336.10 EDN09511.1 - 0.098 12.7 0.0 0.31 11.1 0.0 1.8 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain AAA_19 PF13245.6 EDN09511.1 - 0.13 12.6 0.0 0.64 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDN09511.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain KxDL PF10241.9 EDN09513.1 - 1.7e-27 95.5 2.0 2.2e-27 95.2 2.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF4407 PF14362.6 EDN09513.1 - 0.016 14.5 1.4 0.017 14.5 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dodecin PF07311.12 EDN09513.1 - 0.038 14.3 0.3 0.074 13.3 0.3 1.4 1 0 0 1 1 1 0 Dodecin Spc7 PF08317.11 EDN09513.1 - 0.041 12.8 3.4 0.049 12.5 3.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HAD_2 PF13419.6 EDN09514.1 - 2.6e-10 40.7 0.0 3.1e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN09514.1 - 0.038 14.3 0.0 0.044 14.1 0.0 1.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Pkinase_fungal PF17667.1 EDN09515.1 - 2.3e-143 477.9 0.0 3.1e-143 477.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN09515.1 - 2.6e-07 30.3 0.1 4.4e-07 29.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09515.1 - 0.048 12.9 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN09515.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Bunya_NS-S_2 PF03231.13 EDN09515.1 - 0.18 10.6 0.0 0.26 10.0 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-S Arginosuc_synth PF00764.19 EDN09516.1 - 3.3e-110 369.0 0.0 9.5e-110 367.5 0.0 1.6 1 1 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EDN09516.1 - 0.027 14.0 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EDN09516.1 - 0.051 12.4 0.0 0.07 11.9 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Peptidase_M13_N PF05649.13 EDN09517.1 - 1e-80 272.3 0.0 9.5e-80 269.1 0.0 2.0 1 1 1 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.21 EDN09517.1 - 1.8e-63 213.8 0.2 2.9e-63 213.2 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M13 MAD PF05557.13 EDN09518.1 - 4e-63 213.9 65.7 1.4e-54 185.6 67.2 2.3 2 1 0 2 2 2 2 Mitotic checkpoint protein Tropomyosin_1 PF12718.7 EDN09518.1 - 0.0004 20.6 17.1 0.0004 20.6 17.1 6.9 2 2 3 6 6 6 1 Tropomyosin like Septum_form PF13845.6 EDN09518.1 - 0.093 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Septum formation WD40_alt PF14077.6 EDN09518.1 - 0.4 10.6 4.8 3.3 7.6 0.6 3.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif muHD PF10291.9 EDN09519.1 - 6.5e-93 311.0 0.3 9.1e-93 310.5 0.3 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Muted PF14942.6 EDN09519.1 - 0.01 16.2 4.9 0.023 15.0 4.9 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Laminin_II PF06009.12 EDN09519.1 - 0.018 15.0 2.8 0.046 13.7 2.8 1.6 1 0 0 1 1 1 0 Laminin Domain II Alanine_zipper PF11839.8 EDN09519.1 - 0.03 14.7 6.6 0.075 13.4 6.6 1.7 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein CheZ PF04344.13 EDN09519.1 - 2.5 8.0 5.7 4.7 7.1 5.7 1.4 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Pkinase PF00069.25 EDN09520.1 - 1.1e-47 162.6 0.0 1.5e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09520.1 - 4.6e-20 72.0 0.0 7e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN09520.1 - 1.7e-05 24.9 0.1 0.19 11.6 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN09520.1 - 0.00024 20.5 0.0 0.00066 19.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like KIX_2 PF16987.5 EDN09520.1 - 0.00076 19.4 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 KIX domain Pkinase_fungal PF17667.1 EDN09520.1 - 0.0046 15.8 0.0 0.0069 15.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF4852 PF16144.5 EDN09520.1 - 0.024 14.7 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4852) Kdo PF06293.14 EDN09520.1 - 0.037 13.4 0.1 0.059 12.7 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDN09520.1 - 0.14 11.8 0.0 0.61 9.7 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EDN09520.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL SH3_9 PF14604.6 EDN09521.1 - 7.6e-09 35.3 0.0 1.2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDN09521.1 - 2e-06 27.3 0.0 3.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDN09521.1 - 1.2e-05 24.8 0.0 2.2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 EDN09521.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Podoplanin SIT PF15330.6 EDN09521.1 - 0.21 12.0 4.8 31 5.1 0.0 2.5 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT CYYR1 PF10873.8 EDN09521.1 - 1.2 9.5 0.0 1.2 9.5 0.0 4.7 5 1 1 6 6 6 0 Cysteine and tyrosine-rich protein 1 PA PF02225.22 EDN09521.1 - 3.9 7.6 6.7 3.9 7.6 2.9 2.6 2 0 0 2 2 2 0 PA domain OPT PF03169.15 EDN09522.1 - 3.5e-93 313.3 11.7 4.3e-93 313.0 11.7 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein TraQ PF09679.10 EDN09522.1 - 0.0059 16.5 0.6 0.0059 16.5 0.6 2.3 2 0 0 2 2 2 1 Type-F conjugative transfer system pilin chaperone (TraQ) OPT PF03169.15 EDN09523.1 - 5e-34 117.9 0.0 6.1e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Rav1p_C PF12234.8 EDN09524.1 - 6.4e-273 907.0 0.0 8.5e-273 906.5 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal Clathrin-link PF09268.10 EDN09524.1 - 0.16 11.3 0.4 0.92 8.9 0.1 2.3 2 0 0 2 2 2 0 Clathrin, heavy-chain linker Sfi1 PF08457.10 EDN09525.1 - 1.2e-134 450.0 70.2 3.5e-133 445.2 57.6 2.1 1 1 1 2 2 2 2 Sfi1 spindle body protein DUF267 PF03268.14 EDN09525.1 - 0.28 10.0 1.1 0.56 9.0 1.1 1.4 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF267 NDUF_B7 PF05676.13 EDN09526.1 - 0.0013 18.4 1.7 0.49 10.2 0.2 2.0 1 1 1 2 2 2 2 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CX9C PF16860.5 EDN09526.1 - 0.013 15.5 1.9 0.018 15.0 1.9 1.2 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDN09526.1 - 0.047 13.8 4.1 0.22 11.7 0.6 2.1 2 0 0 2 2 2 0 CHCH domain tRNA-synt_1 PF00133.22 EDN09527.1 - 4.3e-166 553.7 0.0 9e-111 371.0 0.0 3.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDN09527.1 - 4.6e-24 85.1 0.0 1.3e-23 83.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDN09527.1 - 1.7e-08 33.7 0.0 0.00016 20.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) Get5_C PF18514.1 EDN09527.1 - 0.026 14.3 0.3 0.13 12.0 0.1 2.4 2 0 0 2 2 2 0 Get5 C-terminal domain Uso1_p115_head PF04869.14 EDN09528.1 - 2.4e-110 368.5 0.0 8e-110 366.8 0.0 2.0 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EDN09528.1 - 5.2e-18 65.6 25.7 5.2e-18 65.6 25.7 3.6 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region Filament PF00038.21 EDN09528.1 - 0.00094 18.9 39.8 0.0019 17.8 39.8 1.5 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.11 EDN09528.1 - 0.011 16.0 32.5 0.011 16.0 32.5 2.5 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 EDN09528.1 - 0.029 11.9 45.9 0.043 11.3 45.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Arm PF00514.23 EDN09528.1 - 0.13 12.4 3.2 16 5.7 0.0 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 EDN09528.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.6 3 1 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Spc7 PF08317.11 EDN09528.1 - 2.4 7.0 47.1 0.85 8.4 22.3 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF4094 PF13334.6 EDN09528.1 - 3.5 8.1 16.4 2.3 8.7 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) T7SS_ESX_EspC PF10824.8 EDN09528.1 - 4.7 7.8 8.5 2.2 8.8 2.9 2.8 2 1 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm ZnuA PF01297.17 EDN09528.1 - 5.7 6.3 13.2 8.5 5.7 2.0 2.6 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic XRN_N PF03159.18 EDN09529.1 - 1.8e-102 341.9 1.1 3.9e-101 337.5 0.0 2.1 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EDN09529.1 - 6.9e-39 134.0 0.6 1.4e-38 133.1 0.0 1.7 2 0 0 2 2 2 1 Xrn1 helical domain zf-CCHC PF00098.23 EDN09529.1 - 0.0017 18.4 1.7 0.0035 17.4 1.7 1.5 1 0 0 1 1 1 1 Zinc knuckle Atrophin-1 PF03154.15 EDN09529.1 - 0.0073 14.7 9.0 0.011 14.1 9.0 1.2 1 0 0 1 1 1 1 Atrophin-1 family Late_protein_L2 PF00513.18 EDN09530.1 - 0.0041 16.2 0.2 0.0056 15.8 0.2 1.2 1 0 0 1 1 1 1 Late Protein L2 XRN_M PF17846.1 EDN09530.1 - 0.051 12.5 0.0 0.087 11.8 0.0 1.3 1 0 0 1 1 1 0 Xrn1 helical domain DDE_3 PF13358.6 EDN09531.1 - 2.3e-07 30.7 1.1 3.6e-07 30.0 1.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease EPSP_synthase PF00275.20 EDN09532.1 - 1.4e-126 422.5 0.0 2.3e-126 421.9 0.0 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EDN09532.1 - 1.6e-100 335.6 0.0 2.3e-100 335.1 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EDN09532.1 - 4.6e-58 197.2 0.0 8.4e-58 196.3 0.0 1.5 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 EDN09532.1 - 6.4e-25 87.2 0.0 1.9e-24 85.7 0.0 1.9 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 EDN09532.1 - 4.3e-07 30.2 0.4 2.9e-06 27.5 0.0 2.5 3 1 0 3 3 3 1 Shikimate kinase Fe-ADH_2 PF13685.6 EDN09532.1 - 2.5e-06 27.4 0.0 5.9e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase SDH_C PF18317.1 EDN09532.1 - 0.0002 21.0 0.1 0.00086 19.0 0.0 2.0 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EDN09532.1 - 0.02 14.9 0.0 0.058 13.5 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF2795 PF11387.8 EDN09532.1 - 0.11 12.7 0.0 0.75 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) Exo5 PF09810.9 EDN09533.1 - 9e-122 407.1 0.0 1.7e-120 402.9 0.0 2.2 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease Mpv17_PMP22 PF04117.12 EDN09533.1 - 2.7e-14 53.1 0.3 6.7e-14 51.9 0.3 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family PDDEXK_1 PF12705.7 EDN09533.1 - 0.028 14.3 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily Histone PF00125.24 EDN09534.1 - 2.2e-51 173.7 2.2 2.4e-51 173.5 2.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDN09534.1 - 5.9e-06 26.6 0.0 9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDN09534.1 - 4.6e-05 23.5 0.4 7.4e-05 22.8 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EDN09534.1 - 0.0011 19.6 1.0 0.0013 19.3 1.0 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDN09534.1 - 0.0032 17.7 0.3 0.0065 16.7 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDN09534.1 - 0.023 14.8 0.2 0.042 13.9 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EDN09535.1 - 2.4e-06 27.6 0.1 2.7e-06 27.4 0.1 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EDN09535.1 - 6e-05 23.1 0.1 7.2e-05 22.9 0.1 1.0 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EDN09535.1 - 0.00029 21.1 0.1 0.0003 21.1 0.1 1.0 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EDN09535.1 - 0.00055 20.3 0.1 0.00056 20.3 0.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDN09535.1 - 0.0079 16.5 0.0 0.0095 16.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDN09535.1 - 0.008 16.2 0.0 0.0081 16.2 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDN09535.1 - 0.11 12.5 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Bromodomain associated TackOD1 PF18551.1 EDN09537.1 - 0.91 9.2 4.5 1.4 8.6 4.5 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 RT_RNaseH PF17917.1 EDN09538.1 - 5.1e-35 119.9 0.0 5.1e-34 116.7 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN09538.1 - 3.2e-31 108.6 0.0 5.6e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN09538.1 - 6.3e-24 83.9 0.3 1.4e-12 47.5 0.0 3.1 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN09538.1 - 6.6e-07 29.3 6.0 9.6e-06 25.6 6.0 2.5 1 1 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 EDN09538.1 - 1.6e-05 24.7 1.2 3.2e-05 23.8 1.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EDN09538.1 - 0.044 13.6 0.4 0.13 12.1 0.4 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN09538.1 - 0.15 11.8 0.8 0.33 10.7 0.8 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EDN09538.1 - 0.15 11.8 0.3 0.33 10.7 0.3 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Retrotran_gag_2 PF14223.6 EDN09538.1 - 0.26 11.0 1.6 0.67 9.6 1.6 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type zf-C2H2 PF00096.26 EDN09543.1 - 1.3e-08 34.9 13.1 0.00012 22.4 1.4 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN09543.1 - 2.8e-05 24.6 11.0 0.021 15.6 1.1 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger Sin_N PF04801.13 EDN09543.1 - 0.00031 20.1 16.5 0.00031 20.1 16.5 2.5 3 0 0 3 3 3 1 Sin-like protein conserved region TERB2 PF15101.6 EDN09543.1 - 0.0087 16.1 14.7 0.0087 16.1 14.7 3.3 3 0 0 3 3 3 1 Telomere-associated protein TERB2 zf-Di19 PF05605.12 EDN09543.1 - 0.68 10.3 6.3 0.57 10.5 1.7 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding MPM1 PF17234.2 EDN09543.1 - 1.5 9.1 19.7 0.41 10.9 12.7 2.7 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Plasmodium_Vir PF05795.11 EDN09543.1 - 3.3 7.1 15.3 0.31 10.4 5.5 2.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF4746 PF15928.5 EDN09543.1 - 6.8 6.0 15.0 0.14 11.5 7.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) zf-H2C2_2 PF13465.6 EDN09543.1 - 7.3 7.2 16.2 4.8 7.8 1.3 4.1 4 0 0 4 4 4 0 Zinc-finger double domain Glyco_transf_22 PF03901.17 EDN09544.1 - 1.5e-86 291.3 22.1 1.7e-86 291.1 22.1 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Gar1 PF04410.14 EDN09545.1 - 8.3e-48 162.1 1.6 1.9e-47 160.9 1.6 1.6 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region MamL-1 PF09596.10 EDN09545.1 - 0.0052 17.0 1.2 0.02 15.2 1.2 2.0 1 0 0 1 1 1 1 MamL-1 domain PRP3 PF08572.10 EDN09546.1 - 1.4e-72 244.1 2.3 2.5e-72 243.2 2.3 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EDN09546.1 - 3.7e-47 160.1 0.5 3.7e-47 160.1 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) GET2 PF08690.10 EDN09546.1 - 4.4 6.9 10.9 3.9 7.1 0.6 3.1 3 0 0 3 3 3 0 GET complex subunit GET2 RNA_pol_Rpb1_5 PF04998.17 EDN09547.1 - 4.8e-82 275.4 0.0 8.7e-82 274.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EDN09547.1 - 4.7e-26 91.9 3.1 1.4e-24 87.1 1.4 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EDN09547.1 - 1.9e-25 90.0 0.0 5.7e-25 88.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDN09547.1 - 8.6e-24 84.2 0.0 3.6e-23 82.2 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDN09547.1 - 7.5e-18 64.5 0.0 2.5e-17 62.8 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Nop14 PF04147.12 EDN09547.1 - 2.3 6.3 16.7 4.8 5.3 16.7 1.4 1 0 0 1 1 1 0 Nop14-like family HBB PF06777.11 EDN09548.1 - 2e-48 164.6 3.3 9.2e-45 152.7 0.9 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EDN09548.1 - 5.4e-45 153.6 0.0 2e-44 151.7 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EDN09548.1 - 2.5e-33 115.2 6.0 7.9e-19 67.9 3.5 2.9 2 1 1 3 3 3 2 DEAD_2 Remorin_C PF03763.13 EDN09548.1 - 1.6 8.7 5.3 4 7.4 5.3 1.6 1 0 0 1 1 1 0 Remorin, C-terminal region LCM PF04072.14 EDN09550.1 - 2.1e-20 73.5 0.0 5.8e-20 72.0 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Utp12 PF04003.12 EDN09550.1 - 0.26 11.6 0.9 16 5.8 0.1 3.0 3 0 0 3 3 3 0 Dip2/Utp12 Family zf-RING_5 PF14634.6 EDN09551.1 - 6.2e-05 22.9 3.5 0.00012 21.9 3.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Torus PF16131.5 EDN09551.1 - 0.00029 21.5 0.6 0.16 12.7 0.1 2.4 2 0 0 2 2 2 2 Torus domain zf-C3HC4_3 PF13920.6 EDN09551.1 - 0.00031 20.6 4.8 0.0009 19.1 4.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN09551.1 - 0.00064 20.0 5.2 0.00064 20.0 5.2 2.4 3 0 0 3 3 2 1 Ring finger domain zf-CCCH_3 PF15663.5 EDN09551.1 - 0.0011 19.2 1.4 0.0076 16.5 0.2 2.4 2 0 0 2 2 2 1 Zinc-finger containing family zf-C3HC4 PF00097.25 EDN09551.1 - 0.0012 18.6 4.8 0.0025 17.6 4.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN09551.1 - 0.0063 16.5 2.4 0.011 15.8 1.5 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDN09551.1 - 0.0098 15.7 4.2 0.022 14.6 4.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-CCCH PF00642.24 EDN09551.1 - 0.045 13.7 14.7 0.051 13.5 1.9 3.3 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EDN09551.1 - 0.051 14.1 20.2 0.42 11.2 5.0 3.5 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-C3HC4_4 PF15227.6 EDN09551.1 - 0.31 11.2 5.0 0.78 10.0 5.0 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 EDN09551.1 - 0.94 9.4 21.4 1.7 8.6 0.8 3.5 3 0 0 3 3 3 0 CCCH-type zinc finger zf-C3HC4_2 PF13923.6 EDN09551.1 - 2 8.3 8.3 12 5.9 8.3 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ist1 PF03398.14 EDN09552.1 - 1e-30 106.8 0.9 2e-15 57.1 1.7 2.1 2 0 0 2 2 2 2 Regulator of Vps4 activity in the MVB pathway DUF4637 PF15470.6 EDN09552.1 - 0.77 9.5 0.0 0.77 9.5 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4637) DUF4501 PF14946.6 EDN09555.1 - 0.067 13.3 0.9 0.093 12.8 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) Ins_beta PF03488.14 EDN09555.1 - 0.29 11.2 2.8 3.8 7.6 2.8 2.3 1 1 0 1 1 1 0 Nematode insulin-related peptide beta type Sulfotransfer_4 PF17784.1 EDN09556.1 - 1.4e-09 38.2 0.0 1.5e-09 38.0 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Clat_adaptor_s PF01217.20 EDN09557.1 - 1.6e-55 186.9 2.1 1.9e-55 186.7 2.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Acyltransferase PF01553.21 EDN09559.1 - 3.3e-06 26.8 0.0 4.2e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase TP_methylase PF00590.20 EDN09560.1 - 5e-24 85.4 0.1 8.9e-24 84.6 0.1 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TFIID-18kDa PF02269.16 EDN09561.1 - 4.8e-32 109.8 0.3 5.2e-31 106.5 0.2 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Cnd1_N PF12922.7 EDN09561.1 - 0.033 14.1 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term TAFII28 PF04719.14 EDN09561.1 - 0.069 13.2 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Aminotran_1_2 PF00155.21 EDN09562.1 - 7.3e-56 189.9 0.0 8.6e-56 189.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 EDN09562.1 - 0.019 13.9 0.0 0.026 13.4 0.0 1.1 1 0 0 1 1 1 0 Allinase Cys_Met_Meta_PP PF01053.20 EDN09562.1 - 0.028 13.0 0.1 0.053 12.1 0.0 1.4 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme EF-hand_10 PF14788.6 EDN09562.1 - 0.094 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 EF hand BIR PF00653.21 EDN09563.1 - 6e-25 87.7 0.1 1.2e-24 86.7 0.1 1.5 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain F-box PF00646.33 EDN09565.1 - 0.0035 17.2 0.0 0.0077 16.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain SPC12 PF06645.13 EDN09565.1 - 0.14 12.3 0.2 0.23 11.6 0.2 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) RNA_pol_Rpb5_C PF01191.19 EDN09567.1 - 3.4e-33 113.3 0.1 6.2e-33 112.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EDN09567.1 - 1.3e-28 99.4 0.1 2.4e-28 98.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EDN09567.1 - 0.0072 16.3 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease Myb_DNA-bind_4 PF13837.6 EDN09567.1 - 0.11 12.9 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain EzrA PF06160.12 EDN09568.1 - 0.00051 18.4 14.3 0.00051 18.4 14.3 3.0 2 1 1 3 3 3 2 Septation ring formation regulator, EzrA DUF1664 PF07889.12 EDN09568.1 - 0.064 13.3 19.1 0.14 12.2 0.6 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) RTBV_P12 PF06361.11 EDN09568.1 - 0.13 12.7 2.3 2.3 8.6 0.1 3.5 2 1 1 3 3 3 0 Rice tungro bacilliform virus P12 protein Speriolin_C PF15059.6 EDN09568.1 - 0.38 10.9 2.3 1.7 8.7 0.3 2.6 2 0 0 2 2 2 0 Speriolin C-terminus Baculo_PEP_C PF04513.12 EDN09568.1 - 0.54 10.3 12.9 1 9.4 1.8 3.7 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4191 PF13829.6 EDN09568.1 - 0.73 9.1 2.6 0.54 9.6 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) DUF4407 PF14362.6 EDN09568.1 - 1.3 8.3 55.0 0.36 10.1 15.3 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Hpt PF01627.23 EDN09568.1 - 2.7 8.3 8.1 1.4 9.2 0.2 3.9 2 1 1 3 3 3 0 Hpt domain Hemagglutinin PF00509.18 EDN09568.1 - 5 5.4 12.5 0.055 11.9 2.6 2.3 3 0 0 3 3 3 0 Haemagglutinin Helicase_IV_N PF12462.8 EDN09568.1 - 9.1 6.2 12.6 0.55 10.2 0.2 3.3 2 1 1 3 3 3 0 DNA helicase IV / RNA helicase N terminal adh_short PF00106.25 EDN09569.1 - 3.1e-09 36.6 0.1 4.4e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN09569.1 - 7e-05 22.5 0.1 9.4e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltr_RsmB-F PF01189.17 EDN09571.1 - 2.2e-07 30.7 0.0 3.2e-06 26.9 0.0 2.2 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PLAC8 PF04749.17 EDN09572.1 - 6e-25 88.1 16.6 7e-25 87.9 16.6 1.1 1 0 0 1 1 1 1 PLAC8 family Aldolase_II PF00596.21 EDN09573.1 - 2e-33 115.9 0.0 4.4e-32 111.5 0.0 2.1 1 1 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DEAD PF00270.29 EDN09574.1 - 1.2e-43 148.9 0.1 2.1e-43 148.1 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN09574.1 - 7.1e-20 71.4 0.3 3.4e-19 69.2 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN09574.1 - 1e-05 25.6 0.0 1.9e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDN09574.1 - 0.0044 16.2 0.0 0.0075 15.5 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 EDN09574.1 - 0.034 13.5 0.0 0.065 12.5 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain Ank_2 PF12796.7 EDN09575.1 - 1.8e-37 127.8 17.0 8.5e-08 32.7 0.0 11.5 7 4 4 12 12 12 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN09575.1 - 3.3e-23 81.7 16.9 4.9e-06 27.0 0.0 12.8 12 2 2 14 14 14 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN09575.1 - 6.5e-15 53.7 24.4 0.27 11.9 0.0 18.0 24 0 0 24 24 24 3 Ankyrin repeat Ank PF00023.30 EDN09575.1 - 7.8e-07 29.3 25.3 0.38 11.3 0.1 12.9 14 3 0 14 14 14 2 Ankyrin repeat Ank_5 PF13857.6 EDN09575.1 - 4.6e-05 23.6 16.1 0.13 12.6 0.0 8.7 9 3 4 13 13 13 3 Ankyrin repeats (many copies) Adenylsucc_synt PF00709.21 EDN09576.1 - 1.6e-166 554.4 0.0 1.8e-166 554.3 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DnaJ PF00226.31 EDN09577.1 - 4.8e-17 61.8 1.8 6.4e-11 42.2 0.3 2.7 2 0 0 2 2 2 2 DnaJ domain Fungal_trans PF04082.18 EDN09578.1 - 0.0083 15.2 0.0 0.019 14.0 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EDN09579.1 - 2.1e-18 66.4 18.2 2.1e-16 59.8 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GTP1_OBG PF01018.22 EDN09580.1 - 5.1e-39 133.4 3.9 2.6e-28 98.5 4.6 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EDN09580.1 - 3e-23 82.1 0.0 6.4e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN09580.1 - 9.7e-08 31.7 0.1 2e-07 30.7 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 EDN09580.1 - 0.042 14.3 0.7 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 ABC transporter MeaB PF03308.16 EDN09580.1 - 0.1 11.6 0.0 0.96 8.4 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 EDN09580.1 - 0.26 10.7 0.0 0.61 9.5 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family Cupin_8 PF13621.6 EDN09581.1 - 2.6e-16 60.1 0.0 5.6e-16 59.0 0.0 1.5 1 1 0 1 1 1 1 Cupin-like domain Homeobox_KN PF05920.11 EDN09582.1 - 3.2e-16 59.0 0.6 6.6e-16 57.9 0.6 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EDN09582.1 - 0.00018 21.3 0.1 0.00046 20.0 0.1 1.7 1 0 0 1 1 1 1 Homeodomain zf-C2H2 PF00096.26 EDN09582.1 - 0.00091 19.6 16.2 0.63 10.6 2.7 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN09582.1 - 0.003 18.3 2.8 0.003 18.3 2.8 5.0 5 0 0 5 5 5 2 C2H2-type zinc finger HTH_Tnp_Tc5 PF03221.16 EDN09582.1 - 0.08 13.0 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain zf-C2H2_3rep PF18868.1 EDN09582.1 - 0.43 11.3 4.5 0.25 12.0 0.3 2.4 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-H2C2_2 PF13465.6 EDN09582.1 - 0.61 10.6 6.7 2.5 8.7 0.1 3.7 4 0 0 4 4 4 0 Zinc-finger double domain UQ_con PF00179.26 EDN09583.1 - 7e-12 45.2 0.1 1.2e-11 44.5 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDN09583.1 - 0.1 12.9 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 RWD domain 2OG-FeII_Oxy_2 PF13532.6 EDN09585.1 - 6.1e-20 72.2 0.0 8.6e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CUE PF02845.16 EDN09585.1 - 0.0083 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 CUE domain WD40 PF00400.32 EDN09586.1 - 7.5e-13 48.7 13.9 0.0065 17.3 0.1 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat MFS_1 PF07690.16 EDN09587.1 - 2.3e-26 92.6 23.3 3.2e-26 92.1 23.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN09587.1 - 1.5e-17 63.6 4.6 2e-17 63.2 4.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EDN09587.1 - 3e-05 22.6 1.4 3.8e-05 22.3 1.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EDN09587.1 - 5.3e-05 22.7 1.7 7e-05 22.3 1.7 1.3 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Aldolase_II PF00596.21 EDN09590.1 - 3.8e-12 46.5 0.1 4.8e-12 46.2 0.1 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CCDC66 PF15236.6 EDN09590.1 - 1.8 8.4 7.4 0.27 11.1 3.2 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 4HBT_3 PF13622.6 EDN09591.1 - 8.9e-78 262.0 0.7 1.1e-77 261.6 0.7 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EDN09591.1 - 1.7e-23 82.9 0.0 5.7e-12 45.6 0.0 3.4 3 1 0 3 3 3 3 Acyl-CoA thioesterase DUF4850 PF16142.5 EDN09592.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4850) DUF3328 PF11807.8 EDN09593.1 - 4e-22 79.1 0.0 4.8e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) UBA_3 PF09288.10 EDN09593.1 - 0.059 13.2 0.0 0.084 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain DUF3328 PF11807.8 EDN09595.1 - 9e-18 64.9 6.8 9.7e-18 64.8 6.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ank_2 PF12796.7 EDN09596.1 - 3.2e-31 107.8 0.6 2e-18 66.7 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN09596.1 - 3.3e-22 78.5 1.6 1.9e-08 34.7 0.0 3.8 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN09596.1 - 1.3e-19 69.9 0.1 2.7e-07 30.7 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN09596.1 - 4.9e-17 60.3 0.1 0.00068 19.9 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EDN09596.1 - 3.1e-16 59.0 0.1 0.00015 22.0 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat DUF3445 PF11927.8 EDN09597.1 - 3.3e-44 151.2 0.0 3.7e-44 151.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) INTS5_N PF14837.6 EDN09597.1 - 0.028 14.0 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus HSP70 PF00012.20 EDN09598.1 - 1.6e-06 26.7 0.1 4.4e-05 21.9 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EDN09598.1 - 0.19 10.5 0.0 0.34 9.7 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein N2227 PF07942.12 EDN09599.1 - 2.7e-89 299.0 0.0 3.4e-89 298.7 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EDN09599.1 - 0.028 14.3 0.0 0.07 13.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Myb_DNA-binding PF00249.31 EDN09600.1 - 0.0026 17.9 0.2 0.0054 16.9 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4244 PF14029.6 EDN09600.1 - 0.18 11.2 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) zf-C3HC4_2 PF13923.6 EDN09601.1 - 0.00013 21.8 1.7 0.00023 20.9 1.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN09601.1 - 0.00015 21.6 3.3 0.00025 20.8 3.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN09601.1 - 0.016 15.1 5.8 0.029 14.2 5.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DegS PF05384.11 EDN09601.1 - 0.022 14.2 0.2 0.033 13.7 0.2 1.2 1 0 0 1 1 1 0 Sensor protein DegS HAUS-augmin3 PF14932.6 EDN09601.1 - 0.024 14.2 0.1 0.033 13.8 0.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 zf-RING_UBOX PF13445.6 EDN09601.1 - 0.029 14.4 6.6 0.061 13.4 6.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Sec2p PF06428.11 EDN09601.1 - 0.095 12.7 0.4 0.14 12.1 0.4 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p CCDC158 PF15921.5 EDN09601.1 - 0.13 10.0 0.2 0.17 9.6 0.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 DUF5446 PF17522.2 EDN09601.1 - 0.14 12.4 0.4 0.2 11.8 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5446) zf-RING_2 PF13639.6 EDN09601.1 - 0.14 12.5 8.4 0.23 11.8 8.4 1.4 1 0 0 1 1 1 0 Ring finger domain Trimer_CC PF08954.11 EDN09601.1 - 0.18 11.4 3.7 0.62 9.7 3.6 1.9 1 1 0 1 1 1 0 Trimerisation motif SlyX PF04102.12 EDN09601.1 - 0.59 10.8 4.2 0.39 11.4 1.7 2.0 2 1 0 2 2 2 0 SlyX bZIP_2 PF07716.15 EDN09602.1 - 0.00058 19.9 7.1 0.001 19.1 7.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper DUF1235 PF06822.12 EDN09602.1 - 0.086 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) Noggin PF05806.12 EDN09602.1 - 0.12 12.3 1.1 1.8 8.4 0.0 2.1 2 0 0 2 2 2 0 Noggin TA_inhibitor PF17574.2 EDN09602.1 - 0.16 12.0 0.4 0.27 11.3 0.4 1.3 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) bZIP_1 PF00170.21 EDN09602.1 - 0.16 12.1 6.9 0.38 10.9 6.9 1.6 1 0 0 1 1 1 0 bZIP transcription factor OrfB_IS605 PF01385.19 EDN09602.1 - 0.22 11.7 4.1 0.26 11.5 2.8 1.7 2 0 0 2 2 2 0 Probable transposase DUF1635 PF07795.11 EDN09602.1 - 8 6.3 8.2 0.27 11.1 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) RasGEF PF00617.19 EDN09603.1 - 0.0079 16.4 0.0 0.048 13.9 0.0 2.3 1 1 1 2 2 2 1 RasGEF domain zf-C2H2_4 PF13894.6 EDN09605.1 - 0.028 15.2 1.4 6.4 7.9 0.5 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger IBR PF01485.21 EDN09605.1 - 0.3 11.3 2.9 1.1 9.5 2.9 2.0 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2_11 PF16622.5 EDN09605.1 - 0.34 10.7 3.4 0.55 10.0 0.7 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type RVT_1 PF00078.27 EDN09606.1 - 8.9e-40 136.5 0.0 1.6e-39 135.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN09606.1 - 3.5e-24 84.9 0.0 9.1e-24 83.6 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN09606.1 - 1e-13 51.7 0.0 3e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 RNase H Exo_endo_phos PF03372.23 EDN09606.1 - 2.3e-10 40.4 0.3 5.1e-10 39.3 0.3 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C2H2 PF00096.26 EDN09606.1 - 0.6 10.7 4.5 0.39 11.3 0.1 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN09606.1 - 1.3 10.0 5.6 0.52 11.3 0.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger Myb_DNA-binding PF00249.31 EDN09607.1 - 3.4e-11 43.1 4.5 2.1e-08 34.2 0.1 2.6 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN09607.1 - 2.3e-05 24.6 0.2 0.008 16.4 0.0 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Bac_DnaA PF00308.18 EDN09608.1 - 0.055 13.3 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein DUF3952 PF13130.6 EDN09608.1 - 0.1 12.8 0.7 0.23 11.6 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3952) SpecificRecomb PF10136.9 EDN09610.1 - 0.047 12.0 0.0 0.062 11.6 0.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase ExsD PF16806.5 EDN09610.1 - 0.088 12.7 0.3 0.13 12.2 0.3 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD APH PF01636.23 EDN09611.1 - 1.4e-06 28.4 0.7 8.8e-05 22.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 EDN09611.1 - 1.9e-05 24.2 0.0 2.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN09611.1 - 5.5e-05 22.6 0.1 9.7e-05 21.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AceK PF06315.11 EDN09611.1 - 0.00071 18.2 0.0 0.001 17.7 0.0 1.2 1 0 0 1 1 1 1 Isocitrate dehydrogenase kinase/phosphatase (AceK) Pkinase_Tyr PF07714.17 EDN09611.1 - 0.025 13.9 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Choline_kinase PF01633.20 EDN09611.1 - 0.052 13.1 0.0 0.17 11.4 0.0 1.8 1 1 0 2 2 2 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EDN09611.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF3435 PF11917.8 EDN09613.1 - 2.3e-144 481.4 2.7 4.5e-126 421.2 0.3 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EDN09613.1 - 1.6e-05 24.7 0.0 0.00035 20.4 0.0 2.4 1 1 0 1 1 1 1 Phage integrase family Abhydrolase_7 PF12715.7 EDN09614.1 - 0.16 11.2 0.8 0.17 11.1 0.8 1.0 1 0 0 1 1 1 0 Abhydrolase family Fungal_trans PF04082.18 EDN09615.1 - 3.6e-14 52.5 0.2 1.5e-13 50.4 0.2 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Prefoldin_2 PF01920.20 EDN09616.1 - 9.4e-19 67.3 4.2 1e-18 67.2 4.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit Rbsn PF11464.8 EDN09616.1 - 0.0099 15.6 1.1 0.025 14.3 1.1 1.8 1 0 0 1 1 1 1 Rabenosyn Rab binding domain Prefoldin PF02996.17 EDN09616.1 - 0.022 14.7 3.7 0.063 13.2 0.6 2.0 1 1 1 2 2 2 0 Prefoldin subunit DUF1664 PF07889.12 EDN09616.1 - 0.038 14.0 0.6 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4854 PF16146.5 EDN09616.1 - 0.062 13.6 0.5 0.072 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4854) Oxidored_nitro PF00148.19 EDN09616.1 - 0.13 11.0 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Seryl_tRNA_N PF02403.22 EDN09616.1 - 0.16 12.2 4.2 0.37 11.0 0.6 2.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain 60KD_IMP PF02096.20 EDN09616.1 - 0.22 11.4 0.1 0.61 10.0 0.0 1.6 2 0 0 2 2 2 0 60Kd inner membrane protein FlaC_arch PF05377.11 EDN09616.1 - 0.27 11.7 0.2 0.27 11.7 0.2 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FAM167 PF11652.8 EDN09616.1 - 0.5 10.9 3.2 6.6 7.3 0.4 2.2 1 1 0 2 2 2 0 FAM167 GPS2_interact PF15784.5 EDN09616.1 - 6.6 7.3 7.8 0.45 11.0 0.7 2.0 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain ATG27 PF09451.10 EDN09617.1 - 6.7e-94 314.6 0.0 7.9e-94 314.4 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EDN09617.1 - 6e-06 26.4 0.0 0.00021 21.4 0.0 2.2 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat Sulfotransfer_3 PF13469.6 EDN09618.1 - 2.4e-05 24.8 0.0 0.017 15.5 0.0 2.8 3 1 0 3 3 3 2 Sulfotransferase family Glyco_tranf_2_3 PF13641.6 EDN09619.1 - 5.8e-13 49.3 0.1 8.2e-13 48.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 SUZ PF12752.7 EDN09620.1 - 0.92 10.3 5.6 4.6 8.1 5.6 2.1 1 0 0 1 1 1 0 SUZ domain APH PF01636.23 EDN09621.1 - 2.8e-08 34.0 0.0 4.4e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN09621.1 - 0.002 17.8 0.1 0.0051 16.4 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 EDN09621.1 - 0.042 13.1 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 EDN09621.1 - 0.19 11.1 0.0 0.34 10.2 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain BCS1_N PF08740.11 EDN09624.1 - 3.6e-16 59.7 0.1 4.2e-16 59.5 0.1 1.1 1 0 0 1 1 1 1 BCS1 N terminal Elongin_A PF06881.11 EDN09624.1 - 0.078 13.5 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A bZIP_1 PF00170.21 EDN09625.1 - 5.8e-05 23.1 0.4 0.0001 22.3 0.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor DUF4699 PF15770.5 EDN09625.1 - 0.013 15.3 0.5 0.017 14.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) Paramyxo_P PF01806.17 EDN09625.1 - 0.013 14.9 0.4 0.024 14.1 0.0 1.6 2 0 0 2 2 2 0 Paramyxovirinae P phosphoprotein C-terminal region CASP_C PF08172.12 EDN09625.1 - 0.044 13.1 1.0 2.4 7.4 0.7 2.6 2 1 0 2 2 2 0 CASP C terminal bZIP_2 PF07716.15 EDN09625.1 - 0.048 13.8 0.8 0.092 12.8 0.8 1.4 1 0 0 1 1 1 0 Basic region leucine zipper HTH_8 PF02954.19 EDN09627.1 - 0.01 15.6 1.6 0.12 12.2 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory protein, Fis family HTH_Tnp_Tc5 PF03221.16 EDN09627.1 - 0.059 13.4 0.2 0.27 11.3 0.0 2.3 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF4322 PF14210.6 EDN09627.1 - 0.11 12.4 0.1 9.6 6.2 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4322) HTH_psq PF05225.16 EDN09627.1 - 0.11 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Mucin PF01456.17 EDN09630.1 - 0.071 13.1 13.4 0.17 11.8 13.4 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein CFEM PF05730.11 EDN09634.1 - 0.00044 20.3 4.5 0.00044 20.3 4.5 2.3 2 0 0 2 2 2 1 CFEM domain Sds3 PF08598.11 EDN09635.1 - 2.8e-50 171.3 1.1 1.4e-48 165.8 1.7 2.1 1 1 1 2 2 2 2 Sds3-like FAM184 PF15665.5 EDN09635.1 - 0.015 15.1 5.5 0.015 15.1 5.5 1.9 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Glyco_hydro_72 PF03198.14 EDN09637.1 - 1.5e-90 303.7 0.1 2.8e-90 302.8 0.1 1.4 1 1 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 EDN09637.1 - 0.18 10.8 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain RHH_7 PF16777.5 EDN09638.1 - 0.16 12.4 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator, RHH-like, CopG Aldose_epim PF01263.20 EDN09639.1 - 3.7e-40 138.1 0.6 6.2e-37 127.5 0.6 2.0 1 1 0 1 1 1 1 Aldose 1-epimerase DUF4661 PF15576.6 EDN09639.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Actin PF00022.19 EDN09640.1 - 4.9e-23 81.4 0.0 3.2e-20 72.1 0.0 3.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EDN09640.1 - 0.03 13.1 0.0 0.27 10.0 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein XPG_I PF00867.18 EDN09641.1 - 3.6e-23 81.7 0.0 9.5e-23 80.4 0.0 1.8 1 0 0 1 1 1 1 XPG I-region GEN1_C PF18380.1 EDN09641.1 - 7.4e-20 71.8 0.5 2.5e-19 70.1 0.0 2.2 2 0 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 EDN09641.1 - 0.00023 21.6 0.0 0.00059 20.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain GEMIN8 PF15348.6 EDN09641.1 - 2.4 8.4 6.5 15 5.8 0.6 2.4 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DEAD PF00270.29 EDN09642.1 - 1.9e-37 128.7 0.0 1.5e-36 125.8 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 EDN09642.1 - 8.3e-22 77.2 0.0 1.5e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 EDN09642.1 - 1.1e-19 70.8 0.0 2.8e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN09642.1 - 0.0035 17.4 0.1 0.015 15.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN09642.1 - 0.012 15.8 2.2 0.036 14.3 0.2 2.6 2 1 0 2 2 2 0 AAA domain DDE_Tnp_1_6 PF13751.6 EDN09643.1 - 0.4 10.9 2.0 0.84 9.9 2.0 1.5 1 0 0 1 1 1 0 Transposase DDE domain Ribosomal_S15 PF00312.22 EDN09645.1 - 2.8e-22 78.7 1.1 5.5e-22 77.8 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein S15 DUF5537 PF17690.1 EDN09645.1 - 0.015 15.0 0.3 0.03 14.0 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5537) PseudoU_synth_1 PF01416.20 EDN09646.1 - 6.9e-33 113.4 0.0 2e-32 111.8 0.0 1.8 2 0 0 2 2 2 1 tRNA pseudouridine synthase PIG-H PF10181.9 EDN09647.1 - 1.1e-26 92.5 0.6 1.8e-26 91.8 0.6 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component YukD PF08817.10 EDN09648.1 - 0.0089 16.7 0.0 0.016 15.9 0.0 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 EDN09648.1 - 0.018 14.7 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Pribosyl_synth PF14572.6 EDN09649.1 - 2.2e-42 145.2 1.3 3.4e-37 128.2 0.4 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDN09649.1 - 2.8e-35 120.7 0.0 8.2e-35 119.3 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDN09649.1 - 5.2e-13 48.8 0.5 1.5e-12 47.3 0.3 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDN09649.1 - 0.015 14.7 0.1 0.025 14.0 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase HSP70 PF00012.20 EDN09650.1 - 7.7e-22 77.2 6.1 8e-18 63.9 0.0 3.0 3 1 0 3 3 3 2 Hsp70 protein NPV_P10 PF05531.12 EDN09650.1 - 0.94 10.0 3.6 5.6 7.5 0.4 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1802 PF08819.11 EDN09651.1 - 0.0011 18.9 0.1 0.013 15.4 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1802) DUF2347 PF09804.9 EDN09652.1 - 2.9e-90 302.7 0.0 8.4e-90 301.2 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EDN09652.1 - 4.3e-40 138.0 0.0 5.9e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) Avl9 PF09794.9 EDN09652.1 - 3.4e-06 26.0 0.0 0.014 14.1 0.0 3.1 2 1 1 3 3 3 3 Transport protein Avl9 SPA PF08616.10 EDN09652.1 - 0.0081 16.1 0.0 0.02 14.8 0.0 1.6 1 1 0 1 1 1 1 Stabilization of polarity axis EBP PF05241.12 EDN09653.1 - 1.3e-59 200.7 9.1 1.4e-59 200.5 9.1 1.0 1 0 0 1 1 1 1 Emopamil binding protein YmcE_antitoxin PF15939.5 EDN09653.1 - 0.022 14.9 0.3 0.048 13.8 0.3 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system SNF2_N PF00176.23 EDN09656.1 - 7.2e-61 205.8 0.0 1.1e-60 205.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN09656.1 - 1.8e-14 54.0 0.0 5e-14 52.6 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN09656.1 - 3.5e-11 43.4 0.0 6.1e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDN09656.1 - 0.0014 17.8 0.0 0.0029 16.8 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EDN09656.1 - 0.0061 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase ClpB_D2-small PF10431.9 EDN09657.1 - 7e-26 90.1 0.6 1.8e-25 88.8 0.6 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_2 PF07724.14 EDN09657.1 - 4.5e-10 39.9 0.0 1.5e-09 38.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF1192 PF06698.11 EDN09657.1 - 0.0064 16.5 0.8 0.0064 16.5 0.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) DUF3375 PF11855.8 EDN09657.1 - 0.025 13.5 0.0 0.042 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) ABC_tran_CTD PF16326.5 EDN09657.1 - 0.091 13.0 2.8 0.32 11.3 0.1 2.9 3 0 0 3 3 3 0 ABC transporter C-terminal domain Matrilin_ccoil PF10393.9 EDN09657.1 - 0.24 11.3 4.5 0.7 9.8 0.4 2.8 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DDE_3 PF13358.6 EDN09658.1 - 2.3e-07 30.7 1.1 3.6e-07 30.0 1.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1_7 PF13843.6 EDN09660.1 - 2.1e-14 53.6 0.0 3.1e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 F-box PF00646.33 EDN09661.1 - 0.046 13.6 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 F-box domain Apolipoprotein PF01442.18 EDN09661.1 - 0.18 11.7 1.1 11 5.8 0.0 3.2 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain LMP PF04778.12 EDN09661.1 - 1.2 9.1 3.3 0.48 10.3 0.1 1.9 3 0 0 3 3 3 0 LMP repeated region Pkinase PF00069.25 EDN09665.1 - 1e-25 90.7 0.0 1.3e-25 90.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09665.1 - 3.6e-06 26.5 0.0 6e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDN09665.1 - 0.001 18.4 0.2 0.0016 17.9 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN09665.1 - 0.034 14.1 0.2 0.048 13.6 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN09665.1 - 0.11 11.2 0.2 0.16 10.7 0.2 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EDN09665.1 - 0.14 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Myb_DNA-binding PF00249.31 EDN09666.1 - 2.4e-05 24.4 0.0 4.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN09666.1 - 0.0016 18.7 0.0 0.0049 17.1 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Exo_endo_phos_2 PF14529.6 EDN09668.1 - 1.6e-13 50.5 0.0 3.9e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 EDN09668.1 - 2.2e-07 30.6 0.0 3.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 EDN09668.1 - 1.7e-05 24.5 0.0 3.4e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 EDN09669.1 - 0.048 13.2 0.0 0.056 12.9 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_1 PF03184.19 EDN09670.1 - 1.3e-21 77.0 0.2 6.5e-21 74.8 0.2 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN09670.1 - 0.035 14.1 0.0 0.079 13.0 0.0 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EDN09670.1 - 0.17 11.7 0.2 11 5.7 0.1 2.3 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_1 PF03184.19 EDN09671.1 - 1.5e-22 80.1 0.0 3.2e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN09671.1 - 0.0001 22.1 0.0 0.00075 19.3 0.0 2.4 1 1 1 2 2 2 1 DDE superfamily endonuclease Gastrin PF00918.17 EDN09671.1 - 0.98 10.4 6.1 3 8.8 6.1 1.8 1 0 0 1 1 1 0 Gastrin/cholecystokinin family XRN_M PF17846.1 EDN09671.1 - 3.4 6.5 6.3 5.7 5.8 6.3 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Macoilin PF09726.9 EDN09671.1 - 5.5 5.4 13.9 7.6 5.0 13.9 1.1 1 0 0 1 1 1 0 Macoilin family CPBP PF02517.16 EDN09672.1 - 1.7e-15 57.2 6.7 1.7e-15 57.2 6.7 1.7 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Suc_Fer-like PF06999.12 EDN09673.1 - 1.8e-49 168.3 0.0 2.1e-49 168.1 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like tRNA-synt_1 PF00133.22 EDN09674.1 - 5e-47 160.5 0.0 1.4e-34 119.3 0.0 5.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EDN09674.1 - 1.6e-39 135.4 0.0 2.3e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EDN09674.1 - 4.3e-26 91.6 5.4 1.4e-22 80.0 0.0 4.4 3 1 2 5 5 5 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDN09674.1 - 5.2e-14 52.5 0.0 1e-13 51.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EDN09674.1 - 0.038 13.3 0.0 0.076 12.3 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain zf-ribbon_3 PF13248.6 EDN09674.1 - 0.6 9.6 2.6 4.2 6.9 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Nexin_C PF08628.12 EDN09675.1 - 0.0037 17.8 0.6 0.0044 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal RVT_1 PF00078.27 EDN09676.1 - 2.4e-16 59.9 0.0 4.4e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN09676.1 - 6.7e-12 45.8 0.0 1.7e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN09676.1 - 0.053 13.9 0.5 0.17 12.3 0.5 1.8 1 0 0 1 1 1 0 ORF 12 gene product N-terminal DDE_1 PF03184.19 EDN09677.1 - 5.7e-20 71.7 0.0 1.2e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN09677.1 - 4.1e-14 52.4 0.8 8.8e-14 51.3 0.1 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN09677.1 - 0.0015 18.2 0.1 0.0035 17.0 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN09677.1 - 0.011 15.5 0.1 0.038 13.7 0.1 1.9 2 0 0 2 2 2 0 DDE superfamily endonuclease 2-Hacid_dh_C PF02826.19 EDN09678.1 - 8.5e-50 168.6 0.0 1.3e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN09678.1 - 8.6e-16 57.8 0.0 1.2e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDN09678.1 - 0.00045 20.4 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF756 PF05506.12 EDN09678.1 - 0.16 12.9 0.1 10 7.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF756) FH2 PF02181.23 EDN09681.1 - 4.1e-85 286.1 2.5 4.1e-85 286.1 2.5 2.0 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EDN09681.1 - 2.5e-71 239.1 0.0 6.5e-71 237.8 0.0 1.7 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EDN09681.1 - 2.6e-51 174.0 5.2 6.1e-51 172.8 1.2 2.8 2 1 1 3 3 3 1 Diaphanous FH3 Domain TC1 PF15063.6 EDN09681.1 - 0.0075 16.1 0.5 0.37 10.7 0.0 2.9 2 0 0 2 2 2 1 Thyroid cancer protein 1 Nterm_IS4 PF13006.7 EDN09681.1 - 0.14 12.3 0.0 0.54 10.5 0.0 2.0 1 0 0 1 1 1 0 Insertion element 4 transposase N-terminal DUF4744 PF15918.5 EDN09681.1 - 0.36 11.7 4.9 1.5 9.7 4.9 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) TrmE_N PF10396.9 EDN09684.1 - 3.8e-37 127.1 0.0 1.5e-36 125.2 0.0 2.0 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 EDN09684.1 - 6.3e-31 108.2 0.0 1.6e-30 106.9 0.0 1.7 1 1 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EDN09684.1 - 2.9e-18 66.0 0.0 5.6e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDN09684.1 - 5.5e-05 23.3 0.0 0.0001 22.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GTP_EFTU PF00009.27 EDN09684.1 - 0.00021 20.9 0.1 0.018 14.6 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EDN09684.1 - 0.00025 20.6 0.0 0.0011 18.6 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B F-box PF00646.33 EDN09684.1 - 0.00061 19.6 0.1 0.0023 17.8 0.1 2.1 1 0 0 1 1 1 1 F-box domain ABC_tran PF00005.27 EDN09684.1 - 0.11 13.0 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EDN09684.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain zf-C2H2_6 PF13912.6 EDN09685.1 - 3.1e-06 27.0 8.8 0.031 14.3 1.9 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDN09685.1 - 0.004 17.9 23.4 0.9 10.5 1.5 5.2 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2HE PF16278.5 EDN09685.1 - 0.031 14.7 6.9 15 6.1 0.0 3.2 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 EDN09685.1 - 0.031 14.7 27.2 2 9.0 2.8 5.2 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EDN09685.1 - 0.097 13.0 15.6 0.69 10.3 0.4 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF4690 PF15756.5 EDN09686.1 - 0.011 16.3 0.2 0.042 14.5 0.0 2.0 2 0 0 2 2 2 0 Small Novel Rich in Cartilage CD99L2 PF12301.8 EDN09686.1 - 0.13 12.5 0.1 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 CD99 antigen like protein 2 Aconitase PF00330.20 EDN09687.1 - 1.6e-112 376.9 0.1 1.5e-111 373.7 0.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDN09687.1 - 8.3e-24 84.4 0.0 1.6e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF5068 PF16781.5 EDN09687.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5068) MCM PF00493.23 EDN09687.1 - 0.15 11.1 0.1 0.29 10.2 0.1 1.4 1 0 0 1 1 1 0 MCM P-loop domain Aminotran_5 PF00266.19 EDN09689.1 - 1e-26 93.8 0.0 1.8e-19 69.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V NAD_binding_1 PF00175.21 EDN09690.1 - 8.7e-06 26.3 0.0 8.3e-05 23.2 0.0 2.2 1 1 1 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EDN09690.1 - 0.0063 16.6 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 EDN09690.1 - 0.017 15.4 0.0 0.079 13.3 0.0 1.9 1 1 1 2 2 2 0 Oxidoreductase FAD-binding domain AA_permease_2 PF13520.6 EDN09691.1 - 3e-59 201.0 36.3 4e-59 200.5 36.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDN09691.1 - 2.6e-23 82.4 21.3 2.6e-23 82.4 21.3 2.0 2 0 0 2 2 2 1 Amino acid permease PrmC_N PF17827.1 EDN09692.1 - 2e-07 31.5 0.5 1.2e-06 29.0 0.2 2.5 2 1 0 2 2 2 1 PrmC N-terminal domain Methyltransf_31 PF13847.6 EDN09692.1 - 1.1e-05 25.3 0.0 1.7e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN09692.1 - 6.6e-05 23.5 0.0 0.00026 21.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDN09692.1 - 7.8e-05 22.3 0.0 0.00028 20.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EDN09692.1 - 0.019 15.7 0.0 0.077 13.7 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Menin PF05053.13 EDN09692.1 - 0.13 10.6 0.6 0.18 10.1 0.6 1.2 1 0 0 1 1 1 0 Menin Asp PF00026.23 EDN09693.1 - 2.1e-61 208.1 0.0 2.1e-49 168.7 0.0 2.3 2 1 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDN09693.1 - 4.5e-08 33.5 2.0 4.3e-06 27.1 1.0 3.5 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDN09693.1 - 0.0033 18.0 0.1 7.7 7.2 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EDN09693.1 - 0.018 14.8 0.0 0.041 13.7 0.0 1.6 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Rep_fac_C PF08542.11 EDN09694.1 - 1.3e-24 86.4 0.0 3.3e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EDN09694.1 - 3.7e-12 46.3 0.0 1.2e-08 34.9 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EDN09694.1 - 4.9e-11 43.2 0.0 7.9e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EDN09694.1 - 1.6e-06 28.2 0.0 4.8e-06 26.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDN09694.1 - 1.5e-05 25.5 0.0 0.0011 19.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDN09694.1 - 1.6e-05 24.7 0.0 3.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 EDN09694.1 - 1.8e-05 24.6 0.0 2.8e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 EDN09694.1 - 0.00022 21.1 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EDN09694.1 - 0.00033 20.5 0.1 0.00049 19.9 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EDN09694.1 - 0.00033 21.0 0.1 0.55 10.5 0.1 2.5 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 EDN09694.1 - 0.0016 18.4 0.0 0.0034 17.3 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EDN09694.1 - 0.0046 16.4 0.1 0.053 12.9 0.0 2.2 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 EDN09694.1 - 0.0046 17.3 0.0 0.013 15.8 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain MeaB PF03308.16 EDN09694.1 - 0.0057 15.7 0.0 0.0098 14.9 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_11 PF13086.6 EDN09694.1 - 0.0063 16.3 0.0 0.0084 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EDN09694.1 - 0.0072 15.7 0.0 2.3 7.6 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein AAA_19 PF13245.6 EDN09694.1 - 0.0092 16.3 0.1 0.021 15.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 EDN09694.1 - 0.012 15.4 0.1 0.72 9.6 0.0 2.4 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_24 PF13479.6 EDN09694.1 - 0.025 14.3 0.0 0.084 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 EDN09694.1 - 0.035 13.6 0.0 0.058 12.8 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_30 PF13604.6 EDN09694.1 - 0.036 13.8 0.1 0.097 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDN09694.1 - 0.047 13.6 0.2 0.13 12.1 0.1 1.8 1 1 1 2 2 2 0 NTPase AAA_25 PF13481.6 EDN09694.1 - 0.079 12.5 0.0 0.38 10.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain FAD_binding_3 PF01494.19 EDN09695.1 - 2.3e-12 46.9 0.5 2.3e-08 33.7 0.0 2.8 3 0 0 3 3 3 2 FAD binding domain Trp_halogenase PF04820.14 EDN09695.1 - 6e-09 35.3 3.0 0.00031 19.7 0.3 2.1 1 1 1 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 EDN09695.1 - 5.7e-06 25.6 0.0 9.7e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EDN09695.1 - 1.2e-05 25.1 6.1 0.04 13.5 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN09695.1 - 0.0002 20.7 0.2 0.017 14.4 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN09695.1 - 0.00028 21.0 1.6 0.00084 19.5 1.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EDN09695.1 - 0.00063 19.2 0.1 0.00091 18.7 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDN09695.1 - 0.0011 18.1 7.4 0.0088 15.2 6.7 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EDN09695.1 - 0.0039 15.9 2.5 0.013 14.3 2.2 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EDN09695.1 - 0.042 13.1 0.3 0.069 12.4 0.3 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Tfb2_C PF18307.1 EDN09695.1 - 0.18 12.3 0.0 0.63 10.5 0.0 1.9 2 0 0 2 2 2 0 Transcription factor Tfb2 (p52) C-terminal domain 3HCDH_N PF02737.18 EDN09695.1 - 0.22 11.4 2.9 0.35 10.7 2.9 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDN09695.1 - 0.34 10.2 1.2 0.68 9.2 1.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EDN09695.1 - 0.62 9.1 6.1 1.1 8.3 6.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 EDN09695.1 - 1.3 9.6 5.4 2.8 8.6 3.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_deac_1 PF01522.21 EDN09696.1 - 6.9e-19 68.0 0.0 1.4e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EDN09696.1 - 1.4e-05 24.8 0.0 4.2e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) adh_short PF00106.25 EDN09697.1 - 2.3e-36 125.1 0.2 3e-36 124.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN09697.1 - 1.6e-35 122.8 0.2 2e-35 122.5 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN09697.1 - 1.1e-05 25.4 1.1 0.00011 22.2 1.1 2.1 1 1 0 1 1 1 1 KR domain Amidase PF01425.21 EDN09698.1 - 9.2e-100 334.7 0.0 1.2e-99 334.3 0.0 1.1 1 0 0 1 1 1 1 Amidase FAD_binding_3 PF01494.19 EDN09699.1 - 8.7e-64 216.0 2.0 1.3e-61 208.8 2.0 2.1 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EDN09699.1 - 1.3e-26 93.6 0.0 2.3e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain HI0933_like PF03486.14 EDN09699.1 - 0.21 10.3 0.1 0.35 9.5 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Ald_Xan_dh_C2 PF02738.18 EDN09700.1 - 1.1e-198 661.2 0.1 1.5e-198 660.8 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EDN09700.1 - 3.5e-38 131.0 0.0 7.5e-38 129.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EDN09700.1 - 3.3e-35 120.4 0.0 2.1e-34 117.7 0.0 2.4 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 EDN09700.1 - 6.9e-27 94.0 0.0 1.6e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 EDN09700.1 - 3.4e-25 87.9 0.0 8.2e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EDN09700.1 - 1.8e-08 34.2 0.2 1.6e-07 31.2 0.0 2.6 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fungal_trans PF04082.18 EDN09701.1 - 6.5e-28 97.5 2.8 9e-28 97.0 2.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EDN09702.1 - 1.4e-07 31.5 12.0 0.0024 18.2 0.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN09702.1 - 3e-05 24.5 9.6 0.032 15.1 0.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EDN09702.1 - 0.038 14.6 1.8 0.083 13.5 1.8 1.6 1 0 0 1 1 1 0 FOXP coiled-coil domain zf-met PF12874.7 EDN09702.1 - 0.041 14.3 0.1 11 6.6 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ApoA-II PF04711.13 EDN09703.1 - 0.16 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) DDE_Tnp_1_7 PF13843.6 EDN09704.1 - 1.2e-15 57.7 0.0 7.5e-13 48.5 0.0 2.1 1 1 1 2 2 2 2 Transposase IS4 Nexin_C PF08628.12 EDN09704.1 - 0.032 14.8 0.4 0.059 13.9 0.4 1.3 1 0 0 1 1 1 0 Sorting nexin C terminal RVT_1 PF00078.27 EDN09705.1 - 1.3e-23 83.7 0.0 2.3e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN09705.1 - 7.4e-12 45.6 0.0 1.7e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN09705.1 - 0.046 14.1 0.5 0.16 12.4 0.5 1.9 1 0 0 1 1 1 0 ORF 12 gene product N-terminal RVT_3 PF13456.6 EDN09705.1 - 0.13 12.0 0.4 1.3 8.9 0.1 2.5 2 1 0 2 2 2 0 Reverse transcriptase-like Macoilin PF09726.9 EDN09706.1 - 0.025 13.2 4.7 0.031 12.9 4.7 1.2 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 EDN09706.1 - 3 6.9 26.7 3.8 6.6 26.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF410 PF04190.13 EDN09707.1 - 2.3e-53 181.6 0.0 3e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Clathrin_H_link PF13838.6 EDN09707.1 - 0.12 12.3 0.4 0.23 11.4 0.4 1.5 1 0 0 1 1 1 0 Clathrin-H-link RAI1 PF08652.11 EDN09708.1 - 4.8e-29 100.4 0.0 1e-28 99.3 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease IPPT PF01715.17 EDN09709.1 - 1.9e-07 31.1 0.0 3.7e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 IPP transferase ABC_tran PF00005.27 EDN09710.1 - 2.8e-17 63.5 0.1 2.9e-16 60.2 0.1 2.1 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDN09710.1 - 6.2e-11 42.6 4.2 8.8e-05 22.4 0.2 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDN09710.1 - 4.7e-05 22.9 0.1 0.082 12.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN09710.1 - 8.1e-05 22.3 0.2 0.00026 20.7 0.2 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EDN09710.1 - 0.0034 17.9 0.0 0.005 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDN09710.1 - 0.0096 15.8 0.1 0.015 15.2 0.1 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 EDN09710.1 - 0.017 14.8 0.1 0.024 14.4 0.1 1.1 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EDN09710.1 - 0.019 15.0 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 EDN09710.1 - 0.02 14.5 0.1 0.045 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 EDN09710.1 - 0.054 13.1 0.0 0.084 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EDN09710.1 - 0.058 13.1 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 EDN09710.1 - 0.062 13.7 1.1 0.15 12.4 1.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EDN09710.1 - 0.074 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_28 PF13521.6 EDN09710.1 - 0.12 12.6 0.3 0.24 11.7 0.3 1.5 1 0 0 1 1 1 0 AAA domain DLIC PF05783.11 EDN09710.1 - 0.15 10.8 0.1 0.25 10.1 0.1 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Dynamin_N PF00350.23 EDN09710.1 - 0.18 11.9 0.1 0.29 11.2 0.1 1.2 1 0 0 1 1 1 0 Dynamin family DUF3584 PF12128.8 EDN09710.1 - 0.29 8.6 0.0 0.38 8.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) WD40 PF00400.32 EDN09712.1 - 1.3e-19 70.2 21.0 0.00022 22.0 0.2 7.4 8 0 0 8 8 8 5 WD domain, G-beta repeat Urm1 PF09138.11 EDN09713.1 - 7.9e-34 115.9 0.0 9.3e-34 115.7 0.0 1.1 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EDN09713.1 - 0.00047 20.7 0.0 0.00073 20.1 0.0 1.3 1 0 0 1 1 1 1 ThiS family DUF4916 PF16262.5 EDN09713.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4916) 6PF2K PF01591.18 EDN09714.1 - 1.6e-62 210.7 0.0 2.1e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDN09714.1 - 7.9e-11 42.0 0.2 3.9e-05 23.4 0.0 3.1 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDN09714.1 - 0.065 13.4 0.0 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 EDN09714.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Porin_3 PF01459.22 EDN09715.1 - 7.4e-84 281.4 0.8 8.6e-84 281.2 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic porin Zds_C PF08632.10 EDN09715.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term MIF4G_like_2 PF09090.11 EDN09718.1 - 1.3e-66 224.9 0.0 2.5e-66 223.9 0.0 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.11 EDN09718.1 - 3.7e-65 219.3 0.2 7e-63 211.9 0.2 2.3 1 1 0 1 1 1 1 MIF4G like FA_hydroxylase PF04116.13 EDN09721.1 - 1.4e-07 32.0 0.3 1.4e-07 32.0 0.3 2.1 1 1 1 2 2 2 2 Fatty acid hydroxylase superfamily WD40 PF00400.32 EDN09722.1 - 1.3e-60 199.9 15.4 1.2e-09 38.6 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EDN09722.1 - 2.3e-18 66.3 11.1 3.9e-18 65.5 11.1 1.4 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EDN09722.1 - 1.6e-17 63.5 0.0 0.00011 22.4 0.0 6.5 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDN09722.1 - 1.2e-07 31.4 0.0 0.061 12.6 0.0 4.7 3 1 2 5 5 5 3 WD40-like domain Cytochrom_D1 PF02239.16 EDN09722.1 - 1.1e-06 27.5 0.7 0.00032 19.3 0.1 3.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EDN09722.1 - 1.5e-05 24.2 0.1 0.37 9.7 0.0 4.6 1 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDN09722.1 - 0.00065 19.6 0.0 0.092 12.6 0.0 3.0 1 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDN09722.1 - 0.0019 16.9 0.2 0.49 9.0 0.0 3.1 2 1 1 3 3 3 1 Nucleoporin Nup120/160 PD40 PF07676.12 EDN09722.1 - 0.0058 16.5 0.0 19 5.3 0.0 4.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat MMS1_N PF10433.9 EDN09722.1 - 0.034 12.8 0.0 5.4 5.5 0.0 2.2 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Nucleoporin_N PF08801.11 EDN09722.1 - 0.066 11.9 0.0 17 4.0 0.0 3.5 2 1 1 3 3 3 0 Nup133 N terminal like VID27 PF08553.10 EDN09722.1 - 0.16 11.0 0.1 4.8 6.1 0.1 2.9 2 1 2 4 4 4 0 VID27 C-terminal WD40-like domain Nbas_N PF15492.6 EDN09722.1 - 0.17 11.2 0.0 10 5.4 0.0 2.5 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal TPX2 PF06886.11 EDN09722.1 - 0.34 11.2 8.5 0.6 10.4 8.5 1.4 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) UPF0242 PF06785.11 EDN09722.1 - 1.9 8.6 7.4 2.8 8.0 7.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2 PF00096.26 EDN09724.1 - 2.6e-15 55.9 27.9 0.00014 22.1 0.9 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN09724.1 - 5.3e-14 51.9 28.4 2.1e-07 31.0 3.0 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN09724.1 - 1.8e-08 34.5 23.7 0.11 13.4 0.8 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EDN09724.1 - 0.0039 17.4 2.3 0.13 12.4 0.2 2.6 2 1 0 2 2 2 1 Aberrant zinc-finger zf-C2H2_8 PF15909.5 EDN09724.1 - 0.0077 16.5 7.4 0.052 13.8 4.6 2.7 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-met PF12874.7 EDN09724.1 - 0.013 15.8 10.0 0.11 13.0 0.4 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-LYAR PF08790.11 EDN09724.1 - 1.4 8.9 7.4 9.4 6.2 0.4 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Mito_carr PF00153.27 EDN09725.1 - 3.6e-61 203.1 2.1 5.5e-21 74.3 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 EDN09726.1 - 9.5e-35 118.3 0.0 1.1e-16 60.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN09726.1 - 0.0019 17.8 0.0 0.091 12.4 0.0 2.4 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN09726.1 - 0.0027 17.8 0.0 0.034 14.3 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif Cas_Cas2CT1978 PF09707.10 EDN09726.1 - 0.05 13.7 0.0 10 6.2 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Limkain-b1 PF11608.8 EDN09726.1 - 0.061 13.4 0.2 2.2 8.4 0.1 2.2 2 0 0 2 2 2 0 Limkain b1 OB_RNB PF08206.11 EDN09726.1 - 0.095 12.4 0.3 9.1 6.0 0.1 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF2015 PF09435.10 EDN09727.1 - 7.1e-46 154.7 0.0 8.1e-46 154.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Vps55 PF04133.14 EDN09727.1 - 0.072 13.1 0.0 0.084 12.8 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 55 Ribosomal_L28e PF01778.17 EDN09728.1 - 2.8e-33 115.1 0.5 4.3e-33 114.5 0.5 1.3 1 0 0 1 1 1 1 Ribosomal L28e protein family Nexin_C PF08628.12 EDN09729.1 - 0.014 16.0 0.2 0.023 15.2 0.2 1.3 1 0 0 1 1 1 0 Sorting nexin C terminal SecD_SecF PF02355.16 EDN09729.1 - 0.11 11.9 0.2 0.15 11.4 0.2 1.1 1 0 0 1 1 1 0 Protein export membrane protein TEX13 PF15186.6 EDN09730.1 - 0.0055 16.4 0.1 0.0057 16.4 0.1 1.1 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family Glyco_hydro_35 PF01301.19 EDN09732.1 - 0.026 14.1 0.1 0.027 14.1 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 HTH_Tnp_Tc3_2 PF01498.18 EDN09733.1 - 2.1e-25 88.7 0.0 3.3e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EDN09733.1 - 0.00019 22.0 0.2 0.00057 20.5 0.0 1.9 3 0 0 3 3 3 1 Homeodomain-like domain HTH_33 PF13592.6 EDN09733.1 - 0.0036 16.9 0.0 0.0065 16.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_21 PF13276.6 EDN09733.1 - 0.0048 17.0 0.0 0.0079 16.3 0.0 1.3 1 0 0 1 1 1 1 HTH-like domain HTH_23 PF13384.6 EDN09733.1 - 0.04 13.7 0.0 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain Ldh_1_N PF00056.23 EDN09734.1 - 1.3e-45 154.9 0.1 1.9e-45 154.4 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EDN09734.1 - 2.6e-40 138.1 0.0 3.7e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EDN09734.1 - 2.4e-06 26.8 0.0 3.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDN09734.1 - 0.00023 21.1 0.0 0.00065 19.6 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 EDN09734.1 - 0.012 14.9 0.1 0.096 12.0 0.0 2.4 2 2 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.16 EDN09734.1 - 0.013 15.1 0.1 2.2 7.8 0.0 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase TRAPP PF04051.16 EDN09735.1 - 5.6e-10 39.1 0.0 6.3e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PorB PF11565.8 EDN09735.1 - 0.05 14.0 0.0 0.055 13.9 0.0 1.2 1 0 0 1 1 1 0 Alpha helical Porin B DUF2378 PF09536.10 EDN09735.1 - 0.091 12.6 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) PINIT PF14324.6 EDN09736.1 - 1.8e-40 138.6 0.1 3.5e-40 137.7 0.1 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EDN09736.1 - 1.1e-21 76.3 6.3 1.8e-21 75.6 6.3 1.3 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EDN09736.1 - 9.8e-08 31.7 1.9 2.1e-07 30.6 1.9 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EDN09736.1 - 2.8e-07 30.1 1.2 4.4e-07 29.5 0.1 2.0 2 0 0 2 2 2 1 SAP domain zf-Sec23_Sec24 PF04810.15 EDN09736.1 - 0.045 13.8 2.2 0.11 12.6 2.2 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Prok-RING_4 PF14447.6 EDN09736.1 - 0.25 11.2 3.3 0.52 10.2 3.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DAG1 PF05454.11 EDN09736.1 - 1.6 8.0 11.2 0.1 11.9 0.7 2.7 2 1 1 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF2423 PF10338.9 EDN09737.1 - 2.4e-19 69.3 1.9 2.4e-19 69.3 1.9 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2423) Phosphodiest PF01663.22 EDN09738.1 - 4.8e-12 46.1 1.6 1.4e-08 34.8 0.2 2.3 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDN09738.1 - 5.1e-05 22.8 0.0 0.00021 20.8 0.0 1.8 2 0 0 2 2 2 1 Sulfatase S_4TM PF18159.1 EDN09738.1 - 2.3 7.4 5.0 11 5.2 0.1 3.5 4 0 0 4 4 4 0 SMODS-associating 4TM effector domain tRNA-synt_1b PF00579.25 EDN09739.1 - 4.6e-57 193.6 0.0 5.5e-56 190.0 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.22 EDN09740.1 - 1.4e-26 92.5 0.0 2.3e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PNP_UDP_1 PF01048.20 EDN09741.1 - 2.7e-47 161.0 0.2 3.8e-47 160.5 0.2 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily Fcf2 PF08698.11 EDN09742.1 - 7e-37 125.7 0.5 1.7e-36 124.5 0.1 1.8 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing CBFD_NFYB_HMF PF00808.23 EDN09743.1 - 8.6e-19 67.6 0.6 1.3e-18 67.1 0.6 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDN09743.1 - 6.5e-16 58.9 0.2 1.2e-15 58.1 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EDN09743.1 - 0.059 13.7 0.0 0.097 13.0 0.0 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Pol_alpha_B_N PF08418.10 EDN09743.1 - 0.16 12.0 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Sec15 PF04091.12 EDN09744.1 - 2e-112 375.7 0.2 4.9e-112 374.4 0.2 1.7 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like COG7 PF10191.9 EDN09744.1 - 0.00014 20.3 4.8 0.035 12.4 0.0 2.4 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) Vps54_N PF10475.9 EDN09744.1 - 0.0051 16.1 5.5 0.012 14.9 5.5 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 EDN09744.1 - 0.0088 16.2 6.7 0.032 14.4 4.3 2.9 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.14 EDN09744.1 - 0.011 15.7 4.5 0.026 14.4 3.2 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Sec5 PF15469.6 EDN09744.1 - 0.012 15.5 4.8 0.074 12.8 1.9 2.9 3 0 0 3 3 3 0 Exocyst complex component Sec5 COG2 PF06148.11 EDN09744.1 - 0.034 14.2 8.8 0.023 14.8 5.5 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF16 PF01519.16 EDN09744.1 - 0.72 10.4 3.2 6.3 7.4 1.3 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 RRM_2 PF04059.12 EDN09745.1 - 3.9e-27 94.3 1.2 9.8e-27 93.0 1.2 1.7 1 1 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EDN09745.1 - 9.7e-10 38.1 0.1 0.028 14.2 0.0 4.0 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4840 PF16128.5 EDN09745.1 - 0.081 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4840) GTP_CH_N PF12471.8 EDN09746.1 - 1.1e-93 312.4 0.0 2.3e-93 311.3 0.0 1.5 2 0 0 2 2 2 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EDN09746.1 - 2e-15 56.8 0.0 3e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II Ribosomal_S3Ae PF01015.18 EDN09747.1 - 1.1e-84 283.1 2.5 1.3e-84 282.8 2.5 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 EDN09747.1 - 0.015 15.9 0.2 0.08 13.5 0.0 2.1 2 0 0 2 2 2 0 Translation initiation factor SUI1 CDT1 PF08839.11 EDN09747.1 - 0.026 14.8 0.5 0.052 13.8 0.1 1.7 2 0 0 2 2 2 0 DNA replication factor CDT1 like Shugoshin_N PF07558.11 EDN09747.1 - 0.032 14.1 0.7 4.1 7.3 0.9 2.7 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region NEMO PF11577.8 EDN09747.1 - 0.091 12.8 0.4 0.84 9.7 0.0 2.4 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Abhydro_lipase PF04083.16 EDN09747.1 - 0.16 11.5 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDN09748.1 - 4.6e-15 56.0 0.0 2.3e-13 50.4 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN09748.1 - 6.2e-07 28.9 0.0 1.3e-06 27.9 0.0 1.6 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDN09748.1 - 4.7e-06 27.4 0.0 5.6e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EDN09748.1 - 0.0067 16.1 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 EDN09748.1 - 0.018 14.0 0.0 0.049 12.5 0.0 1.7 2 0 0 2 2 2 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 EDN09748.1 - 0.034 13.2 0.0 0.075 12.0 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase Fib_alpha PF08702.10 EDN09748.1 - 0.047 13.9 0.1 0.066 13.4 0.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Thioesterase PF00975.20 EDN09748.1 - 0.049 13.7 0.0 0.061 13.4 0.0 1.3 1 1 0 1 1 1 0 Thioesterase domain Ndr PF03096.14 EDN09748.1 - 0.059 12.1 0.0 0.12 11.0 0.0 1.7 1 1 0 1 1 1 0 Ndr family BAAT_C PF08840.11 EDN09748.1 - 0.079 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.13 EDN09748.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.5 1 1 0 1 1 1 0 Serine hydrolase Ribonuclease_3 PF00636.26 EDN09749.1 - 3.6e-14 53.2 0.1 1.2e-13 51.5 0.0 2.0 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDN09749.1 - 6.7e-11 42.4 0.0 1.4e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like MRP-S33 PF08293.11 EDN09750.1 - 3.1e-28 97.8 0.1 3.7e-28 97.6 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 MutL_C PF08676.11 EDN09750.1 - 0.028 14.2 0.0 0.033 14.0 0.0 1.2 1 0 0 1 1 1 0 MutL C terminal dimerisation domain DUF382 PF04037.13 EDN09751.1 - 1.3e-59 199.9 1.4 2.9e-59 198.8 1.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EDN09751.1 - 1.5e-20 72.7 3.8 3.9e-20 71.5 3.8 1.8 1 0 0 1 1 1 1 PSP ER_lumen_recept PF00810.18 EDN09754.1 - 6.2e-36 124.4 0.2 9.5e-36 123.8 0.2 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Integrase_H2C2 PF17921.1 EDN09755.1 - 1.3e-07 31.6 0.8 1.3e-07 31.6 0.8 2.4 3 0 0 3 3 3 1 Integrase zinc binding domain Nucleo_P87 PF07267.11 EDN09757.1 - 0.85 8.4 6.5 0.39 9.5 4.1 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 HTH_7 PF02796.15 EDN09758.1 - 0.0044 17.1 0.0 0.012 15.6 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 EDN09758.1 - 0.036 13.8 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain XRCC4 PF06632.12 EDN09761.1 - 0.0021 17.0 16.9 0.0021 17.0 16.9 2.3 2 1 0 2 2 2 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 PBP1_TM PF14812.6 EDN09761.1 - 0.67 10.4 0.0 0.67 10.4 0.0 3.0 3 1 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EDN09761.1 - 8.2 5.6 9.6 15 4.8 9.6 1.4 1 0 0 1 1 1 0 NOA36 protein Molybdopterin PF00384.22 EDN09762.1 - 1.5e-71 241.6 0.0 3.4e-69 233.9 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 EDN09762.1 - 1.9e-17 63.7 0.1 4.3e-17 62.5 0.1 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EDN09762.1 - 2.8e-17 61.9 0.2 2.8e-17 61.9 0.2 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.6 EDN09762.1 - 1.7e-09 37.6 0.1 1.1e-06 28.6 0.0 3.1 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.27 EDN09762.1 - 0.14 12.0 1.1 3.5 7.6 0.3 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 EDN09762.1 - 0.68 10.1 3.0 0.54 10.4 1.0 1.9 2 0 0 2 2 2 0 4Fe-4S binding domain TPT PF03151.16 EDN09763.1 - 1.5e-07 31.1 1.2 2.3e-07 30.4 1.2 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family Peptidase_S9 PF00326.21 EDN09764.1 - 6.5e-08 32.3 0.2 1.2e-07 31.5 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EDN09764.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PUF PF00806.19 EDN09765.1 - 9e-35 116.4 2.9 1.1e-05 24.9 0.0 9.1 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat RraB PF06877.11 EDN09765.1 - 0.051 14.3 0.1 0.29 11.9 0.0 2.2 2 0 0 2 2 2 0 Regulator of ribonuclease activity B Miff PF05644.11 EDN09765.1 - 0.15 11.7 4.7 0.26 10.9 4.7 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Ssl1 PF04056.14 EDN09767.1 - 1.2e-72 243.8 0.0 1.9e-71 239.9 0.0 2.1 1 1 1 2 2 2 1 Ssl1-like C1_4 PF07975.12 EDN09767.1 - 3.7e-17 62.3 7.8 3.7e-17 62.3 7.8 2.2 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EDN09767.1 - 1.1e-16 61.4 0.0 2.2e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EDN09767.1 - 7.3e-05 23.1 0.0 0.00011 22.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain YL1 PF05764.13 EDN09767.1 - 0.16 12.0 4.0 0.22 11.6 4.0 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Peptidase_M1 PF01433.20 EDN09768.1 - 4.3e-82 274.9 2.8 4.3e-82 274.9 2.8 1.6 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 EDN09768.1 - 3.8e-67 227.1 0.1 2.9e-61 207.8 0.0 2.9 4 0 0 4 4 4 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EDN09768.1 - 3.2e-43 148.1 0.0 6.6e-43 147.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain SQHop_cyclase_C PF13243.6 EDN09769.1 - 2.5e-106 355.4 3.7 3e-98 328.9 1.0 3.2 3 0 0 3 3 3 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EDN09769.1 - 2.2e-101 338.8 0.3 3.2e-95 318.6 0.0 3.8 3 1 0 3 3 3 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EDN09769.1 - 1.7e-22 78.8 24.2 2.4e-05 24.0 0.3 6.6 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EDN09769.1 - 8.6e-07 28.3 1.8 0.057 12.4 0.0 4.6 5 0 0 5 5 5 2 A-macroglobulin TED domain Pec_lyase PF09492.10 EDN09769.1 - 0.00018 20.9 0.1 16 4.7 0.0 4.8 5 0 0 5 5 5 2 Pectic acid lyase p450 PF00067.22 EDN09770.1 - 1.2e-27 96.8 0.0 1.7e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EDN09771.1 - 2.7e-26 92.4 0.0 3.5e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF2781 PF10914.8 EDN09772.1 - 1.9e-30 106.2 11.7 2.2e-30 106.0 11.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Ras PF00071.22 EDN09774.1 - 1.2e-65 220.1 0.4 1.4e-65 219.8 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN09774.1 - 7.5e-36 123.0 0.1 1.3e-35 122.2 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN09774.1 - 1.4e-16 60.4 0.1 1.5e-16 60.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDN09774.1 - 1.8e-05 24.7 0.3 0.1 12.5 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDN09774.1 - 2.9e-05 24.1 0.0 9.8e-05 22.4 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDN09774.1 - 0.00015 21.4 0.3 0.00041 19.9 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN09774.1 - 0.00023 20.6 0.0 0.00029 20.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.29 EDN09774.1 - 0.00043 20.7 0.1 0.24 11.8 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EDN09774.1 - 0.00077 18.9 0.0 0.00098 18.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDN09774.1 - 0.0044 16.6 0.0 0.027 14.0 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EDN09774.1 - 0.0078 16.6 0.0 0.01 16.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Septin PF00735.18 EDN09774.1 - 0.035 13.4 0.1 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 EDN09774.1 - 0.036 13.6 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 EDN09774.1 - 0.039 14.2 0.0 0.069 13.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDN09774.1 - 0.058 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDN09774.1 - 0.072 13.6 0.0 0.15 12.6 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 EDN09774.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TniB PF05621.11 EDN09774.1 - 0.085 12.3 0.0 0.3 10.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 EDN09774.1 - 0.088 12.4 0.1 2.1 7.8 0.0 2.2 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EDN09774.1 - 0.09 12.5 0.1 0.68 9.7 0.1 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Mito_carr PF00153.27 EDN09775.1 - 4.2e-54 180.5 1.5 5.1e-17 61.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.16 EDN09775.1 - 0.066 13.2 0.1 0.19 11.7 0.1 1.8 1 0 0 1 1 1 0 UcrQ family SNARE_assoc PF09335.11 EDN09775.1 - 0.23 12.0 3.8 3.7 8.1 0.1 3.6 3 1 1 4 4 4 0 SNARE associated Golgi protein WD40 PF00400.32 EDN09776.1 - 1.2e-06 29.1 12.0 0.42 11.6 0.0 7.0 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.8 EDN09776.1 - 0.0048 15.6 0.0 0.031 12.9 0.0 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 ATP-synt_ab PF00006.25 EDN09777.1 - 1.2e-61 208.1 0.0 2.6e-61 207.0 0.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDN09777.1 - 6e-24 84.4 2.2 1.6e-23 83.0 1.5 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 EDN09777.1 - 0.01 15.8 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 EDN09777.1 - 0.01 15.8 0.0 0.049 13.5 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EDN09777.1 - 0.019 14.2 0.3 0.096 11.9 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 EDN09777.1 - 0.027 14.9 0.0 0.87 10.0 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T3SS_ATPase_C PF18269.1 EDN09777.1 - 0.029 14.2 0.8 0.14 12.1 0.8 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 EDN09777.1 - 0.047 14.0 0.8 0.49 10.7 0.2 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDN09777.1 - 0.049 13.5 0.1 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 NACHT domain ATPase PF06745.13 EDN09777.1 - 0.049 13.0 0.1 0.087 12.2 0.1 1.4 1 0 0 1 1 1 0 KaiC EKR PF10371.9 EDN09777.1 - 0.073 12.9 0.9 2.4 8.0 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function AAA_16 PF13191.6 EDN09777.1 - 0.077 13.4 0.3 0.45 10.9 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EDN09777.1 - 0.081 13.3 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Myb_DNA-bind_6 PF13921.6 EDN09779.1 - 0.3 11.4 4.2 1 9.7 4.2 2.0 1 1 0 1 1 1 0 Myb-like DNA-binding domain Myticin-prepro PF10690.9 EDN09780.1 - 1.4 9.2 0.1 1.4 9.2 0.1 2.5 2 1 0 2 2 2 0 Myticin pre-proprotein from the mussel DUF4082 PF13313.6 EDN09781.1 - 0.16 12.0 0.4 0.3 11.1 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4082) Pkinase PF00069.25 EDN09782.1 - 1.7e-33 116.1 0.0 6.5e-33 114.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN09782.1 - 1.1e-14 54.3 0.0 8.6e-14 51.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-binding PF00249.31 EDN09783.1 - 0.012 15.8 4.7 0.031 14.5 4.7 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN09783.1 - 0.016 15.5 3.5 0.038 14.2 3.5 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Fungal_trans_2 PF11951.8 EDN09784.1 - 0.0001 21.3 0.2 0.0001 21.3 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3435 PF11917.8 EDN09785.1 - 6.7e-152 506.2 0.5 1.3e-151 505.3 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) POX PF07526.11 EDN09785.1 - 4.1 8.0 6.6 0.45 11.1 0.6 2.3 2 1 0 2 2 2 0 Associated with HOX Alpha-amylase_C PF02806.18 EDN09786.1 - 9.1e-22 77.3 0.0 2e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EDN09786.1 - 5.6e-17 62.3 0.0 1.1e-11 44.9 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 EDN09786.1 - 6.7e-17 61.6 0.2 1.9e-16 60.2 0.0 1.9 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) adh_short PF00106.25 EDN09787.1 - 9.5e-35 119.8 0.3 4e-34 117.8 0.0 1.9 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN09787.1 - 6.7e-25 88.0 0.0 1e-24 87.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN09787.1 - 1e-05 25.5 2.4 0.00052 20.0 1.1 2.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EDN09787.1 - 0.0081 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3088 PF11287.8 EDN09788.1 - 0.079 12.7 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3088) DUF2012 PF09430.10 EDN09789.1 - 2.8e-23 82.3 0.0 4.4e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) WW PF00397.26 EDN09789.1 - 6.6e-11 42.1 0.7 6.6e-11 42.1 0.7 2.5 2 0 0 2 2 2 1 WW domain DUF5427 PF10310.9 EDN09789.1 - 4.1 6.3 10.9 5.6 5.8 10.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) YhhN PF07947.14 EDN09790.1 - 5.1e-35 120.7 3.1 6.4e-34 117.2 3.1 2.3 1 1 0 1 1 1 1 YhhN family AMP-binding PF00501.28 EDN09791.1 - 1.3e-82 277.6 0.0 1.7e-82 277.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme COX4 PF02936.14 EDN09792.1 - 3.7e-10 40.0 0.3 4e-10 39.9 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Cofilin_ADF PF00241.20 EDN09793.1 - 4.7e-32 110.3 0.1 6e-32 110.0 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Cpn60_TCP1 PF00118.24 EDN09794.1 - 1.4e-86 291.1 15.1 3e-86 290.0 15.1 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5473 PF17567.2 EDN09795.1 - 0.09 13.1 0.1 0.35 11.2 0.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5473) ATP-synt_Eps PF04627.13 EDN09796.1 - 3.7e-23 81.3 1.2 6.2e-23 80.5 1.2 1.4 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain DUF4731 PF15875.5 EDN09796.1 - 0.13 12.5 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4731) Mak10 PF04112.13 EDN09797.1 - 1.3e-62 210.3 0.1 3.5e-62 208.8 0.0 1.8 2 0 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase ORC5_C PF14630.6 EDN09798.1 - 3.4e-81 272.9 0.0 1.8e-80 270.5 0.0 1.9 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EDN09798.1 - 1.8e-22 80.5 0.0 4.4e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDN09798.1 - 0.015 15.6 0.0 0.031 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EDN09798.1 - 0.04 13.0 0.0 0.068 12.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 EDN09798.1 - 0.045 13.7 0.0 7.3 6.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 EDN09798.1 - 0.068 13.2 0.0 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EDN09798.1 - 0.075 13.5 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EDN09798.1 - 0.12 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EDN09798.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin PUF PF00806.19 EDN09801.1 - 5.9e-59 192.6 4.4 1.8e-07 30.4 0.0 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DDE_Tnp_1_7 PF13843.6 EDN09801.1 - 7.8e-11 41.9 0.0 1.6e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1_7 PF13843.6 EDN09802.1 - 2.2e-23 83.2 0.0 3.1e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Transposase IS4 BAT2_N PF07001.11 EDN09803.1 - 0.056 13.9 5.2 3 8.3 1.1 2.5 2 0 0 2 2 2 0 BAT2 N-terminus RNA_pol_Rpb2_6 PF00562.28 EDN09804.1 - 2.6e-122 408.7 0.0 4.3e-122 407.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDN09804.1 - 1e-54 185.2 0.7 1.4e-54 184.7 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EDN09804.1 - 1.5e-31 108.7 0.3 3.4e-31 107.5 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EDN09804.1 - 1e-28 100.3 3.6 1.7e-28 99.6 2.9 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EDN09804.1 - 5.4e-24 84.3 0.4 1.4e-23 82.9 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDN09804.1 - 2.6e-19 69.2 0.0 5.4e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RT_RNaseH PF17917.1 EDN09807.1 - 4.1e-45 152.4 0.3 2.3e-44 149.9 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN09807.1 - 4.8e-33 114.5 0.1 8.1e-33 113.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN09807.1 - 2e-27 95.2 0.0 3.8e-14 52.5 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN09807.1 - 4.3e-19 68.4 0.3 9.4e-19 67.3 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EDN09807.1 - 1.2e-15 57.2 0.5 3.2e-15 55.8 0.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN09807.1 - 7.7e-07 29.3 0.0 1.9e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN09807.1 - 9.9e-05 22.5 0.1 0.00024 21.2 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 EDN09807.1 - 0.057 14.1 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 EDN09807.1 - 0.13 12.9 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Cwf_Cwc_15 PF04889.12 EDN09808.1 - 0.51 10.0 4.0 0.59 9.8 4.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 EDN09808.1 - 0.62 10.5 7.6 0.92 9.9 7.6 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 EDN09808.1 - 2.7 7.0 7.1 3.4 6.7 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-RING_6 PF14835.6 EDN09808.1 - 3.2 7.7 6.2 7.4 6.5 6.2 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Glycos_transf_1 PF00534.20 EDN09809.1 - 7.9e-16 58.1 0.0 2e-15 56.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDN09809.1 - 5.4e-13 49.5 0.0 1e-12 48.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EDN09809.1 - 0.0024 18.2 0.0 0.0051 17.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 ThuA PF06283.11 EDN09809.1 - 0.14 12.4 0.0 0.44 10.7 0.0 1.8 2 0 0 2 2 2 0 Trehalose utilisation E1-E2_ATPase PF00122.20 EDN09810.1 - 1.3e-48 165.0 6.6 1.3e-48 165.0 6.6 3.1 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EDN09810.1 - 8e-17 62.2 0.1 4.3e-16 59.8 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN09810.1 - 3.7e-11 42.5 0.0 8.5e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDN09810.1 - 0.0025 17.6 0.1 0.0048 16.7 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDN09810.1 - 0.024 14.7 0.0 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) O-antigen_lig PF13425.6 EDN09810.1 - 0.056 12.2 6.5 0.14 10.9 6.5 1.6 1 0 0 1 1 1 0 O-antigen ligase like membrane protein OAD_gamma PF04277.13 EDN09810.1 - 4.9 7.8 7.1 16 6.2 1.5 3.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Ribosomal_60s PF00428.19 EDN09810.1 - 8.7 7.0 18.8 1 10.0 13.2 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein RRM_1 PF00076.22 EDN09812.1 - 2.9e-05 23.8 0.0 5.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EDN09813.1 - 1.9e-09 38.2 0.0 3.2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Citrate_synt PF00285.21 EDN09814.1 - 1e-97 327.5 0.0 1.3e-97 327.2 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 EDN09814.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone ALMT PF11744.8 EDN09815.1 - 0.63 8.8 6.4 0.7 8.7 6.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Sin_N PF04801.13 EDN09815.1 - 2.3 7.3 11.9 2.8 7.1 11.9 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region CRT10 PF08728.10 EDN09815.1 - 3.6 5.6 5.9 3.9 5.5 5.9 1.0 1 0 0 1 1 1 0 CRT10 CDC45 PF02724.14 EDN09815.1 - 7.9 4.6 14.4 8.6 4.5 14.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Helitron_like_N PF14214.6 EDN09817.1 - 1.1e-24 87.7 0.1 3.3e-24 86.2 0.1 1.8 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus PIF1 PF05970.14 EDN09817.1 - 4e-19 69.0 0.0 6.4e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.6 EDN09817.1 - 0.0013 18.5 0.0 0.004 16.9 0.0 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 EDN09817.1 - 0.0035 15.3 0.0 0.0051 14.8 0.0 1.2 1 0 0 1 1 1 1 Helicase RNase_H PF00075.24 EDN09818.1 - 4.2e-05 23.8 0.0 6.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.27 EDN09819.1 - 1.2e-18 67.4 0.0 1.6e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN09820.1 - 5e-10 39.3 0.1 7.3e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase GCV_H PF01597.19 EDN09820.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Glycine cleavage H-protein Rep-A_N PF04057.12 EDN09821.1 - 0.096 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain ClpB_D2-small PF10431.9 EDN09822.1 - 0.14 12.2 0.1 6.8 6.8 0.0 2.4 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Mito_carr PF00153.27 EDN09828.1 - 1.2e-27 95.6 3.4 3.8e-12 46.0 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M16 PF00675.20 EDN09829.1 - 1.3e-21 77.1 0.1 2.5e-21 76.2 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDN09829.1 - 2.1e-12 47.4 0.0 4.9e-12 46.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 EDN09829.1 - 0.0048 16.1 0.0 0.065 12.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16C associated RNA_pol_Rpc82 PF05645.13 EDN09830.1 - 7.9e-32 111.0 0.0 1.6e-29 103.4 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EDN09830.1 - 8e-14 51.5 3.8 3.1e-05 24.0 0.3 4.4 3 1 0 3 3 3 3 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EDN09830.1 - 3.9e-11 42.8 1.3 4.4e-07 29.7 0.1 2.6 2 0 0 2 2 2 2 TFIIE alpha subunit HTH_27 PF13463.6 EDN09830.1 - 0.062 13.8 0.3 1.2 9.6 0.0 2.8 3 1 0 3 3 3 0 Winged helix DNA-binding domain F-box-like PF12937.7 EDN09831.1 - 0.00016 21.5 0.5 0.00042 20.2 0.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN09831.1 - 0.056 13.3 0.9 0.19 11.7 0.9 1.9 1 0 0 1 1 1 0 F-box domain DUF4817 PF16087.5 EDN09831.1 - 0.081 12.7 1.1 1 9.2 0.1 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain (DUF4817) Ras PF00071.22 EDN09832.1 - 3.6e-61 205.5 0.9 4.3e-61 205.2 0.9 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN09832.1 - 1.3e-36 125.4 0.2 1.9e-36 124.9 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN09832.1 - 1.6e-14 53.7 0.2 2.1e-14 53.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDN09832.1 - 2.9e-07 30.6 0.1 4.5e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDN09832.1 - 3e-05 23.7 0.3 0.00013 21.6 0.3 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN09832.1 - 0.00035 20.0 0.1 0.00047 19.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EDN09832.1 - 0.0014 18.6 1.7 0.02 14.8 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EDN09832.1 - 0.0068 15.9 0.5 0.057 12.9 0.5 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EDN09832.1 - 0.0076 16.7 0.2 0.016 15.6 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EDN09832.1 - 0.0091 15.7 0.0 0.018 14.8 0.0 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EDN09832.1 - 0.014 15.9 0.1 0.024 15.2 0.1 1.5 1 1 0 1 1 1 0 ABC transporter SRPRB PF09439.10 EDN09832.1 - 0.015 14.7 0.1 0.025 14.0 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EDN09832.1 - 0.018 15.3 0.1 0.068 13.4 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN09832.1 - 0.022 14.5 0.3 0.12 12.1 0.0 2.0 1 1 0 2 2 2 0 AAA domain TniB PF05621.11 EDN09832.1 - 0.073 12.5 0.0 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_18 PF13238.6 EDN09832.1 - 0.075 13.6 0.0 0.18 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EDN09832.1 - 0.094 12.5 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3873 PF12989.7 EDN09832.1 - 0.11 12.9 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) AAA_14 PF13173.6 EDN09832.1 - 0.12 12.5 0.1 0.3 11.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain UDG PF03167.19 EDN09832.1 - 0.14 12.1 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Uracil DNA glycosylase superfamily Chromo PF00385.24 EDN09833.1 - 3.7e-09 36.3 0.1 7.2e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain YL1 PF05764.13 EDN09833.1 - 0.006 16.7 10.9 0.012 15.8 10.9 1.5 1 0 0 1 1 1 1 YL1 nuclear protein AAA_2 PF07724.14 EDN09835.1 - 5.2e-36 124.3 0.0 9.3e-35 120.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EDN09835.1 - 1.9e-13 51.0 0.0 3.5e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EDN09835.1 - 1.6e-08 34.5 0.0 3.3e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EDN09835.1 - 7.3e-06 26.0 0.0 1.6e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDN09835.1 - 0.00086 18.7 0.1 0.014 14.8 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDN09835.1 - 0.0042 16.8 0.0 0.14 11.9 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 EDN09835.1 - 0.0049 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 EDN09835.1 - 0.0059 16.9 0.1 0.032 14.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDN09835.1 - 0.0061 16.3 0.4 0.11 12.2 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDN09835.1 - 0.0069 16.8 2.2 0.0093 16.4 0.1 2.3 3 1 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 EDN09835.1 - 0.0092 15.7 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain MCM PF00493.23 EDN09835.1 - 0.023 13.8 0.1 0.044 12.9 0.1 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_7 PF12775.7 EDN09835.1 - 0.058 12.9 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EDN09835.1 - 0.062 13.7 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EDN09835.1 - 0.15 12.0 0.0 0.4 10.5 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EDN09835.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDN09835.1 - 0.24 11.9 0.0 0.24 11.9 0.0 3.0 3 1 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EDN09835.1 - 1.4 9.0 0.0 1.4 9.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain RVT_1 PF00078.27 EDN09836.1 - 1.8e-40 138.8 0.0 2.8e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN09836.1 - 1.9e-13 50.3 0.0 5.7e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN09836.1 - 0.00028 20.5 0.1 0.00048 19.7 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN09836.1 - 4 7.7 8.7 1.5 9.0 4.8 2.4 2 0 0 2 2 2 0 Zinc knuckle Cys_Met_Meta_PP PF01053.20 EDN09837.1 - 1.1e-148 494.9 0.0 1.3e-148 494.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EDN09837.1 - 1.4e-09 37.8 0.1 2.7e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EDN09837.1 - 7.7e-09 35.2 0.0 1.1e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDN09837.1 - 1.9e-07 30.4 0.1 4.2e-07 29.3 0.1 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDN09837.1 - 0.0089 15.3 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 EDN09837.1 - 0.032 14.5 0.0 0.1 12.8 0.0 1.9 1 1 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain Met_gamma_lyase PF06838.11 EDN09837.1 - 0.043 12.4 0.0 0.058 11.9 0.0 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase GDC-P PF02347.16 EDN09837.1 - 0.073 11.9 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein SepSecS PF05889.13 EDN09837.1 - 0.18 10.4 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS RVT_2 PF07727.14 EDN09839.1 - 1.2e-43 149.5 0.0 1.8e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN09839.1 - 2e-11 44.1 0.1 6.4e-11 42.5 0.1 1.9 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN09839.1 - 0.024 14.4 3.0 0.047 13.4 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN09839.1 - 0.029 14.2 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN09839.1 - 0.087 12.6 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Phage_min_cap2 PF06152.11 EDN09839.1 - 0.33 9.8 1.1 0.56 9.0 1.1 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 CLPTM1 PF05602.12 EDN09840.1 - 0.056 12.5 0.1 0.07 12.1 0.1 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) RNase_H PF00075.24 EDN09841.1 - 1.9e-12 47.6 0.0 3.9e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN09841.1 - 0.083 12.7 0.1 0.26 11.1 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like REV1_C PF16727.5 EDN09842.1 - 0.06 13.7 0.1 0.067 13.6 0.1 1.1 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain DUF865 PF05906.11 EDN09843.1 - 1.9 8.4 9.2 44 4.0 0.0 4.5 2 1 3 5 5 5 0 Herpesvirus-7 repeat of unknown function (DUF865) OrsD PF12013.8 EDN09845.1 - 3e-19 69.5 0.1 7.3e-19 68.3 0.0 1.6 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D DUF3636 PF12331.8 EDN09848.1 - 2.3e-51 173.5 0.0 3.8e-51 172.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) LCD1 PF09798.9 EDN09848.1 - 0.021 13.4 3.8 0.036 12.6 3.2 1.7 1 1 0 1 1 1 0 DNA damage checkpoint protein Mu-like_Pro PF10123.9 EDN09848.1 - 0.43 10.1 5.7 0.65 9.5 5.7 1.2 1 0 0 1 1 1 0 Mu-like prophage I protein DUF755 PF05501.11 EDN09848.1 - 0.56 10.5 3.5 0.91 9.8 2.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF755) Rab5-bind PF09311.11 EDN09848.1 - 0.76 9.1 8.0 1.4 8.2 8.0 1.4 1 0 0 1 1 1 0 Rabaptin-like protein Csm1_N PF18504.1 EDN09848.1 - 1.2 9.5 6.3 1.2 9.6 3.2 2.3 1 1 2 3 3 3 0 Csm1 N-terminal domain FUSC PF04632.12 EDN09848.1 - 1.8 7.0 10.5 1.3 7.5 0.3 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family GDPD PF03009.17 EDN09849.1 - 1.7e-16 60.8 0.0 1e-14 54.9 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family RVT_2 PF07727.14 EDN09852.1 - 5.2e-37 127.8 0.0 7.9e-37 127.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EDN09852.1 - 1.9e-12 46.8 0.3 4.6e-12 45.6 0.3 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EDN09852.1 - 0.0018 18.5 0.0 0.0044 17.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_1_7 PF13843.6 EDN09853.1 - 1.3e-37 130.0 0.3 2.2e-37 129.2 0.0 1.5 2 0 0 2 2 2 1 Transposase IS4 Ribosomal_L3 PF00297.22 EDN09854.1 - 3.8e-14 52.5 0.9 5.5e-14 51.9 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 DUF1772 PF08592.11 EDN09855.1 - 0.011 16.1 4.0 0.65 10.3 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) TMEM208_SND2 PF05620.11 EDN09855.1 - 0.018 14.8 0.9 0.032 14.0 0.9 1.4 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF3378 PF11858.8 EDN09855.1 - 0.18 12.0 0.0 0.62 10.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) CTP_transf_like PF01467.26 EDN09856.1 - 2.7e-23 82.7 0.1 1.3e-20 74.0 0.0 2.9 3 1 1 4 4 4 2 Cytidylyltransferase-like G6PD_bact PF10786.9 EDN09857.1 - 0.024 14.2 0.3 0.03 13.9 0.3 1.1 1 0 0 1 1 1 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) DUF4609 PF15382.6 EDN09857.1 - 0.077 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) DDE_1 PF03184.19 EDN09858.1 - 2.1e-22 79.6 0.0 6e-22 78.1 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN09858.1 - 4.7e-05 23.2 0.0 0.00024 20.9 0.0 2.2 1 1 1 2 2 2 1 DDE superfamily endonuclease PC4 PF02229.16 EDN09861.1 - 2.5e-22 78.2 0.1 3.9e-22 77.6 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) DUF5039 PF16442.5 EDN09861.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) Hydantoinase_B PF02538.14 EDN09862.1 - 1.4e-32 112.8 0.7 1.6e-32 112.7 0.7 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_B PF02538.14 EDN09863.1 - 1.7e-05 23.5 0.0 1.8e-05 23.4 0.0 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Exo_endo_phos_2 PF14529.6 EDN09864.1 - 5.3e-12 45.6 0.0 1.3e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN09864.1 - 0.0058 17.0 0.8 0.029 14.8 0.4 2.0 2 0 0 2 2 2 1 ORF 12 gene product N-terminal SCAN PF02023.17 EDN09865.1 - 0.077 12.8 1.6 0.15 11.9 1.6 1.4 1 0 0 1 1 1 0 SCAN domain ARID PF01388.21 EDN09867.1 - 3.9e-14 53.1 0.0 1.5e-13 51.2 0.0 2.0 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain DDE_1 PF03184.19 EDN09867.1 - 3.3e-06 26.9 0.0 6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Imm-NTF2-2 PF15631.6 EDN09867.1 - 0.072 13.4 0.0 0.38 11.0 0.0 2.0 2 0 0 2 2 2 0 NTF2 fold immunity protein DDE_1 PF03184.19 EDN09868.1 - 4.8e-30 104.5 0.0 2.3e-29 102.3 0.0 2.1 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN09868.1 - 2e-07 30.9 0.0 6.6e-07 29.3 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN09868.1 - 7e-07 28.9 0.0 1.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN09868.1 - 0.00081 19.2 0.0 0.0093 15.7 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EDN09868.1 - 0.0019 17.9 9.8 0.0035 17.0 1.7 2.4 2 0 0 2 2 2 2 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EDN09868.1 - 0.038 13.8 0.4 0.32 10.8 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EDN09868.1 - 0.17 12.1 1.4 0.31 11.2 1.4 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN09868.1 - 0.37 10.5 4.0 0.1 12.4 0.5 1.8 2 0 0 2 2 2 0 Zinc knuckle Zn_clus PF00172.18 EDN09870.1 - 9.1e-10 38.5 10.4 1.4e-09 37.9 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CAP_N PF01213.19 EDN09870.1 - 0.12 11.8 10.1 0.39 10.1 10.1 1.8 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RR_TM4-6 PF06459.12 EDN09870.1 - 1.3 8.8 6.8 2.8 7.7 6.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 EDN09870.1 - 2.8 6.1 19.7 4.2 5.5 19.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 EDN09870.1 - 4.8 6.5 7.8 8.6 5.6 7.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 EDN09870.1 - 6.6 6.7 6.8 14 5.7 6.8 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SRP-alpha_N PF04086.13 EDN09870.1 - 7 6.5 13.2 16 5.3 13.2 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PepSY_TM PF03929.16 EDN09870.1 - 7.4 6.1 8.4 22 4.6 8.4 1.8 1 0 0 1 1 1 0 PepSY-associated TM region ATAD4 PF15321.6 EDN09870.1 - 7.7 7.9 8.7 34 5.8 8.7 2.2 1 1 0 1 1 1 0 ATPase family AAA domain containing 4 SLC12 PF03522.15 EDN09870.1 - 9.4 5.1 8.8 14 4.5 8.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 EDN09870.1 - 9.9 4.8 12.3 16 4.2 12.3 1.3 1 0 0 1 1 1 0 Presenilin RVT_1 PF00078.27 EDN09871.1 - 2.9e-26 92.4 0.0 3e-24 85.8 0.0 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN09871.1 - 4.9e-13 49.0 0.0 1.7e-12 47.2 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN09871.1 - 0.00031 20.3 0.1 0.0006 19.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TFIIA PF03153.13 EDN09871.1 - 9.7 6.1 10.6 28 4.6 10.6 1.8 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNase_H PF00075.24 EDN09872.1 - 6.8e-12 45.8 0.0 1.4e-11 44.7 0.0 1.5 1 1 0 1 1 1 1 RNase H Copper-fist PF00649.18 EDN09873.1 - 1.2e-21 75.9 2.1 1.2e-21 75.9 2.1 2.7 3 1 1 4 4 4 1 Copper fist DNA binding domain PEX11 PF05648.14 EDN09874.1 - 5.6e-76 254.9 0.5 6.2e-76 254.7 0.5 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sugar_tr PF00083.24 EDN09875.1 - 2.2e-30 105.9 29.9 1.9e-21 76.5 5.6 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDN09875.1 - 5.7e-16 58.4 35.5 9.3e-16 57.7 35.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Aminotran_1_2 PF00155.21 EDN09876.1 - 7.3e-43 147.1 0.0 1e-42 146.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Se-cys_synth_N PF12390.8 EDN09876.1 - 0.27 11.5 1.0 6.9 7.0 0.0 2.4 2 0 0 2 2 2 0 Selenocysteine synthase N terminal RPN7 PF10602.9 EDN09877.1 - 9.5e-56 188.2 1.0 1.5e-55 187.6 1.0 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EDN09877.1 - 1.5e-13 51.2 0.0 2.7e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.6 EDN09877.1 - 0.02 14.9 0.9 0.079 13.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDN09877.1 - 0.027 15.3 1.2 0.14 13.0 1.2 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat PEPCK_ATP PF01293.20 EDN09878.1 - 2.1e-209 696.0 0.0 2.5e-209 695.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_25 PF13481.6 EDN09878.1 - 0.0077 15.8 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDN09878.1 - 0.048 14.1 0.0 0.15 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain MRFAP1 PF15155.6 EDN09878.1 - 0.14 12.6 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 MORF4 family-associated protein1 AAA_33 PF13671.6 EDN09878.1 - 0.19 11.9 0.1 0.44 10.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain Mito_carr PF00153.27 EDN09881.1 - 6.7e-54 179.8 3.2 2.2e-18 66.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-Nse PF11789.8 EDN09885.1 - 7.6e-23 80.1 0.7 1.3e-22 79.4 0.7 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDN09885.1 - 0.003 17.6 0.0 0.003 17.6 0.0 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-MIZ PF02891.20 EDN09885.1 - 0.04 13.7 1.0 0.04 13.7 1.0 2.5 2 1 1 3 3 3 0 MIZ/SP-RING zinc finger Cnn_1N PF07989.11 EDN09885.1 - 0.54 10.4 3.1 0.54 10.4 0.7 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Pox_MCEL PF03291.16 EDN09886.1 - 1.2e-66 225.1 0.0 1.7e-45 155.6 0.0 2.8 1 1 1 2 2 2 2 mRNA capping enzyme Methyltransf_25 PF13649.6 EDN09886.1 - 1.2e-09 38.8 0.1 0.0006 20.5 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09886.1 - 1.3e-08 35.4 0.0 3e-07 31.1 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN09886.1 - 1.1e-05 26.0 0.0 0.089 13.5 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09886.1 - 5.8e-05 22.9 0.0 0.0043 16.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN09886.1 - 0.0002 21.3 0.0 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDN09886.1 - 0.00023 20.5 0.0 0.00038 19.7 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Rsm1 PF08600.10 EDN09887.1 - 1.1e-32 112.0 0.2 3e-32 110.6 0.0 1.8 2 0 0 2 2 2 1 Rsm1-like zf-C3HC PF07967.13 EDN09887.1 - 7.2e-21 74.6 0.3 6.4e-17 61.8 0.1 3.5 2 1 1 3 3 3 3 C3HC zinc finger-like zf-CHY PF05495.12 EDN09888.1 - 3.1e-11 43.6 8.4 3.1e-11 43.6 8.4 3.5 2 1 1 3 3 3 1 CHY zinc finger DUF3295 PF11702.8 EDN09891.1 - 9.3e-166 553.0 37.2 1.1e-165 552.8 37.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) Cpn60_TCP1 PF00118.24 EDN09894.1 - 1.1e-160 535.6 3.3 1.2e-160 535.4 3.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CPT PF07931.12 EDN09894.1 - 0.052 13.4 0.5 5.7 6.7 0.1 3.0 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein RVT_2 PF07727.14 EDN09895.1 - 1.7e-43 149.1 0.0 2.3e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN09895.1 - 8.8e-13 48.5 0.2 2.5e-12 47.0 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDN09895.1 - 0.017 15.0 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 GAG-pre-integrase domain NDUFA12 PF05071.16 EDN09895.1 - 0.048 14.5 0.2 0.22 12.4 0.2 2.1 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 zf-C2H2_10 PF16588.5 EDN09896.1 - 0.0086 15.8 3.0 0.015 15.0 3.0 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger Retrotran_gag_2 PF14223.6 EDN09896.1 - 0.029 14.0 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_3 PF14244.6 EDN09896.1 - 0.034 14.0 0.1 0.074 12.9 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN09896.1 - 0.099 12.3 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Phage_min_cap2 PF06152.11 EDN09896.1 - 0.15 10.9 1.5 0.25 10.2 1.5 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 Chromo_shadow PF01393.19 EDN09897.1 - 3.1e-24 84.8 0.8 1.3e-19 70.0 0.2 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 EDN09897.1 - 4.2e-12 45.8 0.1 9.9e-12 44.6 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TOM6p PF15184.6 EDN09897.1 - 0.056 13.2 0.2 0.094 12.5 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog BRCT_2 PF16589.5 EDN09898.1 - 5.1e-10 39.6 0.0 1.4e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-bind_2 PF08914.11 EDN09898.1 - 6.4e-08 32.7 0.1 2.2e-07 31.0 0.1 2.0 1 1 1 2 2 2 1 Rap1 Myb domain Rap1_C PF11626.8 EDN09898.1 - 0.022 14.9 0.2 0.6 10.2 0.0 2.5 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Glyco_transf_21 PF13506.6 EDN09899.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 21 DHHC PF01529.20 EDN09900.1 - 0.00069 19.7 0.1 0.00088 19.4 0.1 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase Atx10homo_assoc PF09759.9 EDN09901.1 - 2.6e-31 107.5 1.8 2.8e-31 107.5 0.2 1.9 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain zf-RING_2 PF13639.6 EDN09902.1 - 8.4e-08 32.4 1.6 1.3e-07 31.8 1.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDN09902.1 - 5.6e-05 23.4 4.2 0.00063 20.0 3.6 2.2 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDN09902.1 - 0.00024 21.0 4.9 0.00042 20.3 4.9 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDN09902.1 - 0.0025 17.6 1.7 0.0051 16.6 1.5 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDN09902.1 - 0.015 15.3 0.3 0.024 14.7 0.3 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EDN09902.1 - 0.21 11.5 0.7 0.75 9.7 0.7 1.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDN09902.1 - 0.25 11.1 1.2 0.49 10.2 1.2 1.5 1 0 0 1 1 1 0 RING-like zinc finger Putative_PNPOx PF01243.20 EDN09903.1 - 3.1e-05 24.1 0.0 0.14 12.3 0.0 2.5 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EDN09903.1 - 0.0098 16.2 0.0 0.24 11.7 0.0 2.7 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain Squash PF00299.18 EDN09905.1 - 0.079 13.0 15.8 1.3 9.2 4.0 2.4 2 0 0 2 2 2 0 Squash family serine protease inhibitor Nodulin_late PF07127.11 EDN09905.1 - 0.08 13.3 8.2 0.32 11.4 0.9 2.2 2 0 0 2 2 2 0 Late nodulin protein Gamma-thionin PF00304.20 EDN09905.1 - 1.1 9.6 21.5 3.4 8.0 6.3 2.5 2 0 0 2 2 2 0 Gamma-thionin family Bys1 PF04681.12 EDN09906.1 - 1.7e-16 60.6 0.0 2e-16 60.3 0.0 1.0 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein NTP_transferase PF00483.23 EDN09908.1 - 8.6e-22 77.9 0.0 1.4e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EDN09908.1 - 3e-08 33.1 7.7 1.9e-06 27.4 0.1 3.5 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EDN09908.1 - 0.00027 21.4 0.0 0.00041 20.7 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 EDN09908.1 - 0.0099 14.9 0.3 2.3 7.1 0.1 2.2 2 0 0 2 2 2 2 L-fucokinase Glycos_transf_2 PF00535.26 EDN09908.1 - 0.023 14.5 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Hexapep_2 PF14602.6 EDN09908.1 - 0.036 13.8 0.9 0.33 10.8 0.0 2.7 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Dynamin_N PF00350.23 EDN09909.1 - 1.2e-21 77.5 0.0 4e-21 75.8 0.0 1.9 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EDN09909.1 - 4.7e-21 75.3 0.1 1.9e-16 60.2 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EDN09909.1 - 0.0035 17.4 0.0 0.074 13.1 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EDN09909.1 - 0.011 15.9 4.7 0.22 11.7 2.2 2.9 2 1 0 2 2 2 0 Dynamin GTPase effector domain IIGP PF05049.13 EDN09909.1 - 0.016 14.3 0.1 0.92 8.5 0.0 2.2 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Roc PF08477.13 EDN09909.1 - 0.095 12.9 0.0 0.35 11.1 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase tRNA-synt_2 PF00152.20 EDN09910.1 - 8.7e-79 264.8 0.8 1.1e-78 264.4 0.8 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDN09910.1 - 2.4e-12 46.6 0.2 5.2e-11 42.4 0.0 2.8 2 1 1 3 3 3 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDN09910.1 - 2.8e-05 23.7 0.0 0.03 13.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Mating_C PF12737.7 EDN09910.1 - 0.19 10.9 3.0 0.27 10.4 3.0 1.1 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 RNA_pol_Rpc4 PF05132.14 EDN09910.1 - 0.46 10.9 4.2 0.94 9.9 4.2 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 zf-RanBP PF00641.18 EDN09911.1 - 0.0094 15.3 5.5 0.031 13.6 5.5 2.0 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-B_box PF00643.24 EDN09911.1 - 0.07 13.3 5.7 0.17 12.1 5.7 1.6 1 0 0 1 1 1 0 B-box zinc finger Prok-RING_2 PF14445.6 EDN09911.1 - 0.54 10.5 5.2 1.2 9.4 5.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 zf-RING_4 PF14570.6 EDN09911.1 - 2.3 8.1 11.7 0.17 11.7 5.0 2.5 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain COX15-CtaA PF02628.15 EDN09912.1 - 4e-113 377.8 3.3 4.8e-113 377.5 3.3 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein BTB PF00651.31 EDN09913.1 - 0.00079 19.6 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Zn_clus PF00172.18 EDN09914.1 - 3.4e-06 27.1 8.7 7.3e-06 26.0 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UBZ_FAAP20 PF15750.5 EDN09914.1 - 0.052 13.5 0.2 0.15 12.0 0.2 1.7 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger adh_short PF00106.25 EDN09915.1 - 5.2e-26 91.3 0.0 6.9e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN09915.1 - 1e-19 71.0 0.0 1.4e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN09915.1 - 9.7e-14 51.7 0.1 1.4e-13 51.2 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDN09915.1 - 3.6e-05 23.1 0.0 5e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDN09915.1 - 4.3e-05 23.1 0.0 0.00013 21.6 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDN09915.1 - 0.04 13.3 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Capsule_synth PF05159.14 EDN09915.1 - 0.13 11.7 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Capsule polysaccharide biosynthesis protein Glyoxalase PF00903.25 EDN09916.1 - 3.6e-24 85.4 1.8 4.1e-16 59.3 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDN09916.1 - 9.3e-16 58.1 0.5 2.5e-07 30.9 0.2 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EDN09916.1 - 3.5e-07 30.5 0.3 0.0086 16.2 0.5 2.8 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EDN09916.1 - 0.00012 22.2 0.2 0.0035 17.5 0.2 2.4 1 1 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal TPR_7 PF13176.6 EDN09916.1 - 0.1 12.7 0.1 32 4.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat HgmA PF04209.13 EDN09918.1 - 1.7e-205 682.6 0.0 2e-205 682.4 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase FAD_binding_3 PF01494.19 EDN09919.1 - 8e-14 51.6 0.0 1.8e-13 50.5 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EDN09919.1 - 0.00068 19.0 0.1 0.17 11.1 0.0 3.3 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN09919.1 - 0.0012 19.4 0.0 5 7.8 0.0 4.0 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDN09919.1 - 0.0067 16.0 0.8 2 7.9 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDN09919.1 - 0.0073 15.4 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EDN09919.1 - 0.11 12.7 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Oxidored_FMN PF00724.20 EDN09920.1 - 1.4e-59 202.1 0.0 1.7e-59 201.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EDN09920.1 - 0.13 11.4 0.2 0.57 9.2 0.0 1.9 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) BATS PF06968.13 EDN09922.1 - 9.6e-24 83.4 1.6 3.5e-23 81.5 0.0 2.7 3 1 0 3 3 3 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EDN09922.1 - 4.2e-15 56.5 0.0 3.7e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Aminotran_3 PF00202.21 EDN09923.1 - 2.6e-35 121.9 0.0 2.9e-16 59.1 0.0 3.1 2 1 1 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 EDN09923.1 - 3.3e-11 43.4 0.0 1.3e-08 34.9 0.0 2.3 1 1 1 2 2 2 2 AAA domain Aminotran_1_2 PF00155.21 EDN09924.1 - 1.6e-34 119.7 0.0 1.8e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.21 EDN09924.1 - 0.00046 19.0 0.0 0.00057 18.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Cys_Met_Meta_PP PF01053.20 EDN09924.1 - 0.0028 16.2 0.0 0.0041 15.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDN09924.1 - 0.019 13.9 0.0 0.23 10.4 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class-V Tht1 PF04163.12 EDN09925.1 - 3.2e-09 36.1 0.1 4.6e-09 35.6 0.1 1.2 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein Ribosomal_L6 PF00347.23 EDN09926.1 - 6.5e-23 81.2 0.0 9.5e-12 45.4 0.0 2.4 2 1 0 2 2 2 2 Ribosomal protein L6 Inositol_P PF00459.25 EDN09927.1 - 8.8e-34 117.3 0.5 1.2e-32 113.5 0.5 2.4 1 1 0 1 1 1 1 Inositol monophosphatase family VHS PF00790.19 EDN09928.1 - 1.1e-17 64.3 0.0 2.3e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EDN09928.1 - 1.3e-06 28.6 1.5 3.4e-06 27.3 1.5 1.8 1 0 0 1 1 1 1 GAT domain HEPN_Apea PF18739.1 EDN09928.1 - 0.078 13.4 0.3 0.88 10.0 0.1 2.7 3 1 0 3 3 3 0 Apea-like HEPN DEAD PF00270.29 EDN09929.1 - 4.5e-43 147.0 0.0 9.2e-43 146.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN09929.1 - 1.1e-27 96.6 0.0 2.7e-26 92.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDN09929.1 - 1.4e-05 25.2 2.6 4e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN09929.1 - 0.031 14.5 0.5 0.1 12.8 0.5 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDN09929.1 - 0.23 11.2 6.4 2.9 7.6 0.0 3.2 3 1 0 3 3 3 0 AAA domain FtsJ PF01728.19 EDN09930.1 - 2.6e-63 213.3 0.0 3.2e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase FAD_binding_1 PF00667.20 EDN09931.1 - 1.8e-64 217.4 0.0 2.8e-64 216.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EDN09931.1 - 2.6e-09 37.7 0.0 6e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.18 EDN09931.1 - 1.4e-08 35.0 0.0 2.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 EDN09931.1 - 0.00012 22.3 0.1 0.00025 21.3 0.1 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 EDN09931.1 - 0.0016 18.3 0.0 0.0046 16.8 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain ECH_1 PF00378.20 EDN09931.1 - 0.097 12.0 0.1 0.63 9.3 0.0 2.0 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase HMGL-like PF00682.19 EDN09935.1 - 3e-11 43.4 0.0 5.4e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 HMGL-like Proteasome PF00227.26 EDN09936.1 - 1.6e-59 200.6 0.1 2e-59 200.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDN09936.1 - 3.8e-13 48.8 0.1 8.7e-13 47.7 0.1 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.14 EDN09936.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit DUF5624 PF18538.1 EDN09936.1 - 0.021 14.9 0.1 0.052 13.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) FF PF01846.19 EDN09937.1 - 1.5e-12 47.4 11.3 2.4e-09 37.2 0.5 3.4 3 0 0 3 3 3 2 FF domain VGLL4 PF15245.6 EDN09937.1 - 0.072 13.2 0.3 0.13 12.4 0.3 1.3 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 Mucin_bdg PF03272.13 EDN09937.1 - 0.13 12.2 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 Putative mucin or carbohydrate-binding module LAP1C PF05609.12 EDN09938.1 - 0.53 9.3 11.3 0.66 9.0 11.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SPOC PF07744.13 EDN09939.1 - 9.6e-26 90.5 0.0 1.7e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 EDN09939.1 - 2.7e-23 82.6 0.1 2.7e-23 82.6 0.1 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EDN09939.1 - 1.5e-10 40.8 12.2 2.6e-10 40.0 12.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 EDN09939.1 - 0.0083 16.5 2.4 0.041 14.3 2.4 2.3 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx HEAT_2 PF13646.6 EDN09939.1 - 0.055 13.9 0.6 2.8 8.4 0.2 2.9 3 0 0 3 3 3 0 HEAT repeats PHD_2 PF13831.6 EDN09939.1 - 0.058 13.0 4.0 0.1 12.2 4.0 1.4 1 0 0 1 1 1 0 PHD-finger Terminase_GpA PF05876.12 EDN09939.1 - 0.11 11.0 6.6 0.18 10.3 6.6 1.2 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) CEBP_ZZ PF16366.5 EDN09939.1 - 0.51 10.6 5.1 0.97 9.7 5.1 1.4 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zinc_ribbon_10 PF10058.9 EDN09939.1 - 1.3 8.9 6.0 2.4 8.0 6.0 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein LUC7 PF03194.15 EDN09940.1 - 3.4e-73 246.4 0.3 4.1e-73 246.1 0.3 1.0 1 0 0 1 1 1 1 LUC7 N_terminus MCPsignal PF00015.21 EDN09940.1 - 0.0045 16.8 0.0 0.0067 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2130 PF09903.9 EDN09940.1 - 0.023 14.0 0.4 0.038 13.3 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) DASH_Duo1 PF08651.10 EDN09940.1 - 0.025 14.3 0.1 0.052 13.3 0.1 1.5 1 0 0 1 1 1 0 DASH complex subunit Duo1 Sec8_exocyst PF04048.14 EDN09940.1 - 0.04 13.8 0.2 0.069 13.0 0.2 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain T4SS PF07996.11 EDN09940.1 - 0.077 13.4 0.1 0.22 11.9 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion system proteins Occludin_ELL PF07303.13 EDN09940.1 - 0.084 13.6 1.0 0.74 10.6 0.2 2.5 3 0 0 3 3 3 0 Occludin homology domain HMMR_N PF15905.5 EDN09940.1 - 0.09 12.2 1.1 0.12 11.8 1.1 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Syntaxin_2 PF14523.6 EDN09940.1 - 0.13 12.6 1.0 0.27 11.6 1.0 1.5 1 0 0 1 1 1 0 Syntaxin-like protein DUF948 PF06103.11 EDN09940.1 - 0.17 12.1 0.1 0.32 11.3 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Gpi16 PF04113.14 EDN09941.1 - 3.9e-240 798.1 0.0 4.8e-240 797.8 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component HECT PF00632.25 EDN09943.1 - 9.9e-78 261.7 0.0 3.1e-77 260.1 0.0 1.8 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) BUD22 PF09073.10 EDN09943.1 - 0.0013 18.2 5.9 0.0013 18.2 5.9 3.5 3 1 1 4 4 4 1 BUD22 CLASP_N PF12348.8 EDN09943.1 - 0.063 12.8 0.9 0.82 9.2 0.0 2.5 3 0 0 3 3 3 0 CLASP N terminal Clr5 PF14420.6 EDN09943.1 - 0.14 12.4 0.1 0.53 10.5 0.1 2.0 1 0 0 1 1 1 0 Clr5 domain HEAT PF02985.22 EDN09943.1 - 0.17 12.2 0.2 8.5 6.9 0.0 3.7 4 0 0 4 4 4 0 HEAT repeat Arm PF00514.23 EDN09943.1 - 1.5 9.0 9.3 41 4.4 0.1 5.8 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat CTP_transf_like PF01467.26 EDN09944.1 - 3.1e-24 85.8 0.0 4.3e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like HAD PF12710.7 EDN09945.1 - 3.6e-23 82.9 0.0 4.5e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EDN09945.1 - 0.0009 18.8 0.1 0.0048 16.4 0.0 2.0 1 1 0 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EDN09945.1 - 0.0026 17.2 0.1 0.2 11.0 0.1 2.1 2 0 0 2 2 2 2 Putative Phosphatase DUF2357 PF09823.9 EDN09945.1 - 0.064 12.5 0.0 0.092 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) TFR_dimer PF04253.15 EDN09946.1 - 7.9e-24 84.1 0.0 1.3e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDN09946.1 - 1.3e-15 57.6 0.0 2.3e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDN09946.1 - 4.2e-09 36.3 0.3 2.2e-08 34.0 0.3 2.1 1 1 0 1 1 1 1 PA domain Nicastrin PF05450.15 EDN09946.1 - 0.00027 20.5 0.0 0.00046 19.7 0.0 1.3 1 0 0 1 1 1 1 Nicastrin Peptidase_M20 PF01546.28 EDN09946.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 HCBP_related PF06594.11 EDN09946.1 - 0.44 10.5 2.1 0.91 9.5 0.0 2.5 3 0 0 3 3 3 0 Haemolysin-type calcium binding protein related domain SIS PF01380.22 EDN09948.1 - 5.3e-12 45.7 0.0 1.3e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EDN09948.1 - 7e-06 26.1 0.1 2.3e-05 24.4 0.1 1.8 1 1 1 2 2 2 1 SIS domain Ubie_methyltran PF01209.18 EDN09949.1 - 2.6e-80 269.1 0.0 3.2e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDN09949.1 - 3.5e-16 59.7 0.0 8e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN09949.1 - 7.3e-14 52.2 0.0 1.9e-13 50.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN09949.1 - 7.4e-14 51.8 0.0 1.1e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN09949.1 - 7.8e-10 39.4 0.0 1.5e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN09949.1 - 2.6e-08 33.9 0.0 3.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EDN09949.1 - 0.047 13.5 0.0 0.34 10.7 0.0 2.0 2 0 0 2 2 2 0 Hypothetical methyltransferase Fungal_trans_2 PF11951.8 EDN09951.1 - 4.8e-38 131.0 0.0 6.9e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN09951.1 - 7.1e-09 35.6 7.9 1.4e-08 34.7 7.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos PF03372.23 EDN09954.1 - 1.4e-08 34.6 0.1 1.9e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FAM176 PF14851.6 EDN09955.1 - 0.13 11.9 2.5 0.18 11.4 2.5 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EDN09955.1 - 0.22 9.7 1.0 0.21 9.8 1.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EDN09955.1 - 0.71 9.1 6.9 0.91 8.8 6.9 1.1 1 0 0 1 1 1 0 NOA36 protein NESP55 PF06390.12 EDN09955.1 - 1.3 8.6 21.7 0.17 11.4 3.0 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) Pox_Ag35 PF03286.14 EDN09955.1 - 1.5 8.5 8.0 2 8.2 8.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.11 EDN09955.1 - 3.8 6.3 6.1 4.9 5.9 6.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DNA_pol_phi PF04931.13 EDN09955.1 - 4.9 5.1 8.6 5.7 4.9 8.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi Trypan_PARP PF05887.11 EDN09955.1 - 5.1 7.1 28.8 0.071 13.1 3.5 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) E1_dh PF00676.20 EDN09958.1 - 5.7e-87 291.4 0.0 7.3e-87 291.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EDN09958.1 - 0.00031 20.6 0.1 0.0029 17.4 0.1 2.3 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.10 EDN09958.1 - 0.0067 15.3 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 XFP N-terminal domain DUF737 PF05300.11 EDN09959.1 - 0.016 15.6 0.9 0.016 15.6 0.9 4.0 2 1 0 2 2 2 0 Protein of unknown function (DUF737) ATG16 PF08614.11 EDN09959.1 - 0.017 15.3 0.3 0.017 15.3 0.3 3.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 EDN09959.1 - 0.28 11.6 3.3 0.58 10.6 3.3 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Complex1_30kDa PF00329.19 EDN09961.1 - 8.4e-43 145.9 0.0 1.2e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Fungal_trans PF04082.18 EDN09962.1 - 1.3e-20 73.6 0.1 2.3e-20 72.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN09962.1 - 4.5e-06 26.7 10.1 8.4e-06 25.8 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BUD22 PF09073.10 EDN09963.1 - 1.8e-57 195.6 21.1 2.1e-57 195.4 21.1 1.0 1 0 0 1 1 1 1 BUD22 FAM184 PF15665.5 EDN09964.1 - 0.0016 18.3 31.3 0.0016 18.3 31.3 4.0 1 1 3 4 4 4 1 Family with sequence similarity 184, A and B RE_HaeIII PF09556.10 EDN09964.1 - 0.46 9.5 12.2 0.22 10.6 0.5 3.5 1 1 1 3 3 3 0 HaeIII restriction endonuclease Guanylate_cyc_2 PF09778.9 EDN09964.1 - 1.6 8.1 5.5 0.72 9.2 2.1 2.1 1 1 1 2 2 2 0 Guanylylate cyclase ApoO PF09769.9 EDN09964.1 - 2.7 7.9 19.1 13 5.7 2.0 4.3 1 1 3 4 4 4 0 Apolipoprotein O Baculo_PEP_C PF04513.12 EDN09964.1 - 4.8 7.2 21.1 4.5 7.3 0.1 4.3 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus PNP_UDP_1 PF01048.20 EDN09965.1 - 1.4e-39 135.7 0.2 1.7e-39 135.5 0.2 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Glyco_hydro_3_C PF01915.22 EDN09966.1 - 2.6e-45 154.9 0.0 5.8e-45 153.8 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EDN09966.1 - 1.6e-38 132.9 0.0 3.5e-38 131.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EDN09966.1 - 2.8e-18 65.8 0.6 5e-18 65.0 0.6 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF572 PF04502.13 EDN09967.1 - 4.6e-68 230.3 0.0 5.2e-68 230.1 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) PTPA PF03095.15 EDN09968.1 - 8.1e-108 360.4 0.0 1.5e-106 356.3 0.0 2.0 1 1 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein SANT_DAMP1_like PF16282.5 EDN09969.1 - 0.023 14.9 0.0 0.054 13.7 0.0 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 EDN09969.1 - 0.025 14.8 0.0 0.076 13.2 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Tropomyosin_1 PF12718.7 EDN09971.1 - 0.00031 20.9 14.5 0.00031 20.9 14.5 10.0 1 1 9 10 10 10 2 Tropomyosin like Filament PF00038.21 EDN09971.1 - 0.0051 16.4 22.1 0.0051 16.4 22.1 7.2 1 1 5 6 6 6 1 Intermediate filament protein ATG16 PF08614.11 EDN09971.1 - 0.01 16.1 27.9 0.01 16.1 27.9 9.9 3 1 7 10 10 10 0 Autophagy protein 16 (ATG16) HAMP PF00672.25 EDN09971.1 - 0.1 13.0 1.8 0.95 9.9 0.0 3.2 2 0 0 2 2 2 0 HAMP domain Rad4 PF03835.15 EDN09972.1 - 9.2e-38 129.2 0.1 1.8e-37 128.3 0.1 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EDN09972.1 - 3.1e-25 88.4 0.1 5.8e-25 87.5 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EDN09972.1 - 1.1e-20 73.2 0.2 2.5e-20 72.0 0.2 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EDN09972.1 - 7.4e-17 62.1 3.7 1.1e-16 61.6 0.2 3.1 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EDN09972.1 - 0.0046 17.4 0.0 0.029 14.8 0.0 2.3 2 1 0 2 2 2 1 Transglutaminase-like superfamily BSD PF03909.17 EDN09973.1 - 4.2e-19 68.3 0.8 9.7e-19 67.1 0.8 1.7 1 0 0 1 1 1 1 BSD domain Ran-binding PF05508.11 EDN09974.1 - 6.8e-124 412.9 2.0 8.7e-124 412.5 2.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein GTP_EFTU PF00009.27 EDN09975.1 - 5.1e-41 140.4 0.0 7.9e-41 139.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDN09975.1 - 2.4e-28 98.7 0.0 5.7e-28 97.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDN09975.1 - 2e-09 37.7 0.6 4.5e-09 36.6 0.6 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDN09975.1 - 0.052 13.6 0.0 0.2 11.7 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Hamartin PF04388.12 EDN09975.1 - 0.14 10.8 5.9 0.21 10.2 5.9 1.2 1 0 0 1 1 1 0 Hamartin protein SRP-alpha_N PF04086.13 EDN09975.1 - 0.28 11.1 9.7 0.62 9.9 9.7 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TFIIF_alpha PF05793.12 EDN09975.1 - 1.5 7.3 7.4 2.5 6.6 7.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) WGG PF10273.9 EDN09976.1 - 8.6e-31 106.4 0.1 1.8e-30 105.4 0.1 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 cwf18 PF08315.12 EDN09976.1 - 0.027 15.1 0.2 0.027 15.1 0.2 1.5 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor DUF4637 PF15470.6 EDN09976.1 - 0.14 11.9 4.0 0.25 11.1 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sporozoite_P67 PF05642.11 EDN09976.1 - 0.19 9.8 4.4 0.28 9.2 4.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 EDN09976.1 - 0.47 9.7 6.2 0.64 9.3 6.2 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EDN09976.1 - 0.56 8.4 2.6 0.66 8.2 2.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EDN09976.1 - 4.5 5.4 8.9 5.1 5.2 8.9 1.1 1 0 0 1 1 1 0 Nop14-like family Abhydrolase_3 PF07859.13 EDN09978.1 - 3.7e-25 89.0 0.2 3.8e-15 56.3 0.0 3.0 3 1 0 3 3 3 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDN09978.1 - 1.4e-12 47.2 0.0 3.1e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EDN09978.1 - 0.0044 16.3 0.0 0.01 15.1 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 ParA PF10609.9 EDN09979.1 - 1.1e-77 260.8 0.0 8.3e-69 231.8 0.0 2.9 2 1 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDN09979.1 - 4.3e-07 30.0 0.0 3.6e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDN09979.1 - 7e-05 22.8 0.1 0.00071 19.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 EDN09979.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 ATPase MipZ Ogr_Delta PF04606.12 EDN09979.1 - 0.15 12.1 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger ArsA_ATPase PF02374.15 EDN09979.1 - 0.22 10.6 0.1 0.74 8.9 0.2 1.8 3 0 0 3 3 3 0 Anion-transporting ATPase TRAUB PF08164.12 EDN09980.1 - 5.5e-30 103.7 0.0 2.3e-29 101.8 0.0 2.2 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EDN09980.1 - 8.2e-26 91.3 0.5 8.2e-26 91.3 0.5 3.0 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor Tudor_3 PF18115.1 EDN09981.1 - 6e-07 29.2 0.0 1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 EDN09981.1 - 0.00066 19.7 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) FH2 PF02181.23 EDN09981.1 - 0.066 12.3 0.4 0.087 11.9 0.4 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain TUDOR PF00567.24 EDN09981.1 - 0.093 12.8 0.0 0.53 10.3 0.0 2.0 2 0 0 2 2 2 0 Tudor domain MDH PF02315.16 EDN09982.1 - 0.1 12.7 0.0 0.41 10.7 0.0 2.0 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit PAP1 PF08601.10 EDN09983.1 - 9.4e-99 331.6 14.8 2.9e-81 274.1 0.6 3.2 3 0 0 3 3 3 3 Transcription factor PAP1 bZIP_1 PF00170.21 EDN09983.1 - 2.1e-08 34.1 12.6 4.5e-08 33.1 12.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 EDN09983.1 - 0.0033 17.2 3.9 0.0062 16.3 3.9 1.4 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 DUF16 PF01519.16 EDN09983.1 - 0.016 15.7 1.0 0.046 14.2 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF16 bZIP_2 PF07716.15 EDN09983.1 - 0.051 13.7 15.6 0.28 11.3 14.4 2.3 1 1 1 2 2 2 0 Basic region leucine zipper bZIP_Maf PF03131.17 EDN09983.1 - 0.06 13.9 10.0 0.14 12.7 10.0 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor TolA_bind_tri PF16331.5 EDN09983.1 - 0.063 13.4 1.4 0.16 12.0 1.4 1.7 1 0 0 1 1 1 0 TolA binding protein trimerisation Spc29 PF17082.5 EDN09983.1 - 0.11 12.3 7.4 0.02 14.7 2.4 2.1 2 0 0 2 2 2 0 Spindle Pole Component 29 EMP24_GP25L PF01105.24 EDN09983.1 - 2.8 7.9 5.4 0.3 11.0 0.6 1.7 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD UPF0242 PF06785.11 EDN09983.1 - 4.8 7.2 6.9 9.4 6.3 6.7 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF2433 PF10360.9 EDN09984.1 - 1.8e-26 92.7 0.0 3.4e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos PF00149.28 EDN09984.1 - 0.00044 20.8 0.0 0.0013 19.3 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN09984.1 - 0.0029 17.8 0.0 0.0097 16.1 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Peptidase_M35 PF02102.15 EDN09985.1 - 8.2e-79 265.1 8.3 1.1e-78 264.7 8.3 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EDN09985.1 - 3.4e-33 115.2 2.2 3.4e-33 115.2 2.2 1.6 2 0 0 2 2 2 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EDN09985.1 - 0.00035 20.2 3.7 0.00087 18.9 3.7 1.6 1 1 0 1 1 1 1 Putative peptidase family CARDB PF07705.11 EDN09985.1 - 0.034 14.4 0.2 0.077 13.3 0.2 1.6 1 0 0 1 1 1 0 CARDB Patched PF02460.18 EDN09986.1 - 4.5e-74 250.0 11.3 3.1e-73 247.2 11.3 1.9 1 1 0 1 1 1 1 Patched family NPC1_N PF16414.5 EDN09986.1 - 9.9e-55 185.7 1.6 1.6e-54 185.1 1.6 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 EDN09986.1 - 5.1e-53 179.0 4.2 5.1e-53 179.0 4.2 2.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EDN09986.1 - 3.9e-07 29.3 8.1 3.9e-07 29.3 8.1 3.2 3 0 0 3 3 3 2 MMPL family Folate_rec PF03024.14 EDN09986.1 - 0.00068 19.5 1.8 0.0014 18.5 1.8 1.5 1 0 0 1 1 1 1 Folate receptor family DUF3593 PF12159.8 EDN09986.1 - 3.3 7.8 9.9 0.7 10.0 4.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3593) HEAT_2 PF13646.6 EDN09987.1 - 1.3e-22 79.9 0.3 2.5e-05 24.6 0.0 7.9 5 3 3 8 8 8 5 HEAT repeats HEAT_EZ PF13513.6 EDN09987.1 - 4.5e-21 74.9 13.6 8.2e-08 32.6 0.0 9.9 10 3 3 13 13 13 5 HEAT-like repeat HEAT PF02985.22 EDN09987.1 - 2.7e-20 70.7 0.4 0.00014 21.8 0.0 9.3 9 0 0 9 9 8 3 HEAT repeat Cnd1 PF12717.7 EDN09987.1 - 1.4e-12 48.0 0.3 0.021 14.9 0.0 5.0 3 2 2 5 5 5 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDN09987.1 - 3e-10 40.6 0.5 0.79 10.4 0.0 7.5 7 2 2 9 9 8 3 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 EDN09987.1 - 2.2e-09 37.1 2.4 4.6e-08 32.9 0.1 3.4 3 0 0 3 3 3 1 Importin-beta N-terminal domain MMS19_C PF12460.8 EDN09987.1 - 8.3e-08 31.8 0.0 0.0095 15.1 0.0 4.1 3 2 1 4 4 4 2 RNAPII transcription regulator C-terminal ParcG PF10274.9 EDN09987.1 - 0.00011 22.4 0.2 0.13 12.4 0.1 3.4 3 1 0 3 3 3 1 Parkin co-regulated protein RTP1_C1 PF10363.9 EDN09987.1 - 0.00024 21.3 1.7 1.9 8.7 0.1 4.8 4 1 1 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EDN09987.1 - 0.00062 19.4 0.0 1.1 8.7 0.0 3.5 2 1 1 3 3 3 2 CLASP N terminal UNC45-central PF11701.8 EDN09987.1 - 0.00064 19.7 0.2 0.006 16.5 0.2 2.9 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central Adaptin_N PF01602.20 EDN09987.1 - 0.0033 16.0 0.3 9.4 4.7 0.0 4.2 2 2 2 4 4 4 1 Adaptin N terminal region Arm PF00514.23 EDN09987.1 - 0.0084 16.1 0.0 10 6.3 0.0 4.6 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat RIX1 PF08167.12 EDN09987.1 - 0.024 14.4 0.0 2.9 7.6 0.0 3.6 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis RsbRD_N PF14361.6 EDN09987.1 - 0.27 12.0 1.6 1.4e+02 3.3 0.0 4.7 5 0 0 5 5 5 0 RsbT co-antagonist protein rsbRD N-terminal domain DUF3295 PF11702.8 EDN09987.1 - 4.2 6.6 5.0 6.8 5.9 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) ADH_zinc_N_2 PF13602.6 EDN09988.1 - 3.1e-13 50.9 0.0 8.9e-13 49.5 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDN09988.1 - 9.3e-10 38.6 0.0 1.9e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EDN09988.1 - 0.0098 15.8 0.1 0.035 14.0 0.0 2.0 2 1 0 2 2 2 1 N-terminal domain of oxidoreductase Abhydrolase_3 PF07859.13 EDN09989.1 - 1.1e-20 74.4 1.3 3.8e-20 72.6 1.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDN09989.1 - 9.2e-11 41.2 0.0 4.1e-10 39.1 0.0 1.8 1 1 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 EDN09989.1 - 0.044 12.7 0.1 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family COesterase PF00135.28 EDN09992.1 - 8.5e-69 232.8 0.0 2.3e-53 181.9 0.0 2.1 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EDN09992.1 - 0.046 13.6 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold F-actin_cap_A PF01267.17 EDN09993.1 - 6e-75 252.1 0.0 1.6e-42 145.8 0.0 2.0 1 1 1 2 2 2 2 F-actin capping protein alpha subunit ELO PF01151.18 EDN09995.1 - 1.2e-09 38.1 13.9 1.8e-09 37.5 13.9 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family DAD PF02109.16 EDN09995.1 - 0.32 11.3 4.7 0.096 13.0 1.2 1.9 2 0 0 2 2 2 0 DAD family PAP2 PF01569.21 EDN09996.1 - 8.8e-28 96.8 0.9 8.8e-28 96.8 0.9 2.2 2 0 0 2 2 2 1 PAP2 superfamily AveC_like PF17198.4 EDN09996.1 - 0.036 13.5 1.3 0.097 12.1 0.9 1.8 2 0 0 2 2 2 0 Spirocyclase AveC-like PAP2_3 PF14378.6 EDN09996.1 - 0.056 13.1 8.7 0.064 12.9 6.5 2.1 1 1 0 1 1 1 0 PAP2 superfamily Phage_holin_2_4 PF16082.5 EDN09996.1 - 0.22 11.3 0.4 0.89 9.3 0.0 2.1 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like DUF2070 PF09843.9 EDN09996.1 - 2.1 6.5 7.1 30 2.7 0.0 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2070) Goodbye PF17109.5 EDN09997.1 - 2.8e-06 27.8 0.0 6.6e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain NACHT PF05729.12 EDN09997.1 - 3.9e-05 23.6 0.0 8.8e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EDN09997.1 - 0.00014 22.2 0.2 0.0011 19.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EDN09997.1 - 0.0016 18.9 0.1 0.0055 17.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Med7 PF05983.11 EDN09998.1 - 5.3e-62 209.3 1.7 7.4e-62 208.8 1.7 1.2 1 0 0 1 1 1 1 MED7 protein K_trans PF02705.16 EDN09999.1 - 7.5e-145 483.5 9.2 2.3e-83 280.5 1.7 2.1 1 1 1 2 2 2 2 K+ potassium transporter Cyt-b5 PF00173.28 EDN10000.1 - 1.1e-24 86.3 0.1 1.5e-24 86.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain YqzH PF14164.6 EDN10000.1 - 0.033 14.2 0.2 0.072 13.2 0.1 1.6 2 0 0 2 2 2 0 YqzH-like protein GTP_EFTU PF00009.27 EDN10001.1 - 1.4e-47 161.8 0.0 2.3e-47 161.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EDN10001.1 - 1.5e-22 79.7 0.6 2.8e-22 78.8 0.6 1.4 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.23 EDN10001.1 - 9.8e-07 28.9 0.0 2.5e-05 24.3 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EDN10001.1 - 3.4e-05 24.1 0.0 0.00012 22.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EDN10001.1 - 0.0017 18.6 0.0 0.0067 16.7 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Roc PF08477.13 EDN10001.1 - 0.0069 16.6 0.0 2.1 8.6 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDN10001.1 - 0.048 13.1 0.0 6.4 6.2 0.0 2.5 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDN10001.1 - 0.09 12.3 0.0 1.9 8.0 0.0 2.7 2 1 0 2 2 2 0 Ferrous iron transport protein B Dsh_C PF12316.8 EDN10001.1 - 7 7.0 9.8 0.4 11.1 4.2 1.8 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal HSP70 PF00012.20 EDN10002.1 - 9.1e-251 833.3 9.7 1e-250 833.1 9.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDN10002.1 - 1.2e-15 57.2 0.3 1.4e-14 53.7 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DUF5053 PF16476.5 EDN10002.1 - 0.16 11.6 0.7 38 4.0 0.0 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF5053) HEPPP_synt_1 PF07307.11 EDN10002.1 - 0.18 11.4 1.3 0.42 10.2 1.3 1.6 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Hydantoinase_A PF01968.18 EDN10002.1 - 0.34 10.1 2.9 1.1 8.5 0.0 2.8 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase Ntox15 PF15604.6 EDN10002.1 - 0.97 9.5 5.2 2.3 8.3 5.2 1.6 1 0 0 1 1 1 0 Novel toxin 15 DNase_NucA_NucB PF14040.6 EDN10003.1 - 4.9e-06 26.9 0.7 4.9e-05 23.7 0.7 2.2 1 1 0 1 1 1 1 Deoxyribonuclease NucA/NucB UCH PF00443.29 EDN10004.1 - 1.9e-53 181.6 0.0 3e-53 180.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN10004.1 - 2.5e-19 70.1 0.2 1.1e-17 64.7 0.2 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EDN10004.1 - 1.4e-05 25.6 0.0 5.1e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain VHS PF00790.19 EDN10005.1 - 2.2e-40 137.8 0.0 3.9e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 VHS domain UIM PF02809.20 EDN10005.1 - 2e-06 27.3 7.7 0.003 17.4 2.4 2.8 2 0 0 2 2 2 2 Ubiquitin interaction motif GAT PF03127.14 EDN10005.1 - 5e-05 23.5 0.1 0.00023 21.4 0.0 2.2 2 0 0 2 2 2 1 GAT domain TCO89 PF10452.9 EDN10005.1 - 0.0001 21.5 15.3 0.00012 21.2 0.0 3.5 4 0 0 4 4 4 2 TORC1 subunit TCO89 Npa1 PF11707.8 EDN10005.1 - 0.085 12.2 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal RCC1 PF00415.18 EDN10007.1 - 6.1e-23 81.2 0.7 4.7e-07 30.3 0.0 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EDN10007.1 - 1.3e-15 57.6 0.0 4.2e-07 30.2 0.0 3.1 3 0 0 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 EDN10007.1 - 3e-09 37.2 0.1 1.7e-08 34.8 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) RCC1_2 PF13540.6 EDN10007.1 - 6.1e-09 35.5 2.5 3.7e-08 33.0 0.3 3.2 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 EDN10007.1 - 1.8e-06 28.4 0.1 4.6e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN10007.1 - 1.3e-05 25.1 0.0 0.11 13.1 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EDN10007.1 - 0.0014 19.0 0.0 0.13 12.7 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EDN10007.1 - 0.014 15.7 0.1 2.2 8.7 0.1 3.5 3 0 0 3 3 3 0 Ankyrin repeats (many copies) PP28 PF10252.9 EDN10007.1 - 2.2 8.8 6.1 15 6.1 0.1 2.6 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 zf-NOSIP PF15906.5 EDN10008.1 - 0.14 12.3 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein ATG13 PF10033.9 EDN10009.1 - 4.3e-74 249.2 0.0 7.2e-74 248.5 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 NUC153 PF08159.12 EDN10013.1 - 3.6e-12 45.9 2.1 7.3e-12 44.9 2.1 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EDN10013.1 - 1.6e-05 25.5 0.3 1.5 9.9 0.0 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10013.1 - 0.0071 16.6 0.0 0.24 11.7 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Med13_C PF06333.12 EDN10014.1 - 5e-86 289.0 5.9 5e-86 289.0 5.9 2.6 3 0 0 3 3 3 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EDN10014.1 - 1e-37 130.2 3.6 5.7e-37 127.8 2.9 2.4 1 1 1 2 2 2 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EDN10014.1 - 3.2e-24 86.1 0.3 1.7e-18 67.3 0.3 4.0 3 2 1 4 4 4 2 MID domain of medPIWI Amidase PF01425.21 EDN10015.1 - 2.5e-19 69.6 0.1 8e-13 48.1 0.0 3.4 4 0 0 4 4 4 3 Amidase zf-NADH-PPase PF09297.11 EDN10016.1 - 0.023 14.3 0.1 3.5 7.4 0.3 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Ribosomal_S21e PF01249.18 EDN10016.1 - 0.12 12.4 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S21e Spc7 PF08317.11 EDN10017.1 - 0.003 16.5 16.1 0.003 16.5 16.1 5.9 2 2 4 6 6 6 2 Spc7 kinetochore protein YcgR PF07317.12 EDN10017.1 - 0.26 11.2 4.4 0.085 12.7 0.7 2.2 2 0 0 2 2 2 0 Flagellar regulator YcgR GET2 PF08690.10 EDN10018.1 - 0.19 11.4 0.0 1.5 8.4 0.0 2.0 2 0 0 2 2 2 0 GET complex subunit GET2 Cellulase PF00150.18 EDN10019.1 - 1.6e-10 40.9 0.1 1.6e-10 40.9 0.1 3.4 4 1 1 5 5 5 1 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 EDN10020.1 - 8.9e-62 208.8 0.0 1.2e-61 208.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10020.1 - 5.2e-33 114.4 0.0 7.8e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN10020.1 - 1.6e-05 24.4 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDN10020.1 - 0.00089 19.3 1.7 0.0023 17.9 0.3 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDN10020.1 - 0.0027 17.1 0.3 0.0056 16.1 0.3 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN10020.1 - 0.011 14.6 0.2 0.021 13.6 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 EDN10020.1 - 0.016 14.2 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Endonuc_Holl PF10107.9 EDN10020.1 - 0.08 12.8 0.3 0.37 10.6 0.0 1.9 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase SOG2 PF10428.9 EDN10020.1 - 2.7 7.1 8.8 3.7 6.6 8.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SNF2_N PF00176.23 EDN10022.1 - 1.7e-68 230.9 1.3 3.4e-66 223.4 1.3 3.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EDN10022.1 - 1.2e-06 28.7 0.7 2.5e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit BUD22 PF09073.10 EDN10022.1 - 0.00096 18.6 14.5 0.00096 18.6 14.5 2.4 2 0 0 2 2 2 1 BUD22 F-112 PF09645.10 EDN10022.1 - 0.023 14.8 3.5 0.45 10.6 0.0 3.5 4 0 0 4 4 4 0 F-112 protein DEAD_2 PF06733.15 EDN10022.1 - 0.065 12.9 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 DEAD_2 SIR2 PF02146.17 EDN10023.1 - 4.9e-37 127.6 0.0 5.7e-36 124.1 0.0 2.0 1 1 0 1 1 1 1 Sir2 family Pyridox_ox_2 PF12900.7 EDN10024.1 - 2e-34 118.6 0.0 3.5e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pkinase PF00069.25 EDN10025.1 - 5.4e-14 52.2 0.0 7.3e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain FR47 PF08445.10 EDN10026.1 - 5.4e-05 23.1 0.0 0.00074 19.4 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Peptidase_M24 PF00557.24 EDN10027.1 - 2.4e-51 174.4 0.0 3.3e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDN10027.1 - 3.9e-35 120.3 0.0 6.1e-35 119.6 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain RuBisCO_large PF00016.20 EDN10027.1 - 0.045 12.9 0.1 0.068 12.3 0.1 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain Dfp1_Him1_M PF08630.10 EDN10028.1 - 1.9e-40 138.0 0.1 7.1e-40 136.2 0.0 2.1 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EDN10028.1 - 7.1e-21 74.0 0.1 1.2e-20 73.3 0.1 1.4 1 0 0 1 1 1 1 DBF zinc finger PTCB-BRCT PF12738.7 EDN10028.1 - 0.012 15.6 0.0 0.058 13.4 0.0 2.2 2 0 0 2 2 2 0 twin BRCT domain DUF2855 PF11017.8 EDN10028.1 - 0.066 13.0 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Zn_clus PF00172.18 EDN10029.1 - 4.5e-07 29.9 9.5 4.5e-07 29.9 9.5 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 EDN10029.1 - 0.009 16.4 1.4 0.009 16.4 1.4 3.0 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 EDN10029.1 - 0.012 15.3 0.2 0.012 15.3 0.2 2.7 3 0 0 3 3 3 0 zinc-finger C2H2-type Pantoate_transf PF02548.15 EDN10030.1 - 2.4e-105 351.6 0.8 2.9e-105 351.4 0.8 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EDN10030.1 - 2.3e-07 30.5 0.7 4.3e-07 29.6 0.7 1.6 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 EDN10030.1 - 0.21 10.5 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) APG12 PF04110.13 EDN10031.1 - 7.4e-29 100.0 0.0 1e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EDN10031.1 - 0.092 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like Glyco_hydro_16 PF00722.21 EDN10032.1 - 2.2e-37 128.3 1.7 3.7e-37 127.5 1.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Mucin PF01456.17 EDN10032.1 - 0.74 9.8 16.0 1.3 9.0 16.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Acyl-CoA_dh_1 PF00441.24 EDN10034.1 - 3.2e-32 111.8 0.7 4.4e-32 111.3 0.1 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDN10034.1 - 2.9e-20 72.3 0.2 4.9e-20 71.5 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 EDN10034.1 - 5.7e-19 68.0 0.0 1.3e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.11 EDN10034.1 - 1.6e-05 25.2 0.0 5.9e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDN10034.1 - 0.042 14.5 1.8 0.078 13.6 0.4 2.3 2 1 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Se-cys_synth_N PF12390.8 EDN10034.1 - 0.23 11.7 0.6 25 5.2 0.0 2.6 2 0 0 2 2 2 0 Selenocysteine synthase N terminal Glyco_hydro_18 PF00704.28 EDN10035.1 - 6.6e-54 183.7 0.0 2.2e-51 175.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4849 PF16141.5 EDN10035.1 - 0.15 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 Chitin_bind_1 PF00187.19 EDN10035.1 - 0.22 12.0 4.7 0.63 10.6 4.7 1.7 1 0 0 1 1 1 0 Chitin recognition protein DDE_1 PF03184.19 EDN10036.1 - 1.1e-21 77.2 0.2 4.4e-19 68.8 0.2 2.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN10036.1 - 9.3e-11 41.6 0.0 1.8e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN10036.1 - 3.9e-07 29.7 0.1 8e-07 28.7 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_Tnp_1_7 PF13843.6 EDN10038.1 - 7.5e-14 51.8 1.7 3.3e-06 26.7 0.5 2.1 1 1 1 2 2 2 2 Transposase IS4 Choline_kinase PF01633.20 EDN10039.1 - 0.022 14.4 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EDN10039.1 - 0.037 13.6 0.0 0.088 12.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EDN10039.1 - 0.05 13.5 0.2 0.05 13.5 0.2 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDN10039.1 - 0.16 11.3 0.0 0.44 9.9 0.0 1.7 1 0 0 1 1 1 0 Protein kinase domain CDC45 PF02724.14 EDN10039.1 - 2 6.6 7.1 3.2 5.9 7.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Myb_DNA-bind_6 PF13921.6 EDN10040.1 - 0.0018 18.5 0.0 0.0044 17.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN10040.1 - 0.0078 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain RT_RNaseH PF17917.1 EDN10041.1 - 1.3e-39 134.7 0.4 1.3e-39 134.7 0.4 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN10041.1 - 1.6e-34 117.9 0.0 5.3e-34 116.3 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN10041.1 - 1.9e-28 99.5 0.3 4.4e-28 98.3 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) TSNAXIP1_N PF15739.5 EDN10041.1 - 0.12 12.8 6.0 0.64 10.4 0.3 2.9 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus NYD-SP28 PF14772.6 EDN10041.1 - 0.14 12.3 2.9 0.15 12.1 0.4 2.4 2 0 0 2 2 2 0 Sperm tail Asp_protease_2 PF13650.6 EDN10041.1 - 0.22 12.2 0.0 0.46 11.2 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease AAA_23 PF13476.6 EDN10041.1 - 0.25 11.8 7.0 8.3 6.9 0.2 2.6 2 0 0 2 2 2 0 AAA domain NDUFA12 PF05071.16 EDN10041.1 - 2.1 9.3 6.6 2.5 9.0 4.4 2.3 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Retrotrans_gag PF03732.17 EDN10041.1 - 2.4 8.5 5.9 12 6.3 2.1 3.3 2 0 0 2 2 2 0 Retrotransposon gag protein UQ_con PF00179.26 EDN10043.1 - 1.7e-28 99.1 0.1 2.3e-28 98.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LAMTOR PF15454.6 EDN10044.1 - 2.6e-16 60.0 2.5 8.8e-16 58.3 0.1 2.1 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator UPF0492 PF15744.5 EDN10044.1 - 0.15 11.2 3.2 0.37 10.0 3.2 1.5 1 1 0 1 1 1 0 Uncharacterized protein family UPF0492 DUF2011 PF09428.10 EDN10046.1 - 8.3e-29 99.7 0.8 2.3e-28 98.3 0.0 2.1 2 1 0 2 2 2 1 Fungal protein of unknown function (DUF2011) DUF1682 PF07946.14 EDN10046.1 - 0.07 12.3 7.3 0.098 11.8 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) eIF3_subunit PF08597.10 EDN10046.1 - 1.3 8.9 9.7 1.9 8.3 9.7 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Cerato-platanin PF07249.12 EDN10049.1 - 1.6e-40 137.9 0.2 2e-40 137.6 0.2 1.1 1 0 0 1 1 1 1 Cerato-platanin MFS_1 PF07690.16 EDN10050.1 - 4.7e-47 160.6 43.0 8e-47 159.9 43.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN10050.1 - 6e-15 55.0 21.2 3.2e-14 52.6 12.3 3.2 2 1 1 3 3 3 3 Sugar (and other) transporter Flavoprotein PF02441.19 EDN10051.1 - 2.1e-07 30.8 0.0 3.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 EDN10051.1 - 0.18 12.4 0.0 1.5e+02 3.1 0.0 3.8 3 2 1 4 4 4 0 Ankyrin repeats (many copies) Asparaginase_2 PF01112.18 EDN10052.1 - 2.5e-38 131.9 15.8 1.1e-18 67.3 1.2 5.0 3 2 1 4 4 4 4 Asparaginase FA_synthesis PF02504.15 EDN10052.1 - 0.12 11.4 0.3 0.2 10.7 0.3 1.2 1 0 0 1 1 1 0 Fatty acid synthesis protein Tim17 PF02466.19 EDN10053.1 - 7.7e-32 110.0 9.1 9.5e-32 109.7 9.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Orbi_VP2 PF00898.17 EDN10054.1 - 0.24 9.1 0.0 0.34 8.6 0.0 1.2 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP2 Ank_2 PF12796.7 EDN10055.1 - 4.5e-22 78.4 0.4 3.3e-07 30.8 0.0 4.1 2 2 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDN10055.1 - 6.3e-20 71.3 0.6 1.9e-08 34.7 0.0 5.6 2 2 4 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDN10055.1 - 1.7e-16 60.0 1.1 6.2e-09 35.9 0.0 4.2 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN10055.1 - 8.1e-15 54.5 7.2 0.006 17.0 0.0 6.6 7 1 0 7 7 7 3 Ankyrin repeat Ank_3 PF13606.6 EDN10055.1 - 1.6e-14 52.6 0.2 0.0036 17.7 0.0 6.1 6 1 0 7 7 7 3 Ankyrin repeat TPR_19 PF14559.6 EDN10055.1 - 0.048 14.2 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Lipase_GDSL_2 PF13472.6 EDN10056.1 - 1.3e-11 45.3 0.0 2.5e-11 44.3 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDN10056.1 - 2.6e-07 30.8 0.1 4.4e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RdRP_4 PF02123.16 EDN10056.1 - 0.032 13.1 0.0 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase TraQ PF09679.10 EDN10057.1 - 0.024 14.5 0.0 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) Fungus-induced PF10917.8 EDN10057.1 - 0.032 14.6 0.1 0.064 13.6 0.1 1.5 1 0 0 1 1 1 0 Fungus-induced protein Peptidase_M20 PF01546.28 EDN10058.1 - 6.9e-23 81.4 0.0 5.8e-21 75.1 0.0 2.3 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EDN10058.1 - 4.2e-11 43.2 11.2 0.023 15.5 0.0 6.7 5 1 0 5 5 5 3 WD domain, G-beta repeat Peptidase_M28 PF04389.17 EDN10058.1 - 4.7e-05 23.2 0.0 8.4e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 EDN10058.1 - 0.00019 21.3 0.0 0.00036 20.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 EDN10058.1 - 0.0038 17.5 0.1 13 6.2 0.0 3.8 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M42 PF05343.14 EDN10058.1 - 0.14 11.1 0.0 0.38 9.7 0.0 1.6 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase DUF747 PF05346.11 EDN10059.1 - 4.9e-102 341.7 7.7 6.9e-102 341.2 7.7 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family ECSCR PF15820.5 EDN10059.1 - 0.088 12.6 0.2 0.22 11.3 0.2 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF4834 PF16118.5 EDN10059.1 - 0.32 12.0 2.5 4.4 8.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) KCH PF16944.5 EDN10060.1 - 2.2e-99 332.3 7.3 2.7e-99 332.0 7.3 1.0 1 0 0 1 1 1 1 Fungal potassium channel Virul_fac_BrkB PF03631.15 EDN10060.1 - 0.025 14.2 5.9 0.24 11.0 1.7 2.1 2 0 0 2 2 2 0 Virulence factor BrkB MFS_1 PF07690.16 EDN10061.1 - 7.7e-06 25.1 42.9 0.0088 15.0 0.2 3.7 3 2 1 4 4 4 3 Major Facilitator Superfamily TM_helix PF05552.12 EDN10061.1 - 3.4 7.7 10.9 0.057 13.4 1.4 3.0 3 0 0 3 3 3 0 Conserved TM helix NYD-SP28 PF14772.6 EDN10062.1 - 0.0029 17.6 3.7 0.0029 17.6 3.7 6.1 5 2 0 6 6 6 1 Sperm tail AAA_13 PF13166.6 EDN10062.1 - 5.4 5.5 49.9 0.82 8.2 16.2 3.5 1 1 2 3 3 3 0 AAA domain GAT PF03127.14 EDN10062.1 - 8.4 6.8 9.8 24 5.3 0.9 3.8 3 0 0 3 3 3 0 GAT domain DUF21 PF01595.20 EDN10063.1 - 1.3e-30 106.4 0.0 2.1e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EDN10063.1 - 4.4e-05 23.9 0.3 0.066 13.7 0.0 3.0 2 0 0 2 2 2 2 CBS domain DUF1772 PF08592.11 EDN10063.1 - 0.083 13.2 0.2 0.2 12.0 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Holin_BhlA PF10960.8 EDN10063.1 - 0.26 11.3 0.4 11 6.1 0.0 2.4 2 0 0 2 2 2 0 BhlA holin family zf-C2H2_2 PF12756.7 EDN10064.1 - 3.9e-38 129.8 13.0 1.7e-29 102.1 5.3 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EDN10064.1 - 1.1e-10 41.5 4.1 1e-07 32.0 1.8 3.8 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDN10064.1 - 7.6e-08 32.5 8.3 4.1e-06 27.0 1.6 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDN10064.1 - 0.0045 17.7 21.4 0.1 13.5 0.2 5.2 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN10064.1 - 0.022 15.2 0.6 0.022 15.2 0.6 5.1 5 0 0 5 5 5 0 Zinc finger, C2H2 type DUF2024 PF09630.10 EDN10064.1 - 0.026 14.4 2.9 0.35 10.8 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) ALMS_motif PF15309.6 EDN10064.1 - 0.035 14.6 1.0 0.075 13.5 1.0 1.6 1 0 0 1 1 1 0 ALMS motif Cytochrome-c551 PF10643.9 EDN10064.1 - 0.39 10.3 1.6 20 4.7 0.1 2.9 3 0 0 3 3 3 0 Photosystem P840 reaction-centre cytochrome c-551 HECT PF00632.25 EDN10065.1 - 5.6e-71 239.5 0.0 1.6e-70 238.0 0.0 1.7 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EDN10065.1 - 3.8e-22 78.3 1.1 9e-22 77.1 1.1 1.7 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A His_Phos_1 PF00300.22 EDN10066.1 - 1e-17 64.4 0.1 2.1e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Rrn6 PF10214.9 EDN10067.1 - 0.018 13.6 4.7 0.02 13.4 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1357 PF07094.11 EDN10067.1 - 0.19 11.7 6.2 0.3 11.1 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1357) DUF4407 PF14362.6 EDN10067.1 - 0.26 10.6 6.6 0.38 10.0 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1682 PF07946.14 EDN10067.1 - 0.78 8.9 8.1 1.1 8.4 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF4551 PF15087.6 EDN10067.1 - 7.1 5.3 8.4 10 4.8 8.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Pyr_redox_2 PF07992.14 EDN10068.1 - 9.5e-14 51.3 0.0 3.8e-13 49.3 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN10068.1 - 0.0046 16.3 0.0 0.19 11.0 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDN10068.1 - 0.0059 15.9 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EDN10068.1 - 0.0092 15.2 0.1 0.02 14.1 0.1 1.5 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EDN10068.1 - 0.02 13.6 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 EDN10068.1 - 0.049 12.7 0.7 0.084 11.9 0.3 1.6 2 1 0 2 2 2 0 FAD binding domain K_oxygenase PF13434.6 EDN10068.1 - 0.049 12.8 0.1 2.5 7.1 0.0 2.2 1 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EDN10068.1 - 0.057 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EDN10068.1 - 0.16 11.0 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 EDN10068.1 - 0.16 11.5 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Sgf11_N PF18519.1 EDN10068.1 - 1.1 8.9 2.5 17 5.1 0.1 2.7 2 1 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain DDE_1 PF03184.19 EDN10071.1 - 8e-30 103.8 0.0 3.5e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN10071.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_C2 PF00648.21 EDN10072.1 - 5.9e-59 199.5 2.4 3.3e-57 193.8 1.3 2.9 2 1 0 2 2 2 1 Calpain family cysteine protease Pkinase PF00069.25 EDN10073.1 - 2e-71 240.4 0.0 2.9e-71 239.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10073.1 - 5.3e-31 107.8 0.0 6.8e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN10073.1 - 0.00031 20.2 0.0 0.00059 19.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDN10073.1 - 0.0005 19.1 0.1 0.014 14.4 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EDN10073.1 - 0.0049 16.8 0.1 0.011 15.7 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDN10073.1 - 0.01 14.9 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EDN10073.1 - 0.076 12.4 0.0 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family 2OG-FeII_Oxy_2 PF13532.6 EDN10074.1 - 9e-21 75.0 0.0 1.6e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 EDN10074.1 - 3.5e-18 65.9 0.0 1.9e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10074.1 - 4.9e-08 32.6 0.5 0.0035 16.7 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EDN10074.1 - 0.0044 17.0 0.2 0.014 15.3 0.2 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDN10074.1 - 0.048 13.0 0.4 7.9 5.7 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EDN10074.1 - 0.22 10.8 1.3 0.35 10.2 0.3 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Amidase PF01425.21 EDN10075.1 - 1.6e-62 212.0 0.1 3.5e-45 154.8 0.2 2.1 1 1 1 2 2 2 2 Amidase HNH_2 PF13391.6 EDN10076.1 - 1.7e-07 31.2 0.1 3.4e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 HNH endonuclease TolA_bind_tri PF16331.5 EDN10077.1 - 0.32 11.1 3.4 1.5 8.9 1.3 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation PRKG1_interact PF15898.5 EDN10077.1 - 0.47 11.4 2.7 0.56 11.1 0.1 2.5 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF4200 PF13863.6 EDN10077.1 - 0.96 9.9 3.7 2.5 8.5 3.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) BMFP PF04380.13 EDN10077.1 - 1.1 9.7 3.3 9.9 6.7 0.6 2.5 2 0 0 2 2 2 0 Membrane fusogenic activity tRNA-synt_1b PF00579.25 EDN10079.1 - 2.1e-19 69.9 0.0 5.4e-19 68.6 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) RRM_1 PF00076.22 EDN10080.1 - 6.8e-17 61.1 0.0 1.3e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 6PGD PF00393.19 EDN10081.1 - 6.2e-128 426.2 0.0 7.8e-128 425.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EDN10081.1 - 9e-50 168.9 0.0 1.6e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Ub-Mut7C PF14451.6 EDN10081.1 - 0.066 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Mut7-C ubiquitin AD PF09793.9 EDN10082.1 - 5.4e-27 93.8 0.0 1.1e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain Macoilin PF09726.9 EDN10082.1 - 3.2 6.2 6.8 4 5.9 6.8 1.2 1 0 0 1 1 1 0 Macoilin family P_C PF06640.11 EDN10082.1 - 4.6 7.3 9.1 46 4.1 6.3 2.4 2 0 0 2 2 2 0 P protein C-terminus Glyco_hydro_18 PF00704.28 EDN10083.1 - 3.5e-82 276.6 1.3 4.1e-82 276.4 1.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 TPT PF03151.16 EDN10085.1 - 2.8e-16 59.7 9.1 3.5e-16 59.4 9.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDN10085.1 - 4.8e-09 36.5 25.2 5.9e-05 23.3 1.5 2.3 2 0 0 2 2 2 2 EamA-like transporter family DUF1509 PF07420.11 EDN10085.1 - 0.051 12.5 0.8 0.074 12.0 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) DUF4346 PF14251.6 EDN10086.1 - 0.044 13.8 0.0 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4346) DNA_pol_phi PF04931.13 EDN10087.1 - 1.4e-171 572.4 13.4 2e-171 571.9 13.4 1.1 1 0 0 1 1 1 1 DNA polymerase phi DUF4724 PF15852.5 EDN10087.1 - 4.1 7.9 7.8 3.4 8.2 0.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4724) AP_endonuc_2 PF01261.24 EDN10088.1 - 2.4e-23 82.7 0.0 3.4e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DLH PF01738.18 EDN10089.1 - 8.7e-15 54.9 0.0 1.1e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EDN10089.1 - 0.074 12.5 0.4 0.34 10.3 0.0 2.0 1 1 1 2 2 2 0 Prolyl oligopeptidase family Mad3_BUB1_I PF08311.12 EDN10090.1 - 3e-44 150.0 0.0 4e-44 149.6 0.0 1.2 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.5 EDN10090.1 - 0.2 11.8 0.0 0.31 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein DUF5585 PF17823.1 EDN10090.1 - 0.26 10.2 3.1 0.36 9.7 3.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Pkinase PF00069.25 EDN10091.1 - 4.8e-07 29.4 0.0 8.4e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10091.1 - 0.076 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Peptidase_C15 PF01470.17 EDN10093.1 - 3.5e-06 27.3 0.9 0.017 15.3 0.0 3.5 3 1 0 3 3 3 2 Pyroglutamyl peptidase F-box-like PF12937.7 EDN10094.1 - 0.0024 17.7 0.2 0.0062 16.4 0.2 1.7 1 0 0 1 1 1 1 F-box-like UBM PF14377.6 EDN10094.1 - 0.0066 15.9 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin binding region F-box PF00646.33 EDN10094.1 - 0.023 14.5 0.0 0.074 13.0 0.0 1.8 1 0 0 1 1 1 0 F-box domain DUF1247 PF06851.11 EDN10094.1 - 0.025 14.5 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) PRANC PF09372.10 EDN10094.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 PRANC domain Rhodanese PF00581.20 EDN10095.1 - 3.5e-14 53.2 0.1 1e-13 51.7 0.1 1.7 1 0 0 1 1 1 1 Rhodanese-like domain LNS2 PF08235.13 EDN10095.1 - 0.069 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Sld5 PF05916.11 EDN10096.1 - 2.1e-09 37.8 0.3 3.3e-09 37.2 0.3 1.5 1 1 0 1 1 1 1 GINS complex protein SLD5_C PF16922.5 EDN10096.1 - 2.1e-08 34.2 1.0 3.8e-08 33.4 1.0 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus SPX PF03105.19 EDN10096.1 - 0.0004 20.4 2.7 0.00048 20.1 2.7 1.2 1 0 0 1 1 1 1 SPX domain Cullin PF00888.22 EDN10097.1 - 9.1e-202 672.0 6.4 1.4e-201 671.4 6.4 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDN10097.1 - 2.3e-27 94.8 2.8 6.6e-27 93.3 0.4 2.9 3 0 0 3 3 3 1 Cullin protein neddylation domain Rrf2 PF02082.20 EDN10097.1 - 0.035 14.5 0.2 0.17 12.2 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator HTH_IclR PF09339.10 EDN10097.1 - 0.047 13.5 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain TrmB PF01978.19 EDN10097.1 - 0.086 12.7 0.1 24 4.9 0.0 2.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB TSP_NTD PF17804.1 EDN10097.1 - 1.6 9.0 5.8 1.1 9.4 2.2 2.4 2 0 0 2 2 2 0 Tail specific protease N-terminal domain zf-DNL PF05180.12 EDN10098.1 - 8.4e-06 25.6 0.1 1.5e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 DNL zinc finger DRIM PF07539.12 EDN10099.1 - 2.8e-114 382.7 15.1 3.3e-75 253.7 0.1 4.6 4 2 2 6 6 6 2 Down-regulated in metastasis HEAT PF02985.22 EDN10099.1 - 0.013 15.7 0.7 1.3e+02 3.3 0.0 6.3 6 0 0 6 6 6 0 HEAT repeat Katanin_con80 PF13925.6 EDN10099.1 - 0.064 13.3 0.6 1.4 8.9 0.1 3.3 2 0 0 2 2 2 0 con80 domain of Katanin Op_neuropeptide PF08035.11 EDN10099.1 - 0.16 11.9 0.2 0.7 9.8 0.2 2.2 1 0 0 1 1 1 0 Opioids neuropeptide MIF PF01187.18 EDN10100.1 - 1.5e-16 60.7 0.0 1.6e-16 60.6 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 EDN10100.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Tautomerase enzyme CwfJ_C_1 PF04677.15 EDN10101.1 - 1.4e-25 89.5 0.0 3.1e-25 88.4 0.0 1.5 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EDN10101.1 - 1.6e-15 57.7 1.0 3.5e-15 56.7 1.0 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Metallophos PF00149.28 EDN10101.1 - 0.0084 16.6 0.0 0.017 15.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF829 PF05705.14 EDN10102.1 - 6.2e-39 134.3 0.0 7.2e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) LSR PF05624.14 EDN10103.1 - 1.2 9.2 31.3 2 8.5 31.3 1.3 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) Corona_S2 PF01601.16 EDN10103.1 - 1.4 7.3 19.5 2 6.8 19.5 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein RCR PF12273.8 EDN10104.1 - 1.5e-17 64.4 15.5 1.8e-17 64.0 15.5 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SARAF PF06682.12 EDN10104.1 - 0.0037 17.0 0.2 0.0047 16.6 0.2 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis NnrU PF07298.11 EDN10104.1 - 0.064 12.8 0.0 0.09 12.3 0.0 1.1 1 0 0 1 1 1 0 NnrU protein Herpes_UL73 PF03554.13 EDN10104.1 - 9.2 6.4 6.2 14 5.8 2.2 2.2 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein Arf PF00025.21 EDN10105.1 - 6.1e-43 146.3 0.0 7.3e-43 146.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EDN10105.1 - 5.1e-19 68.5 0.0 5.8e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN10105.1 - 9.5e-16 58.1 0.0 1.4e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDN10105.1 - 8.5e-09 35.5 0.0 1.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDN10105.1 - 9.5e-08 31.7 0.0 1.3e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDN10105.1 - 4.4e-07 29.5 0.0 5.2e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDN10105.1 - 0.00024 20.4 0.0 0.0016 17.7 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 EDN10105.1 - 0.0071 16.4 0.1 0.043 13.9 0.1 1.9 1 1 1 2 2 2 1 Dynamin family MMR_HSR1_Xtn PF16897.5 EDN10105.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EDN10105.1 - 0.025 14.1 0.1 0.12 11.9 0.0 1.9 2 1 0 2 2 2 0 Ferrous iron transport protein B DUF1979 PF09322.10 EDN10105.1 - 0.052 13.5 0.7 2 8.4 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) RsgA_GTPase PF03193.16 EDN10105.1 - 0.056 13.4 0.0 8.4 6.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase RNA_pol_Rpb2_6 PF00562.28 EDN10106.1 - 9.6e-116 387.0 0.0 1.3e-115 386.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDN10106.1 - 2e-38 132.0 0.0 3.2e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDN10106.1 - 5.4e-26 91.4 0.0 9.5e-26 90.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 EDN10106.1 - 8.4e-26 89.8 0.1 3.6e-25 87.7 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 EDN10106.1 - 4.7e-15 55.8 0.0 3.1e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EDN10106.1 - 0.00012 22.2 0.0 0.00032 20.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 Proteasome PF00227.26 EDN10107.1 - 7.9e-47 159.2 0.3 9.6e-47 158.9 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF1685 PF07939.11 EDN10107.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1685) Pil1 PF13805.6 EDN10108.1 - 1.5e-95 319.7 4.6 1.9e-95 319.4 4.6 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Bac_DnaA PF00308.18 EDN10108.1 - 0.033 14.0 0.8 0.051 13.4 0.8 1.2 1 0 0 1 1 1 0 Bacterial dnaA protein PaaX_C PF08223.11 EDN10108.1 - 0.073 13.4 0.2 0.45 10.8 0.1 2.2 2 0 0 2 2 2 0 PaaX-like protein C-terminal domain FAM178 PF14816.6 EDN10108.1 - 0.097 11.6 2.5 0.15 11.0 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function, FAM178 SWI-SNF_Ssr4 PF08549.10 EDN10109.1 - 1.6e-158 529.6 22.2 3.7e-114 382.9 8.8 2.0 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1750) TBPIP PF07106.13 EDN10109.1 - 0.11 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain Ppx-GppA PF02541.16 EDN10110.1 - 2.9e-46 158.2 0.0 4.3e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Thi4 PF01946.17 EDN10112.1 - 3.5e-109 363.5 0.0 4.3e-109 363.2 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EDN10112.1 - 8.8e-07 28.8 0.3 1.5e-06 28.0 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDN10112.1 - 4.7e-05 23.5 1.1 0.00012 22.2 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EDN10112.1 - 0.00027 20.1 0.7 0.00068 18.8 0.4 1.8 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EDN10112.1 - 0.0015 18.5 0.2 0.011 15.8 0.1 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EDN10112.1 - 0.0032 16.7 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDN10112.1 - 0.047 12.8 0.5 0.15 11.1 0.4 1.8 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.19 EDN10112.1 - 0.085 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 EDN10112.1 - 0.11 11.3 0.2 0.17 10.7 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EDN10112.1 - 0.16 11.2 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDN10112.1 - 0.22 10.2 0.4 0.31 9.7 0.4 1.2 1 0 0 1 1 1 0 HI0933-like protein Exo_endo_phos PF03372.23 EDN10113.1 - 1.1e-13 51.2 0.0 1.7e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 EDN10114.1 - 2.9e-27 94.4 4.4 2e-06 28.4 0.0 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10114.1 - 6.6e-10 39.2 0.0 0.0059 16.9 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDN10114.1 - 0.00012 21.5 0.0 0.00021 20.7 0.0 1.4 1 1 1 2 2 2 1 WD40-like domain eIF2A PF08662.11 EDN10114.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDN10114.1 - 0.0013 17.5 0.3 0.17 10.5 0.0 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Frtz PF11768.8 EDN10114.1 - 0.01 14.2 0.0 0.014 13.8 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 EDN10114.1 - 0.019 14.0 0.0 0.14 11.1 0.0 1.9 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain DUF1513 PF07433.11 EDN10114.1 - 0.076 12.1 0.0 0.28 10.2 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) Ge1_WD40 PF16529.5 EDN10114.1 - 0.26 10.2 0.1 70 2.2 0.0 2.7 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyco_hydro_cc PF11790.8 EDN10115.1 - 2.4e-59 200.8 0.0 2.9e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core RED_N PF07808.13 EDN10116.1 - 1.9e-09 37.5 1.4 5.9e-09 35.9 1.4 1.9 1 0 0 1 1 1 1 RED-like protein N-terminal region zf-UBR PF02207.20 EDN10117.1 - 2.1e-17 63.0 15.8 2.1e-17 63.0 15.8 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EDN10117.1 - 3.5e-06 26.7 0.1 8.5e-06 25.5 0.1 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS UCR_UQCRX_QCR9 PF05365.12 EDN10118.1 - 9.9e-28 95.9 0.7 1.1e-27 95.7 0.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Mago-bind PF09282.10 EDN10119.1 - 1.4e-14 53.6 1.5 2.9e-14 52.6 1.5 1.5 1 0 0 1 1 1 1 Mago binding RR_TM4-6 PF06459.12 EDN10119.1 - 6.2 6.6 8.9 7.7 6.3 8.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Amino_oxidase PF01593.24 EDN10120.1 - 6.1e-32 111.5 0.1 1e-31 110.8 0.1 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDN10120.1 - 6.5e-14 51.9 0.1 1.9e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDN10120.1 - 1.9e-07 31.0 0.1 1.1e-06 28.6 0.0 2.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN10120.1 - 2e-06 27.2 0.0 0.0015 17.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDN10120.1 - 0.00046 19.0 0.1 0.0044 15.8 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EDN10120.1 - 0.0009 19.3 0.0 0.0079 16.2 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDN10120.1 - 0.0013 19.3 0.1 0.36 11.4 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDN10120.1 - 0.0068 15.7 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EDN10120.1 - 0.0072 15.5 0.0 0.018 14.1 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain ApbA PF02558.16 EDN10120.1 - 0.02 14.5 0.5 0.78 9.4 0.1 2.8 2 1 1 3 3 3 0 Ketopantoate reductase PanE/ApbA FMO-like PF00743.19 EDN10120.1 - 0.055 11.9 0.0 0.078 11.4 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 EDN10120.1 - 0.086 12.1 0.1 0.77 9.0 0.0 2.2 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain zf-CCCH_2 PF14608.6 EDN10121.1 - 1.3e-09 38.2 54.4 8.8e-06 26.0 10.7 5.8 5 2 1 6 6 6 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 EDN10121.1 - 0.008 16.5 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Glyco_hydro_20 PF00728.22 EDN10122.1 - 7.6e-64 216.3 0.0 8.8e-64 216.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain p450 PF00067.22 EDN10124.1 - 1.4e-24 86.7 0.5 2.7e-14 52.8 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 Annexin PF00191.20 EDN10125.1 - 5e-32 109.8 1.4 2.6e-10 40.2 0.0 4.5 4 1 0 4 4 4 4 Annexin Acetyltransf_11 PF13720.6 EDN10125.1 - 0.0029 18.0 0.2 0.42 11.1 0.0 3.1 3 1 1 4 4 4 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Glyco_hydro_16 PF00722.21 EDN10126.1 - 1.6e-40 138.4 1.0 2.4e-40 137.9 1.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 tRNA-synt_1b PF00579.25 EDN10128.1 - 3.2e-63 213.8 0.0 3.9e-63 213.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Fer4_5 PF12801.7 EDN10128.1 - 0.054 13.4 0.6 0.1 12.6 0.6 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain RNA_pol_A_bac PF01000.26 EDN10129.1 - 8.4e-32 109.9 0.0 1.5e-31 109.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDN10129.1 - 6.5e-16 57.5 0.0 1e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain FTA2 PF13095.6 EDN10130.1 - 2.8e-05 23.8 0.0 3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 GSK-3_bind PF05350.12 EDN10130.1 - 0.04 13.3 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding NUDIX PF00293.28 EDN10131.1 - 1.3e-19 70.6 0.3 1.5e-19 70.4 0.3 1.0 1 0 0 1 1 1 1 NUDIX domain ATE_C PF04377.15 EDN10132.1 - 3.7e-30 105.3 2.3 5.5e-30 104.7 2.3 1.6 1 1 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EDN10132.1 - 2.3e-22 79.2 0.4 4.9e-22 78.1 0.4 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus ACC_epsilon PF13822.6 EDN10134.1 - 0.012 16.3 0.1 0.019 15.6 0.0 1.4 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Conotoxin PF02950.17 EDN10134.1 - 1.5 9.9 9.2 0.36 11.9 4.1 1.9 1 1 1 2 2 2 0 Conotoxin Cytochrom_C PF00034.21 EDN10135.1 - 1e-12 49.0 0.0 1.4e-12 48.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EDN10135.1 - 3.4e-08 33.7 1.0 1.3e-07 31.8 1.0 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EDN10135.1 - 0.0018 18.0 0.6 0.0065 16.2 0.6 2.0 1 1 0 1 1 1 1 Cytochrome c-550 domain RNase_PH PF01138.21 EDN10137.1 - 2e-06 28.4 0.1 4.9e-05 23.8 0.0 2.6 2 1 1 3 3 3 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDN10137.1 - 0.056 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Pkinase PF00069.25 EDN10139.1 - 1.1e-58 198.7 0.0 1.6e-58 198.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10139.1 - 6.3e-36 124.0 0.0 9.4e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN10139.1 - 0.00088 18.3 0.0 0.0013 17.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EDN10139.1 - 0.045 12.7 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RICH PF05062.12 EDN10140.1 - 0.054 13.9 4.9 0.27 11.6 1.1 2.0 2 0 0 2 2 2 0 RICH domain Stc1 PF12898.7 EDN10141.1 - 4.7e-18 65.5 5.3 8e-18 64.8 5.3 1.3 1 0 0 1 1 1 1 Stc1 domain Stn1 PF10451.9 EDN10142.1 - 1.1e-15 57.3 0.1 2.3e-09 36.6 0.0 2.2 2 0 0 2 2 2 2 Telomere regulation protein Stn1 Inv-AAD PF18785.1 EDN10144.1 - 3.5e-36 123.9 0.1 2.6e-17 62.9 0.2 3.1 2 1 0 2 2 2 2 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EDN10144.1 - 1.5e-09 37.6 0.0 3e-08 33.4 0.0 2.4 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EDN10144.1 - 0.13 12.2 0.0 0.42 10.5 0.0 1.7 2 0 0 2 2 2 0 APOBEC-like N-terminal domain DnaJ PF00226.31 EDN10145.1 - 4.3e-24 84.4 1.9 9.6e-24 83.3 1.9 1.7 1 0 0 1 1 1 1 DnaJ domain Usp PF00582.26 EDN10146.1 - 3.7e-21 76.1 3.4 1.4e-13 51.6 0.2 2.8 3 0 0 3 3 3 2 Universal stress protein family CDC45 PF02724.14 EDN10146.1 - 1.9 6.7 6.5 2.8 6.1 6.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S10 PF00450.22 EDN10147.1 - 3e-77 260.8 0.0 5.6e-77 259.9 0.0 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase DUF3945 PF13101.6 EDN10147.1 - 0.18 11.5 0.2 0.47 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) ATP-synt_ab PF00006.25 EDN10148.1 - 1.8e-68 230.4 0.0 2.3e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDN10148.1 - 3e-11 43.7 0.3 5.8e-11 42.7 0.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain GFO_IDH_MocA PF01408.22 EDN10149.1 - 3.5e-12 47.2 0.1 7.8e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDN10149.1 - 1.3e-08 34.9 0.0 2.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Sacchrp_dh_NADP PF03435.18 EDN10149.1 - 0.056 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PALP PF00291.25 EDN10150.1 - 5.2e-49 167.2 1.9 7.4e-49 166.7 1.9 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Trp_syntA PF00290.20 EDN10150.1 - 2.4e-36 124.9 0.0 4.6e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain Peptidase_A21 PF03566.13 EDN10154.1 - 2.2 6.4 4.9 2.3 6.4 4.9 1.1 1 0 0 1 1 1 0 Peptidase family A21 ADH_zinc_N PF00107.26 EDN10156.1 - 6.3e-22 77.9 0.1 9.8e-22 77.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDN10156.1 - 3.4e-09 37.9 0.0 7e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN10156.1 - 0.00061 19.7 0.0 0.0015 18.4 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain YjeF_N PF03853.15 EDN10156.1 - 0.057 13.3 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus adh_short PF00106.25 EDN10156.1 - 0.058 12.8 0.2 0.13 11.7 0.2 1.6 1 0 0 1 1 1 0 short chain dehydrogenase MAPEG PF01124.18 EDN10157.1 - 8.7e-20 70.9 0.8 9.8e-20 70.8 0.8 1.0 1 0 0 1 1 1 1 MAPEG family DUF2298 PF10060.9 EDN10157.1 - 0.0025 16.6 0.6 0.0035 16.1 0.3 1.3 1 1 0 1 1 1 1 Uncharacterized membrane protein (DUF2298) GYF PF02213.16 EDN10158.1 - 1.6e-16 59.7 0.4 3.9e-16 58.4 0.4 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EDN10158.1 - 0.15 11.9 1.2 0.44 10.4 0.3 2.3 2 0 0 2 2 2 0 GYF domain 2 Aminotran_5 PF00266.19 EDN10159.1 - 5.4e-24 84.8 0.0 7.5e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EDN10159.1 - 5e-06 25.9 0.0 6.6e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDN10159.1 - 0.0021 16.7 0.0 0.0031 16.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EDN10159.1 - 0.075 12.3 0.1 0.14 11.5 0.1 1.4 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DSBA PF01323.20 EDN10160.1 - 2.3e-14 53.6 0.0 2.7e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 EDN10160.1 - 0.0025 17.8 0.1 0.0042 17.1 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EDN10160.1 - 0.16 12.1 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin DUF3382 PF11862.8 EDN10161.1 - 8.9 6.7 11.2 1.2 9.5 0.1 3.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3382) Spc24 PF08286.11 EDN10162.1 - 2.8e-36 124.0 1.3 2.9e-35 120.7 0.1 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 DUF4472 PF14739.6 EDN10162.1 - 0.11 13.2 2.4 0.14 12.9 0.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) CLZ PF16526.5 EDN10162.1 - 0.5 10.8 7.8 0.34 11.3 1.8 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels APG6_N PF17675.1 EDN10162.1 - 1.8 9.1 7.2 2.7 8.5 7.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Nup54 PF13874.6 EDN10162.1 - 2.9 8.0 6.6 21 5.2 6.6 2.0 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Fis1_TPR_C PF14853.6 EDN10163.1 - 3.7e-25 87.8 0.9 6.3e-25 87.0 0.9 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EDN10163.1 - 1.2e-16 60.1 0.1 2.1e-16 59.3 0.1 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat zf-RING_2 PF13639.6 EDN10163.1 - 4.6e-12 46.1 8.6 7.6e-12 45.4 8.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDN10163.1 - 1.7e-09 37.3 1.7 3.1e-09 36.4 1.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDN10163.1 - 2e-08 33.9 7.8 3.4e-08 33.2 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDN10163.1 - 3.6e-06 26.7 3.1 6.1e-06 26.0 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN10163.1 - 1.1e-05 25.2 5.8 1.8e-05 24.5 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDN10163.1 - 1.3e-05 25.3 11.8 3.9e-05 23.9 11.8 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDN10163.1 - 1.4e-05 25.0 4.1 2.4e-05 24.2 4.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDN10163.1 - 4e-05 23.6 3.9 8.7e-05 22.5 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDN10163.1 - 0.001 18.9 6.3 0.0018 18.1 6.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EDN10163.1 - 0.001 19.0 2.7 0.0021 18.1 2.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_2 PF07719.17 EDN10163.1 - 0.024 14.7 1.2 0.05 13.7 1.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-HC5HC2H_2 PF13832.6 EDN10163.1 - 0.049 13.8 0.0 0.095 12.9 0.0 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDN10163.1 - 0.12 12.7 0.5 0.25 11.6 0.5 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain Vps39_2 PF10367.9 EDN10163.1 - 0.14 12.6 0.0 2.9 8.4 0.0 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 PHD PF00628.29 EDN10163.1 - 0.27 11.2 5.3 0.44 10.5 5.3 1.4 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 EDN10163.1 - 0.3 10.7 5.1 0.5 10.0 5.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EDN10163.1 - 0.82 9.5 3.4 1.4 8.7 3.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDN10163.1 - 1.1 9.5 5.1 4.8 7.4 5.1 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EDN10163.1 - 1.2 9.3 7.1 2.3 8.4 7.1 1.4 1 0 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 EDN10163.1 - 7.5 6.7 6.4 14 5.8 6.4 1.5 1 0 0 1 1 1 0 Zinc-finger DUF3431 PF11913.8 EDN10164.1 - 3.4e-85 285.2 0.4 5.3e-85 284.6 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3431) DUF2034 PF10356.9 EDN10166.1 - 1.1e-34 119.5 0.0 1.4e-18 67.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EDN10166.1 - 3.1e-07 30.4 0.0 7.6e-07 29.2 0.0 1.6 2 0 0 2 2 2 1 Restriction endonuclease Med21 PF11221.8 EDN10167.1 - 3.5e-55 186.2 15.7 4.2e-53 179.5 15.7 2.0 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Spore_III_AB PF09548.10 EDN10167.1 - 0.025 14.7 0.4 0.042 13.9 0.4 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) PMC2NT PF08066.12 EDN10167.1 - 0.097 13.4 0.1 0.31 11.8 0.0 1.9 2 0 0 2 2 2 0 PMC2NT (NUC016) domain Med9 PF07544.13 EDN10167.1 - 0.37 10.9 3.6 0.48 10.5 1.3 2.4 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 ATG16 PF08614.11 EDN10167.1 - 3.6 7.8 12.6 8.8 6.5 12.6 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) ATP-synt_E PF05680.12 EDN10167.1 - 8.4 6.8 7.5 0.43 11.0 1.6 1.9 2 1 1 3 3 3 0 ATP synthase E chain SNF2_N PF00176.23 EDN10168.1 - 1.9e-60 204.5 0.1 3.1e-60 203.8 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDN10168.1 - 3.5e-12 46.6 0.0 1.2e-10 41.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN10168.1 - 1.7e-05 24.7 0.1 7.1e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN10168.1 - 0.0023 18.0 0.0 0.0072 16.3 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 EDN10168.1 - 0.035 14.1 2.6 0.066 13.2 2.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EDN10168.1 - 0.61 10.0 2.7 1.5 8.8 2.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PI3_PI4_kinase PF00454.27 EDN10169.1 - 2.6e-44 151.9 0.0 4.2e-44 151.2 0.0 1.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GATA PF00320.27 EDN10170.1 - 8.5e-16 57.3 2.7 2.2e-15 56.0 2.7 1.8 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDN10170.1 - 0.0068 15.9 0.7 0.014 14.9 0.7 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Serinc PF03348.15 EDN10173.1 - 6.9e-160 532.7 10.1 8.3e-160 532.4 10.1 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DNA_mis_repair PF01119.19 EDN10174.1 - 3.4e-19 68.7 0.0 6e-17 61.4 0.0 3.3 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 EDN10174.1 - 4.5e-19 68.7 0.9 3.4e-17 62.6 0.9 3.0 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EDN10174.1 - 7.4e-11 42.0 0.3 2.8e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDN10174.1 - 1e-06 29.2 1.1 6.6e-06 26.6 0.0 2.9 3 1 1 4 4 4 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GCN5L1 PF06320.13 EDN10175.1 - 1.3e-17 64.0 5.9 1.6e-17 63.7 5.9 1.1 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) DUF3552 PF12072.8 EDN10175.1 - 0.02 14.3 10.7 0.039 13.4 10.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) BST2 PF16716.5 EDN10175.1 - 0.033 14.8 11.1 0.67 10.6 7.5 2.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DASH_Dad2 PF08654.10 EDN10175.1 - 0.078 13.4 5.1 0.042 14.3 2.3 1.9 1 1 1 2 2 2 0 DASH complex subunit Dad2 DUF16 PF01519.16 EDN10175.1 - 0.36 11.4 6.0 0.22 12.0 3.8 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 UPF0515 PF15135.6 EDN10175.1 - 0.38 10.1 1.6 0.43 9.9 1.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 DUF2098 PF09871.9 EDN10175.1 - 0.4 11.1 10.0 0.73 10.2 0.4 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) Pro-NT_NN PF07421.11 EDN10175.1 - 0.43 10.8 4.4 0.51 10.6 4.4 1.3 1 1 0 1 1 1 0 Neurotensin/neuromedin N precursor DUF848 PF05852.11 EDN10175.1 - 0.44 10.7 6.6 0.41 10.7 5.5 1.5 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FapA PF03961.13 EDN10175.1 - 0.46 9.0 6.0 0.53 8.8 6.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-C4H2 PF10146.9 EDN10175.1 - 0.71 10.1 6.5 1.3 9.3 6.5 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF2951 PF11166.8 EDN10175.1 - 4.4 7.6 9.2 96 3.3 9.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) CPSase_L_D2 PF02786.17 EDN10176.1 - 1.5e-51 174.9 0.0 2.2e-51 174.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EDN10176.1 - 7.5e-31 106.9 0.0 1.4e-30 106.0 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDN10176.1 - 5.7e-30 103.6 0.0 2.4e-29 101.6 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EDN10176.1 - 2.7e-12 46.3 2.3 6.4e-12 45.1 0.4 2.6 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EDN10176.1 - 7.7e-10 38.6 0.0 1.5e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDN10176.1 - 2.1e-06 27.4 0.0 3.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDN10176.1 - 9.8e-05 22.4 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 EDN10176.1 - 0.0029 16.9 0.1 0.005 16.1 0.1 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 EDN10176.1 - 0.0048 16.7 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like RnfC_N PF13375.6 EDN10176.1 - 0.011 15.6 0.0 0.031 14.2 0.0 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATPgrasp_ST PF14397.6 EDN10176.1 - 0.026 13.8 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF2118 PF09891.9 EDN10176.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) Carboxyl_trans PF01039.22 EDN10177.1 - 1.3e-53 182.4 0.0 1.8e-44 152.3 0.0 2.1 1 1 1 2 2 2 2 Carboxyl transferase domain BCDHK_Adom3 PF10436.9 EDN10178.1 - 2.6e-45 154.1 0.1 3.5e-45 153.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDN10178.1 - 4.9e-10 39.9 0.0 1.9e-09 38.0 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3425 PF11905.8 EDN10179.1 - 7.5e-12 45.3 2.6 2.5e-11 43.6 2.6 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) RIBIOP_C PF04950.12 EDN10181.1 - 6.5e-87 291.6 0.1 6.5e-87 291.6 0.1 1.8 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDN10181.1 - 6.3e-29 99.9 0.0 1.9e-28 98.4 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 EDN10181.1 - 2.3e-05 24.7 0.0 6.7e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EDN10181.1 - 6.4e-05 22.6 0.0 0.012 15.2 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EDN10181.1 - 0.0002 21.8 0.0 0.00054 20.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN10181.1 - 0.00036 20.9 0.0 0.00094 19.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EDN10181.1 - 0.00078 19.6 0.0 0.00078 19.6 0.0 2.4 3 0 0 3 3 1 1 AAA domain MMR_HSR1 PF01926.23 EDN10181.1 - 0.0022 18.0 0.1 0.0068 16.5 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.22 EDN10181.1 - 0.0034 16.6 0.0 0.007 15.6 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 EDN10181.1 - 0.0039 17.5 0.0 0.0082 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EDN10181.1 - 0.0073 16.1 0.1 0.068 12.9 0.1 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDN10181.1 - 0.009 15.9 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 EDN10181.1 - 0.0095 16.5 0.1 0.034 14.7 0.1 2.0 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDN10181.1 - 0.011 16.2 1.2 0.021 15.3 0.0 2.0 2 0 0 2 2 1 0 ABC transporter cobW PF02492.19 EDN10181.1 - 0.015 14.9 0.2 0.035 13.7 0.2 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EDN10181.1 - 0.015 14.8 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EDN10181.1 - 0.017 15.0 0.0 0.081 12.8 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase KAP_NTPase PF07693.14 EDN10181.1 - 0.018 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain RNA_helicase PF00910.22 EDN10181.1 - 0.019 15.3 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EDN10181.1 - 0.023 14.6 0.3 0.053 13.4 0.3 1.6 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 EDN10181.1 - 0.04 13.6 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDN10181.1 - 0.048 13.6 0.8 0.078 12.9 0.0 1.7 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea Roc PF08477.13 EDN10181.1 - 0.054 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EDN10181.1 - 0.055 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDN10181.1 - 0.056 13.4 0.1 0.18 11.8 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDN10181.1 - 0.059 13.1 0.2 0.14 11.8 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EDN10181.1 - 0.093 13.2 0.0 0.093 13.2 0.0 2.2 2 0 0 2 2 1 0 AAA domain ATP_bind_1 PF03029.17 EDN10181.1 - 0.11 12.3 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MobB PF03205.14 EDN10181.1 - 0.11 12.4 0.1 0.29 11.0 0.1 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 EDN10181.1 - 0.12 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_11 PF13086.6 EDN10181.1 - 0.18 11.6 7.3 0.27 11.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain Whi5 PF08528.11 EDN10182.1 - 0.11 12.1 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Whi5 like adh_short_C2 PF13561.6 EDN10183.1 - 6.8e-35 120.7 0.2 3.5e-22 79.1 0.1 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN10183.1 - 3.2e-28 98.5 0.0 4.9e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase PWI PF01480.17 EDN10184.1 - 3.2e-10 40.2 0.1 8.1e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.6 EDN10184.1 - 5.7e-06 26.2 0.0 0.00016 21.6 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 EDN10184.1 - 0.00043 20.0 0.1 0.0046 16.8 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PrpF PF04303.13 EDN10184.1 - 0.14 11.1 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 PrpF protein RRM_occluded PF16842.5 EDN10184.1 - 0.2 11.5 0.0 0.54 10.2 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif GTP_EFTU PF00009.27 EDN10185.1 - 5.6e-66 221.8 0.0 7.8e-66 221.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDN10185.1 - 5.4e-34 116.6 0.0 2.1e-33 114.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EDN10185.1 - 6.8e-21 74.1 0.0 2.4e-20 72.4 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EDN10185.1 - 0.00013 22.0 0.0 0.00028 21.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Solute_trans_a PF03619.16 EDN10188.1 - 3.8e-40 138.1 10.4 3.5e-22 79.2 0.1 3.1 1 1 2 3 3 3 3 Organic solute transporter Ostalpha Dynactin PF12455.8 EDN10191.1 - 1.9e-100 335.8 2.5 1.9e-100 335.8 2.5 3.8 3 2 2 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 EDN10191.1 - 4.1e-06 26.7 0.0 8.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain MAD PF05557.13 EDN10191.1 - 0.001 17.5 4.8 0.001 17.5 4.8 4.5 3 1 2 5 5 5 1 Mitotic checkpoint protein DUF2353 PF09789.9 EDN10191.1 - 0.0035 16.7 24.2 0.0035 16.7 24.2 3.9 3 1 1 4 4 4 2 Uncharacterized coiled-coil protein (DUF2353) APG6_N PF17675.1 EDN10191.1 - 0.056 14.0 0.1 0.056 14.0 0.1 7.8 4 2 3 7 7 7 0 Apg6 coiled-coil region Hemerythrin PF01814.23 EDN10192.1 - 1e-06 29.4 0.1 1.3e-06 29.1 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain HAD_2 PF13419.6 EDN10193.1 - 6.5e-05 23.1 0.0 8.1e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN10193.1 - 0.0004 20.7 0.0 0.00053 20.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase KH_1 PF00013.29 EDN10196.1 - 6.3e-33 112.4 1.9 5.1e-07 29.4 0.0 6.9 7 0 0 7 7 7 5 KH domain SUV3_C PF12513.8 EDN10196.1 - 0.046 13.7 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal Diphthamide_syn PF01866.17 EDN10196.1 - 0.096 12.1 0.1 3.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Putative diphthamide synthesis protein VanW PF04294.13 EDN10196.1 - 0.15 11.7 0.0 0.75 9.5 0.0 2.2 2 0 0 2 2 2 0 VanW like protein OTT_1508_deam PF14441.6 EDN10197.1 - 1.3e-20 73.1 1.6 2.6e-20 72.2 1.6 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase Chitin_synth_2 PF03142.15 EDN10198.1 - 1.3e-249 829.2 1.0 2e-249 828.6 1.0 1.3 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EDN10198.1 - 2.3e-72 244.3 0.0 2.9e-71 240.6 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.11 EDN10198.1 - 1.1e-15 57.2 0.8 3.5e-15 55.7 0.8 1.9 1 0 0 1 1 1 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EDN10198.1 - 1.8e-12 47.6 1.8 3.8e-12 46.5 1.8 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDN10198.1 - 6.4e-10 39.3 0.0 4.4e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 EDN10198.1 - 5.6e-05 23.2 0.1 1.3 9.2 0.0 3.7 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 EDN10198.1 - 0.0023 17.8 0.0 0.83 9.4 0.0 2.7 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EDN10198.1 - 0.0075 15.8 0.1 0.17 11.3 0.2 2.6 2 1 0 2 2 2 1 Glycosyl transferase family 21 VirD1 PF07328.11 EDN10198.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 T-DNA border endonuclease VirD1 AAA_16 PF13191.6 EDN10198.1 - 0.12 12.7 0.9 0.95 9.8 0.1 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_7 PF12775.7 EDN10198.1 - 0.16 11.4 0.1 0.36 10.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Chitin_synth_2 PF03142.15 EDN10199.1 - 1.5e-173 578.2 0.0 3.7e-173 576.9 0.0 1.5 2 0 0 2 2 2 1 Chitin synthase DEK_C PF08766.11 EDN10199.1 - 1.7e-17 63.0 1.0 1e-16 60.5 1.4 2.1 2 0 0 2 2 2 1 DEK C terminal domain Cyt-b5 PF00173.28 EDN10199.1 - 7.1e-17 61.3 0.3 2.7e-11 43.4 0.1 3.1 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_trans_2_3 PF13632.6 EDN10199.1 - 2.1e-12 47.4 0.1 2.1e-12 47.4 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDN10199.1 - 5e-11 42.9 0.0 1.4e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Myosin_head PF00063.21 EDN10199.1 - 2.1e-09 36.2 0.0 1.5e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 Myosin head (motor domain) Glyco_transf_21 PF13506.6 EDN10199.1 - 0.00023 20.7 0.0 0.005 16.3 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDN10199.1 - 0.0057 16.5 0.0 0.3 10.9 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Peptidase_S8 PF00082.22 EDN10200.1 - 1.2e-33 116.7 8.5 1.7e-33 116.1 8.5 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDN10200.1 - 5e-10 39.9 0.1 1e-09 38.9 0.1 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 PLDc_2 PF13091.6 EDN10201.1 - 1.7e-20 73.3 0.6 3.2e-12 46.5 0.2 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDN10201.1 - 2.4e-05 24.3 0.1 0.14 12.3 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Regulator_TrmB PF11495.8 EDN10201.1 - 0.05 12.8 0.0 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB TPP_enzyme_N PF02776.18 EDN10202.1 - 9e-37 126.3 0.5 2.5e-36 124.9 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EDN10202.1 - 3.9e-19 69.0 0.0 6.6e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDN10202.1 - 3.2e-12 46.4 0.1 1.6e-11 44.1 0.0 2.3 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain FCH PF00611.23 EDN10202.1 - 0.021 15.1 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain DUF4248 PF14053.6 EDN10202.1 - 0.038 14.0 0.2 0.082 12.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) DUF2070 PF09843.9 EDN10203.1 - 2.6 6.2 9.5 3.4 5.9 9.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TatD_DNase PF01026.21 EDN10204.1 - 3.2e-28 98.8 0.0 5.4e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase Abhydrolase_1 PF00561.20 EDN10205.1 - 2.5e-21 76.5 0.0 7.8e-19 68.3 0.0 2.6 2 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDN10205.1 - 3.4e-17 62.5 0.0 2e-16 60.0 0.0 2.2 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDN10205.1 - 2.8e-15 57.5 5.3 1.5e-13 51.9 5.3 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EDN10205.1 - 0.0002 21.1 0.0 0.00042 20.0 0.0 1.6 1 0 0 1 1 1 1 Putative esterase DUF915 PF06028.11 EDN10205.1 - 0.00043 19.7 0.0 0.0008 18.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase2 PF12740.7 EDN10205.1 - 0.0068 15.3 0.0 0.0098 14.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme LIDHydrolase PF10230.9 EDN10205.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_2 PF02230.16 EDN10205.1 - 0.075 12.8 0.0 25 4.6 0.0 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 EDN10205.1 - 0.079 13.1 0.3 0.35 10.9 0.2 2.2 2 1 0 2 2 2 0 Thioesterase domain Spo7 PF03907.13 EDN10206.1 - 1.7e-65 220.6 0.1 5.9e-65 218.8 0.0 1.7 2 0 0 2 2 2 1 Spo7-like protein DUF2722 PF10846.8 EDN10206.1 - 0.0012 17.9 0.9 0.0012 17.8 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 EDN10206.1 - 0.036 14.7 6.7 0.06 14.0 6.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 EDN10206.1 - 0.21 11.2 12.9 0.3 10.7 12.9 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 EDN10206.1 - 0.36 10.8 11.0 0.44 10.5 11.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 EDN10206.1 - 2.4 8.1 5.4 3.2 7.7 5.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SUIM_assoc PF16619.5 EDN10206.1 - 8.7 6.5 18.4 27 4.9 18.4 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SARAF PF06682.12 EDN10206.1 - 9.9 5.7 8.4 59 3.2 6.5 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis MCM PF00493.23 EDN10207.1 - 4.1e-91 304.1 0.2 7e-91 303.3 0.2 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDN10207.1 - 1.3e-29 102.6 0.0 2.3e-29 101.8 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDN10207.1 - 3.6e-24 85.0 0.9 8.7e-24 83.8 0.9 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDN10207.1 - 6.8e-09 36.2 0.0 2.1e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDN10207.1 - 1.2e-06 28.1 0.0 1.5e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDN10207.1 - 0.0032 17.3 0.0 0.0083 16.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDN10207.1 - 0.13 12.0 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain PPR_2 PF13041.6 EDN10208.1 - 6.3e-15 55.1 0.3 7.5e-08 32.5 0.0 6.1 7 1 1 8 8 8 3 PPR repeat family PPR_3 PF13812.6 EDN10208.1 - 2.2e-12 46.9 0.1 0.007 16.4 0.0 5.6 5 1 1 6 6 6 2 Pentatricopeptide repeat domain PPR PF01535.20 EDN10208.1 - 4.4e-11 42.3 3.4 0.063 13.6 0.0 8.9 10 0 0 10 10 10 2 PPR repeat PPR_long PF17177.4 EDN10208.1 - 2.3e-09 36.9 0.1 1e-05 25.0 0.0 3.6 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EDN10208.1 - 5.8e-05 22.7 0.0 2.8 7.7 0.0 5.3 6 0 0 6 6 6 1 PPR repeat TPR_14 PF13428.6 EDN10208.1 - 0.0041 17.8 2.2 1.5 9.9 0.0 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDN10208.1 - 0.012 16.3 3.4 1.7 9.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat MRP-S27 PF10037.9 EDN10208.1 - 0.042 12.7 0.0 0.2 10.5 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S27 SRP68 PF16969.5 EDN10209.1 - 2e-185 618.0 0.0 2.3e-185 617.8 0.0 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 p450 PF00067.22 EDN10210.1 - 3.3e-55 187.6 0.0 4.9e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Rhodanese PF00581.20 EDN10211.1 - 0.019 15.5 0.0 0.045 14.3 0.0 1.7 1 0 0 1 1 1 0 Rhodanese-like domain Ribosomal_60s PF00428.19 EDN10211.1 - 0.4 11.3 7.7 1.8 9.2 1.5 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2188 PF09954.9 EDN10211.1 - 2.3 8.4 7.1 1.1 9.4 2.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) GTP_EFTU PF00009.27 EDN10212.1 - 1.5e-33 116.0 0.0 1.5e-33 116.0 0.0 3.0 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDN10212.1 - 9.6e-20 70.7 0.1 3.1e-19 69.0 0.1 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EDN10212.1 - 9.5e-11 41.9 0.5 2.6e-09 37.3 0.0 3.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EDN10212.1 - 7.9e-09 35.3 0.1 3.3e-08 33.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EDN10212.1 - 5.8e-07 29.6 0.6 9.4e-06 25.7 0.0 3.1 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EDN10212.1 - 0.00029 21.1 0.0 0.0011 19.2 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EDN10212.1 - 0.021 14.6 0.0 0.065 13.0 0.0 2.0 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MMS1_N PF10433.9 EDN10213.1 - 1.7e-95 320.5 0.0 7.2e-95 318.4 0.0 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term RabGAP-TBC PF00566.18 EDN10214.1 - 4e-20 72.4 0.1 5.7e-20 71.9 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ubiquitin PF00240.23 EDN10216.1 - 3.7e-34 116.3 0.6 4.9e-34 115.9 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EDN10216.1 - 3.2e-32 110.2 11.8 4.9e-32 109.6 11.8 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EDN10216.1 - 2.1e-16 59.5 0.7 3e-16 59.0 0.7 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDN10216.1 - 2e-05 24.9 0.1 7.4e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EDN10216.1 - 0.0035 17.6 0.0 0.0055 17.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDN10216.1 - 0.0039 17.1 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDN10216.1 - 0.007 16.5 0.1 0.015 15.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EDN10216.1 - 0.014 15.4 1.0 4.2 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EDN10216.1 - 0.026 15.1 0.1 0.031 14.9 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EDN10216.1 - 0.082 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain eIF-5a PF01287.20 EDN10218.1 - 3.8e-27 94.2 1.7 5.3e-27 93.7 1.7 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EDN10218.1 - 0.015 15.4 0.6 0.036 14.1 0.0 2.0 3 0 0 3 3 3 0 Elongation factor P (EF-P) KOW-like domain Vps52 PF04129.12 EDN10219.1 - 5.7e-87 292.6 1.7 6.2e-58 196.8 2.1 3.1 1 1 2 3 3 3 3 Vps52 / Sac2 family Sec3_C PF09763.9 EDN10219.1 - 4.3e-07 28.7 3.3 6.4e-07 28.2 3.3 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 MitMem_reg PF13012.6 EDN10219.1 - 0.0026 18.2 1.4 0.57 10.6 1.4 2.7 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function APG17 PF04108.12 EDN10219.1 - 0.024 13.8 4.2 0.043 12.9 0.2 2.2 2 0 0 2 2 2 0 Autophagy protein Apg17 Xrn1_D3 PF18194.1 EDN10219.1 - 0.069 13.3 0.1 0.24 11.5 0.1 2.0 1 0 0 1 1 1 0 Exoribonuclease 1 Domain-3 DAO PF01266.24 EDN10220.1 - 3.2e-61 207.9 2.6 4.3e-61 207.5 2.6 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDN10220.1 - 0.0002 21.5 0.0 0.00043 20.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Fe-ADH PF00465.19 EDN10221.1 - 1.2e-20 73.6 0.5 1.6e-17 63.4 0.0 2.0 1 1 1 2 2 2 2 Iron-containing alcohol dehydrogenase CEP44 PF15007.6 EDN10222.1 - 0.1 12.8 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Centrosomal spindle body, CEP44 RRM_1 PF00076.22 EDN10223.1 - 3.2e-78 257.5 8.2 1.8e-20 72.5 0.4 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDN10223.1 - 4.6e-10 39.2 0.2 0.0046 16.5 0.0 4.8 3 2 3 6 6 6 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDN10223.1 - 9.7e-05 22.4 0.9 6.7 6.9 0.0 5.4 5 1 0 5 5 5 1 RNA recognition motif PABP PF00658.18 EDN10223.1 - 0.00032 20.8 0.0 0.0018 18.5 0.0 2.3 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain CbiG_mid PF11761.8 EDN10223.1 - 0.00039 20.5 0.0 3.7 7.7 0.0 3.5 3 0 0 3 3 3 1 Cobalamin biosynthesis central region Nup35_RRM_2 PF14605.6 EDN10223.1 - 0.00085 19.3 1.4 20 5.3 0.1 4.5 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif YflT PF11181.8 EDN10223.1 - 0.0062 17.0 7.5 0.098 13.2 0.7 3.3 3 0 0 3 3 3 1 Heat induced stress protein YflT PhetRS_B1 PF18262.1 EDN10223.1 - 0.08 13.2 0.5 29 5.0 0.0 3.3 3 0 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain NBD_C PF17042.5 EDN10223.1 - 0.087 13.3 1.4 1.7 9.1 0.1 2.6 2 0 0 2 2 2 0 Nucleotide-binding C-terminal domain RRM_occluded PF16842.5 EDN10223.1 - 0.11 12.4 0.3 11 5.9 0.0 3.8 4 1 0 4 4 4 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EDN10223.1 - 0.25 11.4 2.1 3.9 7.6 0.1 3.4 3 1 0 3 3 3 0 Limkain b1 NPR3 PF03666.13 EDN10223.1 - 0.81 8.4 4.3 1.7 7.4 4.3 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HECT PF00632.25 EDN10224.1 - 1.3e-78 264.6 0.0 1.9e-78 264.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EDN10224.1 - 0.0036 17.0 1.5 0.014 15.1 1.5 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif MRP-L27 PF09809.9 EDN10225.1 - 3.6e-14 52.5 0.2 5.6e-14 51.9 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 PIG-H PF10181.9 EDN10225.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component Utp14 PF04615.13 EDN10226.1 - 6.2e-171 570.7 62.4 1.9e-129 433.5 53.1 3.1 1 1 2 3 3 3 2 Utp14 protein Glyco_hydro81C PF17652.1 EDN10227.1 - 1.3e-158 527.8 0.3 1.6e-158 527.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EDN10227.1 - 4.2e-117 390.9 0.1 8.7e-117 389.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain SpoIIIAH PF12685.7 EDN10230.1 - 2.5 7.9 6.5 2 8.2 0.4 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein Na_Ca_ex PF01699.24 EDN10231.1 - 1.8e-42 144.9 39.6 3e-21 76.0 14.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Ribosomal_S7 PF00177.21 EDN10232.1 - 8.8e-25 87.1 0.0 2.4e-24 85.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S7p/S5e Dimer_Tnp_hAT PF05699.14 EDN10232.1 - 0.041 13.7 0.0 0.097 12.5 0.0 1.6 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region IMUP PF15761.5 EDN10232.1 - 0.87 10.3 7.4 0.23 12.2 1.2 2.5 2 0 0 2 2 2 0 Immortalisation up-regulated protein Peptidase_S28 PF05577.12 EDN10233.1 - 3.2e-50 171.2 0.0 3e-49 168.0 0.0 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EDN10233.1 - 0.0072 16.0 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDN10233.1 - 0.023 14.2 0.1 0.079 12.4 0.1 1.9 1 0 0 1 1 1 0 Prolyl oligopeptidase family CitMHS PF03600.16 EDN10234.1 - 4.7e-33 114.7 56.3 1.2e-28 100.2 36.3 1.5 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 EDN10234.1 - 1.5e-27 96.8 30.9 2.4e-27 96.1 30.9 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region Ribosomal_S8e PF01201.22 EDN10235.1 - 4.5e-39 133.8 2.8 1.2e-37 129.1 2.8 2.0 1 1 0 1 1 1 1 Ribosomal protein S8e Metallophos PF00149.28 EDN10236.1 - 3.4e-06 27.7 0.1 4.6e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN10236.1 - 0.055 13.7 0.2 0.58 10.3 0.2 2.1 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_20 PF00728.22 EDN10237.1 - 9.8e-61 206.1 0.0 1.3e-60 205.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EDN10237.1 - 3.9e-26 92.3 0.0 6.5e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EDN10237.1 - 0.00018 22.3 0.0 0.00036 21.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DOCK_N PF16172.5 EDN10238.1 - 1e-49 169.5 0.0 2.4e-49 168.3 0.0 1.7 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EDN10238.1 - 9.9e-41 140.0 3.2 2.2e-40 138.8 3.2 1.5 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EDN10238.1 - 4.7e-28 98.3 0.0 1.8e-27 96.5 0.0 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins Sec3_C PF09763.9 EDN10239.1 - 1.1e-80 272.0 0.1 1.2e-80 271.8 0.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 Spo0A_C PF08769.11 EDN10239.1 - 0.035 14.2 0.2 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal TBCC_N PF16752.5 EDN10239.1 - 0.074 13.5 0.1 15 6.0 0.0 2.6 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Sec3_C PF09763.9 EDN10240.1 - 1.4e-81 274.9 2.7 2.3e-81 274.2 2.7 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EDN10240.1 - 1.2e-28 99.0 0.1 3.2e-28 97.7 0.1 1.8 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH GETHR PF05671.11 EDN10240.1 - 0.15 11.4 8.4 0.016 14.6 3.3 1.9 2 0 0 2 2 2 0 GETHR pentapeptide repeat (5 copies) RNase_H PF00075.24 EDN10241.1 - 2.2e-12 47.4 0.0 4.6e-12 46.3 0.0 1.5 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN10241.1 - 0.12 12.2 0.1 0.38 10.6 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like EKLF_TAD1 PF16832.5 EDN10241.1 - 4 7.4 4.8 2.5 8.0 0.2 2.6 3 0 0 3 3 3 0 Erythroid krueppel-like transcription factor, transactivation 1 RVT_1 PF00078.27 EDN10244.1 - 7.6e-27 94.3 0.0 1.7e-26 93.1 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 EDN10244.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease TFIIE_beta PF02186.15 EDN10244.1 - 0.089 13.1 0.2 4.2 7.7 0.0 3.3 3 0 0 3 3 3 0 TFIIE beta subunit core domain DDE_1 PF03184.19 EDN10246.1 - 2.4e-13 50.1 0.1 5.5e-11 42.4 0.0 2.7 2 1 1 3 3 3 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN10246.1 - 3.7e-11 42.9 0.0 1.2e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN10246.1 - 2.8e-07 30.1 0.1 5.7e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Fic PF02661.18 EDN10247.1 - 6.8e-10 39.7 0.1 1.3e-09 38.8 0.1 1.5 1 0 0 1 1 1 1 Fic/DOC family RTC4 PF14474.6 EDN10248.1 - 2.7e-10 40.5 0.0 6.9e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 RTC4-like domain Myb_DNA-bind_6 PF13921.6 EDN10248.1 - 0.00016 21.8 3.1 0.00016 21.8 3.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN10248.1 - 0.00075 19.6 2.2 0.0017 18.5 2.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3678 PF12435.8 EDN10250.1 - 1.7 8.1 6.0 0.45 9.9 0.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3678) UCH PF00443.29 EDN10251.1 - 8.1e-40 136.9 0.0 8.1e-40 136.9 0.0 2.0 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDN10251.1 - 1.3e-13 51.3 0.0 1.3e-13 51.3 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EDN10251.1 - 6.3 6.2 10.1 0.47 9.9 0.5 2.7 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Yos1 PF08571.10 EDN10252.1 - 1.6e-23 82.8 0.1 7.8e-23 80.5 0.0 2.1 1 1 2 3 3 3 1 Yos1-like Dynamitin PF04912.14 EDN10253.1 - 1.8e-40 139.5 0.5 2.5e-40 139.0 0.5 1.1 1 0 0 1 1 1 1 Dynamitin GrpE PF01025.19 EDN10253.1 - 0.0054 16.4 0.1 0.0095 15.6 0.1 1.3 1 0 0 1 1 1 1 GrpE APG6_N PF17675.1 EDN10253.1 - 0.025 15.1 3.1 0.045 14.3 3.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Aldedh PF00171.22 EDN10256.1 - 4.2e-122 408.0 1.8 9.5e-73 245.3 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family LuxC PF05893.14 EDN10256.1 - 0.001 18.2 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) Calreticulin PF00262.18 EDN10257.1 - 3.1e-170 565.9 24.5 2e-169 563.2 17.0 2.0 2 0 0 2 2 2 2 Calreticulin family Aldolase_II PF00596.21 EDN10258.1 - 3.2e-45 154.4 0.0 3.7e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PX PF00787.24 EDN10259.1 - 4.4e-25 87.8 0.1 9.3e-25 86.8 0.0 1.6 2 0 0 2 2 2 1 PX domain Ribosomal_L31 PF01197.18 EDN10260.1 - 0.07 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L31 TcdB_N PF12918.7 EDN10261.1 - 0.085 13.2 1.3 0.25 11.6 1.3 1.9 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain 4HBT_2 PF13279.6 EDN10262.1 - 1.1e-26 93.7 0.0 1.7e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EDN10262.1 - 0.005 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily Complex1_LYR_2 PF13233.6 EDN10263.1 - 1.9e-06 28.5 0.2 2.1e-06 28.4 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EDN10263.1 - 0.00015 21.7 0.2 0.00018 21.5 0.2 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Methyltransf_25 PF13649.6 EDN10264.1 - 2.1e-08 34.8 0.0 3.6e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN10264.1 - 2.1e-06 28.3 0.0 4e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN10264.1 - 0.0014 18.4 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN10264.1 - 0.0068 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EDN10264.1 - 0.0069 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Exo_endo_phos PF03372.23 EDN10265.1 - 1.2e-19 70.8 0.0 1.1e-18 67.6 0.0 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 EDN10265.1 - 3.8e-11 43.0 5.7 1.5e-07 31.6 0.6 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDN10265.1 - 2.6e-08 33.5 4.2 2.1e-07 30.6 3.9 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EDN10265.1 - 0.33 11.7 5.6 18 6.3 0.0 3.7 4 0 0 4 4 4 0 Leucine Rich Repeat DUF1348 PF07080.11 EDN10266.1 - 2.6e-53 179.4 3.0 3.2e-53 179.1 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EDN10266.1 - 9e-05 23.1 0.1 0.00012 22.7 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EDN10266.1 - 0.0057 17.0 0.0 0.0079 16.6 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) zf-CCHC_3 PF13917.6 EDN10266.1 - 0.2 11.6 0.6 0.39 10.7 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle FTA2 PF13095.6 EDN10267.1 - 6.4e-39 133.8 0.0 5.3e-38 130.8 0.0 2.1 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 DUF2316 PF10078.9 EDN10267.1 - 0.029 14.6 0.5 0.054 13.7 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) Hydrolase_4 PF12146.8 EDN10268.1 - 6.6e-33 113.9 0.0 1.1e-32 113.2 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDN10268.1 - 3.9e-06 27.6 0.0 5.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDN10268.1 - 6.3e-05 22.7 0.1 9.8e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EDN10268.1 - 0.0012 18.7 0.0 0.015 15.1 0.0 2.0 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Chlorophyllase2 PF12740.7 EDN10268.1 - 0.0041 16.1 0.0 0.0069 15.3 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme DUF1749 PF08538.10 EDN10268.1 - 0.012 14.7 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Chlorophyllase PF07224.11 EDN10268.1 - 0.034 13.2 0.2 0.15 11.1 0.2 1.9 1 1 0 1 1 1 0 Chlorophyllase PAF-AH_p_II PF03403.13 EDN10268.1 - 0.16 10.5 0.3 3.2 6.2 0.0 2.0 1 1 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II GCD14 PF08704.10 EDN10269.1 - 7.8e-06 25.7 0.0 0.01 15.5 0.0 2.4 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Metallophos PF00149.28 EDN10270.1 - 1.7e-14 54.8 0.0 2.5e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN10270.1 - 0.00074 19.7 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain NAD_binding_1 PF00175.21 EDN10271.1 - 4.6e-07 30.4 0.0 0.0039 17.8 0.0 3.1 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EDN10271.1 - 6.8e-06 26.3 0.0 0.00067 19.8 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain MARVEL PF01284.23 EDN10272.1 - 0.001 19.1 0.3 0.0019 18.2 0.3 1.5 1 1 0 1 1 1 1 Membrane-associating domain E1-E2_ATPase PF00122.20 EDN10273.1 - 2e-47 161.1 1.1 2e-47 161.1 1.1 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EDN10273.1 - 3.4e-37 128.8 0.1 5e-37 128.2 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDN10273.1 - 0.00044 20.1 0.3 0.0011 18.7 0.2 1.7 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase PCI PF01399.27 EDN10274.1 - 4.3e-05 24.0 0.0 6.9e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 EDN10274.1 - 0.00068 19.5 0.2 0.0018 18.1 0.1 1.7 2 0 0 2 2 2 1 COP9 signalosome complex subunit 7a helix I domain Bromodomain PF00439.25 EDN10276.1 - 1.4e-24 85.9 0.8 3.1e-24 84.8 0.8 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EDN10276.1 - 0.0075 16.5 0.0 0.018 15.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Rad1 PF02144.16 EDN10277.1 - 4.4e-96 321.2 0.0 5.7e-96 320.8 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 AAA_23 PF13476.6 EDN10278.1 - 1.4e-18 68.1 3.3 1.4e-18 68.1 3.3 7.4 3 2 3 6 6 6 1 AAA domain SbcCD_C PF13558.6 EDN10278.1 - 1.4e-06 28.4 0.0 5.2e-06 26.6 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit FlaC_arch PF05377.11 EDN10278.1 - 0.059 13.8 0.3 0.059 13.8 0.3 11.1 11 2 1 13 13 13 0 Flagella accessory protein C (FlaC) Lipl32 PF12103.8 EDN10278.1 - 0.13 11.9 0.6 0.43 10.2 0.6 1.9 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order KNOX2 PF03791.13 EDN10278.1 - 0.18 11.4 4.6 7.2 6.2 0.1 4.2 3 0 0 3 3 3 0 KNOX2 domain DUF3231 PF11553.8 EDN10278.1 - 0.21 11.2 4.1 0.17 11.5 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3231) TBD PF12845.7 EDN10278.1 - 3.7 7.5 8.4 4.7 7.2 0.2 3.4 3 0 0 3 3 3 0 TBD domain Myb_DNA-bind_5 PF13873.6 EDN10278.1 - 6.7 6.9 16.2 2.3 8.3 0.1 5.4 4 1 1 5 5 5 0 Myb/SANT-like DNA-binding domain DUF1492 PF07374.11 EDN10278.1 - 7.5 6.8 11.2 5.2 7.3 0.3 4.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1492) PAS_3 PF08447.12 EDN10279.1 - 1.5e-14 54.1 0.0 2.6e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold GATA PF00320.27 EDN10279.1 - 3.6e-14 52.1 4.4 3.6e-14 52.1 4.4 1.7 2 0 0 2 2 2 1 GATA zinc finger PAS PF00989.25 EDN10279.1 - 2.7e-07 30.6 0.0 4.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 EDN10279.1 - 1.9e-05 24.7 0.0 3.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EDN10279.1 - 0.0024 18.1 0.1 0.008 16.4 0.0 1.8 2 0 0 2 2 2 1 PAS domain PPP4R2 PF09184.11 EDN10280.1 - 2.8e-09 37.0 0.0 6.7e-09 35.8 0.0 2.0 1 1 0 1 1 1 1 PPP4R2 DUF155 PF02582.14 EDN10282.1 - 1.2e-53 181.8 0.0 1.9e-53 181.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 AMP-binding PF00501.28 EDN10283.1 - 2.3e-23 82.5 0.2 1.3e-22 80.0 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme zf-C2H2 PF00096.26 EDN10284.1 - 7.2e-14 51.4 10.4 7.1e-05 23.0 1.2 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN10284.1 - 3.4e-12 46.2 8.8 3.1e-05 24.2 0.8 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN10284.1 - 3.1e-06 27.6 10.0 0.022 15.6 0.9 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf_UBZ PF18439.1 EDN10284.1 - 0.022 14.3 2.8 1.5 8.5 0.1 2.7 3 0 0 3 3 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 EDN10284.1 - 0.023 15.0 0.5 4.2 7.8 0.0 3.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDN10284.1 - 0.024 15.0 2.2 0.22 12.0 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-ribbon_3 PF13248.6 EDN10284.1 - 0.088 12.3 2.0 3.1 7.3 0.0 3.0 3 0 0 3 3 3 0 zinc-ribbon domain ADK_lid PF05191.14 EDN10284.1 - 0.2 11.7 3.5 22 5.2 0.2 3.4 1 1 2 3 3 3 0 Adenylate kinase, active site lid zf-C2H2_11 PF16622.5 EDN10284.1 - 0.21 11.4 2.2 1.6 8.6 0.4 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type HNH PF01844.23 EDN10284.1 - 0.47 10.7 2.3 20 5.5 0.0 3.4 3 0 0 3 3 3 0 HNH endonuclease FOXP-CC PF16159.5 EDN10284.1 - 0.63 10.7 5.2 0.12 13.0 1.3 1.9 2 0 0 2 2 1 0 FOXP coiled-coil domain XPA_N PF01286.18 EDN10284.1 - 0.71 10.0 6.5 0.46 10.6 0.4 2.6 3 0 0 3 3 3 0 XPA protein N-terminal DUF4764 PF15961.5 EDN10284.1 - 0.72 8.5 7.7 0.044 12.5 0.9 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4764) Zn-ribbon_8 PF09723.10 EDN10284.1 - 1.2 9.3 4.7 17 5.6 0.9 2.7 1 1 2 3 3 3 0 Zinc ribbon domain DZR PF12773.7 EDN10284.1 - 1.8 8.7 5.6 8.3 6.5 4.1 2.3 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_6 PF13912.6 EDN10284.1 - 2.1 8.5 4.5 5.1 7.2 0.3 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger E1-E2_ATPase PF00122.20 EDN10286.1 - 1.2e-26 93.3 18.5 8.6e-20 71.0 0.9 3.5 4 1 0 4 4 4 2 E1-E2 ATPase Cation_ATPase PF13246.6 EDN10286.1 - 1.5e-21 76.2 0.0 3.2e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDN10286.1 - 1.5e-18 67.9 0.0 1.3e-14 55.0 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN10286.1 - 4e-14 52.1 0.0 1.3e-13 50.5 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 EDN10286.1 - 1e-10 41.6 2.0 2.3e-10 40.5 0.0 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase_3 PF08282.12 EDN10286.1 - 2.2e-06 27.6 0.3 0.00032 20.5 0.5 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase GCP5-Mod21 PF14609.6 EDN10286.1 - 0.073 11.4 0.8 0.11 10.8 0.8 1.1 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 zf-UBP PF02148.19 EDN10287.1 - 8.9e-20 70.8 4.6 2.5e-19 69.3 4.6 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.12 EDN10287.1 - 6.6e-10 39.1 1.5 7e-06 26.2 0.0 2.4 1 1 1 2 2 2 2 BRCA1-associated protein 2 zf-RING_2 PF13639.6 EDN10287.1 - 4.1e-08 33.4 9.5 4.1e-08 33.4 9.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDN10287.1 - 1.3e-05 24.9 9.7 1.3e-05 24.9 9.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDN10287.1 - 0.00061 20.0 7.1 0.00061 20.0 7.1 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EDN10287.1 - 0.00094 18.9 5.7 0.00094 18.9 5.7 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EDN10287.1 - 0.00095 19.0 5.8 0.00095 19.0 5.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN10287.1 - 0.0011 18.8 8.8 0.0011 18.8 8.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDN10287.1 - 0.0014 18.6 6.0 0.0014 18.6 6.0 2.5 2 1 1 3 3 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDN10287.1 - 0.0019 18.1 7.9 0.0019 18.1 7.9 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 EDN10287.1 - 0.0031 17.3 3.2 0.0075 16.1 3.2 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EDN10287.1 - 0.01 15.8 5.1 0.026 14.6 5.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDN10287.1 - 0.18 11.7 19.5 0.076 12.9 9.8 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 TFIIA PF03153.13 EDN10287.1 - 0.46 10.4 10.7 0.15 12.0 4.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-RING_4 PF14570.6 EDN10287.1 - 2.4 8.0 6.8 5.9 6.8 6.8 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TerY_C PF15616.6 EDN10287.1 - 2.8 8.0 13.0 0.47 10.6 2.7 2.4 1 1 1 2 2 2 0 TerY-C metal binding domain Gti1_Pac2 PF09729.9 EDN10287.1 - 9.6 6.3 9.3 7.7 6.6 1.7 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family ubiquitin PF00240.23 EDN10288.1 - 1.8e-133 434.4 19.4 3.3e-33 113.3 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EDN10288.1 - 7.8e-63 208.3 21.1 2e-15 56.4 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDN10288.1 - 2e-22 79.4 9.8 0.00043 20.7 0.1 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EDN10288.1 - 2.7e-16 59.2 2.7 0.027 14.4 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EDN10288.1 - 4.7e-15 55.7 6.9 0.029 14.7 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDN10288.1 - 2.2e-14 53.5 2.7 0.11 12.6 0.0 5.0 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDN10288.1 - 2.5e-13 50.5 1.3 0.21 12.2 0.0 4.2 1 1 0 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EDN10288.1 - 3.4e-10 40.0 0.4 0.58 10.0 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EDN10288.1 - 1.6e-06 28.1 24.2 13 5.9 0.2 7.9 8 0 0 8 8 8 0 Ubiquitin-like domain Methyltrans_RNA PF04452.14 EDN10288.1 - 3.6e-06 26.5 0.6 1.8 7.8 0.0 3.2 3 0 0 3 3 3 3 RNA methyltransferase DUF2870 PF11069.8 EDN10288.1 - 7.3e-06 26.3 0.0 30 5.1 0.0 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) DUF3861 PF12977.7 EDN10288.1 - 7.4e-06 26.1 2.7 4.3 7.6 0.0 4.2 4 0 0 4 4 4 1 Domain of Unknown Function with PDB structure (DUF3861) UDP-g_GGTase PF06427.11 EDN10288.1 - 7.4e-05 22.8 3.3 5.7 7.1 0.0 3.9 4 0 0 4 4 4 1 UDP-glucose:Glycoprotein Glucosyltransferase ACT_5 PF13710.6 EDN10288.1 - 0.0002 21.1 4.2 10 6.1 0.0 4.3 4 0 0 4 4 4 0 ACT domain DUF969 PF06149.12 EDN10288.1 - 0.00035 20.1 0.0 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) Big_7 PF17957.1 EDN10288.1 - 0.00098 19.8 0.3 52 4.7 0.0 4.0 4 0 0 4 4 4 0 Bacterial Ig domain Raf1_HTH PF18579.1 EDN10288.1 - 0.0035 17.0 0.0 98 2.8 0.0 4.1 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain YcgR_2 PF12945.7 EDN10288.1 - 0.0041 17.2 5.4 28 4.9 0.1 4.2 4 0 0 4 4 4 0 Flagellar protein YcgR DUF493 PF04359.14 EDN10288.1 - 0.0043 17.6 0.0 1.2e+02 3.3 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 EDN10288.1 - 0.007 16.5 0.0 91 3.3 0.0 4.2 4 0 0 4 4 4 0 ORF11CD3 domain NEAT PF05031.12 EDN10288.1 - 0.0073 16.9 0.7 1.1 9.9 0.1 2.6 1 1 2 3 3 3 2 Iron Transport-associated domain ACT_4 PF13291.6 EDN10288.1 - 0.0097 16.5 1.0 49 4.6 0.0 4.1 4 0 0 4 4 4 0 ACT domain Myosin_N PF02736.19 EDN10288.1 - 0.14 12.0 6.2 1.1e+02 2.8 0.0 5.2 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain Baculo_p48 PF04878.13 EDN10288.1 - 0.16 10.9 0.0 61 2.4 0.0 2.9 3 0 0 3 3 3 0 Baculovirus P48 protein ProRS-C_2 PF09181.10 EDN10288.1 - 0.22 11.7 5.4 68 3.7 0.1 4.0 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal HAMP_N3 PF18575.1 EDN10288.1 - 0.27 10.8 1.2 2e+02 1.6 0.0 3.9 4 0 0 4 4 4 0 HAMP N-terminal domain 3 Tash_PEST PF07708.11 EDN10288.1 - 0.71 10.1 17.7 6.2 7.1 1.4 4.2 4 0 0 4 4 4 0 Tash protein PEST motif Plexin_cytopl PF08337.12 EDN10288.1 - 3.6 6.1 17.2 14 4.2 0.3 4.9 4 3 0 4 4 4 0 Plexin cytoplasmic RasGAP domain PI3K_p85B PF02192.16 EDN10288.1 - 4.8 7.0 8.6 96 2.8 0.1 4.1 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain Prenyltrans PF00432.21 EDN10290.1 - 4.4e-20 71.1 26.3 3.5e-10 39.5 0.0 5.4 4 1 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat DUF4448 PF14610.6 EDN10294.1 - 9.7e-43 146.1 0.0 1.3e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) LapA_dom PF06305.11 EDN10294.1 - 0.079 12.8 0.6 0.15 11.9 0.6 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PetL PF05115.14 EDN10294.1 - 1.1 9.3 4.4 0.53 10.3 0.5 2.1 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit VI (PetL) HMGL-like PF00682.19 EDN10295.1 - 1.1e-80 271.0 0.5 1.5e-80 270.6 0.5 1.2 1 0 0 1 1 1 1 HMGL-like Endonuc-BglII PF09195.11 EDN10295.1 - 0.12 12.2 0.1 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 Restriction endonuclease BglII Hpt PF01627.23 EDN10296.1 - 2.3e-11 43.8 0.0 2.6e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Hpt domain SART-1 PF03343.13 EDN10298.1 - 8.6e-189 629.1 64.6 8.6e-189 629.1 64.6 1.6 2 0 0 2 2 2 1 SART-1 family PTH2 PF01981.16 EDN10298.1 - 1.2e-20 74.0 0.0 1.2e-20 74.0 0.0 3.4 4 1 0 4 4 4 1 Peptidyl-tRNA hydrolase PTH2 SIMPL PF04402.14 EDN10298.1 - 0.12 12.8 3.0 0.32 11.4 3.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Ribosomal_60s PF00428.19 EDN10298.1 - 1.3 9.7 11.8 0.23 12.1 1.0 4.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein Aminotran_1_2 PF00155.21 EDN10299.1 - 5.3e-95 318.7 0.0 6e-95 318.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 EDN10300.1 - 3.5e-16 58.9 0.0 5.8e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDN10300.1 - 5.2e-06 25.7 0.0 1.1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDN10300.1 - 0.00073 18.9 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EDN10300.1 - 0.019 13.5 0.0 0.029 12.9 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ribosomal_L30 PF00327.20 EDN10301.1 - 4.4e-14 52.1 0.3 6e-14 51.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Sec6 PF06046.13 EDN10302.1 - 1.5e-180 601.4 13.4 2.1e-180 600.9 13.4 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 HSCB_C PF07743.13 EDN10302.1 - 3.8 8.1 6.4 6.6 7.3 0.3 3.7 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain AKAP7_NLS PF10469.9 EDN10303.1 - 9.6e-15 55.0 0.0 1.9e-14 54.0 0.0 1.6 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Frataxin_Cyay PF01491.16 EDN10304.1 - 2.7e-24 85.3 0.2 4.8e-24 84.5 0.2 1.4 1 1 0 1 1 1 1 Frataxin-like domain zf-CSL PF05207.13 EDN10305.1 - 6.6e-22 77.0 0.4 8.5e-22 76.7 0.4 1.2 1 0 0 1 1 1 1 CSL zinc finger zf-RING_7 PF02591.15 EDN10305.1 - 0.045 13.9 0.1 0.092 12.9 0.1 1.5 1 0 0 1 1 1 0 C4-type zinc ribbon domain PH_6 PF15406.6 EDN10307.1 - 5.4e-35 120.1 1.6 5.4e-35 120.1 1.6 3.8 3 1 1 4 4 4 1 Pleckstrin homology domain PH PF00169.29 EDN10307.1 - 6e-08 33.1 0.4 3.9e-07 30.5 0.0 2.5 2 1 0 2 2 2 1 PH domain PNTB PF02233.16 EDN10309.1 - 2.8e-176 587.0 20.4 2.8e-176 587.0 20.4 1.9 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EDN10309.1 - 2.7e-73 245.8 0.4 9.2e-73 244.1 0.1 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EDN10309.1 - 5.2e-45 153.1 0.0 1.7e-44 151.4 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EDN10309.1 - 6.7e-29 100.2 4.1 6.7e-29 100.2 4.1 5.1 5 1 1 6 6 6 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EDN10309.1 - 0.0009 18.6 3.1 2.3 7.5 0.0 3.9 4 0 0 4 4 4 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EDN10309.1 - 0.059 12.6 0.2 0.13 11.4 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 EDN10309.1 - 0.073 12.8 0.5 0.59 9.9 0.3 2.7 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Peptidase_M17_N PF02789.17 EDN10309.1 - 0.2 11.5 1.2 6.8 6.6 0.0 2.7 3 0 0 3 3 3 0 Cytosol aminopeptidase family, N-terminal domain DUF5340 PF17275.2 EDN10310.1 - 0.086 13.0 0.0 0.096 12.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5340) bZIP_2 PF07716.15 EDN10311.1 - 9.8e-05 22.4 8.4 0.00018 21.5 8.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDN10311.1 - 0.0037 17.3 6.2 0.0082 16.2 6.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor Lipase_GDSL_2 PF13472.6 EDN10312.1 - 3.5e-09 37.3 0.0 5e-09 36.8 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDN10312.1 - 6.5e-08 32.8 0.0 9.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase MCPVI PF02993.14 EDN10312.1 - 0.16 11.8 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Minor capsid protein VI DIOX_N PF14226.6 EDN10313.1 - 2.1e-28 99.5 0.0 3.2e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EDN10313.1 - 1.6e-10 41.3 0.0 2.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RVT_2 PF07727.14 EDN10314.1 - 1e-43 149.8 0.0 1.5e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 EDN10314.1 - 0.00024 21.0 2.5 0.00049 20.1 2.5 1.5 1 0 0 1 1 1 1 Zinc knuckle gag_pre-integrs PF13976.6 EDN10314.1 - 0.0013 18.6 0.3 0.0039 17.0 0.0 2.0 2 0 0 2 2 2 1 GAG-pre-integrase domain DUF3435 PF11917.8 EDN10315.1 - 3.6e-144 480.8 20.4 4.1e-143 477.3 9.3 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3435) bZIP_2 PF07716.15 EDN10315.1 - 5.1e-06 26.5 10.1 5.1e-06 26.5 10.1 3.2 3 0 0 3 3 3 1 Basic region leucine zipper Phage_integrase PF00589.22 EDN10315.1 - 0.00011 22.0 0.2 0.021 14.6 0.0 2.8 2 0 0 2 2 2 2 Phage integrase family Elongin_A PF06881.11 EDN10315.1 - 2.2 8.8 8.3 1 9.9 0.3 2.9 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Rap1a PF18602.1 EDN10316.1 - 0.13 12.6 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 Rap1a immunity proteins Mito_carr PF00153.27 EDN10317.1 - 7.5e-57 189.3 1.6 8.9e-20 70.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2115 PF09888.9 EDN10319.1 - 0.14 12.7 4.2 0.21 12.1 4.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Vfa1 PF08432.10 EDN10319.1 - 1.9 8.8 17.5 3.2 8.1 17.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FliL PF03748.14 EDN10319.1 - 3.4 8.3 10.3 6.6 7.4 10.0 1.7 1 1 0 1 1 1 0 Flagellar basal body-associated protein FliL SAPS PF04499.15 EDN10319.1 - 3.6 6.3 9.0 4.5 5.9 9.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 EDN10319.1 - 5.9 5.1 13.6 7 4.8 13.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Prefoldin_2 PF01920.20 EDN10320.1 - 2e-19 69.5 3.7 2.5e-19 69.2 3.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit BLOC1_2 PF10046.9 EDN10320.1 - 0.0023 18.2 1.9 0.024 14.9 0.2 2.2 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 CCDC-167 PF15188.6 EDN10320.1 - 0.018 15.4 2.8 0.037 14.3 2.8 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Syntaxin-6_N PF09177.11 EDN10320.1 - 0.13 12.8 1.2 0.38 11.3 0.9 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal SoxG PF04268.12 EDN10320.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family DUF1664 PF07889.12 EDN10320.1 - 0.26 11.4 0.2 0.26 11.4 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlxA PF14282.6 EDN10320.1 - 0.72 9.9 6.9 2.3 8.3 2.4 2.2 2 0 0 2 2 2 0 FlxA-like protein YabA PF06156.13 EDN10320.1 - 2 9.1 6.6 32 5.2 6.6 2.1 1 1 0 1 1 1 0 Initiation control protein YabA Spc24 PF08286.11 EDN10320.1 - 3.2 8.0 5.7 17 5.7 0.6 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.10 EDN10320.1 - 3.7 7.7 7.7 7.8 6.7 5.6 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Ceramidase PF05875.12 EDN10322.1 - 2.5e-81 273.0 15.7 2e-78 263.4 9.4 2.0 1 1 1 2 2 2 2 Ceramidase Peptidase_U4 PF03419.13 EDN10322.1 - 0.65 9.2 7.6 0.94 8.7 6.8 1.6 1 1 1 2 2 2 0 Sporulation factor SpoIIGA DUF202 PF02656.15 EDN10322.1 - 4.9 7.7 10.1 1.8 9.1 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF202) DUF2157 PF09925.9 EDN10322.1 - 5.9 6.7 10.4 10 5.9 7.3 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Abhydrolase_6 PF12697.7 EDN10323.1 - 3.6e-12 47.4 3.4 1.7e-11 45.1 3.4 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN10323.1 - 5.1e-08 32.5 0.0 7.8e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EDN10323.1 - 0.011 14.6 0.0 0.02 13.8 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 EDN10323.1 - 0.028 14.1 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold DJ-1_PfpI PF01965.24 EDN10325.1 - 3.1e-10 40.1 0.0 1.3e-09 38.1 0.0 2.0 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EDN10325.1 - 0.00051 19.8 0.0 0.0024 17.6 0.0 1.9 1 1 0 1 1 1 1 ThiJ/PfpI family-like GATase_3 PF07685.14 EDN10325.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain ADH_N PF08240.12 EDN10326.1 - 3.1e-20 72.1 3.1 6.4e-20 71.1 3.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN10326.1 - 1.1e-14 54.5 0.0 1.9e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDN10326.1 - 0.00027 20.3 0.2 0.0011 18.3 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDN10326.1 - 0.00042 19.7 0.1 0.00071 19.0 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EDN10326.1 - 0.12 13.0 0.1 0.4 11.3 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EDN10326.1 - 0.16 11.9 0.2 0.23 11.3 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 EDN10327.1 - 8.1e-08 31.9 0.0 4.7e-05 22.9 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 EDN10327.1 - 0.049 12.4 0.0 0.067 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PTCB-BRCT PF12738.7 EDN10328.1 - 7.1e-26 89.9 3.1 2e-20 72.5 0.5 3.5 4 0 0 4 4 4 2 twin BRCT domain RTT107_BRCT_5 PF16770.5 EDN10328.1 - 9.2e-19 67.2 0.0 3.5e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EDN10328.1 - 8.8e-18 64.5 0.0 2.6e-09 37.3 0.0 4.7 4 1 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDN10328.1 - 4.6e-15 55.8 0.1 0.0017 18.7 0.0 4.4 4 0 0 4 4 4 4 BRCT domain, a BRCA1 C-terminus domain ESCRT-II PF05871.12 EDN10329.1 - 4.6e-54 182.5 0.1 6.2e-54 182.0 0.1 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit DDE_1 PF03184.19 EDN10330.1 - 7.9e-30 103.8 0.0 3.5e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN10330.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Methyltransf_4 PF02390.17 EDN10331.1 - 1.3e-44 151.7 0.6 1.7e-30 105.7 0.4 3.1 2 1 0 2 2 2 2 Putative methyltransferase MTS PF05175.14 EDN10331.1 - 0.0023 17.5 0.0 0.093 12.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDN10331.1 - 0.0023 18.6 0.0 0.014 16.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain DUF4191 PF13829.6 EDN10331.1 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4191) Methyltransf_12 PF08242.12 EDN10331.1 - 0.033 14.9 0.0 0.11 13.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 EDN10331.1 - 0.046 13.5 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EDN10331.1 - 0.089 13.5 0.0 2.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain LIM PF00412.22 EDN10332.1 - 2.3e-27 95.0 26.9 2.3e-10 40.5 1.4 4.0 3 1 0 3 3 3 3 LIM domain DUF2321 PF10083.9 EDN10332.1 - 0.012 15.2 1.0 0.012 15.2 1.0 3.1 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) Zn_ribbon_recom PF13408.6 EDN10332.1 - 0.014 15.8 0.2 0.014 15.8 0.2 3.5 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain MFS_1 PF07690.16 EDN10333.1 - 4.6e-15 55.4 41.2 3.2e-14 52.6 41.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Rrp44_S1 PF17215.3 EDN10334.1 - 2.4e-27 94.7 0.3 3.7e-27 94.1 0.3 1.3 1 0 0 1 1 1 1 S1 domain RNB PF00773.19 EDN10334.1 - 1.1e-14 54.5 0.2 1.5e-14 54.1 0.2 1.2 1 0 0 1 1 1 1 RNB domain Dis3l2_C_term PF17877.1 EDN10334.1 - 0.16 12.3 0.2 0.4 11.0 0.2 1.6 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal RNB PF00773.19 EDN10335.1 - 1.3e-46 159.5 0.5 2.4e-46 158.6 0.0 1.6 2 0 0 2 2 2 1 RNB domain Rrp44_CSD1 PF17216.3 EDN10335.1 - 1.8e-29 102.4 0.1 9.1e-29 100.1 0.1 2.0 1 1 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 EDN10335.1 - 7.6e-21 73.9 0.0 1.7e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EDN10335.1 - 1.8e-09 37.6 0.1 1.5e-06 28.3 0.0 2.7 2 1 0 2 2 2 2 Cold shock domain SUIM_assoc PF16619.5 EDN10336.1 - 2.4 8.3 13.8 5.9 7.0 13.8 1.7 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 ESSS PF10183.9 EDN10337.1 - 9.2e-16 58.0 0.0 1.1e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ATP-synt_E PF05680.12 EDN10337.1 - 0.12 12.7 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 ATP synthase E chain Acyl-CoA_ox_N PF14749.6 EDN10338.1 - 9.3e-17 61.7 0.6 1.1e-16 61.5 0.6 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Sec20 PF03908.13 EDN10338.1 - 0.0099 15.8 2.3 0.027 14.4 1.1 2.0 1 1 1 2 2 2 1 Sec20 DUF1825 PF08855.10 EDN10338.1 - 0.028 14.3 0.9 0.039 13.9 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) AIP3 PF03915.13 EDN10340.1 - 1.6e-119 399.7 0.3 1.3e-118 396.7 0.0 2.3 2 0 0 2 2 2 1 Actin interacting protein 3 T2SSF PF00482.23 EDN10340.1 - 0.012 15.6 0.6 0.055 13.4 0.0 2.4 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F MIP-T3_C PF17749.1 EDN10340.1 - 0.024 14.6 0.2 0.024 14.6 0.2 2.5 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region Med11 PF10280.9 EDN10340.1 - 0.04 14.4 0.0 0.2 12.1 0.0 2.3 1 0 0 1 1 1 0 Mediator complex protein CAS_CSE1 PF03378.15 EDN10340.1 - 0.13 10.7 0.2 0.27 9.7 0.2 1.4 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus NPV_P10 PF05531.12 EDN10340.1 - 2.8 8.5 4.6 3 8.4 0.0 3.3 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein RasGAP_C PF03836.15 EDN10340.1 - 9.1 6.4 9.8 1.1 9.5 0.4 3.6 5 0 0 5 5 5 0 RasGAP C-terminus SM-ATX PF14438.6 EDN10342.1 - 1.2e-23 83.1 0.0 2.1e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.13 EDN10342.1 - 7.4e-12 45.6 0.2 1.4e-11 44.8 0.2 1.4 1 0 0 1 1 1 1 LsmAD domain HEAT PF02985.22 EDN10345.1 - 1.5e-05 24.8 1.8 0.14 12.5 0.0 4.9 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EDN10345.1 - 1.9e-05 24.8 0.0 8.7e-05 22.6 0.0 1.9 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDN10345.1 - 7.2e-05 23.2 0.3 0.69 10.5 0.2 3.7 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.6 EDN10345.1 - 0.0022 18.3 0.2 0.17 12.3 0.2 3.0 1 1 3 4 4 4 2 HEAT repeats Pkinase PF00069.25 EDN10345.1 - 0.17 11.2 0.0 0.42 9.9 0.0 1.5 1 1 0 1 1 1 0 Protein kinase domain adh_short_C2 PF13561.6 EDN10346.1 - 0.0036 16.9 0.0 0.0036 16.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Macoilin PF09726.9 EDN10348.1 - 0.17 10.4 28.2 0.21 10.1 28.2 1.1 1 0 0 1 1 1 0 Macoilin family Chorion_2 PF03964.15 EDN10348.1 - 0.29 12.0 21.4 9.1 7.2 21.0 3.3 1 1 0 1 1 1 0 Chorion family 2 Miga PF10265.9 EDN10348.1 - 1.6 7.6 13.6 2.5 7.0 13.6 1.3 1 0 0 1 1 1 0 Mitoguardin Secretin_N_2 PF07655.13 EDN10348.1 - 4.4 7.9 19.3 0.43 11.1 12.7 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Borrelia_P83 PF05262.11 EDN10348.1 - 5.5 5.4 17.2 8.6 4.7 17.2 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein adh_short_C2 PF13561.6 EDN10349.1 - 6.5e-41 140.4 0.2 7.7e-41 140.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN10349.1 - 5.9e-36 123.8 0.0 8.5e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN10349.1 - 0.0012 18.8 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 KR domain APG6_N PF17675.1 EDN10350.1 - 0.05 14.1 1.3 0.13 12.8 1.3 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region WD40 PF00400.32 EDN10351.1 - 6.4e-36 121.8 17.2 1.4e-10 41.6 0.2 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10351.1 - 1.7e-10 41.1 1.0 0.052 13.8 0.1 4.4 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN10351.1 - 1.2e-07 30.8 2.6 0.044 12.4 0.0 4.8 4 1 0 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDN10351.1 - 1.8e-05 23.9 0.2 0.59 9.0 0.1 4.2 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EDN10351.1 - 1.9e-05 23.8 1.8 0.00013 21.0 0.1 2.6 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Hira PF07569.11 EDN10351.1 - 0.012 15.3 0.9 2.1 8.0 0.1 3.2 2 1 1 3 3 3 0 TUP1-like enhancer of split Frtz PF11768.8 EDN10351.1 - 0.035 12.4 0.0 0.069 11.5 0.0 1.4 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 EDN10351.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Tctex-1 PF03645.13 EDN10352.1 - 6.4e-36 122.7 0.0 7.6e-36 122.5 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family CYYR1 PF10873.8 EDN10352.1 - 0.1 13.1 0.1 0.14 12.6 0.1 1.3 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 DUF5521 PF17659.1 EDN10353.1 - 0.27 9.0 0.6 0.42 8.4 0.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF4602 PF15375.6 EDN10354.1 - 0.1 12.9 0.7 0.1 12.9 0.7 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4602) MGC-24 PF05283.11 EDN10355.1 - 3.3 8.2 15.0 9.5 6.7 13.7 1.9 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Med3 PF11593.8 EDN10355.1 - 9.5 5.3 11.2 14 4.7 11.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal HECT PF00632.25 EDN10356.1 - 1.5e-97 326.8 0.1 2.1e-97 326.3 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EDN10356.1 - 2.4e-34 117.1 22.7 1.9e-12 47.0 3.3 4.1 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EDN10356.1 - 2.5e-16 59.8 0.0 6.3e-16 58.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain TFIIA PF03153.13 EDN10356.1 - 2.3 8.1 6.5 3.4 7.6 6.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BPS1 PF05633.11 EDN10358.1 - 0.098 11.6 0.2 0.12 11.4 0.2 1.0 1 0 0 1 1 1 0 Protein BYPASS1-related Aminotran_5 PF00266.19 EDN10359.1 - 9.5e-10 38.0 0.0 1.2e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Myosin_head PF00063.21 EDN10362.1 - 1.2e-168 562.4 0.4 1.6e-168 562.0 0.4 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EDN10362.1 - 6.4e-39 133.6 0.0 1.4e-38 132.5 0.0 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 EDN10362.1 - 0.0082 15.8 9.7 0.6 10.1 1.0 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif OPA3 PF07047.12 EDN10363.1 - 6.3e-22 77.7 1.1 1.1e-21 76.9 1.1 1.4 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF4472 PF14739.6 EDN10363.1 - 0.14 12.9 0.5 0.14 12.9 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) COX16 PF14138.6 EDN10363.1 - 1.7 9.2 5.1 0.71 10.4 0.3 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Pkinase PF00069.25 EDN10364.1 - 7.6e-56 189.4 0.1 2.2e-55 187.9 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10364.1 - 1.9e-36 125.7 0.0 3.5e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EDN10364.1 - 3.3e-07 30.4 0.1 0.05 13.8 0.0 2.8 2 0 0 2 2 2 2 POLO box duplicated region Kdo PF06293.14 EDN10364.1 - 0.039 13.3 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDN10364.1 - 0.046 13.0 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EDN10364.1 - 0.047 12.6 0.1 0.082 11.8 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain 2-Hacid_dh_C PF02826.19 EDN10365.1 - 5.9e-39 133.2 0.0 2.6e-26 92.1 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1965 PF09248.10 EDN10365.1 - 0.012 15.3 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) TrkA_TMD PF18613.1 EDN10365.1 - 0.016 14.6 0.5 0.031 13.7 0.5 1.4 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain 3HCDH_N PF02737.18 EDN10365.1 - 0.099 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 EDN10365.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Gp_dh_N PF00044.24 EDN10365.1 - 0.12 12.7 0.2 0.31 11.4 0.2 1.7 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDN10365.1 - 0.17 11.5 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain RVT_1 PF00078.27 EDN10366.1 - 3.9e-32 111.6 0.0 1.3e-31 109.9 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN10366.1 - 0.00076 19.3 0.0 0.0029 17.4 0.0 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-RVT PF13966.6 EDN10366.1 - 0.12 13.1 1.2 0.36 11.6 0.3 2.3 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase CDC45 PF02724.14 EDN10367.1 - 0.48 8.7 2.0 0.47 8.7 2.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EDN10367.1 - 1.7 7.9 8.0 2.2 7.5 8.0 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EDN10367.1 - 5.8 4.9 9.5 7.1 4.6 9.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF2985 PF11204.8 EDN10368.1 - 2.1e-37 127.1 2.8 3.5e-37 126.4 2.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) BUD22 PF09073.10 EDN10371.1 - 1.9 7.8 6.5 2.5 7.3 6.5 1.1 1 0 0 1 1 1 0 BUD22 Ribosomal_L24e PF01246.20 EDN10372.1 - 1.1e-29 102.4 6.4 1.1e-29 102.4 6.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e Pam16 PF03656.13 EDN10373.1 - 1.3e-07 31.7 0.2 2e-07 31.1 0.2 1.5 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 EDN10373.1 - 4.1e-05 23.6 0.0 6.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.6 EDN10373.1 - 0.19 11.4 4.8 0.095 12.3 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) G_glu_transpept PF01019.21 EDN10374.1 - 1.5e-128 429.8 0.0 1.9e-128 429.5 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase TPMT PF05724.11 EDN10377.1 - 1.7e-15 57.3 0.4 8.5e-14 51.7 0.4 2.0 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 EDN10377.1 - 0.00088 19.9 0.0 0.0014 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN10377.1 - 0.00091 19.9 0.0 0.0015 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN10377.1 - 0.0033 17.2 0.1 0.012 15.4 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 EDN10377.1 - 0.028 14.8 0.0 0.058 13.7 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase N2227 PF07942.12 EDN10377.1 - 0.03 13.5 0.0 0.04 13.1 0.0 1.1 1 0 0 1 1 1 0 N2227-like protein OTU PF02338.19 EDN10378.1 - 2.1e-21 76.7 0.0 6.2e-21 75.2 0.0 1.8 1 1 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EDN10378.1 - 2.6e-07 30.3 0.0 4.9e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 Peptidase C65 Otubain NfI_DNAbd_pre-N PF10524.9 EDN10378.1 - 0.011 15.5 0.7 0.36 10.7 0.0 2.4 2 0 0 2 2 2 0 Nuclear factor I protein pre-N-terminus Cep57_MT_bd PF06657.13 EDN10378.1 - 0.016 15.7 2.0 0.053 14.0 2.0 2.0 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.6 EDN10378.1 - 2.4 7.4 8.0 3.7 6.8 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) adh_short_C2 PF13561.6 EDN10379.1 - 6.1e-28 98.0 0.0 8.4e-20 71.3 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN10379.1 - 3.8e-16 59.1 0.0 5.1e-11 42.4 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDN10379.1 - 5.4e-05 23.2 0.0 7.6e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Eclosion PF04736.12 EDN10379.1 - 0.038 13.7 0.2 1.1 9.0 0.1 2.4 1 1 1 2 2 2 0 Eclosion hormone Trehalase PF01204.18 EDN10380.1 - 1.6e-149 499.0 0.0 2.1e-133 445.9 0.0 2.1 1 1 1 2 2 2 2 Trehalase Trehalase_Ca-bi PF07492.11 EDN10380.1 - 1.7e-16 59.6 0.3 3.1e-16 58.8 0.3 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain ICL PF00463.21 EDN10381.1 - 1e-186 621.5 15.9 8.1e-151 503.1 0.8 3.0 1 1 1 2 2 2 2 Isocitrate lyase family HNH_2 PF13391.6 EDN10383.1 - 1.2e-06 28.6 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 HNH endonuclease Fungal_trans PF04082.18 EDN10384.1 - 3.3e-19 69.0 3.1 1.2e-16 60.6 2.4 2.6 2 1 0 2 2 2 2 Fungal specific transcription factor domain Pkinase PF00069.25 EDN10386.1 - 1.3e-66 224.6 0.0 2e-66 224.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10386.1 - 1e-30 106.9 0.0 1.5e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN10386.1 - 0.014 14.4 0.0 0.026 13.5 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EDN10386.1 - 0.043 13.1 0.1 0.096 12.0 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2075 PF09848.9 EDN10386.1 - 0.15 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATG101 PF07855.12 EDN10386.1 - 0.17 11.9 0.2 0.61 10.1 0.2 1.8 1 1 0 1 1 1 0 Autophagy-related protein 101 APH PF01636.23 EDN10386.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.1 3 1 0 3 3 3 0 Phosphotransferase enzyme family Fungal_trans PF04082.18 EDN10387.1 - 1.3e-09 37.5 0.2 2.9e-09 36.4 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aldose_epim PF01263.20 EDN10389.1 - 1.3e-20 74.0 0.1 4e-12 46.1 0.1 2.0 2 0 0 2 2 2 2 Aldose 1-epimerase MFS_1 PF07690.16 EDN10390.1 - 1.6e-25 89.8 19.9 1.6e-25 89.8 19.9 2.1 1 1 0 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 EDN10390.1 - 0.00035 19.1 0.3 0.00035 19.1 0.3 1.7 2 0 0 2 2 2 1 Transmembrane secretion effector DAHP_synth_2 PF01474.16 EDN10391.1 - 4.1e-179 595.7 0.0 3.6e-161 536.5 0.0 2.0 1 1 1 2 2 2 2 Class-II DAHP synthetase family PTCB-BRCT PF12738.7 EDN10392.1 - 0.16 12.0 0.2 3.8 7.5 0.2 2.4 2 0 0 2 2 2 0 twin BRCT domain PLA2_B PF01735.18 EDN10393.1 - 3e-198 659.2 0.1 3.5e-198 659.0 0.1 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PSD3 PF07626.11 EDN10393.1 - 0.17 12.4 0.0 0.49 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) DDE_1 PF03184.19 EDN10394.1 - 2.4e-30 105.5 0.0 5.2e-30 104.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN10394.1 - 5.4e-11 42.4 0.0 1.7e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN10394.1 - 3.9e-07 29.7 0.1 7.9e-07 28.7 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN10394.1 - 0.00036 20.3 0.0 0.015 15.1 0.0 2.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Piwi PF02171.17 EDN10395.1 - 8.9e-77 258.3 0.0 1.2e-76 257.9 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoL2 PF16488.5 EDN10395.1 - 8.5e-10 38.8 0.1 2e-09 37.6 0.1 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EDN10395.1 - 5.3e-08 32.8 0.0 9.6e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EDN10395.1 - 0.012 15.9 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 Mid domain of argonaute Ribophorin_II PF05817.14 EDN10397.1 - 1e-22 80.5 0.2 1.2e-22 80.3 0.2 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF2157 PF09925.9 EDN10397.1 - 0.9 9.3 5.8 1.7 8.4 2.0 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) AT_hook PF02178.19 EDN10399.1 - 0.096 12.6 0.7 0.096 12.6 0.7 2.9 2 0 0 2 2 2 0 AT hook motif His_Phos_2 PF00328.22 EDN10400.1 - 3.6e-61 207.6 0.0 4.1e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) bZIP_2 PF07716.15 EDN10401.1 - 1.6e-05 24.9 10.0 2.6e-05 24.2 10.0 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDN10401.1 - 0.17 12.5 6.9 0.22 12.1 5.5 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor Aldedh PF00171.22 EDN10402.1 - 6.2e-176 585.5 0.9 7.4e-176 585.2 0.9 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDN10402.1 - 0.095 12.1 0.0 0.24 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) SpoIIAA-like PF11964.8 EDN10402.1 - 0.099 13.7 0.1 0.83 10.7 0.0 2.4 2 0 0 2 2 2 0 SpoIIAA-like DUF2188 PF09954.9 EDN10402.1 - 0.12 12.5 0.7 0.46 10.7 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Methyltransf_PK PF05891.12 EDN10403.1 - 3.5e-59 200.0 0.0 4.2e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EDN10403.1 - 0.0022 18.7 0.0 0.0045 17.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN10403.1 - 0.0092 16.6 0.0 0.016 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain EVE PF01878.18 EDN10404.1 - 7.3e-46 155.8 0.2 2.3e-44 150.9 0.2 2.3 1 1 0 1 1 1 1 EVE domain Podoplanin PF05808.11 EDN10404.1 - 6.4 6.9 6.0 10 6.2 6.0 1.4 1 0 0 1 1 1 0 Podoplanin Ndc1_Nup PF09531.10 EDN10404.1 - 7.4 5.1 6.9 8.6 4.9 6.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MFS_1 PF07690.16 EDN10405.1 - 2.3e-31 109.0 9.7 2.9e-31 108.7 9.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN10405.1 - 9.2e-11 41.3 1.1 1e-10 41.1 1.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EDN10405.1 - 1.4e-09 37.0 2.7 1.7e-09 36.7 2.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EDN10405.1 - 0.00059 19.2 6.6 0.00059 19.2 6.6 1.4 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB FAM70 PF14967.6 EDN10405.1 - 0.16 11.4 0.1 0.31 10.5 0.1 1.4 1 0 0 1 1 1 0 FAM70 protein DUF3784 PF12650.7 EDN10405.1 - 0.22 11.7 1.7 1.1 9.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) IncD PF17628.2 EDN10405.1 - 0.3 10.9 0.9 0.64 9.8 0.9 1.5 1 0 0 1 1 1 0 Inclusion membrane protein D AhpC-TSA PF00578.21 EDN10407.1 - 9e-28 96.7 0.0 1.3e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 EDN10407.1 - 7.7e-13 48.1 0.1 1.4e-12 47.3 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 EDN10407.1 - 1.6e-11 44.1 0.0 2e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin Kelch_6 PF13964.6 EDN10409.1 - 3.3e-06 27.2 0.5 0.36 11.2 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EDN10409.1 - 7.2e-06 25.9 0.1 0.64 10.1 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain BTB PF00651.31 EDN10409.1 - 0.0022 18.2 0.0 0.36 11.1 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.25 EDN10409.1 - 0.011 15.3 0.2 3.5 7.3 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 EDN10409.1 - 0.015 15.3 0.0 0.42 10.7 0.0 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 EDN10409.1 - 0.027 14.7 4.4 11 6.5 0.0 4.2 4 0 0 4 4 4 0 Galactose oxidase, central domain mRNA_triPase PF02940.15 EDN10410.1 - 3.2e-58 197.0 0.0 4.6e-58 196.5 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Acyl_transf_3 PF01757.22 EDN10411.1 - 2e-28 99.5 24.1 4.1e-15 55.7 13.9 2.1 2 0 0 2 2 2 2 Acyltransferase family WD40 PF00400.32 EDN10412.1 - 5e-13 49.3 6.1 0.00023 21.9 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat CTP_transf_like PF01467.26 EDN10413.1 - 0.00014 22.0 0.1 0.1 12.8 0.0 2.3 2 0 0 2 2 2 2 Cytidylyltransferase-like Zn_clus PF00172.18 EDN10415.1 - 3e-08 33.6 10.6 4.9e-08 33.0 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PQ-loop PF04193.14 EDN10417.1 - 2.1e-21 75.4 3.8 3.1e-11 42.9 0.8 2.5 2 0 0 2 2 2 2 PQ loop repeat Med8 PF10232.9 EDN10418.1 - 3e-64 216.8 0.0 3.5e-64 216.6 0.0 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 FCP1_C PF09309.10 EDN10418.1 - 0.21 11.5 1.2 0.31 10.9 1.2 1.2 1 0 0 1 1 1 0 FCP1, C-terminal EarP PF10093.9 EDN10418.1 - 0.25 10.4 0.1 0.32 10.0 0.1 1.1 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP PMC2NT PF08066.12 EDN10418.1 - 0.67 10.7 2.2 8.8 7.1 2.1 2.4 1 1 1 2 2 2 0 PMC2NT (NUC016) domain MFS_1 PF07690.16 EDN10419.1 - 1.3e-22 80.2 19.4 1.7e-22 79.8 19.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN10419.1 - 0.00037 19.5 5.8 0.00037 19.5 5.8 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 EDN10419.1 - 0.00049 18.8 8.4 0.03 12.9 0.1 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein Lpp-LpqN PF10738.9 EDN10420.1 - 0.034 13.6 0.1 0.067 12.7 0.0 1.4 2 0 0 2 2 2 0 Probable lipoprotein LpqN APH PF01636.23 EDN10421.1 - 0.0045 16.9 4.2 0.57 10.1 0.0 3.0 2 2 1 3 3 3 2 Phosphotransferase enzyme family DUF3336 PF11815.8 EDN10422.1 - 2.4e-34 118.0 0.4 5.2e-34 116.9 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDN10422.1 - 3.9e-21 76.2 0.4 1.5e-20 74.3 0.0 2.0 2 0 0 2 2 2 1 Patatin-like phospholipase Abhydrolase_6 PF12697.7 EDN10423.1 - 0.02 15.5 0.0 0.15 12.7 0.0 2.2 1 1 0 1 1 1 0 Alpha/beta hydrolase family ArsP_1 PF03773.13 EDN10423.1 - 0.049 12.8 0.3 0.077 12.1 0.3 1.2 1 0 0 1 1 1 0 Predicted permease DUF1854 PF08909.11 EDN10424.1 - 0.013 15.4 0.4 0.051 13.4 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1854) AKNA PF12443.8 EDN10424.1 - 0.54 11.0 5.4 0.74 10.5 1.2 2.4 2 0 0 2 2 2 0 AT-hook-containing transcription factor Fib_alpha PF08702.10 EDN10424.1 - 4.6 7.4 7.8 0.54 10.4 1.0 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4094 PF13334.6 EDN10424.1 - 4.8 7.7 9.7 0.95 9.9 1.5 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) Lectin_N PF03954.14 EDN10424.1 - 8.4 6.2 13.2 19 5.0 0.2 3.6 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain RPN2_C PF18004.1 EDN10425.1 - 9.6e-55 184.9 6.9 9.6e-55 184.9 6.9 1.9 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EDN10425.1 - 1.7e-34 116.5 16.9 6.7e-09 35.8 0.0 8.4 7 0 0 7 7 7 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDN10425.1 - 8.3e-21 74.2 1.8 1e-13 51.5 0.0 5.0 3 1 3 6 6 6 4 HEAT repeats HEAT PF02985.22 EDN10425.1 - 1.9e-06 27.6 0.1 1.8 9.0 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EDN10425.1 - 7.7e-06 26.3 0.1 0.00094 19.6 0.1 4.3 2 1 1 3 3 3 1 HEAT-like repeat Cnd1 PF12717.7 EDN10425.1 - 0.00027 21.0 0.0 0.0096 16.0 0.0 3.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EDN10425.1 - 0.00035 21.0 0.4 6.3 7.8 0.0 4.8 4 0 0 4 4 4 2 PBS lyase HEAT-like repeat Acyl-CoA_dh_1 PF00441.24 EDN10426.1 - 9e-41 139.6 0.3 1.2e-40 139.1 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDN10426.1 - 3e-21 75.4 0.1 5.5e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 EDN10426.1 - 6.1e-17 61.5 0.1 1.1e-16 60.7 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 EDN10426.1 - 1.9e-13 51.1 0.0 4.6e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EDN10426.1 - 3.4e-10 40.3 0.0 5.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain C6 PF01681.17 EDN10426.1 - 0.041 14.4 0.1 0.66 10.5 0.1 2.6 2 0 0 2 2 2 0 C6 domain Spt5-NGN PF03439.13 EDN10427.1 - 8.1e-25 86.5 0.0 1.5e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section CTD PF12815.7 EDN10427.1 - 1.1e-18 67.6 39.7 6.2e-16 58.7 25.8 4.4 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 EDN10427.1 - 5.2e-18 65.9 9.0 5.2e-18 65.9 9.0 3.7 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 EDN10427.1 - 6.5e-13 48.1 13.9 0.0015 18.4 0.5 5.6 5 0 0 5 5 5 3 KOW motif DUF3912 PF13051.6 EDN10427.1 - 0.0064 16.7 4.0 0.037 14.3 0.0 3.2 4 0 0 4 4 4 1 Protein of unknown function (DUF3912) CS PF04969.16 EDN10428.1 - 1e-08 36.0 0.4 6.7e-08 33.4 0.4 2.2 1 1 0 1 1 1 1 CS domain tRNA-synt_2 PF00152.20 EDN10429.1 - 8.8e-87 291.1 0.0 1.2e-86 290.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EDN10429.1 - 0.045 13.7 0.0 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) FAD_binding_4 PF01565.23 EDN10430.1 - 0.0019 18.0 0.1 0.0028 17.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain PEP_mutase PF13714.6 EDN10431.1 - 2e-61 207.5 0.1 2.3e-61 207.3 0.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase APH PF01636.23 EDN10432.1 - 9.1e-09 35.6 0.0 1.5e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family HNH_2 PF13391.6 EDN10432.1 - 0.0003 20.9 0.0 0.0015 18.6 0.0 2.1 2 0 0 2 2 2 1 HNH endonuclease Choline_kinase PF01633.20 EDN10432.1 - 0.17 11.4 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase GMC_oxred_N PF00732.19 EDN10433.1 - 1.8e-27 96.5 0.0 2.7e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDN10433.1 - 1.2e-18 68.0 0.0 2.3e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase CBM_11 PF03425.13 EDN10433.1 - 0.04 13.8 0.2 0.067 13.1 0.2 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Mesd PF10185.9 EDN10433.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor ABC_tran PF00005.27 EDN10434.1 - 1.4e-40 138.9 0.0 1e-22 81.1 0.1 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDN10434.1 - 1.8e-38 132.8 31.8 7.7e-26 91.3 11.8 3.6 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EDN10434.1 - 4.9e-11 42.5 1.7 0.00014 21.4 0.1 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EDN10434.1 - 7.6e-05 23.0 0.1 0.49 10.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDN10434.1 - 0.00012 21.7 0.6 0.085 12.6 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDN10434.1 - 0.00035 20.6 0.1 0.09 12.9 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EDN10434.1 - 0.00051 20.6 0.1 0.063 13.8 0.1 2.8 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 EDN10434.1 - 0.001 19.0 0.0 2.2 8.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDN10434.1 - 0.0054 17.1 0.3 1 9.7 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 EDN10434.1 - 0.02 13.9 0.0 0.039 12.9 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 EDN10434.1 - 0.033 14.3 5.6 0.82 9.7 0.2 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain T2SSE PF00437.20 EDN10434.1 - 0.034 13.2 0.0 3.4 6.6 0.1 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EDN10434.1 - 0.061 12.6 0.2 4.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 EDN10434.1 - 0.061 13.0 0.6 1.4 8.6 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_10 PF12846.7 EDN10434.1 - 0.061 12.2 0.0 1.8 7.4 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain AIG1 PF04548.16 EDN10434.1 - 0.14 11.4 0.0 5.3 6.3 0.0 2.4 2 0 0 2 2 2 0 AIG1 family RNA_helicase PF00910.22 EDN10434.1 - 0.17 12.3 0.0 11 6.4 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 EDN10434.1 - 0.23 11.2 1.0 5.7 6.6 0.2 2.5 2 1 0 2 2 2 0 AAA domain CbiA PF01656.23 EDN10434.1 - 2.3 8.3 4.2 48 4.0 0.2 3.1 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF3403 PF11883.8 EDN10435.1 - 0.18 11.9 0.1 0.38 10.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3403) Peptidase_M28 PF04389.17 EDN10436.1 - 7.2e-31 107.4 0.0 9.9e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 GET2 PF08690.10 EDN10437.1 - 0.11 12.1 1.8 0.14 11.8 1.8 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Rhodanese PF00581.20 EDN10438.1 - 3.5e-05 24.3 0.0 5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain MutS_V PF00488.21 EDN10439.1 - 3e-67 226.3 0.1 5.5e-67 225.4 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDN10439.1 - 1.8e-42 145.8 0.3 4.8e-42 144.3 0.0 1.9 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EDN10439.1 - 7.5e-33 113.2 0.1 2.2e-32 111.6 0.0 1.9 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 EDN10439.1 - 1.6e-15 57.2 0.2 3.3e-15 56.2 0.2 1.6 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EDN10439.1 - 7e-12 45.8 0.0 3.1e-11 43.7 0.0 2.2 1 1 0 1 1 1 1 MutS domain II AAA_23 PF13476.6 EDN10439.1 - 0.00056 20.5 4.3 0.002 18.7 0.1 3.1 3 0 0 3 3 3 1 AAA domain AAA_27 PF13514.6 EDN10439.1 - 0.0039 16.8 0.0 0.0089 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EDN10439.1 - 0.04 13.7 0.2 0.12 12.1 0.2 1.9 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDN10439.1 - 0.049 13.4 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Filament PF00038.21 EDN10439.1 - 0.12 11.9 0.8 0.25 10.9 0.8 1.4 1 0 0 1 1 1 0 Intermediate filament protein tRNA-synt_1b PF00579.25 EDN10440.1 - 5.6e-67 226.1 0.0 7.3e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EDN10440.1 - 2.4e-26 91.9 0.0 6.4e-26 90.5 0.0 1.7 2 0 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain Acetyltransf_6 PF13480.7 EDN10440.1 - 0.021 15.0 0.1 0.043 14.0 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain S4 PF01479.25 EDN10440.1 - 0.04 13.6 0.5 0.24 11.2 0.0 2.4 3 0 0 3 3 3 0 S4 domain Raffinose_syn PF05691.12 EDN10441.1 - 9.9e-53 179.0 4.4 1.1e-50 172.3 4.4 2.5 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.18 EDN10441.1 - 0.00019 20.5 0.2 0.00032 19.7 0.2 1.2 1 0 0 1 1 1 1 Melibiase Aldedh PF00171.22 EDN10442.1 - 1.4e-162 541.4 0.1 1.6e-162 541.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDN10442.1 - 0.065 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) DUF2263 PF10021.9 EDN10443.1 - 1.3e-25 90.5 0.0 2.1e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) RRN9 PF10680.9 EDN10444.1 - 9.9e-24 83.4 0.3 9.9e-24 83.4 0.3 2.3 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor Pescadillo_N PF06732.11 EDN10445.1 - 1.2e-122 408.8 0.1 1.2e-122 408.8 0.1 1.9 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EDN10445.1 - 0.00022 21.6 0.0 0.001 19.4 0.0 2.1 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EDN10445.1 - 0.0023 18.3 0.0 0.078 13.4 0.0 3.1 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain CpeT PF06206.11 EDN10446.1 - 0.032 14.2 0.0 0.035 14.1 0.0 1.0 1 0 0 1 1 1 0 CpeT/CpcT family (DUF1001) Acetyltransf_1 PF00583.25 EDN10447.1 - 5.7e-13 49.1 0.0 9.2e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN10447.1 - 1.9e-06 27.8 0.1 4.6e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN10447.1 - 4.5e-06 27.0 0.2 7.6e-06 26.3 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN10447.1 - 0.00052 19.9 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein HIG_1_N PF04588.13 EDN10448.1 - 2.6e-20 72.4 0.0 3.5e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region MAS20 PF02064.15 EDN10448.1 - 0.01 15.9 4.2 0.016 15.3 4.2 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor DUF2971 PF11185.8 EDN10448.1 - 0.045 14.9 0.4 0.086 14.0 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2971) DUF4913 PF16259.5 EDN10448.1 - 0.046 13.8 0.1 0.085 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) RPN2_C PF18004.1 EDN10449.1 - 0.018 14.9 2.6 0.02 14.8 2.6 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 EDN10449.1 - 0.034 13.8 2.1 0.035 13.8 2.1 1.2 1 0 0 1 1 1 0 FAM176 family DUF3682 PF12446.8 EDN10449.1 - 0.046 14.2 5.8 0.058 13.9 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) NOA36 PF06524.12 EDN10449.1 - 0.2 11.0 6.4 0.21 10.8 6.4 1.1 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 EDN10449.1 - 0.2 11.5 7.1 0.21 11.4 7.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ribosomal_60s PF00428.19 EDN10449.1 - 0.22 12.2 6.9 0.25 12.0 6.9 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Radial_spoke PF04712.12 EDN10449.1 - 0.22 10.4 5.7 0.22 10.4 5.7 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Sporozoite_P67 PF05642.11 EDN10449.1 - 0.33 9.0 3.8 0.38 8.8 3.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 EDN10449.1 - 0.8 7.9 3.9 0.79 7.9 3.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.11 EDN10449.1 - 1.1 8.1 6.1 1.3 7.8 6.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DNA_pol_phi PF04931.13 EDN10449.1 - 2.1 6.3 8.7 2.3 6.2 8.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi Adeno_terminal PF02459.15 EDN10449.1 - 6.5 5.0 9.8 7.3 4.9 9.8 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein PALP PF00291.25 EDN10450.1 - 7.9e-57 192.9 1.1 1.3e-56 192.2 1.1 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EDN10450.1 - 7.4e-43 144.2 0.0 7.9e-21 73.6 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase NLE PF08154.12 EDN10450.1 - 0.093 13.3 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 NLE (NUC135) domain IMS PF00817.20 EDN10450.1 - 0.13 12.2 0.0 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 impB/mucB/samB family GTP_EFTU PF00009.27 EDN10452.1 - 2.6e-55 187.0 0.8 3.4e-55 186.6 0.8 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EDN10452.1 - 0.0056 16.5 0.1 0.026 14.3 0.1 2.1 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EDN10452.1 - 0.052 13.6 0.0 0.13 12.4 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Abhydrolase_6 PF12697.7 EDN10453.1 - 2.7e-11 44.5 4.6 2.7e-11 44.5 4.6 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN10453.1 - 9.4e-08 31.6 0.0 1.4e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDN10453.1 - 0.00015 21.5 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EDN10453.1 - 0.00066 19.6 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.12 EDN10453.1 - 0.058 12.3 0.0 0.084 11.8 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) TLD PF07534.16 EDN10455.1 - 1.5e-19 70.6 0.0 2.8e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 EDN10455.1 - 0.00086 20.3 1.0 0.0037 18.3 1.0 2.2 1 1 0 1 1 1 1 Domain of unknown function NMT_C PF02799.15 EDN10456.1 - 3.3e-87 291.4 0.0 6.6e-87 290.4 0.0 1.5 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EDN10456.1 - 7.3e-72 240.4 0.0 1.1e-71 239.8 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EDN10456.1 - 3.8e-06 27.0 0.0 3.3e-05 24.0 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN10456.1 - 0.096 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family NTP_transf_9 PF04248.12 EDN10456.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF427) Mur_ligase_M PF08245.12 EDN10457.1 - 2.4e-06 27.7 0.1 0.00018 21.6 0.1 2.9 1 1 0 1 1 1 1 Mur ligase middle domain Syja_N PF02383.18 EDN10458.1 - 5.5e-90 301.9 0.1 7.3e-90 301.5 0.1 1.1 1 0 0 1 1 1 1 SacI homology domain Ras PF00071.22 EDN10459.1 - 2.2e-47 160.7 0.5 2.5e-47 160.5 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN10459.1 - 2.4e-25 89.1 0.4 5.7e-25 87.9 0.3 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN10459.1 - 8e-11 41.7 0.1 9.4e-11 41.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN10459.1 - 2.1e-06 27.4 0.1 2.6e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN10459.1 - 0.00024 20.5 0.0 0.0003 20.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EDN10459.1 - 0.031 14.2 0.1 0.07 13.0 0.1 1.5 1 1 1 2 2 2 0 RsgA GTPase GbpA_2 PF18416.1 EDN10459.1 - 0.11 12.7 0.7 4.1 7.8 0.0 2.2 1 1 1 2 2 2 0 N-acetylglucosamine binding protein domain 2 MCR_beta PF02241.18 EDN10459.1 - 0.13 11.8 0.1 0.46 10.1 0.0 1.7 1 1 1 2 2 2 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain Mitofilin PF09731.9 EDN10460.1 - 1.9e-169 565.5 40.1 2.6e-136 456.0 28.0 2.3 2 1 1 3 3 3 2 Mitochondrial inner membrane protein Ribosomal_L20 PF00453.18 EDN10460.1 - 0.0085 16.2 1.3 0.021 14.9 1.3 1.7 1 0 0 1 1 1 1 Ribosomal protein L20 DUF4363 PF14276.6 EDN10460.1 - 0.13 12.4 6.4 0.41 10.8 0.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4363) Focal_AT PF03623.13 EDN10460.1 - 0.21 11.6 3.0 0.36 10.8 0.2 2.6 1 1 1 2 2 2 0 Focal adhesion targeting region ArnB_C PF18677.1 EDN10460.1 - 0.42 10.8 13.2 4.1 7.6 2.6 4.2 4 0 0 4 4 4 0 Archaellum regulatory network B, C-terminal domain SPX PF03105.19 EDN10460.1 - 5.2 6.9 21.3 4 7.2 8.7 2.2 2 0 0 2 2 2 0 SPX domain Gp58 PF07902.11 EDN10461.1 - 0.014 13.7 0.1 0.022 13.1 0.1 1.1 1 0 0 1 1 1 0 gp58-like protein DUF1179 PF06678.11 EDN10461.1 - 0.16 12.0 0.8 0.94 9.5 0.8 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) DSBA PF01323.20 EDN10463.1 - 8e-07 29.0 0.0 8.7e-07 28.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF4695 PF15766.5 EDN10464.1 - 2.4 8.4 8.9 2.5 8.4 6.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4695) Methyltransf_16 PF10294.9 EDN10465.1 - 1.8e-48 164.6 0.0 2.4e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EDN10465.1 - 1.3e-06 28.4 0.0 2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN10465.1 - 2.1e-06 27.6 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN10465.1 - 0.0003 21.4 0.0 0.0006 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDN10465.1 - 0.0027 17.3 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EDN10465.1 - 0.0029 18.3 0.0 0.0064 17.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Orn_Arg_deC_N PF02784.16 EDN10466.1 - 5.9e-85 284.6 0.0 7.4e-85 284.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EDN10466.1 - 2.5e-18 66.1 0.0 3.1e-18 65.8 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EDN10466.1 - 0.014 14.9 0.0 0.033 13.6 0.0 1.6 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Rho_N PF07498.12 EDN10466.1 - 0.7 9.9 2.3 6.1 6.9 0.5 2.4 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain cobW PF02492.19 EDN10467.1 - 6.1e-40 136.7 0.0 1.5e-39 135.5 0.0 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EDN10467.1 - 0.026 14.4 0.0 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.6 EDN10467.1 - 0.092 12.5 0.1 1.9 8.3 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain CobW_C PF07683.14 EDN10467.1 - 0.11 12.4 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain SET PF00856.28 EDN10468.1 - 1.7e-07 31.8 0.0 2.7e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 SET domain Amdo_NSP PF12475.8 EDN10468.1 - 4.4 7.5 4.7 0.52 10.4 0.6 1.6 2 0 0 2 2 2 0 Amdovirus non-structural protein HATPase_c_3 PF13589.6 EDN10469.1 - 3.2e-08 33.5 0.1 2e-07 30.9 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EDN10469.1 - 3.6e-06 26.6 0.0 8.3e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 EDN10469.1 - 1.3e-05 25.7 0.0 3.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Abhydrolase_1 PF00561.20 EDN10471.1 - 8.5e-19 68.2 0.0 3.7e-17 62.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN10471.1 - 7.3e-13 49.6 11.7 1.3e-12 48.8 11.7 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 EDN10471.1 - 0.0047 15.7 0.0 0.007 15.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.8 EDN10471.1 - 0.024 13.9 0.0 0.18 11.1 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Methyltransf_16 PF10294.9 EDN10472.1 - 4.2e-08 33.1 0.0 4.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_31 PF13847.6 EDN10473.1 - 5.5e-10 39.2 0.0 4.8e-09 36.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN10473.1 - 1.3e-06 28.4 0.0 2.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN10473.1 - 6.1e-06 26.8 0.1 2.8e-05 24.7 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN10473.1 - 6.3e-05 23.6 0.1 0.00028 21.5 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN10473.1 - 0.0026 18.4 1.9 0.0086 16.8 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain MetW PF07021.12 EDN10473.1 - 0.0074 15.9 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Nop14 PF04147.12 EDN10473.1 - 0.085 11.1 6.5 0.13 10.4 6.5 1.3 1 0 0 1 1 1 0 Nop14-like family Methyltransf_32 PF13679.6 EDN10473.1 - 0.085 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DNA_pol_phi PF04931.13 EDN10473.1 - 0.097 10.8 9.4 0.14 10.2 9.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_3_Rpc31 PF11705.8 EDN10473.1 - 0.098 12.9 12.4 0.041 14.1 8.1 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 eIF-3c_N PF05470.12 EDN10473.1 - 0.23 9.7 0.3 0.29 9.4 0.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2201_N PF13203.6 EDN10473.1 - 3.1 7.3 6.5 2.9 7.4 0.0 2.6 2 1 0 2 2 2 0 Putative metallopeptidase domain NOA36 PF06524.12 EDN10473.1 - 3.5 6.9 11.9 7.1 5.9 11.9 1.5 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EDN10473.1 - 5.7 7.4 17.6 0.23 11.9 10.9 2.2 3 0 0 3 3 2 0 Centromere protein B dimerisation domain ECM1 PF05782.11 EDN10474.1 - 2.3 7.1 12.4 3.4 6.5 12.4 1.2 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Borrelia_P83 PF05262.11 EDN10474.1 - 8.6 4.7 24.8 12 4.3 24.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Rotamase_3 PF13616.6 EDN10476.1 - 5.4e-11 43.0 0.9 1.2e-10 42.0 0.3 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EDN10476.1 - 1.9e-09 38.3 0.0 3.7e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain UAA PF08449.11 EDN10477.1 - 1.4e-18 67.2 4.8 1.5e-18 67.0 4.8 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDN10477.1 - 2.9e-05 24.3 6.2 3.7e-05 23.9 6.2 1.3 1 1 0 1 1 1 1 EamA-like transporter family Nuc_sug_transp PF04142.15 EDN10477.1 - 0.04 13.1 0.0 0.049 12.8 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-sugar transporter VASt PF16016.5 EDN10478.1 - 1.7e-34 119.5 0.1 3.6e-34 118.4 0.1 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 EDN10478.1 - 2.3e-08 34.5 0.0 8.6e-08 32.6 0.0 2.1 1 0 0 1 1 1 1 PH domain GRAM PF02893.20 EDN10478.1 - 0.0051 16.7 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 GRAM domain BAR_3 PF16746.5 EDN10478.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 BAR domain of APPL family Kri1_C PF12936.7 EDN10479.1 - 4.1e-32 110.2 0.2 4.1e-32 110.2 0.2 4.7 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 EDN10479.1 - 6.4e-29 100.5 16.7 6.4e-29 100.5 16.7 5.7 6 2 0 6 6 6 1 KRI1-like family Mito_carr PF00153.27 EDN10480.1 - 2.5e-67 222.9 5.2 2.5e-25 88.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 EDN10480.1 - 0.05 13.4 1.0 0.15 11.8 1.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Stb3 PF10330.9 EDN10482.1 - 9.9e-38 128.1 0.0 1.7e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein PTS_2-RNA PF01885.16 EDN10483.1 - 7.2e-67 224.9 0.0 1e-66 224.4 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Utp13 PF08625.11 EDN10483.1 - 0.0073 16.2 0.4 0.21 11.5 0.4 2.4 1 1 0 1 1 1 1 Utp13 specific WD40 associated domain Mucin PF01456.17 EDN10483.1 - 7.4 6.6 25.9 22 5.1 25.9 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein Efg1 PF10153.9 EDN10484.1 - 9.4e-33 113.0 7.6 9.4e-33 113.0 7.6 2.0 2 0 0 2 2 2 1 rRNA-processing protein Efg1 LRR_6 PF13516.6 EDN10486.1 - 7.6e-09 34.9 6.5 0.43 10.8 0.0 6.0 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 EDN10486.1 - 0.017 15.6 9.8 6.5 7.3 0.0 5.4 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDN10486.1 - 0.056 14.0 19.4 3.7 8.5 0.2 6.2 6 1 0 6 6 6 0 Leucine Rich Repeat Pkinase PF00069.25 EDN10487.1 - 3.9e-58 196.9 0.0 5.8e-58 196.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10487.1 - 3e-21 75.9 0.0 4.9e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDN10487.1 - 1.4e-06 27.5 0.0 2.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDN10487.1 - 9.8e-06 25.1 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDN10487.1 - 6.7e-05 22.9 0.1 0.026 14.4 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN10487.1 - 0.00019 20.4 0.0 0.00029 19.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EDN10487.1 - 0.00026 20.6 0.6 0.00074 19.2 0.6 1.8 1 1 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.11 EDN10487.1 - 0.1 11.6 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RabGAP-TBC PF00566.18 EDN10488.1 - 6.8e-33 114.1 1.6 9.8e-33 113.6 1.6 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Yippee-Mis18 PF03226.14 EDN10490.1 - 6.8e-19 68.0 0.9 7.6e-19 67.9 0.9 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2039 PF10217.9 EDN10490.1 - 0.0019 18.5 1.6 0.01 16.2 0.2 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) DUF4451 PF14616.6 EDN10490.1 - 0.0021 18.3 0.4 0.0027 17.9 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) RIG-I_C-RD PF11648.8 EDN10490.1 - 0.022 15.0 1.4 0.03 14.5 1.4 1.3 1 0 0 1 1 1 0 C-terminal domain of RIG-I Endonuclease_7 PF02945.15 EDN10490.1 - 0.063 13.2 1.4 0.16 11.9 1.0 1.9 1 1 0 1 1 1 0 Recombination endonuclease VII KH_1 PF00013.29 EDN10492.1 - 4.7e-42 141.7 8.0 2.7e-17 62.4 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EDN10492.1 - 2.3e-09 36.9 9.6 0.011 15.5 0.6 3.4 3 1 0 3 3 3 3 KH domain KH_4 PF13083.6 EDN10492.1 - 2.6e-09 36.8 2.6 0.065 13.1 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EDN10492.1 - 0.00043 20.3 7.0 0.11 12.6 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain Epimerase PF01370.21 EDN10493.1 - 1.1e-18 67.6 0.0 1.6e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN10493.1 - 6.7e-14 51.6 0.0 9.9e-14 51.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDN10493.1 - 5.4e-10 38.9 0.1 1.6e-08 34.0 0.1 2.3 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDN10493.1 - 1.1e-08 34.9 0.0 2.4e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDN10493.1 - 2.8e-07 30.6 0.0 4.7e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EDN10493.1 - 8.9e-06 25.0 0.0 4.6e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDN10493.1 - 0.00015 21.0 0.0 0.00023 20.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EDN10493.1 - 0.00027 20.9 0.0 0.00048 20.1 0.0 1.4 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EDN10493.1 - 0.0033 17.0 0.3 0.014 14.9 0.2 2.1 2 1 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EDN10493.1 - 0.0052 16.3 0.0 0.012 15.1 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase F420_oxidored PF03807.17 EDN10493.1 - 0.0086 16.6 0.0 0.02 15.4 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PE-PPE PF08237.11 EDN10493.1 - 0.07 12.7 0.0 18 4.8 0.0 2.7 2 1 0 3 3 3 0 PE-PPE domain DAO PF01266.24 EDN10494.1 - 3.1e-20 73.1 0.0 3.7e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDN10494.1 - 0.045 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding GIDA PF01134.22 EDN10494.1 - 0.19 10.8 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Methyltransf_33 PF10017.9 EDN10495.1 - 3.1e-40 138.3 0.0 6.1e-33 114.3 0.0 2.0 2 0 0 2 2 2 2 Histidine-specific methyltransferase, SAM-dependent Nitr_red_bet_C PF14711.6 EDN10495.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal Fungal_trans_2 PF11951.8 EDN10496.1 - 1.2e-09 37.5 2.7 6.2e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Pterin_4a PF01329.19 EDN10499.1 - 9.7e-20 70.5 0.1 1.3e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase CdiI_2 PF18593.1 EDN10499.1 - 0.13 12.9 0.1 0.31 11.7 0.0 1.6 2 0 0 2 2 2 0 CdiI immunity protein Aminotran_3 PF00202.21 EDN10500.1 - 4.8e-36 124.3 0.1 6.3e-36 123.9 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DSPc PF00782.20 EDN10502.1 - 4.2e-23 81.6 0.0 1.2e-19 70.4 0.0 2.3 1 1 1 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDN10502.1 - 0.21 11.1 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Peptidase_S58 PF03576.14 EDN10503.1 - 5e-41 141.2 8.0 4.5e-40 138.0 8.0 1.9 1 1 0 1 1 1 1 Peptidase family S58 Ribosomal_L7Ae PF01248.26 EDN10505.1 - 8.5e-26 89.5 0.4 1.1e-25 89.2 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EDN10505.1 - 0.1 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Vac_ImportDeg PF09783.9 EDN10506.1 - 1.3e-21 77.1 0.5 3.6e-21 75.7 0.3 1.7 2 0 0 2 2 2 1 Vacuolar import and degradation protein DUF1833 PF08875.11 EDN10506.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1833) MR_MLE_C PF13378.6 EDN10507.1 - 3e-56 190.5 0.0 4.2e-56 190.0 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EDN10507.1 - 5.5e-12 45.9 0.4 5.2e-10 39.5 0.2 2.7 2 1 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain IU_nuc_hydro PF01156.19 EDN10508.1 - 2.9e-69 234.0 0.0 3.6e-69 233.7 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PXA PF02194.15 EDN10509.1 - 2.4e-44 151.5 1.0 3.1e-44 151.1 1.0 1.1 1 0 0 1 1 1 1 PXA domain DUF787 PF05619.11 EDN10509.1 - 0.19 10.9 0.0 0.27 10.3 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) HTH_Tnp_Tc5 PF03221.16 EDN10510.1 - 1.3e-15 57.2 0.3 2.3e-15 56.4 0.3 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EDN10510.1 - 2.4e-07 30.3 0.0 8.3e-07 28.6 0.0 1.9 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Crp_2 PF13545.6 EDN10510.1 - 0.0063 16.5 0.0 0.021 14.8 0.0 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain MarR PF01047.22 EDN10510.1 - 0.027 14.4 0.1 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 MarR family HTH_37 PF13744.6 EDN10510.1 - 0.039 13.9 0.0 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 EDN10510.1 - 0.058 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_23 PF13384.6 EDN10510.1 - 0.16 11.8 0.0 0.46 10.4 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Tnp_4 PF13613.6 EDN10510.1 - 0.18 11.6 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease RVT_2 PF07727.14 EDN10511.1 - 5.1e-48 163.8 0.0 2.2e-47 161.7 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN10511.1 - 1.4e-12 47.8 0.0 6e-12 45.8 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN10511.1 - 8.5e-08 32.0 0.0 2.8e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 EDN10511.1 - 0.063 13.1 0.0 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain eIF3g PF12353.8 EDN10511.1 - 0.079 13.4 6.5 0.26 11.7 6.5 1.8 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G RVT_3 PF13456.6 EDN10511.1 - 0.084 12.7 0.3 0.3 10.9 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase-like zf-CCHC PF00098.23 EDN10511.1 - 0.4 10.8 5.3 0.83 9.9 5.3 1.6 1 0 0 1 1 1 0 Zinc knuckle Cpn60_TCP1 PF00118.24 EDN10512.1 - 3.7e-131 438.1 14.1 4.5e-131 437.8 14.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA PF00004.29 EDN10513.1 - 6.2e-41 139.9 0.0 1.1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN10513.1 - 3.1e-05 23.7 0.0 7.8e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDN10513.1 - 7.2e-05 23.1 0.0 0.0059 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDN10513.1 - 9.8e-05 22.4 0.1 0.00043 20.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDN10513.1 - 0.00021 21.5 0.0 0.00069 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDN10513.1 - 0.0005 20.5 0.1 0.011 16.1 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EDN10513.1 - 0.0016 17.6 0.0 0.0029 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EDN10513.1 - 0.0085 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDN10513.1 - 0.024 14.9 0.1 0.063 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDN10513.1 - 0.035 13.6 0.0 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EDN10513.1 - 0.05 13.8 0.0 0.094 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN10513.1 - 0.057 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EDN10513.1 - 0.087 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDN10513.1 - 0.096 12.4 0.0 0.24 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDN10513.1 - 0.1 12.3 0.1 0.6 9.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDN10513.1 - 0.11 13.0 0.0 0.49 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EDN10513.1 - 0.14 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EDN10513.1 - 0.17 11.2 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FAD_binding_2 PF00890.24 EDN10514.1 - 4.2e-126 421.4 2.8 5.2e-126 421.1 2.8 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EDN10514.1 - 2.6e-45 153.5 0.7 3.9e-45 153.0 0.7 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EDN10514.1 - 3.5e-06 26.5 0.1 0.00084 18.7 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDN10514.1 - 4.6e-05 22.7 1.9 0.033 13.3 2.4 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EDN10514.1 - 5.1e-05 22.6 0.1 0.044 13.0 0.0 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EDN10514.1 - 0.003 16.9 0.2 0.0073 15.6 0.2 1.7 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDN10514.1 - 0.028 14.0 2.0 0.1 12.2 2.0 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EDN10514.1 - 0.17 10.5 1.6 0.76 8.4 0.6 2.5 3 0 0 3 3 3 0 HI0933-like protein DPPIV_N PF00930.21 EDN10515.1 - 3.4e-103 345.1 0.1 4.8e-103 344.6 0.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EDN10515.1 - 5.4e-57 192.7 1.8 3.8e-56 189.9 3.2 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EDN10515.1 - 0.00012 21.7 4.7 0.0011 18.6 3.2 2.3 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EDN10515.1 - 0.0071 16.0 0.2 0.017 14.8 0.2 1.5 1 1 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 EDN10515.1 - 0.012 15.4 0.1 5.8 6.7 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF4988 PF16378.5 EDN10515.1 - 0.021 14.5 0.0 0.061 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function PAF-AH_p_II PF03403.13 EDN10515.1 - 0.023 13.2 0.0 5.2 5.5 0.0 2.2 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DLH PF01738.18 EDN10515.1 - 0.034 13.7 0.0 0.12 11.9 0.0 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family PI-PLC-X PF00388.19 EDN10517.1 - 8.2e-64 213.6 0.0 1.3e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EDN10517.1 - 1.6e-41 141.3 0.1 2.7e-41 140.5 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain RTC4 PF14474.6 EDN10519.1 - 1.1e-26 93.3 0.1 2.2e-26 92.4 0.1 1.4 1 0 0 1 1 1 1 RTC4-like domain Myb_DNA-bind_6 PF13921.6 EDN10519.1 - 5.6e-06 26.5 0.2 1.2e-05 25.4 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN10519.1 - 0.00054 20.1 1.6 0.0012 19.0 1.6 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EDN10519.1 - 0.17 12.1 0.6 0.45 10.7 0.6 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Pkinase PF00069.25 EDN10520.1 - 3.8e-23 82.2 0.0 9.3e-17 61.2 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10520.1 - 1.3e-09 37.7 0.0 5.2e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDN10520.1 - 1.1e-05 24.9 0.2 0.037 13.4 0.0 3.0 2 1 1 3 3 3 3 Kinase-like APH PF01636.23 EDN10520.1 - 0.0054 16.7 0.2 0.057 13.3 0.2 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN10520.1 - 0.23 10.2 0.8 1.9 7.2 0.5 1.9 1 1 1 2 2 2 0 Fungal protein kinase DUF4690 PF15756.5 EDN10521.1 - 9.1 7.0 5.8 1.3 9.7 0.4 2.4 3 0 0 3 3 3 0 Small Novel Rich in Cartilage RAWUL PF16207.5 EDN10522.1 - 0.81 10.4 3.5 3 8.6 0.4 2.4 1 1 1 2 2 2 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like AAA PF00004.29 EDN10523.1 - 7.8e-18 65.2 0.0 1.7e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN10523.1 - 0.00046 20.6 0.1 0.0021 18.4 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDN10523.1 - 0.0014 18.7 0.0 0.0034 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN10523.1 - 0.0044 17.3 0.4 0.13 12.5 0.0 3.0 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 EDN10523.1 - 0.019 14.7 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDN10523.1 - 0.063 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EDN10523.1 - 0.1 13.0 0.0 0.35 11.3 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 EDN10523.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2205 PF10224.9 EDN10525.1 - 0.0001 22.2 0.1 0.00017 21.5 0.1 1.3 1 0 0 1 1 1 1 Short coiled-coil protein DUF1752 PF08550.10 EDN10526.1 - 6.7e-06 25.8 4.6 1.5e-05 24.8 4.6 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) AAA PF00004.29 EDN10528.1 - 2.3e-20 73.4 0.0 7.8e-20 71.6 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN10528.1 - 7.2e-05 23.2 0.1 0.00016 22.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDN10528.1 - 0.0049 17.4 0.7 1.1 9.8 0.0 3.2 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 EDN10528.1 - 0.026 14.5 0.0 0.1 12.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) BCS1_N PF08740.11 EDN10528.1 - 0.026 14.5 0.1 0.062 13.3 0.1 1.6 1 0 0 1 1 1 0 BCS1 N terminal PPV_E1_C PF00519.17 EDN10528.1 - 0.03 13.2 0.0 0.048 12.5 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase ATPase PF06745.13 EDN10528.1 - 0.035 13.4 0.0 0.065 12.6 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EDN10528.1 - 0.036 13.6 0.1 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDN10528.1 - 0.05 13.3 0.0 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EDN10528.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 EDN10528.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea HSDR_N_2 PF13588.6 EDN10529.1 - 0.005 16.8 0.0 0.95 9.5 0.0 2.5 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) DnaI_N PF07319.11 EDN10530.1 - 0.41 11.4 3.0 81 4.0 0.1 3.8 2 1 3 5 5 5 0 Primosomal protein DnaI N-terminus BUD22 PF09073.10 EDN10530.1 - 8 5.7 31.5 0.11 11.8 22.9 1.9 2 0 0 2 2 2 0 BUD22 Zn_clus PF00172.18 EDN10532.1 - 6.5e-08 32.6 8.7 6.5e-08 32.6 8.7 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos_2 PF14529.6 EDN10534.1 - 8.7e-11 41.7 0.0 1.5e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase MethyTransf_Reg PF10119.9 EDN10534.1 - 0.021 15.5 0.1 1.3 9.8 0.0 2.6 2 1 0 2 2 2 0 Predicted methyltransferase regulatory domain Retrotran_gag_3 PF14244.6 EDN10536.1 - 0.014 15.2 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 EDN10536.1 - 0.045 13.4 0.1 0.076 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Myb_DNA-binding PF00249.31 EDN10538.1 - 0.084 13.1 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF2200 PF09966.9 EDN10539.1 - 0.016 15.3 0.0 3 8.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2200) CDC37_C PF08564.10 EDN10539.1 - 0.046 13.8 0.3 0.077 13.1 0.3 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain DDE_1 PF03184.19 EDN10540.1 - 4.7e-23 81.7 0.0 1e-22 80.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN10540.1 - 3e-05 23.8 0.1 0.00066 19.5 0.0 2.7 2 2 1 3 3 3 1 DDE superfamily endonuclease Pox_VP8_L4R PF04498.12 EDN10540.1 - 0.055 13.1 0.0 2.4 7.7 0.1 2.6 2 1 0 2 2 2 0 Poxvirus nucleic acid binding protein VP8/L4R RR_TM4-6 PF06459.12 EDN10540.1 - 9.3 6.0 14.5 16 5.2 14.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDE_1 PF03184.19 EDN10541.1 - 1e-18 67.6 0.0 1.7e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN10541.1 - 0.0014 18.4 0.1 0.0032 17.3 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3656 PF12392.8 EDN10541.1 - 0.076 13.7 0.1 7.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Collagenase NUDE_C PF04880.13 EDN10541.1 - 0.16 12.4 2.7 0.24 11.9 2.7 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region OrsD PF12013.8 EDN10545.1 - 5.8e-38 129.8 5.5 5.8e-38 129.8 5.5 2.0 2 1 1 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDN10545.1 - 0.013 15.2 3.5 0.2 11.4 1.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF2225 PF09986.9 EDN10545.1 - 0.087 12.5 0.2 1.6 8.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF4298 PF14131.6 EDN10545.1 - 0.23 11.5 0.8 18 5.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) BRD4_CDT PF17105.5 EDN10545.1 - 0.24 11.0 2.6 0.32 10.6 0.5 2.2 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 CSRNP_N PF16019.5 EDN10547.1 - 1.2 9.0 4.6 0.21 11.5 0.8 1.6 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus LEA_1 PF03760.15 EDN10547.1 - 1.8 9.3 4.5 0.47 11.1 0.8 1.8 2 0 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 PBP1_TM PF14812.6 EDN10548.1 - 0.00027 21.3 1.8 0.00027 21.3 1.8 2.1 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EDN10548.1 - 1.4 9.4 13.3 3.3 8.2 13.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EDN10548.1 - 2.8 7.6 8.1 4.9 6.8 8.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EDN10548.1 - 3.8 6.7 9.0 5.8 6.2 9.0 1.2 1 0 0 1 1 1 0 NOA36 protein Sugar_tr PF00083.24 EDN10549.1 - 1.1e-11 44.4 1.5 1.4e-11 43.9 1.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN10549.1 - 4.1e-10 39.1 8.3 5.9e-10 38.6 8.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3792 PF12670.7 EDN10549.1 - 0.0098 16.0 4.9 0.016 15.4 4.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3792) DUF3533 PF12051.8 EDN10549.1 - 0.26 10.2 3.7 0.34 9.8 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) RNase_H PF00075.24 EDN10550.1 - 3.8e-09 36.9 0.0 9.2e-09 35.6 0.0 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN10550.1 - 0.099 12.5 0.0 0.4 10.5 0.1 2.0 2 1 0 2 2 2 0 Reverse transcriptase-like Trypan_PARP PF05887.11 EDN10553.1 - 0.84 9.6 6.8 0.45 10.5 1.4 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Peptidase_S8 PF00082.22 EDN10554.1 - 8.3e-36 123.8 0.5 1.2e-35 123.2 0.5 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EDN10554.1 - 1e-27 96.0 1.2 2e-27 95.0 1.2 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain PX PF00787.24 EDN10556.1 - 1.6e-18 66.7 0.3 3.8e-18 65.5 0.3 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EDN10556.1 - 2.2e-13 50.3 9.0 5.1e-07 29.5 0.8 2.1 2 0 0 2 2 2 2 Vps5 C terminal like Sec34 PF04136.15 EDN10556.1 - 0.0061 16.5 0.4 0.0061 16.5 0.4 1.6 2 0 0 2 2 2 1 Sec34-like family Occludin_ELL PF07303.13 EDN10556.1 - 0.055 14.2 0.2 2.2 9.1 0.0 2.7 2 0 0 2 2 2 0 Occludin homology domain BAR PF03114.18 EDN10556.1 - 0.091 12.4 4.4 0.39 10.3 0.0 2.4 3 0 0 3 3 3 0 BAR domain DUF1664 PF07889.12 EDN10556.1 - 1 9.4 5.3 6.2 6.9 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EDN10556.1 - 1.2 9.1 3.8 0.56 10.2 0.4 2.0 2 1 1 3 3 3 0 Laminin Domain II FlaC_arch PF05377.11 EDN10556.1 - 1.5 9.3 3.9 25 5.4 0.5 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.20 EDN10556.1 - 1.7 8.6 5.6 2.8 8.0 0.4 2.5 2 0 0 2 2 2 0 Prefoldin subunit UPF0242 PF06785.11 EDN10556.1 - 1.7 8.7 5.5 21 5.1 2.2 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Pyr_redox_2 PF07992.14 EDN10558.1 - 4e-39 134.6 0.0 5.1e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDN10558.1 - 8.3e-16 58.1 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN10558.1 - 1.9e-14 54.0 0.0 7.9e-14 52.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDN10558.1 - 0.0019 18.6 0.0 0.0048 17.3 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding K_oxygenase PF13434.6 EDN10558.1 - 0.22 10.6 0.0 0.59 9.2 0.0 1.8 1 1 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 EDN10559.1 - 3.9e-86 290.1 0.0 4.4e-75 253.7 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 EDN10559.1 - 8.6e-13 48.5 0.0 3e-12 46.7 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 EDN10559.1 - 1.4e-07 31.6 0.0 1.8e-06 28.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.19 EDN10559.1 - 0.00042 20.7 0.3 0.0072 16.7 0.3 2.4 1 1 0 1 1 1 1 HMG (high mobility group) box DAO PF01266.24 EDN10559.1 - 0.00057 19.6 0.1 0.0016 18.1 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDN10559.1 - 0.00071 18.9 0.0 0.058 12.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDN10559.1 - 0.011 15.7 0.2 0.29 11.1 0.0 2.9 3 1 0 3 3 3 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EDN10559.1 - 0.13 10.9 0.2 1.5 7.4 0.0 2.3 3 0 0 3 3 3 0 HI0933-like protein FAD_binding_2 PF00890.24 EDN10559.1 - 4.7 6.2 6.3 3.7 6.5 1.9 2.2 2 0 0 2 2 2 0 FAD binding domain SNARE_assoc PF09335.11 EDN10560.1 - 3.2e-12 47.0 4.5 3.2e-12 47.0 4.5 2.9 2 1 1 3 3 3 1 SNARE associated Golgi protein Ni_hydr_CYTB PF01292.20 EDN10560.1 - 0.0039 16.8 3.0 3 7.4 0.0 2.3 2 0 0 2 2 2 2 Prokaryotic cytochrome b561 DUF3552 PF12072.8 EDN10560.1 - 0.014 14.9 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Vma12 PF11712.8 EDN10560.1 - 0.12 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase 7TMR-DISM_7TM PF07695.11 EDN10560.1 - 7.1 6.5 13.6 90 2.9 13.6 2.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling zf_CCCH_4 PF18345.1 EDN10561.1 - 1.9e-08 34.1 9.6 4.6e-06 26.5 1.3 2.9 2 1 0 2 2 2 2 Zinc finger domain DUF1771 PF08590.10 EDN10561.1 - 3.3e-08 33.8 9.6 3.3e-08 33.8 9.6 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EDN10561.1 - 4e-08 33.5 0.1 1.1e-07 32.1 0.1 1.8 1 0 0 1 1 1 1 Smr domain zf-CCCH PF00642.24 EDN10561.1 - 4.7e-08 32.7 2.0 0.0042 17.0 0.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EDN10561.1 - 1.1e-06 28.8 3.9 0.0019 18.6 0.3 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EDN10561.1 - 1.6e-06 27.8 10.9 6.3e-05 22.7 0.7 3.2 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDN10561.1 - 0.00055 20.1 2.4 0.75 10.0 0.0 2.5 1 1 1 2 2 2 2 Zinc-finger containing family CUE PF02845.16 EDN10561.1 - 0.035 13.8 0.1 0.089 12.5 0.1 1.6 1 0 0 1 1 1 0 CUE domain Torus PF16131.5 EDN10561.1 - 0.06 14.0 2.2 2 9.1 0.4 2.6 1 1 1 2 2 2 0 Torus domain HBS1_N PF08938.10 EDN10561.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 HBS1 N-terminus DUF846 PF05832.12 EDN10562.1 - 1.4e-42 145.0 9.0 1.7e-42 144.8 9.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMEM220 PF15071.6 EDN10562.1 - 0.034 14.9 0.8 0.043 14.6 0.3 1.5 2 0 0 2 2 2 0 Transmembrane family 220, helix DUF2207 PF09972.9 EDN10562.1 - 8.7 5.0 6.7 1.6 7.4 3.4 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Acyl-CoA_dh_1 PF00441.24 EDN10563.1 - 0.00019 21.7 0.3 0.00022 21.4 0.3 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ECH_1 PF00378.20 EDN10564.1 - 1.1e-35 123.2 0.0 6.4e-26 91.2 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN10564.1 - 1.7e-18 67.3 0.1 7.1e-09 35.6 0.1 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase zf-CCHC PF00098.23 EDN10565.1 - 2e-25 87.7 38.5 7.1e-07 29.0 2.8 6.3 6 0 0 6 6 6 5 Zinc knuckle zf-CCHC_4 PF14392.6 EDN10565.1 - 9.9e-07 28.4 24.0 0.095 12.5 0.8 5.1 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_6 PF15288.6 EDN10565.1 - 7.2e-05 22.5 33.7 0.034 14.0 1.5 5.2 4 1 1 5 5 5 4 Zinc knuckle Elf1 PF05129.13 EDN10565.1 - 0.0016 18.5 4.1 0.0016 18.5 4.1 3.3 1 1 2 3 3 3 1 Transcription elongation factor Elf1 like Sgf11 PF08209.11 EDN10565.1 - 6.9 6.3 21.4 25 4.6 0.2 5.4 5 0 0 5 5 5 0 Sgf11 (transcriptional regulation protein) zinc_ribbon_4 PF13717.6 EDN10565.1 - 7.8 6.5 22.2 2.5 8.1 3.8 4.5 4 0 0 4 4 4 0 zinc-ribbon domain MFS_1 PF07690.16 EDN10566.1 - 4.6e-26 91.6 26.5 4.6e-26 91.6 26.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDN10566.1 - 0.0027 17.4 1.8 0.0049 16.6 1.8 1.4 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Imm57 PF15596.6 EDN10566.1 - 0.15 12.4 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 57 PRIMA1 PF16101.5 EDN10566.1 - 0.44 10.6 2.6 23 5.1 0.0 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF3341 PF11821.8 EDN10566.1 - 5.2 6.7 5.1 8.8 5.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3341) Gln-synt_N PF03951.19 EDN10567.1 - 3.9e-14 52.2 0.0 5.7e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Med1 PF10744.9 EDN10568.1 - 3.1e-58 197.8 0.0 4.3e-58 197.3 0.0 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Med1 PF10744.9 EDN10569.1 - 4.2e-122 408.2 0.0 5.2e-122 407.9 0.0 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 WD40 PF00400.32 EDN10570.1 - 2e-44 148.7 25.5 1.3e-09 38.5 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10570.1 - 2.2e-09 37.5 0.5 0.075 13.3 0.0 4.5 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN10570.1 - 2.7e-05 23.0 7.0 0.077 11.6 0.2 4.7 1 1 2 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDN10570.1 - 0.0058 15.6 0.0 7.7 5.4 0.0 3.9 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EDN10570.1 - 0.0071 14.9 0.0 0.61 8.6 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 EDN10570.1 - 0.015 14.7 0.0 0.87 8.8 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain PD40 PF07676.12 EDN10570.1 - 0.019 14.9 0.6 20 5.3 0.0 4.3 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Sdh5 PF03937.16 EDN10571.1 - 4.8e-26 90.5 1.0 1.4e-25 89.1 0.6 1.9 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase EMP24_GP25L PF01105.24 EDN10572.1 - 3.5e-41 141.2 0.0 4e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Nop14 PF04147.12 EDN10574.1 - 0.23 9.6 10.4 0.28 9.4 10.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 EDN10574.1 - 1.2 8.2 13.7 1.7 7.7 13.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 EDN10574.1 - 3.7 6.8 9.0 5.1 6.3 9.0 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EDN10574.1 - 3.9 6.8 11.3 5.2 6.4 11.3 1.1 1 0 0 1 1 1 0 SDA1 NDUFA12 PF05071.16 EDN10577.1 - 6.7e-12 46.1 3.3 1.2e-11 45.3 3.3 1.7 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 CH PF00307.31 EDN10578.1 - 6.1e-13 48.9 0.0 1.2e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain adh_short_C2 PF13561.6 EDN10580.1 - 2.4e-52 177.8 0.2 3.4e-52 177.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDN10580.1 - 2.7e-43 147.7 0.2 3.8e-43 147.2 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDN10580.1 - 1.3e-11 44.8 0.5 2.1e-11 44.0 0.5 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EDN10580.1 - 0.037 13.0 0.1 0.06 12.4 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PBP1_TM PF14812.6 EDN10581.1 - 3.5 8.0 7.2 2.6 8.5 4.7 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HAD_2 PF13419.6 EDN10582.1 - 5.2e-16 59.2 0.0 4.8e-15 56.1 0.0 2.2 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN10582.1 - 9.3e-15 55.5 0.0 4.4e-11 43.5 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDN10582.1 - 1.5e-08 34.6 0.1 3.4e-08 33.4 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like PGP_phosphatase PF09419.10 EDN10582.1 - 0.003 17.2 0.0 0.19 11.4 0.0 2.3 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase S6PP PF05116.13 EDN10582.1 - 0.013 15.1 0.0 0.038 13.5 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 EDN10582.1 - 0.018 15.4 0.1 0.46 10.9 0.1 2.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDN10582.1 - 0.057 13.1 0.0 4.3 7.0 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase ORMDL PF04061.14 EDN10584.1 - 7.8e-55 184.4 4.3 9.6e-55 184.1 4.3 1.1 1 0 0 1 1 1 1 ORMDL family DUF2236 PF09995.9 EDN10587.1 - 9.8e-35 120.8 0.4 9.8e-35 120.8 0.4 1.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2236) SecG PF03840.14 EDN10587.1 - 0.082 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Preprotein translocase SecG subunit Helicase_C PF00271.31 EDN10588.1 - 3.6e-23 82.0 0.0 2.1e-22 79.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDN10588.1 - 9.6e-20 70.6 0.1 1.7e-19 69.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) DEAD PF00270.29 EDN10588.1 - 3.6e-10 39.9 0.0 9.8e-10 38.5 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase TRP PF06011.12 EDN10589.1 - 4.1e-112 375.0 23.1 4.8e-112 374.8 23.1 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel Neurokinin_B PF03823.14 EDN10589.1 - 0.028 14.5 0.0 0.028 14.5 0.0 2.5 3 0 0 3 3 3 0 Neurokinin B DUF1419 PF07215.11 EDN10589.1 - 0.31 11.2 0.9 0.63 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1419) SIT PF15330.6 EDN10589.1 - 0.89 10.0 3.5 3.7 8.0 0.0 3.2 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4834 PF16118.5 EDN10589.1 - 8.1 7.5 6.4 17 6.5 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TRP PF06011.12 EDN10590.1 - 2.3e-17 62.9 0.1 2.9e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF4389 PF14333.6 EDN10590.1 - 0.04 13.8 0.1 0.064 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) DUF3602 PF12223.8 EDN10591.1 - 4e-20 72.2 3.8 8.5e-19 67.9 0.7 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) Actin PF00022.19 EDN10592.1 - 1.6e-125 418.9 0.0 6.8e-125 416.9 0.0 1.7 1 1 0 1 1 1 1 Actin DUF4692 PF15763.5 EDN10592.1 - 0.017 15.6 0.0 0.026 15.0 0.0 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Glyco_tran_28_C PF04101.16 EDN10593.1 - 5.4e-20 72.0 0.1 1.7e-19 70.4 0.1 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain MRP-S28 PF10213.9 EDN10594.1 - 1.7e-09 38.1 0.0 3.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein SNF2_N PF00176.23 EDN10597.1 - 6.5e-53 179.7 0.1 1.2e-52 178.8 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 EDN10597.1 - 5.2e-28 96.7 0.4 1.3e-27 95.4 0.4 1.7 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EDN10597.1 - 2.6e-18 66.4 0.0 6.3e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EDN10597.1 - 2e-07 30.5 2.9 1.2e-06 28.0 2.9 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EDN10597.1 - 0.00056 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Chromo PF00385.24 EDN10597.1 - 0.00063 19.6 9.5 0.06 13.3 0.2 2.9 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.29 EDN10597.1 - 0.0042 16.9 0.0 0.0083 15.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SpoU_methylase PF00588.19 EDN10598.1 - 2.7e-06 27.6 0.1 5.9e-06 26.5 0.1 1.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family SNF2_N PF00176.23 EDN10599.1 - 1.1e-74 251.3 0.1 2.3e-74 250.2 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain HAND PF09110.11 EDN10599.1 - 1.8e-38 131.7 2.5 1.8e-38 131.7 2.5 3.4 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 EDN10599.1 - 2.5e-18 66.4 1.0 1e-17 64.5 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SLIDE PF09111.10 EDN10599.1 - 7e-11 42.2 1.9 3.9e-10 39.8 1.9 2.3 1 0 0 1 1 1 1 SLIDE ResIII PF04851.15 EDN10599.1 - 3.6e-08 33.6 0.5 1.5e-07 31.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDN10599.1 - 0.00015 21.1 0.0 0.00049 19.4 0.0 1.9 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EDN10599.1 - 0.00019 21.3 0.0 0.00051 19.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Tn7_Tnp_TnsA_C PF08721.11 EDN10599.1 - 0.0045 17.6 0.6 0.18 12.5 0.0 3.5 3 0 0 3 3 3 1 TnsA endonuclease C terminal DUF1086 PF06461.11 EDN10599.1 - 0.0055 16.6 0.1 0.016 15.1 0.1 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) AAA_14 PF13173.6 EDN10599.1 - 0.083 12.9 0.2 0.44 10.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF4588 PF15251.6 EDN10600.1 - 0.00017 21.4 5.3 0.0014 18.5 5.3 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) Adap_comp_sub PF00928.21 EDN10601.1 - 2.1e-61 207.6 0.0 2.8e-61 207.2 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDN10601.1 - 1.9e-05 24.6 0.0 3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Aldedh PF00171.22 EDN10602.1 - 4.3e-72 243.1 0.0 8e-72 242.2 0.0 1.4 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EDN10602.1 - 0.041 12.9 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Rif1_N PF12231.8 EDN10603.1 - 2.1e-62 211.3 9.9 1.4e-58 198.7 0.6 2.8 2 1 1 3 3 3 2 Rap1-interacting factor 1 N terminal Polysacc_synt_4 PF04669.13 EDN10604.1 - 1.3e-19 70.5 0.9 5.8e-18 65.1 0.9 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis DUF2491 PF10679.9 EDN10604.1 - 0.0036 16.5 1.2 0.0042 16.3 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2491) Sugar_tr PF00083.24 EDN10605.1 - 1.8e-103 346.8 12.2 7.6e-66 222.8 2.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDN10605.1 - 1.3e-20 73.6 33.5 1e-11 44.4 9.7 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDN10605.1 - 0.00021 20.0 14.2 0.00077 18.1 1.8 2.4 2 1 0 2 2 2 2 MFS/sugar transport protein DUF2530 PF10745.9 EDN10605.1 - 0.51 10.6 7.1 0.24 11.7 1.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2530) DUF21 PF01595.20 EDN10605.1 - 4.7 6.9 6.0 14 5.3 0.6 2.3 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain ABC_tran PF00005.27 EDN10606.1 - 9e-29 100.7 0.0 1.4e-28 100.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDN10606.1 - 1.8e-10 40.9 2.2 2.5e-05 24.1 0.1 2.9 1 1 1 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EDN10606.1 - 1.7e-05 24.4 0.0 0.021 14.3 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDN10606.1 - 0.00097 19.6 0.0 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 EDN10606.1 - 0.0013 17.7 0.0 0.061 12.1 0.0 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_29 PF13555.6 EDN10606.1 - 0.0015 18.3 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EDN10606.1 - 0.0097 16.2 0.0 0.088 13.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EDN10606.1 - 0.015 15.2 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 EDN10606.1 - 0.015 15.2 0.1 3.8 7.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EDN10606.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDN10606.1 - 0.061 12.6 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 EDN10606.1 - 0.066 13.4 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.6 EDN10606.1 - 0.08 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) MMR_HSR1 PF01926.23 EDN10606.1 - 0.093 12.8 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 EDN10607.1 - 1.7e-30 106.3 0.0 2.8e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDN10607.1 - 5.3e-19 68.9 1.7 7.9e-19 68.3 1.7 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDN10607.1 - 2.1e-06 27.4 0.1 0.0029 17.1 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EDN10607.1 - 4e-06 27.1 0.1 0.001 19.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDN10607.1 - 0.0017 18.8 0.4 0.0089 16.4 0.3 2.3 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDN10607.1 - 0.0022 18.0 0.0 0.0045 16.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EDN10607.1 - 0.004 16.8 0.0 0.079 12.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDN10607.1 - 0.0043 16.8 0.2 0.0085 15.8 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EDN10607.1 - 0.0071 15.2 0.1 0.067 12.0 0.1 2.3 2 1 0 2 2 2 1 Predicted ATPase of the ABC class IstB_IS21 PF01695.17 EDN10607.1 - 0.015 15.0 0.0 0.046 13.5 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 EDN10607.1 - 0.017 14.8 0.1 0.12 12.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDN10607.1 - 0.021 15.3 0.1 0.036 14.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDN10607.1 - 0.022 15.3 0.1 0.057 14.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDN10607.1 - 0.023 14.9 0.6 0.057 13.7 0.4 1.7 2 0 0 2 2 1 0 AAA domain AAA_21 PF13304.6 EDN10607.1 - 0.024 14.5 0.1 1 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Mg_chelatase PF01078.21 EDN10607.1 - 0.024 14.0 0.1 0.042 13.2 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 EDN10607.1 - 0.028 14.9 0.3 0.29 11.6 0.1 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EDN10607.1 - 0.028 13.8 0.1 4 6.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.14 EDN10607.1 - 0.028 14.4 0.1 0.12 12.3 0.0 2.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EDN10607.1 - 0.042 14.1 0.0 0.13 12.5 0.0 1.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 EDN10607.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EDN10607.1 - 0.071 12.8 0.2 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EDN10607.1 - 0.087 12.0 0.1 0.19 10.9 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.15 EDN10607.1 - 0.094 12.6 0.8 0.17 11.8 0.2 1.7 2 0 0 2 2 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 EDN10607.1 - 0.1 13.0 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 EDN10607.1 - 0.14 12.3 0.2 0.27 11.4 0.2 1.6 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDN10607.1 - 0.14 12.2 0.2 0.28 11.3 0.2 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2244 PF10003.9 EDN10607.1 - 1.3 8.7 3.9 0.76 9.4 1.9 1.7 2 0 0 2 2 1 0 Integral membrane protein (DUF2244) CR6_interact PF10147.9 EDN10608.1 - 0.015 15.1 6.3 0.023 14.4 6.3 1.3 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Neur_chan_memb PF02932.16 EDN10608.1 - 0.082 13.0 1.3 0.24 11.4 1.3 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF3_subunit PF08597.10 EDN10608.1 - 0.23 11.3 5.6 0.35 10.8 5.6 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit FA_hydroxylase PF04116.13 EDN10610.1 - 6.6e-23 81.5 13.9 6.6e-23 81.5 13.9 1.9 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Phenol_monoox PF04663.12 EDN10610.1 - 1.1 9.4 5.6 5.8 7.1 0.4 3.0 3 1 0 3 3 3 0 Phenol hydroxylase conserved region Cep57_MT_bd PF06657.13 EDN10611.1 - 7.7e-24 83.9 1.0 7.7e-24 83.9 1.0 3.3 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 Cep57_CLD_2 PF14197.6 EDN10611.1 - 3.1e-21 75.2 5.4 3.1e-21 75.2 5.4 3.7 4 0 0 4 4 4 1 Centrosome localisation domain of PPC89 HALZ PF02183.18 EDN10611.1 - 0.12 12.6 7.2 0.025 14.8 2.0 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 EDN10611.1 - 0.55 10.9 22.6 0.47 11.1 5.5 4.4 3 2 2 5 5 5 0 Initiation control protein YabA MAT1 PF06391.13 EDN10612.1 - 3.4e-41 141.3 13.7 4.5e-41 140.9 13.7 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EDN10612.1 - 1.6e-32 111.1 9.0 2.4e-32 110.6 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDN10612.1 - 0.00021 21.1 4.5 0.00082 19.2 4.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN10612.1 - 0.0012 18.6 4.1 0.0027 17.5 4.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDN10612.1 - 0.0027 18.0 6.1 0.005 17.1 6.1 1.5 1 0 0 1 1 1 1 Ring finger domain DUF5338 PF17273.2 EDN10612.1 - 0.0074 16.3 0.9 4.8 7.3 0.2 3.5 3 0 0 3 3 3 1 Family of unknown function (DUF5338) Zn_ribbon_17 PF17120.5 EDN10612.1 - 0.01 15.4 1.4 0.023 14.3 1.4 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EDN10612.1 - 0.024 14.6 7.3 0.53 10.3 8.1 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 EDN10612.1 - 0.14 11.9 7.1 0.58 10.0 2.2 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EDN10612.1 - 0.35 10.9 6.8 0.73 9.9 6.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 EDN10612.1 - 2 8.3 8.4 84 3.1 9.3 2.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF3797 PF12677.7 EDN10612.1 - 2.6 8.0 8.0 0.11 12.3 2.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) Prefoldin_3 PF13758.6 EDN10613.1 - 1.2e-38 131.1 2.1 2.7e-38 130.0 2.1 1.6 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.7 EDN10613.1 - 3.4e-27 95.1 6.6 3.8e-25 88.5 0.1 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF3835) Pkinase PF00069.25 EDN10614.1 - 6e-41 140.6 0.0 1.6e-40 139.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10614.1 - 1.4e-25 90.0 0.0 2.2e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN10614.1 - 0.0042 17.0 0.5 0.075 12.9 0.0 2.9 3 1 1 4 4 4 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDN10614.1 - 0.0044 15.9 0.1 0.039 12.7 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDN10614.1 - 0.016 14.6 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CSN7a_helixI PF18392.1 EDN10614.1 - 0.13 12.2 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain NGP1NT PF08153.12 EDN10615.1 - 1.3e-49 167.6 0.2 2.1e-49 167.0 0.2 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EDN10615.1 - 5.4e-17 61.9 0.0 2.3e-13 50.2 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN10615.1 - 1.4e-05 24.6 0.0 0.00014 21.4 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 EDN10615.1 - 0.00086 18.8 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDN10615.1 - 0.0023 17.9 0.0 0.0069 16.3 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EDN10615.1 - 0.0034 17.4 1.1 0.89 9.6 0.0 3.6 3 1 1 4 4 4 1 Dynamin family GTP_EFTU PF00009.27 EDN10615.1 - 0.014 14.9 0.0 1.3 8.5 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Roc PF08477.13 EDN10615.1 - 0.12 12.6 0.1 28 5.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2380 PF09533.10 EDN10616.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) MRP-S26 PF14943.6 EDN10616.1 - 0.22 11.4 8.1 0.99 9.3 0.3 2.2 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 Lactamase_B PF00753.27 EDN10617.1 - 0.021 14.8 0.0 0.038 14.0 0.0 1.4 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily But2 PF09792.9 EDN10618.1 - 1.6e-46 158.2 0.0 2.1e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain PAP2 PF01569.21 EDN10619.1 - 0.00039 20.2 0.1 0.00039 20.2 0.1 1.8 2 0 0 2 2 2 1 PAP2 superfamily DUF872 PF05915.12 EDN10620.1 - 0.036 14.2 0.5 0.14 12.4 0.5 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) SelK_SelG PF10961.8 EDN10620.1 - 0.089 13.4 1.5 0.31 11.7 0.1 2.2 2 0 0 2 2 2 0 Selenoprotein SelK_SelG MARVEL PF01284.23 EDN10620.1 - 0.1 12.6 9.6 0.17 11.9 9.6 1.3 1 0 0 1 1 1 0 Membrane-associating domain DUF4173 PF13777.6 EDN10620.1 - 0.15 11.4 1.8 0.24 10.8 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) AA_permease_2 PF13520.6 EDN10621.1 - 3.1e-82 276.7 23.8 3.1e-82 276.7 23.8 1.3 1 1 0 1 1 1 1 Amino acid permease PsbN PF02468.15 EDN10621.1 - 0.097 12.5 1.5 0.77 9.6 1.5 2.6 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) DUF3112 PF11309.8 EDN10621.1 - 1.3 8.4 5.9 0.18 11.2 0.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3112) ERAP1_C PF11838.8 EDN10622.1 - 1.8e-87 293.8 2.5 8.3e-86 288.4 0.2 2.5 2 1 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EDN10622.1 - 2e-83 279.3 1.8 2.9e-83 278.7 1.8 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDN10622.1 - 1.2e-51 175.5 0.3 2.3e-51 174.6 0.3 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Helicase_C PF00271.31 EDN10623.1 - 0.0034 17.7 0.4 0.0065 16.8 0.2 1.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN10624.1 - 3.7e-47 160.3 0.0 5.2e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDN10624.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2986 PF11661.8 EDN10624.1 - 1.2 9.7 5.5 0.54 10.8 0.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2986) TPR_14 PF13428.6 EDN10625.1 - 0.00087 19.9 4.9 0.081 13.8 0.0 5.2 5 2 2 7 7 7 1 Tetratricopeptide repeat Suf PF05843.14 EDN10625.1 - 0.0032 17.5 0.2 0.0032 17.5 0.2 3.3 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) HAT PF02184.16 EDN10625.1 - 3.4 7.7 20.7 13 5.9 0.0 6.3 6 0 0 6 6 6 0 HAT (Half-A-TPR) repeat Mitoc_mL59 PF18126.1 EDN10626.1 - 3.4e-49 166.4 2.5 5.8e-49 165.7 2.5 1.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 MOSC_N PF03476.16 EDN10627.1 - 8.1e-21 74.1 0.0 1.5e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 EDN10627.1 - 4.9e-13 48.8 0.0 7.6e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF3543 PF12063.8 EDN10628.1 - 1.8e-97 325.6 0.0 2.6e-97 325.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EDN10628.1 - 2e-36 125.7 0.0 5.4e-36 124.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10628.1 - 6.7e-23 81.3 0.0 2.8e-22 79.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase DUF2062 PF09835.9 EDN10629.1 - 0.021 14.7 0.6 1.5 8.7 0.9 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2062) HTH_psq PF05225.16 EDN10630.1 - 0.044 13.5 0.6 0.088 12.6 0.6 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain LCIB_C_CA PF18599.1 EDN10631.1 - 0.18 11.1 8.3 0.21 10.8 8.3 1.0 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases DBINO PF13892.6 EDN10631.1 - 0.76 10.1 24.0 0.85 10.0 24.0 1.0 1 0 0 1 1 1 0 DNA-binding domain Lge1 PF11488.8 EDN10631.1 - 3 8.1 13.1 0.97 9.7 7.8 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 Borrelia_P83 PF05262.11 EDN10631.1 - 3.8 5.9 22.7 4.2 5.7 22.7 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein nsp8 PF08717.10 EDN10631.1 - 3.8 7.3 13.0 4.4 7.1 13.0 1.1 1 0 0 1 1 1 0 nsp8 replicase Halogen_Hydrol PF10112.9 EDN10631.1 - 4.1 7.4 10.6 5.1 7.1 10.6 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DivIVA PF05103.13 EDN10631.1 - 4.3 7.4 21.3 5.6 7.1 21.3 1.2 1 0 0 1 1 1 0 DivIVA protein TERB2 PF15101.6 EDN10631.1 - 6.4 6.8 10.0 7.9 6.5 10.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Diphthami_syn_2 PF01902.17 EDN10632.1 - 6.9e-17 61.7 0.0 1.1e-05 25.1 0.0 4.2 4 0 0 4 4 4 4 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EDN10632.1 - 2.2e-08 34.1 0.0 3.5e-06 27.0 0.0 2.8 2 0 0 2 2 2 1 Endoribonuclease L-PSP FAD-SLDH PF12318.8 EDN10632.1 - 0.07 13.2 4.6 0.17 11.9 4.6 1.6 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF3446 PF11928.8 EDN10632.1 - 1.3 9.4 6.5 3.4 8.0 6.5 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain Pkinase PF00069.25 EDN10633.1 - 9.5e-14 51.4 0.0 3.7e-13 49.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10633.1 - 2.3e-06 27.1 0.0 4e-06 26.3 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EDN10633.1 - 0.19 11.1 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAT1 PF09770.9 EDN10634.1 - 3.3 5.9 13.7 3.9 5.6 13.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SPX PF03105.19 EDN10634.1 - 5.4 6.8 10.8 6.7 6.5 10.8 1.1 1 0 0 1 1 1 0 SPX domain PITH PF06201.13 EDN10635.1 - 2.3e-34 118.8 0.0 3.4e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EDN10635.1 - 1.1e-28 99.3 0.0 3.7e-28 97.5 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 EDN10635.1 - 9.3e-07 28.5 0.0 2.1e-06 27.3 0.0 1.5 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDN10635.1 - 7.5e-06 26.4 0.0 5.1e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDN10635.1 - 1.3e-05 25.5 0.0 0.00077 19.8 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 EDN10635.1 - 0.00012 21.8 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EDN10635.1 - 0.00036 20.3 0.0 0.42 10.3 0.0 2.2 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.21 EDN10635.1 - 0.00042 20.2 0.0 0.027 14.4 0.0 2.3 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EDN10635.1 - 0.00071 19.7 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 EDN10635.1 - 0.018 15.0 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 EDN10635.1 - 0.044 13.5 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_6 PF13848.6 EDN10635.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain zf-CSL PF05207.13 EDN10636.1 - 4.2e-18 64.8 0.1 1e-17 63.5 0.1 1.7 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EDN10636.1 - 0.00095 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain peroxidase PF00141.23 EDN10637.1 - 4.8e-25 88.6 0.0 7e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Peroxidase EMC3_TMCO1 PF01956.16 EDN10638.1 - 0.051 13.3 2.2 0.059 13.1 2.2 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Dzip-like_N PF13815.6 EDN10638.1 - 0.087 12.8 6.9 0.22 11.5 6.9 1.6 1 1 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF4611 PF15387.6 EDN10638.1 - 0.78 10.0 5.0 1.2 9.4 4.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) Zn_clus PF00172.18 EDN10640.1 - 0.00011 22.2 6.6 0.00025 21.1 6.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lipoprotein_7 PF01540.16 EDN10640.1 - 0.028 13.7 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein FTR PF01913.18 EDN10640.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase WD40 PF00400.32 EDN10641.1 - 4.5e-13 49.5 12.2 0.002 18.9 0.2 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10641.1 - 0.00038 20.7 0.3 0.52 10.7 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN10641.1 - 0.0034 16.4 0.1 2.5 7.0 0.0 2.8 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein UAA PF08449.11 EDN10642.1 - 0.13 11.5 0.2 0.77 8.9 0.1 1.8 2 0 0 2 2 2 0 UAA transporter family Aconitase PF00330.20 EDN10643.1 - 1.8e-145 485.5 0.0 2.3e-145 485.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDN10643.1 - 1.4e-37 128.9 0.0 2.8e-37 128.0 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Glyco_transf_5 PF08323.11 EDN10644.1 - 1.7e-11 44.3 0.2 3.9e-11 43.1 0.2 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain Arylesterase PF01731.20 EDN10644.1 - 4.2e-08 33.3 0.2 1.1e-07 31.9 0.2 1.8 1 0 0 1 1 1 1 Arylesterase Alpha-amylase PF00128.24 EDN10644.1 - 2.4e-05 24.1 3.8 0.0017 18.0 0.0 3.3 2 1 1 3 3 3 2 Alpha amylase, catalytic domain SGL PF08450.12 EDN10644.1 - 0.00011 21.9 0.1 0.00023 20.8 0.1 1.5 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Glycos_transf_1 PF00534.20 EDN10644.1 - 0.00014 21.5 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Lactonase PF10282.9 EDN10644.1 - 0.054 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Glyco_transf_4 PF13439.6 EDN10644.1 - 0.076 13.0 0.2 0.24 11.4 0.2 1.8 1 0 0 1 1 1 0 Glycosyltransferase Family 4 MTHFR PF02219.17 EDN10646.1 - 8.2e-103 343.7 0.0 1.1e-101 339.9 0.0 2.1 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF2418 PF10332.9 EDN10647.1 - 1.5e-33 115.1 0.5 1.5e-33 115.1 0.5 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF2418) ATP-synt_F PF01990.17 EDN10648.1 - 1.3e-05 25.4 0.0 1.4e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit CryBP1 PF07029.11 EDN10649.1 - 0.029 14.5 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 CryBP1 protein NOGCT PF08155.11 EDN10650.1 - 0.00039 20.3 1.0 0.00039 20.3 1.0 1.9 2 0 0 2 2 2 1 NOGCT (NUC087) domain NOG1_N PF17835.1 EDN10651.1 - 1.3e-05 25.3 0.0 1.5e-05 25.0 0.0 1.0 1 0 0 1 1 1 1 NOG1 N-terminal helical domain Acetyltransf_1 PF00583.25 EDN10652.1 - 1.8e-11 44.3 0.0 2.4e-11 43.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDN10652.1 - 1.4e-09 38.0 0.0 2.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDN10652.1 - 4e-08 33.6 0.0 8.1e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN10652.1 - 0.003 17.5 0.0 0.0063 16.5 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EDN10652.1 - 0.054 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EDN10652.1 - 0.14 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Asp_protease PF09668.10 EDN10653.1 - 2.3e-59 198.6 0.4 3.5e-59 198.0 0.4 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EDN10653.1 - 3.4e-22 78.8 0.0 8.6e-22 77.5 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDN10653.1 - 1.6e-10 41.5 0.2 5e-10 39.9 0.0 2.0 2 0 0 2 2 1 1 Aspartyl protease ubiquitin PF00240.23 EDN10653.1 - 7e-10 38.5 0.1 1.5e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EDN10653.1 - 2.3e-08 33.8 0.0 5e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain UN_NPL4 PF11543.8 EDN10653.1 - 0.00013 22.4 0.2 0.00034 21.0 0.0 1.8 2 0 0 2 2 1 1 Nuclear pore localisation protein NPL4 Rad60-SLD PF11976.8 EDN10653.1 - 0.00097 18.9 0.1 0.0022 17.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 EDN10653.1 - 0.0047 16.7 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain Ubiquitin_4 PF18036.1 EDN10653.1 - 0.02 14.9 0.7 5.1 7.2 0.0 3.2 2 1 1 3 3 3 0 Ubiquitin-like domain RVP PF00077.20 EDN10653.1 - 0.025 14.9 0.0 0.066 13.5 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease RVP_2 PF08284.11 EDN10653.1 - 0.028 14.2 0.3 0.093 12.5 0.2 1.9 2 1 0 2 2 2 0 Retroviral aspartyl protease Gemin7 PF11095.8 EDN10653.1 - 0.13 12.1 0.8 2.1 8.3 0.3 2.6 2 0 0 2 2 2 0 Gem-associated protein 7 (Gemin7) NAD_binding_7 PF13241.6 EDN10653.1 - 0.14 12.6 0.0 0.47 10.9 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Cu-oxidase_3 PF07732.15 EDN10655.1 - 1.5e-41 141.2 0.4 6e-40 136.0 0.2 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDN10655.1 - 9.7e-19 67.5 0.3 4e-11 42.8 0.0 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EDN10655.1 - 1e-15 58.2 0.0 4.6e-15 56.1 0.0 2.1 1 1 0 1 1 1 1 Multicopper oxidase MazE_antitoxin PF04014.18 EDN10655.1 - 0.16 11.9 0.1 0.53 10.3 0.1 1.8 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin Methyltransf_25 PF13649.6 EDN10656.1 - 2.8e-05 24.7 0.0 5.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN10656.1 - 7.8e-05 23.3 0.0 0.00015 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN10656.1 - 0.00017 21.5 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN10656.1 - 0.00021 22.0 0.0 0.00042 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Git3 PF11710.8 EDN10657.1 - 2.6e-24 86.1 12.7 4.7e-24 85.3 12.7 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EDN10657.1 - 3.7e-09 36.5 0.1 3.7e-09 36.5 0.1 3.0 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EDN10657.1 - 0.0034 16.6 9.3 0.0077 15.4 9.2 1.4 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor PV-1 PF06637.11 EDN10657.1 - 0.099 11.4 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF5058 PF16481.5 EDN10657.1 - 0.11 12.1 4.3 0.33 10.6 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5058) DUF1035 PF06281.12 EDN10657.1 - 0.54 10.3 4.7 1.6 8.8 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1035) Methyltransf_23 PF13489.6 EDN10658.1 - 4.6e-06 26.6 0.0 7.6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EDN10659.1 - 3.9e-45 154.4 0.0 1.1e-44 153.0 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EDN10659.1 - 1.6e-05 25.5 0.0 9.6e-05 23.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN10659.1 - 0.00043 20.9 0.0 0.017 15.8 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain DUF5323 PF17257.2 EDN10659.1 - 0.31 10.9 3.4 0.28 11.1 1.1 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5323) Methyltransf_32 PF13679.6 EDN10659.1 - 0.51 10.3 1.5 1.1 9.2 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain DUF908 PF06012.12 EDN10659.1 - 0.92 8.9 0.0 0.92 8.9 0.0 2.5 2 1 0 2 2 2 0 Domain of Unknown Function (DUF908) Proteasome PF00227.26 EDN10660.1 - 4.2e-56 189.4 0.2 5.3e-56 189.1 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDN10660.1 - 1.4e-12 47.0 0.0 3.6e-12 45.7 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 EDN10661.1 - 2.6e-64 217.8 0.0 4.1e-64 217.1 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDN10661.1 - 1.3e-60 205.5 1.5 2e-60 204.9 1.5 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Thiolase_N PF00108.23 EDN10662.1 - 8.7e-40 136.7 0.0 3.4e-33 115.1 0.1 2.0 1 1 1 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN10662.1 - 0.07 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Thiolase, C-terminal domain AMP-binding PF00501.28 EDN10663.1 - 6.9e-51 173.2 0.0 9e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN10663.1 - 0.017 16.1 0.0 0.049 14.6 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain KH_8 PF17903.1 EDN10664.1 - 4.8e-30 103.5 0.0 1.2e-29 102.2 0.0 1.7 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDN10664.1 - 0.081 12.8 1.3 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 KH domain Agglutinin PF07468.11 EDN10665.1 - 0.088 13.0 0.0 0.31 11.2 0.0 1.7 1 1 1 2 2 2 0 Agglutinin domain adh_short PF00106.25 EDN10666.1 - 4.8e-36 124.1 0.0 6.7e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN10666.1 - 2.4e-21 76.4 0.0 3.5e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN10666.1 - 0.00095 19.1 0.0 0.005 16.8 0.0 2.0 1 1 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EDN10666.1 - 0.15 11.4 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Erg28 PF03694.13 EDN10667.1 - 2e-35 121.5 1.2 2.3e-35 121.3 1.2 1.0 1 0 0 1 1 1 1 Erg28 like protein GalP_UDP_transf PF01087.22 EDN10668.1 - 1.4e-68 230.9 0.0 9.2e-68 228.3 0.0 2.1 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EDN10668.1 - 4.4e-45 153.4 0.1 1.3e-44 151.8 0.2 1.7 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 EDN10668.1 - 0.018 13.9 0.1 1.5 7.5 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4921) HIT PF01230.23 EDN10668.1 - 0.021 15.6 0.0 0.14 12.9 0.0 2.2 2 0 0 2 2 2 0 HIT domain DcpS_C PF11969.8 EDN10668.1 - 0.059 13.9 0.1 0.16 12.5 0.1 1.7 2 0 0 2 2 2 0 Scavenger mRNA decapping enzyme C-term binding NAD_binding_2 PF03446.15 EDN10669.1 - 7.2e-27 94.5 0.0 1.8e-26 93.2 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EDN10669.1 - 9.7e-09 35.4 0.0 1.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EDN10669.1 - 4.5e-08 33.6 0.0 1e-07 32.5 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EDN10669.1 - 0.028 14.7 0.0 0.081 13.2 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain BAR_2 PF10455.9 EDN10671.1 - 3.7e-60 203.5 0.0 5.2e-60 203.0 0.0 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDN10671.1 - 3.6e-20 72.6 1.7 1.9e-18 67.0 1.7 2.1 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EDN10671.1 - 0.0075 16.0 0.2 0.27 10.9 0.0 2.6 2 1 0 2 2 2 1 BAR domain of APPL family Arv1 PF04161.13 EDN10673.1 - 6.3e-12 46.1 6.8 7.2e-12 45.9 6.8 1.0 1 0 0 1 1 1 1 Arv1-like family NAT PF04768.13 EDN10674.1 - 3.4e-47 160.3 0.0 8.8e-47 158.9 0.0 1.6 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Nucleoporin_N PF08801.11 EDN10676.1 - 7.6e-93 311.6 0.9 2.7e-92 309.8 0.6 1.9 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDN10676.1 - 1.2e-44 153.1 1.5 2.6e-44 152.0 0.6 1.8 1 1 0 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal DUF3802 PF12290.8 EDN10676.1 - 0.037 14.5 0.4 48 4.5 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3802) YqeY PF09424.10 EDN10677.1 - 8.1e-20 71.4 1.0 9.9e-20 71.1 1.0 1.1 1 0 0 1 1 1 1 Yqey-like protein Apolipoprotein PF01442.18 EDN10677.1 - 0.02 14.8 1.4 0.042 13.7 1.5 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain CD34_antigen PF06365.12 EDN10677.1 - 0.054 13.1 0.2 0.076 12.6 0.2 1.3 1 1 0 1 1 1 0 CD34/Podocalyxin family Sulfatase_C PF14707.6 EDN10677.1 - 0.064 14.0 0.2 0.17 12.6 0.0 1.7 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase Rot1 PF10681.9 EDN10678.1 - 9e-91 303.0 0.4 1.1e-90 302.7 0.4 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal 5-FTHF_cyc-lig PF01812.20 EDN10679.1 - 2.9e-36 125.1 0.1 1.1e-35 123.2 0.1 1.9 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Xpo1 PF08389.12 EDN10680.1 - 1.4e-29 103.1 0.1 1.1e-28 100.2 0.0 2.6 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 EDN10680.1 - 3.2e-06 27.0 0.2 1.2e-05 25.2 0.0 2.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EDN10680.1 - 0.0039 17.6 0.0 0.037 14.4 0.0 2.7 2 0 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 EDN10680.1 - 0.0051 17.3 0.7 0.14 12.7 0.0 3.9 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 EDN10680.1 - 0.013 15.7 0.0 30 5.2 0.0 4.2 3 0 0 3 3 3 0 HEAT repeat Importin_rep_3 PF18806.1 EDN10680.1 - 0.023 14.7 0.0 0.34 11.0 0.0 2.6 2 0 0 2 2 2 0 Importin 13 repeat DUF3385 PF11865.8 EDN10680.1 - 0.085 12.8 1.5 21 5.0 0.1 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 EDN10680.1 - 0.14 10.7 0.2 4.5 5.7 0.0 2.2 2 0 0 2 2 2 0 Adaptin N terminal region GAT PF03127.14 EDN10680.1 - 0.77 10.1 2.4 8.1 6.8 0.0 3.1 3 0 0 3 3 3 0 GAT domain Fungal_trans PF04082.18 EDN10682.1 - 2.7e-14 52.8 0.6 2.1e-10 40.1 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EDN10682.1 - 0.0028 18.0 4.1 0.0037 17.6 1.0 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type EF-hand_7 PF13499.6 EDN10683.1 - 7.8e-13 48.7 0.2 2.8e-08 34.1 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDN10683.1 - 4.1e-10 38.8 0.2 0.0065 16.3 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EDN10683.1 - 5.7e-10 38.0 0.1 0.017 14.6 0.0 3.7 3 1 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EDN10683.1 - 6.6e-10 39.2 0.0 0.00023 21.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EDN10683.1 - 4e-07 29.8 0.1 0.00012 21.8 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain pair DUF2052 PF09747.9 EDN10684.1 - 0.0049 17.0 3.9 0.0049 17.0 3.9 1.4 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) DNA_pol_phi PF04931.13 EDN10684.1 - 0.018 13.2 7.0 0.025 12.7 7.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EDN10684.1 - 0.035 12.3 10.1 0.055 11.7 10.1 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EDN10684.1 - 0.06 11.6 6.9 0.087 11.1 6.9 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EDN10684.1 - 0.18 11.6 3.9 0.3 10.9 3.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3c_N PF05470.12 EDN10684.1 - 0.43 8.8 5.4 0.63 8.3 5.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Pex14_N PF04695.13 EDN10684.1 - 0.48 11.1 3.9 3.4 8.3 2.9 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SDA1 PF05285.12 EDN10684.1 - 3.3 7.0 14.1 0.31 10.4 9.6 1.5 2 0 0 2 2 2 0 SDA1 BSP_II PF05432.11 EDN10684.1 - 5.7 6.5 19.6 0.58 9.8 13.3 1.9 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Peptidase_M3 PF01432.20 EDN10685.1 - 8.4e-35 120.9 0.3 2e-34 119.7 0.2 1.6 2 0 0 2 2 2 1 Peptidase family M3 DRE2_N PF16803.5 EDN10685.1 - 0.068 13.4 0.1 0.4 10.9 0.1 2.2 2 1 0 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus Xan_ur_permease PF00860.20 EDN10686.1 - 1.8e-50 171.8 11.1 3.1e-49 167.7 11.1 2.0 1 1 0 1 1 1 1 Permease family p450 PF00067.22 EDN10687.1 - 1.3e-16 60.4 0.0 1.6e-16 60.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EDN10688.1 - 5.6e-35 121.0 0.1 7.1e-35 120.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 BOP1NT PF08145.12 EDN10688.1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 BOP1NT (NUC169) domain RNase_H PF00075.24 EDN10689.1 - 2e-07 31.3 0.1 3.3e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.27 EDN10690.1 - 7.9e-10 38.6 0.0 9.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EDN10691.1 - 1.8e-33 115.9 0.0 3.5e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN10691.1 - 6.9e-13 48.5 0.1 3.8e-08 33.3 0.0 2.9 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EDN10691.1 - 1.2e-05 25.6 0.0 3.2e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Retrotran_gag_2 PF14223.6 EDN10691.1 - 0.22 11.2 1.8 0.58 9.8 1.8 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type APH PF01636.23 EDN10692.1 - 0.0028 17.6 0.0 0.0057 16.6 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family DDE_1 PF03184.19 EDN10693.1 - 1.2e-33 116.2 0.0 2.1e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN10693.1 - 3.2e-05 23.7 0.0 0.00045 20.0 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN10693.1 - 0.0087 16.1 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-CCHC_6 PF15288.6 EDN10693.1 - 0.14 12.0 0.4 1.6 8.6 0.1 2.5 2 0 0 2 2 2 0 Zinc knuckle Rhodanese PF00581.20 EDN10695.1 - 0.18 12.3 0.0 0.5 10.9 0.0 1.7 2 0 0 2 2 2 0 Rhodanese-like domain Integrase_H2C2 PF17921.1 EDN10696.1 - 5.3e-06 26.4 1.1 0.0013 18.8 0.1 2.7 2 0 0 2 2 2 2 Integrase zinc binding domain AAA PF00004.29 EDN10697.1 - 6e-09 36.4 0.0 1.6e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EDN10698.1 - 0.18 11.9 0.2 6.9 6.8 0.0 2.3 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein RTC4 PF14474.6 EDN10699.1 - 1.8e-26 92.7 0.1 2e-26 92.5 0.1 1.0 1 0 0 1 1 1 1 RTC4-like domain DNA_mis_repair PF01119.19 EDN10700.1 - 0.11 12.2 0.0 5 6.8 0.0 2.0 2 0 0 2 2 2 0 DNA mismatch repair protein, C-terminal domain Rad51 PF08423.11 EDN10702.1 - 2e-09 37.1 0.0 4.4e-05 22.9 0.0 2.4 2 1 0 2 2 2 2 Rad51 DnaB_C PF03796.15 EDN10702.1 - 0.0012 18.3 0.0 0.5 9.7 0.0 2.3 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain AAA PF00004.29 EDN10702.1 - 0.015 15.7 0.1 0.093 13.2 0.1 2.3 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EDN10702.1 - 0.018 14.4 0.9 0.15 11.4 0.1 2.5 2 1 0 2 2 2 0 KaiC AAA_16 PF13191.6 EDN10702.1 - 0.067 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EDN10702.1 - 0.071 13.6 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EDN10702.1 - 0.075 13.3 0.0 0.18 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN10702.1 - 0.094 12.4 0.0 0.2 11.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain RecA PF00154.21 EDN10702.1 - 0.21 11.0 0.3 0.49 9.8 0.1 1.6 2 0 0 2 2 2 0 recA bacterial DNA recombination protein MOSC PF03473.17 EDN10703.1 - 2.2e-21 76.3 0.0 6.6e-21 74.7 0.0 1.8 1 1 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EDN10703.1 - 2.7e-07 30.5 0.0 4.8e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain BRO1 PF03097.18 EDN10707.1 - 1.2e-54 185.7 1.3 1.6e-35 122.6 0.0 2.8 2 1 1 3 3 3 2 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDN10707.1 - 2.1e-39 135.6 7.7 4.3e-39 134.6 7.7 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF3347 PF11827.8 EDN10707.1 - 0.2 11.9 0.1 0.2 11.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) DnaJ_C PF01556.18 EDN10708.1 - 9.6e-41 139.3 0.1 1.3e-40 138.9 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EDN10708.1 - 7.3e-10 39.1 20.9 1.7e-09 37.9 20.9 1.7 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDN10708.1 - 0.07 13.1 13.7 1.2 9.2 2.5 2.7 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDN10708.1 - 0.18 11.9 9.3 0.3 11.1 1.7 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EDN10708.1 - 8.1 6.5 7.6 30 4.7 7.8 1.8 1 1 1 2 2 2 0 zinc-ribbons Lon_C PF05362.13 EDN10709.1 - 1e-62 211.3 0.0 2.6e-62 210.0 0.0 1.7 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EDN10709.1 - 3.1e-34 118.7 0.2 3.1e-34 118.7 0.2 1.9 3 0 0 3 3 3 1 ATP-dependent protease La (LON) substrate-binding domain ChlI PF13541.6 EDN10709.1 - 3.9e-05 23.5 0.0 9.2e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase F-box-like_2 PF13013.6 EDN10709.1 - 0.0066 16.4 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like domain DUF4276 PF14103.6 EDN10709.1 - 0.013 15.7 1.0 0.03 14.5 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4276) DUF445 PF04286.12 EDN10709.1 - 5.3 6.8 15.8 4.7 6.9 6.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF445) Pkinase PF00069.25 EDN10710.1 - 2.3e-10 40.3 0.0 3.7e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10710.1 - 2.4e-07 30.3 0.0 5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDN10710.1 - 0.12 11.8 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mob1_phocein PF03637.17 EDN10711.1 - 5.9e-26 91.5 0.0 9.2e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Mob1/phocein family DUF4667 PF15700.5 EDN10711.1 - 0.043 13.9 3.6 0.17 12.0 3.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) CxC6 PF18721.1 EDN10711.1 - 0.62 10.4 4.9 1.2 9.4 4.9 1.4 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases cobW PF02492.19 EDN10712.1 - 5.7e-30 104.2 0.2 8.2e-30 103.7 0.2 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EDN10712.1 - 0.00017 21.5 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain HAUS6_N PF14661.6 EDN10713.1 - 3.1e-49 167.6 0.2 5.5e-49 166.8 0.2 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus HD_3 PF13023.6 EDN10714.1 - 7.4e-49 165.9 0.1 9.2e-49 165.5 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EDN10714.1 - 1.3e-15 57.6 0.1 1.7e-15 57.2 0.1 1.1 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HIT PF01230.23 EDN10715.1 - 2.3e-24 86.0 0.1 6.2e-24 84.6 0.0 1.7 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EDN10715.1 - 0.00057 20.4 0.0 0.00095 19.6 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GalP_UDP_tr_C PF02744.17 EDN10715.1 - 0.13 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Rad4 PF03835.15 EDN10716.1 - 1.4e-33 115.6 0.0 4e-33 114.2 0.0 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EDN10716.1 - 9.9e-28 96.4 0.1 2.2e-27 95.3 0.1 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 EDN10716.1 - 2.2e-16 60.5 0.1 2.2e-16 60.5 0.1 2.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 EDN10716.1 - 2.2e-15 56.2 0.0 4.6e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 EDN10716.1 - 0.0011 19.4 0.0 0.0037 17.7 0.0 2.0 1 0 0 1 1 1 1 Transglutaminase-like superfamily NOA36 PF06524.12 EDN10716.1 - 2.5 7.4 20.5 4.5 6.5 20.5 1.3 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EDN10716.1 - 3.8 7.2 20.4 15 5.3 20.4 2.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CoA_binding_2 PF13380.6 EDN10717.1 - 2.4e-28 99.0 0.0 3.8e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 CoA binding domain NDC10_II PF16787.5 EDN10718.1 - 5.8e-22 78.1 0.0 8.3e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Phage_int_SAM_1 PF02899.17 EDN10718.1 - 0.0073 16.6 0.0 1.6 9.1 0.0 2.4 1 1 0 2 2 2 2 Phage integrase, N-terminal SAM-like domain NDC10_II PF16787.5 EDN10719.1 - 2.4e-13 49.8 0.9 2.4e-13 49.8 0.9 1.5 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 PSII_Pbs27 PF13326.6 EDN10719.1 - 0.012 16.0 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 0 Photosystem II Pbs27 Suf PF05843.14 EDN10719.1 - 0.041 13.9 2.8 0.048 13.6 2.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3716 PF12511.8 EDN10720.1 - 3.9e-15 55.6 2.3 5.1e-15 55.3 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Fungal_trans PF04082.18 EDN10721.1 - 5.4e-17 61.7 1.1 9.6e-17 60.9 1.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN10721.1 - 2.9e-10 40.1 8.3 4.7e-10 39.4 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EDN10721.1 - 0.021 13.7 0.3 0.041 12.7 0.0 1.5 2 0 0 2 2 2 0 Fungal specific transcription factor domain Sugarporin_N PF11471.8 EDN10721.1 - 0.078 12.9 0.3 0.36 10.8 0.2 2.1 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension PKcGMP_CC PF16808.5 EDN10721.1 - 4.4 7.3 6.9 3.9 7.4 0.7 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC2_membrane PF01061.24 EDN10722.1 - 2.4e-49 167.6 26.4 2.8e-32 111.8 5.1 3.3 2 1 0 2 2 2 2 ABC-2 type transporter PDR_CDR PF06422.12 EDN10722.1 - 2.2e-22 78.8 0.0 2.2e-22 78.8 0.0 2.4 2 0 0 2 2 2 1 CDR ABC transporter ABC_tran PF00005.27 EDN10722.1 - 3.6e-22 79.3 0.0 4.1e-17 63.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 EDN10722.1 - 0.00017 21.5 0.1 0.00033 20.6 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EDN10722.1 - 0.0024 17.9 0.1 0.0063 16.6 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EDN10722.1 - 0.0028 18.1 0.1 0.01 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain ABC_trans_N PF14510.6 EDN10722.1 - 0.0032 18.0 0.5 0.012 16.2 0.0 2.3 3 0 0 3 3 1 1 ABC-transporter N-terminal AAA_33 PF13671.6 EDN10722.1 - 0.0062 16.7 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EDN10722.1 - 0.011 15.6 0.7 0.44 10.3 0.2 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDN10722.1 - 0.015 15.0 0.3 0.044 13.5 0.3 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EDN10722.1 - 0.015 15.8 0.1 0.38 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EDN10722.1 - 0.023 15.0 0.0 0.12 12.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDN10722.1 - 0.059 12.9 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDN10722.1 - 0.15 12.5 1.2 0.97 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDN10722.1 - 0.2 11.3 1.3 0.36 10.4 1.3 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 EDN10722.1 - 0.27 10.5 1.8 1.2 8.3 0.2 2.2 2 0 0 2 2 2 0 Zeta toxin Fungal_trans_2 PF11951.8 EDN10723.1 - 7.6e-09 34.9 0.6 3.6e-06 26.0 0.1 2.3 1 1 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN10723.1 - 2.3e-06 27.6 7.4 2.3e-06 27.6 7.4 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VWC PF00093.18 EDN10723.1 - 6 7.3 11.5 5.1 7.5 0.2 2.7 3 0 0 3 3 3 0 von Willebrand factor type C domain LPMO_10 PF03067.15 EDN10724.1 - 8.2e-08 33.1 0.0 1.1e-07 32.7 0.0 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading MFS_1 PF07690.16 EDN10725.1 - 4.1e-33 114.8 16.2 7.4e-33 113.9 14.0 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4131 PF13567.6 EDN10725.1 - 0.36 10.4 8.0 0.4 10.3 0.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) LapA_dom PF06305.11 EDN10725.1 - 3.3 7.6 8.5 1.9 8.4 0.3 3.9 4 1 0 4 4 4 0 Lipopolysaccharide assembly protein A domain DUF2070 PF09843.9 EDN10725.1 - 5 5.3 6.5 0.28 9.4 0.6 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) AMP-binding PF00501.28 EDN10726.1 - 1.4e-71 241.3 0.1 1.7e-71 241.0 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN10726.1 - 3.6e-10 40.7 0.6 1e-09 39.2 0.6 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain CarboxypepD_reg PF13620.6 EDN10726.1 - 0.017 15.4 0.6 0.1 12.9 0.1 2.6 3 0 0 3 3 3 0 Carboxypeptidase regulatory-like domain bMG3 PF11974.8 EDN10726.1 - 0.17 11.9 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain PRIMA1 PF16101.5 EDN10727.1 - 0.53 10.3 6.8 1.2 9.2 6.8 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Sugar_tr PF00083.24 EDN10728.1 - 1.4e-13 50.5 4.0 1.8e-13 50.2 4.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN10728.1 - 1.2e-06 27.7 0.2 1.5e-06 27.4 0.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF998 PF06197.13 EDN10728.1 - 0.014 15.0 1.0 0.024 14.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF998) ABC_tran PF00005.27 EDN10729.1 - 3.6e-28 98.8 0.0 3.5e-26 92.4 0.0 2.5 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDN10729.1 - 9.7e-16 58.2 7.4 7.7e-13 48.7 0.0 3.2 2 1 1 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EDN10729.1 - 1.5e-08 34.4 0.0 3.9e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EDN10729.1 - 0.00014 22.1 0.0 0.0019 18.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDN10729.1 - 0.0029 17.3 0.1 0.0063 16.2 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDN10729.1 - 0.0033 17.4 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 EDN10729.1 - 0.0039 17.7 1.3 0.0083 16.6 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDN10729.1 - 0.013 15.9 0.0 0.043 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 EDN10729.1 - 0.02 14.6 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 EDN10729.1 - 0.025 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 EDN10729.1 - 0.051 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDN10729.1 - 0.057 13.9 0.2 11 6.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EDN10729.1 - 0.063 13.1 0.0 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ChiC PF06483.11 EDN10729.1 - 0.16 11.9 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 Chitinase C Cu_amine_oxid PF01179.20 EDN10730.1 - 2.2e-125 418.8 3.2 1.4e-93 314.1 0.7 2.1 1 1 1 2 2 2 2 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EDN10730.1 - 0.0022 18.2 0.1 0.0042 17.3 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain SOG2 PF10428.9 EDN10731.1 - 0.15 11.3 20.7 0.18 11.0 20.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein UQ_con PF00179.26 EDN10732.1 - 3.3e-40 137.0 0.0 3.7e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDN10732.1 - 2.1e-05 24.2 0.0 2.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 EDN10732.1 - 0.046 13.4 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 HhH-GPD PF00730.25 EDN10733.1 - 1.7e-19 70.2 0.0 1.8e-17 63.8 0.0 2.8 3 0 0 3 3 3 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDN10733.1 - 6e-07 29.0 0.0 5e-06 26.1 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif NifQ PF04891.12 EDN10733.1 - 2.1 8.7 7.0 0.43 10.9 1.5 2.5 3 0 0 3 3 3 0 NifQ AAA_11 PF13086.6 EDN10734.1 - 5e-62 210.0 0.4 1.7e-61 208.3 0.2 2.0 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EDN10734.1 - 1.5e-56 191.1 0.0 2.3e-56 190.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN10734.1 - 1.4e-11 44.5 0.0 1.6e-10 41.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDN10734.1 - 3.5e-09 37.1 0.0 8.1e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDN10734.1 - 1.9e-07 31.1 0.0 0.14 11.9 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EDN10734.1 - 6.9e-06 25.5 0.1 0.0001 21.7 0.1 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EDN10734.1 - 8.4e-06 25.9 0.0 4.2e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDN10734.1 - 5.4e-05 23.5 0.1 0.0027 18.0 0.1 2.6 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EDN10734.1 - 0.00019 21.0 0.0 0.0056 16.1 0.0 2.6 2 1 0 2 2 2 1 PhoH-like protein UvrD-helicase PF00580.21 EDN10734.1 - 0.00022 20.9 0.0 0.0027 17.3 0.0 2.0 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EDN10734.1 - 0.001 19.5 0.1 0.0022 18.4 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain Helicase_RecD PF05127.14 EDN10734.1 - 0.0049 16.8 0.0 0.35 10.7 0.0 2.5 2 0 0 2 2 2 1 Helicase UvrD_C PF13361.6 EDN10734.1 - 0.0054 16.2 0.0 4.1 6.7 0.0 2.7 2 1 0 3 3 3 2 UvrD-like helicase C-terminal domain T2SSE PF00437.20 EDN10734.1 - 0.0073 15.4 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_25 PF13481.6 EDN10734.1 - 0.0078 15.8 0.0 0.036 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EDN10734.1 - 0.0085 16.1 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Flavi_DEAD PF07652.14 EDN10734.1 - 0.011 15.7 0.0 0.079 12.9 0.0 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain UvrD_C_2 PF13538.6 EDN10734.1 - 0.011 15.5 0.0 0.2 11.5 0.0 2.8 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain AAA PF00004.29 EDN10734.1 - 0.019 15.4 0.0 0.078 13.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDN10734.1 - 0.047 13.4 0.0 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDN10734.1 - 0.058 13.3 0.5 8 6.3 0.0 2.5 2 0 0 2 2 2 0 NTPase IstB_IS21 PF01695.17 EDN10734.1 - 0.079 12.7 0.0 0.25 11.1 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein CbiA PF01656.23 EDN10734.1 - 0.14 12.2 0.0 0.44 10.6 0.0 1.9 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RVT_2 PF07727.14 EDN10736.1 - 2.2e-43 148.7 0.0 3.1e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_12 PF13087.6 EDN10737.1 - 5.5e-33 114.3 0.0 1.3e-32 113.1 0.0 1.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EDN10737.1 - 0.0095 15.7 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 EDN10737.1 - 0.079 12.3 0.0 0.83 9.0 0.0 2.0 1 1 0 2 2 2 0 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EDN10737.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Aldo_ket_red PF00248.21 EDN10738.1 - 4.4e-18 65.5 0.1 1.2e-16 60.7 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Oxidored_molyb PF00174.19 EDN10739.1 - 2.5e-56 190.0 0.1 9.5e-56 188.1 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EDN10739.1 - 2e-34 118.5 0.3 2e-34 118.5 0.3 2.5 3 0 0 3 3 3 1 Mo-co oxidoreductase dimerisation domain FAD_binding_6 PF00970.24 EDN10739.1 - 7.8e-19 67.9 0.0 1.4e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EDN10739.1 - 5.3e-18 65.6 0.1 4.2e-17 62.8 0.0 2.5 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EDN10739.1 - 5e-15 55.4 0.1 1.3e-14 54.1 0.1 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EDN10739.1 - 0.032 14.3 0.2 0.14 12.3 0.0 2.2 2 1 1 3 3 3 0 Ferric reductase NAD binding domain DUF4637 PF15470.6 EDN10739.1 - 0.23 11.2 9.8 0.6 9.8 9.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) BTRD1 PF17660.1 EDN10740.1 - 1.1e-85 281.3 7.5 1.3e-19 69.7 0.1 5.0 5 0 0 5 5 5 5 Bacterial tandem repeat domain 1 FAINT PF04385.15 EDN10740.1 - 0.027 14.5 0.0 2.1 8.4 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function, DUF529 MucBP_2 PF17965.1 EDN10740.1 - 0.029 14.9 0.3 17 6.1 0.0 2.9 3 0 0 3 3 3 0 Mucin binding domain Sugar_tr PF00083.24 EDN10741.1 - 1.2e-59 202.4 10.1 1.4e-59 202.2 10.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN10741.1 - 1.6e-08 33.9 32.3 6.1e-06 25.4 10.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RhoGAP PF00620.27 EDN10743.1 - 8.2e-36 123.1 0.0 1.4e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain mRNA_decap_C PF16741.5 EDN10743.1 - 0.26 10.6 1.3 0.62 9.4 1.3 1.5 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus Beta_elim_lyase PF01212.21 EDN10744.1 - 8.4e-63 212.4 0.0 1.2e-62 211.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDN10744.1 - 2.1e-05 24.0 0.0 0.0063 15.9 0.0 2.3 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EDN10744.1 - 0.027 13.0 0.0 0.41 9.1 0.0 2.1 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDN10744.1 - 0.13 11.1 0.0 0.44 9.4 0.0 1.7 1 1 0 1 1 1 0 Aminotransferase class-V ADH_N PF08240.12 EDN10745.1 - 1.3e-18 66.9 0.4 3.4e-18 65.5 0.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDN10745.1 - 2.1e-18 66.5 0.3 4.2e-18 65.6 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 EDN10745.1 - 0.0013 18.9 0.1 0.0024 18.1 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EDN10745.1 - 0.0042 16.4 0.8 0.0079 15.5 0.8 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EDN10745.1 - 0.052 13.1 0.3 0.088 12.4 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Imm70 PF15601.6 EDN10745.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 70 LIM PF00412.22 EDN10746.1 - 0.32 11.3 1.2 0.57 10.5 0.1 1.8 2 0 0 2 2 2 0 LIM domain zf_UBZ PF18439.1 EDN10746.1 - 0.56 9.9 0.0 0.56 9.9 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DEAD PF00270.29 EDN10747.1 - 1.6e-34 119.2 0.2 4.9e-34 117.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN10747.1 - 1.7e-23 83.1 0.2 4.5e-23 81.7 0.2 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EDN10747.1 - 0.025 13.9 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 EDN10747.1 - 0.05 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3217 PF11506.8 EDN10747.1 - 0.066 13.2 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) Peptidase_M10_C PF08548.11 EDN10747.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase M10 serralysin C terminal SH3_9 PF14604.6 EDN10748.1 - 4.5e-25 87.2 0.6 8.3e-13 48.0 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EDN10748.1 - 1.4e-23 82.9 0.1 1.4e-23 82.9 0.1 2.3 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EDN10748.1 - 1.2e-16 60.1 0.2 5.3e-07 29.2 0.1 2.5 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 EDN10748.1 - 3.4e-15 55.7 5.2 5.6e-15 55.0 5.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.17 EDN10748.1 - 0.00039 20.1 0.2 0.17 11.6 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_10 PF17902.1 EDN10748.1 - 0.00094 19.2 0.0 0.085 12.9 0.0 2.7 2 0 0 2 2 2 1 SH3 domain C1_2 PF03107.16 EDN10748.1 - 0.011 16.0 4.9 0.021 15.2 4.9 1.4 1 0 0 1 1 1 0 C1 domain SH3_3 PF08239.11 EDN10748.1 - 0.11 12.8 0.2 1.4 9.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain FYVE PF01363.21 EDN10748.1 - 0.39 10.9 4.1 0.85 9.8 4.1 1.5 1 0 0 1 1 1 0 FYVE zinc finger Glyco_hydro_72 PF03198.14 EDN10749.1 - 2.8e-131 437.5 0.9 3.6e-131 437.1 0.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EDN10749.1 - 2.5e-06 27.2 0.2 9.5e-06 25.2 0.2 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) GAF_2 PF13185.6 EDN10750.1 - 9.9e-05 22.7 0.0 0.00012 22.4 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EDN10750.1 - 0.0057 17.3 0.0 0.0064 17.1 0.0 1.2 1 0 0 1 1 1 1 GAF domain NAD_kinase PF01513.21 EDN10751.1 - 9.9e-76 254.7 0.0 1.1e-75 254.5 0.0 1.0 1 0 0 1 1 1 1 ATP-NAD kinase ODV-E18 PF10717.9 EDN10752.1 - 0.061 13.2 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 RNase_PH PF01138.21 EDN10753.1 - 0.025 15.1 0.0 0.043 14.3 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 1 Glyco_hydro_56 PF01630.18 EDN10753.1 - 0.11 11.4 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Hyaluronidase E1-E2_ATPase PF00122.20 EDN10754.1 - 5.7e-39 133.5 15.9 3e-32 111.6 0.1 3.2 2 1 1 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 EDN10754.1 - 4.6e-18 66.3 0.0 5.5e-17 62.8 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDN10754.1 - 1.8e-15 56.3 0.0 4.1e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EDN10754.1 - 7e-13 48.5 0.0 1.5e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDN10754.1 - 1.7e-06 28.0 2.8 9.6e-06 25.5 1.9 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EDN10754.1 - 0.029 14.2 1.6 0.058 13.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) IncE PF17627.2 EDN10754.1 - 1.1 9.3 5.6 0.5 10.4 2.1 2.3 2 0 0 2 2 2 0 Inclusion membrane protein E Cation_ATPase_C PF00689.21 EDN10755.1 - 1.3e-14 54.3 2.0 2e-14 53.7 2.0 1.3 1 1 0 1 1 1 1 Cation transporting ATPase, C-terminus MgtE PF01769.16 EDN10755.1 - 0.021 15.2 0.1 0.021 15.2 0.1 1.8 2 0 0 2 2 2 0 Divalent cation transporter DUF2014 PF09427.10 EDN10757.1 - 4.1e-103 344.3 0.9 5.5e-103 343.9 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 EDN10757.1 - 6.9e-17 61.2 0.5 6.9e-17 61.2 0.5 2.3 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.21 EDN10757.1 - 0.0071 16.4 1.7 0.0071 16.4 1.7 1.8 2 0 0 2 2 2 1 bZIP transcription factor ZapB PF06005.12 EDN10757.1 - 0.4 11.1 5.9 0.22 12.0 3.1 1.9 2 0 0 2 2 2 0 Cell division protein ZapB bZIP_2 PF07716.15 EDN10757.1 - 0.91 9.7 6.1 0.52 10.4 3.1 2.0 2 0 0 2 2 2 0 Basic region leucine zipper TSC22 PF01166.18 EDN10757.1 - 1.1 9.7 3.6 1.9 8.9 1.8 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family DHDPS PF00701.22 EDN10758.1 - 4.3e-42 143.8 0.0 5.4e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family SPOC PF07744.13 EDN10758.1 - 0.2 11.6 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 SPOC domain DUF4470 PF14737.6 EDN10759.1 - 1.7e-15 57.0 0.1 6.7e-15 55.1 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 EDN10759.1 - 6.3e-09 35.8 13.9 1.5e-08 34.5 13.9 1.7 1 0 0 1 1 1 1 MYND finger MFS_1 PF07690.16 EDN10760.1 - 1.4e-20 73.6 25.2 1.6e-11 43.8 14.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily CRPA PF05745.11 EDN10760.1 - 0.69 9.9 8.1 0.11 12.6 2.5 2.1 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Pectate_lyase_3 PF12708.7 EDN10761.1 - 9.5e-46 156.3 10.2 1e-45 156.2 6.4 2.5 2 0 0 2 2 2 1 Pectate lyase superfamily protein Varsurf_PPLC PF03490.13 EDN10761.1 - 0.0019 18.1 0.1 0.0058 16.6 0.1 1.8 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C SQHop_cyclase_N PF13249.6 EDN10761.1 - 0.031 13.4 0.0 4.2 6.4 0.0 2.3 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain MAGE_N PF12440.8 EDN10762.1 - 0.033 14.8 2.1 0.092 13.4 2.1 1.8 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal DUF2235 PF09994.9 EDN10762.1 - 0.068 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) ARL6IP6 PF15062.6 EDN10763.1 - 0.034 14.3 2.7 0.34 11.1 0.3 2.6 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix Mito_carr PF00153.27 EDN10764.1 - 2e-28 98.2 0.1 2.5e-18 65.8 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Pex24p PF06398.11 EDN10766.1 - 1.5e-57 195.3 0.0 1.8e-57 195.0 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin K1 PF02960.14 EDN10766.1 - 0.0041 17.2 0.0 0.0067 16.5 0.0 1.2 1 0 0 1 1 1 1 K1 glycoprotein Fig1 PF12351.8 EDN10766.1 - 0.042 13.8 0.3 0.067 13.1 0.3 1.3 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 RVT_2 PF07727.14 EDN10767.1 - 1.8e-33 116.2 0.0 2.8e-17 63.2 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN10767.1 - 2.3e-12 47.2 0.1 6.4e-12 45.7 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 EDN10767.1 - 0.029 14.1 3.0 0.059 13.1 3.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger gag_pre-integrs PF13976.6 EDN10767.1 - 0.038 13.9 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 EDN10767.1 - 0.11 12.3 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Retrotran_gag_2 PF14223.6 EDN10767.1 - 0.14 11.9 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Blt1 PF12754.7 EDN10768.1 - 7.4e-66 221.1 0.1 1.3e-65 220.3 0.0 1.4 2 0 0 2 2 2 1 Blt1 N-terminal domain Blt1_C PF17183.4 EDN10768.1 - 2.1e-22 78.5 2.5 3.4e-22 77.8 2.5 1.4 1 0 0 1 1 1 1 Get5 carboxyl domain Nop16 PF09420.10 EDN10770.1 - 4e-67 226.3 11.0 4.6e-67 226.1 11.0 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 ELP6 PF09807.9 EDN10772.1 - 0.0015 18.0 0.1 0.0016 17.9 0.1 1.3 1 1 0 1 1 1 1 Elongation complex protein 6 APH_6_hur PF04655.14 EDN10772.1 - 0.14 11.6 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase RdRP PF05183.12 EDN10773.1 - 6.6e-93 312.3 0.2 8.9e-93 311.9 0.2 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase FAD-oxidase_C PF02913.19 EDN10774.1 - 1.6e-61 208.1 0.0 2.2e-61 207.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDN10774.1 - 6.9e-35 119.8 0.0 1.6e-34 118.7 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Rep_1B PF17873.1 EDN10774.1 - 0.057 13.3 1.4 1.6 8.7 0.3 2.5 2 0 0 2 2 2 0 Replicase polyprotein 1ab Ribosomal_S4e PF00900.20 EDN10776.1 - 2.3e-37 126.7 0.1 5e-37 125.7 0.1 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EDN10776.1 - 7.1e-24 83.2 0.0 1.3e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EDN10776.1 - 1.5e-18 66.6 6.9 2.8e-18 65.7 6.9 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 EDN10776.1 - 3.8e-06 26.5 0.0 7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EDN10776.1 - 0.00027 20.8 0.9 0.00027 20.8 0.9 3.1 4 0 0 4 4 4 1 KOW motif Sipho_tail PF05709.11 EDN10776.1 - 0.051 13.0 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Phage tail protein Myb_DNA-bind_6 PF13921.6 EDN10778.1 - 6e-13 48.8 0.2 1.2e-05 25.5 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN10778.1 - 1.5e-11 44.3 1.0 2.3e-08 34.1 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EDN10778.1 - 0.03 14.3 0.0 0.065 13.3 0.0 1.6 1 0 0 1 1 1 0 SLIDE PX PF00787.24 EDN10779.1 - 3.2e-27 94.8 0.2 3.7e-27 94.6 0.2 1.1 1 0 0 1 1 1 1 PX domain WD40 PF00400.32 EDN10780.1 - 5.3e-18 65.0 25.1 8.3e-05 23.3 0.3 7.6 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10780.1 - 0.0012 19.1 0.1 0.086 13.1 0.0 3.7 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EDN10780.1 - 0.014 13.9 6.1 0.2 10.2 0.2 4.0 3 1 1 5 5 5 0 Cytochrome D1 heme domain PD40 PF07676.12 EDN10780.1 - 0.17 11.8 0.0 0.17 11.8 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EDN10780.1 - 0.39 10.0 0.8 7.4 5.8 0.0 2.5 3 0 0 3 3 3 0 WD40-like domain SecE PF00584.20 EDN10781.1 - 2.6e-14 52.9 0.0 3e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex RRM_1 PF00076.22 EDN10782.1 - 3.9e-05 23.4 0.0 6.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EDN10782.1 - 0.0081 16.4 0.5 0.014 15.7 0.5 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PSP1 PF04468.12 EDN10782.1 - 0.17 12.2 0.0 0.27 11.6 0.0 1.2 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Pyr_redox_3 PF13738.6 EDN10783.1 - 1.3e-09 37.7 0.0 0.0013 18.1 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN10783.1 - 8.8e-09 35.0 0.0 0.045 13.0 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN10783.1 - 0.0001 22.5 0.0 0.00064 19.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EDN10783.1 - 0.00024 20.5 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FMO-like PF00743.19 EDN10783.1 - 0.00079 18.0 0.7 0.094 11.1 0.0 2.4 2 1 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox PF00070.27 EDN10783.1 - 0.0044 17.6 0.0 0.72 10.5 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDN10783.1 - 0.014 15.9 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding K_oxygenase PF13434.6 EDN10783.1 - 0.062 12.4 0.0 1.9 7.5 0.0 2.7 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EDN10783.1 - 0.078 11.7 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Shikimate_DH PF01488.20 EDN10783.1 - 0.082 13.0 0.0 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EDN10783.1 - 0.1 11.8 0.0 0.61 9.3 0.0 2.0 2 0 0 2 2 2 0 Thi4 family DAO PF01266.24 EDN10783.1 - 0.17 11.5 0.0 0.48 9.9 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDN10783.1 - 0.21 10.6 0.0 0.37 9.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Mito_carr PF00153.27 EDN10786.1 - 8.7e-73 240.4 2.3 1.6e-23 82.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L21e PF01157.18 EDN10787.1 - 1e-27 96.0 1.6 1e-27 96.0 1.6 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e S4 PF01479.25 EDN10788.1 - 4.9e-12 45.4 1.3 4.9e-12 45.4 1.3 2.6 4 0 0 4 4 4 1 S4 domain Ribosomal_S4 PF00163.19 EDN10788.1 - 3e-06 28.0 0.9 5.4e-06 27.2 0.9 1.8 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DOPA_dioxygen PF08883.11 EDN10790.1 - 7.4e-41 138.7 0.1 9.4e-41 138.3 0.1 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family Vps62 PF06101.11 EDN10791.1 - 6.4e-16 57.8 1.4 2.8e-10 39.2 0.5 2.0 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 FtsK_SpoIIIE PF01580.18 EDN10792.1 - 0.0012 18.2 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family G-alpha PF00503.20 EDN10792.1 - 0.024 13.8 0.0 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Dynamin_N PF00350.23 EDN10792.1 - 0.064 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA_16 PF13191.6 EDN10792.1 - 0.14 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TRF PF08558.10 EDN10795.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EDN10795.1 - 0.024 14.9 0.0 0.061 13.5 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF484 PF04340.12 EDN10795.1 - 0.094 12.4 0.3 0.21 11.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF484 UPF0016 PF01169.19 EDN10796.1 - 1.4e-39 134.3 26.2 7.9e-20 71.0 7.5 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 CCDC24 PF15669.5 EDN10796.1 - 0.015 15.2 0.2 0.03 14.2 0.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PBP1_TM PF14812.6 EDN10797.1 - 0.092 13.1 4.2 0.28 11.6 4.2 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MFS_1 PF07690.16 EDN10798.1 - 7.6e-19 67.8 21.2 5.8e-10 38.6 3.1 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN10798.1 - 2e-06 26.9 0.1 2e-06 26.9 0.1 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter Pex14_N PF04695.13 EDN10798.1 - 0.0022 18.7 0.9 0.018 15.7 0.4 2.2 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Phage_holin_5_2 PF16079.5 EDN10798.1 - 1.8 8.9 4.0 1.5 9.2 0.5 2.6 2 1 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Gln-synt_C PF00120.24 EDN10799.1 - 1.5e-61 208.3 0.0 3.4e-61 207.1 0.0 1.6 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EDN10799.1 - 6.6e-14 52.4 0.0 1.2e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 EDN10799.1 - 0.0016 17.9 0.1 0.0056 16.1 0.0 2.0 3 0 0 3 3 3 1 TatD related DNase Aldedh PF00171.22 EDN10800.1 - 2.5e-125 418.6 0.7 1.1e-79 268.2 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family AA_permease_2 PF13520.6 EDN10801.1 - 8.1e-13 48.0 8.1 1.1e-12 47.5 8.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDN10801.1 - 2.1e-05 23.3 6.2 2.9e-05 22.8 6.2 1.1 1 0 0 1 1 1 1 Amino acid permease CbtA PF09490.10 EDN10801.1 - 0.035 13.9 2.1 0.91 9.2 0.2 2.3 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) DUF2207 PF09972.9 EDN10801.1 - 2 7.1 3.6 2.6 6.7 1.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ground-like PF04155.18 EDN10802.1 - 1.7 9.3 4.9 18 6.1 1.3 2.9 2 0 0 2 2 2 0 Ground-like domain Fumble PF03630.14 EDN10803.1 - 5.4e-142 472.8 0.1 6.9e-142 472.5 0.1 1.1 1 0 0 1 1 1 1 Fumble GPI2 PF06432.11 EDN10804.1 - 4.9e-64 216.5 2.0 4.9e-64 216.5 2.0 2.0 2 0 0 2 2 2 2 Phosphatidylinositol N-acetylglucosaminyltransferase Glyoxal_oxid_N PF07250.11 EDN10805.1 - 4.5e-43 147.2 0.0 2.4e-42 144.8 0.0 2.2 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EDN10805.1 - 4.4e-24 84.6 0.1 8.1e-24 83.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) DEAD PF00270.29 EDN10806.1 - 7.7e-43 146.3 0.0 1.4e-42 145.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN10806.1 - 1.2e-26 93.3 0.0 1.3e-25 89.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EDN10806.1 - 0.0008 18.2 0.0 0.0011 17.8 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EDN10806.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UTP25 PF06862.12 EDN10806.1 - 0.081 11.7 0.0 1.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Polysacc_deac_1 PF01522.21 EDN10807.1 - 1.7e-18 66.7 0.0 2.9e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DFP PF04127.15 EDN10808.1 - 1.1e-12 48.2 0.0 1e-05 25.4 0.0 3.2 3 0 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein Atg29_N PF18388.1 EDN10809.1 - 5.1e-23 80.7 0.1 8.8e-23 79.9 0.1 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain Herpes_UL6 PF01763.16 EDN10810.1 - 0.0047 15.5 0.7 0.0075 14.8 0.5 1.5 1 1 0 1 1 1 1 Herpesvirus UL6 like CENP-O PF09496.10 EDN10811.1 - 6.5e-63 212.5 0.0 1e-62 211.9 0.0 1.3 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component Acetyltransf_3 PF13302.7 EDN10812.1 - 9.4e-32 110.6 0.0 1.1e-31 110.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDN10812.1 - 0.00014 22.1 0.0 0.014 15.6 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family STAG PF08514.11 EDN10813.1 - 1.3e-37 128.2 3.7 1.3e-37 128.2 3.7 3.5 4 0 0 4 4 4 1 STAG domain HEAT_2 PF13646.6 EDN10813.1 - 1.8e-06 28.2 0.1 0.057 13.8 0.0 3.0 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 EDN10813.1 - 0.0012 18.9 0.2 28 5.3 0.0 4.7 4 0 0 4 4 4 1 HEAT repeat TetR_C_31 PF17940.1 EDN10813.1 - 0.028 14.6 0.0 0.14 12.3 0.0 2.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HsbA PF12296.8 EDN10813.1 - 4.1 7.9 6.9 1.5 9.3 0.2 3.0 3 0 0 3 3 3 0 Hydrophobic surface binding protein A Acatn PF13000.7 EDN10814.1 - 4.4e-111 372.1 14.9 1.3e-51 175.7 0.3 3.1 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 MFS_1_like PF12832.7 EDN10814.1 - 0.0042 16.0 6.4 0.0074 15.2 6.4 1.3 1 0 0 1 1 1 1 MFS_1 like family UreD PF01774.17 EDN10815.1 - 7.5e-76 254.8 0.0 1e-75 254.4 0.0 1.2 1 0 0 1 1 1 1 UreD urease accessory protein GDPD_2 PF13653.6 EDN10816.1 - 0.14 12.7 0.5 0.26 11.8 0.5 1.5 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family ANAPC1 PF12859.7 EDN10816.1 - 0.36 11.4 1.3 15 6.2 0.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 DUF4604 PF15377.6 EDN10817.1 - 4 7.8 31.5 0.87 10.0 19.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) S1 PF00575.23 EDN10818.1 - 2.1e-20 72.8 3.0 3.2e-12 46.6 0.7 2.5 2 0 0 2 2 2 2 S1 RNA binding domain TPR_14 PF13428.6 EDN10818.1 - 1.4e-08 34.8 0.0 3.3 8.8 0.1 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDN10818.1 - 2.8e-07 30.9 0.0 0.67 10.5 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat PPR PF01535.20 EDN10818.1 - 5.3e-06 26.3 0.1 1.3 9.4 0.0 3.9 4 0 0 4 4 3 2 PPR repeat Suf PF05843.14 EDN10818.1 - 1.5e-05 25.1 1.2 0.19 11.7 0.2 3.4 2 1 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_6 PF13174.6 EDN10818.1 - 0.00033 21.1 0.2 23 5.9 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR_2 PF13041.6 EDN10818.1 - 0.0014 18.8 0.0 22 5.3 0.0 3.4 3 0 0 3 3 3 0 PPR repeat family NRDE-2 PF08424.10 EDN10818.1 - 0.0049 16.0 0.1 0.031 13.4 0.1 2.1 2 1 0 2 2 2 1 NRDE-2, necessary for RNA interference TPR_16 PF13432.6 EDN10818.1 - 0.01 16.5 0.0 67 4.2 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDN10818.1 - 0.021 14.9 1.8 6 7.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDN10818.1 - 0.027 14.5 0.1 1.3 9.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat CooT PF10133.9 EDN10818.1 - 0.046 14.0 0.2 0.13 12.6 0.2 1.8 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT TPR_8 PF13181.6 EDN10818.1 - 0.76 10.2 3.2 4.5 7.7 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat S1 PF00575.23 EDN10819.1 - 3.2e-25 88.3 6.7 3.9e-10 39.9 0.0 5.7 5 0 0 5 5 5 4 S1 RNA binding domain SGT1 PF07093.11 EDN10819.1 - 0.12 10.8 3.8 0.18 10.2 3.8 1.2 1 0 0 1 1 1 0 SGT1 protein WD40 PF00400.32 EDN10820.1 - 5.3e-16 58.7 5.7 0.00082 20.1 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10820.1 - 1.5e-07 31.6 0.0 0.0055 17.0 0.0 5.2 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EDN10820.1 - 0.0018 18.0 0.1 0.26 11.0 0.0 2.3 2 0 0 2 2 2 2 TUP1-like enhancer of split Ge1_WD40 PF16529.5 EDN10820.1 - 0.0046 16.0 0.1 3.4 6.6 0.0 3.0 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein MtrB_PioB PF11854.8 EDN10820.1 - 0.019 13.3 0.2 0.026 12.9 0.2 1.1 1 0 0 1 1 1 0 Putative outer membrane beta-barrel porin, MtrB/PioB WD40_like PF17005.5 EDN10820.1 - 0.027 13.8 0.0 0.059 12.7 0.0 1.5 1 0 0 1 1 1 0 WD40-like domain Cpn60_TCP1 PF00118.24 EDN10821.1 - 2.5e-151 504.6 19.8 2.9e-151 504.5 19.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ProRS-C_1 PF09180.11 EDN10822.1 - 2.5e-19 69.2 3.1 4.3e-19 68.5 2.5 1.7 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EDN10822.1 - 2.7e-18 66.5 0.0 4.7e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF1590 PF07629.11 EDN10824.1 - 0.04 13.7 0.2 0.096 12.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1590) SKICH PF17751.1 EDN10826.1 - 0.0011 19.5 0.1 0.066 13.8 0.1 2.4 1 1 0 1 1 1 1 SKICH domain HECW_N PF16562.5 EDN10826.1 - 0.0012 18.6 0.1 0.0035 17.1 0.1 1.8 2 0 0 2 2 2 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 PEMT PF04191.13 EDN10827.1 - 6e-17 62.0 2.3 1.2e-16 61.0 2.3 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase Pkinase_fungal PF17667.1 EDN10828.1 - 4.9e-97 325.3 0.0 4.2e-78 262.9 0.0 2.1 1 1 1 2 2 2 2 Fungal protein kinase MauJ PF17419.2 EDN10828.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Methylamine utilization protein MauJ MFS_1 PF07690.16 EDN10829.1 - 3.7e-13 49.1 25.0 7.9e-13 48.1 24.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2530 PF10745.9 EDN10829.1 - 0.12 12.6 4.3 0.59 10.4 0.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2530) p450 PF00067.22 EDN10830.1 - 4.8e-23 81.6 0.0 1e-21 77.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Arginase PF00491.21 EDN10831.1 - 2.9e-14 53.2 0.7 5.1e-10 39.3 0.1 2.1 1 1 1 2 2 2 2 Arginase family Arginase PF00491.21 EDN10832.1 - 8.2e-18 64.9 0.1 1.2e-17 64.4 0.1 1.1 1 0 0 1 1 1 1 Arginase family DUF1993 PF09351.10 EDN10833.1 - 1.1e-39 136.1 0.1 2.8e-24 86.1 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF1993) ketoacyl-synt PF00109.26 EDN10834.1 - 2e-57 194.7 0.6 1.8e-56 191.6 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EDN10834.1 - 3.2e-34 117.5 1.4 4.9e-34 116.9 0.4 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EDN10834.1 - 3.2e-05 23.4 0.5 0.00018 20.9 0.2 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDN10834.1 - 0.005 16.5 2.1 0.26 10.9 0.4 3.5 3 1 0 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EDN10834.1 - 0.15 11.9 1.2 6.4 6.7 0.0 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SCA7 PF08313.12 EDN10835.1 - 4.6e-31 106.5 0.3 1.4e-30 104.9 0.3 1.9 1 1 0 1 1 1 1 SCA7, zinc-binding domain OrsD PF12013.8 EDN10835.1 - 0.072 13.5 2.9 0.21 12.0 0.6 2.5 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D CDC45 PF02724.14 EDN10835.1 - 0.44 8.8 8.3 0.62 8.3 8.3 1.2 1 0 0 1 1 1 0 CDC45-like protein mRNA_cap_enzyme PF01331.19 EDN10836.1 - 9e-51 172.5 0.1 1.2e-50 172.0 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EDN10836.1 - 1.8e-14 54.3 0.0 1.3e-12 48.3 0.0 2.4 1 1 1 2 2 2 2 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EDN10836.1 - 8.5e-09 35.3 0.2 1.4e-06 28.1 0.1 2.5 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EDN10836.1 - 0.0001 22.7 0.0 0.00018 21.9 0.0 1.4 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_N PF04675.14 EDN10837.1 - 7.7e-45 153.3 0.0 1.6e-44 152.3 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 EDN10837.1 - 4.2e-41 140.9 0.1 7.7e-41 140.0 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 EDN10837.1 - 1.9e-27 95.8 0.0 6e-27 94.2 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DUF4661 PF15576.6 EDN10837.1 - 2.1 8.2 9.5 3.9 7.3 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) SOBP PF15279.6 EDN10837.1 - 2.5 8.6 14.9 4.3 7.9 14.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Macoilin PF09726.9 EDN10837.1 - 5.7 5.4 13.9 9.5 4.6 13.9 1.3 1 0 0 1 1 1 0 Macoilin family XRCC4 PF06632.12 EDN10837.1 - 6.5 5.5 22.7 28 3.4 22.7 2.0 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CFEM PF05730.11 EDN10839.1 - 8.4e-09 35.4 6.6 1.4e-08 34.7 6.6 1.3 1 0 0 1 1 1 1 CFEM domain NPP PF08384.10 EDN10839.1 - 2 8.5 7.1 7.8 6.6 1.6 2.3 2 0 0 2 2 2 0 Pro-opiomelanocortin, N-terminal region Cu_amine_oxid PF01179.20 EDN10840.1 - 3.8e-120 401.6 1.1 4.6e-120 401.3 1.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EDN10840.1 - 4.2e-08 32.8 0.0 9.1e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 EDN10840.1 - 4e-06 27.0 0.0 9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain YidC_periplas PF14849.6 EDN10840.1 - 0.09 12.7 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 YidC periplasmic domain CAP_N PF01213.19 EDN10841.1 - 0.22 11.0 2.6 0.45 9.9 2.6 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal eIF-5_eIF-2B PF01873.17 EDN10842.1 - 1.2e-38 131.5 0.0 2.4e-38 130.6 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EDN10842.1 - 4.1e-22 78.1 0.1 1.2e-21 76.6 0.1 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon AP3D1 PF06375.11 EDN10842.1 - 0.0031 17.8 8.0 0.0031 17.8 8.0 2.1 2 0 0 2 2 2 1 AP-3 complex subunit delta-1 TMP-TENI PF02581.17 EDN10843.1 - 2.7e-58 196.3 0.5 4.9e-58 195.4 0.5 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase HK PF02110.15 EDN10843.1 - 1.6e-55 188.2 0.1 3.1e-55 187.2 0.1 1.4 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family ADH_zinc_N PF00107.26 EDN10843.1 - 0.013 15.5 0.7 0.11 12.5 0.1 2.7 2 1 1 3 3 3 0 Zinc-binding dehydrogenase PfkB PF00294.24 EDN10843.1 - 0.073 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 pfkB family carbohydrate kinase MCC-bdg_PDZ PF10506.9 EDN10843.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Isochorismatase PF00857.20 EDN10844.1 - 3.1e-23 82.8 0.0 4e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Lipase_GDSL_2 PF13472.6 EDN10845.1 - 8.3e-23 81.7 0.0 1.4e-22 81.0 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDN10845.1 - 3.3e-09 37.0 0.0 5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 EDN10845.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family gag-asp_proteas PF13975.6 EDN10846.1 - 0.13 12.8 1.3 0.77 10.4 0.0 2.6 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Cwf_Cwc_15 PF04889.12 EDN10847.1 - 4.8e-63 213.2 12.0 5.8e-63 212.9 12.0 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFAP1 PF06991.11 EDN10847.1 - 0.0017 18.2 11.0 0.0023 17.8 11.0 1.3 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing PA26 PF04636.13 EDN10847.1 - 0.39 9.6 2.7 0.43 9.4 2.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SAPS PF04499.15 EDN10847.1 - 8.5 5.0 8.2 10 4.8 8.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 EDN10847.1 - 8.9 4.5 14.7 10 4.2 14.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PhoLip_ATPase_C PF16212.5 EDN10848.1 - 2e-72 244.0 22.1 2e-72 244.0 22.1 2.6 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDN10848.1 - 4.3e-25 87.2 9.0 4.3e-25 87.2 9.0 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EDN10848.1 - 1.1e-05 25.1 0.0 3e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDN10848.1 - 0.0084 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDN10848.1 - 0.01 16.1 0.1 0.81 9.9 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase NicO PF03824.16 EDN10850.1 - 1.1e-29 103.7 18.5 4.7e-20 72.1 0.2 3.4 2 2 1 3 3 3 3 High-affinity nickel-transport protein Peptidase_M14 PF00246.24 EDN10852.1 - 1.3e-76 258.2 0.0 1.7e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase YL1 PF05764.13 EDN10852.1 - 5.8 7.0 9.5 10 6.1 9.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein CorA PF01544.18 EDN10853.1 - 1.7e-06 27.6 0.0 3.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Sec7 PF01369.20 EDN10854.1 - 2.2e-30 105.7 0.1 3.3e-30 105.1 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain zf-C2H2 PF00096.26 EDN10855.1 - 8.2 7.1 7.4 1.6 9.4 0.8 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF2167 PF09935.9 EDN10856.1 - 0.044 12.9 0.5 0.061 12.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) RVT_2 PF07727.14 EDN10858.1 - 3.1e-36 125.3 0.0 8.1e-21 74.8 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 EDN10858.1 - 2.6e-11 43.2 0.1 6.2e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EDN10858.1 - 0.00033 20.8 0.0 0.00097 19.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain DUF2845 PF11006.8 EDN10858.1 - 0.14 12.3 0.0 0.67 10.1 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) DDE_1 PF03184.19 EDN10859.1 - 5.9e-12 45.6 0.0 3.7e-09 36.5 0.0 3.3 3 1 1 4 4 4 2 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EDN10859.1 - 0.001 18.7 9.8 0.0024 17.5 1.7 2.4 2 0 0 2 2 2 2 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EDN10859.1 - 0.02 14.8 0.3 0.23 11.4 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN10859.1 - 0.07 12.9 0.5 0.07 12.9 0.5 1.9 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EDN10859.1 - 0.12 12.5 1.4 0.22 11.7 1.4 1.4 1 0 0 1 1 1 0 Zinc knuckle Defensin_2 PF01097.18 EDN10860.1 - 5.3e-07 29.5 3.2 8.8e-07 28.8 3.2 1.3 1 0 0 1 1 1 1 Arthropod defensin zf-NOSIP PF15906.5 EDN10861.1 - 0.00017 21.6 0.0 0.00026 21.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein CDC45 PF02724.14 EDN10861.1 - 0.34 9.2 5.9 0.42 8.8 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 EDN10863.1 - 1.6e-16 60.4 12.7 5.2e-16 58.8 12.7 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter ABA_GPCR PF12430.8 EDN10863.1 - 1.4 8.7 7.6 0.12 12.1 2.7 1.8 2 0 0 2 2 2 0 Abscisic acid G-protein coupled receptor DUF2040 PF09745.9 EDN10864.1 - 5.2e-36 123.4 19.7 5.2e-36 123.4 19.7 4.1 3 2 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) DUF3600 PF12207.8 EDN10864.1 - 0.0062 16.5 0.4 0.012 15.6 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3600) Sedlin_N PF04628.13 EDN10865.1 - 4e-11 43.1 0.0 4.5e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Peptidase_M13_N PF05649.13 EDN10865.1 - 0.18 11.5 0.0 0.21 11.2 0.0 1.0 1 0 0 1 1 1 0 Peptidase family M13 Isochorismatase PF00857.20 EDN10867.1 - 1.6e-30 106.6 0.0 3.2e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Isochorismatase family FAR1 PF03101.15 EDN10867.1 - 2.4e-05 24.9 0.0 4.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.11 EDN10867.1 - 0.04 14.3 0.0 0.069 13.6 0.0 1.3 1 0 0 1 1 1 0 Transcription factor AFT Phage_T7_tail PF03906.14 EDN10867.1 - 0.088 12.5 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Phage T7 tail fibre protein NUDE_C PF04880.13 EDN10868.1 - 2.7e-62 210.4 9.2 2.7e-62 210.4 9.2 2.4 2 1 1 3 3 3 1 NUDE protein, C-terminal conserved region ZapB PF06005.12 EDN10868.1 - 0.00084 19.7 8.4 0.00084 19.7 8.4 4.0 1 1 2 3 3 3 1 Cell division protein ZapB ATG16 PF08614.11 EDN10868.1 - 0.00085 19.6 26.5 0.0028 17.9 26.6 1.8 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) ERM PF00769.19 EDN10868.1 - 0.0021 17.9 12.6 0.0021 17.9 12.6 1.9 1 1 1 2 2 2 2 Ezrin/radixin/moesin family PSII_Pbs27 PF13326.6 EDN10868.1 - 0.1 12.9 4.9 0.19 12.1 4.9 1.4 1 0 0 1 1 1 0 Photosystem II Pbs27 TPR_MLP1_2 PF07926.12 EDN10868.1 - 0.19 11.8 31.9 0.81 9.7 9.7 3.3 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EDN10868.1 - 0.42 10.6 31.1 2.6 8.1 26.3 2.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 EDN10868.1 - 0.43 11.5 24.9 0.14 13.1 9.7 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Fmp27_WPPW PF10359.9 EDN10868.1 - 0.59 8.9 17.4 0.73 8.6 9.4 2.3 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Fez1 PF06818.15 EDN10868.1 - 0.9 10.0 24.2 3.9 7.9 12.5 2.4 1 1 1 2 2 2 0 Fez1 V_ATPase_I PF01496.19 EDN10868.1 - 1.1 7.0 11.0 0.26 9.2 4.0 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.7 EDN10868.1 - 1.3 9.1 33.1 0.4 10.8 0.4 3.6 1 1 2 3 3 3 0 Tropomyosin like Leu_zip PF15294.6 EDN10868.1 - 1.5 8.3 24.2 6.7 6.1 4.7 2.4 1 1 1 2 2 2 0 Leucine zipper Chibby PF14645.6 EDN10868.1 - 1.8 9.0 10.7 1.3 9.5 3.2 2.5 1 1 1 2 2 2 0 Chibby family APG6_N PF17675.1 EDN10868.1 - 2 9.0 38.9 0.3 11.6 9.8 3.1 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF724 PF05266.14 EDN10868.1 - 3 7.6 23.7 6.8 6.5 6.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3584 PF12128.8 EDN10868.1 - 7.5 3.9 24.2 11 3.4 24.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) IFT57 PF10498.9 EDN10868.1 - 8.5 5.2 20.8 0.047 12.7 8.9 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 UPF0242 PF06785.11 EDN10868.1 - 8.5 6.4 30.6 1.8 8.6 13.4 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EDN10868.1 - 8.6 6.4 29.3 6.6 6.8 9.6 3.3 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 EDN10868.1 - 8.9 5.3 27.2 13 4.8 10.5 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 EDN10868.1 - 9.1 7.0 20.0 0.32 11.6 5.2 2.8 1 1 1 2 2 2 0 Initiation control protein YabA ACC_central PF08326.12 EDN10869.1 - 4.3e-75 253.4 6.1 6.5e-44 150.3 0.1 3.1 1 1 2 3 3 3 3 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 EDN10869.1 - 5.7e-52 176.3 0.0 1e-51 175.4 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EDN10869.1 - 8.6e-22 77.3 0.0 3.1e-18 65.8 0.0 2.6 2 0 0 2 2 2 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EDN10869.1 - 5.5e-18 64.6 0.2 2.2e-17 62.7 0.1 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_carb_N PF00289.22 EDN10869.1 - 5.1e-17 62.4 0.0 9.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain ATP-grasp_3 PF02655.14 EDN10869.1 - 0.00015 21.9 0.0 0.0005 20.2 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDN10869.1 - 0.0005 19.7 0.0 0.0011 18.5 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 EDN10869.1 - 0.0093 15.8 0.1 0.071 12.9 0.0 2.5 3 0 0 3 3 3 1 Biotin-lipoyl like ATPgrasp_Ter PF15632.6 EDN10869.1 - 0.032 14.0 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Carboxyl_trans PF01039.22 EDN10870.1 - 4.6e-191 635.8 0.0 8e-191 635.0 0.0 1.4 2 0 0 2 2 2 1 Carboxyl transferase domain ACC_central PF08326.12 EDN10870.1 - 6.1e-98 328.9 0.0 9.1e-98 328.3 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region HeLo PF14479.6 EDN10871.1 - 9.8e-05 22.3 2.1 0.00012 22.0 0.5 1.9 2 1 0 2 2 2 1 Prion-inhibition and propagation Pkinase_Tyr PF07714.17 EDN10871.1 - 0.025 13.9 0.1 0.082 12.2 0.1 1.7 1 1 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 EDN10871.1 - 0.21 10.9 0.1 0.74 9.1 0.1 1.8 1 1 0 1 1 1 0 Protein kinase domain CBP_BcsF PF11120.8 EDN10872.1 - 0.22 11.7 2.7 14 5.9 0.1 2.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF TMEM208_SND2 PF05620.11 EDN10874.1 - 5.1e-51 172.8 0.0 8.1e-51 172.1 0.0 1.3 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 ANAPC3 PF12895.7 EDN10875.1 - 1.7e-25 89.1 10.0 1.5e-24 86.0 0.1 3.7 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EDN10875.1 - 1.3e-21 75.5 3.8 2e-07 30.6 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDN10875.1 - 2e-17 61.8 4.7 0.0011 18.9 0.0 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDN10875.1 - 2.1e-11 43.1 1.7 0.047 13.9 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDN10875.1 - 1.7e-10 41.0 7.3 0.043 14.1 0.1 5.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDN10875.1 - 2.8e-08 34.3 1.2 2.7 8.7 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDN10875.1 - 1.1e-07 31.4 0.2 0.011 15.4 0.0 4.8 4 1 2 6 6 6 2 TPR repeat TPR_14 PF13428.6 EDN10875.1 - 3e-07 30.7 5.0 3.8 8.6 0.0 6.0 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDN10875.1 - 9.4e-07 28.4 3.1 0.046 13.8 0.1 4.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDN10875.1 - 4.1e-06 27.2 2.2 0.14 12.6 0.0 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDN10875.1 - 0.00043 20.5 0.9 11 6.6 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDN10875.1 - 0.033 14.8 7.0 14 6.5 0.0 5.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDN10875.1 - 0.065 13.1 0.0 0.89 9.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDN10876.1 - 3.9e-10 39.3 1.7 0.01 15.5 0.1 3.2 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.17 EDN10876.1 - 4.7e-10 38.8 0.4 1.4e-06 27.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDN10876.1 - 3.6e-09 37.0 2.7 1.5e-07 31.8 0.8 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDN10876.1 - 1.9e-08 33.8 0.6 6.7e-06 25.7 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDN10876.1 - 2.9e-06 27.1 0.2 0.00087 19.3 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDN10876.1 - 2e-05 24.6 0.3 0.063 13.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDN10876.1 - 0.00014 22.4 0.6 0.65 11.0 0.1 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDN10876.1 - 0.0025 18.4 0.4 1.5 9.5 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDN10876.1 - 0.0059 16.8 0.6 0.009 16.2 0.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 APP_E2 PF12925.7 EDN10876.1 - 0.0063 16.2 0.3 0.0082 15.9 0.3 1.2 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein TPR_12 PF13424.6 EDN10876.1 - 0.013 15.8 0.1 0.2 12.0 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 EDN10876.1 - 0.019 14.2 0.2 0.065 12.4 0.1 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDN10876.1 - 0.019 15.1 0.2 1.4 9.1 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Ribos_L4_asso_C PF14374.6 EDN10876.1 - 0.024 14.7 1.1 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 60S ribosomal protein L4 C-terminal domain TPR_6 PF13174.6 EDN10876.1 - 0.064 13.9 0.6 0.76 10.5 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat ChAPs PF09295.10 EDN10876.1 - 0.085 11.8 0.1 0.089 11.8 0.1 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF3245 PF11595.8 EDN10876.1 - 0.13 12.7 0.0 0.16 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Acyltransferase PF01553.21 EDN10877.1 - 2.4e-31 108.1 0.0 4.2e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Paralemmin PF03285.15 EDN10877.1 - 0.059 12.9 0.9 0.079 12.5 0.9 1.1 1 0 0 1 1 1 0 Paralemmin XPB_DRD PF18458.1 EDN10877.1 - 0.071 13.0 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 Xeroderma pigmentosum group B helicase damage recognition domain ACPS PF01648.20 EDN10878.1 - 2.4e-11 43.8 0.0 4.3e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily SNO PF01174.19 EDN10879.1 - 1.8e-27 96.4 0.0 2e-27 96.3 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EDN10879.1 - 1.1e-07 31.6 0.0 1.2e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 EDN10879.1 - 0.0081 15.8 0.0 0.0089 15.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 EDN10879.1 - 0.034 14.0 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 DJ-1/PfpI family ThiJ_like PF17124.5 EDN10879.1 - 0.085 12.5 0.0 0.095 12.4 0.0 1.1 1 0 0 1 1 1 0 ThiJ/PfpI family-like RRM_1 PF00076.22 EDN10880.1 - 4.3e-15 55.3 0.0 5.9e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF948 PF06103.11 EDN10881.1 - 0.0033 17.6 0.2 4.9 7.5 0.0 2.9 2 1 0 2 2 2 2 Bacterial protein of unknown function (DUF948) Nup54 PF13874.6 EDN10881.1 - 0.17 12.0 1.4 1.5 8.9 0.1 2.6 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.12 EDN10881.1 - 0.86 10.1 2.4 9.5 6.8 0.0 3.3 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Rotamase PF00639.21 EDN10884.1 - 2.9e-22 79.4 0.0 4.5e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EDN10884.1 - 4.1e-14 53.1 0.0 5.6e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EDN10884.1 - 1.4e-09 37.9 2.1 1.4e-09 37.9 2.1 1.6 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EDN10884.1 - 0.00049 20.9 0.0 0.0006 20.6 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain MAPEG PF01124.18 EDN10885.1 - 3.1e-25 88.6 0.6 3.7e-25 88.3 0.6 1.1 1 0 0 1 1 1 1 MAPEG family MBOAT PF03062.19 EDN10887.1 - 3.2e-18 66.2 13.3 5.1e-18 65.5 13.3 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EDN10887.1 - 0.0011 19.1 2.3 0.0036 17.6 2.3 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF2530 PF10745.9 EDN10887.1 - 0.017 15.4 0.3 0.17 12.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Orf78 PF06024.12 EDN10887.1 - 0.027 14.8 0.1 0.24 11.7 0.1 2.4 2 0 0 2 2 2 0 Orf78 (ac78) WD40 PF00400.32 EDN10888.1 - 2e-20 72.7 32.3 1.4e-05 25.7 1.5 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN10888.1 - 3.3e-13 49.7 0.0 0.1 12.9 0.0 5.3 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDN10888.1 - 0.0048 16.8 0.1 2.6 7.9 0.0 3.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF3517 PF12030.8 EDN10891.1 - 9.7e-109 363.3 0.0 1.3e-108 362.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) TFIIE_alpha PF02002.17 EDN10892.1 - 3.8e-20 71.7 0.0 1.8e-19 69.5 0.0 2.0 2 0 0 2 2 2 1 TFIIE alpha subunit Zn-ribbon_8 PF09723.10 EDN10892.1 - 0.0013 18.8 0.5 0.0029 17.7 0.5 1.6 1 0 0 1 1 1 1 Zinc ribbon domain zf-CCHC_2 PF13696.6 EDN10892.1 - 0.0014 18.4 1.4 0.7 9.8 0.1 2.3 2 0 0 2 2 2 2 Zinc knuckle HTH_Crp_2 PF13545.6 EDN10892.1 - 0.038 14.0 0.1 0.072 13.1 0.1 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TF_Zn_Ribbon PF08271.12 EDN10892.1 - 0.046 13.2 0.6 0.32 10.6 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf_UBZ PF18439.1 EDN10892.1 - 0.076 12.6 0.6 15 5.3 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger HalOD2 PF18547.1 EDN10892.1 - 0.13 12.2 1.5 0.47 10.4 1.5 1.8 1 1 0 1 1 1 0 Halobacterial output domain 2 OrfB_Zn_ribbon PF07282.11 EDN10892.1 - 0.71 9.8 2.6 7 6.6 2.0 2.3 1 1 2 3 3 3 0 Putative transposase DNA-binding domain PseudoU_synth_1 PF01416.20 EDN10893.1 - 8.8e-10 39.0 0.0 2.9e-08 34.1 0.0 2.6 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF4512 PF14975.6 EDN10893.1 - 0.3 11.9 0.1 0.3 11.9 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4512) Anillin PF08174.11 EDN10894.1 - 1.6e-09 38.4 0.0 3.2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 EDN10894.1 - 2.6e-09 37.6 0.0 7.7e-09 36.0 0.0 1.8 1 1 0 1 1 1 1 PH domain Herpes_LMP1 PF05297.11 EDN10895.1 - 1.5 8.0 5.2 4.8 6.3 1.4 2.3 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) DEAD PF00270.29 EDN10896.1 - 3.9e-31 108.2 0.1 5.7e-31 107.6 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDN10896.1 - 6.9e-17 61.8 0.0 2.9e-14 53.3 0.0 2.8 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDN10896.1 - 2e-06 27.9 0.0 1.5e-05 25.1 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SET PF00856.28 EDN10897.1 - 4.5e-09 36.9 0.0 6e-09 36.5 0.0 1.4 1 1 0 1 1 1 1 SET domain Ribosomal_L14 PF00238.19 EDN10898.1 - 6e-45 152.3 1.0 6.6e-45 152.1 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e TFIIS_C PF01096.18 EDN10899.1 - 2.9e-15 55.8 3.1 2.9e-15 55.8 3.1 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EDN10899.1 - 1.3e-11 44.2 1.6 1.3e-11 44.2 1.6 3.0 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Lar_restr_allev PF14354.6 EDN10899.1 - 0.031 14.7 2.4 0.031 14.7 2.4 2.3 2 1 0 2 2 2 0 Restriction alleviation protein Lar GFA PF04828.14 EDN10899.1 - 2.1 8.7 12.2 0.18 12.1 0.9 2.9 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn-ribbon_8 PF09723.10 EDN10899.1 - 2.4 8.3 13.7 1.2 9.3 2.6 3.1 3 0 0 3 3 3 0 Zinc ribbon domain DUF3268 PF11672.8 EDN10899.1 - 4 7.8 8.6 1.3 9.4 2.2 2.2 2 1 0 2 2 2 0 zinc-finger-containing domain zf-CHY PF05495.12 EDN10899.1 - 4.6 7.8 12.1 42 4.7 12.1 2.3 1 1 1 2 2 2 0 CHY zinc finger OMPdecase PF00215.24 EDN10900.1 - 3.9e-52 177.1 0.0 5e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family APH PF01636.23 EDN10902.1 - 2.6e-15 57.0 0.1 5.8e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN10902.1 - 0.00029 20.5 0.2 0.0016 18.1 0.1 2.0 1 1 1 2 2 2 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EDN10902.1 - 0.12 11.6 0.0 0.5 9.5 0.0 1.8 2 0 0 2 2 2 0 Fructosamine kinase DivIC PF04977.15 EDN10903.1 - 0.0033 17.2 9.0 0.29 11.0 0.8 2.2 1 1 1 2 2 2 2 Septum formation initiator MscS_porin PF12795.7 EDN10903.1 - 0.0039 16.8 11.3 0.0041 16.7 11.3 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF3135 PF11333.8 EDN10903.1 - 0.0076 16.5 1.1 0.0076 16.5 1.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3135) DUF3502 PF12010.8 EDN10903.1 - 0.0081 16.8 0.1 0.0097 16.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) Alpha-2-MRAP_C PF06401.11 EDN10903.1 - 0.025 14.5 1.5 0.03 14.3 1.5 1.0 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF5082 PF16888.5 EDN10903.1 - 0.026 14.8 5.6 0.69 10.2 5.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) V-ATPase_G PF03179.15 EDN10903.1 - 0.027 15.0 0.6 0.027 15.0 0.6 2.0 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Spc7 PF08317.11 EDN10903.1 - 0.059 12.3 5.2 0.081 11.8 5.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 EDN10903.1 - 0.09 13.0 6.8 0.49 10.6 6.7 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4061 PF13270.6 EDN10903.1 - 0.099 13.0 4.5 0.15 12.4 4.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) Atg14 PF10186.9 EDN10903.1 - 0.12 11.5 4.5 0.13 11.3 4.5 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 EDN10903.1 - 0.18 11.9 6.0 0.2 11.7 6.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FliJ PF02050.16 EDN10903.1 - 0.19 12.0 9.3 0.25 11.5 9.3 1.2 1 0 0 1 1 1 0 Flagellar FliJ protein Fib_alpha PF08702.10 EDN10903.1 - 0.24 11.6 4.0 0.32 11.2 4.0 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 EDN10903.1 - 0.24 11.7 7.9 0.36 11.2 7.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-F_leu_zip PF10473.9 EDN10903.1 - 0.29 11.1 7.5 0.8 9.7 7.5 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin_2 PF01920.20 EDN10903.1 - 0.3 11.1 7.5 2.2 8.3 2.3 2.4 1 1 1 2 2 2 0 Prefoldin subunit KxDL PF10241.9 EDN10903.1 - 0.37 11.1 6.6 0.55 10.5 0.9 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein HIP1_clath_bdg PF16515.5 EDN10903.1 - 0.48 11.1 8.9 2.8 8.6 4.5 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2203 PF09969.9 EDN10903.1 - 0.52 11.0 3.4 1 10.1 3.4 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Bap31_Bap29_C PF18035.1 EDN10903.1 - 0.66 10.0 4.7 0.49 10.4 0.5 2.3 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Borrelia_orfD PF02999.14 EDN10904.1 - 0.03 14.6 0.4 0.039 14.3 0.4 1.4 1 0 0 1 1 1 0 Borrelia orf-D family Beta_helix_2 PF18835.1 EDN10904.1 - 0.044 13.5 2.4 0.098 12.4 2.4 1.5 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase DnaJ_C PF01556.18 EDN10911.1 - 1.6e-28 99.6 0.0 3.1e-28 98.7 0.0 1.5 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDN10911.1 - 6.4e-25 87.1 1.0 1.1e-24 86.3 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDN10911.1 - 3.4e-14 52.9 16.0 5.6e-14 52.2 16.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDN10911.1 - 2e-05 24.4 8.4 0.034 14.1 1.8 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDN10911.1 - 0.0047 16.9 6.8 0.41 10.7 0.8 2.2 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 EDN10911.1 - 0.075 13.4 11.2 0.11 12.9 1.6 2.7 2 1 1 3 3 3 0 Restriction alleviation protein Lar TackOD1 PF18551.1 EDN10911.1 - 1.1 8.8 6.6 0.74 9.4 0.3 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zinc-ribbons_6 PF07191.12 EDN10911.1 - 8.7 6.4 10.8 41 4.2 6.4 2.2 1 1 1 2 2 2 0 zinc-ribbons Malic_M PF03949.15 EDN10914.1 - 1.2e-90 303.3 0.1 1.5e-90 302.9 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EDN10914.1 - 4.1e-64 215.7 0.0 6.3e-64 215.1 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DBD_Tnp_Mut PF03108.15 EDN10915.1 - 0.0031 17.5 0.6 0.0066 16.4 0.6 1.5 1 0 0 1 1 1 1 MuDR family transposase THOC7 PF05615.13 EDN10916.1 - 2.4e-48 163.8 10.0 2.4e-48 163.8 10.0 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 CCDC92 PF14916.6 EDN10916.1 - 0.0084 15.9 1.7 0.022 14.5 1.7 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Peroxin-13_N PF04088.13 EDN10916.1 - 0.13 12.6 0.6 0.31 11.3 0.2 1.8 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Mod_r PF07200.13 EDN10916.1 - 0.34 11.0 14.3 0.095 12.8 10.7 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein LMBR1 PF04791.16 EDN10916.1 - 0.46 9.3 3.2 0.61 8.9 3.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF812 PF05667.11 EDN10916.1 - 9 5.0 18.4 27 3.5 18.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Ank_2 PF12796.7 EDN10917.1 - 1.4e-07 32.0 0.0 3.1e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN10917.1 - 1.6e-06 28.0 0.0 0.028 14.9 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EDN10917.1 - 4.7e-06 27.0 0.0 0.0008 19.9 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN10917.1 - 0.0017 18.7 0.5 8.6 7.0 0.0 4.7 4 1 1 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 EDN10917.1 - 0.011 16.0 0.0 0.043 14.1 0.0 2.0 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Tup_N PF08581.10 EDN10918.1 - 0.59 10.5 7.2 12 6.3 0.2 2.7 1 1 1 2 2 2 0 Tup N-terminal DUF3723 PF12520.8 EDN10919.1 - 5.1e-103 345.5 0.0 6.7e-103 345.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) NAD_binding_6 PF08030.12 EDN10920.1 - 7.8e-08 32.6 0.0 1.5e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDN10920.1 - 2e-07 31.0 0.0 3.9e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EDN10920.1 - 1.8 8.7 12.9 0.13 12.4 3.8 2.4 2 0 0 2 2 2 0 Ferric reductase like transmembrane component RVT_1 PF00078.27 EDN10923.1 - 8.6e-36 123.5 0.0 1.9e-35 122.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN10923.1 - 2.2e-27 95.3 0.1 1.9e-26 92.3 0.1 2.5 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN10923.1 - 3.2e-13 50.1 0.1 1.3e-12 48.1 0.1 2.1 1 0 0 1 1 1 1 RNase H Exo_endo_phos PF03372.23 EDN10923.1 - 0.0016 18.0 0.3 0.0059 16.1 0.1 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family HALZ PF02183.18 EDN10923.1 - 0.0086 16.3 2.0 0.0086 16.3 2.0 1.9 2 0 0 2 2 2 1 Homeobox associated leucine zipper ATG16 PF08614.11 EDN10923.1 - 0.014 15.6 1.3 0.042 14.1 1.3 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) YabA PF06156.13 EDN10923.1 - 0.11 13.1 0.2 0.46 11.1 0.2 2.1 1 0 0 1 1 1 0 Initiation control protein YabA Cnn_1N PF07989.11 EDN10923.1 - 0.16 12.1 1.1 0.52 10.5 1.1 1.8 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 THOC7 PF05615.13 EDN10923.1 - 0.19 12.0 2.9 0.27 11.5 0.7 2.4 2 0 0 2 2 2 0 Tho complex subunit 7 BST2 PF16716.5 EDN10923.1 - 0.45 11.1 4.3 1.4 9.6 4.3 1.8 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 DUF2841 PF11001.8 EDN10924.1 - 2.6e-49 166.4 0.5 4.2e-49 165.7 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Ebp2 PF05890.12 EDN10924.1 - 0.1 12.2 2.1 0.16 11.5 2.1 1.2 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 CENP-H PF05837.12 EDN10925.1 - 0.039 14.4 12.5 0.58 10.6 2.9 3.2 3 0 0 3 3 3 0 Centromere protein H (CENP-H) BofC_C PF08955.10 EDN10927.1 - 0.00011 22.1 0.0 18 5.5 0.0 4.1 2 2 2 4 4 4 4 BofC C-terminal domain MF_alpha PF04648.12 EDN10927.1 - 0.012 15.9 2.0 1.4e+02 3.0 0.0 4.6 4 0 0 4 4 4 0 Yeast mating factor alpha hormone Pkinase_fungal PF17667.1 EDN10928.1 - 1.8e-92 310.3 0.0 2.3e-92 309.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase TBCA PF02970.16 EDN10929.1 - 1.3e-15 57.5 2.2 1.5e-15 57.3 2.2 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A APC_N_CC PF16689.5 EDN10929.1 - 0.043 13.9 0.8 0.24 11.5 0.0 1.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Csm1_N PF18504.1 EDN10929.1 - 0.072 13.4 2.0 0.087 13.2 2.0 1.3 1 1 0 1 1 1 0 Csm1 N-terminal domain MFS_1 PF07690.16 EDN10930.1 - 1.5e-16 60.3 24.0 1.5e-16 60.3 24.0 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Band_7 PF01145.25 EDN10931.1 - 5.6e-16 59.0 0.0 5.6e-16 59.0 0.0 2.8 2 1 0 2 2 2 1 SPFH domain / Band 7 family Hemerythrin PF01814.23 EDN10932.1 - 6.5e-09 36.5 2.1 1.9e-08 35.0 1.9 1.9 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain DnaI_N PF07319.11 EDN10932.1 - 0.0098 16.5 0.2 1.2 9.8 0.0 2.3 2 1 0 2 2 2 2 Primosomal protein DnaI N-terminus ABC1 PF03109.16 EDN10932.1 - 0.11 12.7 0.1 4.6 7.4 0.0 2.2 2 0 0 2 2 2 0 ABC1 family DUF846 PF05832.12 EDN10933.1 - 0.033 14.2 0.3 0.037 14.1 0.3 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF846) Sugar_tr PF00083.24 EDN10934.1 - 1.6e-62 211.9 24.8 6.2e-62 209.9 24.8 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN10934.1 - 0.00066 18.7 38.0 0.0012 17.8 32.8 3.2 1 1 2 3 3 3 2 Major Facilitator Superfamily Elongin_A PF06881.11 EDN10935.1 - 4.1e-19 69.1 0.2 6.9e-19 68.3 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Cdh1_DBD_1 PF18196.1 EDN10935.1 - 0.1 12.9 0.1 0.24 11.7 0.1 1.5 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 PTN13_u3 PF16599.5 EDN10935.1 - 1 9.4 13.4 2.5 8.1 12.2 2.2 1 1 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ Ribosomal_L44 PF00935.19 EDN10936.1 - 2.5e-36 124.0 12.0 2.5e-36 124.0 12.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L44 CCDC106 PF15794.5 EDN10936.1 - 0.13 11.9 5.7 0.15 11.7 5.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Cathelicidins PF00666.17 EDN10936.1 - 0.18 12.1 4.5 0.21 11.9 1.0 2.0 2 0 0 2 2 2 0 Cathelicidin Vac7 PF12751.7 EDN10937.1 - 1.4e-149 498.7 0.2 1.9e-149 498.2 0.2 1.2 1 0 0 1 1 1 1 Vacuolar segregation subunit 7 DUF3824 PF12868.7 EDN10938.1 - 2.4e-39 135.4 57.0 3.7e-39 134.7 38.2 10.0 4 1 7 11 11 11 3 Domain of unknwon function (DUF3824) CorA PF01544.18 EDN10939.1 - 3.9e-22 78.9 0.0 5.9e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Integrase_H2C2 PF17921.1 EDN10942.1 - 9.3e-20 70.5 0.3 9.3e-20 70.5 0.3 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain Chromo PF00385.24 EDN10942.1 - 7.9e-15 54.5 3.0 2.2e-14 53.1 3.0 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 EDN10942.1 - 5.6e-13 49.1 0.0 1.3e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDN10942.1 - 0.00092 19.4 0.0 0.0021 18.2 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN10942.1 - 0.09 13.0 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Lipase_GDSL_2 PF13472.6 EDN10943.1 - 8.2e-12 45.9 0.2 1.1e-11 45.4 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.6 EDN10943.1 - 0.00025 21.2 0.0 0.00033 20.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDN10943.1 - 0.001 19.1 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Zn_clus PF00172.18 EDN10945.1 - 4.7e-12 45.8 12.2 7.9e-12 45.1 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gcn1_N PF12074.8 EDN10947.1 - 1.5e-43 149.5 7.4 1.1e-30 107.2 0.1 4.4 4 1 1 5 5 5 3 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Ribosomal_L19e PF01280.20 EDN10947.1 - 2.6e-35 121.6 0.2 5.3e-35 120.6 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L19e HEAT PF02985.22 EDN10947.1 - 1.2e-23 81.2 34.0 0.59 10.6 0.1 19.3 23 0 0 23 23 20 5 HEAT repeat HEAT_2 PF13646.6 EDN10947.1 - 6.3e-21 74.6 35.4 0.00076 19.8 0.0 12.3 5 2 9 14 14 14 7 HEAT repeats HEAT_EZ PF13513.6 EDN10947.1 - 1.7e-18 66.7 35.0 5.5e-06 26.8 0.0 16.4 17 3 2 19 19 18 3 HEAT-like repeat Cnd1 PF12717.7 EDN10947.1 - 3.6e-13 49.9 3.1 0.18 11.8 0.2 7.8 4 2 3 8 8 8 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDN10947.1 - 1.1e-10 42.0 0.3 0.048 14.3 0.1 7.0 6 2 1 7 7 6 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EDN10947.1 - 5.7e-08 32.6 0.0 3.3 7.2 0.0 6.3 4 2 1 6 6 6 2 CLASP N terminal ParcG PF10274.9 EDN10947.1 - 2.4e-07 31.0 1.5 0.47 10.5 0.0 5.7 6 1 1 7 7 6 2 Parkin co-regulated protein TIP120 PF08623.10 EDN10947.1 - 7e-07 29.2 0.0 0.0011 18.8 0.0 5.1 5 1 0 5 5 5 1 TATA-binding protein interacting (TIP20) RTP1_C1 PF10363.9 EDN10947.1 - 0.0022 18.2 6.1 12 6.1 0.0 6.9 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF937 PF06078.11 EDN10947.1 - 0.0092 16.6 6.2 4.1 8.0 0.0 5.4 3 2 0 3 3 3 1 Bacterial protein of unknown function (DUF937) Tti2 PF10521.9 EDN10947.1 - 0.078 12.5 6.1 5.7 6.4 0.0 5.8 6 1 0 6 6 6 0 Tti2 family DUF5059 PF16502.5 EDN10947.1 - 0.093 11.4 0.4 0.94 8.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5059) TFCD_C PF12612.8 EDN10947.1 - 0.12 12.2 0.0 1.3 8.9 0.0 2.9 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal HA2 PF04408.23 EDN10948.1 - 2.7e-16 59.8 0.0 7.6e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDN10948.1 - 1.4e-14 54.3 0.1 4.1e-14 52.8 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN10948.1 - 2.1e-10 40.6 0.0 5.7e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDN10948.1 - 1.2e-05 25.6 0.1 4e-05 23.9 0.1 1.9 1 0 0 1 1 1 1 AAA domain RuvA_C PF07499.13 EDN10948.1 - 1.2 9.7 4.2 1.8 9.1 0.1 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain BRCT_2 PF16589.5 EDN10949.1 - 3.5e-09 36.9 0.0 3.4e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EDN10949.1 - 0.0062 16.5 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain KilA-N PF04383.13 EDN10952.1 - 0.0037 17.1 0.0 0.0086 15.9 0.0 1.6 1 0 0 1 1 1 1 KilA-N domain Mg_trans_NIPA PF05653.14 EDN10953.1 - 9.4e-87 290.8 26.9 1.3e-86 290.3 26.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EDN10953.1 - 0.00013 22.2 6.7 0.00013 22.2 6.7 3.2 3 0 0 3 3 3 1 EamA-like transporter family GRA6 PF05084.13 EDN10953.1 - 3 7.8 7.6 17 5.3 1.8 3.5 2 2 1 3 3 3 0 Granule antigen protein (GRA6) Patatin PF01734.22 EDN10954.1 - 9.8e-15 55.3 0.0 1.9e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase MOSC PF03473.17 EDN10956.1 - 3.1e-20 72.5 0.0 7e-19 68.1 0.0 2.0 1 1 1 2 2 2 2 MOSC domain SHMT PF00464.19 EDN10957.1 - 5.4e-198 657.5 0.0 6.3e-198 657.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase AMP-binding PF00501.28 EDN10958.1 - 1.4e-64 218.3 0.0 1.9e-64 217.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EDN10958.1 - 5.1e-15 55.1 0.3 4.8e-14 52.0 0.1 2.2 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Ras PF00071.22 EDN10959.1 - 4.8e-32 110.8 0.1 2e-31 108.8 0.1 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDN10959.1 - 1.6e-06 28.3 0.0 5.2e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EDN10959.1 - 0.094 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B PRF PF06875.11 EDN10959.1 - 0.21 11.0 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF GST_N_2 PF13409.6 EDN10960.1 - 1e-20 73.8 0.0 2.2e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDN10960.1 - 1.6e-15 56.9 0.0 1.3e-14 53.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDN10960.1 - 7.4e-06 26.1 0.0 1.8e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDN10960.1 - 0.00055 20.3 0.0 0.006 17.0 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDN10960.1 - 0.0069 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Fez1 PF06818.15 EDN10962.1 - 0.0014 19.1 17.7 0.0024 18.4 17.7 1.3 1 0 0 1 1 1 1 Fez1 TPR_MLP1_2 PF07926.12 EDN10962.1 - 0.008 16.2 23.8 0.31 11.1 14.4 2.3 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein DUF641 PF04859.12 EDN10962.1 - 0.023 15.0 0.7 0.023 15.0 0.7 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) CorA PF01544.18 EDN10962.1 - 0.35 10.2 2.7 0.53 9.5 2.7 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein SlyX PF04102.12 EDN10962.1 - 0.4 11.3 7.6 4.8 7.9 7.6 2.5 1 1 0 1 1 1 0 SlyX Exonuc_VII_L PF02601.15 EDN10962.1 - 0.72 9.4 8.4 1.1 8.7 8.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Golgin_A5 PF09787.9 EDN10962.1 - 0.98 8.8 15.5 1.6 8.1 15.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF3584 PF12128.8 EDN10962.1 - 1.1 6.7 13.9 1.5 6.2 13.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 EDN10962.1 - 1.1 8.5 5.7 1.7 7.9 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 EDN10962.1 - 1.2 9.3 11.2 2.2 8.3 11.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 EDN10962.1 - 1.4 8.2 20.9 12 5.2 20.9 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF5466 PF17554.2 EDN10962.1 - 1.5 9.1 4.0 1.6 9.0 0.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5466) Csm1_N PF18504.1 EDN10962.1 - 5.1 7.5 12.5 3.5 8.1 0.7 3.4 1 1 2 3 3 3 0 Csm1 N-terminal domain DUF724 PF05266.14 EDN10962.1 - 6.5 6.5 13.3 20 4.9 13.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 EDN10962.1 - 6.8 6.9 6.8 2.5 8.3 1.6 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Mcp5_PH PF12814.7 EDN10963.1 - 2.6e-46 156.7 0.1 4.4e-46 156.0 0.1 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology CAF1A PF12253.8 EDN10963.1 - 0.021 15.0 0.1 0.052 13.7 0.1 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Cyt-b5 PF00173.28 EDN10964.1 - 6.3e-21 74.3 0.2 7.1e-21 74.1 0.2 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Helicase_C PF00271.31 EDN10965.1 - 8.6e-13 48.6 0.0 2.2e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDN10965.1 - 1.5e-06 28.1 0.0 2.5e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDN10965.1 - 3.7e-05 24.0 0.4 0.00026 21.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDN10965.1 - 7.9e-05 22.4 0.2 0.0002 21.1 0.2 1.7 1 0 0 1 1 1 1 AAA domain PWI PF01480.17 EDN10965.1 - 0.00021 21.5 0.0 0.00053 20.2 0.0 1.7 1 0 0 1 1 1 1 PWI domain T2SSE PF00437.20 EDN10965.1 - 0.00022 20.4 0.0 0.00048 19.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EDN10965.1 - 0.00035 20.9 0.2 0.00091 19.6 0.2 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EDN10965.1 - 0.001 18.7 0.3 0.0028 17.3 0.3 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.6 EDN10965.1 - 0.0092 16.1 0.1 0.048 13.8 0.0 2.2 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_23 PF13476.6 EDN10965.1 - 0.076 13.5 0.0 0.076 13.5 0.0 3.5 1 1 2 3 3 1 0 AAA domain DUF1770 PF08589.10 EDN10965.1 - 0.12 13.3 6.2 0.6 11.1 6.2 2.2 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1770) AAA_7 PF12775.7 EDN10965.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EDN10965.1 - 1.5 9.3 6.4 0.26 11.8 0.2 2.7 1 1 1 2 2 2 0 ABC transporter AAA_33 PF13671.6 EDN10965.1 - 8.9 6.5 11.6 1.3 9.2 0.1 3.1 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 EDN10966.1 - 3.6e-29 101.9 0.0 7.9e-29 100.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10966.1 - 1.7e-17 63.6 0.0 3e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDN10966.1 - 0.064 13.2 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AMP-binding PF00501.28 EDN10967.1 - 2.6e-82 276.7 0.0 3.7e-82 276.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EDN10967.1 - 1.9e-39 135.6 0.0 5.6e-15 55.0 0.0 5.1 4 1 1 5 5 5 4 Condensation domain PP-binding PF00550.25 EDN10967.1 - 6.3e-20 71.3 3.8 2.1e-10 40.8 0.4 2.9 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding PF00501.28 EDN10968.1 - 1.3e-55 188.7 0.0 2e-55 188.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EDN10968.1 - 9.1e-06 25.9 0.1 1.9e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 EDN10968.1 - 4.1e-05 22.4 0.1 6.1e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Condensation domain Ank_2 PF12796.7 EDN10969.1 - 5.7e-22 78.1 0.0 1.3e-11 44.9 0.0 3.5 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN10969.1 - 2.1e-20 72.5 0.1 2.1e-08 34.3 0.0 4.9 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN10969.1 - 3.1e-19 69.1 0.3 0.00024 21.6 0.2 5.9 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EDN10969.1 - 8.1e-19 67.2 0.2 0.0014 18.9 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Cyclin PF08613.11 EDN10969.1 - 3e-16 60.2 0.0 5.4e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin Ank_3 PF13606.6 EDN10969.1 - 4.8e-15 54.2 3.2 0.035 14.7 0.0 6.6 5 1 0 5 5 5 4 Ankyrin repeat DHHC PF01529.20 EDN10969.1 - 3.9e-05 23.8 2.3 3.9e-05 23.8 2.3 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase NFRKB_winged PF14465.6 EDN10970.1 - 0.37 11.0 3.0 5.1 7.4 1.3 3.2 3 0 0 3 3 3 0 NFRKB Winged Helix-like TSC22 PF01166.18 EDN10970.1 - 0.4 11.0 3.2 14 6.1 0.1 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family Nup54 PF13874.6 EDN10970.1 - 0.42 10.7 13.2 0.32 11.1 0.3 3.8 3 1 0 3 3 3 0 Nucleoporin complex subunit 54 Rotamase PF00639.21 EDN10970.1 - 0.67 11.0 4.0 27 5.8 0.8 3.1 2 0 0 2 2 2 0 PPIC-type PPIASE domain DUF1910 PF08928.10 EDN10970.1 - 0.84 9.6 6.3 8.4 6.4 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) HALZ PF02183.18 EDN10970.1 - 2 8.7 7.6 5.1 7.4 0.1 4.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper SlyX PF04102.12 EDN10970.1 - 3.4 8.4 6.6 16 6.2 0.3 4.1 3 1 1 4 4 4 0 SlyX Fib_alpha PF08702.10 EDN10970.1 - 7.4 6.8 17.6 0.81 9.9 6.2 3.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 EDN10970.1 - 9 6.8 6.8 52 4.3 0.1 4.3 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Na_Ca_ex PF01699.24 EDN10971.1 - 1.9e-19 70.1 27.0 1.6e-10 41.1 7.6 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Zip PF02535.22 EDN10971.1 - 0.013 14.7 0.3 0.027 13.7 0.2 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter DUF3185 PF11381.8 EDN10971.1 - 0.015 15.3 1.5 6 7.0 0.0 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3185) MscS_TM PF12794.7 EDN10971.1 - 0.036 12.9 0.1 0.036 12.9 0.1 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF2633 PF11119.8 EDN10971.1 - 0.67 9.9 2.1 2.1 8.3 2.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) DUF202 PF02656.15 EDN10971.1 - 0.87 10.1 10.3 29 5.2 0.7 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF202) DUF4131 PF13567.6 EDN10971.1 - 6.7 6.3 9.0 61 3.2 4.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Abhydrolase_1 PF00561.20 EDN10972.1 - 4.4e-14 52.7 0.0 1.1e-13 51.4 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDN10972.1 - 3.2e-12 47.5 0.0 3.7e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDN10972.1 - 3.9e-10 39.4 0.0 1.1e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 EDN10972.1 - 0.15 12.4 0.0 0.62 10.5 0.0 1.9 2 0 0 2 2 2 0 Epoxide hydrolase N terminus PALP PF00291.25 EDN10973.1 - 7.5e-66 222.5 0.1 9.8e-66 222.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EDN10973.1 - 9.1e-11 42.0 0.1 1.5e-08 34.9 0.0 2.9 3 0 0 3 3 3 1 CBS domain DUF1776 PF08643.10 EDN10973.1 - 0.2 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AA_kinase PF00696.28 EDN10974.1 - 1.5e-29 103.3 0.1 2.2e-29 102.8 0.1 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EDN10974.1 - 1.1e-16 60.5 0.1 2e-16 59.7 0.1 1.4 1 0 0 1 1 1 1 PUA domain Peptidase_M76 PF09768.9 EDN10975.1 - 3e-47 160.6 4.9 3.3e-47 160.4 4.9 1.0 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M13 PF01431.21 EDN10975.1 - 0.023 14.3 0.6 0.023 14.3 0.6 1.3 1 1 0 1 1 1 0 Peptidase family M13 Pkinase PF00069.25 EDN10976.1 - 1.9e-71 240.6 0.0 2.4e-71 240.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN10976.1 - 1.7e-43 148.8 0.0 2.2e-43 148.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDN10976.1 - 6.2e-08 32.3 0.0 1.6e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDN10976.1 - 0.00018 20.9 0.2 0.0003 20.2 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDN10976.1 - 0.0013 17.7 0.0 0.0013 17.7 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 EDN10976.1 - 0.016 14.8 0.0 0.05 13.2 0.0 1.7 1 1 1 2 2 2 0 RIO1 family FTA2 PF13095.6 EDN10976.1 - 0.037 13.6 0.1 0.096 12.3 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EDN10976.1 - 0.044 12.6 1.1 0.084 11.6 1.1 1.5 1 1 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EDN10976.1 - 0.056 13.0 0.0 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 EDN10976.1 - 0.063 13.2 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Macoilin PF09726.9 EDN10976.1 - 0.37 9.3 1.8 0.46 9.0 1.8 1.1 1 0 0 1 1 1 0 Macoilin family TIP41 PF04176.13 EDN10977.1 - 2.5e-12 46.6 0.0 3.4e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 TIP41-like family Ubiq_cyt_C_chap PF03981.12 EDN10978.1 - 1.3e-40 138.8 0.0 1.7e-40 138.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Peptidase_M1 PF01433.20 EDN10979.1 - 2.4e-46 158.0 0.4 3.4e-46 157.6 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDN10979.1 - 1.2e-28 100.6 0.6 1.7e-28 100.1 0.6 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Leuk-A4-hydro_C PF09127.11 EDN10979.1 - 1.9e-20 73.1 0.3 6.5e-20 71.3 0.1 2.0 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal GST_C PF00043.25 EDN10979.1 - 0.026 14.7 0.0 0.073 13.3 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Peptidase_M61 PF05299.12 EDN10979.1 - 0.081 13.3 2.3 1.8 9.0 2.3 2.6 1 1 0 1 1 1 0 M61 glycyl aminopeptidase SCAN PF02023.17 EDN10980.1 - 0.098 12.5 1.5 0.22 11.3 1.5 1.6 1 0 0 1 1 1 0 SCAN domain RVT_1 PF00078.27 EDN10981.1 - 1.8e-33 115.9 0.0 3e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN10981.1 - 3.7e-12 46.1 0.0 1.1e-11 44.6 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN10981.1 - 4.5e-12 46.4 0.0 1e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 RNase H ORF_12_N PF18042.1 EDN10981.1 - 0.052 14.0 0.8 0.21 12.0 0.5 2.2 2 0 0 2 2 2 0 ORF 12 gene product N-terminal BTB PF00651.31 EDN10983.1 - 4.4e-05 23.7 0.0 0.00019 21.6 0.0 2.0 1 1 0 1 1 1 1 BTB/POZ domain AhpC-TSA PF00578.21 EDN10984.1 - 4.1e-23 81.6 0.0 6.6e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDN10984.1 - 3.4e-15 56.0 0.0 5.3e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EDN10984.1 - 0.00041 20.4 0.0 0.00071 19.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF2183 PF09949.9 EDN10984.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) DUF3435 PF11917.8 EDN10985.1 - 3.4e-153 510.5 0.0 4.8e-153 510.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) UCMA PF17085.5 EDN10985.1 - 2 8.4 5.3 5.2 7.1 5.3 1.6 1 0 0 1 1 1 0 Unique cartilage matrix associated protein CAP_N PF01213.19 EDN10985.1 - 2 7.8 3.5 2.8 7.4 0.8 2.3 3 0 0 3 3 3 0 Adenylate cyclase associated (CAP) N terminal DUF1151 PF06625.11 EDN10985.1 - 6.3 6.8 8.4 5.3 7.0 4.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) RVT_1 PF00078.27 EDN10987.1 - 2.6e-39 135.0 0.0 4.9e-39 134.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN10987.1 - 1.2e-23 83.2 0.2 4.8e-23 81.2 0.2 2.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN10987.1 - 2.5e-11 44.0 0.0 6.2e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN10987.1 - 6.9e-07 29.1 0.5 1.6e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 Reverse transcriptase-like Exo_endo_phos PF03372.23 EDN10987.1 - 3.4e-05 23.5 0.2 9.3e-05 22.0 0.2 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN10987.1 - 0.0063 16.6 4.0 0.019 15.0 4.0 1.9 1 0 0 1 1 1 1 Zinc knuckle PuR_N PF09182.10 EDN10987.1 - 0.021 14.7 0.1 0.087 12.8 0.1 2.0 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal RVT_2 PF07727.14 EDN10988.1 - 7.4e-37 127.3 0.0 3.5e-36 125.1 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN10988.1 - 4.3e-12 46.3 0.0 1.2e-11 44.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN10988.1 - 0.0026 17.6 0.0 0.0061 16.4 0.0 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain DcrB PF08786.11 EDN10989.1 - 0.054 13.6 0.0 0.092 12.8 0.0 1.3 1 0 0 1 1 1 0 DcrB AAA PF00004.29 EDN10990.1 - 1.2e-17 64.5 0.0 2.6e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN10990.1 - 0.00055 20.4 0.0 0.0026 18.2 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EDN10990.1 - 0.0019 18.2 0.0 0.0047 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDN10990.1 - 0.011 16.0 0.1 0.19 12.0 0.0 2.6 1 1 1 2 2 2 0 AAA domain RuvB_N PF05496.12 EDN10990.1 - 0.028 14.1 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDN10990.1 - 0.079 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EDN10990.1 - 0.14 12.5 0.0 0.49 10.8 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Stork_head PF10264.9 EDN10993.1 - 0.0048 17.0 0.1 0.062 13.5 0.0 2.6 3 0 0 3 3 3 1 Winged helix Storkhead-box1 domain HEAT_2 PF13646.6 EDN10994.1 - 1.2e-87 288.4 37.4 4.4e-17 62.3 2.5 4.7 1 1 6 7 7 7 7 HEAT repeats HEAT PF02985.22 EDN10994.1 - 9.5e-34 112.6 0.9 0.0019 18.3 0.0 8.8 9 0 0 9 9 8 7 HEAT repeat HEAT_EZ PF13513.6 EDN10994.1 - 1.4e-31 108.5 11.9 0.0042 17.5 0.1 8.5 8 1 1 9 9 8 8 HEAT-like repeat Arm PF00514.23 EDN10994.1 - 1.9e-23 81.7 3.3 0.028 14.5 0.0 9.0 5 2 4 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.16 EDN10994.1 - 1e-22 78.4 8.3 0.13 13.0 0.0 8.6 8 0 0 8 8 8 6 PBS lyase HEAT-like repeat Cnd1 PF12717.7 EDN10994.1 - 1.1e-15 58.1 2.9 0.0051 16.9 0.0 6.0 1 1 4 5 5 5 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDN10994.1 - 3.1e-14 52.5 0.7 0.00026 19.7 0.2 3.3 1 1 2 3 3 3 3 Adaptin N terminal region CLASP_N PF12348.8 EDN10994.1 - 4.9e-09 36.1 1.5 0.07 12.7 0.1 4.7 1 1 1 3 3 3 3 CLASP N terminal TPR_22 PF18833.1 EDN10994.1 - 1.9e-07 31.1 5.5 8.4 6.6 0.0 7.5 3 2 5 8 8 8 0 Tetratricopeptide repeat Aconitase_B_N PF11791.8 EDN10994.1 - 1.5e-05 25.1 9.3 1.4 9.0 0.1 5.9 1 1 3 6 6 6 1 Aconitate B N-terminal domain Vac14_Fab1_bd PF12755.7 EDN10994.1 - 1.8e-05 25.2 1.0 15 6.3 0.1 5.7 3 2 2 5 5 5 0 Vacuolar 14 Fab1-binding region BET PF17035.5 EDN10994.1 - 2.8e-05 24.2 6.8 73 3.6 0.0 7.5 8 0 0 8 8 8 0 Bromodomain extra-terminal - transcription regulation P22_AR_C PF10548.9 EDN10994.1 - 2.9e-05 24.2 0.0 1.7 8.9 0.0 5.4 6 0 0 6 6 5 1 P22AR C-terminal domain SwrA PF17423.2 EDN10994.1 - 8.3e-05 22.6 5.3 8.3 6.4 0.0 6.0 1 1 6 7 7 7 0 Swarming motility protein GhoS PF11080.8 EDN10994.1 - 9e-05 22.4 3.8 5.5 7.0 0.0 4.6 1 1 5 6 6 6 1 Endoribonuclease GhoS CTNNBL PF08216.11 EDN10994.1 - 0.0022 18.2 0.1 20 5.4 0.0 4.5 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear FAA_hydrolase_N PF09298.11 EDN10994.1 - 0.0027 17.9 6.0 7.2 6.8 0.3 4.5 1 1 3 4 4 4 0 Fumarylacetoacetase N-terminal EF-hand_8 PF13833.6 EDN10994.1 - 0.0033 17.3 0.2 61 3.6 0.0 5.7 6 0 0 6 6 6 0 EF-hand domain pair DUF1087 PF06465.13 EDN10994.1 - 0.0043 17.1 2.3 14 5.8 0.0 4.7 6 0 0 6 6 6 0 Domain of Unknown Function (DUF1087) DUF520 PF04461.13 EDN10994.1 - 0.014 15.6 6.8 6.3 6.9 0.4 3.8 1 1 2 4 4 4 0 Protein of unknown function (DUF520) UpxZ PF06603.11 EDN10994.1 - 0.022 15.0 1.9 25 5.2 0.1 3.6 2 1 1 3 3 3 0 UpxZ family of transcription anti-terminator antagonists DUF4439 PF14530.6 EDN10994.1 - 0.034 14.8 4.2 43 4.8 0.1 4.7 1 1 4 6 6 6 0 Domain of unknown function (DUF4439) KH_4 PF13083.6 EDN10994.1 - 0.041 13.7 2.5 1.8e+02 2.1 0.1 5.5 6 0 0 6 6 5 0 KH domain RasGEF_N_2 PF14663.6 EDN10994.1 - 0.046 14.1 5.4 4.7 7.7 0.4 4.6 2 2 2 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DAG1 PF05454.11 EDN10994.1 - 0.11 11.8 0.0 8 5.7 0.0 3.0 1 1 2 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) CHASE2 PF05226.11 EDN10994.1 - 0.67 9.6 3.8 21 4.7 3.8 2.4 1 1 0 1 1 1 0 CHASE2 domain V-ATPase_H_N PF03224.14 EDN10994.1 - 0.73 9.1 8.1 13 4.9 2.9 2.8 1 1 1 2 2 2 0 V-ATPase subunit H ISG65-75 PF11727.8 EDN10994.1 - 0.78 8.9 7.2 32 3.6 0.3 3.9 1 1 3 4 4 4 0 Invariant surface glycoprotein DUF5129 PF17173.4 EDN10994.1 - 3.7 6.6 9.8 8.7 5.4 2.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5129) PC_rep PF01851.22 EDN10994.1 - 3.8 8.1 12.5 52 4.5 0.1 6.0 6 0 0 6 6 5 0 Proteasome/cyclosome repeat bZIP_1 PF00170.21 EDN10994.1 - 5.6 7.1 11.4 39 4.4 0.1 5.1 3 3 2 5 5 5 0 bZIP transcription factor Merozoite_SPAM PF07133.11 EDN10994.1 - 7.2 6.6 9.4 8.5 6.3 0.6 4.2 2 2 1 4 4 4 0 Merozoite surface protein (SPAM) NACHT PF05729.12 EDN10995.1 - 5.2e-12 46.0 0.0 1.1e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 EDN10995.1 - 3.5e-06 26.4 0.0 6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EDN10995.1 - 0.00075 19.8 0.0 0.0018 18.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EDN10995.1 - 0.0042 17.0 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.6 EDN10995.1 - 0.0052 17.2 0.0 0.015 15.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDN10995.1 - 0.0058 17.2 0.0 0.016 15.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain TsaE PF02367.17 EDN10995.1 - 0.058 13.4 0.0 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 EDN10995.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EDN10995.1 - 0.061 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase PNP_UDP_1 PF01048.20 EDN10995.1 - 0.076 12.2 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphorylase superfamily AAA_14 PF13173.6 EDN10995.1 - 0.084 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EDN10995.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EDN10995.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_17 PF13207.6 EDN10995.1 - 0.14 12.6 0.0 0.55 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EDN10995.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RVT_1 PF00078.27 EDN10997.1 - 4.6e-30 104.8 0.1 1.7e-29 102.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN10997.1 - 7.5e-12 45.6 0.0 1.7e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN10997.1 - 2.8e-10 40.1 0.0 9e-10 38.4 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN10997.1 - 0.059 13.8 0.8 0.22 11.9 0.5 2.1 2 0 0 2 2 2 0 ORF 12 gene product N-terminal CI-B14_5a PF07347.12 EDN10998.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) DDHD PF02862.17 EDN10999.1 - 4.7e-32 112.0 0.1 1.1e-31 110.7 0.0 1.6 2 0 0 2 2 2 1 DDHD domain CH PF00307.31 EDN11000.1 - 9e-68 225.3 0.1 7.6e-19 67.9 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EDN11000.1 - 2.2e-05 24.8 1.4 0.00014 22.2 0.3 2.7 3 0 0 3 3 3 1 EF-hand domain pair CAMSAP_CH PF11971.8 EDN11000.1 - 0.001 18.9 0.0 0.3 10.9 0.0 3.3 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_6 PF13405.6 EDN11000.1 - 0.0046 16.8 2.3 0.15 12.1 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EDN11000.1 - 0.011 15.2 0.6 1.4 8.6 0.1 3.1 3 0 0 3 3 3 0 EF hand Mito_carr PF00153.27 EDN11001.1 - 3.3e-76 251.3 1.6 2.6e-25 88.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDN11001.1 - 6.6e-06 25.5 0.4 0.00086 18.5 0.0 3.3 2 1 2 4 4 4 1 Gammaproteobacterial serine protease Ribosomal_L18 PF17135.4 EDN11002.1 - 3.6e-92 306.9 2.8 4e-92 306.8 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EDN11002.1 - 8.1e-05 23.3 0.3 0.00038 21.1 0.3 2.1 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AAA_19 PF13245.6 EDN11002.1 - 0.14 12.4 0.2 0.18 12.1 0.2 1.2 1 0 0 1 1 1 0 AAA domain Aldedh PF00171.22 EDN11003.1 - 5.1e-11 41.7 0.8 1.3e-07 30.5 0.1 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family AA_permease PF00324.21 EDN11004.1 - 7.9e-05 21.4 0.4 0.00011 20.9 0.4 1.1 1 0 0 1 1 1 1 Amino acid permease Cu_amine_oxid PF01179.20 EDN11005.1 - 3.9e-157 523.4 0.0 4.9e-157 523.1 0.0 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EDN11005.1 - 0.032 14.6 0.0 0.061 13.7 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N3 domain DUF2917 PF11142.8 EDN11005.1 - 0.087 12.2 0.1 4 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2917) Nexin_C PF08628.12 EDN11006.1 - 0.0082 16.7 0.3 0.012 16.1 0.3 1.2 1 0 0 1 1 1 1 Sorting nexin C terminal YqzE PF14038.6 EDN11006.1 - 2.7 8.1 6.9 37 4.4 4.9 2.5 2 1 0 2 2 2 0 YqzE-like protein Pkinase_fungal PF17667.1 EDN11012.1 - 4.2e-26 91.7 0.1 5.3e-26 91.3 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN11012.1 - 0.034 13.5 0.0 0.043 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain RRM_1 PF00076.22 EDN11013.1 - 4.2e-15 55.3 0.0 4.6e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RVT_2 PF07727.14 EDN11014.1 - 9.4e-23 81.1 0.0 1.4e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN11014.1 - 1.5e-11 44.6 0.0 3.3e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN11014.1 - 6.3e-08 32.4 0.0 1.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 EDN11014.1 - 0.022 14.5 0.0 0.061 13.1 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain RVT_2 PF07727.14 EDN11015.1 - 3.8e-58 197.0 0.0 4.9e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PP_M1 PF03012.14 EDN11016.1 - 0.24 10.9 0.0 0.34 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein RVT_1 PF00078.27 EDN11017.1 - 7.5e-23 81.2 0.0 1.1e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) OrsD PF12013.8 EDN11021.1 - 4.2e-17 62.6 2.6 4.2e-17 62.6 2.6 2.3 3 1 1 4 4 4 1 Orsellinic acid/F9775 biosynthesis cluster protein D DUF4298 PF14131.6 EDN11021.1 - 0.021 14.7 3.4 0.7 9.9 0.2 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4298) Borrelia_P83 PF05262.11 EDN11021.1 - 2.6 6.5 10.0 5.1 5.5 2.4 2.1 2 0 0 2 2 2 0 Borrelia P83/100 protein RNA_pol_inhib PF16857.5 EDN11023.1 - 0.16 11.8 0.2 5.6 6.8 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase inhibitor Helicase_C PF00271.31 EDN11024.1 - 1.7e-12 47.7 0.0 4.6e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RT_RNaseH PF17917.1 EDN11026.1 - 1.9e-39 134.1 0.4 1.9e-39 134.1 0.4 2.4 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN11026.1 - 1.2e-34 118.3 0.0 3.8e-34 116.7 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN11026.1 - 5.3e-28 98.1 0.4 1.1e-27 97.0 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 EDN11026.1 - 3.3e-19 68.7 0.1 7.6e-19 67.6 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN11026.1 - 1.9e-14 53.8 0.0 5.9e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN11026.1 - 1e-12 47.8 0.2 2.8e-12 46.4 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN11026.1 - 5.7e-06 26.4 0.1 2.3e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger Tudor-knot PF11717.8 EDN11026.1 - 0.0052 16.6 0.2 0.044 13.7 0.0 2.5 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Asp_protease_2 PF13650.6 EDN11026.1 - 0.21 12.3 0.0 0.4 11.3 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease NDUFA12 PF05071.16 EDN11026.1 - 2.5 9.0 7.0 3.5 8.5 4.4 2.7 2 0 0 2 2 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 TSNAXIP1_N PF15739.5 EDN11026.1 - 3.2 8.2 10.5 0.82 10.1 0.5 3.1 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus GRIP PF01465.20 EDN11027.1 - 3.8e-17 61.9 0.1 7.9e-17 60.9 0.1 1.6 1 0 0 1 1 1 1 GRIP domain CALCOCO1 PF07888.11 EDN11027.1 - 0.00023 20.2 24.4 0.00023 20.2 24.4 4.7 2 2 3 5 5 5 2 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.12 EDN11027.1 - 0.00041 20.4 7.5 0.00041 20.4 7.5 10.3 4 2 7 12 12 11 4 TPR/MLP1/MLP2-like protein GAS PF13851.6 EDN11027.1 - 0.00087 18.7 13.1 0.00087 18.7 13.1 8.4 3 2 6 9 9 9 6 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EDN11027.1 - 0.0044 16.0 99.6 0.83 8.5 10.3 6.5 2 2 2 5 5 5 4 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EDN11027.1 - 0.0051 16.8 28.6 0.11 12.5 0.8 5.9 3 1 1 6 6 6 3 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4201 PF13870.6 EDN11027.1 - 0.0068 16.2 17.0 0.0068 16.2 17.0 8.2 3 1 4 8 8 8 2 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.9 EDN11027.1 - 0.0083 16.2 12.0 0.0083 16.2 12.0 7.3 3 2 4 7 7 7 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Snapin_Pallidin PF14712.6 EDN11027.1 - 0.055 13.9 0.4 0.055 13.9 0.4 8.1 5 4 3 8 8 8 0 Snapin/Pallidin FPP PF05911.11 EDN11027.1 - 0.078 11.2 96.5 0.13 10.4 16.9 5.0 1 1 4 5 5 5 0 Filament-like plant protein, long coiled-coil Fib_alpha PF08702.10 EDN11027.1 - 0.29 11.3 58.5 1.8 8.7 4.4 6.9 2 2 5 8 8 8 0 Fibrinogen alpha/beta chain family Filament PF00038.21 EDN11027.1 - 0.31 10.6 99.0 2.4 7.7 1.1 6.8 2 2 4 6 6 6 0 Intermediate filament protein AAA_13 PF13166.6 EDN11027.1 - 1.1 7.9 73.3 0.17 10.5 18.6 5.2 1 1 3 5 5 5 0 AAA domain HMMR_N PF15905.5 EDN11027.1 - 2.9 7.3 91.8 0.37 10.2 19.2 5.6 2 1 3 5 5 5 0 Hyaluronan mediated motility receptor N-terminal DUF2407_C PF13373.6 EDN11028.1 - 0.9 9.7 7.3 1.2 9.3 7.3 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain MRP-S26 PF14943.6 EDN11028.1 - 0.96 9.3 20.9 1.7 8.5 20.9 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF2229 PF09989.9 EDN11028.1 - 0.98 9.0 7.1 1.1 8.9 7.1 1.1 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) RNase_H PF00075.24 EDN11029.1 - 2.1e-12 47.4 0.0 6.5e-12 45.8 0.0 1.8 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN11029.1 - 0.064 13.1 0.4 0.32 10.8 0.1 2.4 2 1 0 2 2 2 0 Reverse transcriptase-like FlxA PF14282.6 EDN11030.1 - 0.032 14.2 6.8 0.13 12.2 5.2 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF3375 PF11855.8 EDN11030.1 - 0.035 13.1 8.0 0.044 12.7 5.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) FUSC PF04632.12 EDN11030.1 - 2.2 6.7 3.6 3 6.3 3.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family RT_RNaseH PF17917.1 EDN11031.1 - 9.7e-37 125.5 0.0 2e-36 124.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDN11031.1 - 3.2e-32 110.5 0.0 6.6e-32 109.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN11031.1 - 5e-20 71.3 1.8 1e-19 70.3 0.3 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EDN11031.1 - 0.0013 18.9 0.0 0.0023 18.1 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 EDN11031.1 - 0.071 13.3 0.0 0.36 11.0 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain RVP_2 PF08284.11 EDN11031.1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease TackOD1 PF18551.1 EDN11033.1 - 0.91 9.2 4.5 1.4 8.6 4.5 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 RT_RNaseH PF17917.1 EDN11034.1 - 8.3e-35 119.2 0.0 6.9e-34 116.3 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDN11034.1 - 4.4e-31 108.1 0.0 7.7e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDN11034.1 - 1.3e-23 83.0 0.3 1.8e-12 47.2 0.0 3.0 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDN11034.1 - 3.1e-19 68.8 0.2 7.9e-19 67.5 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDN11034.1 - 4.8e-15 55.8 0.0 1.8e-14 53.9 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 EDN11034.1 - 7e-14 51.5 1.5 2e-13 50.0 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 EDN11034.1 - 1.8e-05 24.9 0.1 4e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Mtf2_C PF14061.6 EDN11034.1 - 0.034 14.3 1.0 0.37 11.0 0.2 2.5 1 1 1 2 2 2 0 Polycomb-like MTF2 factor 2 Retrotran_gag_2 PF14223.6 EDN11034.1 - 0.36 10.5 1.6 0.89 9.2 1.6 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type EKLF_TAD1 PF16832.5 EDN11035.1 - 0.043 13.7 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 DDE_1 PF03184.19 EDN11036.1 - 5.8e-31 107.5 0.0 1.5e-30 106.2 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11036.1 - 7.5e-11 41.9 0.0 2.1e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN11036.1 - 3.4e-07 29.9 0.1 9.2e-07 28.5 0.1 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN11036.1 - 0.00035 20.3 0.1 0.016 15.0 0.0 2.5 2 0 0 2 2 2 1 DDE superfamily endonuclease NDC10_II PF16787.5 EDN11037.1 - 5.6e-39 134.0 0.0 3.5e-20 72.3 1.9 3.3 2 2 1 3 3 3 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDN11037.1 - 3.4e-17 62.5 0.3 1.4e-16 60.5 0.1 2.2 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes DUF3716 PF12511.8 EDN11037.1 - 0.058 13.4 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Dot_icm_IcmQ PF09475.10 EDN11037.1 - 0.14 11.6 0.7 0.53 9.7 0.2 2.0 2 0 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) DDE_1 PF03184.19 EDN11038.1 - 8.1e-23 81.0 0.0 1.8e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN11038.1 - 6.9e-05 22.6 0.0 0.00091 19.0 0.0 2.6 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11038.1 - 0.0016 18.5 0.0 0.0063 16.5 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN11038.1 - 0.028 14.2 0.5 0.028 14.2 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN11038.1 - 0.047 13.2 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) TFIIA PF03153.13 EDN11038.1 - 1.3 8.9 14.1 1.9 8.4 14.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 EDN11038.1 - 2.9 6.3 20.9 4.6 5.6 20.9 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Med17 PF10156.9 EDN11039.1 - 7.6e-102 341.4 1.0 1.1e-101 340.9 1.0 1.2 1 0 0 1 1 1 1 Subunit 17 of Mediator complex ISN1 PF06437.11 EDN11040.1 - 5.3e-183 608.6 0.0 6e-183 608.4 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Lyase_aromatic PF00221.19 EDN11040.1 - 0.074 11.7 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Aromatic amino acid lyase Ank_4 PF13637.6 EDN11041.1 - 5.4e-10 39.6 0.1 1.4e-06 28.7 0.0 3.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDN11041.1 - 3.2e-08 34.1 0.0 0.0093 16.5 0.0 3.2 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 EDN11041.1 - 2.4e-05 24.5 0.1 0.0064 16.9 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 EDN11041.1 - 3e-05 24.2 0.0 0.0028 17.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDN11041.1 - 7.8e-05 22.8 0.3 0.75 10.6 0.0 4.9 6 0 0 6 6 6 1 Ankyrin repeat DDE_1 PF03184.19 EDN11042.1 - 1.2e-33 116.2 0.0 2.1e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN11042.1 - 1.3e-05 24.9 0.0 0.00045 20.0 0.0 2.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11042.1 - 0.0087 16.1 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-CCHC_6 PF15288.6 EDN11042.1 - 0.14 12.0 0.4 1.6 8.6 0.1 2.5 2 0 0 2 2 2 0 Zinc knuckle HNH_2 PF13391.6 EDN11043.1 - 8.1e-16 57.9 0.0 1.8e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease DDE_3 PF13358.6 EDN11044.1 - 1.7e-30 105.7 0.0 4.3e-30 104.4 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 EDN11044.1 - 9.8e-07 28.3 0.0 3.4e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix rve PF00665.26 EDN11044.1 - 0.0003 21.0 0.0 0.0016 18.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain PAX PF00292.18 EDN11044.1 - 0.043 13.7 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 'Paired box' domain cNMP_binding PF00027.29 EDN11045.1 - 3.6e-28 97.5 0.2 5.5e-18 64.8 0.0 5.9 6 0 0 6 6 6 3 Cyclic nucleotide-binding domain Patatin PF01734.22 EDN11045.1 - 3.8e-18 66.4 9.1 3.4e-17 63.3 6.8 2.9 2 1 0 2 2 2 1 Patatin-like phospholipase CAML PF14963.6 EDN11045.1 - 0.23 11.5 0.9 4.7 7.3 0.1 2.5 3 0 0 3 3 3 0 Calcium signal-modulating cyclophilin ligand zinc_ribbon_10 PF10058.9 EDN11046.1 - 8.7e-21 73.4 0.1 1.4e-20 72.7 0.1 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein HD PF01966.22 EDN11047.1 - 1.8e-05 25.0 0.0 4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 HD domain DUF5070 PF16802.5 EDN11047.1 - 0.027 14.5 0.0 0.073 13.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5070) ANAPC4_WD40 PF12894.7 EDN11049.1 - 0.0015 18.8 0.0 4.5 7.6 0.0 5.0 4 2 3 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDN11049.1 - 0.0015 19.3 3.8 1.2 10.2 0.0 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat Synaptobrevin PF00957.21 EDN11050.1 - 7.5e-14 51.3 0.5 1.7e-13 50.2 0.5 1.5 1 0 0 1 1 1 1 Synaptobrevin Sec63 PF02889.16 EDN11051.1 - 4.7e-126 419.2 0.0 2.4e-78 262.9 0.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EDN11051.1 - 5e-52 176.2 0.4 1.7e-26 93.1 0.7 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EDN11051.1 - 8.2e-23 81.3 0.0 8.9e-11 42.1 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDN11051.1 - 1e-15 58.1 0.0 1.4e-07 31.8 0.0 4.4 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDN11051.1 - 1.1e-07 32.2 0.1 0.0055 17.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDN11051.1 - 8.3e-07 28.9 0.1 0.013 15.2 0.2 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EDN11051.1 - 4.1e-05 23.9 1.0 0.0078 16.6 0.8 2.6 2 0 0 2 2 2 1 AAA domain Helicase_PWI PF18149.1 EDN11051.1 - 0.0075 16.4 0.2 0.02 15.1 0.2 1.7 1 0 0 1 1 1 1 N-terminal helicase PWI domain T2SSE PF00437.20 EDN11051.1 - 0.013 14.6 0.0 1.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EDN11051.1 - 0.07 12.9 0.1 12 5.6 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein TniB PF05621.11 EDN11051.1 - 0.17 11.3 0.6 19 4.6 0.1 3.3 3 0 0 3 3 3 0 Bacterial TniB protein SUIM_assoc PF16619.5 EDN11052.1 - 0.09 12.9 10.1 0.033 14.2 5.7 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Profilin PF00235.19 EDN11053.1 - 1.5e-29 102.9 0.0 1.7e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 Profilin Got1 PF04178.12 EDN11054.1 - 1.4e-14 54.4 14.8 2.3e-14 53.8 14.0 1.6 1 1 1 2 2 2 1 Got1/Sft2-like family SdpI PF13630.6 EDN11054.1 - 4.3 7.5 8.7 8.1 6.7 0.7 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family YL1_C PF08265.11 EDN11055.1 - 1.4e-16 60.0 0.4 2.2e-16 59.3 0.4 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain TonB_N PF16031.5 EDN11055.1 - 0.079 13.5 1.2 0.18 12.4 1.2 1.5 1 0 0 1 1 1 0 TonB polyproline region Actin PF00022.19 EDN11056.1 - 7.1e-50 169.8 0.0 7.7e-49 166.4 0.0 2.3 1 1 0 1 1 1 1 Actin DASH_Dad4 PF08650.10 EDN11056.1 - 1.9e-11 43.8 3.7 5.3e-11 42.3 3.7 1.8 1 0 0 1 1 1 1 DASH complex subunit Dad4 bZIP_1 PF00170.21 EDN11057.1 - 7.9e-08 32.3 6.9 2.2e-07 30.9 6.9 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDN11057.1 - 0.29 11.2 9.9 5 7.3 9.2 2.9 2 1 0 2 2 2 0 Basic region leucine zipper BCAS2 PF05700.11 EDN11057.1 - 0.61 9.7 6.4 5.2 6.7 1.5 2.2 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Anoctamin PF04547.12 EDN11058.1 - 5.3e-118 394.7 4.4 6.4e-118 394.4 4.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Acetyltransf_1 PF00583.25 EDN11059.1 - 1.7e-13 50.9 0.0 2.4e-13 50.4 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDN11059.1 - 1.1e-05 25.7 0.0 1.8e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDN11059.1 - 2.4e-05 24.2 0.0 3.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EDN11059.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDN11059.1 - 0.035 14.8 0.0 0.055 14.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_tranf_2_3 PF13641.6 EDN11061.1 - 1.1e-31 110.5 0.0 2.4e-31 109.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDN11061.1 - 2.8e-08 33.4 0.0 6e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDN11061.1 - 4.3e-07 29.9 0.0 9.8e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 EST1_DNA_bind PF10373.9 EDN11061.1 - 0.002 17.6 0.1 0.0038 16.8 0.1 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain NINJA_B PF16136.5 EDN11061.1 - 0.044 14.1 0.2 0.14 12.5 0.1 1.8 2 0 0 2 2 2 0 Putative nuclear localisation signal Methyltransf_23 PF13489.6 EDN11062.1 - 6.6e-16 58.6 0.0 1.2e-15 57.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN11062.1 - 3.6e-06 27.6 0.0 9.8e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11062.1 - 0.00034 20.5 0.1 0.016 15.0 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Merozoite_SPAM PF07133.11 EDN11062.1 - 0.005 16.9 37.5 0.0073 16.3 37.5 1.2 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) Methyltransf_11 PF08241.12 EDN11062.1 - 0.021 15.5 0.0 0.041 14.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Nop14 PF04147.12 EDN11062.1 - 0.022 13.0 28.9 0.027 12.7 28.9 1.1 1 0 0 1 1 1 0 Nop14-like family Methyltransf_12 PF08242.12 EDN11062.1 - 0.025 15.3 0.5 0.2 12.4 0.0 2.6 2 1 0 2 2 1 0 Methyltransferase domain SDA1 PF05285.12 EDN11062.1 - 0.026 14.0 26.7 0.038 13.4 26.7 1.3 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EDN11062.1 - 0.084 12.2 25.6 0.16 11.2 25.7 1.4 2 0 0 2 2 2 0 BUD22 CDC45 PF02724.14 EDN11062.1 - 0.093 11.0 22.1 0.12 10.6 22.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF5523 PF17661.1 EDN11062.1 - 0.098 12.3 19.4 0.14 11.8 19.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Mpp10 PF04006.12 EDN11062.1 - 0.27 9.6 28.0 0.39 9.1 28.0 1.2 1 0 0 1 1 1 0 Mpp10 protein Tim54 PF11711.8 EDN11062.1 - 0.6 8.8 12.5 0.85 8.3 12.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 EDN11062.1 - 1.4 7.7 7.3 1.7 7.3 7.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 EDN11062.1 - 2.3 8.5 12.8 3.8 7.8 12.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 EDN11062.1 - 2.5 8.5 9.1 4 7.8 9.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4637 PF15470.6 EDN11062.1 - 3.7 7.3 26.3 6.5 6.5 26.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Presenilin PF01080.17 EDN11062.1 - 4.4 6.0 8.6 5.5 5.6 8.6 1.1 1 0 0 1 1 1 0 Presenilin LAP1C PF05609.12 EDN11062.1 - 4.6 6.2 12.2 6.1 5.8 12.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Raftlin PF15250.6 EDN11062.1 - 5.3 5.7 7.4 6.7 5.3 7.4 1.1 1 0 0 1 1 1 0 Raftlin DUF2151 PF10221.9 EDN11062.1 - 6.9 5.1 9.3 9 4.8 9.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator RPN2_C PF18004.1 EDN11062.1 - 8.2 6.3 15.6 14 5.6 15.6 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RR_TM4-6 PF06459.12 EDN11062.1 - 8.4 6.1 15.7 13 5.5 15.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sporozoite_P67 PF05642.11 EDN11062.1 - 8.9 4.3 16.5 14 3.6 16.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AAA PF00004.29 EDN11063.1 - 3.3e-18 66.4 0.0 6.8e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EDN11063.1 - 4.5e-09 36.6 0.7 2.5e-08 34.1 0.3 2.3 1 1 1 2 2 2 1 BCS1 N terminal RuvB_N PF05496.12 EDN11063.1 - 0.0012 18.7 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDN11063.1 - 0.0029 16.9 0.0 0.0048 16.1 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EDN11063.1 - 0.0051 17.4 0.0 0.012 16.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDN11063.1 - 0.0053 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDN11063.1 - 0.017 15.5 0.0 0.042 14.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EDN11063.1 - 0.046 14.0 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN11063.1 - 0.057 13.6 0.1 0.2 11.8 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDN11063.1 - 0.078 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDN11063.1 - 0.084 12.6 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 EDN11063.1 - 0.13 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Antimicrobial13 PF08108.11 EDN11065.1 - 0.24 11.5 1.4 0.5 10.5 1.4 1.5 1 0 0 1 1 1 0 Halocidin family Helo_like_N PF17111.5 EDN11068.1 - 2.9e-08 33.3 0.5 2.9e-08 33.3 0.5 3.0 3 0 0 3 3 3 1 Fungal N-terminal domain of STAND proteins Glutaredoxin2_C PF04399.13 EDN11068.1 - 0.001 18.9 3.6 0.059 13.2 0.4 2.8 3 0 0 3 3 3 2 Glutaredoxin 2, C terminal domain TSC22 PF01166.18 EDN11068.1 - 0.0017 18.6 5.9 0.011 16.0 0.3 3.8 4 0 0 4 4 4 1 TSC-22/dip/bun family Myc-LZ PF02344.15 EDN11068.1 - 0.077 13.1 3.6 0.24 11.5 1.8 2.7 2 0 0 2 2 2 0 Myc leucine zipper domain Takusan PF04822.13 EDN11068.1 - 0.095 12.6 5.1 1.9 8.4 0.6 3.1 2 1 0 2 2 2 0 Takusan Herpes_BLRF2 PF05812.12 EDN11068.1 - 0.095 12.8 1.0 0.35 11.0 0.0 2.3 2 1 0 2 2 2 0 Herpesvirus BLRF2 protein YabA PF06156.13 EDN11068.1 - 0.28 11.8 5.8 15 6.3 0.1 2.5 2 0 0 2 2 2 0 Initiation control protein YabA Rho_Binding PF08912.11 EDN11068.1 - 1.8 9.4 7.8 2.3 9.1 0.1 2.8 2 1 1 3 3 3 0 Rho Binding Nnf1 PF03980.14 EDN11068.1 - 3.2 8.2 11.0 0.26 11.7 2.2 2.7 2 0 0 2 2 2 0 Nnf1 Phage_Mu_Gam PF07352.12 EDN11068.1 - 4.9 7.0 8.7 0.15 12.0 1.5 2.1 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein ZapB PF06005.12 EDN11068.1 - 7.4 7.1 15.7 1.6 9.2 0.5 3.4 3 0 0 3 3 3 0 Cell division protein ZapB F-box-like PF12937.7 EDN11070.1 - 1.3e-05 25.0 0.0 3.6e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN11070.1 - 0.0012 18.7 0.1 0.0048 16.7 0.0 2.1 2 0 0 2 2 2 1 F-box domain RTC4 PF14474.6 EDN11071.1 - 1.2e-26 93.2 0.1 2.2e-26 92.4 0.1 1.4 1 0 0 1 1 1 1 RTC4-like domain Myb_DNA-bind_6 PF13921.6 EDN11071.1 - 0.00028 21.1 2.8 0.00028 21.1 2.8 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDN11071.1 - 0.0045 17.1 1.1 0.01 16.0 1.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EDN11071.1 - 0.093 12.9 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 MHC_I PF00129.18 EDN11073.1 - 0.09 12.3 0.0 0.11 12.1 0.0 1.0 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 AA_permease_2 PF13520.6 EDN11074.1 - 3.9e-38 131.4 24.3 5.7e-38 130.8 24.3 1.2 1 0 0 1 1 1 1 Amino acid permease DDE_3 PF13358.6 EDN11075.1 - 1.7e-06 27.8 0.9 1.9e-06 27.7 0.9 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Brr6_like_C_C PF10104.9 EDN11077.1 - 1.4e-40 138.2 0.2 2.8e-40 137.2 0.0 1.6 2 0 0 2 2 2 1 Di-sulfide bridge nucleocytoplasmic transport domain GtrA PF04138.14 EDN11077.1 - 0.026 14.7 0.4 0.044 14.0 0.4 1.3 1 0 0 1 1 1 0 GtrA-like protein Fungal_trans_2 PF11951.8 EDN11078.1 - 4.8e-06 25.6 0.4 3.9e-05 22.6 0.4 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN11078.1 - 1.8e-05 24.8 12.4 1.8e-05 24.8 12.4 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TMEM108 PF15759.5 EDN11078.1 - 0.035 13.1 3.1 0.059 12.4 3.1 1.3 1 0 0 1 1 1 0 TMEM108 family Bud13 PF09736.9 EDN11082.1 - 1.8e-44 151.6 3.9 1.8e-44 151.6 3.9 2.9 3 1 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Pkinase PF00069.25 EDN11083.1 - 7.8e-39 133.6 0.0 5.5e-22 78.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN11083.1 - 8.6e-14 51.4 0.2 2e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDN11083.1 - 0.053 12.3 0.0 0.071 11.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase YbgS PF13985.6 EDN11083.1 - 0.33 11.2 0.1 0.33 11.2 0.1 1.9 2 0 0 2 2 2 0 YbgS-like protein Metallophos PF00149.28 EDN11085.1 - 1.8e-11 45.0 0.4 9.5e-11 42.6 0.4 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDN11085.1 - 0.0046 17.2 6.2 0.015 15.5 1.7 2.4 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain FMN_dh PF01070.18 EDN11086.1 - 1.1e-121 406.1 0.0 1.5e-121 405.7 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDN11086.1 - 6.1e-23 80.8 0.0 1.2e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDN11086.1 - 2.9e-07 30.0 0.0 4.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EDN11086.1 - 0.00071 18.7 0.1 0.002 17.2 0.0 1.8 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EDN11086.1 - 0.0021 17.5 0.1 0.0044 16.5 0.1 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase Ras PF00071.22 EDN11087.1 - 1.7e-38 131.7 0.0 1.9e-36 125.1 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EDN11087.1 - 2.1e-31 108.6 0.0 2.9e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN11087.1 - 3.1e-11 43.0 0.0 4.9e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDN11087.1 - 0.0001 22.4 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EDN11087.1 - 0.00084 19.8 0.0 0.0011 19.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 EDN11087.1 - 0.0017 17.7 0.0 0.0021 17.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDN11087.1 - 0.0047 16.4 0.0 0.0058 16.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EDN11087.1 - 0.013 15.7 0.1 0.029 14.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EDN11087.1 - 0.027 14.2 0.0 0.33 10.7 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EDN11087.1 - 0.047 13.2 0.1 0.07 12.6 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EDN11087.1 - 0.06 13.2 0.0 0.15 12.0 0.1 1.6 2 0 0 2 2 1 0 RsgA GTPase AAA_14 PF13173.6 EDN11087.1 - 0.088 12.8 0.0 0.16 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDN11087.1 - 0.098 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDN11087.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 EDN11087.1 - 0.14 12.2 0.1 0.23 11.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EDN11087.1 - 0.15 12.3 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 EDN11089.1 - 4.4e-06 26.9 14.7 0.11 13.0 1.2 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDN11089.1 - 4.4e-05 24.0 10.3 0.4 11.7 0.9 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EDN11089.1 - 0.0029 17.8 0.1 0.0029 17.8 0.1 1.5 2 0 0 2 2 2 1 Aberrant zinc-finger FOXP-CC PF16159.5 EDN11089.1 - 0.0078 16.8 3.9 0.73 10.5 1.6 3.2 1 1 2 3 3 3 1 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 EDN11089.1 - 4.4 7.9 13.7 0.47 11.0 1.3 3.5 3 0 0 3 3 3 0 Zinc-finger double domain Zn_clus PF00172.18 EDN11090.1 - 2.5e-08 33.9 9.2 6.6e-08 32.6 9.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cullin PF00888.22 EDN11092.1 - 0.042 12.5 0.1 0.048 12.3 0.1 1.1 1 0 0 1 1 1 0 Cullin family Pkinase_fungal PF17667.1 EDN11093.1 - 5.8e-126 420.6 0.0 7.1e-126 420.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Caskin-Pro-rich PF16907.5 EDN11093.1 - 0.044 14.3 4.7 5 7.7 0.1 2.5 2 0 0 2 2 2 0 Proline rich region of Caskin proteins DUF3446 PF11928.8 EDN11093.1 - 0.23 11.8 3.2 5.1 7.5 0.0 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain Interferon PF00143.19 EDN11094.1 - 0.0057 16.8 1.9 0.0092 16.2 1.9 1.3 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF4200 PF13863.6 EDN11094.1 - 0.0078 16.6 5.9 0.0078 16.6 5.9 1.6 2 0 0 2 2 1 1 Domain of unknown function (DUF4200) zf-C3HC4_3 PF13920.6 EDN11094.1 - 0.0078 16.1 6.0 0.014 15.2 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Cor1 PF04803.12 EDN11094.1 - 0.01 16.0 2.7 0.019 15.2 2.7 1.3 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region GAS PF13851.6 EDN11094.1 - 0.013 14.9 4.1 0.022 14.1 4.1 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HAUS-augmin3 PF14932.6 EDN11094.1 - 0.013 15.1 2.4 0.02 14.5 2.4 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 SOCS_box PF07525.16 EDN11094.1 - 0.028 14.8 0.1 0.072 13.5 0.1 1.7 1 0 0 1 1 1 0 SOCS box Metal_resist PF13801.6 EDN11094.1 - 0.082 13.1 2.9 0.83 9.8 0.5 2.2 2 0 0 2 2 2 0 Heavy-metal resistance Macoilin PF09726.9 EDN11094.1 - 0.14 10.7 2.4 0.2 10.2 2.4 1.2 1 0 0 1 1 1 0 Macoilin family FlaC_arch PF05377.11 EDN11094.1 - 0.19 12.2 4.5 3.1 8.3 0.9 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EDN11094.1 - 0.25 11.4 2.8 0.36 10.9 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) zf-RING_5 PF14634.6 EDN11094.1 - 0.31 11.0 7.8 0.66 10.0 7.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain DUF2570 PF10828.8 EDN11094.1 - 1.6 8.5 6.0 0.26 11.1 2.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) BRE1 PF08647.11 EDN11094.1 - 1.8 8.7 9.7 0.23 11.6 5.5 1.6 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF5446 PF17522.2 EDN11094.1 - 2.2 8.5 7.9 3.4 7.9 4.8 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5446) Seryl_tRNA_N PF02403.22 EDN11094.1 - 2.4 8.4 7.6 0.75 10.0 4.6 1.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMF_TATA_bd PF12325.8 EDN11094.1 - 3.1 8.0 10.8 5.1 7.4 7.8 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Pkinase_fungal PF17667.1 EDN11095.1 - 7.4e-66 222.6 0.0 2.5e-61 207.7 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 EDN11095.1 - 4.8e-13 49.1 0.7 8.6e-07 28.6 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Kdo PF06293.14 EDN11095.1 - 2.4e-07 30.3 0.0 3e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN11095.1 - 1.4e-06 28.4 0.3 0.018 15.0 0.1 2.9 2 1 0 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EDN11095.1 - 6.1e-05 22.7 0.0 0.21 11.2 0.0 2.3 2 0 0 2 2 2 2 RIO1 family Pkinase_Tyr PF07714.17 EDN11095.1 - 0.0012 18.2 0.5 0.034 13.4 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase HSDR_N_2 PF13588.6 EDN11095.1 - 0.013 15.5 0.0 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF4470 PF14737.6 EDN11097.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4470) RNase_H PF00075.24 EDN11098.1 - 2e-10 41.0 0.2 3.3e-07 30.6 0.1 2.3 2 0 0 2 2 2 2 RNase H PFK PF00365.20 EDN11099.1 - 4.3e-192 636.6 0.1 3.1e-105 351.6 0.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 EDN11099.1 - 0.11 12.1 0.1 0.34 10.5 0.1 1.8 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Glyco_hydro_76 PF03663.14 EDN11100.1 - 4.4e-149 497.0 8.0 5.2e-149 496.7 8.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EDN11100.1 - 3.4e-06 26.4 8.4 0.0021 17.2 0.1 3.1 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 MARVEL PF01284.23 EDN11101.1 - 4e-12 46.4 11.4 4.9e-12 46.1 11.4 1.1 1 0 0 1 1 1 1 Membrane-associating domain Jagunal PF07086.12 EDN11101.1 - 0.0084 16.2 0.5 0.012 15.7 0.3 1.4 1 1 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis DUF2964 PF11177.8 EDN11101.1 - 0.43 10.8 4.0 3.3 8.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2964) YebO PF13974.6 EDN11102.1 - 0.18 11.9 3.2 0.23 11.6 3.2 1.2 1 0 0 1 1 1 0 YebO-like protein HTH_8 PF02954.19 EDN11103.1 - 0.01 15.6 0.1 0.22 11.4 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_psq PF05225.16 EDN11103.1 - 0.062 13.1 0.0 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 EDN11103.1 - 0.1 12.6 0.1 0.41 10.7 0.0 2.2 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain Pkinase PF00069.25 EDN11104.1 - 4e-05 23.1 0.0 6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain NmrA PF05368.13 EDN11105.1 - 4.2e-61 206.5 0.0 5.4e-61 206.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN11105.1 - 3.5e-19 69.4 0.0 5.1e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EDN11105.1 - 0.00038 19.6 0.0 0.00055 19.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EDN11105.1 - 0.0089 16.3 0.0 0.024 14.9 0.0 1.8 2 1 1 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EDN11105.1 - 0.062 12.8 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family MFS_1 PF07690.16 EDN11106.1 - 1.4e-28 99.9 57.4 1.4e-28 99.9 57.4 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN11106.1 - 2e-11 43.4 6.3 2e-11 43.4 6.3 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EDN11106.1 - 0.9 7.7 18.9 0.018 13.3 4.4 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2070 PF09843.9 EDN11106.1 - 5.6 5.1 13.6 9.2 4.4 13.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Fungal_trans PF04082.18 EDN11107.1 - 3.8e-05 22.9 0.0 0.0002 20.5 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN11107.1 - 0.0061 16.7 10.0 0.0061 16.7 10.0 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EDN11108.1 - 6.4e-24 84.9 0.0 5.5e-23 81.8 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDN11108.1 - 1.4e-05 24.9 0.0 0.0028 17.3 0.4 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDN11108.1 - 0.0001 22.8 0.4 0.027 15.0 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDN11108.1 - 0.00013 21.3 0.1 0.0024 17.2 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN11108.1 - 0.00065 19.9 0.4 0.0015 18.8 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EDN11108.1 - 0.0035 16.5 0.0 0.0053 15.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EDN11108.1 - 0.0054 15.8 0.0 1.7 7.6 0.1 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein SE PF08491.10 EDN11108.1 - 0.0059 15.7 0.0 0.065 12.3 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase HET PF06985.11 EDN11110.1 - 4.4e-33 114.7 0.1 7.3e-33 114.0 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF2075 PF09848.9 EDN11110.1 - 0.0092 15.3 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Sterol_MT_C PF08498.10 EDN11111.1 - 2.3e-29 101.5 0.2 3.8e-29 100.8 0.2 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EDN11111.1 - 5.8e-18 65.3 0.0 1.1e-17 64.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN11111.1 - 4.7e-17 62.5 0.0 9.7e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11111.1 - 4e-13 49.4 0.0 6e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDN11111.1 - 1.6e-10 40.7 0.0 2.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDN11111.1 - 4.3e-09 37.0 0.0 1.2e-08 35.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN11111.1 - 2.8e-08 33.4 0.0 4.3e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EDN11111.1 - 1.3e-07 31.6 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EDN11111.1 - 0.0055 16.3 0.0 0.008 15.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_29 PF03141.16 EDN11111.1 - 0.0086 14.7 0.0 0.012 14.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PrmA PF06325.13 EDN11111.1 - 0.022 14.1 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDN11111.1 - 0.079 12.5 0.0 0.27 10.8 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EDN11111.1 - 0.13 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EDN11111.1 - 0.19 10.8 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RRM_1 PF00076.22 EDN11112.1 - 9e-09 35.0 0.0 3.2e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDN11112.1 - 0.00087 19.2 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EDN11112.1 - 0.063 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Complex1_LYR PF05347.15 EDN11113.1 - 0.00011 22.2 0.1 0.00027 20.9 0.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Arm-DNA-bind_3 PF13356.6 EDN11113.1 - 0.098 13.0 2.6 0.2 12.0 0.5 2.4 2 1 1 3 3 3 0 Arm DNA-binding domain RAC_head PF16717.5 EDN11114.1 - 2.6e-30 105.3 4.1 2.6e-30 105.3 4.1 3.1 2 1 0 2 2 2 1 Ribosome-associated complex head domain DnaJ PF00226.31 EDN11114.1 - 1.2e-18 67.0 0.7 5.4e-18 64.9 0.7 2.3 1 0 0 1 1 1 1 DnaJ domain CemA PF03040.14 EDN11114.1 - 3.9 7.3 5.7 8.1 6.3 5.7 1.5 1 0 0 1 1 1 0 CemA family TMEM119 PF15724.5 EDN11114.1 - 5.2 7.0 8.4 12 5.9 8.4 1.6 1 0 0 1 1 1 0 TMEM119 family Sulfatase PF00884.23 EDN11115.1 - 4.5e-57 193.8 0.1 6.1e-57 193.3 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 EDN11115.1 - 9.3e-25 86.2 0.1 2.1e-23 81.9 0.0 2.4 1 1 1 2 2 2 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EDN11115.1 - 2.1e-09 37.5 0.0 1.6e-08 34.6 0.0 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EDN11115.1 - 0.026 15.3 0.2 0.078 13.7 0.1 1.9 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF229 PF02995.17 EDN11115.1 - 0.073 11.7 0.0 0.089 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 EDN11115.1 - 0.079 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily Polysacc_synt_4 PF04669.13 EDN11116.1 - 0.039 13.5 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis PHD20L1_u1 PF16660.5 EDN11116.1 - 0.092 13.5 1.3 1 10.2 0.1 2.4 1 1 1 2 2 2 0 PHD finger protein 20-like protein 1 Amidohydro_1 PF01979.20 EDN11117.1 - 2.1e-61 208.2 0.0 8.3e-61 206.2 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase family FAD_binding_3 PF01494.19 EDN11117.1 - 5.7e-13 48.8 0.0 5.5e-11 42.3 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EDN11117.1 - 3.4e-06 27.2 0.1 1.3e-05 25.3 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amidohydro_3 PF07969.11 EDN11117.1 - 7.5e-05 22.4 1.4 0.044 13.3 0.2 2.6 2 1 0 2 2 2 2 Amidohydrolase family DAO PF01266.24 EDN11117.1 - 0.00034 20.3 0.0 0.00065 19.4 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EDN11117.1 - 0.00069 19.0 0.0 0.88 8.8 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EDN11117.1 - 0.0014 17.9 0.1 0.0031 16.8 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDN11117.1 - 0.0036 17.8 0.1 0.013 16.0 0.1 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDN11117.1 - 0.0045 16.1 0.1 0.007 15.5 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EDN11117.1 - 0.0054 15.9 0.2 0.0083 15.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EDN11117.1 - 0.0078 15.5 0.3 0.033 13.4 0.3 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDN11117.1 - 0.091 11.4 0.1 0.16 10.6 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EDN11117.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase ApbA PF02558.16 EDN11117.1 - 0.19 11.4 0.6 3 7.5 0.3 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GDC-P PF02347.16 EDN11118.1 - 3e-175 583.2 0.0 3.6e-163 543.4 0.0 2.4 2 0 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 EDN11118.1 - 1.3e-05 24.6 0.2 3.2e-05 23.3 0.2 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase Pox_A_type_inc PF04508.12 EDN11118.1 - 0.15 12.0 0.0 0.46 10.4 0.0 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat NTP_transf_9 PF04248.12 EDN11119.1 - 1e-26 92.6 0.2 1.2e-26 92.4 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) DUF917 PF06032.12 EDN11120.1 - 1.7e-109 365.9 0.4 3.5e-108 361.5 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EDN11120.1 - 1.4e-30 106.6 6.9 1.2e-26 93.6 0.8 3.4 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDN11120.1 - 1.1e-24 87.1 4.5 5.8e-22 78.3 0.2 3.4 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EDN11120.1 - 7.1e-05 21.6 2.7 0.22 10.1 0.2 3.2 3 0 0 3 3 3 2 MutL protein BcrAD_BadFG PF01869.20 EDN11120.1 - 0.0015 18.1 1.5 0.0062 16.1 0.1 2.6 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.11 EDN11120.1 - 0.033 13.4 0.8 2.5 7.3 0.1 2.7 3 0 0 3 3 3 0 StbA protein ACP_syn_III PF08545.10 EDN11120.1 - 0.32 10.9 2.4 0.77 9.7 0.0 2.7 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FtsA PF14450.6 EDN11120.1 - 3.8 8.0 8.7 54 4.3 0.3 3.8 2 2 0 2 2 2 0 Cell division protein FtsA Pyridox_ox_2 PF12900.7 EDN11121.1 - 5.9e-24 84.7 0.0 5.9e-23 81.4 0.0 2.2 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridoxal_deC PF00282.19 EDN11123.1 - 6.8e-97 324.5 0.0 8.2e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EDN11123.1 - 0.0016 17.8 0.0 0.0051 16.1 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase MBOAT_2 PF13813.6 EDN11124.1 - 1.9e-14 53.6 7.6 7.6e-09 35.7 0.5 2.8 3 0 0 3 3 3 2 Membrane bound O-acyl transferase family Polysacc_synt_3 PF13440.6 EDN11124.1 - 0.037 13.3 0.0 0.11 11.7 0.0 1.8 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Catalase PF00199.19 EDN11125.1 - 2.3e-166 553.6 0.0 2.9e-166 553.3 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase_C PF18011.1 EDN11125.1 - 6.4e-40 136.3 0.0 1e-39 135.6 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 EDN11125.1 - 8.2e-17 61.2 0.1 1.5e-16 60.3 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive HSP9_HSP12 PF04119.12 EDN11125.1 - 0.12 12.8 0.1 0.3 11.5 0.1 1.6 1 0 0 1 1 1 0 Heat shock protein 9/12 DJ-1_PfpI PF01965.24 EDN11125.1 - 0.2 11.4 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family Glyco_hydro_65N PF03636.15 EDN11126.1 - 1.9e-35 122.5 0.0 2.8e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 EDN11126.1 - 1.1e-24 87.1 0.2 8.6e-20 70.9 0.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 EDN11126.1 - 7.3e-05 22.6 0.1 0.00018 21.3 0.1 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain SMC_Nse1 PF07574.13 EDN11127.1 - 2.6e-70 236.3 0.1 3.9e-70 235.7 0.1 1.3 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex DAO PF01266.24 EDN11127.1 - 6.3e-29 101.7 8.6 3.8e-27 95.8 8.6 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase zf-RING-like PF08746.11 EDN11127.1 - 1.5e-12 47.6 9.3 2.6e-12 46.8 9.3 1.4 1 0 0 1 1 1 1 RING-like domain NAD_binding_8 PF13450.6 EDN11127.1 - 0.00057 20.1 0.3 0.0034 17.6 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EDN11127.1 - 0.095 12.7 0.1 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Peptidase_M57 PF12388.8 EDN11127.1 - 0.11 12.1 0.3 3.4 7.2 0.1 2.4 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase Sacchrp_dh_NADP PF03435.18 EDN11127.1 - 0.23 11.7 0.3 0.69 10.2 0.1 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain zf-RING_2 PF13639.6 EDN11127.1 - 0.92 9.9 8.1 2 8.8 8.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-HC5HC2H PF13771.6 EDN11127.1 - 4.5 7.6 7.1 23 5.3 7.3 1.9 1 1 1 2 2 2 0 PHD-like zinc-binding domain CBFD_NFYB_HMF PF00808.23 EDN11128.1 - 1.1e-15 57.7 1.4 2.2e-15 56.7 1.4 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDN11128.1 - 0.00032 21.1 1.7 0.00038 20.8 0.2 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EDN11128.1 - 0.018 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 EDN11128.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.3 1 1 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit YolD PF08863.10 EDN11128.1 - 0.29 11.2 4.1 0.2 11.7 2.3 1.6 2 0 0 2 2 2 0 YolD-like protein Actin PF00022.19 EDN11129.1 - 2.4e-20 72.6 0.0 5.2e-18 64.8 0.0 2.6 3 0 0 3 3 3 2 Actin MGC-24 PF05283.11 EDN11129.1 - 3.8 8.0 4.8 3.9 7.9 0.1 3.0 3 0 0 3 3 3 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin HTH_Tnp_Tc5 PF03221.16 EDN11131.1 - 0.039 14.0 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain E1_UFD PF09358.10 EDN11131.1 - 0.056 14.2 0.2 0.069 13.9 0.2 1.2 1 0 0 1 1 1 0 Ubiquitin fold domain Glyco_tranf_2_5 PF13712.6 EDN11131.1 - 0.11 12.2 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family Methyltransf_25 PF13649.6 EDN11132.1 - 5.6e-11 43.0 0.0 1.1e-10 42.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN11132.1 - 4.1e-07 30.7 0.0 1.2e-06 29.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11132.1 - 1.1e-06 28.5 0.0 2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN11132.1 - 2.7e-06 27.9 0.0 5.9e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN11132.1 - 8.7e-05 22.4 0.0 0.00022 21.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDN11132.1 - 0.05 12.9 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EDN11132.1 - 0.058 12.9 0.0 0.23 11.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EDN11132.1 - 0.084 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 EDN11133.1 - 1.2e-33 116.5 47.3 1.2e-33 116.5 47.3 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 EDN11134.1 - 1.9e-62 211.5 0.0 6.7e-62 209.8 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EDN11134.1 - 3.9e-17 62.8 0.0 1.2e-16 61.2 0.0 1.9 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.10 EDN11134.1 - 0.0022 17.1 0.0 0.0061 15.6 0.0 1.7 2 0 0 2 2 2 1 Squalene epoxidase Lycopene_cycl PF05834.12 EDN11134.1 - 0.0078 15.3 0.0 0.019 14.0 0.0 1.6 1 1 1 2 2 2 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EDN11134.1 - 0.013 14.4 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 EDN11134.1 - 0.12 11.6 0.1 0.5 9.6 0.1 2.0 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sulfotransfer_4 PF17784.1 EDN11135.1 - 8.6e-72 241.4 0.0 9.9e-72 241.2 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EDN11135.1 - 0.00019 21.9 1.1 0.002 18.5 1.0 2.7 1 1 0 1 1 1 1 Sulfotransferase family NmrA PF05368.13 EDN11136.1 - 1.5e-39 135.9 0.0 2.3e-39 135.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN11136.1 - 9.6e-12 45.2 0.0 1.3e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding AMP-binding PF00501.28 EDN11137.1 - 5.1e-75 252.7 0.0 6.6e-75 252.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EDN11137.1 - 2e-53 181.2 0.0 4.8e-53 180.0 0.0 1.6 2 0 0 2 2 2 1 Male sterility protein PP-binding PF00550.25 EDN11137.1 - 8e-13 48.5 0.7 2.1e-12 47.2 0.3 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Epimerase PF01370.21 EDN11137.1 - 2.6e-08 33.6 0.0 5.2e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDN11137.1 - 0.00013 21.4 0.0 0.00023 20.7 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EDN11137.1 - 0.039 13.0 0.0 0.1 11.6 0.0 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Chromo PF00385.24 EDN11138.1 - 0.00024 20.9 0.2 0.00071 19.4 0.2 1.8 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Kdo PF06293.14 EDN11139.1 - 0.00013 21.4 0.2 0.00035 20.0 0.2 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN11139.1 - 0.001 19.0 0.5 0.024 14.6 0.2 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN11139.1 - 0.0041 16.7 0.0 0.011 15.3 0.0 1.8 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EDN11139.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EDN11139.1 - 0.057 12.8 0.1 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain Leader_CPA1 PF08252.11 EDN11139.1 - 1.5 8.3 7.3 3.1 7.3 0.1 3.2 3 0 0 3 3 3 0 arg-2/CPA1 leader peptide PAPA-1 PF04795.12 EDN11139.1 - 2.6 8.9 6.1 3.8 8.4 3.9 2.5 3 0 0 3 3 3 0 PAPA-1-like conserved region AAA_assoc PF14363.6 EDN11143.1 - 0.22 11.9 0.0 0.37 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA Antimicrobial13 PF08108.11 EDN11143.1 - 0.27 11.4 1.4 0.5 10.5 1.4 1.4 1 0 0 1 1 1 0 Halocidin family AAA PF00004.29 EDN11144.1 - 2.1e-19 70.3 0.0 4.2e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EDN11144.1 - 6e-15 55.7 2.9 8.7e-15 55.2 2.3 1.6 2 0 0 2 2 1 1 BCS1 N terminal AAA_16 PF13191.6 EDN11144.1 - 0.00028 21.3 0.1 0.00091 19.6 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EDN11144.1 - 0.001 18.3 0.0 0.0017 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EDN11144.1 - 0.0014 18.7 0.0 0.0034 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EDN11144.1 - 0.0026 18.0 0.0 0.0058 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDN11144.1 - 0.0033 17.2 0.0 0.0057 16.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN11144.1 - 0.0099 16.4 0.1 0.035 14.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDN11144.1 - 0.039 14.2 0.2 0.16 12.3 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN11144.1 - 0.05 13.8 0.1 0.095 12.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDN11144.1 - 0.054 14.0 0.0 0.15 12.6 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 EDN11144.1 - 0.084 12.6 0.0 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain TIP49 PF06068.13 EDN11144.1 - 0.094 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 EDN11144.1 - 0.12 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 EDN11144.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EDN11144.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.6 EDN11144.1 - 0.13 12.7 0.2 0.26 11.7 0.2 1.6 1 1 0 1 1 1 0 AAA domain Proteasome_A_N PF10584.9 EDN11144.1 - 0.17 11.6 0.3 0.81 9.4 0.0 2.3 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature AAA_11 PF13086.6 EDN11144.1 - 0.17 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDN11144.1 - 0.18 11.8 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Methyltransf_23 PF13489.6 EDN11145.1 - 5.2e-14 52.4 0.0 8.5e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN11145.1 - 2.4e-06 28.2 0.0 7e-06 26.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11145.1 - 6.4e-05 22.8 0.0 0.021 14.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDN11145.1 - 0.0083 16.7 0.0 0.02 15.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain SDA1 PF05285.12 EDN11145.1 - 0.098 12.1 8.9 0.13 11.7 8.9 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EDN11145.1 - 0.11 11.8 6.5 0.15 11.4 6.5 1.2 1 0 0 1 1 1 0 BUD22 Ubie_methyltran PF01209.18 EDN11145.1 - 0.13 11.6 0.0 6.5 6.0 0.0 2.6 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EDN11145.1 - 0.13 11.8 0.0 0.55 9.8 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Pox_Ag35 PF03286.14 EDN11145.1 - 0.58 9.9 6.9 0.85 9.4 6.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sporozoite_P67 PF05642.11 EDN11145.1 - 0.99 7.4 7.4 1.3 7.0 7.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 EDN11145.1 - 1.3 7.2 13.0 1.6 6.8 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 EDN11145.1 - 2 8.1 7.8 3.8 7.2 7.8 1.4 1 0 0 1 1 1 0 FAM176 family Radial_spoke PF04712.12 EDN11145.1 - 3.7 6.4 12.2 5.1 5.9 12.2 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein TRAP_alpha PF03896.16 EDN11145.1 - 4.5 6.4 8.1 75 2.4 10.5 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 EDN11145.1 - 4.9 5.3 10.4 6.7 4.9 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 EDN11145.1 - 5.5 7.4 16.7 11 6.5 16.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4637 PF15470.6 EDN11145.1 - 8.2 6.1 11.9 13 5.5 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Glyco_tranf_2_3 PF13641.6 EDN11146.1 - 2.6e-32 112.6 0.0 3e-32 112.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDN11146.1 - 4.5e-10 39.3 0.0 8.6e-10 38.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDN11146.1 - 2.7e-07 30.6 0.0 5e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 GvpG PF05120.12 EDN11147.1 - 0.031 14.3 1.9 0.095 12.7 1.9 1.9 1 0 0 1 1 1 0 Gas vesicle protein G HSCB_C PF07743.13 EDN11147.1 - 6 7.4 11.6 6.2 7.4 0.4 4.0 5 0 0 5 5 5 0 HSCB C-terminal oligomerisation domain RVT_2 PF07727.14 EDN11149.1 - 3.3e-73 246.3 0.0 5e-73 245.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDN11149.1 - 1.9e-08 34.5 0.0 4.8e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDN11149.1 - 7.9e-06 25.6 0.0 2.6e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain Pkinase PF00069.25 EDN11150.1 - 7.2e-13 48.5 1.3 1.1e-12 48.0 1.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN11150.1 - 1.4e-07 31.0 1.2 2.2e-07 30.4 1.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SRP1_TIP1 PF00660.17 EDN11152.1 - 0.18 11.9 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Seripauperin and TIP1 family DUF3723 PF12520.8 EDN11153.1 - 5.6e-125 417.9 0.7 9.3e-79 265.4 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3723) Patatin PF01734.22 EDN11154.1 - 7e-09 36.1 1.9 3.4e-05 24.1 0.4 3.0 3 0 0 3 3 3 2 Patatin-like phospholipase DUF3435 PF11917.8 EDN11157.1 - 2.5e-156 520.8 0.1 3.7e-156 520.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Pox_Ag35 PF03286.14 EDN11157.1 - 1.1 9.0 7.3 2.3 8.0 7.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BSP_II PF05432.11 EDN11157.1 - 1.5 8.4 13.1 2.4 7.8 13.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2428 PF10350.9 EDN11157.1 - 2.4 7.3 4.3 5.1 6.3 4.3 1.5 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) PPL5 PF18168.1 EDN11157.1 - 3.3 6.9 6.2 6.1 6.0 6.2 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF3682 PF12446.8 EDN11157.1 - 5.2 7.6 10.7 10 6.6 10.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) RVT_1 PF00078.27 EDN11159.1 - 1e-11 44.8 0.0 1.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDN11159.1 - 1.8e-11 44.4 0.0 4.7e-11 43.0 0.0 1.7 1 1 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EDN11159.1 - 1.1e-09 38.2 0.0 3.5e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase ORF_12_N PF18042.1 EDN11159.1 - 0.17 12.3 2.9 0.18 12.3 0.5 2.3 3 0 0 3 3 3 0 ORF 12 gene product N-terminal DDE_Tnp_1_7 PF13843.6 EDN11160.1 - 1.3e-15 57.6 1.6 3.1e-07 30.0 0.5 2.1 1 1 1 2 2 2 2 Transposase IS4 DUF4551 PF15087.6 EDN11164.1 - 5.6 5.7 33.5 6.3 5.5 33.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Piwi PF02171.17 EDN11165.1 - 1.1e-15 57.7 0.0 1.3e-15 57.5 0.0 1.0 1 0 0 1 1 1 1 Piwi domain RHH_5 PF07878.11 EDN11165.1 - 0.069 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 DKNYY PF13644.6 EDN11165.1 - 0.19 12.5 0.0 0.25 12.1 0.0 1.2 1 0 0 1 1 1 0 DKNYY family Transket_pyr PF02779.24 EDN11166.1 - 6.9e-45 152.9 0.0 1.4e-44 151.9 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDN11166.1 - 9.6e-34 115.9 0.1 2.6e-33 114.5 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain Metallophos PF00149.28 EDN11168.1 - 2.6e-11 44.4 2.4 5.1e-11 43.5 2.4 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EDN11168.1 - 0.14 12.3 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain ADH_zinc_N PF00107.26 EDN11169.1 - 1.1e-12 48.1 0.0 1.9e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDN11169.1 - 0.013 15.4 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Ank_2 PF12796.7 EDN11170.1 - 3.6e-14 53.1 0.0 6.2e-07 29.9 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDN11170.1 - 4.7e-11 42.7 0.4 1.3e-09 38.1 0.1 3.2 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EDN11170.1 - 4.8e-09 36.3 0.0 0.00025 21.3 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EDN11170.1 - 2.4e-07 31.2 0.1 0.00082 19.9 0.0 3.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SesA PF17107.5 EDN11170.1 - 1.1e-05 25.7 0.1 2.9e-05 24.2 0.1 1.8 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Ank_3 PF13606.6 EDN11170.1 - 0.00058 20.1 0.0 4.6 8.1 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Helo_like_N PF17111.5 EDN11170.1 - 0.011 15.1 0.3 0.027 13.8 0.3 1.6 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Amidase PF01425.21 EDN11171.1 - 3.7e-117 392.0 0.2 7.3e-117 391.1 0.2 1.4 1 1 0 1 1 1 1 Amidase Big_3_5 PF16640.5 EDN11171.1 - 0.3 11.3 3.1 1.6 9.0 2.3 2.5 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 3) Rrn6 PF10214.9 EDN11172.1 - 2.5 6.5 8.5 3.6 6.0 8.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Bystin PF05291.11 EDN11173.1 - 1.3e-119 398.9 0.0 1.7e-119 398.5 0.0 1.1 1 0 0 1 1 1 1 Bystin bZIP_2 PF07716.15 EDN11175.1 - 4.2e-10 39.5 11.5 4.2e-10 39.5 11.5 2.4 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EDN11175.1 - 6.8e-07 29.3 14.6 1.3e-06 28.4 14.1 1.7 1 1 1 2 2 2 2 bZIP transcription factor bZIP_Maf PF03131.17 EDN11175.1 - 0.0042 17.6 11.7 0.0064 17.0 11.7 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor Anti-adapt_IraP PF10796.9 EDN11175.1 - 0.11 13.1 0.4 0.2 12.2 0.4 1.3 1 0 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein DUF3450 PF11932.8 EDN11175.1 - 0.2 10.9 6.3 0.31 10.3 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 EDN11175.1 - 0.41 11.2 11.6 0.67 10.5 11.6 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region KIAA1430 PF13879.6 EDN11175.1 - 0.67 10.7 7.7 0.88 10.4 5.9 2.0 1 1 1 2 2 2 0 KIAA1430 homologue Glyco_hydro_43 PF04616.14 EDN11178.1 - 3.2e-36 125.1 0.1 3.8e-26 92.1 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 43 zf-C2H2 PF00096.26 EDN11179.1 - 0.013 15.9 1.2 0.013 15.9 1.2 1.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-LYAR PF08790.11 EDN11179.1 - 0.051 13.5 0.2 0.086 12.8 0.2 1.4 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_jaz PF12171.8 EDN11179.1 - 0.064 13.6 1.6 0.1 12.9 1.6 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDN11179.1 - 0.093 13.2 0.3 0.16 12.4 0.3 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDN11179.1 - 0.12 13.3 0.6 0.26 12.2 0.6 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1691 PF07950.11 EDN11180.1 - 1.7e-37 128.4 6.8 5.3e-31 107.5 6.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Iso_dh PF00180.20 EDN11181.1 - 9.4e-101 337.4 0.0 1.1e-100 337.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase TRM PF02005.16 EDN11182.1 - 3.6e-110 368.7 0.0 1e-97 327.7 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EDN11182.1 - 0.00042 20.1 0.0 0.00079 19.2 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein SRRM_C PF15230.6 EDN11182.1 - 0.12 13.0 11.9 0.097 13.3 0.5 3.4 4 0 0 4 4 4 0 Serine/arginine repetitive matrix protein C-terminus FAS_I_H PF18314.1 EDN11183.1 - 6.6e-78 261.0 0.0 1.9e-77 259.5 0.0 1.9 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EDN11183.1 - 1.2e-75 253.3 0.0 3e-75 252.0 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EDN11183.1 - 3e-20 72.9 0.0 6.1e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EDN11183.1 - 8.2e-17 61.4 0.0 2e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EDN11183.1 - 1.8e-10 40.9 0.0 4.7e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EDN11183.1 - 3.8e-05 23.2 0.0 0.00013 21.5 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN11183.1 - 0.00025 20.7 0.0 0.0019 17.8 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDN11183.1 - 0.0079 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 KR domain PnpCD_PnpD_N PF18191.1 EDN11183.1 - 0.087 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Hydroquinone 1,2-dioxygenase large subunit N-terminal FAM60A PF15396.6 EDN11183.1 - 0.15 12.1 0.5 0.41 10.6 0.5 1.7 1 0 0 1 1 1 0 Protein Family FAM60A DUF1729 PF08354.10 EDN11184.1 - 2.2e-161 536.7 0.0 3.2e-161 536.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EDN11184.1 - 8.1e-92 308.1 0.0 4.6e-90 302.4 0.0 3.0 4 0 0 4 4 4 1 Acyl transferase domain FAS_meander PF17951.1 EDN11184.1 - 1.4e-53 180.6 0.0 3.6e-53 179.3 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain FAS_N PF17828.1 EDN11184.1 - 3.8e-43 146.6 0.0 1.3e-42 144.9 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 EDN11184.1 - 1.3e-37 128.1 0.4 2.6e-37 127.1 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain SAT PF16073.5 EDN11184.1 - 1.5e-36 126.3 0.0 4.4e-36 124.8 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 EDN11184.1 - 1.4e-21 77.0 0.0 4.1e-21 75.5 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase TFIIF_alpha PF05793.12 EDN11185.1 - 6.4e-07 28.3 70.6 1.6e-06 27.0 60.2 3.9 1 1 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Rep-A_N PF04057.12 EDN11186.1 - 0.00056 19.9 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain BRCA-2_OB1 PF09103.10 EDN11186.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 DUF383 PF04063.14 EDN11187.1 - 1.3e-65 220.7 0.0 5.1e-65 218.7 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EDN11187.1 - 8.3e-23 80.0 3.0 1.1e-22 79.6 1.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF384) MlaA PF04333.13 EDN11187.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 MlaA lipoprotein Inositol_P PF00459.25 EDN11188.1 - 3.1e-64 217.1 0.0 1.5e-63 214.9 0.0 1.8 1 1 0 1 1 1 1 Inositol monophosphatase family IBR PF01485.21 EDN11190.1 - 5.9e-12 45.6 37.8 8.7e-07 29.1 5.0 3.7 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EDN11190.1 - 0.0021 18.0 6.8 0.0021 18.0 6.8 3.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_5 PF17121.5 EDN11190.1 - 0.016 15.1 2.8 0.016 15.1 2.8 3.2 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF455 PF04305.14 EDN11191.1 - 1.6e-99 332.5 0.1 2.7e-99 331.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske PF00355.26 EDN11191.1 - 2.2e-06 27.5 0.0 4.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EDN11191.1 - 0.0038 17.1 0.0 0.016 15.2 0.0 2.1 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain His_Phos_2 PF00328.22 EDN11192.1 - 4.3e-105 352.2 0.0 6.4e-105 351.6 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF676 PF05057.14 EDN11192.1 - 5.8e-39 133.9 0.0 8.4e-27 94.1 0.0 3.3 2 1 1 3 3 3 3 Putative serine esterase (DUF676) PPIP5K2_N PF18086.1 EDN11192.1 - 3.8e-38 129.5 0.0 8.9e-38 128.3 0.0 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain DAGK_cat PF00781.24 EDN11192.1 - 1.8e-07 30.8 0.1 4.3e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RimK PF08443.11 EDN11192.1 - 0.00014 21.6 0.0 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Utp21 PF04192.12 EDN11193.1 - 2e-82 276.2 0.0 3e-82 275.6 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EDN11193.1 - 1.8e-17 63.4 24.6 5.6e-05 23.8 0.2 10.6 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN11193.1 - 3e-13 49.9 0.0 0.046 14.0 0.1 6.0 2 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDN11193.1 - 0.0098 14.6 0.1 4.3 5.9 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EDN11193.1 - 0.014 14.3 0.9 8 5.3 0.0 3.6 3 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain FeoB_associated PF12669.7 EDN11194.1 - 0.016 15.6 1.2 0.025 15.0 1.2 1.2 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF3328 PF11807.8 EDN11194.1 - 0.18 11.6 0.1 0.29 10.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF4307 PF14155.6 EDN11194.1 - 0.8 9.6 2.4 1.6 8.6 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) XPG_I_2 PF12813.7 EDN11195.1 - 1.1e-87 293.7 0.0 1.4e-87 293.3 0.0 1.1 1 0 0 1 1 1 1 XPG domain containing Fcf1 PF04900.12 EDN11196.1 - 3.3e-38 130.1 0.3 6.1e-38 129.2 0.3 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EDN11196.1 - 2.7e-12 47.0 0.1 5.7e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 PIN like domain FA_hydroxylase PF04116.13 EDN11197.1 - 6e-27 94.6 16.7 9.7e-27 93.9 16.7 1.3 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily NCA2 PF08637.10 EDN11198.1 - 9.4e-88 294.1 0.0 2.6e-87 292.7 0.0 1.8 1 1 0 1 1 1 1 ATP synthase regulation protein NCA2 RAG1 PF12940.7 EDN11199.1 - 0.16 10.0 0.0 0.2 9.7 0.0 1.0 1 0 0 1 1 1 0 Recombination-activation protein 1 (RAG1), recombinase zf-C2H2 PF00096.26 EDN11200.1 - 0.43 11.1 7.9 5.3 7.7 0.1 4.3 4 0 0 4 4 4 0 Zinc finger, C2H2 type Peptidase_S8 PF00082.22 EDN11201.1 - 5.6e-18 65.2 0.0 1.3e-17 64.0 0.0 1.6 1 1 0 1 1 1 1 Subtilase family Ras PF00071.22 EDN11206.1 - 1.6e-65 219.6 0.1 2e-65 219.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDN11206.1 - 9.2e-34 116.2 0.0 1.6e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDN11206.1 - 2.1e-13 50.1 0.1 2.6e-13 49.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDN11206.1 - 1.7e-05 24.5 0.2 9.9e-05 22.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDN11206.1 - 0.00022 20.6 0.0 0.00026 20.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EDN11206.1 - 0.00057 19.8 0.3 0.53 10.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDN11206.1 - 0.0038 17.3 0.0 0.0068 16.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDN11206.1 - 0.035 13.6 0.0 0.23 11.0 0.0 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 EDN11208.1 - 4e-60 202.0 0.0 3.1e-40 137.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN11208.1 - 8.6e-20 70.3 0.2 1.2e-11 44.2 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EDN11208.1 - 2.9e-09 37.5 4.6 0.021 15.2 0.3 4.4 2 2 0 4 4 4 2 AAA ATPase domain AAA_28 PF13521.6 EDN11208.1 - 1.6e-06 28.4 0.0 0.0034 17.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EDN11208.1 - 1.8e-06 27.7 0.1 0.062 12.9 0.1 3.6 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 EDN11208.1 - 2.3e-06 27.9 4.5 0.088 13.1 1.4 4.2 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EDN11208.1 - 2.5e-06 27.5 1.7 0.024 14.7 0.1 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EDN11208.1 - 3.1e-06 27.5 0.0 0.074 13.4 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EDN11208.1 - 4.1e-06 26.9 0.0 0.063 13.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EDN11208.1 - 1.6e-05 25.0 0.0 0.0045 16.9 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EDN11208.1 - 2.4e-05 24.2 0.0 0.033 13.9 0.0 3.4 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDN11208.1 - 6.9e-05 22.6 0.0 0.16 11.7 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein TIP49 PF06068.13 EDN11208.1 - 0.00011 21.5 0.4 0.00084 18.6 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_7 PF12775.7 EDN11208.1 - 0.00014 21.4 0.3 0.64 9.5 0.0 2.5 3 0 0 3 3 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 EDN11208.1 - 0.00074 19.3 0.1 0.042 13.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EDN11208.1 - 0.00086 19.5 0.0 0.0057 16.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Bac_DnaA PF00308.18 EDN11208.1 - 0.00097 19.0 0.0 0.083 12.7 0.0 3.2 2 2 0 2 2 2 1 Bacterial dnaA protein Mg_chelatase PF01078.21 EDN11208.1 - 0.0012 18.3 1.2 0.061 12.7 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EDN11208.1 - 0.0016 18.6 0.0 0.81 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDN11208.1 - 0.0018 18.8 0.0 0.29 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDN11208.1 - 0.0021 17.8 0.1 0.02 14.7 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.13 EDN11208.1 - 0.0036 16.5 0.0 3.1 6.9 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EDN11208.1 - 0.0064 16.4 1.0 0.48 10.3 0.2 2.8 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EDN11208.1 - 0.015 15.2 5.9 1.9 8.4 0.6 3.9 3 1 1 4 4 4 0 NACHT domain AAA_11 PF13086.6 EDN11208.1 - 0.016 15.0 0.0 5.2 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDN11208.1 - 0.025 15.1 0.0 0.064 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDN11208.1 - 0.035 14.1 0.1 4.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDN11208.1 - 0.036 13.8 0.3 2.7 7.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 EDN11208.1 - 0.17 11.0 0.5 0.49 9.5 0.1 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Adeno_IVa2 PF02456.15 EDN11208.1 - 0.19 10.5 0.1 0.96 8.2 0.1 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein ABC_tran PF00005.27 EDN11208.1 - 0.48 10.9 3.9 3.2 8.3 0.5 2.5 2 0 0 2 2 2 0 ABC transporter PI3_PI4_kinase PF00454.27 EDN11211.1 - 1.1e-53 182.6 0.0 2.4e-53 181.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EDN11211.1 - 3.8e-41 141.5 0.6 1.4e-40 139.6 0.6 2.1 1 0 0 1 1 1 1 FAT domain UME PF08064.13 EDN11211.1 - 3.8e-33 113.4 0.4 3.8e-33 113.4 0.4 3.7 4 0 0 4 4 4 1 UME (NUC010) domain FATC PF02260.20 EDN11211.1 - 3.8e-12 45.8 0.0 1e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 FATC domain DUF3385 PF11865.8 EDN11211.1 - 0.077 12.9 0.1 1.7 8.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) dCMP_cyt_deam_1 PF00383.23 EDN11212.1 - 1.5e-11 44.0 0.0 2.1e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDN11212.1 - 1.4e-06 28.1 0.0 1.9e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase NADH_u_ox_C PF12853.7 EDN11213.1 - 1.2e-27 95.7 0.3 6.2e-27 93.4 0.1 1.9 2 0 0 2 2 2 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit NADH-u_ox-rdase PF10785.9 EDN11213.1 - 2.1e-19 70.0 5.9 7.4e-18 65.0 5.9 2.3 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Dzip-like_N PF13815.6 EDN11214.1 - 0.022 14.8 3.8 0.053 13.5 3.8 1.6 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF5041 PF16444.5 EDN11214.1 - 0.041 14.2 1.3 0.051 13.8 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5041) EMC3_TMCO1 PF01956.16 EDN11214.1 - 0.068 12.9 2.5 0.091 12.5 2.5 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like G5 PF07501.12 EDN11214.1 - 0.16 12.4 3.6 0.33 11.4 3.3 1.8 1 1 0 1 1 1 0 G5 domain COX16 PF14138.6 EDN11215.1 - 1.6e-32 111.8 0.1 2e-32 111.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Nic96 PF04097.14 EDN11216.1 - 3e-219 729.6 0.0 4e-219 729.2 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.6 EDN11216.1 - 9.2 7.2 33.4 0.036 14.9 19.3 3.3 4 0 0 4 4 4 0 Nucleoporin FG repeat region RibD_C PF01872.17 EDN11217.1 - 1.7e-30 106.4 0.0 2.7e-30 105.7 0.0 1.3 1 0 0 1 1 1 1 RibD C-terminal domain CAP_N PF01213.19 EDN11217.1 - 0.06 12.8 2.8 0.12 11.8 2.8 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RCC1 PF00415.18 EDN11219.1 - 3.8e-52 174.7 9.3 8.2e-09 36.0 0.1 7.7 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDN11219.1 - 2e-32 110.3 37.8 1.5e-08 34.2 0.9 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Swi3 PF07962.12 EDN11220.1 - 2.2e-33 114.1 0.2 3.5e-33 113.4 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Pkinase_fungal PF17667.1 EDN11221.1 - 6.9e-142 473.0 0.0 8.4e-142 472.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN11221.1 - 6e-07 29.1 0.0 9.9e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN11221.1 - 0.027 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN11221.1 - 0.059 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Y_phosphatase PF00102.27 EDN11222.1 - 2.5e-55 187.6 0.0 1e-53 182.4 0.0 2.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EDN11222.1 - 1.1e-09 38.7 0.0 4.9e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EDN11222.1 - 0.016 15.1 0.1 0.039 13.8 0.1 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain F-box PF00646.33 EDN11225.1 - 0.0031 17.4 0.0 0.0063 16.4 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDN11225.1 - 0.02 14.8 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 F-box-like FGGY_C PF02782.16 EDN11227.1 - 9.7e-53 178.8 0.2 1.5e-52 178.2 0.2 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDN11227.1 - 3.1e-23 82.6 0.0 4.6e-22 78.8 0.0 2.3 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EDN11227.1 - 0.016 14.7 0.1 0.066 12.7 0.0 1.9 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DEDD_Tnp_IS110 PF01548.17 EDN11227.1 - 0.11 12.4 0.9 1 9.2 0.2 2.4 2 0 0 2 2 2 0 Transposase Na_Ca_ex PF01699.24 EDN11228.1 - 1.2e-15 57.7 11.5 1.2e-15 57.7 11.5 5.0 6 0 0 6 6 6 2 Sodium/calcium exchanger protein YccF PF03733.13 EDN11228.1 - 1.2e-13 51.5 8.7 1.2e-13 51.5 8.7 4.5 5 0 0 5 5 5 1 Inner membrane component domain CbtB PF09489.10 EDN11228.1 - 2.2 8.5 4.8 0.92 9.7 0.4 2.6 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) AAA PF00004.29 EDN11229.1 - 1.1e-43 148.8 0.0 1.8e-43 148.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDN11229.1 - 4.6e-14 51.9 0.0 1e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EDN11229.1 - 2e-07 31.3 0.0 3.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDN11229.1 - 9.9e-07 29.3 0.1 4.7e-05 23.8 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EDN11229.1 - 1.3e-06 28.5 0.0 3.4e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_ID_OB PF16450.5 EDN11229.1 - 4.2e-06 26.6 2.7 1.1e-05 25.3 2.7 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EDN11229.1 - 1.9e-05 24.9 0.2 0.0063 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EDN11229.1 - 6.4e-05 22.7 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDN11229.1 - 0.001 19.6 0.1 0.029 14.9 0.0 2.7 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EDN11229.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EDN11229.1 - 0.0011 18.2 0.0 0.0023 17.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EDN11229.1 - 0.0021 18.2 0.0 0.0042 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDN11229.1 - 0.0054 16.6 0.0 0.016 15.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EDN11229.1 - 0.0082 15.5 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EDN11229.1 - 0.0087 15.4 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 KaiC TsaE PF02367.17 EDN11229.1 - 0.012 15.6 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EDN11229.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Prot_ATP_OB_N PF17758.1 EDN11229.1 - 0.014 15.0 0.2 0.049 13.3 0.2 2.0 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain DUF815 PF05673.13 EDN11229.1 - 0.019 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EDN11229.1 - 0.022 14.5 0.0 0.098 12.4 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain PhoH PF02562.16 EDN11229.1 - 0.026 14.0 0.0 0.098 12.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EDN11229.1 - 0.027 14.0 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EDN11229.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain HR1 PF02185.16 EDN11229.1 - 0.042 14.0 0.7 0.11 12.7 0.7 1.7 1 0 0 1 1 1 0 Hr1 repeat AAA_14 PF13173.6 EDN11229.1 - 0.043 13.8 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDN11229.1 - 0.05 14.0 0.0 0.09 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EDN11229.1 - 0.067 12.8 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EDN11229.1 - 0.091 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 EDN11229.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain F-box-like PF12937.7 EDN11230.1 - 2.4e-05 24.1 0.1 6.9e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like CobW_C PF07683.14 EDN11230.1 - 0.036 14.0 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain F-box PF00646.33 EDN11230.1 - 0.038 13.9 0.3 0.12 12.3 0.3 1.8 1 0 0 1 1 1 0 F-box domain TMF_TATA_bd PF12325.8 EDN11230.1 - 0.04 14.1 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding UFD1 PF03152.14 EDN11231.1 - 1.6e-28 99.4 0.0 1.1e-15 57.5 0.0 3.8 4 0 0 4 4 4 3 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EDN11231.1 - 3.2e-06 27.3 0.1 1.7e-05 24.9 0.1 2.4 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A MCR PF18509.1 EDN11231.1 - 1.6 8.4 5.4 7.9 6.2 0.6 3.1 2 0 0 2 2 2 0 Magnetochrome domain TF_Zn_Ribbon PF08271.12 EDN11231.1 - 4.9 6.8 7.9 6.7 6.3 0.0 4.0 4 0 0 4 4 4 0 TFIIB zinc-binding Bac_surface_Ag PF01103.23 EDN11232.1 - 7.3e-37 127.6 0.0 1.2e-36 126.9 0.0 1.3 1 0 0 1 1 1 1 Surface antigen Yip1 PF04893.17 EDN11232.1 - 1.4e-05 24.9 14.0 0.00096 18.9 7.2 2.6 2 0 0 2 2 2 2 Yip1 domain YkyA PF10368.9 EDN11232.1 - 0.042 13.5 0.8 0.066 12.9 0.8 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein UQ_con PF00179.26 EDN11233.1 - 3.1e-05 23.6 0.0 4.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme APH PF01636.23 EDN11235.1 - 0.065 13.1 0.0 0.093 12.6 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Fungal_trans_2 PF11951.8 EDN11237.1 - 2.3e-07 30.0 0.0 5.1e-07 28.8 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain TFIIA PF03153.13 EDN11237.1 - 4.3 7.2 18.7 6.8 6.6 18.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cyto_heme_lyase PF01265.17 EDN11238.1 - 1.6e-119 398.9 0.2 1.8e-119 398.7 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase DUF676 PF05057.14 EDN11239.1 - 0.0011 18.6 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF4386 PF14329.6 EDN11239.1 - 0.0067 16.3 1.1 0.011 15.6 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4386) Lipase_3 PF01764.25 EDN11239.1 - 0.0075 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EDN11239.1 - 0.029 15.0 0.0 0.055 14.1 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.12 EDN11239.1 - 0.092 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EDN11239.1 - 0.36 10.5 0.9 0.76 9.4 0.9 1.5 1 1 0 1 1 1 0 PGAP1-like protein ABC1 PF03109.16 EDN11240.1 - 7.7e-21 74.5 0.0 1.6e-17 63.7 0.0 2.4 1 1 0 1 1 1 1 ABC1 family Raf1_HTH PF18579.1 EDN11240.1 - 0.017 14.8 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain RIO1 PF01163.22 EDN11240.1 - 0.035 13.7 0.0 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 RIO1 family SLAC1 PF03595.17 EDN11241.1 - 1.9e-80 270.6 47.7 2.2e-80 270.3 47.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Pro_CA PF00484.19 EDN11242.1 - 8.8e-15 55.3 0.0 1.3e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase adh_short PF00106.25 EDN11243.1 - 1.2e-33 116.2 0.1 1.6e-33 115.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDN11243.1 - 4.9e-22 78.6 0.0 7e-22 78.1 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 EDN11243.1 - 0.033 13.8 0.0 0.046 13.3 0.0 1.5 1 1 0 1 1 1 0 NmrA-like family ADH_zinc_N PF00107.26 EDN11243.1 - 0.041 13.9 0.1 1.5 8.8 0.0 2.3 1 1 0 2 2 2 0 Zinc-binding dehydrogenase Epimerase PF01370.21 EDN11243.1 - 0.067 12.6 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family ATP-grasp_2 PF08442.10 EDN11244.1 - 1.9e-77 259.4 1.6 1.9e-77 259.4 1.6 1.6 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EDN11244.1 - 7e-25 87.6 0.3 1.8e-24 86.3 0.3 1.7 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EDN11244.1 - 9.1e-10 38.4 1.8 1.2e-09 37.9 0.7 1.7 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EDN11244.1 - 0.0022 17.8 2.4 0.0089 15.8 0.3 2.6 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain B2 PF11473.8 EDN11244.1 - 0.0057 16.4 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA binding protein B2 DUF3245 PF11595.8 EDN11245.1 - 3.3e-50 170.5 4.1 3.3e-50 170.5 4.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3245) HSF_DNA-bind PF00447.17 EDN11246.1 - 5.3e-20 71.8 0.7 1.2e-19 70.7 0.7 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding DUF4763 PF15960.5 EDN11246.1 - 0.14 11.4 0.5 0.23 10.7 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Pribosyltran PF00156.27 EDN11247.1 - 8.9e-05 22.1 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DPM3 PF08285.11 EDN11248.1 - 4.6e-14 52.4 0.0 4.9e-14 52.3 0.0 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) KAP PF05804.12 EDN11249.1 - 1.9e-07 29.7 0.0 6.7e-05 21.2 0.0 2.2 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) SIR2_2 PF13289.6 EDN11249.1 - 0.061 13.4 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 SIR2-like domain DUF383 PF04063.14 EDN11249.1 - 0.11 12.2 0.5 1.7 8.3 0.0 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF383) Oxidored-like PF09791.9 EDN11250.1 - 1.8e-23 81.9 4.5 4.3e-23 80.7 4.5 1.7 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF5522 PF17653.1 EDN11250.1 - 0.066 13.2 3.4 0.2 11.6 3.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5522) Actin PF00022.19 EDN11251.1 - 1.7e-92 310.2 0.0 1.2e-90 304.1 0.0 2.9 1 1 1 2 2 2 2 Actin GCIP PF13324.6 EDN11252.1 - 4.5e-18 65.8 0.1 9.3e-18 64.8 0.1 1.4 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting LRR_4 PF12799.7 EDN11253.1 - 9.6e-28 95.8 61.0 3.7e-06 27.2 1.0 10.3 4 3 10 14 14 14 14 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDN11253.1 - 2e-27 94.7 55.2 7.6e-08 32.0 5.1 7.9 5 2 0 7 7 7 7 Leucine rich repeat LRR_1 PF00560.33 EDN11253.1 - 2.7e-07 30.2 36.1 4.9 8.1 0.4 11.4 10 4 0 10 10 10 4 Leucine Rich Repeat LRR_9 PF14580.6 EDN11253.1 - 0.0006 19.4 19.0 0.44 10.0 1.3 4.8 2 2 4 6 6 6 5 Leucine-rich repeat YonK PF09642.10 EDN11253.1 - 0.16 12.2 0.7 1.5 9.0 0.0 3.0 4 0 0 4 4 4 0 YonK protein LRR_6 PF13516.6 EDN11253.1 - 0.34 11.1 44.3 0.49 10.6 0.1 10.8 12 0 0 12 12 12 0 Leucine Rich repeat KASH_CCD PF14662.6 EDN11254.1 - 0.022 14.6 1.8 0.022 14.6 1.8 2.3 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Ribosomal_L13e PF01294.18 EDN11255.1 - 8.5e-77 257.1 2.6 1.3e-76 256.4 2.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e Nucleo_P87 PF07267.11 EDN11257.1 - 0.85 8.4 6.5 0.39 9.5 4.1 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 HTH_7 PF02796.15 EDN11258.1 - 0.0044 17.1 0.0 0.012 15.6 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 EDN11258.1 - 0.036 13.8 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain BCS1_N PF08740.11 EDN11259.1 - 1.5e-34 119.6 0.1 2.4e-34 119.0 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDN11259.1 - 6.7e-10 39.5 0.0 1.7e-08 34.9 0.0 2.5 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN11259.1 - 0.014 15.8 0.1 0.083 13.3 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EDN11259.1 - 0.026 15.1 0.0 5.5 7.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 EDN11259.1 - 0.035 13.8 0.0 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EDN11259.1 - 0.036 12.9 0.0 0.06 12.2 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase ATPase PF06745.13 EDN11259.1 - 0.055 12.8 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 EDN11259.1 - 0.06 13.5 0.3 2.6 8.2 0.1 2.5 2 1 0 2 2 2 0 AAA domain Bac_export_2 PF01312.19 EDN11259.1 - 0.11 11.7 0.1 0.15 11.3 0.1 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family AAA_5 PF07728.14 EDN11259.1 - 0.14 12.1 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDN11259.1 - 0.14 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EDN11259.1 - 0.17 11.4 0.0 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain bZIP_2 PF07716.15 EDN11260.1 - 4.6e-08 33.0 4.9 9.4e-08 32.0 4.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDN11260.1 - 2.9e-07 30.5 5.2 5.4e-07 29.6 5.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EDN11260.1 - 0.53 10.8 8.7 0.096 13.2 4.4 2.0 2 0 0 2 2 2 0 bZIP Maf transcription factor DDE_1 PF03184.19 EDN11262.1 - 8e-30 103.8 0.0 3.5e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN11262.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase_fungal PF17667.1 EDN11263.1 - 2.6e-125 418.4 0.0 3.3e-125 418.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase MauJ PF17419.2 EDN11263.1 - 0.073 12.5 0.1 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 Methylamine utilization protein MauJ Caskin-Pro-rich PF16907.5 EDN11263.1 - 0.23 12.0 7.4 5.1 7.7 1.2 2.6 2 0 0 2 2 2 0 Proline rich region of Caskin proteins SRF-TF PF00319.18 EDN11265.1 - 4e-07 29.4 0.3 0.00015 21.2 0.2 2.5 2 1 0 2 2 2 2 SRF-type transcription factor (DNA-binding and dimerisation domain) DarT PF14487.6 EDN11265.1 - 0.04 13.8 0.5 0.04 13.8 0.5 1.6 2 0 0 2 2 2 0 ssDNA thymidine ADP-ribosyltransferase, DarT GRIN_C PF15235.6 EDN11265.1 - 0.98 9.7 4.1 4.6 7.5 0.3 2.1 1 1 1 2 2 2 0 G protein-regulated inducer of neurite outgrowth C-terminus Pkinase PF00069.25 EDN11266.1 - 2.4e-08 33.7 0.0 1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EDN11266.1 - 4.1e-05 23.0 0.0 6.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN11266.1 - 0.00011 22.2 0.0 0.00076 19.5 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDN11266.1 - 0.00045 19.9 0.0 0.0011 18.6 0.0 1.6 1 1 0 1 1 1 1 RIO1 family Alpha_L_fucos PF01120.17 EDN11266.1 - 0.039 13.4 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 Alpha-L-fucosidase WaaY PF06176.11 EDN11266.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) HIF-1 PF11413.8 EDN11266.1 - 0.3 10.5 1.7 0.64 9.5 1.7 1.6 1 0 0 1 1 1 0 Hypoxia-inducible factor-1 SCAN PF02023.17 EDN11267.1 - 0.036 13.9 1.6 0.067 13.0 1.6 1.4 1 0 0 1 1 1 0 SCAN domain Rep-A_N PF04057.12 EDN11267.1 - 0.17 11.9 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Swm2 PF17083.5 EDN11267.1 - 0.17 11.9 0.3 0.27 11.2 0.3 1.2 1 0 0 1 1 1 0 Nucleolar protein Swm2 OMP_b-brl PF13505.6 EDN11268.1 - 0.0064 16.6 0.8 0.0082 16.3 0.8 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain MetallophosC PF16370.5 EDN11268.1 - 0.0066 16.7 1.8 0.0073 16.6 1.8 1.2 1 0 0 1 1 1 1 C terminal of Calcineurin-like phosphoesterase Haemagg_act PF05860.13 EDN11268.1 - 0.87 9.5 12.9 1.2 9.0 12.9 1.4 1 1 0 1 1 1 0 haemagglutination activity domain Evf PF18270.1 EDN11268.1 - 3 7.2 10.6 0.85 9.0 1.8 2.0 1 1 1 2 2 2 0 Virulence factor Evf ECH_1 PF00378.20 EDN11270.1 - 1.6e-13 50.6 0.1 1.8e-13 50.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase TIMELESS PF04821.14 EDN11271.1 - 2e-60 204.5 1.5 4.9e-50 170.3 0.0 2.6 1 1 1 2 2 2 2 Timeless protein TIMELESS_C PF05029.13 EDN11271.1 - 1.6e-50 172.9 15.7 7.5e-43 147.5 0.0 3.2 2 1 1 3 3 3 3 Timeless protein C terminal region UCH PF00443.29 EDN11271.1 - 0.013 15.0 1.1 0.23 10.9 0.1 3.1 2 1 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase Toxin_10 PF05431.11 EDN11271.1 - 0.18 11.2 0.8 0.43 10.0 0.2 1.8 2 0 0 2 2 2 0 Insecticidal Crystal Toxin, P42 DUF4778 PF16008.5 EDN11271.1 - 6.6 6.7 15.7 12 5.8 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4778) 3HCDH_N PF02737.18 EDN11272.1 - 4.7e-54 183.0 2.3 6.6e-54 182.5 2.3 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EDN11272.1 - 3.5e-34 117.3 0.1 1.3e-33 115.4 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ApbA PF02558.16 EDN11272.1 - 1.2e-06 28.3 0.2 0.00043 20.0 0.1 2.3 1 1 0 2 2 2 2 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 EDN11272.1 - 5.9e-06 26.5 0.4 1.6e-05 25.2 0.4 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EDN11272.1 - 0.00014 22.1 0.1 0.0003 21.1 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EDN11272.1 - 0.00033 20.3 0.0 0.00062 19.4 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EDN11272.1 - 0.003 16.9 0.2 0.0055 16.0 0.2 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EDN11272.1 - 0.0033 16.7 0.0 0.0045 16.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 EDN11272.1 - 0.0063 16.5 0.2 0.011 15.8 0.2 1.5 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus RsbU_N PF08673.10 EDN11272.1 - 0.0083 16.2 0.1 0.019 15.0 0.1 1.5 1 0 0 1 1 1 1 Phosphoserine phosphatase RsbU, N-terminal domain DAO PF01266.24 EDN11272.1 - 0.011 15.4 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EDN11272.1 - 0.017 14.5 0.3 0.035 13.5 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAHP_synth_1 PF00793.20 EDN11272.1 - 0.082 11.8 0.7 0.71 8.7 0.1 2.2 1 1 0 2 2 2 0 DAHP synthetase I family NAD_binding_7 PF13241.6 EDN11272.1 - 0.084 13.3 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EDN11272.1 - 0.1 12.7 0.2 0.26 11.4 0.2 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EDN11272.1 - 0.11 13.0 0.2 0.26 11.9 0.1 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase RVT_1 PF00078.27 EDN11275.1 - 3.2e-11 43.2 0.1 7.2e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 EDN11275.1 - 0.018 15.8 2.1 0.086 13.7 2.1 2.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN11275.1 - 0.035 14.6 3.9 0.12 12.9 2.9 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 EDN11275.1 - 0.078 12.8 1.8 0.18 11.6 1.8 1.5 1 0 0 1 1 1 0 zinc-finger C2H2-type Nairo_nucleo PF02477.15 EDN11276.1 - 0.092 11.6 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Nucleocapsid N protein DUF3435 PF11917.8 EDN11277.1 - 1.5e-155 518.3 0.0 1.9e-155 517.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) ArnB_C PF18677.1 EDN11277.1 - 0.014 15.5 2.2 0.03 14.4 2.2 1.5 1 0 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain zf-C3HC4_3 PF13920.6 EDN11278.1 - 0.00025 20.8 10.4 0.00041 20.2 10.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ADIP PF11559.8 EDN11278.1 - 0.0046 17.1 2.4 0.0066 16.6 2.4 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EDN11278.1 - 0.0049 17.1 0.5 0.0059 16.8 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) HAUS-augmin3 PF14932.6 EDN11278.1 - 0.0058 16.2 0.6 0.0081 15.8 0.6 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Interferon PF00143.19 EDN11278.1 - 0.0086 16.3 0.0 0.011 16.0 0.0 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain zf-C3HC4_2 PF13923.6 EDN11278.1 - 0.017 14.9 6.5 0.048 13.5 6.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Lebercilin PF15619.6 EDN11278.1 - 0.019 14.6 4.2 0.019 14.6 4.2 1.4 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease UPF0242 PF06785.11 EDN11278.1 - 0.019 15.1 1.9 0.027 14.6 1.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DegS PF05384.11 EDN11278.1 - 0.019 14.4 2.9 0.028 13.9 2.9 1.2 1 0 0 1 1 1 0 Sensor protein DegS Trimer_CC PF08954.11 EDN11278.1 - 0.021 14.4 3.6 0.045 13.3 3.6 1.5 1 0 0 1 1 1 0 Trimerisation motif zf-C3HC4 PF00097.25 EDN11278.1 - 0.031 14.2 6.3 0.075 12.9 6.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Seryl_tRNA_N PF02403.22 EDN11278.1 - 0.04 14.2 0.5 0.066 13.5 0.3 1.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PspA_IM30 PF04012.12 EDN11278.1 - 0.062 12.9 2.3 0.083 12.5 2.3 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF641 PF04859.12 EDN11278.1 - 0.08 13.3 1.3 0.12 12.7 1.3 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Spc24 PF08286.11 EDN11278.1 - 0.13 12.5 0.8 0.25 11.6 0.8 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4407 PF14362.6 EDN11278.1 - 0.16 11.3 0.1 0.21 10.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_5 PF14634.6 EDN11278.1 - 0.74 9.8 10.2 1.5 8.9 10.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-CSL PF05207.13 EDN11281.1 - 0.017 14.9 0.2 0.018 14.8 0.2 1.2 1 0 0 1 1 1 0 CSL zinc finger Acetyltransf_9 PF13527.7 EDN11281.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Exo_endo_phos_2 PF14529.6 EDN11282.1 - 1.5e-27 95.8 0.1 4.1e-27 94.4 0.1 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase HALZ PF02183.18 EDN11282.1 - 7.9e-05 22.8 0.3 0.00016 21.8 0.3 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper Exo_endo_phos PF03372.23 EDN11282.1 - 0.00044 19.8 0.1 0.00079 19.0 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TSC22 PF01166.18 EDN11282.1 - 0.043 14.1 0.9 0.27 11.6 0.2 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family YabA PF06156.13 EDN11282.1 - 0.072 13.7 0.4 0.21 12.3 0.1 1.9 2 0 0 2 2 2 0 Initiation control protein YabA ATG16 PF08614.11 EDN11282.1 - 0.17 12.1 4.3 0.05 13.8 0.7 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Mod_r PF07200.13 EDN11282.1 - 1.5 8.9 4.4 0.23 11.6 0.3 1.7 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein zf-C2H2_6 PF13912.6 EDN11283.1 - 3e-05 23.9 0.1 0.00011 22.1 0.1 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EDN11283.1 - 0.00013 22.2 0.2 0.00013 22.2 0.2 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDN11283.1 - 0.00033 20.9 1.4 0.00033 20.9 1.4 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDN11283.1 - 0.003 18.3 0.1 0.003 18.3 0.1 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 EDN11283.1 - 0.08 13.2 6.0 0.18 12.1 6.0 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 EDN11283.1 - 5.2 7.6 7.7 0.33 11.4 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type F-box-like PF12937.7 EDN11284.1 - 1e-08 34.9 0.1 2.8e-08 33.5 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN11284.1 - 0.0011 18.8 0.0 0.0024 17.7 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDN11284.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 F-box NusG_II PF07009.11 EDN11286.1 - 0.0036 17.5 0.0 0.0046 17.1 0.0 1.1 1 0 0 1 1 1 1 NusG domain II Methyltransf_23 PF13489.6 EDN11287.1 - 3.4e-15 56.3 0.0 3.4e-15 56.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN11287.1 - 2.5e-07 31.3 0.0 5.8e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11287.1 - 2.1e-05 24.3 0.0 0.0083 15.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDN11287.1 - 0.00071 20.2 0.0 0.0013 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN11287.1 - 0.073 13.8 0.0 1.2 10.0 0.0 2.9 2 1 0 2 2 2 0 Methyltransferase domain Nop14 PF04147.12 EDN11287.1 - 0.093 10.9 47.9 0.13 10.4 47.9 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EDN11287.1 - 1.4 8.3 52.0 1.8 7.9 52.0 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 EDN11287.1 - 3.8 6.7 46.4 5.5 6.2 46.4 1.1 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 EDN11287.1 - 4.9 5.8 15.5 6.3 5.4 15.5 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EDN11287.1 - 6.7 5.8 13.7 9 5.4 13.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Pkinase_fungal PF17667.1 EDN11291.1 - 8e-144 479.4 0.0 9.7e-144 479.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EDN11291.1 - 2.7e-07 30.2 0.0 4.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN11291.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EDN11291.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Myb_DNA-binding PF00249.31 EDN11292.1 - 0.0025 18.0 0.0 0.0047 17.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDN11292.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain LSM PF01423.22 EDN11293.1 - 8.5e-06 25.4 0.0 1.4e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDN11293.1 - 0.00052 20.1 0.0 0.00066 19.8 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain RNase_H PF00075.24 EDN11297.1 - 2.3e-12 47.3 0.0 4.7e-12 46.3 0.0 1.5 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EDN11297.1 - 0.15 11.9 0.1 0.5 10.2 0.1 1.9 1 1 0 1 1 1 0 Reverse transcriptase-like Nexin_C PF08628.12 EDN11298.1 - 0.0039 17.7 0.6 0.0042 17.6 0.6 1.0 1 0 0 1 1 1 1 Sorting nexin C terminal Ala_racemase_N PF01168.20 EDN11299.1 - 0.00018 21.2 0.0 0.00055 19.6 0.0 1.7 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.20 EDN11300.1 - 1.4e-126 423.1 4.7 1.8e-126 422.8 4.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EDN11300.1 - 2.5e-44 150.1 0.0 5.7e-44 148.9 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EDN11300.1 - 3.1e-19 69.3 0.1 6.9e-19 68.2 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EDN11300.1 - 9.6e-05 22.5 0.4 0.018 15.1 0.0 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EDN11300.1 - 0.094 12.9 0.7 0.74 10.0 0.1 2.8 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Homeodomain PF00046.29 EDN11302.1 - 5e-12 45.5 2.3 1.1e-11 44.4 2.3 1.6 1 0 0 1 1 1 1 Homeodomain efThoc1 PF11957.8 EDN11303.1 - 2.5e-149 498.1 5.6 3.7e-149 497.5 5.6 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor DUF3275 PF11679.8 EDN11303.1 - 0.24 11.4 0.0 0.24 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) Aquarius_N PF16399.5 EDN11304.1 - 0 1080.2 0.9 0 1079.7 0.9 1.2 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EDN11304.1 - 1.1e-25 90.4 0.0 2.1e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDN11304.1 - 1.6e-20 74.0 0.0 9.2e-20 71.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDN11304.1 - 8.4e-07 28.9 0.0 0.00065 19.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 EDN11304.1 - 1.9e-06 28.0 0.0 4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDN11304.1 - 1.5e-05 25.4 0.0 3.3e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDN11304.1 - 0.0015 18.3 0.2 0.16 11.6 0.1 3.1 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase DnaB_C PF03796.15 EDN11304.1 - 0.0022 17.4 0.0 0.0045 16.4 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA PF00004.29 EDN11304.1 - 0.0059 17.0 0.0 0.018 15.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDN11304.1 - 0.0072 16.7 0.0 0.025 15.0 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EDN11304.1 - 0.033 13.4 0.7 0.072 12.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 EDN11304.1 - 0.034 13.7 0.0 0.087 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 EDN11304.1 - 0.035 13.6 0.0 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 EDN11304.1 - 0.041 13.7 0.3 0.1 12.5 0.3 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain RNA_helicase PF00910.22 EDN11304.1 - 0.052 13.9 0.1 0.91 9.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase DEAD PF00270.29 EDN11304.1 - 0.056 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EDN11304.1 - 0.06 13.6 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 EDN11304.1 - 0.065 12.0 0.1 0.13 11.1 0.1 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_5 PF07728.14 EDN11304.1 - 0.072 13.1 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Parvo_NS1 PF01057.17 EDN11304.1 - 0.08 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 EDN11304.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 EDN11304.1 - 0.18 11.3 0.0 0.4 10.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PIF1 PF05970.14 EDN11304.1 - 0.21 10.7 0.0 10 5.2 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase 4HBT PF03061.22 EDN11305.1 - 7e-14 51.9 0.0 1e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EDN11305.1 - 0.029 14.5 0.0 0.047 13.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4442) Tfb2 PF03849.14 EDN11306.1 - 1.2e-126 422.5 3.9 6.9e-107 357.5 1.4 2.0 1 1 1 2 2 2 2 Transcription factor Tfb2 Tfb2_C PF18307.1 EDN11306.1 - 3.5e-16 59.4 0.0 1e-15 57.9 0.0 1.8 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EDN11306.1 - 2.7e-06 27.6 0.0 8e-05 22.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PhzC-PhzF PF02567.16 EDN11308.1 - 7.7e-38 130.6 0.0 3.8e-37 128.3 0.0 1.8 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein PFL-like PF02901.15 EDN11309.1 - 0.0028 16.4 1.5 0.0028 16.4 1.5 1.4 1 1 0 1 1 1 1 Pyruvate formate lyase-like DUF3746 PF12562.8 EDN11309.1 - 0.0042 17.0 0.8 0.009 15.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3746) HalX PF08663.10 EDN11309.1 - 0.33 11.3 6.8 4.2 7.8 0.4 2.7 2 1 1 3 3 3 0 HalX domain DUF4113 PF13438.6 EDN11311.1 - 0.0056 16.7 0.1 0.0085 16.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4113) IBR PF01485.21 EDN11312.1 - 1.1e-13 51.2 37.7 1.2e-07 31.8 6.6 3.6 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EDN11312.1 - 0.0041 17.0 9.9 0.0041 17.0 9.9 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDN11312.1 - 0.0054 16.5 4.6 0.0054 16.5 4.6 4.3 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDN11312.1 - 6.2 7.1 26.6 0.12 12.5 4.4 3.9 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Toxin_35 PF10530.9 EDN11313.1 - 0.037 14.0 0.0 0.037 14.0 0.0 1.1 1 0 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold RNase_H PF00075.24 EDN11314.1 - 1.2e-07 32.0 0.0 1.9e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 RNase H NYD-SP28 PF14772.6 EDN11315.1 - 0.27 11.3 5.7 0.35 10.9 4.8 1.7 1 1 1 2 2 2 0 Sperm tail RVT_1 PF00078.27 EDN11316.1 - 2.9e-29 102.2 0.0 4.9e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN11316.1 - 1.7e-13 50.4 0.0 5.7e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDN11316.1 - 0.00023 20.8 0.1 0.00048 19.7 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 EDN11316.1 - 4.2 7.6 8.7 1.5 9.0 4.8 2.3 2 0 0 2 2 2 0 Zinc knuckle Nexin_C PF08628.12 EDN11318.1 - 0.014 15.9 0.3 0.022 15.4 0.3 1.2 1 0 0 1 1 1 0 Sorting nexin C terminal DUF4604 PF15377.6 EDN11319.1 - 0.29 11.5 5.6 0.53 10.7 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Na_trans_assoc PF06512.13 EDN11319.1 - 0.47 10.7 4.4 11 6.2 3.3 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated Ribosomal_S17_N PF16205.5 EDN11320.1 - 8.7e-35 118.9 1.0 1.6e-34 118.1 1.0 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EDN11320.1 - 3.2e-27 94.4 0.6 3.2e-27 94.4 0.6 1.6 2 0 0 2 2 2 1 Ribosomal protein S17 Spc7_N PF15402.6 EDN11321.1 - 0 1254.6 56.0 0 1254.6 56.0 1.8 2 0 0 2 2 2 1 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 EDN11321.1 - 1.2e-125 418.5 2.7 2.5e-125 417.5 2.7 1.5 1 0 0 1 1 1 1 Spc7 kinetochore protein MFS_1 PF07690.16 EDN11322.1 - 2e-44 152.0 22.6 2e-44 152.0 22.6 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Pil1 PF13805.6 EDN11323.1 - 2.7e-129 430.3 0.3 3.6e-129 429.9 0.3 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.11 EDN11323.1 - 0.11 11.9 1.7 0.16 11.3 0.8 1.7 1 1 1 2 2 2 0 FAM92 protein SUR7 PF06687.12 EDN11324.1 - 4.1e-50 170.3 3.2 5e-50 170.1 3.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family STE2 PF02116.15 EDN11324.1 - 0.19 11.0 7.6 0.34 10.2 7.6 1.3 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR Ank_2 PF12796.7 EDN11325.1 - 6.2e-46 154.9 0.1 1.2e-14 54.7 0.1 5.9 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDN11325.1 - 6.9e-31 102.8 0.4 0.0081 16.6 0.0 10.2 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 EDN11325.1 - 6.1e-30 102.9 3.1 3.5e-08 33.6 0.1 6.3 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDN11325.1 - 8.6e-29 99.6 0.2 2.1e-07 31.4 0.0 6.6 2 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EDN11325.1 - 2.7e-20 71.8 0.2 0.0064 16.9 0.0 8.1 8 0 0 8 8 8 5 Ankyrin repeat TPP1 PF10341.9 EDN11326.1 - 1.2e-17 63.9 0.0 3.7e-17 62.3 0.0 1.9 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Cpn60_TCP1 PF00118.24 EDN11327.1 - 8.9e-30 103.8 0.0 1.5e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PIP5K PF01504.18 EDN11327.1 - 4.9e-29 101.4 8.9 7.8e-27 94.2 0.5 3.5 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase PK PF00224.21 EDN11328.1 - 2.8e-158 526.3 5.0 3.8e-158 525.9 5.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EDN11328.1 - 1.4e-36 125.2 0.0 4.7e-36 123.6 0.0 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EDN11328.1 - 5.9e-05 22.3 0.8 0.00014 21.1 0.8 1.6 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Ribosomal_S8 PF00410.19 EDN11329.1 - 2.3e-09 37.2 0.0 1.6e-08 34.6 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S8 Iso_dh PF00180.20 EDN11332.1 - 1e-94 317.5 0.0 1.4e-93 313.8 0.0 1.9 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CHASE3 PF05227.13 EDN11332.1 - 0.083 12.8 0.2 0.16 11.9 0.2 1.4 1 0 0 1 1 1 0 CHASE3 domain ICMT PF04140.14 EDN11332.1 - 0.16 12.4 0.0 0.27 11.7 0.0 1.3 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1769 PF08588.10 EDN11333.1 - 3.1e-27 94.5 0.1 9.2e-27 93.0 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) Surfac_D-trimer PF09006.11 EDN11334.1 - 1.3 9.0 3.8 3 7.8 0.0 3.3 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation GRDP-like PF07173.12 EDN11334.1 - 3.5 8.3 12.3 0.046 14.4 1.1 3.1 3 0 0 3 3 3 0 Glycine-rich domain-containing protein-like Baculo_PEP_C PF04513.12 EDN11334.1 - 8 6.5 15.5 0.11 12.5 4.6 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ECH_1 PF00378.20 EDN11336.1 - 1.2e-19 70.6 0.0 1.4e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDN11336.1 - 8.6e-05 22.2 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EDN11336.1 - 0.058 13.3 0.0 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 DUF3506 PF12014.8 EDN11337.1 - 2.4e-49 166.9 0.0 5.9e-49 165.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 EDN11337.1 - 5e-07 29.5 0.4 1.1e-06 28.4 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDN11337.1 - 0.00011 22.0 0.5 0.00022 21.0 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDN11337.1 - 0.11 12.4 0.1 0.3 11.0 0.1 1.7 1 0 0 1 1 1 0 F-box FAD_binding_3 PF01494.19 EDN11339.1 - 4.9e-17 62.2 0.0 4.9e-16 58.9 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EDN11339.1 - 0.00036 19.9 0.0 0.00065 19.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN11339.1 - 0.0039 17.4 0.0 0.0099 16.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDN11339.1 - 0.01 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDN11339.1 - 0.017 15.7 0.0 0.12 12.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDN11339.1 - 0.025 13.3 0.0 0.038 12.7 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EDN11339.1 - 0.058 12.7 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SE PF08491.10 EDN11339.1 - 0.098 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase FAD_oxidored PF12831.7 EDN11339.1 - 0.14 11.5 0.5 1.5 8.1 0.1 2.4 3 0 0 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 EDN11339.1 - 0.18 10.9 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Peptidase_M24 PF00557.24 EDN11340.1 - 1.3e-48 165.5 0.0 1.6e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EDN11340.1 - 1.6e-18 66.7 6.0 3e-18 65.8 6.0 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EDN11340.1 - 0.0018 18.3 3.7 0.0018 18.3 3.7 2.2 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EDN11340.1 - 0.67 9.9 3.7 1.7 8.6 3.7 1.8 1 0 0 1 1 1 0 HIT zinc finger MFS_1 PF07690.16 EDN11341.1 - 7.1e-37 127.1 42.8 3.3e-36 124.9 41.4 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDN11341.1 - 2.3e-13 49.9 7.3 2.3e-13 49.9 7.3 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter ZZ PF00569.17 EDN11342.1 - 5.4e-12 45.3 4.2 9e-12 44.6 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_1 PF00036.32 EDN11342.1 - 5e-11 41.3 5.8 7.5e-05 22.0 0.5 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EDN11342.1 - 1.5e-08 33.9 3.6 0.00077 19.2 0.2 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EDN11342.1 - 1.2e-07 32.0 2.8 8.2e-07 29.4 2.4 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EDN11342.1 - 0.00064 19.5 4.7 0.057 13.3 0.4 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EDN11342.1 - 0.00097 18.5 2.8 0.069 12.7 0.2 2.7 2 0 0 2 2 2 2 EF hand C1_2 PF03107.16 EDN11342.1 - 0.0075 16.6 3.8 0.014 15.7 3.8 1.4 1 0 0 1 1 1 1 C1 domain SUIM_assoc PF16619.5 EDN11342.1 - 1.4 9.1 14.6 0.33 11.1 9.4 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 EDN11343.1 - 2e-32 110.7 9.9 1.4e-08 35.2 0.1 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN11343.1 - 1.2e-13 51.1 0.0 0.00079 19.7 0.0 4.7 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDN11343.1 - 0.3 10.0 1.9 22 3.9 0.0 3.5 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cornichon PF03311.14 EDN11344.1 - 1.3e-43 148.2 14.6 1.5e-43 148.0 14.6 1.0 1 0 0 1 1 1 1 Cornichon protein MFS_1 PF07690.16 EDN11345.1 - 2e-08 33.6 2.9 2.7e-08 33.1 2.8 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Myc_target_1 PF15179.6 EDN11345.1 - 0.41 10.5 1.1 0.61 10.0 1.1 1.2 1 0 0 1 1 1 0 Myc target protein 1 NmrA PF05368.13 EDN11347.1 - 1.3e-20 74.0 0.1 1.7e-20 73.6 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDN11347.1 - 5.6e-16 59.0 0.0 8.3e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Ldh_1_N PF00056.23 EDN11347.1 - 0.0096 16.0 0.0 0.13 12.3 0.0 2.5 3 0 0 3 3 3 1 lactate/malate dehydrogenase, NAD binding domain Epimerase PF01370.21 EDN11347.1 - 0.012 15.1 0.1 0.029 13.8 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDN11347.1 - 0.058 12.4 0.5 0.2 10.6 0.5 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ABC2_membrane PF01061.24 EDN11349.1 - 3.3e-37 127.9 20.3 3.3e-37 127.9 20.3 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EDN11349.1 - 1.4e-24 87.1 0.5 2.7e-24 86.2 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EDN11349.1 - 3.1e-05 24.0 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EDN11349.1 - 0.00067 18.9 23.2 0.00067 18.9 23.2 2.3 2 1 1 3 3 3 1 ABC-2 family transporter protein AAA_29 PF13555.6 EDN11349.1 - 0.022 14.5 0.1 0.048 13.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 EDN11349.1 - 0.028 14.5 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDN11349.1 - 0.029 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 EDN11349.1 - 0.04 13.8 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EDN11349.1 - 0.056 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EDN11349.1 - 0.058 13.9 0.0 0.23 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EDN11349.1 - 0.073 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EDN11349.1 - 0.085 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDN11349.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDN11349.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDN11349.1 - 0.19 11.9 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Laminin_EGF PF00053.24 EDN11349.1 - 0.46 10.7 22.8 4.1 7.6 9.2 2.6 1 1 1 2 2 2 0 Laminin EGF domain EGF_2 PF07974.13 EDN11349.1 - 1.9 9.0 25.0 0.63 10.5 13.9 2.9 2 0 0 2 2 2 0 EGF-like domain Aminotran_1_2 PF00155.21 EDN11350.1 - 0.023 13.9 0.0 3.6 6.7 0.0 2.1 1 1 1 2 2 2 0 Aminotransferase class I and II AMP-binding PF00501.28 EDN11351.1 - 1.8e-67 227.8 0.0 2.3e-67 227.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDN11351.1 - 2e-05 25.5 0.1 0.00011 23.0 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Lyase_1 PF00206.20 EDN11352.1 - 7e-89 298.3 0.0 9.2e-89 297.9 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EDN11352.1 - 2.1e-24 86.1 0.0 4.9e-24 84.9 0.0 1.7 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF1451 PF07295.11 EDN11352.1 - 0.16 12.0 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 Zinc-ribbon containing domain CSN7a_helixI PF18392.1 EDN11352.1 - 0.2 11.6 0.0 0.43 10.5 0.0 1.5 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain Sulfatase PF00884.23 EDN11353.1 - 2.3e-09 37.1 0.1 4e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EDN11353.1 - 0.002 17.8 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDN11354.1 - 0.044 13.2 0.0 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 Sulfatase Sipho_Gp37 PF14594.6 EDN11354.1 - 0.18 10.8 0.0 0.26 10.3 0.0 1.1 1 0 0 1 1 1 0 Siphovirus ReqiPepy6 Gp37-like protein DUF2207 PF09972.9 EDN11354.1 - 7.6 5.2 10.4 23 3.6 11.1 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) TMEM43 PF07787.12 EDN11354.1 - 9.1 5.6 6.8 13 5.1 6.8 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 DDE_1 PF03184.19 EDN11355.1 - 7.2e-22 77.9 0.0 1.5e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EDN11355.1 - 0.00017 21.4 0.1 0.00089 19.0 0.0 2.3 2 1 1 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11355.1 - 0.0018 18.3 0.0 0.0069 16.4 0.0 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN11355.1 - 0.03 14.0 0.5 0.03 14.0 0.5 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF3400 PF11880.8 EDN11355.1 - 0.052 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) Borrelia_P83 PF05262.11 EDN11355.1 - 1.7 7.0 20.1 2.8 6.3 20.1 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 EDN11355.1 - 7.6 6.3 13.4 14 5.4 13.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Polyketide_cyc PF03364.20 EDN11358.1 - 3.5e-21 75.8 0.0 5.1e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EDN11358.1 - 0.001 19.4 0.4 0.0099 16.2 0.4 2.1 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sod_Fe_C PF02777.18 EDN11359.1 - 6.6e-17 61.6 0.0 3.2e-07 30.5 0.0 2.4 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain TMEM154 PF15102.6 EDN11360.1 - 0.056 13.3 0.1 0.099 12.5 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family PIG-S PF10510.9 EDN11361.1 - 1e-172 575.6 2.5 1.3e-172 575.3 2.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein FmiP_Thoc5 PF09766.9 EDN11362.1 - 3.3e-30 105.6 10.5 4.9e-30 105.0 10.5 1.3 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 SPATA1_C PF15743.5 EDN11362.1 - 0.0072 16.4 5.7 0.021 14.9 4.1 2.0 2 0 0 2 2 2 1 Spermatogenesis-associated C-terminus Casc1_N PF15927.5 EDN11362.1 - 0.04 13.6 11.8 0.033 13.9 8.7 2.0 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus K-box PF01486.17 EDN11362.1 - 0.19 12.0 0.2 0.19 12.0 0.2 2.6 2 1 1 3 3 3 0 K-box region APG6_N PF17675.1 EDN11362.1 - 0.3 11.6 10.5 4.7 7.7 5.8 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region Flagellin_N PF00669.20 EDN11362.1 - 0.48 10.5 3.0 0.47 10.6 0.6 2.0 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region DDE_Tnp_ISL3 PF01610.17 EDN11362.1 - 0.53 10.0 4.3 0.18 11.5 1.5 1.6 2 0 0 2 2 2 0 Transposase Mod_r PF07200.13 EDN11362.1 - 0.64 10.1 10.4 0.89 9.6 4.7 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF349 PF03993.12 EDN11362.1 - 0.9 9.9 10.2 0.36 11.2 7.1 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) YabA PF06156.13 EDN11362.1 - 1.6 9.4 6.3 9.7 6.9 1.9 2.2 2 0 0 2 2 2 0 Initiation control protein YabA DUF4140 PF13600.6 EDN11362.1 - 2.4 8.6 7.7 11 6.5 0.1 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) HlyIII PF03006.20 EDN11363.1 - 4.9e-60 203.0 18.3 6e-60 202.7 18.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related Asr PF06392.11 EDN11363.1 - 0.075 13.4 1.7 0.16 12.4 1.7 1.5 1 0 0 1 1 1 0 Acid shock protein repeat SPC12 PF06645.13 EDN11363.1 - 0.17 12.0 3.3 0.15 12.2 1.0 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) YfhO PF09586.10 EDN11363.1 - 2.7 6.1 12.0 3.6 5.7 12.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Fungal_trans PF04082.18 EDN11364.1 - 9.9e-28 96.9 0.4 1.6e-27 96.2 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gal4_dimer PF03902.13 EDN11364.1 - 0.0031 17.7 0.1 0.0068 16.6 0.1 1.6 1 0 0 1 1 1 1 Gal4-like dimerisation domain Sugar_tr PF00083.24 EDN11365.1 - 2.8e-91 306.6 21.8 7.1e-91 305.3 21.8 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDN11365.1 - 6.1e-17 61.6 46.8 4.5e-12 45.6 17.2 2.6 1 1 0 2 2 2 2 Major Facilitator Superfamily Methyltransf_12 PF08242.12 EDN11366.1 - 1.9e-15 57.4 0.0 5.1e-15 56.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDN11366.1 - 4.6e-13 49.7 0.0 8.7e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN11366.1 - 7.5e-11 42.5 0.0 1.4e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN11366.1 - 1.2e-09 38.2 0.0 1.7e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11366.1 - 8.6e-08 32.1 0.0 1.3e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EDN11366.1 - 6.1e-05 24.0 0.0 0.00015 22.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDN11366.1 - 0.00011 21.5 0.0 0.00027 20.2 0.0 1.6 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family Ubie_methyltran PF01209.18 EDN11366.1 - 0.00011 21.6 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EDN11366.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DUF938 PF06080.12 EDN11366.1 - 0.025 14.3 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_28 PF02636.17 EDN11366.1 - 0.11 12.1 0.0 7.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Diphthamide_syn PF01866.17 EDN11368.1 - 1.1e-83 281.1 0.0 6.8e-83 278.6 0.0 1.9 1 1 0 1 1 1 1 Putative diphthamide synthesis protein DDE_1 PF03184.19 EDN11369.1 - 6.9e-30 104.0 0.0 1.3e-29 103.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11369.1 - 1.7e-07 31.1 0.0 4.5e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN11369.1 - 4.8e-07 29.4 0.0 9.9e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN11369.1 - 0.0031 17.3 0.0 0.0064 16.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.6 EDN11369.1 - 0.085 13.0 0.3 0.37 11.0 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain ANAPC4_WD40 PF12894.7 EDN11370.1 - 3.1e-05 24.2 0.0 0.19 12.1 0.0 2.8 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain SPT6_acidic PF14632.6 EDN11370.1 - 0.02 15.5 12.3 0.043 14.4 12.3 1.5 1 0 0 1 1 1 0 Acidic N-terminal SPT6 RAB3GAP2_N PF14655.6 EDN11370.1 - 0.025 13.9 0.0 3.1 7.0 0.0 2.6 2 1 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus p450 PF00067.22 EDN11371.1 - 1.8e-50 172.1 0.0 2.2e-50 171.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BIV_Env PF05858.12 EDN11371.1 - 0.012 13.8 0.0 1.2 7.2 0.0 2.1 2 0 0 2 2 2 0 Bovine immunodeficiency virus surface protein (SU) DIE2_ALG10 PF04922.12 EDN11372.1 - 2.6e-122 408.9 13.2 3.5e-122 408.5 13.2 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family Sld5 PF05916.11 EDN11373.1 - 1.3e-34 118.9 0.0 2.2e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein CUE PF02845.16 EDN11374.1 - 1.3e-11 43.9 0.0 2.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 EDN11374.1 - 0.013 15.1 10.5 0.025 14.2 10.5 1.4 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) Methyltransf_25 PF13649.6 EDN11375.1 - 2.6e-09 37.7 0.0 4.9e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDN11375.1 - 1.1e-07 32.5 0.0 2.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDN11375.1 - 1.2e-06 28.5 0.0 1.8e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDN11375.1 - 5.9e-06 26.2 0.0 1.6e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDN11375.1 - 0.00012 22.7 0.0 0.00023 21.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EDN11375.1 - 0.00028 20.4 0.0 0.00045 19.8 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain SMC_N PF02463.19 EDN11376.1 - 4.8e-70 235.4 1.4 1.4e-69 233.9 1.4 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDN11376.1 - 6.3e-22 78.1 0.9 3.1e-21 75.8 0.2 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EDN11376.1 - 2.5e-09 37.9 15.3 2.5e-09 37.9 15.3 6.8 2 2 2 5 5 5 1 AAA domain AAA_21 PF13304.6 EDN11376.1 - 4e-09 36.7 11.9 0.00034 20.5 0.0 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MscS_porin PF12795.7 EDN11376.1 - 0.00036 20.1 18.7 0.00036 20.1 18.7 6.8 2 2 5 7 7 7 2 Mechanosensitive ion channel porin domain AAA_29 PF13555.6 EDN11376.1 - 0.00096 18.8 0.1 0.0023 17.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain HIP1_clath_bdg PF16515.5 EDN11376.1 - 0.0024 18.5 11.8 0.0024 18.5 11.8 9.6 3 2 7 10 10 10 2 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF745 PF05335.13 EDN11376.1 - 0.0082 15.9 16.6 0.0082 15.9 16.6 5.5 3 1 1 5 5 5 1 Protein of unknown function (DUF745) ABC_tran PF00005.27 EDN11376.1 - 0.073 13.6 0.1 0.073 13.6 0.1 5.4 4 2 0 4 4 4 0 ABC transporter Val_tRNA-synt_C PF10458.9 EDN11376.1 - 0.48 10.7 0.0 0.48 10.7 0.0 9.1 8 1 1 9 9 9 0 Valyl tRNA synthetase tRNA binding arm GDI PF00996.18 EDN11377.1 - 8.5e-187 621.0 0.0 1.1e-186 620.6 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Pyr_redox PF00070.27 EDN11377.1 - 0.048 14.2 0.2 1 10.0 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDN11377.1 - 0.097 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain MRP-L47 PF06984.13 EDN11378.1 - 5.9e-21 74.4 0.0 8.9e-21 73.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NOT2_3_5 PF04153.18 EDN11380.1 - 9.2e-27 93.7 1.4 1.5e-26 93.1 0.0 1.9 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family 4HBT PF03061.22 EDN11381.1 - 1.6e-10 41.1 0.3 2.3e-10 40.7 0.3 1.2 1 0 0 1 1 1 1 Thioesterase superfamily ORC4_C PF14629.6 EDN11383.1 - 8.5e-52 175.7 0.0 1.3e-51 175.0 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EDN11383.1 - 1.2e-15 58.3 0.1 2.9e-15 57.1 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDN11383.1 - 3.5e-07 30.7 0.0 1.4e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDN11383.1 - 2.3e-05 24.7 0.0 7e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EDN11383.1 - 6.8e-05 22.2 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NACHT PF05729.12 EDN11383.1 - 0.00033 20.6 0.0 0.0014 18.6 0.0 2.1 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 EDN11383.1 - 0.00088 19.3 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EDN11383.1 - 0.0076 16.6 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EDN11383.1 - 0.05 13.0 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EDN11383.1 - 0.069 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EDN11383.1 - 0.092 12.8 0.0 0.25 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDN11383.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain RGS PF00615.19 EDN11385.1 - 1.5e-32 112.4 0.0 3.1e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 EDN11385.1 - 2.8e-24 84.9 0.0 1.4e-21 76.3 0.0 2.4 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CDC73_C PF05179.14 EDN11386.1 - 1.6e-56 190.3 0.0 4.6e-55 185.6 0.0 2.1 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal TOM6p PF15184.6 EDN11386.1 - 0.12 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog HNH_2 PF13391.6 EDN11387.1 - 1.9e-05 24.7 0.0 3.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease UFC1 PF08694.11 EDN11387.1 - 0.22 11.1 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 SET PF00856.28 EDN11388.1 - 1.2e-07 32.3 0.5 1.5e-05 25.5 0.0 2.9 3 0 0 3 3 3 2 SET domain PHD PF00628.29 EDN11388.1 - 0.00012 21.9 10.0 0.00027 20.8 10.0 1.6 1 0 0 1 1 1 1 PHD-finger ArfGap PF01412.18 EDN11389.1 - 8.6e-07 29.0 0.0 1.9e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Glyco_transf_22 PF03901.17 EDN11390.1 - 1.5e-76 258.3 23.8 2.1e-76 257.9 23.8 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Aminotran_3 PF00202.21 EDN11391.1 - 9.1e-116 386.8 0.0 1.1e-115 386.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III OAM_dimer PF16554.5 EDN11391.1 - 0.05 14.1 0.5 0.12 12.9 0.0 1.8 2 0 0 2 2 2 0 Dimerisation domain of d-ornithine 4,5-aminomutase Aminotran_1_2 PF00155.21 EDN11391.1 - 0.051 12.8 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Aminotransferase class I and II ABC_membrane PF00664.23 EDN11392.1 - 8.2e-55 186.4 37.6 6.3e-33 114.6 18.8 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EDN11392.1 - 1.8e-45 154.8 0.1 6.4e-26 91.5 0.0 3.3 3 0 0 3 3 2 2 ABC transporter MMR_HSR1 PF01926.23 EDN11392.1 - 1e-06 28.8 0.1 0.051 13.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EDN11392.1 - 1.6e-05 24.3 0.0 0.0045 16.3 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 EDN11392.1 - 1.8e-05 24.7 0.3 0.037 13.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EDN11392.1 - 5.2e-05 22.8 2.2 0.2 11.1 0.9 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDN11392.1 - 0.00018 21.2 1.3 0.71 9.7 0.5 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDN11392.1 - 0.00022 21.7 0.0 0.41 11.0 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 EDN11392.1 - 0.00023 21.3 0.8 0.0036 17.4 0.1 2.5 2 0 0 2 2 2 1 Dynamin family AAA_18 PF13238.6 EDN11392.1 - 0.00068 20.2 0.0 1.4 9.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 EDN11392.1 - 0.0035 17.5 3.5 0.012 15.7 0.3 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain MeaB PF03308.16 EDN11392.1 - 0.0044 16.1 1.3 1.8 7.5 0.1 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EDN11392.1 - 0.011 15.1 0.2 0.22 10.8 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_15 PF13175.6 EDN11392.1 - 0.013 15.2 0.1 0.99 9.0 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EDN11392.1 - 0.019 15.5 4.3 3 8.3 0.4 2.8 3 0 0 3 3 2 0 AAA domain AAA_21 PF13304.6 EDN11392.1 - 0.024 14.4 2.0 4.3 7.0 0.1 3.1 3 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDN11392.1 - 0.026 14.8 7.3 3.8 7.8 1.3 3.7 3 1 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EDN11392.1 - 0.031 14.7 0.1 10 6.6 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 EDN11392.1 - 0.06 12.9 1.1 4.3 6.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 EDN11392.1 - 0.071 12.9 1.5 2.9 7.6 0.1 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 EDN11392.1 - 0.086 13.3 0.1 0.94 9.9 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EDN11392.1 - 0.096 11.9 2.5 1.1 8.4 0.4 2.6 2 0 0 2 2 2 0 NB-ARC domain TrwB_AAD_bind PF10412.9 EDN11392.1 - 0.12 11.3 1.8 3.6 6.4 0.7 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.6 EDN11392.1 - 0.23 11.7 0.0 0.23 11.7 0.0 2.7 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 EDN11392.1 - 0.3 11.1 0.8 17 5.5 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE dNK PF01712.19 EDN11392.1 - 0.76 9.6 2.0 9.2 6.1 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_7 PF12775.7 EDN11392.1 - 0.99 8.9 2.7 8.2 5.9 0.2 2.5 3 0 0 3 3 3 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 EDN11392.1 - 1.9 8.0 4.4 28 4.2 0.3 3.2 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Oleosin PF01277.17 EDN11392.1 - 2.9 7.7 5.9 0.66 9.8 0.2 2.8 3 0 0 3 3 3 0 Oleosin DUF3435 PF11917.8 EDN11393.1 - 4e-155 516.8 0.1 4e-155 516.8 0.1 1.4 2 0 0 2 2 1 1 Protein of unknown function (DUF3435) MRNIP PF15749.5 EDN11393.1 - 0.031 15.0 6.2 2.7 8.8 3.2 2.5 2 0 0 2 2 2 0 MRN-interacting protein Vfa1 PF08432.10 EDN11393.1 - 0.063 13.6 6.1 0.18 12.1 6.1 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pox_Ag35 PF03286.14 EDN11393.1 - 0.064 13.0 12.1 0.12 12.1 12.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BSP_II PF05432.11 EDN11393.1 - 0.09 12.5 19.3 0.14 11.8 19.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CotH PF08757.11 EDN11393.1 - 0.2 11.1 6.6 0.42 10.1 6.6 1.5 1 0 0 1 1 1 0 CotH kinase protein Ribosomal_L6e PF01159.19 EDN11393.1 - 0.28 11.7 3.7 0.99 10.0 3.7 1.9 1 0 0 1 1 1 0 Ribosomal protein L6e CPSF100_C PF13299.6 EDN11393.1 - 0.3 11.3 6.5 0.6 10.3 6.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1943 PF09172.11 EDN11393.1 - 0.3 10.3 1.5 0.49 9.6 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Nop14 PF04147.12 EDN11393.1 - 0.5 8.5 18.5 0.97 7.6 18.5 1.4 1 0 0 1 1 1 0 Nop14-like family POX PF07526.11 EDN11393.1 - 0.68 10.5 3.5 1.8 9.1 3.5 1.6 1 0 0 1 1 1 0 Associated with HOX SDA1 PF05285.12 EDN11393.1 - 1.1 8.6 20.0 1.8 7.9 20.0 1.2 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 EDN11393.1 - 1.3 8.9 10.4 2.6 7.9 10.4 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RRN3 PF05327.11 EDN11393.1 - 1.5 7.3 8.0 2.6 6.5 8.0 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SpoIIIAH PF12685.7 EDN11393.1 - 1.8 8.4 9.7 2.9 7.7 9.7 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein CDC45 PF02724.14 EDN11393.1 - 1.9 6.7 11.1 2.8 6.1 11.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Radial_spoke PF04712.12 EDN11393.1 - 5.4 5.9 15.2 8.8 5.1 15.2 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein PPL5 PF18168.1 EDN11393.1 - 5.5 6.2 8.5 10 5.3 8.5 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF2428 PF10350.9 EDN11393.1 - 6.3 6.0 7.5 15 4.8 7.5 1.6 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) MscS_TM PF12794.7 EDN11393.1 - 6.5 5.5 5.9 10 4.8 5.9 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Adaptin_binding PF10199.9 EDN11393.1 - 7.6 7.2 15.4 2.4 8.8 12.0 1.8 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Pkinase PF00069.25 EDN11395.1 - 1.7e-12 47.3 1.7 2.5e-12 46.7 1.7 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDN11395.1 - 2e-07 30.6 2.4 2.9e-07 30.0 2.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HNH_2 PF13391.6 EDN11397.1 - 1.5e-17 63.4 0.1 4.5e-17 61.9 0.1 1.9 1 0 0 1 1 1 1 HNH endonuclease APH PF01636.23 EDN11397.1 - 2.5e-07 30.9 0.1 1e-06 28.9 0.1 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family KNOX2 PF03791.13 EDN11397.1 - 0.074 12.6 0.2 0.18 11.3 0.2 1.6 1 0 0 1 1 1 0 KNOX2 domain DUF3696 PF12476.8 EDN11400.1 - 0.74 10.3 3.1 2.5 8.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3696) Pkinase PF00069.25 EDN11401.1 - 7.3e-07 28.8 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDN11401.1 - 3.7e-05 23.2 0.0 6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDN11401.1 - 0.00053 20.0 0.2 0.0017 18.3 0.2 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDN11401.1 - 0.0055 16.3 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase ADP_ribosyl_GH PF03747.14 EDN11402.1 - 8.8e-50 170.1 0.0 1.6e-49 169.2 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase SHR3_chaperone PF08229.11 EDN11405.1 - 7.3e-80 266.4 0.0 8.6e-80 266.2 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF5453 PF17534.2 EDN11405.1 - 0.69 9.8 2.6 0.44 10.5 0.3 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5453) Tyrosinase PF00264.20 EDN11406.1 - 2.6e-54 184.8 0.7 4.1e-54 184.2 0.7 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EDN11406.1 - 1.6e-19 70.7 0.0 2.8e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Gal-bind_lectin PF00337.22 EDN11406.1 - 8.9e-06 25.3 0.0 1.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Galactoside-binding lectin Arrestin_N PF00339.29 EDN11407.1 - 4.7e-15 55.9 0.0 1.2e-14 54.6 0.0 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EDN11407.1 - 0.00015 22.2 0.1 0.00077 19.9 0.0 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain U-box PF04564.15 EDN11407.1 - 0.15 12.3 0.7 0.47 10.7 0.1 2.2 2 1 0 2 2 2 0 U-box domain Flavoprotein PF02441.19 EDN11409.1 - 2.3e-46 157.5 0.0 2.6e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein Mnd1 PF03962.15 EDN11411.1 - 2.7e-23 82.0 0.5 6e-23 80.9 0.0 1.8 2 0 0 2 2 2 1 Mnd1 HTH domain DsrD PF08679.11 EDN11411.1 - 0.00055 20.1 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Dissimilatory sulfite reductase D (DsrD) LZ3wCH PF18517.1 EDN11411.1 - 0.0016 18.5 0.4 0.0058 16.7 0.4 1.9 1 0 0 1 1 1 1 Leucine zipper with capping helix domain Penicillinase_R PF03965.16 EDN11411.1 - 0.013 15.9 0.2 0.023 15.1 0.2 1.4 1 0 0 1 1 1 0 Penicillinase repressor UAF_Rrn10 PF05234.11 EDN11412.1 - 0.00015 22.0 0.0 0.00024 21.4 0.0 1.3 1 0 0 1 1 1 1 UAF complex subunit Rrn10 DDE_1 PF03184.19 EDN11413.1 - 4.3e-30 104.7 0.0 2.3e-29 102.3 0.0 2.2 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11413.1 - 2e-07 30.9 0.0 6.6e-07 29.3 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EDN11413.1 - 7.1e-07 28.9 0.0 1.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EDN11413.1 - 0.00082 19.1 0.0 0.0093 15.7 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EDN11413.1 - 0.0019 17.9 9.8 0.0035 17.0 1.7 2.4 2 0 0 2 2 2 2 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EDN11413.1 - 0.037 13.9 0.4 0.32 10.8 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EDN11413.1 - 0.17 12.1 1.4 0.31 11.2 1.4 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDN11413.1 - 0.37 10.5 4.0 0.1 12.4 0.5 1.8 2 0 0 2 2 2 0 Zinc knuckle DUF2407_C PF13373.6 EDN11414.1 - 0.56 10.4 6.6 0.68 10.1 6.6 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain AIF_C PF14721.6 EDN11414.1 - 7 7.0 7.6 77 3.6 7.6 2.0 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HTH_psq PF05225.16 EDN11415.1 - 0.0072 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 EDN11415.1 - 0.059 13.4 0.0 0.45 10.6 0.0 2.2 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 EDN11415.1 - 0.099 12.5 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain WD40 PF00400.32 EDN11416.1 - 3.4e-16 59.3 15.3 0.00016 22.4 0.6 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDN11416.1 - 1.6e-08 34.7 0.0 0.21 11.9 0.0 4.6 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4219 PF13961.6 EDN11417.1 - 0.045 13.4 0.1 0.066 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Retrotran_gag_3 PF14244.6 EDN11417.1 - 0.046 13.5 0.0 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Chromo PF00385.24 EDN11418.1 - 1.2e-13 50.8 0.2 3.5e-13 49.2 0.2 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 EDN11418.1 - 0.0064 16.4 0.2 0.016 15.1 0.2 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain RVT_1 PF00078.27 EDN11420.1 - 1.9e-33 115.8 0.0 3.1e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EDN11420.1 - 2.9e-12 46.5 0.0 8.5e-12 45.0 0.0 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EDN11420.1 - 9.4e-12 45.3 0.0 2e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 RNase H Nexin_C PF08628.12 EDN11421.1 - 0.0051 17.4 0.3 0.0071 16.9 0.3 1.2 1 0 0 1 1 1 1 Sorting nexin C terminal Pkinase PF00069.25 EDN11424.1 - 8.5e-06 25.3 0.1 2.6e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EDN11424.1 - 2.3e-05 23.9 0.0 5.1e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDN11424.1 - 0.00058 18.8 0.1 0.0011 17.9 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EDN11424.1 - 0.012 15.5 0.0 0.037 13.9 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Muted PF14942.6 EDN11424.1 - 0.072 13.4 0.1 0.18 12.2 0.1 1.6 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein STAT_int PF02865.17 EDN11425.1 - 0.047 14.2 1.4 0.091 13.2 0.2 1.9 1 1 1 2 2 2 0 STAT protein, protein interaction domain NDC10_II PF16787.5 EDN11426.1 - 1.8e-36 125.8 0.0 4e-24 85.2 0.0 2.1 1 1 1 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Sipho_tail PF05709.11 EDN11426.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Phage tail protein Fungal_trans_2 PF11951.8 EDN11427.1 - 1.3e-90 304.0 0.0 1.8e-90 303.6 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDN11427.1 - 0.00015 21.8 9.5 0.0003 20.8 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_pol_phi PF04931.13 EDN11428.1 - 0.0038 15.4 14.0 0.0047 15.1 14.0 1.2 1 0 0 1 1 1 1 DNA polymerase phi CDC45 PF02724.14 EDN11428.1 - 0.0095 14.3 5.7 0.0098 14.2 5.7 1.2 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 EDN11428.1 - 0.017 14.5 7.3 0.02 14.3 7.3 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EDN11428.1 - 0.025 12.8 8.2 0.025 12.8 8.2 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EDN11428.1 - 0.049 12.2 9.4 0.068 11.7 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 EDN11428.1 - 0.071 13.0 8.1 0.098 12.5 8.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Osteopontin PF00865.18 EDN11428.1 - 0.1 12.1 19.3 0.12 11.9 19.3 1.2 1 0 0 1 1 1 0 Osteopontin eIF-3c_N PF05470.12 EDN11428.1 - 0.15 10.4 3.1 0.18 10.1 3.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2457 PF10446.9 EDN11428.1 - 0.6 9.2 28.2 0.93 8.6 28.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Tom22 PF04281.13 EDN11428.1 - 1.2 8.9 7.5 0.075 12.8 1.7 1.9 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 PPP4R2 PF09184.11 EDN11428.1 - 2.3 7.8 11.6 3.6 7.1 11.6 1.4 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 EDN11428.1 - 2.3 7.5 12.3 0.079 12.3 6.9 1.3 2 0 0 2 2 2 0 BUD22 FAM176 PF14851.6 EDN11428.1 - 2.6 7.7 8.3 0.73 9.5 5.0 1.8 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 EDN11428.1 - 5.6 7.0 13.5 1.7 8.7 10.3 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal NOA36 PF06524.12 EDN11428.1 - 6.5 6.0 28.1 0.68 9.2 23.9 1.4 2 0 0 2 2 2 0 NOA36 protein SAM_2 PF07647.17 EDN11430.1 - 1.7e-10 40.8 0.0 3.2e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDN11430.1 - 1.3e-08 35.1 0.0 2.6e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 EDN11430.1 - 4e-07 30.5 0.9 1.5e-06 28.6 0.2 2.4 2 2 1 3 3 3 1 PH domain SAM_3 PF18016.1 EDN11430.1 - 0.0023 17.7 0.0 0.0054 16.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EDN11430.1 - 0.028 14.6 0.0 0.054 13.7 0.0 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif PH_9 PF15410.6 EDN11430.1 - 0.048 14.0 0.4 0.13 12.6 0.4 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain APG5 PF04106.12 EDN11431.1 - 3.1e-66 223.2 0.0 3.9e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 Tyr-DNA_phospho PF06087.12 EDN11432.1 - 2.1e-162 540.9 0.0 2.5e-162 540.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EDN11432.1 - 0.012 15.5 0.0 3.2 7.6 0.0 2.3 2 0 0 2 2 2 0 PLD-like domain QCR10 PF09796.9 EDN11433.1 - 2.7e-27 94.6 0.6 3.8e-27 94.1 0.6 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Chromo PF00385.24 EDN11434.1 - 7.7e-15 54.5 5.4 2e-14 53.2 5.4 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SP2 PF03014.14 EDN11435.1 - 0.054 11.9 0.0 0.055 11.9 0.0 1.0 1 0 0 1 1 1 0 Structural protein 2 Pkinase PF00069.25 EDN11436.1 - 4e-27 95.2 0.0 1.3e-16 60.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDN11436.1 - 1.3e-09 37.7 0.0 7.1e-07 28.8 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EDN11436.1 - 1.4e-05 24.6 0.2 0.035 13.4 0.0 3.1 2 1 0 3 3 3 3 Kinase-like APH PF01636.23 EDN11436.1 - 0.0064 16.4 0.2 0.082 12.8 0.2 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family RVT_2 PF07727.14 EDN11437.1 - 8.5e-44 150.0 0.0 1.2e-43 149.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_1 PF03184.19 EDN11438.1 - 1e-18 67.6 0.0 2.6e-18 66.3 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDN11438.1 - 1.1e-13 50.9 0.1 1.2e-12 47.7 0.0 2.6 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain EST1_DNA_bind PF10373.9 EDN11438.1 - 0.0036 16.8 0.3 0.0076 15.8 0.0 1.6 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain PFL-like PF02901.15 EDN11438.1 - 0.029 13.0 0.7 0.047 12.3 0.7 1.2 1 0 0 1 1 1 0 Pyruvate formate lyase-like Mpp10 PF04006.12 EDN11439.1 - 3.3e-86 290.1 5.2 4.3e-86 289.7 5.2 1.0 1 0 0 1 1 1 1 Mpp10 protein Exo_endo_phos_2 PF14529.6 EDN11443.1 - 2.5e-13 49.9 0.0 1.1e-12 47.8 0.0 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase MethyTransf_Reg PF10119.9 EDN11443.1 - 0.079 13.7 0.1 3.5 8.4 0.0 2.7 2 0 0 2 2 2 0 Predicted methyltransferase regulatory domain RVT_1 PF00078.27 EDN11444.1 - 6.8e-21 74.8 0.0 7.8e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FKS1_dom1 PF14288.6 EDN11444.1 - 0.057 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 OrsD PF12013.8 EDN11446.1 - 1.1e-18 67.7 0.1 1.1e-18 67.7 0.1 2.2 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D Helicase_C PF00271.31 EDN11447.1 - 2e-08 34.5 0.1 5.4e-08 33.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Retrotran_gag_2 PF14223.6 EDN11448.1 - 0.068 12.8 1.8 0.12 12.0 1.8 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type HD_4 PF13328.6 EDN11448.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 HD domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Histoplasma_capsulatum_NAm1-ASM14958v1/GCA_000149585.1_ASM14958v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Histoplasma_capsulatum_NAm1-ASM14958v1/GCA_000149585.1_ASM14958v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Histoplasma_capsulatum_NAm1-ASM14958v1/GCA_000149585.1_ASM14958v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Histoplasma_capsulatum_NAm1-ASM14958v1/GCA_000149585.1_ASM14958v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 21:26:27 2019 # [ok]