# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- WGG PF10273.9 EFW98400.1 - 0.091 13.4 0.0 0.13 13.0 0.0 1.4 1 0 0 1 1 1 0 Pre-rRNA-processing protein TSR2 UQ_con PF00179.26 EFW98401.1 - 6.8e-10 38.7 0.0 1.1e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFW98401.1 - 0.053 13.8 0.1 0.089 13.1 0.1 1.3 1 0 0 1 1 1 0 RWD domain MFS_1 PF07690.16 EFW98402.1 - 1.4e-29 103.2 24.9 1.9e-29 102.7 24.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW98402.1 - 0.00049 19.1 9.8 0.00049 19.1 9.8 2.6 3 1 1 4 4 4 1 Sugar (and other) transporter Mur_ligase_M PF08245.12 EFW98403.1 - 0.043 13.8 0.6 0.53 10.2 0.0 2.4 2 1 0 2 2 2 0 Mur ligase middle domain Molybdopterin PF00384.22 EFW98404.1 - 2.1e-74 251.0 0.0 1.6e-72 244.8 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 EFW98404.1 - 4.3e-20 71.5 0.2 1.1e-19 70.2 0.2 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 EFW98404.1 - 1.7e-18 67.0 0.1 6.6e-18 65.1 0.0 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EFW98404.1 - 2.6e-17 62.1 0.2 2.6e-17 62.1 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 EFW98404.1 - 7.4e-08 32.2 0.6 7.4e-08 32.2 0.6 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 EFW98404.1 - 0.0043 16.8 0.0 0.052 13.3 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 EFW98404.1 - 0.12 12.2 1.1 3.5 7.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 EFW98404.1 - 0.24 11.5 1.6 2.6 8.2 1.6 2.4 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster DIOX_N PF14226.6 EFW98405.1 - 2.5e-26 92.7 0.0 4e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFW98405.1 - 8.4e-19 67.9 0.0 1.5e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 EFW98408.1 - 2.3e-06 27.6 11.0 4.4e-06 26.7 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFW98408.1 - 0.0046 16.0 0.1 0.052 12.6 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain K_channel_TID PF07941.11 EFW98408.1 - 2.8 8.4 12.3 0.67 10.5 5.1 2.9 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain FAD_binding_7 PF03441.14 EFW98409.1 - 1.4e-79 266.3 0.6 3.1e-79 265.2 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EFW98409.1 - 3.3e-39 134.5 0.1 5.9e-39 133.7 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase DUSP PF06337.12 EFW98409.1 - 0.0082 16.7 0.0 0.018 15.7 0.0 1.5 1 0 0 1 1 1 1 DUSP domain PPP4R2 PF09184.11 EFW98411.1 - 0.00021 21.0 16.3 0.00021 21.0 16.3 3.7 2 1 0 2 2 2 1 PPP4R2 K_channel_TID PF07941.11 EFW98411.1 - 0.0077 16.7 5.8 0.0077 16.7 5.8 5.4 6 0 0 6 6 6 1 Potassium channel Kv1.4 tandem inactivation domain Aldo_ket_red PF00248.21 EFW98412.1 - 8.8e-38 130.2 0.1 1.2e-36 126.4 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family HTH_AsnC-type PF13404.6 EFW98412.1 - 0.053 13.4 0.2 0.56 10.1 0.0 2.6 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Ribosomal_L3 PF00297.22 EFW98413.1 - 2e-11 43.5 3.7 2.9e-09 36.4 1.1 2.4 1 1 1 2 2 2 2 Ribosomal protein L3 SMN PF06003.12 EFW98414.1 - 5.7e-05 22.5 0.1 7.3e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) MCRA PF06100.11 EFW98415.1 - 2.9e-151 504.7 0.0 9.2e-125 417.2 0.0 2.2 1 1 0 2 2 2 2 MCRA family NAD_binding_8 PF13450.6 EFW98415.1 - 0.00068 19.8 0.1 0.0028 17.8 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFW98415.1 - 0.0016 18.1 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF406 PF04175.12 EFW98415.1 - 0.064 13.7 0.9 0.15 12.5 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF406) HTH_31 PF13560.6 EFW98416.1 - 0.078 13.3 1.1 0.56 10.6 0.8 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain eIF3g PF12353.8 EFW98417.1 - 8e-40 136.1 1.0 1.3e-39 135.5 1.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EFW98417.1 - 9.7e-17 60.6 0.1 1.6e-16 59.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 EFW98417.1 - 0.026 14.8 0.2 0.047 14.0 0.2 1.3 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Gloverin PF10793.9 EFW98417.1 - 1.4 8.7 7.2 3.6 7.4 6.6 1.9 1 1 1 2 2 2 0 Gloverin-like protein Ribosomal_L19 PF01245.20 EFW98418.1 - 2.4e-12 46.7 0.0 4.2e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 HA2 PF04408.23 EFW98419.1 - 5.6e-17 62.0 0.8 1.2e-16 60.9 0.1 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFW98419.1 - 3.5e-16 59.3 0.0 7e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFW98419.1 - 3.9e-11 43.3 0.0 9.6e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFW98419.1 - 4.9e-05 23.6 0.0 0.00013 22.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EFW98419.1 - 8.6e-05 22.4 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EFW98419.1 - 0.00023 20.9 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFW98419.1 - 0.0028 18.0 0.0 0.0089 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EFW98419.1 - 0.028 14.0 0.3 0.19 11.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EFW98419.1 - 0.51 9.9 2.7 1.3 8.6 0.3 2.8 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain PSD2 PF07624.11 EFW98420.1 - 0.022 14.5 0.0 0.061 13.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) Abhydrolase_6 PF12697.7 EFW98422.1 - 3.5e-10 40.8 0.2 5.3e-10 40.3 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family TRP PF06011.12 EFW98423.1 - 6.4e-40 137.2 23.5 1.1e-31 110.0 17.7 2.2 2 0 0 2 2 2 2 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFW98423.1 - 1.2e-26 93.8 0.8 1.7e-26 93.2 0.8 1.2 1 0 0 1 1 1 1 ML-like domain DUF4381 PF14316.6 EFW98423.1 - 0.44 10.8 4.6 10 6.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) LtrA PF06772.11 EFW98424.1 - 9e-40 137.0 35.3 1.2e-39 136.6 35.3 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF1765 PF08578.10 EFW98424.1 - 0.095 13.2 0.8 3.9 8.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1765) cPLA2_C2 PF18695.1 EFW98424.1 - 0.2 11.7 0.5 1.3 9.1 0.3 2.3 2 1 1 3 3 3 0 Cytosolic phospholipases A2 C2-domain DUF3337 PF11816.8 EFW98425.1 - 2.5e-35 121.9 0.0 9.2e-35 120.0 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EFW98425.1 - 3.6e-17 62.4 10.6 0.00098 19.9 0.1 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW98425.1 - 0.0027 18.0 0.1 1.2 9.5 0.1 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFW98425.1 - 0.3 9.7 7.0 0.049 12.3 0.4 2.8 3 1 1 4 4 4 0 Nucleoporin Nup120/160 Peroxin-13_N PF04088.13 EFW98426.1 - 2.1e-51 174.0 0.0 3.6e-51 173.3 0.0 1.4 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_9 PF14604.6 EFW98426.1 - 8.7e-08 31.9 0.3 1.7e-06 27.8 0.3 2.3 1 1 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFW98426.1 - 9.3e-08 31.6 0.0 1.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFW98426.1 - 1.3e-05 24.7 0.3 0.00049 19.6 0.3 2.3 1 1 0 1 1 1 1 SH3 domain CENP-T_C PF15511.6 EFW98428.1 - 8.7e-46 154.5 0.0 1.5e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFW98428.1 - 1.3e-11 44.7 0.0 2.2e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EFW98428.1 - 8.7e-06 26.1 0.0 2.4e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 zf-CSL PF05207.13 EFW98431.1 - 0.06 13.1 1.9 0.079 12.7 0.3 1.8 2 0 0 2 2 2 0 CSL zinc finger Cys_Met_Meta_PP PF01053.20 EFW98432.1 - 6.1e-153 508.9 0.0 6.9e-153 508.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFW98432.1 - 3.4e-11 43.1 0.1 5.8e-11 42.3 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EFW98432.1 - 9.7e-11 41.4 0.0 2.8e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFW98432.1 - 7e-09 35.1 0.8 3.8e-08 32.7 0.2 2.2 2 1 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFW98432.1 - 1e-06 28.3 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 EFW98432.1 - 0.0033 17.6 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain Met_gamma_lyase PF06838.11 EFW98432.1 - 0.0045 15.6 0.0 0.0058 15.2 0.0 1.1 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.16 EFW98432.1 - 0.0058 15.5 0.0 0.0085 15.0 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein Pyridoxal_deC PF00282.19 EFW98433.1 - 1.8e-13 50.0 0.0 3.2e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EFW98433.1 - 1.3e-07 30.9 0.0 2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFW98433.1 - 7.1e-05 22.3 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Mito_carr PF00153.27 EFW98434.1 - 2.9e-43 145.7 7.9 6.3e-17 61.3 0.0 4.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFW98434.1 - 0.15 11.2 4.1 0.85 8.7 0.1 2.7 2 1 1 3 3 3 0 Gammaproteobacterial serine protease NOT2_3_5 PF04153.18 EFW98435.1 - 6.7e-28 97.4 0.4 1e-27 96.8 0.4 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family JmjC PF02373.22 EFW98437.1 - 2.1e-10 41.0 0.0 5.2e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EFW98437.1 - 5.7e-07 29.7 10.2 5.7e-07 29.7 10.2 2.4 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 EFW98437.1 - 0.025 14.3 0.0 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 Cupin domain AAA PF00004.29 EFW98438.1 - 2.2e-77 257.8 0.0 9e-45 152.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFW98438.1 - 9.5e-18 63.7 1.3 3e-08 33.3 0.0 3.5 3 0 0 3 3 3 2 AAA+ lid domain RuvB_N PF05496.12 EFW98438.1 - 4.2e-16 59.1 0.0 1.7e-08 34.4 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFW98438.1 - 9e-12 45.7 3.5 0.00012 22.5 0.0 4.8 3 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EFW98438.1 - 7.7e-11 42.4 0.2 0.0079 16.5 0.0 4.4 3 2 1 4 4 4 2 AAA domain AAA_33 PF13671.6 EFW98438.1 - 8.4e-09 35.7 0.9 0.008 16.3 0.0 3.5 3 1 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EFW98438.1 - 9.4e-09 35.4 0.2 0.0013 18.7 0.0 3.5 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFW98438.1 - 1.9e-07 31.2 0.0 0.02 14.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EFW98438.1 - 2.6e-07 30.9 0.0 0.0021 18.2 0.0 3.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EFW98438.1 - 1e-06 29.1 0.0 0.041 14.3 0.0 2.6 2 0 0 2 2 2 2 RNA helicase NB-ARC PF00931.22 EFW98438.1 - 1.2e-06 27.9 0.0 0.29 10.3 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain IstB_IS21 PF01695.17 EFW98438.1 - 1.5e-06 28.1 0.0 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.27 EFW98438.1 - 2.7e-06 27.9 0.4 0.016 15.7 0.1 3.3 3 1 0 3 3 2 2 ABC transporter Mg_chelatase PF01078.21 EFW98438.1 - 5.1e-06 26.0 0.0 0.064 12.6 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EFW98438.1 - 5.7e-06 25.8 0.1 0.1 11.8 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain Sigma54_activat PF00158.26 EFW98438.1 - 7e-06 25.8 0.0 0.035 13.8 0.0 2.8 3 0 0 3 3 2 2 Sigma-54 interaction domain Rad17 PF03215.15 EFW98438.1 - 7.4e-06 26.0 0.0 0.076 12.9 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_28 PF13521.6 EFW98438.1 - 1.6e-05 25.2 0.1 0.46 10.7 0.0 3.4 2 1 1 3 3 3 2 AAA domain DUF815 PF05673.13 EFW98438.1 - 1.8e-05 24.1 0.0 0.22 10.7 0.0 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF815) AAA_25 PF13481.6 EFW98438.1 - 2e-05 24.2 1.0 0.59 9.7 0.0 4.3 3 1 0 4 4 4 1 AAA domain AAA_18 PF13238.6 EFW98438.1 - 2.2e-05 25.0 0.0 0.16 12.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EFW98438.1 - 3.1e-05 23.6 0.1 0.12 11.8 0.0 3.1 3 0 0 3 3 3 2 P-loop containing dynein motor region ATPase PF06745.13 EFW98438.1 - 4.2e-05 23.0 0.0 0.025 13.9 0.0 2.6 2 0 0 2 2 2 1 KaiC AAA_24 PF13479.6 EFW98438.1 - 0.0001 22.1 0.1 0.28 10.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.6 EFW98438.1 - 0.00013 22.0 0.0 0.53 10.4 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.18 EFW98438.1 - 0.00025 21.0 0.0 0.14 12.0 0.1 3.1 2 1 0 2 2 2 1 Bacterial dnaA protein ATPase_2 PF01637.18 EFW98438.1 - 0.00025 21.0 0.0 0.34 10.8 0.0 2.9 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea TsaE PF02367.17 EFW98438.1 - 0.00038 20.4 0.0 0.75 9.8 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EFW98438.1 - 0.00061 19.1 0.0 0.53 9.5 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin ATP-synt_ab PF00006.25 EFW98438.1 - 0.00079 19.1 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain PhoH PF02562.16 EFW98438.1 - 0.00099 18.6 0.3 0.32 10.4 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein NACHT PF05729.12 EFW98438.1 - 0.0015 18.5 1.3 1.9 8.4 0.0 3.5 3 1 0 4 4 3 1 NACHT domain Vps4_C PF09336.10 EFW98438.1 - 0.0018 18.2 0.0 0.014 15.4 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Parvo_NS1 PF01057.17 EFW98438.1 - 0.0057 15.8 0.1 2.4 7.2 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 EFW98438.1 - 0.0076 16.6 0.0 4.2 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EFW98438.1 - 0.0084 15.9 0.1 3.5 7.3 0.1 2.7 2 0 0 2 2 2 1 Cytidylate kinase ResIII PF04851.15 EFW98438.1 - 0.0091 16.0 0.0 6.7 6.7 0.0 2.9 3 1 0 3 3 2 0 Type III restriction enzyme, res subunit SKI PF01202.22 EFW98438.1 - 0.013 15.6 0.1 3.5 7.7 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase AAA_3 PF07726.11 EFW98438.1 - 0.021 14.7 0.0 2.9 7.8 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EFW98438.1 - 0.023 14.5 2.9 1.5 8.5 0.0 3.4 3 1 0 3 3 3 0 AAA domain TniB PF05621.11 EFW98438.1 - 0.03 13.7 0.0 4.4 6.7 0.0 2.8 3 0 0 3 3 2 0 Bacterial TniB protein AAA_PrkA PF08298.11 EFW98438.1 - 0.042 12.8 0.0 0.12 11.3 0.0 1.6 2 0 0 2 2 2 0 PrkA AAA domain AAA_23 PF13476.6 EFW98438.1 - 0.052 14.1 0.1 0.49 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 EFW98438.1 - 0.059 12.8 0.0 6.1 6.2 0.0 2.9 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFW98438.1 - 0.068 13.1 0.1 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 EFW98438.1 - 0.071 12.9 0.0 3.8 7.2 0.0 3.1 2 2 1 3 3 3 0 DEAD/DEAH box helicase AAA_17 PF13207.6 EFW98438.1 - 0.079 13.4 6.1 1.6 9.1 0.0 3.2 4 0 0 4 4 2 0 AAA domain DTHCT PF08070.11 EFW98438.1 - 0.082 13.7 4.2 0.21 12.4 4.2 1.6 1 0 0 1 1 1 0 DTHCT (NUC029) region DUF2075 PF09848.9 EFW98438.1 - 0.09 12.0 0.0 9.6 5.3 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IPT PF01745.16 EFW98438.1 - 0.15 11.4 0.2 17 4.7 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase PduV-EutP PF10662.9 EFW98438.1 - 0.15 11.8 0.0 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Methyltransf_11 PF08241.12 EFW98439.1 - 3.1e-11 43.8 0.0 5.3e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW98439.1 - 3.9e-10 40.3 0.0 8.3e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW98439.1 - 2.1e-06 27.7 0.0 3.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW98439.1 - 5.6e-06 27.0 0.0 1.1e-05 26.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW98439.1 - 0.016 15.0 0.0 0.049 13.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFW98439.1 - 0.016 14.5 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DREV PF05219.12 EFW98439.1 - 0.24 10.5 0.0 0.36 9.9 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Cyclin PF08613.11 EFW98440.1 - 3.2e-30 105.6 0.7 6.7e-30 104.6 0.0 1.9 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFW98440.1 - 2.1e-05 24.2 0.0 3.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ndc1_Nup PF09531.10 EFW98440.1 - 1.3 7.6 7.9 2.3 6.8 7.9 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PEPcase PF00311.17 EFW98441.1 - 0.018 13.1 0.1 0.03 12.4 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase HTH_Tnp_1 PF01527.20 EFW98441.1 - 0.087 13.1 1.7 0.64 10.4 0.0 2.8 2 0 0 2 2 2 0 Transposase DUF1771 PF08590.10 EFW98442.1 - 9.4e-24 83.6 7.9 9.4e-24 83.6 7.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EFW98442.1 - 1.8e-11 44.2 0.5 1.8e-11 44.2 0.5 1.9 2 0 0 2 2 2 1 Smr domain NifU PF01106.17 EFW98443.1 - 2e-27 95.1 0.1 3.7e-27 94.3 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 EFW98443.1 - 3.6e-26 91.0 0.0 9.9e-26 89.6 0.0 1.7 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal YojJ PF10372.9 EFW98443.1 - 0.16 12.1 0.8 0.33 11.1 0.5 1.7 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Zn_clus PF00172.18 EFW98445.1 - 1.1e-09 38.3 9.0 1.1e-09 38.3 9.0 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EFW98446.1 - 0.011 15.7 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 0 F-box-like VEFS-Box PF09733.9 EFW98447.1 - 1.8e-10 40.8 0.3 4.3e-10 39.5 0.3 1.5 1 0 0 1 1 1 1 VEFS-Box of polycomb protein ATP-synt_C PF00137.21 EFW98448.1 - 7.7e-28 96.6 35.2 1e-16 61.0 11.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Zn_clus PF00172.18 EFW98449.1 - 2.8e-05 24.2 8.0 4.7e-05 23.4 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1961 PF09224.11 EFW98450.1 - 2.3e-101 337.6 0.0 2.6e-101 337.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) SKG6 PF08693.10 EFW98451.1 - 8.5e-11 41.1 3.4 2.9e-10 39.4 3.4 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 EFW98451.1 - 0.00012 21.9 0.2 0.00012 21.9 0.2 4.8 1 1 1 2 2 2 1 TMEM154 protein family Rax2 PF12768.7 EFW98451.1 - 0.0036 16.8 0.1 0.0072 15.8 0.1 1.4 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF4448 PF14610.6 EFW98451.1 - 0.0048 16.7 0.3 0.008 16.0 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) CD34_antigen PF06365.12 EFW98451.1 - 0.076 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family CcmD PF04995.14 EFW98451.1 - 0.091 12.9 3.2 0.17 12.0 3.2 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF4380 PF14315.6 EFW98452.1 - 0.12 11.2 0.1 0.16 10.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4380) BTB PF00651.31 EFW98453.1 - 0.00053 20.2 0.0 0.00092 19.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DJ-1_PfpI PF01965.24 EFW98454.1 - 1.9e-08 34.3 0.0 3.4e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EFW98454.1 - 0.052 13.2 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like CENP-H PF05837.12 EFW98455.1 - 1.9e-32 112.0 6.7 3.4e-32 111.2 4.1 2.0 2 0 0 2 2 2 1 Centromere protein H (CENP-H) HIP1_clath_bdg PF16515.5 EFW98455.1 - 0.0072 16.9 2.6 0.017 15.7 2.6 1.5 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Cwf_Cwc_15 PF04889.12 EFW98455.1 - 0.046 13.5 9.3 0.59 9.8 1.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein VCPO_N PF17897.1 EFW98455.1 - 0.078 12.8 0.2 0.12 12.1 0.2 1.2 1 0 0 1 1 1 0 Vanadium chloroperoxidase N-terminal domain DUF2721 PF11026.8 EFW98455.1 - 1 9.3 3.1 19 5.1 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) TPR_12 PF13424.6 EFW98456.1 - 3.1e-07 30.6 5.1 1.8e-05 24.9 2.8 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFW98456.1 - 4e-07 29.7 9.6 0.0048 16.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFW98456.1 - 5.8e-05 22.7 5.4 0.059 13.2 1.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFW98456.1 - 0.0076 15.9 3.1 0.54 10.0 0.3 2.9 3 0 0 3 3 3 2 TPR repeat TPR_14 PF13428.6 EFW98456.1 - 0.18 12.7 2.4 58 4.9 1.6 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFW98456.1 - 0.3 11.8 1.9 39 5.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFW98456.1 - 0.32 11.1 1.4 3.2 8.0 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat FMO-like PF00743.19 EFW98457.1 - 2.3e-10 39.5 0.1 1.4e-09 37.0 0.0 2.0 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFW98457.1 - 3.5e-08 33.6 0.0 1.1e-07 32.0 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW98457.1 - 2.4e-07 30.3 0.0 0.0065 15.7 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFW98457.1 - 4.7e-06 26.0 0.1 0.044 12.9 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFW98457.1 - 8.2e-06 25.9 1.4 0.0012 18.8 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFW98457.1 - 7.5e-05 22.1 0.0 0.0015 17.9 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFW98457.1 - 0.00015 21.5 1.7 0.03 13.9 0.3 3.3 2 1 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFW98457.1 - 0.0012 18.1 0.1 0.032 13.5 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EFW98457.1 - 0.0027 18.2 0.4 14 6.3 0.0 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.12 EFW98457.1 - 0.01 15.4 0.6 0.61 9.6 0.0 2.4 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain HI0933_like PF03486.14 EFW98457.1 - 0.24 10.0 0.4 0.96 8.1 0.2 2.0 2 0 0 2 2 2 0 HI0933-like protein Glyco_hydro_3 PF00933.21 EFW98458.1 - 2.6e-44 151.9 0.0 4.2e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFW98458.1 - 5.9e-11 42.7 0.1 8.5e-08 32.4 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain ADH_zinc_N_2 PF13602.6 EFW98458.1 - 1.1e-08 36.2 0.0 3.9e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFW98458.1 - 3.2e-07 30.4 0.0 7.3e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Cofilin_ADF PF00241.20 EFW98459.1 - 2.4e-39 133.9 0.1 2.8e-39 133.7 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PP2C PF00481.21 EFW98460.1 - 3.2e-41 141.7 0.0 5.7e-41 140.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Glyco_hydro_63 PF03200.16 EFW98460.1 - 2.8e-08 33.0 1.9 2.2e-05 23.5 0.1 3.2 2 1 0 2 2 2 2 Glycosyl hydrolase family 63 C-terminal domain PP2C_2 PF13672.6 EFW98460.1 - 0.022 14.4 1.4 0.044 13.4 0.3 1.9 2 0 0 2 2 2 0 Protein phosphatase 2C SpoIIE PF07228.12 EFW98460.1 - 0.023 14.6 0.1 0.37 10.7 0.0 2.5 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) COesterase PF00135.28 EFW98461.1 - 1.3e-57 195.8 0.0 1.7e-57 195.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFW98461.1 - 2.1e-06 27.7 0.9 0.0023 17.8 0.0 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold KCNQ2_u3 PF16642.5 EFW98462.1 - 0.028 15.4 1.9 0.034 15.1 1.9 1.1 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Peptidase_C97 PF05903.14 EFW98463.1 - 6.3e-34 117.0 0.0 7.9e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EFW98463.1 - 0.0077 16.5 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Sds3 PF08598.11 EFW98464.1 - 2.4e-10 40.8 19.4 2.4e-10 40.8 19.4 2.6 2 2 0 2 2 2 1 Sds3-like TFIIA PF03153.13 EFW98464.1 - 0.0047 17.0 27.5 0.0047 17.0 27.5 3.2 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit tRNA-synt_1e PF01406.19 EFW98465.1 - 6.5e-116 386.9 0.0 9.8e-116 386.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFW98465.1 - 1.9e-06 26.9 0.3 0.023 13.4 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 EFW98465.1 - 0.0048 15.9 0.2 0.98 8.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (K) Flot PF15975.5 EFW98465.1 - 3.5 7.8 9.0 15 5.8 9.0 2.1 1 0 0 1 1 1 0 Flotillin Sds3 PF08598.11 EFW98467.1 - 5.1e-26 92.0 3.3 1.6e-25 90.4 3.3 1.8 1 1 0 1 1 1 1 Sds3-like Transcrip_reg PF01709.20 EFW98469.1 - 3.1e-65 219.9 0.0 3.7e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator NAD_binding_8 PF13450.6 EFW98470.1 - 1.7e-08 34.6 0.1 3.5e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EFW98470.1 - 9.2e-08 31.8 0.0 1.8e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EFW98470.1 - 0.00053 19.3 0.2 0.018 14.3 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFW98470.1 - 0.0081 15.4 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EFW98470.1 - 0.0083 15.4 0.2 0.013 14.8 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFW98470.1 - 0.017 14.5 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DAO PF01266.24 EFW98470.1 - 0.02 14.5 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 EFW98470.1 - 0.036 13.3 0.1 0.068 12.4 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EFW98470.1 - 0.041 12.9 0.2 0.073 12.1 0.2 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 EFW98470.1 - 0.044 12.5 0.1 0.066 11.9 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 EFW98470.1 - 0.045 14.0 0.0 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 EFW98470.1 - 0.086 12.8 0.2 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EFW98470.1 - 0.087 11.9 0.2 0.13 11.3 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Fungal_trans PF04082.18 EFW98471.1 - 3.3e-12 46.0 0.0 7.2e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFW98471.1 - 0.00057 20.0 5.5 0.0013 18.8 5.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP_bind_3 PF01171.20 EFW98472.1 - 2.7e-36 125.0 0.0 2.7e-25 89.2 0.0 2.2 2 0 0 2 2 2 2 PP-loop family DUF5315 PF17242.2 EFW98473.1 - 1.7e-27 95.0 0.7 1.7e-27 95.0 0.7 2.1 2 0 0 2 2 2 1 Disordered region of unknown function (DUF5315) Arf PF00025.21 EFW98474.1 - 4.4e-74 247.7 0.0 5.3e-74 247.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFW98474.1 - 6e-15 55.5 0.0 8e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFW98474.1 - 2.6e-14 53.1 0.0 3.1e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFW98474.1 - 5.4e-12 45.5 0.3 6.4e-08 32.1 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFW98474.1 - 2.1e-11 43.7 0.0 2.4e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFW98474.1 - 5e-09 35.9 0.0 6.3e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFW98474.1 - 2.7e-07 30.7 0.0 4.6e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFW98474.1 - 3.7e-05 23.3 0.0 0.0029 17.2 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFW98474.1 - 0.0054 16.3 0.9 0.023 14.2 0.9 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EFW98474.1 - 0.1 13.1 0.1 0.24 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 EFW98475.1 - 7e-10 39.4 4.2 0.01 16.6 0.1 8.0 9 0 0 9 9 9 2 WD domain, G-beta repeat TFIIA PF03153.13 EFW98475.1 - 1.4 8.8 20.6 8.7 6.2 16.9 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ALMT PF11744.8 EFW98475.1 - 1.5 7.6 5.5 2.6 6.8 5.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 EFW98475.1 - 2 8.2 13.5 5.2 6.8 13.5 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_C14 PF00656.22 EFW98477.1 - 4.1e-61 207.1 0.0 5.2e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Mito_carr PF00153.27 EFW98478.1 - 6.3e-55 183.1 0.7 6.7e-19 67.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein MotA_ExbB PF01618.16 EFW98478.1 - 0.13 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family DUF3764 PF12594.8 EFW98478.1 - 0.15 12.2 0.0 9.9 6.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3764) NUDIX PF00293.28 EFW98479.1 - 2.2e-27 95.7 0.0 3.2e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain cobW PF02492.19 EFW98480.1 - 1e-47 162.0 0.1 1.4e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFW98480.1 - 8.1e-06 25.7 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EFW98480.1 - 0.00032 20.6 0.0 0.29 11.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 EFW98480.1 - 0.0061 16.3 0.3 0.31 10.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EFW98480.1 - 0.0099 14.9 1.0 2.3 7.1 0.0 2.8 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EFW98480.1 - 0.013 15.9 0.1 0.037 14.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 EFW98480.1 - 0.013 15.0 0.1 5.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 EFW98480.1 - 0.018 15.6 0.1 0.031 14.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFW98480.1 - 0.023 14.5 0.1 0.85 9.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 EFW98480.1 - 0.025 14.3 0.1 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFW98480.1 - 0.044 13.9 0.0 0.1 12.7 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EFW98480.1 - 0.071 13.4 0.3 0.38 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFW98480.1 - 0.092 12.0 0.0 0.42 9.9 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 EFW98480.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFW98480.1 - 0.11 13.0 0.0 0.4 11.2 0.1 1.9 2 0 0 2 2 1 0 AAA domain T2SSE PF00437.20 EFW98480.1 - 0.13 11.3 1.0 0.18 10.8 0.2 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Zn_clus PF00172.18 EFW98481.1 - 2.6e-06 27.4 12.2 4.1e-06 26.8 12.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RibD_C PF01872.17 EFW98482.1 - 5.4e-33 114.5 0.0 6.4e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain PTCB-BRCT PF12738.7 EFW98482.1 - 0.16 11.9 0.1 1.6 8.7 0.0 2.1 2 0 0 2 2 2 0 twin BRCT domain DUF382 PF04037.13 EFW98483.1 - 3.1e-59 198.7 0.3 3.1e-59 198.7 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EFW98483.1 - 2.9e-19 68.7 6.5 5.8e-19 67.7 6.5 1.6 1 0 0 1 1 1 1 PSP tRNA-synt_1 PF00133.22 EFW98484.1 - 3.1e-147 491.4 0.0 4e-147 491.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFW98484.1 - 3.4e-21 75.4 0.0 5.8e-13 48.4 0.0 3.6 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFW98484.1 - 4.8e-15 55.8 0.0 7.9e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.14 EFW98484.1 - 0.00045 20.0 3.2 0.00094 19.0 3.2 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS DUF35_N PF12172.8 EFW98484.1 - 0.011 15.7 2.8 0.011 15.7 2.8 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) tRNA-synt_1e PF01406.19 EFW98484.1 - 0.063 12.6 0.0 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DUF945 PF06097.11 EFW98484.1 - 0.088 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) tRNA-synt_1_2 PF13603.6 EFW98484.1 - 0.19 11.2 0.0 0.76 9.3 0.0 1.8 2 0 0 2 2 2 0 Leucyl-tRNA synthetase, Domain 2 TIG PF01833.24 EFW98486.1 - 2.9e-11 43.3 1.1 8e-11 41.9 0.4 2.1 2 0 0 2 2 2 1 IPT/TIG domain Ank_5 PF13857.6 EFW98486.1 - 3.6e-11 43.1 0.3 1.1e-10 41.5 0.3 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFW98486.1 - 1.1e-09 38.2 3.2 6.1e-06 26.4 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EFW98486.1 - 5.7e-08 33.3 0.0 1.5e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFW98486.1 - 7e-06 26.0 0.5 0.0092 16.4 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFW98486.1 - 4.5e-05 23.9 0.2 0.00092 19.7 0.2 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) DUF1980 PF09323.10 EFW98486.1 - 0.044 13.7 0.1 0.17 11.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SUIM_assoc PF16619.5 EFW98486.1 - 7.8 6.7 9.5 0.83 9.8 2.1 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Cytochrom_C PF00034.21 EFW98487.1 - 5.6e-11 43.4 0.0 7.4e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EFW98487.1 - 6.5e-09 36.0 1.5 2.8e-08 33.9 1.5 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EFW98487.1 - 0.026 14.3 1.8 0.087 12.5 1.8 2.0 1 1 0 1 1 1 0 Cytochrome c-550 domain AAA PF00004.29 EFW98488.1 - 1.1e-35 123.0 0.1 1.7e-33 115.8 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) BSD PF03909.17 EFW98488.1 - 9.9e-30 102.3 2.6 7.8e-14 51.4 0.3 2.7 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 EFW98488.1 - 5.9e-25 87.4 0.0 2.2e-24 85.6 0.0 2.0 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain AAA_lid_3 PF17862.1 EFW98488.1 - 1.5e-10 40.7 0.3 4.5e-10 39.2 0.3 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EFW98488.1 - 5e-06 26.8 0.8 0.073 13.3 0.1 4.2 3 1 0 4 4 4 1 AAA domain AAA_14 PF13173.6 EFW98488.1 - 0.00024 21.2 0.0 0.035 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFW98488.1 - 0.00052 19.8 0.0 0.0017 18.1 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EFW98488.1 - 0.001 19.5 7.6 0.0054 17.1 0.1 4.5 3 1 0 4 4 3 1 AAA ATPase domain RuvB_N PF05496.12 EFW98488.1 - 0.0022 17.8 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EFW98488.1 - 0.0048 17.2 0.1 0.14 12.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFW98488.1 - 0.006 16.7 0.0 0.066 13.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFW98488.1 - 0.024 14.0 0.2 0.21 10.9 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFW98488.1 - 0.044 14.3 0.0 0.15 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain DHC_N1 PF08385.12 EFW98488.1 - 0.051 12.2 0.1 1.8 7.1 0.0 2.2 2 0 0 2 2 2 0 Dynein heavy chain, N-terminal region 1 AAA_5 PF07728.14 EFW98488.1 - 0.06 13.3 0.1 0.19 11.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFW98488.1 - 0.12 12.0 0.1 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 EFW98488.1 - 0.14 11.9 0.2 0.54 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF4214 PF13946.6 EFW98488.1 - 0.15 12.1 0.1 18 5.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4214) ATPase_2 PF01637.18 EFW98488.1 - 0.15 12.0 0.1 25 4.7 0.0 3.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EFW98488.1 - 0.17 12.3 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 EFW98488.1 - 0.45 9.7 1.1 0.7 9.0 0.0 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain Spt5_N PF11942.8 EFW98488.1 - 7.6 7.6 13.7 5.5 8.0 0.6 4.0 4 0 0 4 4 3 0 Spt5 transcription elongation factor, acidic N-terminal Peripla_BP_3 PF13377.6 EFW98488.1 - 7.8 6.8 7.3 1.5 9.1 0.1 3.1 3 0 0 3 3 3 0 Periplasmic binding protein-like domain Ras PF00071.22 EFW98489.1 - 2.9e-56 189.6 0.0 3.3e-56 189.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFW98489.1 - 7.7e-22 77.8 0.0 1.1e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFW98489.1 - 1.5e-07 31.0 0.0 2.4e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFW98489.1 - 0.00048 19.6 0.0 0.00068 19.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 EFW98489.1 - 0.023 13.9 0.1 0.21 10.7 0.0 2.0 1 1 1 2 2 2 0 NB-ARC domain Gtr1_RagA PF04670.12 EFW98489.1 - 0.17 11.2 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Skp1 PF01466.19 EFW98489.1 - 0.28 11.3 1.4 1.1 9.5 0.3 2.4 3 0 0 3 3 3 0 Skp1 family, dimerisation domain IBR PF01485.21 EFW98492.1 - 1.9e-14 53.6 23.2 2.4e-12 46.9 7.2 3.6 3 1 0 3 3 3 3 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFW98492.1 - 0.0073 16.6 4.9 0.0073 16.6 4.9 3.6 3 0 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 EFW98492.1 - 0.039 13.8 1.9 0.039 13.8 1.9 3.7 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFW98492.1 - 0.062 13.2 1.2 0.062 13.2 1.2 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EFW98492.1 - 0.12 12.2 17.4 0.22 11.3 4.6 3.4 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain adh_short PF00106.25 EFW98493.1 - 8.7e-39 133.0 0.1 1.2e-38 132.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW98493.1 - 5.5e-34 117.7 0.8 2.8e-32 112.1 0.8 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFW98493.1 - 0.0018 17.8 0.1 0.0058 16.1 0.0 1.9 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFW98493.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase GFA PF04828.14 EFW98494.1 - 1.6e-11 44.4 1.8 2.7e-05 24.4 3.5 2.9 2 1 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme zf-dskA_traR PF01258.17 EFW98494.1 - 0.036 14.0 3.6 1 9.4 0.1 2.9 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger RPE65 PF03055.15 EFW98495.1 - 2.9e-103 346.6 0.0 3.3e-103 346.4 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein HSP70 PF00012.20 EFW98496.1 - 1.1e-08 33.8 0.1 4.2e-07 28.6 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein FtsA PF14450.6 EFW98496.1 - 0.0053 17.2 0.1 0.026 15.0 0.0 2.2 2 0 0 2 2 2 1 Cell division protein FtsA Kinesin PF00225.23 EFW98497.1 - 4.6e-97 324.9 1.0 8.5e-97 324.0 1.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFW98497.1 - 4e-15 56.1 0.3 2.4e-14 53.5 0.1 2.4 2 1 0 2 2 2 1 Microtubule binding Microtub_bind PF13931.6 EFW98497.1 - 0.0018 18.6 0.1 0.0018 18.6 0.1 4.4 4 1 1 5 5 5 1 Kinesin-associated microtubule-binding Apolipoprotein PF01442.18 EFW98497.1 - 0.0032 17.4 68.7 0.014 15.3 21.7 5.6 2 1 2 4 4 4 2 Apolipoprotein A1/A4/E domain PhaC_N PF07167.13 EFW98497.1 - 0.066 12.9 0.6 0.3 10.7 0.1 2.4 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus COMP PF11598.8 EFW98497.1 - 0.57 10.7 2.1 1.6 9.2 0.1 2.9 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Rer1 PF03248.13 EFW98499.1 - 3.5e-80 267.7 4.7 4e-80 267.5 4.7 1.0 1 0 0 1 1 1 1 Rer1 family eIF-3_zeta PF05091.12 EFW98500.1 - 0.67 8.9 5.7 1.1 8.2 5.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hydin_ADK PF17213.3 EFW98500.1 - 2.7 8.2 5.2 1.3 9.3 0.7 2.5 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Het-C PF07217.11 EFW98501.1 - 8.1e-238 790.5 0.0 1e-237 790.2 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C AATase PF07247.12 EFW98502.1 - 1.2e-08 34.0 0.0 2.5e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EFW98502.1 - 7.7e-05 21.5 0.0 0.00044 19.1 0.0 1.8 2 0 0 2 2 2 1 Condensation domain SPRY PF00622.28 EFW98503.1 - 0.0035 17.5 0.0 0.0079 16.3 0.0 1.6 1 1 0 1 1 1 1 SPRY domain MARVEL PF01284.23 EFW98504.1 - 5.6e-21 75.1 21.2 6.7e-21 74.8 21.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain cwf21 PF08312.12 EFW98505.1 - 9.7e-15 54.5 5.9 9.7e-15 54.5 5.9 2.1 2 0 0 2 2 2 1 cwf21 domain GvpG PF05120.12 EFW98505.1 - 0.095 12.7 5.5 0.26 11.3 0.1 2.6 2 1 0 2 2 2 0 Gas vesicle protein G DUF4210 PF13915.6 EFW98506.1 - 2.4e-31 108.1 0.1 6.8e-31 106.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 EFW98506.1 - 3.3e-23 81.6 1.3 7.3e-23 80.5 1.3 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis p450 PF00067.22 EFW98507.1 - 5.7e-45 153.9 0.0 6.9e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GWT1 PF06423.12 EFW98508.1 - 1.1e-37 129.5 0.0 3.9e-37 127.6 0.0 2.0 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 EFW98508.1 - 0.0027 18.1 0.1 0.0091 16.5 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4818) AMP-binding PF00501.28 EFW98509.1 - 7.8e-83 278.4 0.0 1.1e-82 278.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FSH1 PF03959.13 EFW98510.1 - 1.5e-28 99.9 0.0 5.9e-28 98.0 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EFW98510.1 - 1.2e-05 26.0 1.5 1.7e-05 25.5 1.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFW98510.1 - 0.0012 18.5 0.0 0.063 12.9 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EFW98510.1 - 0.003 17.4 0.6 0.14 12.0 0.6 2.9 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase PE-PPE PF08237.11 EFW98510.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.3 1 1 0 1 1 1 0 PE-PPE domain DUF5493 PF17597.2 EFW98511.1 - 0.057 13.7 4.3 0.15 12.4 2.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5493) DUF1270 PF06900.11 EFW98511.1 - 0.16 12.4 6.7 0.51 10.8 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1270) Membr_traf_MHD PF10540.9 EFW98511.1 - 0.2 11.8 0.0 0.3 11.3 0.0 1.2 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain Sec1 PF00995.23 EFW98512.1 - 1.6e-117 394.2 0.0 1.9e-117 393.9 0.0 1.1 1 0 0 1 1 1 1 Sec1 family MatE PF01554.18 EFW98512.1 - 6.2e-54 182.0 27.7 9.2e-29 100.2 10.0 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EFW98512.1 - 0.00014 21.9 8.2 0.00014 21.9 8.2 3.1 4 0 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain CobA_CobO_BtuR PF02572.15 EFW98512.1 - 0.23 11.7 0.4 0.56 10.5 0.4 1.6 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Cu_bind_like PF02298.17 EFW98513.1 - 0.011 15.7 0.2 0.064 13.3 0.2 2.1 1 1 0 1 1 1 0 Plastocyanin-like domain DAO PF01266.24 EFW98514.1 - 2.9e-41 142.2 5.6 3.4e-41 142.0 5.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFW98514.1 - 0.00083 18.7 1.1 0.0024 17.2 1.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFW98514.1 - 0.005 17.1 0.4 0.011 15.9 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFW98514.1 - 0.0051 16.1 0.1 0.0094 15.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EFW98514.1 - 0.048 12.7 5.9 0.11 11.5 3.5 2.1 2 0 0 2 2 2 0 FAD binding domain MCRA PF06100.11 EFW98514.1 - 0.28 9.9 0.4 0.42 9.4 0.4 1.1 1 0 0 1 1 1 0 MCRA family GIDA PF01134.22 EFW98514.1 - 0.84 8.6 3.0 1.2 8.1 3.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A PH PF00169.29 EFW98515.1 - 0.2 12.2 0.0 0.9 10.1 0.0 2.1 2 0 0 2 2 2 0 PH domain Glyco_transf_90 PF05686.12 EFW98516.1 - 1.9e-14 53.4 8.6 1.8e-10 40.3 8.1 3.0 2 1 0 2 2 2 2 Glycosyl transferase family 90 DUF932 PF06067.11 EFW98516.1 - 0.049 13.4 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF932) Kelch_4 PF13418.6 EFW98517.1 - 3.4e-28 97.4 8.8 6.1e-09 35.7 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFW98517.1 - 6.7e-25 86.5 4.7 3.6e-05 23.9 0.0 5.3 3 1 2 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EFW98517.1 - 2.2e-22 78.6 4.0 3.3e-05 23.8 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFW98517.1 - 3.8e-21 74.4 0.4 5.7e-05 22.6 0.0 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFW98517.1 - 2.1e-19 69.3 7.6 1.1e-06 28.7 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFW98517.1 - 1.1e-17 63.3 5.2 0.00012 21.9 0.0 5.3 5 0 0 5 5 5 4 Kelch motif BTB PF00651.31 EFW98517.1 - 3.4e-07 30.5 0.0 2e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EFW98517.1 - 0.09 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch zf-RING_6 PF14835.6 EFW98518.1 - 0.2 11.5 4.0 0.33 10.9 4.0 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 EFW98518.1 - 0.55 10.1 8.6 0.88 9.5 8.6 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3984 PF13136.6 EFW98519.1 - 1.6e-45 156.0 29.7 1.6e-45 156.0 29.7 3.7 2 1 0 2 2 2 1 Protein of unknown function (DUF3984) PPP4R2 PF09184.11 EFW98519.1 - 0.095 12.3 4.4 0.1 12.2 3.7 1.3 1 1 0 1 1 1 0 PPP4R2 RXT2_N PF08595.11 EFW98519.1 - 1 9.4 4.7 1.8 8.6 4.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal SDA1 PF05285.12 EFW98519.1 - 1.4 8.3 8.6 2.1 7.7 8.6 1.3 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 EFW98519.1 - 1.4 8.8 5.5 2 8.2 5.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.12 EFW98519.1 - 4.7 6.4 16.4 8.6 5.6 16.4 1.3 1 0 0 1 1 1 0 NOA36 protein RRN3 PF05327.11 EFW98519.1 - 5.2 5.5 10.0 6.7 5.1 10.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 EFW98519.1 - 5.5 5.1 10.5 9 4.4 10.5 1.2 1 0 0 1 1 1 0 Nop14-like family TPT PF03151.16 EFW98520.1 - 4.2e-25 88.7 25.7 5.4e-25 88.3 25.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFW98520.1 - 0.05 13.8 43.8 0.066 13.4 12.4 2.7 3 0 0 3 3 3 0 EamA-like transporter family DUF4452 PF14618.6 EFW98521.1 - 2.3e-48 164.3 9.9 2.6e-48 164.1 9.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) MFS_1 PF07690.16 EFW98522.1 - 1e-34 120.0 39.9 1e-34 120.0 39.9 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily HCV_NS5a_C PF12941.7 EFW98522.1 - 0.071 13.0 0.5 0.14 12.0 0.5 1.4 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region adh_short PF00106.25 EFW98523.1 - 4.9e-32 111.0 2.0 1.5e-30 106.2 2.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW98523.1 - 1.3e-25 90.4 0.0 1.8e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW98523.1 - 1.4e-07 31.6 2.9 3.9e-06 26.9 0.0 2.3 1 1 1 2 2 2 2 KR domain DUF1776 PF08643.10 EFW98523.1 - 0.08 12.3 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Amidohydro_1 PF01979.20 EFW98524.1 - 3.8e-72 243.5 0.5 7.9e-72 242.4 0.5 1.5 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 EFW98524.1 - 2e-49 166.9 0.3 4.8e-49 165.7 0.3 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 EFW98524.1 - 3.3e-40 136.4 0.0 7.8e-40 135.2 0.0 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 EFW98524.1 - 6.1e-40 135.2 0.1 1.9e-39 133.6 0.0 1.9 2 0 0 2 2 2 1 Urease beta subunit Amidohydro_3 PF07969.11 EFW98524.1 - 3.9e-08 33.2 10.2 4.5e-05 23.1 0.6 3.4 4 1 0 4 4 4 2 Amidohydrolase family Amidohydro_2 PF04909.14 EFW98524.1 - 0.0075 16.1 0.1 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase RINGv PF12906.7 EFW98525.1 - 7.1e-07 29.3 5.3 7.1e-07 29.3 5.3 2.2 2 0 0 2 2 2 1 RING-variant domain Ribosomal_L27e PF01777.18 EFW98526.1 - 1.8e-37 127.5 5.1 2.4e-37 127.2 5.1 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EFW98526.1 - 0.013 15.4 0.7 0.013 15.4 0.7 2.3 3 0 0 3 3 3 0 KOW motif Tubulin PF00091.25 EFW98527.1 - 1.3e-61 208.3 0.0 1.7e-61 207.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFW98527.1 - 2.6e-44 150.4 0.0 3.9e-44 149.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFW98527.1 - 5.7e-05 22.9 0.0 0.0001 22.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain MFS_1 PF07690.16 EFW98529.1 - 7.1e-18 64.7 39.5 1e-13 51.0 16.9 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF4617 PF15395.6 EFW98530.1 - 0.094 11.0 2.1 0.12 10.6 2.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4617) Urb2 PF10441.9 EFW98531.1 - 1.7e-52 178.4 0.0 4.3e-52 177.0 0.0 1.7 1 0 0 1 1 1 1 Urb2/Npa2 family Cyclin_N PF00134.23 EFW98532.1 - 2.2e-12 46.8 0.1 8.3e-12 45.0 0.2 1.9 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EFW98532.1 - 0.017 15.5 0.2 0.072 13.5 0.0 2.0 2 0 0 2 2 2 0 Cyclin C-terminal domain TFIIB PF00382.19 EFW98532.1 - 0.069 13.2 0.1 0.25 11.4 0.1 2.0 1 0 0 1 1 1 0 Transcription factor TFIIB repeat MOSC_N PF03476.16 EFW98534.1 - 4.5e-08 33.0 0.0 1.6e-07 31.2 0.0 1.7 1 1 1 2 2 2 1 MOSC N-terminal beta barrel domain RasGEF PF00617.19 EFW98535.1 - 4.1e-60 203.0 0.0 8.9e-60 201.9 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFW98535.1 - 2.7e-28 98.3 0.4 6.8e-28 97.0 0.4 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EFW98535.1 - 1.8e-15 56.3 0.1 3.6e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFW98535.1 - 4.1e-14 52.2 0.2 8.3e-14 51.2 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFW98535.1 - 4.4e-13 48.7 0.1 1e-12 47.5 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EFW98535.1 - 0.0039 17.2 0.0 0.0081 16.2 0.0 1.5 1 0 0 1 1 1 1 WW domain UDPGT PF00201.18 EFW98536.1 - 8.1e-14 51.3 0.0 1.5e-13 50.4 0.0 1.3 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.6 EFW98536.1 - 0.047 12.9 0.1 0.74 9.0 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.16 EFW98536.1 - 0.067 13.2 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain MFS_1 PF07690.16 EFW98538.1 - 3.6e-34 118.3 88.9 3.7e-25 88.6 49.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S15 PF02129.18 EFW98538.1 - 0.089 12.4 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1129 PF06570.11 EFW98538.1 - 1.2 8.6 3.2 0.61 9.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) FIST PF08495.10 EFW98538.1 - 2.1 8.3 6.9 0.24 11.4 0.6 2.2 2 1 0 2 2 2 0 FIST N domain CHD5 PF04420.14 EFW98539.1 - 2.1e-58 196.7 0.1 2.6e-58 196.4 0.1 1.1 1 0 0 1 1 1 1 CHD5-like protein PcfJ PF14284.6 EFW98539.1 - 0.047 13.6 0.1 0.064 13.1 0.1 1.2 1 0 0 1 1 1 0 PcfJ-like protein DUF469 PF04320.14 EFW98539.1 - 0.1 13.4 0.0 0.51 11.2 0.0 1.9 1 1 1 2 2 2 0 Protein with unknown function (DUF469) DUF1515 PF07439.11 EFW98539.1 - 0.21 11.6 1.9 0.26 11.3 0.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) PS-DH PF14765.6 EFW98540.1 - 1.9e-57 194.8 0.3 1.9e-57 194.8 0.3 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFW98540.1 - 1.1e-36 127.0 2.1 4.6e-36 124.9 2.1 2.0 1 1 0 1 1 1 1 Acyl transferase domain Methyltransf_12 PF08242.12 EFW98540.1 - 1.9e-19 70.2 0.0 5.6e-19 68.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW98540.1 - 1.5e-12 48.1 0.1 1.5e-11 44.9 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW98540.1 - 1.9e-11 44.0 0.0 4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW98540.1 - 6.5e-10 39.5 0.1 7e-09 36.2 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain FAD_binding_4 PF01565.23 EFW98540.1 - 7.3e-09 35.5 0.1 6.3e-06 26.0 0.0 2.8 2 0 0 2 2 2 2 FAD binding domain Methyltransf_31 PF13847.6 EFW98540.1 - 1.1e-07 31.7 0.0 2.8e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFW98540.1 - 1.7e-05 24.3 0.0 3.3e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family SAT PF16073.5 EFW98540.1 - 0.00042 20.1 3.7 0.00085 19.1 3.7 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_16 PF10294.9 EFW98540.1 - 0.0039 17.0 0.0 0.012 15.3 0.0 1.7 1 1 0 1 1 1 1 Lysine methyltransferase NodS PF05401.11 EFW98540.1 - 0.064 12.9 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ribosomal_L23 PF00276.20 EFW98541.1 - 1e-08 35.4 0.0 4.1e-08 33.5 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein L23 ATP_sub_h PF10775.9 EFW98541.1 - 0.1 12.6 0.1 0.93 9.5 0.1 2.2 2 0 0 2 2 2 0 ATP synthase complex subunit h Zn_clus PF00172.18 EFW98542.1 - 9.4e-07 28.9 12.7 1.8e-06 28.0 12.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFW98542.1 - 1.1e-05 24.7 1.1 1.7e-05 24.0 1.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TPP_enzyme_M PF00205.22 EFW98542.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DUF3245 PF11595.8 EFW98543.1 - 0.018 15.5 3.7 0.018 15.5 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) SRP-alpha_N PF04086.13 EFW98543.1 - 5.1 6.9 14.0 6.6 6.6 14.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ras PF00071.22 EFW98544.1 - 1e-53 181.3 0.0 1.1e-53 181.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFW98544.1 - 5.2e-21 75.1 0.0 7.5e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFW98544.1 - 9.4e-07 28.4 0.0 1.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PH PF00169.29 EFW98545.1 - 6.3e-24 84.5 1.4 2.9e-13 50.3 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EFW98545.1 - 1.2e-09 38.6 1.0 4.8e-05 23.7 0.2 3.6 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EFW98545.1 - 8.2e-08 32.6 5.3 0.0058 17.0 0.7 3.2 2 2 0 2 2 2 2 Pleckstrin homology domain Phage_GPD PF05954.11 EFW98545.1 - 0.03 13.6 0.1 0.06 12.6 0.1 1.5 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) PH_13 PF16652.5 EFW98545.1 - 0.074 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Mito_carr PF00153.27 EFW98546.1 - 2.4e-61 203.6 5.1 7e-22 77.2 0.1 4.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFW98546.1 - 0.087 12.0 0.0 1.1 8.4 0.0 2.5 2 1 0 2 2 2 0 Gammaproteobacterial serine protease MFS_1 PF07690.16 EFW98547.1 - 6.4e-29 101.0 37.6 6.4e-29 101.0 37.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EFW98547.1 - 0.00063 18.3 4.0 0.00063 18.3 4.0 2.4 3 0 0 3 3 3 2 Fungal trichothecene efflux pump (TRI12) TMEM43 PF07787.12 EFW98547.1 - 0.12 11.8 2.0 0.26 10.7 2.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 43 zf-C2H2 PF00096.26 EFW98548.1 - 3.7e-09 36.6 12.8 0.02 15.3 1.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFW98548.1 - 0.0004 21.0 9.5 3.7 8.6 1.2 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger BRF1 PF07741.13 EFW98548.1 - 0.13 12.6 9.2 0.43 10.9 9.2 1.8 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Zip PF02535.22 EFW98548.1 - 1 8.5 2.7 1.6 7.9 2.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Tim54 PF11711.8 EFW98548.1 - 1.7 7.3 9.7 4 6.1 9.7 1.6 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RPA43_OB PF17875.1 EFW98548.1 - 5.3 7.7 9.5 32 5.2 8.6 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I ALMT PF11744.8 EFW98548.1 - 8.3 5.1 11.6 12 4.6 11.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Pyr_redox_2 PF07992.14 EFW98549.1 - 2.5e-16 59.8 0.0 5.3e-13 48.9 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFW98549.1 - 5.8e-16 58.6 0.0 4.9e-13 49.0 0.0 3.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFW98549.1 - 1.1e-10 40.6 0.1 8.7e-09 34.3 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EFW98549.1 - 2.3e-07 30.3 0.1 5.6e-06 25.7 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EFW98549.1 - 5.7e-06 26.8 0.1 0.15 12.6 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFW98549.1 - 5.4e-05 22.4 1.6 0.021 14.0 0.1 2.7 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.6 EFW98549.1 - 6.7e-05 23.0 0.0 0.0028 17.9 0.0 3.3 4 0 0 4 4 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EFW98549.1 - 7.2e-05 22.2 0.4 0.045 13.0 0.1 2.6 3 0 0 3 3 3 2 FAD binding domain SnoaL_2 PF12680.7 EFW98549.1 - 0.00038 21.0 0.7 0.0032 18.1 0.0 2.7 2 1 0 2 2 2 1 SnoaL-like domain Shikimate_DH PF01488.20 EFW98549.1 - 0.0015 18.6 0.1 0.93 9.6 0.0 3.1 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EFW98549.1 - 0.034 14.0 0.1 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EFW98549.1 - 0.063 12.0 0.1 0.64 8.7 0.0 2.5 4 0 0 4 4 4 0 HI0933-like protein TrkA_N PF02254.18 EFW98549.1 - 0.079 13.2 0.0 13 6.1 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 EFW98549.1 - 0.11 11.9 0.0 3.4 7.0 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Aldose_epim PF01263.20 EFW98550.1 - 5e-44 150.8 0.0 7.1e-44 150.3 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase YABBY PF04690.13 EFW98551.1 - 0.094 13.3 0.9 0.13 12.8 0.9 1.2 1 0 0 1 1 1 0 YABBY protein Glyoxalase PF00903.25 EFW98552.1 - 1.3e-18 67.5 0.6 2.4e-15 56.8 0.0 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFW98552.1 - 3.6e-12 46.5 0.4 1.1e-05 25.7 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFW98552.1 - 6.4e-06 26.4 2.8 0.0021 18.2 0.1 3.3 2 2 0 2 2 2 2 Glyoxalase-like domain Cellulase PF00150.18 EFW98553.1 - 9.5e-10 38.4 0.0 0.00019 21.0 0.0 2.6 1 1 1 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Ecl1 PF12855.7 EFW98554.1 - 8.4e-13 49.8 33.8 1.5e-12 49.0 33.8 1.4 1 1 0 1 1 1 1 ECL1/2/3 zinc binding proteins GATA PF00320.27 EFW98555.1 - 6.1e-16 57.7 6.6 6.1e-16 57.7 6.6 1.9 2 0 0 2 2 2 1 GATA zinc finger PAS_3 PF08447.12 EFW98555.1 - 1.3e-09 38.2 0.0 2.6e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EFW98555.1 - 8.5e-09 35.4 0.0 1.8e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFW98555.1 - 0.00075 19.7 0.0 0.0015 18.8 0.0 1.5 1 0 0 1 1 1 1 PAS fold Zn-ribbon_8 PF09723.10 EFW98555.1 - 0.0035 17.4 0.2 0.0075 16.4 0.2 1.5 1 0 0 1 1 1 1 Zinc ribbon domain PAS_9 PF13426.7 EFW98555.1 - 0.006 16.8 0.0 0.016 15.5 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_11 PF14598.6 EFW98555.1 - 0.0077 16.3 0.0 0.019 15.1 0.0 1.6 2 0 0 2 2 2 1 PAS domain TF_Zn_Ribbon PF08271.12 EFW98555.1 - 0.14 11.7 0.5 0.93 9.1 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding CHZ PF09649.10 EFW98556.1 - 1.7e-14 53.0 1.1 1.7e-14 53.0 1.1 2.1 2 0 0 2 2 2 1 Histone chaperone domain CHZ IL28A PF15177.6 EFW98557.1 - 0.016 15.1 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Interleukin-28A TPR_17 PF13431.6 EFW98557.1 - 0.1 13.0 0.5 0.46 11.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Snf7 PF03357.21 EFW98558.1 - 5.8e-35 120.4 5.6 7e-35 120.2 5.6 1.1 1 0 0 1 1 1 1 Snf7 zf-Tim10_DDP PF02953.15 EFW98559.1 - 1.5e-19 69.4 2.4 1.8e-19 69.1 2.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger WD40 PF00400.32 EFW98560.1 - 2.1e-15 56.9 14.6 4.5e-07 30.5 0.1 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW98560.1 - 0.0066 16.7 0.1 9.1 6.7 0.0 3.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF908 PF06012.12 EFW98561.1 - 9.4e-134 446.3 0.3 9.4e-134 446.3 0.3 3.6 4 0 0 4 4 4 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 EFW98561.1 - 3.3e-127 424.5 0.0 3.3e-127 424.5 0.0 5.0 4 0 0 4 4 4 1 Domain of Unknown Function (DUF913) HECT PF00632.25 EFW98561.1 - 4.5e-91 305.5 0.0 7.4e-91 304.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EFW98561.1 - 2.5e-22 77.5 13.7 6.8e-07 28.5 3.3 4.0 3 0 0 3 3 3 3 Ubiquitin binding region Xpo1 PF08389.12 EFW98561.1 - 0.074 13.1 2.4 15 5.6 0.3 3.6 3 0 0 3 3 3 0 Exportin 1-like protein Arr-ms PF12120.8 EFW98561.1 - 0.2 11.9 1.4 20 5.4 0.1 2.8 2 0 0 2 2 2 0 Rifampin ADP-ribosyl transferase adh_short PF00106.25 EFW98562.1 - 9.9e-47 158.9 0.1 1.2e-46 158.7 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW98562.1 - 1.2e-31 110.0 0.2 1.4e-31 109.8 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW98562.1 - 9.2e-09 35.5 0.5 1.3e-08 35.0 0.5 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFW98562.1 - 0.00022 21.2 0.2 0.00033 20.6 0.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFW98562.1 - 0.013 15.0 0.3 0.039 13.4 0.3 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ApbA PF02558.16 EFW98562.1 - 0.029 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EFW98562.1 - 0.045 13.8 0.0 0.097 12.7 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 EFW98562.1 - 0.1 11.7 0.0 0.25 10.4 0.0 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Ssl1 PF04056.14 EFW98563.1 - 2e-61 207.2 0.0 2.6e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EFW98563.1 - 8.2e-17 61.2 6.9 8.2e-17 61.2 6.9 2.6 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EFW98563.1 - 7.8e-16 58.7 0.0 1.5e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFW98563.1 - 0.042 14.1 0.0 0.062 13.6 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Zn-ribbon_8 PF09723.10 EFW98563.1 - 4.4 7.5 23.0 0.3 11.2 6.7 3.5 3 1 0 3 3 3 0 Zinc ribbon domain NUDE_C PF04880.13 EFW98565.1 - 0.046 14.2 2.2 0.053 14.0 2.2 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region WW PF00397.26 EFW98566.1 - 1.2e-09 38.1 7.3 2e-09 37.4 7.3 1.4 1 0 0 1 1 1 1 WW domain Ribonuc_red_sm PF00268.21 EFW98567.1 - 2e-122 408.1 1.8 2.5e-122 407.7 1.8 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 EFW98567.1 - 0.1 13.4 0.0 0.22 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) p450 PF00067.22 EFW98568.1 - 1.6e-64 218.4 0.0 2e-64 218.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RhaA PF06134.11 EFW98568.1 - 0.083 12.0 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 L-rhamnose isomerase (RhaA) FAD_binding_4 PF01565.23 EFW98569.1 - 8.3e-15 54.7 0.6 8.3e-15 54.7 0.6 1.6 2 0 0 2 2 2 1 FAD binding domain Citrate_synt PF00285.21 EFW98570.1 - 1.3e-101 340.3 0.0 1.7e-101 339.9 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain ORC4_C PF14629.6 EFW98572.1 - 6.8e-70 234.8 0.0 1e-69 234.2 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EFW98572.1 - 2.9e-14 53.8 0.4 1.1e-13 51.9 0.4 2.1 1 0 0 1 1 1 1 AAA ATPase domain PHD PF00628.29 EFW98572.1 - 3.2e-11 42.9 4.5 5.5e-11 42.2 4.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFW98572.1 - 3.5e-11 42.4 2.1 6.3e-11 41.6 2.1 1.4 1 0 0 1 1 1 1 PHD-finger NACHT PF05729.12 EFW98572.1 - 8.2e-06 25.8 0.1 9e-05 22.4 0.0 2.5 2 1 0 2 2 2 1 NACHT domain AAA PF00004.29 EFW98572.1 - 1.9e-05 25.1 0.0 8.1e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFW98572.1 - 3.9e-05 24.0 0.0 0.00012 22.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFW98572.1 - 0.0004 19.6 0.0 0.00067 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) C1_1 PF00130.22 EFW98572.1 - 0.0014 18.5 0.1 0.0032 17.3 0.1 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EFW98572.1 - 0.0048 17.2 2.9 0.0048 17.2 2.9 1.7 2 0 0 2 2 1 1 C1 domain FYVE_2 PF02318.16 EFW98572.1 - 0.0072 16.5 0.4 0.015 15.5 0.4 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger TniB PF05621.11 EFW98572.1 - 0.013 14.9 0.0 0.5 9.8 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 EFW98572.1 - 0.02 15.2 0.3 0.045 14.1 0.1 1.7 2 0 0 2 2 1 0 AAA domain BNIP3 PF06553.12 EFW98572.1 - 0.026 14.2 0.1 0.071 12.8 0.1 1.6 1 0 0 1 1 1 0 BNIP3 NB-ARC PF00931.22 EFW98572.1 - 0.028 13.6 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Prok-RING_1 PF14446.6 EFW98572.1 - 0.078 12.9 4.5 0.16 11.9 4.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 AAA_7 PF12775.7 EFW98572.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFW98572.1 - 0.14 12.2 0.1 0.86 9.6 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Pinin_SDK_N PF04697.13 EFW98572.1 - 6.5 7.4 17.4 0.15 12.7 4.4 3.5 4 0 0 4 4 4 0 pinin/SDK conserved region COX4 PF02936.14 EFW98573.1 - 1.6e-47 161.0 0.1 1.8e-47 160.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1104 PF06518.11 EFW98573.1 - 0.097 13.1 0.4 0.17 12.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) Ni_hydr_CYTB PF01292.20 EFW98573.1 - 0.1 12.2 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Transp_cyt_pur PF02133.15 EFW98574.1 - 1.5e-28 99.8 27.1 1.1e-27 96.9 27.1 1.9 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Phage_holin_1 PF04531.13 EFW98574.1 - 1.6 9.3 6.1 6.7 7.3 0.1 3.1 3 1 0 3 3 3 0 Bacteriophage holin DUF2208 PF09973.9 EFW98574.1 - 4.1 7.0 7.8 0.37 10.4 3.0 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) GFO_IDH_MocA PF01408.22 EFW98575.1 - 1.5e-15 58.1 0.2 3.2e-15 57.0 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_25 PF13649.6 EFW98575.1 - 3.9e-10 40.3 0.6 1.1e-08 35.6 0.1 3.3 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW98575.1 - 5.9e-10 39.7 0.4 4.3e-09 36.9 0.1 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW98575.1 - 0.0055 17.4 0.0 0.023 15.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain F420_oxidored PF03807.17 EFW98575.1 - 0.034 14.7 0.1 0.077 13.6 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Methyltransf_31 PF13847.6 EFW98575.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain HMG_box PF00505.19 EFW98576.1 - 3.7e-25 88.1 0.8 5.3e-25 87.6 0.8 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFW98576.1 - 4e-17 62.6 1.2 5.5e-17 62.1 1.2 1.2 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 EFW98576.1 - 0.0013 19.3 1.6 0.0024 18.4 0.0 1.9 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 CH PF00307.31 EFW98577.1 - 6.6e-48 161.4 0.2 5.1e-23 81.3 0.0 2.8 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EFW98577.1 - 3e-24 84.9 0.1 9.3e-24 83.3 0.0 1.9 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EFW98577.1 - 1.5e-13 50.4 0.2 6.9e-08 32.2 0.1 2.5 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EFW98577.1 - 0.00034 20.3 0.1 0.0018 18.1 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EFW98577.1 - 0.0026 17.6 0.8 0.055 13.3 0.1 2.7 1 1 1 2 2 2 1 EF-hand domain pair UPF0149 PF03695.13 EFW98577.1 - 0.0031 17.8 0.1 0.08 13.2 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0149) EF-hand_7 PF13499.6 EFW98577.1 - 0.0037 17.7 2.2 0.0051 17.2 0.6 2.2 2 0 0 2 2 2 1 EF-hand domain pair CH_2 PF06294.11 EFW98577.1 - 0.0059 16.7 0.0 0.19 11.9 0.0 2.8 3 0 0 3 3 3 1 CH-like domain in sperm protein EF-hand_1 PF00036.32 EFW98577.1 - 0.021 14.3 0.2 0.23 11.1 0.0 2.5 2 0 0 2 2 2 0 EF hand DUF4508 PF14969.6 EFW98577.1 - 0.26 11.5 1.8 9.3 6.6 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) DIL PF01843.19 EFW98578.1 - 1.4e-31 108.8 0.5 3.3e-31 107.6 0.5 1.7 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 EFW98578.1 - 1.8e-22 79.7 0.0 4.1e-13 49.7 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFW98578.1 - 7.3e-13 48.8 0.1 1e-06 29.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFW98578.1 - 2.7e-11 43.5 0.1 2.6e-06 27.6 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFW98578.1 - 8.1e-10 38.7 0.0 0.0042 17.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EFW98578.1 - 1.2e-06 28.4 0.0 0.99 10.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat YL1 PF05764.13 EFW98579.1 - 9.7e-62 209.3 31.2 4.8e-52 177.5 13.1 4.5 5 0 0 5 5 5 2 YL1 nuclear protein YL1_C PF08265.11 EFW98579.1 - 7.1e-13 48.1 0.8 1.2e-12 47.4 0.8 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Calcipressin PF04847.12 EFW98581.1 - 0.17 11.6 1.3 0.33 10.7 1.3 1.4 1 0 0 1 1 1 0 Calcipressin CDC45 PF02724.14 EFW98581.1 - 0.22 9.8 3.0 0.35 9.1 3.0 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 EFW98581.1 - 0.3 11.3 11.4 0.3 11.3 9.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Nucleo_P87 PF07267.11 EFW98581.1 - 0.58 9.0 2.2 0.74 8.6 2.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM176 PF14851.6 EFW98581.1 - 2.1 8.0 4.8 4.9 6.8 4.8 1.6 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EFW98581.1 - 3.1 7.0 6.5 5.2 6.3 6.5 1.3 1 0 0 1 1 1 0 NOA36 protein Spt5_N PF11942.8 EFW98581.1 - 7.6 7.6 14.7 1.3 10.1 10.1 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Tli4_N PF18443.1 EFW98584.1 - 0.9 9.9 6.7 0.27 11.6 2.7 2.2 1 1 1 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain AA_permease PF00324.21 EFW98586.1 - 3e-86 289.9 29.5 3.8e-86 289.6 29.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFW98586.1 - 8.8e-23 80.8 31.3 1.3e-22 80.3 31.3 1.1 1 0 0 1 1 1 1 Amino acid permease NCE101 PF11654.8 EFW98586.1 - 0.01 15.5 0.2 0.024 14.4 0.2 1.6 1 0 0 1 1 1 0 Non-classical export protein 1 TLP1_add_C PF18313.1 EFW98586.1 - 0.083 12.9 0.1 0.52 10.3 0.0 2.2 2 0 0 2 2 2 0 Thiolase-like protein type 1 additional C-terminal domain Mito_carr PF00153.27 EFW98587.1 - 9.9e-56 185.7 0.7 3.7e-20 71.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFW98587.1 - 0.071 12.3 1.5 9.8 5.2 0.2 2.8 1 1 0 2 2 2 0 Gammaproteobacterial serine protease KOW PF00467.29 EFW98588.1 - 0.00024 20.9 0.6 0.00042 20.2 0.6 1.4 1 0 0 1 1 1 1 KOW motif GYF PF02213.16 EFW98589.1 - 7.8e-10 38.3 1.2 1.7e-09 37.2 1.2 1.6 1 0 0 1 1 1 1 GYF domain Gluconate_2-dh3 PF13618.6 EFW98589.1 - 0.014 15.6 0.1 0.032 14.4 0.1 1.6 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 DAO PF01266.24 EFW98590.1 - 2.5e-25 89.8 0.1 3.2e-25 89.5 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase PGM_PMM_I PF02878.16 EFW98591.1 - 2.7e-32 111.4 0.1 3.9e-32 110.8 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EFW98591.1 - 2.1e-24 85.9 0.0 3.5e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EFW98591.1 - 4.9e-16 59.2 0.0 1.3e-15 57.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EFW98591.1 - 3.3e-07 30.4 0.0 7.1e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Amidase PF01425.21 EFW98592.1 - 3e-85 286.9 13.1 8.9e-82 275.4 13.1 3.7 1 1 0 1 1 1 1 Amidase CDC73_C PF05179.14 EFW98593.1 - 5.5e-56 188.6 0.0 7.8e-56 188.1 0.0 1.2 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Amidohydro_2 PF04909.14 EFW98595.1 - 4.2e-16 59.6 9.4 8.1e-16 58.6 9.4 1.4 1 1 0 1 1 1 1 Amidohydrolase Na_H_Exchanger PF00999.21 EFW98596.1 - 3.5e-48 164.3 18.4 4.7e-48 163.9 18.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DprA_WH PF17782.1 EFW98597.1 - 0.091 12.9 3.1 1.6 8.9 0.0 3.5 3 0 0 3 3 3 0 DprA winged helix domain RVT_3 PF13456.6 EFW98597.1 - 0.45 10.3 2.9 0.44 10.4 0.5 2.1 2 0 0 2 2 2 0 Reverse transcriptase-like LSM PF01423.22 EFW98598.1 - 1.8e-13 49.9 0.0 3.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 LSM domain DUF2892 PF11127.8 EFW98599.1 - 0.3 11.1 8.9 0.4 10.8 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) VTC PF09359.10 EFW98600.1 - 8.2e-85 284.5 0.0 3.9e-84 282.3 0.0 2.0 2 0 0 2 2 2 1 VTC domain SPX PF03105.19 EFW98600.1 - 2.5e-11 44.1 7.8 8.1e-06 26.0 0.1 3.2 1 1 1 3 3 3 2 SPX domain DUF202 PF02656.15 EFW98600.1 - 8.7e-11 42.1 3.9 8.7e-11 42.1 3.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) MgtE PF01769.16 EFW98600.1 - 0.045 14.1 0.7 0.074 13.4 0.7 1.3 1 0 0 1 1 1 0 Divalent cation transporter Pkinase PF00069.25 EFW98602.1 - 3.7e-64 216.6 0.0 7.1e-64 215.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW98602.1 - 3.5e-37 128.1 0.0 3.5e-31 108.4 0.1 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFW98602.1 - 7.6e-08 32.0 0.0 0.00016 21.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EFW98602.1 - 4.9e-05 23.4 0.1 0.00074 19.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFW98602.1 - 0.0052 15.8 0.4 0.013 14.4 0.4 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFW98602.1 - 0.0098 15.3 0.3 0.025 13.9 0.3 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFW98602.1 - 0.073 12.7 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 RIO1 family ketoacyl-synt PF00109.26 EFW98603.1 - 2.3e-52 178.1 0.0 2.7e-49 168.1 0.0 2.2 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFW98603.1 - 2.9e-39 133.7 0.1 1e-38 131.9 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFW98603.1 - 7.4e-13 48.9 0.0 1.4e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Acyl_transf_1 PF00698.21 EFW98603.1 - 1.7e-06 27.8 0.2 2.3e-06 27.3 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain MOFRL PF05161.13 EFW98603.1 - 0.019 15.2 0.3 0.088 13.0 0.2 2.1 2 0 0 2 2 2 0 MOFRL family 4F5 PF04419.14 EFW98604.1 - 1.6e-08 35.2 16.2 1.6e-08 35.2 16.2 2.2 2 0 0 2 2 2 1 4F5 protein family Cys_Met_Meta_PP PF01053.20 EFW98606.1 - 2.7e-101 338.9 0.0 4.6e-81 272.3 0.0 3.0 1 1 2 3 3 3 3 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFW98606.1 - 3.3e-13 49.6 0.0 5e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFW98606.1 - 8.5e-11 41.4 0.1 1.3e-10 40.8 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFW98606.1 - 2.2e-06 27.2 0.2 4.2e-06 26.3 0.2 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SepSecS PF05889.13 EFW98606.1 - 0.035 12.8 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GDC-P PF02347.16 EFW98606.1 - 0.043 12.6 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 EFW98606.1 - 0.06 12.6 0.3 0.73 9.1 0.3 2.2 1 1 0 1 1 1 0 Beta-eliminating lyase Sugar_tr PF00083.24 EFW98607.1 - 2.1e-75 254.3 20.6 2.7e-75 254.0 20.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Pribosyltran_N PF13793.6 EFW98607.1 - 2.6e-39 133.8 0.2 5.7e-39 132.7 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase MFS_1 PF07690.16 EFW98607.1 - 9.8e-30 103.7 22.1 1.8e-29 102.8 22.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Pribosyl_synth PF14572.6 EFW98607.1 - 1.7e-26 93.4 3.3 4.6e-24 85.5 2.3 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFW98607.1 - 1.3e-06 28.1 0.2 3.1e-06 26.8 0.2 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain TRI12 PF06609.13 EFW98607.1 - 0.0032 16.0 2.8 0.0032 16.0 2.8 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) BT1 PF03092.16 EFW98607.1 - 0.0064 14.8 0.2 0.0064 14.8 0.2 1.6 2 0 0 2 2 2 1 BT1 family MFS_5 PF05631.14 EFW98607.1 - 0.017 14.1 11.1 0.0096 14.9 1.8 2.6 2 1 1 3 3 3 0 Sugar-tranasporters, 12 TM OATP PF03137.20 EFW98607.1 - 0.87 7.8 12.4 0.05 11.9 0.5 3.0 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family GMC_oxred_N PF00732.19 EFW98608.1 - 3.2e-60 204.0 0.0 8.2e-60 202.7 0.0 1.6 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFW98608.1 - 1.8e-31 109.6 0.0 3.3e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EFW98608.1 - 0.018 14.7 0.6 0.11 12.0 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFW98608.1 - 0.022 13.8 0.2 0.022 13.8 0.2 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFW98608.1 - 0.032 14.5 1.0 0.073 13.3 0.1 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EFW98608.1 - 0.034 13.0 0.1 0.047 12.5 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EFW98608.1 - 0.15 11.3 0.6 0.29 10.3 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Lac_bphage_repr PF06543.12 EFW98608.1 - 1.7 8.7 5.2 3.4 7.7 5.2 1.4 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor UFD1 PF03152.14 EFW98609.1 - 1e-65 220.4 0.0 1.3e-65 220.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DAO PF01266.24 EFW98610.1 - 1.9e-51 175.7 0.1 2.8e-51 175.2 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EFW98610.1 - 5.7e-40 136.1 0.0 1.1e-39 135.2 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EFW98610.1 - 3.6e-07 29.6 2.2 2.2e-06 27.0 2.2 2.1 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFW98610.1 - 0.001 18.5 0.4 0.016 14.6 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFW98610.1 - 0.0049 17.1 0.3 0.031 14.5 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW98610.1 - 0.01 15.1 0.1 0.022 14.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFW98610.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFW98610.1 - 0.028 13.7 0.5 0.59 9.3 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain Ldl_recept_b PF00058.17 EFW98610.1 - 0.034 14.6 0.1 0.32 11.5 0.0 2.3 2 0 0 2 2 2 0 Low-density lipoprotein receptor repeat class B Lycopene_cycl PF05834.12 EFW98610.1 - 0.036 13.1 0.1 0.88 8.6 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EFW98610.1 - 0.045 13.6 0.2 0.095 12.6 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EFW98610.1 - 0.096 11.4 0.3 0.14 10.8 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 EFW98610.1 - 0.16 11.2 0.9 0.51 9.5 0.1 2.0 2 0 0 2 2 2 0 Thi4 family TruD PF01142.18 EFW98611.1 - 1.5e-62 211.8 0.0 2.3e-57 194.7 0.0 3.4 3 1 0 3 3 3 3 tRNA pseudouridine synthase D (TruD) HATPase_c_3 PF13589.6 EFW98612.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFW98612.1 - 0.13 12.8 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DEAD PF00270.29 EFW98613.1 - 2.8e-39 134.7 0.0 5.6e-39 133.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW98613.1 - 1.6e-28 99.3 0.0 2.9e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW98613.1 - 0.00035 20.6 0.0 0.00065 19.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFW98613.1 - 0.012 14.3 0.0 0.016 13.9 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain LSDAT_prok PF18171.1 EFW98613.1 - 0.099 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote SWI2_SNF2 PF18766.1 EFW98613.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Pro-kuma_activ PF09286.11 EFW98614.1 - 1.8e-43 148.3 0.0 3.2e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFW98614.1 - 0.00061 19.1 0.2 0.0013 18.1 0.2 1.5 1 0 0 1 1 1 1 Subtilase family CLASP_N PF12348.8 EFW98616.1 - 1.9e-127 423.4 0.4 1.3e-87 293.1 0.0 2.2 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 EFW98616.1 - 0.0019 18.3 0.2 9.7 6.8 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat Rgp1 PF08737.10 EFW98617.1 - 1.5e-143 479.0 0.4 7.1e-143 476.7 0.0 2.3 2 1 0 2 2 2 1 Rgp1 Ribonuclease_3 PF00636.26 EFW98617.1 - 4.9e-33 113.9 0.0 2.9e-18 66.4 0.0 3.0 2 1 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFW98617.1 - 4.2e-20 72.2 0.1 1.8e-10 41.0 0.0 3.6 2 1 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EFW98617.1 - 3.7e-19 68.7 0.0 1.1e-18 67.1 0.0 1.9 1 0 0 1 1 1 1 Dicer dimerisation domain DEAD PF00270.29 EFW98617.1 - 3.6e-13 49.7 0.0 7.6e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW98617.1 - 5.7e-10 39.5 0.0 1.5e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW98617.1 - 7.9e-10 39.0 0.0 2e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FliX PF10768.9 EFW98617.1 - 9.3 6.8 13.8 2.7 8.5 3.5 3.1 2 0 0 2 2 2 0 Class II flagellar assembly regulator HATPase_c PF02518.26 EFW98618.1 - 1.3e-25 90.1 0.0 2.7e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 EFW98618.1 - 8.1e-23 80.5 2.3 6.3e-14 52.0 0.8 3.6 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 EFW98618.1 - 9.8e-20 70.4 0.1 2.3e-19 69.2 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EFW98618.1 - 1.4e-19 70.3 0.0 3.7e-19 69.0 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS PF00989.25 EFW98618.1 - 9.6e-10 38.5 0.0 0.00022 21.2 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 EFW98618.1 - 2.5e-08 34.1 0.4 3e-06 27.5 0.2 3.1 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EFW98618.1 - 2.2e-07 31.1 0.0 0.0099 16.1 0.0 3.0 2 1 0 2 2 2 2 PAS domain PAS_8 PF13188.7 EFW98618.1 - 0.025 14.6 0.0 2.2 8.4 0.0 2.6 2 0 0 2 2 2 0 PAS domain SCO1-SenC PF02630.14 EFW98619.1 - 3.4e-49 166.2 0.0 4.5e-49 165.8 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EFW98619.1 - 0.00037 20.4 0.0 0.00076 19.4 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFW98619.1 - 0.055 13.2 0.0 4.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Redoxin RPN6_N PF18055.1 EFW98620.1 - 1.2e-45 154.7 0.9 1.2e-45 154.7 0.9 2.1 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EFW98620.1 - 2.7e-19 69.6 0.1 7.3e-19 68.2 0.1 1.8 1 0 0 1 1 1 1 PCI domain Neugrin PF06413.11 EFW98620.1 - 2e-12 47.6 0.7 2e-12 47.6 0.7 2.0 2 0 0 2 2 2 1 Neugrin RPN6_C_helix PF18503.1 EFW98620.1 - 8e-11 41.5 0.5 1.7e-10 40.4 0.5 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain MRP-L20 PF12824.7 EFW98620.1 - 1.7e-05 25.1 1.5 5e-05 23.5 1.5 1.9 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 DDRGK PF09756.9 EFW98620.1 - 0.00042 20.0 0.3 0.00042 20.0 0.3 2.0 2 0 0 2 2 2 1 DDRGK domain ASFV_J13L PF05568.11 EFW98620.1 - 0.0019 18.0 5.0 0.0048 16.7 5.0 1.7 1 0 0 1 1 1 1 African swine fever virus J13L protein HTH_Crp_2 PF13545.6 EFW98620.1 - 0.043 13.8 0.4 0.3 11.1 0.0 2.6 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain TPR_7 PF13176.6 EFW98620.1 - 0.048 13.7 5.3 11 6.4 1.3 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EFW98620.1 - 0.22 11.8 0.9 0.72 10.2 0.5 2.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_10 PF13374.6 EFW98620.1 - 4.1 7.4 9.3 35 4.4 0.2 5.7 7 0 0 7 7 7 0 Tetratricopeptide repeat Glyco_hydro_64 PF16483.5 EFW98621.1 - 3.5e-132 441.1 5.3 4.6e-132 440.8 5.3 1.1 1 0 0 1 1 1 1 Beta-1,3-glucanase HEV_ORF1 PF02444.16 EFW98621.1 - 1.8 9.2 9.7 0.3 11.6 3.6 2.7 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) AAA_lid_3 PF17862.1 EFW98622.1 - 8.9e-07 28.6 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain LSM PF01423.22 EFW98624.1 - 7.1e-20 70.5 0.0 8.1e-20 70.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFW98624.1 - 0.00041 20.4 0.1 0.00045 20.3 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EFW98624.1 - 0.00082 19.4 0.1 0.001 19.1 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain FAD_binding_1 PF00667.20 EFW98625.1 - 2.9e-63 213.4 0.0 4.1e-63 212.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFW98625.1 - 5e-35 120.8 0.5 1e-34 119.8 0.5 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFW98625.1 - 4e-20 72.5 0.0 3e-19 69.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Choline_transpo PF04515.12 EFW98626.1 - 6.2e-29 101.2 13.3 6.2e-29 101.2 13.3 2.7 2 2 1 3 3 3 1 Plasma-membrane choline transporter DUF872 PF05915.12 EFW98626.1 - 1.5 9.0 5.1 0.33 11.1 0.6 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Ribosomal_L7Ae PF01248.26 EFW98628.1 - 1e-27 95.7 0.7 1.3e-27 95.4 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EFW98628.1 - 0.075 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Pkinase PF00069.25 EFW98630.1 - 3.6e-57 193.7 0.0 5.4e-57 193.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW98630.1 - 6.4e-32 110.9 0.0 1.6e-30 106.2 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFW98630.1 - 0.0013 17.7 0.0 0.002 17.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EFW98630.1 - 0.011 14.8 0.0 0.016 14.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EFW98630.1 - 0.13 11.6 0.3 0.26 10.6 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SURF1 PF02104.15 EFW98631.1 - 6.8e-41 140.4 0.0 9.1e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 SURF1 family RRM_1 PF00076.22 EFW98632.1 - 2.4e-60 200.3 0.0 1.1e-20 73.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFW98632.1 - 1.2e-10 41.0 0.0 0.0028 17.5 0.0 3.4 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EFW98632.1 - 1.6e-09 37.4 0.0 1.5e-06 27.8 0.0 3.0 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFW98632.1 - 5.4e-07 29.5 0.1 0.12 12.4 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 EFW98632.1 - 0.00034 20.6 0.0 0.47 10.6 0.0 2.4 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_7 PF16367.5 EFW98632.1 - 0.00065 19.8 0.1 0.62 10.2 0.0 3.3 3 1 0 3 3 3 1 RNA recognition motif RRM_8 PF11835.8 EFW98632.1 - 0.00092 19.4 0.0 0.37 11.0 0.0 2.4 2 0 0 2 2 2 2 RRM-like domain RNA_bind PF08675.11 EFW98632.1 - 0.043 13.8 0.0 1.6 8.8 0.0 2.5 2 0 0 2 2 2 0 RNA binding domain RRM_3 PF08777.11 EFW98632.1 - 0.056 13.5 0.0 0.51 10.4 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif SET_assoc PF11767.8 EFW98632.1 - 0.17 11.6 0.0 18 5.0 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Ras PF00071.22 EFW98633.1 - 6.6e-44 149.4 0.1 8.4e-44 149.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFW98633.1 - 4e-11 43.2 0.0 6.3e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFW98633.1 - 3.1e-05 23.5 0.1 3.7e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFW98633.1 - 7.5e-05 22.3 0.0 9.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFW98633.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase BTB PF00651.31 EFW98634.1 - 2.9e-05 24.3 0.0 4.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Hormone_2 PF00123.20 EFW98634.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 Peptide hormone ATP_synt_H PF05493.13 EFW98635.1 - 6.1e-24 84.3 1.6 6.9e-24 84.1 1.6 1.0 1 0 0 1 1 1 1 ATP synthase subunit H YfhO PF09586.10 EFW98635.1 - 0.032 12.5 0.3 0.032 12.5 0.3 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SE PF08491.10 EFW98636.1 - 8.7e-95 316.9 0.0 1.1e-94 316.6 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EFW98636.1 - 4e-13 49.3 0.0 5.3e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFW98636.1 - 4e-09 36.5 0.6 7e-06 25.8 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 EFW98636.1 - 0.00015 20.9 0.1 0.16 11.0 0.1 2.0 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EFW98636.1 - 0.00053 20.2 0.4 0.0012 19.0 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFW98636.1 - 0.0016 17.9 0.4 0.0023 17.4 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EFW98636.1 - 0.0019 18.2 0.0 0.0033 17.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EFW98636.1 - 0.0023 17.8 0.1 0.0047 16.8 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EFW98636.1 - 0.0028 16.8 1.4 0.023 13.8 0.6 2.0 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 EFW98636.1 - 0.0042 16.0 0.4 1 8.1 0.3 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 EFW98636.1 - 0.005 16.8 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_2 PF07992.14 EFW98636.1 - 0.0078 15.5 0.3 0.016 14.4 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFW98636.1 - 0.0089 15.3 0.0 0.019 14.2 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EFW98636.1 - 0.041 14.4 0.8 0.084 13.4 0.1 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFW98636.1 - 0.094 11.8 0.2 0.19 10.8 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 EFW98636.1 - 0.096 13.0 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain adh_short PF00106.25 EFW98636.1 - 0.11 12.0 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase ApbA PF02558.16 EFW98636.1 - 0.11 12.1 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EFW98636.1 - 0.11 12.7 0.5 0.21 11.9 0.1 1.6 2 0 0 2 2 1 0 Saccharopine dehydrogenase NADP binding domain HI0933_like PF03486.14 EFW98636.1 - 0.15 10.7 0.2 0.22 10.2 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein RNase_H PF00075.24 EFW98637.1 - 6.5e-35 120.4 0.0 1.5e-34 119.2 0.0 1.6 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EFW98637.1 - 4.8e-28 97.2 16.3 4.8e-15 55.6 1.2 3.9 4 0 0 4 4 4 2 Caulimovirus viroplasmin dCMP_cyt_deam_1 PF00383.23 EFW98637.1 - 1.6e-09 37.6 0.2 5.8e-07 29.3 0.2 3.5 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFW98637.1 - 1.7e-06 27.8 0.4 5.2e-05 23.0 0.1 2.4 2 0 0 2 2 2 1 MafB19-like deaminase DUF4611 PF15387.6 EFW98637.1 - 0.051 13.8 10.3 0.023 14.9 7.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 EFW98637.1 - 0.083 12.2 2.5 0.17 11.2 2.5 1.4 1 0 0 1 1 1 0 NOA36 protein L-fibroin PF05849.11 EFW98637.1 - 0.089 12.1 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) Bd3614-deam PF14439.6 EFW98637.1 - 0.14 12.3 0.0 0.14 12.3 0.0 2.4 3 0 0 3 3 2 0 Bd3614-like deaminase Cnd2 PF05786.14 EFW98637.1 - 0.2 10.3 2.2 0.38 9.4 2.2 1.4 1 0 0 1 1 1 0 Condensin complex subunit 2 FAM176 PF14851.6 EFW98637.1 - 0.27 10.9 1.9 0.7 9.6 1.9 1.6 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 EFW98637.1 - 0.43 8.6 3.4 3.4 5.6 2.2 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 EFW98637.1 - 0.57 8.2 4.4 0.86 7.6 4.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_60s PF00428.19 EFW98637.1 - 0.97 10.1 20.1 0.13 12.9 10.2 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein Radial_spoke PF04712.12 EFW98637.1 - 1.6 7.6 6.0 2.9 6.7 6.0 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein Ank_2 PF12796.7 EFW98638.1 - 2.4e-53 178.6 0.0 1.8e-12 47.6 0.0 6.0 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFW98638.1 - 1e-36 124.5 2.5 2.1e-07 31.1 0.0 7.2 3 1 6 9 9 9 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFW98638.1 - 1.6e-35 121.0 0.0 1.7e-08 34.8 0.0 6.8 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EFW98638.1 - 3e-35 119.1 0.2 0.0051 17.2 0.0 10.1 10 0 0 10 10 10 9 Ankyrin repeat Ank_3 PF13606.6 EFW98638.1 - 3.1e-35 116.2 0.0 0.0031 17.9 0.0 11.0 10 0 0 10 10 10 7 Ankyrin repeat AAA_16 PF13191.6 EFW98638.1 - 8.7e-06 26.2 0.1 4.8e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EFW98638.1 - 0.00011 22.2 0.2 0.00029 20.8 0.2 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFW98638.1 - 0.0049 17.1 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFW98638.1 - 0.032 14.0 0.0 0.093 12.5 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain RRM_1 PF00076.22 EFW98639.1 - 7e-20 70.6 0.4 3.3e-12 46.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4692 PF15763.5 EFW98640.1 - 1.1 9.7 4.9 0.26 11.8 1.2 1.9 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) LSM PF01423.22 EFW98641.1 - 4.5e-11 42.3 0.0 6.1e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFW98641.1 - 0.0013 18.8 0.0 0.0022 18.1 0.0 1.5 1 1 0 1 1 1 1 Ataxin 2 SM domain DUF2642 PF10842.8 EFW98641.1 - 0.024 14.5 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) tRNA-synt_2 PF00152.20 EFW98644.1 - 1.8e-58 198.1 0.0 2.2e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFW98644.1 - 2.4e-11 43.4 0.0 4.8e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFW98644.1 - 9.3e-05 22.0 0.0 0.013 15.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DUF2293 PF10056.9 EFW98645.1 - 9.7e-24 83.4 0.1 9.7e-24 83.4 0.1 2.4 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2293) DCP2 PF05026.13 EFW98647.1 - 1.6e-28 98.8 0.4 2.9e-28 98.0 0.4 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EFW98647.1 - 4.4e-16 59.1 0.0 8.5e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.6 EFW98648.1 - 8.9e-37 125.6 0.5 1.2e-36 125.1 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) GFO_IDH_MocA PF01408.22 EFW98649.1 - 7.5e-14 52.6 0.2 6.1e-13 49.7 0.2 2.2 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFW98649.1 - 0.00048 20.1 0.3 0.0017 18.4 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain ImpA_N PF06812.12 EFW98649.1 - 0.015 15.4 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system AAA PF00004.29 EFW98650.1 - 4.8e-18 65.9 0.0 8.3e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFW98650.1 - 0.00015 22.1 0.1 0.00056 20.2 0.1 1.9 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EFW98650.1 - 0.00021 21.3 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFW98650.1 - 0.00049 20.5 0.0 0.0011 19.3 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFW98650.1 - 0.0027 18.3 0.0 0.0097 16.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFW98650.1 - 0.013 15.6 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RCR PF12273.8 EFW98650.1 - 0.014 16.0 6.0 0.035 14.8 6.0 1.6 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red RuvB_N PF05496.12 EFW98650.1 - 0.026 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 EFW98650.1 - 0.047 14.1 0.1 0.17 12.3 0.1 2.0 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFW98650.1 - 0.12 11.5 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain MeaB PF03308.16 EFW98650.1 - 0.17 10.8 0.1 3 6.7 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB YfhD PF14151.6 EFW98650.1 - 0.19 11.9 0.0 0.19 11.9 0.0 3.1 3 0 0 3 3 2 0 YfhD-like protein Hydin_ADK PF17213.3 EFW98650.1 - 0.22 11.8 3.3 0.36 11.1 0.0 2.5 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_28 PF13521.6 EFW98650.1 - 0.35 11.1 1.9 0.56 10.4 0.1 2.3 3 0 0 3 3 3 0 AAA domain FTZ PF03867.14 EFW98650.1 - 0.47 10.0 3.4 0.76 9.3 3.4 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DivIC PF04977.15 EFW98651.1 - 0.0096 15.7 4.1 0.0096 15.7 4.1 5.0 5 1 0 5 5 5 1 Septum formation initiator DUF1664 PF07889.12 EFW98651.1 - 0.015 15.3 17.3 0.22 11.6 2.9 4.1 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) ARTD15_N PF18084.1 EFW98651.1 - 0.073 13.3 1.2 5.7 7.3 0.1 3.7 3 1 0 3 3 3 0 ARTD15 N-terminal domain Lectin_N PF03954.14 EFW98651.1 - 0.16 11.7 0.1 0.16 11.7 0.1 4.4 3 2 0 3 3 3 0 Hepatic lectin, N-terminal domain Arm-DNA-bind_5 PF17293.2 EFW98651.1 - 0.6 10.6 3.2 18 5.9 0.5 2.9 2 0 0 2 2 2 0 Arm DNA-binding domain NPV_P10 PF05531.12 EFW98651.1 - 0.7 10.4 23.9 1.8 9.1 0.2 6.0 5 2 2 7 7 7 0 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 EFW98651.1 - 3.4 7.8 10.2 0.63 10.2 1.6 4.3 4 1 0 4 4 4 0 bZIP transcription factor DASH_Dad3 PF08656.10 EFW98651.1 - 4.4 7.5 8.6 1.6 8.9 0.1 4.1 3 2 1 4 4 4 0 DASH complex subunit Dad3 ZapB PF06005.12 EFW98651.1 - 5.2 7.6 22.5 0.42 11.1 6.0 5.1 4 2 1 5 5 5 0 Cell division protein ZapB BLOC1_2 PF10046.9 EFW98651.1 - 5.4 7.4 20.9 2 8.8 3.2 5.9 4 2 3 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AnmK PF03702.14 EFW98652.1 - 9.2e-57 192.8 0.0 1.8e-56 191.8 0.0 1.5 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase SIS PF01380.22 EFW98652.1 - 1.6e-05 24.8 0.4 0.00011 22.0 0.0 2.3 2 0 0 2 2 2 1 SIS domain SIS_2 PF13580.6 EFW98652.1 - 1.7e-05 24.9 0.4 0.0001 22.3 0.4 2.3 1 1 0 1 1 1 1 SIS domain Catalase PF00199.19 EFW98653.1 - 1e-167 558.1 0.2 1.6e-102 343.5 0.2 2.0 1 1 1 2 2 2 2 Catalase Catalase-rel PF06628.12 EFW98653.1 - 5.6e-13 48.9 0.0 1.3e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive CLTH PF10607.9 EFW98654.1 - 6.4e-34 117.0 0.0 1.1e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EFW98654.1 - 7.3e-07 29.1 0.4 1.3e-06 28.3 0.4 1.4 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EFW98654.1 - 0.001 18.5 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_5 PF14634.6 EFW98654.1 - 0.003 17.5 0.3 0.005 16.8 0.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFW98654.1 - 0.0052 17.1 0.6 0.0091 16.3 0.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFW98654.1 - 0.025 14.4 0.8 0.048 13.6 0.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1759 PF03564.15 EFW98654.1 - 0.079 12.9 0.4 0.56 10.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) zf-C3HC4_3 PF13920.6 EFW98654.1 - 0.22 11.4 0.3 0.41 10.5 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PALP PF00291.25 EFW98655.1 - 1.1e-66 225.2 0.4 1.6e-66 224.7 0.4 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Use1 PF09753.9 EFW98656.1 - 0.001 18.8 0.0 0.0012 18.6 0.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Ank_5 PF13857.6 EFW98657.1 - 2.6e-17 62.6 0.3 2e-13 50.3 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeats (many copies) VPS9 PF02204.18 EFW98657.1 - 4.9e-17 62.0 0.0 1.1e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_2 PF12796.7 EFW98657.1 - 6.5e-12 45.9 0.0 0.00083 19.9 0.0 3.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFW98657.1 - 5.8e-09 36.3 0.0 0.053 14.1 0.0 5.5 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW98657.1 - 5.8e-08 32.4 0.1 0.28 11.9 0.0 5.5 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EFW98657.1 - 0.0028 18.0 0.1 15 6.3 0.0 4.6 5 0 0 5 5 5 1 Ankyrin repeat Arv1 PF04161.13 EFW98658.1 - 2.1e-75 253.5 0.0 3e-75 253.0 0.0 1.2 1 0 0 1 1 1 1 Arv1-like family FAM199X PF15814.5 EFW98658.1 - 4.5 6.2 7.2 6.7 5.7 7.2 1.1 1 0 0 1 1 1 0 Protein family FAM199X Chs7 PF12271.8 EFW98659.1 - 1.8e-100 336.0 7.6 2.2e-100 335.7 7.6 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone CUE PF02845.16 EFW98660.1 - 7.1e-11 41.6 0.0 1.3e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 CUE domain TetR_C_16 PF17920.1 EFW98660.1 - 0.43 10.8 3.9 0.16 12.2 0.4 2.1 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Calcipressin PF04847.12 EFW98661.1 - 2.4e-43 148.1 0.3 5.4e-43 146.9 0.3 1.6 1 1 0 1 1 1 1 Calcipressin TrkH PF02386.16 EFW98663.1 - 6.1e-143 476.9 10.9 3.1e-142 474.6 7.5 2.1 2 0 0 2 2 2 2 Cation transport protein RPN1_RPN2_N PF17781.1 EFW98665.1 - 3e-116 388.2 5.7 5.3e-116 387.3 5.7 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EFW98665.1 - 1.1e-29 102.3 0.0 2e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EFW98665.1 - 1.1e-19 69.8 18.8 1.4e-05 25.3 0.2 8.9 9 1 0 9 9 9 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFW98665.1 - 8.8e-07 29.2 1.0 0.069 13.5 0.0 4.2 5 1 1 6 6 6 3 HEAT repeats Pinin_SDK_memA PF04696.13 EFW98665.1 - 0.17 11.9 1.4 0.4 10.8 1.4 1.5 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region RbpA PF13397.6 EFW98665.1 - 0.22 12.1 0.4 0.5 11.0 0.4 1.6 1 0 0 1 1 1 0 RNA polymerase-binding protein TPT PF03151.16 EFW98666.1 - 2.9e-57 194.2 7.7 3.6e-57 193.9 7.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFW98666.1 - 4.8e-09 36.5 30.1 1.5e-05 25.2 10.4 3.3 2 2 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFW98666.1 - 0.0005 19.4 12.5 0.0017 17.6 12.5 1.8 1 1 0 1 1 1 1 UAA transporter family Transp_cyt_pur PF02133.15 EFW98667.1 - 2.9e-47 161.5 26.4 4.1e-47 161.0 26.4 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PetL PF05115.14 EFW98667.1 - 1.1 9.3 6.3 8.6 6.4 0.1 4.0 3 0 0 3 3 3 0 Cytochrome B6-F complex subunit VI (PetL) DUF4131 PF13567.6 EFW98667.1 - 2.7 7.6 6.2 1.9 8.2 2.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) AAA_18 PF13238.6 EFW98668.1 - 2.8e-05 24.6 2.1 0.00014 22.4 0.2 2.6 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFW98668.1 - 0.063 13.4 0.4 0.24 11.5 0.4 2.1 1 1 0 1 1 1 0 AAA domain EPSP_synthase PF00275.20 EFW98669.1 - 6.9e-130 433.5 0.0 1.2e-129 432.7 0.0 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EFW98669.1 - 3.7e-103 344.2 0.0 5.7e-103 343.6 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EFW98669.1 - 2.2e-59 201.5 0.0 3.9e-59 200.7 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EFW98669.1 - 1.3e-33 116.3 0.0 3.6e-32 111.7 0.0 2.3 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 EFW98669.1 - 8.4e-23 80.4 0.0 2.4e-22 79.0 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.6 EFW98669.1 - 5.3e-08 32.9 0.1 1.6e-07 31.3 0.1 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase SDH_C PF18317.1 EFW98669.1 - 3.9e-07 29.7 2.0 7.7e-07 28.8 1.1 2.0 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain AAA_33 PF13671.6 EFW98669.1 - 0.028 14.6 0.0 0.067 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Hydrolase PF00702.26 EFW98670.1 - 7.6e-06 26.4 0.0 4e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFW98670.1 - 0.0046 17.1 0.0 0.0064 16.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Mitofilin PF09731.9 EFW98671.1 - 1.9e-137 459.8 16.6 4.9e-136 455.1 16.6 2.0 1 1 0 1 1 1 1 Mitochondrial inner membrane protein Rotamase PF00639.21 EFW98671.1 - 4 8.5 5.3 12 7.0 0.0 3.1 3 0 0 3 3 3 0 PPIC-type PPIASE domain UDPG_MGDP_dh PF00984.19 EFW98672.1 - 3.2e-30 104.2 0.0 7e-30 103.1 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EFW98672.1 - 3e-22 79.0 0.0 6.9e-18 65.0 0.0 2.5 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh_N PF03721.14 EFW98672.1 - 3.9e-22 78.7 0.0 9.2e-22 77.5 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF4173 PF13777.6 EFW98673.1 - 0.024 14.1 1.2 0.035 13.5 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) zf-RING_2 PF13639.6 EFW98674.1 - 1e-12 48.2 4.4 1.7e-12 47.4 4.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFW98674.1 - 2.3e-10 40.0 1.6 4.3e-10 39.1 1.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFW98674.1 - 7.3e-07 28.9 4.3 1.2e-06 28.2 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFW98674.1 - 1.2e-06 28.2 3.2 2.3e-06 27.4 3.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFW98674.1 - 4.1e-06 27.0 5.1 1.2e-05 25.5 5.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFW98674.1 - 1.4e-05 24.8 3.4 2.6e-05 24.0 3.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFW98674.1 - 5.6e-05 23.0 1.9 9.7e-05 22.3 1.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFW98674.1 - 0.0028 17.5 1.8 0.0056 16.5 1.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFW98674.1 - 0.0029 17.6 0.8 0.0057 16.7 0.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFW98674.1 - 0.02 14.9 5.5 0.044 13.8 5.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 EFW98674.1 - 0.044 13.6 2.4 0.092 12.6 2.4 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EFW98674.1 - 0.047 14.0 2.2 0.082 13.2 2.2 1.4 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 EFW98674.1 - 0.37 10.7 2.5 0.89 9.5 2.5 1.7 1 0 0 1 1 1 0 PHD-finger ANAPC4_WD40 PF12894.7 EFW98675.1 - 1.9e-07 31.3 0.1 0.35 11.2 0.0 4.3 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFW98675.1 - 0.032 15.1 7.9 0.29 12.1 0.1 5.0 5 1 1 6 6 6 0 WD domain, G-beta repeat GrpE PF01025.19 EFW98676.1 - 1.1e-45 155.3 4.5 1.1e-45 155.2 3.3 1.6 1 1 0 1 1 1 1 GrpE BSP PF04450.12 EFW98677.1 - 5.2e-76 255.0 0.0 9.6e-76 254.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase of plants and bacteria ETC_C1_NDUFA5 PF04716.14 EFW98677.1 - 7.2e-23 80.2 0.4 7.2e-23 80.2 0.4 2.9 3 0 0 3 3 3 1 ETC complex I subunit conserved region RNA_pol_I_TF PF04090.12 EFW98677.1 - 0.026 14.0 0.0 0.2 11.1 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase I specific initiation factor CNDH2_C PF16858.5 EFW98677.1 - 2 8.2 25.2 0.32 10.8 1.1 3.4 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term BUD22 PF09073.10 EFW98679.1 - 7.3 5.8 24.4 11 5.3 24.4 1.3 1 0 0 1 1 1 0 BUD22 zinc_ribbon_6 PF14599.6 EFW98680.1 - 2.7e-24 85.0 0.5 2.7e-24 85.0 0.5 3.8 3 2 2 5 5 5 1 Zinc-ribbon zf-CHY PF05495.12 EFW98680.1 - 2.8e-18 66.2 22.2 2.8e-18 66.2 22.2 3.0 2 1 1 3 3 3 2 CHY zinc finger zf-RING_2 PF13639.6 EFW98680.1 - 4.7e-06 26.8 6.1 4.7e-06 26.8 6.1 4.2 4 1 1 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 EFW98680.1 - 0.0045 16.9 11.6 0.0045 16.9 11.6 4.3 4 1 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFW98680.1 - 0.0046 16.8 8.2 0.0046 16.8 8.2 4.3 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2_4 PF13894.6 EFW98680.1 - 0.31 12.0 0.1 0.31 12.0 0.1 5.6 7 0 0 7 7 7 0 C2H2-type zinc finger WD40 PF00400.32 EFW98681.1 - 1.5e-12 47.8 12.0 0.0017 19.1 0.1 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat MraZ PF02381.18 EFW98681.1 - 0.01 15.8 0.0 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like TFIIF_alpha PF05793.12 EFW98681.1 - 0.18 10.4 13.9 0.25 9.9 13.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cwf_Cwc_15 PF04889.12 EFW98681.1 - 3.4 7.3 14.2 8.2 6.1 14.2 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 EFW98681.1 - 5.8 4.9 9.8 8.9 4.3 9.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAD_binding_3 PF01494.19 EFW98682.1 - 1.4e-08 34.4 0.2 0.0016 17.8 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EFW98682.1 - 2.7e-06 27.5 0.2 6.2e-06 26.3 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFW98682.1 - 0.00074 20.0 0.3 0.0017 18.9 0.3 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFW98682.1 - 0.00084 18.7 0.1 0.0012 18.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFW98682.1 - 0.0077 15.8 0.3 0.016 14.8 0.3 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFW98682.1 - 0.018 15.1 0.1 0.068 13.2 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 EFW98682.1 - 0.028 14.4 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_2 PF00890.24 EFW98682.1 - 0.055 12.5 1.5 0.079 12.0 0.9 1.6 1 1 1 2 2 2 0 FAD binding domain Thi4 PF01946.17 EFW98682.1 - 0.056 12.7 0.0 0.099 11.9 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EFW98682.1 - 0.069 12.2 0.1 0.12 11.4 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EFW98682.1 - 0.088 12.1 0.1 0.12 11.7 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EFW98683.1 - 1.3e-11 44.1 17.5 1.5e-11 43.9 17.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW98683.1 - 6.6e-06 25.3 0.1 7.2e-06 25.1 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter His_Phos_2 PF00328.22 EFW98684.1 - 4.7e-05 22.9 0.0 0.073 12.4 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Zn_clus PF00172.18 EFW98686.1 - 0.00012 22.2 9.2 0.00012 22.2 9.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 EFW98686.1 - 0.021 14.6 0.4 0.056 13.2 0.4 1.7 1 0 0 1 1 1 0 Integrin plexin domain Pex14_N PF04695.13 EFW98686.1 - 0.11 13.2 1.7 0.19 12.4 1.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAP1 PF08601.10 EFW98686.1 - 0.16 11.6 9.9 0.25 11.1 9.9 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 DUF4680 PF15730.5 EFW98686.1 - 1.3 9.3 7.8 3.4 8.0 7.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) Fungal_trans PF04082.18 EFW98687.1 - 4.6e-27 94.7 0.0 2.1e-26 92.5 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFW98687.1 - 7.5e-09 35.6 8.7 1.2e-08 35.0 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2076 PF09849.9 EFW98688.1 - 1e-08 35.6 10.5 1.4e-08 35.1 10.5 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EFW98688.1 - 0.00049 20.2 3.7 0.00069 19.7 3.7 1.2 1 0 0 1 1 1 1 CHCH domain Trypan_glycop_C PF10659.9 EFW98688.1 - 0.024 15.0 1.4 0.033 14.6 1.4 1.1 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain Gly-zipper_YMGG PF13441.6 EFW98688.1 - 0.072 12.8 4.3 0.11 12.2 4.3 1.2 1 0 0 1 1 1 0 YMGG-like Gly-zipper 6PF2K PF01591.18 EFW98690.1 - 2e-67 226.8 0.0 1.5e-47 161.8 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFW98690.1 - 1.2e-28 100.1 0.1 5.5e-23 81.7 0.0 2.8 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFW98690.1 - 0.0019 18.3 0.1 0.14 12.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 EFW98690.1 - 0.019 14.4 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 CARD PF00619.21 EFW98690.1 - 0.024 14.7 0.4 0.087 12.9 0.4 1.9 1 1 0 1 1 1 0 Caspase recruitment domain Cpn60_TCP1 PF00118.24 EFW98693.1 - 1.6e-83 281.0 10.3 4.1e-83 279.7 10.3 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PEMT PF04191.13 EFW98694.1 - 2.4e-58 195.1 7.2 1.3e-36 125.2 0.9 2.5 2 0 0 2 2 2 2 Phospholipid methyltransferase SHE3 PF17078.5 EFW98694.1 - 0.0067 16.2 0.5 0.011 15.4 0.5 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 DUF641 PF04859.12 EFW98694.1 - 0.022 15.1 0.5 0.048 14.0 0.5 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) SKICH PF17751.1 EFW98694.1 - 0.082 13.5 0.0 3.6 8.2 0.0 2.4 2 0 0 2 2 2 0 SKICH domain HECW_N PF16562.5 EFW98694.1 - 0.14 12.0 0.0 0.44 10.4 0.0 1.8 2 0 0 2 2 2 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 TMF_TATA_bd PF12325.8 EFW98694.1 - 0.2 11.9 3.0 0.5 10.6 3.0 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 EFW98694.1 - 0.3 11.2 1.6 0.67 10.0 0.5 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 EFW98694.1 - 0.46 10.6 2.5 1.4 9.1 2.5 1.8 1 0 0 1 1 1 0 bZIP transcription factor APG6_N PF17675.1 EFW98694.1 - 9 6.8 8.6 0.35 11.4 2.3 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region PUF PF00806.19 EFW98695.1 - 7.3e-56 182.8 10.3 3.5e-07 29.5 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Trypan_PARP PF05887.11 EFW98698.1 - 2.2 8.2 7.4 3.7 7.5 7.4 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pyr_redox_2 PF07992.14 EFW98699.1 - 4.9e-37 127.7 0.1 6.3e-37 127.4 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFW98699.1 - 2.7e-11 43.9 0.1 4.5e-09 36.7 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFW98699.1 - 5.5e-05 22.6 0.1 0.00028 20.2 0.1 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFW98699.1 - 0.00037 19.8 0.0 0.0047 16.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) TIP49 PF06068.13 EFW98700.1 - 1.8e-153 510.9 2.0 1.8e-153 510.9 2.0 1.3 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 EFW98700.1 - 5.5e-23 80.9 0.4 2.1e-22 79.0 0.2 2.1 2 0 0 2 2 1 1 TIP49 AAA-lid domain AAA PF00004.29 EFW98700.1 - 4.8e-09 36.7 0.5 1.1e-05 25.8 0.1 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFW98700.1 - 1.9e-08 34.2 0.6 1.2e-05 25.2 0.1 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 EFW98700.1 - 9e-07 28.5 1.3 1.9e-06 27.4 1.3 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EFW98700.1 - 2.9e-06 27.8 0.2 8e-06 26.3 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EFW98700.1 - 0.0027 17.1 1.0 0.024 14.0 0.4 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EFW98700.1 - 0.0034 17.1 0.1 1.1 9.0 0.1 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EFW98700.1 - 0.0066 16.7 0.0 0.77 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFW98700.1 - 0.0072 16.6 0.1 0.024 14.9 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFW98700.1 - 0.015 15.7 3.2 0.57 10.5 3.2 2.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFW98700.1 - 0.019 14.5 0.1 0.044 13.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFW98700.1 - 0.059 13.2 1.2 0.36 10.6 1.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFW98700.1 - 0.11 12.0 0.2 0.46 10.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EFW98700.1 - 0.15 12.1 0.6 0.43 10.6 0.1 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Chorismate_bind PF00425.18 EFW98701.1 - 1.3e-88 296.9 0.0 2.5e-88 296.0 0.0 1.5 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EFW98701.1 - 2.3e-34 118.8 0.0 4.1e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 EFW98701.1 - 2.5e-32 110.8 0.0 6.7e-32 109.4 0.0 1.7 1 0 0 1 1 1 1 GMP synthase C terminal domain Anth_synt_I_N PF04715.13 EFW98701.1 - 2.9e-25 89.1 0.0 5.4e-22 78.5 0.0 3.4 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region NAD_synthase PF02540.17 EFW98701.1 - 6.4e-10 38.6 0.1 2.3e-06 26.9 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EFW98701.1 - 1.2e-05 25.2 0.0 3.2e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EFW98701.1 - 0.0084 15.6 0.0 0.029 13.9 0.0 1.8 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EFW98701.1 - 0.031 13.1 0.1 0.056 12.2 0.1 1.4 1 0 0 1 1 1 0 tRNA methyl transferase ATP_bind_3 PF01171.20 EFW98701.1 - 0.12 12.2 0.0 0.59 9.9 0.1 2.0 2 0 0 2 2 2 0 PP-loop family Asn_synthase PF00733.21 EFW98701.1 - 0.2 11.3 0.0 0.37 10.4 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase D123 PF07065.14 EFW98702.1 - 1.2e-108 362.9 0.0 1.3e-108 362.7 0.0 1.0 1 0 0 1 1 1 1 D123 COesterase PF00135.28 EFW98703.1 - 4.9e-63 213.7 0.0 1.4e-62 212.3 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFW98703.1 - 0.15 11.9 3.2 5 6.9 0.0 3.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF3716 PF12511.8 EFW98704.1 - 1.6e-15 56.9 9.9 2.4e-15 56.3 9.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) gag-asp_proteas PF13975.6 EFW98704.1 - 0.035 14.7 0.4 0.22 12.1 0.0 2.5 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EFW98704.1 - 0.087 13.5 0.2 0.71 10.5 0.0 2.6 2 1 1 3 3 3 0 Aspartyl protease PG_binding_1 PF01471.18 EFW98705.1 - 0.0014 18.8 0.1 0.88 9.8 0.0 3.2 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Tropomyosin_1 PF12718.7 EFW98705.1 - 0.018 15.2 1.6 0.044 13.9 1.6 1.6 1 0 0 1 1 1 0 Tropomyosin like Spc7 PF08317.11 EFW98705.1 - 0.053 12.4 3.0 0.085 11.7 3.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein PG_binding_3 PF09374.10 EFW98705.1 - 0.053 13.8 0.6 3.8 7.9 0.1 3.1 2 1 0 2 2 2 0 Predicted Peptidoglycan domain DUF2937 PF11157.8 EFW98705.1 - 0.18 11.5 0.7 0.36 10.5 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Nup54 PF13874.6 EFW98705.1 - 0.27 11.4 3.8 0.56 10.3 3.8 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 ERM PF00769.19 EFW98705.1 - 1.6 8.5 8.6 3.3 7.4 8.6 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family MbeD_MobD PF04899.12 EFW98705.1 - 4.1 7.6 6.3 33 4.7 6.3 2.2 1 1 0 1 1 1 0 MbeD/MobD like APG6_N PF17675.1 EFW98705.1 - 9.7 6.7 7.5 26 5.3 7.5 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region FAD-oxidase_C PF02913.19 EFW98707.1 - 8.2e-41 140.3 0.6 2.1e-40 139.0 0.6 1.8 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFW98707.1 - 4.2e-37 127.0 0.1 1e-36 125.7 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain Na_Ca_ex PF01699.24 EFW98707.1 - 3e-24 85.7 37.5 2.4e-19 69.8 20.5 3.0 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Spt20 PF12090.8 EFW98707.1 - 1.1 8.8 6.5 3 7.4 6.5 1.7 1 0 0 1 1 1 0 Spt20 family SPT6_acidic PF14632.6 EFW98707.1 - 1.6 9.3 6.7 1.6 9.4 3.8 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 PSP1 PF04468.12 EFW98708.1 - 1.2e-27 95.9 1.7 2.8e-27 94.8 1.7 1.6 1 0 0 1 1 1 1 PSP1 C-terminal conserved region CAP_GLY PF01302.25 EFW98709.1 - 3.6e-21 74.9 1.1 5.4e-21 74.4 1.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EFW98709.1 - 7.5e-17 61.6 0.0 1.2e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain HET PF06985.11 EFW98710.1 - 7.9e-32 110.6 0.5 1.6e-31 109.7 0.2 1.7 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Utp11 PF03998.13 EFW98711.1 - 1.2e-55 189.1 30.1 1.4e-55 188.9 30.1 1.0 1 0 0 1 1 1 1 Utp11 protein CENP-B_dimeris PF09026.10 EFW98711.1 - 0.18 12.2 8.1 0.29 11.6 2.4 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RRN3 PF05327.11 EFW98711.1 - 9.3 4.6 7.9 14 4.0 7.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AKAP7_NLS PF10469.9 EFW98712.1 - 8e-20 71.6 0.0 1.2e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain NFACT-R_1 PF05670.13 EFW98713.1 - 4.2e-41 140.0 0.1 6.4e-41 139.4 0.1 1.3 1 0 0 1 1 1 1 NFACT protein RNA binding domain Ribosomal_L3 PF00297.22 EFW98714.1 - 1.2e-170 567.4 10.7 1.5e-170 567.1 10.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 LIP PF03583.14 EFW98715.1 - 1.2e-59 202.0 0.4 1.7e-59 201.5 0.4 1.1 1 0 0 1 1 1 1 Secretory lipase RIO1 PF01163.22 EFW98716.1 - 3.8e-41 140.8 0.1 2.5e-29 102.3 0.0 2.1 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 EFW98716.1 - 1.3e-30 105.5 0.0 2.3e-30 104.6 0.0 1.5 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EFW98716.1 - 3.2e-06 27.3 0.2 0.03 14.2 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EFW98716.1 - 7.9e-06 25.4 0.2 0.00013 21.4 0.2 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4920 PF16267.5 EFW98716.1 - 0.083 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4920) Fungal_trans PF04082.18 EFW98717.1 - 6.6e-17 61.4 2.7 1.1e-16 60.7 2.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EFW98717.1 - 4.2e-08 33.3 12.1 1.1e-05 25.6 5.8 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFW98717.1 - 0.00079 19.8 14.6 0.039 14.4 5.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF3541 PF12060.8 EFW98717.1 - 0.037 13.7 0.8 0.084 12.6 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3541) zf-C2H2_3rep PF18868.1 EFW98717.1 - 0.089 13.5 1.1 2.2 9.0 0.4 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EFW98717.1 - 0.23 12.4 19.5 0.27 12.2 4.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFW98717.1 - 0.46 10.8 3.7 1.4 9.3 3.7 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 EFW98717.1 - 1.6 8.9 4.1 4.1 7.6 4.1 1.7 1 0 0 1 1 1 0 Zinc ribbon domain PMT PF02366.18 EFW98718.1 - 4e-81 272.2 15.4 4e-81 272.2 15.4 1.9 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EFW98718.1 - 6.7e-66 221.7 14.4 1.9e-65 220.2 14.4 1.8 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EFW98718.1 - 6.1e-34 117.5 0.3 9.3e-34 116.9 0.3 1.1 1 0 0 1 1 1 1 MIR domain DUF2976 PF11190.8 EFW98718.1 - 0.053 13.3 3.4 0.42 10.4 2.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Syndecan PF01034.20 EFW98718.1 - 8.4 6.4 6.4 0.83 9.6 0.9 2.3 2 0 0 2 2 2 0 Syndecan domain WD40 PF00400.32 EFW98719.1 - 2.3e-16 59.9 2.4 3.3e-07 30.9 0.2 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW98719.1 - 9.6e-06 25.8 0.0 6.2 7.2 0.0 4.3 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SUKH_6 PF14568.6 EFW98719.1 - 0.058 13.8 0.0 0.42 11.0 0.0 2.4 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall GRAB PF10375.9 EFW98720.1 - 0.0063 16.3 1.2 0.0063 16.3 1.2 2.9 3 0 0 3 3 3 1 GRIP-related Arf-binding domain TPR_MLP1_2 PF07926.12 EFW98720.1 - 0.013 15.5 14.8 0.013 15.5 14.8 4.2 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 EFW98720.1 - 0.052 11.1 50.6 0.074 10.6 50.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ETRAMP PF09716.10 EFW98720.1 - 0.34 11.0 4.8 4.6 7.4 0.2 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Lectin_N PF03954.14 EFW98720.1 - 2.4 7.9 11.9 6 6.6 0.1 3.4 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Snapin_Pallidin PF14712.6 EFW98720.1 - 4.2 7.8 27.5 0.48 10.9 5.8 3.9 3 2 0 3 3 3 0 Snapin/Pallidin VPS11_C PF12451.8 EFW98720.1 - 6 7.2 11.6 0.89 9.8 1.7 3.9 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal Prominin PF05478.11 EFW98720.1 - 6.1 4.7 10.8 3.2 5.6 2.1 2.2 2 0 0 2 2 2 0 Prominin Golgin_A5 PF09787.9 EFW98720.1 - 6.8 6.1 54.2 0.32 10.4 19.7 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 Apolipoprotein PF01442.18 EFW98720.1 - 7.8 6.3 65.9 5.9 6.7 34.0 2.3 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Pec_lyase_C PF00544.19 EFW98721.1 - 3.5e-13 49.6 9.6 1.2e-11 44.6 9.6 2.3 1 1 0 1 1 1 1 Pectate lyase MR_MLE_N PF02746.16 EFW98721.1 - 0.046 13.9 0.9 1.1 9.5 0.2 2.5 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Beta_helix PF13229.6 EFW98721.1 - 0.063 13.1 25.3 0.037 13.9 14.4 2.5 1 1 1 2 2 2 0 Right handed beta helix region His_Phos_1 PF00300.22 EFW98722.1 - 3.1e-26 92.3 0.0 3.1e-26 92.3 0.0 2.1 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 EFW98722.1 - 0.022 14.1 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) PHD PF00628.29 EFW98723.1 - 1.5e-11 44.0 6.9 3.4e-11 42.9 6.9 1.6 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EFW98723.1 - 0.77 9.9 5.4 1.8 8.7 5.4 1.6 1 0 0 1 1 1 0 PHD-finger Proteasome PF00227.26 EFW98724.1 - 5.4e-55 185.8 0.1 8.4e-55 185.2 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFW98724.1 - 1.1e-11 44.1 0.4 3.6e-11 42.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Terminase_5 PF06056.12 EFW98724.1 - 0.02 14.8 0.1 0.042 13.7 0.1 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) IL6 PF00489.17 EFW98724.1 - 0.16 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Methyltr_RsmB-F PF01189.17 EFW98725.1 - 8.9e-79 263.8 0.0 1.4e-78 263.1 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EFW98725.1 - 9.1e-09 35.7 0.0 2.2e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 EFW98725.1 - 0.052 14.3 0.0 0.14 12.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain zf-HIT PF04438.16 EFW98726.1 - 1.5e-10 40.8 11.5 2.2e-10 40.2 11.5 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 EFW98726.1 - 2e-05 24.6 10.2 3.5e-05 23.8 10.2 1.4 1 0 0 1 1 1 1 MYND finger API5 PF05918.11 EFW98726.1 - 0.57 8.9 1.6 0.49 9.1 0.4 1.5 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) zf-B_box PF00643.24 EFW98726.1 - 1.1 9.4 7.3 1.8 8.8 7.3 1.3 1 0 0 1 1 1 0 B-box zinc finger adh_short PF00106.25 EFW98727.1 - 1.6e-25 89.7 0.0 2.3e-24 85.9 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW98727.1 - 8.7e-14 51.6 0.0 2.2e-13 50.3 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW98727.1 - 7.2e-08 32.5 0.1 1.1e-07 31.9 0.1 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFW98727.1 - 0.0046 16.1 0.0 0.0058 15.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RSN1_7TM PF02714.15 EFW98728.1 - 2.1e-83 279.8 23.9 2.1e-83 279.8 23.9 1.9 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFW98728.1 - 2.5e-39 134.5 2.2 2.5e-39 134.5 2.2 3.3 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFW98728.1 - 5.3e-31 108.2 1.6 8.3e-17 62.0 0.3 2.4 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EFW98728.1 - 1.5e-15 57.1 0.0 4e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter Cytochrom_B561 PF03188.16 EFW98729.1 - 5.2e-14 52.6 3.4 5.2e-14 52.6 3.4 1.7 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 MASE5 PF17178.4 EFW98729.1 - 1.2 8.9 11.2 19 5.0 11.2 2.3 1 1 0 1 1 1 0 Membrane-associated sensor DUF2427 PF10348.9 EFW98729.1 - 1.3 8.9 10.3 0.5 10.2 2.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) SLATT_3 PF18184.1 EFW98729.1 - 6.1 7.0 7.8 1.4 9.0 0.2 2.4 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 3 Pkinase PF00069.25 EFW98730.1 - 2e-61 207.7 0.0 2.4e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW98730.1 - 4.5e-35 121.2 0.0 7.4e-35 120.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFW98730.1 - 8.7e-06 25.2 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFW98730.1 - 0.0013 17.6 0.0 0.0018 17.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFW98730.1 - 0.18 11.4 0.0 4 7.0 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SSI PF00720.17 EFW98731.1 - 0.0095 15.9 0.1 0.011 15.6 0.1 1.1 1 0 0 1 1 1 1 Subtilisin inhibitor-like CRM1_C PF08767.11 EFW98732.1 - 6.7e-131 436.2 1.1 6.7e-131 436.2 1.1 3.2 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EFW98732.1 - 1.8e-40 138.4 7.2 1.8e-40 138.4 7.2 3.5 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EFW98732.1 - 1.2e-33 114.5 4.1 4.5e-33 112.7 4.1 2.1 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EFW98732.1 - 2.2e-28 98.1 1.8 1e-27 96.0 1.2 2.6 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EFW98732.1 - 1.6e-19 69.1 1.7 3.6e-19 68.0 1.7 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EFW98732.1 - 4.8e-14 52.0 0.1 2.2e-13 49.9 0.1 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3385 PF11865.8 EFW98732.1 - 0.0045 16.9 1.2 1 9.2 0.0 4.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) Mem_trans PF03547.18 EFW98732.1 - 0.067 11.6 0.0 0.12 10.8 0.0 1.3 1 0 0 1 1 1 0 Membrane transport protein RNase_T PF00929.24 EFW98733.1 - 1.7e-20 74.3 0.0 8.2e-20 72.0 0.0 1.8 1 1 0 1 1 1 1 Exonuclease DnaG_DnaB_bind PF08278.11 EFW98733.1 - 0.0076 16.8 0.1 0.011 16.3 0.1 1.2 1 0 0 1 1 1 1 DNA primase DnaG DnaB-binding ILVD_EDD PF00920.21 EFW98733.1 - 0.1 11.2 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Dehydratase family HET PF06985.11 EFW98735.1 - 2.4e-34 118.8 1.0 4.5e-34 117.9 1.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ZZ PF00569.17 EFW98735.1 - 2.4e-08 33.6 7.0 4.3e-08 32.8 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Tnp_zf-ribbon_2 PF13842.6 EFW98735.1 - 7.7 7.4 7.7 26 5.7 7.2 2.3 1 1 1 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Proteasome PF00227.26 EFW98737.1 - 5.4e-56 189.1 0.0 2.9e-32 111.7 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EFW98737.1 - 1.3e-10 40.7 0.3 3.3e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RhoGAP PF00620.27 EFW98738.1 - 2.9e-46 157.1 1.3 4.5e-46 156.4 0.0 2.0 3 0 0 3 3 3 1 RhoGAP domain LIM PF00412.22 EFW98738.1 - 8.1e-14 51.6 18.1 2.4e-09 37.3 2.4 2.4 2 0 0 2 2 2 2 LIM domain Herpes_BLRF2 PF05812.12 EFW98738.1 - 0.043 13.9 2.9 0.16 12.1 2.9 2.0 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Desulfoferrod_N PF06397.12 EFW98738.1 - 2.2 8.0 10.3 14 5.4 0.9 3.5 2 1 1 3 3 3 0 Desulfoferrodoxin, N-terminal domain Zn-ribbon_8 PF09723.10 EFW98738.1 - 4.4 7.5 18.7 1.1 9.4 1.2 4.1 3 1 1 4 4 4 0 Zinc ribbon domain KASH_CCD PF14662.6 EFW98738.1 - 9.7 6.0 20.6 62 3.3 20.2 2.2 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DcpS_C PF11969.8 EFW98739.1 - 7.8e-11 42.5 0.9 2.9e-10 40.6 0.9 1.8 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EFW98739.1 - 0.0025 18.5 4.1 0.035 14.8 4.1 2.3 1 1 0 1 1 1 1 HIT domain DUF4931 PF16285.5 EFW98739.1 - 0.1 11.8 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4931) DUF2024 PF09630.10 EFW98739.1 - 0.15 11.9 0.5 0.33 10.9 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) Zn_clus PF00172.18 EFW98740.1 - 9.9e-08 32.0 8.3 1.6e-07 31.3 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFW98740.1 - 0.003 16.4 0.6 0.0061 15.4 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain US10 PF17617.2 EFW98740.1 - 0.032 14.3 0.2 0.058 13.5 0.2 1.4 1 0 0 1 1 1 0 Viral unique short region 10 Ferric_reduct PF01794.19 EFW98741.1 - 3.7e-18 65.9 7.0 9.8e-18 64.5 7.0 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFW98741.1 - 1.4e-13 51.2 0.0 3e-09 37.2 0.0 2.9 3 0 0 3 3 3 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFW98741.1 - 3.9e-12 46.2 0.0 1e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EFW98741.1 - 0.0025 18.4 0.0 0.15 12.7 0.0 2.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Baculo_gp64 PF03273.13 EFW98741.1 - 0.27 10.0 0.0 0.39 9.5 0.0 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family DUF4405 PF14358.6 EFW98741.1 - 6.3 7.4 10.6 0.36 11.4 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) TPR_12 PF13424.6 EFW98742.1 - 1.5e-16 60.5 13.8 5.7e-07 29.7 0.2 4.0 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFW98742.1 - 9.9e-14 50.7 11.9 0.00028 20.7 1.9 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat AAA_16 PF13191.6 EFW98742.1 - 4.8e-07 30.3 3.6 8.7e-07 29.5 0.2 2.8 2 1 1 3 3 3 1 AAA ATPase domain ATPase_2 PF01637.18 EFW98742.1 - 0.0048 16.9 0.0 0.0091 15.9 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFW98742.1 - 0.006 16.3 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 EFW98742.1 - 0.033 14.1 0.0 1.3 8.9 0.0 3.0 4 0 0 4 4 4 0 NACHT domain MFS_1 PF07690.16 EFW98743.1 - 1.5e-30 106.4 80.2 4.5e-24 85.0 39.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NADH_oxidored PF08040.11 EFW98743.1 - 0.14 11.8 0.2 3.9 7.2 0.0 2.9 2 0 0 2 2 2 0 MNLL subunit ITAM_Cys-rich PF10538.9 EFW98743.1 - 4.7 7.1 6.7 5.1 6.9 0.5 2.4 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif KH_1 PF00013.29 EFW98744.1 - 1.2e-46 156.4 13.1 1.7e-16 59.8 1.5 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EFW98744.1 - 7e-11 41.8 6.7 0.0053 16.5 0.6 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EFW98744.1 - 1.7e-08 34.2 5.4 0.046 13.6 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EFW98744.1 - 0.026 14.6 3.1 21 5.3 0.1 3.5 3 0 0 3 3 3 0 NusA-like KH domain MOEP19 PF16005.5 EFW98744.1 - 0.034 14.1 0.1 5.3 7.1 0.0 3.0 3 0 0 3 3 3 0 KH-like RNA-binding domain Nic96 PF04097.14 EFW98745.1 - 5.9e-216 718.7 0.0 7.8e-216 718.3 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Med15 PF09606.10 EFW98745.1 - 0.63 8.7 7.1 1.6 7.4 7.1 1.6 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Diphthamide_syn PF01866.17 EFW98746.1 - 2.6e-109 365.4 0.0 3.2e-109 365.0 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein WD40 PF00400.32 EFW98747.1 - 2.5e-12 47.1 0.4 0.011 16.6 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW98747.1 - 1.4e-09 38.1 0.0 0.0039 17.5 0.0 4.8 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EFW98747.1 - 4e-06 26.6 0.0 7.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 EFW98747.1 - 0.016 15.1 0.1 6.7 6.5 0.0 3.6 5 1 0 5 5 5 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFW98747.1 - 0.12 11.3 0.1 0.8 8.6 0.1 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TruB_C PF09142.11 EFW98747.1 - 4.4 7.2 5.3 13 5.7 0.0 3.2 3 1 1 4 4 4 0 tRNA Pseudouridine synthase II, C terminal Transferase PF02458.15 EFW98749.1 - 2.9e-23 82.2 0.0 3.4e-14 52.4 0.0 3.4 2 1 0 2 2 2 2 Transferase family Sugar_tr PF00083.24 EFW98750.1 - 4e-44 151.2 19.5 5e-44 150.9 19.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFW98750.1 - 6.6e-17 61.5 24.0 1.1e-16 60.7 24.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily PUF PF00806.19 EFW98751.1 - 6.8e-28 94.8 4.3 8.5e-06 25.2 0.0 7.6 8 0 0 8 8 8 6 Pumilio-family RNA binding repeat MRP-S33 PF08293.11 EFW98751.1 - 1.3e-25 89.4 0.0 3e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Wtap PF17098.5 EFW98751.1 - 0.0092 15.9 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 1 WTAP/Mum2p family tRNA-synt_2d PF01409.20 EFW98752.1 - 3.1e-49 167.7 0.0 5e-25 88.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EFW98752.1 - 1.6e-24 86.2 0.0 3.2e-24 85.2 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF3811 PF11656.8 EFW98752.1 - 0.15 12.5 0.1 0.27 11.6 0.1 1.3 1 0 0 1 1 1 0 YjbD family (DUF3811) Aminotran_4 PF01063.19 EFW98753.1 - 2.4e-11 43.9 0.2 0.00018 21.4 0.0 2.1 1 1 1 2 2 2 2 Amino-transferase class IV DMRL_synthase PF00885.19 EFW98755.1 - 2.8e-55 186.0 0.0 3.4e-55 185.7 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Rick_17kDa_Anti PF05433.15 EFW98756.1 - 9.3e-06 25.4 4.8 0.0037 17.1 0.0 2.4 2 0 0 2 2 2 2 Glycine zipper 2TM domain DUF4235 PF14019.6 EFW98756.1 - 0.059 13.4 0.5 0.096 12.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) Gly-zipper_Omp PF13488.6 EFW98756.1 - 0.34 10.9 16.3 7.8 6.6 16.2 2.3 1 1 1 2 2 2 0 Glycine zipper DUF2530 PF10745.9 EFW98756.1 - 0.42 10.9 10.3 0.45 10.8 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2530) Gly-zipper_YMGG PF13441.6 EFW98756.1 - 1.2 8.9 11.8 5.4 6.8 11.8 2.0 1 1 0 1 1 1 0 YMGG-like Gly-zipper CLASP_N PF12348.8 EFW98758.1 - 0.00093 18.8 0.0 0.27 10.7 0.0 3.9 3 0 0 3 3 3 1 CLASP N terminal Vac14_Fab1_bd PF12755.7 EFW98758.1 - 0.0027 18.3 0.0 0.6 10.7 0.0 4.4 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFW98758.1 - 0.0098 16.4 27.0 0.67 10.5 0.0 9.5 9 1 0 9 9 9 2 HEAT-like repeat HEAT PF02985.22 EFW98758.1 - 0.019 15.2 23.6 0.33 11.3 0.0 9.6 10 0 0 10 10 10 0 HEAT repeat UNC45-central PF11701.8 EFW98758.1 - 0.075 13.0 0.1 0.72 9.8 0.0 2.8 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central Skp1 PF01466.19 EFW98759.1 - 2.4e-29 101.2 0.5 2.4e-29 101.2 0.5 1.8 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EFW98759.1 - 1.5e-19 69.9 0.0 4e-19 68.6 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Trnau1ap PF17654.1 EFW98759.1 - 0.03 15.2 0.1 0.041 14.7 0.1 1.3 1 0 0 1 1 1 0 Selenocysteine tRNA 1 associated proteins DAO PF01266.24 EFW98760.1 - 9.9e-34 117.4 0.2 1.5e-33 116.8 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFW98760.1 - 0.0004 20.9 0.0 0.5 10.9 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFW98760.1 - 0.0009 19.4 0.1 0.0032 17.7 0.1 2.0 1 1 1 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW98760.1 - 0.0037 16.5 0.2 1.4 8.1 0.2 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFW98760.1 - 0.0046 15.9 0.1 1.1 8.0 0.1 2.3 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 EFW98760.1 - 0.054 12.7 0.1 0.082 12.1 0.1 1.2 1 0 0 1 1 1 0 Thi4 family Mqo PF06039.15 EFW98760.1 - 0.1 11.1 0.1 0.16 10.4 0.1 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Pkinase PF00069.25 EFW98761.1 - 2.8e-19 69.5 0.0 1.3e-08 34.6 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain FHA PF00498.26 EFW98761.1 - 3.2e-09 37.0 0.9 1.7e-08 34.7 0.1 2.2 2 0 0 2 2 2 1 FHA domain Pkinase_Tyr PF07714.17 EFW98761.1 - 1.1e-05 24.9 0.0 0.058 12.7 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase SNARE PF05739.19 EFW98762.1 - 2.9e-07 30.4 1.3 5e-07 29.6 1.3 1.4 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.9 EFW98762.1 - 0.047 13.4 0.3 0.29 10.8 0.1 2.1 2 0 0 2 2 2 0 Membrane fusion protein Use1 Lyase_8_N PF08124.11 EFW98762.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain RRM_1 PF00076.22 EFW98763.1 - 1.5e-14 53.5 0.5 6.1e-14 51.6 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFW98763.1 - 0.0016 18.0 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC2_membrane PF01061.24 EFW98765.1 - 2.4e-40 138.2 23.8 4.3e-36 124.3 12.6 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EFW98765.1 - 1.1e-32 113.4 0.0 2.5e-22 79.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFW98765.1 - 6.4e-29 99.7 1.8 1.6e-25 88.8 0.3 2.6 2 0 0 2 2 2 2 CDR ABC transporter SMC_N PF02463.19 EFW98765.1 - 3.5e-07 29.9 0.0 0.057 12.8 0.0 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFW98765.1 - 6.1e-05 23.0 0.0 0.045 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFW98765.1 - 0.00053 19.9 0.1 0.0011 18.8 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFW98765.1 - 0.002 18.5 0.0 0.0051 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFW98765.1 - 0.017 14.9 0.1 0.047 13.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EFW98765.1 - 0.036 14.2 0.0 0.08 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFW98765.1 - 0.061 12.9 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFW98765.1 - 0.091 12.7 0.1 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 EFW98765.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFW98765.1 - 0.14 12.1 0.1 0.4 10.7 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EFW98765.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFW98765.1 - 0.18 11.5 0.1 0.36 10.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFW98765.1 - 0.18 11.5 0.0 4.5 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Leader_CPA1 PF08252.11 EFW98765.1 - 0.26 10.7 1.5 6.1 6.3 0.1 2.5 2 0 0 2 2 2 0 arg-2/CPA1 leader peptide Tom37 PF10568.9 EFW98766.1 - 1.6e-34 118.9 0.0 9.4e-34 116.4 0.0 2.1 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EFW98766.1 - 4.1e-06 26.5 0.2 1.3e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFW98766.1 - 0.0084 16.8 0.0 0.023 15.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain F-box PF00646.33 EFW98767.1 - 0.00021 21.1 1.0 0.00021 21.1 1.0 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFW98767.1 - 0.024 14.5 0.1 0.088 12.7 0.1 2.0 1 0 0 1 1 1 0 F-box-like p450 PF00067.22 EFW98768.1 - 9.9e-45 153.1 0.0 1.3e-44 152.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RNA_pol_Rpb5_C PF01191.19 EFW98768.1 - 0.17 11.8 0.0 0.43 10.5 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain FMN_dh PF01070.18 EFW98769.1 - 5.8e-93 311.7 0.2 9.5e-93 311.0 0.2 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EFW98769.1 - 3.5e-16 59.1 0.0 7.3e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EFW98769.1 - 8.3e-06 25.2 0.1 1.5e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EFW98769.1 - 0.0012 18.2 0.8 0.07 12.4 0.1 2.3 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EFW98769.1 - 0.0013 17.8 0.8 0.0075 15.3 0.1 2.2 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain DGF-1_5 PF11038.8 EFW98769.1 - 0.0021 17.5 0.0 0.0044 16.4 0.0 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 Hamartin PF04388.12 EFW98770.1 - 9.1e-21 74.2 0.1 9.1e-21 74.2 0.1 3.7 2 1 1 4 4 4 1 Hamartin protein GAS PF13851.6 EFW98770.1 - 0.055 12.8 43.0 0.32 10.3 21.8 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF737 PF05300.11 EFW98770.1 - 2 8.8 41.5 35 4.7 0.1 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF737) PIG-U PF06728.13 EFW98771.1 - 2e-125 418.8 26.6 2.3e-125 418.6 26.6 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mannosyl_trans PF05007.13 EFW98771.1 - 1.2e-05 25.3 0.8 1.2e-05 25.3 0.8 1.7 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) 8TM_micro PF17028.5 EFW98771.1 - 0.27 10.9 7.3 1.3 8.7 7.3 2.0 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain BatA PF07584.11 EFW98771.1 - 6.5 7.2 16.3 0.21 12.0 1.0 3.8 3 1 1 4 4 4 0 Aerotolerance regulator N-terminal AAA_12 PF13087.6 EFW98772.1 - 3e-07 30.3 0.0 3.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EFW98772.1 - 0.026 14.3 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2415 PF10313.9 EFW98773.1 - 1.3e-10 41.0 0.0 4e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.32 EFW98773.1 - 0.0019 19.0 0.3 6.5 7.8 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW98773.1 - 0.016 15.5 0.0 3.2 8.1 0.0 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain ECH_1 PF00378.20 EFW98774.1 - 1.7e-72 243.7 0.0 2e-72 243.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFW98774.1 - 6e-34 118.0 0.7 4.6e-31 108.6 0.2 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase PilI PF10623.9 EFW98774.1 - 0.051 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Plasmid conjugative transfer protein PilI DUF4097 PF13349.6 EFW98775.1 - 5.6e-05 22.6 0.1 0.00011 21.7 0.1 1.6 1 0 0 1 1 1 1 Putative adhesin DUF4993 PF16384.5 EFW98775.1 - 0.044 12.8 0.0 0.087 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function Blt1 PF12754.7 EFW98776.1 - 9e-36 123.5 0.0 1.5e-35 122.7 0.0 1.4 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 EFW98776.1 - 2.6e-13 49.4 0.2 4.4e-13 48.6 0.2 1.4 1 0 0 1 1 1 1 Get5 carboxyl domain ubiquitin PF00240.23 EFW98776.1 - 0.016 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family ATP-synt_ab PF00006.25 EFW98777.1 - 1.5e-60 204.5 0.0 2.4e-60 203.8 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFW98777.1 - 7.7e-23 80.8 0.4 2.2e-22 79.4 0.2 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Alpha-amylase_C PF02806.18 EFW98777.1 - 8.8e-21 74.2 0.0 2.7e-20 72.6 0.0 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EFW98777.1 - 4.4e-18 65.4 0.0 8.6e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EFW98777.1 - 2.7e-14 53.5 0.1 7.9e-11 42.1 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain RsgA_GTPase PF03193.16 EFW98777.1 - 0.034 14.1 0.5 0.079 12.9 0.1 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 EFW98777.1 - 0.078 13.4 0.1 3.2 8.2 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFW98777.1 - 0.094 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EFW98777.1 - 0.097 11.8 0.4 0.26 10.4 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 EFW98777.1 - 0.13 12.2 0.0 0.37 10.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 EFW98777.1 - 0.18 11.1 0.3 0.33 10.2 0.3 1.4 1 0 0 1 1 1 0 KaiC RNA_helicase PF00910.22 EFW98777.1 - 0.2 12.1 0.0 0.48 10.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase T3SS_ATPase_C PF18269.1 EFW98777.1 - 0.2 11.5 0.5 0.76 9.7 0.5 2.0 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 EFW98777.1 - 0.24 11.8 0.9 1.4 9.3 0.2 2.4 2 0 0 2 2 2 0 AAA domain DUF2012 PF09430.10 EFW98779.1 - 8.8e-09 35.5 0.0 1.5e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) SOP4 PF17081.5 EFW98779.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Suppressor of PMA 1-7 protein Serglycin PF04360.12 EFW98779.1 - 0.94 9.4 2.8 1.6 8.7 2.8 1.4 1 0 0 1 1 1 0 Serglycin HET PF06985.11 EFW98780.1 - 2.2e-26 93.0 1.4 4e-26 92.1 1.4 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) CMS1 PF14617.6 EFW98781.1 - 1.2e-74 250.9 0.2 1.4e-74 250.6 0.2 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EFW98781.1 - 2e-05 24.5 0.0 3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_60s PF00428.19 EFW98781.1 - 0.18 12.4 1.1 0.37 11.4 1.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein PAS_3 PF08447.12 EFW98782.1 - 6.5e-13 48.8 0.0 6.9e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFW98782.1 - 1.2e-10 41.6 0.0 4e-07 30.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 EFW98782.1 - 1.3e-09 38.0 0.0 0.00018 21.5 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EFW98782.1 - 3.8e-06 27.0 0.0 0.0002 21.5 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EFW98782.1 - 4.9e-05 23.5 0.0 0.0095 16.2 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_12 PF18095.1 EFW98782.1 - 0.12 12.1 0.0 5.1 6.7 0.0 2.2 2 0 0 2 2 2 0 UPF0242 C-terminal PAS-like domain Paf1 PF03985.13 EFW98783.1 - 1.4e-82 278.0 0.0 1.6e-82 277.8 0.0 1.0 1 0 0 1 1 1 1 Paf1 Pkinase PF00069.25 EFW98784.1 - 7e-15 55.1 0.0 4.9e-09 35.9 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFW98784.1 - 0.00011 21.6 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Nop14 PF04147.12 EFW98784.1 - 0.44 8.7 4.7 0.59 8.3 4.7 1.1 1 0 0 1 1 1 0 Nop14-like family UCH PF00443.29 EFW98785.1 - 7.8e-34 117.3 0.0 1e-29 103.9 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFW98785.1 - 0.00041 20.0 7.6 0.095 12.3 1.8 3.6 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Bd3614-deam PF14439.6 EFW98786.1 - 0.054 13.6 0.3 0.12 12.5 0.3 1.6 1 0 0 1 1 1 0 Bd3614-like deaminase Na_trans_assoc PF06512.13 EFW98786.1 - 0.32 11.2 1.8 0.5 10.6 1.8 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated DUF4611 PF15387.6 EFW98786.1 - 1.3 9.3 7.2 3.3 8.0 7.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 EFW98786.1 - 5.9 4.9 17.2 0.14 10.3 3.2 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Bystin PF05291.11 EFW98788.1 - 2e-120 401.5 0.0 2.5e-120 401.2 0.0 1.1 1 0 0 1 1 1 1 Bystin Rrn6 PF10214.9 EFW98789.1 - 3.9e-123 412.8 0.0 5.1e-123 412.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor PITH PF06201.13 EFW98789.1 - 2.1e-38 131.9 0.0 3.5e-38 131.2 0.0 1.4 1 0 0 1 1 1 1 PITH domain Rgp1 PF08737.10 EFW98789.1 - 0.021 14.0 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Rgp1 Coa1 PF08695.10 EFW98790.1 - 8.5e-39 131.9 0.0 1.7e-38 130.9 0.0 1.5 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Trypsin_2 PF13365.6 EFW98790.1 - 0.00077 20.4 0.0 0.0026 18.7 0.0 2.0 1 0 0 1 1 1 1 Trypsin-like peptidase domain Aldolase_II PF00596.21 EFW98791.1 - 2.5e-37 128.6 0.6 3.4e-37 128.2 0.6 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ATP-grasp_2 PF08442.10 EFW98793.1 - 2e-76 256.0 3.6 2.8e-76 255.6 1.1 2.0 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EFW98793.1 - 2.7e-24 85.7 0.9 5.1e-24 84.8 0.9 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EFW98793.1 - 5.6e-07 29.2 0.1 1.8e-06 27.6 0.1 1.9 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFW98793.1 - 0.00016 21.5 0.7 0.0073 16.1 0.1 2.6 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain VID27_N PF17748.1 EFW98793.1 - 0.057 13.3 1.2 0.097 12.5 1.2 1.3 1 0 0 1 1 1 0 VID27 N-terminal region PRP38 PF03371.15 EFW98794.1 - 5.3e-55 186.0 0.0 7.1e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Ank_5 PF13857.6 EFW98795.1 - 3.9e-12 46.1 0.2 2.4e-07 30.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFW98795.1 - 1.1e-09 38.8 0.3 2e-05 25.1 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFW98795.1 - 1.2e-07 32.1 0.5 0.017 15.7 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW98795.1 - 1.9e-07 30.8 0.1 0.0012 19.1 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFW98795.1 - 3.6e-07 30.3 2.4 0.00023 21.5 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ribosom_S12_S23 PF00164.25 EFW98796.1 - 3.8e-51 171.5 0.6 4.7e-51 171.2 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ank_2 PF12796.7 EFW98798.1 - 2.8e-21 75.9 1.4 2.1e-09 37.8 0.0 3.4 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) SPX PF03105.19 EFW98798.1 - 9.6e-21 75.1 16.3 7.1e-10 39.3 1.7 3.1 1 1 2 3 3 3 3 SPX domain Ank_4 PF13637.6 EFW98798.1 - 2e-20 72.9 4.6 2.6e-10 40.6 0.0 5.2 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW98798.1 - 2.9e-14 51.8 4.7 0.00019 21.6 0.0 5.5 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EFW98798.1 - 1.3e-12 47.7 5.8 0.00029 21.1 0.0 5.9 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFW98798.1 - 1.6e-11 44.1 2.2 0.002 18.5 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat GDPD PF03009.17 EFW98798.1 - 1.4e-10 41.4 0.0 4.5e-10 39.7 0.0 1.8 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family CitT PF12431.8 EFW98798.1 - 0.036 14.4 1.3 0.13 12.6 0.1 2.5 2 0 0 2 2 2 0 Transcriptional regulator DASH_Dad2 PF08654.10 EFW98799.1 - 6.2e-29 100.3 6.0 2.1e-28 98.6 6.0 1.8 1 1 0 1 1 1 1 DASH complex subunit Dad2 APG6_N PF17675.1 EFW98799.1 - 0.032 14.8 1.4 0.05 14.1 1.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Rogdi_lz PF10259.9 EFW98799.1 - 0.057 12.9 0.7 0.064 12.7 0.7 1.1 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein DASH_Duo1 PF08651.10 EFW98799.1 - 0.068 12.9 1.0 0.16 11.8 1.1 1.6 2 0 0 2 2 2 0 DASH complex subunit Duo1 Matrilin_ccoil PF10393.9 EFW98799.1 - 0.088 12.7 1.6 0.17 11.7 1.6 1.5 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin NPV_P10 PF05531.12 EFW98799.1 - 0.16 12.4 2.3 0.35 11.4 2.3 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Arm PF00514.23 EFW98800.1 - 3e-08 33.4 15.4 0.052 13.6 0.2 8.3 9 0 0 9 9 9 3 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 EFW98800.1 - 0.0019 17.5 0.0 0.22 10.8 0.0 2.6 2 1 0 2 2 2 1 V-ATPase subunit H HEAT_EZ PF13513.6 EFW98800.1 - 0.037 14.5 16.5 2.3 8.8 0.1 7.1 6 1 1 7 7 7 0 HEAT-like repeat HEAT PF02985.22 EFW98800.1 - 0.05 13.9 18.2 2.2 8.7 0.0 8.3 9 0 0 9 9 9 0 HEAT repeat Spt5_N PF11942.8 EFW98800.1 - 0.11 13.5 12.8 0.31 12.0 5.8 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Myc_N PF01056.18 EFW98800.1 - 0.13 12.2 2.0 0.14 12.0 0.5 1.8 2 0 0 2 2 2 0 Myc amino-terminal region BSP_II PF05432.11 EFW98800.1 - 0.72 9.5 5.4 1.8 8.2 2.6 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) YL1 PF05764.13 EFW98800.1 - 1.9 8.5 4.4 12 5.9 1.1 2.2 2 0 0 2 2 2 0 YL1 nuclear protein CENP-B_dimeris PF09026.10 EFW98800.1 - 2.6 8.5 23.8 3.4 8.1 1.4 2.9 2 1 0 2 2 2 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EFW98800.1 - 9.5 6.7 14.7 5.4 7.5 2.1 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SbcCD_C PF13558.6 EFW98801.1 - 2.8e-06 27.5 0.0 1.2e-05 25.4 0.0 2.2 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 EFW98801.1 - 0.00023 21.1 0.0 0.00076 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system GGACT PF06094.12 EFW98801.1 - 0.052 14.1 0.2 0.33 11.6 0.2 2.5 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like KdpC PF02669.15 EFW98801.1 - 0.16 11.8 4.5 0.069 13.0 0.4 2.5 2 0 0 2 2 2 0 K+-transporting ATPase, c chain SMC_N PF02463.19 EFW98801.1 - 8.6 5.7 26.3 16 4.8 26.3 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_2 PF07724.14 EFW98802.1 - 1.6e-32 113.0 0.0 4.5e-32 111.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFW98802.1 - 8.9e-13 48.8 0.0 1.6e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFW98802.1 - 1.1e-08 34.9 0.0 2.4e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFW98802.1 - 2.2e-06 27.7 0.0 5.2e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFW98802.1 - 0.0003 21.1 0.1 0.0017 18.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 EFW98802.1 - 0.00032 19.9 0.0 0.00056 19.1 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain AAA_25 PF13481.6 EFW98802.1 - 0.0023 17.5 0.1 0.55 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFW98802.1 - 0.0045 16.7 0.2 0.045 13.5 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 EFW98802.1 - 0.0047 16.5 0.0 0.0081 15.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EFW98802.1 - 0.0051 17.2 0.0 0.014 15.8 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EFW98802.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFW98802.1 - 0.015 15.0 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EFW98802.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFW98802.1 - 0.02 14.9 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFW98802.1 - 0.058 13.7 0.2 0.37 11.1 0.0 2.3 2 1 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 EFW98802.1 - 0.093 12.1 0.0 0.3 10.4 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TniB PF05621.11 EFW98802.1 - 0.12 11.8 0.1 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Rad17 PF03215.15 EFW98802.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain DEAD PF00270.29 EFW98803.1 - 3e-25 89.0 0.1 1.6e-13 50.8 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW98803.1 - 2.1e-20 73.1 0.0 4.5e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW98803.1 - 0.002 18.1 0.0 0.023 14.7 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit APH_6_hur PF04655.14 EFW98804.1 - 0.07 12.5 0.1 0.081 12.3 0.1 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase BMFP PF04380.13 EFW98805.1 - 0.094 13.2 0.1 1.2 9.6 0.0 2.5 2 0 0 2 2 2 0 Membrane fusogenic activity HMG_box PF00505.19 EFW98806.1 - 1.1e-05 25.8 0.0 3e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFW98806.1 - 0.00072 20.1 0.0 0.0026 18.3 0.0 2.0 1 0 0 1 1 1 1 HMG-box domain PKcGMP_CC PF16808.5 EFW98807.1 - 0.038 13.8 0.1 0.038 13.8 0.1 2.5 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SMN PF06003.12 EFW98808.1 - 0.25 10.6 1.7 0.33 10.2 1.7 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) SMC_N PF02463.19 EFW98809.1 - 1.6e-70 237.0 0.0 5.3e-70 235.3 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFW98809.1 - 1e-21 77.4 0.7 4.6e-21 75.3 0.2 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EFW98809.1 - 2e-09 38.3 18.7 2e-09 38.3 18.7 6.5 2 2 1 4 4 4 1 AAA domain AAA_21 PF13304.6 EFW98809.1 - 4.2e-09 36.6 4.5 0.00094 19.1 0.1 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFW98809.1 - 0.0011 18.7 0.1 0.0025 17.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Lebercilin PF15619.6 EFW98809.1 - 0.0073 16.0 10.7 0.0073 16.0 10.7 7.0 2 2 4 6 6 6 1 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 EFW98809.1 - 0.018 15.7 4.7 0.018 15.7 4.7 8.5 3 2 4 8 8 8 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HSBP1 PF06825.12 EFW98809.1 - 0.034 14.0 0.4 0.034 14.0 0.4 4.1 4 0 0 4 4 4 0 Heat shock factor binding protein 1 DUF4250 PF14056.6 EFW98809.1 - 0.3 11.0 3.0 1.4 8.9 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4250) HLH PF00010.26 EFW98810.1 - 3.3e-09 36.5 0.0 5e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1542 PF07564.11 EFW98810.1 - 0.037 14.1 1.7 0.59 10.3 0.5 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Umbravirus_LDM PF04817.12 EFW98810.1 - 0.041 13.3 0.2 0.043 13.2 0.2 1.1 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family Hydrolase_4 PF12146.8 EFW98811.1 - 0.02 14.2 0.0 0.045 13.0 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 EFW98811.1 - 0.041 13.4 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFW98811.1 - 0.049 13.3 0.1 0.086 12.5 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein WD40 PF00400.32 EFW98813.1 - 0.039 14.8 16.9 1.2 10.2 0.2 6.4 6 1 0 6 6 6 0 WD domain, G-beta repeat adh_short PF00106.25 EFW98814.1 - 2.5e-32 111.9 0.0 3.4e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW98814.1 - 1.2e-24 87.2 0.0 1.6e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFW98814.1 - 0.0027 17.2 0.0 0.012 15.1 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EFW98814.1 - 0.021 14.6 0.1 0.047 13.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase KR PF08659.10 EFW98814.1 - 0.064 13.2 0.7 1.3 8.9 0.7 2.5 1 1 0 1 1 1 0 KR domain Aldo_ket_red PF00248.21 EFW98815.1 - 1.2e-09 37.8 0.0 0.00046 19.5 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Peptidase_M24 PF00557.24 EFW98816.1 - 1.4e-49 168.6 0.1 1.8e-49 168.3 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EFW98816.1 - 8.3e-21 74.0 6.0 1.4e-20 73.3 6.0 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EFW98816.1 - 0.00024 21.1 2.7 0.00053 20.0 2.7 1.6 1 0 0 1 1 1 1 MYND finger ATP-cone PF03477.16 EFW98816.1 - 0.13 12.9 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 ATP cone domain Cpn60_TCP1 PF00118.24 EFW98817.1 - 7.5e-171 569.1 0.7 8.5e-171 568.9 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Aldedh PF00171.22 EFW98818.1 - 1e-86 291.3 0.0 1.3e-86 291.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PTPLA PF04387.14 EFW98819.1 - 3.4e-52 176.5 13.2 2.4e-50 170.5 8.9 2.2 1 1 1 2 2 2 2 Protein tyrosine phosphatase-like protein, PTPLA Glyco_hydro_16 PF00722.21 EFW98820.1 - 7.4e-11 41.8 0.0 1.4e-10 40.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SRP9-21 PF05486.12 EFW98821.1 - 2e-30 105.0 0.3 2e-30 105.0 0.3 1.7 2 0 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) CBFD_NFYB_HMF PF00808.23 EFW98822.1 - 1e-15 57.8 0.1 2.4e-15 56.6 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFW98822.1 - 0.00032 21.1 0.2 0.00068 20.0 0.0 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 GATase_2 PF00310.21 EFW98823.1 - 4.7e-180 598.8 0.0 6.2e-180 598.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EFW98823.1 - 4.8e-157 522.8 0.1 1.1e-156 521.6 0.0 1.7 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EFW98823.1 - 4.8e-113 377.3 0.0 7.5e-111 370.1 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EFW98823.1 - 6.2e-85 283.6 4.2 1e-84 282.9 4.2 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EFW98823.1 - 8.5e-25 87.6 0.1 1.2e-23 83.8 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EFW98823.1 - 9.4e-22 76.9 0.0 1.8e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EFW98823.1 - 1.9e-08 34.4 0.1 7.3e-08 32.5 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFW98823.1 - 1.1e-07 32.3 0.1 0.00024 21.6 0.1 3.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFW98823.1 - 1.5e-07 31.4 0.6 0.00076 19.2 0.2 2.8 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EFW98823.1 - 1.4e-06 27.9 0.2 2.5e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EFW98823.1 - 8.4e-06 25.2 0.7 0.047 12.9 0.1 3.6 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFW98823.1 - 4.3e-05 22.8 0.1 0.00022 20.4 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EFW98823.1 - 7.2e-05 21.7 0.3 7.2e-05 21.7 0.3 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EFW98823.1 - 9.8e-05 21.9 0.1 9.8e-05 21.9 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFW98823.1 - 0.00022 20.6 0.1 0.00048 19.5 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EFW98823.1 - 0.00074 18.9 0.1 0.11 11.8 0.1 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EFW98823.1 - 0.0029 18.0 1.4 1.2 9.6 0.1 3.1 3 0 0 3 3 2 1 Putative NAD(P)-binding FMO-like PF00743.19 EFW98823.1 - 0.012 14.0 0.1 1.2 7.4 0.0 2.7 2 1 1 3 3 3 0 Flavin-binding monooxygenase-like FMN_dh PF01070.18 EFW98823.1 - 0.021 13.8 0.4 0.12 11.4 0.5 2.1 3 0 0 3 3 3 0 FMN-dependent dehydrogenase GIDA PF01134.22 EFW98823.1 - 0.039 13.0 2.0 0.081 12.0 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFW98823.1 - 0.078 12.0 0.1 0.4 9.7 0.1 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein Thi4 PF01946.17 EFW98823.1 - 0.079 12.2 4.6 0.068 12.4 0.2 2.9 3 0 0 3 3 3 0 Thi4 family 2-Hacid_dh_C PF02826.19 EFW98823.1 - 0.094 12.1 0.1 0.6 9.4 0.0 2.3 3 0 0 3 3 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFW98823.1 - 0.14 11.8 0.1 0.52 9.9 0.1 2.0 2 0 0 2 2 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_9 PF13454.6 EFW98823.1 - 0.14 12.1 0.1 0.91 9.5 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 EFW98823.1 - 0.14 12.1 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 EFW98823.1 - 3.3 7.6 5.1 4.4 7.2 0.0 3.0 3 0 0 3 3 2 0 Rossmann-like domain DIOX_N PF14226.6 EFW98824.1 - 5.2e-20 72.4 0.0 8.2e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFW98824.1 - 2.4e-15 56.8 0.0 5.9e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3446 PF11928.8 EFW98825.1 - 0.28 11.5 8.1 0.63 10.4 8.1 1.7 1 1 0 1 1 1 0 Early growth response N-terminal domain Oxysterol_BP PF01237.18 EFW98826.1 - 1.4e-57 195.2 0.0 4.7e-55 186.9 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein PPTA PF01239.22 EFW98828.1 - 2.8e-06 26.9 10.6 0.001 18.7 0.3 3.1 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat Glyco_transf_34 PF05637.12 EFW98829.1 - 2.6e-64 217.2 0.0 3.5e-64 216.8 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family CFIA_Pcf11 PF11526.8 EFW98830.1 - 3.5e-06 27.4 0.0 7.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 zf-C2H2_4 PF13894.6 EFW98830.1 - 0.088 13.7 0.8 13 6.9 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf_UBZ PF18439.1 EFW98830.1 - 0.34 10.5 4.8 1.1 8.9 1.0 2.9 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 EFW98832.1 - 0.031 14.7 0.1 0.065 13.7 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type ANAPC4_WD40 PF12894.7 EFW98833.1 - 0.00027 21.2 0.0 0.52 10.6 0.0 4.4 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFW98833.1 - 0.00087 20.1 6.2 0.35 11.8 0.0 4.6 5 1 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EFW98833.1 - 0.17 10.9 0.0 0.39 9.6 0.0 1.6 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Condensation PF00668.20 EFW98834.1 - 0.00096 17.9 0.1 0.0011 17.8 0.1 1.0 1 0 0 1 1 1 1 Condensation domain Latrotoxin_C PF15658.6 EFW98834.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Latrotoxin C-terminal domain Ank_2 PF12796.7 EFW98835.1 - 1.7e-13 50.9 0.1 1.3e-06 28.9 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFW98835.1 - 1.6e-05 24.9 0.0 0.039 14.5 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFW98835.1 - 1.9e-05 24.9 0.1 0.066 13.7 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFW98835.1 - 0.00018 21.7 0.1 0.0056 17.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFW98835.1 - 0.026 15.1 0.1 0.44 11.2 0.0 2.7 1 1 2 3 3 3 0 Ankyrin repeats (many copies) Ish1 PF10281.9 EFW98835.1 - 0.071 13.4 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein XRCC4 PF06632.12 EFW98836.1 - 6.3e-09 35.1 10.5 6.3e-09 35.1 10.5 2.1 1 1 1 2 2 2 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 NOA36 PF06524.12 EFW98836.1 - 0.00082 18.8 8.3 0.0012 18.3 8.3 1.2 1 0 0 1 1 1 1 NOA36 protein DUF29 PF01724.16 EFW98836.1 - 0.01 16.1 3.1 0.017 15.3 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF29 PEP-utilisers_N PF05524.13 EFW98836.1 - 0.24 11.6 6.7 0.1 12.7 3.6 1.9 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Sas10_Utp3 PF04000.15 EFW98836.1 - 0.37 11.4 2.8 0.22 12.1 0.4 1.8 2 0 0 2 2 2 0 Sas10/Utp3/C1D family ORC5_C PF14630.6 EFW98837.1 - 1.9e-78 263.9 0.0 2.6e-78 263.4 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EFW98837.1 - 4.7e-17 62.9 0.5 8.7e-17 62.0 0.5 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFW98837.1 - 0.016 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFW98837.1 - 0.069 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein FGGY_C PF02782.16 EFW98839.1 - 1.5e-48 165.2 2.6 2.3e-48 164.6 2.6 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFW98839.1 - 4.9e-16 59.0 0.3 1.7e-14 54.0 0.3 2.8 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EFW98839.1 - 0.0027 17.3 0.4 0.004 16.7 0.1 1.6 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family HMGL-like PF00682.19 EFW98840.1 - 7.8e-78 261.7 0.0 1.1e-77 261.2 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EFW98840.1 - 9.7e-25 87.0 0.0 2.1e-24 85.9 0.0 1.6 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF1751 PF08551.10 EFW98841.1 - 1.8e-27 95.8 3.4 4.3e-27 94.6 3.4 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Cation_efflux PF01545.21 EFW98842.1 - 8.3e-21 74.6 13.1 1.1e-20 74.2 13.1 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFW98842.1 - 1.2e-06 28.5 0.1 2.3e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Cyclase PF04199.13 EFW98844.1 - 2e-14 54.0 0.0 2.6e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Mob1_phocein PF03637.17 EFW98845.1 - 8.6e-22 77.9 0.1 1.3e-21 77.3 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family CxC6 PF18721.1 EFW98845.1 - 0.11 12.8 3.0 0.22 11.8 3.0 1.4 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases DUF383 PF04063.14 EFW98846.1 - 4.3e-66 222.2 0.4 2.2e-65 219.9 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EFW98846.1 - 6.9e-21 73.8 1.4 6.9e-21 73.8 1.4 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF384) Trp_repressor PF01371.19 EFW98846.1 - 0.11 12.6 1.1 0.55 10.4 0.2 2.4 2 0 0 2 2 2 0 Trp repressor protein YTH PF04146.15 EFW98847.1 - 3.8e-62 209.1 0.0 1.2e-61 207.5 0.0 1.7 2 0 0 2 2 2 1 YT521-B-like domain RRM_1 PF00076.22 EFW98847.1 - 9.5e-06 25.4 0.3 8e-05 22.4 0.0 2.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFW98847.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif BSP_II PF05432.11 EFW98847.1 - 3.2 7.4 9.7 0.1 12.2 3.8 1.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TPR_1 PF00515.28 EFW98848.1 - 5.3e-54 178.0 35.1 2.4e-08 33.5 0.0 11.0 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 EFW98848.1 - 7.1e-47 153.8 26.3 8.5e-07 28.6 0.0 10.7 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFW98848.1 - 4e-39 129.6 23.9 5.5e-08 32.4 0.0 10.9 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_16 PF13432.6 EFW98848.1 - 1.1e-28 99.6 9.5 1.8e-07 31.7 0.0 6.6 3 2 2 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFW98848.1 - 5.4e-28 95.3 11.6 9.4e-05 22.9 0.0 9.2 3 2 6 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 EFW98848.1 - 1.1e-27 94.4 21.9 4.7e-05 23.5 0.0 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 EFW98848.1 - 6.9e-26 90.6 16.5 8e-05 23.1 0.1 7.0 5 1 3 8 8 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 EFW98848.1 - 1.2e-23 83.2 15.9 4e-05 23.8 0.9 7.5 4 3 2 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EFW98848.1 - 5.8e-23 79.9 18.2 0.00021 21.7 0.0 10.0 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFW98848.1 - 1.2e-21 76.1 34.1 2e-05 24.2 0.3 9.5 6 2 3 9 9 9 6 TPR repeat TPR_7 PF13176.6 EFW98848.1 - 7.6e-18 63.2 17.3 0.011 15.7 0.0 9.4 8 2 1 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 EFW98848.1 - 2.1e-17 63.0 10.4 0.0021 18.2 0.1 7.1 2 2 5 8 8 8 6 Tetratricopeptide repeat TPR_15 PF13429.6 EFW98848.1 - 6.4e-13 48.5 7.5 0.0038 16.5 1.2 5.0 1 1 1 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFW98848.1 - 4.7e-12 46.0 10.2 9e-09 35.4 1.9 3.7 4 1 1 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EFW98848.1 - 4.1e-09 36.4 4.5 0.0011 18.8 0.0 4.6 4 2 1 5 5 5 3 Tetratricopeptide repeat-like domain BTAD PF03704.17 EFW98848.1 - 0.00084 19.8 5.5 4.9 7.6 0.1 3.6 3 0 0 3 3 3 2 Bacterial transcriptional activator domain DUF2225 PF09986.9 EFW98848.1 - 0.0084 15.9 3.2 2 8.1 0.1 2.6 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 EFW98848.1 - 0.01 16.2 5.8 0.75 10.2 0.0 4.1 5 1 1 6 6 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFW98848.1 - 0.13 12.2 17.6 22 5.1 0.1 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat ChAPs PF09295.10 EFW98848.1 - 0.19 10.7 1.6 23 3.8 0.1 3.2 2 1 2 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.6 EFW98848.1 - 0.63 9.4 14.6 16 4.8 0.4 4.8 3 1 1 5 5 5 0 Soluble NSF attachment protein, SNAP DUF410 PF04190.13 EFW98848.1 - 0.89 9.3 4.2 0.92 9.3 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF410) RabGAP-TBC PF00566.18 EFW98849.1 - 2.2e-29 102.7 0.0 3.8e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain YchF-GTPase_C PF06071.13 EFW98850.1 - 2e-34 117.6 0.2 5.9e-34 116.1 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFW98850.1 - 1.7e-17 63.5 0.0 1.1e-16 61.0 0.0 2.1 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFW98850.1 - 0.00023 20.7 0.0 0.00049 19.7 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 EFW98850.1 - 0.0078 16.2 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 TGS domain AAA_14 PF13173.6 EFW98850.1 - 0.07 13.2 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain BetaGal_dom3 PF13363.6 EFW98850.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 HATPase_c_3 PF13589.6 EFW98852.1 - 2.7e-13 49.9 0.0 7.5e-13 48.5 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFW98852.1 - 2.3e-05 24.9 0.0 4.9e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EFW98852.1 - 0.0069 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain ERCC3_RAD25_C PF16203.5 EFW98853.1 - 2.4e-121 403.6 2.2 4.3e-121 402.8 2.2 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EFW98853.1 - 1.5e-33 115.6 0.0 6.4e-33 113.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW98853.1 - 2.5e-16 60.2 0.0 9.6e-16 58.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFW98853.1 - 2.4e-12 47.2 0.1 5.3e-12 46.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFW98853.1 - 8.7e-09 34.6 0.0 1.2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SBP_bac_6 PF13343.6 EFW98853.1 - 0.11 11.8 0.0 0.39 10.1 0.0 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein DAO PF01266.24 EFW98854.1 - 7.6e-51 173.7 9.1 9.4e-51 173.4 9.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFW98854.1 - 0.00048 20.3 0.9 0.0014 18.8 0.9 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFW98854.1 - 0.021 14.8 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EFW98854.1 - 0.17 12.5 0.2 0.34 11.5 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF5572 PF17733.1 EFW98855.1 - 5.2e-10 39.0 0.4 9.4e-10 38.2 0.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5572) HCV_NS4b PF01001.19 EFW98855.1 - 0.45 10.1 3.9 12 5.5 0.0 2.6 2 1 1 3 3 3 0 Hepatitis C virus non-structural protein NS4b NuiA PF07924.11 EFW98856.1 - 0.0002 21.8 0.1 0.0023 18.3 0.0 2.1 1 1 1 2 2 2 1 Nuclease A inhibitor-like protein Transp_cyt_pur PF02133.15 EFW98857.1 - 1.8e-17 63.2 37.1 3.4e-17 62.3 36.1 1.8 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sld5 PF05916.11 EFW98858.1 - 1.3e-17 64.2 0.0 2.4e-17 63.3 0.0 1.4 1 1 0 1 1 1 1 GINS complex protein Apc15p PF05841.11 EFW98859.1 - 2.6e-19 70.2 0.1 6.6e-19 68.9 0.1 1.7 1 0 0 1 1 1 1 Apc15p protein XPG_N PF00752.17 EFW98861.1 - 4.4e-33 113.8 0.0 1.4e-32 112.2 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EFW98861.1 - 6.6e-26 90.5 0.0 1.6e-25 89.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region UIM PF02809.20 EFW98861.1 - 0.00037 20.2 0.5 0.0025 17.6 0.5 2.6 1 0 0 1 1 1 1 Ubiquitin interaction motif Mid2 PF04478.12 EFW98862.1 - 4.5e-08 33.1 0.1 4.5e-08 33.1 0.1 2.4 3 0 0 3 3 3 1 Mid2 like cell wall stress sensor Yip1 PF04893.17 EFW98863.1 - 1.2e-13 51.2 12.0 2.2e-13 50.3 12.0 1.4 1 0 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 EFW98863.1 - 0.25 11.1 8.0 0.47 10.2 8.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) DUF2070 PF09843.9 EFW98863.1 - 8.5 4.5 6.6 12 4.1 6.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FAD_binding_3 PF01494.19 EFW98864.1 - 6.9e-74 249.2 0.0 8.6e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EFW98864.1 - 2.4e-40 138.3 0.0 3.9e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EFW98864.1 - 6.4e-05 22.3 0.0 0.0053 16.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFW98864.1 - 0.00015 22.2 0.0 0.0014 19.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFW98864.1 - 0.0017 18.0 1.8 0.1 12.1 0.1 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFW98864.1 - 0.0034 17.6 0.0 0.032 14.4 0.0 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain XdhC_C PF13478.6 EFW98864.1 - 0.018 15.6 0.0 0.036 14.6 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain HI0933_like PF03486.14 EFW98864.1 - 0.038 12.7 0.0 0.075 11.7 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein GDI PF00996.18 EFW98864.1 - 0.046 12.2 0.0 0.069 11.7 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Thi4 PF01946.17 EFW98864.1 - 0.064 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.18 EFW98864.1 - 0.065 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EFW98864.1 - 0.089 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 EFW98864.1 - 0.11 11.6 0.0 0.24 10.4 0.0 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein Lung_7-TM_R PF06814.13 EFW98865.1 - 2.1e-65 220.9 16.3 2.7e-65 220.6 16.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF1980 PF09323.10 EFW98865.1 - 0.047 13.6 1.5 0.12 12.3 1.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) EMP24_GP25L PF01105.24 EFW98865.1 - 0.16 11.9 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Ras PF00071.22 EFW98866.1 - 3e-48 163.5 0.0 1.8e-37 128.4 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFW98866.1 - 5.8e-27 94.3 0.0 1.5e-17 64.0 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFW98866.1 - 2.3e-08 33.7 0.0 9.7e-08 31.7 0.0 1.9 2 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFW98866.1 - 0.00048 19.7 0.0 0.0017 17.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFW98866.1 - 0.00048 20.2 0.0 0.0052 16.9 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFW98866.1 - 0.0038 16.6 0.0 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFW98866.1 - 0.043 13.7 0.0 0.82 9.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EFW98866.1 - 0.11 12.8 0.1 0.97 9.7 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EFW98866.1 - 0.16 12.1 0.6 8.1 6.6 0.1 2.6 1 1 1 2 2 2 0 AAA domain ACBP PF00887.19 EFW98867.1 - 1.6e-23 82.7 0.0 2.8e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Zip PF02535.22 EFW98868.1 - 1.7 7.8 7.6 6.2 5.9 0.7 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2752 PF10825.8 EFW98868.1 - 9.2 6.4 6.8 0.65 10.1 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2752) AMP-binding PF00501.28 EFW98872.1 - 1.4e-88 297.3 0.0 1.8e-88 297.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFW98872.1 - 1.2e-27 96.7 0.9 2e-26 92.8 0.6 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EFW98872.1 - 1.6e-17 63.2 0.0 9.9e-17 60.6 0.1 2.4 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Ras PF00071.22 EFW98873.1 - 2.2e-58 196.4 0.2 2.5e-58 196.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFW98873.1 - 6.2e-36 123.2 0.1 1e-35 122.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFW98873.1 - 2.5e-15 56.4 0.0 3e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFW98873.1 - 3.2e-07 30.1 0.0 4.2e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFW98873.1 - 4.5e-07 29.5 0.0 5.3e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFW98873.1 - 6.5e-07 29.4 0.0 2.8e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFW98873.1 - 8.6e-06 25.7 1.0 0.12 12.2 0.0 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EFW98873.1 - 0.022 15.2 0.3 0.041 14.3 0.3 1.6 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 EFW98873.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 EFW98873.1 - 0.14 12.4 0.1 3.2 8.0 0.1 2.3 1 1 0 1 1 1 0 AAA domain Metallophos_2 PF12850.7 EFW98876.1 - 4.4e-12 46.5 0.0 5.5e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFW98876.1 - 0.16 12.5 0.0 9.2 6.7 0.0 2.2 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase APS_kinase PF01583.20 EFW98877.1 - 0.0018 18.2 0.1 1.4 8.8 0.0 2.3 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_33 PF13671.6 EFW98877.1 - 0.0049 17.0 0.1 0.0081 16.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFW98877.1 - 0.022 15.3 0.0 0.062 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 EFW98878.1 - 2.4e-77 259.2 0.0 3.2e-77 258.8 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFW98878.1 - 3.4e-32 111.7 0.0 5.3e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFW98878.1 - 2.5e-05 24.5 0.0 4.4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EFW98878.1 - 4.6e-05 23.0 0.0 6.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Pescadillo_N PF06732.11 EFW98879.1 - 2e-120 401.4 0.0 2e-120 401.4 0.0 1.6 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT PF00533.26 EFW98879.1 - 0.00014 22.2 0.0 0.00072 19.9 0.0 2.3 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFW98879.1 - 0.026 14.9 0.0 0.12 12.8 0.0 2.1 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain DUF1168 PF06658.12 EFW98881.1 - 3.2e-32 111.2 11.1 3.2e-32 111.2 11.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) DUF390 PF04094.14 EFW98881.1 - 0.061 11.6 17.3 0.083 11.2 17.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF390) DUF966 PF06136.13 EFW98881.1 - 0.37 10.5 6.7 0.44 10.2 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Alpha_GJ PF03229.13 EFW98881.1 - 2 9.0 10.8 0.56 10.8 7.0 2.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J DUF4407 PF14362.6 EFW98881.1 - 6.5 6.0 8.5 8.2 5.7 8.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MDM31_MDM32 PF08118.11 EFW98883.1 - 0.062 12.0 1.2 0.089 11.5 1.2 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FAD-oxidase_C PF02913.19 EFW98883.1 - 0.3 10.7 8.0 0.5 10.0 8.0 1.2 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain FUSC PF04632.12 EFW98883.1 - 6.2 5.2 21.2 8.7 4.7 21.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family MFS_1 PF07690.16 EFW98884.1 - 2.8e-29 102.1 26.9 3.8e-29 101.7 26.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 EFW98885.1 - 2.3e-38 131.3 0.0 1.5e-37 128.6 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFW98885.1 - 0.00011 21.9 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Bac_rhodopsin PF01036.18 EFW98887.1 - 1.2e-26 93.7 24.1 1.7e-26 93.2 24.1 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF1349 PF07081.11 EFW98888.1 - 1.1e-23 83.9 0.0 1.3e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Pkinase PF00069.25 EFW98889.1 - 2.9e-50 171.1 0.1 1.1e-49 169.2 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW98889.1 - 2.8e-23 82.5 0.0 5.9e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFW98889.1 - 0.00041 20.3 0.1 0.00041 20.3 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFW98889.1 - 0.0085 15.7 0.2 0.0085 15.7 0.2 2.0 2 1 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EFW98889.1 - 0.29 10.7 1.3 0.45 10.1 0.2 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF3614 PF12267.8 EFW98889.1 - 0.61 10.6 3.2 2 8.9 3.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) Thi4 PF01946.17 EFW98890.1 - 2.1e-113 377.4 0.2 2.6e-113 377.1 0.2 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EFW98890.1 - 2.2e-06 27.5 3.6 3.1e-06 27.0 2.3 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFW98890.1 - 1.6e-05 25.0 0.9 4.5e-05 23.6 0.9 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFW98890.1 - 0.00022 20.5 3.2 0.001 18.3 0.8 2.4 2 1 1 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.14 EFW98890.1 - 0.00026 20.3 0.1 0.00034 19.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFW98890.1 - 0.00071 18.7 1.0 0.0016 17.6 0.4 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EFW98890.1 - 0.0012 18.9 0.2 0.0049 16.9 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFW98890.1 - 0.014 14.7 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFW98890.1 - 0.033 13.3 0.1 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFW98890.1 - 0.038 13.4 0.6 0.061 12.7 0.6 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EFW98890.1 - 0.061 12.0 0.5 0.095 11.4 0.5 1.2 1 0 0 1 1 1 0 HI0933-like protein Mqo PF06039.15 EFW98890.1 - 0.14 10.7 0.0 0.21 10.1 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Hpt PF01627.23 EFW98891.1 - 3.9e-12 46.3 0.2 8.3e-12 45.2 0.0 1.6 2 0 0 2 2 2 1 Hpt domain MOZART1 PF12554.8 EFW98892.1 - 1.1e-22 79.5 0.7 1.3e-22 79.3 0.7 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated G-alpha PF00503.20 EFW98893.1 - 3.1e-125 418.0 2.2 3.5e-125 417.8 2.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFW98893.1 - 1.7e-15 56.9 1.0 2.7e-10 40.0 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EFW98893.1 - 0.00088 19.0 0.0 0.0038 17.0 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 EFW98893.1 - 0.0035 16.7 2.3 0.22 10.8 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EFW98893.1 - 0.018 14.8 0.0 0.043 13.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EFW98893.1 - 0.028 14.6 0.1 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EFW98893.1 - 0.041 13.0 0.1 0.074 12.1 0.1 1.4 1 1 0 1 1 1 0 MCM P-loop domain GTP_EFTU PF00009.27 EFW98893.1 - 0.09 12.3 0.0 0.96 9.0 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 EFW98893.1 - 0.094 12.1 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Septin PF00735.18 EFW98894.1 - 1.8e-13 50.5 0.0 5.5e-10 39.0 0.0 2.5 3 0 0 3 3 3 2 Septin MMR_HSR1 PF01926.23 EFW98894.1 - 0.0009 19.3 0.0 0.0089 16.1 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Sigma54_activat PF00158.26 EFW98894.1 - 0.0021 17.8 0.0 0.99 9.1 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 EFW98894.1 - 0.0066 16.4 0.0 0.027 14.5 0.0 2.0 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 EFW98894.1 - 0.037 13.8 0.4 1.4 8.7 0.3 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Roc PF08477.13 EFW98894.1 - 0.057 13.6 0.0 0.18 12.0 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 EFW98894.1 - 0.068 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFW98894.1 - 0.077 12.9 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase DUF815 PF05673.13 EFW98894.1 - 0.095 11.8 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFW98894.1 - 0.11 12.1 0.0 0.46 10.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 EFW98894.1 - 0.11 13.1 0.1 0.31 11.5 0.0 1.8 2 0 0 2 2 1 0 ABC transporter NACHT PF05729.12 EFW98894.1 - 0.12 12.3 0.3 0.52 10.2 0.1 2.1 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 EFW98894.1 - 0.22 12.0 0.0 0.44 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 EFW98894.1 - 0.25 10.4 0.0 0.46 9.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Lon_C PF05362.13 EFW98895.1 - 9.4e-65 218.0 0.0 1.9e-64 217.0 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EFW98895.1 - 1.7e-22 80.3 0.1 5.5e-22 78.6 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EFW98895.1 - 1.9e-20 73.7 0.0 5.9e-20 72.0 0.0 1.9 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 EFW98895.1 - 2.1e-07 31.0 0.6 1e-06 28.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EFW98895.1 - 5.2e-07 29.5 0.0 1.2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EFW98895.1 - 3.5e-06 27.5 2.6 4.9e-06 27.0 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EFW98895.1 - 4.4e-05 23.3 0.0 9.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EFW98895.1 - 0.00014 21.7 0.0 0.00032 20.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFW98895.1 - 0.00015 21.6 0.1 0.00054 19.7 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFW98895.1 - 0.00034 20.9 0.0 0.0072 16.6 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFW98895.1 - 0.0039 17.4 1.3 0.011 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EFW98895.1 - 0.0044 16.5 0.0 0.017 14.6 0.0 1.9 2 0 0 2 2 2 1 Bacterial TniB protein Rad17 PF03215.15 EFW98895.1 - 0.0058 16.6 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_2 PF07724.14 EFW98895.1 - 0.0086 16.2 1.6 0.045 13.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EFW98895.1 - 0.011 15.8 0.0 0.04 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 EFW98895.1 - 0.012 14.9 0.1 0.023 13.9 0.1 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain RsgA_GTPase PF03193.16 EFW98895.1 - 0.015 15.2 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EFW98895.1 - 0.023 14.3 0.1 0.061 12.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFW98895.1 - 0.034 14.7 0.0 0.093 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFW98895.1 - 0.036 13.3 0.0 0.074 12.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.17 EFW98895.1 - 0.036 14.1 0.0 0.086 12.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFW98895.1 - 0.05 13.1 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFW98895.1 - 0.058 13.8 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EFW98895.1 - 0.06 13.3 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.21 EFW98895.1 - 0.11 11.9 0.2 0.28 10.5 0.1 1.7 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI DUF4407 PF14362.6 EFW98895.1 - 0.15 11.3 4.8 0.28 10.5 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_23 PF13476.6 EFW98895.1 - 0.28 11.6 7.2 1.7 9.1 0.0 2.6 1 1 1 2 2 2 0 AAA domain T3SSipB PF16535.5 EFW98895.1 - 0.84 10.1 12.5 0.93 10.0 7.7 2.3 2 0 0 2 2 2 0 Type III cell invasion protein SipB AAA_17 PF13207.6 EFW98895.1 - 0.96 9.9 3.2 0.94 9.9 0.1 2.6 2 0 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 EFW98895.1 - 1.1 8.7 6.4 2 7.9 6.4 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4337 PF14235.6 EFW98895.1 - 1.6 8.8 7.8 3.1 7.9 7.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) ABC_tran PF00005.27 EFW98895.1 - 3 8.4 5.9 3 8.3 0.1 2.6 1 1 1 2 2 2 0 ABC transporter MFS_1 PF07690.16 EFW98896.1 - 3.5e-15 55.8 51.2 4.3e-14 52.2 50.6 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Fringe PF02434.16 EFW98897.1 - 1.2e-05 24.9 0.0 9.3e-05 22.0 0.0 2.0 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EFW98897.1 - 0.018 14.9 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase Methyltransf_25 PF13649.6 EFW98898.1 - 4.4e-12 46.5 0.0 7e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW98898.1 - 8.9e-11 42.3 0.0 1.5e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW98898.1 - 1.1e-08 35.1 0.0 1.7e-08 34.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW98898.1 - 1.7e-07 31.1 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW98898.1 - 2.3e-07 31.5 0.0 3.9e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFW98898.1 - 0.012 14.5 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.20 EFW98898.1 - 0.055 12.8 0.0 0.07 12.4 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 EFW98898.1 - 0.12 12.0 0.0 0.46 10.0 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Glyco_hydro_cc PF11790.8 EFW98899.1 - 1.7e-58 198.0 3.5 2.6e-58 197.4 3.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core BCNT PF07572.12 EFW98901.1 - 2.2e-20 72.5 0.3 4.3e-20 71.6 0.3 1.5 1 0 0 1 1 1 1 Bucentaur or craniofacial development CDC45 PF02724.14 EFW98901.1 - 4.4 5.5 9.4 6.5 4.9 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Mlh1_C PF16413.5 EFW98903.1 - 4.2e-91 305.1 0.0 6.4e-91 304.5 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EFW98903.1 - 6.5e-30 103.2 0.0 1e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFW98903.1 - 1.6e-09 37.7 0.0 2.9e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFW98903.1 - 7.9e-07 29.6 0.0 1.5e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Thioredoxin_8 PF13905.6 EFW98903.1 - 0.011 16.0 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like OPT PF03169.15 EFW98904.1 - 2.3e-142 475.8 30.3 2.6e-142 475.6 30.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Hydrolase_4 PF12146.8 EFW98904.1 - 0.038 13.3 0.1 0.086 12.1 0.1 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RNase_PH PF01138.21 EFW98905.1 - 1.2e-14 54.9 0.1 5.8e-14 52.7 0.1 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFW98905.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 TPR_4 PF07721.14 EFW98905.1 - 0.77 10.6 6.4 0.3 11.8 3.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_1 PF00076.22 EFW98906.1 - 6.1e-11 42.0 0.1 2.1e-07 30.7 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Activator-TraM PF11657.8 EFW98906.1 - 0.32 10.8 6.7 0.78 9.6 6.7 1.6 1 0 0 1 1 1 0 Transcriptional activator TraM NOA36 PF06524.12 EFW98906.1 - 0.89 8.8 5.8 1.5 8.0 5.8 1.3 1 0 0 1 1 1 0 NOA36 protein Mito_carr PF00153.27 EFW98907.1 - 6.4e-40 135.0 8.7 2.4e-15 56.2 0.3 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Complex1_LYR PF05347.15 EFW98907.1 - 0.048 13.7 0.4 0.13 12.3 0.4 1.7 1 0 0 1 1 1 0 Complex 1 protein (LYR family) Ank_2 PF12796.7 EFW98908.1 - 5.3e-22 78.2 0.1 5.8e-11 42.8 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Methyltransf_23 PF13489.6 EFW98908.1 - 1.6e-16 60.6 0.2 4.4e-16 59.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ank_4 PF13637.6 EFW98908.1 - 2e-11 44.2 0.1 2.9e-09 37.3 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Methyltransf_25 PF13649.6 EFW98908.1 - 4e-11 43.5 0.0 2e-10 41.3 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Ank PF00023.30 EFW98908.1 - 5.1e-10 39.3 0.0 3.3e-07 30.5 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EFW98908.1 - 2.4e-09 37.3 0.0 6.6e-07 29.5 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Methyltransf_11 PF08241.12 EFW98908.1 - 7.5e-08 32.9 0.0 2.9e-07 31.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Ank_3 PF13606.6 EFW98908.1 - 2.8e-07 30.3 0.0 2.3e-05 24.4 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Methyltransf_12 PF08242.12 EFW98908.1 - 3.1e-06 27.9 0.0 4.8e-05 24.0 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW98908.1 - 6.7e-06 26.0 0.3 4.9e-05 23.2 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EFW98908.1 - 0.00059 20.0 0.2 0.011 15.9 0.0 2.3 2 0 0 2 2 2 1 FtsJ-like methyltransferase MTS PF05175.14 EFW98908.1 - 0.0011 18.6 0.0 0.0028 17.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain Golgin_A5 PF09787.9 EFW98908.1 - 0.0011 18.5 18.2 0.0019 17.8 18.2 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Methyltransf_4 PF02390.17 EFW98908.1 - 0.0018 17.8 0.0 0.0048 16.4 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EFW98908.1 - 0.0065 15.9 0.0 0.0065 15.9 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EFW98908.1 - 0.053 12.8 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family ALMT PF11744.8 EFW98908.1 - 1 8.1 6.7 1.7 7.4 6.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Atg14 PF10186.9 EFW98908.1 - 1.6 7.7 12.5 2.5 7.1 12.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAD-oxidase_C PF02913.19 EFW98909.1 - 3.4e-61 207.1 0.0 4.9e-61 206.5 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFW98909.1 - 9.1e-37 125.9 0.2 1.7e-36 125.0 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain DUF5327 PF17261.2 EFW98910.1 - 0.63 10.8 7.3 2.7 8.8 1.8 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5327) Na_Ca_ex PF01699.24 EFW98911.1 - 2.2e-07 30.9 33.0 0.0001 22.3 12.0 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Proteasome PF00227.26 EFW98912.1 - 3.4e-28 98.4 0.2 7.3e-28 97.4 0.2 1.5 1 1 0 1 1 1 1 Proteasome subunit PI3_PI4_kinase PF00454.27 EFW98913.1 - 4.8e-39 134.7 0.1 1.1e-36 127.0 0.1 2.7 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFW98913.1 - 1.3e-22 80.1 0.0 3.4e-22 78.7 0.0 1.7 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF829 PF05705.14 EFW98914.1 - 2.5e-38 132.3 0.0 3.4e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) HTH_12 PF08461.10 EFW98915.1 - 0.027 14.4 0.0 3.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain HTH_Tnp_1 PF01527.20 EFW98915.1 - 0.34 11.3 2.1 2 8.8 0.0 2.9 3 1 0 3 3 3 0 Transposase ORC6 PF05460.13 EFW98915.1 - 0.51 9.6 4.9 0.78 8.9 4.9 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Pox_Ag35 PF03286.14 EFW98915.1 - 8.6 6.1 9.5 13 5.5 9.2 1.4 1 1 0 1 1 1 0 Pox virus Ag35 surface protein GCFC PF07842.12 EFW98916.1 - 3.9e-60 203.8 7.3 3.9e-60 203.8 7.3 1.8 1 1 1 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EFW98916.1 - 2.4e-14 52.9 1.2 2.4e-14 52.9 1.2 2.1 2 0 0 2 2 2 1 G-patch domain TIP_N PF12457.8 EFW98916.1 - 5.2e-10 39.6 5.8 5.2e-10 39.6 5.8 2.7 2 1 1 3 3 2 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 EFW98916.1 - 2.6e-07 30.6 1.2 8.6e-07 29.0 1.2 1.9 1 0 0 1 1 1 1 G-patch domain CLASP_N PF12348.8 EFW98916.1 - 0.00039 20.0 0.1 0.011 15.4 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal Cnd1 PF12717.7 EFW98916.1 - 0.0021 18.1 0.1 0.047 13.7 0.0 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EFW98916.1 - 0.0046 15.6 0.1 2 6.9 0.0 2.2 2 0 0 2 2 2 2 Adaptin N terminal region TAN PF11640.8 EFW98916.1 - 0.011 15.9 0.1 0.042 14.0 0.1 2.0 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Cep57_CLD_2 PF14197.6 EFW98916.1 - 0.012 15.7 17.3 0.41 10.8 6.7 3.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Syntaxin PF00804.25 EFW98916.1 - 0.013 15.2 2.5 0.078 12.6 1.7 2.6 2 0 0 2 2 2 0 Syntaxin HEAT PF02985.22 EFW98916.1 - 0.067 13.5 0.9 2.8 8.5 0.1 3.8 4 0 0 4 4 2 0 HEAT repeat PilX PF13681.6 EFW98916.1 - 0.076 13.4 0.0 0.28 11.6 0.0 1.9 1 0 0 1 1 1 0 Type IV pilus assembly protein PilX C-term HALZ PF02183.18 EFW98916.1 - 0.3 11.3 12.9 0.19 12.0 3.9 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper TMCO5 PF14992.6 EFW98916.1 - 1.9 8.0 6.3 4.2 6.9 6.3 1.4 1 0 0 1 1 1 0 TMCO5 family SHE3 PF17078.5 EFW98916.1 - 2.1 8.0 9.7 6.3 6.4 9.7 1.8 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Sec2p PF06428.11 EFW98916.1 - 8.2 6.5 12.3 18 5.4 0.1 4.0 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p LysM PF01476.20 EFW98917.1 - 3e-07 30.4 0.0 0.0015 18.5 0.0 2.4 2 0 0 2 2 2 2 LysM domain DEAD PF00270.29 EFW98918.1 - 5.7e-25 88.1 0.0 1.7e-24 86.5 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EFW98918.1 - 4e-18 66.0 1.7 1.3e-17 64.3 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EFW98918.1 - 4.8e-10 39.8 0.0 3e-09 37.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ran_BP1 PF00638.18 EFW98918.1 - 3.1e-09 37.1 0.2 0.00027 21.2 0.0 2.3 2 0 0 2 2 2 2 RanBP1 domain DUF3246 PF11596.8 EFW98918.1 - 6.4 6.1 9.2 7.7 5.9 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) Fungal_trans PF04082.18 EFW98919.1 - 4.3e-24 85.0 0.0 6.6e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Herpes_UL6 PF01763.16 EFW98920.1 - 0.014 13.9 0.5 0.028 13.0 0.4 1.5 1 1 0 1 1 1 0 Herpesvirus UL6 like HSCB_C PF07743.13 EFW98920.1 - 0.018 15.5 3.3 0.034 14.6 0.8 2.2 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain CCDC-167 PF15188.6 EFW98920.1 - 0.17 12.2 0.3 0.17 12.2 0.3 2.0 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 Sec2p PF06428.11 EFW98920.1 - 0.42 10.6 3.4 3 7.9 3.4 2.3 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p Transposase_24 PF03004.14 EFW98920.1 - 0.8 9.8 5.2 7.2 6.7 0.1 2.5 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) Fib_alpha PF08702.10 EFW98920.1 - 1.1 9.5 4.1 2.1 8.5 4.1 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3040 PF11239.8 EFW98920.1 - 8 6.8 5.7 2.2 8.6 0.9 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) PIF1 PF05970.14 EFW98921.1 - 4.9e-34 118.1 0.0 1.6e-22 80.2 0.0 3.3 3 0 0 3 3 3 3 PIF1-like helicase AAA_30 PF13604.6 EFW98921.1 - 1.6e-20 73.7 0.0 6.4e-20 71.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFW98921.1 - 3.9e-12 46.7 0.0 8.8e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 EFW98921.1 - 1.9e-07 29.4 0.5 2.4e-06 25.8 0.0 2.3 3 0 0 3 3 3 1 Helicase UvrD_C_2 PF13538.6 EFW98921.1 - 9.5e-07 28.6 1.1 1.7e-06 27.7 0.1 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 EFW98921.1 - 4.9e-05 23.6 0.0 0.00011 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFW98921.1 - 0.00016 21.5 0.3 0.7 9.6 0.0 2.8 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 EFW98921.1 - 0.00072 19.6 0.0 0.0016 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFW98921.1 - 0.0057 17.2 0.4 0.096 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EFW98921.1 - 0.0066 16.4 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase NTPase_1 PF03266.15 EFW98921.1 - 0.012 15.5 0.0 5 7.0 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_29 PF13555.6 EFW98921.1 - 0.017 14.9 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EFW98921.1 - 0.019 14.7 0.1 0.62 9.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 EFW98921.1 - 0.019 15.4 0.1 0.057 13.8 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFW98921.1 - 0.026 15.1 0.0 0.067 13.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA PF00004.29 EFW98921.1 - 0.034 14.6 0.0 0.065 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EFW98921.1 - 0.034 13.6 0.0 0.064 12.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Rad17 PF03215.15 EFW98921.1 - 0.041 13.8 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_11 PF13086.6 EFW98921.1 - 0.048 13.4 0.3 16 5.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EFW98921.1 - 0.059 13.5 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFW98921.1 - 0.077 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DEAD PF00270.29 EFW98921.1 - 0.089 12.5 0.1 0.44 10.3 0.1 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_7 PF12775.7 EFW98921.1 - 0.096 12.2 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Helicase_RecD PF05127.14 EFW98921.1 - 0.12 12.2 0.5 0.65 9.8 0.1 2.4 2 1 0 2 2 2 0 Helicase DUF1899 PF08953.11 EFW98922.1 - 1.4e-34 117.7 0.0 2.5e-34 117.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EFW98922.1 - 1.2e-18 66.7 0.1 2.5e-18 65.7 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EFW98922.1 - 2.4e-14 53.5 5.1 0.00011 22.9 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW98922.1 - 7.8e-08 32.5 0.2 0.038 14.3 0.0 3.6 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFW98922.1 - 0.0003 19.6 1.5 0.21 10.2 0.1 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EFW98922.1 - 0.0017 18.2 0.0 0.0055 16.6 0.0 1.7 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Med21 PF11221.8 EFW98922.1 - 0.029 14.6 1.2 0.029 14.6 1.2 2.3 2 1 0 2 2 2 0 Subunit 21 of Mediator complex SlyX PF04102.12 EFW98922.1 - 1.6 9.4 4.8 0.36 11.5 1.0 1.8 2 0 0 2 2 2 0 SlyX UPF0061 PF02696.14 EFW98923.1 - 1.2e-117 393.6 0.0 3.7e-117 392.0 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family HSP70 PF00012.20 EFW98924.1 - 5.2e-267 886.9 16.5 6.1e-267 886.7 16.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFW98924.1 - 5.1e-15 55.1 5.4 6.6e-13 48.2 1.5 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EFW98924.1 - 2.4e-06 27.4 0.1 0.00097 18.9 0.0 2.6 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, C-terminal domain Tom22 PF04281.13 EFW98924.1 - 0.13 12.1 6.7 0.3 10.9 6.7 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 cwf21 PF08312.12 EFW98924.1 - 0.28 11.4 3.4 10 6.4 0.7 3.3 3 1 0 3 3 3 0 cwf21 domain SMBP PF16785.5 EFW98924.1 - 0.41 10.9 5.7 0.24 11.6 3.1 2.1 2 0 0 2 2 2 0 Small metal-binding protein Med9 PF07544.13 EFW98924.1 - 0.72 10.0 6.2 1.3 9.2 1.0 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Maf PF02545.14 EFW98925.1 - 2e-45 154.6 0.1 3.6e-45 153.8 0.1 1.4 1 0 0 1 1 1 1 Maf-like protein DUF1980 PF09323.10 EFW98925.1 - 0.092 12.6 5.7 0.18 11.7 5.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) FTA2 PF13095.6 EFW98925.1 - 0.094 12.3 2.5 0.18 11.4 2.5 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Rxt3 PF08642.10 EFW98925.1 - 0.13 13.0 2.8 0.45 11.3 2.8 1.9 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 DDHD PF02862.17 EFW98925.1 - 0.14 12.3 5.0 0.075 13.2 1.7 2.1 2 0 0 2 2 2 0 DDHD domain FHIPEP PF00771.20 EFW98925.1 - 0.17 10.3 2.2 0.27 9.6 2.2 1.2 1 0 0 1 1 1 0 FHIPEP family SPG4 PF17325.2 EFW98925.1 - 0.27 12.3 6.1 1 10.4 6.1 1.9 1 0 0 1 1 1 0 Stationary phase protein 4 eIF-3_zeta PF05091.12 EFW98925.1 - 0.52 9.2 10.4 1.1 8.2 10.4 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 EFW98925.1 - 1 8.8 8.5 1.8 8.0 8.5 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) HA2 PF04408.23 EFW98925.1 - 1.5 9.1 4.7 6.5 7.1 3.6 2.6 2 0 0 2 2 2 0 Helicase associated domain (HA2) Ctr PF04145.15 EFW98925.1 - 1.7 9.2 3.9 14 6.3 3.6 2.5 2 0 0 2 2 2 0 Ctr copper transporter family Tim54 PF11711.8 EFW98925.1 - 2.8 6.6 9.8 5 5.8 9.8 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Band_3_cyto PF07565.13 EFW98925.1 - 4.7 6.9 7.7 9.7 5.9 7.7 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MDM10 PF12519.8 EFW98925.1 - 5.8 5.7 6.6 9.8 4.9 6.6 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PAT1 PF09770.9 EFW98925.1 - 6.1 5.0 26.9 9.4 4.4 26.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 EFW98925.1 - 9.1 5.2 10.5 18 4.2 10.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Connexin PF00029.19 EFW98925.1 - 9.2 5.9 7.5 17 5.0 6.0 2.0 2 0 0 2 2 2 0 Connexin Neur_chan_memb PF02932.16 EFW98925.1 - 9.3 6.2 8.4 0.5 10.4 2.4 2.0 2 0 0 2 2 1 0 Neurotransmitter-gated ion-channel transmembrane region RCC1_2 PF13540.6 EFW98926.1 - 1.7e-13 50.0 7.5 6.4e-05 22.6 0.4 4.3 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFW98926.1 - 4.3e-12 46.5 6.0 1.6e-06 28.6 0.0 4.8 4 2 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat SUIM_assoc PF16619.5 EFW98927.1 - 0.0041 17.2 0.4 0.032 14.3 0.5 2.3 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Fungal_trans PF04082.18 EFW98927.1 - 0.016 14.3 0.0 0.076 12.0 0.0 2.1 2 0 0 2 2 2 0 Fungal specific transcription factor domain CTD_bind PF04818.13 EFW98928.1 - 2.5e-08 34.6 0.0 4.6e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 EFW98928.1 - 1.6e-05 24.6 0.0 3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFW98928.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif RPA_C PF08784.11 EFW98929.1 - 3e-12 47.1 0.7 4.4e-12 46.6 0.1 1.6 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EFW98929.1 - 8.6e-08 32.1 0.1 5.8e-07 29.4 0.0 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Ribosomal_S6e PF01092.19 EFW98930.1 - 2.2e-58 195.7 0.0 3.8e-58 194.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Sugar_tr PF00083.24 EFW98931.1 - 6.6e-106 354.9 9.5 1.4e-104 350.5 9.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_72 PF03198.14 EFW98931.1 - 4.7e-101 338.2 0.0 6.8e-101 337.6 0.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase MFS_1 PF07690.16 EFW98931.1 - 2.5e-24 85.9 50.5 3.2e-23 82.2 26.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_2_C PF02836.17 EFW98931.1 - 0.00069 18.8 0.0 0.0011 18.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain SAPS PF04499.15 EFW98932.1 - 7.9e-190 631.8 0.0 3.8e-189 629.6 0.0 1.8 1 1 0 1 1 1 1 SIT4 phosphatase-associated protein Pil1 PF13805.6 EFW98933.1 - 4.8e-128 426.2 0.1 6.3e-128 425.8 0.1 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 NOA36 PF06524.12 EFW98933.1 - 1.9 7.7 6.2 3.5 6.9 6.2 1.3 1 0 0 1 1 1 0 NOA36 protein Rotamase_3 PF13616.6 EFW98934.1 - 1.5e-16 60.9 0.1 3.1e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EFW98934.1 - 1.3e-15 58.1 0.0 2.6e-15 57.2 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Ctf8 PF09696.10 EFW98936.1 - 3.6e-39 134.3 0.0 5.7e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Ctf8 HOOK PF05622.12 EFW98937.1 - 4.3e-11 41.7 25.6 4.3e-11 41.7 25.6 4.4 2 2 1 3 3 3 2 HOOK protein CH_2 PF06294.11 EFW98937.1 - 0.0082 16.2 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 CH-like domain in sperm protein GCP_N_terminal PF17681.1 EFW98937.1 - 0.076 12.6 7.8 0.01 15.5 2.8 2.0 2 0 0 2 2 2 0 Gamma tubulin complex component N-terminal DUF639 PF04842.12 EFW98937.1 - 0.23 10.8 0.7 0.57 9.5 0.7 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Hamartin PF04388.12 EFW98938.1 - 0.0039 15.9 5.0 0.0044 15.8 5.0 1.0 1 0 0 1 1 1 1 Hamartin protein Plasmodium_Vir PF05795.11 EFW98938.1 - 0.2 11.1 5.1 0.24 10.8 5.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Menin PF05053.13 EFW98938.1 - 0.2 10.0 7.4 0.23 9.8 7.4 1.0 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.16 EFW98938.1 - 0.65 10.0 3.2 0.75 9.8 3.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 EFW98938.1 - 0.67 9.7 6.6 0.79 9.5 6.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PGA2 PF07543.12 EFW98938.1 - 0.7 9.9 9.9 1.3 9.0 9.9 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 ORC6 PF05460.13 EFW98938.1 - 8.7 5.5 15.2 12 5.0 12.3 1.9 1 1 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) CENP-H PF05837.12 EFW98938.1 - 8.7 6.8 9.1 1.6 9.2 4.9 1.9 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Syja_N PF02383.18 EFW98939.1 - 4.7e-83 279.1 0.0 6.6e-83 278.7 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Acetyltransf_7 PF13508.7 EFW98940.1 - 6.5e-07 29.7 0.5 1.7e-06 28.4 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFW98940.1 - 8.3e-06 25.8 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFW98940.1 - 0.00012 22.1 0.1 0.00021 21.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFW98940.1 - 0.00015 22.0 0.0 0.00027 21.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 EFW98940.1 - 0.007 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFW98940.1 - 0.06 13.3 0.0 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein Velvet PF11754.8 EFW98941.1 - 3.3e-55 187.7 0.1 5.4e-36 124.8 0.0 4.3 2 2 1 3 3 3 2 Velvet factor Ribosomal_60s PF00428.19 EFW98941.1 - 0.46 11.1 10.4 7.3 7.3 3.3 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein K_channel_TID PF07941.11 EFW98941.1 - 1.7 9.1 21.8 0.44 11.0 7.3 2.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain RGS PF00615.19 EFW98942.1 - 4.3e-34 117.3 0.0 9.6e-34 116.2 0.0 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 EFW98942.1 - 1.9e-19 69.5 0.0 2.2e-14 53.2 0.0 3.4 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DEAD PF00270.29 EFW98944.1 - 2.8e-44 151.0 0.0 7.8e-44 149.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.6 EFW98944.1 - 1e-20 73.7 1.2 2.2e-20 72.7 1.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 EFW98944.1 - 2.9e-20 72.7 0.0 1.4e-19 70.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW98944.1 - 0.00015 21.9 0.4 0.00036 20.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TRAP_alpha PF03896.16 EFW98944.1 - 0.11 11.7 5.9 0.18 11.0 5.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3474 PF11960.8 EFW98944.1 - 0.36 11.0 1.6 0.76 10.0 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) DUF3824 PF12868.7 EFW98944.1 - 2.8 8.6 8.0 5.7 7.6 8.0 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) BSP_II PF05432.11 EFW98944.1 - 3.3 7.3 14.3 5.1 6.7 14.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) FAD_binding_3 PF01494.19 EFW98945.1 - 3.8e-12 46.1 0.6 0.0023 17.2 0.1 3.1 3 0 0 3 3 3 3 FAD binding domain DAO PF01266.24 EFW98945.1 - 6.8e-05 22.6 0.1 0.00026 20.7 0.1 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFW98945.1 - 7.5e-05 22.9 0.2 0.00088 19.5 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW98945.1 - 0.018 14.3 0.0 0.62 9.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFW98945.1 - 0.02 14.1 0.0 0.07 12.4 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EFW98945.1 - 0.071 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 EFW98945.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EFW98945.1 - 0.14 12.7 0.0 0.42 11.2 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_28 PF02636.17 EFW98946.1 - 9.5e-77 258.2 0.0 1.2e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase SSP160 PF06933.11 EFW98946.1 - 9.3 4.3 21.6 15 3.6 21.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 UPF0183 PF03676.14 EFW98950.1 - 9.1e-47 160.2 0.0 4.2e-30 105.3 0.0 3.2 3 0 0 3 3 3 3 Uncharacterised protein family (UPF0183) Aminotran_1_2 PF00155.21 EFW98951.1 - 4.6e-63 213.6 0.0 7.4e-63 212.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II RFC1 PF08519.12 EFW98951.1 - 4.8e-59 199.0 0.1 1.6e-58 197.3 0.0 2.0 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EFW98951.1 - 2.7e-10 40.5 0.0 6.9e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EFW98951.1 - 1.6e-09 38.3 0.0 5.3e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFW98951.1 - 0.00018 21.5 0.0 0.0005 20.1 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EFW98951.1 - 0.001 19.4 0.0 0.0036 17.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFW98951.1 - 0.0017 18.8 0.3 0.037 14.4 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain DNA_pol3_delta PF06144.13 EFW98951.1 - 0.0094 15.7 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 EFW98951.1 - 0.029 14.4 0.0 0.064 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFW98951.1 - 0.051 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 EFW98951.1 - 0.058 13.3 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EFW98951.1 - 0.061 13.9 0.1 0.45 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFW98951.1 - 0.067 13.1 0.0 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 EFW98951.1 - 0.15 12.4 0.0 0.58 10.6 0.0 2.1 2 0 0 2 2 1 0 RNA helicase AAA_28 PF13521.6 EFW98951.1 - 0.84 9.9 0.0 0.84 9.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain DSPc PF00782.20 EFW98952.1 - 1.3e-25 89.7 0.0 2.5e-20 72.7 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFW98952.1 - 0.00066 19.3 0.0 0.0042 16.7 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFW98952.1 - 0.17 12.0 0.1 0.63 10.1 0.1 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate Vps51 PF08700.11 EFW98953.1 - 7.2e-14 51.6 0.0 5.1e-13 48.9 0.0 2.4 2 0 0 2 2 2 1 Vps51/Vps67 SNF2_N PF00176.23 EFW98954.1 - 7.7e-73 245.2 0.5 7.7e-73 245.2 0.5 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFW98954.1 - 1.4e-20 73.7 0.2 2.2e-18 66.6 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EFW98954.1 - 3.8e-20 71.7 0.2 9.4e-20 70.5 0.2 1.7 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 EFW98954.1 - 8.2e-16 58.1 14.8 8.2e-16 58.1 14.8 4.2 5 0 0 5 5 5 1 HSA SnAC PF14619.6 EFW98954.1 - 2.4e-14 53.7 0.1 2.4e-14 53.7 0.1 3.4 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 EFW98954.1 - 9.1e-13 47.7 4.8 9.1e-13 47.7 4.8 2.1 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 EFW98954.1 - 1.1e-09 38.5 0.0 1.1e-09 38.5 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TSA PF03249.13 EFW98954.1 - 0.89 8.3 10.0 1.6 7.4 10.0 1.3 1 0 0 1 1 1 0 Type specific antigen MT-A70 PF05063.14 EFW98955.1 - 1e-24 87.4 0.0 2.4e-24 86.2 0.0 1.6 1 1 0 1 1 1 1 MT-A70 OSCP PF00213.18 EFW98956.1 - 3.1e-42 144.6 1.6 3.6e-42 144.4 1.6 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Shufflon_N PF04917.12 EFW98956.1 - 0.085 12.3 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Shugoshin_N PF07558.11 EFW98957.1 - 6e-18 64.5 5.4 1.4e-17 63.2 5.4 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EFW98957.1 - 4e-12 45.7 7.3 2e-11 43.4 7.3 2.4 1 0 0 1 1 1 1 Shugoshin C terminus MFS_1 PF07690.16 EFW98959.1 - 3.3e-32 111.8 26.8 3.3e-32 111.8 26.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW98959.1 - 0.015 14.2 20.7 0.15 10.9 20.8 2.2 1 1 0 1 1 1 0 Sugar (and other) transporter Ribosomal_S8 PF00410.19 EFW98960.1 - 1.2e-21 77.0 0.1 1.6e-21 76.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 SGIII PF15467.6 EFW98960.1 - 0.23 10.7 0.0 0.28 10.4 0.0 1.1 1 0 0 1 1 1 0 Secretogranin-3 ADH_zinc_N PF00107.26 EFW98961.1 - 1.6e-14 54.0 0.3 5.7e-14 52.2 0.3 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFW98961.1 - 2.2e-05 24.3 0.0 0.0025 17.7 0.0 2.5 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFW98961.1 - 0.0003 21.8 0.0 0.00054 21.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFW98961.1 - 0.0038 17.1 0.0 0.0076 16.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Sas10 PF09368.10 EFW98962.1 - 4.5e-23 81.5 8.9 4.5e-23 81.5 8.9 3.0 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EFW98962.1 - 9.1e-06 26.2 0.0 9.1e-06 26.2 0.0 2.8 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Aldo_ket_red PF00248.21 EFW98963.1 - 3.7e-35 121.6 0.3 2.8e-34 118.7 0.3 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 EFW98965.1 - 1.3e-45 156.0 0.0 2.1e-45 155.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 ssDNA-exonuc_C PF10141.9 EFW98965.1 - 0.2 11.3 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain HSP20 PF00011.21 EFW98966.1 - 2.7e-16 59.6 0.1 6.6e-11 42.3 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFW98966.1 - 9.7e-06 25.1 0.0 0.022 14.3 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Sod_Fe_C PF02777.18 EFW98967.1 - 6.7e-36 122.5 0.2 1.1e-35 121.8 0.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFW98967.1 - 3.9e-30 104.2 1.2 7e-30 103.3 1.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Phycobilisome PF00502.19 EFW98968.1 - 0.015 15.2 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome protein Uso1_p115_head PF04869.14 EFW98969.1 - 1.4e-90 303.6 0.0 2.9e-90 302.6 0.0 1.6 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EFW98969.1 - 2.9e-18 66.4 33.5 2.9e-18 66.4 33.5 4.1 2 1 2 4 4 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region PrmA PF06325.13 EFW98969.1 - 1.6e-10 40.8 0.0 1.6e-10 40.8 0.0 2.6 3 1 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EFW98969.1 - 3.1e-10 40.6 0.3 1.6e-09 38.3 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW98969.1 - 1.4e-08 34.7 0.0 3.8e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW98969.1 - 3.2e-08 34.1 0.0 2e-07 31.5 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain ERM PF00769.19 EFW98969.1 - 3.6e-07 30.3 13.3 3.6e-07 30.3 13.3 2.3 1 1 1 2 2 1 1 Ezrin/radixin/moesin family Methyltransf_23 PF13489.6 EFW98969.1 - 2e-06 27.7 0.0 1e-05 25.4 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFW98969.1 - 1.4e-05 25.0 0.0 4.5e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFW98969.1 - 5.1e-05 22.9 0.8 9.6e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EFW98969.1 - 0.00045 20.9 1.9 0.0025 18.5 0.0 3.1 3 0 0 3 3 3 1 Methyltransferase domain CMAS PF02353.20 EFW98969.1 - 0.00048 19.5 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Nsp1_C PF05064.13 EFW98969.1 - 0.0027 17.5 4.8 0.0027 17.5 4.8 2.9 3 1 1 4 4 3 1 Nsp1-like C-terminal region PCMT PF01135.19 EFW98969.1 - 0.003 17.3 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 EFW98969.1 - 0.0042 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_9 PF08003.11 EFW98969.1 - 0.014 14.3 0.0 0.014 14.3 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1698) TehB PF03848.14 EFW98969.1 - 0.018 14.5 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB FtsJ PF01728.19 EFW98969.1 - 0.057 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF1319 PF07028.11 EFW98969.1 - 0.98 9.7 7.2 0.2 11.9 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) SHR-BD PF06650.12 EFW98970.1 - 3.6e-97 325.0 0.0 5.4e-94 314.6 0.1 2.6 2 0 0 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 EFW98970.1 - 2e-91 305.6 14.3 3.1e-88 295.2 0.3 5.6 6 0 0 6 6 6 4 Repeating coiled region of VPS13 VPS13 PF16908.5 EFW98970.1 - 2.2e-82 276.4 0.0 3.3e-81 272.6 0.0 3.2 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 EFW98970.1 - 3.5e-75 251.7 5.1 7.1e-71 237.6 0.3 2.7 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EFW98970.1 - 3.5e-41 139.9 0.1 1.4e-40 138.0 0.1 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EFW98970.1 - 8.4e-07 29.2 0.0 3.2e-06 27.4 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain AP4E_app_platf PF14807.6 EFW98970.1 - 0.16 12.4 0.1 1.9 8.9 0.0 2.7 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform zf-CHY PF05495.12 EFW98971.1 - 4.7e-12 46.2 17.6 9.8e-12 45.2 17.6 1.5 1 1 0 1 1 1 1 CHY zinc finger HypA PF01155.19 EFW98971.1 - 5.1 7.1 11.6 15 5.7 11.6 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Glyco_hydro_18 PF00704.28 EFW98972.1 - 1.9e-44 152.7 1.8 1.9e-44 152.7 1.8 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Hce2 PF14856.6 EFW98972.1 - 1.4e-28 99.2 2.5 7.6e-28 96.8 2.5 2.5 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.20 EFW98972.1 - 6.2e-12 45.4 0.0 7e-06 26.0 0.0 2.7 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EFW98972.1 - 5e-05 23.7 8.7 5e-05 23.7 8.7 4.3 3 1 0 3 3 3 1 Chitin recognition protein Lipase_3 PF01764.25 EFW98973.1 - 1.2e-05 25.2 0.0 3e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EFW98973.1 - 0.025 13.8 0.0 0.049 12.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFW98973.1 - 0.028 14.0 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold UPF0227 PF05728.12 EFW98973.1 - 0.066 13.2 0.1 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Ribonuclease_3 PF00636.26 EFW98974.1 - 2.8e-14 53.6 0.1 1e-13 51.8 0.0 2.0 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFW98974.1 - 3.7e-09 36.8 0.0 9.1e-09 35.6 0.0 1.6 2 0 0 2 2 2 1 Ribonuclease-III-like dsrm PF00035.26 EFW98974.1 - 0.026 15.2 0.0 0.072 13.8 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif 2OG-FeII_Oxy PF03171.20 EFW98975.1 - 9.2e-14 51.8 0.0 2.1e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFW98975.1 - 0.16 12.7 0.1 0.38 11.5 0.0 1.7 1 1 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal FAD_binding_3 PF01494.19 EFW98976.1 - 2.6e-21 76.3 0.0 3.9e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFW98976.1 - 1.8e-05 24.9 0.1 4.4e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW98976.1 - 0.00019 20.8 0.0 0.00084 18.6 0.0 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFW98976.1 - 0.0016 18.1 0.0 0.0061 16.2 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFW98976.1 - 0.0024 16.7 0.0 0.0039 16.0 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein SE PF08491.10 EFW98976.1 - 0.004 16.3 0.0 0.0087 15.1 0.0 1.5 2 0 0 2 2 2 1 Squalene epoxidase AlaDh_PNT_C PF01262.21 EFW98976.1 - 0.0063 15.8 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EFW98976.1 - 0.012 16.1 0.0 0.034 14.7 0.0 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFW98976.1 - 0.023 13.8 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFW98976.1 - 0.033 13.5 0.2 0.084 12.2 0.2 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EFW98976.1 - 0.052 13.4 0.0 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_tranf_2_3 PF13641.6 EFW98977.1 - 1e-18 68.1 0.2 1.5e-18 67.5 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFW98977.1 - 4.4e-06 26.3 0.0 8.4e-06 25.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EFW98977.1 - 0.0054 16.5 0.0 0.013 15.3 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Cupin_8 PF13621.6 EFW98978.1 - 7.1e-34 117.7 0.0 1.1e-33 117.0 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.14 EFW98978.1 - 4.4e-10 39.8 0.0 1.4e-07 31.7 0.0 2.2 1 1 1 2 2 2 2 Leucine carboxyl methyltransferase Cupin_4 PF08007.12 EFW98978.1 - 0.0069 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Kelch_4 PF13418.6 EFW98978.1 - 0.012 15.6 0.2 0.048 13.7 0.1 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF1992 PF09350.10 EFW98978.1 - 0.12 12.6 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) RNA_pol_A_bac PF01000.26 EFW98980.1 - 1.1e-31 109.5 0.0 1.7e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFW98980.1 - 3.9e-17 61.4 0.0 5.1e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF3453 PF11935.8 EFW98981.1 - 1.5e-69 234.1 0.4 4.7e-69 232.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) Allantoicase PF03561.15 EFW98982.1 - 1.4e-91 304.0 0.0 1.1e-44 151.9 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat p450 PF00067.22 EFW98984.1 - 3.2e-37 128.4 0.0 5.1e-37 127.7 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 RGS PF00615.19 EFW98985.1 - 4.7e-09 36.5 0.0 6.9e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4680 PF15730.5 EFW98985.1 - 0.026 14.8 1.8 0.026 14.8 1.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) Zn_clus PF00172.18 EFW98986.1 - 6.5e-10 39.0 10.5 1.3e-09 38.0 10.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0236 PF06782.11 EFW98986.1 - 0.26 9.9 0.4 0.45 9.1 0.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) Reprolysin_5 PF13688.6 EFW98987.1 - 1.3e-53 182.1 9.0 1.3e-53 182.1 9.0 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EFW98987.1 - 1.8e-49 168.3 3.9 4.2e-49 167.1 3.9 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EFW98987.1 - 9.2e-41 139.7 5.1 1.8e-40 138.8 4.4 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EFW98987.1 - 2.6e-10 40.9 0.1 5.8e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EFW98987.1 - 1.2e-05 26.0 26.3 1.2e-05 26.0 26.3 4.2 2 2 1 3 3 3 1 Disintegrin ADAM_CR_2 PF17771.1 EFW98987.1 - 0.00016 22.2 11.7 0.00016 22.2 11.7 3.8 2 1 0 2 2 2 1 ADAM cysteine-rich domain SKG6 PF08693.10 EFW98987.1 - 0.00089 18.6 1.7 0.002 17.5 1.7 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain LapA_dom PF06305.11 EFW98987.1 - 0.022 14.6 1.2 0.035 13.9 0.2 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Pep_M12B_propep PF01562.19 EFW98987.1 - 0.11 12.7 0.9 0.18 12.0 0.0 1.8 2 0 0 2 2 2 0 Reprolysin family propeptide MLANA PF14991.6 EFW98987.1 - 0.81 10.0 2.1 1.6 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein melan-A CTU2 PF10288.9 EFW98988.1 - 1.5e-14 54.2 3.9 2.4e-14 53.5 0.2 2.8 2 1 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 Mito_carr PF00153.27 EFW98989.1 - 4e-27 94.0 5.1 2.2e-12 46.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein PPTA PF01239.22 EFW98990.1 - 1.2e-35 120.2 8.9 1.2e-08 34.3 0.7 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Glyco_transf_22 PF03901.17 EFW98991.1 - 1.7e-45 156.0 20.5 5e-23 82.0 6.6 2.1 1 1 1 2 2 2 2 Alg9-like mannosyltransferase family Pet100 PF09803.9 EFW98991.1 - 4.5e-13 49.5 0.0 1.2e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Pet100 DUF2517 PF10725.9 EFW98991.1 - 0.18 11.6 1.9 16 5.3 0.4 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2517) ABC_membrane PF00664.23 EFW98992.1 - 1.1e-52 179.4 17.8 1.8e-39 136.1 10.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFW98992.1 - 1.3e-35 122.9 0.0 1.6e-16 61.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFW98992.1 - 1e-06 28.4 0.3 0.00024 20.6 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFW98992.1 - 0.0026 17.7 0.3 0.015 15.2 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 EFW98992.1 - 0.003 17.3 0.1 0.0046 16.7 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EFW98992.1 - 0.0031 17.4 0.1 0.038 13.8 0.1 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFW98992.1 - 0.0034 17.1 0.0 0.011 15.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFW98992.1 - 0.0075 16.7 0.0 0.045 14.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.9 EFW98992.1 - 0.039 12.7 0.3 0.097 11.4 0.1 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 EFW98992.1 - 0.054 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 EFW98992.1 - 0.07 13.4 0.0 0.64 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFW98992.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_5 PF07728.14 EFW98992.1 - 0.15 12.1 0.0 1.3 9.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EFW98992.1 - 0.15 12.3 0.2 0.71 10.2 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit XRN_M PF17846.1 EFW98993.1 - 1.7e-134 449.2 0.0 2.2e-133 445.5 0.0 2.2 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EFW98993.1 - 6.7e-67 225.4 0.0 3.5e-56 190.4 0.0 2.4 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus RasGAP PF00616.19 EFW98993.1 - 5.6e-32 111.1 0.1 8.9e-21 74.6 0.1 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EFW98993.1 - 0.0027 17.9 0.0 0.0068 16.6 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain tRNA-synt_2b PF00587.25 EFW98994.1 - 2.8e-34 118.7 0.0 4.3e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFW98994.1 - 6.4e-07 29.4 0.0 1.2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain PPR PF01535.20 EFW98995.1 - 7.2e-14 51.0 0.0 0.65 10.4 0.0 8.2 9 0 0 9 9 9 4 PPR repeat PPR_2 PF13041.6 EFW98995.1 - 4e-12 46.1 0.0 0.0081 16.3 0.0 7.1 9 0 0 9 9 9 2 PPR repeat family PPR_3 PF13812.6 EFW98995.1 - 2e-08 34.2 0.0 0.021 14.9 0.0 5.6 5 1 1 6 6 6 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFW98995.1 - 7.6e-05 22.3 0.2 0.22 11.3 0.0 4.4 4 0 0 4 4 4 1 PPR repeat PPR_long PF17177.4 EFW98995.1 - 0.0015 17.9 0.0 0.29 10.5 0.0 3.2 2 1 1 3 3 3 1 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 EFW98995.1 - 0.011 16.5 29.0 3.9 8.6 0.0 9.9 9 3 2 11 11 11 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFW98995.1 - 0.033 14.2 4.7 22 5.4 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat PG_binding_1 PF01471.18 EFW98995.1 - 0.11 12.7 0.1 0.82 9.9 0.0 2.5 2 0 0 2 2 2 0 Putative peptidoglycan binding domain TPR_10 PF13374.6 EFW98995.1 - 0.13 12.2 5.4 48 4.0 0.2 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFW98995.1 - 9.6 7.2 14.0 17 6.4 1.6 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3445 PF11927.8 EFW98997.1 - 4e-61 206.5 0.0 5e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Polyhedrin PF00738.18 EFW98997.1 - 0.2 10.9 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 Polyhedrin Peptidase_M3 PF01432.20 EFW98998.1 - 1e-24 87.7 0.1 3.2e-13 49.8 0.0 2.1 1 1 1 2 2 2 2 Peptidase family M3 PUL PF08324.11 EFW98998.1 - 0.018 14.3 0.1 0.023 13.9 0.1 1.2 1 0 0 1 1 1 0 PUL domain E1-E2_ATPase PF00122.20 EFW98999.1 - 3.7e-50 170.0 5.2 3.7e-50 170.0 5.2 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFW98999.1 - 1e-16 61.9 0.1 3.1e-16 60.3 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFW98999.1 - 1.1e-09 37.8 0.6 1e-08 34.7 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFW98999.1 - 0.0021 17.8 0.1 0.0046 16.7 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFW98999.1 - 0.063 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) DUF2818 PF10993.8 EFW98999.1 - 0.52 10.9 4.0 0.47 11.0 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2818) O-antigen_lig PF13425.6 EFW98999.1 - 3.9 6.2 11.9 0.14 10.9 5.3 1.8 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF2613 PF11021.8 EFW98999.1 - 5.5 7.2 9.2 12 6.1 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Sugar_tr PF00083.24 EFW99000.1 - 4.8e-101 338.9 18.1 5.7e-101 338.6 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFW99000.1 - 4.1e-24 85.2 36.1 5.7e-23 81.4 31.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TB2_DP1_HVA22 PF03134.19 EFW99000.1 - 5.6 7.0 7.6 0.53 10.3 2.4 2.0 2 0 0 2 2 2 0 TB2/DP1, HVA22 family Peptidase_S8 PF00082.22 EFW99001.1 - 1.7e-17 63.6 0.7 3.9e-17 62.5 0.7 1.6 1 1 0 1 1 1 1 Subtilase family Patatin PF01734.22 EFW99001.1 - 4.1e-05 23.8 0.0 0.00011 22.5 0.0 1.8 1 0 0 1 1 1 1 Patatin-like phospholipase CCDC106 PF15794.5 EFW99002.1 - 1.6 8.4 8.1 5.7 6.6 5.0 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF4834 PF16118.5 EFW99002.1 - 5.3 8.1 5.0 8.7 7.4 3.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 EFW99002.1 - 7.6 5.2 5.9 11 4.6 5.9 1.2 1 0 0 1 1 1 0 Presenilin Cu_amine_oxid PF01179.20 EFW99003.1 - 4.8e-159 529.7 0.0 5.9e-159 529.4 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EFW99003.1 - 5.7e-06 26.5 0.8 1.1e-05 25.6 0.1 1.8 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EFW99003.1 - 4.9e-05 23.7 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1640 PF07798.11 EFW99005.1 - 3.6e-42 144.4 2.5 6.6e-42 143.5 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Transferase PF02458.15 EFW99006.1 - 0.0021 16.8 0.0 0.0054 15.4 0.0 1.5 1 1 0 1 1 1 1 Transferase family FAM198 PF15051.6 EFW99006.1 - 0.029 13.2 0.0 0.057 12.3 0.0 1.4 1 0 0 1 1 1 0 FAM198 protein Mob1_phocein PF03637.17 EFW99007.1 - 5.5e-70 234.8 0.0 7e-70 234.4 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family AA_permease PF00324.21 EFW99008.1 - 1.7e-75 254.4 31.7 2.1e-75 254.2 31.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFW99008.1 - 1.1e-25 90.4 33.8 1.3e-25 90.1 33.8 1.1 1 0 0 1 1 1 1 Amino acid permease NCE101 PF11654.8 EFW99008.1 - 0.11 12.2 0.0 0.42 10.3 0.0 2.0 2 0 0 2 2 2 0 Non-classical export protein 1 DUF543 PF04418.12 EFW99009.1 - 1.8e-29 101.5 0.0 2.1e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Mus7 PF09462.10 EFW99010.1 - 5.1e-136 455.0 0.1 7.1e-136 454.6 0.1 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family zf-C2H2_4 PF13894.6 EFW99010.1 - 0.08 13.8 13.9 0.14 13.1 0.7 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFW99010.1 - 0.12 12.9 13.5 0.19 12.2 0.6 4.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EFW99010.1 - 0.15 12.1 0.7 0.37 10.8 0.7 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFW99010.1 - 0.22 11.9 2.8 1.2 9.5 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EFW99010.1 - 0.26 12.0 9.3 0.062 13.9 2.5 3.4 3 1 1 4 4 4 0 FOXP coiled-coil domain MOR2-PAG1_N PF14222.6 EFW99012.1 - 4.8e-204 679.4 0.0 9.1e-204 678.5 0.0 1.5 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EFW99012.1 - 2e-83 280.2 1.9 5.3e-82 275.5 0.0 3.3 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EFW99012.1 - 5.7e-26 90.5 11.9 1.1e-07 30.0 0.7 5.8 3 1 3 6 6 6 5 Cell morphogenesis central region Suc_Fer-like PF06999.12 EFW99012.1 - 0.76 9.6 2.9 0.58 10.0 0.1 2.1 2 0 0 2 2 2 0 Sucrase/ferredoxin-like PRC2_HTH_1 PF18118.1 EFW99012.1 - 2 9.3 3.8 1e+02 3.8 0.0 3.5 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain HTH_15 PF12324.8 EFW99012.1 - 3.3 7.7 4.7 11 6.1 0.0 4.0 5 0 0 5 5 5 0 Helix-turn-helix domain of alkylmercury lyase DUF2722 PF10846.8 EFW99013.1 - 5.2e-07 29.0 9.7 1e-06 28.0 3.4 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) NPR3 PF03666.13 EFW99013.1 - 0.19 10.5 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HET PF06985.11 EFW99014.1 - 1e-24 87.6 0.1 3.3e-24 85.9 0.1 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_C48 PF02902.19 EFW99015.1 - 3.6e-20 72.7 0.0 5.8e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain CAF-1_p150 PF11600.8 EFW99015.1 - 1.4 8.6 18.2 2.4 7.9 18.2 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Spindle_Spc25 PF08234.12 EFW99016.1 - 3.6e-24 84.8 0.0 7.3e-24 83.8 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Macoilin PF09726.9 EFW99016.1 - 0.021 13.4 7.7 0.025 13.1 7.7 1.1 1 0 0 1 1 1 0 Macoilin family HAT PF02184.16 EFW99016.1 - 0.077 13.0 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 HAT (Half-A-TPR) repeat SepSecS PF05889.13 EFW99016.1 - 0.1 11.3 0.9 0.15 10.8 0.9 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS FMN_dh PF01070.18 EFW99018.1 - 3.2e-107 358.6 0.0 3.8e-107 358.3 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EFW99018.1 - 0.00016 21.0 0.0 0.00024 20.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EFW99018.1 - 0.0009 18.3 1.4 0.017 14.2 0.5 2.3 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EFW99018.1 - 0.0021 17.5 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 EFW99018.1 - 0.14 11.4 0.2 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase DUF1180 PF06679.12 EFW99019.1 - 1.5 9.2 3.8 0.62 10.5 1.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) ILEI PF15711.5 EFW99020.1 - 0.013 16.0 0.0 0.016 15.6 0.0 1.2 1 0 0 1 1 1 0 Interleukin-like EMT inducer 2OG-FeII_Oxy_2 PF13532.6 EFW99022.1 - 6.9e-30 104.7 0.0 1e-29 104.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 EFW99022.1 - 5e-09 36.1 2.0 9.1e-09 35.3 2.0 1.4 1 0 0 1 1 1 1 GRF zinc finger SRP68 PF16969.5 EFW99023.1 - 1.7e-176 588.5 9.3 2e-176 588.3 9.3 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 DUF1040 PF06288.13 EFW99023.1 - 0.18 12.2 0.0 22 5.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1040) UbiA PF01040.18 EFW99024.1 - 1.4e-40 139.2 20.3 1.4e-40 139.2 20.3 1.4 2 0 0 2 2 2 1 UbiA prenyltransferase family Amidase PF01425.21 EFW99025.1 - 2.7e-58 198.0 0.2 6.7e-58 196.7 0.2 1.7 1 1 0 1 1 1 1 Amidase Clr5 PF14420.6 EFW99025.1 - 4.1e-20 71.7 0.3 9.4e-20 70.6 0.3 1.7 1 0 0 1 1 1 1 Clr5 domain Rad60-SLD_2 PF13881.6 EFW99025.1 - 0.16 12.1 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like EZH2_N PF18601.1 EFW99026.1 - 4.4e-33 113.5 0.9 1.3e-32 112.0 0.9 1.9 1 0 0 1 1 1 1 EZH2 N-terminal domain Ezh2_MCSS PF18600.1 EFW99026.1 - 9.9e-24 82.7 3.5 2e-23 81.8 3.5 1.5 1 0 0 1 1 1 1 MCSS domain SET PF00856.28 EFW99026.1 - 5.9e-14 52.8 0.1 5.9e-14 52.8 0.1 4.2 4 2 0 4 4 4 1 SET domain preSET_CXC PF18264.1 EFW99026.1 - 0.00038 20.9 12.5 0.00038 20.9 12.5 3.7 3 1 1 4 4 4 1 CXC domain AJAP1_PANP_C PF15298.6 EFW99026.1 - 2.5 8.3 15.1 5.4 7.2 0.7 2.7 2 0 0 2 2 2 0 AJAP1/PANP C-terminus IKI3 PF04762.12 EFW99027.1 - 4.6e-270 898.6 0.0 8.6e-270 897.7 0.0 1.4 2 0 0 2 2 2 1 IKI3 family ANAPC4_WD40 PF12894.7 EFW99027.1 - 0.009 16.3 1.1 64 3.9 0.0 4.4 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_60s PF00428.19 EFW99027.1 - 7.3 7.3 7.6 58 4.4 0.2 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Ccdc124 PF06244.12 EFW99028.1 - 5.1e-30 104.7 18.3 7.5e-29 100.9 18.3 2.1 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 SET PF00856.28 EFW99029.1 - 1.7e-07 31.8 0.0 2.9e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 SET domain Phosphodiest PF01663.22 EFW99030.1 - 1e-11 45.0 0.3 4.1e-11 43.1 0.2 1.8 1 1 1 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFW99030.1 - 2.6e-05 23.8 0.0 6.6e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EFW99030.1 - 0.0026 17.1 0.1 0.0026 17.1 0.1 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily PglZ PF08665.12 EFW99030.1 - 0.0097 16.0 0.2 2.4 8.2 0.0 2.4 2 0 0 2 2 2 2 PglZ domain adh_short PF00106.25 EFW99031.1 - 3.5e-30 104.9 0.0 4.6e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW99031.1 - 1.8e-19 70.3 0.0 2.2e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW99031.1 - 9.2e-09 35.5 0.2 3.3e-08 33.7 0.2 1.8 1 1 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EFW99031.1 - 0.0012 18.9 0.1 0.0022 18.0 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EFW99031.1 - 0.0014 18.5 0.7 0.0072 16.2 0.3 2.2 2 0 0 2 2 2 1 NAD(P)H-binding CoA_binding_2 PF13380.6 EFW99031.1 - 0.0023 18.4 0.2 0.006 17.1 0.2 1.7 1 0 0 1 1 1 1 CoA binding domain THF_DHG_CYH_C PF02882.19 EFW99031.1 - 0.0037 16.6 1.5 0.23 10.8 0.1 2.2 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain F420_oxidored PF03807.17 EFW99031.1 - 0.0064 17.0 0.0 0.087 13.4 0.2 2.3 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 EFW99031.1 - 0.035 13.6 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 EFW99031.1 - 0.085 13.3 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding DFP PF04127.15 EFW99031.1 - 0.28 11.0 1.0 0.49 10.2 1.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein ECH_1 PF00378.20 EFW99032.1 - 2e-24 86.3 0.0 2.5e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFW99032.1 - 6.3e-15 55.5 0.0 6.7e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Npa1 PF11707.8 EFW99033.1 - 9.2e-102 340.9 0.0 1.5e-101 340.2 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EFW99033.1 - 4e-60 202.9 0.2 1.2e-59 201.3 0.2 1.8 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 Creb_binding PF09030.10 EFW99033.1 - 0.18 12.5 0.0 3.1 8.5 0.0 2.9 3 0 0 3 3 3 0 Creb binding Glycos_transf_1 PF00534.20 EFW99034.1 - 2.1e-20 73.0 0.0 4.1e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFW99034.1 - 5.4e-13 49.5 0.0 9e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF4031 PF13223.6 EFW99034.1 - 0.0094 16.2 0.1 1.8 8.9 0.0 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF4031) Glyco_trans_1_2 PF13524.6 EFW99034.1 - 0.07 13.5 0.0 0.25 11.8 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferases group 1 Peptidase_M3 PF01432.20 EFW99035.1 - 5.9e-100 335.7 0.0 8e-100 335.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 NEL PF14496.6 EFW99035.1 - 0.014 14.8 0.1 1.1 8.7 0.0 2.8 3 0 0 3 3 3 0 C-terminal novel E3 ligase, LRR-interacting Mito_carr PF00153.27 EFW99036.1 - 1.8e-61 204.1 2.6 3.3e-23 81.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 EFW99036.1 - 5.6e-21 72.5 3.1 2.1e-06 26.9 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 EFW99036.1 - 2.5e-19 67.8 3.4 1.5e-06 27.5 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFW99036.1 - 2e-18 66.6 3.4 2.2e-11 44.1 0.3 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFW99036.1 - 5.3e-15 54.0 4.5 0.0003 20.5 0.5 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EFW99036.1 - 1.1e-12 47.5 8.0 0.00015 21.5 0.3 3.6 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFW99036.1 - 6.4e-07 29.7 0.0 0.0045 17.3 0.0 2.5 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFW99036.1 - 0.0043 17.0 0.3 0.05 13.6 0.1 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Serine_protease PF18405.1 EFW99036.1 - 0.12 11.5 0.5 3.8 6.6 0.0 2.9 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Fungal_trans PF04082.18 EFW99037.1 - 2.7e-09 36.5 0.0 4.1e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFW99037.1 - 8.1e-07 29.1 9.3 1.5e-06 28.2 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3138 PF11336.8 EFW99037.1 - 0.97 8.0 8.2 2.8 6.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) HATPase_c PF02518.26 EFW99038.1 - 1.2e-29 103.1 0.0 2.4e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFW99038.1 - 1.3e-22 80.1 0.1 2.8e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFW99038.1 - 1.7e-18 66.4 0.9 9.5e-18 64.0 0.9 2.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.6 EFW99038.1 - 2.9e-12 47.3 0.8 3e-11 44.0 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain GAF_2 PF13185.6 EFW99038.1 - 6.5e-12 45.9 0.0 2.6e-11 44.0 0.0 2.1 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.25 EFW99038.1 - 1.7e-06 27.6 0.0 3.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain GAF PF01590.26 EFW99038.1 - 2.1e-06 28.4 0.1 8.8e-06 26.4 0.1 2.2 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EFW99038.1 - 0.00069 19.5 0.0 0.0017 18.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pkinase_Tyr PF07714.17 EFW99038.1 - 0.0019 17.5 0.0 0.0049 16.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase MeaB PF03308.16 EFW99038.1 - 0.0072 15.3 0.0 0.042 12.8 0.1 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EFW99038.1 - 0.0088 16.0 0.2 0.28 11.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EFW99038.1 - 0.047 14.0 1.6 0.46 10.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain TPR_19 PF14559.6 EFW99038.1 - 0.082 13.4 2.8 0.19 12.2 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFW99038.1 - 0.13 12.4 6.9 40 4.7 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFW99038.1 - 0.43 10.9 11.0 0.2 12.0 1.3 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 EFW99039.1 - 2.7e-11 43.3 0.0 8.2e-08 31.9 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99039.1 - 5e-05 22.7 0.0 0.00014 21.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase ATG11 PF10377.9 EFW99040.1 - 7.6e-46 155.4 1.9 1.2e-44 151.5 0.0 3.1 2 0 0 2 2 2 1 Autophagy-related protein 11 Transposase_24 PF03004.14 EFW99040.1 - 0.0014 18.7 10.6 0.0039 17.3 4.7 3.3 2 1 0 2 2 2 1 Plant transposase (Ptta/En/Spm family) FERM_f0 PF16511.5 EFW99040.1 - 0.043 14.1 0.1 4.9 7.5 0.0 2.5 2 0 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM Golgin_A5 PF09787.9 EFW99040.1 - 1.1 8.7 66.7 0.57 9.6 15.3 4.8 3 1 2 5 5 5 0 Golgin subfamily A member 5 ApoO PF09769.9 EFW99040.1 - 2.9 7.9 5.0 1.5 8.8 0.1 3.3 2 1 1 3 3 3 0 Apolipoprotein O Fungal_trans_2 PF11951.8 EFW99042.1 - 6.5e-14 51.5 0.9 2.5e-13 49.6 0.2 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFW99042.1 - 1.5e-06 28.2 12.6 2.4e-06 27.5 12.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vps39_2 PF10367.9 EFW99042.1 - 0.74 10.3 3.4 1.9 9.0 3.0 1.8 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 Myb_DNA-binding PF00249.31 EFW99043.1 - 7.6e-13 48.4 4.4 5.8e-10 39.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFW99043.1 - 5e-05 23.5 3.1 0.0083 16.4 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain PAP_central PF04928.17 EFW99044.1 - 1.2e-106 355.2 0.0 1.5e-106 354.9 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EFW99044.1 - 4.4e-61 205.4 0.0 7.1e-61 204.8 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EFW99044.1 - 1.2e-09 38.3 0.0 2.9e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EFW99044.1 - 0.024 14.4 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 EFW99044.1 - 0.053 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Aa_trans PF01490.18 EFW99045.1 - 1.4e-71 241.4 25.2 1.8e-71 241.0 25.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Asp PF00026.23 EFW99045.1 - 5.2e-55 187.1 9.3 7.7e-55 186.5 9.3 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFW99045.1 - 2.8e-07 31.0 3.3 1.2e-05 25.7 3.3 2.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal MFS_1 PF07690.16 EFW99046.1 - 5.6e-37 127.5 14.3 5.6e-37 127.5 14.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW99046.1 - 2.7e-08 33.1 3.5 2.7e-08 33.1 3.5 1.9 2 1 0 3 3 3 1 Sugar (and other) transporter Nuc_H_symport PF03825.16 EFW99046.1 - 0.0029 16.6 1.4 0.0089 15.1 1.4 1.8 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1_like PF12832.7 EFW99046.1 - 0.0096 14.8 12.6 0.0082 15.0 5.4 3.1 2 2 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 EFW99046.1 - 0.013 13.9 0.9 0.02 13.4 0.9 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EFW99046.1 - 1.1 7.6 9.0 2.1 6.6 4.2 2.4 2 1 0 2 2 2 0 Transmembrane secretion effector Thymidylat_synt PF00303.19 EFW99047.1 - 1.7e-106 355.3 0.0 1.9e-106 355.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase VPS9 PF02204.18 EFW99049.1 - 6.7e-23 80.9 0.0 1.2e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain APC_u14 PF16635.5 EFW99049.1 - 0.23 12.0 3.5 0.68 10.5 3.5 1.8 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr CNH PF00780.22 EFW99050.1 - 1e-75 254.9 0.0 3e-75 253.4 0.0 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 EFW99050.1 - 2.4e-43 147.5 0.0 4.3e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EFW99050.1 - 4.6e-33 115.0 0.0 8.7e-33 114.1 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EFW99050.1 - 8.3e-15 54.6 0.0 1.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Coiled-coil_56 PF09813.9 EFW99052.1 - 4.3e-05 23.5 0.2 6.1e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 56 Ribosomal_L16 PF00252.18 EFW99053.1 - 2.5e-31 108.4 0.3 3.5e-31 108.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Aminotran_5 PF00266.19 EFW99054.1 - 1.1e-23 83.8 0.0 1.6e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Transferase PF02458.15 EFW99055.1 - 2.6e-25 89.0 0.0 1.5e-23 83.1 0.0 2.9 1 1 0 1 1 1 1 Transferase family DEAD PF00270.29 EFW99056.1 - 4.5e-44 150.3 0.1 9e-44 149.3 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW99056.1 - 1.6e-19 70.2 0.0 5.9e-19 68.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99056.1 - 0.00022 21.2 0.0 0.00038 20.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFW99056.1 - 0.0012 18.1 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 EFW99056.1 - 0.098 12.4 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFW99056.1 - 0.16 12.2 0.6 0.76 10.0 0.6 2.2 1 1 0 1 1 1 0 AAA domain adh_short PF00106.25 EFW99057.1 - 8.1e-40 136.4 0.0 1e-39 136.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW99057.1 - 8e-31 107.4 0.0 1e-30 107.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW99057.1 - 8.5e-12 45.3 0.1 1.1e-11 44.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EFW99057.1 - 0.0087 15.8 0.3 0.021 14.6 0.2 1.6 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF771 PF05595.11 EFW99057.1 - 0.022 14.7 0.1 0.42 10.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF771) Polysacc_synt_2 PF02719.15 EFW99057.1 - 0.024 13.8 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 EFW99057.1 - 0.027 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DNA_pol3_delta2 PF13177.6 EFW99058.1 - 3.1e-10 40.1 0.0 5.6e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EFW99058.1 - 4.3e-06 27.0 0.1 4.9e-05 23.6 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EFW99058.1 - 1.1e-05 25.8 0.1 2.4e-05 24.8 0.1 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFW99058.1 - 6.1e-05 23.5 0.8 0.0015 18.9 0.4 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EFW99058.1 - 0.00052 19.8 0.3 0.0013 18.5 0.3 1.5 1 1 0 1 1 1 1 AAA domain Rep_fac_C PF08542.11 EFW99058.1 - 0.0015 18.9 0.0 0.0043 17.4 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 EFW99058.1 - 0.0058 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain Resolvase PF00239.21 EFW99058.1 - 0.0063 16.6 0.1 1.5 8.9 0.1 2.6 3 0 0 3 3 2 1 Resolvase, N terminal domain ABC_tran PF00005.27 EFW99058.1 - 0.024 15.2 0.0 0.047 14.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EFW99058.1 - 0.026 14.7 0.2 0.075 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain T4SS-DNA_transf PF02534.14 EFW99058.1 - 0.027 13.3 0.1 0.11 11.2 0.0 1.8 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer ResIII PF04851.15 EFW99058.1 - 0.12 12.4 0.2 0.31 11.0 0.2 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 EFW99058.1 - 0.21 11.6 0.7 0.88 9.6 0.7 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) zf-C3HC4 PF00097.25 EFW99059.1 - 1.8e-07 30.9 4.9 1.8e-07 30.9 4.9 4.8 6 0 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFW99059.1 - 2.8e-06 27.1 4.3 2.8e-06 27.1 4.3 4.8 7 2 1 8 8 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFW99059.1 - 4.2e-06 26.7 4.5 4.2e-06 26.7 4.5 3.6 4 0 0 4 4 2 1 RING-type zinc-finger zf-RING_6 PF14835.6 EFW99059.1 - 4.3e-06 26.5 0.4 4.3e-06 26.5 0.4 2.6 3 0 0 3 3 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EFW99059.1 - 2.5e-05 24.5 5.3 2.5e-05 24.5 5.3 4.8 4 2 0 4 4 2 1 Ring finger domain zf-RING_5 PF14634.6 EFW99059.1 - 0.00015 21.6 4.2 0.00015 21.6 4.2 4.7 5 1 0 5 5 3 1 zinc-RING finger domain SH3_1 PF00018.28 EFW99059.1 - 0.00039 20.0 0.0 0.00077 19.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain zf-C3HC4_4 PF15227.6 EFW99059.1 - 0.00039 20.5 4.4 0.00039 20.5 4.4 3.5 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING SH3_9 PF14604.6 EFW99059.1 - 0.00052 19.8 0.1 0.00052 19.8 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EFW99059.1 - 0.079 12.6 0.2 0.18 11.5 0.2 1.6 1 0 0 1 1 1 0 Variant SH3 domain zf-SNAP50_C PF12251.8 EFW99059.1 - 8.4 6.0 10.9 0.61 9.7 1.8 2.9 2 1 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal Ribosomal_L9_N PF01281.19 EFW99060.1 - 9.1e-11 41.2 0.0 2e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 EFW99060.1 - 0.0047 17.4 0.0 0.054 14.0 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L9, C-terminal domain BCDHK_Adom3 PF10436.9 EFW99061.1 - 3.2e-75 251.4 0.0 4.6e-75 250.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFW99061.1 - 1.3e-12 48.2 0.0 2.8e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFW99061.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aminotran_3 PF00202.21 EFW99062.1 - 9.5e-53 179.3 0.0 1.8e-52 178.4 0.0 1.3 2 0 0 2 2 2 1 Aminotransferase class-III OST3_OST6 PF04756.13 EFW99063.1 - 2.7e-108 361.8 0.0 3.9e-108 361.2 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Acyl_transf_1 PF00698.21 EFW99063.1 - 2.4e-17 63.4 0.2 4.1e-14 52.8 0.3 2.3 2 0 0 2 2 2 2 Acyl transferase domain zf-RING_UBOX PF13445.6 EFW99063.1 - 3.8e-09 36.4 5.2 1.4e-05 25.0 0.7 2.7 2 0 0 2 2 2 2 RING-type zinc-finger zf-NOSIP PF15906.5 EFW99063.1 - 4.5e-08 33.1 0.0 8.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_2 PF13923.6 EFW99063.1 - 1.4e-07 31.2 9.5 0.00042 20.1 2.4 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFW99063.1 - 7.1e-07 29.5 7.5 0.00042 20.6 2.0 3.0 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.25 EFW99063.1 - 1.9e-05 24.4 7.6 0.0017 18.2 1.3 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EFW99063.1 - 4.5e-05 23.5 3.1 0.0004 20.5 1.1 2.7 2 0 0 2 2 2 1 FYVE zinc finger Rtf2 PF04641.12 EFW99063.1 - 0.00026 20.5 2.3 0.028 13.8 1.4 2.7 2 1 0 2 2 2 1 Rtf2 RING-finger zf-RING_5 PF14634.6 EFW99063.1 - 0.00037 20.4 2.6 0.00037 20.4 2.6 3.1 2 2 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFW99063.1 - 0.00099 18.9 17.6 0.0019 18.0 1.7 3.1 4 0 0 4 4 3 2 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 EFW99063.1 - 0.013 15.3 0.6 1.1 9.2 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_4 PF15227.6 EFW99063.1 - 0.015 15.5 12.3 0.58 10.4 1.1 3.3 3 1 0 3 3 2 0 zinc finger of C3HC4-type, RING Thioredoxin PF00085.20 EFW99063.1 - 0.06 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin Prok-RING_4 PF14447.6 EFW99063.1 - 0.1 12.5 15.9 0.65 9.9 6.9 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.5 EFW99063.1 - 0.17 11.8 2.0 0.45 10.4 2.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HXXEE PF13787.6 EFW99063.1 - 0.76 10.6 5.4 0.17 12.7 0.4 2.4 3 0 0 3 3 2 0 Protein of unknown function with HXXEE motif zf-RING_4 PF14570.6 EFW99063.1 - 1.6 8.5 6.1 0.15 11.8 0.1 2.4 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain IBR PF01485.21 EFW99063.1 - 2.4 8.4 4.8 1.5 9.1 0.3 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zinc-ribbons_6 PF07191.12 EFW99063.1 - 5.8 7.0 11.7 1.8 8.6 1.0 3.2 3 0 0 3 3 3 0 zinc-ribbons NDUF_B12 PF08122.12 EFW99064.1 - 6.6e-26 90.1 2.4 9.1e-26 89.7 2.4 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Zn_clus PF00172.18 EFW99065.1 - 1e-07 31.9 13.5 2.2e-07 30.9 13.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5375 PF17345.2 EFW99065.1 - 0.095 12.6 0.1 0.47 10.4 0.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5375) PXA PF02194.15 EFW99066.1 - 2.7e-29 102.4 0.1 6.5e-29 101.2 0.1 1.7 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EFW99066.1 - 1.7e-19 70.4 1.2 4.2e-19 69.2 0.0 2.4 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 EFW99066.1 - 0.00046 20.1 0.0 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 PX domain 2HCT PF03390.15 EFW99066.1 - 0.12 10.9 0.2 0.22 10.1 0.2 1.3 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family Phage_holin_8 PF16931.5 EFW99066.1 - 1.9 8.4 7.7 0.047 13.7 0.6 2.1 2 0 0 2 2 2 0 Putative phage holin UNC-93 PF05978.16 EFW99067.1 - 4.1e-06 26.6 7.7 9.3e-06 25.4 7.7 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EFW99067.1 - 1.7e-05 23.9 31.0 1.7e-05 23.9 31.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily EMP24_GP25L PF01105.24 EFW99068.1 - 4.6e-52 176.6 0.0 5.2e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GspH PF12019.8 EFW99068.1 - 0.087 13.2 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 Type II transport protein GspH SecE PF00584.20 EFW99069.1 - 3.4e-13 49.3 0.1 3.9e-13 49.1 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Kei1 PF08552.11 EFW99071.1 - 1.1e-47 162.4 10.7 4.2e-47 160.5 10.7 1.9 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 SPC12 PF06645.13 EFW99071.1 - 0.0063 16.6 3.0 0.0063 16.6 3.0 2.9 2 1 0 2 2 2 1 Microsomal signal peptidase 12 kDa subunit (SPC12) SH3_9 PF14604.6 EFW99072.1 - 2.5e-13 49.6 0.0 5.3e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 EFW99072.1 - 7.7e-13 48.4 0.0 1.3e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 EFW99072.1 - 7.2e-12 44.7 0.0 1.5e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 EFW99072.1 - 9.5e-09 35.7 0.0 6.2e-08 33.1 0.0 2.2 1 1 0 1 1 1 1 PH domain SH3_2 PF07653.17 EFW99072.1 - 0.0019 17.8 0.0 0.004 16.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EFW99072.1 - 0.0051 17.2 0.0 0.0092 16.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.6 EFW99072.1 - 0.0071 16.8 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Glyco_hydro_61 PF03443.14 EFW99073.1 - 0.00056 19.9 1.3 0.001 19.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 RIFIN PF02009.16 EFW99073.1 - 3.1 7.6 4.0 4.1 7.2 4.0 1.2 1 0 0 1 1 1 0 Rifin NAD_binding_4 PF07993.12 EFW99074.1 - 1.1e-39 136.2 0.0 1.8e-39 135.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EFW99074.1 - 4.1e-34 117.9 0.0 7.3e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Fungal_trans PF04082.18 EFW99074.1 - 7.3e-28 97.3 0.0 1.4e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Epimerase PF01370.21 EFW99074.1 - 1.3e-13 51.0 0.0 2.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EFW99074.1 - 1.1e-07 32.1 0.2 5.8e-06 26.6 0.1 2.9 2 0 0 2 2 2 1 Phosphopantetheine attachment site Zn_clus PF00172.18 EFW99074.1 - 1.7e-07 31.3 10.8 1.7e-07 31.3 10.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KR PF08659.10 EFW99074.1 - 6.9e-05 22.8 0.0 0.00016 21.7 0.0 1.6 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFW99074.1 - 0.006 16.0 0.0 0.026 13.9 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFW99074.1 - 0.035 13.1 0.0 0.19 10.7 0.0 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EFW99074.1 - 0.044 13.3 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Rib_5-P_isom_A PF06026.14 EFW99075.1 - 1.7e-49 167.7 0.0 3e-49 166.9 0.0 1.4 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Peptidase_C92 PF05708.12 EFW99075.1 - 0.073 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family ABC_membrane PF00664.23 EFW99076.1 - 6.1e-101 337.7 32.9 1.3e-51 175.9 9.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFW99076.1 - 8.3e-68 227.2 0.0 7.7e-33 113.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFW99076.1 - 1.4e-12 47.5 0.0 0.00069 19.1 0.0 3.9 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFW99076.1 - 2.7e-07 30.2 1.6 0.0029 17.3 0.1 3.4 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFW99076.1 - 3e-05 24.0 0.1 0.2 11.5 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase ABC_ATPase PF09818.9 EFW99076.1 - 8.1e-05 21.6 3.9 0.094 11.5 0.1 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 EFW99076.1 - 9.7e-05 22.8 7.0 0.047 14.1 0.2 3.5 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFW99076.1 - 0.00014 22.1 0.8 0.64 10.3 0.0 3.5 3 1 0 3 3 3 2 AAA domain AAA_25 PF13481.6 EFW99076.1 - 0.00051 19.7 0.0 0.36 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EFW99076.1 - 0.00068 19.4 0.0 0.49 10.1 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 EFW99076.1 - 0.00074 20.0 2.7 4 7.9 0.1 4.1 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFW99076.1 - 0.0044 17.3 0.2 0.67 10.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EFW99076.1 - 0.0051 16.9 0.3 4.3 7.3 0.1 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain SbcCD_C PF13558.6 EFW99076.1 - 0.0068 16.6 2.3 3.6 7.9 0.2 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 EFW99076.1 - 0.0071 16.2 1.3 7.8 6.2 0.0 3.5 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EFW99076.1 - 0.008 16.2 0.1 7.5 6.6 0.0 3.2 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 EFW99076.1 - 0.011 14.9 0.0 4.4 6.4 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Zeta_toxin PF06414.12 EFW99076.1 - 0.012 14.9 0.4 6.4 6.0 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin AAA_33 PF13671.6 EFW99076.1 - 0.013 15.6 0.0 9.5 6.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFW99076.1 - 0.03 14.9 0.0 14 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFW99076.1 - 0.035 13.8 8.3 1.2 8.9 0.3 3.8 3 1 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EFW99076.1 - 0.047 13.2 0.1 7 6.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 EFW99076.1 - 0.062 12.4 0.0 12 5.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 EFW99076.1 - 0.067 13.7 0.1 4.4 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFW99076.1 - 0.071 13.0 0.1 1.9 8.4 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF4154 PF13689.6 EFW99076.1 - 0.071 13.3 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 YfiR/HmsC-like SRP54 PF00448.22 EFW99076.1 - 0.074 12.7 0.2 3.9 7.1 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Rad17 PF03215.15 EFW99076.1 - 0.1 12.5 0.0 0.64 9.9 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain Bacteriocin_IIc PF10439.9 EFW99076.1 - 5.9 7.1 15.6 2.8 8.1 0.2 4.2 4 0 0 4 4 3 0 Bacteriocin class II with double-glycine leader peptide zf-C2H2 PF00096.26 EFW99077.1 - 5.2e-07 29.8 22.0 0.00014 22.1 1.7 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFW99077.1 - 4.3e-05 23.7 2.0 4.3e-05 23.7 2.0 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFW99077.1 - 0.0018 18.9 18.1 0.022 15.6 1.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EFW99077.1 - 0.0071 16.7 2.2 0.042 14.3 0.7 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EFW99077.1 - 0.018 15.1 0.4 0.018 15.1 0.4 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFW99077.1 - 0.13 12.6 0.1 0.13 12.6 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 EFW99077.1 - 0.26 11.2 5.8 0.25 11.3 0.9 2.5 1 1 1 2 2 2 0 SprT-like zinc ribbon domain VIR_N PF15912.5 EFW99077.1 - 4.6 6.8 14.0 9.2 5.8 14.0 1.5 1 1 0 1 1 1 0 Virilizer, N-terminal ADIP PF11559.8 EFW99078.1 - 5.1e-41 140.3 1.9 5.1e-41 140.3 1.9 2.7 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding F-box PF00646.33 EFW99078.1 - 1.1e-06 28.3 1.7 2.3e-06 27.3 0.3 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFW99078.1 - 0.00019 21.3 0.6 0.00049 19.9 0.6 1.7 1 0 0 1 1 1 1 F-box-like TPR_14 PF13428.6 EFW99078.1 - 0.00079 20.0 2.4 0.00079 20.0 2.4 4.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFW99078.1 - 0.015 15.6 0.2 0.015 15.6 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 EFW99078.1 - 0.4 11.1 39.9 0.13 12.6 10.0 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain DASH_Hsk3 PF08227.11 EFW99079.1 - 2.9e-16 59.5 5.8 5.2e-16 58.7 5.8 1.4 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like GIT_SHD PF08518.11 EFW99081.1 - 3e-25 87.5 5.6 1.8e-13 49.8 2.0 2.5 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT THP2 PF09432.10 EFW99081.1 - 0.018 15.1 1.0 0.018 15.1 1.0 2.7 2 1 1 3 3 3 0 Tho complex subunit THP2 Filament PF00038.21 EFW99081.1 - 0.023 14.3 32.2 0.059 13.0 5.2 2.4 2 0 0 2 2 2 0 Intermediate filament protein SlyX PF04102.12 EFW99081.1 - 0.031 14.9 33.8 0.6 10.8 0.1 5.4 3 1 1 4 4 4 0 SlyX Fez1 PF06818.15 EFW99081.1 - 0.043 14.3 29.8 0.36 11.3 3.1 2.6 2 0 0 2 2 2 0 Fez1 FUSC PF04632.12 EFW99081.1 - 0.59 8.6 20.7 0.43 9.1 18.7 1.8 2 0 0 2 2 2 0 Fusaric acid resistance protein family UPF0242 PF06785.11 EFW99081.1 - 0.63 10.1 35.6 0.74 9.9 20.5 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 EFW99081.1 - 3.6 7.7 48.3 5.8 7.0 27.4 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ATPase PF06745.13 EFW99081.1 - 4.3 6.6 6.5 11 5.3 6.5 1.6 1 0 0 1 1 1 0 KaiC AIM5 PF17050.5 EFW99082.1 - 2.3e-20 73.2 0.5 8e-20 71.4 0.5 2.0 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 VCH_CASS14 PF18315.1 EFW99082.1 - 0.23 11.5 4.7 0.11 12.5 0.7 2.1 1 1 1 2 2 2 0 Integron cassette protein VCH_CASS1 chain MccV PF17508.2 EFW99082.1 - 1.1 9.9 5.3 1.8 9.2 4.7 1.7 1 1 0 1 1 1 0 Microcin V bacteriocin Pkinase PF00069.25 EFW99083.1 - 6.3e-65 219.2 0.2 7.4e-65 218.9 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99083.1 - 5.5e-18 65.2 0.0 7.4e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFW99083.1 - 3.4e-06 27.2 0.0 0.00013 22.0 0.2 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFW99083.1 - 0.00032 19.6 0.0 0.00057 18.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFW99083.1 - 0.008 15.6 0.3 0.017 14.5 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFW99083.1 - 0.013 14.9 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pantoate_ligase PF02569.15 EFW99084.1 - 1.5e-93 312.9 0.0 1.7e-93 312.7 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase ATP-sulfurylase PF01747.17 EFW99084.1 - 0.023 14.2 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 ATP-sulfurylase DUF4079 PF13301.6 EFW99085.1 - 0.042 14.0 13.5 0.13 12.4 2.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 EFW99085.1 - 4.1 7.3 7.3 7.2 6.5 6.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) CsbD PF05532.12 EFW99086.1 - 2.5e-21 75.3 17.6 2e-11 43.6 1.5 3.1 2 1 1 3 3 3 3 CsbD-like Peptidase_A4 PF01828.17 EFW99087.1 - 2.1e-77 259.3 10.2 2.6e-77 259.0 10.2 1.1 1 0 0 1 1 1 1 Peptidase A4 family Kdo PF06293.14 EFW99088.1 - 0.00045 19.6 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HSDR_N_2 PF13588.6 EFW99088.1 - 0.0014 18.6 0.1 0.93 9.5 0.0 2.4 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase PF00069.25 EFW99088.1 - 0.0036 16.7 0.0 0.0065 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Spore_YhaL PF14147.6 EFW99088.1 - 0.36 10.5 1.1 1.1 9.0 1.1 1.8 1 0 0 1 1 1 0 Sporulation protein YhaL ThiF PF00899.21 EFW99089.1 - 1.6e-22 80.1 0.0 1.2e-13 51.0 0.4 2.1 1 1 1 2 2 2 2 ThiF family Pkinase PF00069.25 EFW99090.1 - 4.1e-27 95.2 0.0 5.6e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99090.1 - 2.1e-14 53.4 0.0 2.8e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFW99090.1 - 1.1e-06 27.7 0.1 1.5e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pyrid_oxidase_2 PF13883.6 EFW99091.1 - 2.6e-45 154.4 0.0 3.2e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase UQ_con PF00179.26 EFW99092.1 - 5.7e-50 168.6 0.0 7.1e-50 168.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFW99092.1 - 6e-07 29.2 0.0 7.8e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFW99092.1 - 0.0007 19.9 0.0 0.0008 19.7 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EFW99092.1 - 0.0044 16.9 0.0 0.0061 16.4 0.0 1.4 1 0 0 1 1 1 1 UEV domain L51_S25_CI-B8 PF05047.16 EFW99093.1 - 4.9e-11 42.4 0.0 6.2e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CH PF00307.31 EFW99094.1 - 1.4e-71 237.6 0.0 4.2e-20 72.0 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EFW99094.1 - 9.2e-07 29.2 0.5 4.4e-05 23.8 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EFW99094.1 - 0.0001 21.6 0.9 1 9.1 0.3 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EFW99094.1 - 0.012 15.5 0.6 1.2 9.3 0.1 3.3 2 0 0 2 2 2 0 EF-hand domain CH_2 PF06294.11 EFW99094.1 - 0.077 13.1 0.8 25 5.1 0.1 3.4 3 0 0 3 3 3 0 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFW99094.1 - 0.098 12.5 0.0 20 5.1 0.0 3.2 3 0 0 3 3 3 0 CAMSAP CH domain Aldedh PF00171.22 EFW99095.1 - 7.1e-133 443.5 0.0 8.4e-133 443.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFW99095.1 - 0.0027 16.8 0.2 0.0061 15.6 0.2 1.7 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Malate_synthase PF01274.22 EFW99097.1 - 1e-230 766.5 0.0 1.2e-230 766.3 0.0 1.0 1 0 0 1 1 1 1 Malate synthase PQ-loop PF04193.14 EFW99098.1 - 3.7e-25 87.5 2.5 1e-13 50.8 0.2 2.4 2 0 0 2 2 2 2 PQ loop repeat eIF-6 PF01912.18 EFW99099.1 - 3.5e-77 258.3 0.7 5.3e-77 257.7 0.7 1.2 1 0 0 1 1 1 1 eIF-6 family Mpp10 PF04006.12 EFW99099.1 - 0.53 8.7 6.1 0.72 8.2 6.1 1.1 1 0 0 1 1 1 0 Mpp10 protein SDA1 PF05285.12 EFW99099.1 - 6 6.2 8.3 9.3 5.6 8.3 1.2 1 0 0 1 1 1 0 SDA1 Pkinase PF00069.25 EFW99101.1 - 2.4e-67 227.1 0.3 1.6e-66 224.4 0.3 2.1 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 EFW99101.1 - 2.4e-40 136.9 0.6 2.4e-40 136.9 0.6 2.2 3 0 0 3 3 3 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 EFW99101.1 - 7.5e-38 130.3 0.2 2.6e-35 121.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFW99101.1 - 1.2e-07 31.3 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFW99101.1 - 0.00036 19.6 0.0 0.00072 18.6 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFW99101.1 - 0.0019 17.8 0.1 0.0046 16.6 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EFW99101.1 - 0.007 15.8 2.8 0.013 14.9 0.0 2.5 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFW99101.1 - 0.01 15.8 0.1 0.036 14.0 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFW99101.1 - 1.5 8.4 7.7 0.039 13.5 0.4 2.1 3 0 0 3 3 3 0 Choline/ethanolamine kinase Zn_clus PF00172.18 EFW99102.1 - 1.1e-07 31.8 9.2 1.9e-07 31.1 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFW99102.1 - 1.9e-05 23.8 0.0 3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Metallophos PF00149.28 EFW99103.1 - 1.2e-12 48.8 1.2 2.1e-12 48.0 1.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EFW99103.1 - 0.068 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain OPT PF03169.15 EFW99104.1 - 3.7e-186 620.4 53.7 4.3e-186 620.2 53.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DnaJ PF00226.31 EFW99105.1 - 6.4e-05 23.0 0.0 0.00013 22.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DUF3395 PF11875.8 EFW99105.1 - 0.00038 20.4 0.0 0.00038 20.4 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) Sigma70_ner PF04546.13 EFW99105.1 - 0.01 15.7 20.3 0.092 12.6 2.9 3.2 3 0 0 3 3 3 0 Sigma-70, non-essential region eIF-3c_N PF05470.12 EFW99105.1 - 1 7.6 4.6 0.15 10.4 0.3 1.7 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus AMP-binding PF00501.28 EFW99106.1 - 7.7e-63 212.5 0.0 2.6e-33 115.2 0.0 2.6 1 1 1 2 2 2 2 AMP-binding enzyme ketoacyl-synt PF00109.26 EFW99106.1 - 4.4e-61 206.7 0.3 1.6e-60 204.9 0.2 2.0 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFW99106.1 - 3.5e-14 52.8 0.0 8.1e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFW99106.1 - 3.2e-06 27.4 0.0 1.5e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFW99106.1 - 1.7e-05 25.7 0.0 0.00011 23.1 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Thiolase_N PF00108.23 EFW99106.1 - 0.00055 19.4 0.2 0.001 18.5 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Pkinase PF00069.25 EFW99109.1 - 6.3e-54 183.1 0.1 6.5e-34 117.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99109.1 - 3.8e-35 121.4 0.0 4.7e-25 88.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFW99109.1 - 0.00028 20.3 0.1 0.0011 18.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFW99109.1 - 0.031 13.1 0.9 0.14 10.9 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase DUF3896 PF13035.6 EFW99109.1 - 0.12 12.6 2.5 0.21 11.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) APG6 PF04111.12 EFW99110.1 - 1.5e-70 236.8 0.0 2.3e-70 236.2 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EFW99110.1 - 1.6e-35 122.6 17.0 2.1e-35 122.1 17.0 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region Rpr2 PF04032.16 EFW99110.1 - 0.082 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain V_ATPase_I PF01496.19 EFW99110.1 - 0.52 8.2 4.1 0.7 7.7 4.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ERM PF00769.19 EFW99110.1 - 0.65 9.8 16.7 1 9.1 16.7 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family bZIP_2 PF07716.15 EFW99110.1 - 2.3 8.3 10.5 0.58 10.3 7.3 1.7 2 0 0 2 2 2 0 Basic region leucine zipper UPF0242 PF06785.11 EFW99110.1 - 3.3 7.8 11.0 6.5 6.8 11.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ssu72 PF04722.13 EFW99111.1 - 6.1e-85 283.6 0.0 6.9e-85 283.4 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein HECT PF00632.25 EFW99112.1 - 1.6e-92 310.3 0.0 2.2e-92 309.8 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EFW99112.1 - 4.1e-33 113.1 24.5 1.9e-12 47.0 4.6 3.9 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EFW99112.1 - 4.6e-21 75.1 0.0 1.3e-20 73.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain Dynamin_N PF00350.23 EFW99113.1 - 1.7e-15 57.5 0.0 5.2e-15 55.9 0.0 1.9 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EFW99113.1 - 5.3e-05 23.3 0.0 0.00056 20.0 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFW99113.1 - 6.7e-05 23.4 0.0 0.0021 18.6 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 EFW99113.1 - 0.0038 16.6 0.0 0.07 12.4 0.0 2.9 4 0 0 4 4 4 1 AIG1 family Zeta_toxin PF06414.12 EFW99113.1 - 0.0043 16.3 0.0 0.015 14.6 0.0 1.9 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EFW99113.1 - 0.015 15.7 0.5 0.11 12.8 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EFW99113.1 - 0.03 14.6 0.3 2.2 8.5 0.0 4.0 4 1 0 4 4 4 0 AAA domain IIGP PF05049.13 EFW99113.1 - 0.039 13.0 0.5 1.1 8.2 0.0 2.9 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) ATG_C PF09333.11 EFW99113.1 - 0.046 14.1 0.0 0.23 11.8 0.0 2.2 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain RsgA_GTPase PF03193.16 EFW99113.1 - 0.071 13.0 0.1 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase SMC_N PF02463.19 EFW99113.1 - 0.092 12.2 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFW99113.1 - 0.38 11.2 0.1 0.38 11.2 0.1 2.3 2 1 0 2 2 2 0 AAA domain Ank_2 PF12796.7 EFW99114.1 - 6.4e-48 161.3 14.6 5.1e-14 52.6 0.3 6.3 2 1 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFW99114.1 - 4.8e-38 128.7 17.8 0.00013 22.2 0.0 9.2 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFW99114.1 - 1.2e-37 127.8 8.2 1e-07 32.4 0.1 7.3 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW99114.1 - 6.8e-36 118.2 8.1 6.6e-06 26.1 0.0 10.7 10 0 0 10 10 10 7 Ankyrin repeat Ank PF00023.30 EFW99114.1 - 3.2e-28 96.9 21.0 0.0019 18.6 0.1 10.5 10 0 0 10 10 10 8 Ankyrin repeat PPR_3 PF13812.6 EFW99114.1 - 0.11 12.6 0.3 28 4.9 0.1 3.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Vps54_N PF10475.9 EFW99114.1 - 0.11 11.7 2.2 18 4.5 0.1 3.1 3 0 0 3 3 3 0 Vacuolar-sorting protein 54, of GARP complex DivIVA PF05103.13 EFW99114.1 - 0.58 10.2 0.0 0.58 10.2 0.0 2.8 3 0 0 3 3 3 0 DivIVA protein vATP-synt_E PF01991.18 EFW99115.1 - 1.4e-60 204.2 3.3 1.6e-60 203.9 3.3 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF3293 PF11697.8 EFW99115.1 - 0.13 12.8 1.7 0.73 10.4 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3293) Sedlin_N PF04628.13 EFW99116.1 - 5.8e-10 39.4 0.0 8.1e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF3446 PF11928.8 EFW99116.1 - 0.16 12.3 5.7 0.72 10.2 0.1 2.5 2 1 1 3 3 3 0 Early growth response N-terminal domain CDC50 PF03381.15 EFW99117.1 - 1.1e-97 327.0 0.0 1.4e-97 326.6 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF3185 PF11381.8 EFW99117.1 - 0.4 10.7 4.5 0.99 9.5 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) Asp4 PF16996.5 EFW99117.1 - 0.49 10.2 1.1 1.1 9.1 1.1 1.5 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 RdRP PF05183.12 EFW99118.1 - 1.5e-185 618.2 0.0 1.9e-185 617.9 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase FAD-oxidase_C PF02913.19 EFW99118.1 - 1.4e-56 192.0 0.2 2.6e-56 191.0 0.2 1.5 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFW99118.1 - 2.1e-33 115.0 0.0 4.5e-33 113.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain hnRNP_Q_AcD PF18360.1 EFW99118.1 - 0.00056 19.8 0.0 0.0016 18.4 0.0 1.8 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain HNH_2 PF13391.6 EFW99119.1 - 0.021 15.0 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 HNH endonuclease Pneumo_ncap PF03246.13 EFW99119.1 - 0.033 12.9 0.3 0.051 12.3 0.3 1.2 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein WD40 PF00400.32 EFW99120.1 - 1.9e-17 63.3 26.3 7.7e-05 23.4 0.4 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99120.1 - 4.9e-06 26.8 0.0 0.0022 18.2 0.0 3.4 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFW99120.1 - 0.021 13.3 2.6 5.2 5.5 0.0 3.8 3 1 1 4 4 4 0 Cytochrome D1 heme domain PD40 PF07676.12 EFW99120.1 - 4.2 7.4 7.6 0.29 11.1 0.2 2.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat MBOAT PF03062.19 EFW99121.1 - 1e-42 146.8 22.7 1e-42 146.8 22.7 2.4 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EFW99121.1 - 0.00042 20.5 5.1 0.00042 20.5 5.1 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Lipoprotein_3 PF00938.17 EFW99122.1 - 0.089 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipoprotein MFS_1 PF07690.16 EFW99123.1 - 4.7e-18 65.2 35.6 1.4e-17 63.7 32.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily CLTH PF10607.9 EFW99124.1 - 9e-30 103.5 0.0 1.5e-29 102.8 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain adh_short PF00106.25 EFW99125.1 - 1.2e-37 129.3 2.4 2.1e-36 125.3 2.4 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW99125.1 - 5.9e-36 124.2 4.6 1.8e-29 103.0 2.6 2.7 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW99125.1 - 7.8e-14 52.0 1.9 1e-11 45.1 1.9 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFW99125.1 - 0.00063 19.3 0.6 0.0027 17.2 0.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EFW99125.1 - 0.017 14.5 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EFW99125.1 - 0.022 14.2 0.0 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 EFW99125.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NapE PF06796.11 EFW99126.1 - 0.088 12.4 1.3 0.96 9.0 0.1 2.3 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE UMP1 PF05348.11 EFW99127.1 - 4.7e-37 126.8 0.0 5.8e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 U3_snoRNA_assoc PF08297.11 EFW99128.1 - 4.1e-13 49.8 0.2 4.1e-13 49.8 0.2 3.1 2 1 0 2 2 2 1 U3 snoRNA associated MRP-S31 PF15433.6 EFW99128.1 - 0.9 9.2 10.3 1.1 8.8 10.3 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Spt5_N PF11942.8 EFW99128.1 - 1.8 9.6 24.7 18 6.4 0.0 2.6 2 1 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal GREB1 PF15782.5 EFW99128.1 - 4.5 4.3 8.4 5 4.1 8.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Spem1 PF15670.5 EFW99128.1 - 6.1 6.3 6.8 2.5 7.6 4.4 1.4 1 1 0 1 1 1 0 Spermatid maturation protein 1 PhoLip_ATPase_C PF16212.5 EFW99129.1 - 9e-78 261.5 29.9 9e-78 261.5 29.9 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFW99129.1 - 6.9e-19 67.3 0.4 2.1e-18 65.8 0.4 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFW99129.1 - 1.2e-12 47.7 0.3 8.6e-12 45.0 0.0 2.4 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFW99129.1 - 6.2e-11 43.0 1.3 1.2e-07 32.3 0.3 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFW99129.1 - 0.025 14.3 0.8 0.059 13.1 0.8 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFW99129.1 - 0.034 13.7 0.0 0.034 13.7 0.0 2.6 3 1 0 3 3 3 0 E1-E2 ATPase PBP1_TM PF14812.6 EFW99129.1 - 3.3 8.1 5.9 16 6.0 5.9 2.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aminotran_3 PF00202.21 EFW99130.1 - 7.4e-117 390.4 0.0 8.7e-117 390.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III RasGAP PF00616.19 EFW99132.1 - 1.5e-52 178.4 0.0 3.8e-52 177.0 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFW99132.1 - 4.4e-47 159.7 3.2 4.4e-47 159.7 3.2 2.6 2 0 0 2 2 2 1 RasGAP C-terminus IQ PF00612.27 EFW99132.1 - 3.9e-16 57.3 51.6 0.065 13.1 0.4 14.3 16 0 0 16 16 16 9 IQ calmodulin-binding motif CH PF00307.31 EFW99132.1 - 5.7e-09 36.1 0.0 1.8e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain TPR_4 PF07721.14 EFW99134.1 - 0.0053 17.3 1.6 0.0053 17.3 1.6 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TauD PF02668.16 EFW99135.1 - 1.7e-37 129.6 0.1 2.4e-37 129.2 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PPR_2 PF13041.6 EFW99136.1 - 2.6e-28 98.0 0.7 1.8e-10 40.8 0.1 6.0 4 2 2 6 6 6 4 PPR repeat family PPR_1 PF12854.7 EFW99136.1 - 1.1e-21 76.2 0.6 6.2e-10 38.6 0.0 6.3 7 0 0 7 7 7 3 PPR repeat PPR_3 PF13812.6 EFW99136.1 - 1.4e-15 57.1 0.0 2.9e-06 27.3 0.0 2.9 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR PF01535.20 EFW99136.1 - 3.7e-14 51.9 6.1 0.00044 20.3 0.0 6.1 6 0 0 6 6 6 3 PPR repeat PPR_long PF17177.4 EFW99136.1 - 0.0086 15.5 0.0 1.3 8.4 0.0 2.5 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP RNase_PH PF01138.21 EFW99137.1 - 2.7e-19 70.0 0.0 1.9e-18 67.2 0.0 2.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 GDI PF00996.18 EFW99138.1 - 5.7e-23 81.1 0.0 2.4e-10 39.5 0.0 2.4 2 1 0 2 2 2 2 GDP dissociation inhibitor F_bP_aldolase PF01116.20 EFW99139.1 - 1.7e-92 309.9 0.0 1.9e-92 309.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Torsin PF06309.11 EFW99139.1 - 0.13 12.4 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 Torsin Methyltransf_25 PF13649.6 EFW99140.1 - 8.3e-19 68.1 0.0 1.6e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW99140.1 - 1.3e-15 57.8 0.0 2.6e-15 56.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99140.1 - 1.2e-09 38.1 0.0 1.6e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW99140.1 - 3e-08 33.7 0.0 4.8e-08 33.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99140.1 - 4.2e-07 30.6 0.0 7.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFW99140.1 - 0.0018 17.6 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UPF0146 PF03686.13 EFW99140.1 - 0.0087 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0146) MTS PF05175.14 EFW99140.1 - 0.062 12.8 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain MetW PF07021.12 EFW99140.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW adh_short PF00106.25 EFW99140.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase ABC_tran PF00005.27 EFW99141.1 - 4.4e-42 143.8 0.0 4.2e-30 105.1 0.0 3.3 2 1 1 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EFW99141.1 - 5.3e-38 131.2 23.3 1.3e-26 93.9 11.3 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFW99141.1 - 2.8e-08 33.5 0.4 0.00057 19.4 0.1 3.7 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFW99141.1 - 0.00035 20.3 0.6 0.24 11.2 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFW99141.1 - 0.00036 20.9 0.4 0.25 11.7 0.2 2.8 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EFW99141.1 - 0.00068 19.7 0.4 0.083 13.0 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EFW99141.1 - 0.00075 20.1 0.2 0.089 13.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFW99141.1 - 0.001 19.3 0.2 2.5 8.4 0.1 3.2 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 EFW99141.1 - 0.0012 19.0 1.4 0.26 11.4 0.0 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 EFW99141.1 - 0.0014 18.5 0.1 0.82 9.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 EFW99141.1 - 0.0038 16.3 0.0 0.093 11.8 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_21 PF13304.6 EFW99141.1 - 0.0053 16.6 0.4 12 5.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EFW99141.1 - 0.02 14.5 0.1 0.99 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFW99141.1 - 0.029 13.6 0.2 6 6.1 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.9 EFW99141.1 - 0.049 12.9 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MeaB PF03308.16 EFW99141.1 - 0.055 12.4 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4366 PF14283.6 EFW99141.1 - 0.071 13.2 1.9 3.7 7.6 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) NACHT PF05729.12 EFW99141.1 - 0.076 12.9 0.3 0.77 9.7 0.0 2.7 3 0 0 3 3 3 0 NACHT domain CbiA PF01656.23 EFW99141.1 - 0.2 11.7 1.2 18 5.4 0.5 2.9 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2207 PF09972.9 EFW99141.1 - 1.3 7.7 10.6 2 7.1 0.2 3.8 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) SprT-like PF10263.9 EFW99142.1 - 4.7e-12 45.8 0.0 8.3e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 SprT-like family UCH_C PF18031.1 EFW99143.1 - 0.008 16.1 2.4 0.019 14.9 2.4 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Adaptin_N PF01602.20 EFW99144.1 - 3.3e-119 398.8 9.6 4.2e-119 398.5 9.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFW99144.1 - 2.4e-55 187.0 0.2 2.4e-55 187.0 0.2 3.6 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFW99144.1 - 6.5e-13 48.9 8.4 6.4e-06 26.5 0.1 5.4 4 2 1 5 5 5 2 HEAT repeats HEAT PF02985.22 EFW99144.1 - 1e-07 31.5 6.3 0.0035 17.5 0.0 5.7 6 0 0 6 6 6 2 HEAT repeat CLASP_N PF12348.8 EFW99144.1 - 0.00045 19.9 1.7 0.21 11.1 0.0 3.2 3 0 0 3 3 3 2 CLASP N terminal Atx10homo_assoc PF09759.9 EFW99144.1 - 0.003 17.6 0.1 11 6.2 0.0 4.0 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 EFW99144.1 - 0.012 16.1 7.5 39 4.9 0.1 6.1 5 1 1 6 6 6 0 HEAT-like repeat DUF4042 PF13251.6 EFW99144.1 - 0.048 13.4 0.2 2.4 7.8 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) Arm PF00514.23 EFW99144.1 - 0.13 12.4 3.0 3.8 7.7 0.0 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RRP7 PF12923.7 EFW99145.1 - 5.9e-32 110.3 4.0 5.9e-32 110.3 4.0 1.6 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 EFW99145.1 - 1.5e-17 63.8 0.0 1.6e-16 60.6 0.0 2.3 2 1 0 2 2 2 1 Rrp7 RRM-like N-terminal domain MAM33 PF02330.16 EFW99145.1 - 0.33 10.9 3.1 0.2 11.6 1.0 1.6 2 0 0 2 2 2 0 Mitochondrial glycoprotein SMC_N PF02463.19 EFW99146.1 - 2.1e-24 86.2 0.1 3.3e-24 85.6 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFW99146.1 - 1e-11 45.7 20.5 1e-11 45.7 20.5 5.3 3 1 1 4 4 4 1 AAA domain AAA_15 PF13175.6 EFW99146.1 - 1.1e-09 38.4 4.0 2e-08 34.4 0.7 2.5 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFW99146.1 - 2.7e-06 27.4 1.2 0.0057 16.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFW99146.1 - 0.011 15.5 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFW99146.1 - 0.35 11.4 0.0 0.35 11.4 0.0 5.5 3 2 0 3 3 3 0 ABC transporter AAA_27 PF13514.6 EFW99146.1 - 0.36 10.4 0.0 0.36 10.4 0.0 4.4 4 1 0 4 4 4 0 AAA domain Toxin_36 PF10550.9 EFW99146.1 - 3 9.4 5.2 88 4.9 0.1 4.1 3 0 0 3 3 3 0 Conantokin-G mollusc-toxin MOZ_SAS PF01853.18 EFW99147.1 - 1.9e-79 265.5 0.0 2.7e-79 265.0 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFW99147.1 - 1.5e-21 75.7 0.9 3e-21 74.8 0.9 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EFW99147.1 - 2e-16 59.6 0.0 4.7e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EFW99147.1 - 0.00051 20.4 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFW99147.1 - 0.0038 17.4 0.0 0.0078 16.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DDHD PF02862.17 EFW99148.1 - 5e-61 206.7 8.3 8.9e-61 205.9 0.0 3.4 3 1 0 3 3 3 1 DDHD domain Dabb PF07876.12 EFW99149.1 - 4e-24 85.1 0.0 4.6e-24 84.9 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Pex24p PF06398.11 EFW99151.1 - 1.3e-79 267.8 0.0 1.6e-79 267.6 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 EFW99151.1 - 0.025 12.9 0.0 0.044 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Phageshock_PspG PF09583.10 EFW99151.1 - 2.7 8.3 4.6 0.56 10.5 0.3 1.9 2 0 0 2 2 2 0 Phage shock protein G (Phageshock_PspG) Lyase_1 PF00206.20 EFW99152.1 - 2.3e-111 372.1 0.0 3.2e-111 371.7 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EFW99152.1 - 5.6e-22 77.9 0.0 1.3e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus CENP-O PF09496.10 EFW99153.1 - 4.3e-65 219.7 0.0 7.7e-65 218.8 0.0 1.4 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component SRAP PF02586.14 EFW99154.1 - 3.6e-62 209.8 0.0 5.9e-62 209.1 0.0 1.3 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) NAD_binding_1 PF00175.21 EFW99155.1 - 7.1e-29 100.6 0.0 1.1e-28 100.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFW99155.1 - 1e-22 80.3 0.0 1.8e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFW99155.1 - 7e-09 36.0 0.0 5.3e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EFW99155.1 - 0.047 13.9 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Syntaxin-18_N PF10496.9 EFW99156.1 - 3.3e-08 33.7 0.0 1.4e-07 31.7 0.0 2.2 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EFW99156.1 - 0.0023 17.9 0.0 0.0053 16.7 0.0 1.6 1 0 0 1 1 1 1 SNARE domain DUF1488 PF07369.11 EFW99156.1 - 0.097 12.7 0.3 0.29 11.1 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) UPF0086 PF01868.16 EFW99157.1 - 1e-29 102.3 0.2 1.7e-29 101.6 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Zn_clus PF00172.18 EFW99158.1 - 9.7e-06 25.6 11.0 2.4e-05 24.4 11.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFW99158.1 - 1.8e-05 23.9 0.0 4.3e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain DEAD PF00270.29 EFW99159.1 - 4.3e-39 134.1 0.0 7e-39 133.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW99159.1 - 7.1e-26 90.7 0.3 4.8e-24 84.8 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99159.1 - 4e-09 36.7 0.0 8.6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4844 PF16133.5 EFW99159.1 - 0.082 13.5 0.5 0.2 12.2 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) Sas10_Utp3 PF04000.15 EFW99161.1 - 3.7e-14 53.1 0.2 8.2e-14 52.0 0.0 1.6 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Syntaxin PF00804.25 EFW99161.1 - 0.088 12.5 0.6 0.15 11.7 0.6 1.3 1 0 0 1 1 1 0 Syntaxin DUF1192 PF06698.11 EFW99161.1 - 0.097 12.7 1.8 0.62 10.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) LicD PF04991.13 EFW99162.1 - 5e-24 85.7 3.1 1.9e-16 60.9 1.1 2.2 1 1 1 2 2 2 2 LicD family F-box PF00646.33 EFW99163.1 - 0.0068 16.3 0.6 0.0068 16.3 0.6 2.4 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EFW99163.1 - 0.011 15.6 1.0 0.043 13.7 1.0 2.1 1 0 0 1 1 1 0 F-box-like MCM PF00493.23 EFW99164.1 - 2.9e-60 203.2 0.9 2.8e-47 160.7 0.1 2.3 1 1 1 2 2 2 2 MCM P-loop domain MCM_OB PF17207.3 EFW99164.1 - 3.7e-39 133.4 0.5 6.8e-39 132.6 0.5 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EFW99164.1 - 1.2e-26 93.1 0.0 3.3e-26 91.6 0.0 1.8 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EFW99164.1 - 7.9e-25 87.1 0.2 7.9e-25 87.1 0.2 2.3 3 0 0 3 3 3 1 MCM AAA-lid domain MCM_N PF14551.6 EFW99164.1 - 3.3e-19 69.4 0.0 9.6e-19 67.9 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain GIDA_assoc PF13932.6 EFW99164.1 - 0.0052 17.0 0.2 0.012 15.8 0.2 1.6 1 0 0 1 1 1 1 GidA associated domain DUF3015 PF11220.8 EFW99164.1 - 4.8 7.1 6.6 14 5.5 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3015) Helicase_C PF00271.31 EFW99167.1 - 1.1e-28 99.8 0.0 1.9e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFW99167.1 - 4.2e-28 98.3 0.0 4.7e-17 62.3 0.0 2.8 2 1 1 3 3 3 2 DEAD/DEAH box helicase RNase_H PF00075.24 EFW99168.1 - 1.5e-10 41.4 0.0 2.3e-10 40.8 0.0 1.4 1 1 0 1 1 1 1 RNase H SpoVT_C PF15714.5 EFW99170.1 - 0.049 13.7 0.0 0.083 12.9 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor Cyclin PF08613.11 EFW99171.1 - 2.6e-06 27.9 0.0 5.9e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFW99171.1 - 0.0097 15.7 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Methyltransf_23 PF13489.6 EFW99172.1 - 1.8e-19 70.1 0.0 2.8e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW99172.1 - 3.7e-16 59.6 0.0 5.8e-15 55.8 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW99172.1 - 1e-15 58.1 0.0 1.5e-13 51.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99172.1 - 3.8e-12 46.2 0.0 1.1e-10 41.5 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99172.1 - 8e-10 39.4 0.1 2.2e-08 34.8 0.0 2.9 2 2 1 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFW99172.1 - 1.8e-05 24.2 0.0 0.00026 20.4 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFW99172.1 - 0.00027 20.6 0.0 0.00075 19.1 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EFW99172.1 - 0.00031 20.9 0.0 0.00098 19.3 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EFW99172.1 - 0.0068 15.9 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 EFW99172.1 - 0.019 14.3 0.0 0.045 13.0 0.0 1.5 1 1 0 1 1 1 0 O-methyltransferase domain PrmA PF06325.13 EFW99172.1 - 0.023 14.1 0.0 0.036 13.5 0.0 1.3 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_PK PF05891.12 EFW99172.1 - 0.031 13.8 0.6 0.069 12.7 0.2 1.7 2 1 0 2 2 2 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 EFW99172.1 - 0.053 13.3 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase RRM_1 PF00076.22 EFW99173.1 - 2e-16 59.6 0.0 3.6e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GPS2_interact PF15784.5 EFW99173.1 - 0.036 14.5 1.8 0.065 13.7 1.8 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Nup35_RRM_2 PF14605.6 EFW99173.1 - 0.037 14.0 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFW99173.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif DUF724 PF05266.14 EFW99173.1 - 0.2 11.5 5.6 0.28 11.0 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Packaging_FI PF14000.6 EFW99173.1 - 0.23 11.9 3.2 0.32 11.5 3.2 1.2 1 0 0 1 1 1 0 DNA packaging protein FI Tfb5 PF06331.12 EFW99174.1 - 2.6e-26 91.4 2.4 2.9e-26 91.2 2.4 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 B-block_TFIIIC PF04182.12 EFW99174.1 - 0.12 12.5 0.1 0.14 12.3 0.1 1.1 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC RGS PF00615.19 EFW99175.1 - 7.3e-13 48.8 0.0 4.7e-11 43.0 0.0 2.3 1 1 0 1 1 1 1 Regulator of G protein signaling domain Cytochrom_B_C PF00032.17 EFW99175.1 - 0.62 10.4 3.8 0.59 10.4 1.0 2.1 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Pkinase PF00069.25 EFW99176.1 - 3.3e-74 249.6 0.0 4.7e-74 249.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99176.1 - 3.6e-37 128.0 0.0 5.2e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EFW99176.1 - 2.3e-21 76.4 0.5 2.2e-12 47.5 0.0 2.9 2 1 1 3 3 3 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EFW99176.1 - 6.7e-15 54.9 0.2 1.4e-14 53.9 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EFW99176.1 - 2.8e-05 23.6 0.0 6e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFW99176.1 - 0.0011 18.1 0.2 0.002 17.1 0.1 1.5 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 EFW99176.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFW99176.1 - 0.04 13.8 0.1 0.19 11.6 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family YukC PF10140.9 EFW99176.1 - 0.058 12.2 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF2841 PF11001.8 EFW99177.1 - 6e-41 139.4 4.0 9.1e-41 138.8 4.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Nucleoporin_C PF03177.14 EFW99179.1 - 1.8e-177 591.7 0.4 2.2e-177 591.4 0.4 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EFW99179.1 - 4.3e-69 233.3 0.0 5.7e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Acetyltransf_1 PF00583.25 EFW99180.1 - 2e-09 37.7 0.0 2.5e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFW99180.1 - 8e-07 29.4 0.0 1.3e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFW99180.1 - 0.00037 20.4 0.0 0.00049 20.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Glyoxalase PF00903.25 EFW99180.1 - 0.0015 18.8 0.0 0.0019 18.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MFS_1 PF07690.16 EFW99181.1 - 2e-45 155.2 43.4 2.1e-37 128.9 34.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFW99181.1 - 1.3e-05 23.9 32.0 5e-05 22.0 3.5 3.6 3 1 1 4 4 4 3 MFS/sugar transport protein OATP PF03137.20 EFW99181.1 - 0.0036 15.7 5.0 0.1 10.8 1.9 3.1 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family HLH PF00010.26 EFW99182.1 - 1.9e-10 40.5 0.0 6.8e-10 38.7 0.0 2.0 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DivIC PF04977.15 EFW99182.1 - 0.015 15.1 1.3 0.027 14.2 1.3 1.5 1 0 0 1 1 1 0 Septum formation initiator Cep57_CLD_2 PF14197.6 EFW99182.1 - 0.13 12.4 1.6 0.31 11.2 1.6 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Myb_DNA-binding PF00249.31 EFW99183.1 - 8.7e-16 57.9 0.3 9.4e-09 35.3 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFW99183.1 - 1.2e-11 44.6 0.1 2e-05 24.7 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFW99183.1 - 1e-05 25.5 0.1 0.21 11.6 0.0 2.5 2 0 0 2 2 2 2 SLIDE SANT_DAMP1_like PF16282.5 EFW99183.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 CHDCT2 PF08074.11 EFW99183.1 - 0.18 11.9 0.0 0.44 10.7 0.0 1.6 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Hexapep PF00132.24 EFW99184.1 - 1.2e-11 43.8 15.8 9.3e-06 25.2 7.8 3.6 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 EFW99184.1 - 7e-11 42.2 0.0 1.7e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 EFW99184.1 - 1.3e-10 40.8 18.0 7.6e-06 25.6 7.9 2.8 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Zn_clus PF00172.18 EFW99184.1 - 1.1e-09 38.3 8.7 2e-09 37.4 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nop53 PF07767.11 EFW99185.1 - 7.8e-103 344.9 29.4 9.9e-103 344.6 29.4 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) HTH_32 PF13565.6 EFW99185.1 - 0.12 13.1 3.8 1.4 9.6 1.5 3.2 2 0 0 2 2 2 0 Homeodomain-like domain HU-CCDC81_bac_1 PF18174.1 EFW99186.1 - 0.022 14.6 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 1 Fungal_trans PF04082.18 EFW99187.1 - 7.9e-17 61.1 0.0 1.2e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFW99187.1 - 1.9e-05 24.7 9.8 1.9e-05 24.7 9.8 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain USP8_interact PF08941.10 EFW99187.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 USP8 interacting Tyrosinase PF00264.20 EFW99188.1 - 9e-44 150.4 4.0 2.2e-43 149.1 4.0 1.7 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EFW99188.1 - 9.3e-22 78.0 0.0 1.8e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Tyosinase C-terminal domain DAO PF01266.24 EFW99189.1 - 9.4e-40 137.3 4.9 1.2e-39 136.9 4.9 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFW99189.1 - 3.7e-05 23.0 2.8 8.4e-05 21.8 2.8 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFW99189.1 - 5.7e-05 23.3 0.9 0.00017 21.7 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFW99189.1 - 0.0011 18.2 0.1 0.0023 17.2 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Dehydrin PF00257.19 EFW99189.1 - 0.0036 17.9 0.7 3.1 8.3 0.0 2.5 2 0 0 2 2 2 2 Dehydrin FAD_binding_3 PF01494.19 EFW99189.1 - 0.0068 15.7 0.2 0.012 14.9 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFW99189.1 - 0.036 13.3 0.0 0.081 12.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFW99189.1 - 0.13 11.6 0.2 0.19 11.1 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF3328 PF11807.8 EFW99190.1 - 1.4e-21 77.3 2.1 3.7e-20 72.6 2.1 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2671 PF10877.8 EFW99190.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2671) Myb_DNA-bind_3 PF12776.7 EFW99192.1 - 3e-23 82.6 0.2 5.1e-23 81.9 0.2 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF5353 PF17304.2 EFW99194.1 - 6.7e-13 48.2 2.5 1e-12 47.6 2.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5353) DUF883 PF05957.13 EFW99194.1 - 0.049 14.2 7.4 0.1 13.2 7.4 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) BAF1_ABF1 PF04684.13 EFW99194.1 - 0.06 12.4 0.3 0.078 12.0 0.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Nnf1 PF03980.14 EFW99195.1 - 1.8e-25 89.4 0.1 1.8e-25 89.4 0.1 2.6 3 0 0 3 3 3 1 Nnf1 SDA1 PF05285.12 EFW99195.1 - 0.71 9.2 13.3 2.3 7.6 10.9 2.0 2 0 0 2 2 2 0 SDA1 Med4 PF10018.9 EFW99195.1 - 0.83 9.3 0.0 0.83 9.3 0.0 2.3 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 TRAP_alpha PF03896.16 EFW99195.1 - 4.7 6.3 7.3 6.7 5.8 7.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PalH PF08733.10 EFW99196.1 - 0.12 11.4 3.7 0.18 10.8 3.7 1.2 1 0 0 1 1 1 0 PalH/RIM21 DsbD_2 PF13386.6 EFW99196.1 - 0.29 11.0 10.2 0.46 10.4 10.2 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region TauD PF02668.16 EFW99197.1 - 4.5e-44 151.2 0.1 5.4e-44 151.0 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Peptidase_C80 PF11713.8 EFW99197.1 - 0.004 17.4 0.1 0.0062 16.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase C80 family BUD22 PF09073.10 EFW99198.1 - 0.21 10.9 18.1 0.31 10.3 0.4 2.3 2 0 0 2 2 2 0 BUD22 DUF572 PF04502.13 EFW99198.1 - 8.6 5.9 12.1 2.5 7.6 8.7 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF572) ApoLp-III PF07464.11 EFW99199.1 - 0.054 13.6 5.8 0.1 12.7 5.8 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Ribosomal_L31e PF01198.19 EFW99200.1 - 2.8e-40 136.4 0.5 3.6e-40 136.1 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e IMPDH PF00478.25 EFW99201.1 - 4.4e-127 423.8 3.3 5.1e-127 423.6 3.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EFW99201.1 - 1.3e-15 57.5 0.6 1.4e-07 31.8 0.2 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 EFW99201.1 - 1.5e-08 34.4 3.2 0.0017 17.8 3.1 2.6 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EFW99201.1 - 3.5e-08 32.9 0.6 3.1e-06 26.5 0.3 2.4 2 0 0 2 2 2 2 FMN-dependent dehydrogenase His_biosynth PF00977.21 EFW99201.1 - 0.00012 21.6 2.0 0.026 14.0 0.2 2.5 1 1 1 2 2 2 2 Histidine biosynthesis protein ThiG PF05690.14 EFW99201.1 - 0.029 13.7 0.7 0.078 12.3 0.2 1.9 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG YpsA PF06908.11 EFW99201.1 - 0.035 14.1 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family PK PF00224.21 EFW99201.1 - 0.068 12.0 0.0 0.21 10.4 0.0 1.7 1 1 0 1 1 1 0 Pyruvate kinase, barrel domain cNMP_binding PF00027.29 EFW99202.1 - 5.7e-39 132.1 0.0 3.1e-20 72.0 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RNase_H2_suC PF08615.11 EFW99203.1 - 6.8e-25 87.9 0.0 9.2e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) APH PF01636.23 EFW99204.1 - 1.8e-17 64.1 1.0 9.8e-08 32.2 0.0 3.5 2 1 1 3 3 3 3 Phosphotransferase enzyme family zf-AN1 PF01428.16 EFW99204.1 - 0.0071 16.5 8.2 0.012 15.7 8.2 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger HCBP_related PF06594.11 EFW99204.1 - 0.13 12.2 3.6 13 5.9 0.0 3.3 4 0 0 4 4 4 0 Haemolysin-type calcium binding protein related domain UTP25 PF06862.12 EFW99207.1 - 2.5e-180 600.3 0.0 2.5e-179 597.0 0.0 2.0 1 1 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EFW99207.1 - 0.022 14.6 0.0 0.61 9.8 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase TFIIA PF03153.13 EFW99207.1 - 0.22 11.5 19.6 0.39 10.7 19.6 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 EFW99207.1 - 4.7 5.3 27.6 8.1 4.5 27.6 1.4 1 0 0 1 1 1 0 Nop14-like family eIF-5_eIF-2B PF01873.17 EFW99208.1 - 4.8e-41 139.3 0.2 6.8e-41 138.8 0.2 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 zf_C2H2_13 PF18508.1 EFW99208.1 - 0.089 12.4 1.5 3.3 7.4 0.1 2.3 2 0 0 2 2 2 0 Zinc finger domain TF_Zn_Ribbon PF08271.12 EFW99208.1 - 0.091 12.3 0.5 0.18 11.3 0.5 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Arc_trans_TRASH PF08394.10 EFW99208.1 - 0.6 10.5 6.5 1.5 9.2 0.2 2.4 1 1 1 2 2 2 0 Archaeal TRASH domain DUF3807 PF12720.7 EFW99209.1 - 8.6e-16 58.7 7.3 2.2e-12 47.6 0.8 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3807) Spore_YpjB PF09577.10 EFW99209.1 - 0.08 12.7 0.5 0.12 12.1 0.5 1.2 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) Oxidored_q6 PF01058.22 EFW99210.1 - 1.6e-22 79.7 0.0 2.4e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Tyrosinase PF00264.20 EFW99211.1 - 5.1e-50 170.8 0.0 6.7e-50 170.4 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase SnoaL PF07366.12 EFW99212.1 - 0.0058 16.4 0.0 0.019 14.8 0.0 1.8 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EFW99212.1 - 0.025 15.2 0.1 0.057 14.1 0.1 1.6 1 0 0 1 1 1 0 SnoaL-like domain RNase_P_p30 PF01876.16 EFW99213.1 - 5.1e-48 163.4 0.0 1.7e-47 161.7 0.0 1.9 1 1 0 1 1 1 1 RNase P subunit p30 zinc_ribbon_15 PF17032.5 EFW99213.1 - 0.0032 18.2 0.8 0.0032 18.2 0.8 2.9 3 0 0 3 3 3 1 zinc-ribbon family GFA PF04828.14 EFW99213.1 - 0.0068 16.7 2.8 0.0068 16.7 2.8 3.6 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Plasmodium_HRP PF05403.11 EFW99213.1 - 0.077 12.8 2.3 0.13 12.0 2.3 1.3 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) DUF4956 PF16316.5 EFW99213.1 - 5.3 6.7 5.4 9.1 5.9 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Raftlin PF15250.6 EFW99213.1 - 5.6 5.6 7.1 13 4.4 7.1 1.5 1 0 0 1 1 1 0 Raftlin Ctr PF04145.15 EFW99214.1 - 6.3e-30 104.8 0.0 6.3e-30 104.8 0.0 1.7 2 1 0 2 2 2 1 Ctr copper transporter family RRM_1 PF00076.22 EFW99214.1 - 0.0027 17.5 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4381 PF14316.6 EFW99214.1 - 0.039 14.2 0.2 7.2 6.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) PAP2 PF01569.21 EFW99214.1 - 0.066 13.0 1.2 0.16 11.7 1.2 1.6 1 1 0 1 1 1 0 PAP2 superfamily SRI PF08236.11 EFW99215.1 - 8.2e-22 77.2 1.9 2.3e-21 75.7 1.9 1.8 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain AWS PF17907.1 EFW99215.1 - 2.2e-13 50.0 11.9 2.2e-13 50.0 11.9 1.7 2 0 0 2 2 2 1 AWS domain SET PF00856.28 EFW99215.1 - 4.9e-13 49.8 6.8 4.9e-13 49.8 6.8 4.0 2 2 0 2 2 2 1 SET domain WW PF00397.26 EFW99215.1 - 0.00058 19.9 0.5 0.0018 18.3 0.5 1.9 1 0 0 1 1 1 1 WW domain Med26 PF08711.11 EFW99215.1 - 0.0013 18.7 2.4 0.0021 18.0 0.2 2.5 2 0 0 2 2 2 1 TFIIS helical bundle-like domain BAR PF03114.18 EFW99216.1 - 1.2e-64 218.2 9.9 1.7e-64 217.7 9.9 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EFW99216.1 - 6.8e-14 51.2 0.1 6.8e-14 51.2 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EFW99216.1 - 7.3e-11 41.8 0.1 1.6e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFW99216.1 - 9.5e-10 38.0 0.7 3.5e-09 36.2 0.0 2.2 3 0 0 3 3 3 1 Variant SH3 domain DUF2205 PF10224.9 EFW99216.1 - 0.32 11.0 4.4 5.7 7.0 0.1 3.3 2 1 1 3 3 3 0 Short coiled-coil protein TMPIT PF07851.13 EFW99216.1 - 9.3 5.4 6.8 2.2 7.4 0.2 2.1 1 1 1 2 2 2 0 TMPIT-like protein MFS_1 PF07690.16 EFW99217.1 - 4.5e-35 121.2 23.4 4.5e-35 121.2 23.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW99217.1 - 2e-07 30.3 15.2 5.6e-07 28.8 15.3 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter LapA_dom PF06305.11 EFW99217.1 - 2.1 8.2 4.6 11 6.0 0.2 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Ran_BP1 PF00638.18 EFW99218.1 - 1.1e-14 54.7 0.1 4.1e-14 52.9 0.1 1.9 1 1 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.6 EFW99218.1 - 2.8e-07 31.3 45.4 1.2e-05 26.0 12.1 11.1 2 1 8 10 10 10 4 Nucleoporin FG repeat region DFRP_C PF16543.5 EFW99218.1 - 1.3 9.5 3.4 2.9 8.4 0.1 3.0 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 DUF2431 PF10354.9 EFW99219.1 - 3.5e-62 209.6 0.0 4.3e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) GGA_N-GAT PF18308.1 EFW99220.1 - 0.049 13.3 0.1 0.071 12.7 0.1 1.3 1 0 0 1 1 1 0 GGA N-GAT domain NOA36 PF06524.12 EFW99221.1 - 9.3 5.5 6.9 17 4.6 6.9 1.3 1 0 0 1 1 1 0 NOA36 protein zf-CCHC_3 PF13917.6 EFW99222.1 - 3.7e-10 39.6 1.3 6.9e-10 38.7 1.3 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF3664 PF12406.8 EFW99222.1 - 0.067 13.8 0.5 0.09 13.4 0.5 1.1 1 0 0 1 1 1 0 Surface protein DUF1522 PF07482.11 EFW99223.1 - 0.0018 18.6 0.6 0.0052 17.1 0.6 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1522) Glyco_hydro_72 PF03198.14 EFW99224.1 - 1.3e-122 409.0 1.4 1.6e-122 408.7 1.4 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EFW99224.1 - 4.1e-08 33.0 0.8 3.3e-07 30.0 0.8 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4764 PF15961.5 EFW99225.1 - 0.012 14.4 0.6 0.019 13.7 0.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4764) DUF5527 PF17665.1 EFW99225.1 - 0.26 10.8 6.2 0.45 10.0 6.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Macoilin PF09726.9 EFW99225.1 - 0.42 9.1 2.0 0.44 9.1 2.0 1.1 1 0 0 1 1 1 0 Macoilin family Ribosomal_L14e PF01929.17 EFW99226.1 - 5e-31 107.0 4.5 1e-30 106.1 4.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.29 EFW99226.1 - 0.00012 21.9 0.1 0.00034 20.5 0.0 1.9 2 0 0 2 2 2 1 KOW motif DUF4913 PF16259.5 EFW99226.1 - 0.03 14.4 0.2 0.049 13.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) Glyco_tran_28_C PF04101.16 EFW99227.1 - 1.2e-13 51.4 0.0 3e-13 50.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SRF-TF PF00319.18 EFW99228.1 - 4.1e-21 74.2 0.1 5.9e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) PH_9 PF15410.6 EFW99229.1 - 1.6e-05 25.3 0.0 3.4e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Adeno_PIX PF03955.14 EFW99229.1 - 0.14 12.3 12.0 0.34 11.1 12.0 1.6 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) KdgT PF03812.13 EFW99229.1 - 9.5 5.4 6.9 13 5.0 6.9 1.1 1 0 0 1 1 1 0 2-keto-3-deoxygluconate permease Aminotran_1_2 PF00155.21 EFW99230.1 - 7.6e-84 281.9 0.0 8.7e-84 281.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Lyase_1 PF00206.20 EFW99231.1 - 7.2e-88 295.0 0.0 9.9e-88 294.5 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EFW99231.1 - 5.5e-22 78.3 0.2 1.2e-21 77.2 0.2 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal SPO22 PF08631.10 EFW99231.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Isy1 PF06246.12 EFW99232.1 - 1.6e-89 299.9 0.1 1.7e-89 299.7 0.1 1.0 1 0 0 1 1 1 1 Isy1-like splicing family ABC_membrane PF00664.23 EFW99233.1 - 4.9e-85 285.5 38.2 3.3e-44 151.6 8.4 2.7 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFW99233.1 - 2.1e-50 170.8 0.0 4.2e-30 105.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFW99233.1 - 8.4e-11 41.7 0.0 0.00019 20.9 0.0 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MTABC_N PF16185.5 EFW99233.1 - 7.5e-09 35.4 10.1 1.9e-08 34.1 10.1 1.7 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region MMR_HSR1 PF01926.23 EFW99233.1 - 6.6e-06 26.2 0.2 0.18 11.9 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFW99233.1 - 2.8e-05 23.8 1.0 0.23 11.2 0.1 3.2 3 0 0 3 3 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFW99233.1 - 4.1e-05 23.5 0.0 0.048 13.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EFW99233.1 - 5.3e-05 23.7 0.2 0.17 12.2 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFW99233.1 - 0.00027 20.9 0.9 0.049 13.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFW99233.1 - 0.00045 20.8 0.1 0.04 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFW99233.1 - 0.0034 17.7 0.0 0.2 12.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Dynamin_N PF00350.23 EFW99233.1 - 0.005 16.9 0.3 0.65 10.0 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_15 PF13175.6 EFW99233.1 - 0.0059 16.4 0.1 0.25 11.0 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EFW99233.1 - 0.0067 16.2 1.0 0.14 11.9 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFW99233.1 - 0.011 15.3 0.0 0.53 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFW99233.1 - 0.029 14.7 2.6 4.1 7.7 0.1 3.3 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFW99233.1 - 0.037 13.8 0.0 10 5.8 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 EFW99233.1 - 0.039 13.5 0.1 2.2 7.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 EFW99233.1 - 0.07 12.3 0.1 4.3 6.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 EFW99233.1 - 0.12 12.6 0.2 21 5.4 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EFW99233.1 - 0.21 11.7 0.7 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain UBA PF00627.31 EFW99234.1 - 2.1e-25 88.2 7.0 1.4e-13 50.5 0.5 2.6 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 EFW99234.1 - 1.4e-24 85.5 14.2 2.6e-24 84.7 14.2 1.5 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EFW99234.1 - 4.4e-21 74.4 0.2 7.9e-21 73.6 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFW99234.1 - 1.5e-08 34.3 0.4 2.6e-08 33.5 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EFW99234.1 - 0.00034 20.3 0.0 0.37 10.6 0.0 2.4 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.6 EFW99234.1 - 0.0052 16.9 0.0 0.012 15.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFW99234.1 - 0.015 15.7 0.1 0.041 14.3 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 EFW99234.1 - 0.017 15.7 0.0 0.034 14.7 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain ALIX_LYPXL_bnd PF13949.6 EFW99234.1 - 0.042 13.1 0.0 0.37 10.1 0.1 2.0 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV WIYLD PF10440.9 EFW99234.1 - 0.05 13.4 0.2 0.79 9.6 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain eIF-5a PF01287.20 EFW99234.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Ubiquitin_5 PF18037.1 EFW99234.1 - 0.067 13.5 0.3 0.14 12.6 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain MCM_N PF14551.6 EFW99234.1 - 0.13 12.9 0.1 0.29 11.7 0.1 1.5 1 0 0 1 1 1 0 MCM N-terminal domain NUDE_C PF04880.13 EFW99234.1 - 0.28 11.6 2.7 0.66 10.4 2.7 1.7 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Peptidase_S15 PF02129.18 EFW99234.1 - 0.33 10.5 3.6 0.21 11.1 0.4 1.9 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Rib_recp_KP_reg PF05104.12 EFW99234.1 - 4.8 8.2 23.0 0.11 13.5 11.0 2.4 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Tyrosinase PF00264.20 EFW99235.1 - 4.1e-41 141.7 7.3 6.2e-41 141.1 7.3 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase SUZ PF12752.7 EFW99236.1 - 2.1e-12 47.6 4.3 2.1e-12 47.6 4.3 2.7 2 0 0 2 2 2 1 SUZ domain R3H PF01424.22 EFW99236.1 - 2.3e-07 30.7 0.0 4.5e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 R3H domain ABC_tran PF00005.27 EFW99237.1 - 2.7e-21 76.5 0.0 5.8e-10 39.8 0.0 3.5 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFW99237.1 - 5.3e-08 33.0 0.0 0.05 13.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EFW99237.1 - 2.4e-07 30.9 0.0 0.00021 21.5 0.0 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFW99237.1 - 0.0003 20.5 0.1 0.057 13.2 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFW99237.1 - 0.0013 19.0 0.1 1.7 8.9 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_33 PF13671.6 EFW99237.1 - 0.0014 18.8 0.0 0.58 10.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EFW99237.1 - 0.0018 18.8 0.1 0.098 13.1 0.2 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFW99237.1 - 0.0022 18.4 0.1 1.2 9.5 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EFW99237.1 - 0.0041 16.9 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain ATP_bind_1 PF03029.17 EFW99237.1 - 0.012 15.4 0.0 4.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 EFW99237.1 - 0.014 15.8 0.0 0.55 10.7 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFW99237.1 - 0.026 15.1 0.0 4.4 7.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFW99237.1 - 0.039 14.3 0.0 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EFW99237.1 - 0.069 13.4 0.1 6.4 7.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain NACHT PF05729.12 EFW99237.1 - 0.13 12.1 0.0 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.9 EFW99237.1 - 0.14 11.8 0.0 8.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EFW99237.1 - 0.28 10.7 0.1 1.3 8.6 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MPC PF03650.13 EFW99238.1 - 1.3e-45 154.1 0.6 1.8e-45 153.6 0.6 1.3 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers TadE PF07811.12 EFW99238.1 - 0.14 12.5 0.1 0.14 12.5 0.1 2.6 3 0 0 3 3 3 0 TadE-like protein WD40 PF00400.32 EFW99239.1 - 2.4e-11 44.0 10.5 0.087 13.7 0.1 6.2 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99239.1 - 0.00024 21.3 0.0 0.39 11.0 0.0 3.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Gln_amidase PF15644.6 EFW99239.1 - 0.051 14.6 0.6 0.19 12.8 0.6 2.1 1 1 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase BCAS2 PF05700.11 EFW99240.1 - 1.8e-56 191.2 8.5 2.1e-56 190.9 8.5 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Coilin_N PF15862.5 EFW99241.1 - 1.1 9.1 6.1 0.81 9.5 4.9 1.4 1 1 0 1 1 1 0 Coilin N-terminus Myb_DNA-bind_7 PF15963.5 EFW99242.1 - 1.2e-22 79.6 0.0 2.8e-22 78.4 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EFW99242.1 - 1.9e-07 31.2 0.0 3.6e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain tRNA-synt_2 PF00152.20 EFW99243.1 - 9.3e-70 235.2 0.0 1.1e-69 234.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) G0-G1_switch_2 PF15103.6 EFW99243.1 - 0.12 12.8 0.8 0.42 11.1 0.0 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 INSIG PF07281.12 EFW99244.1 - 0.12 12.0 0.2 0.18 11.4 0.2 1.3 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Aminotran_1_2 PF00155.21 EFW99246.1 - 8.5e-19 67.9 0.0 1.2e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II SH3_1 PF00018.28 EFW99247.1 - 2.3e-08 33.5 0.0 4.8e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFW99247.1 - 2.3e-06 27.3 0.1 5.3e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFW99247.1 - 0.00029 20.4 0.0 0.00078 19.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Atg14 PF10186.9 EFW99248.1 - 9.3e-68 228.7 0.0 1.3e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ECM11 PF15463.6 EFW99248.1 - 0.21 12.1 8.0 0.48 11.0 8.0 1.6 1 0 0 1 1 1 0 Extracellular mutant protein 11 Mito_carr PF00153.27 EFW99249.1 - 8.2e-58 192.3 3.8 2.4e-24 85.1 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFW99249.1 - 0.00016 20.9 0.1 0.0016 17.6 0.0 2.5 3 1 1 4 4 4 1 Gammaproteobacterial serine protease NB-ARC PF00931.22 EFW99250.1 - 4.8e-18 65.2 0.0 7.8e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFW99250.1 - 1.2e-05 25.8 1.5 4.8e-05 23.8 0.4 2.6 2 1 0 2 2 2 1 AAA ATPase domain TPR_12 PF13424.6 EFW99250.1 - 2.5e-05 24.5 7.5 0.00043 20.5 0.0 4.7 5 1 1 6 6 6 1 Tetratricopeptide repeat Goodbye PF17109.5 EFW99250.1 - 0.00052 20.5 0.0 0.0017 18.8 0.0 2.0 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain TPR_MalT PF17874.1 EFW99250.1 - 0.0051 16.2 3.7 0.0087 15.5 1.2 2.4 2 1 0 2 2 2 1 MalT-like TPR region AAA_22 PF13401.6 EFW99250.1 - 0.018 15.3 0.0 0.058 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain TPR_8 PF13181.6 EFW99250.1 - 0.034 14.4 2.3 11 6.6 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFW99250.1 - 0.065 13.1 6.0 16 5.5 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFW99250.1 - 0.24 11.6 3.6 2.2e+02 2.4 0.3 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Pkinase PF00069.25 EFW99251.1 - 4e-51 173.9 0.0 6.6e-51 173.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99251.1 - 3.3e-18 65.9 0.0 5.6e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFW99251.1 - 0.21 11.5 0.9 0.33 10.8 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family SCA7 PF08313.12 EFW99252.1 - 2.8e-32 110.4 0.2 7.9e-32 109.0 0.2 1.8 1 0 0 1 1 1 1 SCA7, zinc-binding domain Treslin_N PF15292.6 EFW99254.1 - 0.17 10.2 0.2 0.21 9.9 0.2 1.1 1 0 0 1 1 1 0 Treslin N-terminus HAD_2 PF13419.6 EFW99255.1 - 1.3e-13 51.5 0.0 2e-12 47.6 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFW99255.1 - 7.2e-07 29.7 0.0 3.7e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFW99255.1 - 0.0058 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Aldedh PF00171.22 EFW99257.1 - 6.1e-71 239.3 0.0 1.1e-70 238.4 0.0 1.4 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_S4e PF00900.20 EFW99258.1 - 9.8e-37 124.7 0.1 2.4e-36 123.5 0.1 1.7 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EFW99258.1 - 6.3e-24 83.4 0.1 1.1e-23 82.5 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EFW99258.1 - 4.7e-17 61.8 5.6 9.5e-17 60.8 5.6 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 EFW99258.1 - 3.5e-05 23.6 2.7 3.8e-05 23.5 0.4 2.4 2 0 0 2 2 2 1 KOW motif S4 PF01479.25 EFW99258.1 - 0.001 18.8 0.0 0.0019 17.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain ComC PF03047.14 EFW99258.1 - 0.0074 16.0 0.1 0.018 14.8 0.1 1.5 1 0 0 1 1 1 1 COMC family Sipho_tail PF05709.11 EFW99258.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage tail protein MFS_1 PF07690.16 EFW99259.1 - 1e-52 179.2 17.0 1e-52 179.2 17.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW99259.1 - 2.7e-10 39.7 11.3 2.7e-10 39.7 11.3 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter Pyr_redox_2 PF07992.14 EFW99260.1 - 4.8e-38 131.1 0.0 6.6e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFW99260.1 - 4.9e-11 43.0 0.0 2.1e-09 37.8 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EFW99260.1 - 2.7e-06 26.5 0.1 5.7e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EFW99260.1 - 3.9e-05 23.2 0.3 0.00011 21.8 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EFW99260.1 - 0.00053 20.4 0.0 0.0013 19.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFW99260.1 - 0.0067 15.9 0.3 0.017 14.6 0.3 1.7 1 0 0 1 1 1 1 EF hand RRM_1 PF00076.22 EFW99262.1 - 2.4e-10 40.1 0.0 3.3e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFW99262.1 - 0.00034 20.6 0.0 0.00048 20.1 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif NOA36 PF06524.12 EFW99262.1 - 3.4 6.9 16.5 4.2 6.6 16.5 1.2 1 0 0 1 1 1 0 NOA36 protein F-box PF00646.33 EFW99263.1 - 2.3e-06 27.3 0.4 5.8e-06 26.0 0.4 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFW99263.1 - 0.0028 17.5 1.6 0.0098 15.8 0.4 2.4 2 0 0 2 2 2 1 F-box-like ApbA PF02558.16 EFW99264.1 - 3.5e-26 91.7 0.0 5.3e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EFW99264.1 - 1.3e-22 80.3 0.0 2e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF4336 PF14234.6 EFW99265.1 - 1.1e-16 60.9 0.0 2.2e-11 43.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4336) Coatomer_E PF04733.14 EFW99266.1 - 2.7e-56 191.1 8.3 3.1e-56 190.9 8.3 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EFW99266.1 - 1.1e-06 29.0 21.0 0.0042 17.6 4.7 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFW99266.1 - 1.3e-06 27.8 9.9 0.0001 21.7 1.3 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFW99266.1 - 4.9e-05 23.2 0.6 0.021 15.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFW99266.1 - 0.00016 21.9 0.3 0.44 10.8 0.3 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EFW99266.1 - 0.00047 20.1 8.6 0.0039 17.2 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFW99266.1 - 0.00085 19.9 0.9 0.00085 19.9 0.9 5.8 4 1 3 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFW99266.1 - 0.0013 19.2 4.0 0.17 12.6 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFW99266.1 - 0.0031 17.8 13.3 0.016 15.5 0.7 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFW99266.1 - 0.006 16.7 6.5 0.065 13.4 0.1 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFW99266.1 - 0.0094 16.6 1.2 0.0094 16.6 1.2 4.9 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFW99266.1 - 0.014 15.1 3.0 0.04 13.6 0.0 3.2 4 0 0 4 4 4 0 TPR repeat TPR_1 PF00515.28 EFW99266.1 - 0.047 13.5 1.2 2.9 7.9 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat NARP1 PF12569.8 EFW99266.1 - 0.077 11.9 3.3 1.7 7.5 0.2 2.3 1 1 0 2 2 2 0 NMDA receptor-regulated protein 1 P16-Arc PF04699.14 EFW99266.1 - 0.52 10.8 2.5 0.54 10.7 0.2 2.0 2 1 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) TPR_4 PF07721.14 EFW99266.1 - 0.57 11.0 31.1 0.75 10.6 1.4 6.0 6 1 0 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFW99266.1 - 2.8 8.5 4.5 9.7 6.8 0.2 4.0 4 2 0 4 4 4 0 Tetratricopeptide repeat ADH_N PF08240.12 EFW99267.1 - 1.9e-19 69.6 0.1 4.1e-19 68.5 0.0 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFW99267.1 - 1.1e-18 67.4 0.1 2e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFW99267.1 - 0.029 13.7 1.9 0.058 12.7 1.9 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GAF_2 PF13185.6 EFW99268.1 - 1.3e-05 25.5 0.1 3.2e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 EFW99268.1 - 0.0036 17.9 0.0 0.004 17.8 0.0 1.1 1 0 0 1 1 1 1 GAF domain NMD3 PF04981.13 EFW99269.1 - 6.6e-78 261.5 1.1 9.8e-78 261.0 1.1 1.3 1 0 0 1 1 1 1 NMD3 family GHMP_kinases_N PF00288.26 EFW99269.1 - 6.6e-15 55.1 3.9 2.5e-14 53.3 3.9 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFW99269.1 - 1e-07 32.2 0.0 2.6e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal TackOD1 PF18551.1 EFW99269.1 - 0.02 14.6 0.6 0.23 11.1 0.0 2.2 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 EFW99269.1 - 0.97 9.5 8.3 2.4 8.2 2.0 2.8 1 1 1 2 2 2 0 Double zinc ribbon FYVE PF01363.21 EFW99269.1 - 4.4 7.5 5.3 7.8 6.7 1.2 2.5 2 0 0 2 2 2 0 FYVE zinc finger RTA1 PF04479.13 EFW99270.1 - 0.0015 18.2 3.2 0.0027 17.4 3.2 1.3 1 0 0 1 1 1 1 RTA1 like protein Zn_clus PF00172.18 EFW99270.1 - 0.011 15.9 5.4 0.02 15.0 5.4 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Questin_oxidase PF14027.6 EFW99270.1 - 0.099 12.2 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Questin oxidase-like RNase_T PF00929.24 EFW99271.1 - 2.9e-16 60.4 0.0 4.3e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease adh_short PF00106.25 EFW99272.1 - 3.4e-21 75.6 0.0 5.6e-19 68.4 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW99272.1 - 6.7e-09 35.6 0.0 2.2e-08 33.9 0.0 1.7 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW99272.1 - 0.00014 21.8 0.0 0.00028 20.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Acyltransferase PF01553.21 EFW99273.1 - 1.3e-18 66.9 0.0 3.1e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Asp PF00026.23 EFW99274.1 - 7.4e-68 229.3 9.2 9.3e-68 229.0 9.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFW99274.1 - 2.8e-08 34.2 5.0 0.0013 19.0 0.1 3.1 1 1 3 4 4 4 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFW99274.1 - 6.6e-05 23.5 6.0 0.0038 17.8 1.8 3.4 2 1 0 2 2 2 2 Aspartyl protease Cytomega_UL20A PF05984.12 EFW99274.1 - 0.81 10.0 0.0 0.81 10.0 0.0 3.0 2 1 1 3 3 3 0 Cytomegalovirus UL20A protein Acyl_transf_3 PF01757.22 EFW99275.1 - 1.8e-32 112.8 15.4 2.7e-32 112.2 15.4 1.3 1 0 0 1 1 1 1 Acyltransferase family MFS_1 PF07690.16 EFW99276.1 - 1.4e-07 30.8 10.1 1.6e-07 30.6 10.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Pam17 PF08566.10 EFW99276.1 - 0.061 13.2 0.7 0.088 12.7 0.7 1.2 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Ribosomal_L17 PF01196.19 EFW99277.1 - 7.1e-35 119.8 0.1 1.4e-34 118.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L17 Mrpl_C PF18502.1 EFW99277.1 - 0.027 14.7 0.0 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain TAF4 PF05236.14 EFW99278.1 - 0.0016 18.3 6.0 0.0026 17.6 6.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Pex26 PF07163.12 EFW99278.1 - 0.0047 16.3 4.8 0.0047 16.3 4.8 2.1 1 1 1 2 2 2 1 Pex26 protein Plasmodium_Vir PF05795.11 EFW99278.1 - 0.14 11.5 1.3 0.24 10.8 1.3 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CDC45 PF02724.14 EFW99278.1 - 6.1 5.0 9.6 8.4 4.5 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein MARVEL PF01284.23 EFW99279.1 - 4e-22 78.8 11.5 4.6e-22 78.6 11.5 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF2304 PF10066.9 EFW99279.1 - 0.53 10.5 6.9 18 5.6 5.2 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) MpPF26 PF07666.11 EFW99279.1 - 5.1 7.2 9.6 41 4.3 6.4 2.4 2 1 0 2 2 2 0 M penetrans paralogue family 26 BTB PF00651.31 EFW99280.1 - 8.2e-25 87.2 0.0 3.4e-12 46.6 0.1 3.4 3 0 0 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 EFW99280.1 - 5.3e-06 26.9 0.0 1.7e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFW99280.1 - 7.9e-06 26.4 0.0 2.3e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFW99280.1 - 9e-06 25.9 0.0 3.2e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFW99280.1 - 0.00039 20.7 0.2 0.0029 18.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EFW99280.1 - 0.015 15.7 0.2 0.11 13.1 0.0 2.6 3 0 0 3 3 3 0 Ankyrin repeat DUF3342 PF11822.8 EFW99280.1 - 0.094 12.9 0.0 0.65 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Mt_ATP-synt_D PF05873.12 EFW99281.1 - 6.1e-21 74.9 1.2 7.3e-21 74.6 1.2 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Dor1 PF04124.12 EFW99281.1 - 0.052 12.2 0.8 0.065 11.9 0.8 1.1 1 0 0 1 1 1 0 Dor1-like family E3_UbLigase_R4 PF13764.6 EFW99281.1 - 0.11 10.6 0.2 0.13 10.4 0.2 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 RasGAP_C PF03836.15 EFW99281.1 - 0.12 12.5 0.2 0.33 11.1 0.0 1.7 2 0 0 2 2 2 0 RasGAP C-terminus DUF327 PF03885.13 EFW99281.1 - 0.13 12.2 0.9 0.47 10.4 0.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF327) MFS_1 PF07690.16 EFW99282.1 - 4.1e-30 104.9 34.0 4.9e-24 84.9 7.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW99282.1 - 2.5e-06 26.6 6.6 2.5e-06 26.6 6.6 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFW99282.1 - 0.0054 15.2 1.2 0.0088 14.5 1.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ceramidase PF05875.12 EFW99283.1 - 1.1e-65 221.7 12.6 1.5e-65 221.3 12.6 1.1 1 0 0 1 1 1 1 Ceramidase DUF3488 PF11992.8 EFW99283.1 - 0.025 13.5 5.2 0.012 14.6 3.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3488) Ribosomal_L18 PF17135.4 EFW99284.1 - 1.4e-92 308.2 4.2 1.6e-92 308.1 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EFW99284.1 - 0.007 17.0 0.1 0.007 17.0 0.1 2.0 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Adap_comp_sub PF00928.21 EFW99285.1 - 1.3e-59 201.7 0.0 2e-59 201.1 0.0 1.3 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Pol_alpha_B_N PF08418.10 EFW99285.1 - 0.51 10.3 4.2 15 5.4 3.6 2.1 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF3464 PF11947.8 EFW99285.1 - 0.63 9.8 3.9 1 9.1 3.9 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4554 PF15091.6 EFW99285.1 - 7.1 5.4 4.8 11 4.7 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) But2 PF09792.9 EFW99286.1 - 4e-05 24.0 0.0 8.5e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Cyclase PF04199.13 EFW99287.1 - 8e-14 52.0 0.0 2.1e-13 50.7 0.0 1.6 1 1 1 2 2 2 1 Putative cyclase UPF0047 PF01894.17 EFW99288.1 - 5e-36 123.3 0.0 5.6e-36 123.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 FtsJ PF01728.19 EFW99289.1 - 9e-56 188.8 0.0 1.1e-55 188.5 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EFW99289.1 - 0.00026 20.8 0.0 0.00047 20.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99289.1 - 0.072 12.9 0.0 7.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain rRNA_methylase PF06962.12 EFW99289.1 - 0.16 12.0 0.0 0.75 9.8 0.0 1.9 2 0 0 2 2 2 0 Putative rRNA methylase Methyltransf_25 PF13649.6 EFW99289.1 - 0.16 12.7 0.0 1.7 9.4 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain DEAD PF00270.29 EFW99290.1 - 1.9e-41 141.8 0.0 3.3e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW99290.1 - 1.2e-18 67.4 0.0 4e-18 65.8 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFW99290.1 - 3.3e-15 56.0 0.0 7.6e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFW99290.1 - 3.3e-05 24.0 0.0 7.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFW99291.1 - 0.0062 16.8 0.3 0.063 13.5 0.1 2.6 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 EFW99291.1 - 0.0065 15.9 0.0 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Bacterial TniB protein AAA_16 PF13191.6 EFW99291.1 - 0.014 15.8 0.0 0.038 14.4 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EFW99291.1 - 0.12 12.8 0.1 1.4 9.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFW99291.1 - 0.17 11.6 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTF2 PF02136.20 EFW99292.1 - 8.5e-26 90.9 0.3 1.3e-25 90.3 0.3 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EFW99292.1 - 2.4e-07 30.4 0.0 4.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFW99292.1 - 0.02 14.9 0.0 0.08 13.0 0.0 2.0 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif NAC PF01849.18 EFW99293.1 - 2.4e-21 75.5 0.1 4.5e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 NAC domain SelP_N PF04592.14 EFW99293.1 - 0.7 9.2 18.6 0.034 13.6 12.7 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region JAB PF01398.21 EFW99295.1 - 3e-18 65.9 0.0 4.4e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFW99295.1 - 1.4e-10 41.6 0.0 3.8e-10 40.2 0.0 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EFW99295.1 - 0.17 11.9 0.0 0.44 10.6 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) NIR_SIR PF01077.22 EFW99296.1 - 2.2e-52 176.8 0.0 1.1e-46 158.3 0.0 2.5 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EFW99296.1 - 7.5e-29 99.4 0.0 4.2e-14 52.1 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EFW99296.1 - 1.1e-28 100.2 0.0 2.7e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EFW99296.1 - 2.7e-08 33.8 0.3 6.1e-08 32.7 0.3 1.6 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Flavodoxin_5 PF12724.7 EFW99296.1 - 0.045 14.0 0.0 0.17 12.1 0.0 2.0 2 0 0 2 2 2 0 Flavodoxin domain Glyco_hydro_35 PF01301.19 EFW99297.1 - 9e-78 262.1 2.6 1.4e-77 261.4 2.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EFW99297.1 - 1.2e-56 190.1 0.2 2.6e-30 105.3 0.0 2.8 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EFW99297.1 - 1.3e-47 161.9 4.0 3.1e-47 160.7 4.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EFW99297.1 - 5.8e-21 73.9 0.0 1.4e-20 72.6 0.0 1.7 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 Cellulase PF00150.18 EFW99297.1 - 0.0042 16.6 0.2 0.053 12.9 0.0 2.5 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) RVP PF00077.20 EFW99297.1 - 0.073 13.4 0.1 0.44 10.9 0.0 2.1 2 0 0 2 2 2 0 Retroviral aspartyl protease SARAF PF06682.12 EFW99299.1 - 2.6e-72 244.3 10.7 4e-36 125.3 7.0 2.0 2 0 0 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis DUF155 PF02582.14 EFW99300.1 - 7.6e-54 182.5 0.0 1.3e-53 181.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 E1-E2_ATPase PF00122.20 EFW99300.1 - 1.9e-49 167.6 0.5 1.9e-49 167.6 0.5 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EFW99300.1 - 6.5e-48 161.0 2.9 2.3e-13 50.4 0.1 4.6 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EFW99300.1 - 9.2e-39 133.9 4.4 2.6e-38 132.4 4.4 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFW99300.1 - 6.4e-06 26.1 1.4 2.9e-05 23.9 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFW99300.1 - 0.0082 16.6 1.6 0.0098 16.3 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DSBA PF01323.20 EFW99300.1 - 0.14 11.9 3.6 3.9 7.2 0.0 3.6 3 0 0 3 3 3 0 DSBA-like thioredoxin domain CcmF_C PF16327.5 EFW99300.1 - 1.6 8.0 8.8 0.51 9.6 4.3 2.4 2 0 0 2 2 2 0 Cytochrome c-type biogenesis protein CcmF C-terminal RRM_1 PF00076.22 EFW99301.1 - 3.1e-07 30.1 0.0 3e-05 23.7 0.0 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MWFE PF15879.5 EFW99301.1 - 0.032 14.4 0.3 0.097 12.9 0.0 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Mg_trans_NIPA PF05653.14 EFW99302.1 - 2.9e-16 59.5 11.7 7.9e-16 58.0 11.7 1.6 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EFW99302.1 - 9.4e-05 22.6 14.0 0.0003 21.0 0.2 2.7 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 EFW99302.1 - 0.0023 17.2 8.6 0.0065 15.7 8.5 1.9 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport Robl_LC7 PF03259.17 EFW99303.1 - 3.4e-07 29.9 0.0 8.5e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Roadblock/LC7 domain Apolipoprotein PF01442.18 EFW99304.1 - 0.0063 16.4 26.8 0.0063 16.4 26.8 3.0 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain Nuc_N PF14448.6 EFW99304.1 - 0.008 16.0 1.8 0.023 14.5 0.7 2.4 1 1 1 2 2 2 1 Nuclease N terminal NPV_P10 PF05531.12 EFW99304.1 - 2.1 8.9 23.8 0.21 12.1 0.6 5.0 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein HOOK PF05622.12 EFW99304.1 - 5.5 5.0 59.3 0.062 11.4 6.9 3.1 1 1 2 3 3 3 0 HOOK protein CAF1 PF04857.20 EFW99305.1 - 4e-22 78.8 0.0 2.3e-10 40.1 0.0 2.1 2 0 0 2 2 2 2 CAF1 family ribonuclease RFX_DNA_binding PF02257.15 EFW99305.1 - 0.14 12.8 0.0 0.4 11.3 0.0 1.7 2 0 0 2 2 2 0 RFX DNA-binding domain dsDNA_bind PF01984.20 EFW99307.1 - 8.4e-32 109.7 19.4 8.4e-32 109.7 19.4 2.8 2 0 0 2 2 2 1 Double-stranded DNA-binding domain ApbA_C PF08546.11 EFW99307.1 - 2.2e-16 60.2 0.0 5.6e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFW99307.1 - 3e-11 43.2 0.0 9.6e-11 41.6 0.0 1.9 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Fes1 PF08609.10 EFW99307.1 - 0.11 13.4 3.1 2.2 9.2 3.2 2.9 2 1 0 2 2 2 0 Nucleotide exchange factor Fes1 CDT1_C PF16679.5 EFW99307.1 - 0.29 11.6 6.6 1.3 9.5 6.6 2.2 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Aldo_ket_red PF00248.21 EFW99308.1 - 3.4e-51 174.2 0.0 5.1e-50 170.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Glu_cyclase_2 PF05096.12 EFW99308.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Glutamine cyclotransferase HET PF06985.11 EFW99310.1 - 9e-28 97.5 1.4 1.5e-27 96.8 1.4 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Zn_clus PF00172.18 EFW99311.1 - 1.1e-07 31.8 8.7 1.1e-07 31.8 8.7 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFW99311.1 - 9.4e-06 24.7 0.2 1.4e-05 24.1 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain AnmK PF03702.14 EFW99312.1 - 4.9e-85 285.8 0.0 5.7e-85 285.6 0.0 1.0 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase WD40 PF00400.32 EFW99313.1 - 4.6e-18 65.2 14.8 0.00014 22.6 0.0 7.5 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99313.1 - 1.6e-15 57.1 0.1 4.3e-05 23.7 0.0 5.4 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFW99313.1 - 3.3e-06 27.1 0.3 0.018 15.0 0.0 3.3 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 EFW99313.1 - 0.0014 17.7 0.0 0.74 8.8 0.0 3.0 2 1 1 3 3 3 1 Coatomer WD associated region PD40 PF07676.12 EFW99313.1 - 0.0065 16.4 3.2 9.6 6.3 0.3 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EFW99313.1 - 0.067 12.1 0.0 25 3.7 0.0 3.4 2 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein A_deaminase PF00962.22 EFW99314.1 - 1.8e-27 96.6 0.0 2.8e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Acyltransferase PF01553.21 EFW99315.1 - 5.4e-05 22.8 0.0 0.00016 21.3 0.0 1.8 1 1 0 1 1 1 1 Acyltransferase Ank_2 PF12796.7 EFW99316.1 - 2.6e-42 143.3 0.1 8.5e-14 51.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFW99316.1 - 1.8e-29 100.8 0.0 0.00078 19.8 0.0 6.1 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 EFW99316.1 - 1.9e-28 95.3 0.0 0.00085 19.6 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFW99316.1 - 8.8e-27 92.8 7.3 7.8e-07 29.3 0.1 4.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFW99316.1 - 1.2e-26 92.8 0.2 2.5e-06 27.9 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) TFR_dimer PF04253.15 EFW99317.1 - 3.2e-29 101.5 0.0 5.9e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EFW99317.1 - 3.1e-19 69.4 0.0 5.2e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFW99317.1 - 4.3e-11 42.7 0.1 1.2e-10 41.3 0.1 1.8 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 EFW99317.1 - 0.094 12.2 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Nicastrin APG6_N PF17675.1 EFW99318.1 - 2.7 8.5 7.5 1.6 9.3 1.4 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region N2227 PF07942.12 EFW99319.1 - 1.6e-55 188.3 0.0 2.1e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 EFW99319.1 - 2e-09 38.0 0.1 1.4e-07 32.0 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW99319.1 - 5.8e-07 30.1 0.1 4.5e-05 24.1 0.0 2.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99319.1 - 3e-05 24.7 0.0 0.00012 22.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW99319.1 - 0.00013 21.8 0.0 0.00028 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99319.1 - 0.013 15.3 0.1 0.095 12.5 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 EFW99319.1 - 0.025 15.6 0.1 0.11 13.5 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_8 PF05148.15 EFW99319.1 - 0.029 14.2 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.17 EFW99319.1 - 0.043 13.0 0.0 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Sulfatase PF00884.23 EFW99320.1 - 6.7e-55 186.6 0.0 9.1e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Med8 PF10232.9 EFW99320.1 - 7.9e-27 94.3 4.0 2.4e-26 92.8 4.1 1.6 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Choline_sulf_C PF12411.8 EFW99320.1 - 1.2e-25 89.1 1.6 2.4e-25 88.1 0.9 2.0 2 0 0 2 2 2 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EFW99320.1 - 8.5e-06 25.6 0.0 0.032 13.8 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Nop14 PF04147.12 EFW99320.1 - 0.082 11.1 3.3 0.11 10.7 3.3 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 EFW99320.1 - 0.23 11.9 11.0 0.5 10.8 11.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PTPRCAP PF15713.5 EFW99320.1 - 0.5 10.6 4.6 1.2 9.4 4.6 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated FAM176 PF14851.6 EFW99320.1 - 1.2 8.8 5.0 4 7.1 5.2 1.7 2 0 0 2 2 2 0 FAM176 family PBP1_TM PF14812.6 EFW99320.1 - 2.6 8.5 9.9 1.3 9.5 7.3 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 EFW99320.1 - 4.8 7.2 6.2 9.1 6.3 6.2 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DDOST_48kD PF03345.14 EFW99321.1 - 1.5e-149 498.4 0.0 2.2e-149 497.8 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Beach PF02138.18 EFW99321.1 - 8.9e-119 395.9 0.0 1.3e-118 395.4 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EFW99321.1 - 1e-12 48.0 0.0 3.4e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EFW99321.1 - 3.7e-11 43.4 0.0 8.6e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 EFW99321.1 - 0.0064 17.3 4.8 1.6 9.7 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF4637 PF15470.6 EFW99321.1 - 5.8 6.6 7.4 20 4.9 7.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PTPRCAP PF15713.5 EFW99321.1 - 6.3 7.1 12.8 31 4.8 12.8 2.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SDA1 PF05285.12 EFW99321.1 - 9.1 5.6 15.4 19 4.6 15.4 1.4 1 0 0 1 1 1 0 SDA1 Spc7_N PF15402.6 EFW99322.1 - 2e-163 546.0 135.8 8e-117 391.8 82.1 5.4 2 1 2 4 4 4 3 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 EFW99322.1 - 2.7e-101 338.6 10.0 2.7e-101 338.6 10.0 1.7 2 0 0 2 2 2 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 EFW99322.1 - 4.5e-18 65.1 0.6 9.4e-18 64.1 0.6 1.6 1 0 0 1 1 1 1 Spc7_C2 Sipho_Gp157 PF05565.11 EFW99322.1 - 0.34 10.9 7.4 2 8.4 7.4 2.3 1 0 0 1 1 1 0 Siphovirus Gp157 GAS PF13851.6 EFW99322.1 - 5.3 6.3 19.9 0.081 12.3 5.0 3.0 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Sugar_tr PF00083.24 EFW99323.1 - 2.6e-88 296.9 19.0 3e-88 296.7 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFW99323.1 - 1.7e-31 109.5 44.9 1.8e-26 92.9 24.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Keratin_assoc PF09775.9 EFW99323.1 - 0.062 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Keratinocyte-associated protein 2 Claudin_2 PF13903.6 EFW99323.1 - 0.16 11.7 0.1 0.16 11.7 0.1 3.3 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction OATP PF03137.20 EFW99323.1 - 6.1 5.0 9.9 0.43 8.8 3.7 2.1 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3792 PF12670.7 EFW99323.1 - 9.4 6.4 24.9 1.5 9.0 9.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) FCH PF00611.23 EFW99324.1 - 1.7e-25 89.1 0.2 1.7e-25 89.1 0.2 3.0 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 EFW99324.1 - 5.7e-23 80.5 0.6 1.2e-12 47.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 EFW99324.1 - 2.7e-15 56.0 5.6 4.1e-15 55.4 5.6 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.28 EFW99324.1 - 1.7e-13 49.9 0.1 4.8e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_3 PF08239.11 EFW99324.1 - 0.00011 22.4 0.5 0.012 15.9 0.1 2.5 2 0 0 2 2 2 1 Bacterial SH3 domain C1_2 PF03107.16 EFW99324.1 - 0.01 16.2 4.8 0.017 15.4 4.8 1.3 1 0 0 1 1 1 0 C1 domain SH3_2 PF07653.17 EFW99324.1 - 0.02 14.6 0.0 0.89 9.3 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain SH3_10 PF17902.1 EFW99324.1 - 0.025 14.6 0.1 0.41 10.7 0.0 3.0 4 0 0 4 4 4 0 SH3 domain Spc7 PF08317.11 EFW99324.1 - 0.036 13.0 13.5 0.09 11.6 3.5 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein Allexi_40kDa PF05549.11 EFW99324.1 - 0.16 11.4 3.7 0.13 11.8 0.3 2.3 2 1 1 3 3 3 0 Allexivirus 40kDa protein FYVE PF01363.21 EFW99324.1 - 0.49 10.6 4.3 1 9.6 4.3 1.4 1 0 0 1 1 1 0 FYVE zinc finger Ins_P5_2-kin PF06090.12 EFW99325.1 - 2.8e-48 165.1 0.0 3.3e-48 164.8 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Fungal_trans_2 PF11951.8 EFW99326.1 - 7.6e-10 38.2 0.1 1.7e-09 37.0 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF5437 PF17505.2 EFW99326.1 - 0.14 12.2 0.1 9 6.4 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5437) MRP-S28 PF10213.9 EFW99327.1 - 3.3e-46 156.8 0.0 5.3e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein LTXXQ PF07813.12 EFW99327.1 - 0.00047 20.8 8.3 1.1 10.0 0.0 3.5 3 0 0 3 3 3 2 LTXXQ motif family protein DpnI_C PF17726.1 EFW99327.1 - 0.18 11.9 0.3 0.45 10.7 0.1 1.7 2 0 0 2 2 2 0 Dam-replacing HTH domain Fibrinogen_BP PF08017.11 EFW99328.1 - 6e-07 28.2 0.6 7.3e-07 28.0 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen binding protein S_100 PF01023.19 EFW99328.1 - 0.12 12.1 14.3 32 4.3 0.1 5.5 5 1 1 6 6 6 0 S-100/ICaBP type calcium binding domain Aminotran_5 PF00266.19 EFW99329.1 - 1e-91 307.7 0.0 1.3e-91 307.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFW99329.1 - 6e-07 29.0 0.0 6.8e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EFW99329.1 - 2.6e-05 23.7 0.3 9.1e-05 21.9 0.4 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Ras PF00071.22 EFW99330.1 - 1.1e-48 164.8 0.1 1.4e-48 164.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFW99330.1 - 5.7e-26 91.1 0.1 9.3e-26 90.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFW99330.1 - 5.8e-12 45.4 0.3 6.9e-12 45.2 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFW99330.1 - 3.9e-06 26.5 0.1 7.5e-06 25.6 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFW99330.1 - 0.016 14.6 0.1 0.02 14.3 0.1 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EFW99330.1 - 0.022 14.6 0.0 0.026 14.3 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein TIR_2 PF13676.6 EFW99330.1 - 0.024 15.2 0.1 0.042 14.5 0.1 1.4 1 0 0 1 1 1 0 TIR domain FlgH PF02107.16 EFW99330.1 - 0.028 14.0 0.3 0.037 13.6 0.3 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein TetR_C_16 PF17920.1 EFW99330.1 - 0.028 14.6 0.0 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF1907 PF08925.11 EFW99331.1 - 1.4e-100 336.4 0.0 1.6e-100 336.2 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) SANT_DAMP1_like PF16282.5 EFW99332.1 - 2.7e-30 104.4 0.0 4.8e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 EFW99332.1 - 0.014 15.3 0.8 0.014 15.3 0.8 3.5 3 1 1 4 4 4 0 DNA methyltransferase 1-associated protein 1 (DMAP1) FTA4 PF13093.6 EFW99332.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Myb_DNA-bind_6 PF13921.6 EFW99332.1 - 0.14 12.4 0.0 0.57 10.5 0.0 2.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain PCI PF01399.27 EFW99333.1 - 0.0018 18.7 0.0 0.0033 17.9 0.0 1.4 1 1 0 1 1 1 1 PCI domain DinB_2 PF12867.7 EFW99333.1 - 0.076 13.5 0.3 0.14 12.6 0.3 1.5 1 0 0 1 1 1 0 DinB superfamily CSN7a_helixI PF18392.1 EFW99333.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain TraG_N PF07916.11 EFW99333.1 - 0.17 10.7 1.7 0.28 10.0 1.7 1.3 1 0 0 1 1 1 0 TraG-like protein, N-terminal region DUF1687 PF07955.11 EFW99334.1 - 2.1e-33 115.5 0.1 2.6e-33 115.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) Herpes_DNAp_acc PF04929.12 EFW99334.1 - 0.034 13.1 0.2 0.038 13.0 0.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Pkinase PF00069.25 EFW99335.1 - 2e-58 197.8 0.0 2.8e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99335.1 - 4.6e-26 91.7 0.0 6.6e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFW99335.1 - 7.4e-05 22.2 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFW99335.1 - 0.0094 15.9 5.2 0.32 10.9 0.0 3.2 4 0 0 4 4 4 2 Phosphotransferase enzyme family Kdo PF06293.14 EFW99335.1 - 0.053 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acatn PF13000.7 EFW99336.1 - 9.4e-134 446.9 17.2 3.1e-52 177.8 0.8 4.2 1 1 3 4 4 4 4 Acetyl-coenzyme A transporter 1 MFS_1_like PF12832.7 EFW99336.1 - 0.55 9.0 11.3 1.1 8.0 11.3 1.4 1 0 0 1 1 1 0 MFS_1 like family FACT-Spt16_Nlob PF14826.6 EFW99337.1 - 3.5e-55 186.2 0.2 3.5e-55 186.2 0.2 2.3 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.11 EFW99337.1 - 3.3e-54 183.2 0.0 3.3e-54 183.2 0.0 3.2 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 EFW99337.1 - 4e-27 95.3 0.0 7.1e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EFW99337.1 - 4.5e-15 55.8 1.4 9e-15 54.9 0.1 2.2 3 0 0 3 3 3 1 Histone chaperone Rttp106-like Arylsulfotran_2 PF14269.6 EFW99338.1 - 2.1e-43 148.8 0.0 3.2e-43 148.2 0.0 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EFW99338.1 - 1e-11 44.4 0.1 1.6e-11 43.8 0.1 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Cwf_Cwc_15 PF04889.12 EFW99339.1 - 0.014 15.1 13.1 2.7 7.6 0.1 2.3 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Sulfotransfer_4 PF17784.1 EFW99340.1 - 1.4e-60 204.8 0.2 1.6e-60 204.6 0.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EFW99340.1 - 0.00082 19.8 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family TauD PF02668.16 EFW99341.1 - 3.7e-61 207.3 1.3 4.7e-61 206.9 1.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family BRE1 PF08647.11 EFW99342.1 - 9.9e-29 99.3 9.3 9.9e-29 99.3 9.3 6.0 5 1 1 6 6 5 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.6 EFW99342.1 - 1.4e-09 37.6 8.3 2.5e-09 36.8 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFW99342.1 - 6.9e-09 35.4 7.8 1.2e-08 34.7 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFW99342.1 - 8.1e-09 35.4 5.1 1.7e-08 34.3 5.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFW99342.1 - 2.1e-08 33.9 7.4 3.6e-08 33.1 7.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFW99342.1 - 2.7e-08 33.6 9.8 5e-08 32.8 9.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFW99342.1 - 1.7e-07 31.0 9.8 3.2e-07 30.1 9.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFW99342.1 - 2.4e-07 31.0 8.3 4.2e-07 30.2 8.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFW99342.1 - 0.0002 21.5 6.9 0.00045 20.3 6.9 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EFW99342.1 - 0.0063 16.8 7.4 0.031 14.6 7.4 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain JIP_LZII PF16471.5 EFW99342.1 - 0.017 15.3 2.3 0.017 15.3 2.3 7.0 7 2 3 10 10 9 0 JNK-interacting protein leucine zipper II zf-C2H2_jaz PF12171.8 EFW99342.1 - 0.092 13.1 4.3 0.52 10.7 0.1 3.2 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding HypA PF01155.19 EFW99342.1 - 0.094 12.7 4.3 0.38 10.8 4.3 2.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1272 PF06906.11 EFW99342.1 - 0.12 12.5 5.0 0.25 11.5 5.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 EFW99342.1 - 0.14 12.0 6.9 0.93 9.3 7.3 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EFW99342.1 - 0.14 12.0 3.0 0.33 10.9 3.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein GIT_CC PF16559.5 EFW99342.1 - 0.16 11.8 0.1 0.16 11.8 0.1 5.6 6 0 0 6 6 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-C2H2_6 PF13912.6 EFW99342.1 - 0.18 11.9 1.2 0.47 10.5 0.0 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-UDP PF14569.6 EFW99342.1 - 0.18 11.9 4.0 0.5 10.5 4.0 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Vac_Fusion PF02346.16 EFW99342.1 - 0.37 10.5 10.0 7.8 6.2 0.0 5.2 6 0 0 6 6 5 0 Chordopoxvirus multifunctional envelope protein A27 zf-Nse PF11789.8 EFW99342.1 - 0.61 10.0 4.5 1.3 8.9 4.5 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PLAC9 PF15205.6 EFW99342.1 - 0.9 10.0 2.6 2 8.8 0.2 2.8 3 0 0 3 3 2 0 Placenta-specific protein 9 Zn_ribbon_17 PF17120.5 EFW99342.1 - 0.91 9.2 4.5 1.7 8.3 4.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_10 PF16685.5 EFW99342.1 - 0.97 9.6 5.7 2.2 8.5 5.7 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 EFW99342.1 - 1.1 9.1 6.3 2.6 7.9 6.3 1.7 1 0 0 1 1 1 0 RING-like zinc finger FYVE PF01363.21 EFW99342.1 - 2.7 8.2 11.3 34 4.7 11.4 2.4 1 1 1 2 2 2 0 FYVE zinc finger FCH PF00611.23 EFW99343.1 - 3e-14 53.0 1.2 6e-14 52.1 0.0 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EFW99343.1 - 1.7e-13 49.9 0.0 3.5e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFW99343.1 - 7.1e-12 44.8 0.0 3.8e-11 42.5 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EFW99343.1 - 1.1e-10 41.2 0.1 2e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain ApoLp-III PF07464.11 EFW99343.1 - 5.4 7.1 12.4 12 6.0 1.3 3.3 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Pkinase PF00069.25 EFW99344.1 - 1.1e-74 251.2 0.0 1.4e-74 250.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99344.1 - 3.3e-35 121.6 0.0 5.3e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFW99344.1 - 0.027 13.4 0.0 0.51 9.2 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain PHF5 PF03660.14 EFW99345.1 - 8.1e-53 177.0 9.7 9.2e-53 176.8 9.7 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EFW99345.1 - 0.3 8.9 6.4 0.32 8.8 6.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EFW99345.1 - 2.4 8.3 15.7 6 7.0 2.1 3.0 1 1 1 2 2 2 0 Double zinc ribbon tRNA-synt_1 PF00133.22 EFW99346.1 - 4.3e-201 669.3 0.0 5.5e-201 668.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFW99346.1 - 1.2e-24 87.0 0.0 2.8e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFW99346.1 - 4.9e-16 58.5 1.0 2.7e-06 26.4 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFW99346.1 - 0.0019 17.6 0.0 0.022 14.1 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain WD40 PF00400.32 EFW99347.1 - 8.4e-27 92.9 35.5 0.00053 20.7 0.0 10.9 11 1 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99347.1 - 8.5e-13 48.4 3.4 0.0042 17.3 0.1 6.1 3 3 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFW99347.1 - 0.00088 19.1 0.8 1.8 8.6 0.0 4.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EFW99347.1 - 0.012 14.3 0.1 0.17 10.5 0.0 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFW99347.1 - 0.038 12.9 6.9 10 5.0 0.1 5.1 5 1 1 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EFW99347.1 - 0.054 14.0 21.1 2.1 8.9 0.3 7.2 6 2 3 9 9 9 0 PQQ-like domain NHL PF01436.21 EFW99347.1 - 0.063 13.3 0.7 0.5 10.5 0.1 3.1 2 0 0 2 2 2 0 NHL repeat DUF1077 PF06417.12 EFW99348.1 - 2.3e-48 163.1 3.5 2.9e-48 162.8 3.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) NUDIX_2 PF13869.6 EFW99349.1 - 3.8e-80 267.9 0.0 4.5e-80 267.7 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase F-box PF00646.33 EFW99350.1 - 7.9e-06 25.6 0.3 1.7e-05 24.6 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFW99350.1 - 9.7e-06 25.4 0.1 1.7e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFW99350.1 - 0.12 12.3 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 F-box cwf18 PF08315.12 EFW99352.1 - 1e-44 152.5 2.6 1e-44 152.5 2.6 1.9 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor Abhydrolase_3 PF07859.13 EFW99354.1 - 4.1e-28 98.7 0.0 6.9e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFW99354.1 - 0.00057 19.2 0.0 0.0022 17.3 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 GREB1 PF15782.5 EFW99355.1 - 4.2 4.4 7.0 5 4.1 7.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TPR_2 PF07719.17 EFW99356.1 - 0.00021 21.1 11.6 0.017 15.2 1.2 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFW99356.1 - 0.00032 20.9 8.7 0.0011 19.3 8.4 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFW99356.1 - 0.00033 20.3 5.7 0.27 11.1 0.4 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFW99356.1 - 0.0074 16.2 4.5 0.14 12.3 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFW99356.1 - 0.07 13.8 5.1 38 5.2 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3138 PF11336.8 EFW99356.1 - 0.43 9.1 4.9 0.9 8.1 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TRAP_alpha PF03896.16 EFW99356.1 - 3.3 6.8 6.0 1.5 8.0 1.3 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit TPR_14 PF13428.6 EFW99356.1 - 6.2 7.9 16.0 0.84 10.6 1.4 3.8 2 2 1 3 3 3 0 Tetratricopeptide repeat PS_Dcarbxylase PF02666.15 EFW99357.1 - 8.3e-58 195.2 0.0 1.2e-57 194.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EFW99357.1 - 5.9e-39 132.5 0.0 5.6e-19 68.3 0.0 2.4 2 0 0 2 2 2 2 C2 domain EF-hand_1 PF00036.32 EFW99357.1 - 0.0024 17.3 0.0 0.007 15.8 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EFW99357.1 - 0.0097 15.4 0.0 0.033 13.7 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EFW99357.1 - 0.023 15.2 0.1 0.072 13.6 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EFW99357.1 - 0.034 14.1 0.7 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain PBP1_TM PF14812.6 EFW99357.1 - 0.2 12.0 3.4 0.64 10.4 3.4 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GCS PF03074.16 EFW99358.1 - 4.7e-171 569.1 0.0 2.3e-170 566.8 0.0 1.9 1 1 0 1 1 1 1 Glutamate-cysteine ligase SCP2 PF02036.17 EFW99359.1 - 1.7e-21 76.6 1.2 1.9e-21 76.4 1.2 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EFW99359.1 - 0.00031 21.0 0.1 0.00046 20.5 0.1 1.4 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 EFW99359.1 - 0.0034 17.8 0.1 0.0043 17.4 0.1 1.2 1 0 0 1 1 1 1 Sterol carrier protein domain Scm3 PF10384.9 EFW99360.1 - 7.4e-17 60.8 0.0 2e-16 59.4 0.0 1.8 1 0 0 1 1 1 1 Centromere protein Scm3 FAD_binding_4 PF01565.23 EFW99361.1 - 2.6e-22 79.1 2.4 5e-22 78.1 2.4 1.5 1 0 0 1 1 1 1 FAD binding domain Seipin PF06775.14 EFW99362.1 - 3.9e-50 170.7 0.0 5.1e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) tRNA_synthFbeta PF17759.1 EFW99363.1 - 2.6e-40 138.2 0.0 4.2e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EFW99363.1 - 8.3e-25 86.8 0.1 2.7e-24 85.2 0.0 1.9 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EFW99363.1 - 1.6e-24 86.5 0.1 3.1e-24 85.6 0.1 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EFW99363.1 - 4.3e-15 55.8 0.0 2e-14 53.6 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetase B5 domain MFS_2 PF13347.6 EFW99363.1 - 0.0095 14.5 4.8 0.026 13.1 0.1 2.8 2 1 1 3 3 3 1 MFS/sugar transport protein Polysacc_deac_3 PF15421.6 EFW99363.1 - 0.17 10.3 0.0 0.28 9.7 0.0 1.2 1 0 0 1 1 1 0 Putative polysaccharide deacetylase Rad60-SLD_2 PF13881.6 EFW99364.1 - 1.3e-11 44.5 0.1 3.1e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFW99364.1 - 0.00075 19.2 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EFW99364.1 - 0.0014 19.2 0.1 0.0036 17.8 0.0 1.7 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ER_lumen_recept PF00810.18 EFW99367.1 - 1.6e-41 142.5 10.4 2.7e-41 141.8 10.4 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor Sec1 PF00995.23 EFW99368.1 - 5.5e-126 422.1 0.0 6.3e-126 421.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Peptidase_S8 PF00082.22 EFW99369.1 - 2.7e-34 118.8 4.3 4.1e-34 118.2 4.3 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EFW99369.1 - 4.2e-19 69.0 0.0 7.6e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Ipi1_N PF12333.8 EFW99370.1 - 3.4e-24 85.4 0.0 1.1e-23 83.8 0.0 1.9 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Tetraspanin PF00335.20 EFW99373.1 - 0.002 17.9 10.3 0.0044 16.8 10.3 1.5 1 1 0 1 1 1 1 Tetraspanin family DEAD PF00270.29 EFW99374.1 - 6.8e-33 113.9 0.1 1.6e-32 112.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW99374.1 - 8.2e-25 87.3 0.0 1.7e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99374.1 - 4.6e-05 23.5 0.0 8.7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFW99374.1 - 0.0014 18.4 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFW99374.1 - 0.031 14.5 0.9 1.2 9.4 0.5 2.8 2 1 0 2 2 2 0 AAA domain Chitin_synth_1 PF01644.17 EFW99376.1 - 4.9e-76 254.2 0.1 7e-76 253.7 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EFW99376.1 - 2.4e-27 94.7 0.1 5.3e-27 93.6 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EFW99376.1 - 3.5e-21 75.4 5.2 2.5e-19 69.3 0.0 2.3 1 1 1 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EFW99376.1 - 5.3e-08 33.0 0.7 5.3e-08 33.0 0.7 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Nucleoside_tran PF01733.18 EFW99377.1 - 4.7e-29 101.8 29.4 9.2e-22 77.8 2.6 4.0 4 1 0 4 4 4 3 Nucleoside transporter Pinin_SDK_memA PF04696.13 EFW99377.1 - 6.2e-29 100.7 17.2 6.2e-29 100.7 17.2 2.8 4 0 0 4 4 4 1 pinin/SDK/memA/ protein conserved region COesterase PF00135.28 EFW99378.1 - 1.5e-84 284.7 0.0 1.7e-84 284.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFW99378.1 - 3.8e-05 23.6 0.1 9.5e-05 22.3 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold MARVEL PF01284.23 EFW99379.1 - 5.5e-10 39.4 14.7 5.7e-09 36.1 14.6 2.0 1 1 1 2 2 2 1 Membrane-associating domain Holin_SPP1 PF04688.13 EFW99379.1 - 0.28 11.4 1.3 2.3 8.5 0.8 2.2 2 0 0 2 2 2 0 SPP1 phage holin zf-C2H2 PF00096.26 EFW99380.1 - 1.4e-11 44.2 12.3 1.2e-05 25.5 0.6 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFW99380.1 - 6.6e-09 35.9 8.4 0.00094 19.8 0.5 3.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFW99380.1 - 5e-07 29.8 11.9 5.3e-06 26.6 1.3 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EFW99380.1 - 4e-06 26.7 5.8 0.018 15.1 0.2 4.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EFW99380.1 - 0.019 14.7 8.9 0.51 10.2 0.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 EFW99380.1 - 0.054 14.0 7.4 3.4 8.2 1.5 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 EFW99380.1 - 0.089 13.1 0.1 0.089 13.1 0.1 3.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Aldedh PF00171.22 EFW99381.1 - 1e-117 393.5 0.3 1.3e-117 393.1 0.3 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ceramidase_alk PF04734.13 EFW99382.1 - 2.2e-221 735.9 0.0 2.5e-221 735.7 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EFW99382.1 - 6.5e-55 185.6 0.0 9.8e-55 185.0 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal tRNA-synt_1b PF00579.25 EFW99383.1 - 2.5e-58 197.7 0.0 3.3e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) ECR1_N PF14382.6 EFW99384.1 - 1.1e-14 53.9 0.5 1.1e-14 53.9 0.5 2.0 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region DUF4536 PF15055.6 EFW99384.1 - 1.3e-07 31.8 0.3 1.3e-07 31.8 0.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) KH_6 PF15985.5 EFW99384.1 - 4e-05 23.9 0.1 9e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 KH domain ECH_1 PF00378.20 EFW99385.1 - 1.1e-41 142.8 0.0 2.5e-41 141.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFW99385.1 - 3.6e-31 108.9 0.3 1.9e-27 96.6 0.0 2.3 2 1 1 3 3 3 2 Enoyl-CoA hydratase/isomerase CAP160 PF07918.11 EFW99386.1 - 0.25 11.1 0.7 0.25 11.1 0.7 1.9 2 0 0 2 2 2 0 CAP160 repeat Whi5 PF08528.11 EFW99387.1 - 1.7e-09 37.1 0.0 3e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Whi5 like PPR_2 PF13041.6 EFW99388.1 - 6.8e-40 135.0 8.3 1.7e-07 31.3 0.0 13.0 10 4 4 14 14 14 6 PPR repeat family PPR_3 PF13812.6 EFW99388.1 - 1.1e-29 102.3 0.0 5.5e-05 23.2 0.0 10.4 7 2 3 11 11 11 7 Pentatricopeptide repeat domain PPR PF01535.20 EFW99388.1 - 1.8e-22 78.0 21.5 0.0011 19.1 0.0 13.0 14 0 0 14 14 14 5 PPR repeat PPR_1 PF12854.7 EFW99388.1 - 4.9e-20 70.9 0.0 1.9e-06 27.4 0.0 9.2 9 0 0 9 9 9 4 PPR repeat PPR_long PF17177.4 EFW99388.1 - 6.4e-17 61.6 13.6 2.3e-06 27.1 0.3 6.6 3 2 2 6 6 6 3 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 EFW99388.1 - 0.0038 17.6 0.0 0.049 14.0 0.0 2.9 3 0 0 3 3 3 1 Mitochondrial ribonuclease P subunit (RPM2) ATP13 PF12921.7 EFW99388.1 - 0.039 13.8 0.8 1.8 8.4 0.1 3.6 3 1 1 4 4 4 0 Mitochondrial ATPase expression SelB-wing_2 PF09106.11 EFW99388.1 - 0.13 12.5 0.0 1.7 8.9 0.0 3.1 2 0 0 2 2 2 0 Elongation factor SelB, winged helix MR_MLE_C PF13378.6 EFW99389.1 - 3e-56 190.4 0.7 3.7e-56 190.1 0.7 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFW99389.1 - 4.9e-16 59.0 0.0 9.8e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DUF1989 PF09347.10 EFW99390.1 - 1.2e-49 168.2 0.1 5.4e-49 166.0 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1989) Polysacc_deac_1 PF01522.21 EFW99390.1 - 2e-16 60.0 0.0 3.6e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EFW99390.1 - 2e-07 30.9 0.0 3.4e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) La_HTH_kDCL PF18177.1 EFW99390.1 - 0.013 15.8 0.6 0.084 13.2 0.1 2.2 2 0 0 2 2 2 0 La HTH in kinetoplastid DICER domain HNH_2 PF13391.6 EFW99391.1 - 4.2e-13 49.2 0.0 7.9e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Ribosomal_S19 PF00203.21 EFW99392.1 - 3.4e-33 113.4 0.4 4.5e-33 113.0 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ofd1_CTDD PF10637.9 EFW99393.1 - 6e-90 301.0 0.6 4.3e-83 278.6 0.6 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EFW99393.1 - 5.5e-25 87.9 0.0 2e-24 86.0 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EFW99393.1 - 1.5e-12 48.2 0.0 5.3e-12 46.5 0.0 2.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1963 PF09234.10 EFW99393.1 - 0.0088 16.5 0.6 0.019 15.4 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1963) AP3D1 PF06375.11 EFW99393.1 - 1.1 9.4 29.8 0.24 11.6 9.6 3.4 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 DPPIV_N PF00930.21 EFW99394.1 - 1.4e-97 326.7 0.0 1.9e-97 326.2 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EFW99394.1 - 1.2e-52 178.5 1.0 2.1e-52 177.7 1.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFW99394.1 - 1.1e-05 25.1 1.8 0.0015 18.2 0.9 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 EFW99394.1 - 0.00057 19.6 0.3 0.0032 17.1 0.1 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold PD40 PF07676.12 EFW99394.1 - 0.043 13.8 2.2 0.079 12.9 0.0 2.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PAF-AH_p_II PF03403.13 EFW99394.1 - 0.072 11.6 0.0 0.25 9.8 0.0 1.8 2 1 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF1640 PF07798.11 EFW99395.1 - 4.9e-55 186.3 7.6 6e-55 186.0 7.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HU-CCDC81_bac_2 PF18175.1 EFW99395.1 - 0.058 13.3 1.5 0.64 9.9 0.7 2.4 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Diphthami_syn_2 PF01902.17 EFW99395.1 - 0.097 12.2 0.3 0.17 11.4 0.1 1.4 2 0 0 2 2 2 0 Diphthamide synthase cwf21 PF08312.12 EFW99395.1 - 1.7 8.9 5.4 1.5 9.0 3.2 2.1 2 1 0 2 2 2 0 cwf21 domain ATP-synt_ab PF00006.25 EFW99396.1 - 1.9e-66 223.8 0.0 2.8e-66 223.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFW99396.1 - 2.9e-13 50.1 0.6 5.8e-13 49.2 0.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF5535 PF17687.1 EFW99396.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5535) Peptidase_S8 PF00082.22 EFW99397.1 - 1.7e-36 126.0 0.9 1.7e-36 126.0 0.9 1.8 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 EFW99397.1 - 7.7e-26 89.9 1.1 1.8e-25 88.8 1.1 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EFW99397.1 - 0.00085 20.0 0.7 0.0023 18.7 0.7 1.8 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.5 EFW99397.1 - 0.04 14.4 0.1 0.22 12.0 0.0 2.2 2 0 0 2 2 2 0 N-terminal of Subtilase family zf-CCHC PF00098.23 EFW99399.1 - 6.3e-20 70.3 25.4 6.2e-09 35.5 1.7 4.6 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_6 PF15288.6 EFW99399.1 - 4.8e-05 23.1 6.2 0.57 10.1 0.1 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 EFW99399.1 - 0.0009 18.9 12.9 0.082 12.7 0.5 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 EFW99399.1 - 0.0022 17.8 1.1 0.0022 17.8 1.1 3.6 3 0 0 3 3 3 1 Zinc knuckle FdhE PF04216.12 EFW99399.1 - 0.32 10.8 5.4 0.51 10.2 4.7 1.7 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation zf-C2H2_10 PF16588.5 EFW99399.1 - 1.3 8.8 16.1 1.1 9.0 0.4 3.7 4 0 0 4 4 4 0 C2H2 zinc-finger Sacchrp_dh_NADP PF03435.18 EFW99401.1 - 5.1e-16 59.1 0.0 1e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EFW99401.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Semialdhyde_dh PF01118.24 EFW99401.1 - 0.1 13.1 0.0 0.33 11.4 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Ribosomal_L37ae PF01780.19 EFW99402.1 - 1e-37 128.1 10.2 1.1e-37 127.9 10.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EFW99402.1 - 0.034 14.1 5.8 0.058 13.4 5.8 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Piwi PF02171.17 EFW99403.1 - 1.6e-69 234.5 0.0 2.3e-69 234.0 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EFW99403.1 - 4.5e-15 56.5 0.3 7.8e-15 55.7 0.3 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EFW99403.1 - 7.5e-14 51.1 0.2 1.9e-13 49.9 0.2 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EFW99403.1 - 2.7e-09 37.2 0.0 8.9e-09 35.6 0.0 2.0 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EFW99403.1 - 4.2e-08 33.1 0.0 2.1e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 PAZ domain SIS PF01380.22 EFW99404.1 - 4.1e-61 204.6 0.2 5.7e-32 110.3 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EFW99404.1 - 8.3e-19 68.1 0.0 1.7e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EFW99404.1 - 4e-11 42.9 0.0 1e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EFW99404.1 - 0.001 18.0 0.0 0.0017 17.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PTSIIB_sorb PF03830.15 EFW99404.1 - 0.03 14.5 0.2 0.18 12.0 0.1 2.2 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component zf_CCCH_4 PF18345.1 EFW99405.1 - 0.037 14.1 6.8 0.06 13.4 6.8 1.4 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 EFW99405.1 - 0.2 11.6 5.9 0.37 10.8 5.9 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PIEZO PF15917.5 EFW99405.1 - 0.63 9.5 3.5 1.3 8.4 3.5 1.4 1 0 0 1 1 1 0 Piezo PhoD PF09423.10 EFW99406.1 - 0.00033 19.8 0.0 0.0018 17.3 0.0 2.0 1 1 0 1 1 1 1 PhoD-like phosphatase Pkinase PF00069.25 EFW99407.1 - 5.4e-64 216.1 0.0 1.7e-63 214.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99407.1 - 1.2e-29 103.4 0.0 2.4e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFW99407.1 - 0.0078 15.0 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFW99407.1 - 0.0099 15.2 0.0 0.024 14.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFW99407.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFW99407.1 - 0.023 14.6 0.1 0.53 10.2 0.1 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFW99407.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Yop-YscD_cpl PF16697.5 EFW99407.1 - 0.16 12.3 0.0 0.41 11.0 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Pox_ser-thr_kin PF05445.11 EFW99407.1 - 0.23 10.4 0.0 0.37 9.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase AAA_22 PF13401.6 EFW99408.1 - 9.5e-05 22.7 0.3 0.0024 18.1 0.1 2.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFW99408.1 - 0.0009 18.4 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EFW99408.1 - 0.0037 17.0 0.1 0.0037 17.0 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFW99408.1 - 0.044 14.1 0.8 0.54 10.6 0.1 2.3 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 EFW99408.1 - 0.047 13.3 0.3 0.1 12.2 0.1 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Mur_ligase_M PF08245.12 EFW99408.1 - 0.052 13.5 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 Mur ligase middle domain ABC_tran PF00005.27 EFW99408.1 - 0.057 13.9 0.0 0.057 13.9 0.0 2.6 2 1 0 2 2 2 0 ABC transporter PhoH PF02562.16 EFW99408.1 - 0.069 12.6 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_23 PF13476.6 EFW99408.1 - 0.1 13.1 0.0 0.1 13.1 0.0 3.5 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 EFW99408.1 - 0.26 11.3 1.8 9.5 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AhpC-TSA PF00578.21 EFW99409.1 - 2.4e-15 56.6 0.0 1.5e-11 44.3 0.0 2.2 1 1 1 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 EFW99409.1 - 1.8e-07 31.0 0.0 6e-06 26.0 0.0 2.2 1 1 1 2 2 2 2 Redoxin AhpC-TSA_2 PF13911.6 EFW99409.1 - 0.016 15.3 0.0 0.09 12.9 0.0 2.0 1 1 1 2 2 2 0 AhpC/TSA antioxidant enzyme Velvet PF11754.8 EFW99410.1 - 1.3e-52 179.3 0.3 2.4e-36 125.9 0.0 3.1 2 2 1 3 3 3 2 Velvet factor Glyco_transf_28 PF03033.20 EFW99411.1 - 1.2e-16 61.0 0.1 7.5e-16 58.4 0.1 2.2 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EFW99411.1 - 2.1e-05 23.5 0.0 3.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFW99411.1 - 0.0021 18.1 0.0 0.0051 16.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Dabb PF07876.12 EFW99412.1 - 1e-20 74.1 0.3 7.2e-20 71.4 0.3 1.8 1 1 0 1 1 1 1 Stress responsive A/B Barrel Domain RNase_T PF00929.24 EFW99413.1 - 3.7e-05 24.3 0.0 0.00012 22.7 0.0 1.8 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EFW99413.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 3'-5' exonuclease Noc2 PF03715.13 EFW99414.1 - 2e-119 398.3 0.0 3.4e-119 397.5 0.0 1.4 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 EFW99414.1 - 0.019 13.3 0.0 0.019 13.3 0.0 3.4 3 1 0 3 3 3 0 Nop14-like family Cwf_Cwc_15 PF04889.12 EFW99414.1 - 1.5 8.5 58.4 0.35 10.6 21.0 2.9 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein KR PF08659.10 EFW99415.1 - 2.2e-60 203.6 0.2 6.6e-60 202.1 0.2 1.9 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 EFW99415.1 - 1.5e-59 201.6 0.0 4.2e-59 200.2 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EFW99415.1 - 2e-47 161.9 0.9 4.9e-47 160.6 0.9 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFW99415.1 - 2.4e-46 158.7 0.3 5.8e-46 157.4 0.0 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFW99415.1 - 2.7e-33 114.5 0.0 7.1e-33 113.1 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 EFW99415.1 - 2.1e-19 70.9 1.0 2.1e-18 67.6 0.0 3.2 4 0 0 4 4 3 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EFW99415.1 - 1.5e-14 54.4 0.0 5.4e-14 52.6 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFW99415.1 - 1.4e-13 50.8 0.0 4.5e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase ADH_zinc_N PF00107.26 EFW99415.1 - 3.1e-12 46.6 0.0 1.2e-11 44.7 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFW99415.1 - 7e-08 32.3 0.7 1.8e-06 27.7 0.0 2.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EFW99415.1 - 3.9e-07 30.3 0.1 1.3e-06 28.7 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 EFW99415.1 - 2.3e-06 28.3 0.0 7.8e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain CoA_trans PF01144.23 EFW99415.1 - 0.0052 16.2 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 Coenzyme A transferase Thiolase_N PF00108.23 EFW99415.1 - 0.01 15.2 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain Methyltransf_25 PF13649.6 EFW99415.1 - 0.013 16.2 0.2 0.11 13.2 0.0 2.7 2 0 0 2 2 2 0 Methyltransferase domain NAD_binding_10 PF13460.6 EFW99415.1 - 0.016 15.1 0.0 0.065 13.1 0.0 2.1 1 0 0 1 1 1 0 NAD(P)H-binding ADH_N PF08240.12 EFW99415.1 - 0.031 14.2 0.0 0.08 12.8 0.0 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain 3Beta_HSD PF01073.19 EFW99415.1 - 0.033 13.2 0.0 0.052 12.6 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EFW99415.1 - 0.06 12.9 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.21 EFW99415.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family WD40_3 PF15911.5 EFW99415.1 - 0.094 12.7 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 WD domain, G-beta repeat DUF3712 PF12505.8 EFW99416.1 - 4.1e-26 91.7 3.7 4.1e-26 91.7 3.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) DUF3602 PF12223.8 EFW99417.1 - 3.2e-23 82.1 12.7 5.5e-23 81.4 4.2 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) Egh16-like PF11327.8 EFW99418.1 - 2.1e-46 158.7 10.1 2.5e-46 158.4 10.1 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor CAP59_mtransfer PF11735.8 EFW99419.1 - 3.1e-81 272.6 0.0 4.1e-81 272.2 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 RskA PF10099.9 EFW99419.1 - 0.27 11.5 3.1 7 6.9 0.3 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA tRNA-synt_His PF13393.6 EFW99420.1 - 4.7e-30 104.9 0.6 3.7e-29 102.0 0.6 2.2 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2 PF00152.20 EFW99420.1 - 0.00041 19.5 0.0 0.02 14.0 0.0 2.3 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) HGTP_anticodon PF03129.20 EFW99420.1 - 0.00046 20.3 0.1 0.0011 19.0 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFW99420.1 - 0.014 15.4 0.0 0.037 14.0 0.0 1.8 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) RasGAP_C PF03836.15 EFW99422.1 - 0.0056 16.8 1.4 0.0082 16.3 1.4 1.3 1 0 0 1 1 1 1 RasGAP C-terminus Spc7 PF08317.11 EFW99422.1 - 0.13 11.1 8.6 0.2 10.5 8.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein NBP1 PF08537.10 EFW99422.1 - 0.5 9.7 5.3 0.69 9.3 5.3 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 HIP1_clath_bdg PF16515.5 EFW99422.1 - 0.72 10.5 8.9 8.2 7.1 8.4 2.4 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 EFW99422.1 - 0.75 10.5 8.0 0.83 10.3 6.4 1.9 1 1 1 2 2 2 0 Initiation control protein YabA FlaC_arch PF05377.11 EFW99422.1 - 1.4 9.4 6.7 5.2 7.5 0.1 3.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3847 PF12958.7 EFW99422.1 - 5.5 7.2 10.0 5.7 7.1 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) H_lectin PF09458.10 EFW99423.1 - 3.9e-08 33.4 0.2 9.7e-07 28.9 0.0 2.4 1 1 1 2 2 2 1 H-type lectin domain Fib_alpha PF08702.10 EFW99423.1 - 0.0088 16.2 0.1 0.012 15.8 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family SlyX PF04102.12 EFW99423.1 - 0.061 13.9 0.3 0.1 13.2 0.3 1.3 1 0 0 1 1 1 0 SlyX FAM76 PF16046.5 EFW99423.1 - 0.065 12.6 0.0 0.083 12.2 0.0 1.1 1 0 0 1 1 1 0 FAM76 protein TMF_DNA_bd PF12329.8 EFW99423.1 - 0.067 13.2 0.7 0.093 12.7 0.7 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding SET PF00856.28 EFW99424.1 - 1.5e-12 48.2 0.0 2.3e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 SET domain Cullin PF00888.22 EFW99426.1 - 1.6e-161 539.0 0.0 2.3e-161 538.5 0.0 1.2 1 0 0 1 1 1 1 Cullin family PI3_PI4_kinase PF00454.27 EFW99426.1 - 3e-47 161.5 0.0 5.8e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EFW99426.1 - 6.1e-39 133.6 0.4 2.5e-38 131.6 0.4 2.2 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair Cullin_Nedd8 PF10557.9 EFW99426.1 - 2e-23 82.2 0.0 5.4e-23 80.8 0.0 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain FATC PF02260.20 EFW99426.1 - 6.9e-07 29.0 0.4 3.3e-06 26.8 0.2 2.3 2 0 0 2 2 2 1 FATC domain Sugar_tr PF00083.24 EFW99427.1 - 6.8e-51 173.5 31.5 6.5e-49 167.0 31.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFW99427.1 - 3.4e-16 59.1 38.3 5.6e-09 35.4 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFW99427.1 - 0.015 13.9 26.9 0.071 11.7 0.9 3.2 2 1 1 3 3 3 0 MFS/sugar transport protein DUF5134 PF17197.4 EFW99427.1 - 0.055 13.4 0.8 0.13 12.2 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) ABC_tran PF00005.27 EFW99428.1 - 8.8e-32 110.5 0.0 2e-31 109.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EFW99428.1 - 1.9e-21 77.0 10.9 2.7e-21 76.4 10.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EFW99428.1 - 1.7e-06 27.7 0.0 1.7e-05 24.4 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFW99428.1 - 0.00028 20.8 0.0 0.0014 18.6 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 EFW99428.1 - 0.0006 19.6 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EFW99428.1 - 0.012 14.9 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 EFW99428.1 - 0.023 14.5 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EFW99428.1 - 0.052 13.8 0.1 0.35 11.1 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFW99428.1 - 0.15 11.8 1.3 0.24 11.2 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFW99428.1 - 0.17 12.4 0.2 0.17 12.4 0.2 1.8 2 0 0 2 2 2 0 AAA domain MTABC_N PF16185.5 EFW99428.1 - 0.2 11.1 3.6 2.4 7.6 0.1 2.9 2 1 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region Peptidase_M28 PF04389.17 EFW99429.1 - 7.4e-36 123.7 0.0 9.6e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 DUF3224 PF11528.8 EFW99430.1 - 0.028 14.2 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3224) G-patch PF01585.23 EFW99431.1 - 0.09 12.7 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 G-patch domain Amino_oxidase PF01593.24 EFW99432.1 - 8e-66 223.2 0.0 1e-65 222.8 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFW99432.1 - 1.2e-08 35.1 0.0 3.3e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFW99432.1 - 8.3e-06 25.6 0.0 0.00036 20.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFW99432.1 - 0.0082 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFW99432.1 - 0.036 13.3 0.1 0.096 11.9 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFW99432.1 - 0.11 11.7 0.5 0.21 10.8 0.5 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EFW99432.1 - 0.14 10.8 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Fungal_trans_2 PF11951.8 EFW99433.1 - 0.082 11.7 2.5 0.12 11.2 0.2 2.3 2 1 0 2 2 2 0 Fungal specific transcription factor domain ANAPC_CDC26 PF10471.9 EFW99434.1 - 2.4e-08 34.7 3.3 2.4e-08 34.7 3.3 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex APC subunit CDC26 DNA_pol_B PF00136.21 EFW99435.1 - 1.2e-146 489.0 3.0 1.8e-146 488.5 3.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFW99435.1 - 3.9e-78 262.9 0.1 9.7e-78 261.6 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EFW99435.1 - 2e-15 57.0 4.3 5.1e-15 55.7 4.3 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.9 EFW99435.1 - 0.033 13.9 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DUF2614 PF11023.8 EFW99435.1 - 0.052 13.6 0.1 0.099 12.7 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain C1_1 PF00130.22 EFW99435.1 - 8 6.4 8.4 7.1 6.6 0.4 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Metallophos PF00149.28 EFW99436.1 - 8.5e-11 42.7 0.4 1.5e-10 41.9 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Collagen PF01391.18 EFW99436.1 - 0.29 10.9 9.7 0.045 13.5 4.9 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) VCX_VCY PF15231.6 EFW99436.1 - 1.5 9.5 6.1 4.1 8.1 6.1 1.7 1 0 0 1 1 1 0 Variable charge X/Y family Git3 PF11710.8 EFW99437.1 - 1.4e-16 60.9 11.2 6.8e-16 58.6 11.2 2.0 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EFW99437.1 - 1.8e-12 47.2 6.9 2.3e-12 46.8 6.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_2 PF00002.24 EFW99437.1 - 9.9e-08 31.6 9.8 9.9e-08 31.6 9.8 1.9 2 1 0 2 2 2 1 7 transmembrane receptor (Secretin family) GPR_Gpa2_C PF11970.8 EFW99437.1 - 1.2e-05 25.3 0.1 4.6e-05 23.4 0.1 2.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF4834 PF16118.5 EFW99437.1 - 0.61 11.1 0.0 0.61 11.1 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) TPR_8 PF13181.6 EFW99438.1 - 2.3e-09 36.7 10.7 3.6e-05 23.6 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFW99438.1 - 2.4e-07 30.3 4.3 0.042 13.7 0.6 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFW99438.1 - 8.2e-06 25.8 0.4 9.8 6.8 0.1 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFW99438.1 - 6.3e-05 23.1 3.5 0.99 9.6 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFW99438.1 - 0.00045 20.7 8.4 1.2 9.7 0.0 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFW99438.1 - 0.00047 20.0 1.7 0.081 13.0 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFW99438.1 - 0.0013 19.3 14.2 0.3 11.8 0.4 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 EFW99438.1 - 0.0041 17.2 0.5 0.015 15.4 0.2 1.9 2 0 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_14 PF13428.6 EFW99438.1 - 0.0051 17.5 14.5 11 7.2 0.0 5.9 4 3 3 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFW99438.1 - 0.071 13.3 19.3 0.2 11.9 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 EFW99438.1 - 0.13 12.3 1.9 5.4 7.2 0.0 3.4 4 0 0 4 4 4 0 Exonuclease VII small subunit ANAPC3 PF12895.7 EFW99438.1 - 0.14 12.4 5.7 6.1 7.1 0.1 3.2 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFW99438.1 - 0.21 12.3 0.4 0.21 12.3 0.4 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFW99438.1 - 0.32 10.9 5.3 0.36 10.8 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Questin_oxidase PF14027.6 EFW99439.1 - 2.1e-89 300.4 0.9 3.8e-89 299.6 0.9 1.3 1 0 0 1 1 1 1 Questin oxidase-like DUF676 PF05057.14 EFW99439.1 - 0.00014 21.4 0.0 0.00023 20.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EFW99439.1 - 0.0004 21.1 0.3 0.0004 21.1 0.3 3.5 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EFW99439.1 - 0.012 15.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase PGAP1 PF07819.13 EFW99439.1 - 0.036 13.8 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Mito_carr PF00153.27 EFW99440.1 - 1.7e-47 159.3 5.1 2.5e-18 65.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.25 EFW99441.1 - 1.8e-17 63.6 0.0 3.9e-17 62.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99441.1 - 4.1e-06 26.3 0.0 4.3e-05 22.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase zf-HC5HC2H_2 PF13832.6 EFW99442.1 - 9.5e-21 74.0 12.8 5.3e-19 68.4 0.5 3.8 3 0 0 3 3 3 1 PHD-zinc-finger like domain BAH PF01426.18 EFW99442.1 - 1.9e-15 56.8 0.0 3.6e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H PF13771.6 EFW99442.1 - 3.4e-15 56.1 0.7 3.4e-15 56.1 0.7 4.4 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD PF00628.29 EFW99442.1 - 3.1e-12 46.2 52.8 1.2e-06 28.3 7.5 6.1 6 0 0 6 6 6 3 PHD-finger PHD_2 PF13831.6 EFW99442.1 - 1.3e-08 34.3 3.5 1.3e-08 34.3 3.5 4.9 5 0 0 5 5 5 1 PHD-finger FYVE_2 PF02318.16 EFW99442.1 - 0.00086 19.5 3.9 0.00086 19.5 3.9 4.1 5 0 0 5 5 5 1 FYVE-type zinc finger Prok-RING_1 PF14446.6 EFW99442.1 - 0.0062 16.4 2.6 0.0062 16.4 2.6 4.5 5 0 0 5 5 4 1 Prokaryotic RING finger family 1 C1_1 PF00130.22 EFW99442.1 - 0.007 16.2 1.2 0.007 16.2 1.2 5.2 5 1 1 6 6 6 3 Phorbol esters/diacylglycerol binding domain (C1 domain) ELM2 PF01448.24 EFW99442.1 - 0.0074 17.0 4.7 0.022 15.5 0.4 3.4 2 0 0 2 2 2 1 ELM2 domain DUF4606 PF15379.6 EFW99442.1 - 0.19 12.0 1.1 0.79 10.0 1.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) DUF3915 PF13054.6 EFW99442.1 - 0.23 11.4 17.0 0.034 14.1 4.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) GATA PF00320.27 EFW99442.1 - 2 8.1 7.9 1.5 8.5 1.6 3.5 3 0 0 3 3 3 0 GATA zinc finger Zf_RING PF16744.5 EFW99442.1 - 4.4 7.5 36.5 2 8.6 3.6 4.6 3 2 0 3 3 3 0 KIAA1045 RING finger SAS4 PF15460.6 EFW99443.1 - 3.3e-31 107.3 0.2 3.3e-31 107.3 0.2 1.8 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 Adaptin_binding PF10199.9 EFW99443.1 - 1.2 9.8 10.2 0.062 13.9 3.8 2.2 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 FYDLN_acid PF09538.10 EFW99443.1 - 3.6 8.3 11.2 18 6.1 11.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) WD40 PF00400.32 EFW99446.1 - 1.9e-14 53.8 9.7 0.014 16.3 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 EFW99446.1 - 4.5e-05 22.3 4.6 0.00017 20.4 0.6 3.2 3 2 1 4 4 4 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFW99446.1 - 0.00016 21.9 0.2 0.055 13.8 0.2 3.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SRP72 PF08492.12 EFW99446.1 - 6.1 7.3 9.2 16 6.1 1.6 3.0 3 0 0 3 3 3 0 SRP72 RNA-binding domain DUF726 PF05277.12 EFW99447.1 - 3.8e-126 420.7 1.9 6e-126 420.0 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) HEPN_MAE_28990 PF18737.1 EFW99447.1 - 0.095 12.6 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 MAE_28990/MAE_18760-like HEPN Lipase_GDSL_2 PF13472.6 EFW99448.1 - 9.4e-23 81.5 0.0 1.3e-22 81.1 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFW99448.1 - 2.1e-07 31.2 0.0 4.8e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CUE PF02845.16 EFW99448.1 - 0.034 13.9 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 CUE domain Syntaxin-6_N PF09177.11 EFW99449.1 - 9.1e-24 83.9 0.1 7.9e-23 80.9 0.0 2.1 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EFW99449.1 - 0.0025 17.8 2.2 0.0036 17.3 0.5 2.0 2 0 0 2 2 2 1 SNARE domain Prominin PF05478.11 EFW99449.1 - 0.03 12.3 0.0 0.039 11.9 0.0 1.2 1 0 0 1 1 1 0 Prominin Use1 PF09753.9 EFW99449.1 - 0.031 14.0 0.1 0.046 13.4 0.1 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 DegS PF05384.11 EFW99449.1 - 0.034 13.6 0.2 0.034 13.6 0.2 1.9 2 0 0 2 2 2 0 Sensor protein DegS DUF745 PF05335.13 EFW99449.1 - 0.037 13.7 2.4 0.1 12.3 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Herpes_US9 PF06072.11 EFW99449.1 - 0.065 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Arrestin_C PF02752.22 EFW99450.1 - 1.2e-10 41.9 0.2 8.7e-09 35.9 0.3 2.9 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain MFS_1 PF07690.16 EFW99451.1 - 6.5e-14 51.6 52.4 3.3e-12 46.0 15.3 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily Ribosomal_60s PF00428.19 EFW99452.1 - 9.7e-26 90.2 12.0 1.1e-25 90.0 12.0 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein UBA_6 PF18039.1 EFW99452.1 - 0.091 12.7 0.4 0.14 12.1 0.0 1.5 2 0 0 2 2 2 0 UBA-like domain Carb_kinase PF01256.17 EFW99453.1 - 3.6e-52 177.3 0.2 6.8e-52 176.4 0.2 1.5 1 1 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EFW99453.1 - 0.00058 19.3 0.0 0.00093 18.6 0.0 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 EFW99453.1 - 0.024 14.0 0.0 0.051 12.9 0.0 1.5 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase RNA_pol_Rpb1_1 PF04997.12 EFW99454.1 - 2.7e-105 352.1 0.1 4.4e-105 351.5 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EFW99454.1 - 4e-101 337.9 0.0 7.4e-101 337.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFW99454.1 - 7.4e-77 257.2 0.0 2.6e-76 255.5 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EFW99454.1 - 7.5e-60 202.0 3.4 1.4e-59 201.1 3.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EFW99454.1 - 3.8e-45 153.6 0.0 8.6e-45 152.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EFW99454.1 - 1.7e-43 147.9 4.3 1.2e-42 145.1 5.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EFW99454.1 - 4.4e-36 123.1 0.1 1e-35 121.9 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EFW99454.1 - 0.02 15.3 185.1 0.015 15.7 9.4 12.7 10 4 2 12 12 12 0 RNA polymerase Rpb1 C-terminal repeat AA_permease_2 PF13520.6 EFW99455.1 - 1.1e-38 133.2 55.5 1.5e-38 132.7 55.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFW99455.1 - 1.5e-15 56.8 44.4 2.1e-15 56.3 44.4 1.1 1 0 0 1 1 1 1 Amino acid permease CH PF00307.31 EFW99457.1 - 8.2e-13 48.5 0.0 1.4e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF3439 PF11921.8 EFW99457.1 - 0.014 15.4 3.7 0.037 14.0 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF155 PF02582.14 EFW99458.1 - 5.6e-50 169.9 0.3 8.7e-50 169.2 0.3 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 ABC_membrane_2 PF06472.15 EFW99459.1 - 1.8e-97 326.0 0.3 2.7e-97 325.4 0.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFW99459.1 - 1.8e-17 64.1 0.0 5.5e-17 62.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EFW99459.1 - 0.0004 20.3 0.0 0.00097 19.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFW99459.1 - 0.08 13.4 0.0 0.19 12.2 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFW99459.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EFW99459.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFW99459.1 - 0.17 12.2 1.8 0.31 11.4 0.2 2.2 3 0 0 3 3 3 0 AAA ATPase domain Thg1 PF04446.12 EFW99460.1 - 4.6e-53 178.5 0.0 6.9e-53 178.0 0.0 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EFW99460.1 - 2.8e-37 127.6 0.0 4e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain Ribophorin_II PF05817.14 EFW99461.1 - 3.8e-30 105.0 0.0 7.1e-30 104.1 0.0 1.4 1 1 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Zn_clus PF00172.18 EFW99462.1 - 2.7e-08 33.8 12.0 5.3e-08 32.9 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFW99462.1 - 0.00087 18.2 1.7 0.0012 17.8 1.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain GlcNAc_2-epim PF07221.11 EFW99462.1 - 0.089 12.0 0.8 2.7 7.2 0.2 2.2 2 0 0 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) PH PF00169.29 EFW99464.1 - 7.1e-08 32.9 0.0 3.7e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EFW99464.1 - 0.02 15.2 0.0 0.057 13.8 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3328 PF11807.8 EFW99466.1 - 9.2e-18 64.8 4.3 9.2e-18 64.8 4.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) GCV_T PF01571.21 EFW99467.1 - 1.6e-79 266.9 0.0 2e-79 266.6 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EFW99467.1 - 1.5e-22 79.3 0.3 3e-22 78.3 0.3 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain DUF3659 PF12396.8 EFW99467.1 - 0.0039 17.1 0.1 0.016 15.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3659) RL10P_insert PF17777.1 EFW99468.1 - 3.5e-20 71.8 0.0 5.9e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EFW99468.1 - 7e-17 61.4 0.0 1.3e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Zn_clus PF00172.18 EFW99469.1 - 7.1e-06 26.0 13.9 7.1e-06 26.0 13.9 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFW99469.1 - 1.1e-05 24.6 0.0 1.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PhoU PF01895.19 EFW99469.1 - 0.062 13.8 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 PhoU domain AAA_16 PF13191.6 EFW99470.1 - 0.00094 19.6 0.0 0.0029 18.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFW99470.1 - 0.063 13.6 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFW99470.1 - 0.075 13.2 0.0 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 EFW99470.1 - 0.1 11.6 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_28 PF13521.6 EFW99470.1 - 0.14 12.4 0.1 0.38 11.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain FAM212 PF15342.6 EFW99470.1 - 0.19 11.5 0.5 6.7 6.6 0.0 2.6 2 0 0 2 2 2 0 FAM212 family Cerato-platanin PF07249.12 EFW99471.1 - 8.1e-61 203.4 6.0 9.2e-61 203.2 6.0 1.0 1 0 0 1 1 1 1 Cerato-platanin Arf PF00025.21 EFW99472.1 - 2.5e-15 56.4 0.0 9.3e-15 54.5 0.0 1.9 1 1 1 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EFW99472.1 - 2.5e-06 27.7 0.0 5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFW99472.1 - 0.00053 19.6 0.0 0.00095 18.8 0.0 1.4 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFW99472.1 - 0.0056 16.1 0.0 0.0098 15.3 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EFW99472.1 - 0.024 15.1 0.0 0.061 13.8 0.0 1.7 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 EFW99472.1 - 0.036 14.1 0.0 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF5535 PF17687.1 EFW99472.1 - 0.072 13.3 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5535) RsgA_GTPase PF03193.16 EFW99472.1 - 0.087 12.7 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF410 PF04190.13 EFW99472.1 - 0.18 11.6 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF410) IF-2B PF01008.17 EFW99473.1 - 2e-35 122.4 0.0 3.4e-35 121.6 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family Melibiase_2_C PF17450.2 EFW99473.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain FA_desaturase PF00487.24 EFW99474.1 - 9.2e-21 74.8 10.5 1.1e-20 74.5 10.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase MPP6 PF10175.9 EFW99475.1 - 0.92 10.0 5.9 0.15 12.5 1.1 2.1 2 0 0 2 2 2 0 M-phase phosphoprotein 6 CENP-B_dimeris PF09026.10 EFW99475.1 - 9.2 6.7 19.9 0.5 10.8 9.4 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain p450 PF00067.22 EFW99477.1 - 8.3e-48 163.3 0.0 9.5e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Yos1 PF08571.10 EFW99479.1 - 6.9e-37 125.6 0.8 7.6e-37 125.4 0.8 1.0 1 0 0 1 1 1 1 Yos1-like Tim44 PF04280.15 EFW99480.1 - 2.3e-37 128.3 0.0 6.2e-37 127.0 0.0 1.8 1 0 0 1 1 1 1 Tim44-like domain CDC45 PF02724.14 EFW99480.1 - 0.35 9.1 16.6 0.6 8.3 16.6 1.3 1 0 0 1 1 1 0 CDC45-like protein PaREP1 PF05942.11 EFW99480.1 - 2.8 7.9 6.7 0.15 12.0 0.4 2.1 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family NPR3 PF03666.13 EFW99480.1 - 7.5 5.2 16.4 13 4.5 16.4 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Med14 PF08638.11 EFW99481.1 - 1.6e-61 207.1 0.0 1.6e-61 207.1 0.0 1.7 2 0 0 2 2 2 1 Mediator complex subunit MED14 SUIM_assoc PF16619.5 EFW99481.1 - 5.2 7.2 13.0 0.088 12.9 4.3 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA PF00004.29 EFW99482.1 - 1.6e-42 145.0 0.0 3e-42 144.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFW99482.1 - 1.4e-12 47.3 0.1 3.2e-11 43.0 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFW99482.1 - 3.8e-10 39.4 0.1 9.1e-10 38.2 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFW99482.1 - 6.4e-08 33.2 0.0 6.1e-05 23.5 0.1 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFW99482.1 - 1.7e-06 28.1 0.1 3.8e-05 23.7 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFW99482.1 - 2.4e-06 27.8 0.0 9.2e-06 25.9 0.0 2.0 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFW99482.1 - 6.8e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFW99482.1 - 0.00013 22.5 0.0 0.0021 18.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFW99482.1 - 0.00023 21.5 0.1 0.006 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EFW99482.1 - 0.00032 20.0 0.0 0.00065 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFW99482.1 - 0.0012 18.4 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EFW99482.1 - 0.0022 17.2 0.0 0.0043 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Prot_ATP_OB_N PF17758.1 EFW99482.1 - 0.0035 16.9 0.0 0.01 15.5 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 EFW99482.1 - 0.004 17.3 0.0 0.009 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EFW99482.1 - 0.0042 16.5 0.0 0.0079 15.6 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EFW99482.1 - 0.0042 17.1 0.0 0.0089 16.0 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EFW99482.1 - 0.0054 16.5 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EFW99482.1 - 0.0059 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EFW99482.1 - 0.0075 16.3 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFW99482.1 - 0.0081 15.9 0.0 0.027 14.2 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_11 PF13086.6 EFW99482.1 - 0.0083 15.9 0.3 0.26 11.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EFW99482.1 - 0.012 15.5 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFW99482.1 - 0.019 14.7 0.1 0.057 13.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain ATPase PF06745.13 EFW99482.1 - 0.033 13.6 0.4 0.12 11.7 0.0 2.1 3 0 0 3 3 3 0 KaiC Thymidylate_kin PF02223.17 EFW99482.1 - 0.038 13.7 0.1 3.8 7.2 0.0 2.6 3 0 0 3 3 2 0 Thymidylate kinase AAA_30 PF13604.6 EFW99482.1 - 0.04 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFW99482.1 - 0.055 13.4 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 EFW99482.1 - 0.063 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EFW99482.1 - 0.088 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFW99482.1 - 0.096 12.0 0.2 0.26 10.5 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EFW99482.1 - 0.097 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EFW99482.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 OmpH PF03938.14 EFW99482.1 - 0.98 9.8 5.2 0.97 9.8 1.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HSP70 PF00012.20 EFW99483.1 - 3.5e-07 28.8 0.1 2e-05 23.0 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein HCNGP PF07818.13 EFW99484.1 - 2e-25 89.3 0.0 3.1e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 HCNGP-like protein Pkinase PF00069.25 EFW99485.1 - 5.5e-33 114.4 0.0 1.3e-18 67.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99485.1 - 2.5e-10 40.1 0.0 1.5e-05 24.4 0.0 3.3 2 2 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFW99485.1 - 1.1e-05 25.5 0.4 0.0032 17.4 0.0 2.8 2 1 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFW99485.1 - 0.0083 15.5 0.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Tim17 PF02466.19 EFW99486.1 - 1.7e-15 57.4 0.0 4.6e-15 55.9 0.0 1.6 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family FMN_dh PF01070.18 EFW99487.1 - 3.1e-100 335.6 0.2 3.6e-100 335.4 0.2 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EFW99487.1 - 9.3e-19 67.4 0.0 3e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 EFW99487.1 - 1.5e-05 24.2 0.0 0.00088 18.4 0.0 2.8 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EFW99487.1 - 2.6e-05 23.5 0.0 2.6e-05 23.5 0.0 1.5 2 0 0 2 2 2 1 Conserved region in glutamate synthase Ribosomal_S17_N PF16205.5 EFW99488.1 - 4e-33 113.6 0.2 6.3e-33 113.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EFW99488.1 - 1.9e-26 92.0 0.1 3.7e-26 91.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 G6PD_C PF02781.16 EFW99489.1 - 1.8e-113 378.5 0.0 2.7e-113 378.0 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EFW99489.1 - 2.4e-59 200.9 0.0 3.8e-59 200.3 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain ATP-synt_E PF05680.12 EFW99490.1 - 5.5e-25 87.5 0.1 6e-25 87.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain DUF349 PF03993.12 EFW99490.1 - 0.0038 17.5 0.1 0.0053 17.0 0.1 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF349) EFhand_Ca_insen PF08726.10 EFW99490.1 - 0.044 13.9 0.1 0.055 13.6 0.1 1.2 1 0 0 1 1 1 0 Ca2+ insensitive EF hand MMS19_N PF14500.6 EFW99491.1 - 2.5e-39 135.5 2.3 3.7e-38 131.6 0.9 2.9 2 1 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 EFW99491.1 - 3e-18 66.2 0.9 8e-18 64.8 0.9 1.7 1 0 0 1 1 1 1 RNAPII transcription regulator C-terminal Peptidase_A4 PF01828.17 EFW99492.1 - 8.2e-55 185.5 11.0 8.2e-55 185.5 11.0 1.4 2 0 0 2 2 2 1 Peptidase A4 family nos_propeller_2 PF18793.1 EFW99492.1 - 0.067 13.5 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Nitrous oxide reductase propeller repeat 2 TPR_1 PF00515.28 EFW99493.1 - 2.6e-23 80.8 4.1 6.2e-07 29.0 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFW99493.1 - 2.6e-22 77.1 10.0 4.6e-06 26.3 0.1 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFW99493.1 - 1.2e-16 60.0 10.6 2.5e-06 27.8 0.0 6.1 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFW99493.1 - 1.8e-15 57.3 11.5 2.2e-06 28.2 0.2 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFW99493.1 - 1.9e-14 53.9 8.2 1.1e-05 25.9 0.1 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFW99493.1 - 1.2e-13 50.0 4.1 0.039 14.0 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFW99493.1 - 4.1e-13 48.8 9.9 1.1e-06 28.2 0.0 5.4 4 2 2 6 6 6 2 TPR repeat TPR_17 PF13431.6 EFW99493.1 - 9.2e-13 47.6 2.7 0.0028 17.9 0.1 5.1 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFW99493.1 - 3.4e-12 45.5 10.8 0.00019 21.4 0.0 5.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFW99493.1 - 1.2e-10 41.5 10.4 4.5e-05 23.7 0.2 4.3 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_20 PF14561.6 EFW99493.1 - 2.3e-10 40.7 2.5 0.00024 21.4 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFW99493.1 - 3.4e-10 39.9 2.2 0.00011 22.3 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFW99493.1 - 2.3e-07 31.0 2.4 0.42 11.3 0.0 5.8 5 1 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFW99493.1 - 6.7e-07 29.4 5.9 0.0026 17.9 0.5 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EFW99493.1 - 2.6e-05 23.6 2.0 0.059 12.6 0.8 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFW99493.1 - 0.011 15.6 13.0 0.24 11.3 0.3 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat CRISPR_Cse2 PF09485.10 EFW99493.1 - 0.065 13.8 0.5 0.065 13.8 0.5 2.4 2 2 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DUF1641 PF07849.11 EFW99493.1 - 0.12 12.2 0.2 0.25 11.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_3 PF07720.12 EFW99493.1 - 0.19 11.8 1.2 40 4.3 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TFIIA PF03153.13 EFW99493.1 - 0.28 11.2 12.3 0.44 10.5 12.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribul_P_3_epim PF00834.19 EFW99494.1 - 3.7e-62 209.3 0.0 2.5e-61 206.5 0.0 1.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 EFW99494.1 - 0.0026 17.1 1.0 0.0035 16.7 1.0 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG DUF3418 PF11898.8 EFW99495.1 - 0.032 12.9 0.7 0.034 12.8 0.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) tRNA_int_end_N2 PF12928.7 EFW99496.1 - 6.3e-21 74.3 0.1 1.2e-20 73.5 0.1 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Yae1_N PF09811.9 EFW99497.1 - 2.7e-11 43.0 4.3 5.8e-11 41.9 4.3 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal CR6_interact PF10147.9 EFW99497.1 - 0.002 17.9 1.4 0.0032 17.2 1.4 1.3 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 RCR PF12273.8 EFW99497.1 - 0.057 14.1 2.4 4.8 7.8 1.9 3.4 3 1 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red PH PF00169.29 EFW99498.1 - 0.0026 18.2 0.0 0.0058 17.1 0.0 1.5 1 0 0 1 1 1 1 PH domain FAM193_C PF15914.5 EFW99498.1 - 0.13 12.0 0.4 0.36 10.6 0.1 1.8 2 0 0 2 2 2 0 FAM193 family C-terminal UQ_con PF00179.26 EFW99499.1 - 1.1e-35 122.4 0.0 1.6e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFW99499.1 - 0.018 15.3 0.1 0.04 14.2 0.1 1.6 1 1 0 1 1 1 0 RWD domain TMEM239 PF15841.5 EFW99502.1 - 0.29 11.0 7.2 12 5.8 0.1 3.2 3 0 0 3 3 3 0 Transmembrane protein 239 family CarbpepA_inh PF02977.15 EFW99502.1 - 1.5 8.7 14.4 0.7 9.7 0.5 3.4 3 0 0 3 3 3 0 Carboxypeptidase A inhibitor TIM PF00121.18 EFW99503.1 - 1.6e-86 289.6 0.1 1.8e-86 289.4 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase zf-ZPR1 PF03367.13 EFW99504.1 - 2.1e-111 369.0 0.0 4.5e-55 185.8 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zf-RRPl_C4 PF17026.5 EFW99504.1 - 0.058 13.5 0.5 15 5.8 0.0 2.2 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zinc-ribbons_6 PF07191.12 EFW99504.1 - 0.16 12.0 3.2 2 8.4 0.5 2.4 2 0 0 2 2 2 0 zinc-ribbons RNB PF00773.19 EFW99505.1 - 3.3e-79 266.6 0.0 3.3e-79 266.6 0.0 2.3 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 EFW99505.1 - 1.1e-25 89.5 0.0 2.8e-25 88.1 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EFW99505.1 - 5.5e-25 87.5 0.0 5.5e-25 87.5 0.0 3.4 2 1 0 2 2 2 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EFW99505.1 - 1.8e-05 24.8 0.0 0.025 14.7 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain GREB1 PF15782.5 EFW99505.1 - 0.077 10.1 17.6 0.12 9.5 17.6 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Otopetrin PF03189.13 EFW99505.1 - 0.93 8.2 7.7 1.6 7.4 7.7 1.3 1 0 0 1 1 1 0 Otopetrin DUF5308 PF17233.2 EFW99505.1 - 2.9 8.1 21.5 0.16 12.2 9.6 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5308) PA26 PF04636.13 EFW99505.1 - 5.8 5.7 14.1 15 4.4 14.1 1.6 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) NPR3 PF03666.13 EFW99505.1 - 5.8 5.6 38.3 0.49 9.1 1.0 2.9 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_L35Ae PF01247.18 EFW99506.1 - 1.9e-41 140.2 0.7 2.1e-41 140.0 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EFW99506.1 - 2.6e-06 27.6 0.1 0.02 15.1 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain WW PF00397.26 EFW99507.1 - 2.1e-10 40.5 0.1 4.1e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 WW domain FMO-like PF00743.19 EFW99508.1 - 9.3e-28 96.9 0.0 6.2e-14 51.3 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFW99508.1 - 4e-09 36.1 0.0 2.2e-08 33.7 0.0 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFW99508.1 - 8.7e-09 35.1 2.8 1.6e-07 30.9 0.2 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFW99508.1 - 4.9e-07 29.2 0.4 2.3e-05 23.7 0.0 2.7 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFW99508.1 - 0.0049 16.9 0.0 0.55 10.2 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFW99508.1 - 0.0088 16.3 0.0 0.027 14.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain RRM_1 PF00076.22 EFW99509.1 - 7.6e-13 48.1 0.0 1.1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFW99509.1 - 0.043 13.9 0.2 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 RNA binding motif HET PF06985.11 EFW99510.1 - 1.6e-11 44.8 4.1 1e-08 35.7 0.4 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Podoplanin PF05808.11 EFW99511.1 - 4.1e-06 27.0 0.9 4.1e-06 27.0 0.9 1.9 2 1 0 2 2 2 1 Podoplanin VSP PF03302.13 EFW99511.1 - 0.0014 17.5 0.2 0.0024 16.8 0.2 1.3 1 0 0 1 1 1 1 Giardia variant-specific surface protein Amnionless PF14828.6 EFW99511.1 - 0.0017 17.3 0.1 0.0031 16.4 0.1 1.3 1 0 0 1 1 1 1 Amnionless DUF4690 PF15756.5 EFW99511.1 - 0.0057 17.2 0.4 0.0057 17.2 0.4 2.8 3 0 0 3 3 3 1 Small Novel Rich in Cartilage Rax2 PF12768.7 EFW99511.1 - 0.009 15.5 0.1 0.015 14.8 0.1 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity SKG6 PF08693.10 EFW99511.1 - 0.0096 15.3 2.0 0.0096 15.3 2.0 3.0 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 EFW99511.1 - 0.01 15.6 0.6 0.026 14.3 0.6 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EssA PF10661.9 EFW99511.1 - 0.1 12.5 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA Methyltransf_25 PF13649.6 EFW99512.1 - 1.5e-07 32.0 0.0 2.6e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFW99512.1 - 2.7e-07 31.1 0.0 4.6e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99512.1 - 0.00027 20.8 0.0 0.00038 20.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99512.1 - 0.00082 20.1 0.0 0.0016 19.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW99512.1 - 0.12 12.2 0.0 0.73 9.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain SET PF00856.28 EFW99513.1 - 2.3e-12 47.6 0.0 1.3e-11 45.2 0.0 2.0 1 1 0 1 1 1 1 SET domain Epimerase PF01370.21 EFW99514.1 - 9.5e-18 64.5 0.0 1.3e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFW99514.1 - 4.6e-07 29.2 0.0 1.2e-06 27.9 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EFW99514.1 - 0.0001 21.4 0.0 0.00019 20.5 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFW99514.1 - 0.00013 21.5 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFW99514.1 - 0.09 13.0 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain IQ PF00612.27 EFW99515.1 - 5.6e-06 25.7 2.4 2e-05 24.0 2.4 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lyase_1 PF00206.20 EFW99516.1 - 4.2e-18 65.8 0.1 8.1e-18 64.9 0.1 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EFW99516.1 - 7.5e-13 48.8 0.0 2.3e-12 47.3 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus PIP5K PF01504.18 EFW99517.1 - 9.7e-32 110.3 11.3 1e-25 90.5 0.7 3.4 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EFW99517.1 - 4.2e-25 88.3 0.0 7.9e-25 87.4 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EFW99517.1 - 8.5e-13 48.2 7.1 1.9e-12 47.1 7.1 1.6 1 0 0 1 1 1 1 FYVE zinc finger MMM1 PF10296.9 EFW99517.1 - 0.0052 15.9 0.0 0.066 12.3 0.0 2.9 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 DUF2470 PF10615.9 EFW99518.1 - 2.8e-18 66.3 0.1 5e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) ADK PF00406.22 EFW99519.1 - 1e-34 119.8 0.0 4.1e-20 72.4 0.0 2.1 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EFW99519.1 - 1.2e-14 54.9 0.0 7.5e-10 39.4 0.0 2.3 1 1 0 2 2 2 2 AAA domain ADK_lid PF05191.14 EFW99519.1 - 1.3e-12 47.4 0.0 2.2e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EFW99519.1 - 5.2e-06 27.0 0.0 0.00021 21.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFW99519.1 - 0.00049 20.3 0.0 0.0023 18.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFW99519.1 - 0.068 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFW99519.1 - 0.18 12.1 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain CDP-OH_P_transf PF01066.21 EFW99521.1 - 5.2e-16 59.2 0.4 5.2e-16 59.2 0.4 3.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase p450 PF00067.22 EFW99522.1 - 1.8e-42 145.6 0.0 2.5e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HpcH_HpaI PF03328.14 EFW99524.1 - 5.6e-30 104.1 0.5 2.5e-29 102.0 0.0 2.2 2 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EFW99524.1 - 7.4e-10 38.5 0.0 0.00049 19.3 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold BolA PF01722.18 EFW99525.1 - 1.1e-27 96.1 0.2 1.5e-27 95.6 0.2 1.1 1 0 0 1 1 1 1 BolA-like protein DUF846 PF05832.12 EFW99526.1 - 5e-50 169.2 3.7 6e-50 168.9 3.7 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF5504 PF17608.2 EFW99526.1 - 0.0014 18.8 1.0 0.0014 18.8 1.0 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5504) VMA21 PF09446.10 EFW99527.1 - 1.3e-15 57.2 9.4 1.9e-15 56.7 9.4 1.3 1 0 0 1 1 1 1 VMA21-like domain DUF1772 PF08592.11 EFW99527.1 - 0.052 13.9 0.1 0.06 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Bacillus_HBL PF05791.11 EFW99528.1 - 2.7e-05 24.1 2.3 0.035 13.9 0.3 2.3 1 1 1 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) DUF16 PF01519.16 EFW99528.1 - 9.9e-05 22.8 5.9 0.35 11.4 0.7 3.7 1 1 1 2 2 2 2 Protein of unknown function DUF16 Yippee-Mis18 PF03226.14 EFW99528.1 - 0.00017 21.8 1.0 0.00041 20.5 1.0 1.6 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF1664 PF07889.12 EFW99528.1 - 0.00036 20.6 8.9 0.00065 19.7 1.7 2.7 2 1 1 3 3 2 1 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 EFW99528.1 - 0.00079 19.0 6.1 0.00079 19.0 6.1 2.0 2 0 0 2 2 2 1 Golgin subfamily A member 5 Baculo_PEP_C PF04513.12 EFW99528.1 - 0.0049 16.9 0.3 1.8 8.6 0.5 2.9 2 1 1 3 3 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_II PF06009.12 EFW99528.1 - 0.0054 16.7 1.2 0.022 14.8 0.6 1.9 1 1 0 1 1 1 1 Laminin Domain II DUF2046 PF09755.9 EFW99528.1 - 0.0054 16.0 3.2 0.0097 15.2 3.2 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) Fez1 PF06818.15 EFW99528.1 - 0.0057 17.1 4.5 0.0057 17.1 4.5 2.3 2 1 0 2 2 2 1 Fez1 Spectrin PF00435.21 EFW99528.1 - 0.0062 17.0 1.1 0.0062 17.0 1.1 3.2 2 1 0 3 3 3 1 Spectrin repeat Spc7 PF08317.11 EFW99528.1 - 0.0092 14.9 0.8 0.0092 14.9 0.8 2.4 1 1 1 3 3 3 1 Spc7 kinetochore protein APG17 PF04108.12 EFW99528.1 - 0.011 14.9 1.2 0.041 13.0 1.1 1.8 1 1 0 1 1 1 0 Autophagy protein Apg17 EzrA PF06160.12 EFW99528.1 - 0.018 13.3 0.2 0.027 12.7 0.2 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Csm1_N PF18504.1 EFW99528.1 - 0.027 14.8 12.0 0.44 10.9 1.0 4.8 4 1 1 5 5 5 0 Csm1 N-terminal domain Filament PF00038.21 EFW99528.1 - 0.043 13.4 15.6 0.024 14.2 5.0 2.7 2 1 1 3 3 2 0 Intermediate filament protein HAUS-augmin3 PF14932.6 EFW99528.1 - 0.055 13.0 2.4 0.063 12.8 0.8 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Med9 PF07544.13 EFW99528.1 - 0.056 13.5 1.7 0.11 12.6 0.5 2.1 2 0 0 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 GAS PF13851.6 EFW99528.1 - 0.069 12.5 6.0 0.041 13.2 0.8 2.5 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF5082 PF16888.5 EFW99528.1 - 0.091 13.0 6.6 9.8 6.5 0.6 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) AAA_13 PF13166.6 EFW99528.1 - 0.15 10.7 0.8 0.65 8.6 0.7 1.6 1 1 1 2 2 2 0 AAA domain Occludin_ELL PF07303.13 EFW99528.1 - 0.16 12.7 1.2 16 6.3 0.1 3.2 1 1 2 3 3 3 0 Occludin homology domain NPV_P10 PF05531.12 EFW99528.1 - 0.18 12.3 3.5 17 5.9 0.3 3.5 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein DUF641 PF04859.12 EFW99528.1 - 0.21 11.9 5.3 0.7 10.2 0.7 3.2 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EFW99528.1 - 0.23 12.1 15.1 9.9 6.9 0.4 5.0 2 1 3 5 5 5 0 SlyX TPR_MLP1_2 PF07926.12 EFW99528.1 - 0.29 11.2 8.2 0.068 13.2 1.5 3.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein YlqD PF11068.8 EFW99528.1 - 0.36 11.2 9.5 6.4 7.2 0.1 2.9 1 1 2 3 3 3 0 YlqD protein Fzo_mitofusin PF04799.13 EFW99528.1 - 0.37 10.3 5.0 14 5.2 0.1 3.1 1 1 2 3 3 3 0 fzo-like conserved region TMF_TATA_bd PF12325.8 EFW99528.1 - 0.66 10.2 15.1 6.8 6.9 0.0 4.3 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 EFW99528.1 - 0.68 9.2 9.9 0.42 9.9 7.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 EFW99528.1 - 0.92 9.5 5.7 6.2 6.8 0.6 3.6 1 1 1 3 3 3 0 Prefoldin subunit Lebercilin PF15619.6 EFW99528.1 - 0.95 9.1 10.7 0.15 11.7 3.8 2.7 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 EFW99528.1 - 0.99 10.1 16.0 1.3 9.6 4.1 3.4 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FH2 PF02181.23 EFW99528.1 - 1.1 8.4 5.7 2.6 7.1 2.5 2.7 2 1 1 3 3 3 0 Formin Homology 2 Domain TMPIT PF07851.13 EFW99528.1 - 1.1 8.4 2.2 2.7 7.2 2.1 1.7 1 1 0 1 1 1 0 TMPIT-like protein Sec2p PF06428.11 EFW99528.1 - 1.2 9.1 7.5 1.7 8.7 0.6 3.4 2 1 1 4 4 3 0 GDP/GTP exchange factor Sec2p Cluap1 PF10234.9 EFW99528.1 - 1.4 8.3 6.0 2.9 7.2 5.8 1.6 1 1 0 1 1 1 0 Clusterin-associated protein-1 DUF724 PF05266.14 EFW99528.1 - 1.6 8.6 6.1 14 5.4 3.5 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF724) Syntaxin-6_N PF09177.11 EFW99528.1 - 1.7 9.2 7.2 0.23 12.1 1.7 2.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Tmemb_cc2 PF10267.9 EFW99528.1 - 2.1 7.4 10.2 0.38 9.8 4.7 2.3 2 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein SKA2 PF16740.5 EFW99528.1 - 2.2 8.1 6.2 10 6.0 2.7 2.8 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Fib_alpha PF08702.10 EFW99528.1 - 2.3 8.4 8.5 3.4 7.9 2.1 3.0 2 1 0 3 3 2 0 Fibrinogen alpha/beta chain family DUF4795 PF16043.5 EFW99528.1 - 3.2 7.3 7.2 1.6 8.3 3.9 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) Lectin_N PF03954.14 EFW99528.1 - 3.6 7.3 11.3 2.5 7.9 0.1 3.1 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain OmpH PF03938.14 EFW99528.1 - 4.1 7.8 13.0 0.37 11.1 3.7 2.7 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) CENP-F_leu_zip PF10473.9 EFW99528.1 - 6 6.9 12.5 0.34 10.9 1.2 3.5 2 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Leu_zip PF15294.6 EFW99528.1 - 6 6.3 8.6 2 7.9 3.4 2.2 1 1 1 2 2 2 0 Leucine zipper DUF4200 PF13863.6 EFW99528.1 - 6.3 7.2 9.8 5.4 7.4 1.1 3.2 2 1 1 3 3 2 0 Domain of unknown function (DUF4200) BST2 PF16716.5 EFW99528.1 - 7.9 7.1 11.0 0.35 11.5 2.8 2.8 2 2 1 3 3 2 0 Bone marrow stromal antigen 2 Dynamitin PF04912.14 EFW99529.1 - 1.2e-91 307.9 0.0 1.6e-91 307.5 0.0 1.1 1 0 0 1 1 1 1 Dynamitin Adaptin_binding PF10199.9 EFW99529.1 - 0.0066 17.0 0.0 0.16 12.6 0.0 2.6 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Spc7 PF08317.11 EFW99529.1 - 0.033 13.1 3.2 0.4 9.5 0.2 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF1127 PF06568.11 EFW99529.1 - 0.11 12.2 11.9 0.29 10.9 0.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1127) ZapB PF06005.12 EFW99529.1 - 0.14 12.7 8.6 1.5 9.3 2.2 3.5 3 0 0 3 3 3 0 Cell division protein ZapB GrpE PF01025.19 EFW99529.1 - 0.25 11.0 6.1 0.66 9.6 3.3 2.5 2 1 0 2 2 2 0 GrpE ATP-synt_E PF05680.12 EFW99529.1 - 0.26 11.6 8.3 0.089 13.1 3.8 2.3 2 0 0 2 2 2 0 ATP synthase E chain Sipho_Gp157 PF05565.11 EFW99529.1 - 0.35 10.9 6.7 0.37 10.8 0.0 3.0 3 0 0 3 3 3 0 Siphovirus Gp157 HemX PF04375.14 EFW99529.1 - 0.83 8.9 8.8 0.43 9.8 0.3 2.7 3 0 0 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2203 PF09969.9 EFW99529.1 - 1.4 9.7 7.5 48 4.7 1.5 3.5 4 0 0 4 4 3 0 Uncharacterized conserved protein (DUF2203) DivIC PF04977.15 EFW99529.1 - 2.1 8.1 14.2 1.6 8.6 0.4 3.5 3 0 0 3 3 3 0 Septum formation initiator Tropomyosin_1 PF12718.7 EFW99529.1 - 2.2 8.4 13.5 0.51 10.5 4.6 3.0 3 0 0 3 3 3 0 Tropomyosin like zf_C2H2_10 PF18414.1 EFW99529.1 - 2.5 7.7 3.4 60 3.3 0.1 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger CREPT PF16566.5 EFW99529.1 - 3.2 7.9 8.2 4.9 7.3 0.3 3.6 5 0 0 5 5 5 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.8 EFW99529.1 - 3.7 7.6 11.2 1.7 8.7 3.6 2.9 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding MRPL52 PF18699.1 EFW99529.1 - 4 7.7 8.4 1 9.6 4.8 2.0 2 1 0 2 2 2 0 Mitoribosomal protein mL52 DUF1192 PF06698.11 EFW99529.1 - 4.8 7.3 27.4 1.6 8.9 2.4 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) Lebercilin PF15619.6 EFW99529.1 - 6.1 6.5 12.6 0.17 11.5 5.1 2.1 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Ribosomal_S8 PF00410.19 EFW99530.1 - 8.3e-14 51.6 0.0 3.1e-13 49.8 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein S8 PP2C PF00481.21 EFW99531.1 - 1.7e-57 195.0 0.0 2.9e-57 194.3 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EFW99531.1 - 2.8e-38 129.5 52.5 1.1e-09 37.9 0.3 9.3 5 2 6 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 EFW99531.1 - 1.2e-33 114.6 69.1 0.00041 20.7 0.1 13.4 5 4 7 15 15 15 12 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EFW99531.1 - 1.5e-28 99.7 0.0 4.2e-27 95.0 0.0 2.2 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ad_cyc_g-alpha PF08509.11 EFW99531.1 - 7e-20 70.5 0.7 1.8e-19 69.2 0.7 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_9 PF14580.6 EFW99531.1 - 2.7e-05 23.8 21.3 0.087 12.3 0.6 4.7 2 1 3 5 5 5 3 Leucine-rich repeat Ribosomal_L10 PF00466.20 EFW99532.1 - 1.9e-23 82.4 0.2 6.1e-23 80.9 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFW99532.1 - 5.2e-22 77.6 0.0 9.4e-22 76.8 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EFW99532.1 - 1.9e-17 63.6 4.9 1.9e-17 63.6 4.9 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein ATP-synt_ab PF00006.25 EFW99533.1 - 3.4e-23 82.4 0.0 5.2e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFW99533.1 - 3e-15 56.5 2.9 6.5e-15 55.4 2.9 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RbcS PF12338.8 EFW99533.1 - 0.52 10.5 5.4 1.5 9.1 0.2 3.2 3 0 0 3 3 3 0 Ribulose-1,5-bisphosphate carboxylase small subunit PKD_channel PF08016.12 EFW99534.1 - 0.13 11.0 7.4 1.5 7.4 0.3 2.2 2 0 0 2 2 2 0 Polycystin cation channel DUF5446 PF17522.2 EFW99534.1 - 0.5 10.6 2.7 1.1 9.5 2.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5446) LETM1 PF07766.13 EFW99535.1 - 6.4e-106 353.6 0.9 9.2e-106 353.1 0.9 1.2 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.27 EFW99535.1 - 0.00023 20.8 0.2 0.016 15.0 0.0 3.4 4 0 0 4 4 4 1 SAP domain OEP PF02321.18 EFW99535.1 - 0.27 11.0 6.5 0.74 9.6 6.5 1.7 1 0 0 1 1 1 0 Outer membrane efflux protein DEAD PF00270.29 EFW99536.1 - 3e-11 43.4 0.0 8.7e-11 41.9 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW99536.1 - 2.3e-07 31.2 0.0 6e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99536.1 - 0.16 11.9 0.0 0.39 10.7 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Pkinase PF00069.25 EFW99537.1 - 9.9e-46 156.2 0.0 8.3e-36 123.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99537.1 - 4.2e-17 62.3 0.0 3.3e-16 59.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFW99537.1 - 0.0091 15.9 2.9 0.68 9.8 0.2 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 EFW99537.1 - 1.4 8.5 6.0 0.2 11.3 0.3 2.4 2 1 0 2 2 2 0 RIO1 family MRG PF05712.13 EFW99538.1 - 4.1e-34 117.6 0.3 1e-33 116.3 0.0 1.7 2 0 0 2 2 2 1 MRG Tudor-knot PF11717.8 EFW99538.1 - 9.6e-05 22.2 1.7 0.00024 20.9 1.7 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF3439 PF11921.8 EFW99541.1 - 8.3 6.4 15.7 22 5.1 15.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DNApol_Exo PF18136.1 EFW99542.1 - 1.9e-101 338.9 0.0 3.3e-101 338.2 0.0 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EFW99542.1 - 2.3e-51 175.0 0.0 3.5e-51 174.4 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family A PCI PF01399.27 EFW99543.1 - 9.8e-11 42.1 0.0 2.4e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 PCI domain WD40 PF00400.32 EFW99543.1 - 0.00014 22.6 9.2 0.89 10.5 0.3 5.9 6 1 0 6 6 6 2 WD domain, G-beta repeat RPN7 PF10602.9 EFW99543.1 - 0.0013 18.4 0.1 0.0037 17.0 0.1 1.8 1 0 0 1 1 1 1 26S proteasome subunit RPN7 DUF3731 PF12531.8 EFW99543.1 - 0.11 12.3 1.3 14 5.4 0.2 2.5 2 0 0 2 2 2 0 DNA-K related protein Nup192 PF11894.8 EFW99544.1 - 0 1370.3 0.1 0 1370.1 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Ribosomal_S28e PF01200.18 EFW99545.1 - 6e-27 93.4 0.9 9.3e-27 92.8 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S28e ThiS PF02597.20 EFW99545.1 - 6.5e-07 29.9 0.0 1.6e-06 28.7 0.0 1.7 1 1 0 1 1 1 1 ThiS family IBR PF01485.21 EFW99546.1 - 6.1e-10 39.2 21.5 7.5e-07 29.3 4.3 3.4 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain Cullin PF00888.22 EFW99547.1 - 1.2e-184 615.4 0.0 2.1e-184 614.6 0.0 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EFW99547.1 - 1e-24 86.4 1.9 2.9e-24 84.9 1.4 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain IF4E PF01652.18 EFW99548.1 - 1.8e-54 183.8 0.2 2.3e-54 183.5 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DnaJ_C PF01556.18 EFW99549.1 - 1.1e-37 129.4 0.1 1.4e-37 129.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFW99549.1 - 1.6e-26 92.2 2.8 2.6e-26 91.5 2.8 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFW99549.1 - 2.4e-16 59.8 17.9 5e-16 58.8 17.9 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFW99549.1 - 0.068 13.1 17.0 0.055 13.4 3.5 2.6 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zinc_ribbon_9 PF14369.6 EFW99549.1 - 0.078 13.3 0.4 22 5.4 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon DUF2614 PF11023.8 EFW99549.1 - 0.38 10.9 6.4 4.6 7.4 1.0 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain HypA PF01155.19 EFW99549.1 - 0.99 9.4 9.7 1.1 9.3 2.4 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EFW99549.1 - 1.1 9.3 7.4 7.3 6.7 1.8 2.5 1 1 1 2 2 2 0 zinc-ribbons UIM PF02809.20 EFW99550.1 - 0.17 11.8 0.6 0.52 10.4 0.6 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF1765 PF08578.10 EFW99551.1 - 4.4e-46 156.4 0.2 8.6e-46 155.5 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) PGAP1 PF07819.13 EFW99551.1 - 2.1e-10 40.7 0.0 6.8e-10 39.1 0.0 1.8 1 0 0 1 1 1 1 PGAP1-like protein ANAPC4_WD40 PF12894.7 EFW99551.1 - 1.2e-05 25.5 0.0 3.2 8.1 0.0 4.8 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFW99551.1 - 5.5e-05 23.9 0.3 0.09 13.7 0.0 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF676 PF05057.14 EFW99551.1 - 8e-05 22.2 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DKCLD PF08068.12 EFW99551.1 - 0.027 14.5 0.1 0.063 13.4 0.1 1.6 1 0 0 1 1 1 0 DKCLD (NUC011) domain Ank_2 PF12796.7 EFW99552.1 - 2.2e-20 73.0 2.2 1.9e-12 47.6 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFW99552.1 - 9.7e-13 47.9 0.1 0.0062 16.9 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFW99552.1 - 7.7e-10 39.1 0.1 6.3e-06 26.6 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW99552.1 - 8.3e-10 38.1 0.1 0.04 14.5 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFW99552.1 - 0.0006 20.1 0.3 0.32 11.4 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Shikimate_DH PF01488.20 EFW99552.1 - 0.004 17.2 0.0 0.0073 16.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pga1 PF10333.9 EFW99553.1 - 0.0061 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator fn3 PF00041.21 EFW99553.1 - 0.058 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III domain L51_S25_CI-B8 PF05047.16 EFW99554.1 - 7.8e-15 54.5 0.1 1.2e-14 53.9 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain SPT2 PF08243.11 EFW99555.1 - 7.9e-09 36.0 28.3 2.3e-07 31.3 28.3 2.5 1 1 0 1 1 1 1 SPT2 chromatin protein DUF3381 PF11861.8 EFW99555.1 - 0.027 14.3 3.1 0.062 13.1 3.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) AreA_N PF07573.11 EFW99555.1 - 0.86 10.3 8.3 0.43 11.3 1.0 2.8 2 0 0 2 2 2 0 Nitrogen regulatory protein AreA N terminus SNARE_assoc PF09335.11 EFW99556.1 - 4.8e-15 56.1 4.6 4.8e-15 56.1 4.6 2.3 1 1 1 2 2 2 1 SNARE associated Golgi protein DUF543 PF04418.12 EFW99556.1 - 4.2 7.4 5.1 37 4.4 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF543) zf-RING-like PF08746.11 EFW99557.1 - 0.0098 16.2 0.3 0.023 15.0 0.3 1.6 1 0 0 1 1 1 1 RING-like domain PHD PF00628.29 EFW99557.1 - 0.017 15.0 2.8 0.052 13.4 2.8 1.8 1 0 0 1 1 1 0 PHD-finger Gp49 PF05973.14 EFW99557.1 - 0.083 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) DUF3827 PF12877.7 EFW99557.1 - 0.77 8.1 3.0 0.38 9.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3827) FANCL_C PF11793.8 EFW99557.1 - 1.1 9.4 6.1 0.28 11.4 1.3 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING_2 PF13639.6 EFW99557.1 - 4.1 7.8 6.9 4.5 7.7 1.7 2.5 2 0 0 2 2 2 0 Ring finger domain F_actin_cap_B PF01115.17 EFW99558.1 - 9.1e-100 333.2 0.0 1.6e-99 332.4 0.0 1.4 1 0 0 1 1 1 1 F-actin capping protein, beta subunit SNF2_N PF00176.23 EFW99558.1 - 6.7e-52 176.3 0.0 1e-51 175.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFW99558.1 - 1.5e-15 57.5 0.5 4.8e-15 55.9 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFW99558.1 - 0.015 14.5 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase ABC2_membrane PF01061.24 EFW99559.1 - 1.4e-69 233.8 50.8 1.9e-34 118.9 19.3 3.7 3 1 1 4 4 4 3 ABC-2 type transporter ABC_tran PF00005.27 EFW99559.1 - 2.1e-37 128.7 0.0 2.5e-18 66.9 0.0 2.3 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFW99559.1 - 1.9e-28 98.2 0.1 1.7e-25 88.8 0.0 2.8 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EFW99559.1 - 5.4e-09 36.6 0.6 1.5e-08 35.2 0.1 2.0 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_16 PF13191.6 EFW99559.1 - 3.1e-06 27.7 0.3 0.00056 20.3 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EFW99559.1 - 1.1e-05 25.0 0.0 0.0045 16.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.7 EFW99559.1 - 1.2e-05 24.7 14.2 1.2e-05 24.7 14.2 2.7 3 0 0 3 3 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFW99559.1 - 0.00015 21.7 0.1 0.004 17.1 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EFW99559.1 - 0.00065 19.9 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFW99559.1 - 0.0012 18.5 0.2 0.085 12.6 0.1 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EFW99559.1 - 0.0018 18.8 0.0 2.8 8.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFW99559.1 - 0.0046 17.2 0.4 0.98 9.7 0.2 2.9 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFW99559.1 - 0.0071 16.6 1.0 1 9.6 0.4 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFW99559.1 - 0.03 13.9 1.3 1.6 8.3 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EFW99559.1 - 0.05 13.3 0.3 5.6 6.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EFW99559.1 - 0.061 13.1 0.0 7.5 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 EFW99559.1 - 0.075 12.3 0.1 4.4 6.5 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin DUF3938 PF13074.6 EFW99559.1 - 2.9 8.2 6.7 3.4 8.0 0.3 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF3938) MFS_1 PF07690.16 EFW99560.1 - 1.1e-33 116.7 18.8 1.1e-33 116.7 18.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFW99560.1 - 0.00019 20.8 0.1 0.00019 20.8 0.1 2.4 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB CLN3 PF02487.17 EFW99560.1 - 0.26 10.3 5.2 1.9 7.5 0.7 2.3 2 0 0 2 2 2 0 CLN3 protein Coatomer_WDAD PF04053.14 EFW99561.1 - 3.1e-169 563.7 0.0 4.6e-169 563.2 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 EFW99561.1 - 2.6e-35 119.8 8.0 1e-05 26.2 0.0 8.4 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99561.1 - 4.7e-07 30.0 0.2 4 7.8 0.0 6.0 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFW99561.1 - 5.7e-05 22.0 0.8 0.3 9.7 0.1 3.4 1 1 2 3 3 3 3 Nucleoporin Nup120/160 MetallophosC PF16370.5 EFW99561.1 - 0.046 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase Cys_Met_Meta_PP PF01053.20 EFW99562.1 - 1.1e-117 392.8 0.1 3.9e-98 328.5 0.0 2.0 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFW99562.1 - 0.00069 18.7 0.2 0.001 18.1 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFW99562.1 - 0.0027 17.1 1.1 0.0077 15.6 1.0 1.8 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EFW99562.1 - 0.08 12.1 0.1 0.31 10.2 0.0 1.5 1 1 0 1 1 1 0 Aminotransferase class I and II Auts2 PF15336.6 EFW99562.1 - 0.45 10.6 2.1 0.51 10.4 0.9 1.6 1 1 0 1 1 1 0 Autism susceptibility gene 2 protein GDPD PF03009.17 EFW99563.1 - 5.4e-68 229.5 0.0 1.7e-67 227.9 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_4 PF13637.6 EFW99563.1 - 1.9e-30 104.8 2.5 6.1e-10 39.4 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFW99563.1 - 1.9e-28 98.9 0.0 2.9e-09 37.4 0.3 4.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) SPX PF03105.19 EFW99563.1 - 8.1e-21 75.4 4.6 4.7e-10 39.9 0.0 3.5 2 1 1 3 3 3 3 SPX domain Ank_5 PF13857.6 EFW99563.1 - 1e-20 73.5 0.2 3.6e-06 27.1 0.0 6.1 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFW99563.1 - 7e-15 54.7 7.8 0.00018 21.8 0.1 6.8 7 0 0 7 7 7 2 Ankyrin repeat Ank_3 PF13606.6 EFW99563.1 - 1e-14 53.2 5.4 0.0076 16.7 0.0 7.4 7 0 0 7 7 7 2 Ankyrin repeat RmlD_sub_bind PF04321.17 EFW99565.1 - 1.5e-57 194.9 0.0 2.1e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EFW99565.1 - 3.5e-25 88.9 0.0 4.6e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFW99565.1 - 4.7e-11 42.7 0.0 1.5e-10 41.0 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFW99565.1 - 7e-10 38.5 0.4 1.1e-07 31.3 0.4 2.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFW99565.1 - 4.5e-09 35.7 0.1 2.8e-08 33.1 0.1 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFW99565.1 - 8.7e-08 31.6 0.1 5.1e-06 25.9 0.0 2.3 1 1 0 2 2 2 1 Male sterility protein DapB_N PF01113.20 EFW99565.1 - 0.01 16.0 0.1 0.026 14.6 0.1 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 EFW99565.1 - 0.012 15.2 1.5 0.55 9.7 0.3 2.8 2 1 0 2 2 2 0 NmrA-like family Semialdhyde_dh PF01118.24 EFW99565.1 - 0.026 15.0 0.0 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 EFW99565.1 - 0.083 13.0 0.7 3.6 7.7 0.2 2.6 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DRIM PF07539.12 EFW99566.1 - 1.7e-182 608.0 0.0 4.6e-182 606.6 0.0 1.8 1 0 0 1 1 1 1 Down-regulated in metastasis HEAT PF02985.22 EFW99566.1 - 0.036 14.3 23.6 0.68 10.3 0.0 8.2 7 1 1 8 8 7 0 HEAT repeat SAGA-Tad1 PF12767.7 EFW99566.1 - 0.041 13.6 1.3 0.067 12.9 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF913 PF06025.12 EFW99566.1 - 0.08 11.9 5.3 0.13 11.2 1.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF2052 PF09747.9 EFW99566.1 - 0.11 12.7 19.5 0.022 14.9 3.8 3.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) SpoIIIAH PF12685.7 EFW99566.1 - 0.14 12.0 7.0 0.11 12.3 2.7 2.6 2 0 0 2 2 2 0 SpoIIIAH-like protein HEAT_2 PF13646.6 EFW99566.1 - 0.21 12.0 25.7 1.8 9.0 0.3 8.3 8 1 0 8 8 8 0 HEAT repeats Tim54 PF11711.8 EFW99566.1 - 0.36 9.6 6.4 0.76 8.5 6.4 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SMN PF06003.12 EFW99566.1 - 0.48 9.6 2.6 1 8.5 2.6 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) GramPos_pilinD1 PF16555.5 EFW99566.1 - 1.3 9.2 5.7 3 8.0 5.7 1.5 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain DUF2151 PF10221.9 EFW99566.1 - 1.3 7.5 3.0 2.7 6.5 3.0 1.4 1 0 0 1 1 1 0 Cell cycle and development regulator Nop14 PF04147.12 EFW99566.1 - 5.1 5.2 21.4 0.24 9.6 8.8 2.4 2 0 0 2 2 2 0 Nop14-like family Afi1 PF07792.12 EFW99566.1 - 5.4 7.5 9.8 3.1 8.3 3.2 2.7 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking zf-C3HC4_3 PF13920.6 EFW99567.1 - 4.4e-11 42.5 7.2 6.3e-11 42.0 7.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFW99567.1 - 1.5e-07 31.1 7.0 2.5e-07 30.4 7.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFW99567.1 - 1.7e-07 31.0 9.1 2.6e-07 30.4 9.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFW99567.1 - 1.2e-06 28.8 7.7 1.8e-06 28.2 7.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFW99567.1 - 1.2e-06 28.3 8.2 1.9e-06 27.7 8.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFW99567.1 - 2e-06 27.7 5.2 1.1e-05 25.3 2.0 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFW99567.1 - 4.9e-06 26.3 8.1 7.7e-06 25.7 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFW99567.1 - 7.6e-05 22.7 2.9 0.00013 21.9 2.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EFW99567.1 - 0.0018 18.4 7.7 0.0031 17.6 7.7 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EFW99567.1 - 0.0072 16.6 4.1 0.014 15.7 4.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EFW99567.1 - 0.31 10.8 5.8 0.54 10.1 5.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EFW99567.1 - 0.43 10.4 8.8 0.15 11.9 4.6 2.1 2 0 0 2 2 2 0 RING-like zinc finger SIL1 PF16782.5 EFW99568.1 - 8.2e-09 35.1 0.0 1.4e-08 34.3 0.0 1.4 2 0 0 2 2 2 1 Nucleotide exchange factor SIL1 Citrate_bind PF16114.5 EFW99569.1 - 1.7e-87 291.5 0.1 2.4e-87 291.0 0.1 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EFW99569.1 - 4.7e-08 32.8 0.0 7.4e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Reovirus_M2 PF05993.12 EFW99569.1 - 0.019 13.1 0.0 0.027 12.6 0.0 1.1 1 0 0 1 1 1 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) Pro_isomerase PF00160.21 EFW99570.1 - 2.5e-41 141.6 0.0 5.3e-41 140.5 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4604 PF15377.6 EFW99570.1 - 0.0033 17.9 0.0 0.0033 17.9 0.0 3.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4604) XAP5 PF04921.14 EFW99570.1 - 0.044 13.6 2.5 0.1 12.4 2.5 1.7 1 0 0 1 1 1 0 XAP5, circadian clock regulator Glyco_hydro_72 PF03198.14 EFW99571.1 - 5.4e-116 387.3 0.0 6.9e-116 386.9 0.0 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 EFW99571.1 - 0.0088 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain MFS_1 PF07690.16 EFW99572.1 - 4.4e-30 104.8 37.6 6.1e-30 104.3 37.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily VPS28 PF03997.12 EFW99573.1 - 5.2e-64 215.4 0.0 6.6e-64 215.1 0.0 1.1 1 0 0 1 1 1 1 VPS28 protein PX PF00787.24 EFW99575.1 - 8.3e-18 64.4 0.0 1.3e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 PX domain Pro_isomerase PF00160.21 EFW99576.1 - 2.3e-40 138.5 0.0 2.8e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DnaJ_C PF01556.18 EFW99577.1 - 3.2e-21 76.0 0.0 4.1e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EFW99577.1 - 0.0002 21.7 4.9 0.0002 21.7 4.9 1.6 2 0 0 2 2 2 1 DnaJ central domain Biotin_lipoyl_2 PF13533.6 EFW99577.1 - 0.33 10.8 1.3 2.5 8.0 0.1 2.7 3 0 0 3 3 3 0 Biotin-lipoyl like Ferritin_2 PF13668.6 EFW99578.1 - 1.2e-37 129.2 0.0 2.3e-37 128.2 0.0 1.5 1 0 0 1 1 1 1 Ferritin-like domain LIME1 PF15332.6 EFW99578.1 - 0.15 11.6 1.4 0.82 9.2 1.3 1.9 2 0 0 2 2 2 0 Lck-interacting transmembrane adapter 1 DUF3425 PF11905.8 EFW99580.1 - 2.1e-15 56.8 0.0 4.4e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Glyco_transf_22 PF03901.17 EFW99581.1 - 5e-38 131.4 6.7 8.4e-38 130.7 6.7 1.4 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family RRM_1 PF00076.22 EFW99582.1 - 1.9e-22 78.9 0.0 2.7e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFW99582.1 - 0.014 15.5 0.3 0.033 14.3 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif PH_10 PF15411.6 EFW99583.1 - 9.6e-30 103.4 0.2 1.6e-29 102.6 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 EFW99583.1 - 3e-13 50.4 0.0 4.6e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFW99583.1 - 1.6e-09 37.9 0.3 1.3e-08 35.0 0.1 2.5 2 1 0 2 2 2 1 von Willebrand factor type A domain zf-RING_2 PF13639.6 EFW99583.1 - 0.00011 22.5 5.2 0.00019 21.7 5.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFW99583.1 - 0.0012 18.8 5.6 0.002 18.1 5.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFW99583.1 - 0.0045 16.8 4.1 0.0087 15.9 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFW99583.1 - 0.0054 17.0 2.5 0.013 15.8 2.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EFW99583.1 - 0.0065 16.1 2.5 0.0065 16.1 2.5 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EFW99583.1 - 0.01 15.7 2.4 0.02 14.7 2.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFW99583.1 - 0.017 15.0 4.7 0.032 14.1 4.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.29 EFW99583.1 - 0.024 15.1 0.0 0.064 13.8 0.0 1.6 1 0 0 1 1 1 0 PH domain zf-RING-like PF08746.11 EFW99583.1 - 0.069 13.5 4.0 0.13 12.6 4.0 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_11 PF17123.5 EFW99583.1 - 0.098 12.4 3.6 0.23 11.2 3.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger DUF1147 PF06615.11 EFW99583.1 - 0.14 12.2 0.4 0.43 10.7 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) zf-C3H2C3 PF17122.5 EFW99583.1 - 0.69 10.0 4.2 1.6 8.8 4.2 1.7 1 1 0 1 1 1 0 Zinc-finger Prok-RING_4 PF14447.6 EFW99583.1 - 1.5 8.8 3.9 2.7 7.9 3.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 EFW99583.1 - 2.6 8.1 5.1 7.8 6.5 0.6 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.6 EFW99583.1 - 4 7.5 5.5 12 6.0 5.5 1.9 1 0 0 1 1 1 0 RING-type zinc-finger MRP-L46 PF11788.8 EFW99584.1 - 1.1e-23 84.3 0.0 2.6e-23 83.0 0.0 1.7 1 1 0 1 1 1 1 39S mitochondrial ribosomal protein L46 CwfJ_C_1 PF04677.15 EFW99585.1 - 1.9e-25 89.1 0.0 4.5e-24 84.7 0.0 2.3 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EFW99585.1 - 1.2e-13 51.8 0.4 2.1e-13 51.0 0.4 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Trehalase_Ca-bi PF07492.11 EFW99585.1 - 0.058 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Neutral trehalase Ca2+ binding domain Fungal_lectin PF07938.12 EFW99586.1 - 0.00082 18.9 0.0 1.1 8.5 0.0 2.8 1 1 1 3 3 3 2 Fungal fucose-specific lectin THF_DHG_CYH PF00763.23 EFW99587.1 - 2.3e-26 92.4 0.0 3.4e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EFW99587.1 - 2.9e-13 49.5 0.1 2.2e-08 33.6 0.0 2.6 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain U1snRNP70_N PF12220.8 EFW99588.1 - 3e-27 95.1 2.6 5.4e-27 94.3 1.7 1.9 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EFW99588.1 - 2.7e-16 59.1 0.1 9.1e-16 57.5 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFW99588.1 - 0.00016 21.7 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif dCMP_cyt_deam_1 PF00383.23 EFW99589.1 - 3.2e-16 59.1 0.0 5.1e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFW99589.1 - 3.2e-11 43.1 0.0 4.1e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EFW99589.1 - 0.022 14.8 1.1 0.31 11.1 0.4 2.2 1 1 1 2 2 2 0 Bd3614-like deaminase APOBEC2 PF18772.1 EFW99589.1 - 0.036 14.1 0.1 0.98 9.5 0.1 2.1 1 1 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 EFW99589.1 - 0.04 14.0 0.0 1.5 8.9 0.0 2.1 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 Fcf1 PF04900.12 EFW99590.1 - 1.2e-33 115.4 0.1 3.2e-33 114.0 0.1 1.8 1 0 0 1 1 1 1 Fcf1 PP2C_2 PF13672.6 EFW99590.1 - 0.0001 22.0 0.1 0.00021 21.0 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EFW99590.1 - 0.0028 17.6 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) SGT1 PF07093.11 EFW99590.1 - 0.03 12.8 2.6 0.051 12.0 2.6 1.3 1 0 0 1 1 1 0 SGT1 protein CDC45 PF02724.14 EFW99590.1 - 0.35 9.1 10.1 0.67 8.2 10.1 1.3 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EFW99590.1 - 2.2 8.4 21.9 0.18 11.9 16.5 1.8 2 0 0 2 2 2 0 YL1 nuclear protein LYRIC PF15686.5 EFW99590.1 - 9.2 5.7 20.7 15 5.0 20.7 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Ribosomal_L21p PF00829.21 EFW99591.1 - 1.9e-13 50.5 0.1 9.8e-13 48.2 0.1 1.9 1 1 0 1 1 1 1 Ribosomal prokaryotic L21 protein FlgT_C PF16538.5 EFW99591.1 - 0.43 11.1 1.4 14 6.3 0.0 3.0 3 0 0 3 3 3 0 Flagellar assembly protein T, C-terminal domain Mannosyl_trans3 PF11051.8 EFW99593.1 - 3.3e-54 184.1 0.0 1.1e-32 113.6 0.0 2.5 2 0 0 2 2 2 2 Mannosyltransferase putative Citrate_synt PF00285.21 EFW99594.1 - 8.7e-21 74.4 0.0 1.7e-17 63.6 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 EFW99594.1 - 4.1e-19 69.1 0.0 1.9e-18 67.0 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EFW99594.1 - 3.4e-14 52.9 0.1 5.6e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EFW99594.1 - 9.1e-05 22.3 0.1 0.00048 19.9 0.0 2.1 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EFW99594.1 - 0.09 13.3 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain RTC4 PF14474.6 EFW99595.1 - 3.5e-34 117.6 0.0 6.4e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Rad50_zn_hook PF04423.14 EFW99595.1 - 0.13 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Rad50 zinc hook motif ChaC PF04752.12 EFW99596.1 - 4.6e-45 153.9 0.1 1.7e-44 152.1 0.1 1.7 1 1 0 1 1 1 1 ChaC-like protein tRNA-synt_1g PF09334.11 EFW99597.1 - 9.9e-66 222.1 1.3 1.6e-37 129.2 0.2 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Acetyltransf_1 PF00583.25 EFW99597.1 - 6e-12 45.8 0.0 1.9e-11 44.2 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFW99597.1 - 5.7e-06 26.3 0.1 1.1e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFW99597.1 - 8.8e-06 26.1 0.0 3.2e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFW99597.1 - 4.5e-05 23.3 0.9 0.00014 21.7 0.1 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.7 EFW99597.1 - 0.0046 17.0 1.4 0.061 13.4 0.1 3.1 4 0 0 4 4 4 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EFW99597.1 - 0.11 12.5 0.3 0.46 10.5 0.1 2.1 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase DUF2406 PF10295.9 EFW99598.1 - 1.9e-24 86.1 0.1 1.9e-24 86.1 0.1 2.2 2 1 0 2 2 2 1 Uncharacterised protein (DUF2406) PX PF00787.24 EFW99599.1 - 3.6e-20 72.0 0.6 8.7e-20 70.8 0.0 1.9 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 EFW99599.1 - 3.5e-09 36.6 6.4 2.3e-05 24.1 0.3 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 EFW99599.1 - 3.9e-05 23.4 6.6 0.0011 18.7 0.7 2.1 2 0 0 2 2 2 2 BAR domain BAR_3 PF16746.5 EFW99599.1 - 0.02 14.6 0.6 0.52 10.0 0.1 2.2 2 0 0 2 2 2 0 BAR domain of APPL family TerB PF05099.13 EFW99599.1 - 0.059 13.3 8.4 3 7.8 1.6 3.2 3 0 0 3 3 3 0 Tellurite resistance protein TerB UPF0242 PF06785.11 EFW99599.1 - 1.1 9.4 8.1 8 6.5 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus RNA_pol_Rbc25 PF08292.12 EFW99601.1 - 3.3e-26 92.0 1.1 9.3e-26 90.6 1.1 1.7 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EFW99601.1 - 3.5e-13 49.7 0.0 7.4e-13 48.7 0.0 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Xrn1_D3 PF18194.1 EFW99601.1 - 0.014 15.4 0.1 0.022 14.9 0.1 1.2 1 0 0 1 1 1 0 Exoribonuclease 1 Domain-3 BTB PF00651.31 EFW99602.1 - 1.4e-05 25.2 0.0 3.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain EF-hand_7 PF13499.6 EFW99603.1 - 7.1e-18 64.8 8.4 1.5e-07 31.7 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFW99603.1 - 9.6e-18 62.5 13.3 2.4e-05 23.9 0.0 5.3 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.32 EFW99603.1 - 1.6e-17 61.6 19.9 7.5e-07 28.3 0.0 5.7 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 EFW99603.1 - 1.1e-10 41.1 13.7 0.00033 20.4 0.0 4.1 3 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFW99603.1 - 1.9e-09 36.6 12.5 1.2e-05 24.5 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_2 PF09068.11 EFW99603.1 - 0.065 13.4 0.0 0.39 10.9 0.0 2.6 1 1 0 1 1 1 0 EF hand Scm3 PF10384.9 EFW99603.1 - 0.086 12.6 0.3 14 5.5 0.0 2.4 2 0 0 2 2 2 0 Centromere protein Scm3 TFIIA PF03153.13 EFW99603.1 - 2.1 8.3 6.6 2.6 7.9 6.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SET PF00856.28 EFW99604.1 - 1.4e-12 48.3 0.0 4.1e-12 46.8 0.0 1.8 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 EFW99604.1 - 6.7e-09 35.7 12.8 6.7e-09 35.7 12.8 2.0 2 0 0 2 2 2 1 MYND finger Clathrin PF00637.20 EFW99605.1 - 8.7e-196 641.7 32.7 3.5e-32 111.2 3.7 7.6 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EFW99605.1 - 2.7e-31 106.3 0.1 7.4e-06 26.0 0.1 6.6 6 0 0 6 6 6 4 Clathrin propeller repeat Clathrin_H_link PF13838.6 EFW99605.1 - 1.2e-28 98.8 0.1 7.4e-28 96.3 0.2 2.5 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 EFW99605.1 - 3.8e-05 23.0 2.3 9.2e-05 21.7 0.4 2.6 2 0 0 2 2 2 1 Clathrin, heavy-chain linker DUF4550 PF15084.6 EFW99605.1 - 0.021 15.2 0.3 5.1 7.6 0.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4550) TPR_14 PF13428.6 EFW99605.1 - 0.028 15.2 15.2 1.4 10.0 0.2 7.9 10 0 0 10 10 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFW99605.1 - 0.12 12.7 4.6 1.1 9.6 0.1 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR PF01535.20 EFW99605.1 - 0.3 11.4 2.8 11 6.6 0.0 4.8 5 0 0 5 5 4 0 PPR repeat Vps39_1 PF10366.9 EFW99605.1 - 0.47 10.8 6.6 1.3e+02 2.9 0.0 6.3 6 1 0 6 6 6 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 EFW99605.1 - 3.9 7.8 9.0 14 6.1 0.1 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFW99605.1 - 8.5 6.7 9.0 16 5.8 0.0 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat Hormone_4 PF00220.17 EFW99606.1 - 0.31 11.1 2.8 29 5.0 0.2 3.1 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Band_7 PF01145.25 EFW99607.1 - 3.2e-24 85.9 2.4 5.8e-24 85.1 2.4 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family UIM PF02809.20 EFW99607.1 - 0.21 11.6 1.8 0.56 10.2 1.8 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif CENP-Q PF13094.6 EFW99608.1 - 1.3e-50 171.9 1.2 1.7e-50 171.5 1.2 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF812 PF05667.11 EFW99608.1 - 0.014 14.3 0.1 0.019 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Vps5 PF09325.10 EFW99608.1 - 0.021 14.4 0.9 0.021 14.4 0.9 1.5 2 0 0 2 2 2 0 Vps5 C terminal like Spc7 PF08317.11 EFW99608.1 - 0.074 11.9 2.9 3.2 6.6 0.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Lectin_N PF03954.14 EFW99608.1 - 0.078 12.7 2.1 0.64 9.8 0.2 2.3 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Tropomyosin_1 PF12718.7 EFW99608.1 - 0.31 11.2 5.6 0.38 10.9 4.4 1.7 1 1 0 1 1 1 0 Tropomyosin like Mobilization_B PF17511.2 EFW99608.1 - 0.39 11.1 3.6 0.81 10.0 0.3 2.6 3 0 0 3 3 3 0 Mobilization protein B RmuC PF02646.16 EFW99608.1 - 0.42 9.7 4.0 1.1 8.4 1.2 2.1 2 0 0 2 2 2 0 RmuC family NPV_P10 PF05531.12 EFW99608.1 - 1.1 9.8 3.5 6.2 7.4 0.2 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ADIP PF11559.8 EFW99608.1 - 1.7 8.7 7.4 0.49 10.5 3.0 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding FUSC PF04632.12 EFW99608.1 - 7.3 5.0 8.8 5.3 5.4 7.2 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family CBS PF00571.28 EFW99609.1 - 2.1e-06 28.1 0.0 0.0068 16.8 0.0 2.3 2 0 0 2 2 2 2 CBS domain MDMPI_C PF07398.11 EFW99609.1 - 4 8.4 8.8 4.4 8.2 3.9 2.6 1 1 0 2 2 2 0 MDMPI C-terminal domain Sugar_tr PF00083.24 EFW99610.1 - 4.4e-94 315.9 24.7 5.4e-94 315.6 24.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFW99610.1 - 9.5e-20 70.8 25.4 9.5e-20 70.8 25.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFW99610.1 - 0.0006 18.4 1.0 0.0012 17.4 1.0 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 EFW99610.1 - 0.57 8.7 26.8 0.016 13.8 4.5 3.3 4 0 0 4 4 4 0 MFS/sugar transport protein CAF1 PF04857.20 EFW99611.1 - 5.6e-44 150.6 0.1 3.3e-33 115.2 0.0 2.0 1 1 1 2 2 2 2 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.20 EFW99611.1 - 0.0012 18.5 0.2 0.47 10.1 0.1 2.3 2 0 0 2 2 2 2 3'-5' exonuclease Zn_clus PF00172.18 EFW99612.1 - 2.3e-08 34.0 5.0 4.5e-08 33.1 5.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFW99612.1 - 2.4e-06 26.8 0.0 5.2e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain VASt PF16016.5 EFW99612.1 - 0.31 11.4 1.2 0.34 11.3 0.1 1.6 2 0 0 2 2 2 0 VAD1 Analog of StAR-related lipid transfer domain ATP-synt_ab_C PF00306.27 EFW99613.1 - 4.3e-48 162.8 0.4 6.6e-48 162.2 0.4 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab PF00006.25 EFW99613.1 - 3.5e-44 151.0 0.0 4.8e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Abhydrolase_1 PF00561.20 EFW99614.1 - 3e-12 46.8 0.0 4.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFW99614.1 - 4.4e-09 36.0 0.0 1.8e-08 33.9 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFW99614.1 - 0.00038 21.1 2.0 0.0011 19.7 0.9 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFW99614.1 - 0.00049 19.6 0.0 0.0018 17.8 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EFW99614.1 - 0.00067 19.4 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S15 PF02129.18 EFW99614.1 - 0.0056 16.3 0.0 0.0094 15.6 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Globin PF00042.22 EFW99615.1 - 5.9e-08 33.2 0.0 9.8e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Globin Protoglobin PF11563.8 EFW99615.1 - 0.00038 20.4 0.1 0.00057 19.8 0.1 1.3 1 0 0 1 1 1 1 Protoglobin FAD_binding_6 PF00970.24 EFW99615.1 - 0.012 15.9 0.0 0.047 14.0 0.0 1.9 1 1 0 1 1 1 0 Oxidoreductase FAD-binding domain EMC3_TMCO1 PF01956.16 EFW99616.1 - 6.3e-38 130.2 3.5 1.4e-36 125.8 3.5 2.2 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Pyr_redox_2 PF07992.14 EFW99617.1 - 5.2e-30 104.7 0.5 2.8e-26 92.4 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFW99617.1 - 7.9e-15 55.2 0.8 4.2e-11 43.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFW99617.1 - 6.3e-06 26.0 3.2 0.52 9.8 0.1 3.2 3 0 0 3 3 3 3 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFW99617.1 - 0.0019 17.4 0.0 0.0031 16.7 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFW99617.1 - 0.002 17.4 0.8 0.013 14.8 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFW99617.1 - 0.0046 15.9 2.7 0.7 8.7 0.0 2.9 2 1 1 3 3 3 2 Tryptophan halogenase NAD_binding_7 PF13241.6 EFW99617.1 - 0.011 16.2 0.3 0.63 10.5 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 EFW99617.1 - 0.084 13.1 0.3 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_2 PF00890.24 EFW99617.1 - 0.099 11.7 0.1 2.7 7.0 0.0 2.6 3 0 0 3 3 3 0 FAD binding domain Lycopene_cycl PF05834.12 EFW99617.1 - 0.13 11.2 0.6 0.86 8.6 0.0 2.3 2 1 1 3 3 3 0 Lycopene cyclase protein FSA_C PF10479.9 EFW99618.1 - 0.95 7.5 13.3 0.99 7.5 13.3 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Glyco_hydro_28 PF00295.17 EFW99620.1 - 3.7e-88 295.7 11.3 4.8e-88 295.3 11.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 SPC25 PF06703.11 EFW99621.1 - 2.7e-49 167.1 0.1 3.6e-49 166.7 0.1 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Amidase PF01425.21 EFW99622.1 - 3.2e-105 352.7 0.0 1e-104 351.0 0.0 1.7 1 1 0 1 1 1 1 Amidase zf-MYND PF01753.18 EFW99622.1 - 0.077 13.1 3.3 0.16 12.1 3.3 1.6 1 0 0 1 1 1 0 MYND finger DUF2399 PF09664.10 EFW99622.1 - 0.096 12.6 0.1 18 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2399) DUF410 PF04190.13 EFW99623.1 - 4.6e-91 305.1 0.0 5.5e-91 304.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) MutS_V PF00488.21 EFW99624.1 - 2.9e-68 229.6 0.0 5.5e-68 228.7 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFW99624.1 - 1.5e-45 155.8 6.8 2.7e-45 154.9 6.8 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EFW99624.1 - 5.1e-18 65.4 0.0 2.8e-17 63.0 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EFW99624.1 - 6.4e-08 33.0 0.0 1.8e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.6 EFW99624.1 - 0.035 13.8 0.1 0.088 12.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sporozoite_P67 PF05642.11 EFW99624.1 - 2.3 6.2 5.0 0.25 9.4 0.1 1.8 2 0 0 2 2 2 0 Sporozoite P67 surface antigen OB_NTP_bind PF07717.16 EFW99625.1 - 5.9e-21 74.6 0.0 1.1e-20 73.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFW99625.1 - 3.1e-19 69.2 0.0 6.7e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFW99625.1 - 2.6e-08 34.2 0.0 8.6e-07 29.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Meth_synt_2 PF01717.18 EFW99626.1 - 1.9e-153 510.5 0.0 2.3e-146 487.2 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EFW99626.1 - 7.3e-115 383.8 0.0 2.1e-108 362.6 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain Peptidase_M1 PF01433.20 EFW99627.1 - 0.00082 19.0 0.0 0.0041 16.7 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EFW99627.1 - 0.024 14.8 0.0 6.5 6.9 0.0 2.5 2 0 0 2 2 2 0 Peptidase M1 N-terminal domain Glutaredoxin PF00462.24 EFW99628.1 - 9.2e-14 51.4 0.0 2.7e-13 49.9 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin DUF4746 PF15928.5 EFW99628.1 - 0.12 11.8 0.1 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Herpes_UL25 PF01499.16 EFW99628.1 - 0.18 10.3 0.6 0.24 9.9 0.6 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family WD40 PF00400.32 EFW99629.1 - 0.00014 22.6 0.6 0.046 14.6 0.1 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF4259 PF14078.6 EFW99629.1 - 0.13 13.0 0.3 1.6 9.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) PAP1 PF08601.10 EFW99629.1 - 0.43 10.3 3.8 1.3 8.7 0.1 2.1 2 0 0 2 2 2 0 Transcription factor PAP1 PQQ_3 PF13570.6 EFW99629.1 - 1.7 9.2 4.1 12 6.5 0.0 4.0 4 1 0 4 4 4 0 PQQ-like domain HMG_box PF00505.19 EFW99630.1 - 1e-05 25.8 0.5 0.021 15.2 0.5 2.9 2 0 0 2 2 2 2 HMG (high mobility group) box ANAPC1 PF12859.7 EFW99630.1 - 0.093 13.3 1.2 0.28 11.7 1.2 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 1 TFIIF_alpha PF05793.12 EFW99630.1 - 1.4 7.4 35.0 2 6.9 35.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SlyX PF04102.12 EFW99630.1 - 8.7 7.0 7.1 4.5 8.0 1.8 2.9 2 1 1 3 3 3 0 SlyX AMP-binding PF00501.28 EFW99631.1 - 1.3e-68 231.5 0.0 1.9e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFW99631.1 - 1.1e-12 48.8 0.1 2.2e-12 47.8 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RRM_1 PF00076.22 EFW99633.1 - 1.3e-36 124.3 0.0 2.1e-17 62.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATG22 PF11700.8 EFW99634.1 - 1.7e-188 627.1 15.1 2e-188 626.9 15.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EFW99634.1 - 0.003 16.5 53.3 0.012 14.6 8.1 3.5 2 1 1 3 3 3 3 Major Facilitator Superfamily TRAP-gamma PF07074.12 EFW99634.1 - 0.02 14.4 0.7 0.074 12.6 0.7 1.9 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF4791 PF16039.5 EFW99634.1 - 0.58 9.7 10.7 0.45 10.0 2.8 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4791) Cpn60_TCP1 PF00118.24 EFW99635.1 - 2.1e-148 495.0 9.6 2.4e-148 494.8 9.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 EFW99635.1 - 0.0078 15.8 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 EAL domain DUF2204 PF09970.9 EFW99635.1 - 0.045 13.4 0.1 5.6 6.6 0.0 2.5 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) TetR_C_14 PF17754.1 EFW99635.1 - 0.057 13.4 0.7 2.1 8.3 0.2 2.5 2 0 0 2 2 2 0 MftR C-terminal domain Glyco_hydro_76 PF03663.14 EFW99636.1 - 3e-19 69.8 7.2 7.4e-13 48.7 1.4 3.4 3 1 0 3 3 3 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFW99636.1 - 0.0059 15.7 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 WD40 PF00400.32 EFW99637.1 - 3.7e-11 43.4 0.2 1.8e-05 25.4 0.1 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99637.1 - 1.6e-05 25.1 0.4 2.5 8.5 0.0 4.5 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_S11 PF00411.19 EFW99638.1 - 1.6e-07 31.7 0.0 3.5e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S11 ALF PF03752.13 EFW99638.1 - 0.064 13.2 5.2 0.15 12.0 0.3 2.6 2 0 0 2 2 2 0 Short repeats of unknown function Flp_N PF03930.14 EFW99638.1 - 0.084 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus BSP PF04450.12 EFW99638.1 - 0.1 12.3 0.0 0.85 9.4 0.0 2.2 2 1 0 2 2 2 0 Peptidase of plants and bacteria Glyco_hydro_38N PF01074.22 EFW99639.1 - 5.9e-86 288.4 0.9 1.1e-85 287.5 0.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFW99639.1 - 1.3e-52 179.0 0.1 5.9e-52 176.8 0.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFW99639.1 - 2.3e-26 91.8 0.0 5.9e-26 90.4 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EFW99639.1 - 2.1e-08 34.2 0.0 5e-07 29.7 0.0 2.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain HA2 PF04408.23 EFW99640.1 - 1.8e-21 76.4 0.0 1.8e-21 76.4 0.0 3.2 4 0 0 4 4 2 1 Helicase associated domain (HA2) Hep_59 PF07052.11 EFW99640.1 - 7.2e-19 68.5 2.5 1.1e-16 61.4 0.0 3.5 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 OB_NTP_bind PF07717.16 EFW99640.1 - 3.7e-17 62.5 0.0 9.2e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFW99640.1 - 8.6e-08 32.5 0.0 2.2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFW99640.1 - 2.5e-07 30.6 0.0 4.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFW99640.1 - 1.3e-05 25.5 0.1 4.6e-05 23.7 0.1 1.9 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EFW99640.1 - 0.00016 21.1 0.0 0.00042 19.7 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EFW99640.1 - 0.0015 18.9 0.2 0.0064 16.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFW99640.1 - 0.0024 17.0 0.0 0.0073 15.4 0.0 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 EFW99640.1 - 0.0033 17.4 0.0 0.94 9.5 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFW99640.1 - 0.0037 17.0 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFW99640.1 - 0.012 15.2 0.5 0.052 13.2 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ATPase PF06745.13 EFW99640.1 - 0.018 14.4 0.0 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 EFW99640.1 - 0.048 14.0 0.1 0.82 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Flavi_DEAD PF07652.14 EFW99640.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_14 PF13173.6 EFW99640.1 - 0.076 13.1 0.1 0.42 10.6 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFW99640.1 - 0.12 12.1 0.1 0.55 9.9 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_23 PF13476.6 EFW99640.1 - 0.12 12.8 1.4 2.7 8.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain PPR_2 PF13041.6 EFW99641.1 - 0.2 11.9 0.0 16 5.7 0.0 2.5 2 0 0 2 2 2 0 PPR repeat family Proteasome PF00227.26 EFW99643.1 - 1.2e-26 93.4 0.1 1.4e-25 89.9 0.1 2.0 1 1 0 1 1 1 1 Proteasome subunit Integrase_Zn PF02022.19 EFW99643.1 - 0.025 14.6 0.1 0.044 13.7 0.1 1.4 1 0 0 1 1 1 0 Integrase Zinc binding domain Phosphonate-bd PF12974.7 EFW99643.1 - 0.052 13.1 0.1 0.11 12.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein HLH PF00010.26 EFW99645.1 - 9e-12 44.8 3.2 2e-11 43.7 2.0 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF4776 PF16003.5 EFW99645.1 - 0.0054 15.8 1.2 0.0083 15.2 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4776) Phage_GPO PF05929.11 EFW99645.1 - 0.017 14.8 1.7 0.023 14.3 1.0 1.5 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase YabA PF06156.13 EFW99645.1 - 0.027 15.1 0.8 0.027 15.1 0.8 2.0 2 1 0 2 2 1 0 Initiation control protein YabA LPP PF04728.13 EFW99645.1 - 0.027 14.8 0.5 0.08 13.3 0.5 1.8 1 0 0 1 1 1 0 Lipoprotein leucine-zipper ZapB PF06005.12 EFW99645.1 - 0.043 14.2 1.2 0.043 14.2 1.2 2.7 3 0 0 3 3 2 0 Cell division protein ZapB bZIP_1 PF00170.21 EFW99645.1 - 0.17 12.0 1.7 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 bZIP transcription factor NRBF2 PF08961.10 EFW99645.1 - 0.19 11.3 5.1 0.067 12.8 2.2 1.8 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DUF4618 PF15397.6 EFW99645.1 - 0.21 11.0 7.4 0.035 13.5 3.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Cep57_MT_bd PF06657.13 EFW99645.1 - 0.29 11.6 0.2 0.29 11.6 0.2 2.9 4 0 0 4 4 3 0 Centrosome microtubule-binding domain of Cep57 DUF3450 PF11932.8 EFW99645.1 - 0.3 10.4 4.3 0.46 9.7 3.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1640 PF07798.11 EFW99645.1 - 0.46 10.5 4.4 0.7 9.9 3.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) CtIP_N PF10482.9 EFW99645.1 - 0.87 9.6 6.3 0.13 12.3 2.1 1.8 2 0 0 2 2 1 0 Tumour-suppressor protein CtIP N-terminal domain DivIC PF04977.15 EFW99645.1 - 1.2 9.0 3.7 0.69 9.7 0.3 2.4 2 1 1 3 3 3 0 Septum formation initiator FUSC PF04632.12 EFW99645.1 - 3.2 6.2 5.4 5.1 5.5 5.4 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4685 PF15737.5 EFW99646.1 - 0.044 14.2 3.1 0.68 10.4 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4685) Sugar_tr PF00083.24 EFW99647.1 - 3e-25 89.0 28.3 1.3e-14 53.9 12.6 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2686 PF10887.8 EFW99647.1 - 0.063 12.2 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2686) Alpha_L_fucos PF01120.17 EFW99648.1 - 5.7e-85 285.8 7.3 8.3e-85 285.3 7.3 1.2 1 0 0 1 1 1 1 Alpha-L-fucosidase Auxin_canalis PF05703.11 EFW99649.1 - 4 7.3 21.5 0.24 11.3 10.9 3.2 3 1 0 3 3 3 0 Auxin canalisation UCH PF00443.29 EFW99650.1 - 3.9e-41 141.2 0.0 7.7e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFW99650.1 - 1.1e-18 67.9 0.4 1.9e-18 67.1 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EFW99650.1 - 0.021 14.3 3.3 0.32 10.4 0.7 2.7 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase SpoIIIAH PF12685.7 EFW99650.1 - 0.024 14.5 6.7 0.04 13.8 6.7 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein OrsD PF12013.8 EFW99650.1 - 0.16 12.4 1.6 0.56 10.7 0.0 2.6 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D DUF4778 PF16008.5 EFW99650.1 - 2.5 8.1 8.9 4.9 7.1 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Bud13 PF09736.9 EFW99650.1 - 4.7 7.6 15.3 3.8 7.9 13.3 1.9 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex VIT1 PF01988.19 EFW99650.1 - 8.5 6.2 9.3 17 5.2 9.3 1.4 1 0 0 1 1 1 0 VIT family Rhodanese PF00581.20 EFW99651.1 - 8.8e-12 45.5 0.0 1.7e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain polyprenyl_synt PF00348.17 EFW99652.1 - 2.8e-88 295.3 0.0 3.5e-88 295.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HSF_DNA-bind PF00447.17 EFW99653.1 - 3.9e-28 97.9 0.6 6.8e-28 97.1 0.6 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding DivIC PF04977.15 EFW99653.1 - 0.0072 16.1 3.0 1.4 8.7 0.0 2.6 2 0 0 2 2 2 2 Septum formation initiator FHIPEP PF00771.20 EFW99653.1 - 0.15 10.5 0.4 0.22 9.9 0.4 1.1 1 0 0 1 1 1 0 FHIPEP family Mod_r PF07200.13 EFW99653.1 - 0.31 11.1 3.0 10 6.2 0.0 2.5 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein APG6_N PF17675.1 EFW99653.1 - 2 9.0 7.1 14 6.2 2.0 3.3 3 1 0 3 3 3 0 Apg6 coiled-coil region APC_u15 PF16636.5 EFW99653.1 - 5.1 7.6 6.1 5.5 7.5 0.1 3.1 2 0 0 2 2 2 0 Unstructured region on APC between APC_crr regions 5 and 6 MFS_1 PF07690.16 EFW99654.1 - 2.8e-33 115.3 27.9 2.8e-33 115.3 27.9 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFW99654.1 - 0.001 18.5 8.7 0.001 18.5 8.7 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Stevor PF17410.2 EFW99654.1 - 0.24 10.9 0.1 0.36 10.3 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Brix PF04427.18 EFW99655.1 - 1.4e-31 110.1 0.0 2.3e-31 109.4 0.0 1.3 1 0 0 1 1 1 1 Brix domain BCS1_N PF08740.11 EFW99655.1 - 4.9e-29 101.7 0.0 2e-16 60.5 0.0 2.3 1 1 1 2 2 2 2 BCS1 N terminal AAA PF00004.29 EFW99655.1 - 1.4e-17 64.4 0.0 2.4e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFW99655.1 - 0.0026 18.1 0.1 0.013 15.9 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EFW99655.1 - 0.0035 16.9 0.0 0.008 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFW99655.1 - 0.0041 16.3 0.0 0.0075 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFW99655.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RuvB_N PF05496.12 EFW99655.1 - 0.022 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain APG6 PF04111.12 EFW99655.1 - 0.024 14.6 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Apg6 BARA domain AAA_5 PF07728.14 EFW99655.1 - 0.038 14.0 0.1 0.086 12.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFW99655.1 - 0.049 13.8 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFW99655.1 - 0.05 13.9 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFW99655.1 - 0.051 14.1 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EFW99655.1 - 0.08 13.4 0.7 1.1 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFW99655.1 - 0.083 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFW99655.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFW99655.1 - 0.14 12.7 0.0 0.32 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 EFW99655.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 EFW99655.1 - 0.16 11.9 0.1 0.64 9.9 0.0 2.1 3 0 0 3 3 2 0 NACHT domain TsaE PF02367.17 EFW99655.1 - 0.16 11.9 0.0 0.61 10.1 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 EFW99655.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_21 PF13304.6 EFW99655.1 - 0.21 11.4 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PHD PF00628.29 EFW99656.1 - 1.4e-09 37.7 5.1 2.6e-09 36.8 5.1 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFW99656.1 - 3.7e-05 23.2 2.0 6.8e-05 22.3 2.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 EFW99656.1 - 0.0024 17.5 0.6 0.0052 16.4 0.6 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 EFW99656.1 - 0.0051 16.7 2.8 0.0051 16.7 2.8 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-rbx1 PF12678.7 EFW99656.1 - 0.14 12.5 0.5 0.38 11.1 0.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFW99656.1 - 5.8 7.3 11.4 39 4.7 7.2 2.8 2 1 0 2 2 2 0 Ring finger domain UL42 PF17638.2 EFW99657.1 - 7.5 6.5 6.8 2.6 8.0 0.2 2.5 2 1 0 2 2 2 0 HCMV UL42 RPA43_OB PF17875.1 EFW99658.1 - 1.2e-34 119.7 4.2 1.3e-34 119.5 0.1 2.4 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EFW99658.1 - 1.5e-05 25.2 0.0 3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Ribosomal_S24e PF01282.19 EFW99659.1 - 4.3e-35 119.5 0.0 7.2e-35 118.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e Sugar_tr PF00083.24 EFW99660.1 - 6.6e-74 249.4 24.3 6.6e-74 249.4 24.3 3.4 2 1 0 2 2 2 1 Sugar (and other) transporter AA_permease_2 PF13520.6 EFW99660.1 - 5.3e-41 140.8 38.0 5.3e-41 140.8 38.0 3.9 3 2 0 3 3 3 2 Amino acid permease MFS_1 PF07690.16 EFW99660.1 - 1.7e-30 106.1 26.9 1.7e-30 106.1 26.9 4.5 3 2 1 4 4 4 3 Major Facilitator Superfamily AA_permease PF00324.21 EFW99660.1 - 2e-08 33.3 32.0 2e-08 33.3 32.0 2.8 2 1 0 2 2 2 1 Amino acid permease Ank_4 PF13637.6 EFW99661.1 - 1.3e-14 54.3 0.3 7e-06 26.5 0.0 3.4 1 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFW99661.1 - 2.2e-14 53.8 0.0 1.9e-05 25.2 0.2 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFW99661.1 - 5e-11 41.8 0.0 0.011 16.2 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFW99661.1 - 9.5e-11 41.7 0.0 0.0017 18.7 0.2 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFW99661.1 - 9.8e-10 38.5 0.1 0.0059 16.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Actin PF00022.19 EFW99663.1 - 1.8e-112 376.0 0.0 1.2e-111 373.2 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFW99663.1 - 0.0014 17.5 0.0 0.0054 15.6 0.0 1.8 1 1 0 1 1 1 1 MreB/Mbl protein GTP_cyclohydro2 PF00925.20 EFW99664.1 - 3.3e-60 202.4 0.0 3.9e-60 202.1 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF1325 PF07039.11 EFW99665.1 - 5.6e-37 126.8 0.1 1.1e-36 125.9 0.1 1.5 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 EFW99665.1 - 0.021 14.6 0.0 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain GidB PF02527.15 EFW99665.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Pro-kuma_activ PF09286.11 EFW99666.1 - 7.2e-36 123.6 0.0 1.1e-35 123.0 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFW99666.1 - 3e-06 26.7 0.0 6.1e-06 25.7 0.0 1.4 1 1 0 1 1 1 1 Subtilase family Arf PF00025.21 EFW99667.1 - 3.2e-74 248.2 0.3 3.7e-74 248.0 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFW99667.1 - 3.7e-14 53.0 0.0 5.1e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFW99667.1 - 4.3e-13 49.2 0.0 4.7e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFW99667.1 - 8e-13 48.3 2.1 6e-09 35.5 0.3 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFW99667.1 - 4.3e-11 42.6 0.1 5.4e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFW99667.1 - 5.9e-11 42.1 0.0 7.4e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFW99667.1 - 0.0005 20.1 0.1 0.0007 19.7 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Methyltrn_RNA_3 PF02598.17 EFW99667.1 - 0.049 13.1 0.0 0.058 12.9 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methyltransferase 6PF2K PF01591.18 EFW99667.1 - 0.05 12.9 0.3 0.087 12.1 0.1 1.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase DUF2457 PF10446.9 EFW99668.1 - 0.016 14.4 8.4 0.031 13.4 8.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pkinase PF00069.25 EFW99669.1 - 7.4e-63 212.4 0.0 1.1e-62 211.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99669.1 - 1.1e-30 106.8 0.0 5.8e-30 104.4 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFW99669.1 - 0.024 14.6 0.0 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFW99669.1 - 0.066 12.1 0.0 0.066 12.1 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 EFW99669.1 - 0.068 12.5 0.1 0.13 11.5 0.1 1.5 1 1 0 1 1 1 0 Kinase-like WHIM1 PF15612.6 EFW99669.1 - 0.14 11.7 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 PMI_typeI PF01238.21 EFW99671.1 - 1.4e-73 248.3 0.0 1.6e-73 248.1 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I DUF2894 PF11445.8 EFW99672.1 - 0.27 11.7 4.3 0.28 11.6 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2894) Histone PF00125.24 EFW99674.1 - 1.6e-51 174.1 2.5 1.8e-51 173.9 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFW99674.1 - 8.4e-06 26.1 0.0 1.3e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EFW99674.1 - 3.4e-05 24.5 1.0 3.9e-05 24.3 1.0 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EFW99674.1 - 3.6e-05 23.8 0.4 6.4e-05 23.0 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EFW99674.1 - 0.0035 17.6 0.3 0.0065 16.7 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFW99674.1 - 0.028 14.5 0.2 0.046 13.8 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFW99674.1 - 0.057 13.4 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated CENP-T_C PF15511.6 EFW99675.1 - 1.4e-08 34.8 0.1 1.8e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EFW99675.1 - 0.00012 22.2 0.1 0.00017 21.7 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EFW99675.1 - 0.00016 22.0 0.1 0.00019 21.8 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFW99675.1 - 0.0005 20.4 0.1 0.00065 20.0 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFW99675.1 - 0.00056 20.2 0.0 0.001 19.3 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFW99675.1 - 0.013 15.6 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFW99675.1 - 0.026 14.5 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EFW99675.1 - 0.17 11.6 0.1 0.21 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) MFS_1 PF07690.16 EFW99676.1 - 6e-41 140.5 58.2 9.2e-38 130.1 37.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_3 PF00202.21 EFW99677.1 - 2.1e-81 273.7 0.0 3e-81 273.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III FAD_binding_3 PF01494.19 EFW99677.1 - 3.6e-61 207.4 0.5 7.4e-60 203.0 0.5 2.3 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EFW99677.1 - 5.3e-16 59.1 0.0 1.3e-15 57.8 0.0 1.8 1 1 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.10 EFW99677.1 - 0.0018 17.3 0.0 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 Squalene epoxidase Cupin_2 PF07883.11 EFW99678.1 - 6.5e-09 35.4 0.0 1.1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain BBE PF08031.12 EFW99679.1 - 7e-10 38.9 0.0 8.2e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Berberine and berberine like Fungal_trans PF04082.18 EFW99680.1 - 3.9e-20 72.0 0.9 1.4e-19 70.1 0.7 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EFW99682.1 - 6.3e-81 271.7 0.7 1.6e-80 270.3 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 EFW99682.1 - 1.6e-70 237.8 0.2 3e-70 237.0 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme Acyl_transf_1 PF00698.21 EFW99682.1 - 3.9e-50 171.2 0.6 7e-50 170.3 0.6 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFW99682.1 - 3.9e-38 130.1 1.8 2.2e-37 127.7 0.4 2.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFW99682.1 - 1.4e-17 63.7 0.1 6e-08 32.9 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EFW99682.1 - 4.9e-15 55.9 0.0 1.1e-14 54.8 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension AMP-binding_C PF13193.6 EFW99682.1 - 5.8e-15 56.0 0.5 2.2e-14 54.1 0.1 2.3 2 0 0 2 2 1 1 AMP-binding enzyme C-terminal domain Thiolase_N PF00108.23 EFW99682.1 - 9.6e-08 31.7 3.7 4.9e-07 29.4 0.2 2.9 4 0 0 4 4 4 1 Thiolase, N-terminal domain SAT PF16073.5 EFW99682.1 - 0.0026 17.5 2.6 0.091 12.5 2.6 2.7 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ACP_syn_III PF08545.10 EFW99682.1 - 0.11 12.4 1.5 0.38 10.6 0.3 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Abhydrolase_5 PF12695.7 EFW99682.1 - 0.18 11.5 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DKCLD PF08068.12 EFW99683.1 - 3.8e-32 110.1 0.3 1.5e-30 105.1 0.3 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EFW99683.1 - 1.1e-23 83.2 0.7 2e-23 82.3 0.7 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EFW99683.1 - 1.7e-21 77.1 3.7 2e-19 70.4 0.2 3.5 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EFW99683.1 - 1.9e-21 75.8 0.7 3.9e-21 74.8 0.7 1.6 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EFW99683.1 - 0.0003 21.0 0.0 0.00077 19.7 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain RNA_polI_A34 PF08208.11 EFW99683.1 - 1.4 9.0 16.0 2.5 8.2 16.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Med19 PF10278.9 EFW99683.1 - 2.5 8.0 9.0 4.6 7.1 9.0 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CDP-OH_P_transf PF01066.21 EFW99684.1 - 5.5e-13 49.5 0.8 1e-12 48.6 0.1 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase eIF-3c_N PF05470.12 EFW99685.1 - 1.3e-174 581.9 18.2 1.3e-174 581.9 18.2 3.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EFW99685.1 - 3.2e-12 46.9 0.1 1.8e-11 44.5 0.0 2.4 2 0 0 2 2 2 1 PCI domain Nop14 PF04147.12 EFW99685.1 - 0.00069 18.0 20.3 0.00098 17.5 20.3 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 EFW99685.1 - 0.04 12.2 19.4 0.06 11.6 19.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PSII_Pbs27 PF13326.6 EFW99685.1 - 0.049 14.0 2.7 0.12 12.7 2.7 1.7 1 0 0 1 1 1 0 Photosystem II Pbs27 DUF2779 PF11074.8 EFW99685.1 - 0.21 12.0 2.4 2.7 8.5 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function(DUF2779) SDA1 PF05285.12 EFW99685.1 - 1.6 8.1 29.6 2.7 7.4 29.6 1.3 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 EFW99685.1 - 2.9 6.9 28.8 7.1 5.7 28.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) IFT57 PF10498.9 EFW99685.1 - 3.1 6.7 22.1 0.5 9.3 17.7 1.9 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 TRAPPC10 PF12584.8 EFW99686.1 - 1.1e-29 103.2 0.0 3.4e-29 101.6 0.0 1.9 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 BRO1 PF03097.18 EFW99688.1 - 0.00014 20.8 5.8 0.00025 20.0 5.8 1.4 1 1 0 1 1 1 1 BRO1-like domain eIF2A PF08662.11 EFW99689.1 - 2e-36 125.7 0.5 2.1e-34 119.1 0.1 3.4 3 2 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EFW99689.1 - 7.3e-05 22.5 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_H_2 PF13482.6 EFW99689.1 - 0.026 14.5 0.1 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 RNase_H superfamily DUF4467 PF14729.6 EFW99689.1 - 0.068 13.5 0.2 0.28 11.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) WD40 PF00400.32 EFW99689.1 - 0.34 11.8 2.1 6.8 7.7 0.0 3.8 5 0 0 5 5 5 0 WD domain, G-beta repeat Ribosomal_L30_N PF08079.12 EFW99690.1 - 3.6e-26 91.2 19.0 6.3e-26 90.4 19.0 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EFW99690.1 - 6.7e-16 57.9 2.3 6.7e-16 57.9 2.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DUF4520 PF15016.6 EFW99691.1 - 0.065 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) C2 PF00168.30 EFW99692.1 - 7.6e-14 51.9 0.1 1.6e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 C2 domain zf-MYND PF01753.18 EFW99693.1 - 5.5e-08 32.8 19.6 1.6e-07 31.3 19.6 1.9 1 0 0 1 1 1 1 MYND finger Ldl_recept_b PF00058.17 EFW99694.1 - 0.00037 20.9 2.9 1.3 9.6 0.3 5.5 5 1 0 5 5 5 1 Low-density lipoprotein receptor repeat class B SGL PF08450.12 EFW99694.1 - 0.089 12.4 0.1 2 7.9 0.0 2.6 2 1 2 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region DUF3445 PF11927.8 EFW99695.1 - 4.5e-60 203.1 0.0 9.2e-58 195.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3445) Mito_carr PF00153.27 EFW99696.1 - 6.3e-60 199.1 0.7 6.1e-20 71.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RhoGAP PF00620.27 EFW99697.1 - 1e-28 100.1 0.0 1.7e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Scytalone_dh PF02982.14 EFW99698.1 - 1.4e-87 291.5 1.1 1.6e-87 291.2 1.1 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EFW99698.1 - 1.3e-07 31.8 1.1 1.9e-07 31.3 1.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain LPD23 PF18838.1 EFW99698.1 - 0.011 15.4 0.2 0.026 14.3 0.2 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 Aminotran_4 PF01063.19 EFW99699.1 - 2.2e-13 50.6 0.0 3e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Plug_translocon PF10559.9 EFW99699.1 - 0.032 14.1 0.0 0.069 13.0 0.0 1.6 1 0 0 1 1 1 0 Plug domain of Sec61p HNH_2 PF13391.6 EFW99700.1 - 1.6e-08 34.5 0.0 3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Band_7 PF01145.25 EFW99701.1 - 4.8e-11 43.0 0.0 4.8e-11 43.0 0.0 3.3 3 2 0 3 3 3 1 SPFH domain / Band 7 family Leo1 PF04004.13 EFW99702.1 - 1e-33 116.5 0.0 1e-33 116.5 0.0 1.9 2 0 0 2 2 2 1 Leo1-like protein DUF3336 PF11815.8 EFW99702.1 - 7.3e-25 87.3 0.0 2.7e-24 85.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EFW99702.1 - 2.2e-09 37.8 0.6 2.2e-09 37.8 0.6 2.1 2 0 0 2 2 2 1 Patatin-like phospholipase Protamine_P2 PF00841.19 EFW99702.1 - 0.012 16.1 2.1 0.012 16.1 2.1 2.9 2 0 0 2 2 2 0 Sperm histone P2 CDC45 PF02724.14 EFW99702.1 - 8.9 4.5 22.6 0.054 11.8 13.8 1.7 2 0 0 2 2 2 0 CDC45-like protein HgmA PF04209.13 EFW99703.1 - 1.4e-192 640.1 0.0 1.6e-192 640.0 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Actin PF00022.19 EFW99704.1 - 7.4e-151 502.4 0.0 2.7e-150 500.5 0.0 1.7 1 1 0 1 1 1 1 Actin Proteasome PF00227.26 EFW99705.1 - 9.5e-44 149.2 0.3 1.1e-29 103.4 0.0 2.5 3 0 0 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.9 EFW99705.1 - 2e-12 46.5 0.1 1.5e-11 43.8 0.0 2.2 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature HSF_DNA-bind PF00447.17 EFW99706.1 - 3.5e-28 98.1 0.8 6.8e-28 97.1 0.8 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 EFW99706.1 - 3.2e-21 75.6 0.1 6.4e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Ets PF00178.22 EFW99706.1 - 0.18 12.3 0.0 0.9 10.0 0.0 2.1 2 0 0 2 2 2 0 Ets-domain FMO-like PF00743.19 EFW99707.1 - 4.9e-20 71.5 0.0 3.5e-06 25.7 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFW99707.1 - 6.2e-13 48.7 0.0 1.3e-07 31.2 0.0 3.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFW99707.1 - 2.5e-09 36.8 0.1 0.00018 20.8 0.0 3.1 3 0 0 3 3 3 3 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFW99707.1 - 1.1e-07 32.0 0.2 0.0078 16.2 0.0 3.4 3 0 0 3 3 3 3 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFW99707.1 - 2.6e-06 26.9 0.1 4.6e-05 22.8 0.1 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFW99707.1 - 8.3e-06 25.9 0.0 9e-05 22.6 0.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFW99707.1 - 0.0016 17.7 0.1 0.0035 16.6 0.0 1.5 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EFW99707.1 - 0.0051 16.4 0.9 0.24 11.0 0.1 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFW99707.1 - 0.049 14.2 0.1 4.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFW99707.1 - 0.071 11.8 0.1 0.46 9.1 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein UCH PF00443.29 EFW99708.1 - 8.2e-50 169.7 1.4 1e-49 169.4 1.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFW99708.1 - 8.3e-31 107.7 4.4 1.2e-30 107.2 4.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFW99708.1 - 3.3e-06 27.3 0.7 3.3e-06 27.3 0.7 2.6 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zinc_ribbon_9 PF14369.6 EFW99708.1 - 0.7 10.2 0.1 0.7 10.2 0.1 3.9 4 0 0 4 4 4 0 zinc-ribbon NmrA PF05368.13 EFW99709.1 - 1.9e-14 53.8 0.0 2.6e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFW99709.1 - 4.7e-14 52.4 0.1 8.7e-14 51.6 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFW99709.1 - 1.7e-12 47.6 0.0 2.5e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFW99709.1 - 3.1e-10 39.5 0.0 5.2e-10 38.8 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFW99709.1 - 2.9e-08 33.2 0.0 1.4e-07 30.9 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EFW99709.1 - 4.1e-06 26.4 0.0 1.5e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EFW99709.1 - 1.9e-05 24.2 0.0 3.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EFW99709.1 - 0.0099 15.1 0.2 2.1 7.5 0.2 2.8 1 1 1 2 2 2 1 Male sterility protein adh_short_C2 PF13561.6 EFW99709.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase ApbA PF02558.16 EFW99709.1 - 0.022 14.4 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA KR PF08659.10 EFW99709.1 - 0.022 14.7 0.0 4.7 7.1 0.0 2.6 3 0 0 3 3 3 0 KR domain SnoaL_3 PF13474.6 EFW99709.1 - 0.071 13.4 0.0 8.2 6.7 0.0 2.4 2 0 0 2 2 2 0 SnoaL-like domain Polysacc_synt_2 PF02719.15 EFW99709.1 - 0.092 11.9 0.0 0.17 11.0 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GST_N_3 PF13417.6 EFW99710.1 - 3.3e-16 59.5 0.1 6.7e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFW99710.1 - 9.1e-13 48.3 0.0 1.9e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFW99710.1 - 3.2e-11 43.4 0.0 5.6e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EFW99710.1 - 0.0014 18.8 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin ArgJ PF01960.18 EFW99713.1 - 3.2e-148 493.5 0.2 3.7e-148 493.3 0.2 1.0 1 0 0 1 1 1 1 ArgJ family E1-E2_ATPase PF00122.20 EFW99714.1 - 1.3e-44 151.8 0.1 1.3e-44 151.8 0.1 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFW99714.1 - 3.1e-43 147.6 0.6 6.3e-43 146.6 0.6 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFW99714.1 - 7.4e-19 68.9 3.3 1.9e-17 64.2 3.3 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFW99714.1 - 2.9e-16 58.9 0.1 6e-16 57.9 0.1 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFW99714.1 - 9.8e-13 48.0 0.0 2e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFW99714.1 - 7e-05 22.7 0.9 0.00014 21.7 0.9 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFW99714.1 - 0.054 13.9 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase B-block_TFIIIC PF04182.12 EFW99715.1 - 2.7e-13 49.8 0.0 5.8e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC WD40 PF00400.32 EFW99716.1 - 9.7e-59 194.0 33.0 6.1e-09 36.4 0.5 9.5 8 2 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99716.1 - 2e-23 82.5 3.1 0.0047 17.2 0.1 7.0 3 3 4 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFW99716.1 - 2.9e-07 29.8 0.1 0.46 9.4 0.0 5.1 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFW99716.1 - 8.8e-07 29.0 0.0 0.006 16.5 0.0 3.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EFW99716.1 - 3e-05 22.9 4.3 0.15 10.7 0.1 4.6 4 1 0 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 EFW99716.1 - 5.5e-05 23.0 0.5 0.81 9.7 0.0 4.7 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EFW99716.1 - 0.016 14.5 0.3 7.8 5.7 0.0 3.4 2 2 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 EFW99716.1 - 0.037 12.8 0.1 2.6 6.7 0.0 2.7 3 1 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region TFIIIC_delta PF12657.7 EFW99716.1 - 0.042 13.8 3.0 23 4.8 0.0 4.1 3 2 2 5 5 5 0 Transcription factor IIIC subunit delta N-term NLE PF08154.12 EFW99716.1 - 0.081 13.5 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 NLE (NUC135) domain WD40_like PF17005.5 EFW99716.1 - 0.14 11.4 0.0 3.8 6.8 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain IKI3 PF04762.12 EFW99716.1 - 0.26 9.3 0.5 2.1 6.2 0.1 2.2 2 1 0 2 2 2 0 IKI3 family Proteasome_A_N PF10584.9 EFW99716.1 - 0.49 10.1 2.8 34 4.2 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature CHB_HEX_C_1 PF13290.6 EFW99717.1 - 5.9e-08 32.6 11.9 9.5e-08 31.9 3.9 3.3 2 0 0 2 2 2 1 Chitobiase/beta-hexosaminidase C-terminal domain F5_F8_type_C PF00754.25 EFW99717.1 - 7.4e-08 32.6 1.0 7.6e-07 29.3 0.1 3.0 4 0 0 4 4 4 1 F5/8 type C domain Glyco_hydro_43 PF04616.14 EFW99717.1 - 1.3e-06 27.9 4.9 0.0091 15.3 2.2 2.5 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 Fn3_assoc PF13287.6 EFW99717.1 - 8.1e-06 25.9 10.9 1.6e-05 25.0 3.5 3.1 2 0 0 2 2 2 1 Fn3 associated Peptidase_C48 PF02902.19 EFW99718.1 - 1.7e-09 37.9 0.1 2.9e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Pro-kuma_activ PF09286.11 EFW99720.1 - 2.3e-37 128.5 0.1 8.5e-37 126.6 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Las1 PF04031.13 EFW99722.1 - 1.8e-59 200.2 3.2 3.4e-59 199.4 3.2 1.4 1 0 0 1 1 1 1 Las1-like CoA_transf_3 PF02515.17 EFW99724.1 - 3.4e-48 164.6 0.0 1.9e-45 155.6 0.0 2.3 2 0 0 2 2 2 2 CoA-transferase family III DUF4448 PF14610.6 EFW99726.1 - 0.0074 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Glyoxalase_4 PF13669.6 EFW99727.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.4 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Fe-S_biosyn PF01521.20 EFW99728.1 - 2.1e-11 44.0 0.0 0.00011 22.4 0.0 2.2 1 1 1 2 2 2 2 Iron-sulphur cluster biosynthesis Pap_E4 PF02711.14 EFW99728.1 - 1 10.4 5.7 2.3 9.2 0.8 2.5 1 1 1 2 2 2 0 E4 protein ubiquitin PF00240.23 EFW99729.1 - 1.3e-25 88.9 0.2 1.4e-25 88.8 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFW99729.1 - 7.5e-14 51.3 0.2 8.2e-14 51.2 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFW99729.1 - 8.9e-05 22.9 0.1 0.00026 21.4 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFW99729.1 - 0.005 16.7 0.0 0.0059 16.5 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain bZIP_1 PF00170.21 EFW99730.1 - 3.5e-08 33.4 14.8 1.1e-07 31.9 12.7 2.4 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 EFW99730.1 - 3.3e-06 27.5 12.3 3.3e-06 27.5 12.3 2.6 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_2 PF07716.15 EFW99730.1 - 5.4e-06 26.4 12.4 1.5e-05 24.9 9.7 2.8 2 0 0 2 2 2 1 Basic region leucine zipper CNTF PF01110.17 EFW99730.1 - 0.031 13.7 1.5 0.071 12.5 1.5 1.5 1 0 0 1 1 1 0 Ciliary neurotrophic factor KAsynt_C_assoc PF16197.5 EFW99730.1 - 0.68 10.4 2.8 12 6.4 0.0 2.7 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension FMO-like PF00743.19 EFW99731.1 - 1.3e-08 33.7 0.0 2.2e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFW99731.1 - 2.6e-06 27.6 0.0 7.2e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW99731.1 - 4.1e-06 26.2 0.0 0.0018 17.6 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFW99731.1 - 4.2e-06 26.2 0.0 0.00011 21.5 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFW99731.1 - 4.8e-05 23.4 0.3 0.013 15.5 0.0 3.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFW99731.1 - 0.0002 20.7 0.0 0.00085 18.7 0.0 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFW99731.1 - 0.0015 17.8 0.0 0.052 12.8 0.0 2.2 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EFW99731.1 - 0.12 11.0 0.1 0.2 10.3 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein adh_short PF00106.25 EFW99732.1 - 7.6e-26 90.8 0.0 2e-25 89.4 0.0 1.6 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW99732.1 - 4.2e-18 65.8 0.0 7.6e-18 64.9 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFW99732.1 - 0.009 15.9 0.1 2.9 7.8 0.0 2.3 2 0 0 2 2 2 2 KR domain PRA1 PF03208.19 EFW99733.1 - 5.1e-34 117.0 0.4 7.9e-34 116.3 0.4 1.2 1 0 0 1 1 1 1 PRA1 family protein SVM_signal PF12113.8 EFW99733.1 - 0.63 10.0 2.2 1.1 9.2 2.2 1.4 1 0 0 1 1 1 0 SVM protein signal sequence DUF3915 PF13054.6 EFW99733.1 - 8.5 6.4 11.3 0.4 10.7 2.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DHHC PF01529.20 EFW99734.1 - 3.1e-37 127.7 8.8 5.9e-37 126.8 8.8 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase zf-C2H2 PF00096.26 EFW99734.1 - 0.00023 21.4 31.6 0.067 13.7 0.1 6.3 6 0 0 6 6 6 4 Zinc finger, C2H2 type DctQ PF04290.12 EFW99734.1 - 0.009 15.9 0.3 0.009 15.9 0.3 2.5 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component zf-C2H2_jaz PF12171.8 EFW99734.1 - 0.013 15.8 2.4 0.95 9.8 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Yip1 PF04893.17 EFW99734.1 - 0.051 13.3 5.6 0.55 9.9 1.8 2.3 2 0 0 2 2 2 0 Yip1 domain zf-C2H2_4 PF13894.6 EFW99734.1 - 0.13 13.2 0.1 0.13 13.2 0.1 6.6 7 1 1 8 8 8 0 C2H2-type zinc finger FtsX PF02687.21 EFW99734.1 - 3.1 8.3 7.1 0.5 10.9 2.0 2.2 2 0 0 2 2 2 0 FtsX-like permease family DZR PF12773.7 EFW99734.1 - 7.2 6.7 16.7 15 5.7 8.0 3.6 3 0 0 3 3 3 0 Double zinc ribbon DUF3176 PF11374.8 EFW99736.1 - 2.2e-24 85.7 9.4 4.6e-24 84.7 9.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) AA_permease PF00324.21 EFW99737.1 - 2.5e-81 273.7 39.1 2.9e-81 273.5 39.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFW99737.1 - 1e-23 83.9 47.7 1.3e-23 83.6 47.7 1.1 1 0 0 1 1 1 1 Amino acid permease PSI_PSAK PF01241.18 EFW99737.1 - 0.076 13.0 0.9 0.32 11.0 0.6 2.2 2 0 0 2 2 2 0 Photosystem I psaG / psaK Ebp2 PF05890.12 EFW99738.1 - 1e-87 294.1 9.0 1e-87 294.1 9.0 2.4 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Bac_luciferase PF00296.20 EFW99739.1 - 5.2e-66 223.2 0.5 1e-65 222.3 0.5 1.4 1 1 0 1 1 1 1 Luciferase-like monooxygenase GPI-anchored PF10342.9 EFW99740.1 - 1.2e-08 35.6 0.2 1.2e-08 35.6 0.2 1.8 1 1 1 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Paramyxo_P_V_N PF13825.6 EFW99740.1 - 0.92 8.9 4.0 1.2 8.5 4.0 1.1 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus DUF1932 PF09130.11 EFW99741.1 - 2.2e-18 66.0 0.9 5e-18 64.8 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1932) F420_oxidored PF03807.17 EFW99741.1 - 1.4e-07 32.0 0.1 3.7e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFW99741.1 - 2e-05 24.8 0.0 4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFW99741.1 - 0.0059 16.0 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EFW99741.1 - 0.07 13.2 0.1 0.31 11.1 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PDH PF02153.17 EFW99741.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase Glyco_transf_90 PF05686.12 EFW99742.1 - 3.7e-13 49.1 1.8 1.3e-10 40.8 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferase family 90 MFS_1 PF07690.16 EFW99743.1 - 1.8e-17 63.4 27.7 1.1e-13 50.9 21.4 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily PDR_assoc PF08370.11 EFW99743.1 - 0.076 12.8 1.6 0.11 12.2 0.1 2.1 2 0 0 2 2 2 0 Plant PDR ABC transporter associated PITH PF06201.13 EFW99744.1 - 4.3e-36 124.4 0.0 5.7e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EFW99744.1 - 1.4e-22 79.6 0.0 2.5e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFW99744.1 - 1.2e-07 32.2 0.1 5.5e-07 30.0 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EFW99744.1 - 2e-05 24.1 0.0 4.3e-05 23.0 0.0 1.5 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFW99744.1 - 0.00014 22.1 0.0 0.042 14.2 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EFW99744.1 - 0.0039 17.1 0.0 0.0077 16.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family HyaE PF07449.11 EFW99744.1 - 0.0066 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EFW99744.1 - 0.019 15.1 0.1 0.044 14.0 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like DUF1207 PF06727.11 EFW99744.1 - 0.024 13.6 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1207) Serglycin PF04360.12 EFW99744.1 - 0.025 14.5 0.2 0.038 13.9 0.2 1.2 1 0 0 1 1 1 0 Serglycin Redoxin PF08534.10 EFW99744.1 - 0.27 10.9 1.2 3.4 7.4 0.1 2.4 2 1 1 3 3 3 0 Redoxin Pkinase PF00069.25 EFW99745.1 - 1e-64 218.5 0.0 1.2e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99745.1 - 1.5e-25 90.0 0.0 2e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFW99745.1 - 2.1e-06 27.3 0.0 1.1e-05 24.9 0.0 1.9 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 EFW99745.1 - 0.00073 19.5 0.4 0.0082 16.1 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF1229 PF06797.11 EFW99745.1 - 0.024 14.8 0.1 0.038 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) Kdo PF06293.14 EFW99745.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFW99745.1 - 0.12 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase P34-Arc PF04045.14 EFW99746.1 - 1.7e-104 348.8 0.1 2e-104 348.5 0.1 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Orn_Arg_deC_N PF02784.16 EFW99747.1 - 7.8e-86 287.5 0.0 1.1e-85 287.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFW99747.1 - 2.6e-18 66.0 0.0 3.5e-18 65.6 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EFW99747.1 - 0.0067 15.9 0.0 0.014 14.9 0.0 1.6 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Pex2_Pex12 PF04757.14 EFW99748.1 - 1.8e-39 135.7 0.0 2.2e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EFW99748.1 - 9.2e-12 44.6 8.6 1.4e-11 44.0 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFW99748.1 - 2e-10 40.8 9.6 3.2e-10 40.2 9.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFW99748.1 - 2.4e-10 40.1 6.3 3.5e-10 39.6 6.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFW99748.1 - 3e-10 39.8 6.4 4.5e-10 39.2 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFW99748.1 - 3.6e-08 33.3 7.3 7.1e-08 32.3 7.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFW99748.1 - 2.8e-07 30.3 7.5 4.3e-07 29.7 7.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFW99748.1 - 1e-06 28.8 8.5 1.8e-06 28.0 8.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFW99748.1 - 1.5e-06 28.1 5.5 2.3e-06 27.4 5.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFW99748.1 - 8.9e-06 25.9 8.8 1.8e-05 24.9 8.6 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EFW99748.1 - 0.00032 20.8 5.7 0.00053 20.1 5.7 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EFW99748.1 - 0.0014 18.4 2.4 0.0027 17.6 2.4 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein U-box PF04564.15 EFW99748.1 - 0.0073 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-RING_11 PF17123.5 EFW99748.1 - 0.062 13.1 2.8 0.13 12.0 2.8 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 EFW99748.1 - 0.4 10.5 7.2 0.69 9.8 7.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EFW99748.1 - 0.57 10.3 3.7 0.48 10.5 2.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Cerato-platanin PF07249.12 EFW99750.1 - 5.5e-05 23.3 1.7 8.3e-05 22.7 0.2 2.1 2 1 0 2 2 2 1 Cerato-platanin AF-4 PF05110.13 EFW99750.1 - 0.38 8.8 6.4 0.49 8.4 6.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ank_2 PF12796.7 EFW99751.1 - 2.4e-79 262.0 11.7 4.8e-15 55.9 0.0 6.6 2 1 7 9 9 9 7 Ankyrin repeats (3 copies) Ank PF00023.30 EFW99751.1 - 3.4e-43 144.3 5.4 0.0004 20.7 0.0 8.7 8 0 0 8 8 8 8 Ankyrin repeat Ank_3 PF13606.6 EFW99751.1 - 1.8e-42 138.4 1.4 0.00037 20.7 0.0 10.2 10 0 0 10 10 10 8 Ankyrin repeat Ank_4 PF13637.6 EFW99751.1 - 2.6e-39 133.1 3.6 2.7e-08 34.2 0.1 7.6 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFW99751.1 - 2.4e-23 81.9 9.4 4.1e-07 30.2 0.1 7.1 1 1 7 8 8 8 8 Ankyrin repeats (many copies) KAP_NTPase PF07693.14 EFW99751.1 - 3.7e-06 26.4 0.0 0.025 13.8 0.0 2.4 2 0 0 2 2 2 2 KAP family P-loop domain NACHT PF05729.12 EFW99751.1 - 5.6e-06 26.4 0.9 3.2e-05 23.9 0.1 2.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EFW99751.1 - 9.9e-05 22.6 0.7 0.0054 17.0 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EFW99751.1 - 0.00043 20.7 0.4 0.0043 17.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EFW99751.1 - 0.0086 16.0 0.3 0.15 12.0 0.0 2.3 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAT PF03417.16 EFW99751.1 - 0.014 15.1 2.5 1.2e+02 2.3 0.0 6.1 7 0 0 7 7 7 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase AAA PF00004.29 EFW99751.1 - 0.026 14.9 0.1 0.15 12.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFW99751.1 - 0.057 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase HTH_16 PF12645.7 EFW99751.1 - 0.13 12.4 0.0 1.4e+02 2.6 0.0 3.9 3 0 0 3 3 3 0 Helix-turn-helix domain ThiF PF00899.21 EFW99752.1 - 6.9e-57 192.6 0.0 1.1e-56 192.0 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EFW99752.1 - 4.6e-07 30.3 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.20 EFW99752.1 - 0.0071 16.4 0.1 0.046 13.8 0.0 2.2 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EFW99752.1 - 0.014 15.8 0.0 0.027 14.9 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EFW99752.1 - 0.035 13.4 1.4 0.14 11.4 0.6 2.0 2 0 0 2 2 2 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 EFW99752.1 - 0.46 10.7 1.6 1.8 8.8 1.6 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1343 PF07075.11 EFW99753.1 - 3.6e-114 381.8 0.0 4.1e-114 381.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1343) Fungal_trans PF04082.18 EFW99754.1 - 1.5e-09 37.3 0.0 2.2e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Urm1 PF09138.11 EFW99756.1 - 2.6e-33 114.3 0.0 2.9e-33 114.1 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EFW99756.1 - 1.8e-05 25.2 0.0 2.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 ThiS family N6-adenineMlase PF10237.9 EFW99757.1 - 1.7e-49 167.7 0.0 2.1e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase AAA_16 PF13191.6 EFW99757.1 - 0.067 13.6 0.7 0.35 11.2 0.4 2.0 2 0 0 2 2 2 0 AAA ATPase domain tRNA-synt_1 PF00133.22 EFW99758.1 - 1e-205 684.5 0.0 2.1e-204 680.2 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFW99758.1 - 1.6e-30 106.1 0.5 3.2e-30 105.1 0.5 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFW99758.1 - 4.2e-12 45.5 0.3 8.3e-06 24.8 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFW99758.1 - 1.1e-09 38.1 0.1 1.1e-06 28.3 0.0 2.7 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1b PF00579.25 EFW99758.1 - 0.067 12.5 0.0 0.21 10.9 0.0 1.8 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) tRNA-synt_1e PF01406.19 EFW99758.1 - 0.13 11.5 0.0 0.38 10.1 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain HET PF06985.11 EFW99759.1 - 6.5e-22 78.5 0.0 1.4e-21 77.4 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DnaJ PF00226.31 EFW99760.1 - 1.2e-18 66.9 2.1 2e-18 66.2 2.1 1.4 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 EFW99760.1 - 0.19 12.0 4.3 0.29 11.4 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Zn_clus PF00172.18 EFW99761.1 - 2.6 8.2 14.4 4.5 7.5 14.4 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Neurokinin_B PF03823.14 EFW99762.1 - 0.052 13.6 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Neurokinin B zf-C2H2_jaz PF12171.8 EFW99763.1 - 0.1 12.9 0.6 0.3 11.4 0.6 1.9 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-SCNM1 PF15803.5 EFW99763.1 - 0.18 11.4 4.8 0.37 10.5 4.8 1.5 1 0 0 1 1 1 0 Zinc-finger of sodium channel modifier 1 DEAD PF00270.29 EFW99764.1 - 2.1e-37 128.6 0.1 1.2e-36 126.1 0.1 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFW99764.1 - 2.9e-27 95.2 0.1 1.1e-26 93.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99764.1 - 0.00025 21.1 0.0 0.007 16.4 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFW99764.1 - 0.002 17.4 0.0 0.002 17.4 0.0 2.1 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DUF913 PF06025.12 EFW99764.1 - 1 8.3 4.1 5.7 5.8 2.6 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) AIM3 PF17096.5 EFW99764.1 - 2 9.4 5.2 5.1 8.1 5.2 1.6 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 RPN2_C PF18004.1 EFW99764.1 - 6.6 6.6 12.5 12 5.8 12.5 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CPSase_L_D2 PF02786.17 EFW99765.1 - 1.7e-81 272.8 0.4 2.6e-81 272.2 0.4 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EFW99765.1 - 5.2e-69 232.0 0.0 8.3e-69 231.3 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EFW99765.1 - 2.4e-38 131.0 0.0 4.9e-38 130.1 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFW99765.1 - 1.5e-31 108.7 0.0 3.9e-31 107.4 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EFW99765.1 - 9.8e-27 94.2 0.0 1.7e-26 93.3 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EFW99765.1 - 6.2e-19 67.6 2.7 9.8e-19 67.0 1.1 2.2 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EFW99765.1 - 2.3e-10 40.4 0.0 4.3e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 EFW99765.1 - 1.9e-09 37.2 0.9 7.1e-06 25.8 0.1 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 EFW99765.1 - 1.1e-08 34.8 0.1 2.1e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EFW99765.1 - 3.1e-05 24.1 0.0 7.2e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 EFW99765.1 - 0.00013 21.2 0.0 0.037 13.2 0.0 2.5 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_4 PF13535.6 EFW99765.1 - 0.00022 20.9 0.0 0.0031 17.1 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 EFW99765.1 - 0.00073 19.2 0.0 0.0046 16.6 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 EFW99765.1 - 0.01 15.1 0.0 0.058 12.6 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp GARS_A PF01071.19 EFW99765.1 - 0.014 15.2 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain HlyD_3 PF13437.6 EFW99765.1 - 0.036 14.8 0.1 9.1 7.0 0.0 3.0 2 0 0 2 2 2 0 HlyD family secretion protein ATPgrasp_YheCD PF14398.6 EFW99765.1 - 0.048 12.9 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 YheC/D like ATP-grasp Ank_2 PF12796.7 EFW99766.1 - 1.2e-11 45.0 0.0 1.3e-06 28.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFW99766.1 - 1.3e-07 31.7 0.0 0.82 10.2 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFW99766.1 - 0.0013 19.3 0.0 1.2 9.8 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW99766.1 - 0.0014 19.0 0.0 0.14 12.8 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFW99766.1 - 0.0019 18.5 0.0 4.2 7.8 0.0 3.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) DUF3883 PF13020.6 EFW99767.1 - 3.4e-05 23.8 0.0 7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) ZapB PF06005.12 EFW99767.1 - 0.0027 18.1 4.9 0.0071 16.8 4.9 1.7 1 0 0 1 1 1 1 Cell division protein ZapB Rootletin PF15035.6 EFW99767.1 - 0.015 15.3 0.1 0.032 14.3 0.1 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion APG6_N PF17675.1 EFW99767.1 - 0.17 12.4 5.5 0.43 11.1 5.5 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 EFW99767.1 - 0.19 10.6 5.0 0.37 9.6 5.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EFW99767.1 - 0.29 11.1 8.5 0.65 10.0 8.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Snapin_Pallidin PF14712.6 EFW99767.1 - 0.33 11.4 2.3 0.66 10.4 0.7 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DUF641 PF04859.12 EFW99767.1 - 0.33 11.3 3.4 1.3 9.4 3.4 2.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) NACHT PF05729.12 EFW99768.1 - 1.7e-16 60.6 0.1 3.6e-16 59.5 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Rcd1 PF04078.13 EFW99768.1 - 0.0043 16.4 0.7 0.0086 15.4 0.2 1.7 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like MA-Mit PF09245.10 EFW99768.1 - 0.035 13.6 0.0 0.76 9.2 0.0 2.3 2 1 0 2 2 2 0 Mycoplasma arthritidis-derived mitogen AAA_19 PF13245.6 EFW99768.1 - 0.055 13.8 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFW99768.1 - 0.056 13.7 0.1 0.28 11.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EFW99768.1 - 0.29 10.3 2.7 3.1 6.9 0.6 2.5 2 1 1 3 3 3 0 KAP family P-loop domain Pkinase PF00069.25 EFW99769.1 - 2.1e-43 148.6 0.0 8.8e-34 117.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ribonuc_2-5A PF06479.12 EFW99769.1 - 4.8e-40 136.7 0.0 8.2e-40 135.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 EFW99769.1 - 7.4e-23 81.2 0.0 6.1e-20 71.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFW99769.1 - 0.0015 17.4 2.0 0.0019 17.0 0.0 1.9 2 1 0 2 2 2 1 Fungal protein kinase PQQ_2 PF13360.6 EFW99769.1 - 0.0024 17.5 0.5 21 4.6 0.1 2.3 1 1 0 1 1 1 1 PQQ-like domain Kdo PF06293.14 EFW99769.1 - 0.0047 16.3 0.0 0.0094 15.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ PF01011.21 EFW99769.1 - 0.0062 16.4 0.1 5.7 7.1 0.0 2.8 2 0 0 2 2 2 2 PQQ enzyme repeat APH PF01636.23 EFW99769.1 - 0.0067 16.4 0.0 0.0067 16.4 0.0 2.6 3 0 0 3 3 3 1 Phosphotransferase enzyme family EXS PF03124.14 EFW99770.1 - 1.3e-109 366.5 0.0 1.5e-109 366.3 0.0 1.0 1 0 0 1 1 1 1 EXS family Cnd2 PF05786.14 EFW99772.1 - 1.8 7.1 4.8 2 7.0 4.8 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 PAS_9 PF13426.7 EFW99773.1 - 3.4e-24 85.1 0.0 3.5e-15 56.1 0.0 3.4 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 EFW99773.1 - 2.1e-18 66.4 0.0 4.9e-11 42.8 0.0 3.5 3 0 0 3 3 3 3 PAS fold GATA PF00320.27 EFW99773.1 - 2.7e-15 55.7 7.1 5.3e-15 54.7 7.1 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS PF00989.25 EFW99773.1 - 8.3e-14 51.6 0.0 5.6e-05 23.1 0.0 3.6 3 1 0 3 3 3 3 PAS fold PAS_4 PF08448.10 EFW99773.1 - 6.3e-10 39.3 0.0 0.0084 16.4 0.0 3.9 4 0 0 4 4 4 2 PAS fold PAS_11 PF14598.6 EFW99773.1 - 3.4e-07 30.4 0.0 0.011 15.8 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_2 PF08446.11 EFW99773.1 - 7e-06 26.7 0.0 0.0033 18.1 0.0 3.4 3 0 0 3 3 3 1 PAS fold Complex1_LYR PF05347.15 EFW99774.1 - 5e-18 64.9 4.3 6e-18 64.6 4.3 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFW99774.1 - 2.3e-07 31.5 0.3 3e-07 31.1 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EFW99774.1 - 0.33 11.6 2.6 0.9 10.2 0.5 2.0 1 1 1 2 2 2 0 Complex1_LYR-like MutS_V PF00488.21 EFW99775.1 - 0.0025 17.8 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 MutS domain V Ribosomal_L5_C PF00673.21 EFW99776.1 - 8.9e-28 96.3 0.0 1.4e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFW99776.1 - 3.8e-06 27.1 0.2 7.4e-06 26.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 DUF2205 PF10224.9 EFW99777.1 - 9.7e-35 118.4 1.2 1.8e-34 117.5 1.2 1.4 1 0 0 1 1 1 1 Short coiled-coil protein BPL_LplA_LipB PF03099.19 EFW99778.1 - 2.2e-06 27.6 0.0 4.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family polyprenyl_synt PF00348.17 EFW99779.1 - 3.8e-49 167.1 0.0 4.8e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase XFP_C PF09363.10 EFW99779.1 - 9.6e-09 35.0 0.0 1.7e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 XFP C-terminal domain WD40 PF00400.32 EFW99780.1 - 1.8e-49 164.6 23.6 7.7e-07 29.7 0.1 11.2 12 0 0 12 12 11 9 WD domain, G-beta repeat Utp12 PF04003.12 EFW99780.1 - 2e-19 69.9 0.2 3.6e-19 69.0 0.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EFW99780.1 - 2.5e-16 59.7 8.5 0.019 15.3 0.0 9.4 5 2 6 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFW99780.1 - 3.5e-08 32.8 0.9 1.1 8.2 0.0 5.6 4 2 1 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFW99780.1 - 8.8e-06 24.6 5.7 0.68 8.5 0.1 5.9 5 1 0 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EFW99780.1 - 0.00047 19.6 0.0 1.2 8.4 0.0 3.4 3 0 0 3 3 3 2 WD40-like domain eIF2A PF08662.11 EFW99780.1 - 0.026 14.4 0.0 1.1 9.1 0.0 3.5 3 1 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EFW99780.1 - 0.059 12.1 0.2 6.4 5.4 0.0 3.8 4 1 1 5 5 5 0 Nup133 N terminal like FGGY_C PF02782.16 EFW99780.1 - 0.066 12.9 0.4 0.72 9.6 0.1 2.4 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain CDtoxinA PF03498.14 EFW99780.1 - 0.068 12.8 0.0 5.5 6.6 0.0 2.5 2 0 0 2 2 2 0 Cytolethal distending toxin A/C domain BBS2_Mid PF14783.6 EFW99780.1 - 0.078 13.0 2.1 33 4.6 0.0 5.0 6 0 0 6 6 6 0 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 EFW99780.1 - 0.092 11.0 0.1 5 5.3 0.0 2.5 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Evr1_Alr PF04777.13 EFW99781.1 - 4.7e-24 84.7 0.1 6.5e-24 84.3 0.1 1.2 1 0 0 1 1 1 1 Erv1 / Alr family COG4 PF08318.12 EFW99782.1 - 5.8e-114 380.7 0.0 7.6e-114 380.3 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein TMF_TATA_bd PF12325.8 EFW99782.1 - 0.22 11.8 1.5 4 7.7 0.1 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding CorA PF01544.18 EFW99783.1 - 9.2e-24 84.3 4.7 1.3e-20 73.9 2.0 2.4 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Ricin_B_lectin PF00652.22 EFW99783.1 - 8.5e-14 51.9 0.0 2e-05 24.8 0.0 4.3 2 2 2 4 4 4 4 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EFW99783.1 - 0.0007 20.3 0.2 0.25 12.1 0.1 3.0 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like FIST_C PF10442.9 EFW99783.1 - 0.15 12.0 0.1 4.2 7.4 0.0 2.9 3 0 0 3 3 3 0 FIST C domain Pkinase PF00069.25 EFW99785.1 - 8.5e-69 231.9 0.0 2e-68 230.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99785.1 - 3.2e-50 170.8 0.0 1.5e-49 168.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFW99785.1 - 0.00018 20.4 0.4 0.00099 18.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFW99785.1 - 0.0017 17.8 0.0 0.064 12.6 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Lin-8 PF03353.15 EFW99785.1 - 3.5 7.1 9.7 6.7 6.2 6.8 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Rax2 PF12768.7 EFW99786.1 - 1.4e-62 211.0 7.4 2.3e-62 210.2 0.0 4.2 6 0 0 6 6 6 1 Cortical protein marker for cell polarity Kelch_1 PF01344.25 EFW99786.1 - 0.1 12.2 0.4 2.1 8.0 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Cys_Met_Meta_PP PF01053.20 EFW99788.1 - 2.7e-55 187.5 0.0 5.3e-55 186.5 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFW99788.1 - 0.089 11.9 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Cyclin PF08613.11 EFW99789.1 - 1.5e-09 38.4 0.0 2.5e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFW99789.1 - 0.0017 18.1 0.1 0.0029 17.3 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain AIG2_2 PF13772.6 EFW99790.1 - 7.6e-05 23.0 0.0 0.00046 20.5 0.0 2.0 2 0 0 2 2 2 1 AIG2-like family Ribosomal_S19e PF01090.19 EFW99791.1 - 6.6e-59 197.5 0.4 7.6e-59 197.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e NMO PF03060.15 EFW99792.1 - 8e-58 196.4 4.1 1.4e-57 195.6 4.1 1.3 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFW99792.1 - 4.2e-09 35.9 3.2 1.2e-08 34.4 1.2 2.3 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFW99792.1 - 0.07 12.1 11.0 0.012 14.7 7.3 1.5 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Sod_Fe_N PF00081.22 EFW99793.1 - 4.8e-16 59.0 3.0 6.8e-16 58.5 3.0 1.2 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.18 EFW99793.1 - 6.3e-10 39.1 0.1 1.7e-09 37.8 0.0 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain ApbA_C PF08546.11 EFW99794.1 - 4e-24 85.2 0.0 6e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFW99794.1 - 3.8e-13 49.3 0.0 1.1e-12 47.9 0.0 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA UQ_con PF00179.26 EFW99795.1 - 5.6e-18 64.9 0.0 8.3e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFW99795.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain Fungal_trans PF04082.18 EFW99796.1 - 7.3e-07 28.5 0.9 1.2e-06 27.7 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain MARVEL PF01284.23 EFW99797.1 - 0.013 15.6 1.7 0.025 14.6 0.5 1.9 2 0 0 2 2 2 0 Membrane-associating domain DUF973 PF06157.11 EFW99797.1 - 0.034 13.2 0.9 0.052 12.6 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) PgpA PF04608.13 EFW99797.1 - 0.12 12.5 1.9 0.18 11.9 0.8 1.8 2 0 0 2 2 2 0 Phosphatidylglycerophosphatase A HAGH_C PF16123.5 EFW99799.1 - 3e-19 69.3 0.0 4.6e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EFW99799.1 - 1.3e-14 54.7 1.6 1.5e-07 31.7 0.3 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFW99799.1 - 0.036 13.6 0.8 0.45 10.0 0.6 2.3 1 1 0 1 1 1 0 Beta-lactamase superfamily domain GFA PF04828.14 EFW99800.1 - 3.5e-09 36.9 0.0 4.2e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DUF2197 PF09963.9 EFW99800.1 - 0.013 15.7 0.0 0.018 15.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) Glyco_hydro_79C PF16862.5 EFW99801.1 - 7.2e-22 78.2 1.8 2.7e-21 76.4 1.8 2.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain UCR_6-4kD PF08997.10 EFW99801.1 - 0.00097 19.0 1.2 0.0023 17.8 0.1 2.3 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein LDB19 PF13002.7 EFW99802.1 - 3.6e-33 114.9 0.1 6.2e-33 114.1 0.1 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EFW99802.1 - 9e-07 29.1 0.0 1.9e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Pkinase PF00069.25 EFW99803.1 - 2.7e-12 46.6 0.0 7.6e-06 25.5 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99803.1 - 7.7e-05 22.1 0.0 0.28 10.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase zf-C2H2_jaz PF12171.8 EFW99804.1 - 1.3e-06 28.5 1.9 1.9e-06 28.0 0.5 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EFW99804.1 - 0.062 13.8 0.1 0.14 12.7 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2H2_2 PF12756.7 EFW99804.1 - 0.17 12.3 0.3 0.29 11.5 0.3 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EFW99804.1 - 0.98 9.9 3.5 17 6.0 1.1 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF2884 PF11101.8 EFW99805.1 - 0.0041 16.7 0.5 0.17 11.4 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2884) ArAE_2_N PF10337.9 EFW99806.1 - 4.1e-40 138.2 2.7 4.1e-40 138.2 2.7 3.7 2 2 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EFW99806.1 - 5.4e-19 68.6 14.7 5.4e-19 68.6 14.7 3.4 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EFW99806.1 - 3.3e-07 30.4 0.1 1.7e-06 28.1 0.1 2.3 1 1 0 1 1 1 1 Aromatic acid exporter family member 2 MadM PF03818.13 EFW99806.1 - 0.0035 17.2 0.6 0.028 14.3 0.4 2.6 2 0 0 2 2 2 1 Malonate/sodium symporter MadM subunit RF-1 PF00472.20 EFW99807.1 - 1.1e-23 83.3 3.1 1.4e-23 83.0 3.1 1.1 1 0 0 1 1 1 1 RF-1 domain PRIMA1 PF16101.5 EFW99807.1 - 0.061 13.4 2.1 0.12 12.5 2.1 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 M20_dimer PF07687.14 EFW99808.1 - 8.5e-20 70.7 0.0 1.8e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EFW99808.1 - 1e-17 64.5 2.5 1.2e-16 61.0 2.5 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EFW99808.1 - 0.082 12.6 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 Peptidase family M28 SWIB PF02201.18 EFW99809.1 - 2.5e-26 91.4 0.6 1.3e-25 89.0 0.3 2.2 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 EFW99809.1 - 2e-15 56.4 1.8 3.1e-15 55.8 1.0 1.8 2 0 0 2 2 2 1 DEK C terminal domain FliT PF05400.13 EFW99809.1 - 4.5 8.2 11.9 0.41 11.5 0.8 3.0 3 0 0 3 3 3 0 Flagellar protein FliT DTHCT PF08070.11 EFW99809.1 - 7.7 7.3 15.5 1 10.2 3.2 2.4 1 1 1 2 2 2 0 DTHCT (NUC029) region RabGAP-TBC PF00566.18 EFW99810.1 - 3.2e-24 85.8 0.0 6.7e-24 84.7 0.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EFW99810.1 - 1e-07 30.6 0.2 1e-07 30.6 0.2 1.6 2 0 0 2 2 2 1 SBE2, cell-wall formation ADH_N PF08240.12 EFW99811.1 - 5.6e-14 51.9 9.2 1.5e-13 50.5 9.2 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFW99811.1 - 9.4e-11 41.8 0.0 1.5e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EFW99811.1 - 0.0006 19.2 0.0 0.00096 18.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EFW99811.1 - 0.015 14.9 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 EFW99811.1 - 0.033 14.4 0.0 0.083 13.1 0.0 1.8 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EFW99811.1 - 0.037 13.3 0.0 0.06 12.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Aa_trans PF01490.18 EFW99812.1 - 6.4e-32 110.8 31.8 1.3e-31 109.7 31.8 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Methyltransf_11 PF08241.12 EFW99813.1 - 1.2e-17 64.3 0.1 2e-17 63.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW99813.1 - 8.7e-16 58.4 0.1 1.4e-15 57.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFW99813.1 - 1e-14 54.7 0.0 1.4e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99813.1 - 3.1e-14 53.0 0.0 4.5e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99813.1 - 5.2e-09 36.7 0.0 8.6e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFW99813.1 - 2.7e-07 30.2 0.0 3.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EFW99813.1 - 1.5e-06 27.9 0.0 2.8e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EFW99813.1 - 4.1e-06 26.7 0.0 7.6e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EFW99813.1 - 1.4e-05 24.2 0.0 2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 EFW99813.1 - 3.8e-05 23.1 0.0 5.4e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFW99813.1 - 0.00021 21.3 0.0 0.00033 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EFW99813.1 - 0.00032 20.2 0.0 0.00047 19.6 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_18 PF12847.7 EFW99813.1 - 0.0004 20.4 0.1 0.00064 19.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFW99813.1 - 0.0011 18.6 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.12 EFW99813.1 - 0.013 15.1 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TPMT PF05724.11 EFW99813.1 - 0.064 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_15 PF09445.10 EFW99813.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UPF0146 PF03686.13 EFW99813.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) PrmA PF06325.13 EFW99813.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Peptidase_M16_C PF05193.21 EFW99814.1 - 1.1e-16 61.4 0.0 1.2e-13 51.5 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFW99814.1 - 2.3e-05 24.4 0.0 9.8e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 EFW99814.1 - 0.23 10.6 3.9 0.5 9.5 3.5 1.7 2 0 0 2 2 2 0 Peptidase M16C associated RXT2_N PF08595.11 EFW99814.1 - 4.2 7.4 12.3 11 6.0 12.3 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal YlbD_coat PF14071.6 EFW99814.1 - 6.4 7.1 8.0 15 5.9 8.0 1.5 1 0 0 1 1 1 0 Putative coat protein Polysacc_deac_1 PF01522.21 EFW99815.1 - 7.1e-22 77.6 0.0 1e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 EFW99815.1 - 0.05 12.8 0.0 0.32 10.1 0.0 2.2 3 0 0 3 3 3 0 Divergent polysaccharide deacetylase Cnn_1N PF07989.11 EFW99816.1 - 3.9e-26 91.0 2.9 3.9e-26 91.0 2.9 16.2 7 4 4 14 14 13 2 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 EFW99816.1 - 5.5e-13 49.3 0.1 5.5e-13 49.3 0.1 7.4 9 1 0 9 9 9 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc7 PF08317.11 EFW99816.1 - 6.9e-08 31.7 191.3 0.017 14.0 24.1 9.6 2 2 6 9 9 9 8 Spc7 kinetochore protein KASH_CCD PF14662.6 EFW99816.1 - 3.5e-05 23.7 6.8 3.5e-05 23.7 6.8 9.7 3 1 7 10 10 9 4 Coiled-coil region of CCDC155 or KASH Rootletin PF15035.6 EFW99816.1 - 0.00029 20.9 12.9 0.00029 20.9 12.9 9.5 3 1 6 9 9 8 2 Ciliary rootlet component, centrosome cohesion HMMR_N PF15905.5 EFW99816.1 - 0.00062 19.3 167.9 0.13 11.7 33.7 10.0 3 3 7 10 10 10 6 Hyaluronan mediated motility receptor N-terminal DUF3138 PF11336.8 EFW99816.1 - 0.0011 17.7 8.0 0.0011 17.7 8.0 7.9 5 2 3 9 9 8 1 Protein of unknown function (DUF3138) MscS_porin PF12795.7 EFW99816.1 - 0.0033 17.0 26.2 0.0033 17.0 26.2 8.1 2 2 4 7 7 7 1 Mechanosensitive ion channel porin domain SHE3 PF17078.5 EFW99816.1 - 0.0051 16.6 1.0 0.0051 16.6 1.0 8.7 3 1 5 8 8 5 2 SWI5-dependent HO expression protein 3 ATG16 PF08614.11 EFW99816.1 - 0.0065 16.7 18.3 0.0065 16.7 18.3 11.7 2 1 8 12 12 10 3 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EFW99816.1 - 1.2 9.5 186.3 0.082 13.4 23.4 8.9 1 1 8 9 9 8 0 Fez1 AAA PF00004.29 EFW99817.1 - 1.8e-07 31.6 0.2 8.7e-07 29.4 0.2 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFW99817.1 - 0.0002 21.3 0.0 0.021 14.8 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 EFW99817.1 - 0.00086 19.9 0.0 0.0028 18.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFW99817.1 - 0.0012 19.3 0.6 0.0049 17.3 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFW99817.1 - 0.061 13.6 0.2 0.17 12.1 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFW99817.1 - 0.079 13.0 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) M16C_assoc PF08367.11 EFW99818.1 - 3.7e-73 245.7 0.0 5.5e-73 245.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFW99818.1 - 6.5e-25 88.2 0.0 1.1e-16 61.4 0.0 2.7 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFW99818.1 - 7.2e-09 35.8 0.0 1.9e-06 27.9 0.0 3.0 2 1 1 3 3 3 2 Insulinase (Peptidase family M16) Dicty_CAR PF05462.11 EFW99819.1 - 4.6e-11 42.4 8.9 4.6e-11 42.4 8.9 1.6 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EFW99819.1 - 5.9e-11 42.1 10.1 1e-10 41.3 10.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 EFW99819.1 - 5.2e-08 32.5 1.4 6.7e-08 32.2 1.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 EFW99819.1 - 1.5e-06 28.2 11.3 2.4e-06 27.5 11.3 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Frizzled PF01534.17 EFW99819.1 - 0.012 14.7 11.8 0.16 10.9 11.8 2.1 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region TMEM190 PF15431.6 EFW99819.1 - 0.021 15.0 1.1 0.04 14.1 0.3 1.8 2 0 0 2 2 2 0 Transmembrane protein 190 DNase_NucA_NucB PF14040.6 EFW99819.1 - 0.074 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB DUF3522 PF12036.8 EFW99819.1 - 9.2 6.5 12.2 25 5.1 9.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) Carb_bind PF10645.9 EFW99820.1 - 2.1e-18 66.3 2.2 8.5e-18 64.3 2.2 2.2 1 0 0 1 1 1 1 Carbohydrate binding Zn_clus PF00172.18 EFW99820.1 - 3.9e-09 36.5 11.4 1e-08 35.2 11.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRS1 PF04939.12 EFW99821.1 - 2.4e-55 186.8 2.0 2.8e-55 186.6 2.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Ribosomal_L5_C PF00673.21 EFW99822.1 - 9.1e-22 77.1 0.0 1.3e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFW99822.1 - 3.3e-20 72.2 0.0 7.1e-20 71.1 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L5 PCI PF01399.27 EFW99823.1 - 1e-08 35.6 0.0 2.1e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EFW99823.1 - 0.024 14.2 0.9 0.051 13.2 0.9 1.6 1 0 0 1 1 1 0 Rpn9 C-terminal helix Dam PF05869.11 EFW99823.1 - 0.03 13.9 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) NAD_binding_8 PF13450.6 EFW99824.1 - 1.6e-12 47.5 1.7 2.4e-11 43.7 0.0 3.3 3 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFW99824.1 - 2.6e-09 36.8 0.3 6.1e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFW99824.1 - 7.1e-07 28.7 0.2 2.3e-05 23.7 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 EFW99824.1 - 1.9e-06 26.6 0.1 1.8e-05 23.4 0.0 2.1 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFW99824.1 - 5.6e-06 25.8 0.1 0.00012 21.4 0.0 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFW99824.1 - 4.3e-05 23.6 0.4 0.017 15.1 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EFW99824.1 - 4.6e-05 23.2 2.2 9.6e-05 22.1 0.1 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Mqo PF06039.15 EFW99824.1 - 0.0013 17.4 0.0 0.0021 16.7 0.0 1.2 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) Thi4 PF01946.17 EFW99824.1 - 0.034 13.4 0.5 0.075 12.3 0.0 1.7 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.20 EFW99824.1 - 0.092 12.8 0.1 7.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EFW99824.1 - 0.24 11.7 1.5 5.1 7.4 0.1 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 EFW99825.1 - 1.4e-19 70.3 0.2 2.3e-19 69.6 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFW99825.1 - 6.1e-15 55.4 0.3 8.2e-15 55.0 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFW99825.1 - 0.00051 19.6 0.2 0.011 15.2 0.2 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ATP-synt_DE PF00401.20 EFW99825.1 - 0.16 12.3 0.6 24 5.3 0.0 2.4 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Sec8_exocyst PF04048.14 EFW99826.1 - 5.5e-46 156.0 0.3 1.1e-45 155.0 0.3 1.5 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EFW99826.1 - 1.3e-10 41.1 0.7 2.6e-10 40.1 0.7 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex MFS_1 PF07690.16 EFW99827.1 - 2e-36 125.7 35.7 2e-36 125.7 35.7 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFW99827.1 - 3.4e-14 52.5 5.3 3.6e-14 52.5 0.7 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EFW99827.1 - 4.1e-05 23.0 4.0 4.1e-05 23.0 4.0 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Arrestin_C PF02752.22 EFW99828.1 - 2e-13 50.9 0.0 1.5e-12 48.1 0.0 2.2 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFW99828.1 - 2.5e-08 34.1 0.0 4.3e-06 26.8 0.0 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain zf-H2C2_2 PF13465.6 EFW99829.1 - 2.5e-14 53.0 30.0 9.6e-09 35.3 1.6 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 EFW99829.1 - 4.2e-13 49.0 23.6 7.3e-05 23.0 0.8 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFW99829.1 - 0.00014 22.4 35.6 0.0018 18.9 0.5 5.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EFW99829.1 - 0.055 13.8 5.5 0.3 11.4 3.7 2.8 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-met PF12874.7 EFW99829.1 - 0.26 11.7 7.2 5.9 7.4 0.1 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EFW99829.1 - 0.71 10.0 3.7 10 6.2 0.4 2.4 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2HE PF16278.5 EFW99829.1 - 1.2 9.7 8.3 0.1 13.1 2.3 2.4 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger MDM10 PF12519.8 EFW99830.1 - 2.4e-163 544.3 0.0 2.8e-163 544.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 EFW99830.1 - 0.0014 18.1 0.2 2.1 7.8 0.1 2.6 3 0 0 3 3 3 2 Eukaryotic porin DUF4050 PF13259.6 EFW99830.1 - 0.042 14.2 0.2 0.17 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) T3SS_HrpK1 PF16937.5 EFW99831.1 - 0.045 13.4 1.8 0.062 12.9 1.8 1.1 1 0 0 1 1 1 0 Type III secretion system translocator protein, HrpF IMUP PF15761.5 EFW99831.1 - 3.1 8.5 7.4 59 4.4 5.0 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein Ammonium_transp PF00909.21 EFW99832.1 - 7.9e-111 370.6 21.5 9.4e-111 370.3 21.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Importin_rep_4 PF18808.1 EFW99833.1 - 3e-30 104.4 1.8 3e-30 104.4 1.8 4.7 6 0 0 6 6 5 1 Importin repeat HEAT_EZ PF13513.6 EFW99833.1 - 3.5e-19 68.9 14.8 1.3e-10 41.5 0.5 8.5 6 1 2 8 8 8 4 HEAT-like repeat HEAT PF02985.22 EFW99833.1 - 2.5e-18 64.6 10.3 0.0081 16.3 0.0 10.4 10 0 0 10 10 9 3 HEAT repeat Importin_rep_5 PF18816.1 EFW99833.1 - 8e-18 64.5 2.8 8.1e-18 64.5 0.2 2.5 3 0 0 3 3 2 1 Importin repeat HEAT_2 PF13646.6 EFW99833.1 - 3.7e-15 56.1 11.1 6.5e-05 23.2 0.0 7.6 3 2 4 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EFW99833.1 - 7.2e-12 45.7 0.0 0.0071 16.9 0.1 6.9 5 2 2 8 8 6 2 Vacuolar 14 Fab1-binding region Importin_rep_6 PF18829.1 EFW99833.1 - 7.3e-12 45.4 5.0 1e-11 44.9 0.3 3.5 4 0 0 4 4 2 1 Importin repeat 6 Cnd1 PF12717.7 EFW99833.1 - 2.9e-08 33.9 0.1 0.14 12.2 0.0 5.5 4 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.12 EFW99833.1 - 4.1e-08 32.0 3.7 0.0024 16.3 0.2 4.5 3 2 1 5 5 5 3 Down-regulated in metastasis RIX1 PF08167.12 EFW99833.1 - 6.7e-08 32.5 0.7 0.012 15.4 0.0 5.6 5 1 1 6 6 5 1 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 EFW99833.1 - 4.4e-07 29.7 0.2 0.0024 17.5 0.1 5.0 5 1 1 6 6 6 2 CLASP N terminal DUF3385 PF11865.8 EFW99833.1 - 2.4e-06 27.6 1.1 0.2 11.6 0.0 6.6 8 1 1 9 9 8 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 EFW99833.1 - 4.2e-06 26.1 0.3 4.2e-06 26.1 0.3 4.5 4 3 2 7 7 7 1 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 EFW99833.1 - 2.4e-05 23.1 2.5 0.0014 17.3 0.3 3.5 4 1 0 4 4 4 1 Adaptin N terminal region TFCD_C PF12612.8 EFW99833.1 - 0.00061 19.7 0.2 0.57 10.0 0.0 3.9 3 1 1 4 4 4 1 Tubulin folding cofactor D C terminal DUF3535 PF12054.8 EFW99833.1 - 0.001 18.4 1.6 0.01 15.1 0.2 2.8 3 1 0 3 3 3 1 Domain of unknown function (DUF3535) V-ATPase_H_N PF03224.14 EFW99833.1 - 0.0011 18.3 4.1 0.37 10.0 0.1 2.7 3 0 0 3 3 3 2 V-ATPase subunit H IBN_N PF03810.19 EFW99833.1 - 0.002 18.0 2.7 0.0034 17.3 0.1 2.9 3 1 1 4 4 3 1 Importin-beta N-terminal domain RTP1_C1 PF10363.9 EFW99833.1 - 0.0056 16.8 1.4 0.29 11.3 0.3 4.3 5 1 0 5 5 4 1 Required for nuclear transport of RNA pol II C-terminus 1 DNA_alkylation PF08713.11 EFW99833.1 - 0.0075 16.0 0.4 0.037 13.7 0.0 2.3 3 0 0 3 3 3 1 DNA alkylation repair enzyme Cnd3 PF12719.7 EFW99833.1 - 0.022 14.0 0.3 0.32 10.1 0.0 3.1 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Arm PF00514.23 EFW99833.1 - 0.045 13.8 8.8 2.2 8.5 0.0 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat MOR2-PAG1_C PF14225.6 EFW99833.1 - 0.061 13.2 0.6 5.8 6.7 0.2 3.0 2 0 0 2 2 2 0 Cell morphogenesis C-terminal Telomere_reg-2 PF10193.9 EFW99833.1 - 0.061 13.8 6.9 0.079 13.4 1.2 3.8 2 2 2 4 4 4 0 Telomere length regulation protein MFS_1 PF07690.16 EFW99834.1 - 2.8e-26 92.3 22.8 2.8e-26 92.3 22.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3237 PF11578.8 EFW99835.1 - 4.3e-34 117.5 0.0 4.8e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Peptidase_C48 PF02902.19 EFW99836.1 - 2.5e-14 53.6 0.0 2.2e-13 50.6 0.0 2.2 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SNase PF00565.17 EFW99837.1 - 8.8e-21 74.4 0.0 1.7e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Transglut_core PF01841.19 EFW99838.1 - 2.2e-12 47.4 0.3 6.2e-12 46.0 0.3 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.17 EFW99838.1 - 6.4e-06 25.8 0.0 2.1e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFW99838.1 - 1.1e-05 25.0 0.2 6.2e-05 22.5 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EFW99838.1 - 0.011 15.5 0.3 0.046 13.6 0.0 2.2 2 0 0 2 2 2 0 Variant SH3 domain Ank_2 PF12796.7 EFW99839.1 - 1.9e-33 114.9 0.0 4.2e-11 43.3 0.0 4.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFW99839.1 - 3.3e-32 110.4 0.3 5.7e-09 36.4 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFW99839.1 - 3.3e-25 87.4 0.0 0.00062 20.1 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 EFW99839.1 - 4.5e-25 85.0 0.0 0.00091 19.5 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EFW99839.1 - 9.2e-18 64.1 0.0 1.6e-05 25.1 0.0 5.1 2 2 3 5 5 5 4 Ankyrin repeats (many copies) NACHT_N PF17100.5 EFW99839.1 - 6.7e-16 58.8 0.5 6.7e-16 58.8 0.5 2.4 3 0 0 3 3 3 1 N-terminal domain of NWD NACHT-NTPase NACHT PF05729.12 EFW99839.1 - 5.9e-08 32.8 0.0 1.4e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFW99839.1 - 6.4e-08 33.2 0.2 2.4e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFW99839.1 - 0.0027 18.0 0.0 0.011 16.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EFW99839.1 - 0.016 14.4 0.8 0.13 11.5 0.8 2.5 1 1 0 1 1 1 0 KAP family P-loop domain RNA_helicase PF00910.22 EFW99839.1 - 0.11 12.8 0.0 0.86 10.0 0.0 2.4 2 1 0 2 2 2 0 RNA helicase STE PF02200.16 EFW99839.1 - 0.14 12.6 0.1 0.43 11.0 0.1 1.8 1 0 0 1 1 1 0 STE like transcription factor TBCA PF02970.16 EFW99840.1 - 1.1e-21 76.9 3.0 1.4e-21 76.6 3.0 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A Csm1_N PF18504.1 EFW99840.1 - 0.2 12.0 3.1 0.55 10.6 0.6 2.2 1 1 0 2 2 2 0 Csm1 N-terminal domain Pyr_redox_2 PF07992.14 EFW99841.1 - 2.8e-12 46.5 0.0 3.1e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFW99841.1 - 6.9e-09 35.9 4.3 4.5e-08 33.2 1.0 3.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding FMO-like PF00743.19 EFW99841.1 - 8.1e-09 34.4 0.0 1.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFW99841.1 - 1.5e-08 34.7 0.4 6.4e-08 32.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFW99841.1 - 8e-07 28.9 0.6 2.8e-06 27.2 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EFW99841.1 - 7e-06 25.6 0.0 0.0016 17.8 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EFW99841.1 - 0.00038 21.0 0.2 1.4 9.6 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFW99841.1 - 0.00082 18.7 0.1 3.5 6.8 0.0 3.8 3 1 1 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFW99841.1 - 0.002 17.4 0.0 0.0038 16.5 0.0 1.5 1 0 0 1 1 1 1 Thi4 family K_oxygenase PF13434.6 EFW99841.1 - 0.01 15.0 0.0 0.77 8.8 0.0 3.2 3 1 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EFW99841.1 - 0.018 14.3 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EFW99841.1 - 0.033 12.9 0.0 0.058 12.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Peptidase_C12 PF01088.21 EFW99842.1 - 1.6e-52 178.3 0.0 2.6e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EFW99842.1 - 0.05 13.5 0.0 0.17 11.8 0.0 1.9 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolases Aconitase PF00330.20 EFW99843.1 - 2e-149 498.5 0.0 2.5e-149 498.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFW99843.1 - 5.8e-41 139.9 0.0 1e-40 139.1 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Transglut_core2 PF13369.6 EFW99844.1 - 5.2e-17 61.8 0.0 1.6e-16 60.3 0.0 1.9 1 1 0 1 1 1 1 Transglutaminase-like superfamily YccV-like PF08755.11 EFW99844.1 - 1.7e-09 38.0 0.0 3.8e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like F-box-like PF12937.7 EFW99844.1 - 0.0013 18.6 0.4 0.0032 17.3 0.4 1.8 1 0 0 1 1 1 1 F-box-like THOC7 PF05615.13 EFW99845.1 - 1.1e-44 151.9 0.0 1.1e-44 151.9 0.0 2.0 1 1 1 2 2 2 1 Tho complex subunit 7 Sigma70_ner PF04546.13 EFW99845.1 - 0.0012 18.7 8.6 0.0068 16.3 0.1 3.1 3 0 0 3 3 3 2 Sigma-70, non-essential region ATG16 PF08614.11 EFW99845.1 - 0.019 15.2 6.9 2.3 8.4 5.1 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) LSM PF01423.22 EFW99846.1 - 6.9e-20 70.5 0.0 8.4e-20 70.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain RRM_1 PF00076.22 EFW99847.1 - 1.2e-30 105.1 0.0 7.1e-15 54.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EFW99847.1 - 0.02 14.5 0.7 6.8 6.5 0.1 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Limkain-b1 PF11608.8 EFW99847.1 - 0.028 14.5 0.0 1.7 8.8 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 SUIM_assoc PF16619.5 EFW99847.1 - 5.2 7.2 9.5 0.89 9.7 4.0 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 UPF0220 PF05255.11 EFW99848.1 - 3.1e-65 218.8 2.2 3.5e-65 218.6 2.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) F-box-like PF12937.7 EFW99849.1 - 0.0042 16.9 0.1 0.01 15.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like DUF3246 PF11596.8 EFW99849.1 - 0.0067 15.9 1.3 0.0067 15.9 1.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3246) CNDH2_C PF16858.5 EFW99849.1 - 0.26 11.1 13.2 0.66 9.8 13.2 1.6 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SUIM_assoc PF16619.5 EFW99849.1 - 0.78 9.9 26.0 3.8e+03 -2.0 26.0 3.8 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 p450 PF00067.22 EFW99851.1 - 2.9e-55 187.8 0.0 3.5e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Proteasome PF00227.26 EFW99852.1 - 9.1e-48 162.3 0.1 1e-47 162.1 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit LTV PF04180.14 EFW99854.1 - 6.1e-127 424.5 18.1 6.8e-127 424.3 18.1 1.0 1 0 0 1 1 1 1 Low temperature viability protein DNA_pol_phi PF04931.13 EFW99855.1 - 9.5e-147 490.3 14.9 9.5e-147 490.3 14.9 2.6 2 1 0 2 2 2 1 DNA polymerase phi Cnd3 PF12719.7 EFW99855.1 - 0.11 11.6 1.2 0.16 11.1 0.2 1.8 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 EFW99855.1 - 0.13 12.6 1.2 1.4 9.4 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat HEAT_EZ PF13513.6 EFW99855.1 - 0.9 10.1 8.0 9.2 6.9 0.0 5.1 4 0 0 4 4 4 0 HEAT-like repeat DUF4337 PF14235.6 EFW99855.1 - 1.8 8.7 13.2 0.55 10.3 0.7 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4337) Ank_2 PF12796.7 EFW99856.1 - 2.3e-43 146.7 8.2 1.2e-12 48.2 0.1 6.0 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFW99856.1 - 4.4e-41 138.8 14.9 1.6e-12 47.7 0.1 6.7 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW99856.1 - 3e-30 100.9 14.5 4.8e-05 23.4 0.0 9.7 9 0 0 9 9 9 6 Ankyrin repeat Ank PF00023.30 EFW99856.1 - 2.8e-23 81.3 19.9 0.00012 22.3 0.1 9.4 10 0 0 10 10 10 5 Ankyrin repeat Ank_5 PF13857.6 EFW99856.1 - 9.3e-18 64.1 24.8 6.1e-07 29.6 0.3 7.9 5 2 4 9 9 9 6 Ankyrin repeats (many copies) GTP_EFTU PF00009.27 EFW99856.1 - 4.7e-17 62.2 0.0 9.1e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFW99856.1 - 9.9e-08 32.3 0.5 2e-07 31.3 0.5 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 CorA PF01544.18 EFW99856.1 - 1.2e-06 28.1 1.6 3.3e-06 26.6 1.6 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein GTP_EFTU_D3 PF03143.17 EFW99856.1 - 0.0017 18.7 0.0 0.0036 17.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFW99856.1 - 0.087 12.9 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase Thioredoxin_7 PF13899.6 EFW99857.1 - 2.1e-15 56.7 0.1 1.5e-14 54.0 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin-like UBA_4 PF14555.6 EFW99857.1 - 2.9e-13 49.4 0.2 5.7e-13 48.5 0.2 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFW99857.1 - 1.5e-07 31.5 0.0 3.3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 UBX domain Serglycin PF04360.12 EFW99857.1 - 0.066 13.2 1.8 0.4 10.6 0.5 2.2 2 0 0 2 2 2 0 Serglycin Ribosomal_S11 PF00411.19 EFW99859.1 - 2e-46 156.9 1.2 2.4e-46 156.7 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EFW99859.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) BKACE PF05853.12 EFW99859.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme Pkinase PF00069.25 EFW99860.1 - 4.1e-66 223.0 0.0 5.7e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99860.1 - 7.9e-46 156.4 0.0 1.7e-45 155.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFW99860.1 - 2.9e-06 26.3 0.0 6.2e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFW99860.1 - 1.1e-05 24.9 0.0 0.0013 18.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like GlutR_dimer PF00745.20 EFW99860.1 - 0.085 13.3 0.1 0.23 11.9 0.1 1.7 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain Pkinase PF00069.25 EFW99861.1 - 3.1e-65 220.2 0.0 4.7e-65 219.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFW99861.1 - 5.7e-41 140.5 0.0 8.8e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ferric_reduct PF01794.19 EFW99861.1 - 2.5e-20 72.9 13.8 6.3e-20 71.6 13.0 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFW99861.1 - 1e-17 64.7 0.0 2e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFW99861.1 - 5.2e-09 36.2 0.0 1.2e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Kinase-like PF14531.6 EFW99861.1 - 5.7e-08 32.4 0.0 1.4e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFW99861.1 - 5e-05 22.4 0.5 5e-05 22.4 0.5 1.8 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFW99861.1 - 0.013 14.8 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFW99861.1 - 0.025 14.5 0.1 0.074 13.0 0.1 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFW99861.1 - 0.039 13.5 0.2 0.085 12.5 0.2 1.5 1 0 0 1 1 1 0 RIO1 family NAD_binding_1 PF00175.21 EFW99861.1 - 0.055 14.1 0.0 1.3 9.7 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain BLACT_WH PF17778.1 EFW99862.1 - 7.9e-16 57.8 0.9 1.5e-15 56.9 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 EFW99862.1 - 1.1e-14 54.9 5.0 1.8e-10 41.2 0.3 2.3 1 1 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFW99862.1 - 1e-06 28.4 0.7 2e-06 27.5 0.7 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFW99862.1 - 0.1 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DUF3430 PF11912.8 EFW99863.1 - 0.00065 19.8 4.5 0.00074 19.6 4.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) TauD PF02668.16 EFW99864.1 - 3.7e-61 207.3 1.4 4.7e-61 206.9 1.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NOA36 PF06524.12 EFW99865.1 - 5.9 6.1 6.0 8.6 5.6 6.0 1.2 1 0 0 1 1 1 0 NOA36 protein Whi5 PF08528.11 EFW99866.1 - 1.7e-10 40.2 0.3 2.9e-10 39.5 0.3 1.4 1 0 0 1 1 1 1 Whi5 like MutS_V PF00488.21 EFW99868.1 - 1.2e-68 230.8 0.4 1.3e-67 227.5 0.4 2.3 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFW99868.1 - 5.7e-33 114.8 0.7 1.2e-32 113.7 0.7 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EFW99868.1 - 7.2e-28 97.1 0.1 2.1e-27 95.6 0.0 1.9 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EFW99868.1 - 1.9e-09 37.9 0.1 2.2e-08 34.5 0.0 2.6 3 0 0 3 3 3 1 MutS domain II CSTF2_hinge PF14327.6 EFW99869.1 - 4.9e-30 103.8 0.6 9.5e-30 102.9 0.6 1.5 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EFW99869.1 - 6.7e-21 73.9 0.0 1.1e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) R3H PF01424.22 EFW99869.1 - 5.6e-14 51.9 0.0 1.1e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 R3H domain CSTF_C PF14304.6 EFW99869.1 - 5.5e-10 38.7 1.2 1.6e-09 37.2 1.2 1.8 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal zf-NF-X1 PF01422.17 EFW99869.1 - 0.0066 16.5 29.5 0.0075 16.3 9.0 13.8 13 1 0 13 13 13 6 NF-X1 type zinc finger DUF2201_N PF13203.6 EFW99869.1 - 0.0085 15.7 1.2 0.14 11.7 1.3 2.3 1 1 0 1 1 1 1 Putative metallopeptidase domain DDHD PF02862.17 EFW99869.1 - 0.073 13.2 2.1 0.18 11.9 2.1 1.6 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 EFW99869.1 - 1.5 8.6 30.0 2.9 7.6 30.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 EFW99869.1 - 3.1 6.7 38.3 7.1 5.5 38.3 1.5 1 0 0 1 1 1 0 Paf1 BUD22 PF09073.10 EFW99869.1 - 6.9 5.9 37.9 13 5.0 37.9 1.3 1 0 0 1 1 1 0 BUD22 AMP-binding PF00501.28 EFW99870.1 - 6.1e-39 133.8 0.0 3.6e-28 98.3 0.0 2.0 1 1 1 2 2 2 2 AMP-binding enzyme Myb_DNA-bind_6 PF13921.6 EFW99871.1 - 4.8e-09 36.3 0.1 7.1e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFW99871.1 - 6.2e-05 23.1 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rad21_Rec8_N PF04825.13 EFW99873.1 - 5.9e-39 132.6 0.0 1.1e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EFW99873.1 - 2.8e-08 32.9 0.4 8.9e-08 31.3 0.1 2.0 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein Pam17 PF08566.10 EFW99874.1 - 8.3e-59 198.1 0.0 1.2e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Glyco_hydro_76 PF03663.14 EFW99876.1 - 1.7e-150 501.6 31.5 2e-150 501.4 31.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFW99876.1 - 0.0083 15.2 2.1 0.0083 15.2 2.1 3.1 2 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 DUF2828 PF11443.8 EFW99877.1 - 9.4e-87 291.6 2.7 1.6e-56 191.7 0.6 5.2 3 2 1 4 4 4 2 Domain of unknown function (DUF2828) Taxilin PF09728.9 EFW99877.1 - 1e-67 228.5 63.8 1e-67 228.5 63.8 2.7 2 1 0 2 2 2 1 Myosin-like coiled-coil protein DUF4156 PF13698.6 EFW99877.1 - 0.061 13.7 2.2 5 7.5 0.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4156) Alg6_Alg8 PF03155.15 EFW99878.1 - 1.4e-123 413.4 25.3 2.4e-80 270.8 8.4 2.6 3 0 0 3 3 3 2 ALG6, ALG8 glycosyltransferase family SURF4 PF02077.15 EFW99878.1 - 1.1e-91 307.2 5.6 1.1e-91 307.2 5.6 2.0 2 0 0 2 2 2 1 SURF4 family HAD_2 PF13419.6 EFW99879.1 - 2.4e-15 57.1 0.0 6.3e-15 55.7 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFW99879.1 - 2e-06 28.3 0.0 0.00013 22.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFW99879.1 - 0.0007 19.6 0.1 0.0013 18.8 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like STAT2_C PF12188.8 EFW99879.1 - 0.026 14.4 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Signal transducer and activator of transcription 2 C terminal FemAB PF02388.16 EFW99879.1 - 0.028 13.3 0.0 0.33 9.8 0.0 2.0 2 0 0 2 2 2 0 FemAB family Gag_p10 PF02337.17 EFW99879.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral GAG p10 protein Glyco_transf_20 PF00982.21 EFW99880.1 - 2.5e-164 547.5 0.0 3.4e-164 547.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFW99880.1 - 2.1e-42 144.9 0.0 3.3e-42 144.2 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EFW99880.1 - 0.0032 17.2 0.5 0.0059 16.3 0.5 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Pkinase_Tyr PF07714.17 EFW99881.1 - 0.0068 15.7 0.8 0.038 13.3 0.8 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFW99881.1 - 0.0075 15.7 0.0 0.016 14.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.16 EFW99882.1 - 1.2e-23 83.6 25.0 6.5e-23 81.2 24.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily SPT_ssu-like PF11779.8 EFW99883.1 - 3.7e-19 68.1 5.5 6.3e-19 67.3 5.5 1.4 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like COX7a PF02238.15 EFW99883.1 - 0.056 13.9 1.4 0.09 13.2 1.4 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII KIF1B PF12423.8 EFW99884.1 - 0.29 11.6 1.5 0.36 11.3 0.1 1.9 2 0 0 2 2 2 0 Kinesin protein 1B NmrA PF05368.13 EFW99885.1 - 3.9e-15 56.1 0.0 4.4e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFW99885.1 - 8.8e-11 42.0 0.0 1.1e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EFW99885.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 KR domain BOP1NT PF08145.12 EFW99886.1 - 1.1e-101 340.2 0.3 1.5e-101 339.8 0.3 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EFW99886.1 - 3.6e-21 75.1 6.0 7.6e-11 42.4 1.0 6.2 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99886.1 - 1.3e-06 28.6 0.2 0.98 9.8 0.0 5.3 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DMRT-like PF15791.5 EFW99886.1 - 0.18 12.2 0.2 13 6.3 0.1 2.6 2 0 0 2 2 2 0 Doublesex-and mab-3-related transcription factor C1 and C2 MMR_HSR1 PF01926.23 EFW99887.1 - 6e-17 61.8 0.1 3.6e-15 56.0 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFW99887.1 - 3.9e-07 29.7 0.2 4.9e-06 26.1 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFW99887.1 - 6.7e-06 26.1 0.2 0.0026 17.7 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EFW99887.1 - 0.0016 18.6 0.2 0.085 12.9 0.1 2.6 2 0 0 2 2 2 1 Dynamin family AIG1 PF04548.16 EFW99887.1 - 0.0062 15.9 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 AIG1 family cobW PF02492.19 EFW99887.1 - 0.11 12.0 0.3 0.37 10.4 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF2956 PF11169.8 EFW99888.1 - 0.098 12.9 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Ecm29 PF13001.7 EFW99889.1 - 1.5e-150 502.2 0.0 5.3e-149 497.1 0.0 3.0 2 1 1 3 3 3 1 Proteasome stabiliser HEAT PF02985.22 EFW99889.1 - 0.00037 20.5 10.0 0.96 9.9 0.1 8.8 10 0 0 10 10 10 1 HEAT repeat IFRD PF05004.13 EFW99889.1 - 0.13 11.3 2.8 0.37 9.9 0.1 3.0 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 EFW99889.1 - 0.45 11.1 13.2 44 4.7 0.0 7.2 7 1 0 7 7 7 0 HEAT-like repeat FA_desaturase PF00487.24 EFW99890.1 - 5.3e-23 82.2 19.1 1.1e-22 81.2 19.1 1.5 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EFW99890.1 - 1.6e-07 31.6 0.0 3.8e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Prenyltrans PF00432.21 EFW99891.1 - 7.4e-42 140.8 9.1 5.1e-12 45.3 0.1 6.2 6 2 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EFW99891.1 - 0.087 11.8 0.0 2.3 7.1 0.1 3.2 3 1 0 3 3 3 0 A-macroglobulin TED domain NmrA PF05368.13 EFW99892.1 - 2.1e-18 66.7 0.0 2.6e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFW99892.1 - 6.8e-07 29.3 0.1 2e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EFW99892.1 - 0.052 13.4 0.1 0.091 12.7 0.1 1.3 1 0 0 1 1 1 0 KR domain FAA_hydrolase PF01557.18 EFW99893.1 - 2.4e-62 210.5 0.0 2.9e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family GspH PF12019.8 EFW99893.1 - 0.026 14.9 0.2 0.051 14.0 0.2 1.5 1 0 0 1 1 1 0 Type II transport protein GspH SLX9 PF15341.6 EFW99895.1 - 1.2e-34 119.5 1.9 1.6e-34 119.1 1.9 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 FUSC PF04632.12 EFW99895.1 - 2.5 6.5 10.6 3.1 6.2 10.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4246 PF14033.6 EFW99896.1 - 1.5e-69 235.3 0.0 2.3e-40 139.1 0.0 3.4 2 1 0 3 3 3 3 Protein of unknown function (DUF4246) Lectin_C_term PF18022.1 EFW99896.1 - 0.051 14.0 1.0 0.48 10.9 0.0 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin C-terminal domain Peptidase_C14 PF00656.22 EFW99901.1 - 4.1e-63 213.6 0.0 5.6e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain KAR PF15222.6 EFW99901.1 - 0.1 12.9 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 Kidney androgen-regulated Raptor_N PF14538.6 EFW99901.1 - 0.11 12.4 0.4 0.36 10.8 0.0 2.0 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain Clathrin_bdg PF15045.6 EFW99902.1 - 0.05 13.6 0.3 4.3 7.4 0.2 2.7 1 1 1 2 2 2 0 Clathrin-binding box of Aftiphilin, vesicle trafficking DUF4328 PF14219.6 EFW99902.1 - 0.053 13.1 0.4 0.12 12.0 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) CcmD PF04995.14 EFW99902.1 - 0.5 10.5 4.5 1 9.5 4.5 1.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) SKG6 PF08693.10 EFW99902.1 - 2.1 7.8 5.9 0.2 11.1 0.3 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain MPC PF03650.13 EFW99904.1 - 1.7e-34 118.3 0.1 2.1e-34 118.0 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers End_beta_barrel PF12195.8 EFW99904.1 - 0.015 15.2 0.1 1.6 8.7 0.0 2.5 1 1 1 2 2 2 0 Beta barrel domain of bacteriophage endosialidase MtN3_slv PF03083.16 EFW99904.1 - 0.034 14.2 0.6 0.054 13.5 0.6 1.4 1 1 0 1 1 1 0 Sugar efflux transporter for intercellular exchange KCH PF16944.5 EFW99904.1 - 0.043 13.6 0.1 0.047 13.5 0.1 1.1 1 0 0 1 1 1 0 Fungal potassium channel DAP3 PF10236.9 EFW99906.1 - 3.9e-84 282.5 0.0 4.8e-84 282.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 S-methyl_trans PF02574.16 EFW99907.1 - 1.3e-59 202.2 0.0 1.5e-59 202.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Ank_2 PF12796.7 EFW99908.1 - 9.5e-71 234.4 7.8 9.2e-17 61.4 0.3 6.4 2 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFW99908.1 - 3.4e-67 222.0 12.5 7e-11 42.4 0.2 8.1 2 1 7 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 EFW99908.1 - 8.4e-64 209.4 12.2 2.2e-07 31.0 0.0 11.4 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.6 EFW99908.1 - 5e-61 195.4 3.0 3.8e-05 23.8 0.0 11.5 11 0 0 11 11 11 10 Ankyrin repeat Ank_5 PF13857.6 EFW99908.1 - 7.5e-55 182.3 10.6 7e-09 35.8 0.0 10.8 1 1 10 11 11 11 11 Ankyrin repeats (many copies) Peptidase_S8 PF00082.22 EFW99908.1 - 3.6e-10 39.6 2.6 5e-09 35.8 2.6 2.7 1 1 0 1 1 1 1 Subtilase family Prenyltrans PF00432.21 EFW99909.1 - 1.1e-58 194.6 10.1 1.4e-13 50.3 0.1 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EFW99909.1 - 8.1e-05 21.9 0.0 0.062 12.4 0.0 3.1 2 1 2 4 4 4 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EFW99909.1 - 0.0065 15.6 0.5 0.25 10.4 0.0 2.9 1 1 2 3 3 3 1 Squalene-hopene cyclase C-terminal domain PhyH PF05721.13 EFW99910.1 - 6.6e-09 36.3 1.3 2.4e-07 31.2 1.3 2.2 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Ycf9 PF01737.17 EFW99910.1 - 0.13 12.2 0.2 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 YCF9 MFS_1 PF07690.16 EFW99912.1 - 3.9e-31 108.3 40.6 8.5e-30 103.9 31.6 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EFW99912.1 - 4e-08 32.1 5.5 4e-08 32.1 5.5 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EFW99912.1 - 2.2 6.5 11.3 2 6.6 1.0 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Nop14 PF04147.12 EFW99913.1 - 1.5e-241 804.3 33.3 3.3e-128 429.3 0.0 2.1 1 1 1 2 2 2 2 Nop14-like family Chromo PF00385.24 EFW99914.1 - 1.3e-06 28.2 0.0 2.8e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Zn_clus PF00172.18 EFW99915.1 - 1.3e-06 28.4 9.1 2.7e-06 27.4 9.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNF2_N PF00176.23 EFW99916.1 - 6.5e-58 196.1 0.0 1.1e-57 195.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EFW99916.1 - 3.8e-55 186.9 0.2 9.4e-55 185.6 0.2 1.7 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 EFW99916.1 - 4e-15 56.1 0.0 9.6e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99916.1 - 2.9e-08 33.9 0.0 4.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFW99916.1 - 0.015 14.5 0.0 0.051 12.7 0.0 1.8 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EFW99916.1 - 0.13 11.9 0.0 0.42 10.3 0.0 1.9 2 1 0 2 2 2 0 SWI2/SNF2 ATPase Ank_2 PF12796.7 EFW99917.1 - 2.7e-169 550.2 0.0 1.2e-18 67.5 0.0 9.9 1 1 12 13 13 13 13 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFW99917.1 - 1.6e-97 318.3 0.0 2.6e-09 37.2 0.0 17.5 3 2 14 17 17 17 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFW99917.1 - 3.5e-91 288.1 0.0 0.001 19.4 0.0 18.7 18 0 0 18 18 18 18 Ankyrin repeat Ank PF00023.30 EFW99917.1 - 3.4e-84 273.9 0.0 0.003 17.9 0.0 19.7 20 0 0 20 20 19 17 Ankyrin repeat Ank_4 PF13637.6 EFW99917.1 - 4.6e-76 250.3 0.0 7.2e-08 32.8 0.0 13.4 3 2 10 15 15 15 14 Ankyrin repeats (many copies) NACHT PF05729.12 EFW99917.1 - 1.8e-06 28.0 0.7 1.8e-05 24.7 0.0 2.7 2 1 0 2 2 2 1 NACHT domain DUF2384 PF09722.10 EFW99917.1 - 0.00015 21.8 0.5 3.8e+02 1.2 0.0 8.5 9 0 0 9 9 9 0 Protein of unknown function (DUF2384) DUF676 PF05057.14 EFW99917.1 - 0.00017 21.1 0.0 0.00031 20.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) AAA_16 PF13191.6 EFW99917.1 - 0.00027 21.4 0.0 0.0011 19.4 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain PGAP1 PF07819.13 EFW99917.1 - 0.0039 17.0 0.0 0.0073 16.1 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein AAA_22 PF13401.6 EFW99917.1 - 0.014 15.6 0.0 0.046 14.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFW99917.1 - 0.015 15.0 0.2 0.041 13.6 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Abhydrolase_6 PF12697.7 EFW99917.1 - 0.044 14.4 0.1 0.15 12.6 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Amino_oxidase PF01593.24 EFW99918.1 - 2.2e-15 56.9 2.1 4.9e-14 52.5 2.1 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFW99918.1 - 1.9e-09 37.6 0.3 9e-09 35.4 0.3 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFW99918.1 - 2.5e-06 27.3 1.3 0.0002 21.1 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFW99918.1 - 0.0031 18.0 0.0 0.12 13.0 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFW99918.1 - 0.0037 16.5 0.5 0.029 13.6 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFW99918.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Mt_ATP-synt_B PF05405.14 EFW99919.1 - 3e-48 163.5 9.1 3.7e-48 163.2 9.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Dak2 PF02734.17 EFW99919.1 - 0.18 11.7 3.2 0.27 11.1 2.4 1.7 1 1 0 1 1 1 0 DAK2 domain adh_short_C2 PF13561.6 EFW99920.1 - 9.7e-52 175.8 0.1 1.2e-51 175.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFW99920.1 - 1.2e-47 161.9 1.4 1.6e-47 161.5 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase MutS_V PF00488.21 EFW99922.1 - 1.1e-45 156.0 2.2 8.1e-28 97.7 0.2 2.8 2 1 1 3 3 3 2 MutS domain V MutS_III PF05192.18 EFW99922.1 - 1.3e-12 48.3 5.8 1.8e-12 47.9 0.9 2.2 1 1 1 2 2 2 1 MutS domain III MutS_II PF05188.17 EFW99922.1 - 7.4e-06 26.3 0.0 1.5e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 MutS domain II AAA_30 PF13604.6 EFW99922.1 - 0.0037 17.0 0.0 0.0093 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFW99922.1 - 0.0095 15.7 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFW99922.1 - 0.011 16.3 0.0 0.018 15.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 EFW99922.1 - 0.02 14.5 0.0 0.048 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain GCV_T_C PF08669.11 EFW99922.1 - 0.024 14.5 0.0 0.081 12.9 0.0 1.9 2 0 0 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain SMC_N PF02463.19 EFW99922.1 - 0.17 11.3 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DnaJ PF00226.31 EFW99923.1 - 1.7e-08 34.4 0.1 4.5e-08 33.1 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain SpoIIE PF07228.12 EFW99923.1 - 0.12 12.3 1.4 0.16 11.9 0.3 1.7 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Use1 PF09753.9 EFW99923.1 - 1.2 8.8 2.6 13 5.4 0.1 2.1 2 0 0 2 2 2 0 Membrane fusion protein Use1 Ada3 PF10198.9 EFW99923.1 - 8.3 6.6 7.3 0.6 10.3 1.1 2.1 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 Herpes_UL92 PF03048.14 EFW99924.1 - 0.072 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 UL92 family FAM153 PF15722.5 EFW99924.1 - 0.16 12.4 1.1 1.7 9.0 0.1 2.8 2 1 1 3 3 3 0 FAM153 family HpcH_HpaI PF03328.14 EFW99925.1 - 3.6e-39 134.2 0.2 4.8e-39 133.8 0.2 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family CBS PF00571.28 EFW99926.1 - 6.6e-17 61.7 3.3 3.1e-05 24.3 0.1 4.6 5 0 0 5 5 5 4 CBS domain DUF2828 PF11443.8 EFW99928.1 - 1.8e-77 261.0 0.0 2e-77 260.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Glyco_hydro_72 PF03198.14 EFW99928.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Aldo_ket_red PF00248.21 EFW99929.1 - 1.9e-35 122.5 0.0 4.3e-35 121.3 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family HET PF06985.11 EFW99930.1 - 2.6e-12 47.3 4.7 1.3e-08 35.4 1.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Asp PF00026.23 EFW99931.1 - 9.1e-52 176.4 6.7 3.4e-32 112.1 4.5 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFW99931.1 - 1e-10 42.1 1.7 1e-10 42.1 1.7 3.9 3 2 0 3 3 3 1 Xylanase inhibitor N-terminal Zip PF02535.22 EFW99932.1 - 1.2e-62 212.1 9.6 3.8e-62 210.4 9.6 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter RAI1 PF08652.11 EFW99933.1 - 3.3e-27 94.4 0.0 6.3e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease PfkB PF00294.24 EFW99934.1 - 4.9e-05 22.8 0.8 0.0038 16.6 0.6 2.7 3 0 0 3 3 3 2 pfkB family carbohydrate kinase PIG-L PF02585.17 EFW99935.1 - 3.8e-25 89.0 0.0 6.5e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase NatB_MDM20 PF09797.9 EFW99937.1 - 6.1e-53 180.1 0.0 1e-52 179.4 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit PTCB-BRCT PF12738.7 EFW99938.1 - 1.5e-45 153.0 1.0 2.9e-21 75.2 0.0 4.2 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 EFW99938.1 - 1.3e-33 115.2 0.0 6.1e-13 49.0 0.0 4.3 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFW99938.1 - 1.9e-16 60.3 0.0 6e-07 29.8 0.0 4.2 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFW99938.1 - 3.4e-09 36.9 2.9 0.0012 19.1 0.0 4.3 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EFW99938.1 - 0.00011 22.1 0.0 2 8.4 0.0 3.4 3 0 0 3 3 3 2 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EFW99938.1 - 0.00049 20.1 0.4 0.71 10.0 0.0 3.4 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Plug PF07715.15 EFW99938.1 - 0.035 14.7 0.0 0.087 13.4 0.0 1.6 1 0 0 1 1 1 0 TonB-dependent Receptor Plug Domain HET PF06985.11 EFW99939.1 - 4.1e-32 111.5 0.0 5.8e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Stealth_CR4 PF17103.5 EFW99939.1 - 0.14 12.1 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Methyltransf_2 PF00891.18 EFW99940.1 - 1.4e-16 60.4 0.0 4.5e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 O-methyltransferase domain Hexapep PF00132.24 EFW99941.1 - 8.8e-08 31.6 9.2 0.00088 18.9 0.6 3.8 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) W2 PF02020.18 EFW99941.1 - 1e-06 28.8 0.0 2.5e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 EFW99941.1 - 4.2e-05 23.3 0.0 6.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 EFW99941.1 - 0.00023 20.8 7.4 0.1 12.4 3.9 3.5 1 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EFW99941.1 - 0.0022 17.0 0.8 0.026 13.5 0.4 2.0 1 1 1 2 2 2 2 L-fucokinase NTP_transf_3 PF12804.7 EFW99941.1 - 0.0087 16.4 0.0 0.024 15.0 0.0 1.8 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EFW99941.1 - 0.88 7.6 2.0 2.1 6.4 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) IBR PF01485.21 EFW99942.1 - 4.8e-08 33.1 24.7 2.2e-05 24.6 10.3 2.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain Erv26 PF04148.13 EFW99943.1 - 4.7e-26 91.9 0.0 5.2e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 RRM_1 PF00076.22 EFW99944.1 - 9.2e-16 57.4 0.0 1.5e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EFW99944.1 - 0.002 18.6 38.4 0.029 14.9 35.5 3.5 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 CorA PF01544.18 EFW99945.1 - 3.7e-39 134.8 1.0 1.8e-18 66.9 0.2 2.4 3 0 0 3 3 3 2 CorA-like Mg2+ transporter protein DUF2514 PF10721.9 EFW99945.1 - 0.0037 17.3 1.4 0.0037 17.3 1.4 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2514) Rsc14 PF08586.10 EFW99945.1 - 0.0046 17.7 0.6 3.2 8.6 0.0 2.6 2 0 0 2 2 2 2 RSC complex, Rsc14/Ldb7 subunit Spt20 PF12090.8 EFW99945.1 - 0.4 10.3 4.1 0.73 9.4 4.1 1.4 1 0 0 1 1 1 0 Spt20 family Guanylate_kin PF00625.21 EFW99945.1 - 1.4 8.6 4.2 0.22 11.2 0.1 1.7 2 0 0 2 2 2 0 Guanylate kinase Serglycin PF04360.12 EFW99945.1 - 6 6.8 16.8 7 6.6 4.5 2.6 2 0 0 2 2 2 0 Serglycin SNF2_N PF00176.23 EFW99946.1 - 3.5e-65 220.0 0.0 6.1e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFW99946.1 - 8e-21 74.5 0.0 1.7e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99946.1 - 6.7e-05 23.0 0.0 0.00018 21.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFW99946.1 - 0.0066 15.7 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF3328 PF11807.8 EFW99947.1 - 1.4e-12 47.8 0.2 1.9e-12 47.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TPR_12 PF13424.6 EFW99948.1 - 1.2e-114 374.7 28.5 1.4e-19 70.1 0.1 7.6 1 1 7 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 EFW99948.1 - 1.9e-101 329.5 7.3 4e-14 51.9 0.1 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 EFW99948.1 - 1.1e-27 93.9 2.6 0.041 14.0 0.0 8.5 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 EFW99948.1 - 3.5e-27 92.4 8.7 0.004 17.1 0.0 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFW99948.1 - 2.8e-24 83.9 3.2 0.086 12.7 0.0 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 EFW99948.1 - 1.9e-23 82.8 4.0 0.00022 21.8 0.5 8.0 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFW99948.1 - 8.2e-21 74.3 0.2 0.0035 17.8 0.0 8.3 3 2 6 9 9 9 6 Tetratricopeptide repeat TPR_4 PF07721.14 EFW99948.1 - 1.8e-19 68.3 0.0 0.71 10.7 0.0 7.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 EFW99948.1 - 6.1e-17 60.7 0.6 0.27 11.7 0.0 7.8 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_MalT PF17874.1 EFW99948.1 - 8.6e-14 51.7 6.8 7.2e-09 35.5 3.1 2.4 1 1 0 2 2 2 2 MalT-like TPR region NB-ARC PF00931.22 EFW99948.1 - 3.4e-11 42.8 0.0 6.1e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_14 PF13428.6 EFW99948.1 - 6e-11 42.2 12.0 5.4 8.1 0.0 8.6 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFW99948.1 - 2.7e-10 40.2 7.1 1.9 9.3 0.0 8.5 8 0 0 8 8 7 1 Tetratricopeptide repeat PPR PF01535.20 EFW99948.1 - 1.6e-08 34.2 0.4 9.3 6.8 0.0 6.9 6 0 0 6 6 6 0 PPR repeat ANAPC3 PF12895.7 EFW99948.1 - 1.9e-08 34.4 2.2 1.9 8.8 0.0 6.5 1 1 6 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFW99948.1 - 9e-08 31.8 6.9 5.5 7.5 0.0 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat NACHT PF05729.12 EFW99948.1 - 8.5e-06 25.8 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFW99948.1 - 0.00017 21.8 0.0 0.001 19.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF1897 PF09005.10 EFW99948.1 - 0.0027 17.1 8.2 6 6.4 0.1 6.0 6 0 0 6 6 6 1 Domain of unknown function (DUF1897) PPR_1 PF12854.7 EFW99948.1 - 0.004 16.8 1.3 1.4e+02 2.3 0.0 5.9 6 0 0 6 6 6 0 PPR repeat TPR_5 PF12688.7 EFW99948.1 - 0.012 15.9 1.1 0.53 10.5 0.2 3.4 1 1 0 2 2 2 0 Tetratrico peptide repeat TPR_11 PF13414.6 EFW99948.1 - 0.015 15.0 2.6 1.8e+02 1.9 0.1 6.3 7 0 0 7 7 7 0 TPR repeat DUF2508 PF10704.9 EFW99948.1 - 0.07 13.3 3.0 1.1e+02 3.1 0.1 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2508) AAA_16 PF13191.6 EFW99948.1 - 0.17 12.2 1.8 1.4 9.2 0.3 2.9 2 1 0 2 2 1 0 AAA ATPase domain Gaa1 PF04114.14 EFW99949.1 - 6e-157 523.6 12.8 4.7e-111 372.3 0.6 3.0 3 0 0 3 3 3 2 Gaa1-like, GPI transamidase component Rhomboid PF01694.22 EFW99949.1 - 7.4e-13 48.8 12.7 7.4e-13 48.8 12.7 3.3 3 0 0 3 3 3 1 Rhomboid family Polysacc_deac_1 PF01522.21 EFW99950.1 - 2.1e-25 89.0 0.0 3.5e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Peptidase_A4 PF01828.17 EFW99951.1 - 6.5e-65 218.5 20.4 7.9e-65 218.2 20.4 1.1 1 0 0 1 1 1 1 Peptidase A4 family MF_alpha_N PF05436.11 EFW99951.1 - 0.051 13.5 0.9 0.2 11.6 0.1 2.2 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus BatD PF13584.6 EFW99952.1 - 0.02 13.7 0.2 0.026 13.4 0.2 1.1 1 0 0 1 1 1 0 Oxygen tolerance Mntp PF02659.15 EFW99952.1 - 0.031 14.0 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative manganese efflux pump DUF4381 PF14316.6 EFW99952.1 - 0.054 13.7 0.3 0.1 12.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF2628 PF10947.8 EFW99952.1 - 0.068 13.5 0.2 0.13 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Saf_2TM PF18303.1 EFW99952.1 - 0.13 11.8 0.1 0.18 11.4 0.1 1.1 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4231 PF14015.6 EFW99952.1 - 2.6 8.6 6.7 2.3 8.7 4.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) RRM_1 PF00076.22 EFW99953.1 - 6.9e-47 157.1 0.0 1.3e-16 60.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFW99953.1 - 5.6e-05 23.1 0.1 0.0022 18.0 0.1 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EFW99953.1 - 8.2e-05 22.6 0.0 0.0017 18.4 0.0 2.6 3 0 0 3 3 3 1 RNA binding motif RRM_7 PF16367.5 EFW99953.1 - 0.00017 21.6 0.1 0.052 13.7 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 EFW99953.1 - 0.00018 21.3 0.0 0.049 13.5 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EFW99953.1 - 0.029 14.0 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAA_hydrolase PF01557.18 EFW99954.1 - 1.4e-56 191.6 0.0 1.8e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EFW99954.1 - 7.5e-26 90.4 0.0 1.2e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal CN_hydrolase PF00795.22 EFW99955.1 - 1.9e-12 47.1 0.0 6.9e-12 45.3 0.0 1.8 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase IF-2B PF01008.17 EFW99958.1 - 3.3e-71 239.8 0.4 3.8e-71 239.6 0.4 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family MFS_1 PF07690.16 EFW99959.1 - 1.5e-38 132.6 37.3 1.4e-35 122.9 26.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.13 EFW99959.1 - 8.2e-21 74.6 0.0 1.3e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Sugar_tr PF00083.24 EFW99959.1 - 8.7e-12 44.6 4.0 8.7e-12 44.6 4.0 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter NAD_binding_10 PF13460.6 EFW99959.1 - 5.3e-11 42.8 0.1 9e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Esterase PF00756.20 EFW99959.1 - 2.3e-10 40.5 0.0 1.7e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EFW99959.1 - 0.00031 20.1 0.0 0.00062 19.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFW99959.1 - 0.00049 19.6 0.1 0.0013 18.2 0.1 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFW99959.1 - 0.026 14.2 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold MFS_1_like PF12832.7 EFW99959.1 - 0.41 9.5 8.8 0.034 13.0 0.5 2.4 2 0 0 2 2 2 0 MFS_1 like family DUF5325 PF17259.2 EFW99959.1 - 0.84 9.6 3.6 2 8.4 0.5 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5325) CAP_GLY PF01302.25 EFW99961.1 - 1.4e-14 53.8 0.4 3e-14 52.8 0.4 1.6 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EFW99961.1 - 9.4e-08 31.7 10.3 0.0007 19.4 1.3 2.6 2 0 0 2 2 2 2 CLIP1 zinc knuckle NPV_P10 PF05531.12 EFW99961.1 - 0.0026 18.2 4.1 0.57 10.7 0.9 2.7 2 0 0 2 2 2 2 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 EFW99961.1 - 0.0048 17.2 11.9 0.011 16.0 1.8 3.8 4 0 0 4 4 4 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_13 PF13166.6 EFW99961.1 - 0.0068 15.1 10.4 0.0098 14.6 8.6 1.8 2 0 0 2 2 2 1 AAA domain Med4 PF10018.9 EFW99961.1 - 0.016 14.9 0.1 0.016 14.9 0.1 3.5 4 0 0 4 4 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Glutaredoxin2_C PF04399.13 EFW99961.1 - 0.043 13.7 1.1 11 5.9 0.0 2.8 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain DUF241 PF03087.14 EFW99961.1 - 0.1 12.4 3.0 0.15 11.8 1.4 2.1 2 0 0 2 2 2 0 Arabidopsis protein of unknown function Spc7 PF08317.11 EFW99961.1 - 1 8.2 26.1 0.29 10.0 9.6 3.2 3 1 1 4 4 4 0 Spc7 kinetochore protein DUF3584 PF12128.8 EFW99961.1 - 1 6.8 17.9 2.1 5.7 14.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Fzo_mitofusin PF04799.13 EFW99961.1 - 1.1 8.8 7.0 0.59 9.7 1.5 2.7 2 0 0 2 2 2 0 fzo-like conserved region SHE3 PF17078.5 EFW99961.1 - 1.2 8.8 12.6 2.7 7.7 0.3 3.2 3 0 0 3 3 3 0 SWI5-dependent HO expression protein 3 FliD_N PF02465.18 EFW99961.1 - 1.7 9.4 7.3 13 6.5 0.0 3.8 4 0 0 4 4 3 0 Flagellar hook-associated protein 2 N-terminus Laminin_II PF06009.12 EFW99961.1 - 2 8.4 7.1 1.1 9.3 1.9 2.6 2 0 0 2 2 2 0 Laminin Domain II Phage_GP20 PF06810.11 EFW99961.1 - 2.1 8.2 13.6 4.9 7.0 0.1 3.5 2 1 1 3 3 3 0 Phage minor structural protein GP20 Fib_alpha PF08702.10 EFW99961.1 - 2.7 8.2 7.2 11 6.2 1.5 3.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EFW99961.1 - 3.1 8.1 3.8 2.4 8.5 0.7 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF3349 PF11829.8 EFW99961.1 - 3.3 8.6 5.0 1.7 9.5 2.0 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3349) LXG PF04740.12 EFW99961.1 - 3.7 7.2 8.1 11 5.7 1.8 3.0 3 0 0 3 3 3 0 LXG domain of WXG superfamily DUF4407 PF14362.6 EFW99961.1 - 6.5 6.0 27.8 0.034 13.5 0.8 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4407) DUF4618 PF15397.6 EFW99961.1 - 6.5 6.1 12.3 2.8 7.3 5.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) EzrA PF06160.12 EFW99961.1 - 7.1 4.7 12.0 1.3 7.1 6.7 2.1 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA FapA PF03961.13 EFW99961.1 - 9.9 4.6 7.3 2.1 6.9 3.4 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A WD40 PF00400.32 EFW99965.1 - 1.9e-26 91.7 18.6 0.00041 21.1 0.3 10.9 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFW99965.1 - 0.00062 20.0 0.1 2.1 8.7 0.1 5.6 5 3 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Pox_E10 PF04805.12 EFW99967.1 - 2.9 7.8 4.6 44 4.0 0.1 3.2 3 0 0 3 3 3 0 E10-like protein conserved region Abhydrolase_6 PF12697.7 EFW99968.1 - 4.3e-06 27.5 0.7 1.1e-05 26.1 0.7 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EFW99968.1 - 0.0013 18.6 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_1 PF00561.20 EFW99968.1 - 0.0038 16.9 0.1 0.0098 15.6 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 EFW99968.1 - 0.071 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Hydrolase_4 PF12146.8 EFW99969.1 - 4.2e-18 65.5 0.1 6.1e-13 48.6 0.1 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFW99969.1 - 1.9e-09 37.6 0.3 1.2e-05 25.1 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFW99969.1 - 5.2e-06 27.2 0.1 8.5e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF818 PF05677.12 EFW99969.1 - 7e-06 25.2 0.0 9.8e-06 24.7 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.13 EFW99969.1 - 7.9e-05 22.4 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 EFW99969.1 - 0.0012 18.4 0.0 0.7 9.4 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family AXE1 PF05448.12 EFW99969.1 - 0.0019 16.9 0.7 0.12 11.0 0.1 2.9 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 EFW99969.1 - 0.0024 17.4 0.0 0.027 13.9 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Thioesterase PF00975.20 EFW99969.1 - 0.039 14.1 0.1 0.075 13.1 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain BAAT_C PF08840.11 EFW99969.1 - 0.04 13.8 0.0 9.9 6.0 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 EFW99969.1 - 0.048 13.5 0.3 0.11 12.4 0.3 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EFW99969.1 - 0.073 12.8 0.0 0.2 11.4 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EFW99969.1 - 0.073 12.9 0.3 4.2 7.1 0.0 2.7 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase zf-U11-48K PF05253.12 EFW99969.1 - 0.082 12.9 0.2 0.31 11.0 0.1 2.0 2 0 0 2 2 2 0 U11-48K-like CHHC zinc finger Fungal_trans PF04082.18 EFW99970.1 - 4e-15 55.6 0.7 7.3e-15 54.7 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Rsa3 PF14615.6 EFW99971.1 - 7.6e-15 54.2 0.6 1.1e-08 34.5 0.3 2.1 2 0 0 2 2 2 2 Ribosome-assembly protein 3 SMI1_KNR4 PF09346.10 EFW99972.1 - 2.7e-31 108.7 0.0 7.3e-31 107.3 0.0 1.8 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) BRF1 PF07741.13 EFW99972.1 - 0.065 13.6 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 Brf1-like TBP-binding domain CVNH PF08881.10 EFW99973.1 - 4.6e-07 30.5 0.5 6.3e-07 30.0 0.5 1.2 1 0 0 1 1 1 1 CVNH domain Formyl_trans_N PF00551.19 EFW99974.1 - 1.7e-35 122.4 0.0 2.4e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase MCM PF00493.23 EFW99975.1 - 8.8e-104 345.5 0.0 1.3e-103 345.0 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFW99975.1 - 2.9e-28 98.2 0.1 5e-28 97.5 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFW99975.1 - 1.9e-20 73.1 1.1 3.9e-20 72.1 1.1 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFW99975.1 - 1.2e-16 61.1 0.1 3.8e-16 59.6 0.1 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFW99975.1 - 2e-07 30.6 0.0 1.8e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFW99975.1 - 1.2e-06 28.6 0.0 3.8e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFW99975.1 - 0.012 15.4 0.0 0.038 13.9 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 EFW99975.1 - 0.054 14.1 0.3 0.054 14.1 0.3 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Sigma54_activat PF00158.26 EFW99975.1 - 0.17 11.6 0.1 0.8 9.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain DER1 PF04511.15 EFW99976.1 - 4e-15 56.3 2.3 5e-15 55.9 1.6 1.4 1 1 1 2 2 2 1 Der1-like family zf-LYAR PF08790.11 EFW99977.1 - 3.7e-14 52.3 5.0 3.7e-14 52.3 5.0 2.0 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger GCIP PF13324.6 EFW99977.1 - 0.081 12.5 0.2 0.15 11.6 0.2 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF3292 PF11696.8 EFW99977.1 - 1.1 7.5 5.4 2 6.7 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Ytp1 PF10355.9 EFW99978.1 - 1.5e-117 391.7 5.8 1.5e-117 391.7 5.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EFW99978.1 - 5.8e-30 103.2 5.6 5.8e-30 103.2 5.6 3.6 4 0 0 4 4 4 2 Domain of unknown function (DUF2427) MFS_1 PF07690.16 EFW99979.1 - 7.2e-05 21.9 1.7 9.5e-05 21.5 1.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sel1 PF08238.12 EFW99980.1 - 2.3e-09 37.6 0.3 6.7e-05 23.4 0.0 2.7 2 0 0 2 2 2 2 Sel1 repeat SDP_N PF12278.8 EFW99980.1 - 0.013 15.6 0.7 0.013 15.6 0.7 2.4 3 0 0 3 3 3 0 Sex determination protein N terminal RSB_motif PF16294.5 EFW99980.1 - 3.4 8.0 9.8 1.1 9.6 2.9 2.5 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif PI-PLC-X PF00388.19 EFW99981.1 - 5e-62 207.8 0.0 9e-62 206.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFW99981.1 - 1.4e-37 128.6 0.1 3.1e-37 127.4 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EFW99981.1 - 1.2e-06 28.7 0.0 3.8e-06 27.1 0.0 1.9 1 1 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 EFW99981.1 - 0.018 15.5 0.0 0.039 14.4 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like PH_12 PF16457.5 EFW99981.1 - 0.028 15.0 0.2 0.076 13.5 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain Cupin_5 PF06172.11 EFW99982.1 - 1.1e-47 161.8 0.0 1.4e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) SNF2_N PF00176.23 EFW99983.1 - 2.2e-65 220.7 0.3 3.5e-65 220.0 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFW99983.1 - 9.4e-18 64.6 0.1 1.9e-17 63.6 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFW99983.1 - 1.9e-09 37.8 0.0 3.5e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.13 EFW99983.1 - 0.00026 21.3 3.7 0.00026 21.3 3.7 2.6 2 0 0 2 2 2 1 HSA HDA2-3 PF11496.8 EFW99983.1 - 0.029 13.5 0.1 2.2 7.4 0.0 2.5 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Cpn60_TCP1 PF00118.24 EFW99984.1 - 2e-135 452.2 9.8 2.4e-135 452.0 9.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5442 PF17514.2 EFW99984.1 - 0.031 14.5 0.1 0.076 13.2 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5442) CRM1_repeat PF18777.1 EFW99984.1 - 0.097 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat DUF1838 PF08894.11 EFW99985.1 - 0.034 13.8 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1838) Fes1 PF08609.10 EFW99986.1 - 4.7e-28 97.9 1.1 9.2e-28 97.0 0.4 1.8 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 Arm PF00514.23 EFW99986.1 - 6.5e-06 26.0 0.5 0.0057 16.7 0.0 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFW99986.1 - 0.00028 21.3 3.1 0.00053 20.4 1.5 2.5 2 0 0 2 2 2 1 HEAT-like repeat HEAT_2 PF13646.6 EFW99986.1 - 0.00074 19.9 1.3 0.00074 19.9 1.3 2.3 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 EFW99986.1 - 0.2 12.0 2.8 12 6.5 0.1 3.3 3 1 0 3 3 3 0 HEAT repeat ATP13 PF12921.7 EFW99987.1 - 1.7e-22 79.4 0.1 1.1e-21 76.8 0.0 2.4 3 0 0 3 3 3 1 Mitochondrial ATPase expression OmdA PF13376.6 EFW99987.1 - 0.012 15.6 0.2 0.056 13.5 0.0 2.1 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated Rota_NSP3 PF01665.16 EFW99987.1 - 0.25 10.4 0.0 0.53 9.4 0.0 1.4 2 0 0 2 2 2 0 Rotavirus non-structural protein NSP3 ABATE PF07336.11 EFW99987.1 - 0.94 10.2 6.1 0.25 12.0 0.8 2.5 2 0 0 2 2 2 0 Putative stress-induced transcription regulator SAC3_GANP PF03399.16 EFW99988.1 - 1.4e-94 316.7 0.0 2.2e-94 316.1 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EFW99988.1 - 0.023 14.7 0.0 0.071 13.1 0.0 1.8 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family SUIM_assoc PF16619.5 EFW99988.1 - 0.23 11.5 3.6 2.8 8.1 3.6 3.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PROCN PF08083.11 EFW99989.1 - 1.4e-228 758.5 8.1 1.4e-228 758.5 8.1 1.8 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EFW99989.1 - 7.6e-126 418.3 0.9 1.4e-125 417.5 0.9 1.5 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EFW99989.1 - 5e-83 276.8 1.5 1.1e-56 191.2 0.1 3.4 3 0 0 3 3 3 2 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EFW99989.1 - 1.5e-80 268.5 2.7 3.8e-80 267.2 2.7 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EFW99989.1 - 3.6e-71 237.5 0.1 7.8e-71 236.4 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EFW99989.1 - 4.3e-46 155.2 0.1 1.1e-45 153.9 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EFW99989.1 - 6.7e-43 145.5 0.5 1.5e-42 144.4 0.0 1.9 2 0 0 2 2 2 1 PROCT (NUC072) domain Hom_end_hint PF05203.16 EFW99989.1 - 1.1e-08 35.4 0.0 1.7e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 Hom_end-associated Hint WBS_methylT PF12589.8 EFW99991.1 - 2.2e-13 50.8 3.1 4.1e-13 49.9 3.1 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EFW99991.1 - 3.8e-08 33.9 0.0 6.7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW99991.1 - 8e-06 26.5 0.0 2.2e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99991.1 - 0.035 14.8 0.0 0.085 13.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Glyco_transf_24 PF18404.1 EFW99992.1 - 7.9e-143 474.7 0.4 1.2e-142 474.1 0.4 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EFW99992.1 - 1.1e-66 225.4 0.0 2.2e-65 221.1 0.0 2.6 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EFW99992.1 - 2.8e-51 174.5 0.1 3.5e-49 167.6 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EFW99992.1 - 8.5e-49 166.0 0.6 2.1e-48 164.7 0.1 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EFW99992.1 - 3.7e-45 153.2 0.1 7e-43 145.8 0.1 3.1 3 0 0 3 3 3 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EFW99992.1 - 9e-34 115.9 0.0 1.7e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EFW99992.1 - 2.1e-05 24.2 0.1 3.6e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 TruB_C PF09142.11 EFW99992.1 - 0.07 12.9 0.4 1.5 8.6 0.0 3.0 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Metallopep PF12044.8 EFW99993.1 - 2.5e-161 537.0 0.0 3.2e-161 536.7 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 EFW99993.1 - 0.0005 20.0 0.0 0.0009 19.2 0.0 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain Peptidase_M10 PF00413.24 EFW99993.1 - 0.041 13.7 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 Matrixin SQS_PSY PF00494.19 EFW99994.1 - 6.7e-59 199.5 3.4 9.3e-59 199.1 3.4 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Utp8 PF10395.9 EFW99995.1 - 7.8e-06 24.7 0.0 5.2e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 Utp8 family LSM PF01423.22 EFW99996.1 - 4.2e-18 64.8 0.3 6.3e-18 64.2 0.3 1.3 1 1 0 1 1 1 1 LSM domain Ribosomal_S3Ae PF01015.18 EFW99996.1 - 0.23 11.0 0.2 0.29 10.7 0.2 1.1 1 0 0 1 1 1 0 Ribosomal S3Ae family zf-C3HC4_3 PF13920.6 EFW99997.1 - 8.6e-07 28.7 9.9 8.6e-07 28.7 9.9 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFW99997.1 - 0.0019 18.0 11.6 0.0019 18.0 11.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF3071 PF11268.8 EFW99997.1 - 0.057 13.5 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Peptidase_C6 PF00851.18 EFW99997.1 - 0.28 10.0 1.4 0.45 9.4 1.4 1.2 1 0 0 1 1 1 0 Helper component proteinase zf-RING_2 PF13639.6 EFW99997.1 - 8.3 6.8 28.8 0.027 14.8 12.0 3.1 3 0 0 3 3 3 0 Ring finger domain Na_Ca_ex PF01699.24 EFW99998.1 - 3.2e-32 111.6 44.4 6.4e-21 74.9 17.8 3.0 3 1 0 3 3 3 2 Sodium/calcium exchanger protein SR-25 PF10500.9 EFW99998.1 - 0.035 13.7 13.1 0.4 10.2 8.2 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein BioT2 PF15368.6 EFW99998.1 - 0.043 13.8 0.3 0.11 12.5 0.3 1.6 1 0 0 1 1 1 0 Spermatogenesis family BioT2 Methyltransf_11 PF08241.12 EFW99999.1 - 5.3e-19 68.7 0.0 1e-18 67.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFW99999.1 - 5.5e-19 68.7 0.0 1.1e-18 67.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFW99999.1 - 6.1e-15 55.3 0.0 9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFW99999.1 - 1.6e-13 51.2 0.0 2.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFW99999.1 - 1e-12 47.9 0.0 2.1e-12 46.9 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFW99999.1 - 1.4e-10 41.3 0.0 2.3e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFW99999.1 - 4.2e-10 39.4 0.0 6.1e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EFW99999.1 - 2.4e-05 23.9 0.0 4.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFW99999.1 - 0.00029 20.3 0.0 0.00051 19.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 EFW99999.1 - 0.00035 20.2 0.0 0.00062 19.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 EFW99999.1 - 0.0014 18.4 0.0 0.0023 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EFW99999.1 - 0.0081 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase RrnaAD PF00398.20 EFW99999.1 - 0.014 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_8 PF05148.15 EFW99999.1 - 0.022 14.6 0.0 0.26 11.1 0.0 2.2 1 1 0 1 1 1 0 Hypothetical methyltransferase DOT1 PF08123.13 EFW99999.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 ADH_zinc_N PF00107.26 EFW99999.1 - 0.068 13.2 0.0 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_18 PF12847.7 EFW99999.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFW99999.1 - 0.092 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Mito_fiss_Elm1 PF06258.11 EFW99999.1 - 0.17 11.0 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission ELM1 SKG6 PF08693.10 EFX00001.1 - 0.048 13.1 4.8 0.09 12.2 4.8 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RSN1_7TM PF02714.15 EFX00002.1 - 3e-76 256.3 19.4 5.1e-76 255.6 19.4 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate 2-Hacid_dh_C PF02826.19 EFX00002.1 - 1.9e-47 161.0 0.3 4e-30 104.5 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RSN1_TM PF13967.6 EFX00002.1 - 6.3e-37 126.7 5.1 6.3e-37 126.7 5.1 2.7 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFX00002.1 - 2e-34 119.4 0.0 3.1e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter 2-Hacid_dh PF00389.30 EFX00002.1 - 2.8e-24 85.3 0.0 5.9e-24 84.2 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain DUF5313 PF17240.2 EFX00002.1 - 2.8 8.4 5.8 0.69 10.4 1.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5313) AAA PF00004.29 EFX00003.1 - 2e-51 173.9 0.0 2.6e-42 144.4 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EFX00003.1 - 1e-26 93.1 0.9 2.1e-26 92.1 0.9 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EFX00003.1 - 2.6e-13 49.6 8.8 4.2e-09 36.1 0.4 3.0 3 0 0 3 3 2 2 AAA+ lid domain AAA_16 PF13191.6 EFX00003.1 - 2.2e-07 31.4 15.7 0.00011 22.7 0.1 5.0 3 3 1 5 5 4 2 AAA ATPase domain AAA_5 PF07728.14 EFX00003.1 - 8.9e-06 25.7 0.1 0.031 14.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFX00003.1 - 1e-05 25.1 0.0 0.00013 21.6 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 EFX00003.1 - 0.00017 21.6 1.3 0.027 14.4 0.0 3.2 3 1 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 EFX00003.1 - 0.00022 21.5 2.6 0.43 10.8 0.2 3.7 2 2 1 3 3 3 2 AAA domain TsaE PF02367.17 EFX00003.1 - 0.00038 20.5 0.0 0.19 11.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EFX00003.1 - 0.00073 19.7 0.2 0.87 9.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFX00003.1 - 0.0011 18.8 0.0 0.031 14.0 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFX00003.1 - 0.0012 19.4 0.1 0.88 10.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain KAP_NTPase PF07693.14 EFX00003.1 - 0.0015 17.8 0.9 0.15 11.3 0.0 2.3 1 1 1 2 2 2 1 KAP family P-loop domain IstB_IS21 PF01695.17 EFX00003.1 - 0.0018 18.1 0.2 0.47 10.2 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 EFX00003.1 - 0.0044 17.2 0.0 0.57 10.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 EFX00003.1 - 0.0099 15.5 3.4 1.3 8.5 0.1 3.9 4 1 0 4 4 3 1 AAA domain Mg_chelatase PF01078.21 EFX00003.1 - 0.014 14.8 0.4 3 7.2 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EFX00003.1 - 0.016 14.5 0.1 1 8.6 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin TIP49 PF06068.13 EFX00003.1 - 0.018 14.3 0.1 4.1 6.5 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain Peptidase_M41 PF01434.18 EFX00003.1 - 0.019 14.8 0.1 0.033 14.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M41 Utp14 PF04615.13 EFX00003.1 - 0.025 13.2 1.8 0.041 12.5 1.8 1.2 1 0 0 1 1 1 0 Utp14 protein PEX-2N PF09263.10 EFX00003.1 - 0.03 14.6 0.1 5.2 7.4 0.0 2.8 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal DUF815 PF05673.13 EFX00003.1 - 0.032 13.4 0.0 0.18 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EFX00003.1 - 0.042 14.2 0.0 16 5.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 EFX00003.1 - 0.052 13.3 0.0 0.63 9.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 EFX00003.1 - 0.084 12.2 0.2 6.6 6.0 0.0 2.4 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 EFX00003.1 - 0.1 13.1 0.1 6.3 7.3 0.1 2.7 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 EFX00003.1 - 0.11 12.3 0.1 0.76 9.6 0.2 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain DAP3 PF10236.9 EFX00003.1 - 0.13 11.5 0.4 2 7.5 0.0 2.6 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 APS_kinase PF01583.20 EFX00003.1 - 0.16 11.9 0.3 0.43 10.5 0.1 1.9 2 0 0 2 2 1 0 Adenylylsulphate kinase RXT2_N PF08595.11 EFX00003.1 - 0.29 11.2 0.6 0.57 10.2 0.6 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Cylicin_N PF15241.6 EFX00003.1 - 0.41 10.8 1.0 1.2 9.3 1.0 1.7 1 0 0 1 1 1 0 Cylicin N-terminus p450 PF00067.22 EFX00004.1 - 3.6e-44 151.3 0.0 1.3e-30 106.6 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 DUF4424 PF14415.6 EFX00004.1 - 0.17 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4424) CRAL_TRIO PF00650.20 EFX00005.1 - 1.8e-13 50.5 0.0 2.9e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFX00005.1 - 0.0076 16.4 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFX00005.1 - 0.058 13.6 0.0 0.1 12.7 0.0 1.5 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain Asp PF00026.23 EFX00006.1 - 9.7e-37 127.1 2.3 1.1e-36 126.9 2.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX00006.1 - 2.3e-09 37.8 3.6 6.2e-09 36.3 3.6 1.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal IcmF_C PF06744.12 EFX00006.1 - 0.053 13.1 0.1 0.074 12.7 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal Iso_dh PF00180.20 EFX00007.1 - 9.7e-81 271.6 0.0 1.2e-80 271.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pneumo_att_G PF05539.11 EFX00008.1 - 0.64 9.6 7.0 1 8.9 7.0 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G NDUF_B8 PF05821.11 EFX00009.1 - 2.1e-06 27.7 0.1 2.6e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) SesA PF17107.5 EFX00011.1 - 0.0017 18.6 0.1 0.0089 16.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Elongin_A PF06881.11 EFX00012.1 - 6.7e-26 90.9 0.1 1.5e-25 89.8 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A CBF PF03914.17 EFX00014.1 - 9.1e-36 123.5 0.7 2.8e-34 118.6 0.2 2.9 2 1 1 3 3 3 1 CBF/Mak21 family Qua1 PF16274.5 EFX00014.1 - 0.085 12.7 0.1 0.22 11.4 0.1 1.7 1 0 0 1 1 1 0 Qua1 domain GyrI-like PF06445.15 EFX00014.1 - 0.094 13.0 0.0 0.79 10.0 0.0 2.2 2 0 0 2 2 2 0 GyrI-like small molecule binding domain Tyrosinase PF00264.20 EFX00015.1 - 1.1e-50 173.1 5.6 3.5e-50 171.3 5.6 1.9 1 1 0 1 1 1 1 Common central domain of tyrosinase Ivy PF08816.11 EFX00015.1 - 0.064 13.5 0.8 7.8 6.7 0.0 2.5 2 0 0 2 2 2 0 Inhibitor of vertebrate lysozyme (Ivy) Cyclin PF08613.11 EFX00016.1 - 6.3e-43 146.9 1.7 4.1e-25 89.0 0.3 2.4 2 0 0 2 2 2 2 Cyclin hDGE_amylase PF14701.6 EFX00018.1 - 3.3e-176 586.7 0.0 4.2e-176 586.4 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EFX00018.1 - 6.2e-117 390.8 0.0 1e-116 390.1 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EFX00018.1 - 3.8e-87 292.1 0.0 7.7e-87 291.1 0.0 1.5 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EFX00018.1 - 3.5e-31 107.2 0.0 7.3e-31 106.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme P_proprotein PF01483.20 EFX00018.1 - 0.023 14.7 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 Proprotein convertase P-domain Alpha-amylase PF00128.24 EFX00018.1 - 0.094 12.3 0.0 0.7 9.4 0.0 2.0 2 0 0 2 2 2 0 Alpha amylase, catalytic domain Zw10 PF06248.13 EFX00019.1 - 1.3e-09 37.2 0.1 0.0013 17.4 0.4 2.8 3 0 0 3 3 3 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EFX00019.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal MIF4G_like PF09088.11 EFX00021.1 - 1.2e-86 289.4 0.7 2e-86 288.6 0.7 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EFX00021.1 - 2.6e-63 214.0 0.6 4e-63 213.4 0.6 1.3 1 0 0 1 1 1 1 MIF4G like APH PF01636.23 EFX00022.1 - 1.5e-06 28.4 0.5 6.1e-05 23.1 0.1 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFX00022.1 - 3.6e-06 26.5 0.1 8.6e-06 25.2 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFX00022.1 - 0.032 13.8 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EFX00022.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.6 1 1 0 1 1 1 0 Protein kinase domain FAD_binding_4 PF01565.23 EFX00023.1 - 2.2e-27 95.5 0.7 4.1e-27 94.6 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX00023.1 - 1.7e-12 47.3 0.2 4.1e-12 46.0 0.2 1.7 1 0 0 1 1 1 1 Berberine and berberine like REV1_C PF16727.5 EFX00023.1 - 0.042 14.3 0.2 0.1 13.0 0.2 1.6 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain NAD_Gly3P_dh_N PF01210.23 EFX00025.1 - 8e-46 155.9 0.0 1.6e-45 154.9 0.0 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EFX00025.1 - 9.4e-43 145.9 0.1 1.6e-42 145.2 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus HTH_ParB PF17762.1 EFX00025.1 - 0.15 11.9 0.4 1 9.2 0.1 2.3 3 0 0 3 3 3 0 HTH domain found in ParB protein PilP PF04351.13 EFX00026.1 - 0.0077 16.2 0.4 0.014 15.3 0.4 1.4 1 1 0 1 1 1 1 Pilus assembly protein, PilP Phyto_Pns9_10 PF05878.11 EFX00027.1 - 0.017 14.3 0.0 0.023 13.9 0.0 1.1 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Cyanate_lyase PF02560.14 EFX00028.1 - 2.1e-26 91.5 0.0 3e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 EFX00028.1 - 4.4e-08 33.3 0.4 6.5e-08 32.8 0.4 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 EFX00028.1 - 0.0008 19.4 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix Sigma70_r4_2 PF08281.12 EFX00028.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DUF640 PF04852.12 EFX00028.1 - 0.022 14.9 0.0 0.03 14.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF640) RPAP1_N PF08621.10 EFX00028.1 - 0.2 11.5 0.1 0.35 10.7 0.1 1.4 1 0 0 1 1 1 0 RPAP1-like, N-terminal ADH_N PF08240.12 EFX00029.1 - 2.7e-29 101.2 1.0 5.6e-29 100.2 1.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX00029.1 - 5.8e-14 52.2 0.3 5.8e-14 52.2 0.3 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX00029.1 - 0.0067 15.9 2.2 0.44 10.0 2.2 2.3 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus 2-Hacid_dh_C PF02826.19 EFX00029.1 - 0.073 12.4 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SNF2_N PF00176.23 EFX00030.1 - 2.2e-72 243.7 0.0 3e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EFX00030.1 - 7.2e-24 83.5 0.0 1.3e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EFX00030.1 - 3.3e-14 53.2 0.0 7e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EFX00030.1 - 0.00082 19.2 6.0 0.00082 19.2 6.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EFX00030.1 - 0.0026 17.8 0.0 0.0059 16.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EFX00030.1 - 0.003 17.4 9.7 0.003 17.4 9.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX00030.1 - 0.0077 16.1 8.6 0.0077 16.1 8.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UBA PF00627.31 EFX00030.1 - 0.078 12.9 0.5 4.7 7.2 0.1 2.5 2 0 0 2 2 2 0 UBA/TS-N domain ERCC3_RAD25_C PF16203.5 EFX00030.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-RING_2 PF13639.6 EFX00030.1 - 1.3 9.4 18.7 0.03 14.6 11.4 2.1 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 EFX00030.1 - 4.5 7.4 16.9 0.073 13.1 9.7 1.8 2 0 0 2 2 2 0 RING-type zinc-finger SUR7 PF06687.12 EFX00031.1 - 9.6e-07 28.6 4.7 1.8e-06 27.8 4.7 1.5 1 1 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EFX00031.1 - 1.3e-06 28.5 11.8 1.3e-06 28.5 11.8 2.1 1 1 1 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 WD40 PF00400.32 EFX00034.1 - 5.9e-29 99.7 10.4 2.6e-07 31.2 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX00034.1 - 4.2e-11 43.0 0.0 0.00013 22.2 0.2 4.4 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX00034.1 - 0.00016 21.6 0.0 0.1 12.4 0.0 2.3 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFX00034.1 - 0.00027 20.0 0.3 0.96 8.3 0.0 3.0 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFX00034.1 - 0.0021 17.4 0.0 0.079 12.3 0.0 2.5 2 1 1 3 3 3 2 WD40-like domain Aa_trans PF01490.18 EFX00035.1 - 3.2e-59 200.7 31.3 4.2e-59 200.3 31.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MerC PF03203.14 EFX00035.1 - 0.024 15.1 2.8 0.024 15.1 2.8 3.4 3 1 1 4 4 4 0 MerC mercury resistance protein DUF2075 PF09848.9 EFX00036.1 - 2.1e-95 320.1 0.0 2.9e-95 319.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EFX00036.1 - 8.3e-08 32.6 1.0 2.7e-07 30.9 0.3 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX00036.1 - 2.4e-05 24.8 1.3 6.8e-05 23.3 0.6 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EFX00036.1 - 0.00022 21.0 0.2 0.00072 19.3 0.2 1.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFX00036.1 - 0.00022 21.2 0.2 0.00043 20.2 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase ResIII PF04851.15 EFX00036.1 - 0.00047 20.2 0.0 0.052 13.6 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 EFX00036.1 - 0.0099 16.3 0.5 0.044 14.2 0.5 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EFX00036.1 - 0.013 14.6 0.1 0.02 14.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein KAP_NTPase PF07693.14 EFX00036.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain NACHT PF05729.12 EFX00036.1 - 0.028 14.4 0.1 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 NACHT domain PIF1 PF05970.14 EFX00036.1 - 0.033 13.4 0.0 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase AAA_19 PF13245.6 EFX00036.1 - 0.036 14.4 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFX00036.1 - 0.049 13.4 0.0 0.049 13.4 0.0 2.4 2 1 1 3 3 3 0 AAA domain ABC_tran PF00005.27 EFX00036.1 - 0.054 14.0 0.6 0.2 12.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 EFX00036.1 - 0.054 12.8 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 EFX00036.1 - 0.056 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Septin PF00735.18 EFX00036.1 - 0.064 12.5 0.3 0.1 11.8 0.3 1.2 1 0 0 1 1 1 0 Septin Sigma54_activat PF00158.26 EFX00036.1 - 0.082 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 EFX00036.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region 5_nucleotid_C PF02872.18 EFX00037.1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain IPP-2 PF04979.14 EFX00038.1 - 3.9e-24 85.9 4.9 3.9e-24 85.9 4.9 1.7 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) HAUS-augmin3 PF14932.6 EFX00040.1 - 0.00085 19.0 1.6 0.0016 18.1 1.6 1.5 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 NPV_P10 PF05531.12 EFX00040.1 - 0.032 14.7 1.6 2.4 8.7 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ApoLp-III PF07464.11 EFX00040.1 - 0.11 12.6 1.6 0.82 9.8 0.6 2.9 2 1 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Transcrip_act PF04949.13 EFX00040.1 - 0.14 12.0 1.4 0.41 10.5 0.0 2.4 3 0 0 3 3 3 0 Transcriptional activator Apolipoprotein PF01442.18 EFX00040.1 - 0.28 11.0 10.5 4.2 7.2 7.8 2.9 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain 2-Hacid_dh_C PF02826.19 EFX00041.1 - 2.7e-38 131.1 0.0 4.1e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TAFII28 PF04719.14 EFX00041.1 - 2.3e-17 62.9 0.0 4.2e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region 2-Hacid_dh PF00389.30 EFX00041.1 - 1e-08 34.9 0.0 1.8e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFX00041.1 - 2.2e-07 31.2 0.0 5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GFO_IDH_MocA PF01408.22 EFX00041.1 - 0.052 14.4 0.0 0.15 12.9 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Efg1 PF10153.9 EFX00043.1 - 1.7e-30 105.7 8.5 1.7e-30 105.7 8.5 2.5 2 0 0 2 2 2 1 rRNA-processing protein Efg1 DND1_DSRM PF14709.7 EFX00043.1 - 0.051 13.8 0.0 0.25 11.6 0.0 2.2 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 HET PF06985.11 EFX00045.1 - 7.3e-13 49.1 0.0 1.4e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TPR_19 PF14559.6 EFX00046.1 - 0.0063 17.0 6.0 0.018 15.5 0.0 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFX00046.1 - 4 7.6 9.7 0.38 10.9 0.9 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat C1_1 PF00130.22 EFX00047.1 - 0.2 11.5 8.2 0.44 10.5 8.2 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ketoacyl-synt PF00109.26 EFX00048.1 - 8.8e-59 199.1 11.2 4.8e-58 196.7 5.0 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFX00048.1 - 6.8e-37 126.1 0.6 1.3e-36 125.1 0.6 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Ubiq_cyt_C_chap PF03981.12 EFX00048.1 - 1.5e-34 119.1 0.5 3.5e-34 117.9 0.5 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Thiolase_N PF00108.23 EFX00048.1 - 2.9e-05 23.6 2.7 3.4e-05 23.3 0.5 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EFX00048.1 - 0.0064 16.9 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_C PF02803.18 EFX00048.1 - 0.045 13.4 0.1 0.045 13.4 0.1 3.5 3 1 1 4 4 4 0 Thiolase, C-terminal domain Dus PF01207.17 EFX00049.1 - 4.4e-57 193.5 0.0 8.1e-57 192.7 0.0 1.4 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Glyco_hydro_3_C PF01915.22 EFX00050.1 - 2.6e-45 154.9 0.0 4.1e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX00050.1 - 8.5e-34 117.4 0.0 2.1e-33 116.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX00050.1 - 2.2e-23 82.1 0.1 3.9e-23 81.3 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Peptidase_C2 PF00648.21 EFX00051.1 - 1.7e-31 109.4 0.0 2.8e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EFX00051.1 - 5.2e-06 26.8 0.0 0.12 12.6 0.0 3.5 3 0 0 3 3 3 2 Calpain large subunit, domain III MIT PF04212.18 EFX00051.1 - 0.028 14.5 0.1 0.061 13.4 0.1 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain ORC6 PF05460.13 EFX00053.1 - 0.12 11.6 6.8 0.17 11.1 6.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Med19 PF10278.9 EFX00053.1 - 2.9 7.8 10.0 4.6 7.1 10.0 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 MDM1 PF15501.6 EFX00053.1 - 3.9 6.5 16.3 5.7 6.0 16.3 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 4HBT_2 PF13279.6 EFX00054.1 - 2e-21 76.7 0.1 3.2e-21 76.1 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Ribosomal_L28e PF01778.17 EFX00056.1 - 9.7e-36 123.0 1.2 1.4e-35 122.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EFX00056.1 - 1.3e-28 99.5 3.1 1.3e-28 99.5 3.1 2.4 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EFX00056.1 - 1.2e-06 28.2 10.2 1.4e-06 27.9 10.2 1.1 1 0 0 1 1 1 1 BUD22 SDA1 PF05285.12 EFX00056.1 - 0.092 12.2 17.9 0.13 11.7 17.9 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFX00056.1 - 0.13 10.5 21.4 0.19 9.9 21.4 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EFX00056.1 - 0.53 9.6 15.5 0.9 8.8 15.5 1.5 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 EFX00056.1 - 0.72 9.9 26.0 0.024 14.8 16.5 2.1 2 0 0 2 2 2 0 YL1 nuclear protein Pox_RNA_Pol_19 PF05320.12 EFX00056.1 - 0.73 9.8 5.8 1.4 8.9 5.8 1.5 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF2462 PF09495.10 EFX00056.1 - 1.1 10.0 13.6 5.4 7.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2462) TFIIF_alpha PF05793.12 EFX00056.1 - 2.4 6.7 23.4 4 5.9 23.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RPN2_C PF18004.1 EFX00056.1 - 4.7 7.1 10.5 0.9 9.4 4.1 2.6 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain SAPS PF04499.15 EFX00056.1 - 8.2 5.1 7.0 11 4.7 7.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GCIP PF13324.6 EFX00056.1 - 8.3 5.9 10.0 14 5.2 10.0 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting K_trans PF02705.16 EFX00057.1 - 2.1e-177 590.9 16.1 2.4e-177 590.7 16.1 1.0 1 0 0 1 1 1 1 K+ potassium transporter UPF0020 PF01170.18 EFX00058.1 - 3.7e-07 30.0 0.1 0.0022 17.7 0.1 2.5 2 1 0 2 2 2 2 Putative RNA methylase family UPF0020 Ldh_1_C PF02866.18 EFX00059.1 - 9.7e-47 159.0 0.0 1.4e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFX00059.1 - 3.4e-43 147.1 0.4 4.7e-43 146.7 0.4 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EFX00059.1 - 0.0013 17.8 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ketoacyl-synt PF00109.26 EFX00060.1 - 1e-71 241.5 0.0 2.3e-71 240.3 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EFX00060.1 - 4.7e-67 225.4 0.5 1e-66 224.3 0.5 1.6 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 EFX00060.1 - 2.3e-57 194.9 0.9 4.5e-57 194.0 0.9 1.5 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EFX00060.1 - 3e-56 190.9 2.6 6.9e-56 189.7 2.6 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EFX00060.1 - 1.7e-40 137.7 0.0 4.8e-40 136.3 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFX00060.1 - 9.8e-20 71.1 0.0 1.4e-18 67.3 0.0 2.8 3 0 0 3 3 2 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EFX00060.1 - 4e-19 70.0 0.0 1.8e-18 67.9 0.0 2.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFX00060.1 - 2e-17 63.4 0.0 6.6e-17 61.7 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFX00060.1 - 4.8e-13 49.0 3.1 1.7e-12 47.2 0.0 3.5 4 0 0 4 4 4 1 short chain dehydrogenase PP-binding PF00550.25 EFX00060.1 - 3.2e-10 40.2 0.1 9.7e-10 38.7 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EFX00060.1 - 1.5e-07 31.2 0.1 1.5e-07 31.2 0.1 2.4 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EFX00060.1 - 1.8e-05 24.6 0.1 4.8e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ACP_syn_III PF08545.10 EFX00060.1 - 0.0003 20.6 0.4 0.004 17.0 0.2 2.9 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 EFX00060.1 - 0.0011 18.5 0.1 0.0049 16.3 0.1 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain SAT PF16073.5 EFX00060.1 - 0.037 13.8 0.5 0.18 11.5 0.3 2.0 2 1 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Polysacc_synt_2 PF02719.15 EFX00060.1 - 0.089 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RIFIN PF02009.16 EFX00061.1 - 0.49 10.2 1.4 0.62 9.9 1.4 1.0 1 0 0 1 1 1 0 Rifin TNFR_16_TM PF18422.1 EFX00062.1 - 0.21 11.6 0.3 0.42 10.6 0.3 1.5 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain Phage_min_cap2 PF06152.11 EFX00062.1 - 2.2 7.1 6.6 3.1 6.6 6.6 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 RIFIN PF02009.16 EFX00063.1 - 0.015 15.2 0.2 0.024 14.5 0.2 1.3 1 0 0 1 1 1 0 Rifin Apt1 PF10351.9 EFX00063.1 - 0.81 8.5 8.4 1 8.1 8.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 EFX00063.1 - 2.1 7.7 5.6 2.9 7.2 5.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Macoilin PF09726.9 EFX00063.1 - 6 5.3 12.2 8.7 4.8 12.2 1.2 1 0 0 1 1 1 0 Macoilin family FMN_dh PF01070.18 EFX00064.1 - 8.9e-118 393.3 0.0 1.1e-117 393.0 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EFX00064.1 - 8.9e-20 70.6 0.0 1.7e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EFX00064.1 - 3.9e-08 32.8 0.0 6.6e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EFX00064.1 - 0.00031 19.9 8.3 0.00064 18.8 1.5 3.0 2 2 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EFX00064.1 - 0.00044 19.6 0.1 1.1 8.5 0.0 2.7 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 EFX00064.1 - 0.0022 17.4 0.3 0.0022 17.4 0.3 1.4 2 0 0 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 EFX00064.1 - 0.0028 17.1 0.3 2 7.8 0.0 2.7 3 0 0 3 3 3 2 Histidine biosynthesis protein Dus PF01207.17 EFX00064.1 - 0.0047 16.1 0.1 0.022 13.9 0.0 2.0 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EFX00064.1 - 0.008 15.4 0.1 0.072 12.3 0.0 2.0 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase DUF5078 PF16877.5 EFX00064.1 - 0.054 14.0 0.1 0.1 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5078) APG17 PF04108.12 EFX00065.1 - 8.3e-131 436.7 0.1 1e-130 436.5 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 VIT1 PF01988.19 EFX00065.1 - 3.2e-63 213.5 0.6 1e-62 211.9 0.0 2.2 2 1 0 2 2 2 1 VIT family Herpes_UL36 PF03586.13 EFX00065.1 - 2 7.7 8.4 8.5 5.6 2.7 2.6 1 1 0 2 2 2 0 Herpesvirus UL36 tegument protein CENP-B_dimeris PF09026.10 EFX00065.1 - 8.2 6.9 19.6 0.22 11.9 0.2 3.3 3 1 1 4 4 4 0 Centromere protein B dimerisation domain DUF4451 PF14616.6 EFX00066.1 - 1.5e-15 57.5 0.0 1.5e-15 57.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4451) EF-hand_6 PF13405.6 EFX00067.1 - 3.6e-11 42.1 0.1 0.00016 21.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFX00067.1 - 1.1e-09 37.1 0.5 0.00021 20.6 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFX00067.1 - 1.3e-06 28.8 0.1 5.4e-06 26.8 0.1 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFX00067.1 - 2.5e-06 27.2 0.0 0.052 13.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFX00067.1 - 1.7e-05 24.1 1.7 0.07 12.7 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EFX00067.1 - 0.0012 19.1 0.0 0.88 9.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SOG2 PF10428.9 EFX00067.1 - 1.1 8.4 9.8 1.6 7.8 9.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Mgm101p PF06420.12 EFX00068.1 - 8.6e-85 282.5 0.0 1.1e-84 282.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Pkinase PF00069.25 EFX00069.1 - 3.8e-12 46.1 0.0 6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFX00069.1 - 1.7e-06 27.1 0.0 2.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase MFS_1 PF07690.16 EFX00070.1 - 2.3e-23 82.7 12.1 2.3e-23 82.7 12.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Viral_Beta_CD PF04530.12 EFX00070.1 - 0.015 15.6 0.8 0.032 14.5 0.1 1.9 2 0 0 2 2 2 0 Viral Beta C/D like family Herpes_US9 PF06072.11 EFX00070.1 - 0.19 11.6 3.4 5.4 7.0 0.2 3.0 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 PG_isomerase_N PF18353.1 EFX00071.1 - 0.39 11.1 4.9 0.25 11.7 3.5 1.5 1 1 1 2 2 2 0 Phosphoglucose isomerase N-terminal domain Thiolase_N PF00108.23 EFX00072.1 - 5.8e-64 215.9 0.9 9.5e-64 215.2 0.9 1.3 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFX00072.1 - 1.9e-41 140.5 0.3 4.1e-40 136.2 0.1 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFX00072.1 - 0.00034 20.3 3.0 0.00098 18.8 2.2 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Beta-lactamase2 PF13354.6 EFX00072.1 - 0.079 12.6 0.1 11 5.6 0.0 2.7 3 0 0 3 3 3 0 Beta-lactamase enzyme family ACP_syn_III PF08545.10 EFX00072.1 - 0.2 11.5 2.2 5.3 7.0 0.7 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III WW PF00397.26 EFX00073.1 - 1.8e-07 31.1 4.2 3.8e-07 30.1 4.2 1.5 1 0 0 1 1 1 1 WW domain WRW PF10206.9 EFX00073.1 - 0.021 15.2 0.1 0.04 14.3 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Zip PF02535.22 EFX00073.1 - 0.31 10.2 2.6 0.34 10.1 2.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 EFX00073.1 - 6.8 5.3 11.6 0.62 8.7 6.4 1.7 2 0 0 2 2 2 0 Raftlin 2OG-FeII_Oxy PF03171.20 EFX00074.1 - 0.002 18.6 0.1 0.0058 17.1 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFX00074.1 - 0.022 15.5 0.0 0.039 14.7 0.0 1.3 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal NAD_kinase PF01513.21 EFX00075.1 - 1.2e-51 175.6 0.1 8.1e-34 117.1 0.1 2.1 2 0 0 2 2 2 2 ATP-NAD kinase bZIP_2 PF07716.15 EFX00076.1 - 0.0025 17.8 12.4 0.0025 17.8 12.4 2.5 2 0 0 2 2 2 1 Basic region leucine zipper AAA_23 PF13476.6 EFX00076.1 - 2.6 8.5 8.3 3.8 8.0 8.3 1.2 1 0 0 1 1 1 0 AAA domain Roughex PF06020.11 EFX00076.1 - 4.8 6.2 7.1 8 5.5 7.1 1.3 1 0 0 1 1 1 0 Drosophila roughex protein TB2_DP1_HVA22 PF03134.19 EFX00077.1 - 4.7e-25 87.3 7.9 7e-25 86.8 7.9 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family RraA-like PF03737.15 EFX00078.1 - 9.8e-35 119.9 0.2 1.3e-34 119.6 0.2 1.1 1 0 0 1 1 1 1 Aldolase/RraA ICMT PF04140.14 EFX00079.1 - 3.8e-27 94.5 1.0 3.8e-27 94.5 1.0 1.8 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFX00079.1 - 2.1e-11 44.2 0.3 2.1e-11 44.2 0.3 2.3 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EFX00079.1 - 0.00042 19.9 0.5 0.00077 19.0 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) TauD PF02668.16 EFX00080.1 - 3.7e-21 76.1 0.3 2.7e-20 73.3 0.3 1.9 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family BPL_N PF09825.9 EFX00081.1 - 4.2e-121 404.6 0.0 7e-121 403.8 0.0 1.4 1 1 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EFX00081.1 - 5.3e-16 58.7 0.0 9.8e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family NUDE_C PF04880.13 EFX00082.1 - 1.8e-41 142.5 6.4 1.8e-41 142.5 6.4 4.4 2 1 2 4 4 4 1 NUDE protein, C-terminal conserved region ZapB PF06005.12 EFX00082.1 - 0.0052 17.2 6.9 0.0052 17.2 6.9 4.4 2 1 2 4 4 4 1 Cell division protein ZapB DUF745 PF05335.13 EFX00082.1 - 0.076 12.7 8.4 0.15 11.8 8.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Fez1 PF06818.15 EFX00082.1 - 0.077 13.4 23.0 2.4 8.6 22.7 2.7 2 1 0 2 2 2 0 Fez1 PSII_Pbs27 PF13326.6 EFX00082.1 - 0.41 10.9 3.8 1.2 9.5 3.8 1.7 1 0 0 1 1 1 0 Photosystem II Pbs27 Phage_GP20 PF06810.11 EFX00082.1 - 2.6 7.8 17.5 2.5 7.9 6.9 3.1 1 1 2 3 3 3 0 Phage minor structural protein GP20 FPP PF05911.11 EFX00082.1 - 7.4 4.6 24.8 14 3.7 21.9 2.1 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil Chibby PF14645.6 EFX00082.1 - 9 6.7 13.8 6.5 7.2 2.9 2.8 2 1 1 3 3 3 0 Chibby family Fmp27_WPPW PF10359.9 EFX00082.1 - 9.8 4.9 15.0 85 1.8 15.0 2.0 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Flavoprotein PF02441.19 EFX00084.1 - 1.8e-40 138.3 0.0 8e-39 132.9 0.0 2.1 1 1 0 1 1 1 1 Flavoprotein AAA_2 PF07724.14 EFX00085.1 - 3.6e-46 157.4 0.0 2.8e-45 154.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFX00085.1 - 2.6e-33 114.1 8.8 6.1e-33 112.9 1.6 3.5 3 1 1 4 4 3 1 AAA lid domain AAA PF00004.29 EFX00085.1 - 7e-25 88.0 0.0 1.7e-12 47.9 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFX00085.1 - 3.6e-24 84.6 1.9 5.2e-24 84.1 0.4 2.2 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFX00085.1 - 7.8e-13 48.6 0.4 1.8e-09 37.7 0.0 3.7 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFX00085.1 - 2.8e-09 37.4 0.7 5.5e-05 23.5 0.0 4.7 3 2 1 4 4 4 1 AAA domain Sigma54_activat PF00158.26 EFX00085.1 - 8.2e-07 28.9 0.0 9.9e-06 25.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 EFX00085.1 - 2.2e-06 28.2 5.8 0.0018 18.7 0.1 5.1 4 2 0 4 4 2 1 AAA ATPase domain Clp_N PF02861.20 EFX00085.1 - 2.8e-06 27.4 0.1 0.007 16.5 0.0 3.8 3 0 0 3 3 3 1 Clp amino terminal domain, pathogenicity island component AAA_14 PF13173.6 EFX00085.1 - 1.6e-05 24.9 0.0 0.41 10.7 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EFX00085.1 - 0.00014 22.4 0.0 0.71 10.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EFX00085.1 - 0.00046 20.4 0.0 0.25 11.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EFX00085.1 - 0.0005 19.9 0.0 0.76 9.6 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EFX00085.1 - 0.0008 18.5 0.0 0.0029 16.7 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 EFX00085.1 - 0.00099 18.7 0.0 0.0079 15.7 0.0 2.3 2 1 0 2 2 2 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFX00085.1 - 0.0024 17.3 0.9 0.2 11.0 0.0 3.2 3 1 1 4 4 4 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFX00085.1 - 0.0029 17.9 0.0 1.2 9.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFX00085.1 - 0.0045 17.3 0.0 0.56 10.6 0.0 2.6 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 EFX00085.1 - 0.0078 16.0 0.0 0.053 13.2 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein Torsin PF06309.11 EFX00085.1 - 0.0079 16.3 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 Torsin AAA_30 PF13604.6 EFX00085.1 - 0.012 15.3 0.0 1 9.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain Macoilin PF09726.9 EFX00085.1 - 0.023 13.3 5.3 0.035 12.7 5.3 1.2 1 0 0 1 1 1 0 Macoilin family ABC_tran PF00005.27 EFX00085.1 - 0.05 14.1 0.5 0.78 10.2 0.0 3.1 4 0 0 4 4 4 0 ABC transporter AAA_19 PF13245.6 EFX00085.1 - 0.051 13.9 0.0 42 4.5 0.0 3.6 3 1 0 3 3 3 0 AAA domain GAS PF13851.6 EFX00085.1 - 0.072 12.4 4.3 0.18 11.1 4.3 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TsaE PF02367.17 EFX00085.1 - 0.093 12.7 0.0 4.6 7.3 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EFX00085.1 - 0.12 12.3 0.0 1.9 8.5 0.0 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit V_ATPase_I PF01496.19 EFX00085.1 - 0.25 9.2 0.7 0.35 8.7 0.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.6 EFX00085.1 - 0.34 11.4 0.0 0.34 11.4 0.0 3.6 3 1 0 3 3 2 0 AAA domain CHDCT2 PF08074.11 EFX00085.1 - 0.42 10.8 3.3 1.1 9.4 0.2 2.9 2 1 1 3 3 3 0 CHDCT2 (NUC038) domain Cep57_CLD_2 PF14197.6 EFX00085.1 - 1.2 9.3 6.5 5 7.3 6.5 2.1 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Spc7 PF08317.11 EFX00085.1 - 2.1 7.1 7.3 4.2 6.2 7.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein ABC_tran PF00005.27 EFX00086.1 - 3.1e-46 157.3 0.0 9.7e-27 94.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFX00086.1 - 4.5e-38 131.5 36.5 2.7e-24 86.3 10.5 3.7 4 0 0 4 4 3 3 ABC transporter transmembrane region SMC_N PF02463.19 EFX00086.1 - 3.7e-11 42.9 3.1 2.4e-05 23.9 0.0 4.1 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EFX00086.1 - 8.9e-07 28.7 0.1 0.0014 18.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFX00086.1 - 1.3e-05 25.5 0.6 0.25 11.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFX00086.1 - 0.0001 22.7 0.1 0.62 10.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EFX00086.1 - 0.00011 22.1 0.5 5.5 6.7 0.0 4.4 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFX00086.1 - 0.00013 21.6 3.1 0.0062 16.3 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF2075 PF09848.9 EFX00086.1 - 0.00026 20.4 0.4 0.19 11.0 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EFX00086.1 - 0.0012 17.9 0.6 0.1 11.7 0.0 2.8 3 0 0 3 3 3 1 Type II/IV secretion system protein RNA_helicase PF00910.22 EFX00086.1 - 0.0022 18.3 0.0 0.43 11.0 0.0 2.6 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.23 EFX00086.1 - 0.0029 17.7 0.1 0.52 10.4 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFX00086.1 - 0.0029 17.5 0.5 3 7.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EFX00086.1 - 0.0035 17.9 1.8 2 8.9 0.3 2.3 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EFX00086.1 - 0.0038 17.2 0.8 2.9 7.8 0.0 2.6 2 0 0 2 2 2 2 NACHT domain cobW PF02492.19 EFX00086.1 - 0.0069 16.0 1.6 1.1 8.8 0.2 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EFX00086.1 - 0.008 15.7 0.2 1.5 8.3 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Dynamin_N PF00350.23 EFX00086.1 - 0.013 15.5 0.1 1.4 9.0 0.1 2.4 2 0 0 2 2 2 0 Dynamin family IstB_IS21 PF01695.17 EFX00086.1 - 0.017 14.9 0.4 3.9 7.2 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein ATPase_2 PF01637.18 EFX00086.1 - 0.02 14.8 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA PF00004.29 EFX00086.1 - 0.021 15.2 0.1 7.4 7.0 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EFX00086.1 - 0.029 13.7 2.0 0.18 11.1 0.0 2.5 3 0 0 3 3 3 0 KaiC Sigma54_activat PF00158.26 EFX00086.1 - 0.05 13.3 0.0 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain 2Fe-2S_thioredx PF01257.19 EFX00086.1 - 0.052 13.4 0.1 1.7 8.5 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin-like [2Fe-2S] ferredoxin AAA_11 PF13086.6 EFX00086.1 - 0.1 12.4 0.2 0.73 9.6 0.0 2.3 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 EFX00086.1 - 0.11 12.8 0.0 19 5.6 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PhoH PF02562.16 EFX00086.1 - 0.12 11.8 1.2 14 5.1 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein TIP49 PF06068.13 EFX00086.1 - 0.21 10.8 0.4 18 4.4 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_30 PF13604.6 EFX00086.1 - 0.21 11.3 3.8 1.6 8.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EFX00086.1 - 0.47 10.5 3.7 0.37 10.8 0.4 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain NB-ARC PF00931.22 EFX00086.1 - 1.6 7.9 4.3 12 5.0 0.3 2.6 2 1 0 2 2 2 0 NB-ARC domain ILVD_EDD PF00920.21 EFX00087.1 - 8.4e-212 704.4 0.0 1e-211 704.1 0.0 1.1 1 0 0 1 1 1 1 Dehydratase family WD40 PF00400.32 EFX00089.1 - 2.1e-58 192.9 13.4 4.4e-08 33.7 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EFX00089.1 - 6.6e-18 64.8 10.8 1.2e-17 63.9 10.8 1.5 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EFX00089.1 - 6.3e-16 58.5 0.0 0.0011 19.2 0.0 5.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX00089.1 - 1.3e-07 30.9 0.4 0.21 10.5 0.0 5.2 1 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFX00089.1 - 8.5e-07 28.6 0.0 0.05 12.9 0.0 4.6 3 1 2 5 5 5 2 WD40-like domain Nup160 PF11715.8 EFX00089.1 - 0.00052 18.8 0.1 1.6 7.3 0.0 3.2 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFX00089.1 - 0.011 14.3 0.7 0.13 10.7 0.3 2.5 1 1 1 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 EFX00089.1 - 0.016 15.2 0.0 9.7 6.3 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Golgin_A5 PF09787.9 EFX00089.1 - 0.025 14.0 3.3 0.037 13.5 3.3 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Nbas_N PF15492.6 EFX00089.1 - 0.045 13.1 0.1 22 4.3 0.0 3.0 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal GTP_EFTU PF00009.27 EFX00090.1 - 3e-42 144.4 0.4 5.6e-42 143.5 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFX00090.1 - 2.8e-29 101.7 0.0 7.6e-29 100.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFX00090.1 - 4.5e-08 33.4 2.8 8.7e-08 32.4 0.6 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFX00090.1 - 0.00033 20.7 0.1 0.0019 18.2 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Methyltransf_31 PF13847.6 EFX00091.1 - 9.8e-11 41.7 0.0 1.3e-09 38.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00091.1 - 2.7e-06 28.0 0.1 9.8e-06 26.2 0.1 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00091.1 - 1.8e-05 25.3 0.1 7e-05 23.4 0.1 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00091.1 - 3.9e-05 24.3 0.1 0.00028 21.5 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX00091.1 - 8.8e-05 22.4 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain HEAT PF02985.22 EFX00091.1 - 0.00042 20.3 9.9 0.68 10.3 0.1 6.7 7 0 0 7 7 7 1 HEAT repeat MetW PF07021.12 EFX00091.1 - 0.031 13.9 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW HEAT_2 PF13646.6 EFX00091.1 - 0.1 13.0 6.9 1.5 9.3 0.1 5.1 5 1 1 6 6 6 0 HEAT repeats Methyltransf_32 PF13679.6 EFX00091.1 - 0.16 11.9 0.0 0.56 10.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain HEAT_EZ PF13513.6 EFX00091.1 - 0.28 11.7 0.0 0.28 11.7 0.0 5.9 7 0 0 7 7 7 0 HEAT-like repeat Rtf2 PF04641.12 EFX00092.1 - 6.6e-43 147.0 0.1 8.9e-43 146.5 0.1 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.6 EFX00092.1 - 0.00029 21.1 0.1 0.00055 20.2 0.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFX00092.1 - 0.00049 20.0 0.0 0.00091 19.1 0.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFX00092.1 - 0.0022 17.8 0.2 0.0042 16.9 0.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX00092.1 - 0.012 15.5 0.6 0.031 14.1 0.1 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EFX00092.1 - 0.018 14.8 0.6 0.039 13.7 0.0 1.8 2 0 0 2 2 2 0 RING-like zinc finger SelP_N PF04592.14 EFX00092.1 - 0.025 14.0 1.5 0.038 13.4 1.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region zf-RING_UBOX PF13445.6 EFX00092.1 - 0.036 14.1 0.4 0.073 13.1 0.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.8 EFX00092.1 - 0.12 12.2 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit WRNPLPNID PF15017.6 EFX00092.1 - 0.31 12.0 2.2 0.46 11.4 0.1 2.3 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box DUF4407 PF14362.6 EFX00092.1 - 0.4 10.0 7.7 0.6 9.4 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TIP41 PF04176.13 EFX00093.1 - 6.4e-63 211.3 0.0 9.2e-63 210.8 0.0 1.2 1 0 0 1 1 1 1 TIP41-like family AA_permease PF00324.21 EFX00094.1 - 1.5e-127 426.1 39.8 1.9e-127 425.8 39.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX00094.1 - 8.2e-30 104.0 42.4 1.1e-29 103.5 42.4 1.1 1 0 0 1 1 1 1 Amino acid permease TPP_enzyme_N PF02776.18 EFX00095.1 - 2.9e-37 127.9 0.0 4e-36 124.2 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EFX00095.1 - 3.2e-19 69.2 0.0 7.5e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFX00095.1 - 1.5e-11 44.2 0.0 3.3e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Fungal_lectin PF07938.12 EFX00095.1 - 2.7e-08 33.6 0.5 0.0096 15.3 0.0 3.1 1 1 2 3 3 3 2 Fungal fucose-specific lectin Gal-bind_lectin PF00337.22 EFX00095.1 - 0.0088 15.6 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Galactoside-binding lectin DUF2183 PF09949.9 EFX00096.1 - 1.5e-31 108.7 0.0 2.6e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) SR-25 PF10500.9 EFX00096.1 - 3 7.4 5.5 4.7 6.8 5.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Abhydrolase_3 PF07859.13 EFX00097.1 - 5e-25 88.6 0.0 9.9e-25 87.6 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFX00097.1 - 3.8e-14 52.3 0.0 4.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EFX00097.1 - 0.0053 16.3 0.1 0.014 14.9 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Mito_carr PF00153.27 EFX00099.1 - 9.8e-15 54.3 4.2 4.5e-10 39.3 0.1 3.5 3 1 0 3 3 3 2 Mitochondrial carrier protein DUF4034 PF13226.6 EFX00099.1 - 0.069 12.5 1.6 0.13 11.6 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4034) MMS1_N PF10433.9 EFX00100.1 - 4e-156 520.5 0.0 1.3e-155 518.8 0.0 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFX00100.1 - 2.1e-94 316.5 0.0 9.7e-94 314.3 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region Thymidylate_kin PF02223.17 EFX00101.1 - 0.004 16.8 0.0 0.012 15.3 0.0 1.8 1 0 0 1 1 1 1 Thymidylate kinase DUF1962 PF09227.10 EFX00101.1 - 0.13 12.6 0.0 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1962) PUF PF00806.19 EFX00102.1 - 2e-28 96.4 0.0 0.00017 21.1 0.0 5.8 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EFX00102.1 - 5e-13 48.7 0.0 1.1e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 EFX00102.1 - 0.15 12.0 17.6 0.032 14.2 13.8 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.7 EFX00102.1 - 0.18 9.9 1.2 0.26 9.4 1.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 EFX00102.1 - 0.5 10.4 1.5 0.86 9.6 1.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Trypan_PARP PF05887.11 EFX00103.1 - 0.00018 21.5 23.2 0.00018 21.5 23.2 13.8 7 3 9 16 16 16 7 Procyclic acidic repetitive protein (PARP) Ysc84 PF04366.12 EFX00105.1 - 1.5e-49 166.9 0.1 2.8e-49 166.1 0.1 1.4 1 1 0 1 1 1 1 Las17-binding protein actin regulator Aldedh PF00171.22 EFX00106.1 - 1.8e-179 597.1 0.1 2.1e-179 596.9 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BAR PF03114.18 EFX00107.1 - 9.8e-65 218.5 4.9 1.2e-64 218.2 4.9 1.1 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 EFX00107.1 - 0.039 14.7 0.1 0.26 12.1 0.0 2.5 2 2 1 3 3 3 0 CP12 domain DUF2884 PF11101.8 EFX00107.1 - 0.082 12.4 3.3 3.5 7.1 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2884) DnaJ PF00226.31 EFX00107.1 - 0.43 10.7 3.7 2.4 8.4 1.1 2.9 2 1 1 3 3 3 0 DnaJ domain DUF5610 PF18433.1 EFX00107.1 - 0.85 10.1 4.1 0.82 10.2 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5610) BRE1 PF08647.11 EFX00107.1 - 1.2 9.3 6.2 4 7.6 1.7 2.7 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase SVIP PF15811.5 EFX00107.1 - 1.7 9.2 6.4 0.32 11.5 1.3 2.3 2 1 0 2 2 2 0 Small VCP/p97-interacting protein FliD_N PF02465.18 EFX00107.1 - 2.8 8.7 5.2 4.7 8.0 1.1 2.6 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus HisKA_3 PF07730.13 EFX00107.1 - 5.6 7.6 5.9 9.7 6.8 0.5 3.0 3 0 0 3 3 3 0 Histidine kinase Bac_luciferase PF00296.20 EFX00108.1 - 1.8e-55 188.6 9.0 2.7e-55 188.0 9.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase Whi5 PF08528.11 EFX00111.1 - 1.5e-10 40.4 0.1 2.6e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Whi5 like Aldedh PF00171.22 EFX00112.1 - 9.4e-134 446.4 0.0 3.7e-128 427.9 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 EFX00112.1 - 0.00056 19.4 0.0 0.0011 18.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) PNRC PF15365.6 EFX00113.1 - 7.2e-08 32.0 8.8 7.2e-08 32.0 8.8 4.3 5 0 0 5 5 5 1 Proline-rich nuclear receptor coactivator motif DUF3535 PF12054.8 EFX00115.1 - 3.5e-128 428.5 0.4 1.8e-126 422.9 0.3 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EFX00115.1 - 8.8e-66 222.0 0.0 2.5e-65 220.5 0.0 1.6 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX00115.1 - 2.6e-19 69.6 0.0 7.7e-19 68.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 EFX00115.1 - 3.4e-17 61.1 7.9 0.004 17.3 0.0 8.3 9 0 0 9 9 8 5 HEAT repeat HEAT_2 PF13646.6 EFX00115.1 - 1.2e-09 38.4 5.2 7e-05 23.1 0.0 6.6 8 0 0 8 8 7 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EFX00115.1 - 2.1e-08 34.7 0.2 0.2 12.3 0.0 4.2 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFX00115.1 - 3.2e-06 27.5 7.5 1.4 9.5 0.0 8.1 10 0 0 10 10 9 1 HEAT-like repeat CLASP_N PF12348.8 EFX00115.1 - 0.0017 18.0 0.0 1.1 8.7 0.0 2.9 2 0 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 EFX00115.1 - 0.0087 16.1 0.1 3.3 7.7 0.0 4.0 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.12 EFX00115.1 - 0.018 13.3 0.3 0.31 9.3 0.1 2.6 3 0 0 3 3 3 0 Down-regulated in metastasis ERCC3_RAD25_C PF16203.5 EFX00115.1 - 0.066 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UME PF08064.13 EFX00115.1 - 0.12 12.3 4.8 80 3.2 0.1 5.5 4 2 1 5 5 5 0 UME (NUC010) domain Iso_dh PF00180.20 EFX00116.1 - 7.8e-121 403.5 0.0 1e-120 403.1 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PHD PF00628.29 EFX00116.1 - 8.9e-08 31.9 3.8 1.4e-07 31.3 3.8 1.3 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFX00116.1 - 0.18 11.4 4.0 0.31 10.6 4.0 1.3 1 0 0 1 1 1 0 PHD-finger DUF745 PF05335.13 EFX00116.1 - 0.81 9.4 3.6 2 8.1 3.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Actin PF00022.19 EFX00117.1 - 2.6e-24 85.6 0.0 2.4e-14 52.8 0.0 3.1 2 1 0 2 2 2 2 Actin FtsA PF14450.6 EFX00117.1 - 0.00057 20.3 0.0 0.0076 16.7 0.0 2.5 2 1 0 2 2 2 1 Cell division protein FtsA Actin_micro PF17003.5 EFX00117.1 - 0.00098 18.4 0.5 0.15 11.3 0.1 2.5 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 EFX00117.1 - 0.0033 16.3 0.0 0.026 13.3 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Erf4 PF10256.9 EFX00119.1 - 8e-05 22.7 0.0 0.00081 19.5 0.0 2.2 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family LicD PF04991.13 EFX00119.1 - 0.0087 16.2 0.6 0.012 15.8 0.6 1.1 1 0 0 1 1 1 1 LicD family UBD PF16455.5 EFX00120.1 - 2e-34 117.9 4.2 2e-17 63.3 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin-binding domain SET PF00856.28 EFX00120.1 - 2.2e-16 60.7 0.3 1.8e-15 57.7 0.0 2.6 2 2 0 2 2 2 1 SET domain Pre-SET PF05033.16 EFX00120.1 - 7.7e-06 26.5 0.8 1.3e-05 25.8 0.8 1.3 1 0 0 1 1 1 1 Pre-SET motif ubiquitin PF00240.23 EFX00120.1 - 1.4e-05 24.8 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EFX00120.1 - 0.0018 18.8 0.1 0.006 17.1 0.1 1.9 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EFX00120.1 - 0.018 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RRN3 PF05327.11 EFX00120.1 - 4.2 5.8 6.1 6.2 5.2 6.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EFX00120.1 - 7.4 4.5 11.8 13 3.8 11.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi DCP1 PF06058.13 EFX00121.1 - 2.5e-22 79.0 0.0 4e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family Peptidase_C97 PF05903.14 EFX00122.1 - 0.00015 21.6 0.1 0.00024 20.9 0.1 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF778 PF05608.12 EFX00122.1 - 0.0023 18.3 0.0 0.0039 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF778) DUF4105 PF13387.6 EFX00122.1 - 0.034 13.8 0.0 0.05 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) LRAT PF04970.13 EFX00122.1 - 0.051 13.9 1.5 0.21 11.9 0.4 2.2 1 1 1 2 2 2 0 Lecithin retinol acyltransferase Pkinase PF00069.25 EFX00123.1 - 4.4e-57 193.4 0.0 7e-57 192.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00123.1 - 3.6e-20 72.3 0.0 6.4e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFX00123.1 - 7.7e-05 22.1 0.1 0.00014 21.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFX00123.1 - 8.8e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFX00123.1 - 0.00076 18.5 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFX00123.1 - 0.0028 17.6 1.2 0.012 15.6 1.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFX00123.1 - 0.0038 16.8 0.1 0.016 14.8 0.1 2.0 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 EFX00123.1 - 0.049 12.4 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase PAS_8 PF13188.7 EFX00123.1 - 0.088 12.9 0.0 28 4.9 0.0 2.8 2 0 0 2 2 2 0 PAS domain Ank_2 PF12796.7 EFX00124.1 - 9.1e-20 71.0 0.1 8.9e-13 48.6 0.1 2.7 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX00124.1 - 1.6e-11 44.5 0.1 0.00061 20.3 0.0 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX00124.1 - 7.3e-11 42.1 4.5 1.2e-05 25.5 0.2 4.3 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX00124.1 - 3.1e-10 39.4 0.7 0.0023 18.3 0.1 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EFX00124.1 - 2e-09 37.4 2.6 0.0018 18.7 0.5 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ribosomal_L14 PF00238.19 EFX00126.1 - 3.9e-46 156.1 4.0 4.5e-46 155.9 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e WD40 PF00400.32 EFX00127.1 - 3.7e-29 100.3 17.6 0.00029 21.6 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX00127.1 - 4.5e-11 42.9 0.0 2 8.8 0.0 6.0 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX00127.1 - 0.031 14.2 0.0 3.8 7.4 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EFX00127.1 - 0.18 10.5 0.0 1.1 7.9 0.0 2.0 2 0 0 2 2 2 0 Nup133 N terminal like MBOAT PF03062.19 EFX00128.1 - 1.4e-45 156.2 12.6 7.5e-45 153.8 12.6 2.2 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Arf PF00025.21 EFX00129.1 - 2.2e-65 219.4 0.0 2.5e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFX00129.1 - 1.5e-10 40.8 0.1 6.9e-07 28.7 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFX00129.1 - 1.2e-07 31.4 0.0 1.5e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFX00129.1 - 1.8e-07 31.4 0.0 6.3e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFX00129.1 - 3.4e-07 30.0 0.0 4.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFX00129.1 - 5.2e-07 29.7 0.0 7.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFX00129.1 - 2.3e-05 23.9 0.0 2.7e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFX00129.1 - 0.012 15.1 0.0 0.51 9.8 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EFX00129.1 - 0.17 11.4 0.0 8.9 5.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain tRNA_lig_CPD PF08302.11 EFX00132.1 - 3.2e-89 298.7 0.0 4.7e-89 298.2 0.0 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 EFX00132.1 - 4.6e-83 278.4 0.0 8.1e-83 277.6 0.0 1.4 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 EFX00132.1 - 1.6e-51 174.7 0.0 3.2e-51 173.7 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain SpecificRecomb PF10136.9 EFX00132.1 - 0.076 11.3 1.0 0.12 10.7 1.0 1.2 1 0 0 1 1 1 0 Site-specific recombinase AAA_18 PF13238.6 EFX00132.1 - 0.12 12.9 0.1 0.72 10.4 0.1 2.5 1 1 0 1 1 1 0 AAA domain DUF4023 PF13215.6 EFX00132.1 - 1.9 8.5 4.4 5.2 7.1 4.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) Rotamase PF00639.21 EFX00133.1 - 1.2e-22 80.6 0.2 3.1e-22 79.3 0.0 1.7 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EFX00133.1 - 3.6e-17 63.0 0.0 4.9e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EFX00133.1 - 3.5e-07 30.2 2.3 3.5e-07 30.2 2.3 1.7 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EFX00133.1 - 1.4e-05 25.9 0.1 3.2e-05 24.8 0.1 1.8 1 1 0 1 1 1 1 PPIC-type PPIASE domain MAM PF00629.23 EFX00133.1 - 0.0067 16.4 0.0 0.0089 16.0 0.0 1.3 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Amidase PF01425.21 EFX00134.1 - 4.4e-87 292.9 0.1 5.7e-86 289.3 0.1 1.9 1 1 0 1 1 1 1 Amidase RITA PF17066.5 EFX00135.1 - 0.014 15.0 0.8 0.026 14.1 0.8 1.5 1 1 0 1 1 1 0 RBPJ-interacting and tubulin associated protein PARP PF00644.20 EFX00136.1 - 7.4e-57 192.1 0.0 1e-56 191.6 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFX00136.1 - 1.2e-39 135.5 0.0 1.9e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFX00136.1 - 0.0094 16.0 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 WGR domain Pkinase PF00069.25 EFX00137.1 - 1.5e-55 188.4 0.0 2.2e-55 187.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00137.1 - 2.3e-34 118.8 0.0 3.7e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00137.1 - 1.1e-14 54.5 0.0 2.4e-11 43.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EFX00137.1 - 0.034 13.5 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF572 PF04502.13 EFX00137.1 - 0.16 11.5 0.6 0.25 10.9 0.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) NEAT PF05031.12 EFX00137.1 - 0.17 12.5 0.0 0.35 11.5 0.0 1.5 1 0 0 1 1 1 0 Iron Transport-associated domain Peptidase_M20 PF01546.28 EFX00138.1 - 5.3e-29 101.4 0.4 9.6e-29 100.6 0.4 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX00138.1 - 9.4e-07 28.7 0.1 2.1e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain DPM2 PF07297.12 EFX00139.1 - 5.4e-32 109.9 2.4 6.3e-32 109.7 2.4 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EFX00139.1 - 2e-05 24.5 0.9 2.2e-05 24.4 0.9 1.1 1 0 0 1 1 1 1 PIG-P DUF4229 PF14012.6 EFX00139.1 - 0.00096 19.2 4.0 0.0015 18.6 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) Phage_holin_3_6 PF07332.11 EFX00139.1 - 0.0057 16.7 1.0 0.0066 16.5 1.0 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III COX14 PF14880.6 EFX00139.1 - 0.0067 16.2 1.9 0.5 10.2 0.1 2.1 2 0 0 2 2 2 2 Cytochrome oxidase c assembly Cytochrom_C_asm PF01578.20 EFX00139.1 - 0.015 15.1 0.2 0.016 15.0 0.2 1.0 1 0 0 1 1 1 0 Cytochrome C assembly protein LapA_dom PF06305.11 EFX00139.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SPC12 PF06645.13 EFX00141.1 - 3.3e-29 100.8 0.2 4.2e-29 100.4 0.2 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) PTS_2-RNA PF01885.16 EFX00142.1 - 9.5e-55 185.4 0.0 1.2e-54 185.1 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Coiled PF05710.12 EFX00142.1 - 0.011 16.5 0.7 0.04 14.7 0.0 2.1 2 0 0 2 2 2 0 Coiled coil Sec15 PF04091.12 EFX00143.1 - 6.8e-113 377.2 4.8 6.8e-113 377.2 4.8 1.9 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like DUF2451 PF10474.9 EFX00143.1 - 6.5e-05 22.8 0.2 6.5e-05 22.8 0.2 2.5 2 1 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) DUF4201 PF13870.6 EFX00143.1 - 0.003 17.3 4.1 0.009 15.8 4.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF3510 PF12022.8 EFX00143.1 - 0.014 15.8 2.7 8 6.9 0.1 3.8 2 2 1 3 3 3 0 Domain of unknown function (DUF3510) COG5 PF10392.9 EFX00143.1 - 0.19 11.9 6.0 0.22 11.7 1.3 3.1 3 0 0 3 3 3 0 Golgi transport complex subunit 5 DAGK_prokar PF01219.19 EFX00143.1 - 0.43 10.4 1.4 22 4.9 0.0 3.0 3 0 0 3 3 3 0 Prokaryotic diacylglycerol kinase Seryl_tRNA_N PF02403.22 EFX00143.1 - 1.4 9.1 7.9 39 4.5 0.0 3.9 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Sec8_exocyst PF04048.14 EFX00143.1 - 1.6 8.6 10.7 0.18 11.7 2.9 3.3 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain AMP-binding PF00501.28 EFX00144.1 - 2.4e-65 220.8 0.2 3.3e-37 128.1 0.0 3.6 2 2 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EFX00144.1 - 2.9e-11 44.2 0.0 9e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.12 EFX00144.1 - 0.0016 18.4 0.3 0.0038 17.2 0.3 1.5 1 0 0 1 1 1 1 Gas vesicle protein G Transferase PF02458.15 EFX00145.1 - 3.9e-15 55.4 0.0 6e-14 51.5 0.0 2.7 1 1 0 1 1 1 1 Transferase family Phosducin PF02114.16 EFX00146.1 - 7.7e-11 41.4 0.1 9.7e-10 37.8 0.1 2.3 1 1 0 1 1 1 1 Phosducin Citrate_bind PF16114.5 EFX00146.1 - 0.082 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding HABP4_PAI-RBP1 PF04774.15 EFX00147.1 - 0.0059 17.4 11.3 0.027 15.3 11.3 2.1 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family Mhr1 PF12829.7 EFX00148.1 - 4.3e-34 116.4 0.0 6.3e-34 115.9 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination zinc_ribbon_16 PF17034.5 EFX00149.1 - 9.9e-18 64.6 7.2 1.9e-17 63.6 7.2 1.4 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EFX00149.1 - 2.7e-06 26.9 4.0 2.7e-06 26.9 4.0 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EFX00149.1 - 2.5 8.5 11.6 3.5 8.0 7.4 2.9 2 1 0 2 2 2 0 Ring finger domain Exo_endo_phos PF03372.23 EFX00150.1 - 1.1e-06 28.3 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 EFX00151.1 - 2.6e-58 192.6 38.8 2e-09 37.9 0.1 8.3 8 0 0 8 8 7 7 WD domain, G-beta repeat Ank_2 PF12796.7 EFX00151.1 - 2.1e-22 79.5 0.0 1.7e-09 38.1 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX00151.1 - 1.5e-19 70.1 0.3 2.6e-11 43.8 0.0 4.7 4 1 1 5 5 4 2 Ankyrin repeats (many copies) ANAPC4_WD40 PF12894.7 EFX00151.1 - 1.5e-19 70.0 4.6 0.00034 20.8 0.0 7.0 1 1 7 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ank_5 PF13857.6 EFX00151.1 - 5.1e-17 61.7 0.4 2.6e-09 37.1 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX00151.1 - 6.3e-16 56.9 0.1 0.00063 20.0 0.0 5.7 6 0 0 6 6 4 3 Ankyrin repeat Ank PF00023.30 EFX00151.1 - 1.3e-12 47.6 2.0 0.0018 18.7 0.0 5.9 6 0 0 6 6 6 2 Ankyrin repeat Nup160 PF11715.8 EFX00151.1 - 1.3e-10 40.6 7.2 0.068 11.8 0.0 5.8 1 1 3 5 5 5 3 Nucleoporin Nup120/160 NACHT PF05729.12 EFX00151.1 - 5.4e-08 32.9 0.0 1.2e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EFX00151.1 - 1.1e-05 24.6 9.5 0.46 9.4 1.1 5.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_22 PF13401.6 EFX00151.1 - 5.6e-05 23.4 0.0 0.00017 21.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX00151.1 - 7.4e-05 23.2 0.1 0.00049 20.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain KAP_NTPase PF07693.14 EFX00151.1 - 0.0012 18.1 0.1 0.2 10.9 0.0 2.3 1 1 1 2 2 2 1 KAP family P-loop domain PALB2_WD40 PF16756.5 EFX00151.1 - 0.0041 16.1 6.0 0.028 13.4 0.4 3.9 1 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 EFX00151.1 - 0.032 13.6 0.0 0.91 8.8 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 EFX00151.1 - 0.042 12.4 4.8 2.4 6.6 0.3 3.4 1 1 3 4 4 4 0 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 EFX00151.1 - 0.083 11.6 1.3 2.1 7.0 0.0 3.2 1 1 1 4 4 4 0 Nup133 N terminal like Nbas_N PF15492.6 EFX00151.1 - 0.11 11.8 2.6 8.1 5.7 0.0 3.9 1 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal AAA_29 PF13555.6 EFX00151.1 - 0.13 12.0 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain His_biosynth PF00977.21 EFX00152.1 - 2.1e-28 99.3 0.0 1.8e-27 96.3 0.0 1.9 1 1 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.17 EFX00152.1 - 0.075 12.5 0.1 0.18 11.3 0.1 1.6 1 0 0 1 1 1 0 PcrB family Ribul_P_3_epim PF00834.19 EFX00152.1 - 0.17 11.3 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Lactamase_B_4 PF13691.6 EFX00153.1 - 7.8e-27 92.8 0.1 2.8e-26 91.0 0.0 2.0 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EFX00153.1 - 6.4e-10 38.9 3.1 1.3e-09 37.8 1.6 2.4 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFX00153.1 - 8.1e-05 22.7 0.0 0.00033 20.7 0.0 2.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF1691 PF07950.11 EFX00153.1 - 0.032 15.0 0.0 0.1 13.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1691) PUL PF08324.11 EFX00154.1 - 1.5e-59 201.5 0.1 1.9e-59 201.2 0.1 1.1 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EFX00154.1 - 5.9e-35 120.3 0.0 9.8e-35 119.6 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EFX00154.1 - 1.5e-13 50.6 0.0 3.3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EFX00154.1 - 3.8e-06 26.9 0.1 6.5e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EFX00154.1 - 0.0034 17.8 0.2 0.028 14.9 0.2 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 EFX00154.1 - 0.0038 17.2 0.0 0.016 15.3 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin domain AhpC-TSA PF00578.21 EFX00154.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family OST3_OST6 PF04756.13 EFX00154.1 - 0.066 12.6 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Redoxin PF08534.10 EFX00154.1 - 0.068 12.9 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Redoxin T4_deiodinase PF00837.17 EFX00154.1 - 0.073 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Iodothyronine deiodinase DUF2847 PF11009.8 EFX00154.1 - 0.094 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) Thioredoxin_4 PF13462.6 EFX00154.1 - 0.19 11.9 0.0 0.46 10.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin EF-hand_1 PF00036.32 EFX00155.1 - 8.9e-23 78.1 3.4 6.5e-07 28.5 0.3 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFX00155.1 - 3.7e-19 68.3 5.8 1.2e-13 50.7 0.4 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFX00155.1 - 5.3e-18 63.3 1.9 1.1e-05 25.0 0.2 3.6 2 1 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EFX00155.1 - 1.3e-17 64.0 3.2 1.4e-11 44.6 0.1 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFX00155.1 - 2.3e-12 45.8 4.4 0.00012 21.4 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EFX00155.1 - 1.1e-10 41.6 0.0 4.6e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFX00155.1 - 9.4e-05 22.3 0.0 0.012 15.5 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EFX00155.1 - 0.00015 21.7 0.0 0.21 11.5 0.0 2.6 2 1 1 3 3 3 2 Caleosin related protein Dockerin_1 PF00404.18 EFX00155.1 - 0.084 13.1 0.0 16 5.7 0.0 2.2 2 0 0 2 2 2 0 Dockerin type I domain FAD_binding_3 PF01494.19 EFX00157.1 - 3e-57 194.4 0.0 3.7e-57 194.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EFX00157.1 - 9.6e-07 29.0 0.0 2.5e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EFX00157.1 - 2.2e-06 27.5 0.1 2.5e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX00157.1 - 0.00021 21.5 0.0 0.00068 19.8 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX00157.1 - 0.00038 19.8 0.1 0.011 15.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX00157.1 - 0.00057 19.2 0.0 0.0009 18.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX00157.1 - 0.00093 18.5 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EFX00157.1 - 0.0021 17.2 0.0 0.004 16.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EFX00157.1 - 0.0041 16.0 0.1 0.018 13.9 0.0 1.9 2 0 0 2 2 2 1 Tryptophan halogenase HI0933_like PF03486.14 EFX00157.1 - 0.0041 15.9 0.0 0.0062 15.3 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EFX00157.1 - 0.0045 17.5 0.1 0.011 16.3 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX00157.1 - 0.012 14.7 0.1 0.026 13.6 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 EFX00157.1 - 0.14 11.2 0.0 0.45 9.5 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_4 PF01565.23 EFX00158.1 - 1e-17 64.2 3.8 2.8e-17 62.8 3.8 1.8 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX00158.1 - 0.0032 17.6 0.6 0.01 15.9 0.6 2.0 1 0 0 1 1 1 1 Berberine and berberine like GARS_A PF01071.19 EFX00159.1 - 3.6e-73 245.5 0.0 5.9e-73 244.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EFX00159.1 - 1.4e-34 118.8 0.1 4.4e-34 117.1 0.1 1.9 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EFX00159.1 - 6.8e-34 117.3 0.0 1.7e-33 115.9 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EFX00159.1 - 1.2e-24 86.4 2.0 5.3e-24 84.3 0.3 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EFX00159.1 - 4.1e-14 53.0 1.8 4.1e-14 53.0 1.8 2.5 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain UDPGT PF00201.18 EFX00160.1 - 3.4e-10 39.3 0.0 6.3e-10 38.5 0.0 1.3 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Pex14_N PF04695.13 EFX00161.1 - 0.023 15.3 0.9 0.042 14.5 0.9 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cbl_N3 PF02762.14 EFX00161.1 - 0.045 13.6 0.2 0.085 12.7 0.2 1.4 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain CAP_N PF01213.19 EFX00161.1 - 3.6 7.0 6.3 5.8 6.3 6.3 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ank_2 PF12796.7 EFX00162.1 - 1.5e-53 179.3 0.9 8.4e-08 32.7 0.0 7.4 4 2 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX00162.1 - 1.5e-44 149.8 7.5 1.5e-05 25.5 0.1 13.0 5 4 10 15 15 15 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX00162.1 - 4.4e-34 112.7 9.1 0.0047 17.3 0.0 15.0 16 0 0 16 16 16 8 Ankyrin repeat Ank_5 PF13857.6 EFX00162.1 - 1.6e-30 104.7 14.4 9.5e-05 22.6 0.0 9.5 8 1 1 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EFX00162.1 - 4.9e-22 77.3 26.1 0.014 15.8 0.0 13.4 15 0 0 15 15 15 7 Ankyrin repeat Fcf2 PF08698.11 EFX00163.1 - 2.1e-30 105.0 0.1 2.1e-30 105.0 0.1 2.5 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing Endonuclease_NS PF01223.23 EFX00164.1 - 2.1e-63 214.1 0.0 2.5e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease PX PF00787.24 EFX00165.1 - 7.7e-18 64.5 0.0 2.3e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EFX00165.1 - 9.9e-12 44.9 9.8 3.5e-06 26.8 0.3 2.4 2 0 0 2 2 2 2 Vps5 C terminal like MFS_2 PF13347.6 EFX00165.1 - 1e-08 34.2 6.1 1e-08 34.2 6.1 2.3 3 0 0 3 3 3 1 MFS/sugar transport protein Pkinase PF00069.25 EFX00166.1 - 3.3e-69 233.2 0.0 4.3e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00166.1 - 3.6e-40 137.9 0.0 6.1e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00166.1 - 1.5e-05 24.5 0.0 0.00012 21.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFX00166.1 - 0.0012 18.2 0.1 0.0018 17.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFX00166.1 - 0.11 12.1 0.0 0.5 9.9 0.0 1.8 1 1 1 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.9 EFX00166.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TauD PF02668.16 EFX00167.1 - 4.8e-29 102.0 0.1 6.5e-29 101.6 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Anillin PF08174.11 EFX00168.1 - 3.6e-10 40.4 0.0 8.2e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 EFX00168.1 - 5.5e-08 33.3 0.0 2.1e-07 31.4 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFX00168.1 - 0.08 13.4 0.0 0.28 11.6 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain LRR_6 PF13516.6 EFX00169.1 - 1.9e-10 39.9 3.8 0.061 13.4 0.0 6.3 7 0 0 7 7 7 3 Leucine Rich repeat F-box-like PF12937.7 EFX00169.1 - 9.3e-10 38.3 0.0 3.3e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EFX00169.1 - 3.3e-07 30.5 7.2 0.17 12.4 0.0 6.5 5 2 2 7 7 7 2 Leucine Rich repeats (2 copies) F-box PF00646.33 EFX00169.1 - 4.7e-06 26.4 0.0 1.9e-05 24.4 0.0 2.1 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.33 EFX00169.1 - 6.2e-05 23.0 7.2 1.9 9.4 0.0 6.0 7 0 0 7 7 7 2 Leucine Rich Repeat PRANC PF09372.10 EFX00169.1 - 0.22 11.9 0.0 0.45 10.9 0.0 1.5 1 0 0 1 1 1 0 PRANC domain DUF2457 PF10446.9 EFX00172.1 - 6.5e-171 569.6 24.8 6.5e-171 569.6 24.8 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF2457) TFIIA PF03153.13 EFX00172.1 - 0.0032 17.5 18.6 0.0032 17.5 18.6 2.7 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DNA_pol_phi PF04931.13 EFX00172.1 - 1.8 6.5 33.3 2.8 5.9 33.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi zf-Tim10_DDP PF02953.15 EFX00173.1 - 2e-19 69.0 0.7 2.7e-19 68.6 0.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PS-DH PF14765.6 EFX00174.1 - 0.00073 18.9 0.2 0.00096 18.5 0.2 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase RRM_1 PF00076.22 EFX00176.1 - 5.6e-54 179.9 0.0 4.3e-19 68.1 0.1 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SDA1 PF05285.12 EFX00176.1 - 1.6e-06 27.8 33.3 1.6e-06 27.8 33.3 3.1 3 1 0 3 3 3 1 SDA1 BUD22 PF09073.10 EFX00176.1 - 1.9e-05 24.2 35.3 1.9e-05 24.2 35.3 3.3 3 1 0 3 3 3 1 BUD22 RRM_Rrp7 PF17799.1 EFX00176.1 - 4.4e-05 23.3 0.5 0.15 11.8 0.3 3.3 2 1 1 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 EFX00176.1 - 0.00088 19.3 0.0 16 5.7 0.0 3.7 3 0 0 3 3 3 1 RNA recognition motif Smg8_Smg9 PF10220.9 EFX00176.1 - 7.9 4.7 18.9 14 3.8 18.9 1.3 1 0 0 1 1 1 0 Smg8_Smg9 PX PF00787.24 EFX00177.1 - 5.4e-14 52.1 0.0 9e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 PX domain BCIP PF13862.6 EFX00177.1 - 0.01 15.6 0.1 0.016 15.0 0.1 1.3 1 0 0 1 1 1 0 p21-C-terminal region-binding protein DUF4203 PF13886.6 EFX00178.1 - 5.9e-54 182.8 28.4 8.5e-54 182.3 28.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Ysc84 PF04366.12 EFX00178.1 - 0.075 12.8 1.4 1.2 8.9 0.5 2.4 2 0 0 2 2 2 0 Las17-binding protein actin regulator DUF4512 PF14975.6 EFX00178.1 - 0.99 10.2 3.2 0.94 10.3 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Ribosomal_L13 PF00572.18 EFX00180.1 - 4.9e-12 46.2 0.0 4.6e-10 39.8 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 DSBA PF01323.20 EFX00180.1 - 0.063 13.1 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 DSBA-like thioredoxin domain Kinesin PF00225.23 EFX00181.1 - 5.2e-55 186.7 0.0 1.5e-53 181.9 0.0 2.4 1 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFX00181.1 - 1.2e-08 35.1 0.0 2e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 Microtubule binding DUF87 PF01935.17 EFX00181.1 - 0.14 12.2 0.1 7 6.7 0.4 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain TFIIA PF03153.13 EFX00181.1 - 4.9 7.0 10.7 0.55 10.2 4.3 2.2 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Peptidase_M20 PF01546.28 EFX00182.1 - 1.2e-24 87.2 0.0 2e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Ribonucleas_3_3 PF14622.6 EFX00182.1 - 7.9e-19 68.1 0.0 2.7e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 Ribonuclease-III-like M20_dimer PF07687.14 EFX00182.1 - 1.5e-06 28.1 0.0 2.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFX00182.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 EXS PF03124.14 EFX00183.1 - 1.5e-97 326.9 32.6 1.9e-97 326.6 32.6 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EFX00183.1 - 1e-84 285.7 1.3 2.2e-84 284.6 0.1 1.9 2 0 0 2 2 2 1 SPX domain Aldedh PF00171.22 EFX00184.1 - 9.2e-63 212.3 0.0 1.2e-62 211.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family HypD PF01924.16 EFX00184.1 - 0.18 10.8 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase formation hypA family Glycos_transf_3 PF00591.21 EFX00185.1 - 2.8e-59 200.7 0.0 5.9e-37 127.6 0.0 2.4 1 1 1 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EFX00185.1 - 1.6e-08 34.3 1.1 4e-08 33.0 1.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain CorA PF01544.18 EFX00186.1 - 2.1e-10 40.4 0.9 2.7e-10 40.0 0.9 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3584 PF12128.8 EFX00186.1 - 0.0022 15.6 1.9 0.0028 15.3 1.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Phasin PF05597.11 EFX00186.1 - 0.072 13.1 0.4 0.84 9.6 0.0 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) PhoU PF01895.19 EFX00186.1 - 0.074 13.5 1.2 0.23 11.9 1.2 1.9 1 1 0 1 1 1 0 PhoU domain Glycos_transf_2 PF00535.26 EFX00187.1 - 8.4e-36 123.3 0.0 9.9e-36 123.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFX00187.1 - 9.1e-12 45.4 0.0 1.3e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFX00187.1 - 6.3e-05 22.6 0.0 8.1e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFX00187.1 - 0.00052 19.5 0.0 0.00081 18.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Phageshock_PspD PF09584.10 EFX00187.1 - 0.14 12.2 0.1 0.33 11.0 0.1 1.7 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) Actin PF00022.19 EFX00188.1 - 1.7e-90 303.6 0.0 9.1e-90 301.2 0.0 1.8 1 1 0 1 1 1 1 Actin RRN3 PF05327.11 EFX00189.1 - 0.93 8.0 2.5 1.3 7.5 2.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Acetyltransf_1 PF00583.25 EFX00190.1 - 0.00021 21.5 0.2 0.00031 20.9 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX00190.1 - 0.00027 21.3 0.0 0.00044 20.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFX00190.1 - 0.0032 17.4 0.0 0.0053 16.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GCIP PF13324.6 EFX00191.1 - 1.4e-19 70.7 2.4 3.9e-19 69.3 0.7 2.4 2 1 0 2 2 2 1 Grap2 and cyclin-D-interacting Nbl1_Borealin_N PF10444.9 EFX00191.1 - 0.015 14.9 0.0 0.05 13.2 0.0 1.9 1 0 0 1 1 1 0 Nbl1 / Borealin N terminal CNDH2_C PF16858.5 EFX00191.1 - 0.035 14.0 0.3 0.051 13.4 0.3 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 EFX00191.1 - 0.042 12.1 1.5 0.056 11.7 1.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 EFX00191.1 - 0.2 10.8 12.4 0.3 10.2 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRN3 PF05327.11 EFX00191.1 - 0.6 8.6 8.2 1 7.8 8.2 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RXT2_N PF08595.11 EFX00191.1 - 1.4 9.0 4.1 2.7 8.0 4.1 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 EFX00191.1 - 2.6 6.0 11.7 3.5 5.6 11.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EFX00191.1 - 5.9 5.0 7.5 8.7 4.4 7.5 1.2 1 0 0 1 1 1 0 Nop14-like family Adenylsucc_synt PF00709.21 EFX00192.1 - 2.7e-158 527.3 0.0 3.1e-158 527.1 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Peptidase_C13 PF01650.18 EFX00194.1 - 0.022 14.3 0.1 0.048 13.2 0.1 1.5 1 0 0 1 1 1 0 Peptidase C13 family MFS_1 PF07690.16 EFX00195.1 - 5.9e-18 64.9 44.5 3.9e-09 35.9 12.0 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily ATG22 PF11700.8 EFX00195.1 - 1.6e-06 27.1 2.4 4e-06 25.8 0.0 2.5 2 1 1 3 3 3 2 Vacuole effluxer Atg22 like MFS_1_like PF12832.7 EFX00195.1 - 0.00017 20.6 0.0 0.018 13.9 0.0 3.1 3 1 0 3 3 3 1 MFS_1 like family LacY_symp PF01306.19 EFX00195.1 - 0.13 11.0 6.7 0.055 12.2 1.9 2.4 2 0 0 2 2 2 0 LacY proton/sugar symporter Sugar_tr PF00083.24 EFX00195.1 - 0.25 10.1 12.0 0.059 12.2 3.3 3.2 3 0 0 3 3 3 0 Sugar (and other) transporter Esterase PF00756.20 EFX00196.1 - 1e-52 179.3 0.1 1.2e-52 179.0 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EFX00196.1 - 0.00011 21.6 0.0 0.00016 21.0 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase_phd PF10503.9 EFX00196.1 - 0.0035 16.9 0.0 0.011 15.2 0.0 1.8 1 1 0 1 1 1 1 Esterase PHB depolymerase Chlorophyllase2 PF12740.7 EFX00196.1 - 0.0038 16.2 0.0 0.0056 15.6 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 EFX00196.1 - 0.0049 16.5 0.0 0.0082 15.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX00196.1 - 0.0078 15.7 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Ras PF00071.22 EFX00197.1 - 1.2e-17 63.9 0.2 5.1e-16 58.7 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFX00197.1 - 1.5e-13 51.0 0.7 3.2e-10 40.3 0.0 2.6 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX00197.1 - 0.015 14.8 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFX00197.1 - 0.022 14.1 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DLIC PF05783.11 EFX00197.1 - 0.048 12.5 0.1 0.14 10.9 0.0 1.7 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) CPBP PF02517.16 EFX00198.1 - 5.3e-17 62.0 8.4 5.3e-17 62.0 8.4 2.7 2 1 1 3 3 3 1 CPBP intramembrane metalloprotease UQ_con PF00179.26 EFX00199.1 - 1e-38 132.1 0.0 1.3e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EFX00199.1 - 6.5e-07 29.1 0.1 1.2e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EFX00199.1 - 0.001 18.8 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B DUF1421 PF07223.11 EFX00199.1 - 0.028 14.2 0.1 0.051 13.4 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain (DUF1421) UEV PF05743.13 EFX00199.1 - 0.05 13.5 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 UEV domain Peptidase_C12 PF01088.21 EFX00200.1 - 2.2e-12 47.2 0.0 2.5e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Isochorismatase PF00857.20 EFX00201.1 - 7.8e-28 97.8 1.8 1.1e-27 97.3 1.8 1.3 1 0 0 1 1 1 1 Isochorismatase family SSrecog PF03531.14 EFX00202.1 - 1.5e-31 108.1 0.3 1.7e-30 104.7 0.0 2.9 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 EFX00202.1 - 2.7e-31 107.9 1.6 1e-29 102.8 0.4 3.0 3 0 0 3 3 3 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 EFX00202.1 - 5.5e-25 87.6 0.0 1e-22 80.3 0.0 2.9 3 0 0 3 3 3 1 Histone chaperone Rttp106-like CDC45 PF02724.14 EFX00202.1 - 5.9 5.1 13.8 9.9 4.3 13.8 1.4 1 0 0 1 1 1 0 CDC45-like protein LOR PF04525.12 EFX00203.1 - 2.9e-22 79.2 0.0 3.4e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 LURP-one-related DUF3471 PF11954.8 EFX00203.1 - 0.09 13.2 0.0 0.2 12.1 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3471) Exo_endo_phos PF03372.23 EFX00204.1 - 1.3e-19 70.7 0.0 1.5e-18 67.2 0.0 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EFX00204.1 - 2.3e-10 40.1 7.1 1e-06 28.4 1.0 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFX00204.1 - 8e-07 29.3 4.1 0.0011 19.3 0.1 2.7 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) RseA_N PF03872.13 EFX00204.1 - 0.38 11.3 0.1 0.38 11.3 0.1 1.8 2 0 0 2 2 2 0 Anti sigma-E protein RseA, N-terminal domain Piwi PF02171.17 EFX00205.1 - 4e-52 177.3 0.1 3.7e-40 138.0 0.0 3.1 3 0 0 3 3 3 3 Piwi domain ArgoL2 PF16488.5 EFX00205.1 - 0.00043 20.6 0.0 0.0016 18.7 0.0 2.0 2 0 0 2 2 2 1 Argonaute linker 2 domain Glyoxalase_3 PF13468.6 EFX00207.1 - 2.7e-22 79.7 0.0 4.4e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain SSB PF00436.25 EFX00208.1 - 3.6e-17 62.3 0.0 4.4e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family MFS_1 PF07690.16 EFX00209.1 - 1.9e-37 129.0 51.7 5e-22 78.3 23.4 3.7 2 1 1 3 3 3 3 Major Facilitator Superfamily Methyltransf_23 PF13489.6 EFX00210.1 - 4.3e-06 26.6 0.1 0.0061 16.4 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain MFS_1 PF07690.16 EFX00211.1 - 1e-38 133.2 28.5 1e-38 133.2 28.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX00211.1 - 5.5e-06 25.1 4.2 8.5e-06 24.5 4.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Glyco_hydro_43 PF04616.14 EFX00212.1 - 5.1e-93 311.5 0.0 1.7e-92 309.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EFX00212.1 - 8.1e-35 120.4 0.0 3.1e-34 118.5 0.0 1.8 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain FAD_binding_2 PF00890.24 EFX00213.1 - 8.6e-93 311.7 4.7 1e-92 311.4 4.7 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFX00213.1 - 1.6e-08 34.6 0.3 6.1e-08 32.8 0.3 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EFX00213.1 - 7.8e-07 28.7 1.1 1.2e-06 28.0 0.2 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFX00213.1 - 2.5e-06 27.3 0.8 9.8e-06 25.4 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX00213.1 - 4.6e-06 26.1 0.5 7.9e-05 22.0 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX00213.1 - 7e-05 22.1 0.2 7e-05 22.1 0.2 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFX00213.1 - 0.00012 21.6 0.9 0.0002 20.9 0.9 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFX00213.1 - 0.00013 21.3 0.0 0.00037 19.8 0.0 1.8 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EFX00213.1 - 0.0023 16.7 0.4 0.0023 16.7 0.4 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EFX00213.1 - 0.014 15.9 0.6 0.035 14.6 0.6 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX00213.1 - 0.016 14.5 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX00213.1 - 0.049 12.9 0.6 0.11 11.7 0.2 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EFX00213.1 - 0.066 12.3 0.7 0.12 11.4 0.7 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EFX00213.1 - 0.7 9.2 3.5 0.41 9.9 0.2 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Exo70 PF03081.15 EFX00214.1 - 0.00072 18.7 3.2 0.25 10.3 0.2 2.4 1 1 0 2 2 2 2 Exo70 exocyst complex subunit DUF4449 PF14613.6 EFX00214.1 - 0.0026 17.9 1.8 0.015 15.4 0.0 3.1 3 2 0 3 3 3 1 Protein of unknown function (DUF4449) LBP_BPI_CETP PF01273.25 EFX00214.1 - 0.0051 16.4 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain SesA PF17107.5 EFX00214.1 - 0.019 15.2 0.4 0.77 10.0 0.1 2.8 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RB_A PF01858.17 EFX00214.1 - 0.023 14.5 1.7 1.3 8.8 0.0 2.7 2 1 0 2 2 2 0 Retinoblastoma-associated protein A domain EF-hand_3 PF09069.11 EFX00214.1 - 0.028 14.8 0.3 0.34 11.3 0.0 2.8 2 1 1 3 3 3 0 EF-hand DUF4763 PF15960.5 EFX00214.1 - 0.029 13.7 1.7 0.038 13.3 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) HMW1C_N PF18071.1 EFX00214.1 - 0.061 13.1 0.9 6.3 6.6 0.1 3.2 3 0 0 3 3 3 0 HMW1C N-terminal Mod_r PF07200.13 EFX00214.1 - 2.3 8.3 0.0 2.3 8.3 0.0 3.4 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein MRP-S31 PF15433.6 EFX00214.1 - 2.4 7.8 4.6 4.4 6.9 4.6 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF5344 PF17279.2 EFX00214.1 - 4.1 8.0 5.6 7.7 7.2 0.9 3.6 2 2 2 4 4 4 0 Family of unknown function (DUF5344) Cnd3 PF12719.7 EFX00217.1 - 1.9e-90 303.0 0.1 8.1e-90 301.0 0.0 2.1 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EFX00217.1 - 2e-08 34.5 19.3 1.2e-05 25.6 3.2 5.5 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EFX00217.1 - 0.0017 18.5 17.4 0.21 11.9 0.0 6.7 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 EFX00217.1 - 0.0022 18.1 5.2 0.56 10.2 0.0 4.2 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 EFX00217.1 - 0.1 11.9 0.4 0.91 8.7 0.0 2.7 4 0 0 4 4 4 0 V-ATPase subunit H HEAT_EZ PF13513.6 EFX00217.1 - 1.3 9.6 14.2 0.29 11.7 0.4 6.1 6 1 0 6 6 6 0 HEAT-like repeat Dsh_C PF12316.8 EFX00219.1 - 5 7.5 19.4 9.3 6.6 10.5 2.4 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal LrgB PF04172.16 EFX00220.1 - 5.1e-56 189.6 6.8 7.4e-56 189.1 6.8 1.2 1 0 0 1 1 1 1 LrgB-like family DUF1614 PF07758.11 EFX00220.1 - 0.017 15.1 0.7 0.017 15.1 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1614) AAA_32 PF13654.6 EFX00222.1 - 0.027 13.3 0.5 0.044 12.6 0.5 1.4 1 0 0 1 1 1 0 AAA domain DUF3181 PF11378.8 EFX00222.1 - 0.084 13.2 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) Porphobil_deam PF01379.20 EFX00223.1 - 4.3e-69 232.1 0.0 5.8e-69 231.7 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EFX00223.1 - 7.1e-20 71.2 0.6 1.3e-19 70.4 0.6 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain ACP_syn_III PF08545.10 EFX00223.1 - 0.14 12.0 0.1 3 7.8 0.0 2.3 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ORC3_N PF07034.11 EFX00224.1 - 0.17 11.0 0.8 0.26 10.4 0.8 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Clr5 PF14420.6 EFX00225.1 - 2.2e-14 53.4 0.8 3.7e-14 52.7 0.8 1.4 1 0 0 1 1 1 1 Clr5 domain MMM1 PF10296.9 EFX00226.1 - 3.7e-138 460.1 0.0 1.2e-136 455.2 0.0 2.1 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 MUG113 PF13455.6 EFX00227.1 - 2.3e-24 85.8 0.1 3.3e-24 85.3 0.1 1.2 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EFX00227.1 - 3e-23 82.3 0.0 5.3e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 T5orf172 domain TPR_2 PF07719.17 EFX00228.1 - 6e-23 79.1 27.0 0.012 15.6 0.1 12.0 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFX00228.1 - 2.2e-20 71.6 23.0 0.00084 19.1 0.1 11.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFX00228.1 - 5.5e-16 57.4 24.9 0.013 15.7 0.1 10.7 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 EFX00228.1 - 7.4e-12 45.6 21.2 0.02 15.4 0.1 10.1 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFX00228.1 - 3.3e-10 39.2 15.8 0.0017 18.2 0.0 9.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX00228.1 - 1.2e-09 38.4 27.8 0.025 14.8 0.0 9.8 9 2 1 10 10 10 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFX00228.1 - 2.3e-08 34.1 25.7 0.076 13.7 0.0 11.1 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFX00228.1 - 1.5e-06 28.5 23.9 0.52 11.3 0.0 12.0 12 1 1 13 13 12 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00228.1 - 6.2e-06 26.8 22.2 0.012 16.2 0.1 8.3 7 1 1 9 9 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX00228.1 - 4e-05 23.3 13.1 4.1 7.4 0.1 8.6 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFX00228.1 - 0.00034 20.2 19.7 3 7.6 0.1 7.6 8 0 0 8 8 8 3 TPR repeat TPR_17 PF13431.6 EFX00228.1 - 0.037 14.4 14.1 1.6 9.3 0.1 8.0 9 0 0 9 9 9 0 Tetratricopeptide repeat DUF2207 PF09972.9 EFX00229.1 - 0.044 12.5 0.0 0.065 12.0 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Apolipoprotein PF01442.18 EFX00230.1 - 0.0032 17.4 2.1 2.5 7.9 0.0 4.1 3 1 0 3 3 3 1 Apolipoprotein A1/A4/E domain Dynamin_N PF00350.23 EFX00230.1 - 0.041 13.9 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Dynamin family PI3K_P85_iSH2 PF16454.5 EFX00230.1 - 0.18 11.4 4.7 2.6 7.6 0.9 2.6 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RasGAP_C PF03836.15 EFX00230.1 - 0.24 11.6 5.5 5 7.3 0.4 3.1 2 1 1 3 3 3 0 RasGAP C-terminus DUF4140 PF13600.6 EFX00230.1 - 0.48 10.9 8.8 1.4 9.4 0.7 4.2 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Lebercilin PF15619.6 EFX00230.1 - 0.5 10.0 8.3 0.16 11.6 4.6 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.12 EFX00230.1 - 0.51 10.4 3.9 1.8 8.7 3.9 1.9 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 EFX00230.1 - 0.53 9.6 7.6 0.29 10.4 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FTA4 PF13093.6 EFX00230.1 - 1.2 9.0 3.6 18 5.1 2.8 2.6 1 1 1 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Mto2_bdg PF12808.7 EFX00230.1 - 2.9 8.3 5.1 1.3 9.4 0.2 2.8 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region THOC7 PF05615.13 EFX00230.1 - 3.1 8.1 5.8 5.6 7.3 1.7 2.8 1 1 0 2 2 2 0 Tho complex subunit 7 RNase_P_pop3 PF08228.11 EFX00231.1 - 1.5e-05 25.1 0.0 2.6e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 RNase P subunit Pop3 TANGO2 PF05742.12 EFX00232.1 - 1e-65 222.3 0.0 1.2e-65 222.1 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Methyltransf_23 PF13489.6 EFX00233.1 - 2.1e-20 73.2 0.0 4.3e-20 72.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00233.1 - 5.7e-12 46.2 0.0 1.2e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00233.1 - 3e-10 40.6 0.0 5.9e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00233.1 - 1.2e-07 32.3 0.0 5.8e-07 30.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00233.1 - 4.1e-07 29.9 0.0 3.4e-06 26.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX00233.1 - 0.00054 19.4 0.0 0.0068 15.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EFX00233.1 - 0.0037 16.6 0.0 0.0086 15.4 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 EFX00233.1 - 0.034 13.7 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DNA_pol_phi PF04931.13 EFX00233.1 - 5.7 4.9 7.5 7.9 4.4 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Fungal_trans PF04082.18 EFX00234.1 - 1.8e-09 37.1 0.0 1.8e-09 37.1 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX00234.1 - 5.1e-06 26.5 15.5 1e-05 25.6 15.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EPL1 PF10513.9 EFX00234.1 - 0.29 11.5 11.6 0.44 10.9 6.3 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Tim54 PF11711.8 EFX00234.1 - 0.78 8.5 12.1 1.5 7.5 8.6 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 EFX00234.1 - 4 6.6 7.4 7.1 5.7 7.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 EFX00234.1 - 4.4 7.2 25.9 0.23 11.4 13.5 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PAT1 PF09770.9 EFX00234.1 - 5.5 5.1 34.4 0.21 9.8 18.9 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.13 EFX00234.1 - 8.8 7.0 41.3 8.8 7.0 22.2 2.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TCP PF03634.13 EFX00234.1 - 9.2 6.8 12.3 4.1 8.0 7.4 2.2 2 0 0 2 2 2 0 TCP family transcription factor SET PF00856.28 EFX00235.1 - 7.4e-10 39.5 0.0 1.9e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 EFX00235.1 - 2.1 8.5 9.2 0.12 12.4 2.1 2.8 2 1 0 2 2 2 0 MYND finger Colipase-like PF15083.6 EFX00236.1 - 0.071 13.2 9.0 1.5 9.0 1.7 2.3 2 0 0 2 2 2 0 Colipase-like VitD-bind_III PF09164.10 EFX00236.1 - 0.11 12.5 7.8 0.47 10.5 1.1 2.5 2 0 0 2 2 2 0 Vitamin D binding protein, domain III Calpain_inhib PF00748.19 EFX00236.1 - 8.4 6.9 8.2 2.5 8.6 1.3 2.2 2 0 0 2 2 2 0 Calpain inhibitor zf-MYND PF01753.18 EFX00237.1 - 4.5e-05 23.5 13.8 0.0001 22.3 13.8 1.7 1 0 0 1 1 1 1 MYND finger PXA PF02194.15 EFX00238.1 - 4.9e-40 137.4 0.5 7e-40 136.9 0.5 1.2 1 0 0 1 1 1 1 PXA domain MARVEL PF01284.23 EFX00238.1 - 0.031 14.3 0.5 1 9.4 0.3 2.6 2 0 0 2 2 2 0 Membrane-associating domain PalH PF08733.10 EFX00239.1 - 1e-119 399.4 0.0 1.2e-119 399.2 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 CAAD PF14159.6 EFX00239.1 - 0.2 11.5 0.4 0.54 10.1 0.4 1.7 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Lipase_GDSL_2 PF13472.6 EFX00241.1 - 1.2e-19 71.4 0.0 2.8e-19 70.2 0.0 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFX00241.1 - 6.9e-13 49.0 0.0 1.2e-12 48.3 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Acetyltransf_7 PF13508.7 EFX00242.1 - 1.1e-06 29.0 0.1 1.5e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX00242.1 - 1.5e-05 25.2 0.5 3.3e-05 24.1 0.5 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX00242.1 - 0.00019 21.4 0.0 0.00043 20.2 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX00242.1 - 0.00075 19.4 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EFX00242.1 - 0.003 17.2 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFX00242.1 - 0.07 13.8 0.0 0.52 11.0 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Zip PF02535.22 EFX00244.1 - 3e-26 92.4 8.5 1.2e-25 90.5 8.5 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Phage_holin_3_1 PF05106.12 EFX00244.1 - 0.56 10.7 3.5 0.25 11.8 0.2 2.1 3 0 0 3 3 3 0 Phage holin family (Lysis protein S) Xpo1 PF08389.12 EFX00245.1 - 6.1e-37 127.0 0.5 9.2e-36 123.1 0.0 3.1 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 EFX00245.1 - 0.00087 19.3 0.1 23 5.6 0.0 5.0 4 0 0 4 4 4 2 HEAT repeat Sec7_N PF12783.7 EFX00245.1 - 0.059 13.3 1.9 1.4 8.8 0.0 3.5 4 0 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Secretin_N_2 PF07655.13 EFX00245.1 - 0.11 13.1 2.4 0.84 10.2 0.8 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain TetR_C_11 PF16859.5 EFX00245.1 - 0.14 12.4 7.0 0.25 11.7 0.0 4.9 7 1 1 8 8 8 0 Tetracyclin repressor-like, C-terminal domain UDPGT PF00201.18 EFX00246.1 - 8.8e-06 24.8 0.0 1.1e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DEAD PF00270.29 EFX00247.1 - 1.2e-39 135.9 0.7 1.8e-39 135.3 0.7 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX00247.1 - 1.6e-29 102.4 0.4 4.4e-29 101.1 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX00247.1 - 7.3e-07 29.3 0.0 1.6e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DPM3 PF08285.11 EFX00248.1 - 6.9e-32 109.5 0.1 7.6e-32 109.4 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CFEM PF05730.11 EFX00250.1 - 4.9e-11 42.5 10.5 4.9e-11 42.5 10.5 2.3 2 1 0 2 2 2 1 CFEM domain CDC27 PF09507.10 EFX00250.1 - 1.4 8.2 9.5 1.7 8.0 9.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PRKCSH_1 PF13015.6 EFX00251.1 - 1.1e-27 96.6 1.2 1.1e-27 96.6 1.2 1.9 3 0 0 3 3 2 1 Glucosidase II beta subunit-like protein PRKCSH-like PF12999.7 EFX00251.1 - 3.5e-26 92.1 0.5 8.3e-26 90.8 0.0 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH PF07915.13 EFX00251.1 - 1.7e-10 41.7 0.8 5.9e-10 40.0 0.8 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EFX00251.1 - 0.0027 17.6 1.5 0.0054 16.6 1.5 1.5 1 0 0 1 1 1 1 Autophagy-related protein 27 Mod_r PF07200.13 EFX00251.1 - 0.0036 17.4 13.0 0.024 14.8 0.2 3.1 3 0 0 3 3 3 1 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.12 EFX00251.1 - 0.025 15.0 1.3 0.14 12.6 0.2 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein BNR_6 PF15899.5 EFX00251.1 - 0.038 14.1 0.2 0.15 12.2 0.2 2.0 1 0 0 1 1 1 0 BNR-Asp box repeat DUF4200 PF13863.6 EFX00251.1 - 0.047 14.1 19.0 0.71 10.3 8.8 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Nsp1_C PF05064.13 EFX00251.1 - 0.081 12.7 1.3 7.8 6.3 0.3 2.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region EzrA PF06160.12 EFX00251.1 - 0.11 10.7 7.9 0.017 13.3 3.0 1.8 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Prefoldin PF02996.17 EFX00251.1 - 0.13 12.2 0.3 0.13 12.2 0.3 3.0 3 1 0 3 3 3 0 Prefoldin subunit GTPase_binding PF09027.10 EFX00251.1 - 0.14 12.1 0.1 12 5.9 0.0 2.4 2 0 0 2 2 2 0 GTPase binding Snapin_Pallidin PF14712.6 EFX00251.1 - 0.2 12.1 3.5 1.3 9.5 0.1 2.5 2 0 0 2 2 2 0 Snapin/Pallidin DUF948 PF06103.11 EFX00251.1 - 0.21 11.8 1.6 9.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4472 PF14739.6 EFX00251.1 - 0.24 12.1 13.1 2.3 9.0 7.5 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) BLOC1_2 PF10046.9 EFX00251.1 - 0.25 11.6 5.7 4.1 7.8 0.4 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.18 EFX00251.1 - 0.94 9.8 6.6 8.9 6.7 2.0 3.0 2 0 0 2 2 2 0 TSC-22/dip/bun family APG6_N PF17675.1 EFX00251.1 - 1 9.9 17.0 16 6.0 7.9 3.4 3 0 0 3 3 3 0 Apg6 coiled-coil region PspA_IM30 PF04012.12 EFX00251.1 - 1.6 8.3 17.8 1.6 8.3 8.9 3.2 3 0 0 3 3 3 0 PspA/IM30 family TPR_MLP1_2 PF07926.12 EFX00251.1 - 1.6 8.8 20.9 9.2 6.3 10.1 3.4 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 EFX00251.1 - 1.6 8.8 7.8 3.5 7.7 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EFX00251.1 - 1.6 8.9 8.2 1.9 8.6 0.1 2.8 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EFX00251.1 - 2.1 7.6 17.1 0.053 12.9 7.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Lectin_N PF03954.14 EFX00251.1 - 2.6 7.8 7.1 16 5.3 0.7 3.0 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Prefoldin_2 PF01920.20 EFX00251.1 - 2.6 8.0 15.7 2.7 8.0 3.8 3.5 3 1 0 3 3 3 0 Prefoldin subunit Exonuc_VII_L PF02601.15 EFX00251.1 - 3.4 7.2 6.7 7.7 6.0 4.1 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Spc24 PF08286.11 EFX00251.1 - 3.7 7.8 12.9 9.6 6.5 1.0 3.3 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 UPF0242 PF06785.11 EFX00251.1 - 5.2 7.1 12.0 3.1 7.8 7.5 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 EFX00251.1 - 5.8 6.1 12.8 3.3 7.0 4.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) PEARLI-4 PF05278.12 EFX00251.1 - 6.5 6.3 11.9 1.6 8.2 8.3 1.8 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) TMF_DNA_bd PF12329.8 EFX00251.1 - 6.9 6.7 20.7 4 7.5 2.0 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF1465 PF07323.12 EFX00251.1 - 7 6.5 9.9 3.3 7.5 1.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1465) XhlA PF10779.9 EFX00251.1 - 7.5 6.8 8.9 12 6.2 1.7 2.6 2 0 0 2 2 2 0 Haemolysin XhlA ApbA_C PF08546.11 EFX00252.1 - 3.2e-33 114.6 0.0 5.6e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFX00252.1 - 6.2e-21 74.6 0.0 9.9e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Afi1 PF07792.12 EFX00253.1 - 1.8e-48 164.4 12.2 8.2e-48 162.2 12.2 2.0 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EFX00253.1 - 5.2e-35 119.8 0.0 1e-34 118.9 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EFX00253.1 - 5.9e-06 25.2 0.1 0.069 11.8 0.0 3.9 3 1 1 4 4 4 2 Transport protein Avl9 TFIIA PF03153.13 EFX00253.1 - 0.0046 17.0 17.7 0.011 15.8 17.7 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 EFX00253.1 - 0.12 12.1 20.6 0.22 11.2 20.6 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2347 PF09804.9 EFX00253.1 - 0.21 11.2 0.0 0.94 9.0 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) SDA1 PF05285.12 EFX00253.1 - 2 7.8 16.2 3.2 7.1 16.2 1.2 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 EFX00253.1 - 3.6 6.3 9.8 6.1 5.5 9.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.12 EFX00253.1 - 7.7 4.6 18.0 12 3.9 18.0 1.2 1 0 0 1 1 1 0 Nop14-like family ABC2_membrane PF01061.24 EFX00255.1 - 5.9e-91 303.6 54.3 2.9e-46 157.6 25.6 2.8 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 EFX00255.1 - 3e-37 126.4 6.1 1.5e-31 108.1 0.0 3.4 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.27 EFX00255.1 - 5.8e-35 120.8 0.0 1.9e-16 60.8 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.6 EFX00255.1 - 6.1e-17 62.0 0.1 2.2e-16 60.2 0.1 2.1 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EFX00255.1 - 7e-08 33.0 0.2 0.00066 20.1 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFX00255.1 - 6.2e-07 29.5 0.0 0.00047 20.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 EFX00255.1 - 5.3e-06 26.1 0.1 0.00043 19.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFX00255.1 - 3.7e-05 23.9 0.1 0.015 15.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFX00255.1 - 0.00011 22.8 0.0 0.016 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFX00255.1 - 0.00017 21.3 1.0 0.055 13.1 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 EFX00255.1 - 0.00055 19.8 0.1 0.87 9.3 0.0 2.7 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFX00255.1 - 0.0015 18.8 0.1 1.3 9.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFX00255.1 - 0.0027 17.5 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFX00255.1 - 0.0031 17.2 0.6 0.065 13.0 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.6 EFX00255.1 - 0.0059 17.0 0.1 0.69 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFX00255.1 - 0.006 17.0 0.0 1.4 9.4 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC2_membrane_3 PF12698.7 EFX00255.1 - 0.0091 15.1 39.1 0.075 12.1 13.8 3.2 2 2 1 3 3 3 2 ABC-2 family transporter protein NACHT PF05729.12 EFX00255.1 - 0.021 14.8 0.6 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 EFX00255.1 - 0.036 14.3 0.1 5.6 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFX00255.1 - 0.042 13.6 0.1 5.1 6.8 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_24 PF13479.6 EFX00255.1 - 0.17 11.6 0.9 18 4.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF3246 PF11596.8 EFX00255.1 - 0.29 10.5 3.7 0.54 9.7 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) AAA_19 PF13245.6 EFX00255.1 - 0.69 10.2 2.3 2.7 8.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain Fasciclin PF02469.22 EFX00256.1 - 1.1e-21 77.4 1.7 2.9e-17 63.1 0.5 3.1 2 1 0 2 2 2 2 Fasciclin domain Flocculin_t3 PF13928.6 EFX00257.1 - 0.0013 19.2 60.6 0.0062 17.0 25.5 13.5 2 2 7 9 9 9 4 Flocculin type 3 repeat QVR PF17064.5 EFX00257.1 - 0.019 15.2 3.1 9 6.6 0.1 3.4 1 1 2 3 3 3 0 Sleepless protein Swi5 PF07061.11 EFX00258.1 - 6.2e-15 55.0 0.1 9.6e-15 54.4 0.1 1.4 1 0 0 1 1 1 1 Swi5 p450 PF00067.22 EFX00260.1 - 1.6e-84 284.3 0.0 1.9e-84 284.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PLAC8 PF04749.17 EFX00261.1 - 1.5e-22 80.5 11.4 1.8e-22 80.1 11.4 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4246 PF14033.6 EFX00262.1 - 3.6e-163 543.9 0.0 5.8e-163 543.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) Rrp15p PF07890.12 EFX00262.1 - 1.4e-37 129.0 8.0 1.4e-37 129.0 8.0 1.7 2 0 0 2 2 2 1 Rrp15p Ammonium_transp PF00909.21 EFX00263.1 - 1.7e-118 395.8 26.9 2e-118 395.6 26.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family CLP_protease PF00574.23 EFX00264.1 - 5.3e-22 78.6 0.4 1.7e-13 50.8 0.0 2.8 2 1 1 3 3 3 2 Clp protease TPR_12 PF13424.6 EFX00266.1 - 3.8e-17 62.4 6.3 1.6e-07 31.5 0.1 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00266.1 - 1.6e-08 34.0 3.0 0.0059 16.6 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX00266.1 - 2.1e-07 30.4 0.0 0.01 15.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX00266.1 - 4e-05 23.3 7.6 0.55 10.2 0.3 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFX00266.1 - 5.3e-05 22.9 1.7 1.1 9.5 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat NB-ARC PF00931.22 EFX00266.1 - 0.0036 16.5 0.0 0.0072 15.5 0.0 1.5 1 1 0 1 1 1 1 NB-ARC domain TPR_16 PF13432.6 EFX00266.1 - 0.0074 16.9 6.7 1.4 9.7 0.1 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.6 EFX00266.1 - 0.039 14.3 0.1 0.16 12.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain ATPase PF06745.13 EFX00266.1 - 0.27 10.6 0.0 0.44 9.8 0.0 1.2 1 0 0 1 1 1 0 KaiC TPR_14 PF13428.6 EFX00266.1 - 2.7 9.1 9.8 42 5.3 0.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Ribosomal_L10 PF00466.20 EFX00267.1 - 0.063 13.4 0.0 3.3 7.9 0.0 2.4 2 1 0 2 2 2 0 Ribosomal protein L10 OPT PF03169.15 EFX00268.1 - 1.6e-174 582.0 52.7 1.8e-174 581.8 52.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Sec1 PF00995.23 EFX00270.1 - 4.7e-124 415.7 0.0 5.7e-124 415.5 0.0 1.1 1 0 0 1 1 1 1 Sec1 family CDP-OH_P_transf PF01066.21 EFX00270.1 - 5.6e-12 46.3 0.9 1.8e-11 44.6 0.9 2.0 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DNA_pol_A_exoN PF18305.1 EFX00270.1 - 0.027 14.8 0.1 11 6.4 0.0 3.2 3 0 0 3 3 3 0 3' to 5' exonuclease C-terminal domain BEX PF04538.12 EFX00270.1 - 0.029 15.0 0.1 0.061 13.9 0.1 1.5 1 0 0 1 1 1 0 Brain expressed X-linked like family Glyco_hydro_39 PF01229.17 EFX00271.1 - 1.2e-05 24.2 0.0 1.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Bim_N PF06773.11 EFX00272.1 - 0.63 9.8 2.8 1.5 8.6 0.1 2.5 2 0 0 2 2 2 0 Bim protein N-terminus Ribosomal_S13 PF00416.22 EFX00275.1 - 1.7e-53 180.4 2.0 2e-53 180.2 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 zf-C3HC4_3 PF13920.6 EFX00276.1 - 0.54 10.2 7.9 1.9 8.4 4.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Serglycin PF04360.12 EFX00276.1 - 3.6 7.5 13.2 0.7 9.8 6.4 2.5 2 0 0 2 2 2 0 Serglycin PNP_phzG_C PF10590.9 EFX00277.1 - 5.8e-12 45.5 3.8 8.2e-12 45.0 3.8 1.2 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region AAA PF00004.29 EFX00278.1 - 3.8e-18 66.2 0.0 6.5e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX00278.1 - 0.0024 18.3 0.0 0.0053 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EFX00278.1 - 0.014 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFX00278.1 - 0.034 14.4 0.6 0.14 12.4 0.1 2.0 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 EFX00278.1 - 0.066 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFX00278.1 - 0.088 13.0 0.0 0.28 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFX00278.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.13 EFX00278.1 - 0.15 11.2 0.1 0.31 10.2 0.1 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain LAT PF15234.6 EFX00278.1 - 0.33 10.6 2.0 0.61 9.8 0.4 1.9 2 0 0 2 2 2 0 Linker for activation of T-cells CdvA PF18822.1 EFX00279.1 - 0.0039 17.0 0.2 0.0073 16.1 0.2 1.3 1 0 0 1 1 1 1 CdvA-like coiled-coil domain KH_8 PF17903.1 EFX00280.1 - 2.9e-06 27.3 0.0 5.7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EFX00280.1 - 0.00067 19.4 0.9 0.0015 18.3 0.9 1.6 1 0 0 1 1 1 1 KH domain SAM_2 PF07647.17 EFX00281.1 - 4.2e-17 62.0 0.0 7.6e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFX00281.1 - 7.4e-15 55.1 0.0 1.4e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EFX00281.1 - 6e-12 46.0 0.0 2e-10 41.1 0.0 2.5 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 EFX00281.1 - 0.024 14.6 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) GFA PF04828.14 EFX00282.1 - 4.9e-07 30.0 4.9 0.00077 19.7 0.2 2.8 2 1 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DUF2321 PF10083.9 EFX00282.1 - 0.022 14.4 3.6 1.9 8.1 0.0 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Nudix_N_2 PF14803.6 EFX00282.1 - 0.031 14.2 7.0 0.053 13.4 0.0 3.3 3 0 0 3 3 3 0 Nudix N-terminal NOB1_Zn_bind PF08772.11 EFX00282.1 - 0.94 9.7 4.4 15 5.8 1.7 2.9 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-C3HC4 PF00097.25 EFX00282.1 - 4.4 7.2 9.6 9.7 6.2 0.1 3.6 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 EFX00282.1 - 7.9 6.6 11.1 10 6.2 2.1 3.6 3 1 0 3 3 3 0 Double zinc ribbon MMR_HSR1 PF01926.23 EFX00284.1 - 0.00082 19.4 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFX00284.1 - 0.058 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 AIG1 family RsgA_GTPase PF03193.16 EFX00284.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase DUF3150 PF11348.8 EFX00284.1 - 0.12 11.6 0.5 4.8 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3150) fn3 PF00041.21 EFX00284.1 - 0.14 12.5 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type III domain Cwf_Cwc_15 PF04889.12 EFX00284.1 - 7.2 6.3 8.1 14 5.3 8.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AOX PF01786.17 EFX00285.1 - 6.1e-89 297.3 0.0 9.1e-89 296.7 0.0 1.3 1 0 0 1 1 1 1 Alternative oxidase O-FucT PF10250.9 EFX00285.1 - 9.2e-06 25.6 0.0 2.2e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Ran-binding PF05508.11 EFX00287.1 - 2.2e-95 319.3 0.0 2.9e-95 318.9 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein PINIT PF14324.6 EFX00288.1 - 3.3e-45 154.0 0.0 5.8e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EFX00288.1 - 1.5e-22 79.1 3.8 2.4e-22 78.4 3.8 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EFX00288.1 - 2.2e-07 30.6 0.7 4.3e-07 29.7 0.7 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EFX00288.1 - 8.8e-07 28.5 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 SAP domain zf-C3HC4_4 PF15227.6 EFX00288.1 - 0.028 14.6 2.9 0.052 13.7 2.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFX00288.1 - 0.36 10.8 1.4 0.75 9.8 1.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFX00288.1 - 0.44 10.4 3.5 0.94 9.4 3.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Histone PF00125.24 EFX00289.1 - 1.2e-40 138.9 0.0 1.5e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFX00289.1 - 0.00076 19.6 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFX00289.1 - 0.0017 18.7 0.0 0.0023 18.3 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFX00289.1 - 0.033 14.5 0.0 0.048 14.0 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PDEase_I PF00233.19 EFX00291.1 - 3.1e-63 213.7 0.0 4.8e-63 213.1 0.0 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase MMR_HSR1_Xtn PF16897.5 EFX00292.1 - 2.7e-41 139.9 0.4 3.2e-40 136.4 0.2 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EFX00292.1 - 6e-24 83.9 0.1 1.1e-23 83.0 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EFX00292.1 - 1.3e-20 73.5 0.0 7.4e-20 71.1 0.0 2.1 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX00292.1 - 7.8e-09 35.3 0.1 4.1e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFX00292.1 - 0.00079 19.5 0.1 0.1 12.7 0.0 2.4 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EFX00292.1 - 0.0013 18.3 0.2 4 6.9 0.0 3.8 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFX00292.1 - 0.04 12.9 0.2 0.14 11.1 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFX00292.1 - 0.15 12.6 0.0 0.32 11.5 0.0 1.7 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EFX00292.1 - 0.17 11.8 2.8 9.9 6.0 0.0 3.1 4 0 0 4 4 4 0 RsgA GTPase Pkinase PF00069.25 EFX00293.1 - 1.7e-50 171.9 0.0 1.2e-49 169.1 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00293.1 - 1e-19 70.8 0.0 1.3e-18 67.2 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00293.1 - 0.12 11.7 0.6 3 7.1 0.1 2.4 2 0 0 2 2 2 0 Kinase-like Pkinase PF00069.25 EFX00294.1 - 3.8e-51 174.0 0.0 7.1e-51 173.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00294.1 - 1.5e-29 103.0 0.0 2.3e-29 102.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00294.1 - 3.2e-06 26.7 0.0 2.8e-05 23.6 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFX00294.1 - 0.00064 19.1 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFX00294.1 - 0.013 14.3 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EFX00294.1 - 0.014 15.3 0.0 0.035 14.0 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EFX00294.1 - 0.018 14.7 0.0 0.062 12.9 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Sugar_tr PF00083.24 EFX00295.1 - 6.5e-27 94.5 18.3 1.3e-23 83.7 6.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFX00295.1 - 2.5e-08 33.3 26.1 4.5e-06 25.8 10.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CBM_21 PF03370.13 EFX00296.1 - 1.2e-31 109.2 0.0 2.3e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EFX00296.1 - 1e-09 38.8 0.1 2.7e-09 37.5 0.1 1.7 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) ATP_transf PF09830.9 EFX00297.1 - 5.2e-24 84.2 0.0 8.7e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4922 PF16269.5 EFX00297.1 - 0.005 16.6 0.0 0.019 14.7 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4922) DprA_WH PF17782.1 EFX00297.1 - 0.11 12.6 0.6 11 6.2 0.0 3.1 3 0 0 3 3 3 0 DprA winged helix domain Methyltransf_23 PF13489.6 EFX00298.1 - 4.2e-14 52.7 0.0 9.1e-14 51.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00298.1 - 3e-08 34.3 0.0 1.8e-07 31.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00298.1 - 2.3e-05 25.0 0.0 6.8e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00298.1 - 3.2e-05 23.8 0.0 0.0045 16.8 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00298.1 - 0.00021 22.0 0.0 0.0029 18.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EFX00298.1 - 0.001 19.2 0.0 0.0036 17.4 0.0 1.8 3 0 0 3 3 3 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EFX00298.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 EFX00298.1 - 0.014 15.0 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 EFX00298.1 - 0.034 13.5 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EFX00298.1 - 0.039 13.4 0.0 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_16 PF10294.9 EFX00298.1 - 0.056 13.2 0.0 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Lysine methyltransferase Ubie_methyltran PF01209.18 EFX00298.1 - 0.096 12.0 0.0 1.2 8.4 0.0 2.2 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family tRNA-synt_1c PF00749.21 EFX00299.1 - 2.8e-103 345.1 0.1 3.6e-103 344.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFX00299.1 - 2.4e-36 125.2 0.0 3.8e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain MA3 PF02847.17 EFX00300.1 - 1.8e-20 73.0 0.0 5e-20 71.6 0.0 1.8 2 0 0 2 2 2 1 MA3 domain Serglycin PF04360.12 EFX00300.1 - 0.036 14.0 0.8 0.036 14.0 0.8 2.0 3 0 0 3 3 3 0 Serglycin ADH_N PF08240.12 EFX00301.1 - 3.1e-30 104.3 1.0 5.2e-30 103.5 1.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX00301.1 - 3.5e-14 52.9 0.0 5.5e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EFX00301.1 - 0.00044 20.1 0.0 0.0012 18.7 0.0 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Glu_dehyd_C PF16912.5 EFX00301.1 - 0.00067 19.2 0.1 0.0012 18.3 0.1 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EFX00301.1 - 0.022 14.0 0.2 0.04 13.2 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Vac_ImportDeg PF09783.9 EFX00302.1 - 1.3e-68 229.8 2.1 1.7e-68 229.5 2.1 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein AAA PF00004.29 EFX00303.1 - 5.6e-19 68.9 0.0 9.6e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX00303.1 - 0.0001 22.3 0.0 0.00026 21.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zot PF05707.12 EFX00303.1 - 0.00028 20.6 0.0 0.0056 16.3 0.0 2.4 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_16 PF13191.6 EFX00303.1 - 0.00035 21.0 0.0 0.00097 19.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EFX00303.1 - 0.0014 18.8 0.0 0.0029 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFX00303.1 - 0.0036 17.6 0.1 0.019 15.2 0.0 2.2 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 EFX00303.1 - 0.013 14.9 0.4 0.048 13.0 0.1 2.0 2 1 0 2 2 2 0 KaiC IstB_IS21 PF01695.17 EFX00303.1 - 0.029 14.1 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EFX00303.1 - 0.043 13.8 0.0 0.091 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFX00303.1 - 0.049 14.2 0.0 0.12 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFX00303.1 - 0.064 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EFX00303.1 - 0.085 12.6 0.0 0.25 11.1 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 EFX00303.1 - 0.16 11.9 0.0 0.82 9.5 0.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EFX00303.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EFX00303.1 - 0.19 11.2 0.1 0.5 9.8 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Biotin_lipoyl PF00364.22 EFX00304.1 - 1.6e-20 72.7 0.1 2.8e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EFX00304.1 - 1.1e-09 38.4 0.1 3.5e-09 36.9 0.1 1.9 1 0 0 1 1 1 1 e3 binding domain TPR_14 PF13428.6 EFX00304.1 - 9.5e-06 26.0 20.1 0.1 13.5 1.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00304.1 - 2.8e-05 23.9 12.2 0.052 13.7 0.3 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX00304.1 - 0.00016 21.6 2.1 0.052 13.8 0.1 3.6 3 0 0 3 3 2 1 Tetratricopeptide repeat Biotin_lipoyl_2 PF13533.6 EFX00304.1 - 0.00026 20.8 0.0 0.00078 19.2 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like TPR_17 PF13431.6 EFX00304.1 - 0.0019 18.4 3.0 0.033 14.5 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFX00304.1 - 0.0029 18.1 15.1 0.017 15.6 0.5 5.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00304.1 - 0.016 15.9 12.9 0.47 11.1 0.1 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFX00304.1 - 0.035 13.9 7.0 0.43 10.5 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFX00304.1 - 0.049 13.9 9.9 0.24 11.7 0.4 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFX00304.1 - 0.26 12.0 4.9 9 7.2 0.1 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFX00304.1 - 1.4 9.2 3.3 53 4.2 0.2 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX00304.1 - 3.6 7.9 4.9 18 5.7 0.2 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Glucosamine_iso PF01182.20 EFX00309.1 - 1.9e-63 214.3 0.0 4.8e-63 213.1 0.0 1.6 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Methyltransf_2 PF00891.18 EFX00311.1 - 5.5e-13 48.7 0.1 8.3e-13 48.1 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase domain CheR PF01739.18 EFX00311.1 - 0.049 13.1 0.2 0.073 12.6 0.2 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Peptidase_C14 PF00656.22 EFX00312.1 - 1.4e-47 162.7 0.0 2.3e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Med22 PF06179.12 EFX00312.1 - 4.4e-15 55.8 0.0 8.3e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex TRAM_LAG1_CLN8 PF03798.16 EFX00313.1 - 4.3e-35 121.3 18.1 4.3e-35 121.3 18.1 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EFX00313.1 - 7e-26 89.7 0.1 1.9e-25 88.3 0.1 1.8 1 0 0 1 1 1 1 TRAM1-like protein dCMP_cyt_deam_1 PF00383.23 EFX00314.1 - 5.9e-08 32.5 0.0 8.7e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFX00314.1 - 6.8e-07 29.1 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase FAD_binding_4 PF01565.23 EFX00315.1 - 2.3e-20 72.7 4.2 5.1e-20 71.6 4.2 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX00315.1 - 3.6e-08 33.4 0.3 7.2e-08 32.4 0.3 1.5 1 0 0 1 1 1 1 Berberine and berberine like WD40 PF00400.32 EFX00316.1 - 6.5e-29 99.6 13.8 2.8e-06 28.0 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EFX00316.1 - 3.3e-09 36.5 0.2 6.5e-09 35.5 0.2 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EFX00316.1 - 9.4e-07 29.0 0.1 0.033 14.5 0.0 4.6 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EFX00316.1 - 2e-06 27.5 0.1 4.4e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EFX00316.1 - 0.00019 20.3 0.3 0.41 9.2 0.1 3.2 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Activator_LAG-3 PF11498.8 EFX00316.1 - 4 6.3 16.1 8.6 5.2 16.1 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Egh16-like PF11327.8 EFX00317.1 - 1.4e-51 175.5 8.9 1.4e-51 175.5 8.9 1.6 2 0 0 2 2 2 1 Egh16-like virulence factor Izumo-Ig PF16706.5 EFX00317.1 - 0.033 14.3 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain FAT PF02259.23 EFX00319.1 - 7.2e-120 400.3 2.2 2.8e-74 250.4 6.0 2.7 2 0 0 2 2 2 2 FAT domain DUF3385 PF11865.8 EFX00319.1 - 4.7e-72 241.2 6.0 2.1e-67 226.0 0.7 5.1 3 1 1 4 4 4 2 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.27 EFX00319.1 - 1.5e-69 234.6 0.1 2.6e-69 233.8 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 EFX00319.1 - 1.4e-44 150.5 1.1 5.5e-44 148.6 0.1 2.7 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain HEAT PF02985.22 EFX00319.1 - 2.6e-11 42.8 15.7 0.00093 19.3 0.0 10.7 11 0 0 11 11 11 2 HEAT repeat HEAT_2 PF13646.6 EFX00319.1 - 7.9e-09 35.8 12.7 0.022 15.1 0.0 8.7 7 2 3 10 10 10 1 HEAT repeats FATC PF02260.20 EFX00319.1 - 1.1e-07 31.5 0.1 3.3e-07 30.0 0.1 1.9 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.6 EFX00319.1 - 4.8e-05 23.8 14.1 0.0086 16.6 0.0 8.4 7 1 1 8 8 6 2 HEAT-like repeat Adaptin_N PF01602.20 EFX00319.1 - 6.5e-05 21.7 7.3 6.1 5.3 0.0 5.7 5 2 1 6 6 6 4 Adaptin N terminal region Cnd1 PF12717.7 EFX00319.1 - 0.0052 16.8 8.0 0.25 11.4 0.0 5.7 4 1 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EFX00319.1 - 0.018 14.8 0.8 2.9 7.6 0.0 3.6 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Collagen PF01391.18 EFX00319.1 - 0.057 13.2 5.7 0.16 11.7 5.7 1.7 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) FANCI_S2 PF14676.6 EFX00319.1 - 0.28 11.5 5.0 3.3 8.0 0.1 4.8 5 0 0 5 5 5 0 FANCI solenoid 2 Tti2 PF10521.9 EFX00319.1 - 0.28 10.7 4.0 4.8 6.6 0.9 3.5 3 0 0 3 3 3 0 Tti2 family DUF1772 PF08592.11 EFX00320.1 - 5.1e-05 23.6 10.5 0.0012 19.1 10.5 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) RNA_polI_A34 PF08208.11 EFX00320.1 - 0.19 11.8 0.0 0.27 11.3 0.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3328 PF11807.8 EFX00321.1 - 4.9e-47 160.5 0.0 5.9e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) COG2 PF06148.11 EFX00322.1 - 3.2e-21 75.8 0.5 8.7e-21 74.4 0.5 1.7 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 EFX00322.1 - 0.00038 20.7 0.0 0.00067 19.8 0.0 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Vps51 PF08700.11 EFX00322.1 - 0.0011 19.0 0.2 0.0039 17.3 0.1 2.1 1 1 1 2 2 2 1 Vps51/Vps67 Spc7 PF08317.11 EFX00322.1 - 0.02 13.8 0.1 0.029 13.2 0.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Dor1 PF04124.12 EFX00322.1 - 0.024 13.3 0.3 0.04 12.6 0.3 1.3 1 0 0 1 1 1 0 Dor1-like family Zn_clus PF00172.18 EFX00323.1 - 1e-08 35.1 9.7 1.8e-08 34.4 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFX00323.1 - 2.2e-08 33.3 0.1 3.4e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain NMT1 PF09084.11 EFX00324.1 - 1.9e-05 24.7 0.0 9.5e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 NMT1/THI5 like SBP_bac_3 PF00497.20 EFX00324.1 - 0.00046 19.7 0.0 0.0014 18.1 0.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Phosphonate-bd PF12974.7 EFX00324.1 - 0.00075 19.2 0.0 0.0011 18.7 0.0 1.3 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF3834 PF12916.7 EFX00324.1 - 0.055 12.7 0.0 0.73 9.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) Mito_carr PF00153.27 EFX00327.1 - 4.6e-14 52.1 5.0 0.00037 20.3 0.1 4.8 3 2 0 3 3 3 3 Mitochondrial carrier protein GIDA PF01134.22 EFX00328.1 - 6.6e-149 496.3 0.0 8.4e-149 495.9 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Tyr-DNA_phospho PF06087.12 EFX00328.1 - 6.1e-95 318.6 0.0 7.5e-95 318.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase GIDA_assoc PF13932.6 EFX00328.1 - 5.7e-43 147.5 0.0 1.2e-42 146.5 0.0 1.5 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 EFX00328.1 - 3.8e-06 26.5 1.7 6.5e-06 25.8 1.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX00328.1 - 0.00025 20.4 1.2 0.00029 20.2 0.3 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX00328.1 - 0.0022 17.2 3.2 0.0022 17.2 3.2 1.9 2 0 0 2 2 2 1 FAD binding domain PLDc_2 PF13091.6 EFX00328.1 - 0.025 14.5 0.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 PLD-like domain HI0933_like PF03486.14 EFX00328.1 - 0.051 12.3 1.2 0.26 10.0 0.8 2.0 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EFX00328.1 - 2.5 7.3 8.1 0.15 11.3 0.9 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PAP_assoc PF03828.19 EFX00330.1 - 1.7e-14 53.8 0.1 3.6e-14 52.7 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFX00330.1 - 2.3e-07 31.0 0.0 4.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain SHE3 PF17078.5 EFX00331.1 - 0.0062 16.3 0.4 0.011 15.4 0.4 1.4 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Synaptobrevin PF00957.21 EFX00331.1 - 0.018 14.8 0.6 0.036 13.9 0.6 1.4 1 0 0 1 1 1 0 Synaptobrevin Serglycin PF04360.12 EFX00331.1 - 0.018 15.0 2.7 0.038 13.9 2.7 1.5 1 0 0 1 1 1 0 Serglycin CAF1A PF12253.8 EFX00331.1 - 9.8 6.4 13.2 0.99 9.6 1.8 2.5 1 1 1 2 2 2 0 Chromatin assembly factor 1 subunit A His_Phos_1 PF00300.22 EFX00333.1 - 5.8e-19 68.5 0.3 2.1e-09 37.3 0.1 3.2 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) PDEase_II PF02112.15 EFX00334.1 - 8.2e-54 183.0 0.0 8.9e-23 80.9 0.0 3.1 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II HET PF06985.11 EFX00335.1 - 7.8e-14 52.2 0.2 3e-12 47.1 0.1 2.2 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) CALM_bind PF16025.5 EFX00335.1 - 0.074 13.5 0.5 1.1 9.8 0.3 2.4 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding ABC_tran PF00005.27 EFX00337.1 - 1.3e-27 96.9 0.0 1.9e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EFX00337.1 - 2.3e-24 86.0 28.9 4.2e-24 85.2 28.9 1.4 1 0 0 1 1 1 1 ABC-2 type transporter SMC_N PF02463.19 EFX00337.1 - 7.1e-07 28.9 0.0 3e-06 26.9 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EFX00337.1 - 1e-05 25.2 0.1 2e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX00337.1 - 1.1e-05 25.9 0.1 1.9e-05 25.1 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFX00337.1 - 0.00012 22.0 0.4 0.00027 20.9 0.2 1.6 2 0 0 2 2 1 1 RsgA GTPase AAA_21 PF13304.6 EFX00337.1 - 0.00016 21.6 0.1 0.17 11.6 0.2 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFX00337.1 - 0.00053 20.3 0.0 0.00096 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFX00337.1 - 0.00054 19.6 0.2 0.0011 18.7 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 EFX00337.1 - 0.0018 17.4 0.3 0.0033 16.5 0.3 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 EFX00337.1 - 0.0035 17.1 0.1 0.0068 16.2 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 EFX00337.1 - 0.0035 17.6 0.1 0.0056 16.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX00337.1 - 0.0043 16.8 0.4 0.0066 16.2 0.4 1.2 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EFX00337.1 - 0.0071 16.9 0.1 0.011 16.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFX00337.1 - 0.0073 16.4 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase NTPase_1 PF03266.15 EFX00337.1 - 0.0098 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 NTPase NACHT PF05729.12 EFX00337.1 - 0.011 15.6 0.1 0.026 14.4 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 EFX00337.1 - 0.016 15.6 0.1 0.094 13.1 0.1 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFX00337.1 - 0.029 14.9 0.1 0.062 13.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFX00337.1 - 0.034 13.8 0.1 0.051 13.2 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 EFX00337.1 - 0.045 14.2 0.0 0.094 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EFX00337.1 - 0.047 13.7 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MobB PF03205.14 EFX00337.1 - 0.047 13.6 0.1 0.081 12.8 0.1 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 EFX00337.1 - 0.076 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFX00337.1 - 0.11 12.1 0.2 0.22 11.1 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EFX00337.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EFX00337.1 - 0.13 11.9 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase Rad17 PF03215.15 EFX00337.1 - 0.15 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_13 PF13166.6 EFX00337.1 - 0.15 10.7 0.1 1.5 7.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EFX00337.1 - 0.16 12.3 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFX00337.1 - 0.21 11.3 0.2 0.45 10.3 0.1 1.5 2 0 0 2 2 1 0 Conserved hypothetical ATP binding protein Septin PF00735.18 EFX00337.1 - 0.21 10.8 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 Septin ABC_ATPase PF09818.9 EFX00337.1 - 0.3 9.8 0.4 0.65 8.7 0.1 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class NicO PF03824.16 EFX00338.1 - 8.8e-64 215.6 3.3 8.8e-64 215.6 3.3 1.8 1 1 1 2 2 2 1 High-affinity nickel-transport protein RIX1 PF08167.12 EFX00339.1 - 3e-62 209.7 0.9 4.3e-62 209.2 0.2 1.7 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis PTN13_u3 PF16599.5 EFX00339.1 - 7.4 6.6 8.2 0.69 9.9 3.1 1.8 2 0 0 2 2 2 0 Unstructured linker region on PTN13 protein between PDZ Ldi PF18566.1 EFX00340.1 - 8.7e-78 262.0 0.0 1.6e-77 261.2 0.0 1.4 2 0 0 2 2 2 1 Linalool dehydratase/isomerase TFIIA PF03153.13 EFX00341.1 - 0.65 9.9 17.3 0.84 9.6 17.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Caldesmon PF02029.15 EFX00341.1 - 0.93 8.2 35.8 0.026 13.3 29.3 1.6 2 0 0 2 2 2 0 Caldesmon RR_TM4-6 PF06459.12 EFX00341.1 - 4.2 7.1 17.8 6.5 6.5 17.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paramyxo_ncap PF00973.19 EFX00341.1 - 4.5 6.1 7.6 6 5.7 7.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein COPR5 PF15340.6 EFX00341.1 - 5.7 7.6 10.9 9.3 6.9 10.9 1.3 1 0 0 1 1 1 0 Cooperator of PRMT5 family PPL5 PF18168.1 EFX00341.1 - 7.4 5.8 10.3 12 5.0 10.3 1.5 1 0 0 1 1 1 0 Prim-pol family 5 TRAPP PF04051.16 EFX00342.1 - 1.4e-45 154.6 0.0 2.9e-45 153.6 0.0 1.5 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component FAM199X PF15814.5 EFX00342.1 - 0.46 9.5 2.2 0.66 9.0 2.2 1.2 1 0 0 1 1 1 0 Protein family FAM199X Mtc PF03820.17 EFX00343.1 - 3.1e-119 397.6 0.0 3.5e-119 397.5 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier V-SNARE PF05008.15 EFX00344.1 - 0.0014 18.9 3.7 0.0014 18.9 3.7 2.4 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Seryl_tRNA_N PF02403.22 EFX00344.1 - 0.083 13.1 19.8 0.34 11.2 3.0 2.7 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SHE3 PF17078.5 EFX00344.1 - 0.2 11.3 11.7 25 4.5 11.7 2.3 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Lectin_N PF03954.14 EFX00344.1 - 0.83 9.4 4.6 19 5.0 1.4 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain UCH_C PF18031.1 EFX00344.1 - 2 8.4 6.3 0.16 11.9 1.1 1.9 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolases DUF1664 PF07889.12 EFX00344.1 - 2.4 8.2 13.7 0.44 10.6 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Troponin PF00992.20 EFX00344.1 - 3.3 8.0 11.9 2 8.7 2.1 2.5 2 0 0 2 2 2 0 Troponin DUF3450 PF11932.8 EFX00344.1 - 4 6.7 20.5 0.53 9.5 9.5 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Abhydrolase_1 PF00561.20 EFX00345.1 - 5.4e-08 32.8 0.0 1.9e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX00345.1 - 1.5e-05 25.7 7.3 0.00018 22.2 7.3 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX00345.1 - 2.4e-05 23.7 0.0 0.0046 16.3 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Mito_carr PF00153.27 EFX00346.1 - 1.1e-52 175.9 2.4 4.3e-18 65.0 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L29e PF01779.17 EFX00346.1 - 7.7e-21 74.1 8.9 1.9e-20 72.9 8.9 1.7 1 0 0 1 1 1 1 Ribosomal L29e protein family Serine_protease PF18405.1 EFX00346.1 - 0.071 12.3 2.9 0.19 10.8 0.1 2.8 3 1 0 3 3 3 0 Gammaproteobacterial serine protease PrcB_C PF14343.6 EFX00346.1 - 0.22 11.7 0.9 13 6.0 0.0 3.3 3 1 1 4 4 4 0 PrcB C-terminal Hexapep_2 PF14602.6 EFX00347.1 - 2.5e-11 43.1 13.2 4.1e-08 32.8 5.0 3.5 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 EFX00347.1 - 6.9e-10 38.3 11.8 2.7e-08 33.2 4.5 3.6 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 EFX00347.1 - 8.4e-08 32.3 0.2 2.1e-07 31.0 0.2 1.7 1 0 0 1 1 1 1 Maltose acetyltransferase Metallophos PF00149.28 EFX00348.1 - 4.1e-40 138.5 0.1 5.3e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFX00348.1 - 2e-22 79.3 1.9 2.9e-22 78.8 1.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Peptidase_M18 PF02127.15 EFX00349.1 - 2.1e-167 557.3 0.0 2.5e-167 557.1 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EFX00349.1 - 2e-05 23.8 0.0 0.00031 19.9 0.0 2.5 2 1 1 3 3 3 1 M42 glutamyl aminopeptidase Ribosomal_L23eN PF03939.13 EFX00350.1 - 8.2e-23 80.4 14.3 8.2e-23 80.4 14.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EFX00350.1 - 1.5e-16 60.5 0.7 1.5e-16 60.5 0.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L23 SRP54 PF00448.22 EFX00352.1 - 8.3e-77 257.3 2.4 2.1e-76 256.0 1.8 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFX00352.1 - 2.1e-30 105.3 4.9 2.1e-30 105.3 4.9 3.9 2 2 2 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 EFX00352.1 - 1.5e-20 73.2 0.3 5.5e-20 71.4 0.4 2.0 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EFX00352.1 - 7.5e-07 28.9 0.9 6.8e-06 25.8 1.1 2.4 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EFX00352.1 - 2.9e-06 27.5 0.0 7.6e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFX00352.1 - 0.0001 22.7 0.1 0.00035 21.0 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX00352.1 - 0.00013 22.4 0.0 0.00029 21.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Thymidylate_kin PF02223.17 EFX00352.1 - 0.003 17.3 0.1 0.028 14.1 0.0 2.4 2 0 0 2 2 2 1 Thymidylate kinase APS_kinase PF01583.20 EFX00352.1 - 0.0038 17.1 0.0 0.0081 16.1 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 EFX00352.1 - 0.0048 16.2 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin MeaB PF03308.16 EFX00352.1 - 0.0055 15.7 4.2 0.0099 14.9 1.5 2.5 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EFX00352.1 - 0.0062 16.3 0.1 0.0062 16.3 0.1 1.9 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 EFX00352.1 - 0.0078 16.5 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EFX00352.1 - 0.01 15.6 0.3 0.049 13.4 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EFX00352.1 - 0.015 15.4 0.4 0.2 11.7 0.2 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase SRPRB PF09439.10 EFX00352.1 - 0.018 14.5 0.8 5.7 6.3 0.8 3.2 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 EFX00352.1 - 0.021 15.4 0.0 0.052 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFX00352.1 - 0.031 14.2 0.9 1.3 8.9 0.9 2.5 1 1 0 1 1 1 0 NTPase ResIII PF04851.15 EFX00352.1 - 0.037 14.0 0.4 0.18 11.8 0.4 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 EFX00352.1 - 0.038 14.2 0.1 0.07 13.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EFX00352.1 - 0.05 14.0 0.1 0.2 12.1 0.1 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 EFX00352.1 - 0.051 13.5 0.1 0.17 11.8 0.0 2.0 3 0 0 3 3 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 EFX00352.1 - 0.055 13.5 0.0 0.15 12.1 0.0 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF3052 PF11253.8 EFX00352.1 - 0.15 11.9 0.4 0.69 9.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3052) SKA2 PF16740.5 EFX00352.1 - 0.19 11.6 4.2 5.4 6.8 1.2 2.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Pyridox_ox_2 PF12900.7 EFX00355.1 - 1.7e-28 99.4 0.6 3.1e-28 98.5 0.3 1.5 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Glyco_hydro_3_C PF01915.22 EFX00356.1 - 3.9e-57 193.5 0.0 7e-57 192.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX00356.1 - 1.7e-44 152.5 0.0 2.9e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX00356.1 - 2.2e-16 59.7 0.0 5.1e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EFX00356.1 - 1.5e-11 44.3 0.0 3e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 PA14 domain TPR_12 PF13424.6 EFX00356.1 - 3.6e-08 33.6 10.2 0.0015 18.7 0.6 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat NB-ARC PF00931.22 EFX00356.1 - 2.9e-05 23.4 0.0 5.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_1 PF00515.28 EFX00356.1 - 0.0033 17.2 0.2 1.1 9.2 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00356.1 - 0.014 15.4 3.6 1.8 8.9 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Lipase_GDSL_2 PF13472.6 EFX00356.1 - 0.023 15.1 0.0 0.077 13.4 0.0 1.9 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family zf-rbx1 PF12678.7 EFX00358.1 - 5.9e-25 87.3 13.0 8.2e-25 86.9 13.0 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFX00358.1 - 5.2e-17 61.7 9.8 6.7e-17 61.3 9.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFX00358.1 - 3.8e-06 27.1 14.3 0.00013 22.2 14.3 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFX00358.1 - 5.1e-05 23.0 3.0 5.1e-05 23.0 3.0 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX00358.1 - 0.0019 18.1 11.6 0.031 14.1 11.6 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFX00358.1 - 0.0028 17.4 2.4 0.0028 17.4 2.4 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EFX00358.1 - 0.19 11.6 10.7 0.53 10.2 4.3 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX00358.1 - 0.56 10.3 7.2 2.2 8.4 7.2 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 EFX00358.1 - 0.83 9.9 9.2 4.2 7.6 9.4 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EFX00358.1 - 1.3 8.7 14.9 0.33 10.6 4.9 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EFX00358.1 - 7 6.7 12.4 64 3.6 12.4 2.5 1 1 0 1 1 1 0 zinc-RING finger domain Ribonuc_P_40 PF08584.11 EFX00359.1 - 2e-55 188.1 0.0 2.6e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit EB1 PF03271.17 EFX00360.1 - 1.8e-16 60.1 2.4 3.7e-16 59.1 2.4 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EFX00360.1 - 4.1e-06 26.9 0.3 8.5e-06 25.9 0.2 1.5 2 0 0 2 2 2 1 Calponin homology (CH) domain p450 PF00067.22 EFX00361.1 - 4.1e-64 217.0 0.0 5.4e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_A21 PF03566.13 EFX00361.1 - 0.16 10.2 0.0 0.23 9.7 0.0 1.1 1 0 0 1 1 1 0 Peptidase family A21 PEPCK_ATP PF01293.20 EFX00362.1 - 4.9e-212 704.7 0.0 5.7e-212 704.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 EFX00362.1 - 0.23 11.6 0.1 0.4 10.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain SBDS_C PF09377.10 EFX00364.1 - 3.1e-43 146.5 0.0 4.9e-43 145.8 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EFX00364.1 - 4e-32 110.1 0.0 7.6e-32 109.3 0.0 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Ribosomal_60s PF00428.19 EFX00364.1 - 0.04 14.5 6.0 0.04 14.5 6.0 3.6 2 1 0 2 2 2 0 60s Acidic ribosomal protein Glyco_hydro_72 PF03198.14 EFX00365.1 - 6.9e-122 406.6 4.5 1.2e-121 405.8 4.5 1.3 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EFX00365.1 - 7.4e-19 68.2 5.6 7.4e-19 68.2 5.6 2.2 2 0 0 2 2 2 1 X8 domain zf-H2C2_2 PF13465.6 EFX00366.1 - 1.7e-13 50.3 9.3 4.6e-08 33.1 0.6 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EFX00366.1 - 1.5e-11 44.1 13.1 4.1e-06 27.0 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX00366.1 - 4.1e-08 33.4 12.9 0.0005 20.7 1.6 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFX00366.1 - 3.5e-06 26.9 8.5 0.00026 20.9 0.4 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFX00366.1 - 2.8e-05 24.3 2.1 0.19 12.1 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX00366.1 - 0.0013 19.1 4.0 0.011 16.2 0.3 3.3 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EFX00366.1 - 0.14 12.5 1.7 0.29 11.5 1.7 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 EFX00366.1 - 0.17 11.7 6.2 1.4 8.7 1.0 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type LIM PF00412.22 EFX00366.1 - 0.44 10.8 4.0 5.7 7.3 0.1 2.4 1 1 0 2 2 2 0 LIM domain Methyltr_RsmB-F PF01189.17 EFX00368.1 - 1.8e-16 60.4 0.0 1.4e-10 41.2 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F DnaJ PF00226.31 EFX00369.1 - 3.1e-15 56.0 0.8 7.3e-15 54.9 0.8 1.6 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EFX00369.1 - 4.5e-10 39.1 0.0 2.6e-05 23.5 0.0 2.6 2 1 0 2 2 2 2 Sec63 Brl domain TetR_C_16 PF17920.1 EFX00369.1 - 0.018 15.3 0.1 0.088 13.0 0.1 2.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Acyltransferase PF01553.21 EFX00370.1 - 2.6e-32 111.3 0.0 4e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Peptidase_M24 PF00557.24 EFX00371.1 - 4.3e-07 29.8 0.0 5.7e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 CUE PF02845.16 EFX00372.1 - 2.4e-05 23.9 0.0 4.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF3697 PF12478.8 EFX00372.1 - 0.056 13.6 1.4 0.095 12.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-associated protein 2 Methyltransf_23 PF13489.6 EFX00374.1 - 2.5e-18 66.5 0.0 5.6e-18 65.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00374.1 - 1.5e-14 54.4 0.0 2.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00374.1 - 2.9e-14 53.5 0.0 6.1e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00374.1 - 2.4e-08 33.9 0.0 0.0029 17.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00374.1 - 3e-08 34.3 0.0 7.8e-08 33.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX00374.1 - 1.4e-05 24.5 0.0 0.00015 21.1 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFX00374.1 - 0.00048 19.7 0.0 0.008 15.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX00374.1 - 0.0014 18.1 0.0 0.0089 15.5 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.15 EFX00374.1 - 0.0023 17.8 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_16 PF10294.9 EFX00374.1 - 0.0084 15.9 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFX00374.1 - 0.013 14.9 0.0 0.028 13.8 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EFX00374.1 - 0.037 13.3 0.0 0.3 10.3 0.0 2.0 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF938 PF06080.12 EFX00374.1 - 0.078 12.7 0.0 0.31 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF938) Flavokinase PF01687.17 EFX00375.1 - 3.1e-10 40.3 0.0 5.7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase Chitin_synth_1 PF01644.17 EFX00375.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Chitin synthase Ecl1 PF12855.7 EFX00375.1 - 3.8 8.7 8.5 8.3 7.5 8.5 1.5 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins PhoLip_ATPase_C PF16212.5 EFX00376.1 - 2.1e-69 234.1 23.2 2.1e-69 234.1 23.2 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFX00376.1 - 3.3e-23 81.1 3.8 3.1e-22 78.0 0.5 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFX00376.1 - 3.1e-12 46.4 0.0 9.1e-11 41.7 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFX00376.1 - 3.8e-12 46.1 0.0 3.8e-12 46.1 0.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFX00376.1 - 1.6e-11 44.9 2.8 0.00061 20.1 0.5 4.0 3 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFX00376.1 - 0.00027 20.7 0.0 0.00079 19.2 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase BP28CT PF08146.12 EFX00377.1 - 1.2e-34 119.5 0.0 4e-34 117.8 0.0 2.0 1 0 0 1 1 1 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EFX00377.1 - 3.6e-26 91.8 2.3 6.6e-25 87.7 0.1 3.9 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 SP24 PF16504.5 EFX00377.1 - 0.022 14.8 1.2 0.074 13.1 0.1 2.3 2 0 0 2 2 2 0 Putative virion membrane protein of plant and insect virus DUF4081 PF13312.6 EFX00377.1 - 0.024 14.8 0.7 0.22 11.8 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4081) HEAT PF02985.22 EFX00377.1 - 0.029 14.6 13.0 0.034 14.4 0.1 6.3 6 0 0 6 6 6 0 HEAT repeat UNC45-central PF11701.8 EFX00377.1 - 0.034 14.1 1.1 33 4.4 0.0 4.1 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central DIOX_N PF14226.6 EFX00378.1 - 3.2e-25 89.2 0.0 4.7e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX00378.1 - 8.8e-19 67.9 0.0 1.5e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF898 PF05987.13 EFX00380.1 - 0.22 10.5 9.9 0.17 10.9 8.8 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) RNA_pol_Rpb6 PF01192.22 EFX00381.1 - 1.8e-16 59.8 0.1 2.8e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-H2C2_2 PF13465.6 EFX00383.1 - 2.2e-05 24.6 7.3 4e-05 23.8 4.1 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EFX00383.1 - 3.4e-05 24.1 3.9 3.4e-05 24.1 3.9 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX00383.1 - 4.1e-05 24.1 2.2 4.1e-05 24.1 2.2 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFX00383.1 - 0.00057 20.1 0.8 0.00057 20.1 0.8 2.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EFX00383.1 - 0.0024 17.8 1.6 0.0024 17.8 1.6 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EFX00383.1 - 0.16 12.3 2.7 0.43 10.9 2.7 1.8 1 0 0 1 1 1 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 EFX00383.1 - 0.18 12.5 7.4 1 10.0 0.3 3.4 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-TRAF PF02176.18 EFX00383.1 - 0.37 11.5 7.0 0.12 13.1 3.6 1.9 2 0 0 2 2 2 0 TRAF-type zinc finger GEMIN8 PF15348.6 EFX00383.1 - 2.1 8.6 6.0 7.7 6.7 0.1 2.3 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 zf-C2HE PF16278.5 EFX00383.1 - 7.2 7.1 6.7 4.4 7.8 4.3 2.0 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Fungal_trans PF04082.18 EFX00384.1 - 3.9e-12 45.8 0.4 7.4e-12 44.9 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX00384.1 - 8.3e-08 32.2 12.9 1.6e-07 31.3 12.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_7 PF13508.7 EFX00386.1 - 0.0042 17.5 0.0 0.0096 16.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX00386.1 - 0.0097 16.1 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family LMBR1 PF04791.16 EFX00387.1 - 4.7e-110 368.9 2.6 5.4e-110 368.7 2.6 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_S10 PF00338.22 EFX00388.1 - 7.7e-26 90.2 0.2 9.2e-26 89.9 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fungal_trans PF04082.18 EFX00389.1 - 8.7e-07 28.2 0.0 1.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ARD PF03079.14 EFX00391.1 - 3.1e-43 147.6 0.0 3.8e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EFX00391.1 - 6.9e-09 35.3 0.1 1.1e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EFX00391.1 - 3.7e-07 30.1 0.0 5.3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Ank_4 PF13637.6 EFX00392.1 - 2.5e-25 88.5 8.2 3.9e-10 40.1 0.2 3.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX00392.1 - 5.5e-23 81.4 0.9 7e-19 68.2 1.4 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFX00392.1 - 4.2e-21 74.4 1.9 1.7e-07 31.3 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFX00392.1 - 3e-18 64.0 1.4 1.9e-06 27.7 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFX00392.1 - 5.8e-17 61.5 7.0 5.9e-10 39.2 0.6 3.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Bmt2 PF11968.8 EFX00393.1 - 4.7e-83 278.4 0.0 6.2e-83 278.0 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EFX00393.1 - 2.2e-05 24.4 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CBFD_NFYB_HMF PF00808.23 EFX00394.1 - 2.6e-19 69.2 0.5 4.2e-19 68.6 0.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFX00394.1 - 5.5e-15 55.9 0.2 8.3e-15 55.3 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EFX00394.1 - 0.05 13.9 0.1 0.086 13.2 0.1 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF2040 PF09745.9 EFX00395.1 - 4.1e-36 123.7 19.8 4.1e-36 123.7 19.8 4.2 3 1 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) PDCD7 PF16021.5 EFX00396.1 - 0.0085 15.3 4.7 0.014 14.5 4.7 1.2 1 0 0 1 1 1 1 Programmed cell death protein 7 YabA PF06156.13 EFX00396.1 - 0.5 11.0 3.5 0.89 10.2 3.5 1.3 1 0 0 1 1 1 0 Initiation control protein YabA SMN PF06003.12 EFX00396.1 - 0.59 9.3 4.4 1.1 8.5 4.4 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) RXLR PF16810.5 EFX00396.1 - 0.72 10.3 5.2 1.6 9.2 5.2 1.5 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity OmpH PF03938.14 EFX00396.1 - 2.4 8.5 7.5 4.1 7.7 7.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GCV_H PF01597.19 EFX00397.1 - 2e-33 114.9 0.5 2.6e-33 114.5 0.5 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 EFX00397.1 - 0.045 13.7 0.2 0.076 13.0 0.2 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 EFX00397.1 - 0.053 13.3 0.1 0.092 12.6 0.1 1.4 1 0 0 1 1 1 0 Biotin-requiring enzyme Aminotran_5 PF00266.19 EFX00398.1 - 2.2e-09 36.8 0.0 3.4e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Adaptin_N PF01602.20 EFX00401.1 - 4e-93 312.8 3.2 6.8e-93 312.0 3.2 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EFX00401.1 - 4.5e-59 198.4 0.2 9.5e-59 197.3 0.2 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EFX00401.1 - 3e-55 185.6 0.0 7.8e-55 184.3 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EFX00401.1 - 4.1e-13 49.7 0.8 1.6e-08 34.7 0.0 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFX00401.1 - 3e-08 33.9 2.7 0.002 18.5 0.0 5.0 1 1 3 4 4 4 3 HEAT repeats HEAT PF02985.22 EFX00401.1 - 0.00082 19.4 0.8 1.3 9.4 0.1 4.3 4 0 0 4 4 4 1 HEAT repeat DUF5578 PF17741.1 EFX00401.1 - 0.025 14.0 2.4 2.6 7.4 0.1 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5578) HEAT_EZ PF13513.6 EFX00401.1 - 0.034 14.7 0.5 26 5.5 0.0 3.6 3 1 0 3 3 3 0 HEAT-like repeat Abhydrolase_3 PF07859.13 EFX00403.1 - 1.7e-54 184.9 0.1 2.4e-54 184.4 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFX00403.1 - 1.1e-08 34.4 0.0 2.5e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 EFX00403.1 - 0.016 14.7 0.1 0.03 13.8 0.1 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EFX00403.1 - 0.046 13.2 0.1 0.2 11.1 0.1 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EFX00403.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFX00403.1 - 6 7.4 15.1 2.3 8.8 12.1 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family Pkinase PF00069.25 EFX00404.1 - 1.3e-46 159.1 0.0 1.9e-46 158.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00404.1 - 9.3e-23 80.8 0.0 2e-22 79.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EFX00404.1 - 0.028 13.4 0.0 0.041 12.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 EFX00404.1 - 0.19 11.3 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family DUF2575 PF10837.8 EFX00405.1 - 0.068 13.5 0.2 1.4 9.2 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2575) MFS_1 PF07690.16 EFX00406.1 - 1.6e-21 76.6 38.4 6.4e-21 74.7 29.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2721 PF11026.8 EFX00406.1 - 3.1 7.7 0.0 3.1 7.7 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) GWT1 PF06423.12 EFX00407.1 - 0.46 10.6 6.1 0.23 11.6 3.3 1.9 2 1 0 2 2 2 0 GWT1 PIG-Y PF15159.6 EFX00407.1 - 1.5 9.8 11.6 0.095 13.6 1.6 3.2 3 0 0 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF3237 PF11578.8 EFX00408.1 - 1.3e-18 67.3 0.6 3.3e-14 53.0 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3237) Aldo_ket_red PF00248.21 EFX00409.1 - 4.8e-41 140.9 0.0 2.7e-39 135.1 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 EFX00410.1 - 5.3e-26 91.4 48.7 6.8e-26 91.0 41.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Thioesterase PF00975.20 EFX00411.1 - 1.2e-16 61.5 0.1 2.3e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EFX00411.1 - 1.2e-07 32.6 7.4 2e-07 31.8 7.4 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX00411.1 - 0.0058 16.3 0.3 0.024 14.3 0.0 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EFX00411.1 - 0.018 14.9 0.0 0.027 14.3 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EFX00411.1 - 0.052 13.4 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Adap_comp_sub PF00928.21 EFX00412.1 - 1.3e-84 283.7 0.0 1.6e-84 283.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFX00412.1 - 7.2e-05 22.7 0.1 0.00013 21.9 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain E1-E2_ATPase PF00122.20 EFX00413.1 - 5.5e-28 97.7 0.2 5.5e-28 97.7 0.2 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFX00413.1 - 1.4e-20 74.5 0.2 2.9e-20 73.4 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFX00413.1 - 1.2e-10 41.7 0.0 2.5e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain HLH PF00010.26 EFX00414.1 - 5.2e-11 42.3 0.0 8.6e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MFMR PF07777.11 EFX00414.1 - 0.08 13.4 0.3 0.08 13.4 0.3 2.6 3 0 0 3 3 3 0 G-box binding protein MFMR FAM199X PF15814.5 EFX00414.1 - 0.51 9.3 8.3 1.1 8.3 8.3 1.4 1 0 0 1 1 1 0 Protein family FAM199X PCI PF01399.27 EFX00415.1 - 5.6e-08 33.2 1.8 1.6e-07 31.8 0.1 2.7 2 1 0 2 2 2 1 PCI domain DUF4758 PF15950.5 EFX00415.1 - 0.24 11.7 3.2 1.3 9.4 0.1 3.0 2 0 0 2 2 2 0 Putative sperm flagellar membrane protein CoA_transf_3 PF02515.17 EFX00417.1 - 9.2e-38 130.3 0.1 1.3e-37 129.8 0.1 1.2 1 0 0 1 1 1 1 CoA-transferase family III Peptidase_M16_M PF16187.5 EFX00418.1 - 3.6e-93 311.9 0.1 8.5e-93 310.7 0.1 1.7 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EFX00418.1 - 1.2e-34 119.9 0.0 3.5e-17 63.0 0.0 3.3 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFX00418.1 - 2.3e-33 115.3 0.0 6.1e-33 113.9 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) CAS_CSE1 PF03378.15 EFX00418.1 - 0.042 12.3 0.8 0.083 11.4 0.8 1.4 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus Importin_rep_3 PF18806.1 EFX00419.1 - 0.00021 21.3 0.0 0.0043 17.1 0.0 3.2 3 0 0 3 3 3 1 Importin 13 repeat DUF3385 PF11865.8 EFX00419.1 - 0.02 14.8 0.1 43 4.0 0.0 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) Gal4_dimer PF03902.13 EFX00419.1 - 0.029 14.5 0.2 2.1 8.6 0.0 2.7 2 0 0 2 2 2 0 Gal4-like dimerisation domain Xpo1 PF08389.12 EFX00419.1 - 0.084 12.9 5.5 0.2 11.7 0.0 4.0 5 1 1 6 6 6 0 Exportin 1-like protein zf-C2H2_4 PF13894.6 EFX00421.1 - 0.071 14.0 7.2 1.3 10.1 0.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Sec23_Sec24 PF04810.15 EFX00421.1 - 0.22 11.6 1.6 6 7.0 0.1 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger RdRP PF05183.12 EFX00422.1 - 2.6e-121 406.1 0.0 3.7e-121 405.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase LrgB PF04172.16 EFX00423.1 - 3.8e-19 69.1 18.5 5.9e-12 45.6 8.7 2.3 2 0 0 2 2 2 2 LrgB-like family PHD PF00628.29 EFX00425.1 - 7e-17 61.1 17.3 3.7e-10 39.5 7.9 2.4 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 EFX00425.1 - 0.0035 17.0 6.5 0.18 11.4 2.9 2.9 2 0 0 2 2 2 2 PHD/FYVE-zinc-finger like domain Zf_RING PF16744.5 EFX00425.1 - 0.044 13.9 6.6 0.65 10.2 0.3 2.7 2 0 0 2 2 2 0 KIAA1045 RING finger PHD_2 PF13831.6 EFX00425.1 - 0.16 11.6 7.0 1.5 8.4 2.7 2.7 2 0 0 2 2 2 0 PHD-finger zf-HC5HC2H PF13771.6 EFX00425.1 - 2.9 8.2 6.6 5.2 7.4 3.4 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.22 EFX00425.1 - 9.9 6.1 12.9 3.3 7.7 0.5 2.7 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4211 PF13926.6 EFX00426.1 - 5.3e-47 159.5 0.0 1.2e-46 158.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) Topoisom_bac PF01131.20 EFX00429.1 - 3.9e-81 273.2 0.0 1.2e-71 241.9 0.0 3.0 2 1 1 3 3 3 3 DNA topoisomerase Toprim PF01751.22 EFX00429.1 - 4.6e-17 62.1 0.0 4.5e-16 58.9 0.0 2.3 2 0 0 2 2 2 1 Toprim domain Annexin PF00191.20 EFX00430.1 - 5.9e-70 231.3 1.0 3.5e-19 68.6 0.0 4.4 4 1 0 4 4 4 4 Annexin Acetyltransf_11 PF13720.6 EFX00430.1 - 0.032 14.7 1.2 4.2 7.9 0.0 3.6 4 0 0 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 RIO1 PF01163.22 EFX00431.1 - 4.6e-60 202.4 2.2 4.7e-58 195.9 0.0 2.5 2 1 0 2 2 2 1 RIO1 family APH PF01636.23 EFX00431.1 - 0.0042 17.0 0.2 0.015 15.3 0.2 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFX00431.1 - 0.026 13.9 0.1 0.5 9.7 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2388 PF09498.10 EFX00431.1 - 0.095 12.7 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) Nop14 PF04147.12 EFX00431.1 - 0.3 9.2 11.8 0.41 8.8 11.8 1.1 1 0 0 1 1 1 0 Nop14-like family SR-25 PF10500.9 EFX00431.1 - 0.45 10.1 16.3 0.2 11.2 13.9 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TauD PF02668.16 EFX00433.1 - 1.8e-28 100.1 0.0 3.9e-28 99.0 0.0 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EFX00433.1 - 0.0022 17.2 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 CsiD 2OG-FeII_Oxy_3 PF13640.6 EFX00433.1 - 0.011 16.6 0.0 0.043 14.7 0.0 2.0 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Tfb2 PF03849.14 EFX00435.1 - 9.2e-136 452.5 0.0 8.2e-135 449.3 0.0 1.9 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EFX00435.1 - 3.2e-21 75.5 0.9 3.2e-21 75.5 0.9 1.7 2 0 0 2 2 2 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EFX00435.1 - 0.00099 19.3 0.3 0.0033 17.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Peptidase_M24 PF00557.24 EFX00436.1 - 2.6e-58 197.2 0.0 3.6e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFX00436.1 - 5.4e-22 77.8 0.0 1.1e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 EFX00436.1 - 0.24 11.4 0.1 0.43 10.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) SAM_decarbox PF01536.16 EFX00437.1 - 8.1e-103 344.1 0.0 2.3e-76 257.1 0.0 2.2 1 1 1 2 2 2 2 Adenosylmethionine decarboxylase Fungal_TACC PF12709.7 EFX00438.1 - 0.13 12.7 0.2 0.29 11.6 0.2 1.5 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Fungus-induced PF10917.8 EFX00438.1 - 1.2 9.5 3.7 5.1 7.5 3.7 2.0 1 0 0 1 1 1 0 Fungus-induced protein SR-25 PF10500.9 EFX00439.1 - 5.1 6.6 29.4 0.11 12.1 5.2 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein MutS_IV PF05190.18 EFX00440.1 - 1.9 8.9 3.3 63 4.0 3.5 2.3 2 0 0 2 2 2 0 MutS family domain IV tRNA-synt_1d PF00750.19 EFX00441.1 - 3e-65 220.5 0.0 4.4e-65 219.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFX00441.1 - 9.3e-14 51.6 0.0 1.7e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain DUF3889 PF13028.6 EFX00441.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3889) Peptidase_S9 PF00326.21 EFX00442.1 - 4.8e-24 85.0 0.3 5.8e-24 84.8 0.3 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2920 PF11144.8 EFX00442.1 - 0.044 13.0 0.0 0.055 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) COesterase PF00135.28 EFX00442.1 - 0.15 10.8 0.0 0.18 10.6 0.0 1.0 1 0 0 1 1 1 0 Carboxylesterase family TMA7 PF09072.10 EFX00444.1 - 9e-25 87.3 22.3 1e-24 87.1 22.3 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 DUF2423 PF10338.9 EFX00445.1 - 8.2e-19 67.6 5.4 1.6e-18 66.7 5.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Phosphodiest PF01663.22 EFX00445.1 - 5.7e-11 42.6 4.1 2.1e-09 37.5 0.4 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFX00445.1 - 0.0016 17.9 0.0 0.035 13.5 0.0 2.4 2 1 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EFX00445.1 - 0.05 13.0 0.1 0.12 11.7 0.1 1.5 2 0 0 2 2 2 0 Metalloenzyme superfamily Peptidase_M18 PF02127.15 EFX00447.1 - 3.6e-124 414.9 0.0 4.3e-124 414.6 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Sen15 PF09631.10 EFX00448.1 - 1.3e-21 76.7 0.0 4.3e-21 75.1 0.0 1.8 1 1 0 1 1 1 1 Sen15 protein Methyltransf_2 PF00891.18 EFX00449.1 - 9e-18 64.3 0.0 1.5e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain MarR_2 PF12802.7 EFX00449.1 - 0.02 14.8 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 MarR family MarR PF01047.22 EFX00449.1 - 0.036 14.0 0.0 0.15 12.0 0.0 2.0 2 0 0 2 2 2 0 MarR family Fe_dep_repress PF01325.19 EFX00449.1 - 0.14 12.3 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Hairy_orange PF07527.13 EFX00449.1 - 0.14 12.4 0.0 0.47 10.7 0.0 1.9 1 0 0 1 1 1 0 Hairy Orange ANT PF03374.14 EFX00449.1 - 0.17 12.2 0.0 6 7.2 0.0 2.3 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain PLDc_2 PF13091.6 EFX00450.1 - 2.2e-17 63.2 0.0 1.7e-11 44.2 0.0 3.0 3 2 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EFX00450.1 - 0.0003 20.9 0.0 0.02 15.1 0.0 2.5 2 0 0 2 2 2 1 Phospholipase D Active site motif G-gamma PF00631.22 EFX00451.1 - 8.5e-26 89.7 0.0 1.1e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 GGL domain Ribosomal_L11 PF00298.19 EFX00451.1 - 0.082 13.4 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11, RNA binding domain zf-CHCC PF10276.9 EFX00453.1 - 3.9e-15 55.6 2.6 6.2e-15 55.0 2.6 1.3 1 0 0 1 1 1 1 Zinc-finger domain PBAN PF05874.11 EFX00454.1 - 0.022 14.7 0.1 0.061 13.2 0.1 1.7 1 0 0 1 1 1 0 Pheromone biosynthesis activating neuropeptide (PBAN) zf-Tim10_DDP PF02953.15 EFX00455.1 - 7.6e-22 76.7 4.6 9.4e-22 76.4 4.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger STE PF02200.16 EFX00456.1 - 2.7e-56 188.7 0.1 4.5e-56 188.0 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EFX00456.1 - 0.00096 19.5 4.2 0.0023 18.3 4.2 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX00456.1 - 0.037 14.9 2.4 0.094 13.6 2.4 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger HNH_2 PF13391.6 EFX00457.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 HNH endonuclease Lipase_3 PF01764.25 EFX00458.1 - 2e-20 73.1 0.0 3.3e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EFX00458.1 - 0.047 14.3 0.0 0.089 13.4 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EFX00458.1 - 0.18 11.5 0.1 0.35 10.6 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein zf-C2H2 PF00096.26 EFX00459.1 - 0.1 13.1 4.3 0.26 11.8 4.3 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type Fer2 PF00111.27 EFX00460.1 - 1.3e-12 47.5 1.0 1.3e-12 47.5 1.0 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain FAD_binding_4 PF01565.23 EFX00462.1 - 9.4e-19 67.5 1.7 1.9e-18 66.6 1.2 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EFX00462.1 - 3.1e-05 24.0 0.0 9.2e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 Berberine and berberine like Homeodomain PF00046.29 EFX00463.1 - 2.1e-19 69.1 3.7 4.1e-19 68.2 3.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EFX00463.1 - 0.022 14.6 0.6 0.061 13.2 0.6 1.8 1 0 0 1 1 1 0 Homeobox KN domain DUF908 PF06012.12 EFX00463.1 - 4.9 6.5 9.4 11 5.3 9.4 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CorA PF01544.18 EFX00464.1 - 2.4e-05 23.8 0.1 4.9e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Oxidored-like PF09791.9 EFX00465.1 - 2.6e-23 81.4 3.5 5.4e-23 80.4 3.5 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF3484 PF11983.8 EFX00465.1 - 0.03 15.4 0.0 0.067 14.3 0.0 1.6 1 0 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch PI-PLC-X PF00388.19 EFX00466.1 - 1.9e-61 205.9 0.0 3e-61 205.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFX00466.1 - 5.5e-43 146.0 0.5 1.3e-42 144.8 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain SR-25 PF10500.9 EFX00466.1 - 0.16 11.6 18.8 0.024 14.2 13.8 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 EFX00466.1 - 0.67 8.2 8.3 1.1 7.5 8.3 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EFX00466.1 - 0.99 9.5 14.5 0.031 14.4 6.7 2.0 2 0 0 2 2 2 0 YL1 nuclear protein TFIIF_alpha PF05793.12 EFX00466.1 - 1.3 7.5 12.8 2.5 6.6 12.8 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SIR4_SID PF16991.5 EFX00466.1 - 1.7 8.7 8.8 0.6 10.1 5.6 1.8 2 0 0 2 2 2 0 Sir4 SID domain FSA_C PF10479.9 EFX00466.1 - 3.6 5.6 9.9 6.9 4.7 9.9 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MG4 PF17789.1 EFX00466.1 - 8.5 6.6 7.0 9.7 6.4 2.3 2.9 2 0 0 2 2 2 0 Macroglobulin domain MG4 Methyltransf_25 PF13649.6 EFX00467.1 - 7.4e-11 42.6 0.0 7e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EFX00467.1 - 1.6e-08 34.6 0.0 3.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00467.1 - 3.9e-08 33.8 0.0 3.6e-07 30.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00467.1 - 2.6e-05 24.0 0.0 0.08 12.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00467.1 - 0.00079 20.1 0.0 0.0038 17.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFX00467.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CheR PF01739.18 EFX00467.1 - 0.22 11.0 0.0 0.79 9.2 0.0 1.8 1 1 0 1 1 1 0 CheR methyltransferase, SAM binding domain MFS_1 PF07690.16 EFX00468.1 - 1.4e-26 93.3 28.7 2.4e-26 92.5 28.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily FixQ PF05545.11 EFX00468.1 - 0.023 14.6 15.4 0.028 14.4 1.0 4.5 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ OPT PF03169.15 EFX00469.1 - 7.8e-89 299.0 21.8 1e-88 298.5 21.8 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Isochorismatase PF00857.20 EFX00469.1 - 6.6e-18 65.5 0.0 1.2e-17 64.7 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family Cyclin PF08613.11 EFX00470.1 - 2.6e-42 144.9 0.0 4.1e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin ADH_zinc_N_2 PF13602.6 EFX00471.1 - 1.6e-19 71.3 0.0 3.3e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFX00471.1 - 1.7e-15 57.2 0.0 5.1e-15 55.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX00471.1 - 7.7e-05 22.5 0.0 0.004 17.0 0.0 2.8 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain DFP PF04127.15 EFX00471.1 - 0.0021 17.9 0.1 0.0036 17.1 0.1 1.4 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein NAD_binding_10 PF13460.6 EFX00471.1 - 0.0039 17.1 0.4 0.059 13.3 0.1 2.2 2 0 0 2 2 2 1 NAD(P)H-binding DapB_N PF01113.20 EFX00471.1 - 0.053 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Eno-Rase_NADH_b PF12242.8 EFX00471.1 - 0.064 13.0 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1699 PF08004.11 EFX00472.1 - 0.18 11.5 0.3 0.69 9.6 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1699) CorA PF01544.18 EFX00473.1 - 1.2e-41 143.0 0.2 1.7e-41 142.5 0.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein UQ_con PF00179.26 EFX00474.1 - 6.5e-21 74.4 0.0 8.7e-21 74.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Lectin_leg-like PF03388.13 EFX00475.1 - 2.3e-66 223.4 0.0 3.1e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 EFX00475.1 - 0.00019 21.0 0.0 0.47 10.0 0.0 2.2 1 1 1 2 2 2 2 Legume lectin domain FAA_hydrolase PF01557.18 EFX00476.1 - 1.6e-66 224.1 0.0 2.5e-66 223.5 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_1 PF00561.20 EFX00476.1 - 2.5e-22 79.8 0.1 1.4e-19 70.7 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX00476.1 - 3.8e-19 70.2 8.1 7.1e-19 69.3 8.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX00476.1 - 1.7e-18 66.8 0.1 3.8e-18 65.6 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EFX00476.1 - 9.7e-12 45.1 3.2 5.4e-06 26.4 0.2 2.3 1 1 1 2 2 2 2 Serine hydrolase Abhydrolase_4 PF08386.10 EFX00476.1 - 6.5e-07 29.4 0.1 1.6e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_5 PF12695.7 EFX00476.1 - 0.017 14.9 0.0 5.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family PhoPQ_related PF10142.9 EFX00476.1 - 0.047 12.3 0.0 0.065 11.9 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein FSH1 PF03959.13 EFX00476.1 - 0.075 12.7 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EFX00476.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EFX00476.1 - 0.18 10.7 0.1 0.86 8.5 0.1 2.0 2 0 0 2 2 2 0 Chlorophyllase enzyme TPR_1 PF00515.28 EFX00477.1 - 1.4e-32 110.1 17.7 5.8e-07 29.1 0.1 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00477.1 - 1.1e-29 100.1 23.4 1.7e-05 24.6 0.0 8.4 8 1 0 8 8 8 7 Tetratricopeptide repeat DnaJ PF00226.31 EFX00477.1 - 1.1e-27 96.0 5.8 1.4e-27 95.6 3.7 2.2 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.6 EFX00477.1 - 7.7e-23 79.9 14.8 3.5e-05 23.4 0.0 6.5 5 2 1 6 6 6 5 TPR repeat TPR_19 PF14559.6 EFX00477.1 - 5.5e-19 68.5 20.7 1.5e-07 31.8 0.6 5.5 5 2 1 6 6 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00477.1 - 5.8e-18 65.3 34.0 6.1e-07 30.0 1.1 6.7 6 1 1 7 7 5 5 Tetratricopeptide repeat TPR_9 PF13371.6 EFX00477.1 - 3.4e-13 49.5 14.9 0.0049 17.0 0.1 5.4 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFX00477.1 - 8.7e-13 47.4 10.1 0.017 15.3 0.4 6.9 8 1 0 8 8 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFX00477.1 - 2.7e-12 46.2 13.7 0.0029 17.9 0.0 7.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX00477.1 - 1.3e-11 44.6 19.9 0.00083 19.6 0.7 7.1 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFX00477.1 - 6.3e-11 41.5 9.0 0.16 12.1 0.0 6.9 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFX00477.1 - 2.6e-09 37.1 28.7 0.0036 18.0 0.3 8.3 4 3 5 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX00477.1 - 5.7e-08 32.9 6.0 0.026 14.8 0.1 3.9 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 EFX00477.1 - 0.00018 20.9 1.6 0.22 11.0 0.0 3.5 3 0 0 3 3 3 2 SHNi-TPR TPR_6 PF13174.6 EFX00477.1 - 0.00033 21.1 20.2 1.6 9.5 0.0 8.7 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_4 PF07721.14 EFX00477.1 - 0.0014 19.1 7.0 0.02 15.5 0.3 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat BTAD PF03704.17 EFX00477.1 - 0.0031 18.0 11.3 3.9 7.9 0.0 4.4 3 1 0 3 3 3 1 Bacterial transcriptional activator domain Alkyl_sulf_dimr PF14863.6 EFX00477.1 - 0.0079 16.7 5.5 3.4 8.1 0.1 4.0 2 1 1 3 3 3 1 Alkyl sulfatase dimerisation DUF928 PF06051.12 EFX00477.1 - 0.014 15.3 1.8 0.027 14.3 1.0 1.9 1 1 1 2 2 2 0 Domain of Unknown Function (DUF928) RRM_3 PF08777.11 EFX00477.1 - 0.027 14.5 0.3 0.12 12.4 0.1 2.1 2 0 0 2 2 2 0 RNA binding motif Fis1_TPR_C PF14853.6 EFX00477.1 - 0.077 13.1 5.2 27 4.9 0.0 4.5 3 1 2 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 EFX00477.1 - 0.33 9.9 1.4 0.44 9.5 0.1 1.8 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 EFX00477.1 - 0.61 10.0 27.5 0.88 9.5 0.5 6.4 8 0 0 8 8 6 0 Tetratricopeptide repeat DUF627 PF04781.12 EFX00477.1 - 0.74 9.8 3.5 0.54 10.3 0.2 2.4 3 1 0 3 3 2 0 Protein of unknown function (DUF627) Com_YlbF PF06133.11 EFX00477.1 - 8.2 7.1 7.3 43 4.8 2.6 2.7 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DUF89 PF01937.19 EFX00478.1 - 7.3e-132 439.6 0.0 8.3e-132 439.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 p450 PF00067.22 EFX00479.1 - 1.1e-38 133.2 0.0 2.5e-38 132.0 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Ku PF02735.16 EFX00480.1 - 2.1e-33 115.7 0.0 3.5e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 EFX00480.1 - 2.4e-32 111.6 0.0 5.8e-32 110.4 0.0 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.15 EFX00480.1 - 2.6e-11 43.7 0.0 4.2e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 EFX00480.1 - 0.00035 20.9 0.0 0.00078 19.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain MFAP1 PF06991.11 EFX00481.1 - 6.6e-70 235.3 31.0 6.6e-70 235.3 31.0 3.1 3 1 0 3 3 3 1 Microfibril-associated/Pre-mRNA processing Na_H_Exchanger PF00999.21 EFX00483.1 - 3.3e-72 243.4 33.7 4.1e-72 243.1 33.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PepSY_TM PF03929.16 EFX00483.1 - 0.005 16.5 0.4 0.011 15.5 0.4 1.6 1 0 0 1 1 1 1 PepSY-associated TM region DUF4220 PF13968.6 EFX00483.1 - 0.19 11.1 0.0 0.19 11.1 0.0 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4220) Pam16 PF03656.13 EFX00484.1 - 3.7e-06 27.0 0.1 4.3e-06 26.8 0.1 1.3 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 EFX00484.1 - 1.5e-05 25.0 0.1 2.3e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.6 EFX00484.1 - 0.037 13.6 0.4 0.12 12.0 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) DUF676 PF05057.14 EFX00485.1 - 0.052 13.0 0.0 0.099 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Trp_oprn_chp PF09534.10 EFX00485.1 - 0.21 11.4 0.1 0.21 11.4 0.1 2.5 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DHquinase_II PF01220.19 EFX00485.1 - 0.32 10.6 11.7 21 4.8 0.0 5.9 1 1 6 7 7 7 0 Dehydroquinase class II Spc7 PF08317.11 EFX00485.1 - 3.4 6.5 25.8 0.13 11.1 11.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein GSH_synth_ATP PF03917.17 EFX00487.1 - 1.1e-133 445.6 0.0 1.3e-133 445.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EFX00487.1 - 9.7e-30 103.1 0.0 1.6e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Serglycin PF04360.12 EFX00487.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Serglycin UCH PF00443.29 EFX00488.1 - 3.7e-69 233.1 0.0 5.2e-69 232.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX00488.1 - 6.3e-11 42.4 0.0 0.00044 19.9 0.0 3.3 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFX00488.1 - 3.7e-10 40.3 0.0 7.9e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 DUSP domain zf-FPG_IleRS PF06827.14 EFX00488.1 - 0.029 14.2 1.2 5.8 6.9 0.1 2.6 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Zn_ribbon_SprT PF17283.2 EFX00488.1 - 0.84 9.6 3.1 0.62 10.0 0.5 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Methyltransf_23 PF13489.6 EFX00489.1 - 2.3e-17 63.3 0.0 3e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00489.1 - 3.2e-10 40.0 0.0 0.0002 21.2 0.0 2.4 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00489.1 - 5.2e-09 36.7 0.0 1.3e-08 35.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00489.1 - 1.4e-06 29.0 0.0 1.2e-05 26.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00489.1 - 9.3e-05 23.0 0.0 0.00018 22.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX00489.1 - 0.0011 18.5 0.0 0.026 14.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EFX00489.1 - 0.0021 18.2 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EFX00489.1 - 0.0041 16.9 0.0 0.0072 16.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFX00489.1 - 0.038 13.4 0.0 0.13 11.6 0.0 1.9 3 0 0 3 3 3 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EFX00489.1 - 0.13 11.7 0.0 0.38 10.2 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase F-box-like PF12937.7 EFX00490.1 - 0.052 13.4 0.0 0.052 13.4 0.0 3.7 4 0 0 4 4 4 0 F-box-like FMO-like PF00743.19 EFX00491.1 - 2.4e-13 49.3 0.0 1.5e-09 36.8 0.0 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFX00491.1 - 1.3e-12 47.7 0.0 4.5e-12 46.0 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX00491.1 - 8.3e-07 28.9 0.0 0.00015 21.5 0.0 3.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFX00491.1 - 9e-06 25.0 0.0 0.012 14.7 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFX00491.1 - 3.1e-05 23.3 0.0 0.0035 16.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX00491.1 - 5.9e-05 23.1 0.1 0.00096 19.2 0.0 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EFX00491.1 - 0.011 14.9 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EFX00491.1 - 0.018 14.3 0.0 0.34 10.1 0.0 2.6 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX00491.1 - 0.024 13.4 0.0 0.042 12.6 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 EFX00491.1 - 0.11 11.5 0.0 0.28 10.2 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EFX00491.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Type2_restr_D3 PF16902.5 EFX00492.1 - 0.0096 15.8 0.1 0.024 14.6 0.1 1.7 1 0 0 1 1 1 1 Type-2 restriction enzyme D3 domain IFT57 PF10498.9 EFX00492.1 - 0.21 10.5 0.1 0.34 9.8 0.1 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Baculo_PEP_C PF04513.12 EFX00492.1 - 0.28 11.2 16.6 1.2 9.1 10.0 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF674 PF05056.12 EFX00492.1 - 0.29 9.9 1.6 0.36 9.7 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF674) Orbi_NS3 PF01616.16 EFX00492.1 - 2.8 7.6 13.0 3 7.5 2.2 2.1 1 1 1 2 2 2 0 Orbivirus NS3 FUN14 PF04930.15 EFX00494.1 - 0.0016 18.8 1.4 0.0027 18.1 1.4 1.4 1 0 0 1 1 1 1 FUN14 family FMO-like PF00743.19 EFX00495.1 - 1.3e-14 53.5 0.4 5.5e-14 51.5 0.4 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX00495.1 - 8e-14 51.6 0.6 8.3e-12 45.0 1.4 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX00495.1 - 2.9e-11 43.1 0.0 1.5e-09 37.5 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX00495.1 - 8.1e-08 31.8 0.0 8.5e-06 25.1 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFX00495.1 - 9.7e-06 25.7 3.1 1.7e-05 24.9 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EFX00495.1 - 4.8e-05 22.8 0.4 0.12 11.7 0.1 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EFX00495.1 - 0.00088 19.8 3.5 0.069 13.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX00495.1 - 0.0015 18.2 7.8 0.002 17.8 1.9 2.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX00495.1 - 0.013 15.5 1.8 0.6 10.1 0.1 3.4 4 0 0 4 4 4 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 EFX00495.1 - 0.019 15.0 0.0 4.9 7.2 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EFX00495.1 - 0.065 13.1 0.7 0.13 12.1 0.7 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EFX00495.1 - 0.15 12.5 0.0 2.8 8.4 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding Amino_oxidase PF01593.24 EFX00495.1 - 0.19 11.0 0.0 0.45 9.8 0.0 1.6 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EFX00495.1 - 0.4 9.3 3.2 0.57 8.8 0.6 2.0 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.24 EFX00495.1 - 0.48 9.5 7.6 0.039 13.1 2.1 1.9 2 0 0 2 2 2 0 FAD binding domain Adap_comp_sub PF00928.21 EFX00496.1 - 2.1e-91 305.9 0.0 3.7e-91 305.2 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFX00496.1 - 1.6e-08 34.6 0.2 2.6e-08 33.9 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EFX00496.1 - 0.088 12.2 0.0 0.3 10.5 0.0 1.7 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain Voltage_CLC PF00654.20 EFX00498.1 - 4.2e-87 292.7 22.4 4.2e-87 292.7 22.4 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel FUSC PF04632.12 EFX00498.1 - 0.91 8.0 6.6 2 6.8 6.6 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family RSN1_7TM PF02714.15 EFX00499.1 - 2.6e-77 259.8 22.1 3.9e-77 259.2 22.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EFX00499.1 - 2.2e-39 135.5 0.2 3.3e-39 134.9 0.2 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EFX00499.1 - 2e-26 92.6 1.5 2e-26 92.6 1.5 2.0 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PseudoU_synth_1 PF01416.20 EFX00500.1 - 9.8e-10 38.9 0.0 2.3e-08 34.5 0.0 2.9 3 0 0 3 3 3 1 tRNA pseudouridine synthase DUF2347 PF09804.9 EFX00502.1 - 4.3e-93 312.0 0.0 6.6e-93 311.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EFX00502.1 - 3.8e-63 213.3 0.4 9.8e-63 212.0 0.4 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4484) SPA PF08616.10 EFX00502.1 - 0.00017 21.5 0.0 0.00066 19.6 0.0 1.8 1 1 0 1 1 1 1 Stabilization of polarity axis BUD22 PF09073.10 EFX00502.1 - 5.4 6.3 10.0 8.2 5.6 10.0 1.2 1 0 0 1 1 1 0 BUD22 DUF1295 PF06966.12 EFX00503.1 - 2.3e-38 132.0 9.0 3e-38 131.7 9.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EFX00503.1 - 0.065 13.7 0.2 4.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family TRI12 PF06609.13 EFX00504.1 - 6.1e-55 186.8 27.3 7.1e-55 186.5 27.3 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EFX00504.1 - 4.4e-29 101.5 51.5 4.4e-29 101.5 51.5 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EFX00504.1 - 9.1e-06 24.5 1.8 9.1e-06 24.5 1.8 3.7 2 1 3 5 5 5 2 MFS/sugar transport protein SH3_1 PF00018.28 EFX00505.1 - 3.6e-05 23.3 0.0 7.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFX00505.1 - 0.057 13.3 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Fungal_trans PF04082.18 EFX00506.1 - 6.6e-16 58.1 0.5 9e-16 57.7 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX00506.1 - 9.3e-08 32.1 8.9 1.6e-07 31.4 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EFX00507.1 - 1.3e-97 327.5 23.2 1.9e-97 327.0 23.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX00507.1 - 1.1e-31 110.0 34.0 1.8e-23 83.0 11.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2615 PF11027.8 EFX00507.1 - 0.77 9.9 2.2 34 4.6 0.5 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF2615) NDUF_B12 PF08122.12 EFX00509.1 - 0.96 9.5 2.9 1.1 9.3 1.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Opi1 PF08618.10 EFX00510.1 - 2.2e-41 142.5 7.1 1.2e-30 107.2 0.6 3.4 2 1 1 3 3 3 3 Transcription factor Opi1 ABATE PF07336.11 EFX00510.1 - 0.068 13.8 3.1 0.17 12.6 3.1 1.7 1 0 0 1 1 1 0 Putative stress-induced transcription regulator PPR_1 PF12854.7 EFX00511.1 - 0.22 11.3 0.1 0.39 10.5 0.1 1.4 1 0 0 1 1 1 0 PPR repeat TIP120 PF08623.10 EFX00512.1 - 1.7e-68 229.6 0.0 8.1e-65 217.7 0.0 4.5 5 1 1 6 6 6 1 TATA-binding protein interacting (TIP20) RTP1_C1 PF10363.9 EFX00512.1 - 6.9e-10 39.1 10.0 0.013 15.7 0.4 6.5 7 0 0 7 7 7 2 Required for nuclear transport of RNA pol II C-terminus 1 DRIM PF07539.12 EFX00512.1 - 2.1e-09 36.3 0.0 0.0027 16.1 0.0 5.0 4 1 0 4 4 4 2 Down-regulated in metastasis Cnd1 PF12717.7 EFX00512.1 - 2.1e-09 37.6 7.5 0.14 12.1 0.0 7.1 7 1 1 8 8 8 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFX00512.1 - 4.4e-09 36.6 38.7 0.12 12.8 0.4 9.3 7 2 1 9 9 9 4 HEAT repeats HEAT PF02985.22 EFX00512.1 - 1.1e-07 31.5 24.4 0.91 10.0 0.0 11.3 12 0 0 12 12 11 3 HEAT repeat Adaptin_N PF01602.20 EFX00512.1 - 6e-05 21.8 11.1 0.024 13.2 0.4 6.3 4 4 1 6 6 6 1 Adaptin N terminal region RIX1 PF08167.12 EFX00512.1 - 0.018 14.8 3.4 9 6.0 0.0 5.2 5 1 0 5 5 5 0 rRNA processing/ribosome biogenesis Ipi1_N PF12333.8 EFX00512.1 - 0.023 15.3 0.0 3.1 8.4 0.0 3.2 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation U3snoRNP10 PF12397.8 EFX00512.1 - 0.038 14.4 3.0 4.8 7.6 0.3 3.6 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 DUF5578 PF17741.1 EFX00512.1 - 0.039 13.4 4.8 6.9 6.0 0.0 4.0 4 0 0 4 4 4 0 Family of unknown function (DUF5578) UME PF08064.13 EFX00512.1 - 0.042 13.8 9.7 29 4.6 0.0 7.1 7 1 1 8 8 8 0 UME (NUC010) domain VHS PF00790.19 EFX00512.1 - 0.076 12.9 0.0 1.9 8.3 0.0 2.9 2 0 0 2 2 2 0 VHS domain Hpt PF01627.23 EFX00512.1 - 1.2 9.4 5.6 1.9 8.8 0.4 4.0 4 0 0 4 4 4 0 Hpt domain IFRD PF05004.13 EFX00512.1 - 2.9 6.9 14.8 2.6 7.1 0.0 5.6 6 1 1 7 7 7 0 Interferon-related developmental regulator (IFRD) Peptidase_S10 PF00450.22 EFX00513.1 - 2.3e-128 429.2 0.5 2.7e-128 429.0 0.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EFX00513.1 - 1.4e-11 45.1 0.0 3.6e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide adh_short PF00106.25 EFX00515.1 - 3.3e-07 30.0 0.0 5.6e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX00515.1 - 9.5e-07 28.9 0.1 1.6e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 KR domain Hpr_kinase_C PF07475.12 EFX00515.1 - 0.14 11.7 0.0 9.3 5.7 0.1 2.2 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain TIM PF00121.18 EFX00516.1 - 3.6e-45 154.3 0.0 4.3e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase Aminotran_1_2 PF00155.21 EFX00517.1 - 7.8e-62 209.5 0.0 1e-61 209.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFX00517.1 - 0.24 10.3 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Kinesin PF00225.23 EFX00519.1 - 3.2e-104 348.4 0.3 3.2e-104 348.4 0.3 2.3 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFX00519.1 - 3.5e-54 182.8 0.7 1.2e-52 177.8 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding AAA_16 PF13191.6 EFX00519.1 - 0.044 14.2 0.0 0.044 14.2 0.0 3.1 2 1 1 3 3 3 0 AAA ATPase domain AAA_24 PF13479.6 EFX00519.1 - 0.051 13.3 0.0 0.27 10.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFX00519.1 - 0.051 13.9 11.0 0.83 9.9 0.1 3.0 3 0 0 3 3 3 0 AAA domain FSH1 PF03959.13 EFX00520.1 - 3.1e-21 76.0 0.0 5e-21 75.4 0.0 1.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DUF2745 PF10922.8 EFX00520.1 - 0.063 13.6 0.1 4.3 7.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2745) 2OG-FeII_Oxy PF03171.20 EFX00521.1 - 2.6e-22 79.2 0.0 6.7e-22 77.9 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFX00521.1 - 2e-20 73.7 0.0 3e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal SET PF00856.28 EFX00522.1 - 4e-14 53.4 0.0 1.5e-13 51.4 0.0 1.9 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EFX00522.1 - 2.7e-11 44.3 0.8 6.6e-11 43.0 0.8 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding HTH_Tnp_Tc5 PF03221.16 EFX00523.1 - 2.8e-13 49.7 0.0 2.2e-12 46.8 0.0 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EFX00523.1 - 1.9e-05 24.2 0.0 3.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_4 PF13613.6 EFX00523.1 - 0.0097 15.6 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease LacI PF00356.21 EFX00523.1 - 0.067 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_Crp_2 PF13545.6 EFX00523.1 - 0.083 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain MarR PF01047.22 EFX00523.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_38 PF13936.6 EFX00523.1 - 0.17 11.7 0.2 0.66 9.8 0.0 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain Herpes_pp85 PF04637.12 EFX00524.1 - 0.23 9.9 0.0 0.34 9.3 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF3580 PF12117.8 EFX00526.1 - 0.48 10.6 2.3 0.71 10.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3580) HALZ PF02183.18 EFX00526.1 - 0.93 9.8 8.6 0.036 14.3 2.2 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper HlyIII PF03006.20 EFX00527.1 - 4.2e-60 203.2 10.5 4e-58 196.8 10.5 2.4 1 1 0 1 1 1 1 Haemolysin-III related CrgA PF06781.12 EFX00527.1 - 0.28 11.3 1.7 0.41 10.7 0.4 1.9 2 0 0 2 2 2 0 Cell division protein CrgA DHFR_1 PF00186.19 EFX00528.1 - 2.9e-30 105.1 0.0 3.6e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase zf-C2H2 PF00096.26 EFX00529.1 - 0.00088 19.6 15.1 0.048 14.1 1.7 4.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX00529.1 - 0.034 15.0 1.3 0.034 15.0 1.3 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX00529.1 - 0.4 11.2 11.2 3.8 8.1 1.2 3.4 3 0 0 3 3 3 0 Zinc-finger double domain SDA1 PF05285.12 EFX00529.1 - 0.85 9.0 9.2 1.3 8.4 9.2 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFX00529.1 - 1 7.5 9.0 1.5 7.0 9.0 1.1 1 0 0 1 1 1 0 Nop14-like family zf-Di19 PF05605.12 EFX00529.1 - 2.5 8.5 6.6 0.64 10.4 1.1 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CDC45 PF02724.14 EFX00529.1 - 3.3 5.9 6.8 4.8 5.4 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 EFX00529.1 - 9.2 5.4 5.8 16 4.6 5.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pre-PUA PF17832.1 EFX00530.1 - 4.4e-19 68.9 0.2 6.2e-19 68.5 0.2 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EFX00530.1 - 7.4e-11 41.9 0.1 7.5e-10 38.6 0.1 2.0 1 1 0 1 1 1 1 PUA domain DER1 PF04511.15 EFX00531.1 - 3.6e-51 173.8 9.9 4.1e-51 173.6 9.9 1.0 1 0 0 1 1 1 1 Der1-like family His_Phos_2 PF00328.22 EFX00532.1 - 7.4e-05 22.3 0.9 0.0015 18.0 0.0 2.6 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 2) Secretin_N_2 PF07655.13 EFX00532.1 - 2.7 8.6 10.2 2.5 8.7 4.9 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain UFD1 PF03152.14 EFX00533.1 - 1.2e-27 96.4 0.0 2.6e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EFX00533.1 - 7.2e-06 26.1 0.0 7.2e-06 26.1 0.0 2.7 3 0 0 3 3 3 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Man-6-P_recep PF02157.15 EFX00534.1 - 3.5e-14 52.5 0.0 6e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EFX00534.1 - 1.3e-11 44.9 0.0 3.6e-11 43.4 0.0 1.8 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EFX00534.1 - 8.7e-05 22.6 0.1 0.04 14.0 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Methyltransf_11 PF08241.12 EFX00536.1 - 7.1e-10 39.4 0.0 1.4e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX00536.1 - 3e-08 33.7 0.0 1.2e-06 28.4 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00536.1 - 3.3e-05 24.5 0.0 9.9e-05 23.0 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX00536.1 - 0.00031 20.1 0.0 0.00051 19.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFX00536.1 - 0.00047 20.9 0.0 0.0009 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFX00536.1 - 0.0032 17.4 0.0 0.01 15.7 0.0 1.8 2 1 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_31 PF13847.6 EFX00536.1 - 0.015 15.1 0.0 0.15 11.8 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain eIF3_subunit PF08597.10 EFX00538.1 - 2.4e-70 237.2 16.7 2.7e-70 237.0 16.7 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Rrn6 PF10214.9 EFX00538.1 - 0.036 12.6 7.6 0.051 12.1 7.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DAP PF15228.6 EFX00538.1 - 7.3 7.8 11.4 13 7.0 0.1 2.9 2 1 1 3 3 3 0 Death-associated protein Cytochrom_B561 PF03188.16 EFX00539.1 - 7.9e-05 22.8 10.5 0.00019 21.5 10.5 1.7 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EFX00539.1 - 0.21 11.7 14.7 1.1 9.4 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) MARVEL PF01284.23 EFX00539.1 - 3.3 7.8 11.6 4.4 7.3 0.1 2.6 3 1 0 3 3 3 0 Membrane-associating domain Myb_DNA-binding PF00249.31 EFX00540.1 - 0.0021 18.2 0.3 0.0054 16.9 0.3 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain FRG2 PF15315.6 EFX00540.1 - 0.038 14.2 7.9 0.098 12.9 7.9 1.7 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Ribosomal_L27 PF01016.19 EFX00541.1 - 1.6e-23 82.5 0.1 4e-23 81.2 0.1 1.7 1 0 0 1 1 1 1 Ribosomal L27 protein ECR1_N PF14382.6 EFX00541.1 - 0.049 13.4 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region ABC_tran PF00005.27 EFX00542.1 - 1.2e-31 110.0 0.0 2.6e-31 108.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EFX00542.1 - 1.1e-29 104.0 7.9 1.7e-29 103.4 7.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EFX00542.1 - 1.2e-05 24.9 0.0 2.4e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EFX00542.1 - 0.012 15.8 0.3 0.37 11.1 0.3 2.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.7 EFX00542.1 - 0.027 13.4 0.1 0.25 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain RsgA_GTPase PF03193.16 EFX00542.1 - 0.031 14.2 0.0 0.12 12.2 0.0 1.9 1 1 1 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EFX00542.1 - 0.094 12.5 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain KH_1 PF00013.29 EFX00543.1 - 1.4e-40 137.0 10.6 7e-16 57.8 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EFX00543.1 - 3.1e-10 39.7 10.2 0.0077 16.0 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EFX00543.1 - 3.7e-07 29.9 6.8 0.068 13.1 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EFX00543.1 - 0.00019 21.4 5.9 0.24 11.5 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 EFX00543.1 - 0.0064 16.5 0.0 17 5.5 0.0 3.1 3 0 0 3 3 3 2 KH-like RNA-binding domain Cyto_heme_lyase PF01265.17 EFX00544.1 - 3.4e-119 397.8 0.0 3.8e-119 397.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase NOA36 PF06524.12 EFX00545.1 - 0.012 15.0 1.6 0.017 14.5 1.6 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EFX00545.1 - 4.2 7.8 10.5 8.2 6.9 10.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain AtuA PF07287.11 EFX00546.1 - 1.5e-125 418.6 0.0 1.7e-125 418.4 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA RAI16-like PF10257.9 EFX00547.1 - 2.9e-75 253.4 0.3 4e-75 253.0 0.3 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Katanin_con80 PF13925.6 EFX00547.1 - 0.027 14.5 0.1 5.2 7.1 0.0 2.3 2 0 0 2 2 2 0 con80 domain of Katanin Rdx PF10262.9 EFX00548.1 - 4.7e-33 113.2 0.0 6.7e-33 112.7 0.0 1.2 1 0 0 1 1 1 1 Rdx family zf-TFIIB PF13453.6 EFX00548.1 - 0.034 13.5 0.2 2.1 7.7 0.1 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger ICMT PF04140.14 EFX00549.1 - 2.1e-12 47.3 0.5 9.2e-10 38.8 0.1 2.5 1 1 0 2 2 2 2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFX00549.1 - 3.4e-08 33.8 0.7 2.3e-07 31.1 0.2 2.3 1 1 1 2 2 2 1 Phospholipid methyltransferase G3P_acyltransf PF02660.15 EFX00549.1 - 0.22 11.5 5.8 0.37 10.9 5.8 1.6 1 1 0 1 1 1 0 Glycerol-3-phosphate acyltransferase Iwr1 PF08574.10 EFX00551.1 - 8.1e-15 55.6 10.7 8.1e-15 55.6 10.7 2.9 2 1 1 3 3 3 1 Transcription factor Iwr1 MID_pPIWI_RE PF18157.1 EFX00551.1 - 0.021 15.1 1.9 0.021 15.1 1.9 2.5 3 0 0 3 3 3 0 MID domain of pPIWI_RE Glyco_hydro_44 PF12891.7 EFX00551.1 - 0.11 12.4 3.9 0.039 13.9 0.9 1.8 2 0 0 2 2 2 0 Glycoside hydrolase family 44 STE3 PF02076.15 EFX00552.1 - 4.6e-64 216.4 19.5 5.7e-64 216.1 19.5 1.1 1 0 0 1 1 1 1 Pheromone A receptor 7tm_1 PF00001.21 EFX00552.1 - 0.15 11.3 8.2 0.33 10.2 8.2 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 2OG-FeII_Oxy PF03171.20 EFX00553.1 - 0.00081 19.8 0.0 0.0018 18.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFX00553.1 - 0.0029 18.4 0.0 0.0081 16.9 0.0 1.8 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal F-box-like PF12937.7 EFX00553.1 - 0.02 14.8 0.7 0.11 12.5 0.0 2.7 3 0 0 3 3 3 0 F-box-like Pectate_lyase_3 PF12708.7 EFX00554.1 - 3.1e-101 337.7 11.7 4.9e-86 288.0 6.7 2.6 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EFX00554.1 - 3.1e-08 33.2 2.4 0.0012 18.5 0.1 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase PMG PF05287.12 EFX00554.1 - 0.088 12.8 0.1 0.088 12.8 0.1 2.5 2 0 0 2 2 2 0 PMG protein NosD PF05048.13 EFX00554.1 - 0.16 11.2 10.8 0.027 13.8 4.2 2.7 1 1 2 3 3 3 0 Periplasmic copper-binding protein (NosD) COesterase PF00135.28 EFX00556.1 - 9e-59 199.7 0.0 1e-34 120.3 0.0 2.1 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX00556.1 - 0.17 11.7 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ribosomal_L27A PF00828.19 EFX00557.1 - 6.7e-19 68.8 0.0 1.2e-18 68.0 0.0 1.4 1 1 1 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF3194 PF11419.8 EFX00558.1 - 0.18 12.2 5.0 0.35 11.3 5.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3194) SMC_N PF02463.19 EFX00559.1 - 1.9e-61 207.3 18.7 6.3e-61 205.6 18.7 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFX00559.1 - 1.8e-24 86.3 0.0 6.3e-24 84.5 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EFX00559.1 - 3.6e-20 73.3 0.7 3.6e-20 73.3 0.7 6.6 2 2 4 6 6 6 1 AAA domain AAA_21 PF13304.6 EFX00559.1 - 1.5e-17 64.4 1.5 1.1e-08 35.3 0.3 3.3 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFX00559.1 - 1e-15 58.4 22.8 2.3e-12 47.3 0.0 3.6 2 2 1 3 3 3 2 AAA ATPase domain SbcCD_C PF13558.6 EFX00559.1 - 0.0031 17.7 0.1 0.017 15.3 0.0 2.4 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit PI3K_P85_iSH2 PF16454.5 EFX00559.1 - 0.0035 17.0 8.4 0.0035 17.0 8.4 7.5 3 2 0 5 5 5 2 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain AAA_29 PF13555.6 EFX00559.1 - 0.0049 16.6 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFX00559.1 - 0.86 9.7 3.3 11 6.2 0.4 4.0 3 1 0 3 3 3 0 50S ribosome-binding GTPase Mito_carr PF00153.27 EFX00560.1 - 3.8e-65 215.8 0.7 1.1e-20 73.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein BUD22 PF09073.10 EFX00561.1 - 1.6e-84 284.8 62.4 6.3e-54 183.9 34.8 2.2 1 1 1 2 2 2 2 BUD22 ATP-synt_DE_N PF02823.16 EFX00562.1 - 1.4e-16 60.2 0.0 2.1e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain CspB_prodomain PF18425.1 EFX00562.1 - 0.031 14.3 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Csp protease B prodomain adh_short PF00106.25 EFX00564.1 - 4.1e-17 62.3 0.0 6.9e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX00564.1 - 2.7e-13 50.1 0.0 4.3e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX00564.1 - 0.0098 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 KR domain VPS13_mid_rpt PF16910.5 EFX00564.1 - 0.14 11.6 0.4 0.31 10.4 0.1 1.6 2 0 0 2 2 2 0 Repeating coiled region of VPS13 CAF1A PF12253.8 EFX00565.1 - 8.7e-08 32.2 14.8 1.5e-07 31.5 14.8 1.4 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A SDA1 PF05285.12 EFX00565.1 - 1.8 7.9 5.3 0.4 10.1 2.5 1.3 2 0 0 2 2 2 0 SDA1 Glyco_hydro_30 PF02055.16 EFX00566.1 - 9.6e-35 120.2 0.3 1.7e-34 119.4 0.3 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EFX00566.1 - 5.7e-08 32.9 0.5 1.6e-07 31.4 0.5 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EFX00566.1 - 0.00033 20.0 0.0 0.00053 19.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 DUF2015 PF09435.10 EFX00567.1 - 1.1e-42 144.4 0.0 1.3e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DUF4698 PF15769.5 EFX00568.1 - 0.16 11.0 0.1 0.22 10.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) EcKinase PF02958.20 EFX00569.1 - 4.5e-20 72.2 0.0 5.5e-18 65.3 0.0 2.2 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EFX00569.1 - 1.6e-09 37.2 0.0 2.3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.23 EFX00569.1 - 2.9e-08 34.0 2.1 5.5e-08 33.0 2.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family TPR_2 PF07719.17 EFX00570.1 - 4.4e-07 29.5 6.1 0.00094 19.1 0.1 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX00570.1 - 9.6e-05 22.3 3.9 0.0078 16.4 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFX00570.1 - 0.00013 21.6 3.4 0.16 11.8 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX00570.1 - 0.0004 20.6 2.1 0.1 12.9 0.9 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00570.1 - 0.001 19.7 0.7 0.085 13.5 0.2 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFX00570.1 - 0.001 19.5 1.2 0.016 15.7 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFX00570.1 - 0.024 15.4 1.2 0.78 10.7 0.4 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat IL6 PF00489.17 EFX00570.1 - 0.18 11.4 0.1 0.42 10.1 0.0 1.6 2 0 0 2 2 2 0 Interleukin-6/G-CSF/MGF family Zn_clus PF00172.18 EFX00570.1 - 0.72 10.0 4.9 1.5 9.0 4.9 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_2 PF04059.12 EFX00571.1 - 3.3e-27 94.5 0.2 9.1e-27 93.1 0.2 1.7 2 0 0 2 2 2 1 RNA recognition motif 2 RRM_1 PF00076.22 EFX00571.1 - 0.0046 16.7 0.0 0.066 13.0 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fn3_assoc PF13287.6 EFX00571.1 - 0.077 13.2 0.6 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 Fn3 associated MFS_1 PF07690.16 EFX00572.1 - 9.5e-12 44.5 24.1 1.9e-11 43.5 23.9 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX00572.1 - 6.8e-09 35.1 12.2 1.3e-07 30.9 1.3 2.4 1 1 1 2 2 2 2 Sugar (and other) transporter PRNT PF15174.6 EFX00572.1 - 5.6 7.1 5.7 1 9.4 1.0 2.2 3 0 0 3 3 3 0 Prion-related protein testis-specific GFO_IDH_MocA PF01408.22 EFX00573.1 - 1.2e-21 77.8 0.0 2.1e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFX00573.1 - 1.3e-05 25.2 0.0 2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Aldolase_II PF00596.21 EFX00574.1 - 1.5e-50 171.7 0.1 2e-50 171.4 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain BTB PF00651.31 EFX00575.1 - 3.6e-06 27.2 0.0 1.5e-05 25.2 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain Aa_trans PF01490.18 EFX00577.1 - 1.2e-27 96.7 34.7 1.9e-27 96.0 34.7 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein F_bP_aldolase PF01116.20 EFX00579.1 - 2.2e-81 273.4 0.1 2.4e-81 273.3 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II UAA PF08449.11 EFX00580.1 - 5.3e-11 42.3 14.3 6.7e-11 41.9 14.3 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFX00580.1 - 4.3e-05 23.7 26.9 8.5e-05 22.7 5.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family UPF0370 PF13980.6 EFX00580.1 - 0.099 12.7 0.1 0.99 9.5 0.0 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0370) TPT PF03151.16 EFX00580.1 - 0.53 9.6 15.7 7.6 5.8 15.7 2.3 1 1 0 1 1 1 0 Triose-phosphate Transporter family AAA PF00004.29 EFX00581.1 - 3.8e-41 140.6 0.0 6.3e-41 139.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFX00581.1 - 1.1e-11 44.5 0.2 2.5e-11 43.4 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFX00581.1 - 3e-10 39.7 0.6 5.6e-10 38.9 0.6 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EFX00581.1 - 1.8e-06 28.1 0.0 3.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFX00581.1 - 6.2e-06 26.5 0.2 0.0056 17.0 0.2 2.4 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFX00581.1 - 1.3e-05 24.5 0.0 2.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EFX00581.1 - 5.7e-05 23.1 0.1 0.00021 21.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFX00581.1 - 0.00026 21.4 0.2 0.0028 18.1 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EFX00581.1 - 0.00027 20.7 0.0 0.00052 19.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFX00581.1 - 0.00052 20.6 0.1 0.0012 19.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EFX00581.1 - 0.00053 19.6 0.5 0.0033 17.0 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 EFX00581.1 - 0.0018 18.4 0.1 0.027 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFX00581.1 - 0.0023 18.2 0.4 0.0075 16.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EFX00581.1 - 0.013 15.3 0.0 0.04 13.8 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFX00581.1 - 0.014 15.3 0.1 0.63 10.0 0.1 2.5 1 1 1 2 2 2 0 NACHT domain AAA_14 PF13173.6 EFX00581.1 - 0.017 15.2 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFX00581.1 - 0.019 14.7 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EFX00581.1 - 0.022 14.0 0.1 0.057 12.6 0.1 1.7 1 1 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 EFX00581.1 - 0.029 13.7 0.2 0.62 9.4 0.1 2.4 1 1 1 2 2 2 0 KaiC PhoH PF02562.16 EFX00581.1 - 0.046 13.2 0.8 0.5 9.8 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.22 EFX00581.1 - 0.053 13.9 0.0 0.098 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EFX00581.1 - 0.058 12.8 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EFX00581.1 - 0.061 12.6 0.0 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EFX00581.1 - 0.096 12.2 1.2 0.64 9.6 0.4 2.4 1 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFX00581.1 - 0.1 12.3 1.2 0.29 10.8 0.3 2.4 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EFX00581.1 - 0.16 11.1 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EFX00581.1 - 0.22 11.0 0.1 0.52 9.8 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region TFIIA PF03153.13 EFX00582.1 - 1.8e-05 24.9 24.8 1.8e-05 24.9 24.8 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit TMEM154 PF15102.6 EFX00582.1 - 0.0031 17.4 0.6 0.0031 17.4 0.6 3.2 2 1 1 3 3 2 1 TMEM154 protein family Med15 PF09606.10 EFX00582.1 - 0.0034 16.2 20.4 0.0034 16.2 20.4 2.0 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 EFX00582.1 - 0.0042 16.7 32.0 0.0042 16.7 32.0 1.8 2 0 0 2 2 2 1 Spt20 family eIF-3_zeta PF05091.12 EFX00582.1 - 0.0051 15.9 18.7 0.0079 15.2 18.7 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4366 PF14283.6 EFX00582.1 - 0.017 15.1 3.4 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) EIIBC-GUT_N PF03612.14 EFX00582.1 - 0.061 13.1 10.9 0.034 13.9 7.7 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DDHD PF02862.17 EFX00582.1 - 0.071 13.3 14.6 0.19 11.9 10.3 2.3 2 0 0 2 2 2 0 DDHD domain MecA PF05389.12 EFX00582.1 - 0.075 12.6 4.5 0.15 11.7 4.5 1.5 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) SpoIIP PF07454.11 EFX00582.1 - 0.1 12.0 8.0 0.21 11.0 8.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF572 PF04502.13 EFX00582.1 - 0.11 12.1 15.5 1.2 8.7 12.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) SAPS PF04499.15 EFX00582.1 - 0.17 10.6 8.2 1.7 7.4 6.2 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 EFX00582.1 - 0.18 10.6 17.7 0.23 10.2 13.2 2.2 2 0 0 2 2 2 0 Presenilin Orf78 PF06024.12 EFX00582.1 - 0.19 12.0 6.7 35 4.8 7.6 2.5 2 0 0 2 2 2 0 Orf78 (ac78) SID-1_RNA_chan PF13965.6 EFX00582.1 - 0.2 10.1 0.1 0.28 9.6 0.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4647 PF15504.6 EFX00582.1 - 0.33 10.0 14.6 0.65 9.0 14.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF4746 PF15928.5 EFX00582.1 - 0.5 9.8 3.9 0.85 9.0 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) EOS1 PF12326.8 EFX00582.1 - 0.69 9.8 10.0 0.77 9.7 5.5 2.4 2 0 0 2 2 2 0 N-glycosylation protein DUF4175 PF13779.6 EFX00582.1 - 0.71 7.7 28.5 1.2 6.9 28.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AIF_C PF14721.6 EFX00582.1 - 0.83 10.0 9.2 1.9 8.9 6.6 2.5 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RR_TM4-6 PF06459.12 EFX00582.1 - 0.88 9.3 12.6 0.17 11.7 8.5 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 EFX00582.1 - 0.94 10.1 28.8 0.066 13.9 16.5 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4770 PF15994.5 EFX00582.1 - 1.3 9.2 12.5 2.4 8.4 12.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Connexin PF00029.19 EFX00582.1 - 1.6 8.5 7.2 3.1 7.5 7.2 1.4 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 EFX00582.1 - 2.1 6.1 9.2 3.2 5.6 9.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1676 PF07898.13 EFX00582.1 - 2.6 8.0 4.1 51 3.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DUF4407 PF14362.6 EFX00582.1 - 2.7 7.3 13.8 0.25 10.6 7.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 EFX00582.1 - 3.3 7.7 10.7 0.93 9.5 7.1 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Folate_carrier PF01770.18 EFX00582.1 - 3.8 6.1 6.7 6.4 5.4 6.7 1.2 1 0 0 1 1 1 0 Reduced folate carrier CLN3 PF02487.17 EFX00582.1 - 5.5 5.9 8.2 11 4.9 8.2 1.4 1 0 0 1 1 1 0 CLN3 protein Macoilin PF09726.9 EFX00582.1 - 6.1 5.3 24.6 2.5 6.6 2.7 2.1 2 0 0 2 2 2 0 Macoilin family TMEM51 PF15345.6 EFX00582.1 - 6.6 6.5 18.7 10 5.9 15.2 2.6 2 0 0 2 2 2 0 Transmembrane protein 51 LMBR1 PF04791.16 EFX00582.1 - 6.7 5.5 5.9 29 3.4 6.0 1.7 2 0 0 2 2 2 0 LMBR1-like membrane protein RIC3 PF15361.6 EFX00582.1 - 6.9 7.1 0.0 6.9 7.1 0.0 2.8 2 1 0 2 2 1 0 Resistance to inhibitors of cholinesterase homologue 3 Activator_LAG-3 PF11498.8 EFX00582.1 - 7.6 5.4 40.0 16 4.3 40.0 1.6 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3464 PF11947.8 EFX00582.1 - 7.8 6.2 13.6 17 5.1 12.2 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Suf PF05843.14 EFX00582.1 - 8.7 6.2 22.5 0.58 10.1 16.5 1.9 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Pam16 PF03656.13 EFX00583.1 - 8.5e-34 116.3 0.0 1e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Pam16 MDM31_MDM32 PF08118.11 EFX00585.1 - 6.5e-245 813.8 0.0 7.9e-245 813.5 0.0 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins TraH_2 PF06871.11 EFX00585.1 - 0.018 14.7 0.1 0.032 13.9 0.1 1.3 1 0 0 1 1 1 0 TraH_2 DUF3336 PF11815.8 EFX00587.1 - 1.5e-49 167.3 0.7 2.2e-49 166.7 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EFX00587.1 - 3e-18 66.8 4.8 3.3e-18 66.6 0.1 3.0 3 1 0 3 3 3 1 Patatin-like phospholipase WD40 PF00400.32 EFX00589.1 - 9.6e-44 146.5 15.6 1.7e-06 28.7 0.0 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.8 EFX00589.1 - 2.3e-11 43.1 4.5 0.013 14.2 0.1 4.2 2 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFX00589.1 - 4.4e-09 36.5 0.2 0.36 11.2 0.0 5.9 2 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EFX00589.1 - 7.5e-07 28.9 0.8 3.8e-06 26.6 0.8 2.1 1 1 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFX00589.1 - 4.4e-06 26.5 0.8 1.1e-05 25.2 0.8 1.6 1 0 0 1 1 1 1 F-box-like BBS2_Mid PF14783.6 EFX00589.1 - 0.023 14.7 0.0 3.4 7.8 0.0 3.5 2 1 2 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EFX00589.1 - 0.037 13.4 0.0 1.6 8.0 0.0 2.1 1 1 0 2 2 2 0 WD40-like domain BAG PF02179.16 EFX00590.1 - 4.7e-18 65.4 0.5 4.7e-18 65.4 0.5 1.8 2 0 0 2 2 2 1 BAG domain Coilin_N PF15862.5 EFX00590.1 - 1.3 8.8 4.8 1.3 8.8 0.4 2.4 2 0 0 2 2 2 0 Coilin N-terminus DUF3759 PF12585.8 EFX00591.1 - 7.7e-39 131.6 9.2 9.4e-39 131.4 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DSPc PF00782.20 EFX00592.1 - 2.7e-24 85.5 0.0 9.2e-22 77.3 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFX00592.1 - 0.003 17.1 0.0 0.0047 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF2985 PF11204.8 EFX00594.1 - 3.9e-36 123.0 0.9 6.9e-36 122.3 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) MAP70 PF07058.11 EFX00594.1 - 0.043 12.5 0.8 0.058 12.1 0.8 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Ras PF00071.22 EFX00595.1 - 1.4e-32 112.6 0.0 1.8e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX00595.1 - 3.7e-19 69.1 0.0 5.1e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX00595.1 - 4.1e-10 39.4 0.0 7.8e-10 38.5 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX00595.1 - 8.7e-06 25.8 0.0 1.9e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX00595.1 - 0.00014 21.5 0.0 0.0047 16.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFX00595.1 - 0.0014 18.1 0.0 0.002 17.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFX00595.1 - 0.0057 16.0 0.0 0.0091 15.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFX00595.1 - 0.041 13.0 0.1 4.9 6.2 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit AAA_24 PF13479.6 EFX00595.1 - 0.07 12.8 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFX00595.1 - 0.2 11.4 0.0 0.6 9.8 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Fungal_trans PF04082.18 EFX00596.1 - 4.3e-14 52.2 0.0 1.2e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain 4HBT PF03061.22 EFX00596.1 - 0.00012 22.3 0.8 0.0037 17.6 0.8 2.5 1 1 1 2 2 2 1 Thioesterase superfamily EPL1 PF10513.9 EFX00596.1 - 0.14 12.6 4.9 0.33 11.3 4.9 1.6 1 0 0 1 1 1 0 Enhancer of polycomb-like Zn_clus PF00172.18 EFX00596.1 - 0.2 11.8 11.7 2.2 8.5 11.7 2.2 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EFX00596.1 - 0.83 9.6 19.7 0.016 15.2 11.3 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit UPF0506 PF11703.8 EFX00596.1 - 4.2 7.8 8.6 0.57 10.6 3.0 2.1 2 0 0 2 2 2 0 UPF0506 Presenilin PF01080.17 EFX00596.1 - 7.9 5.1 7.1 14 4.3 7.1 1.3 1 0 0 1 1 1 0 Presenilin Radical_SAM_C PF16199.5 EFX00598.1 - 3.1e-32 110.5 0.0 6.6e-32 109.4 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EFX00598.1 - 1.9e-13 51.1 0.0 7.8e-13 49.1 0.0 2.1 2 1 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EFX00598.1 - 4.4e-10 39.8 0.1 1.4e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX00598.1 - 1.7e-06 27.9 0.1 2.2e-05 24.4 0.0 2.4 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX00598.1 - 0.042 14.3 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ribosomal_L1 PF00687.21 EFX00599.1 - 1.4e-27 96.7 0.0 1.7e-27 96.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF1002 PF06207.11 EFX00599.1 - 0.096 12.2 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) NACHT_N PF17100.5 EFX00600.1 - 1.8e-45 155.5 0.4 1.8e-45 155.5 0.4 2.1 3 0 0 3 3 3 1 N-terminal domain of NWD NACHT-NTPase NACHT PF05729.12 EFX00600.1 - 0.084 12.8 0.0 0.53 10.2 0.0 2.3 2 0 0 2 2 2 0 NACHT domain O-FucT PF10250.9 EFX00601.1 - 1.3e-08 34.9 0.1 1.1e-07 31.9 0.1 2.3 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase LRR_8 PF13855.6 EFX00602.1 - 8.4e-31 105.5 31.5 5e-05 23.0 0.0 9.0 6 3 4 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 EFX00602.1 - 4.2e-26 90.6 31.4 0.00044 20.6 0.6 9.5 5 3 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFX00602.1 - 1.5e-08 34.0 19.0 0.41 10.8 0.0 9.9 12 0 0 12 12 12 3 Leucine Rich repeat LRR_1 PF00560.33 EFX00602.1 - 2.8e-05 24.1 25.1 11 7.0 0.0 11.0 11 1 0 11 11 11 2 Leucine Rich Repeat LRR_9 PF14580.6 EFX00602.1 - 0.0048 16.4 9.4 0.59 9.6 0.1 4.3 2 2 2 4 4 4 3 Leucine-rich repeat FMO-like PF00743.19 EFX00603.1 - 1.2e-13 50.4 0.0 3.1e-13 49.0 0.0 1.6 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFX00603.1 - 2.8e-12 46.5 0.0 1.1e-10 41.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX00603.1 - 3.6e-10 39.9 0.1 2.5e-09 37.2 0.0 2.5 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFX00603.1 - 3e-07 29.9 0.1 5.2e-06 25.8 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFX00603.1 - 4.3e-07 29.5 1.0 4.9e-06 26.0 1.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX00603.1 - 0.00014 21.6 10.0 0.079 12.5 0.5 3.2 1 1 2 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX00603.1 - 0.0097 15.9 4.9 0.5 10.3 0.0 4.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.17 EFX00603.1 - 0.01 15.1 0.2 0.026 13.7 0.0 1.7 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 EFX00603.1 - 0.013 16.0 0.6 5 7.7 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF1902 PF08972.11 EFX00603.1 - 0.24 11.4 2.7 0.55 10.3 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) LRR_4 PF12799.7 EFX00604.1 - 1.4e-12 47.6 6.1 8.6e-05 22.8 0.2 3.7 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFX00604.1 - 1.9e-11 43.5 10.0 1.6e-06 27.8 3.6 3.4 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFX00604.1 - 0.00012 22.2 6.3 25 5.9 0.0 5.8 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.6 EFX00604.1 - 0.0038 16.8 0.3 0.0078 15.7 0.3 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 EFX00604.1 - 0.006 16.5 13.0 0.74 10.0 0.1 5.1 5 0 0 5 5 5 2 Leucine Rich repeat Fungal_trans PF04082.18 EFX00605.1 - 1.5e-13 50.4 0.0 3.1e-13 49.4 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX00605.1 - 2 8.6 15.1 0.62 10.2 11.9 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.29 EFX00607.1 - 2.1e-31 109.0 0.0 3.3e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX00607.1 - 9e-18 64.6 0.0 2.6e-17 63.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX00607.1 - 0.0045 17.0 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1529 PF07485.11 EFX00607.1 - 0.073 13.0 0.0 2 8.4 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1259) PBD PF00786.28 EFX00608.1 - 0.0093 16.3 0.0 0.029 14.7 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain FAD_binding_3 PF01494.19 EFX00609.1 - 1.2e-17 64.2 1.8 3.3e-17 62.7 1.8 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EFX00609.1 - 0.081 12.2 0.2 0.25 10.5 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase mRNA_cap_enzyme PF01331.19 EFX00610.1 - 6.5e-51 172.9 0.0 8.8e-51 172.5 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EFX00610.1 - 1.6e-30 105.9 0.0 2.9e-30 105.1 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EFX00610.1 - 1.5e-07 31.2 0.1 2.8e-05 23.9 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EFX00610.1 - 0.0092 16.3 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA ligase Methyltransf_23 PF13489.6 EFX00611.1 - 3.9e-15 56.1 0.0 6.7e-15 55.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00611.1 - 4.1e-09 37.0 0.0 1e-08 35.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00611.1 - 9.7e-09 35.2 0.0 0.00031 20.6 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00611.1 - 4.6e-06 27.3 0.0 9e-05 23.2 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00611.1 - 3.1e-05 24.5 0.0 7.1e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX00611.1 - 0.001 18.7 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EFX00611.1 - 0.067 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EFX00611.1 - 0.16 11.4 0.0 0.34 10.4 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EFX00611.1 - 0.23 11.6 0.0 0.36 10.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase tRNA-synt_1b PF00579.25 EFX00612.1 - 7.2e-64 215.9 0.0 1.2e-63 215.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.22 EFX00612.1 - 5.4e-26 90.7 0.0 1.1e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF5561 PF17716.1 EFX00612.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5561) Ank_5 PF13857.6 EFX00613.1 - 9.5e-07 29.0 0.1 1.8e-05 24.9 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX00613.1 - 0.00028 21.4 0.1 0.0016 19.0 0.1 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX00613.1 - 0.0069 16.9 0.1 0.052 14.2 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX00613.1 - 0.065 13.8 0.5 0.4 11.4 0.4 2.3 3 0 0 3 3 3 0 Ankyrin repeat DUF1583 PF07622.11 EFX00613.1 - 0.07 11.9 0.0 0.079 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) Methyltransf_23 PF13489.6 EFX00614.1 - 2.9e-19 69.5 0.0 4.3e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX00614.1 - 1.5e-11 44.3 0.0 2e-10 40.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00614.1 - 8.9e-11 42.4 0.0 2.2e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00614.1 - 1e-06 29.3 0.0 2.4e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00614.1 - 4.7e-05 24.1 0.0 0.00041 21.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EFX00614.1 - 0.0084 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.14 EFX00614.1 - 0.016 14.8 0.0 0.061 12.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX00614.1 - 0.038 13.4 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 EFX00614.1 - 0.048 13.0 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF4602 PF15375.6 EFX00616.1 - 0.0044 17.3 0.0 0.0044 17.3 0.0 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF4602) DUF1970 PF09301.10 EFX00616.1 - 0.11 12.7 0.3 0.39 11.0 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1970) Steroid_dh PF02544.16 EFX00617.1 - 1.3e-14 54.5 3.0 3.7e-14 52.9 3.0 1.8 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase bMG5 PF17972.1 EFX00618.1 - 0.15 12.4 0.4 10 6.5 0.0 2.7 3 0 0 3 3 3 0 Bacterial Alpha-2-macroglobulin MG5 domain NRDE-2 PF08424.10 EFX00619.1 - 7.6e-85 284.9 0.0 2.1e-84 283.4 0.0 1.8 2 0 0 2 2 2 1 NRDE-2, necessary for RNA interference Phage_holin_3_6 PF07332.11 EFX00620.1 - 3 7.9 7.0 0.19 11.8 1.9 1.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Epimerase PF01370.21 EFX00621.1 - 8.9e-20 71.2 0.0 1.2e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX00621.1 - 3.2e-13 49.8 0.0 4.9e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFX00621.1 - 7.5e-09 35.1 0.0 1.1e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EFX00621.1 - 1.1e-06 27.8 0.0 2.4e-06 26.8 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFX00621.1 - 0.00044 19.5 0.0 0.41 9.8 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EFX00621.1 - 0.016 14.6 0.0 0.31 10.4 0.0 2.8 2 1 0 2 2 2 0 short chain dehydrogenase Ldh_1_N PF00056.23 EFX00621.1 - 0.047 13.8 0.0 0.099 12.7 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFX00621.1 - 0.054 12.6 0.0 2.4 7.2 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFX00621.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding ADH_N PF08240.12 EFX00622.1 - 4.4e-24 84.5 1.0 7.9e-24 83.6 1.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX00622.1 - 8.1e-17 61.4 1.1 1.3e-16 60.8 1.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX00622.1 - 5.2e-06 27.5 0.0 9.3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX00622.1 - 0.00051 19.4 2.7 0.00087 18.6 2.7 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EFX00622.1 - 0.0026 17.2 0.2 0.0039 16.6 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EFX00622.1 - 0.21 11.5 3.4 0.068 13.0 0.6 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EFX00622.1 - 1.1 9.3 3.7 8 6.5 1.0 2.4 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain adh_short_C2 PF13561.6 EFX00623.1 - 6e-33 114.4 3.5 1.8e-32 112.8 3.5 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX00623.1 - 5.9e-24 84.6 0.8 8.2e-24 84.1 0.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX00623.1 - 3.1e-07 30.5 1.9 6.6e-07 29.4 0.7 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EFX00623.1 - 0.0095 15.4 0.4 0.047 13.1 0.4 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 EFX00624.1 - 2.9e-10 40.2 0.0 6.9e-08 32.5 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX00624.1 - 2.5e-08 34.5 0.0 1.1e-07 32.4 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00624.1 - 4.8e-05 24.0 0.0 0.001 19.7 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX00624.1 - 0.00016 21.1 0.0 0.00096 18.5 0.0 1.9 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFX00624.1 - 0.00062 20.5 0.0 0.0017 19.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFX00624.1 - 0.016 15.1 0.0 0.055 13.3 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase MTS PF05175.14 EFX00624.1 - 0.054 13.1 0.0 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain DUF2625 PF10946.8 EFX00624.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2625 Methyltransf_31 PF13847.6 EFX00624.1 - 0.17 11.7 0.0 0.44 10.3 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase domain LigB PF02900.18 EFX00625.1 - 2.2e-31 108.9 0.0 3.3e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase PALP PF00291.25 EFX00625.1 - 0.061 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Pribosyltran PF00156.27 EFX00626.1 - 2.3e-06 27.2 0.0 3.5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Bactofilin PF04519.13 EFX00627.1 - 4.5e-07 30.1 1.1 1.7e-06 28.2 0.7 1.9 1 1 0 1 1 1 1 Polymer-forming cytoskeletal FapA PF03961.13 EFX00627.1 - 0.0011 17.7 5.1 0.0077 14.9 0.7 2.0 1 1 1 2 2 2 2 Flagellar Assembly Protein A MinC_C PF03775.16 EFX00627.1 - 0.14 12.2 0.8 15 5.7 0.1 2.6 1 1 1 2 2 2 0 Septum formation inhibitor MinC, C-terminal domain AMP-binding PF00501.28 EFX00628.1 - 1.4e-66 224.9 0.1 1.8e-66 224.5 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX00628.1 - 5.3e-18 65.8 0.2 1.5e-17 64.3 0.2 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SAM_2 PF07647.17 EFX00630.1 - 1.2e-08 34.9 0.1 3.3e-08 33.5 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_8 PF13181.6 EFX00630.1 - 4.4e-08 32.7 18.5 0.33 11.3 0.4 9.3 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_20 PF14561.6 EFX00630.1 - 1.4e-07 31.8 16.0 0.005 17.2 0.2 6.5 6 1 0 6 6 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFX00630.1 - 3.3e-05 23.5 15.5 0.022 14.5 0.0 6.7 6 1 1 7 7 7 2 TPR repeat TPR_7 PF13176.6 EFX00630.1 - 0.00016 21.5 10.4 0.18 11.9 0.4 6.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00630.1 - 0.00035 21.1 55.2 0.0021 18.7 0.4 9.6 8 1 0 8 8 7 4 Tetratricopeptide repeat SAM_1 PF00536.30 EFX00630.1 - 0.00062 20.2 0.2 0.0015 18.9 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_1 PF00515.28 EFX00630.1 - 0.00063 19.4 31.3 0.44 10.4 0.0 8.9 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00630.1 - 0.0086 16.1 44.2 1.2 9.4 0.0 10.7 12 0 0 12 12 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX00630.1 - 0.017 15.3 0.0 0.017 15.3 0.0 7.3 7 1 1 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFX00630.1 - 0.065 13.6 6.4 0.68 10.4 0.0 5.4 7 0 0 7 7 5 0 Tetratricopeptide repeat IGR PF09597.10 EFX00630.1 - 0.12 12.5 1.9 0.16 12.1 0.1 2.2 2 0 0 2 2 1 0 IGR protein motif TPR_14 PF13428.6 EFX00630.1 - 0.15 13.0 57.2 0.16 12.9 0.3 12.1 12 1 0 12 12 10 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EFX00630.1 - 0.22 12.0 5.2 5 7.6 0.1 3.9 4 0 0 4 4 3 0 Alkyl sulfatase dimerisation TPR_19 PF14559.6 EFX00630.1 - 9.4 6.8 38.5 3.4 8.2 0.2 8.1 9 1 0 9 9 8 0 Tetratricopeptide repeat SNF5 PF04855.12 EFX00631.1 - 6.8e-66 222.4 0.1 6.8e-66 222.4 0.1 3.2 3 1 0 3 3 3 1 SNF5 / SMARCB1 / INI1 TFIIA PF03153.13 EFX00631.1 - 1.7 8.5 29.7 2.5 8.0 22.1 2.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit UAA PF08449.11 EFX00632.1 - 7.8e-39 133.7 5.8 1.1e-38 133.1 5.8 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFX00632.1 - 5e-08 33.2 19.1 3e-07 30.7 4.4 2.5 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EFX00632.1 - 1.8e-07 30.6 4.2 0.0014 17.9 0.5 2.5 3 0 0 3 3 3 2 Nucleotide-sugar transporter CRT-like PF08627.10 EFX00632.1 - 0.00019 20.5 5.1 0.057 12.4 0.1 2.6 3 0 0 3 3 3 2 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 EFX00632.1 - 0.084 12.2 10.2 0.78 9.0 1.9 2.4 2 0 0 2 2 2 0 Triose-phosphate Transporter family AAA PF00004.29 EFX00633.1 - 1.3e-39 135.7 0.0 2.5e-39 134.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFX00633.1 - 5.8e-19 67.8 0.1 1.2e-18 66.8 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFX00633.1 - 1.4e-06 28.0 0.0 2.9e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFX00633.1 - 2.9e-05 24.1 0.0 0.00014 21.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFX00633.1 - 0.00011 22.7 1.4 0.022 15.2 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EFX00633.1 - 0.00039 20.2 0.0 0.00093 19.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFX00633.1 - 0.00093 19.5 1.1 0.081 13.2 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_2 PF07724.14 EFX00633.1 - 0.0026 17.9 0.0 0.015 15.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 EFX00633.1 - 0.006 16.1 0.2 0.082 12.4 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 EFX00633.1 - 0.0084 15.5 0.0 0.021 14.2 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFX00633.1 - 0.016 15.4 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFX00633.1 - 0.025 13.8 1.5 0.029 13.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EFX00633.1 - 0.079 12.7 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 EFX00633.1 - 0.09 12.5 3.9 0.5 10.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFX00633.1 - 0.12 11.8 0.0 0.32 10.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region RPN2_C PF18004.1 EFX00633.1 - 2.7 7.9 5.4 5.9 6.8 5.4 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nnf1 PF03980.14 EFX00633.1 - 3.4 8.1 8.9 1.8 9.0 5.3 2.4 3 0 0 3 3 2 0 Nnf1 Glutaredoxin PF00462.24 EFX00635.1 - 9.9e-21 73.7 0.0 1.4e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 EFX00635.1 - 0.0038 17.7 0.1 0.0063 17.0 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 EFX00635.1 - 0.0039 17.0 0.0 0.0044 16.9 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein DUF836 PF05768.14 EFX00635.1 - 0.012 16.0 0.0 0.016 15.6 0.0 1.4 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 EFX00635.1 - 0.015 15.1 0.1 0.048 13.4 0.2 1.7 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin PF00085.20 EFX00635.1 - 0.017 15.1 0.0 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_4 PF13462.6 EFX00635.1 - 0.028 14.6 0.3 0.16 12.1 0.1 1.9 1 1 1 2 2 2 0 Thioredoxin GST_N_3 PF13417.6 EFX00635.1 - 0.049 14.1 0.0 0.062 13.7 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Thioredoxin_7 PF13899.6 EFX00635.1 - 0.15 12.2 0.1 0.24 11.6 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like CBF PF03914.17 EFX00636.1 - 2.7e-26 92.6 0.7 4.4e-26 91.9 0.1 1.7 2 0 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.11 EFX00636.1 - 3e-25 88.5 0.0 1.3e-24 86.5 0.0 2.1 2 0 0 2 2 2 1 Nucleolar complex-associated protein F-box-like PF12937.7 EFX00637.1 - 0.00032 20.5 0.0 0.00078 19.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX00637.1 - 0.0039 17.0 0.1 0.012 15.4 0.1 1.8 1 0 0 1 1 1 1 F-box domain RNA_POL_M_15KD PF02150.16 EFX00638.1 - 3.6e-11 42.8 1.7 3.6e-11 42.8 1.7 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 EFX00638.1 - 0.46 10.9 12.4 0.93 9.9 0.1 3.3 2 2 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme zf-CHY PF05495.12 EFX00638.1 - 0.81 10.2 10.2 6 7.4 0.9 2.4 2 0 0 2 2 2 0 CHY zinc finger zf-H2C2_5 PF13909.6 EFX00639.1 - 0.0003 20.5 16.2 0.0012 18.5 3.3 3.7 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 EFX00639.1 - 0.00065 20.0 3.0 0.00065 20.0 3.0 4.8 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX00639.1 - 0.0024 18.6 1.5 0.0024 18.6 1.5 4.8 4 0 0 4 4 4 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX00639.1 - 0.017 15.5 3.1 0.017 15.5 3.1 3.4 5 0 0 5 5 5 0 Zinc-finger double domain DNA_pol_B_N PF18094.1 EFX00639.1 - 0.11 13.0 0.2 0.34 11.5 0.2 1.8 1 0 0 1 1 1 0 DNA polymerase beta N-terminal domain TRAF6_Z2 PF18048.1 EFX00639.1 - 0.12 12.5 5.9 0.81 9.8 3.2 2.8 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 DUF2076 PF09849.9 EFX00639.1 - 5.2 7.0 13.6 0.62 10.1 3.3 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) Prok-RING_1 PF14446.6 EFX00639.1 - 8.4 6.4 8.3 1.3 9.0 3.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Bac_surface_Ag PF01103.23 EFX00640.1 - 2.2e-35 122.7 0.0 2.9e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Surface antigen Phospho_p8 PF10195.9 EFX00641.1 - 1.7 9.2 4.1 10 6.7 0.3 2.4 2 0 0 2 2 2 0 DNA-binding nuclear phosphoprotein p8 CorA PF01544.18 EFX00643.1 - 1.1e-06 28.3 2.5 1.4e-06 27.8 2.4 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CDH PF02611.15 EFX00643.1 - 0.038 13.6 0.1 0.063 12.9 0.1 1.2 1 0 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase AnmK PF03702.14 EFX00643.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase CRIM PF16978.5 EFX00644.1 - 1.9e-48 164.2 0.0 3.9e-48 163.2 0.0 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EFX00644.1 - 6.2e-24 84.4 0.0 1.2e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PRCC PF10253.9 EFX00644.1 - 1e-22 82.0 14.9 1e-22 82.0 14.9 3.7 3 1 0 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting TUG-UBL1 PF11470.8 EFX00644.1 - 0.026 14.7 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 TUG ubiquitin-like domain RBD PF02196.15 EFX00644.1 - 0.049 13.7 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain Ish1 PF10281.9 EFX00645.1 - 1e-88 291.3 14.7 1.9e-16 60.1 0.2 8.7 8 0 0 8 8 8 8 Putative stress-responsive nuclear envelope protein SAP PF02037.27 EFX00645.1 - 1.2e-12 47.3 0.0 0.21 11.4 0.0 8.7 11 0 0 11 11 11 4 SAP domain HeH PF12949.7 EFX00645.1 - 7.8e-07 28.7 0.0 1.4 8.7 0.0 5.8 6 0 0 6 6 6 2 HeH/LEM domain Slx4 PF09494.10 EFX00645.1 - 1.6e-06 28.0 1.8 2.3 8.2 0.0 6.1 6 0 0 6 6 6 2 Slx4 endonuclease EloA-BP1 PF15870.5 EFX00645.1 - 0.013 15.7 0.1 0.51 10.6 0.0 2.9 2 1 1 3 3 3 0 ElonginA binding-protein 1 LEM PF03020.15 EFX00645.1 - 0.048 13.2 0.0 10 5.8 0.0 3.5 4 0 0 4 4 4 0 LEM domain SAM_2 PF07647.17 EFX00645.1 - 0.27 11.4 2.0 1.2 9.3 0.1 3.1 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) ApoLp-III PF07464.11 EFX00645.1 - 1.5 8.9 3.6 9.5 6.3 0.3 3.3 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.7 EFX00645.1 - 3.5 8.2 12.3 17 6.1 0.7 4.8 4 1 0 4 4 4 0 YtxH-like protein Apolipoprotein PF01442.18 EFX00645.1 - 7.7 6.3 11.3 15 5.4 0.4 3.6 4 1 0 4 4 4 0 Apolipoprotein A1/A4/E domain Fungal_trans PF04082.18 EFX00646.1 - 8.4e-11 41.4 0.1 1.5e-10 40.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CCDC14 PF15254.6 EFX00647.1 - 0.2 10.3 1.1 0.21 10.2 1.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 AA_permease_2 PF13520.6 EFX00648.1 - 8.4e-47 159.9 29.7 1e-46 159.6 29.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX00648.1 - 8e-11 41.2 26.6 1e-10 40.9 26.6 1.1 1 0 0 1 1 1 1 Amino acid permease DEAD PF00270.29 EFX00649.1 - 5.7e-44 150.0 0.0 1.2e-43 148.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2183 PF09949.9 EFX00649.1 - 4.3e-33 113.6 0.0 1.2e-32 112.2 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Helicase_C PF00271.31 EFX00649.1 - 6.6e-27 94.1 0.1 2.1e-26 92.4 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX00649.1 - 0.0069 16.4 0.4 0.069 13.2 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2724 PF10893.8 EFX00649.1 - 0.11 12.4 0.3 14 5.6 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2724) Ribosomal_L28e PF01778.17 EFX00650.1 - 1.1e-32 113.2 0.1 1.8e-32 112.5 0.0 1.4 1 1 1 2 2 2 1 Ribosomal L28e protein family adh_short PF00106.25 EFX00652.1 - 2.9e-27 95.4 0.1 9.4e-15 54.6 0.2 2.9 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX00652.1 - 2.1e-19 70.0 0.0 7.1e-11 42.1 0.1 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX00652.1 - 1.5e-09 38.1 0.1 1.9e-06 27.9 0.2 2.3 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EFX00652.1 - 7.1e-05 22.4 0.6 0.00037 20.0 0.6 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFX00652.1 - 0.0016 18.1 0.2 0.0081 15.7 0.3 1.9 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EFX00652.1 - 0.0021 17.3 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFX00652.1 - 0.02 14.0 0.1 0.051 12.7 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFX00652.1 - 0.023 14.6 2.6 0.041 13.8 1.0 2.2 3 0 0 3 3 3 0 NAD(P)H-binding GGDEF_2 PF17853.1 EFX00652.1 - 0.07 13.4 0.3 0.21 11.8 0.1 1.9 2 0 0 2 2 2 0 GGDEF-like domain Eapp_C PF10238.9 EFX00652.1 - 0.094 12.8 0.2 0.094 12.8 0.2 1.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein F420_oxidored PF03807.17 EFX00652.1 - 0.14 12.8 0.2 0.33 11.6 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EFX00652.1 - 0.14 11.5 0.4 0.3 10.5 0.1 1.7 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase DNApol_Exo PF18136.1 EFX00652.1 - 0.35 10.0 1.5 0.56 9.3 1.5 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Mg_trans_NIPA PF05653.14 EFX00654.1 - 1e-62 212.0 11.9 2.2e-61 207.6 5.9 2.5 3 0 0 3 3 3 2 Magnesium transporter NIPA SLC35F PF06027.12 EFX00654.1 - 0.0094 15.5 2.0 0.28 10.7 0.0 2.3 2 0 0 2 2 2 1 Solute carrier family 35 EamA PF00892.20 EFX00654.1 - 0.019 15.1 24.8 0.037 14.2 2.1 4.2 3 1 0 3 3 3 0 EamA-like transporter family Mucin PF01456.17 EFX00654.1 - 0.044 13.8 9.5 0.13 12.3 9.5 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein SARAF PF06682.12 EFX00654.1 - 0.07 12.8 4.4 0.13 11.8 4.4 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF1461 PF07314.11 EFX00654.1 - 1.3 8.9 4.6 0.46 10.4 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) TssN PF17555.2 EFX00654.1 - 5.7 6.2 7.5 8.7 5.6 7.5 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN Ribosomal_S8e PF01201.22 EFX00655.1 - 8.7e-42 142.5 1.6 1.5e-41 141.7 1.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e Cofilin_ADF PF00241.20 EFX00655.1 - 1.1e-27 96.3 0.0 5.7e-14 52.0 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Aminotran_1_2 PF00155.21 EFX00656.1 - 9.5e-77 258.6 0.0 1.3e-76 258.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFX00656.1 - 0.00039 19.1 0.0 0.00065 18.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFX00656.1 - 0.0024 16.9 0.0 0.0045 16.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFX00656.1 - 0.035 13.4 0.5 0.062 12.6 0.5 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3405 PF11885.8 EFX00656.1 - 0.17 10.4 0.4 0.25 9.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) HALZ PF02183.18 EFX00657.1 - 0.062 13.5 4.2 1.7 8.9 0.2 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper zf-Mss51 PF13824.6 EFX00658.1 - 5.5e-31 106.4 5.4 1.1e-30 105.5 5.4 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EFX00658.1 - 0.002 18.2 1.8 0.0026 17.8 0.1 1.9 2 0 0 2 2 2 1 MYND finger DUF1610 PF07754.11 EFX00658.1 - 0.56 10.2 3.6 0.3 11.1 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) p450 PF00067.22 EFX00659.1 - 1.3e-70 238.5 0.0 1.7e-70 238.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M99_m PF17130.4 EFX00659.1 - 0.12 12.4 0.0 0.53 10.3 0.0 2.1 2 0 0 2 2 2 0 beta-barrel domain of carboxypeptidase M99 2-Hacid_dh_C PF02826.19 EFX00660.1 - 6.2e-34 116.9 0.0 1.5e-24 86.3 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sugar_tr PF00083.24 EFX00660.1 - 2.7e-15 56.2 1.9 5.2e-07 28.9 0.1 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFX00660.1 - 0.0041 16.1 5.7 0.12 11.3 0.2 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4045 PF13254.6 EFX00662.1 - 2.4e-75 254.7 32.9 1.2e-44 153.7 25.3 6.3 4 2 2 7 7 7 2 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EFX00662.1 - 1.4e-07 31.3 0.1 0.0022 17.8 0.0 2.9 3 0 0 3 3 3 2 Gelsolin repeat zf-CCHC PF00098.23 EFX00664.1 - 0.0021 18.0 3.9 0.0034 17.4 3.9 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 EFX00664.1 - 0.48 10.2 1.5 1.1 9.1 1.5 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EFX00664.1 - 1.2 9.0 4.4 2.4 8.1 4.4 1.3 1 0 0 1 1 1 0 Zinc knuckle Chalcone_2 PF16035.5 EFX00665.1 - 6.4e-76 254.7 0.0 8.4e-76 254.3 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EFX00665.1 - 0.028 14.5 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 Chalcone isomerase-like Erf4 PF10256.9 EFX00666.1 - 3.3e-37 127.1 0.0 4.9e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Axin_b-cat_bind PF08833.10 EFX00666.1 - 0.66 10.1 3.1 1.1 9.4 1.1 2.5 2 0 0 2 2 2 0 Axin beta-catenin binding domain adh_short PF00106.25 EFX00667.1 - 2.6e-37 128.2 0.1 4.1e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX00667.1 - 6.7e-24 84.7 0.0 1e-23 84.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX00667.1 - 6e-10 39.3 3.7 3.5e-05 23.8 0.0 2.6 3 0 0 3 3 3 2 KR domain Epimerase PF01370.21 EFX00667.1 - 4.4e-06 26.3 0.1 1.2e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX00667.1 - 0.0066 15.5 0.0 0.0092 15.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFX00667.1 - 0.01 15.8 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFX00667.1 - 0.029 13.4 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Pyr_redox PF00070.27 EFX00667.1 - 0.13 12.8 0.8 1.5 9.4 0.6 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GDP_Man_Dehyd PF16363.5 EFX00667.1 - 0.15 11.4 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFX00667.1 - 0.25 10.5 0.3 0.36 9.9 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Hydrolase_6 PF13344.6 EFX00668.1 - 3.8e-27 94.4 0.0 8.4e-27 93.2 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX00668.1 - 9e-16 57.7 0.5 1.8e-14 53.6 0.1 2.6 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EFX00668.1 - 2.5e-09 37.7 0.1 0.0037 17.6 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFX00668.1 - 0.00034 20.8 0.0 0.074 13.1 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Peptidase_M13_N PF05649.13 EFX00669.1 - 2.6e-84 284.1 0.0 3.3e-84 283.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EFX00669.1 - 2.7e-59 200.2 0.0 4.5e-59 199.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 zf-HC5HC2H_2 PF13832.6 EFX00670.1 - 9.8e-33 112.6 7.1 9.8e-33 112.6 7.1 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 EFX00670.1 - 1.3e-27 97.1 0.0 1.2e-26 94.0 0.0 2.4 1 1 0 1 1 1 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 EFX00670.1 - 4.9e-25 87.6 6.4 4.9e-25 87.6 6.4 2.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EFX00670.1 - 1.8e-14 53.0 1.7 1.8e-14 53.0 1.7 2.0 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EFX00670.1 - 1e-08 34.9 9.4 1e-08 34.9 9.4 2.8 3 0 0 3 3 3 2 PHD-finger zf-PHD-like PF15446.6 EFX00670.1 - 5.3 6.6 13.1 0.023 14.3 1.5 2.3 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain CoA_binding PF02629.19 EFX00671.1 - 2.1e-28 98.8 3.7 2.3e-28 98.7 0.8 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EFX00671.1 - 1.7e-23 83.1 0.3 2.6e-23 82.6 0.3 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EFX00671.1 - 6.5e-09 35.7 0.1 1.3e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EFX00671.1 - 0.00023 21.6 0.0 0.00059 20.3 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain SGL PF08450.12 EFX00672.1 - 7.6e-60 202.5 0.0 1e-59 202.1 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 EFX00672.1 - 0.018 15.0 0.5 0.046 13.7 0.0 1.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Amidohydro_1 PF01979.20 EFX00673.1 - 3.2e-22 79.3 0.0 2.2e-21 76.6 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX00673.1 - 2e-12 47.3 2.9 1.6e-05 24.6 1.0 2.9 2 1 1 3 3 3 2 Amidohydrolase family Urease_alpha PF00449.20 EFX00673.1 - 0.0066 16.8 0.2 0.02 15.2 0.3 1.8 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Pkinase PF00069.25 EFX00674.1 - 7.6e-72 241.8 0.0 9.2e-72 241.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00674.1 - 1.5e-37 129.3 0.0 2e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00674.1 - 3e-07 30.1 0.0 4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Nucleo_P87 PF07267.11 EFX00674.1 - 0.48 9.2 3.2 0.65 8.8 3.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TFIIA PF03153.13 EFX00674.1 - 2.3 8.1 14.3 3 7.7 14.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2046 PF09755.9 EFX00675.1 - 0.0034 16.7 0.0 0.049 12.8 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) Atg14 PF10186.9 EFX00675.1 - 0.28 10.2 4.7 0.075 12.1 1.4 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 EFX00675.1 - 0.35 11.3 9.0 0.081 13.4 2.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Pox_A_type_inc PF04508.12 EFX00675.1 - 0.82 9.6 2.9 1.8 8.6 2.9 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DivIC PF04977.15 EFX00675.1 - 4.4 7.2 4.8 1.8 8.4 0.7 2.2 2 0 0 2 2 2 0 Septum formation initiator GCD14 PF08704.10 EFX00676.1 - 7.5e-65 219.0 0.0 2.6e-61 207.5 0.0 2.1 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit DUF3425 PF11905.8 EFX00677.1 - 5.4e-11 42.6 0.5 7.3e-09 35.7 0.0 3.7 4 1 0 4 4 4 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EFX00677.1 - 5.2 7.2 9.1 2.6 8.2 2.8 2.3 2 0 0 2 2 2 0 bZIP transcription factor Hap4_Hap_bind PF10297.9 EFX00678.1 - 6.9e-09 35.5 6.9 1.5e-08 34.4 6.9 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 EFX00678.1 - 0.0008 19.5 8.6 0.0008 19.5 8.6 2.7 2 1 1 3 3 3 1 bZIP transcription factor HAUS6_N PF14661.6 EFX00678.1 - 0.058 13.0 2.3 0.094 12.3 2.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4482 PF14818.6 EFX00678.1 - 0.07 14.0 4.6 0.12 13.3 2.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Fmp27_WPPW PF10359.9 EFX00678.1 - 0.083 11.7 3.5 0.12 11.2 3.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain dsrm PF00035.26 EFX00678.1 - 0.087 13.5 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif bZIP_2 PF07716.15 EFX00678.1 - 0.11 12.6 14.4 1 9.5 8.9 2.6 1 1 1 2 2 2 0 Basic region leucine zipper CLZ PF16526.5 EFX00678.1 - 0.16 12.3 2.1 1.8 9.0 3.8 1.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PspB PF06667.12 EFX00678.1 - 0.18 11.9 2.2 0.3 11.2 1.5 1.7 1 1 1 2 2 2 0 Phage shock protein B Spc24 PF08286.11 EFX00678.1 - 0.22 11.8 0.6 0.46 10.8 0.6 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 MFS_1 PF07690.16 EFX00679.1 - 6.2e-34 117.5 30.1 7.5e-34 117.2 30.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFX00679.1 - 3.9e-05 23.1 4.7 3.9e-05 23.1 4.7 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Syndecan PF01034.20 EFX00679.1 - 0.0086 16.0 0.8 0.094 12.6 0.0 2.7 2 0 0 2 2 2 1 Syndecan domain Sugar_tr PF00083.24 EFX00680.1 - 4.1e-102 342.4 19.7 9.7e-101 337.8 19.7 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX00680.1 - 3e-20 72.4 48.0 7.6e-17 61.3 17.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Yip1 PF04893.17 EFX00681.1 - 2.5e-05 24.1 14.6 0.00058 19.6 6.1 2.7 2 1 1 3 3 3 2 Yip1 domain ADH_zinc_N PF00107.26 EFX00682.1 - 2.2e-11 43.9 0.1 4.8e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX00682.1 - 8.6e-06 25.6 0.4 6.7e-05 22.7 0.2 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFX00682.1 - 0.0089 17.1 0.2 0.031 15.3 0.2 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase RRM_1 PF00076.22 EFX00684.1 - 7.2e-08 32.1 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFX00684.1 - 4.6e-06 26.5 0.0 7.9e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFX00684.1 - 0.0044 16.8 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif DsrC PF04358.13 EFX00684.1 - 0.15 12.6 0.1 0.35 11.4 0.1 1.6 1 0 0 1 1 1 0 DsrC like protein DUF1996 PF09362.10 EFX00685.1 - 3.4e-62 210.5 0.2 3.4e-62 210.5 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1996) PHD PF00628.29 EFX00686.1 - 8.7e-09 35.1 3.2 1.5e-08 34.4 3.2 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.7 EFX00686.1 - 0.009 16.6 0.0 0.009 16.6 0.0 2.6 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PRTP PF01366.18 EFX00686.1 - 0.07 11.2 1.9 0.15 10.1 1.9 1.4 1 0 0 1 1 1 0 Herpesvirus processing and transport protein TFB6 PF17110.5 EFX00686.1 - 0.11 12.2 4.0 0.29 10.8 4.0 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH TFIIA PF03153.13 EFX00686.1 - 0.2 11.6 26.6 0.21 11.6 7.3 3.3 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF2785 PF10978.8 EFX00686.1 - 0.37 10.6 2.5 0.78 9.5 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) PIEZO PF15917.5 EFX00686.1 - 0.44 10.0 11.5 0.87 9.0 3.2 3.4 4 0 0 4 4 4 0 Piezo Pept_tRNA_hydro PF01195.19 EFX00688.1 - 2.9e-27 95.7 0.0 3.2e-27 95.5 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase DAO PF01266.24 EFX00689.1 - 2.4e-47 162.2 6.8 3.4e-47 161.7 6.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX00689.1 - 0.0087 16.3 0.3 0.037 14.3 0.3 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFX00689.1 - 0.024 13.9 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX00689.1 - 0.13 10.9 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 EFX00689.1 - 0.18 11.7 2.6 1.8 8.5 0.2 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Sulfotransfer_3 PF13469.6 EFX00691.1 - 1e-08 35.8 0.1 2.8e-08 34.4 0.1 1.7 1 1 0 1 1 1 1 Sulfotransferase family VirE PF05272.11 EFX00691.1 - 0.051 13.3 0.3 0.17 11.6 0.2 1.7 2 0 0 2 2 2 0 Virulence-associated protein E Phytoreo_S7 PF07236.11 EFX00691.1 - 0.13 10.6 0.1 0.18 10.1 0.1 1.1 1 0 0 1 1 1 0 Phytoreovirus S7 protein Nuc_sug_transp PF04142.15 EFX00692.1 - 5.6e-09 35.6 0.9 1e-08 34.7 0.9 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EFX00692.1 - 2e-05 24.8 25.5 0.00077 19.6 5.8 2.7 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EFX00692.1 - 0.00061 19.2 1.1 0.0018 17.7 1.1 1.7 1 0 0 1 1 1 1 Triose-phosphate Transporter family WBS28 PF15164.6 EFX00692.1 - 0.00083 18.7 2.8 0.00083 18.7 2.8 1.5 1 1 0 1 1 1 1 Williams-Beuren syndrome chromosomal region 28 protein homologue Phosphoesterase PF04185.14 EFX00693.1 - 3.8e-63 213.8 0.8 5e-63 213.4 0.8 1.2 1 0 0 1 1 1 1 Phosphoesterase family Inhibitor_I78 PF11720.8 EFX00694.1 - 1.9e-07 31.0 0.0 2.3e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family DUF1485 PF07364.12 EFX00695.1 - 4.5e-107 357.6 4.1 5.8e-107 357.3 4.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M81 MlrC_C PF07171.12 EFX00695.1 - 2e-63 213.8 0.3 3.8e-63 212.9 0.0 1.6 2 0 0 2 2 2 1 MlrC C-terminus DnaJ PF00226.31 EFX00696.1 - 2.6e-11 43.5 0.2 4.6e-11 42.7 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Nitroreductase PF00881.24 EFX00696.1 - 0.039 14.0 1.6 0.22 11.6 1.6 1.9 1 1 0 1 1 1 0 Nitroreductase family PRA1 PF03208.19 EFX00696.1 - 0.068 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 PRA1 family protein Zn_clus PF00172.18 EFX00697.1 - 2.6e-10 40.3 10.6 4.9e-10 39.4 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX00697.1 - 7e-07 28.5 1.5 2.5e-06 26.7 1.5 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain DLH PF01738.18 EFX00698.1 - 2.5e-12 46.8 0.0 3.1e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Bac_rhamnosid6H PF17389.2 EFX00699.1 - 2.3e-127 425.0 0.0 3e-127 424.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EFX00699.1 - 5.4e-56 189.1 1.5 1.1e-55 188.2 0.1 2.2 3 0 0 3 3 3 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EFX00699.1 - 1.7e-26 92.2 0.0 2.9e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 EFX00699.1 - 1.6e-24 85.5 0.0 3.6e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Stb3 PF10330.9 EFX00700.1 - 6.2e-33 112.7 0.0 1.1e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Putative Sin3 binding protein AA_kinase PF00696.28 EFX00702.1 - 1.9e-39 135.7 0.5 2.6e-39 135.3 0.5 1.1 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EFX00702.1 - 2.5e-17 62.6 0.7 1.7e-16 59.9 0.1 2.3 2 0 0 2 2 2 1 PUA domain NYD-SP28_assoc PF14775.6 EFX00702.1 - 0.081 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Sperm tail C-terminal domain Scs3p PF10261.9 EFX00703.1 - 5.8e-60 202.9 0.3 1.1e-58 198.7 0.3 2.0 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM MBOAT PF03062.19 EFX00706.1 - 4.3e-19 69.1 17.2 6.8e-19 68.4 17.2 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EFX00706.1 - 0.00016 21.9 3.2 0.00051 20.3 3.2 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family TOH_N PF12549.8 EFX00706.1 - 0.0089 15.8 0.3 0.032 14.1 0.3 2.0 1 0 0 1 1 1 1 Tyrosine hydroxylase N terminal LRR_6 PF13516.6 EFX00708.1 - 2.6e-15 55.1 20.0 0.58 10.3 0.0 11.5 12 0 0 12 12 12 5 Leucine Rich repeat F-box-like PF12937.7 EFX00708.1 - 3.1e-13 49.4 0.2 1.5e-12 47.2 0.5 2.1 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EFX00708.1 - 4.6e-08 33.2 5.3 2.8 8.5 0.1 6.9 6 1 2 8 8 8 3 Leucine Rich repeats (2 copies) F-box PF00646.33 EFX00708.1 - 0.00012 21.9 1.3 0.0002 21.1 0.1 2.1 2 0 0 2 2 2 1 F-box domain DUF1699 PF08004.11 EFX00708.1 - 0.064 12.9 0.2 3 7.5 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1699) LRR_1 PF00560.33 EFX00708.1 - 1.3 9.9 11.4 1.1e+02 4.0 0.0 7.0 7 0 0 7 7 7 0 Leucine Rich Repeat ACC_central PF08326.12 EFX00709.1 - 1.2e-270 899.9 0.0 1.4e-270 899.6 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EFX00709.1 - 7.5e-184 612.0 0.0 1e-183 611.5 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EFX00709.1 - 1.7e-52 178.0 0.0 3e-52 177.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFX00709.1 - 1.3e-27 96.5 0.1 2.8e-27 95.4 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFX00709.1 - 1e-20 73.8 0.0 4.1e-19 68.7 0.0 2.7 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFX00709.1 - 1e-17 63.7 0.1 2.4e-17 62.5 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EFX00709.1 - 0.0047 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 EFX00709.1 - 0.0064 16.3 0.0 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 EFX00709.1 - 0.0084 16.2 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain GxGYxYP_N PF16216.5 EFX00709.1 - 0.027 14.7 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal ATP-grasp PF02222.22 EFX00709.1 - 0.067 12.8 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Beta_protein PF14350.6 EFX00709.1 - 0.074 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Beta protein ATPgrasp_Ter PF15632.6 EFX00709.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Rad60-SLD PF11976.8 EFX00710.1 - 1.5e-21 76.0 0.4 2.5e-21 75.3 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFX00710.1 - 3.1e-05 23.6 0.1 5.6e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family TmoB PF06234.12 EFX00710.1 - 0.00076 19.5 0.1 0.0017 18.4 0.1 1.6 1 0 0 1 1 1 1 Toluene-4-monooxygenase system protein B (TmoB) Methyltransf_16 PF10294.9 EFX00712.1 - 2.1e-30 105.7 0.0 3.4e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFX00712.1 - 0.00022 21.1 0.0 0.00036 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain SGS PF05002.15 EFX00713.1 - 0.0065 16.5 1.1 0.023 14.8 0.3 2.3 2 0 0 2 2 2 1 SGS domain MFS_1 PF07690.16 EFX00714.1 - 6e-28 97.8 38.8 1e-27 97.0 32.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFX00714.1 - 7.5e-08 32.1 5.4 7.5e-08 32.1 5.4 2.2 1 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 EFX00714.1 - 3.2e-06 26.3 5.8 3.2e-06 26.3 5.8 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EFX00714.1 - 0.043 12.1 11.3 0.062 11.6 4.4 2.9 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family HgmA PF04209.13 EFX00715.1 - 2.2e-173 576.8 0.0 2.8e-173 576.5 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase PAPS_reduct PF01507.19 EFX00716.1 - 1e-27 97.3 0.0 2.6e-20 73.2 0.0 2.3 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family DUF3517 PF12030.8 EFX00717.1 - 2.5e-92 309.4 0.0 6e-92 308.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 EFX00717.1 - 9.6e-39 133.4 0.0 1.7e-38 132.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX00717.1 - 1.3e-13 51.3 4.4 7.6e-13 48.7 1.7 3.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase NAD_binding_2 PF03446.15 EFX00720.1 - 5.6e-28 98.1 0.1 9.7e-28 97.3 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFX00720.1 - 6.1e-25 87.8 3.3 7.6e-14 52.0 0.0 2.7 2 1 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EFX00720.1 - 4.1e-05 24.1 0.1 0.00012 22.6 0.1 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EFX00720.1 - 0.0022 17.9 1.6 0.0024 17.8 0.2 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_transf_4 PF13439.6 EFX00720.1 - 0.081 12.9 0.0 0.19 11.7 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase Family 4 ApbA PF02558.16 EFX00720.1 - 0.19 11.4 1.0 0.37 10.4 0.2 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Tmemb_170 PF10190.9 EFX00722.1 - 8.7e-21 74.3 17.1 1.2e-20 73.9 17.1 1.2 1 0 0 1 1 1 1 Putative transmembrane protein 170 bZIP_1 PF00170.21 EFX00723.1 - 2.7e-06 27.4 6.3 4.9e-06 26.5 6.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor DUF3890 PF13029.6 EFX00723.1 - 0.14 12.6 0.4 0.24 11.9 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3890) DUF5595 PF18077.1 EFX00723.1 - 0.17 12.0 0.2 0.29 11.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) bZIP_2 PF07716.15 EFX00723.1 - 0.81 9.8 8.9 0.74 9.9 7.6 1.6 1 1 0 1 1 1 0 Basic region leucine zipper Peptidase_M76 PF09768.9 EFX00724.1 - 1.5e-69 233.2 2.7 2.1e-69 232.7 2.7 1.2 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M91 PF14891.6 EFX00724.1 - 0.048 14.0 0.1 0.087 13.1 0.1 1.5 1 0 0 1 1 1 0 Effector protein SprT-like PF10263.9 EFX00724.1 - 0.058 13.3 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 SprT-like family DUF1660 PF07874.11 EFX00724.1 - 0.73 10.4 5.0 10 6.7 1.6 2.8 1 1 1 2 2 2 0 Prophage protein (DUF1660) AMP-binding PF00501.28 EFX00725.1 - 5.5e-40 137.2 0.0 7.2e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EFX00725.1 - 1.1e-08 34.8 1.4 4.1e-08 33.0 0.2 2.3 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EFX00725.1 - 0.00019 22.3 0.1 0.00048 21.1 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-C2H2 PF00096.26 EFX00727.1 - 3.1e-23 80.9 51.5 0.00033 20.9 0.4 10.4 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX00727.1 - 1.4e-17 62.9 56.8 0.01 16.6 0.5 10.8 11 0 0 11 11 11 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX00727.1 - 5.8e-11 42.3 52.1 7e-05 23.1 0.4 9.6 11 0 0 11 11 9 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EFX00727.1 - 3.3e-08 33.6 19.7 0.28 11.5 0.3 8.8 11 0 0 11 11 10 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX00727.1 - 0.00016 22.0 19.6 9.1 6.8 0.0 7.8 9 0 0 9 9 8 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EFX00727.1 - 0.0059 16.9 21.3 0.013 15.7 1.4 4.9 4 1 2 6 6 6 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 EFX00727.1 - 0.011 16.3 0.2 0.011 16.3 0.2 6.8 6 2 2 8 8 8 0 FOXP coiled-coil domain zf_Hakai PF18408.1 EFX00727.1 - 0.032 13.9 0.0 0.032 13.9 0.0 6.6 8 0 0 8 8 7 0 C2H2 Hakai zinc finger domain zf-C2H2_aberr PF17017.5 EFX00727.1 - 0.49 10.5 10.0 1.4 9.1 0.4 4.6 5 2 0 5 5 5 0 Aberrant zinc-finger zinc_ribbon_15 PF17032.5 EFX00727.1 - 0.63 10.8 9.5 0.57 11.0 0.8 2.9 3 0 0 3 3 3 0 zinc-ribbon family zf-LYAR PF08790.11 EFX00727.1 - 0.99 9.4 9.0 12 5.9 0.2 4.9 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 EFX00727.1 - 1.1 9.1 29.9 1 9.2 0.1 7.2 7 0 0 7 7 7 0 zinc-finger C2H2-type Spt46 PF17734.1 EFX00727.1 - 2.2 8.1 9.3 8.6 6.1 0.7 3.4 1 1 2 3 3 3 0 Spermatogenesis-associated protein 46 Glyco_hydro_1 PF00232.18 EFX00728.1 - 4.1e-147 490.3 0.0 5.2e-147 489.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 ABC1 PF03109.16 EFX00730.1 - 2.3e-21 76.1 0.0 3.3e-12 46.6 0.0 2.5 2 0 0 2 2 2 2 ABC1 family RIO1 PF01163.22 EFX00730.1 - 0.013 15.1 0.0 0.036 13.7 0.0 1.7 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 EFX00730.1 - 0.042 13.8 3.1 0.11 12.4 0.9 2.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family XRCC4 PF06632.12 EFX00731.1 - 7.3 5.3 6.4 0.69 8.7 2.0 1.4 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 PBP1_TM PF14812.6 EFX00731.1 - 7.9 6.9 6.8 23 5.5 0.0 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rax2 PF12768.7 EFX00732.1 - 0.064 12.7 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF533 PF04391.12 EFX00732.1 - 0.099 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) CDC37_N PF03234.14 EFX00733.1 - 1.6e-48 164.8 3.0 2.1e-48 164.5 0.2 2.6 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EFX00733.1 - 5.1e-28 97.4 0.4 1.1e-27 96.3 0.0 1.8 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EFX00733.1 - 8.3e-27 93.3 3.1 4.5e-26 90.9 0.3 2.6 2 0 0 2 2 2 1 Cdc37 C terminal domain DUF2868 PF11067.8 EFX00733.1 - 0.2 11.1 7.6 0.062 12.8 4.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2868) SNF2_N PF00176.23 EFX00734.1 - 4.8e-48 163.7 0.2 1.7e-47 161.8 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX00734.1 - 8.5e-20 71.2 0.4 3.5e-19 69.2 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX00734.1 - 1.7e-07 31.4 0.0 4.5e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EFX00734.1 - 0.00035 20.3 0.0 0.054 13.1 0.0 2.7 3 0 0 3 3 3 2 SWI2/SNF2 ATPase Acyltransferase PF01553.21 EFX00735.1 - 1.3e-27 96.0 0.0 5.2e-27 94.1 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase Acyltransf_C PF16076.5 EFX00735.1 - 0.01 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase C-terminus Creatinase_N_2 PF16189.5 EFX00736.1 - 4.7e-51 173.1 0.0 2.1e-50 171.0 0.0 2.1 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EFX00736.1 - 5.3e-44 150.4 0.0 8.1e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EFX00736.1 - 1.2e-22 79.8 0.3 3.5e-22 78.2 0.3 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EFX00736.1 - 1.1e-19 71.4 0.1 3.9e-15 56.7 0.0 3.2 4 0 0 4 4 4 2 Creatinase/Prolidase N-terminal domain Repressor_Mnt PF11423.8 EFX00736.1 - 0.1 12.4 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 Regulatory protein Mnt SET PF00856.28 EFX00738.1 - 3.7e-08 33.9 0.1 2.3e-07 31.4 0.0 2.1 2 1 0 2 2 2 1 SET domain Tmemb_55A PF09788.9 EFX00738.1 - 0.08 12.0 0.1 0.18 10.9 0.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 55A FAM76 PF16046.5 EFX00738.1 - 3.1 7.1 5.4 0.34 10.2 0.7 1.7 2 0 0 2 2 2 0 FAM76 protein Ribosomal_L24e PF01246.20 EFX00739.1 - 3.7e-32 110.3 6.4 8.6e-32 109.2 6.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e DUF3602 PF12223.8 EFX00740.1 - 5.5e-13 49.3 22.5 3.3e-07 30.8 2.2 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) HABP4_PAI-RBP1 PF04774.15 EFX00740.1 - 0.00095 20.0 2.2 0.49 11.3 0.4 2.2 2 0 0 2 2 2 2 Hyaluronan / mRNA binding family GTP1_OBG PF01018.22 EFX00740.1 - 0.45 10.1 9.6 3.7 7.1 0.4 3.1 1 1 2 3 3 3 0 GTP1/OBG TetR_C_1 PF02909.17 EFX00740.1 - 2 8.2 4.2 11 5.9 1.4 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2020 PF09449.10 EFX00740.1 - 2.2 8.1 6.8 1.2 9.0 4.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2020) Med10 PF09748.9 EFX00741.1 - 3.6e-38 130.2 0.0 5.1e-38 129.8 0.0 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Fungal_trans_2 PF11951.8 EFX00742.1 - 0.0047 15.8 1.6 0.0049 15.7 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain RCC1 PF00415.18 EFX00743.1 - 8.2e-58 192.8 11.6 4.9e-10 39.9 0.2 7.9 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFX00743.1 - 2.2e-44 148.4 22.2 5.2e-11 42.0 0.3 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.6 EFX00743.1 - 0.0047 16.7 0.1 0.049 13.4 0.1 2.6 2 0 0 2 2 2 1 PapC C-terminal domain FA_hydroxylase PF04116.13 EFX00745.1 - 1.2e-24 87.2 14.7 1.2e-24 87.2 14.7 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily PAP2_3 PF14378.6 EFX00745.1 - 0.0038 16.9 2.0 0.0038 16.9 2.0 2.0 2 0 0 2 2 2 1 PAP2 superfamily Gpr1_Fun34_YaaH PF01184.19 EFX00745.1 - 0.35 10.5 5.3 1.8 8.1 4.0 2.1 2 0 0 2 2 2 0 GPR1/FUN34/yaaH family ParA PF10609.9 EFX00746.1 - 5.8e-91 304.3 0.0 7.3e-91 304.0 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFX00746.1 - 6.1e-11 42.5 0.0 1.3e-10 41.4 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EFX00746.1 - 2.5e-06 27.0 0.0 2.9e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EFX00746.1 - 1.1e-05 25.4 0.2 7.7e-05 22.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFX00746.1 - 0.0001 21.6 0.6 0.00019 20.7 0.6 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase MeaB PF03308.16 EFX00746.1 - 0.0035 16.4 0.3 0.0054 15.7 0.3 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EFX00746.1 - 0.0071 15.9 1.4 0.0075 15.9 0.3 1.5 2 0 0 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 EFX00746.1 - 0.013 15.0 0.1 0.034 13.6 0.1 1.7 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EFX00746.1 - 0.055 13.4 0.1 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_26 PF13500.6 EFX00746.1 - 0.18 11.6 0.5 17 5.2 0.9 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFX00746.1 - 0.25 11.7 0.6 0.51 10.7 0.6 1.4 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFX00746.1 - 0.26 11.2 0.9 0.61 10.0 0.9 1.6 1 0 0 1 1 1 0 RsgA GTPase HK PF02110.15 EFX00747.1 - 1.7e-58 197.9 8.3 7.3e-58 195.8 8.3 2.2 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EFX00747.1 - 1e-41 142.3 3.7 1e-41 142.3 3.7 2.3 3 0 0 3 3 3 1 Thiamine monophosphate synthase Carb_kinase PF01256.17 EFX00747.1 - 0.0013 18.2 0.3 0.0041 16.6 0.3 1.8 1 0 0 1 1 1 1 Carbohydrate kinase Zn_clus PF00172.18 EFX00747.1 - 0.022 14.9 8.4 0.04 14.0 8.4 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX00747.1 - 0.03 13.3 0.0 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF1729 PF08354.10 EFX00747.1 - 0.047 12.6 0.2 1.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1729) TAP35_44 PF07265.11 EFX00747.1 - 0.052 13.6 0.6 0.68 10.0 0.7 2.4 2 0 0 2 2 2 0 Tapetum specific protein TAP35/TAP44 HalX PF08663.10 EFX00747.1 - 0.27 11.6 3.3 15 6.0 0.0 2.8 3 0 0 3 3 3 0 HalX domain DUF4611 PF15387.6 EFX00747.1 - 0.42 10.9 2.5 29 5.0 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) DUF2802 PF10975.8 EFX00747.1 - 0.66 10.1 4.1 11 6.3 0.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) Ribonuc_L-PSP PF01042.21 EFX00749.1 - 1.8e-35 121.6 0.0 2e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF3182 PF11379.8 EFX00749.1 - 0.034 13.1 0.0 0.042 12.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) NCD1 PF04904.13 EFX00750.1 - 0.17 11.9 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) RabGAP-TBC PF00566.18 EFX00751.1 - 1.2e-20 74.1 0.1 7.6e-12 45.3 0.3 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Macoilin PF09726.9 EFX00751.1 - 0.17 10.4 1.1 0.26 9.8 1.1 1.2 1 0 0 1 1 1 0 Macoilin family Corona_nucleoca PF00937.18 EFX00751.1 - 0.97 8.4 9.5 2.8 6.9 9.5 1.7 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein ODV-E18 PF10717.9 EFX00751.1 - 1.8 8.5 5.9 8.6 6.3 5.9 2.3 1 1 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 PEP-utilizers PF00391.23 EFX00752.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain UDG PF03167.19 EFX00753.1 - 2.3e-23 82.9 0.1 4.2e-23 82.0 0.1 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily PT PF04886.12 EFX00753.1 - 1.2 8.7 14.3 1.1 8.9 9.8 2.9 2 0 0 2 2 2 0 PT repeat CDC27 PF09507.10 EFX00753.1 - 3.5 6.9 60.6 0.51 9.7 1.3 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 DUF3835 PF12927.7 EFX00754.1 - 2e-25 89.4 0.1 2e-25 89.4 0.1 4.9 5 1 0 5 5 5 1 Domain of unknown function (DUF3835) Prefoldin_3 PF13758.6 EFX00754.1 - 9.4e-20 70.5 0.1 3.1e-19 68.9 0.1 1.9 1 0 0 1 1 1 1 Prefoldin subunit Pox_A_type_inc PF04508.12 EFX00754.1 - 0.11 12.4 1.1 1.6 8.7 0.2 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat CENP-B_dimeris PF09026.10 EFX00754.1 - 4.6 7.7 20.7 5.8 7.4 10.6 3.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RhoGAP PF00620.27 EFX00755.1 - 2.2e-44 150.9 0.1 4.3e-44 150.0 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EFX00755.1 - 2.3e-12 47.3 0.0 4.3e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFX00755.1 - 0.031 14.5 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain RskA PF10099.9 EFX00756.1 - 0.0077 16.5 9.0 0.0077 16.5 9.0 2.0 2 0 0 2 2 2 1 Anti-sigma-K factor rskA LCAT PF02450.15 EFX00757.1 - 4.8e-102 342.1 0.0 5.7e-102 341.8 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EFX00757.1 - 0.001 19.7 0.3 0.0022 18.6 0.3 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.10 EFX00757.1 - 0.047 12.8 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Sec23_trunk PF04811.15 EFX00758.1 - 4.8e-67 226.1 0.0 7.2e-67 225.5 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EFX00758.1 - 2.2e-22 78.8 0.0 9.9e-22 76.7 0.0 2.2 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EFX00758.1 - 5.8e-18 65.4 0.1 1.3e-17 64.3 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFX00758.1 - 1.5e-16 60.1 5.1 2.7e-16 59.3 5.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFX00758.1 - 2.7e-10 40.0 0.0 6.1e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EFX00758.1 - 0.035 13.5 0.1 0.079 12.4 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain VWA_2 PF13519.6 EFX00758.1 - 0.18 12.5 0.0 7.7 7.2 0.0 3.1 3 0 0 3 3 3 0 von Willebrand factor type A domain Raffinose_syn PF05691.12 EFX00759.1 - 1.3e-44 152.2 0.0 1.4e-36 125.6 0.0 2.3 1 1 1 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Sel1 PF08238.12 EFX00760.1 - 1.8e-16 60.2 32.1 4.4e-07 30.4 0.6 7.8 7 0 0 7 7 7 6 Sel1 repeat TPR_1 PF00515.28 EFX00760.1 - 0.02 14.7 5.9 0.033 14.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt20 PF12090.8 EFX00760.1 - 0.093 12.3 25.1 0.2 11.3 25.1 1.5 1 0 0 1 1 1 0 Spt20 family TPR_12 PF13424.6 EFX00760.1 - 0.38 11.1 3.9 7.8 6.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4834 PF16118.5 EFX00760.1 - 6.2 7.9 7.2 20 6.3 7.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DNA_primase_S PF01896.19 EFX00761.1 - 2e-61 207.1 0.1 4.2e-61 206.1 0.1 1.5 2 0 0 2 2 2 1 DNA primase small subunit Mito_carr PF00153.27 EFX00762.1 - 1.4e-58 194.8 1.0 2.5e-19 69.0 0.0 4.3 4 0 0 4 4 4 4 Mitochondrial carrier protein DUF4148 PF13663.6 EFX00762.1 - 0.015 15.5 7.0 2.9 8.1 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) WD40 PF00400.32 EFX00763.1 - 0.00074 20.3 4.5 0.017 16.0 0.1 4.3 3 1 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX00763.1 - 0.05 13.9 0.0 0.93 9.8 0.0 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SPX PF03105.19 EFX00764.1 - 5.4e-47 161.5 0.0 8.7e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.6 EFX00764.1 - 2.6e-07 30.7 8.8 5.9e-07 29.5 8.8 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EFX00764.1 - 3e-07 30.2 8.3 5.6e-07 29.3 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX00764.1 - 1e-06 28.5 8.9 2.1e-06 27.5 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX00764.1 - 2.9e-05 24.0 7.4 6.4e-05 22.9 7.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFX00764.1 - 3.9e-05 23.9 11.4 7.8e-05 22.9 11.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFX00764.1 - 7e-05 22.6 10.7 0.00015 21.6 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX00764.1 - 0.0014 18.6 11.9 0.014 15.3 12.5 2.1 1 1 1 2 2 2 1 zinc-RING finger domain NOB1_Zn_bind PF08772.11 EFX00764.1 - 0.0037 17.4 0.7 2.6 8.3 0.8 2.6 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like DHQ_synthase PF01761.20 EFX00764.1 - 0.013 14.6 0.1 0.024 13.8 0.1 1.3 1 0 0 1 1 1 0 3-dehydroquinate synthase Prok-RING_4 PF14447.6 EFX00764.1 - 0.074 12.9 9.7 0.79 9.6 10.3 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFX00764.1 - 0.079 13.0 3.1 0.15 12.1 3.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFX00764.1 - 0.26 11.1 11.1 0.053 13.3 5.5 2.6 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EFX00764.1 - 0.47 10.5 3.5 1.4 9.0 3.5 1.8 1 0 0 1 1 1 0 Double zinc ribbon zf-rbx1 PF12678.7 EFX00764.1 - 1.7 9.0 10.8 5.9 7.3 10.8 1.8 1 1 1 2 2 2 0 RING-H2 zinc finger domain UCH PF00443.29 EFX00765.1 - 3.5e-35 121.8 0.0 6.6e-35 120.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EFX00765.1 - 8e-13 48.1 0.1 7e-06 25.9 0.0 3.4 3 0 0 3 3 3 2 A repeated domain in UCH-protein UCH_1 PF13423.6 EFX00765.1 - 7.5e-06 25.8 1.6 0.0059 16.2 0.0 2.9 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Kelch_4 PF13418.6 EFX00765.1 - 0.12 12.4 0.1 0.35 10.9 0.1 1.8 1 0 0 1 1 1 0 Galactose oxidase, central domain UIM PF02809.20 EFX00765.1 - 8.8 6.5 9.5 0.53 10.3 2.1 3.0 2 0 0 2 2 2 0 Ubiquitin interaction motif RRM_1 PF00076.22 EFX00766.1 - 1.4e-10 40.8 0.1 2.8e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFX00766.1 - 7e-06 25.6 0.0 1.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 EFX00766.1 - 0.017 15.1 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain WD40 PF00400.32 EFX00767.1 - 1.5e-06 28.9 0.1 0.047 14.6 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Mito_carr PF00153.27 EFX00768.1 - 2.4e-66 219.7 5.5 7.6e-23 80.3 0.2 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFX00768.1 - 0.042 13.0 3.1 0.65 9.1 0.1 3.2 1 1 2 3 3 3 0 Gammaproteobacterial serine protease PPR_2 PF13041.6 EFX00769.1 - 2.9e-11 43.4 0.1 2.3e-06 27.7 0.0 4.2 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 EFX00769.1 - 1.1e-06 28.4 5.0 0.002 18.3 0.0 4.9 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.6 EFX00769.1 - 0.0071 16.4 0.0 3.8 7.7 0.0 3.1 3 0 0 3 3 3 2 Pentatricopeptide repeat domain TPR_14 PF13428.6 EFX00769.1 - 3.8 8.6 0.0 3.8 8.6 0.0 6.8 7 1 0 7 7 7 0 Tetratricopeptide repeat Lgl_C PF08596.10 EFX00770.1 - 7.7e-109 364.0 0.0 1.1e-108 363.5 0.0 1.2 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 EFX00770.1 - 1.1e-06 29.3 1.9 0.027 15.3 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX00770.1 - 0.00012 22.2 0.0 9.2 6.7 0.0 4.8 3 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFX00770.1 - 0.17 11.5 6.3 3.9 7.0 0.1 3.6 3 1 0 4 4 4 0 PQQ-like domain Cyclin_N PF00134.23 EFX00771.1 - 3e-38 130.4 0.1 4.9e-38 129.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFX00771.1 - 1.2e-10 41.5 0.1 7.9e-10 38.9 0.1 2.2 1 1 0 1 1 1 1 Cyclin, C-terminal domain Prefoldin PF02996.17 EFX00772.1 - 5.9e-30 103.6 0.2 1.8e-29 102.1 0.2 1.7 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EFX00772.1 - 0.0028 17.6 0.3 0.093 12.7 0.1 2.4 2 1 0 2 2 2 1 Prefoldin subunit Filament PF00038.21 EFX00772.1 - 0.0044 16.7 1.2 1.7 8.2 0.2 2.1 2 0 0 2 2 2 2 Intermediate filament protein APG17 PF04108.12 EFX00772.1 - 0.046 12.8 0.8 0.082 12.0 0.0 1.7 2 0 0 2 2 2 0 Autophagy protein Apg17 SlyX PF04102.12 EFX00772.1 - 3.8 8.2 5.3 13 6.5 0.1 2.9 3 0 0 3 3 3 0 SlyX COG6 PF06419.11 EFX00773.1 - 2.7e-163 544.5 1.3 6.7e-137 457.3 0.0 2.0 1 1 1 2 2 2 2 Conserved oligomeric complex COG6 BET PF17035.5 EFX00773.1 - 0.00059 20.0 0.7 1.9 8.7 0.1 3.2 3 0 0 3 3 3 2 Bromodomain extra-terminal - transcription regulation Spc7 PF08317.11 EFX00773.1 - 0.0033 16.4 3.7 1.2 8.0 0.1 3.2 3 0 0 3 3 3 3 Spc7 kinetochore protein RmuC PF02646.16 EFX00773.1 - 0.081 12.0 0.2 0.98 8.5 0.1 2.3 2 0 0 2 2 2 0 RmuC family Zn_clus PF00172.18 EFX00774.1 - 4.3e-05 23.5 9.5 4.3e-05 23.5 9.5 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX00774.1 - 6.4e-05 22.1 0.1 0.00014 21.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1289 PF06945.13 EFX00774.1 - 0.34 10.7 6.3 0.06 13.2 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1289) zf-TRAF PF02176.18 EFX00774.1 - 4.3 8.1 6.8 9.9 6.9 0.1 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger DUF1771 PF08590.10 EFX00775.1 - 4.7e-15 55.7 11.6 9.6e-15 54.7 11.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EFX00775.1 - 1.6e-07 31.5 0.0 4.3e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Smr domain zf-CCCH PF00642.24 EFX00775.1 - 0.0012 18.7 0.3 0.0022 17.8 0.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFX00775.1 - 0.088 13.3 0.7 0.14 12.7 0.7 1.3 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger CDV3 PF15359.6 EFX00775.1 - 0.094 13.2 0.2 0.4 11.2 0.2 2.1 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 zf_CCCH_4 PF18345.1 EFX00775.1 - 0.21 11.7 1.3 0.67 10.1 1.3 1.8 1 1 0 1 1 1 0 Zinc finger domain DUF99 PF01949.16 EFX00775.1 - 0.22 10.9 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF99 zf-CCCH_4 PF18044.1 EFX00775.1 - 1.7 8.6 3.9 11 5.9 3.9 2.1 1 1 0 1 1 1 0 CCCH-type zinc finger HEM4 PF02602.15 EFX00776.1 - 1.5e-37 129.2 0.0 1.9e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Vac14_Fig4_bd PF11916.8 EFX00777.1 - 4.5e-60 202.4 11.0 3.1e-33 114.9 3.6 2.5 1 1 1 2 2 2 2 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EFX00777.1 - 1.3e-43 147.6 0.1 1e-40 138.2 0.0 4.2 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFX00777.1 - 9.2e-07 29.2 3.8 0.00048 20.6 0.1 4.4 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 EFX00777.1 - 2e-06 27.6 1.5 0.0048 17.0 0.1 5.0 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 EFX00777.1 - 5.5e-06 26.5 2.4 0.0085 16.1 0.3 3.7 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EFX00777.1 - 0.026 14.6 0.1 11 6.3 0.0 4.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat MFS_1 PF07690.16 EFX00778.1 - 3.6e-39 134.7 45.6 4.8e-39 134.3 43.2 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX00778.1 - 1.7e-10 40.0 12.8 2.4e-10 39.5 12.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TFIIS_M PF07500.14 EFX00779.1 - 2.4e-26 92.4 1.4 3.6e-26 91.8 0.3 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EFX00779.1 - 2.5e-18 65.6 8.0 4e-18 65.0 8.0 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EFX00779.1 - 7.9e-12 45.0 0.4 2.3e-11 43.5 0.4 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain AflR PF08493.10 EFX00780.1 - 2.6e-12 46.8 0.8 2.6e-12 46.8 0.8 1.9 2 1 0 2 2 2 1 Aflatoxin regulatory protein NPL4 PF05021.15 EFX00781.1 - 3.7e-136 453.5 0.0 5e-136 453.0 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EFX00781.1 - 9.1e-68 227.0 0.1 1.3e-67 226.4 0.1 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EFX00781.1 - 0.0016 18.9 0.0 0.0079 16.7 0.0 2.1 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 RCC1 PF00415.18 EFX00782.1 - 3.7e-25 88.3 2.5 2e-06 28.3 0.0 7.4 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFX00782.1 - 2.4e-10 40.0 22.3 5.6e-09 35.6 0.1 7.0 7 0 0 7 7 7 2 Regulator of chromosome condensation (RCC1) repeat Methyltransf_28 PF02636.17 EFX00783.1 - 2.7e-38 132.1 0.0 5.1e-38 131.2 0.0 1.5 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MCPVI PF02993.14 EFX00785.1 - 0.0062 16.4 9.7 0.067 13.0 3.4 2.4 2 1 0 2 2 2 2 Minor capsid protein VI WD40 PF00400.32 EFX00786.1 - 3.3e-14 53.0 11.2 0.085 13.8 0.0 8.3 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX00786.1 - 5.1e-09 36.3 0.0 0.00054 20.2 0.0 5.0 5 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFX00786.1 - 0.0003 20.6 0.1 10 6.2 0.0 3.9 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 EFX00786.1 - 0.0026 17.2 0.0 0.043 13.3 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5046) Ge1_WD40 PF16529.5 EFX00786.1 - 0.019 13.9 0.1 3 6.7 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SDA1 PF05285.12 EFX00786.1 - 0.53 9.7 16.3 0.14 11.6 3.3 2.2 2 0 0 2 2 2 0 SDA1 TRAP_alpha PF03896.16 EFX00786.1 - 7.6 5.6 9.1 2.6 7.2 4.2 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit YL1 PF05764.13 EFX00786.1 - 7.8 6.5 13.8 1.3 9.1 4.7 2.3 2 0 0 2 2 2 0 YL1 nuclear protein zf-C2H2_2 PF12756.7 EFX00787.1 - 4.9e-27 94.2 1.0 8.1e-27 93.5 1.0 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) SlyX PF04102.12 EFX00787.1 - 0.078 13.6 1.9 0.28 11.8 1.0 2.3 2 0 0 2 2 2 0 SlyX zf-C2H2_4 PF13894.6 EFX00787.1 - 2 9.4 4.5 27 6.0 0.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Cation_efflux PF01545.21 EFX00789.1 - 4.9e-52 176.6 0.0 3e-35 121.7 0.0 2.1 2 0 0 2 2 2 2 Cation efflux family Ank_2 PF12796.7 EFX00789.1 - 0.00015 22.3 0.0 0.00033 21.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX00789.1 - 0.00032 21.2 0.1 0.002 18.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFX00789.1 - 0.0007 19.9 0.1 11 6.7 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat DNA_methylase PF00145.17 EFX00790.1 - 2.9e-36 125.5 0.0 1.7e-27 96.6 0.0 2.1 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase BAH PF01426.18 EFX00790.1 - 5.7e-06 26.2 0.0 0.069 13.0 0.0 2.7 2 1 0 2 2 2 2 BAH domain CSN8_PSD8_EIF3K PF10075.9 EFX00791.1 - 2.1e-17 63.4 0.0 3.4e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EFX00791.1 - 0.058 12.8 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 SAC3/GANP family Abhydrolase_1 PF00561.20 EFX00792.1 - 4.1e-15 56.1 0.1 6.4e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX00792.1 - 9.1e-06 25.1 0.0 0.00012 21.5 0.0 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Rad4 PF03835.15 EFX00793.1 - 1.3e-14 54.1 1.8 2.7e-14 53.1 1.8 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EFX00793.1 - 4.2e-14 53.0 2.8 1.1e-13 51.5 2.8 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SAP130_C PF16014.5 EFX00793.1 - 2.6 7.1 5.9 0.17 11.0 0.1 1.8 2 0 0 2 2 2 0 Histone deacetylase complex subunit SAP130 C-terminus iPGM_N PF06415.13 EFX00794.1 - 1.8e-76 256.4 0.0 2.5e-76 255.9 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EFX00794.1 - 1.4e-64 217.9 0.0 1.6e-64 217.7 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EFX00794.1 - 3.4e-06 26.7 0.0 2.1e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFX00794.1 - 5.5e-05 22.9 0.0 0.00014 21.6 0.0 1.6 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase AAA PF00004.29 EFX00795.1 - 7.5e-38 130.0 0.0 1.8e-37 128.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX00795.1 - 5.7e-08 32.4 0.0 2e-07 30.7 0.0 1.9 2 0 0 2 2 1 1 AAA+ lid domain Vps4_C PF09336.10 EFX00795.1 - 3.3e-07 30.2 0.1 2.6e-06 27.3 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 EFX00795.1 - 3.9e-05 23.9 0.7 0.0012 19.1 0.1 2.8 2 1 1 3 3 2 1 AAA domain RuvB_N PF05496.12 EFX00795.1 - 9.1e-05 22.3 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFX00795.1 - 0.00069 19.8 0.0 0.0013 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFX00795.1 - 0.0015 18.5 0.1 0.0065 16.5 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFX00795.1 - 0.0038 16.5 0.0 0.0069 15.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EFX00795.1 - 0.0044 16.8 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFX00795.1 - 0.0049 16.3 0.1 0.012 15.1 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EFX00795.1 - 0.0052 17.2 0.5 0.0052 17.2 0.5 3.2 4 1 0 4 4 2 1 AAA ATPase domain DUF815 PF05673.13 EFX00795.1 - 0.014 14.6 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 EFX00795.1 - 0.031 13.8 0.1 0.12 12.0 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 EFX00795.1 - 0.033 14.3 0.0 0.078 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFX00795.1 - 0.048 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFX00795.1 - 0.058 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFX00795.1 - 0.092 13.3 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFX00795.1 - 0.13 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MIT PF04212.18 EFX00795.1 - 0.13 12.3 0.2 0.33 11.1 0.2 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain AAA_28 PF13521.6 EFX00795.1 - 0.18 12.0 0.5 0.83 9.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EFX00795.1 - 0.2 11.1 0.2 0.51 9.8 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EFX00795.1 - 0.23 10.9 0.0 0.53 9.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ASF1_hist_chap PF04729.13 EFX00796.1 - 4.7e-73 244.2 0.0 6.1e-73 243.9 0.0 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone Na_trans_assoc PF06512.13 EFX00796.1 - 1 9.6 7.2 1.2 9.4 7.2 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated Suf PF05843.14 EFX00797.1 - 1.2e-76 258.6 0.0 1.2e-73 248.8 0.0 2.8 2 1 0 2 2 2 2 Suppressor of forked protein (Suf) TPR_16 PF13432.6 EFX00797.1 - 2.6e-07 31.2 0.4 1.3e-06 29.0 0.4 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFX00797.1 - 9.3e-05 22.9 10.2 0.0016 19.1 0.1 6.5 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFX00797.1 - 0.0011 19.5 0.1 0.047 14.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00797.1 - 0.48 10.7 2.0 2.4 8.5 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ATP-synt_C PF00137.21 EFX00799.1 - 1.8e-10 41.0 13.1 1.8e-10 41.0 13.1 1.7 2 0 0 2 2 2 1 ATP synthase subunit C RasGAP PF00616.19 EFX00800.1 - 6.3e-59 199.2 0.0 1.9e-58 197.6 0.0 1.9 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFX00800.1 - 1.4e-28 99.8 2.7 1.4e-28 99.8 2.7 2.2 2 0 0 2 2 2 1 RasGAP C-terminus Spc7 PF08317.11 EFX00800.1 - 0.9 8.4 9.1 1.3 7.8 2.8 2.6 2 0 0 2 2 2 0 Spc7 kinetochore protein YabA PF06156.13 EFX00800.1 - 1 10.0 5.9 14 6.4 1.0 2.8 2 0 0 2 2 2 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 EFX00800.1 - 7.4 6.6 10.7 1 9.4 1.6 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PAP2_3 PF14378.6 EFX00801.1 - 8e-22 77.8 15.0 8e-22 77.8 15.0 1.9 2 1 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EFX00801.1 - 1.3e-09 37.9 8.1 1.3e-09 37.9 8.1 2.7 1 1 2 3 3 3 1 PAP2 superfamily Period_C PF12114.8 EFX00801.1 - 1.3 8.6 2.5 2.2 7.8 2.5 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF155 PF02582.14 EFX00802.1 - 8.5e-46 156.2 0.0 1.2e-45 155.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Rhomboid_SP PF12595.8 EFX00802.1 - 4.8 6.5 7.6 4.1 6.7 0.4 2.3 1 1 1 2 2 2 0 Rhomboid serine protease CS PF04969.16 EFX00803.1 - 7.8e-13 49.3 0.0 1.5e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 CS domain SRP14 PF02290.15 EFX00804.1 - 3.6e-25 88.2 0.1 1e-24 86.7 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle 14kD protein SF3a60_bindingd PF12108.8 EFX00804.1 - 0.051 13.5 0.5 1.9 8.4 0.0 2.3 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain DUF4449 PF14613.6 EFX00804.1 - 0.054 13.6 2.4 0.07 13.2 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) EMG1 PF03587.14 EFX00806.1 - 1.7e-78 262.8 0.1 2e-78 262.5 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Vps51 PF08700.11 EFX00807.1 - 1.9e-26 92.0 0.0 3.6e-26 91.1 0.0 1.5 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 EFX00807.1 - 0.00013 20.8 0.1 0.00018 20.3 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 EFX00807.1 - 0.003 17.7 0.0 0.0065 16.7 0.0 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Xpo1 PF08389.12 EFX00808.1 - 1.9e-09 37.7 3.0 0.00023 21.2 0.1 3.7 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.19 EFX00808.1 - 5.5e-06 26.2 0.0 4.3e-05 23.4 0.0 2.6 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EFX00808.1 - 0.015 15.7 0.2 0.098 13.1 0.1 2.5 2 0 0 2 2 2 0 HEAT repeats IFRD PF05004.13 EFX00808.1 - 0.045 12.9 0.0 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 EFX00808.1 - 0.086 13.1 7.9 0.086 13.1 0.5 3.9 4 0 0 4 4 4 0 HEAT repeat MMS19_N PF14500.6 EFX00808.1 - 0.14 11.7 1.9 2.4 7.7 0.1 2.8 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 EFX00808.1 - 0.37 10.9 8.5 0.091 12.8 0.8 3.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat tRNA-synt_2 PF00152.20 EFX00810.1 - 1.2e-82 277.6 0.0 1.5e-82 277.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EFX00810.1 - 0.004 16.7 0.1 0.028 13.9 0.2 2.2 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) zf-ISL3 PF14690.6 EFX00810.1 - 0.14 12.9 0.0 0.3 11.8 0.0 1.5 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Fungal_trans_2 PF11951.8 EFX00811.1 - 8.8e-10 37.9 0.3 1.4e-09 37.3 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_11 PF08241.12 EFX00812.1 - 1.5e-10 41.5 0.0 3e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX00812.1 - 1e-08 35.2 0.0 1.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX00812.1 - 1.9e-07 31.7 0.0 5.4e-07 30.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX00812.1 - 5.9e-05 23.7 0.0 0.00017 22.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX00812.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFX00812.1 - 0.017 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EFX00812.1 - 0.026 14.4 0.0 0.16 11.8 0.0 2.0 1 1 1 2 2 2 0 Hypothetical methyltransferase Methyltransf_PK PF05891.12 EFX00812.1 - 0.087 12.3 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase RF-1 PF00472.20 EFX00813.1 - 0.011 15.7 0.2 0.013 15.4 0.2 1.1 1 0 0 1 1 1 0 RF-1 domain IMS_C PF11799.8 EFX00813.1 - 0.011 16.4 0.0 0.012 16.3 0.0 1.1 1 0 0 1 1 1 0 impB/mucB/samB family C-terminal domain DUF629 PF04780.12 EFX00813.1 - 0.08 11.5 0.1 0.083 11.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) AFP_2 PF18815.1 EFX00813.1 - 0.18 12.1 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial antifreeze protein repeat VanZ PF04892.12 EFX00814.1 - 3.1e-08 34.3 2.8 4.2e-08 33.9 2.8 1.2 1 0 0 1 1 1 1 VanZ like family DASH_Spc34 PF08657.10 EFX00815.1 - 2.6e-51 174.9 0.0 2.8e-27 96.1 0.0 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 UPF0242 PF06785.11 EFX00815.1 - 0.0063 16.6 1.4 0.0097 16.0 1.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus TMF_DNA_bd PF12329.8 EFX00815.1 - 0.034 14.1 8.4 0.17 11.9 0.4 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DASH_Spc19 PF08287.11 EFX00815.1 - 0.19 11.6 7.2 0.34 10.8 7.2 1.4 1 0 0 1 1 1 0 Spc19 DUF4407 PF14362.6 EFX00815.1 - 0.38 10.1 2.8 0.51 9.6 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EFX00815.1 - 0.5 11.0 7.3 6.2 7.5 0.4 2.4 2 0 0 2 2 2 0 SlyX OmpH PF03938.14 EFX00815.1 - 0.66 10.3 8.4 1 9.7 8.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BBS2_C PF14782.6 EFX00815.1 - 1.1 7.9 4.0 0.62 8.8 1.9 1.5 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal DivIC PF04977.15 EFX00815.1 - 1.6 8.6 7.4 11 5.9 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator FOXP-CC PF16159.5 EFX00815.1 - 1.7 9.4 6.1 3.2 8.5 1.3 2.2 2 0 0 2 2 2 0 FOXP coiled-coil domain ATG16 PF08614.11 EFX00815.1 - 5.7 7.1 17.6 2.1 8.6 13.3 2.0 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Uds1 PF15456.6 EFX00815.1 - 6 7.0 9.6 21 5.3 9.7 1.8 1 1 1 2 2 2 0 Up-regulated During Septation MOZ_SAS PF01853.18 EFX00816.1 - 4.4e-53 179.6 0.0 8e-53 178.7 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFX00816.1 - 2e-08 33.7 0.2 0.0051 16.4 0.1 2.5 2 0 0 2 2 2 2 MYST family zinc finger domain Acetyltransf_7 PF13508.7 EFX00816.1 - 0.12 12.8 0.0 0.38 11.2 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Nop14 PF04147.12 EFX00816.1 - 0.95 7.6 11.3 1.3 7.2 11.3 1.1 1 0 0 1 1 1 0 Nop14-like family FAD_binding_2 PF00890.24 EFX00817.1 - 3e-83 280.2 1.3 3.9e-83 279.9 1.3 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EFX00817.1 - 2.4e-21 75.7 0.0 8.6e-20 70.7 0.0 2.8 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EFX00817.1 - 6.5e-15 55.6 0.4 1.1e-14 54.9 0.4 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFX00817.1 - 5.1e-09 36.0 1.0 2e-08 34.1 1.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX00817.1 - 3.5e-07 29.7 0.4 4.8e-06 26.0 0.3 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX00817.1 - 1.3e-06 28.6 0.2 1.3e-06 28.6 0.2 2.9 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFX00817.1 - 2e-06 27.3 0.1 0.052 12.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX00817.1 - 5.2e-06 25.4 2.9 0.0085 14.8 0.1 3.3 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_3 PF01494.19 EFX00817.1 - 0.00017 21.0 3.2 0.00095 18.5 3.2 1.9 1 1 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EFX00817.1 - 0.00084 18.5 1.2 0.07 12.2 0.3 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EFX00817.1 - 0.0011 18.3 1.0 0.069 12.4 0.4 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EFX00817.1 - 0.0018 18.8 0.8 0.24 12.0 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EFX00817.1 - 0.028 13.7 0.6 0.05 12.9 0.6 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EFX00817.1 - 0.05 12.9 0.5 2.7 7.2 0.1 3.0 2 1 0 3 3 3 0 Flavin containing amine oxidoreductase SR-25 PF10500.9 EFX00817.1 - 4.7 6.8 10.2 7.5 6.1 10.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Period_C PF12114.8 EFX00817.1 - 5.5 6.5 7.8 9.3 5.8 7.8 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF1708 PF08101.11 EFX00818.1 - 3.3e-172 573.5 0.0 4.5e-172 573.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) GNAT_acetyltr_2 PF13718.6 EFX00819.1 - 5.8e-93 310.5 0.0 1.1e-92 309.5 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EFX00819.1 - 1.1e-75 254.4 0.0 1.6e-75 253.8 0.0 1.2 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EFX00819.1 - 5.4e-63 212.0 0.0 1.8e-62 210.4 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EFX00819.1 - 1e-32 111.9 0.0 2.5e-32 110.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EFX00819.1 - 5.5e-05 23.0 0.1 0.044 13.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFX00819.1 - 0.0036 17.6 0.0 0.22 11.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Pkinase PF00069.25 EFX00820.1 - 8.6e-64 215.4 0.1 2.6e-63 213.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00820.1 - 7.2e-47 159.8 0.4 1.3e-46 159.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00820.1 - 3.2e-06 26.7 0.0 3.2e-06 26.7 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Activator_LAG-3 PF11498.8 EFX00820.1 - 0.0078 15.2 27.3 0.02 13.9 27.3 1.6 1 0 0 1 1 1 1 Transcriptional activator LAG-3 APH PF01636.23 EFX00820.1 - 0.077 12.9 6.8 0.094 12.6 0.0 2.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFX00820.1 - 0.12 11.1 12.4 7.6 5.2 12.0 3.1 2 1 0 2 2 2 0 Fungal protein kinase PAT1 PF09770.9 EFX00820.1 - 0.5 8.6 19.2 1.1 7.5 19.2 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FTA2 PF13095.6 EFX00820.1 - 0.86 9.2 4.8 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 eIF-3_zeta PF05091.12 EFX00820.1 - 1.3 7.9 13.1 2.2 7.1 13.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 EFX00820.1 - 6.7 5.4 11.9 17 4.0 11.9 1.6 1 0 0 1 1 1 0 Presenilin 4HBT PF03061.22 EFX00821.1 - 1.6e-06 28.4 0.2 0.00044 20.5 0.2 2.3 2 0 0 2 2 2 2 Thioesterase superfamily EF-hand_like PF09279.11 EFX00821.1 - 0.13 12.7 0.1 0.23 12.0 0.1 1.3 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like THUMP PF02926.17 EFX00822.1 - 7.3e-13 48.8 0.1 1.1e-09 38.5 0.0 2.2 2 0 0 2 2 2 2 THUMP domain ORC3_N PF07034.11 EFX00823.1 - 2.3e-32 112.4 1.1 4.8e-25 88.4 0.0 3.0 2 1 1 3 3 3 2 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EFX00823.1 - 3.9e-28 98.3 2.2 3e-27 95.4 0.0 3.1 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal DUF4253 PF14062.6 EFX00823.1 - 0.051 13.8 0.0 0.26 11.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4253) DUF2263 PF10021.9 EFX00824.1 - 2.7e-18 66.7 0.0 6e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 EFX00824.1 - 0.029 14.4 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 Macro domain Thioredoxin_4 PF13462.6 EFX00825.1 - 3.8e-05 23.9 0.0 0.0001 22.5 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EFX00825.1 - 0.031 14.0 1.0 0.17 11.6 0.1 2.4 2 1 1 3 3 3 0 DSBA-like thioredoxin domain DUF2013 PF09431.10 EFX00826.1 - 2e-50 170.5 3.2 2e-50 170.5 3.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) ketoacyl-synt PF00109.26 EFX00827.1 - 8.6e-84 281.1 0.0 1.5e-83 280.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFX00827.1 - 4.8e-42 144.6 0.0 9.8e-42 143.6 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 EFX00827.1 - 7e-34 117.6 4.2 1.2e-33 116.8 0.3 2.6 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 EFX00827.1 - 2.3e-33 114.7 0.2 4.9e-33 113.6 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFX00827.1 - 4.1e-24 84.7 11.0 1.2e-11 44.8 0.5 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.20 EFX00827.1 - 6e-23 82.2 0.1 9e-22 78.3 0.0 2.4 2 0 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 EFX00827.1 - 7.1e-12 45.2 0.0 1.3e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EFX00827.1 - 8.6e-07 28.6 0.2 9.6e-06 25.1 0.0 2.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EFX00827.1 - 0.00014 22.3 0.0 0.00066 20.1 0.0 2.1 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension LPD11 PF18824.1 EFX00827.1 - 0.048 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 11 HTH_Mga PF08280.11 EFX00827.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain RRM_1 PF00076.22 EFX00829.1 - 2.3e-41 139.5 0.0 4.7e-18 64.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFX00829.1 - 0.0015 18.5 0.0 4.4 7.5 0.0 3.2 2 2 0 2 2 2 2 Limkain b1 RRM_3 PF08777.11 EFX00829.1 - 0.0024 17.9 0.0 3.4 7.8 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif RRM_Rrp7 PF17799.1 EFX00829.1 - 0.0032 17.3 0.0 0.99 9.2 0.0 2.7 3 0 0 3 3 3 1 Rrp7 RRM-like N-terminal domain ATP-grasp_2 PF08442.10 EFX00829.1 - 0.084 12.4 0.0 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain RRM_7 PF16367.5 EFX00829.1 - 0.11 12.7 0.0 37 4.5 0.0 3.1 3 0 0 3 3 3 0 RNA recognition motif BRAP2 PF07576.12 EFX00829.1 - 0.12 12.7 0.0 1.6 9.0 0.0 2.2 2 0 0 2 2 2 0 BRCA1-associated protein 2 RRM_occluded PF16842.5 EFX00829.1 - 0.15 11.9 0.0 5.2 7.0 0.0 2.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif TBCC PF07986.12 EFX00830.1 - 1.3e-29 102.4 0.0 2e-29 101.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EFX00830.1 - 4.1e-07 30.4 0.0 7.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain Fungal_trans PF04082.18 EFX00831.1 - 3e-05 23.2 0.1 0.014 14.5 0.0 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain MFS_1 PF07690.16 EFX00832.1 - 2.5e-36 125.4 58.8 2.5e-36 125.4 58.8 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX00832.1 - 8.7e-12 44.2 33.6 1.7e-11 43.3 33.2 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFX00832.1 - 2e-09 36.8 17.4 2e-09 36.8 17.4 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter RTC PF01137.21 EFX00833.1 - 1.4e-25 89.8 0.6 2.1e-25 89.2 0.6 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EFX00833.1 - 2.4e-25 89.1 0.3 5.5e-25 87.9 0.3 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Histone_H2A_C PF16211.5 EFX00834.1 - 1.2e-20 72.9 2.7 2.2e-20 72.1 2.7 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EFX00834.1 - 6.6e-17 62.1 0.0 8.6e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFX00834.1 - 1.1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Cupin_8 PF13621.6 EFX00835.1 - 4.3e-14 52.8 0.0 1.7e-12 47.7 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EFX00835.1 - 3.4e-10 40.4 0.0 7.1e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase F-box PF00646.33 EFX00835.1 - 7.9e-08 32.0 0.0 1.7e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFX00835.1 - 3.3e-07 30.1 0.0 8e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFX00835.1 - 0.069 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 F-box FeS_assembly_P PF01883.19 EFX00836.1 - 0.0037 17.4 0.0 0.0074 16.4 0.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Rad54_N PF08658.10 EFX00838.1 - 0.71 10.0 5.9 9.5 6.3 0.2 2.2 2 0 0 2 2 2 0 Rad54 N terminal NIF PF03031.18 EFX00840.1 - 7.4e-55 185.0 0.1 1e-54 184.5 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase CYSTM PF12734.7 EFX00840.1 - 1.8 8.9 10.3 11 6.4 0.1 2.9 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance DUF2076 PF09849.9 EFX00840.1 - 8.4 6.3 15.3 0.18 11.8 0.5 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) LRR_4 PF12799.7 EFX00842.1 - 3.7e-35 119.3 11.7 2.9e-08 33.9 0.3 6.1 6 0 0 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFX00842.1 - 5.1e-24 83.8 18.7 1.6e-06 27.8 0.6 6.3 4 2 0 5 5 5 4 Leucine rich repeat LRR_9 PF14580.6 EFX00842.1 - 3.3e-15 56.0 11.7 2.3e-08 33.8 0.8 4.0 2 1 2 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 EFX00842.1 - 1.3e-05 24.9 15.0 0.62 10.3 0.0 7.1 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.33 EFX00842.1 - 0.00015 21.8 20.6 1.9 9.3 0.1 8.7 10 0 0 10 10 10 2 Leucine Rich Repeat Sugar_tr PF00083.24 EFX00843.1 - 2e-116 389.6 28.8 2.3e-116 389.4 28.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX00843.1 - 1.4e-20 73.6 38.5 1.6e-12 47.1 13.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily 7tm_1 PF00001.21 EFX00843.1 - 0.072 12.4 0.2 0.072 12.4 0.2 2.8 2 1 1 3 3 3 0 7 transmembrane receptor (rhodopsin family) DnaJ PF00226.31 EFX00844.1 - 2.4e-24 85.2 1.0 2.4e-24 85.2 1.0 2.7 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 EFX00844.1 - 1.3e-11 44.4 10.3 3.4e-10 39.9 3.8 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX00844.1 - 6.6e-10 39.0 8.3 1.5e-08 34.8 2.2 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EFX00844.1 - 5.9e-07 29.8 5.4 0.0048 17.6 0.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EFX00844.1 - 2.6e-06 27.7 5.3 0.00018 21.8 0.9 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EFX00844.1 - 9.2e-06 25.8 6.3 0.021 15.3 0.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type Actin_micro PF17003.5 EFX00844.1 - 0.0021 17.3 3.1 0.8 8.8 0.2 2.3 2 0 0 2 2 2 2 Putative actin-like family zf-met2 PF12907.7 EFX00844.1 - 0.035 14.2 0.9 0.035 14.2 0.9 2.3 2 0 0 2 2 2 0 Zinc-binding zf-C2H2_6 PF13912.6 EFX00844.1 - 0.19 11.7 7.1 0.49 10.4 1.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Tmemb_55A PF09788.9 EFX00844.1 - 0.26 10.3 4.2 1.9 7.5 0.6 2.2 2 0 0 2 2 2 0 Transmembrane protein 55A zf-BED PF02892.15 EFX00844.1 - 0.28 11.2 0.8 1.3 9.1 0.1 2.2 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_3rep PF18868.1 EFX00844.1 - 0.34 11.6 5.6 8.2 7.1 0.9 2.7 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats FOXP-CC PF16159.5 EFX00844.1 - 3.9 8.2 8.8 6.2 7.5 0.2 3.2 3 0 0 3 3 2 0 FOXP coiled-coil domain DUF3449 PF11931.8 EFX00844.1 - 4.1 7.2 11.4 1.4 8.7 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3449) Peptidase_C54 PF03416.19 EFX00845.1 - 2.2e-49 168.3 0.0 1.4e-31 110.0 0.0 2.1 1 1 1 2 2 2 2 Peptidase family C54 DEAD PF00270.29 EFX00846.1 - 1.6e-44 151.8 2.2 2.6e-44 151.1 2.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX00846.1 - 2.1e-32 111.8 0.3 8.7e-31 106.5 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX00846.1 - 6.2e-07 29.6 0.0 9.5e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFX00846.1 - 0.00016 21.5 0.2 0.00031 20.5 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX00846.1 - 0.00024 21.5 1.9 0.001 19.4 0.9 2.2 2 1 0 2 2 2 1 AAA domain IL17R_D_N PF16742.5 EFX00846.1 - 0.014 15.4 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D AAA_22 PF13401.6 EFX00846.1 - 0.017 15.4 0.8 0.086 13.1 0.8 2.2 1 1 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 EFX00846.1 - 0.037 13.6 0.4 0.056 13.0 0.3 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 EFX00846.1 - 0.039 13.8 0.0 0.076 12.9 0.0 1.6 1 0 0 1 1 1 0 Helicase CMS1 PF14617.6 EFX00846.1 - 0.042 13.2 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 EFX00846.1 - 0.052 13.5 0.2 0.23 11.4 0.2 2.1 1 1 0 1 1 1 0 Flavivirus DEAD domain tRNA-synt_1b PF00579.25 EFX00846.1 - 0.099 11.9 0.2 0.51 9.6 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) fragilysinNterm PF16376.5 EFX00846.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of fragilysin DSBA PF01323.20 EFX00848.1 - 3.3e-34 118.4 0.0 3.7e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 EFX00848.1 - 0.0014 18.6 0.2 0.028 14.4 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EFX00848.1 - 0.067 13.4 0.0 0.13 12.4 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin APG9 PF04109.16 EFX00849.1 - 3.2e-199 662.9 18.8 3.8e-199 662.7 18.8 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 TMEM154 PF15102.6 EFX00850.1 - 0.00022 21.1 0.1 0.00036 20.5 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.12 EFX00850.1 - 0.0075 16.1 0.4 0.036 13.9 0.1 2.0 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor Sporozoite_P67 PF05642.11 EFX00850.1 - 2.4 6.2 9.9 2.8 5.9 9.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Granulin PF00396.18 EFX00850.1 - 5.1 7.5 16.8 1.5 9.3 4.3 2.4 2 0 0 2 2 2 0 Granulin PALP PF00291.25 EFX00851.1 - 5.1e-58 196.8 3.9 6.3e-58 196.5 3.9 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glu_dehyd_C PF16912.5 EFX00851.1 - 0.054 13.0 0.1 0.094 12.2 0.1 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Piwi PF02171.17 EFX00852.1 - 1.4e-85 287.2 0.0 3.7e-85 285.8 0.0 1.7 2 0 0 2 2 2 1 Piwi domain ArgoN PF16486.5 EFX00852.1 - 2.6e-15 57.3 0.0 7.1e-15 55.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 EFX00852.1 - 1.8e-14 53.8 0.0 4.4e-14 52.5 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 EFX00852.1 - 3.3e-14 52.3 0.2 1.4e-13 50.3 0.2 2.2 1 1 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 EFX00852.1 - 2.9e-10 40.1 0.3 5e-10 39.3 0.3 1.4 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EFX00852.1 - 0.00037 20.7 0.0 0.0012 19.1 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute Fungal_trans PF04082.18 EFX00853.1 - 0.0024 17.0 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain SUIM_assoc PF16619.5 EFX00853.1 - 0.016 15.3 0.3 0.043 13.9 0.3 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Uso1_p115_head PF04869.14 EFX00853.1 - 0.026 13.7 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region F-box-like PF12937.7 EFX00855.1 - 2.3e-10 40.2 0.0 4.2e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX00855.1 - 0.024 14.5 0.0 0.052 13.5 0.0 1.6 1 0 0 1 1 1 0 F-box domain Myb_Cef PF11831.8 EFX00855.1 - 0.12 12.0 0.4 0.22 11.0 0.4 1.3 1 0 0 1 1 1 0 pre-mRNA splicing factor component MFS_1 PF07690.16 EFX00856.1 - 1.7e-21 76.5 24.6 2.6e-21 76.0 24.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily BTB PF00651.31 EFX00858.1 - 6e-07 29.7 0.1 3.2e-06 27.3 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain DUF1656 PF07869.12 EFX00859.1 - 0.11 12.5 3.0 0.2 11.7 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) DUF1746 PF08508.10 EFX00861.1 - 8.2e-28 97.1 3.8 7e-25 87.6 0.0 2.2 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1746) Aldo_ket_red PF00248.21 EFX00862.1 - 1.6e-43 149.0 0.0 2e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Questin_oxidase PF14027.6 EFX00863.1 - 1.5e-73 248.3 0.1 1.7e-73 248.2 0.1 1.0 1 0 0 1 1 1 1 Questin oxidase-like GGACT PF06094.12 EFX00864.1 - 3e-07 31.1 0.0 3.5e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 EFX00864.1 - 0.0062 16.9 0.0 0.026 14.9 0.0 2.0 1 1 0 1 1 1 1 AIG2-like family Asp PF00026.23 EFX00865.1 - 8.1e-112 373.7 0.3 9.5e-112 373.5 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX00865.1 - 8.6e-16 58.7 2.4 1.1e-13 51.8 1.7 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX00865.1 - 0.00011 22.8 0.1 1.3 9.7 0.0 3.7 2 2 1 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 EFX00865.1 - 0.00061 19.6 0.0 0.01 15.6 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EFX00865.1 - 0.0019 18.7 0.0 3.9 8.1 0.0 2.9 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease BolA PF01722.18 EFX00866.1 - 3.9e-19 68.7 0.0 1e-18 67.4 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein GTP_EFTU PF00009.27 EFX00867.1 - 1.5e-44 151.8 0.0 2.2e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EFX00867.1 - 2e-36 125.3 7.2 3.1e-36 124.6 7.2 1.3 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EFX00867.1 - 5e-19 68.3 0.0 1.1e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFX00867.1 - 2.7e-17 62.5 0.0 7.8e-17 61.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFX00867.1 - 8.2e-09 35.7 0.0 1.9e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFX00867.1 - 1.1e-05 25.4 0.0 2.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EFX00867.1 - 0.0016 18.5 0.0 0.0031 17.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FAD_binding_3 PF01494.19 EFX00868.1 - 2.1e-15 56.8 0.0 9.9e-15 54.6 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EFX00868.1 - 5.6e-06 25.6 0.0 0.014 14.5 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase NAD_binding_8 PF13450.6 EFX00868.1 - 0.0024 18.1 0.0 0.0077 16.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX00868.1 - 0.015 14.9 0.1 0.044 13.4 0.1 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX00868.1 - 0.023 13.9 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SDH_alpha PF03313.15 EFX00869.1 - 3.6e-98 328.4 4.6 5e-98 327.9 4.6 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 EFX00869.1 - 2.6e-53 180.5 0.0 6.8e-53 179.2 0.0 1.7 2 0 0 2 2 2 1 Serine dehydratase beta chain TFIID_20kDa PF03847.13 EFX00870.1 - 3e-18 66.1 0.0 5.7e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A SnoaL_2 PF12680.7 EFX00872.1 - 0.00023 21.8 0.3 0.00029 21.4 0.3 1.2 1 0 0 1 1 1 1 SnoaL-like domain CRAL_TRIO PF00650.20 EFX00873.1 - 6.9e-37 126.6 0.0 1.6e-34 118.9 0.0 2.1 2 0 0 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFX00873.1 - 1.4e-07 31.6 1.5 1.9e-07 31.1 0.2 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFX00873.1 - 0.0016 18.6 0.0 0.0034 17.5 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RNA_polI_A34 PF08208.11 EFX00874.1 - 2.3e-44 152.0 6.3 2.3e-44 152.0 6.3 4.1 3 1 0 3 3 3 2 DNA-directed RNA polymerase I subunit RPA34.5 US30 PF17624.2 EFX00874.1 - 0.13 11.2 1.7 0.26 10.3 1.7 1.4 1 0 0 1 1 1 0 Family of unknown function Bromodomain PF00439.25 EFX00876.1 - 1.4e-24 85.9 0.3 2.7e-24 85.0 0.3 1.4 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EFX00876.1 - 4.6e-08 33.3 0.0 9.2e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX00876.1 - 8.6e-07 28.9 0.1 2.2e-06 27.7 0.1 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX00876.1 - 0.00058 20.2 0.1 0.0012 19.2 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Peptidase_M16 PF00675.20 EFX00877.1 - 1.3e-56 190.8 0.5 3.6e-56 189.3 0.5 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFX00877.1 - 1.4e-36 126.3 0.0 2.1e-35 122.4 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 EFX00877.1 - 0.027 13.6 0.1 0.05 12.7 0.1 1.4 1 0 0 1 1 1 0 Peptidase M16C associated RbsD_FucU PF05025.13 EFX00877.1 - 0.034 14.6 0.5 0.21 12.0 0.1 2.4 3 0 0 3 3 3 0 RbsD / FucU transport protein family FliH PF02108.16 EFX00877.1 - 0.035 14.2 0.5 0.89 9.6 0.1 2.9 3 0 0 3 3 3 0 Flagellar assembly protein FliH 2OG-FeII_Oxy PF03171.20 EFX00878.1 - 0.0031 17.9 0.0 0.0055 17.2 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Tim17 PF02466.19 EFX00879.1 - 1.4e-08 35.0 6.6 2.2e-08 34.4 6.6 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MAT1 PF06391.13 EFX00880.1 - 2.6e-35 122.1 0.4 3.4e-35 121.7 0.4 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EFX00880.1 - 5.4e-28 96.6 9.8 8.3e-28 96.0 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX00880.1 - 0.00056 19.7 5.6 0.00084 19.1 5.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MRP-S26 PF14943.6 EFX00880.1 - 0.005 16.8 6.1 0.0086 16.0 6.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 zf-C3HC4 PF00097.25 EFX00880.1 - 0.023 14.6 4.8 0.056 13.3 4.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX00880.1 - 0.044 13.6 5.7 0.12 12.3 5.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX00880.1 - 0.048 13.6 8.4 0.74 9.8 9.2 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EFX00880.1 - 0.076 13.4 5.7 0.15 12.5 5.7 1.4 1 0 0 1 1 1 0 Ring finger domain UQ_con PF00179.26 EFX00881.1 - 1.8e-30 105.4 0.2 2e-17 63.1 0.1 3.1 2 1 0 2 2 2 2 Ubiquitin-conjugating enzyme Acetyltransf_1 PF00583.25 EFX00882.1 - 0.00029 21.0 0.0 0.00041 20.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFX00882.1 - 0.0014 18.6 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EFX00882.1 - 0.0078 15.9 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX00882.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 EFX00883.1 - 9.5e-28 97.1 39.1 9.5e-28 97.1 39.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX00883.1 - 4.5e-10 39.0 5.4 4.5e-10 39.0 5.4 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFX00883.1 - 0.0016 17.0 0.6 0.0027 16.2 0.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CLP1_P PF16575.5 EFX00884.1 - 2.1e-30 106.0 0.0 5.8e-30 104.5 0.0 1.7 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EFX00884.1 - 1.9e-05 25.0 0.0 4.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX00884.1 - 0.0058 16.8 0.0 0.021 15.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX00884.1 - 0.014 15.7 0.0 0.056 13.8 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 EFX00884.1 - 0.034 13.1 0.1 0.064 12.2 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EFX00884.1 - 0.035 13.5 0.0 0.4 10.0 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.6 EFX00884.1 - 0.035 14.6 0.0 0.082 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFX00884.1 - 0.054 13.9 0.0 0.096 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EFX00884.1 - 0.1 13.1 0.5 0.82 10.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 EFX00884.1 - 0.24 11.2 0.3 0.53 10.1 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 EFX00884.1 - 0.27 11.1 0.0 0.45 10.4 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PRP3 PF08572.10 EFX00885.1 - 5.8e-71 238.8 4.9 7.9e-71 238.3 4.9 1.2 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EFX00885.1 - 1.8e-42 144.9 1.7 1.9e-42 144.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) DUF1175 PF06672.11 EFX00885.1 - 0.097 12.3 0.1 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1175) 2-oxoacid_dh PF00198.23 EFX00886.1 - 3.7e-63 213.1 0.1 2.6e-36 125.3 0.0 2.3 1 1 1 2 2 2 2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFX00886.1 - 7.1e-19 67.4 6.5 1.3e-18 66.6 6.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFX00886.1 - 0.00062 19.5 2.9 0.09 12.6 0.4 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 EFX00886.1 - 0.0013 19.4 3.2 0.065 13.9 0.3 2.5 1 1 1 2 2 2 2 HlyD family secretion protein RnfC_N PF13375.6 EFX00886.1 - 0.015 15.3 1.6 0.033 14.1 1.6 1.6 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 EFX00886.1 - 0.034 14.0 1.0 0.067 13.1 1.0 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein Mis14 PF08641.12 EFX00887.1 - 5.6e-13 49.3 2.4 8.1e-13 48.8 1.0 2.0 2 1 0 2 2 2 1 Kinetochore protein Mis14 like Tom22 PF04281.13 EFX00887.1 - 1.5 8.6 4.2 0.84 9.4 2.0 1.8 2 1 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 UPF0203 PF05254.12 EFX00888.1 - 2.5e-26 91.7 7.0 2.9e-26 91.5 7.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 EFX00888.1 - 0.00037 20.8 1.6 0.0023 18.2 1.6 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EFX00888.1 - 0.00046 20.2 4.4 0.023 14.7 0.7 2.3 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 EFX00888.1 - 0.0075 16.5 4.3 0.011 15.9 3.7 1.6 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein NDUF_B7 PF05676.13 EFX00888.1 - 0.031 14.0 3.1 0.83 9.4 0.1 2.2 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF5339 PF17274.2 EFX00888.1 - 0.83 10.6 7.9 2.8 8.9 1.5 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5339) Fig1 PF12351.8 EFX00889.1 - 1.3e-55 188.2 5.9 1.3e-55 188.2 5.9 2.1 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EFX00889.1 - 5.3e-08 32.8 10.9 7.8e-08 32.2 10.9 1.3 1 0 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 EFX00889.1 - 0.0023 17.0 13.3 0.0052 15.9 13.3 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF898) DUF2207 PF09972.9 EFX00889.1 - 0.074 11.8 0.0 0.074 11.8 0.0 2.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) UbiA PF01040.18 EFX00889.1 - 1.8 7.8 22.6 0.41 9.9 1.4 3.1 2 1 0 2 2 2 0 UbiA prenyltransferase family DUF2976 PF11190.8 EFX00889.1 - 2.5 8.0 0.0 2.5 8.0 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2976) Phage_holin_2_4 PF16082.5 EFX00889.1 - 8.7 6.2 5.8 17 5.2 3.1 2.7 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like DnaJ PF00226.31 EFX00890.1 - 5.7e-22 77.6 3.6 2.1e-20 72.6 2.5 2.7 2 0 0 2 2 2 1 DnaJ domain TPR_2 PF07719.17 EFX00890.1 - 9.1e-14 50.4 10.5 0.0031 17.5 0.0 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFX00890.1 - 1.1e-12 47.2 1.4 3.6e-05 23.4 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX00890.1 - 6.2e-12 45.3 9.4 0.0033 18.1 0.0 7.2 2 2 5 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX00890.1 - 8.5e-09 34.9 0.3 0.0073 16.4 0.0 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX00890.1 - 2e-08 34.4 2.9 3.6 8.4 0.0 7.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFX00890.1 - 2.3e-08 33.6 0.0 0.025 14.3 0.1 4.6 4 1 1 5 5 5 2 TPR repeat TPR_19 PF14559.6 EFX00890.1 - 3.8e-08 33.7 9.4 0.011 16.3 0.0 5.0 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFX00890.1 - 1e-07 32.0 3.3 0.0013 18.8 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX00890.1 - 1e-06 28.9 4.9 2.3 8.6 0.0 5.4 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00890.1 - 5.8e-06 26.9 15.7 0.15 12.8 0.7 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFX00890.1 - 1.4e-05 25.1 1.5 0.0022 18.3 0.1 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFX00890.1 - 0.00013 21.8 1.0 3.7 7.8 0.0 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat PknG_TPR PF16918.5 EFX00890.1 - 0.012 14.4 3.0 0.099 11.4 0.7 2.9 3 1 2 5 5 5 0 Protein kinase G tetratricopeptide repeat ANAPC3 PF12895.7 EFX00890.1 - 0.04 14.1 8.5 23 5.3 0.2 5.1 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Fasciclin PF02469.22 EFX00891.1 - 0.02 15.1 0.0 0.048 13.9 0.0 1.6 1 1 0 1 1 1 0 Fasciclin domain Sec34 PF04136.15 EFX00892.1 - 7.7e-50 168.6 1.0 2.1e-49 167.2 0.2 2.1 2 0 0 2 2 2 1 Sec34-like family TrbI PF03743.14 EFX00892.1 - 0.012 15.5 0.1 0.028 14.3 0.1 1.7 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein SKA2 PF16740.5 EFX00892.1 - 0.33 10.7 3.3 4.8 7.0 0.0 3.1 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF3888 PF13027.6 EFX00893.1 - 0.036 14.5 0.1 0.046 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) TMEMspv1-c74-12 PF11044.8 EFX00893.1 - 0.077 13.0 0.2 0.11 12.5 0.2 1.2 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Sel1 PF08238.12 EFX00894.1 - 3.3e-35 119.7 45.0 3.6e-05 24.3 0.2 12.0 11 1 1 12 12 12 9 Sel1 repeat Phage_XkdX PF09693.10 EFX00894.1 - 0.062 13.3 0.1 0.99 9.5 0.1 2.5 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) RCR PF12273.8 EFX00894.1 - 0.33 11.6 2.4 1.9 9.1 0.1 3.2 3 0 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red TLD PF07534.16 EFX00895.1 - 2.3e-27 95.9 0.0 9.8e-15 55.0 0.0 2.1 2 0 0 2 2 2 2 TLD XFP_N PF09364.10 EFX00896.1 - 2e-172 573.0 0.0 2.7e-172 572.6 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 EFX00896.1 - 5.2e-81 270.5 0.0 8e-81 269.9 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 EFX00896.1 - 1.4e-80 269.5 0.0 2e-80 269.0 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain DUF1917 PF08939.10 EFX00897.1 - 4.2e-62 210.4 0.0 7.4e-62 209.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) FA_desaturase PF00487.24 EFX00897.1 - 2.2e-26 93.2 24.1 3.6e-26 92.5 24.1 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFX00897.1 - 8.8e-11 41.8 0.0 1.8e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LPG_synthase_TM PF03706.13 EFX00898.1 - 0.0002 21.0 2.0 0.00032 20.3 2.0 1.3 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region Coatomer_WDAD PF04053.14 EFX00899.1 - 3.6e-141 471.2 0.0 6.1e-141 470.5 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EFX00899.1 - 4.2e-98 328.8 0.0 5.6e-98 328.3 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EFX00899.1 - 4.8e-39 131.6 16.9 5.6e-08 33.3 0.3 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX00899.1 - 9.2e-10 38.7 0.6 0.0028 17.9 0.0 5.7 3 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EFX00899.1 - 0.023 14.6 1.9 0.53 10.1 0.0 3.0 3 0 0 3 3 3 0 Region in Clathrin and VPS Nup160 PF11715.8 EFX00899.1 - 0.064 11.9 6.5 3.9 6.0 0.3 3.7 2 1 2 4 4 4 0 Nucleoporin Nup120/160 TPP_enzyme_N PF02776.18 EFX00900.1 - 2.7e-32 111.7 0.0 4.7e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFX00900.1 - 8.4e-24 83.9 0.0 2.2e-23 82.5 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EFX00900.1 - 5.2e-16 58.8 0.6 9.1e-16 58.0 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Thiolase_N PF00108.23 EFX00901.1 - 4.2e-90 301.6 0.5 4.2e-90 301.6 0.5 1.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFX00901.1 - 7.4e-47 158.0 2.5 1.3e-46 157.2 1.0 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFX00901.1 - 1.6e-05 24.6 0.3 4.6e-05 23.1 0.3 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EFX00901.1 - 0.012 15.4 0.8 0.74 9.7 0.1 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 EFX00902.1 - 5.6e-38 130.8 35.3 9.8e-37 126.7 36.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 EFX00903.1 - 1e-71 241.4 0.0 1.2e-71 241.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00903.1 - 3e-29 102.1 0.0 3.9e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX00903.1 - 2.3e-07 30.4 0.0 2.9e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFX00903.1 - 0.00011 21.2 0.0 0.00017 20.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFX00903.1 - 0.00056 19.9 0.1 0.001 19.0 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFX00903.1 - 0.00058 19.3 0.0 0.00089 18.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AA_permease_2 PF13520.6 EFX00904.1 - 5.4e-28 98.0 22.8 5.4e-28 98.0 22.8 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EFX00904.1 - 4.5e-06 25.5 34.3 6.6e-06 25.0 22.0 2.4 1 1 0 2 2 2 2 Amino acid permease DUF5134 PF17197.4 EFX00904.1 - 0.025 14.5 4.7 0.13 12.1 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) FAD_binding_3 PF01494.19 EFX00905.1 - 4.7e-07 29.4 0.0 7.1e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX00905.1 - 0.0077 15.9 0.1 0.03 13.9 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase DUF1713 PF08213.11 EFX00906.1 - 3.3e-09 36.5 22.3 3.3e-09 36.5 22.3 2.2 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) FlxA PF14282.6 EFX00906.1 - 1.9e-05 24.6 6.1 1.9e-05 24.6 6.1 5.1 4 2 0 4 4 4 1 FlxA-like protein Pet20 PF08692.10 EFX00906.1 - 0.0063 17.2 1.0 0.029 15.1 0.0 2.8 2 2 0 2 2 2 1 Mitochondrial protein Pet20 BUD22 PF09073.10 EFX00906.1 - 9.2 5.5 31.3 2.3 7.4 15.2 2.2 2 0 0 2 2 2 0 BUD22 SSP160 PF06933.11 EFX00907.1 - 6.6 4.8 10.3 8.6 4.4 10.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Rep_fac_C PF08542.11 EFX00908.1 - 1e-22 80.4 0.0 1.9e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EFX00908.1 - 4.5e-15 56.3 0.0 2.1e-14 54.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFX00908.1 - 4e-12 46.2 0.1 7e-07 29.2 0.0 3.1 3 0 0 3 3 3 2 DNA polymerase III, delta subunit Rad17 PF03215.15 EFX00908.1 - 1.7e-09 37.8 0.0 5.1e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_11 PF13086.6 EFX00908.1 - 3.1e-07 30.5 0.0 5.8e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX00908.1 - 1.5e-06 28.7 0.6 0.0009 19.7 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EFX00908.1 - 1.4e-05 24.9 0.0 3.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFX00908.1 - 2.4e-05 24.6 0.1 0.008 16.5 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 EFX00908.1 - 2.6e-05 24.5 0.2 8.9e-05 22.8 0.2 2.0 1 0 0 1 1 1 1 AAA C-terminal domain Mg_chelatase PF01078.21 EFX00908.1 - 0.0009 18.7 0.0 0.028 13.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 EFX00908.1 - 0.0011 19.5 0.0 0.0023 18.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX00908.1 - 0.0012 19.2 0.0 0.0042 17.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFX00908.1 - 0.0022 17.7 0.2 0.012 15.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFX00908.1 - 0.0024 17.9 0.0 0.0055 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EFX00908.1 - 0.0028 17.5 0.0 0.0063 16.3 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF815 PF05673.13 EFX00908.1 - 0.006 15.8 0.0 0.006 15.8 0.0 1.5 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFX00908.1 - 0.0061 16.1 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region TPM_phosphatase PF04536.14 EFX00908.1 - 0.0072 16.5 0.3 0.29 11.3 0.0 2.7 3 0 0 3 3 2 1 TPM domain AAA_30 PF13604.6 EFX00908.1 - 0.012 15.3 0.1 0.082 12.6 0.0 2.3 2 2 1 3 3 2 0 AAA domain AAA_28 PF13521.6 EFX00908.1 - 0.014 15.6 0.0 0.036 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 EFX00908.1 - 0.02 12.8 0.1 0.029 12.3 0.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_5 PF07728.14 EFX00908.1 - 0.022 14.7 0.3 0.2 11.6 0.1 2.6 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFX00908.1 - 0.045 14.3 1.4 0.087 13.4 0.0 2.3 2 2 0 2 2 1 0 AAA domain ResIII PF04851.15 EFX00908.1 - 0.045 13.7 0.2 0.26 11.3 0.0 2.2 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EFX00908.1 - 0.064 13.0 0.1 0.84 9.4 0.0 2.5 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_3 PF07726.11 EFX00908.1 - 0.1 12.5 0.0 0.57 10.1 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Hydin_ADK PF17213.3 EFX00908.1 - 0.13 12.5 2.5 11 6.3 0.0 3.2 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain RNA_helicase PF00910.22 EFX00908.1 - 0.16 12.4 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase MutS_V PF00488.21 EFX00909.1 - 4.5e-83 277.9 0.1 7.4e-83 277.2 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFX00909.1 - 7.9e-37 127.3 1.2 7.9e-37 127.3 1.2 2.2 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 EFX00909.1 - 8.4e-22 77.9 0.1 8.4e-22 77.9 0.1 2.5 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 EFX00909.1 - 4e-18 65.6 1.6 2.8e-17 62.8 0.5 2.8 3 0 0 3 3 3 1 MutS family domain IV MutS_I PF01624.20 EFX00909.1 - 0.017 15.3 0.0 0.12 12.7 0.0 2.3 2 0 0 2 2 2 0 MutS domain I NIF3 PF01784.18 EFX00911.1 - 7e-59 199.4 0.0 8.9e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) MFS_1 PF07690.16 EFX00914.1 - 2e-20 73.0 28.4 1.6e-18 66.8 12.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sm_multidrug_ex PF06695.11 EFX00914.1 - 0.022 15.4 1.4 3.7 8.2 1.4 2.9 2 0 0 2 2 2 0 Putative small multi-drug export protein LETM1 PF07766.13 EFX00915.1 - 1.4e-11 44.3 0.1 4.2e-09 36.1 0.0 2.1 2 0 0 2 2 2 2 LETM1-like protein YbjN PF10722.9 EFX00915.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator Rad1 PF02144.16 EFX00916.1 - 6.2e-68 228.8 0.0 7.2e-68 228.6 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ferric_reduct PF01794.19 EFX00918.1 - 7.8e-21 74.5 9.7 7.8e-21 74.5 9.7 2.4 2 1 1 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFX00918.1 - 1.7e-14 54.2 0.0 2.9e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFX00918.1 - 2e-08 34.3 0.0 5e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFX00918.1 - 9.5e-05 23.0 0.0 0.047 14.3 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain CENP-B_dimeris PF09026.10 EFX00918.1 - 0.25 11.8 7.1 0.57 10.6 7.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EFX00918.1 - 0.67 10.4 6.8 0.22 11.9 3.2 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BDHCT_assoc PF16204.5 EFX00918.1 - 3.8 7.1 4.6 5.8 6.5 4.6 1.2 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein FRG1 PF06229.12 EFX00919.1 - 1e-51 175.4 0.4 1e-51 175.4 0.4 1.4 2 0 0 2 2 2 1 FRG1-like domain LEA_2 PF03168.13 EFX00919.1 - 0.016 15.7 0.1 0.034 14.7 0.1 1.4 1 0 0 1 1 1 0 Late embryogenesis abundant protein Frataxin_Cyay PF01491.16 EFX00919.1 - 0.029 14.4 0.1 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Frataxin-like domain Fascin PF06268.13 EFX00919.1 - 0.048 13.9 0.2 0.22 11.8 0.0 2.2 4 0 0 4 4 4 0 Fascin domain SHMT PF00464.19 EFX00920.1 - 3.1e-210 697.8 0.0 3.6e-210 697.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.19 EFX00920.1 - 0.0073 15.3 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFX00920.1 - 0.033 12.7 0.0 0.055 12.0 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EFX00920.1 - 0.035 13.4 0.0 0.13 11.5 0.0 1.9 1 1 0 1 1 1 0 Beta-eliminating lyase CPSase_L_D2 PF02786.17 EFX00921.1 - 1.2e-109 364.7 0.0 9.2e-84 280.2 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EFX00921.1 - 4.9e-40 136.7 0.0 1.4e-39 135.2 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EFX00921.1 - 6.1e-21 74.7 0.0 1.7e-10 40.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFX00921.1 - 3.2e-18 66.0 0.1 4.6e-09 36.1 0.0 2.3 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EFX00921.1 - 9.9e-10 38.3 0.0 0.0012 18.6 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 EFX00921.1 - 3.5e-05 23.4 0.3 0.14 11.6 0.1 2.7 2 1 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 EFX00921.1 - 3.9e-05 23.5 0.1 0.069 12.9 0.1 2.6 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 EFX00921.1 - 8e-05 22.7 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain NAPRTase PF04095.16 EFX00922.1 - 6.5e-57 192.9 0.0 2.3e-55 187.8 0.0 2.1 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EFX00922.1 - 1.7e-35 122.1 0.0 4.5e-35 120.8 0.0 1.8 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Evr1_Alr PF04777.13 EFX00923.1 - 1.9e-30 105.3 0.6 4e-30 104.2 0.2 1.7 2 0 0 2 2 2 1 Erv1 / Alr family TetR_C_33 PF13305.6 EFX00923.1 - 0.06 14.1 2.1 0.098 13.4 2.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain FSA_C PF10479.9 EFX00923.1 - 0.088 10.9 3.5 0.093 10.9 3.5 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FAD_binding_4 PF01565.23 EFX00925.1 - 1.6e-18 66.7 0.6 5.7e-16 58.5 0.6 2.5 1 1 0 1 1 1 1 FAD binding domain ALO PF04030.14 EFX00925.1 - 1.3e-14 54.7 0.0 1.8e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase SIS_2 PF13580.6 EFX00925.1 - 0.098 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 SIS domain COQ9 PF08511.11 EFX00927.1 - 7.6e-30 102.5 0.1 1.3e-29 101.8 0.1 1.4 1 0 0 1 1 1 1 COQ9 ABC_membrane_2 PF06472.15 EFX00928.1 - 1.6e-89 299.9 3.2 1.7e-88 296.6 0.1 2.4 3 0 0 3 3 3 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFX00928.1 - 3.8e-15 56.6 0.0 8.3e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter THOC7 PF05615.13 EFX00928.1 - 0.043 14.1 1.7 0.11 12.8 0.9 1.9 2 0 0 2 2 2 0 Tho complex subunit 7 End3 PF12761.7 EFX00928.1 - 0.058 13.6 0.9 0.66 10.1 0.5 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 AAA_29 PF13555.6 EFX00928.1 - 0.063 13.0 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EFX00928.1 - 0.067 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFX00928.1 - 0.12 12.9 6.5 2 8.9 6.5 2.3 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 EFX00928.1 - 0.13 11.7 0.0 3 7.2 0.1 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Histone PF00125.24 EFX00929.1 - 1e-21 77.6 2.1 1.3e-21 77.4 2.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFX00929.1 - 4.2e-05 23.8 0.0 0.0001 22.5 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EFX00929.1 - 0.00033 21.1 0.0 0.00056 20.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 EFX00929.1 - 0.017 14.7 0.1 0.043 13.5 0.1 1.6 1 1 0 1 1 1 0 Replication protein C N-terminal domain 2OG-FeII_Oxy PF03171.20 EFX00930.1 - 6.7e-14 52.2 0.0 1.1e-13 51.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFX00930.1 - 1e-08 35.9 0.0 1.7e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal SGT1 PF07093.11 EFX00931.1 - 7.8e-11 41.1 9.7 8.8e-05 21.1 6.2 3.1 2 1 0 2 2 2 2 SGT1 protein IBR PF01485.21 EFX00932.1 - 2.4e-06 27.7 5.6 2.4e-06 27.7 5.6 4.0 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain Bromodomain PF00439.25 EFX00934.1 - 5e-19 68.2 0.0 1.2e-18 67.0 0.0 1.7 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EFX00934.1 - 5.8e-10 39.0 0.2 1.4e-09 37.8 0.2 1.6 1 0 0 1 1 1 1 Bromodomain associated NAD_binding_10 PF13460.6 EFX00935.1 - 2.5e-12 47.1 0.0 3.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFX00935.1 - 0.00064 19.4 0.0 0.0015 18.1 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.24 EFX00935.1 - 0.019 15.4 0.0 0.033 14.6 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EFX00935.1 - 0.059 12.4 0.0 0.086 11.8 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFX00935.1 - 0.16 11.1 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein tRNA-synt_2d PF01409.20 EFX00936.1 - 3.2e-85 285.5 0.0 4.7e-85 285.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EFX00936.1 - 1.7e-15 57.0 2.1 2.7e-15 56.4 1.0 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EFX00936.1 - 2e-05 24.2 0.0 0.046 13.2 0.0 2.5 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 EFX00936.1 - 4.7e-05 22.6 0.0 0.0042 16.2 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 EFX00936.1 - 0.00062 19.7 0.9 0.0018 18.2 0.9 1.9 1 0 0 1 1 1 1 PheRS DNA binding domain 2 RelE PF06296.12 EFX00936.1 - 0.083 13.0 2.4 0.5 10.5 2.4 2.2 1 1 0 1 1 1 0 RelE toxin of RelE / RelB toxin-antitoxin system Drc1-Sld2 PF11719.8 EFX00937.1 - 1.2e-89 301.9 19.6 1.5e-89 301.6 19.6 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein TFIIF_alpha PF05793.12 EFX00937.1 - 6.6 5.2 30.4 0.062 11.9 3.5 2.8 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MBOAT PF03062.19 EFX00939.1 - 8.3e-47 160.2 21.4 1.5e-46 159.4 21.4 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Sec61_beta PF03911.16 EFX00940.1 - 3.6e-19 68.5 1.9 4.8e-19 68.1 1.9 1.2 1 0 0 1 1 1 1 Sec61beta family DUF1180 PF06679.12 EFX00940.1 - 0.5 10.8 7.1 0.83 10.0 7.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) CAP_N PF01213.19 EFX00940.1 - 8.3 5.8 7.4 9.5 5.6 7.4 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RMI1_N PF08585.12 EFX00941.1 - 1.2e-55 188.6 0.0 1.4e-55 188.4 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein Sec66 PF09802.9 EFX00942.1 - 2.1e-77 258.8 0.0 2.5e-77 258.5 0.0 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 PEP-utilisers_N PF05524.13 EFX00942.1 - 0.003 17.7 1.3 0.0049 17.0 0.9 1.5 1 1 0 1 1 1 1 PEP-utilising enzyme, N-terminal Sin3a_C PF16879.5 EFX00943.1 - 5.9e-75 252.6 0.9 5.9e-75 252.6 0.9 3.0 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 EFX00943.1 - 5.3e-45 151.3 2.1 2.7e-18 65.8 1.7 3.9 3 1 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EFX00943.1 - 1.2e-37 127.9 0.0 3.8e-37 126.3 0.0 2.0 1 0 0 1 1 1 1 Sin3 family co-repressor Pollen_allerg_1 PF01357.21 EFX00943.1 - 0.15 12.1 0.2 3.7 7.7 0.3 2.5 2 0 0 2 2 2 0 Pollen allergen CDC45 PF02724.14 EFX00943.1 - 0.19 10.0 11.9 0.71 8.1 7.9 2.3 2 0 0 2 2 2 0 CDC45-like protein TPR_16 PF13432.6 EFX00944.1 - 2.9e-20 72.6 56.6 4.9e-08 33.5 1.0 11.5 10 2 2 12 12 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFX00944.1 - 4.6e-18 64.4 37.4 0.049 14.5 0.0 14.4 10 4 4 14 14 14 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFX00944.1 - 4.5e-16 59.1 34.1 4.8e-05 23.8 1.6 11.8 12 1 1 13 13 12 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFX00944.1 - 3.3e-14 51.8 17.6 0.24 11.7 0.0 11.4 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFX00944.1 - 6.1e-14 50.9 38.3 0.19 11.9 0.1 14.0 14 0 0 14 14 14 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFX00944.1 - 1.9e-12 46.4 27.1 0.15 12.0 0.1 11.6 12 1 0 12 12 11 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFX00944.1 - 1.4e-09 37.3 14.9 0.0042 17.0 0.0 9.9 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFX00944.1 - 4.2e-07 29.6 20.0 0.079 12.7 0.0 8.4 9 1 1 10 10 9 2 TPR repeat TPR_12 PF13424.6 EFX00944.1 - 1.5e-05 25.2 55.7 0.067 13.5 0.1 13.7 13 4 2 15 15 14 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX00944.1 - 1.6e-05 25.1 1.4 1.2 9.5 0.1 6.2 6 1 0 6 6 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFX00944.1 - 2.2e-05 24.5 5.5 1.2e+02 3.4 0.0 10.5 12 1 1 13 13 12 0 Tetratricopeptide repeat TPR_22 PF18833.1 EFX00944.1 - 0.00097 19.2 0.0 0.0045 17.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3856 PF12968.7 EFX00944.1 - 0.0033 17.5 9.0 1.3 9.1 0.5 5.3 4 1 0 4 4 4 1 Domain of Unknown Function (DUF3856) TPR_10 PF13374.6 EFX00944.1 - 0.012 15.5 17.6 0.23 11.4 0.2 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat ChAPs PF09295.10 EFX00944.1 - 0.027 13.5 0.0 2.5 7.0 0.0 3.3 4 0 0 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) RNA_pol_3_Rpc31 PF11705.8 EFX00944.1 - 0.034 14.4 3.0 0.071 13.4 3.0 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 EFX00944.1 - 0.041 13.6 3.3 0.094 12.4 3.3 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TPR_5 PF12688.7 EFX00944.1 - 0.057 13.7 2.3 25 5.1 0.0 4.5 4 1 1 5 5 5 0 Tetratrico peptide repeat RdRP_5 PF07925.11 EFX00944.1 - 0.21 8.9 0.0 0.3 8.4 0.0 1.1 1 0 0 1 1 1 0 Reovirus RNA-dependent RNA polymerase lambda 3 TPR_6 PF13174.6 EFX00944.1 - 1.2 9.9 26.9 27 5.7 0.1 10.3 13 0 0 13 13 10 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFX00944.1 - 3.6 7.7 13.6 16 5.7 0.2 6.0 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat MIF4G PF02854.19 EFX00945.1 - 5.9e-16 58.7 0.0 2.2e-15 56.9 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 EFX00945.1 - 6.3e-13 48.7 0.0 3.6e-12 46.3 0.0 2.3 1 1 0 1 1 1 1 MA3 domain E7 PF00527.18 EFX00945.1 - 1.5 9.1 3.6 9.6 6.5 0.0 3.4 3 0 0 3 3 3 0 E7 protein, Early protein adh_short_C2 PF13561.6 EFX00946.1 - 1.1e-55 188.8 1.0 1.5e-55 188.3 1.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX00946.1 - 3.6e-46 157.1 0.7 4.8e-46 156.7 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX00946.1 - 6e-10 39.3 0.2 7.9e-10 38.9 0.2 1.1 1 0 0 1 1 1 1 KR domain Methyltransf_11 PF08241.12 EFX00946.1 - 0.075 13.7 0.2 1.4 9.7 0.2 2.6 1 1 0 1 1 1 0 Methyltransferase domain FRQ PF09421.10 EFX00947.1 - 1.2e-245 818.1 53.8 1.2e-245 818.0 50.8 2.1 1 1 0 1 1 1 1 Frequency clock protein tRNA-synt_2c PF01411.19 EFX00948.1 - 1.9e-210 700.1 0.0 2.6e-210 699.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFX00948.1 - 3.3e-17 62.3 0.6 9e-17 60.9 0.6 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EFX00948.1 - 1.2e-10 41.9 1.2 1.2e-10 41.9 1.2 2.6 4 0 0 4 4 4 1 DHHA1 domain RINT1_TIP1 PF04437.13 EFX00949.1 - 2.7e-146 488.4 0.0 3.6e-146 488.0 0.0 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family DNA_pol_A_exo1 PF01612.20 EFX00949.1 - 7e-40 136.6 0.2 1.5e-39 135.5 0.2 1.6 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EFX00949.1 - 2.7e-26 92.1 1.6 8.3e-26 90.5 1.6 1.9 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 EFX00949.1 - 7.1e-09 35.5 0.1 2.1e-08 34.0 0.1 1.8 1 0 0 1 1 1 1 HRDC domain CRISPR_Cse2 PF09485.10 EFX00949.1 - 0.01 16.4 7.3 0.01 16.4 7.3 3.7 3 0 0 3 3 3 0 CRISPR-associated protein Cse2 (CRISPR_cse2) BTB PF00651.31 EFX00950.1 - 0.0049 17.1 0.0 0.0088 16.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain SMC_N PF02463.19 EFX00951.1 - 1e-19 70.9 9.6 5.2e-19 68.5 9.7 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFX00951.1 - 7.3e-18 65.8 0.9 7.3e-18 65.8 0.9 4.8 3 2 1 4 4 4 1 AAA domain AAA_15 PF13175.6 EFX00951.1 - 2.3e-09 37.5 3.0 2.3e-09 37.5 3.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain SMC_hinge PF06470.13 EFX00951.1 - 1.4e-05 25.3 0.0 6e-05 23.3 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFX00951.1 - 1.6e-05 24.9 5.6 0.00026 20.9 0.1 3.6 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFX00951.1 - 0.0011 18.7 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 EFX00951.1 - 0.0026 18.0 0.0 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Toxin_trans PF07952.12 EFX00951.1 - 0.021 13.9 0.1 0.021 13.9 0.1 2.3 2 0 0 2 2 2 0 Clostridium neurotoxin, Translocation domain ABC_tran PF00005.27 EFX00951.1 - 0.11 13.0 0.2 0.11 13.0 0.2 5.9 5 1 0 5 5 5 0 ABC transporter Treacle PF03546.14 EFX00952.1 - 0.05 12.4 0.4 0.079 11.8 0.4 1.3 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle tRNA_m1G_MT PF01746.21 EFX00953.1 - 1.2e-28 100.2 0.1 7e-26 91.1 0.1 2.3 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase NARP1 PF12569.8 EFX00953.1 - 3.1 6.6 7.6 5.6 5.8 7.6 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4187 PF13821.6 EFX00954.1 - 3.2e-19 68.5 0.7 7.7e-19 67.2 0.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EFX00954.1 - 5.1e-10 39.1 0.5 2.4e-09 36.9 0.5 2.1 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFX00954.1 - 0.00012 22.1 0.4 0.00043 20.3 0.4 2.0 1 0 0 1 1 1 1 G-patch domain AAA PF00004.29 EFX00955.1 - 2.3e-45 154.3 0.1 6.5e-45 152.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFX00955.1 - 7e-10 38.7 0.5 4e-09 36.3 0.0 2.4 3 0 0 3 3 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EFX00955.1 - 1.8e-08 34.5 0.4 6.6e-08 32.6 0.1 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFX00955.1 - 5.3e-08 33.2 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFX00955.1 - 1.3e-07 32.2 0.1 3.7e-05 24.2 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EFX00955.1 - 4.1e-06 26.2 0.0 8.2e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFX00955.1 - 3.8e-05 24.0 0.9 0.0088 16.3 0.1 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EFX00955.1 - 0.00024 20.9 0.0 0.00071 19.4 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFX00955.1 - 0.00047 20.7 0.0 0.0012 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFX00955.1 - 0.00063 20.0 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFX00955.1 - 0.00085 18.9 0.1 0.0032 17.0 0.1 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_3 PF17862.1 EFX00955.1 - 0.0013 18.5 0.0 0.0031 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 EFX00955.1 - 0.0013 18.0 0.0 0.0025 17.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_30 PF13604.6 EFX00955.1 - 0.0018 18.1 0.0 0.0042 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFX00955.1 - 0.0018 18.3 0.3 0.0078 16.3 0.0 2.1 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 EFX00955.1 - 0.0022 18.3 0.0 0.0046 17.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EFX00955.1 - 0.0039 17.1 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_3 PF07726.11 EFX00955.1 - 0.0056 16.6 0.0 0.018 14.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EFX00955.1 - 0.0058 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EFX00955.1 - 0.0071 15.7 0.2 0.016 14.6 0.1 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFX00955.1 - 0.0087 16.2 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EFX00955.1 - 0.01 15.8 0.2 0.12 12.3 0.0 2.3 1 1 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 EFX00955.1 - 0.012 15.4 0.1 0.028 14.2 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein TniB PF05621.11 EFX00955.1 - 0.014 14.8 0.0 0.51 9.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 EFX00955.1 - 0.021 14.6 0.2 0.055 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EFX00955.1 - 0.029 13.7 1.1 0.52 9.6 0.0 2.6 3 0 0 3 3 3 0 KaiC Bac_DnaA PF00308.18 EFX00955.1 - 0.041 13.7 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 EFX00955.1 - 0.043 13.7 1.0 0.34 10.8 0.0 2.5 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EFX00955.1 - 0.053 13.3 0.1 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFX00955.1 - 0.059 12.9 1.0 0.23 11.0 0.1 2.2 2 1 1 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EFX00955.1 - 0.061 13.0 0.1 1.2 8.8 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFX00955.1 - 0.086 12.1 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Viral_Hsp90 PF03225.14 EFX00955.1 - 0.093 11.2 0.0 0.15 10.5 0.0 1.3 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue AAA_19 PF13245.6 EFX00955.1 - 0.12 12.7 0.1 0.37 11.1 0.1 1.8 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFX00955.1 - 0.14 11.7 0.0 0.35 10.5 0.0 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EFX00955.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Parvo_NS1 PF01057.17 EFX00955.1 - 0.2 10.7 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Pyr_redox_2 PF07992.14 EFX00956.1 - 1.7e-68 231.0 3.6 6.2e-68 229.2 3.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFX00956.1 - 1.1e-41 141.5 0.0 2.5e-41 140.4 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFX00956.1 - 9.3e-23 80.6 8.0 2.4e-20 72.9 0.2 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX00956.1 - 3.8e-10 39.9 4.3 8.2e-06 26.0 1.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFX00956.1 - 4.2e-09 36.3 8.8 1.2e-08 34.8 0.8 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 EFX00956.1 - 1.1e-08 34.5 8.2 8.3e-07 28.4 4.3 2.5 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EFX00956.1 - 1.2e-07 31.2 10.9 4.7e-07 29.2 4.1 3.2 4 0 0 4 4 4 1 FAD binding domain AlaDh_PNT_C PF01262.21 EFX00956.1 - 1e-06 28.2 1.7 0.03 13.6 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EFX00956.1 - 3.3e-06 26.5 3.3 6e-05 22.4 0.4 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EFX00956.1 - 4.8e-05 23.1 10.7 0.0056 16.3 0.8 3.7 3 1 1 4 4 4 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EFX00956.1 - 5.2e-05 22.1 13.1 0.00028 19.7 2.8 3.9 4 0 0 4 4 4 1 HI0933-like protein Pyr_redox_3 PF13738.6 EFX00956.1 - 5.3e-05 22.6 3.7 0.051 12.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFX00956.1 - 0.00014 21.3 4.0 0.067 12.4 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.6 EFX00956.1 - 0.0003 20.0 0.2 0.023 13.9 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EFX00956.1 - 0.025 13.6 6.0 0.052 12.6 0.9 2.5 2 1 0 2 2 2 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 EFX00956.1 - 0.089 13.2 1.2 9.6 6.7 0.1 3.1 3 0 0 3 3 3 0 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 EFX00956.1 - 0.13 11.6 0.0 9.2 5.6 0.0 3.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EFX00956.1 - 0.99 9.3 4.9 0.88 9.4 0.1 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 EFX00956.1 - 3.2 6.5 6.5 0.56 9.0 1.6 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Zn_clus PF00172.18 EFX00957.1 - 4.4e-07 29.9 10.3 7.5e-07 29.2 10.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Presenilin PF01080.17 EFX00957.1 - 0.00033 19.5 19.0 0.017 13.9 2.5 2.3 2 0 0 2 2 2 2 Presenilin SAPS PF04499.15 EFX00957.1 - 0.00054 18.9 6.3 0.052 12.3 0.3 2.2 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein DUF2722 PF10846.8 EFX00957.1 - 0.0011 18.1 19.1 0.0011 18.1 19.1 4.0 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 EFX00957.1 - 0.0016 18.6 9.4 0.0016 18.6 9.4 3.3 2 1 0 2 2 1 1 Transcription factor IIA, alpha/beta subunit Spore_coat_CotO PF14153.6 EFX00957.1 - 0.003 17.5 4.4 0.003 17.5 4.4 3.4 3 0 0 3 3 2 1 Spore coat protein CotO EOS1 PF12326.8 EFX00957.1 - 0.0094 15.9 3.0 0.63 10.0 0.1 2.4 2 0 0 2 2 2 1 N-glycosylation protein EPL1 PF10513.9 EFX00957.1 - 0.072 13.5 22.8 0.28 11.5 6.4 3.2 3 0 0 3 3 3 0 Enhancer of polycomb-like CFIA_Pcf11 PF11526.8 EFX00957.1 - 0.079 13.5 21.1 20 5.7 0.0 3.5 3 0 0 3 3 3 0 Subunit of cleavage factor IA Pcf11 DUF702 PF05142.12 EFX00957.1 - 0.082 13.4 22.4 0.36 11.3 5.9 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF4820 PF16091.5 EFX00957.1 - 0.088 12.2 19.4 0.068 12.5 4.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) GPCR_chapero_1 PF11904.8 EFX00957.1 - 0.17 11.3 6.3 5.3 6.4 2.2 2.4 2 0 0 2 2 2 0 GPCR-chaperone DUF4746 PF15928.5 EFX00957.1 - 0.23 10.8 14.7 1.7 8.0 5.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 EFX00957.1 - 0.27 10.2 25.6 0.079 11.9 7.4 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4471 PF14740.6 EFX00957.1 - 0.3 10.2 9.2 1.5 8.0 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PA26 PF04636.13 EFX00957.1 - 0.33 9.8 6.9 2.4 7.0 1.2 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) AAR2 PF05282.11 EFX00957.1 - 0.56 9.6 8.0 2.3 7.5 1.7 2.5 2 0 0 2 2 2 0 AAR2 protein DAG_kinase_N PF14513.6 EFX00957.1 - 0.68 10.1 15.5 4.1 7.6 1.8 2.5 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus SLC12 PF03522.15 EFX00957.1 - 0.88 8.5 15.3 0.63 9.0 3.8 2.4 2 0 0 2 2 2 0 Solute carrier family 12 SID-1_RNA_chan PF13965.6 EFX00957.1 - 1.6 7.0 3.3 3.8 5.8 0.2 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF4175 PF13779.6 EFX00957.1 - 1.7 6.4 47.7 0.059 11.3 7.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4175) ASD2 PF08687.11 EFX00957.1 - 1.8 8.0 21.1 0.78 9.2 6.9 2.6 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 TCP PF03634.13 EFX00957.1 - 2.3 8.7 21.1 0.62 10.6 3.8 2.7 3 0 0 3 3 2 0 TCP family transcription factor NARP1 PF12569.8 EFX00957.1 - 2.5 6.9 18.5 0.29 10.0 1.2 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 FAM60A PF15396.6 EFX00957.1 - 2.6 8.0 15.6 7 6.6 1.9 2.5 2 0 0 2 2 2 0 Protein Family FAM60A PIP5K PF01504.18 EFX00957.1 - 2.6 7.2 13.5 1.1 8.5 2.8 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase CDC45 PF02724.14 EFX00957.1 - 3.1 6.0 12.7 2.2 6.5 0.6 2.1 2 0 0 2 2 2 0 CDC45-like protein NPR3 PF03666.13 EFX00957.1 - 4.4 6.0 17.6 1.3 7.7 2.5 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Cnd2 PF05786.14 EFX00957.1 - 5.6 5.5 15.6 2.3 6.8 2.5 2.2 2 0 0 2 2 2 0 Condensin complex subunit 2 CPSF100_C PF13299.6 EFX00957.1 - 6.2 7.0 23.0 2 8.6 6.7 3.0 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal PAT1 PF09770.9 EFX00957.1 - 6.5 4.9 40.9 0.72 8.1 5.8 2.4 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 EIIBC-GUT_N PF03612.14 EFX00957.1 - 7 6.4 20.2 0.65 9.7 6.3 2.5 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AAA_23 PF13476.6 EFX00957.1 - 8.4 6.8 20.4 0.2 12.2 5.6 2.6 3 0 0 3 3 2 0 AAA domain Pal1 PF08316.11 EFX00957.1 - 9.5 7.0 16.6 2.8 8.7 2.8 3.1 3 0 0 3 3 3 0 Pal1 cell morphology protein Mannosyl_trans3 PF11051.8 EFX00958.1 - 1.3e-35 123.1 0.0 6e-35 120.9 0.0 1.9 1 1 0 1 1 1 1 Mannosyltransferase putative DUF4448 PF14610.6 EFX00959.1 - 2.2e-46 158.0 0.0 3.1e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Pkinase PF00069.25 EFX00960.1 - 3.3e-68 229.9 0.0 4.4e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00960.1 - 5.4e-32 111.1 0.0 7.1e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFX00960.1 - 0.0004 19.8 0.3 0.00067 19.1 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFX00960.1 - 0.0014 17.7 0.4 0.0027 16.7 0.4 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFX00960.1 - 0.0083 15.5 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFX00960.1 - 0.026 14.5 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFX00960.1 - 0.074 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.11 EFX00960.1 - 0.098 12.9 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Gag protein p6 S_100 PF01023.19 EFX00960.1 - 0.13 12.0 0.2 0.38 10.5 0.2 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Gpi1 PF05024.15 EFX00961.1 - 7.7e-79 264.1 6.7 1.3e-78 263.3 6.7 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) 7tm_1 PF00001.21 EFX00961.1 - 4.4e-05 22.9 0.9 9.4e-05 21.9 0.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cys_Met_Meta_PP PF01053.20 EFX00962.1 - 3.8e-24 84.9 0.0 1.4e-23 83.1 0.0 1.8 2 1 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Folliculin PF11704.8 EFX00963.1 - 4.9e-60 202.6 0.9 2.5e-59 200.3 0.0 2.4 3 0 0 3 3 3 1 Vesicle coat protein involved in Golgi to plasma membrane transport TFIIA PF03153.13 EFX00964.1 - 0.0031 17.6 10.5 0.005 16.9 10.5 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Metallophos PF00149.28 EFX00965.1 - 8.9e-10 39.4 0.1 1.7e-09 38.5 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Mito_carr PF00153.27 EFX00966.1 - 4.9e-54 180.2 1.6 6.8e-22 77.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L18A PF01775.17 EFX00968.1 - 4.1e-55 185.1 0.2 5.2e-55 184.7 0.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Sec63 PF02889.16 EFX00969.1 - 4e-145 481.7 0.0 9.7e-86 287.1 0.0 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFX00969.1 - 3.7e-46 157.1 0.0 5.2e-27 94.7 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EFX00969.1 - 1.6e-32 112.0 0.4 3.9e-32 110.7 0.4 1.7 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EFX00969.1 - 5.5e-20 72.0 0.0 1.1e-12 48.3 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PWWP PF00855.17 EFX00969.1 - 2.4e-14 53.5 0.0 1e-13 51.5 0.0 2.2 1 0 0 1 1 1 1 PWWP domain Helicase_C PF00271.31 EFX00969.1 - 6.2e-10 39.4 0.0 2.7e-07 30.9 0.0 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFX00969.1 - 0.00022 21.5 2.9 0.011 16.0 0.1 3.7 3 2 0 3 3 3 1 AAA domain T2SSE PF00437.20 EFX00969.1 - 0.0033 16.5 0.1 2.8 6.9 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein Med26 PF08711.11 EFX00969.1 - 0.021 14.8 0.7 0.071 13.1 0.5 2.2 2 0 0 2 2 2 0 TFIIS helical bundle-like domain UvrD-helicase PF00580.21 EFX00969.1 - 0.023 14.2 2.2 6.9 6.1 0.1 3.2 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain MU2_FHA PF18221.1 EFX00969.1 - 0.027 14.5 0.2 0.1 12.6 0.1 2.0 2 0 0 2 2 2 0 Mutator 2 Fork head associated domain DUF3335 PF11814.8 EFX00969.1 - 0.097 12.1 0.0 0.74 9.3 0.0 2.5 3 0 0 3 3 3 0 Peptidase_C39 like family Epimerase PF01370.21 EFX00970.1 - 8.5e-11 41.8 0.1 0.00021 20.9 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFX00970.1 - 9.4e-08 32.2 0.1 2e-07 31.1 0.1 1.5 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFX00970.1 - 9.7e-05 21.9 0.0 0.0013 18.2 0.0 2.4 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 EFX00970.1 - 0.00036 20.9 0.4 0.0017 18.8 0.1 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFX00970.1 - 0.0006 20.1 0.6 0.0024 18.1 0.0 2.1 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EFX00970.1 - 0.14 11.3 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Y_phosphatase PF00102.27 EFX00972.1 - 4.3e-46 157.4 0.1 7.4e-22 78.1 0.0 3.1 2 1 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFX00972.1 - 0.0045 17.1 0.0 0.0094 16.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 EFX00972.1 - 0.019 14.8 0.0 0.051 13.4 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFX00972.1 - 0.055 13.4 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family RasGAP_C PF03836.15 EFX00973.1 - 0.15 12.2 10.1 0.065 13.4 6.5 2.3 2 0 0 2 2 2 0 RasGAP C-terminus PKcGMP_CC PF16808.5 EFX00973.1 - 2.5 8.0 9.4 0.49 10.3 4.6 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Fib_alpha PF08702.10 EFX00973.1 - 8.8 6.5 17.5 0.66 10.1 3.0 3.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SPX PF03105.19 EFX00974.1 - 2.5 7.9 5.6 1.5 8.7 4.1 1.4 1 1 0 1 1 1 0 SPX domain ANTH PF07651.16 EFX00975.1 - 1.2e-64 218.0 0.2 1.5e-64 217.7 0.2 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EFX00975.1 - 9.5e-05 22.4 0.0 0.00021 21.4 0.0 1.6 1 1 0 1 1 1 1 ENTH domain Med9 PF07544.13 EFX00976.1 - 3.3e-11 43.1 0.6 4.7e-11 42.6 0.6 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 ACT_4 PF13291.6 EFX00976.1 - 0.024 15.2 0.0 0.032 14.8 0.0 1.1 1 0 0 1 1 1 0 ACT domain SlyX PF04102.12 EFX00976.1 - 0.083 13.5 2.9 0.11 13.1 2.9 1.3 1 0 0 1 1 1 0 SlyX IFT20 PF14931.6 EFX00976.1 - 0.1 12.8 2.2 0.13 12.5 2.2 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Glyco_hydro_5_C PF18564.1 EFX00978.1 - 2.3e-16 60.1 0.0 5.1e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EFX00978.1 - 2.2e-12 47.0 0.7 7.4e-08 32.1 0.8 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 EFX00978.1 - 0.008 15.8 0.1 0.014 15.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 zf-RING_2 PF13639.6 EFX00979.1 - 2.7e-08 34.0 10.4 5.4e-08 33.0 10.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFX00979.1 - 1.8e-06 27.7 7.2 3e-06 27.0 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX00979.1 - 5.7e-06 26.1 9.6 1e-05 25.3 9.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX00979.1 - 1.8e-05 24.5 5.7 2.9e-05 23.9 5.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFX00979.1 - 0.02 15.2 10.4 0.1 12.9 10.4 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFX00979.1 - 1.4 8.9 8.0 2.7 7.9 8.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EFX00979.1 - 2 8.2 5.7 4.7 7.0 5.7 1.6 1 0 0 1 1 1 0 RING-like zinc finger Mannosyl_trans3 PF11051.8 EFX00980.1 - 3.9e-35 121.5 0.0 2.1e-34 119.2 0.0 2.0 1 1 0 1 1 1 1 Mannosyltransferase putative DAGK_cat PF00781.24 EFX00980.1 - 0.19 11.4 0.0 0.44 10.2 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Ribosomal_S17 PF00366.20 EFX00981.1 - 2e-21 75.8 1.1 3.7e-21 75.0 1.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Presenilin PF01080.17 EFX00981.1 - 0.051 12.3 0.3 0.088 11.6 0.3 1.4 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 EFX00981.1 - 4.4 5.6 17.5 8.7 4.6 17.5 1.4 1 0 0 1 1 1 0 Menin PCI PF01399.27 EFX00984.1 - 1.2e-12 48.2 0.0 3e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 EFX00984.1 - 0.19 11.9 2.5 0.24 11.6 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_47 PF01532.20 EFX00985.1 - 1.3e-176 588.0 0.0 1.5e-176 587.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Unpaired PF15972.5 EFX00986.1 - 0.025 14.1 0.5 0.033 13.7 0.5 1.1 1 0 0 1 1 1 0 Unpaired protein SUIM_assoc PF16619.5 EFX00986.1 - 0.033 14.2 4.1 0.071 13.2 4.1 1.6 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Nrap_D4 PF17405.2 EFX00987.1 - 1.1e-58 198.1 1.2 1.8e-58 197.4 1.2 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EFX00987.1 - 7.6e-56 188.3 0.0 4.9e-55 185.7 0.0 2.1 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 EFX00987.1 - 9.3e-48 162.1 0.6 1.6e-47 161.4 0.6 1.4 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D2 PF17403.2 EFX00987.1 - 2.3e-46 157.3 0.1 1.3e-41 141.9 0.0 2.7 3 0 0 3 3 3 2 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 EFX00987.1 - 4.5e-46 156.8 0.0 1.9e-45 154.8 0.0 2.0 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EFX00987.1 - 1.1e-36 126.1 0.0 2.3e-35 121.8 0.0 2.4 2 0 0 2 2 2 1 Nrap protein domain 6 Rpn3_C PF08375.11 EFX00988.1 - 3e-26 91.6 1.7 8.1e-26 90.2 1.7 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EFX00988.1 - 1.5e-20 73.6 0.1 5.3e-20 71.9 0.0 2.0 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 EFX00988.1 - 0.0035 17.3 0.1 0.016 15.2 0.1 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX00988.1 - 0.15 12.7 1.3 0.81 10.4 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat Metallophos PF00149.28 EFX00989.1 - 5.8e-17 62.9 0.5 1.1e-16 62.0 0.5 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFX00989.1 - 6.1e-06 26.5 0.0 6.3e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Cation_ATPase_C PF00689.21 EFX00990.1 - 3e-45 154.2 8.4 3e-45 154.2 8.4 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFX00990.1 - 1.3e-34 119.3 0.8 1.3e-34 119.3 0.8 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFX00990.1 - 5.5e-19 69.3 1.8 1.7e-18 67.7 1.8 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFX00990.1 - 2e-18 66.3 0.0 3.8e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) APG12 PF04110.13 EFX00990.1 - 9.9e-09 35.5 0.0 3.7e-08 33.7 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like autophagy protein Apg12 Cation_ATPase_N PF00690.26 EFX00990.1 - 7e-07 28.9 0.2 3.6e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFX00990.1 - 0.00025 20.9 0.2 0.00046 20.0 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LptF_LptG PF03739.14 EFX00990.1 - 0.51 9.1 4.4 0.36 9.6 1.9 1.9 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG Transthyretin PF00576.21 EFX00991.1 - 6.8e-35 120.1 0.0 1.6e-34 118.9 0.0 1.6 1 1 0 1 1 1 1 HIUase/Transthyretin family POT1PC PF16686.5 EFX00992.1 - 9.4e-42 142.5 0.0 2.1e-41 141.4 0.0 1.6 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EFX00992.1 - 7.7e-15 55.0 0.0 2e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 REPA_OB_2 PF16900.5 EFX00992.1 - 1.6e-06 27.9 0.0 4.6e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Replication protein A OB domain Rtf2 PF04641.12 EFX00992.1 - 0.38 10.1 9.2 0.12 11.7 4.3 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger Cation_efflux PF01545.21 EFX00993.1 - 1.1e-07 31.9 0.3 1.9e-07 31.0 0.3 1.4 1 1 0 1 1 1 1 Cation efflux family MNHE PF01899.16 EFX00993.1 - 0.19 11.5 0.1 0.19 11.5 0.1 1.8 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit DUF4131 PF13567.6 EFX00993.1 - 6.8 6.3 6.5 18 5.0 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Tubulin PF00091.25 EFX00994.1 - 1.4e-69 234.3 0.0 3.1e-69 233.1 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFX00994.1 - 4.5e-43 146.4 0.1 7.1e-43 145.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFX00994.1 - 1.3e-05 25.5 0.0 2.8e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EFX00994.1 - 0.00047 19.5 0.0 0.01 15.0 0.0 2.1 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EFX00994.1 - 0.0019 17.9 0.0 0.0036 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain zinc_ribbon_9 PF14369.6 EFX00995.1 - 0.17 12.2 4.1 0.23 11.7 0.3 2.5 2 1 0 2 2 2 0 zinc-ribbon DUF1660 PF07874.11 EFX00995.1 - 0.58 10.7 4.8 2.5 8.7 0.3 2.1 1 1 1 2 2 2 0 Prophage protein (DUF1660) ADH_N PF08240.12 EFX00996.1 - 1.8e-26 92.1 0.6 4.3e-26 90.9 0.6 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX00996.1 - 2.2e-19 69.7 0.2 4.2e-19 68.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EFX00996.1 - 0.015 14.9 0.1 0.027 14.1 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glu_dehyd_C PF16912.5 EFX00996.1 - 0.018 14.5 0.2 0.28 10.6 0.2 2.2 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EFX00996.1 - 0.05 12.9 1.9 0.083 12.2 1.5 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IGFBP PF00219.18 EFX00996.1 - 0.096 13.4 0.4 0.096 13.4 0.4 1.8 2 0 0 2 2 2 0 Insulin-like growth factor binding protein Sacchrp_dh_NADP PF03435.18 EFX00996.1 - 0.099 12.9 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pep_deformylase PF01327.21 EFX00996.1 - 0.2 11.2 0.0 1 9.0 0.0 1.9 2 0 0 2 2 2 0 Polypeptide deformylase Ribosomal_S21e PF01249.18 EFX00997.1 - 4.4e-39 132.5 0.1 4.9e-39 132.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e DUF572 PF04502.13 EFX00998.1 - 4.8e-45 154.6 0.0 5.1e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) FAM199X PF15814.5 EFX00998.1 - 0.87 8.6 3.5 1.3 8.0 3.5 1.2 1 0 0 1 1 1 0 Protein family FAM199X Pkinase PF00069.25 EFX00999.1 - 2.8e-71 240.0 1.1 4.4e-71 239.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX00999.1 - 2.3e-45 154.9 1.1 2.3e-45 154.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 EFX00999.1 - 3.8e-19 68.8 0.0 1.4e-18 67.0 0.0 2.1 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EFX00999.1 - 1.4e-07 31.1 0.0 1.4e-07 31.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFX00999.1 - 0.01 15.2 0.1 0.11 11.9 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX00999.1 - 0.21 11.5 0.0 0.21 11.5 0.0 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family FTA2 PF13095.6 EFX00999.1 - 0.26 10.9 0.0 0.26 10.9 0.0 2.5 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EFX00999.1 - 0.59 8.8 23.1 0.018 13.8 13.9 2.8 2 1 0 2 2 2 0 Fungal protein kinase Sec7 PF01369.20 EFX01000.1 - 2.7e-32 111.9 0.2 4.3e-32 111.3 0.2 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EFX01000.1 - 1.7e-07 31.7 0.0 4.6e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EFX01000.1 - 2.4e-05 24.7 0.0 5.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Pkinase PF00069.25 EFX01001.1 - 3.4e-66 223.3 0.0 4.1e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01001.1 - 5.6e-31 107.8 0.0 7.6e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFX01001.1 - 0.002 17.2 0.0 0.0029 16.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFX01001.1 - 0.0074 15.6 0.0 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFX01001.1 - 0.029 13.2 0.0 0.042 12.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EFX01001.1 - 0.054 13.1 0.0 0.38 10.4 0.0 2.0 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF2408 PF10303.9 EFX01002.1 - 2e-35 122.3 0.6 4.2e-27 95.4 0.0 4.0 3 2 0 3 3 3 2 Protein of unknown function (DUF2408) CARD PF00619.21 EFX01002.1 - 0.048 13.7 0.0 0.2 11.7 0.0 2.0 2 0 0 2 2 2 0 Caspase recruitment domain Dna2 PF08696.11 EFX01003.1 - 5.5e-68 228.8 0.0 8.5e-68 228.2 0.0 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EFX01003.1 - 5.3e-52 176.4 0.0 8.5e-52 175.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFX01003.1 - 5.8e-35 121.3 0.1 4.8e-17 62.6 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EFX01003.1 - 3.4e-14 53.0 0.0 9.4e-14 51.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX01003.1 - 3.4e-12 46.9 0.0 1.2e-11 45.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain Cas_Cas4 PF01930.17 EFX01003.1 - 1.1e-08 35.3 0.0 7.7e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 EFX01003.1 - 4.5e-06 26.6 0.1 0.34 10.6 0.1 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PDDEXK_1 PF12705.7 EFX01003.1 - 3.5e-05 23.8 0.1 8.2e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily UvrD-helicase PF00580.21 EFX01003.1 - 0.00048 19.7 0.1 0.00082 19.0 0.1 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 EFX01003.1 - 0.00059 19.5 0.2 0.0011 18.6 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Helicase_RecD PF05127.14 EFX01003.1 - 0.00063 19.6 0.0 0.0029 17.5 0.0 2.1 1 1 0 1 1 1 1 Helicase AAA_16 PF13191.6 EFX01003.1 - 0.0021 18.4 0.0 0.012 16.0 0.0 2.3 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 EFX01003.1 - 0.0036 17.4 0.2 0.0084 16.2 0.2 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 EFX01003.1 - 0.0073 15.9 0.0 0.16 11.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EFX01003.1 - 0.032 14.2 0.0 0.09 12.8 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PIF1 PF05970.14 EFX01003.1 - 0.038 13.2 0.0 0.49 9.5 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase MeaB PF03308.16 EFX01003.1 - 0.039 12.9 0.0 0.079 11.9 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 EFX01003.1 - 0.06 13.1 0.0 0.17 11.6 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF87 PF01935.17 EFX01003.1 - 0.064 13.3 0.2 0.15 12.1 0.1 1.6 2 0 0 2 2 1 0 Helicase HerA, central domain AAA_33 PF13671.6 EFX01003.1 - 0.079 13.1 0.3 1.5 9.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EFX01003.1 - 0.11 12.4 0.5 0.38 10.6 0.1 2.0 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 EFX01003.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PEPCK_ATP PF01293.20 EFX01003.1 - 0.16 10.6 0.0 0.27 9.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase DUF3275 PF11679.8 EFX01003.1 - 0.17 11.8 0.8 0.68 9.9 0.8 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) AAA PF00004.29 EFX01003.1 - 0.19 12.2 0.1 0.49 10.8 0.1 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) adh_short_C2 PF13561.6 EFX01004.1 - 6e-46 156.9 0.1 7.9e-46 156.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01004.1 - 5.8e-41 140.1 1.1 7.3e-41 139.8 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01004.1 - 3.1e-07 30.5 0.6 5.1e-07 29.8 0.6 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX01004.1 - 2e-06 27.5 0.4 4.8e-06 26.2 0.4 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Orthopox_C10L PF07020.11 EFX01004.1 - 0.0022 18.7 0.8 0.11 13.2 0.1 2.4 2 0 0 2 2 2 1 Orthopoxvirus C10L protein RmlD_sub_bind PF04321.17 EFX01004.1 - 0.11 11.5 0.1 0.18 10.9 0.1 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Methyltransf_16 PF10294.9 EFX01005.1 - 6.5e-21 74.8 0.0 9.6e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EFX01005.1 - 0.0009 19.9 0.1 0.002 18.8 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFX01005.1 - 0.0026 17.2 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFX01005.1 - 0.0054 16.3 0.0 0.0098 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EFX01005.1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFX01005.1 - 0.017 14.9 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFX01005.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01005.1 - 0.05 14.4 0.1 0.11 13.3 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EFX01005.1 - 0.23 11.2 0.0 0.37 10.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein PNP_UDP_1 PF01048.20 EFX01006.1 - 1e-38 132.9 1.2 1.4e-38 132.5 1.2 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Flavin_Reduct PF01613.18 EFX01007.1 - 1.2e-25 90.4 0.0 1.6e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain PAS_5 PF07310.13 EFX01007.1 - 0.034 13.9 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 PAS domain Ferric_reduct PF01794.19 EFX01008.1 - 1e-19 70.8 9.0 1e-19 70.8 9.0 2.5 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFX01008.1 - 6e-17 62.2 0.0 1.4e-16 61.0 0.0 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFX01008.1 - 4.7e-13 49.2 0.0 1.5e-12 47.6 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EFX01008.1 - 0.00038 21.1 0.0 0.29 11.8 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4173 PF13777.6 EFX01008.1 - 0.018 14.5 8.8 0.65 9.4 2.8 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4173) DUF1951 PF09188.10 EFX01008.1 - 0.061 13.3 0.0 0.57 10.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1951) Msap1 PF17077.5 EFX01008.1 - 0.07 12.3 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 TctB PF07331.11 EFX01008.1 - 0.88 9.8 11.6 0.12 12.7 2.7 2.7 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF2975 PF11188.8 EFX01008.1 - 5.1 7.0 7.9 1.5 8.7 0.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) UreD PF01774.17 EFX01009.1 - 8.8e-73 244.7 0.3 1.1e-72 244.5 0.3 1.1 1 0 0 1 1 1 1 UreD urease accessory protein Pantoate_transf PF02548.15 EFX01010.1 - 1.1e-105 352.7 1.0 1.3e-105 352.4 1.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EFX01010.1 - 7.1e-07 28.9 4.3 1.5e-06 27.9 4.3 1.5 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 EFX01010.1 - 0.061 12.3 0.0 0.087 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) Ifi-6-16 PF06140.13 EFX01011.1 - 3e-15 55.9 24.8 3e-15 55.9 24.8 3.6 1 1 2 3 3 3 1 Interferon-induced 6-16 family zf-AN1 PF01428.16 EFX01012.1 - 2.6e-13 49.9 5.2 2.6e-13 49.9 5.2 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EFX01012.1 - 0.17 12.2 6.9 0.073 13.4 4.6 1.6 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain IBR PF01485.21 EFX01012.1 - 2.6 8.3 11.2 1.3 9.3 6.4 2.1 1 1 0 2 2 2 0 IBR domain, a half RING-finger domain CK_II_beta PF01214.18 EFX01013.1 - 1.1e-76 256.7 0.1 1.4e-76 256.4 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Dynamin_M PF01031.20 EFX01014.1 - 6.4e-100 334.1 0.0 1.1e-99 333.3 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EFX01014.1 - 1.7e-56 190.9 0.0 3e-56 190.1 0.0 1.4 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EFX01014.1 - 2.7e-29 101.1 7.8 4e-29 100.6 4.1 2.4 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFX01014.1 - 2.6e-05 24.3 0.3 0.00059 19.9 0.3 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EFX01014.1 - 0.17 11.6 1.4 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain Macoilin PF09726.9 EFX01015.1 - 1.2e-05 24.1 10.5 1.2e-05 24.1 10.5 5.2 1 1 4 5 5 5 1 Macoilin family BRAP2 PF07576.12 EFX01016.1 - 1.5e-28 98.9 0.0 3.2e-28 97.9 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EFX01016.1 - 6.9e-17 61.5 6.6 1.7e-16 60.3 6.6 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Acyltransferase PF01553.21 EFX01016.1 - 5.7e-09 35.7 0.0 0.00095 18.8 0.0 2.9 3 0 0 3 3 3 2 Acyltransferase zf-RING_2 PF13639.6 EFX01016.1 - 1.1e-07 32.1 9.3 1.1e-07 32.1 9.3 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFX01016.1 - 2.5e-06 27.2 10.0 5.2e-06 26.2 10.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX01016.1 - 0.00036 20.4 7.1 0.00088 19.2 7.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFX01016.1 - 0.00044 20.1 8.4 0.00093 19.0 8.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFX01016.1 - 0.00048 19.8 4.9 0.00048 19.8 4.9 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFX01016.1 - 0.00052 20.0 5.8 0.0019 18.2 5.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFX01016.1 - 0.00075 19.7 6.6 0.0019 18.5 6.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFX01016.1 - 0.005 16.7 6.5 0.005 16.7 6.5 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX01016.1 - 0.011 15.5 9.7 0.33 10.9 9.7 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFX01016.1 - 0.047 13.7 6.1 0.13 12.3 6.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EFX01016.1 - 0.13 12.2 6.4 0.038 13.9 2.7 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein MttA_Hcf106 PF02416.16 EFX01016.1 - 0.18 11.1 0.0 0.5 9.7 0.0 1.7 1 0 0 1 1 1 0 mttA/Hcf106 family Rit1_C PF17184.4 EFX01017.1 - 5.1e-95 318.0 0.0 6.7e-95 317.6 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EFX01017.1 - 8.9e-35 119.3 0.0 1.6e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain RNA_pol_Rpb2_4 PF04566.13 EFX01017.1 - 0.28 11.5 1.7 0.66 10.3 0.0 2.4 3 0 0 3 3 3 0 RNA polymerase Rpb2, domain 4 RFX_DNA_binding PF02257.15 EFX01018.1 - 4.4e-27 94.5 0.0 8.6e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain Cdc6_C PF09079.11 EFX01018.1 - 0.15 12.0 0.0 0.57 10.2 0.0 1.9 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain SIR2 PF02146.17 EFX01019.1 - 1.2e-57 194.7 0.0 2e-57 194.0 0.0 1.4 1 0 0 1 1 1 1 Sir2 family SHD1 PF03983.12 EFX01019.1 - 2.1e-33 113.9 0.1 3.5e-33 113.2 0.1 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 EFX01019.1 - 1.9e-31 107.4 5.2 7.8e-11 41.4 0.0 4.3 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EFX01019.1 - 2e-31 107.6 10.8 6e-10 38.8 0.5 3.9 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EFX01019.1 - 8.1e-20 70.3 0.3 1.7e-06 27.6 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain SAM_4 PF18017.1 EFX01019.1 - 0.00026 20.9 0.0 0.00052 19.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_3 PF08239.11 EFX01019.1 - 0.002 18.4 0.5 0.002 18.4 0.5 2.6 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 EFX01019.1 - 0.0042 17.1 0.0 0.064 13.3 0.0 2.5 2 0 0 2 2 2 1 SH3 domain DUF1720 PF08226.11 EFX01019.1 - 0.0042 17.5 51.4 0.0042 17.5 51.4 5.9 2 1 3 5 5 4 2 Domain of unknown function (DUF1720) DUF592 PF04574.13 EFX01019.1 - 0.0075 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EFX01019.1 - 0.013 15.2 0.1 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain PEX11 PF05648.14 EFX01020.1 - 4e-14 52.6 0.1 1.6e-09 37.5 0.0 3.5 3 1 0 3 3 3 3 Peroxisomal biogenesis factor 11 (PEX11) Dor1 PF04124.12 EFX01021.1 - 5.2e-45 153.6 0.0 3.9e-41 140.9 0.0 2.3 1 1 1 2 2 2 2 Dor1-like family RRM_1 PF00076.22 EFX01022.1 - 6.4e-34 115.6 0.2 1.1e-15 57.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFX01022.1 - 1.3e-11 44.5 0.1 0.00022 21.3 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EFX01022.1 - 0.00022 21.2 0.0 0.3 11.1 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif DUF2722 PF10846.8 EFX01022.1 - 0.0018 17.3 7.2 0.003 16.6 7.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DDHD PF02862.17 EFX01022.1 - 0.036 14.2 0.1 0.052 13.7 0.1 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EFX01022.1 - 0.045 12.5 1.6 0.062 12.1 1.6 1.1 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 EFX01022.1 - 0.96 8.4 9.0 1.3 7.9 9.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4407 PF14362.6 EFX01022.1 - 1.4 8.2 6.4 2.1 7.6 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 EFX01022.1 - 1.6 8.7 4.8 1.1 9.3 3.2 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3408 PF11888.8 EFX01022.1 - 2.3 8.4 6.3 6 7.0 6.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Band_3_cyto PF07565.13 EFX01022.1 - 2.6 7.8 5.1 3.9 7.2 4.6 1.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF1631 PF07793.11 EFX01022.1 - 3.5 5.9 16.6 4.9 5.5 16.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) PAS PF00989.25 EFX01023.1 - 0.00081 19.4 0.0 0.0022 18.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 EFX01023.1 - 0.0091 16.1 8.6 0.0091 16.1 8.6 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YL1 PF05764.13 EFX01023.1 - 0.78 9.8 12.1 0.072 13.2 0.9 2.1 2 0 0 2 2 2 0 YL1 nuclear protein CDC45 PF02724.14 EFX01023.1 - 7.3 4.7 7.8 1.4 7.1 3.3 1.8 2 0 0 2 2 2 0 CDC45-like protein DUF3015 PF11220.8 EFX01024.1 - 0.069 13.0 0.2 0.16 11.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) DUF3783 PF12646.7 EFX01024.1 - 0.12 12.4 1.2 0.36 10.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3783) Cob_adeno_trans PF01923.18 EFX01024.1 - 0.16 12.1 4.5 0.39 10.8 1.6 2.7 2 1 0 2 2 2 0 Cobalamin adenosyltransferase EF-hand_1 PF00036.32 EFX01025.1 - 1.4e-41 137.0 12.9 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFX01025.1 - 6.7e-36 122.6 5.3 8.1e-19 67.9 1.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFX01025.1 - 3.2e-35 119.7 11.1 1.3e-15 56.9 0.5 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EFX01025.1 - 1.6e-30 102.4 9.1 1.9e-09 36.7 0.2 4.4 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFX01025.1 - 6.4e-26 88.7 10.6 2.6e-06 26.7 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EFX01025.1 - 9e-17 61.2 0.3 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFX01025.1 - 4.9e-09 36.5 0.2 0.0014 18.9 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFX01025.1 - 7.3e-09 35.5 1.6 0.0019 18.1 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 EFX01025.1 - 1.9e-06 27.8 0.1 0.0077 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EFX01025.1 - 1e-05 25.5 1.6 4.4e-05 23.5 0.2 2.4 2 2 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EFX01025.1 - 2.6e-05 25.0 0.2 0.00063 20.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EFX01025.1 - 5.1e-05 23.3 0.4 0.31 11.0 0.1 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EFX01025.1 - 0.00046 20.1 1.9 0.44 10.5 0.0 3.6 1 1 3 4 4 4 1 Caleosin related protein DUF3349 PF11829.8 EFX01025.1 - 0.0011 19.7 0.5 3.7 8.4 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Dockerin_1 PF00404.18 EFX01025.1 - 0.0026 17.9 5.9 0.25 11.6 0.4 3.0 1 1 1 2 2 2 2 Dockerin type I domain RNA_pol_Rpb4 PF03874.16 EFX01025.1 - 0.0032 17.8 1.0 3.1 8.1 0.1 2.7 2 1 1 3 3 3 2 RNA polymerase Rpb4 DUF5580 PF17743.1 EFX01025.1 - 0.0047 15.5 0.0 0.0048 15.5 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EFX01025.1 - 0.014 15.3 0.9 0.47 10.3 0.2 2.2 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_14 PF17959.1 EFX01025.1 - 0.016 15.6 0.5 6.7 7.1 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 EFX01025.1 - 0.019 15.2 0.0 0.18 12.1 0.0 2.6 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein DUF4497 PF14924.6 EFX01025.1 - 0.068 13.7 0.0 16 6.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) MotA_activ PF09114.10 EFX01025.1 - 0.074 13.2 0.3 1.4 9.1 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain RuvA_C PF07499.13 EFX01025.1 - 0.11 13.0 0.1 16 6.0 0.1 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain RloB PF13707.6 EFX01025.1 - 0.14 12.3 1.1 0.63 10.2 0.2 2.0 1 1 1 2 2 2 0 RloB-like protein DUF5132 PF17195.4 EFX01025.1 - 0.18 11.9 0.8 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) zf-C2H2_4 PF13894.6 EFX01026.1 - 0.0043 17.8 27.0 0.54 11.2 0.3 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger DUF3362 PF11842.8 EFX01026.1 - 0.011 16.0 3.1 0.031 14.6 3.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) Eapp_C PF10238.9 EFX01026.1 - 0.53 10.4 3.4 0.41 10.7 0.4 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein Zn_clus PF00172.18 EFX01026.1 - 2.5 8.3 11.4 0.18 11.9 5.4 2.3 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3 PF00933.21 EFX01027.1 - 3.9e-42 144.8 0.0 6.3e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFX01027.1 - 8.8e-42 143.4 0.0 1.7e-41 142.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFX01027.1 - 2.1e-22 79.0 0.1 3.8e-22 78.2 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Flavoprotein PF02441.19 EFX01028.1 - 6.2e-25 87.8 0.1 9.7e-25 87.2 0.1 1.3 1 0 0 1 1 1 1 Flavoprotein Uds1 PF15456.6 EFX01029.1 - 2.2e-31 108.7 8.0 2.2e-31 108.7 8.0 2.2 2 0 0 2 2 2 1 Up-regulated During Septation Stathmin PF00836.19 EFX01029.1 - 0.059 13.3 1.1 0.22 11.5 1.1 1.9 1 0 0 1 1 1 0 Stathmin family Wbp11 PF09429.10 EFX01029.1 - 0.64 10.5 3.2 0.65 10.4 0.2 2.6 2 0 0 2 2 2 0 WW domain binding protein 11 APG6_N PF17675.1 EFX01029.1 - 6.4 7.3 9.0 39 4.8 3.3 3.1 2 1 1 3 3 3 0 Apg6 coiled-coil region DnaJ_C PF01556.18 EFX01030.1 - 2.3e-37 128.4 1.2 3e-37 128.0 1.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFX01030.1 - 8.2e-26 89.9 3.6 1.4e-25 89.2 3.6 1.4 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 EFX01031.1 - 1.6e-22 79.4 17.7 8.4e-07 29.6 0.3 7.2 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01031.1 - 8.6e-09 35.6 0.5 0.026 14.8 0.0 5.3 2 2 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFX01031.1 - 0.018 15.0 0.1 44 4.2 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_3 PF15911.5 EFX01031.1 - 0.13 12.3 0.0 2.2 8.4 0.0 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat Fungal_trans PF04082.18 EFX01032.1 - 0.021 13.9 0.0 0.036 13.1 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain VCPO_N PF17897.1 EFX01032.1 - 1.4 8.7 5.1 2.4 7.9 5.1 1.4 1 0 0 1 1 1 0 Vanadium chloroperoxidase N-terminal domain Abhydrolase_1 PF00561.20 EFX01033.1 - 1.3e-18 67.6 0.1 1e-17 64.7 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX01033.1 - 5.3e-16 59.9 0.1 6.6e-16 59.6 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX01033.1 - 2.1e-06 27.2 0.2 3.4e-06 26.5 0.2 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EFX01033.1 - 2.9e-05 24.3 0.1 4.1e-05 23.8 0.1 1.3 1 1 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EFX01033.1 - 0.00021 21.0 0.0 0.00025 20.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase DUF1057 PF06342.12 EFX01033.1 - 0.0047 16.0 0.0 0.0067 15.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) UPF0227 PF05728.12 EFX01033.1 - 0.019 14.9 0.1 0.03 14.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.7 EFX01033.1 - 0.02 14.6 0.0 0.042 13.6 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EFX01033.1 - 0.024 14.4 0.4 2.5 7.8 0.0 2.6 2 1 1 3 3 3 0 PGAP1-like protein Palm_thioest PF02089.15 EFX01033.1 - 0.078 12.8 0.0 0.11 12.3 0.0 1.3 1 1 0 1 1 1 0 Palmitoyl protein thioesterase LIDHydrolase PF10230.9 EFX01033.1 - 0.082 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF676 PF05057.14 EFX01033.1 - 0.098 12.2 0.1 0.19 11.2 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 EFX01033.1 - 0.19 11.5 0.8 13 5.5 0.1 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase zf-C3HC4_3 PF13920.6 EFX01034.1 - 6.4e-09 35.5 8.8 6.4e-09 35.5 8.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFX01034.1 - 5e-08 33.2 11.1 9e-08 32.3 11.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFX01034.1 - 1.6e-07 31.1 10.7 2.9e-07 30.2 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX01034.1 - 2.5e-07 30.4 11.6 4.6e-07 29.6 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX01034.1 - 2e-06 27.6 9.3 3.7e-06 26.7 9.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Helicase_C PF00271.31 EFX01034.1 - 8.3e-06 26.1 0.0 2.3e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-rbx1 PF12678.7 EFX01034.1 - 5.3e-05 23.4 9.6 0.00014 22.1 9.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFX01034.1 - 0.00035 20.5 11.2 0.00065 19.6 11.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFX01034.1 - 0.0013 18.7 7.5 0.0031 17.5 7.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFX01034.1 - 0.081 13.1 9.8 0.17 12.1 9.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EFX01034.1 - 0.21 11.7 6.8 0.43 10.7 6.6 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFX01034.1 - 0.27 11.1 8.4 0.13 12.1 5.4 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FAM219A PF15260.6 EFX01034.1 - 0.57 10.6 4.1 2.6 8.4 0.0 3.0 3 0 0 3 3 3 0 Protein family FAM219A Nsp1_C PF05064.13 EFX01034.1 - 0.79 9.6 12.1 0.29 10.9 1.9 3.4 3 0 0 3 3 3 0 Nsp1-like C-terminal region DZR PF12773.7 EFX01034.1 - 2.6 8.1 7.4 9.7 6.3 7.4 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_10 PF16685.5 EFX01034.1 - 2.7 8.2 8.0 2.6 8.2 6.3 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 Spore_II_R PF09551.10 EFX01034.1 - 4.5 7.8 5.9 2.7 8.5 2.9 2.3 2 0 0 2 2 1 0 Stage II sporulation protein R (spore_II_R) Zn_ribbon_17 PF17120.5 EFX01034.1 - 5.2 6.8 11.3 12 5.6 11.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-P11 PF03854.14 EFX01034.1 - 6.4 6.5 7.1 23 4.8 7.2 1.9 1 1 0 1 1 1 0 P-11 zinc finger PMSR PF01625.21 EFX01035.1 - 9.1e-57 191.5 0.3 1.6e-56 190.8 0.3 1.4 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Rad60-SLD_2 PF13881.6 EFX01036.1 - 9.7e-05 22.4 0.0 0.00054 20.0 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFX01036.1 - 0.00016 21.4 0.0 0.00031 20.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EFX01036.1 - 0.00077 20.0 0.0 0.0018 18.8 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain XLF PF09302.11 EFX01037.1 - 4.1e-49 167.2 0.0 1.1e-48 165.7 0.0 1.8 2 0 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Fungal_trans PF04082.18 EFX01037.1 - 2.1e-16 59.8 0.0 3.4e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01037.1 - 1.8e-08 34.3 10.0 2.9e-08 33.7 10.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-I PF07778.11 EFX01038.1 - 8.4e-36 123.8 0.0 1.9e-35 122.6 0.0 1.4 1 1 0 1 1 1 1 Mis6 GHMP_kinases_N PF00288.26 EFX01038.1 - 0.081 13.2 2.7 35 4.7 0.1 4.0 3 0 0 3 3 3 0 GHMP kinases N terminal domain TFIIA PF03153.13 EFX01039.1 - 0.7 9.8 9.3 0.85 9.5 9.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EFX01039.1 - 0.97 9.0 9.6 1.3 8.6 9.6 1.2 1 0 0 1 1 1 0 Spt20 family EBP50_C PF09007.11 EFX01039.1 - 7.8 7.5 9.8 4.8 8.2 4.1 2.1 2 0 0 2 2 2 0 EBP50, C-terminal Pex2_Pex12 PF04757.14 EFX01040.1 - 1.6e-36 126.0 0.0 2.5e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-primase PF09329.11 EFX01040.1 - 2.2e-18 65.8 1.2 3.8e-18 65.0 1.2 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 EFX01040.1 - 0.019 14.9 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain zf-C3HC4_4 PF15227.6 EFX01040.1 - 0.13 12.4 3.6 0.24 11.6 3.6 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EFX01040.1 - 0.36 10.9 1.5 0.78 9.8 1.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF3405 PF11885.8 EFX01041.1 - 2.3e-210 699.6 0.0 2.8e-210 699.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Methyltransf_23 PF13489.6 EFX01042.1 - 9.4e-17 61.3 0.0 1.3e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01042.1 - 8.9e-09 35.9 0.0 2.5e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX01042.1 - 2.2e-08 34.7 0.0 8.3e-08 32.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01042.1 - 1.4e-06 29.0 0.0 9.2e-06 26.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01042.1 - 0.0046 16.8 0.0 0.35 10.7 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 EFX01042.1 - 0.013 14.8 0.0 0.053 12.8 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_16 PF10294.9 EFX01042.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 EFX01042.1 - 0.02 14.3 0.0 1.7 7.9 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFX01042.1 - 0.087 12.3 0.0 0.19 11.2 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase UAA PF08449.11 EFX01043.1 - 6.1e-105 350.7 1.4 7.6e-105 350.4 1.4 1.0 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EFX01043.1 - 1e-05 24.9 1.4 1.8e-05 24.0 1.4 1.6 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EFX01043.1 - 0.0014 18.8 29.7 0.22 11.7 8.5 4.0 2 2 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 EFX01043.1 - 0.0029 16.9 0.2 0.0029 16.9 0.2 1.9 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport Vps39_2 PF10367.9 EFX01044.1 - 1.3e-07 32.0 0.0 3.2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EFX01044.1 - 0.0022 18.3 0.0 0.012 15.9 0.0 2.2 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.6 EFX01044.1 - 0.16 12.1 0.1 1.7 8.8 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 EFX01045.1 - 1.4e-07 31.2 0.0 3.4e-07 30.0 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFX01045.1 - 5.7e-05 22.7 0.0 7.7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFX01045.1 - 0.029 14.4 1.8 0.031 14.4 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 Ribosomal_60s PF00428.19 EFX01045.1 - 0.036 14.7 5.1 0.087 13.4 5.1 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Calcipressin PF04847.12 EFX01045.1 - 0.037 13.8 0.3 0.073 12.8 0.0 1.8 2 0 0 2 2 2 0 Calcipressin Abhydrolase_1 PF00561.20 EFX01046.1 - 9.2e-24 84.5 0.0 4.9e-18 65.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX01046.1 - 2e-15 58.0 0.9 2.6e-15 57.6 0.9 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX01046.1 - 2.2e-11 43.5 0.0 4.7e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EFX01046.1 - 4.6e-07 29.8 0.0 0.019 14.7 0.0 2.2 1 1 1 2 2 2 2 PGAP1-like protein Thioesterase PF00975.20 EFX01046.1 - 6.6e-07 29.7 0.0 9.8e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EFX01046.1 - 0.0027 17.4 0.0 0.0042 16.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase DUF915 PF06028.11 EFX01046.1 - 0.0074 15.7 0.0 2.6 7.3 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 EFX01046.1 - 0.0085 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) UPF0227 PF05728.12 EFX01046.1 - 0.0086 16.0 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Ndr PF03096.14 EFX01046.1 - 0.011 14.5 0.0 0.02 13.6 0.0 1.4 1 0 0 1 1 1 0 Ndr family Chlorophyllase2 PF12740.7 EFX01046.1 - 0.027 13.4 0.0 0.043 12.7 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme DLH PF01738.18 EFX01046.1 - 0.041 13.4 0.0 1.2 8.7 0.0 2.2 1 1 0 1 1 1 0 Dienelactone hydrolase family Chlorophyllase PF07224.11 EFX01046.1 - 0.061 12.3 0.0 0.095 11.7 0.0 1.4 1 1 0 1 1 1 0 Chlorophyllase DUF676 PF05057.14 EFX01046.1 - 0.068 12.7 0.0 0.094 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) IMS_HHH PF11798.8 EFX01046.1 - 0.08 13.3 0.0 0.26 11.7 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif DUF900 PF05990.12 EFX01046.1 - 0.089 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Palm_thioest PF02089.15 EFX01046.1 - 0.19 11.5 0.0 0.25 11.1 0.0 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase LCAT PF02450.15 EFX01046.1 - 0.24 10.5 0.0 0.35 10.0 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Asp_protease PF09668.10 EFX01048.1 - 1.5e-59 199.2 0.3 2.1e-59 198.8 0.3 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EFX01048.1 - 6e-25 87.6 1.3 1.2e-24 86.6 0.1 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EFX01048.1 - 8.2e-12 45.6 2.2 1.3e-11 44.9 0.1 2.3 2 1 2 4 4 4 1 Aspartyl protease UBA PF00627.31 EFX01048.1 - 3.5e-11 42.8 0.1 8.2e-11 41.6 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain RVP PF00077.20 EFX01048.1 - 0.00029 21.1 0.0 0.00085 19.6 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 EFX01048.1 - 0.00079 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.6 EFX01048.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain Ist1 PF03398.14 EFX01048.1 - 0.15 12.0 0.5 0.24 11.3 0.5 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway RuvA_C PF07499.13 EFX01048.1 - 0.17 12.4 1.2 0.73 10.3 0.1 2.5 2 0 0 2 2 2 0 RuvA, C-terminal domain UCH PF00443.29 EFX01049.1 - 3.5e-26 92.2 0.0 4.8e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFX01049.1 - 7.9e-12 45.3 0.3 1.4e-11 44.5 0.3 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EFX01049.1 - 0.01 15.5 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PcfK PF14058.6 EFX01050.1 - 0.59 10.4 12.5 0.029 14.6 3.0 2.4 2 0 0 2 2 2 0 PcfK-like protein PNISR PF15996.5 EFX01050.1 - 5.4 7.2 34.6 2.3 8.5 17.9 2.2 1 1 1 2 2 2 0 Arginine/serine-rich protein PNISR DUF1764 PF08576.10 EFX01050.1 - 10 7.1 19.2 6.8 7.7 8.6 2.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF3384 PF11864.8 EFX01051.1 - 1e-127 427.0 0.0 1.3e-126 423.3 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EFX01051.1 - 1e-52 178.4 0.0 1.9e-52 177.5 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EFX01051.1 - 1.5e-36 126.2 0.0 4.3e-34 118.2 0.0 3.1 3 0 0 3 3 3 2 Tuberin UNC45-central PF11701.8 EFX01051.1 - 0.1 12.6 0.1 4.3 7.3 0.0 3.2 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central Med13_C PF06333.12 EFX01052.1 - 1.5e-76 257.8 0.1 1.5e-76 257.8 0.1 2.9 4 0 0 4 4 4 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EFX01052.1 - 2.3e-24 86.4 0.0 7e-24 84.8 0.0 1.8 1 1 0 1 1 1 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EFX01052.1 - 1.3e-12 48.0 8.9 6.7e-07 29.4 0.0 3.3 3 1 1 4 4 4 2 MID domain of medPIWI NOA36 PF06524.12 EFX01052.1 - 0.16 11.3 0.5 0.26 10.6 0.5 1.2 1 0 0 1 1 1 0 NOA36 protein Hydrolase_4 PF12146.8 EFX01053.1 - 5.1e-46 156.9 0.0 6.1e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFX01053.1 - 2.1e-14 54.7 5.1 2.1e-14 54.7 5.1 1.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX01053.1 - 8.3e-09 35.5 1.2 1e-08 35.1 0.3 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF900 PF05990.12 EFX01053.1 - 0.057 12.9 0.0 9.3 5.7 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EFX01053.1 - 0.064 13.0 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Peptidase_S9 PF00326.21 EFX01053.1 - 0.11 11.9 0.9 3.9 6.9 0.4 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Porin_3 PF01459.22 EFX01055.1 - 1.1e-80 271.0 0.2 1.3e-80 270.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin MFS_1 PF07690.16 EFX01056.1 - 1.9e-24 86.3 32.8 1.9e-24 86.3 32.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3796 PF12676.7 EFX01056.1 - 0.0095 16.4 0.7 0.025 15.0 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3796) FAD_binding_4 PF01565.23 EFX01057.1 - 3.2e-12 46.4 0.3 6.6e-12 45.3 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Glyco_transf_15 PF01793.16 EFX01058.1 - 5.3e-114 380.8 3.1 6.4e-114 380.6 3.1 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Piwi PF02171.17 EFX01059.1 - 1.3e-70 238.1 0.0 2.2e-70 237.3 0.0 1.4 1 0 0 1 1 1 1 Piwi domain ArgoL1 PF08699.10 EFX01059.1 - 1.1e-15 57.0 0.1 3.6e-15 55.4 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EFX01059.1 - 3e-11 43.5 0.0 6.3e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EFX01059.1 - 3.3e-08 33.4 0.0 5.5e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 EFX01059.1 - 0.012 16.2 0.0 0.024 15.2 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of argonaute DUF5594 PF18057.1 EFX01059.1 - 0.055 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5594) HMG_box PF00505.19 EFX01060.1 - 4.9e-09 36.5 3.1 8.6e-09 35.7 3.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFX01060.1 - 2.9e-06 27.8 3.1 6.2e-06 26.7 3.1 1.6 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EFX01060.1 - 0.014 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box ANAPC1 PF12859.7 EFX01060.1 - 4.8 7.8 6.6 3.9 8.1 2.3 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 Phosphoesterase PF04185.14 EFX01061.1 - 2.1e-69 234.4 3.1 2.9e-69 234.0 3.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family zf-Nse PF11789.8 EFX01062.1 - 4e-19 68.2 0.9 5.8e-19 67.7 0.2 1.6 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EFX01062.1 - 3.4e-06 27.2 0.0 7.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 EFX01062.1 - 0.0016 18.2 0.3 0.0016 18.2 0.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX01062.1 - 0.004 17.1 0.2 0.009 16.0 0.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.20 EFX01062.1 - 0.015 15.0 0.6 0.028 14.2 0.6 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Rrn6 PF10214.9 EFX01062.1 - 0.19 10.2 4.4 0.26 9.7 4.4 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor PGAP1 PF07819.13 EFX01062.1 - 0.2 11.4 0.1 0.34 10.6 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2203 PF09969.9 EFX01062.1 - 0.31 11.8 0.2 0.31 11.8 0.2 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Ecm33 PF12454.8 EFX01063.1 - 2.3e-08 34.1 1.5 9e-08 32.1 1.5 2.2 1 0 0 1 1 1 1 GPI-anchored cell wall organization protein Recep_L_domain PF01030.24 EFX01063.1 - 2.2e-07 31.0 3.5 0.26 11.4 0.6 4.0 2 1 1 3 3 3 3 Receptor L domain DUF3971 PF13116.6 EFX01063.1 - 0.14 11.7 3.3 0.29 10.7 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function Clathrin_lg_ch PF01086.17 EFX01064.1 - 5.3e-72 242.6 8.1 5.9e-72 242.5 8.1 1.0 1 0 0 1 1 1 1 Clathrin light chain Metallophos PF00149.28 EFX01065.1 - 0.0052 17.3 1.1 0.025 15.1 1.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase ESSS PF10183.9 EFX01067.1 - 1.2e-15 57.6 0.0 1.5e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Vps5 PF09325.10 EFX01068.1 - 1.3e-85 286.7 5.2 1.7e-85 286.3 5.2 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EFX01068.1 - 1e-12 48.0 0.0 2.2e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 PX domain BAR_3 PF16746.5 EFX01068.1 - 0.00085 19.1 6.0 0.013 15.3 1.8 2.4 1 1 1 2 2 2 2 BAR domain of APPL family BAR_3_WASP_bdg PF10456.9 EFX01068.1 - 0.014 14.9 1.0 0.22 11.0 1.0 2.1 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein DUF713 PF05218.14 EFX01068.1 - 0.22 11.2 3.0 0.22 11.2 1.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF713) BAR PF03114.18 EFX01068.1 - 0.3 10.7 7.9 0.53 9.9 7.9 1.4 1 1 0 1 1 1 0 BAR domain CD99L2 PF12301.8 EFX01069.1 - 7.6e-05 23.1 0.0 0.0001 22.7 0.0 1.3 1 0 0 1 1 1 1 CD99 antigen like protein 2 LapA_dom PF06305.11 EFX01069.1 - 0.1 12.4 1.5 0.16 11.8 1.5 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Phage_holin_6_1 PF09682.10 EFX01069.1 - 0.14 12.6 0.6 0.2 12.1 0.6 1.2 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Amnionless PF14828.6 EFX01069.1 - 0.24 10.2 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Amnionless Methyltransf_11 PF08241.12 EFX01070.1 - 1.5e-17 64.1 0.0 3.4e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX01070.1 - 1.1e-14 54.6 0.0 1.6e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX01070.1 - 1.6e-14 54.4 0.1 5.4e-14 52.7 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01070.1 - 6e-13 49.4 0.1 2.2e-12 47.6 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01070.1 - 4.4e-12 46.1 0.1 1.7e-11 44.2 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFX01070.1 - 5.2e-11 42.3 0.0 7.1e-10 38.6 0.0 2.0 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EFX01070.1 - 3.3e-05 23.3 0.0 6.8e-05 22.3 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.12 EFX01070.1 - 0.001 18.6 0.0 0.0031 17.0 0.0 1.8 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_32 PF13679.6 EFX01070.1 - 0.008 16.2 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX01070.1 - 0.014 14.9 0.2 0.86 9.1 0.2 2.2 2 0 0 2 2 2 0 Methyltransferase small domain ADH_zinc_N PF00107.26 EFX01070.1 - 0.024 14.6 0.1 0.65 10.0 0.1 2.9 1 1 1 2 2 2 0 Zinc-binding dehydrogenase MetW PF07021.12 EFX01070.1 - 0.053 13.1 0.3 0.18 11.4 0.4 1.8 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Frag1 PF10277.9 EFX01071.1 - 3.4e-40 137.9 9.3 4e-40 137.7 9.3 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family FA_desaturase PF00487.24 EFX01071.1 - 0.62 9.9 12.8 0.3 10.9 4.4 2.4 1 1 1 2 2 2 0 Fatty acid desaturase Aminotran_1_2 PF00155.21 EFX01072.1 - 3.9e-34 118.4 0.0 5.4e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFX01072.1 - 0.09 11.3 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Peptidase_S28 PF05577.12 EFX01073.1 - 1.4e-45 155.9 1.1 9.6e-36 123.5 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 EFX01073.1 - 9.6e-06 24.5 0.1 2.5e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 PS-10 peptidase S37 DUF2920 PF11144.8 EFX01073.1 - 0.19 10.9 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) V-ATPase_C PF03223.15 EFX01074.1 - 9.4e-112 374.1 0.2 3.8e-86 289.8 0.3 2.0 1 1 1 2 2 2 2 V-ATPase subunit C DUF460 PF04312.13 EFX01074.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF460) ArsA_ATPase PF02374.15 EFX01075.1 - 1.7e-109 365.7 0.0 1.9e-109 365.5 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EFX01075.1 - 4.2e-13 49.6 0.2 5.3e-12 46.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EFX01075.1 - 3.6e-12 46.4 0.0 6.3e-12 45.7 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EFX01075.1 - 2.2e-06 27.3 1.1 0.00023 20.7 0.1 2.5 3 0 0 3 3 3 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 EFX01075.1 - 6.8e-06 25.7 0.0 1.2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 EFX01075.1 - 0.00011 21.9 0.0 0.0017 18.0 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EFX01075.1 - 0.00014 21.5 0.0 0.00032 20.2 0.0 1.6 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_16 PF13191.6 EFX01075.1 - 0.028 14.8 0.0 0.064 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 EFX01075.1 - 0.033 13.8 0.5 0.087 12.4 0.5 2.0 1 1 0 1 1 1 0 AAA domain LD_cluster3 PF18180.1 EFX01075.1 - 0.053 13.2 0.1 0.2 11.3 0.2 1.8 2 0 0 2 2 2 0 SLOG cluster3 family AAA_24 PF13479.6 EFX01075.1 - 0.095 12.4 0.1 1.4 8.6 0.1 2.3 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFX01075.1 - 0.13 11.5 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EFX01075.1 - 0.19 11.0 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin APH PF01636.23 EFX01076.1 - 0.00038 20.5 0.0 0.00038 20.5 0.0 3.2 3 1 1 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFX01076.1 - 0.0057 16.3 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EFX01076.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Cdh1_DBD_1 PF18196.1 EFX01076.1 - 0.9 9.9 5.1 6 7.2 5.1 2.6 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Borrelia_P83 PF05262.11 EFX01076.1 - 0.99 7.8 6.0 2.3 6.6 6.0 1.6 1 0 0 1 1 1 0 Borrelia P83/100 protein FTA2 PF13095.6 EFX01077.1 - 2.2e-07 30.7 0.0 0.0022 17.6 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Tim17 PF02466.19 EFX01079.1 - 1.4e-05 25.4 6.1 7.1e-05 23.2 3.1 2.2 1 1 1 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family HSP20 PF00011.21 EFX01080.1 - 1.6e-08 34.6 0.0 0.0088 16.2 0.1 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFX01080.1 - 0.0012 18.3 0.0 0.0057 16.2 0.0 2.0 2 0 0 2 2 2 1 HSP20-like domain found in ArsA Ribosomal_60s PF00428.19 EFX01080.1 - 1.7 9.3 17.6 6.6 7.4 9.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Mito_carr PF00153.27 EFX01081.1 - 6.8e-47 157.3 0.9 4.8e-16 58.5 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.16 EFX01082.1 - 1.7e-17 63.4 55.4 9.5e-10 37.9 36.5 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX01082.1 - 3.2e-06 25.9 25.2 4.3e-06 25.5 25.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) P5-ATPase PF12409.8 EFX01083.1 - 4.3e-41 139.9 0.0 1.1e-40 138.6 0.0 1.8 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EFX01083.1 - 8e-26 90.7 0.0 3.2e-25 88.7 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFX01083.1 - 3.7e-14 53.5 0.2 2.4e-06 28.0 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 EFX01083.1 - 8.2e-07 28.9 5.6 2.1e-06 27.6 5.6 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EFX01083.1 - 0.0051 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) SDA1 PF05285.12 EFX01083.1 - 2 7.8 8.8 3 7.2 8.8 1.1 1 0 0 1 1 1 0 SDA1 ADH_zinc_N_2 PF13602.6 EFX01084.1 - 1.5e-18 68.2 0.1 2.4e-18 67.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFX01084.1 - 4.6e-12 46.0 0.3 7.3e-12 45.4 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX01084.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Toxin_13 PF07822.11 EFX01084.1 - 0.16 12.1 0.3 0.38 10.9 0.0 1.7 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein KH_1 PF00013.29 EFX01085.1 - 2e-92 303.0 11.8 6.2e-13 48.4 0.1 13.2 15 0 0 15 15 15 9 KH domain KH_2 PF07650.17 EFX01085.1 - 3.8e-10 39.4 19.8 0.092 12.6 0.0 7.8 7 1 1 8 8 8 4 KH domain SLS PF14611.6 EFX01085.1 - 1.2e-09 38.4 5.5 0.0015 18.4 0.0 6.2 3 2 2 6 6 6 2 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 EFX01085.1 - 4.9e-06 26.3 9.3 0.14 12.1 0.0 6.4 7 0 0 7 7 7 2 KH domain DUF5300 PF17224.3 EFX01085.1 - 0.0028 17.9 1.2 2.4 8.5 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF5300) DUF1652 PF07865.11 EFX01085.1 - 0.018 14.9 0.1 4.9 7.0 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) BON PF04972.17 EFX01085.1 - 0.062 13.6 3.0 0.38 11.1 0.2 3.6 3 0 0 3 3 3 0 BON domain PHA_gran_rgn PF09650.10 EFX01085.1 - 2.2 8.6 8.0 16 5.9 0.2 4.3 5 0 0 5 5 5 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) NUDIX PF00293.28 EFX01086.1 - 4.3e-17 62.4 0.1 6.6e-17 61.8 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain SAP130_C PF16014.5 EFX01086.1 - 7.2 5.6 6.9 9.2 5.2 6.9 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Adaptin_N PF01602.20 EFX01087.1 - 2.5e-146 488.3 5.1 2.9e-146 488.1 5.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EFX01087.1 - 1.6e-18 67.1 0.0 4e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EFX01087.1 - 1.5e-08 34.8 7.0 0.00013 22.1 0.0 4.3 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF3730 PF12530.8 EFX01087.1 - 4.5e-05 23.1 0.4 0.0055 16.3 0.1 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3730) HEAT_2 PF13646.6 EFX01087.1 - 0.00059 20.2 6.3 0.33 11.4 0.0 4.3 6 1 0 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 EFX01087.1 - 0.015 15.8 1.0 54 4.4 0.0 5.3 7 0 0 7 7 7 0 HEAT-like repeat RIX1 PF08167.12 EFX01087.1 - 0.026 14.3 0.5 0.64 9.7 0.0 3.2 3 2 1 4 4 4 0 rRNA processing/ribosome biogenesis HEAT PF02985.22 EFX01087.1 - 0.038 14.3 4.1 13 6.4 0.1 4.8 5 0 0 5 5 5 0 HEAT repeat AT_hook PF02178.19 EFX01088.1 - 0.013 15.3 34.3 0.071 13.0 4.6 5.0 4 0 0 4 4 4 0 AT hook motif RBR PF17208.3 EFX01088.1 - 0.84 10.4 35.6 4.6 8.0 11.1 3.9 1 1 4 5 5 5 0 RNA binding Region COesterase PF00135.28 EFX01089.1 - 0.022 13.6 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Carboxylesterase family CsoS2_M PF12288.8 EFX01089.1 - 0.068 12.6 1.2 0.27 10.6 0.1 2.0 1 1 1 2 2 2 0 Carboxysome shell peptide mid-region RRM_1 PF00076.22 EFX01090.1 - 9e-21 73.5 0.0 2.3e-20 72.2 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFX01090.1 - 0.0002 20.9 0.0 0.00031 20.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gemini_mov PF01708.16 EFX01091.1 - 0.0075 16.0 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Geminivirus putative movement protein Suc_Fer-like PF06999.12 EFX01092.1 - 1.4e-64 217.6 0.0 1.7e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like zf-C2HE PF16278.5 EFX01093.1 - 3.3e-17 62.7 0.0 7.1e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 EFX01093.1 - 2.4e-14 53.8 0.1 6.4e-07 29.9 0.2 2.2 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EFX01093.1 - 3.3e-13 50.2 0.5 1.4e-12 48.2 0.5 1.9 1 1 0 1 1 1 1 HIT domain Mito_carr PF00153.27 EFX01094.1 - 1e-58 195.2 14.7 4.7e-21 74.5 0.1 4.9 4 1 0 4 4 4 3 Mitochondrial carrier protein Mito_carr PF00153.27 EFX01095.1 - 4.8e-42 141.8 6.3 2.3e-17 62.7 0.3 3.8 3 0 0 3 3 3 3 Mitochondrial carrier protein NAD_binding_6 PF08030.12 EFX01095.1 - 1.2e-31 110.0 0.0 2.8e-31 108.7 0.0 1.7 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFX01095.1 - 5.2e-21 74.8 0.2 1.4e-20 73.4 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EFX01095.1 - 2e-17 63.5 12.3 6.3e-17 61.9 12.3 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component HhH-GPD PF00730.25 EFX01096.1 - 1.9e-14 54.0 0.0 3.3e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EFX01096.1 - 1.1e-07 31.4 0.0 4.2e-07 29.5 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF3320 PF11784.8 EFX01096.1 - 0.071 13.1 0.3 0.19 11.7 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3320) Dicty_REP PF05086.12 EFX01096.1 - 0.12 10.3 0.7 0.16 9.9 0.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Flavokinase PF01687.17 EFX01097.1 - 2.5e-34 117.9 0.0 3.2e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase AA_permease PF00324.21 EFX01098.1 - 2e-102 343.3 42.7 2.3e-102 343.0 42.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX01098.1 - 4.6e-21 75.2 44.2 8.2e-21 74.3 44.2 1.4 1 1 0 1 1 1 1 Amino acid permease NUDIX PF00293.28 EFX01099.1 - 1.7e-05 24.9 0.0 4.4e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain MFS_1 PF07690.16 EFX01100.1 - 8.6e-40 136.7 37.3 8.6e-40 136.7 37.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Snf7 PF03357.21 EFX01101.1 - 2e-33 115.4 20.9 2e-33 115.4 20.9 2.0 1 1 1 2 2 2 1 Snf7 OTCace PF00185.24 EFX01101.1 - 0.0088 16.1 0.2 0.0088 16.1 0.2 2.0 1 1 1 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain DUF3138 PF11336.8 EFX01101.1 - 0.02 13.5 11.0 0.029 13.0 9.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) DUF4795 PF16043.5 EFX01101.1 - 0.13 11.8 21.1 0.94 9.0 20.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Fmp27_WPPW PF10359.9 EFX01101.1 - 5.5 5.7 11.6 4.3 6.1 10.5 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Dfp1_Him1_M PF08630.10 EFX01102.1 - 2.9e-42 143.9 0.2 2.3e-41 140.9 0.0 2.6 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EFX01102.1 - 1.1e-20 73.5 1.0 1.1e-20 73.5 1.0 1.9 2 0 0 2 2 2 1 DBF zinc finger BRCT PF00533.26 EFX01102.1 - 0.023 15.1 0.0 0.054 13.9 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFX01102.1 - 0.097 12.6 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain Sh_2 PF17512.2 EFX01102.1 - 0.13 12.0 0.5 0.31 10.8 0.5 1.6 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein Arm PF00514.23 EFX01103.1 - 1.3e-96 314.1 17.1 7.7e-14 51.2 0.2 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EFX01103.1 - 6e-28 97.1 1.6 1.6e-27 95.7 1.6 1.8 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 EFX01103.1 - 4.9e-24 83.7 4.9 1.5e-23 82.1 3.6 2.2 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EFX01103.1 - 4.4e-22 78.2 11.8 2e-09 37.7 0.1 6.7 6 1 1 7 7 7 4 HEAT-like repeat HEAT_2 PF13646.6 EFX01103.1 - 2.4e-19 69.5 0.1 2.6e-09 37.3 0.0 5.3 1 1 2 4 4 4 3 HEAT repeats HEAT PF02985.22 EFX01103.1 - 1.9e-18 64.9 2.9 3.5e-06 26.8 0.0 7.2 8 0 0 8 8 8 4 HEAT repeat Arm_2 PF04826.13 EFX01103.1 - 4e-09 36.3 0.0 0.012 15.0 0.0 4.1 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.20 EFX01103.1 - 5.7e-06 25.2 0.0 0.00062 18.5 0.0 2.7 1 1 0 2 2 2 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 EFX01103.1 - 3.1e-05 24.0 0.0 1.8 8.7 0.0 4.5 3 2 2 5 5 5 2 V-ATPase subunit H HEAT_PBS PF03130.16 EFX01103.1 - 0.00026 21.4 0.1 0.8 10.6 0.0 4.6 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Cnd1 PF12717.7 EFX01103.1 - 0.0021 18.1 0.0 2.8 8.0 0.0 2.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 NopRA1 PF16201.5 EFX01103.1 - 0.0051 16.4 0.0 2.4 7.7 0.0 3.9 1 1 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 EFX01103.1 - 0.027 14.7 5.4 1.6 9.0 0.1 4.7 3 2 3 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 Glycos_trans_3N PF02885.17 EFX01103.1 - 0.078 12.8 0.0 7.2 6.5 0.0 3.2 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain Gcn1_N PF12074.8 EFX01103.1 - 0.15 11.3 0.0 9.2 5.4 0.0 2.7 2 1 1 3 3 3 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal NUSAP PF16006.5 EFX01103.1 - 6.9 6.3 6.4 9.6 5.9 6.4 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein TrbC PF04956.13 EFX01104.1 - 0.055 13.7 2.4 5.4 7.3 0.8 2.3 1 1 1 2 2 2 0 TrbC/VIRB2 family DUF2975 PF11188.8 EFX01104.1 - 0.058 13.3 5.4 0.19 11.6 5.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) LapA_dom PF06305.11 EFX01104.1 - 0.071 12.9 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain G0-G1_switch_2 PF15103.6 EFX01104.1 - 0.19 12.2 0.0 0.33 11.4 0.0 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 ANAPC4_WD40 PF12894.7 EFX01105.1 - 0.00029 21.1 0.1 0.03 14.6 0.1 3.4 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFX01105.1 - 0.00096 19.9 1.4 0.00096 19.9 1.4 5.9 6 0 0 6 6 6 1 WD domain, G-beta repeat Ribosomal_L37ae PF01780.19 EFX01105.1 - 0.13 12.4 7.1 0.023 14.8 2.3 2.3 2 0 0 2 2 2 0 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EFX01105.1 - 1.3 9.1 8.6 0.16 12.0 1.7 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EFX01105.1 - 2.7 8.0 7.4 0.56 10.2 0.8 2.6 2 1 0 2 2 2 0 Putative transposase DNA-binding domain WD40 PF00400.32 EFX01106.1 - 5.4e-12 46.0 4.3 0.22 12.4 0.1 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat Kin17_mid PF10357.9 EFX01107.1 - 2.8e-50 169.5 0.7 2.8e-50 169.5 0.7 2.2 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 EFX01107.1 - 5.9e-05 23.2 0.3 0.00014 22.1 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX01107.1 - 0.00061 20.1 0.7 0.0014 18.9 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DndB PF14072.6 EFX01107.1 - 0.018 14.2 1.6 0.024 13.9 1.6 1.1 1 0 0 1 1 1 0 DNA-sulfur modification-associated zf-C2H2_2 PF12756.7 EFX01107.1 - 0.023 15.1 1.6 0.062 13.6 0.1 2.2 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) LIP1 PF15904.5 EFX01107.1 - 0.052 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 LKB1 serine/threonine kinase interacting protein 1 Methyltransf_7 PF03492.15 EFX01107.1 - 0.094 11.9 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase Pro_Al_protease PF02983.14 EFX01108.1 - 0.3 11.2 9.8 1.8 8.7 0.4 4.3 4 0 0 4 4 4 0 Alpha-lytic protease prodomain Autophagy_act_C PF03987.15 EFX01109.1 - 4e-12 46.5 0.2 7.8e-12 45.6 0.2 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Peptidase_M1 PF01433.20 EFX01110.1 - 3e-43 147.9 0.1 4.4e-43 147.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EFX01110.1 - 3.5e-36 123.7 0.0 6.4e-36 122.9 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EFX01110.1 - 2.4e-06 27.8 0.0 0.00013 22.2 0.0 2.3 1 1 1 2 2 2 1 Peptidase M1 N-terminal domain Peptidase_MA_2 PF13485.6 EFX01110.1 - 0.11 12.2 0.8 0.69 9.5 0.8 2.0 1 1 0 1 1 1 0 Peptidase MA superfamily Peptidase_M61 PF05299.12 EFX01110.1 - 0.58 10.6 2.2 11 6.4 2.2 2.5 1 1 0 1 1 1 0 M61 glycyl aminopeptidase K_channel_TID PF07941.11 EFX01111.1 - 0.12 12.8 2.8 0.27 11.7 2.8 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF3632 PF12311.8 EFX01112.1 - 0.087 13.3 0.0 0.16 12.4 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3632) Pkinase PF00069.25 EFX01113.1 - 2.1e-16 60.1 0.0 3.1e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01113.1 - 2.5e-06 27.0 0.0 4.9e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DCB PF16213.5 EFX01113.1 - 0.14 11.8 0.1 0.75 9.4 0.0 2.0 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 AAA_18 PF13238.6 EFX01114.1 - 6.1e-25 88.3 0.0 8.7e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFX01114.1 - 5.8e-05 23.5 0.0 0.00032 21.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFX01114.1 - 0.00014 22.3 0.0 0.00086 19.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFX01114.1 - 0.00032 21.0 0.1 0.0016 18.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX01114.1 - 0.0014 18.9 0.2 0.0063 16.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX01114.1 - 0.0022 18.4 0.1 0.0072 16.7 0.1 1.9 1 1 0 2 2 2 1 AAA ATPase domain Thymidylate_kin PF02223.17 EFX01114.1 - 0.0028 17.3 0.1 2 8.1 0.1 2.1 2 0 0 2 2 2 2 Thymidylate kinase NTPase_1 PF03266.15 EFX01114.1 - 0.0035 17.3 0.1 0.0065 16.4 0.1 1.4 1 0 0 1 1 1 1 NTPase AAA_33 PF13671.6 EFX01114.1 - 0.0038 17.4 0.5 0.46 10.6 0.3 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 EFX01114.1 - 0.0041 17.5 1.3 0.0064 16.8 0.4 1.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFX01114.1 - 0.0044 16.1 0.1 0.0078 15.3 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EFX01114.1 - 0.02 14.6 2.7 0.14 11.8 0.9 2.3 1 1 1 2 2 2 0 AAA domain DUF927 PF06048.11 EFX01114.1 - 0.03 13.9 0.1 7.1 6.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF927) IstB_IS21 PF01695.17 EFX01114.1 - 0.031 14.0 0.0 0.065 13.0 0.0 1.5 2 0 0 2 2 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 EFX01114.1 - 0.036 13.4 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family ADK PF00406.22 EFX01114.1 - 0.037 14.1 0.0 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 Adenylate kinase DUF2075 PF09848.9 EFX01114.1 - 0.044 13.0 0.9 0.33 10.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EFX01114.1 - 0.097 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EFX01114.1 - 0.097 12.4 0.0 0.31 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EFX01114.1 - 0.13 11.7 0.0 0.58 9.6 0.0 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EFX01114.1 - 0.16 10.9 0.2 0.3 10.0 0.2 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Pkinase PF00069.25 EFX01115.1 - 9.5e-73 244.8 0.0 2.6e-72 243.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01115.1 - 4.5e-49 167.0 0.0 8e-49 166.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX01115.1 - 0.00022 20.1 0.0 0.00037 19.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFX01115.1 - 0.0082 15.5 0.0 0.089 12.1 0.1 2.1 2 0 0 2 2 2 1 Kinase-like DUF2321 PF10083.9 EFX01115.1 - 0.018 14.7 0.1 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) PAP2 PF01569.21 EFX01116.1 - 4.5e-19 68.6 5.1 1.1e-18 67.3 1.0 3.0 2 2 0 2 2 2 1 PAP2 superfamily Sec10 PF07393.11 EFX01117.1 - 5.7e-148 494.4 0.0 6.4e-106 355.5 0.0 2.3 2 1 0 2 2 2 2 Exocyst complex component Sec10 F-box-like PF12937.7 EFX01117.1 - 3.1e-06 27.0 0.6 7.7e-06 25.7 0.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFX01117.1 - 4.1e-06 26.5 0.2 7.9e-06 25.6 0.2 1.4 1 0 0 1 1 1 1 F-box domain Xan_ur_permease PF00860.20 EFX01118.1 - 9e-10 37.8 5.8 9e-10 37.8 5.8 1.9 1 1 1 2 2 2 1 Permease family Sulfate_transp PF00916.20 EFX01118.1 - 0.052 12.3 7.0 0.013 14.3 2.8 2.0 2 1 1 3 3 3 0 Sulfate permease family 2TM PF13239.6 EFX01118.1 - 5.7 7.3 6.1 0.56 10.5 0.1 2.2 2 0 0 2 2 2 0 2TM domain Ank_4 PF13637.6 EFX01119.1 - 1.4e-14 54.2 0.6 3.3e-09 37.1 0.1 2.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX01119.1 - 8.2e-12 45.6 0.0 1.7e-11 44.5 0.0 1.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFX01119.1 - 1.6e-10 40.9 0.5 6e-08 32.8 0.6 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFX01119.1 - 3.4e-10 40.0 0.3 8.1e-10 38.8 0.2 1.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01119.1 - 4.3e-10 38.9 0.0 7.6e-07 29.0 0.1 2.6 3 0 0 3 3 3 2 Ankyrin repeat ArfGap PF01412.18 EFX01120.1 - 1.4e-40 138.0 0.4 2e-40 137.5 0.4 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf partial_CstF PF15861.5 EFX01120.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain AidB_N PF18158.1 EFX01121.1 - 6.1e-16 58.7 0.0 1.3e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFX01121.1 - 2.4e-13 50.6 0.3 4.5e-12 46.4 0.1 2.9 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFX01121.1 - 2.3e-09 37.3 0.0 5.5e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Glyco_transf_41 PF13844.6 EFX01123.1 - 9e-80 268.4 0.7 5.1e-48 163.7 0.0 4.3 2 2 2 4 4 4 4 Glycosyl transferase family 41 TPR_1 PF00515.28 EFX01123.1 - 4e-17 61.2 2.5 0.018 14.8 0.0 6.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFX01123.1 - 1.1e-14 53.3 3.4 0.0035 17.3 0.0 6.6 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFX01123.1 - 1.1e-10 40.8 0.1 0.031 14.5 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX01123.1 - 3e-09 36.5 6.2 0.33 10.9 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFX01123.1 - 4.1e-09 36.6 3.8 0.084 13.2 0.0 5.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFX01123.1 - 5.7e-08 32.6 0.1 0.09 13.2 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX01123.1 - 8.2e-07 29.3 0.4 2 9.4 0.0 5.8 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01123.1 - 1.8e-06 28.4 1.0 0.0057 17.3 0.0 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFX01123.1 - 2e-05 24.2 2.5 0.078 12.7 0.0 5.1 3 1 2 5 5 5 1 TPR repeat TPR_19 PF14559.6 EFX01123.1 - 3.4e-05 24.3 0.8 1.1 9.8 0.1 4.4 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFX01123.1 - 0.00044 20.1 0.0 0.9 9.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat PknG_TPR PF16918.5 EFX01123.1 - 0.0029 16.4 0.0 0.0057 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_9 PF13371.6 EFX01123.1 - 0.0075 16.4 0.1 6.6 7.0 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFX01123.1 - 0.017 14.3 0.0 7.3 5.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Rho_N PF07498.12 EFX01124.1 - 6.2e-05 22.8 0.2 0.00012 21.9 0.2 1.5 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain Glyco_hydro_76 PF03663.14 EFX01125.1 - 5.6e-140 467.0 20.1 7.2e-140 466.6 20.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 VSP PF03302.13 EFX01125.1 - 0.051 12.4 1.1 0.085 11.7 1.1 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein SPX PF03105.19 EFX01127.1 - 3.5 7.4 6.7 4.4 7.1 6.7 1.1 1 0 0 1 1 1 0 SPX domain Zn_clus PF00172.18 EFX01128.1 - 0.00011 22.2 10.9 0.00023 21.2 10.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX01128.1 - 0.27 10.2 4.3 0.11 11.5 0.6 2.1 2 0 0 2 2 2 0 Fungal specific transcription factor domain Ank_2 PF12796.7 EFX01129.1 - 2.7e-40 136.8 0.1 1.6e-14 54.2 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFX01129.1 - 9.5e-35 118.2 3.1 9.1e-10 38.6 0.0 4.9 1 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFX01129.1 - 2.1e-34 117.4 8.1 1.1e-08 35.4 0.0 5.0 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01129.1 - 8.4e-28 93.4 0.1 7.6e-05 22.8 0.0 6.1 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EFX01129.1 - 2.3e-25 87.9 1.3 9.6e-05 22.7 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat p450 PF00067.22 EFX01133.1 - 2.1e-46 158.6 0.0 2.1e-44 152.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 HhH-GPD PF00730.25 EFX01134.1 - 2.3e-14 53.8 0.0 5.1e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein SRP_TPR_like PF17004.5 EFX01135.1 - 8e-15 54.9 0.0 2.9e-14 53.1 0.0 2.0 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 EFX01135.1 - 6.2e-14 52.2 4.6 6.2e-14 52.2 4.6 1.9 2 0 0 2 2 2 1 SRP72 RNA-binding domain Ribosomal_60s PF00428.19 EFX01135.1 - 0.0068 17.0 5.4 0.0068 17.0 5.4 4.2 3 1 0 3 3 3 1 60s Acidic ribosomal protein TPR_12 PF13424.6 EFX01135.1 - 0.01 16.1 2.0 0.01 16.1 2.0 6.0 4 2 0 5 5 5 0 Tetratricopeptide repeat SPO22 PF08631.10 EFX01135.1 - 0.064 12.7 0.0 0.27 10.7 0.0 2.0 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like adh_short PF00106.25 EFX01136.1 - 0.0005 19.6 0.0 0.066 12.7 0.0 3.3 3 0 0 3 3 3 1 short chain dehydrogenase Metal_resist PF13801.6 EFX01136.1 - 0.019 15.2 0.3 3.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Heavy-metal resistance MSC PF09402.10 EFX01137.1 - 7.7e-114 380.7 0.0 1.1e-113 380.2 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EFX01137.1 - 1.2e-12 47.4 0.0 1.9e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 HeH/LEM domain Thymopoietin PF08198.11 EFX01137.1 - 0.018 14.6 0.0 0.038 13.6 0.0 1.5 1 0 0 1 1 1 0 Thymopoietin protein AA_permease_2 PF13520.6 EFX01139.1 - 1.1e-87 294.6 40.0 1.3e-87 294.4 40.0 1.0 1 0 0 1 1 1 1 Amino acid permease Tetraspanin PF00335.20 EFX01139.1 - 3 7.5 13.5 0.08 12.6 2.0 3.2 3 0 0 3 3 3 0 Tetraspanin family Sec39 PF08314.11 EFX01140.1 - 1.5e-271 903.2 0.0 1.8e-271 903.0 0.0 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Ribosomal_S9 PF00380.19 EFX01142.1 - 3.5e-41 140.5 1.7 6e-41 139.8 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Synaptobrevin PF00957.21 EFX01143.1 - 0.022 14.5 0.4 0.12 12.2 0.2 1.9 1 1 1 2 2 2 0 Synaptobrevin MFS_1 PF07690.16 EFX01144.1 - 2.7e-23 82.5 37.8 2.7e-23 82.5 37.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cu-oxidase_3 PF07732.15 EFX01145.1 - 3.7e-39 133.4 1.9 1.7e-37 128.1 0.2 3.1 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX01145.1 - 7.7e-32 109.9 5.2 1.4e-29 102.5 0.6 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX01145.1 - 2.7e-14 53.6 0.0 1.5e-13 51.1 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase Zn_clus PF00172.18 EFX01147.1 - 6.5e-07 29.4 6.5 6.5e-07 29.4 6.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX01147.1 - 0.086 11.9 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Dickkopf_N PF04706.12 EFX01147.1 - 2.9 8.5 7.6 6.9 7.2 7.6 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Fapy_DNA_glyco PF01149.24 EFX01148.1 - 4.7e-34 117.5 0.0 8.2e-34 116.7 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EFX01148.1 - 3.9e-20 71.6 0.0 7.3e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Alpha-L-AF_C PF06964.12 EFX01149.1 - 7.9e-29 100.9 0.0 1.3e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain zf-RING_4 PF14570.6 EFX01150.1 - 1.3e-19 69.7 12.9 2.3e-19 68.9 12.9 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EFX01150.1 - 1.4e-09 37.6 0.0 4.9e-09 35.9 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EFX01150.1 - 1.1e-07 31.6 8.1 2.1e-07 30.7 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EFX01150.1 - 0.00028 20.4 4.1 0.00028 20.4 4.1 4.2 3 1 0 3 3 3 1 Rtf2 RING-finger SET_assoc PF11767.8 EFX01150.1 - 0.0025 17.4 0.0 0.0055 16.3 0.0 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Prok-RING_4 PF14447.6 EFX01150.1 - 0.029 14.2 10.9 0.78 9.7 11.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.11 EFX01150.1 - 0.034 14.1 5.3 0.068 13.1 5.3 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Nup35_RRM_2 PF14605.6 EFX01150.1 - 0.065 13.2 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-UDP PF14569.6 EFX01150.1 - 0.25 11.5 4.3 0.77 9.9 4.3 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4 PF00097.25 EFX01150.1 - 0.28 11.1 11.6 0.66 9.9 11.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.16 EFX01151.1 - 3.4e-30 105.2 31.2 3.4e-30 105.2 31.2 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily LapA_dom PF06305.11 EFX01151.1 - 0.4 10.5 2.4 1.5 8.7 0.0 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain HLH PF00010.26 EFX01152.1 - 5.2e-09 35.9 0.1 1.1e-08 34.9 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TMF_TATA_bd PF12325.8 EFX01153.1 - 3.4e-38 130.4 7.6 3.4e-38 130.4 7.6 6.8 4 2 2 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EFX01153.1 - 1.6e-15 56.8 10.4 1.6e-15 56.8 10.4 9.0 5 3 3 9 9 9 1 TATA element modulatory factor 1 DNA binding XhlA PF10779.9 EFX01153.1 - 0.1 12.9 0.1 0.1 12.9 0.1 7.1 7 2 2 9 9 9 0 Haemolysin XhlA Sacchrp_dh_C PF16653.5 EFX01154.1 - 9.5e-95 317.7 0.0 2.7e-94 316.2 0.0 1.8 2 1 0 2 2 2 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EFX01154.1 - 6.1e-26 91.2 0.6 9.7e-26 90.6 0.6 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFX01154.1 - 4.4e-06 26.8 0.2 1.2e-05 25.4 0.2 1.8 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EFX01154.1 - 0.00048 20.1 0.3 0.00095 19.1 0.3 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_3 PF03447.16 EFX01154.1 - 0.00065 20.3 0.4 0.0012 19.5 0.4 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain IlvN PF07991.12 EFX01154.1 - 0.0015 18.1 0.8 0.0088 15.6 0.2 2.4 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA PF01408.22 EFX01154.1 - 0.04 14.8 0.1 0.083 13.7 0.1 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold SieB PF14163.6 EFX01154.1 - 0.15 11.6 0.0 0.38 10.3 0.0 1.6 1 0 0 1 1 1 0 Super-infection exclusion protein B CN_hydrolase PF00795.22 EFX01156.1 - 1.2e-37 129.7 0.0 1.6e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EFX01156.1 - 5.1e-19 68.4 0.0 8.1e-18 64.4 0.0 2.5 1 1 0 1 1 1 1 NAD synthase BPS PF08947.10 EFX01156.1 - 0.086 12.7 0.3 0.85 9.5 0.0 2.3 2 0 0 2 2 2 0 BPS (Between PH and SH2) Hexapep PF00132.24 EFX01157.1 - 5.1e-12 45.0 11.2 2.2e-06 27.1 1.3 3.6 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFX01157.1 - 0.00025 20.7 3.6 0.056 13.2 1.6 3.6 2 1 2 4 4 4 4 Hexapeptide repeat of succinyl-transferase Ten1 PF12658.7 EFX01158.1 - 3.7e-20 72.1 0.0 4.3e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Telomere capping, CST complex subunit DASH_Duo1 PF08651.10 EFX01159.1 - 2.1e-28 97.9 0.3 2.9e-28 97.4 0.3 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 DASH_Dad2 PF08654.10 EFX01159.1 - 0.15 12.5 1.9 0.31 11.5 1.9 1.5 1 1 0 1 1 1 0 DASH complex subunit Dad2 DUF745 PF05335.13 EFX01159.1 - 0.24 11.1 8.3 0.48 10.1 8.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF1682 PF07946.14 EFX01159.1 - 0.76 8.9 3.6 1 8.5 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Rrn6 PF10214.9 EFX01159.1 - 5 5.5 13.5 5.6 5.3 13.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor NIF PF03031.18 EFX01160.1 - 5e-21 75.1 0.0 7.1e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2063 PF09836.9 EFX01160.1 - 0.14 12.4 0.1 31 4.9 0.0 2.6 2 1 0 2 2 2 0 Putative DNA-binding domain DNA_primase_lrg PF04104.14 EFX01161.1 - 1.3e-84 283.7 0.0 2.3e-84 283.0 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Motile_Sperm PF00635.26 EFX01162.1 - 3.8e-24 84.6 0.1 1.2e-23 83.0 0.1 1.8 1 1 1 2 2 2 1 MSP (Major sperm protein) domain ASH PF15780.5 EFX01162.1 - 0.096 12.9 0.1 0.25 11.5 0.1 1.7 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Cyclin_N PF00134.23 EFX01163.1 - 1.2e-44 151.1 0.1 2.6e-44 150.0 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFX01163.1 - 2.2e-33 114.9 0.0 5e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_L2_C PF03947.18 EFX01164.1 - 2.6e-50 169.8 3.3 5.3e-50 168.8 2.7 1.9 2 1 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFX01164.1 - 5.7e-25 87.1 0.3 1.2e-24 86.0 0.3 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DEC-1_N PF04625.13 EFX01164.1 - 0.00013 21.1 2.9 0.00019 20.6 2.9 1.1 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region p450 PF00067.22 EFX01165.1 - 1.9e-38 132.4 0.0 2.3e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_2 PF13347.6 EFX01167.1 - 1.8e-06 26.8 10.1 1.8e-06 26.8 10.1 2.4 2 1 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 EFX01167.1 - 9.4e-05 21.4 3.2 9.6e-05 21.4 1.8 1.7 2 0 0 2 2 2 1 MFS_1 like family Ribosomal_L11_N PF03946.14 EFX01169.1 - 4.9e-25 87.2 0.2 8.1e-25 86.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EFX01169.1 - 8.7e-16 58.2 0.1 1.5e-15 57.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain IF2_N PF04760.15 EFX01169.1 - 0.041 13.7 0.1 0.3 11.0 0.1 2.5 1 1 1 2 2 2 0 Translation initiation factor IF-2, N-terminal region Met_asp_mut_E PF06368.11 EFX01169.1 - 0.12 10.8 0.1 0.15 10.5 0.1 1.0 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) zf-rbx1 PF12678.7 EFX01170.1 - 6.5e-09 36.0 6.2 1.2e-08 35.1 6.2 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFX01170.1 - 2.1e-08 34.4 5.7 4.1e-08 33.4 5.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFX01170.1 - 1.3e-05 24.9 4.5 0.0002 21.2 1.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX01170.1 - 1.7e-05 24.8 1.4 3.3e-05 23.8 1.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFX01170.1 - 2e-05 24.5 2.9 5.6e-05 23.0 3.0 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFX01170.1 - 0.00015 21.6 4.3 0.00026 20.8 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX01170.1 - 0.00043 20.1 3.5 0.001 18.9 3.5 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EFX01170.1 - 0.00087 18.9 0.5 0.0022 17.6 0.5 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EFX01170.1 - 0.0015 18.3 2.3 0.0015 18.3 2.3 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Pox_T4_C PF04490.12 EFX01170.1 - 0.018 15.2 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus zf-ANAPC11 PF12861.7 EFX01170.1 - 0.022 14.8 3.9 0.061 13.4 3.9 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EFX01170.1 - 0.054 13.7 1.1 0.11 12.7 1.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EFX01170.1 - 0.2 11.5 3.4 0.53 10.1 3.4 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EFX01170.1 - 1.8 8.8 4.1 11 6.2 4.1 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Ion_trans_2 PF07885.16 EFX01171.1 - 2.3e-31 107.6 25.2 9.9e-18 63.9 5.2 3.1 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EFX01171.1 - 0.00097 18.4 14.6 0.031 13.5 1.2 3.2 2 1 1 3 3 3 2 Ion transport protein CDC45 PF02724.14 EFX01171.1 - 0.19 10.0 3.0 0.28 9.4 3.0 1.3 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 EFX01171.1 - 1.8 8.9 13.9 5.6 7.2 13.9 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 EFX01171.1 - 5.5 5.1 9.2 7.8 4.6 9.2 1.1 1 0 0 1 1 1 0 Nop14-like family DUF996 PF06195.13 EFX01171.1 - 6.3 7.1 8.3 1.4 9.2 3.9 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF996) Ham1p_like PF01725.16 EFX01172.1 - 1.2e-57 194.9 0.0 1.4e-57 194.6 0.0 1.1 1 0 0 1 1 1 1 Ham1 family p450 PF00067.22 EFX01173.1 - 7.8e-49 166.7 0.0 1.2e-48 166.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L4 PF00573.22 EFX01174.1 - 1.7e-32 112.6 0.1 2.3e-32 112.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EFX01174.1 - 2.9e-15 56.1 1.0 7e-15 54.9 1.0 1.7 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain PIF1 PF05970.14 EFX01174.1 - 0.059 12.5 0.1 0.086 12.0 0.1 1.1 1 0 0 1 1 1 0 PIF1-like helicase CAS_CSE1 PF03378.15 EFX01175.1 - 1.3e-177 590.8 0.0 2.5e-177 589.9 0.0 1.5 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EFX01175.1 - 2.2e-150 500.6 0.5 3.1e-150 500.1 0.5 1.2 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EFX01175.1 - 1.5e-15 56.9 0.0 4.1e-15 55.4 0.0 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFX01175.1 - 7.3e-05 22.9 0.4 0.0075 16.3 0.0 3.9 3 1 1 4 4 4 1 Exportin 1-like protein DUF3295 PF11702.8 EFX01176.1 - 9.1e-148 493.7 36.9 3.2e-123 412.7 29.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3295) DUF1752 PF08550.10 EFX01176.1 - 8.2e-07 28.7 3.2 1.6e-06 27.8 3.2 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Pribosyltran PF00156.27 EFX01177.1 - 3.8e-14 52.5 0.0 5.3e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFX01177.1 - 0.0004 19.9 0.0 0.00055 19.4 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase TauD PF02668.16 EFX01178.1 - 1.9e-50 172.2 1.1 3.5e-50 171.3 1.1 1.4 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family GRDP-like PF07173.12 EFX01178.1 - 1.6e-16 61.2 0.8 2.9e-13 50.7 0.0 2.8 2 0 0 2 2 2 2 Glycine-rich domain-containing protein-like APS_kinase PF01583.20 EFX01179.1 - 2.9e-71 238.5 0.0 1.8e-70 235.9 0.0 2.2 2 0 0 2 2 2 1 Adenylylsulphate kinase MutS_V PF00488.21 EFX01179.1 - 4.3e-47 160.6 0.0 4.3e-47 160.6 0.0 2.0 2 0 0 2 2 2 1 MutS domain V AAA_33 PF13671.6 EFX01179.1 - 1.3e-07 31.9 3.4 0.0001 22.5 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EFX01179.1 - 0.0002 21.9 0.0 0.0026 18.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFX01179.1 - 0.00024 20.8 0.0 1.2 8.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain KTI12 PF08433.10 EFX01179.1 - 0.00086 18.8 0.9 0.0084 15.6 0.0 2.5 3 0 0 3 3 3 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EFX01179.1 - 0.0013 19.2 0.1 1 9.7 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain Macoilin PF09726.9 EFX01179.1 - 0.012 14.2 3.0 0.016 13.8 3.0 1.1 1 0 0 1 1 1 0 Macoilin family RNA_helicase PF00910.22 EFX01179.1 - 0.016 15.6 0.0 6.9 7.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Motile_Sperm PF00635.26 EFX01179.1 - 0.037 13.9 1.5 0.074 12.9 1.5 1.4 1 0 0 1 1 1 0 MSP (Major sperm protein) domain G-alpha PF00503.20 EFX01179.1 - 0.055 12.6 0.0 3.7 6.6 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_14 PF13173.6 EFX01179.1 - 0.15 12.1 0.0 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF572 PF04502.13 EFX01179.1 - 4.9 6.7 8.7 7.7 6.0 8.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) BAF1_ABF1 PF04684.13 EFX01179.1 - 8.2 5.4 14.4 13 4.7 14.4 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF5308 PF17233.2 EFX01180.1 - 5.1e-26 91.9 0.6 1.4e-15 58.0 0.1 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5308) RanGAP1_C PF07834.11 EFX01180.1 - 0.072 12.7 0.0 0.2 11.3 0.0 1.6 2 0 0 2 2 2 0 RanGAP1 C-terminal domain Apolipoprotein PF01442.18 EFX01181.1 - 0.0095 15.8 2.3 0.012 15.6 2.3 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.7 EFX01181.1 - 0.15 12.6 13.0 81 3.9 13.0 2.3 1 1 0 1 1 1 0 YtxH-like protein Uds1 PF15456.6 EFX01181.1 - 1.3 9.2 6.0 0.81 9.9 4.0 1.7 1 1 1 2 2 2 0 Up-regulated During Septation DivIVA PF05103.13 EFX01181.1 - 1.3 9.1 8.4 0.77 9.8 3.4 2.1 1 1 1 2 2 2 0 DivIVA protein DUF883 PF05957.13 EFX01181.1 - 1.5 9.5 6.6 2.2 8.9 3.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) FAD_binding_1 PF00667.20 EFX01182.1 - 1.6e-43 148.8 0.0 2.4e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EFX01182.1 - 1.1e-09 38.8 0.0 5.5e-09 36.6 0.0 2.2 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain FA_desaturase PF00487.24 EFX01183.1 - 7.6e-20 71.8 24.7 7.6e-20 71.8 24.7 1.9 1 1 1 2 2 2 1 Fatty acid desaturase MgtE PF01769.16 EFX01183.1 - 0.89 9.9 4.5 2.2 8.6 0.2 2.2 2 0 0 2 2 2 0 Divalent cation transporter UQ_con PF00179.26 EFX01184.1 - 2.5e-37 127.7 0.0 3e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EFX01184.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.4 1 1 0 1 1 1 0 UEV domain PHD PF00628.29 EFX01185.1 - 2.7e-08 33.6 9.6 5.5e-08 32.6 9.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFX01185.1 - 0.0019 17.7 5.3 0.0037 16.8 5.3 1.5 1 0 0 1 1 1 1 PHD-finger DUF3614 PF12267.8 EFX01185.1 - 0.8 10.2 4.3 0.25 11.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3614) Glyco_hydro_28 PF00295.17 EFX01186.1 - 1.8e-49 168.6 1.2 3e-49 167.8 1.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 End_N_terminal PF12218.8 EFX01186.1 - 0.025 14.3 0.0 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase Ribonuc_L-PSP PF01042.21 EFX01187.1 - 3.7e-18 65.7 0.1 4.6e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP NOGCT PF08155.11 EFX01187.1 - 0.093 12.7 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 NOGCT (NUC087) domain DUF1761 PF08570.10 EFX01188.1 - 6.2e-26 91.1 1.7 7e-26 90.9 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Glucosamine_iso PF01182.20 EFX01189.1 - 1.1e-18 68.0 0.0 1.8e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase FTR1 PF03239.14 EFX01190.1 - 3.5e-80 269.4 9.4 4.1e-80 269.2 9.4 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Phage_holin_3_6 PF07332.11 EFX01190.1 - 0.0026 17.8 0.9 0.0026 17.8 0.9 2.5 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III Toxin_4 PF00706.17 EFX01190.1 - 3.1 8.3 6.4 13 6.3 6.4 2.1 1 1 0 1 1 1 0 Anenome neurotoxin SUZ PF12752.7 EFX01192.1 - 0.072 13.9 3.2 0.072 13.9 3.2 2.9 2 1 0 2 2 2 0 SUZ domain Abhydrolase_1 PF00561.20 EFX01193.1 - 4.7e-16 59.2 0.0 2e-14 53.9 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX01193.1 - 8.7e-06 25.2 0.0 0.00061 19.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 EFX01193.1 - 0.0024 17.6 0.0 0.0033 17.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 EFX01193.1 - 0.043 13.6 0.0 0.068 13.0 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase VHS PF00790.19 EFX01194.1 - 1.1e-25 90.1 0.0 2.3e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EFX01194.1 - 0.0052 17.0 1.4 0.015 15.6 1.4 1.8 1 0 0 1 1 1 1 GAT domain SPRY PF00622.28 EFX01195.1 - 1.5e-18 67.0 0.0 2.4e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain HAD_2 PF13419.6 EFX01196.1 - 3e-16 60.0 0.0 4.3e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFX01196.1 - 1.1e-05 25.9 0.0 6.7e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX01196.1 - 0.0001 22.3 0.0 0.00029 20.8 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like NIF PF03031.18 EFX01196.1 - 0.15 11.9 0.0 3.2 7.5 0.0 2.1 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase Hydrolase_6 PF13344.6 EFX01196.1 - 0.18 12.0 0.0 3.7 7.7 0.0 2.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase OB_NTP_bind PF07717.16 EFX01197.1 - 6.8e-14 52.0 0.0 1.3e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFX01197.1 - 2e-13 50.6 0.0 3.8e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 EFX01197.1 - 8.7e-11 42.1 1.4 5.5e-10 39.5 0.1 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.29 EFX01197.1 - 3e-07 30.4 0.0 1e-06 28.6 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 EFX01197.1 - 0.006 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RWD PF05773.22 EFX01197.1 - 0.013 15.8 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 RWD domain AAA_22 PF13401.6 EFX01197.1 - 0.02 15.2 0.2 7.7 6.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain IHABP4_N PF16174.5 EFX01197.1 - 0.022 15.3 0.1 0.022 15.3 0.1 2.8 3 0 0 3 3 3 0 Intracellular hyaluronan-binding protein 4 N-terminal T2SSE PF00437.20 EFX01197.1 - 0.034 13.2 0.0 0.089 11.8 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein DND1_DSRM PF14709.7 EFX01197.1 - 0.074 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 ATPase PF06745.13 EFX01197.1 - 0.11 11.9 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 KaiC CSN8_PSD8_EIF3K PF10075.9 EFX01198.1 - 3.5e-41 140.5 0.0 4.8e-41 140.1 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Polyketide_cyc2 PF10604.9 EFX01199.1 - 0.012 15.9 0.3 0.028 14.7 0.3 1.6 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Arm-DNA-bind_3 PF13356.6 EFX01199.1 - 0.11 12.9 0.5 5.2 7.5 0.0 2.5 2 0 0 2 2 2 0 Arm DNA-binding domain KAR9 PF08580.10 EFX01199.1 - 6.5 5.2 9.6 8.5 4.8 9.6 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Peptidase_C78 PF07910.13 EFX01200.1 - 1.1e-62 211.2 0.0 1.6e-62 210.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 BaffR-Tall_bind PF09256.10 EFX01202.1 - 0.17 11.6 0.5 0.17 11.6 0.5 2.2 2 0 0 2 2 2 0 BAFF-R, TALL-1 binding Ion_trans PF00520.31 EFX01203.1 - 8.3e-112 372.3 86.3 4.2e-37 127.7 6.8 4.8 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 EFX01203.1 - 0.0055 16.2 0.0 0.016 14.8 0.0 1.9 1 0 0 1 1 1 1 EF hand GPHH PF16905.5 EFX01203.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated Glyco_hydro_47 PF01532.20 EFX01204.1 - 8.1e-145 483.2 0.0 2.5e-144 481.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 SAP PF02037.27 EFX01205.1 - 2.5e-14 52.6 0.1 4.1e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 EFX01205.1 - 0.0016 18.2 1.8 0.0016 18.2 1.8 2.5 2 1 0 2 2 2 1 Tho1/MOS11 C-terminal domain TMEM108 PF15759.5 EFX01205.1 - 0.004 16.2 2.5 0.006 15.7 2.5 1.3 1 0 0 1 1 1 1 TMEM108 family HeH PF12949.7 EFX01205.1 - 0.013 15.2 0.1 0.027 14.2 0.1 1.5 1 0 0 1 1 1 0 HeH/LEM domain Spt4 PF06093.13 EFX01206.1 - 6.3e-32 109.5 0.1 7.8e-32 109.2 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 EFX01206.1 - 0.04 13.9 0.3 0.13 12.3 0.1 1.8 1 1 1 2 2 2 0 Coronavirus gene 5 protein Fungal_trans PF04082.18 EFX01207.1 - 1.4e-20 73.4 0.1 6.5e-20 71.3 0.1 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01207.1 - 0.00047 20.2 5.6 0.00074 19.6 5.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PEMT PF04191.13 EFX01209.1 - 8e-31 106.6 5.0 1.5e-30 105.7 2.6 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase Ceramidase PF05875.12 EFX01210.1 - 6e-97 324.2 16.6 6.9e-97 324.0 16.6 1.0 1 0 0 1 1 1 1 Ceramidase TMEM191C PF15194.6 EFX01210.1 - 0.15 12.2 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 TMEM191C family Mod_r PF07200.13 EFX01211.1 - 1.7e-34 119.0 0.0 2.1e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Phage_TAC_10 PF10963.8 EFX01211.1 - 0.2 11.8 0.0 0.39 10.9 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone Mob1_phocein PF03637.17 EFX01212.1 - 4.6e-41 140.7 0.2 6.5e-41 140.2 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family bZIP_2 PF07716.15 EFX01213.1 - 0.012 15.6 10.2 0.012 15.6 10.2 2.4 3 0 0 3 3 3 0 Basic region leucine zipper DUF188 PF02639.14 EFX01213.1 - 5.9 6.6 7.5 19 4.9 3.6 2.4 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Med11 PF10280.9 EFX01215.1 - 3.5e-46 157.1 0.1 4.2e-46 156.8 0.1 1.1 1 0 0 1 1 1 1 Mediator complex protein Glyoxalase PF00903.25 EFX01216.1 - 7.6e-40 136.1 0.2 3e-19 69.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFX01216.1 - 1.1e-14 54.5 0.0 2e-06 28.0 0.0 3.6 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EFX01216.1 - 2.3e-06 28.3 0.0 0.084 13.7 0.0 3.0 2 2 1 3 3 3 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EFX01216.1 - 3.9e-05 23.6 2.0 1.3 9.0 0.0 4.4 4 1 1 5 5 5 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EFX01216.1 - 5.3e-05 23.4 0.0 0.49 10.5 0.0 3.6 1 1 0 2 2 2 2 Glyoxalase-like domain MoaF PF10703.9 EFX01216.1 - 0.003 17.5 0.1 0.16 11.9 0.0 2.6 2 0 0 2 2 2 1 MoaF N-terminal domain CppA_N PF14506.6 EFX01216.1 - 0.066 13.3 0.0 3.6 7.7 0.0 2.3 2 0 0 2 2 2 0 CppA N-terminal Cas_GSU0053 PF09617.10 EFX01216.1 - 0.15 12.0 0.0 0.78 9.7 0.0 1.9 2 0 0 2 2 2 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) MMgT PF10270.9 EFX01218.1 - 4e-35 120.1 0.0 4.8e-35 119.9 0.0 1.0 1 0 0 1 1 1 1 Membrane magnesium transporter H_PPase PF03030.16 EFX01218.1 - 0.18 10.4 0.0 0.2 10.2 0.0 1.0 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase Atg14 PF10186.9 EFX01222.1 - 8.4e-09 34.9 2.4 5.4e-07 29.0 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EFX01222.1 - 8.8e-05 21.6 0.0 1 8.1 0.0 3.5 3 1 0 3 3 3 3 Vacuolar protein sorting 38 APG6 PF04111.12 EFX01222.1 - 0.0033 17.4 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain Snapin_Pallidin PF14712.6 EFX01222.1 - 0.014 15.8 0.5 0.047 14.1 0.1 2.0 2 0 0 2 2 2 0 Snapin/Pallidin BON PF04972.17 EFX01222.1 - 0.05 13.9 0.0 0.18 12.1 0.0 1.9 1 0 0 1 1 1 0 BON domain GTP_EFTU PF00009.27 EFX01223.1 - 1.2e-43 148.9 0.0 2e-43 148.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EFX01223.1 - 7.4e-19 67.8 1.6 1.4e-18 67.0 1.6 1.4 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 EFX01223.1 - 2.7e-08 34.1 0.0 7.7e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFX01223.1 - 2.3e-07 30.9 0.0 3.4e-05 23.9 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFX01223.1 - 2.7e-07 30.9 0.6 1.6e-06 28.4 0.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Roc PF08477.13 EFX01223.1 - 0.057 13.6 0.0 5 7.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PGA2 PF07543.12 EFX01224.1 - 4.5e-48 162.7 0.2 5.2e-48 162.5 0.2 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 YedD PF13987.6 EFX01224.1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.3 1 0 0 1 1 1 1 YedD-like protein DUF945 PF06097.11 EFX01224.1 - 0.017 14.2 3.2 0.02 14.0 3.2 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) REV PF00424.18 EFX01224.1 - 0.047 13.7 0.4 0.11 12.6 0.1 1.7 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) IGF2_C PF08365.11 EFX01224.1 - 0.9 9.6 4.5 16 5.6 0.8 2.2 2 0 0 2 2 2 0 Insulin-like growth factor II E-peptide PhyH PF05721.13 EFX01225.1 - 6.9e-51 173.5 0.0 8.9e-51 173.1 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Med5 PF08689.10 EFX01226.1 - 3e-90 303.5 0.0 8.3e-89 298.8 0.0 2.3 1 1 0 1 1 1 1 Mediator complex subunit Med5 MOR2-PAG1_C PF14225.6 EFX01226.1 - 0.00041 20.3 0.5 0.00086 19.2 0.1 1.6 2 0 0 2 2 2 1 Cell morphogenesis C-terminal SIP1 PF04938.12 EFX01226.1 - 0.013 15.2 0.5 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) Mito_carr PF00153.27 EFX01228.1 - 3e-72 238.6 0.0 2.6e-25 88.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EFX01228.1 - 1.1e-14 54.6 2.3 2.1e-07 31.3 0.1 3.7 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 EFX01228.1 - 2.2e-11 42.5 0.0 1.9e-06 27.0 0.0 4.2 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 EFX01228.1 - 3.6e-11 42.0 1.0 1e-05 25.0 0.0 4.8 5 0 0 5 5 5 2 EF-hand domain EF-hand_8 PF13833.6 EFX01228.1 - 2.7e-08 33.6 0.1 0.15 12.0 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFX01228.1 - 1.1e-06 27.9 1.8 6.3e-06 25.4 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 EFX01228.1 - 0.097 13.0 0.0 1.5 9.2 0.0 2.9 4 0 0 4 4 4 0 EF-hand domain WD40 PF00400.32 EFX01229.1 - 3.4e-14 53.0 7.7 0.0021 18.8 0.0 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01229.1 - 5.1e-06 26.7 0.0 0.2 12.0 0.0 4.3 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3022 PF11226.8 EFX01229.1 - 0.072 13.6 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3022) PD40 PF07676.12 EFX01229.1 - 0.13 12.3 0.0 9.3 6.3 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Es2 PF09751.9 EFX01230.1 - 1.2e-130 437.2 1.3 2.5e-130 436.1 1.3 1.6 1 0 0 1 1 1 1 Nuclear protein Es2 ABC1 PF03109.16 EFX01230.1 - 7.5e-30 103.5 0.0 1.5e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 ABC1 family ADH_zinc_N PF00107.26 EFX01231.1 - 0.00022 21.2 0.2 0.00038 20.4 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX01231.1 - 0.00025 20.9 0.0 0.0007 19.5 0.0 1.7 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_4 PF08386.10 EFX01232.1 - 8.8e-20 70.7 0.0 1.5e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 EFX01232.1 - 1.7e-18 67.2 0.2 1.3e-15 57.7 0.2 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold NDT80_PhoG PF05224.12 EFX01233.1 - 6.1e-33 114.6 0.0 6.1e-33 114.6 0.0 2.3 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family PAT1 PF09770.9 EFX01233.1 - 1.1 7.4 25.9 1.8 6.7 25.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 EFX01233.1 - 1.3 7.5 17.9 0.67 8.4 7.4 2.1 2 0 0 2 2 2 0 Macoilin family AXIN1_TNKS_BD PF16646.5 EFX01233.1 - 4.2 8.4 8.2 0.46 11.5 2.2 2.5 2 0 0 2 2 2 0 Axin-1 tankyrase binding domain Ndufs5 PF10200.9 EFX01235.1 - 0.0013 18.9 0.0 0.0017 18.5 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.8 EFX01235.1 - 0.007 16.7 0.6 0.02 15.3 0.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3128) COX17 PF05051.13 EFX01235.1 - 0.023 15.0 0.3 0.038 14.4 0.3 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 EFX01235.1 - 0.048 13.8 0.1 0.099 12.8 0.1 1.5 1 1 0 1 1 1 0 CHCH domain COX6B PF02297.17 EFX01235.1 - 0.053 13.8 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Nramp PF01566.18 EFX01236.1 - 1.9e-83 280.4 23.1 1.6e-50 172.1 10.0 2.4 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein Glyco_hydro_7 PF00840.20 EFX01237.1 - 1.1e-131 439.5 2.5 2.5e-69 234.1 0.3 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 7 FA_desaturase PF00487.24 EFX01239.1 - 1.2e-28 100.6 26.3 1.7e-28 100.1 26.3 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFX01239.1 - 7.8e-09 35.6 0.0 1.6e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ERG4_ERG24 PF01222.17 EFX01240.1 - 8.6e-137 456.4 17.0 1.1e-136 456.1 17.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family NPP1 PF05630.11 EFX01241.1 - 5.1e-62 209.5 0.0 5.8e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) PQ-loop PF04193.14 EFX01242.1 - 5.8e-10 38.8 0.2 2.9e-05 23.7 0.0 2.6 2 0 0 2 2 2 2 PQ loop repeat Strabismus PF06638.11 EFX01242.1 - 2.1 6.9 4.7 1.3 7.6 2.3 1.7 2 0 0 2 2 2 0 Strabismus protein Ank_2 PF12796.7 EFX01243.1 - 8.7e-53 176.9 5.3 1.2e-17 64.3 0.2 4.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01243.1 - 1.2e-43 147.0 0.3 2.6e-09 37.4 0.0 5.9 3 2 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01243.1 - 6.9e-42 136.6 0.4 0.0002 21.6 0.0 9.4 9 0 0 9 9 9 7 Ankyrin repeat Ank PF00023.30 EFX01243.1 - 3.7e-39 131.5 7.4 7.7e-05 23.0 0.0 9.1 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 EFX01243.1 - 2e-30 104.4 6.4 5.3e-06 26.6 0.2 7.2 1 1 6 7 7 7 7 Ankyrin repeats (many copies) DUF676 PF05057.14 EFX01243.1 - 0.00019 21.0 0.1 0.00046 19.8 0.0 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EFX01243.1 - 0.0033 18.1 0.1 0.0079 16.8 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1834 PF08873.11 EFX01243.1 - 0.032 14.0 0.0 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1834) Cutinase PF01083.22 EFX01243.1 - 0.082 12.9 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Cutinase Metallophos PF00149.28 EFX01244.1 - 1.2e-12 48.8 0.0 5.1e-12 46.7 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFX01244.1 - 1.9e-06 28.2 0.1 0.0011 19.2 0.0 2.4 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EFX01244.1 - 0.078 12.3 0.0 0.29 10.4 0.0 1.7 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Thioredoxin PF00085.20 EFX01245.1 - 2.4e-23 82.0 0.0 2.9e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EFX01245.1 - 5.6e-06 25.9 0.0 6.3e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFX01245.1 - 2e-05 25.0 0.2 0.00019 21.8 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFX01245.1 - 3.8e-05 23.9 0.0 0.00025 21.3 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 EFX01245.1 - 0.0036 17.2 0.0 0.008 16.1 0.0 1.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 EFX01245.1 - 0.049 13.4 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.21 EFX01245.1 - 0.1 12.5 0.2 1.4 8.9 0.0 1.9 1 1 1 2 2 2 0 AhpC/TSA family Pox_MCEL PF03291.16 EFX01246.1 - 1.4e-69 234.8 0.0 2.3e-47 161.7 0.0 2.5 1 1 0 2 2 2 2 mRNA capping enzyme Methyltransf_25 PF13649.6 EFX01246.1 - 8.1e-11 42.5 0.1 0.00015 22.4 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01246.1 - 3.8e-08 34.0 0.3 0.0047 17.6 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01246.1 - 2.6e-06 27.3 0.1 0.0015 18.4 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01246.1 - 4.4e-06 27.2 0.1 0.17 12.6 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EFX01246.1 - 0.00025 20.9 0.0 0.00057 19.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EFX01246.1 - 0.0003 20.1 0.0 0.00052 19.3 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Raftlin PF15250.6 EFX01246.1 - 0.12 11.1 2.4 0.14 10.9 0.0 1.9 2 0 0 2 2 2 0 Raftlin G-alpha PF00503.20 EFX01247.1 - 1.3e-109 366.7 0.0 1.5e-109 366.4 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFX01247.1 - 1.3e-12 47.5 1.4 7.3e-08 32.1 0.1 2.6 2 2 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFX01247.1 - 0.00022 20.7 0.1 0.042 13.2 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFX01247.1 - 0.049 13.9 0.1 5.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EFX01247.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family GTP_EFTU PF00009.27 EFX01247.1 - 0.15 11.6 0.0 0.94 9.0 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DOPA_dioxygen PF08883.11 EFX01248.1 - 9.5e-41 138.3 0.0 1.5e-40 137.7 0.0 1.3 1 1 0 1 1 1 1 Dopa 4,5-dioxygenase family Lactamase_B PF00753.27 EFX01249.1 - 7.3e-16 58.8 2.7 1.1e-15 58.2 2.7 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFX01249.1 - 0.0014 18.2 0.3 0.0025 17.3 0.3 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Spermine_synth PF01564.17 EFX01250.1 - 4e-73 244.8 0.0 6.4e-73 244.2 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EFX01250.1 - 5.6e-26 90.2 0.1 9.3e-26 89.5 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EFX01250.1 - 6.7e-05 23.5 0.0 0.00013 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01250.1 - 0.0035 18.1 0.2 0.011 16.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EFX01250.1 - 0.025 13.8 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_2 PF00891.18 EFX01250.1 - 0.045 13.0 0.3 0.18 11.1 0.1 1.9 1 1 1 2 2 2 0 O-methyltransferase domain MTS PF05175.14 EFX01250.1 - 0.17 11.4 0.0 0.4 10.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain HECT PF00632.25 EFX01251.1 - 1.3e-65 221.9 0.0 2.2e-65 221.1 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EFX01251.1 - 9.9e-20 70.5 3.9 2.2e-19 69.4 3.9 1.6 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Cation_ATPase_C PF00689.21 EFX01252.1 - 1.4e-23 83.5 8.7 1.4e-23 83.5 8.7 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFX01252.1 - 4.5e-22 79.4 0.1 7.3e-09 36.2 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFX01252.1 - 5.8e-21 74.8 13.0 9.3e-13 48.1 0.0 3.9 3 1 1 4 4 4 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 EFX01252.1 - 8.1e-13 47.9 0.0 1.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFX01252.1 - 3.9e-12 46.1 0.0 6.9e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFX01252.1 - 2.2e-05 24.3 0.5 3.5e-05 23.7 0.5 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 EFX01252.1 - 0.0059 16.4 0.3 0.0059 16.4 0.3 3.0 3 0 0 3 3 3 1 Predicted membrane protein (DUF2157) HAD PF12710.7 EFX01252.1 - 0.01 16.2 0.0 0.056 13.8 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF202 PF02656.15 EFX01252.1 - 4.4 7.8 13.3 1.3 9.5 0.7 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Metallophos PF00149.28 EFX01253.1 - 9.8e-32 111.1 0.0 1.5e-31 110.5 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EFX01253.1 - 1e-31 109.1 0.1 4.9e-31 106.9 0.0 2.1 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 EFX01253.1 - 1.5e-09 37.3 8.4 9.8e-05 22.0 0.3 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFX01253.1 - 1.5e-09 37.4 6.0 6.1e-06 25.8 0.6 2.7 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 EFX01253.1 - 1.6e-09 37.1 4.5 0.005 16.9 0.4 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFX01253.1 - 2.2e-05 24.5 1.1 0.056 13.9 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX01253.1 - 0.0029 17.7 0.6 0.043 14.0 0.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFX01253.1 - 0.007 16.5 0.1 0.37 11.0 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01253.1 - 0.026 15.2 3.2 0.89 10.3 0.1 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFX01253.1 - 0.042 14.4 2.2 9.8 6.8 1.3 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat Amidase PF01425.21 EFX01254.1 - 1.4e-73 248.4 4.0 4e-73 246.9 4.0 1.7 1 1 0 1 1 1 1 Amidase tRNA-synt_1 PF00133.22 EFX01255.1 - 1.6e-34 119.1 0.0 1.5e-23 82.9 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFX01255.1 - 2.7e-15 56.0 0.0 2.2e-08 33.3 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFX01255.1 - 7.1e-15 55.3 0.1 2e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFX01255.1 - 2.4e-06 27.1 0.0 4.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Prefoldin PF02996.17 EFX01256.1 - 6.1e-23 81.0 0.0 7.9e-23 80.7 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EFX01256.1 - 0.023 14.7 0.2 4.3 7.4 0.0 2.1 2 0 0 2 2 2 0 Prefoldin subunit Cep57_MT_bd PF06657.13 EFX01256.1 - 0.029 14.8 0.1 0.065 13.7 0.1 1.5 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF1664 PF07889.12 EFX01256.1 - 0.057 13.5 0.3 0.69 10.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DASH_Dam1 PF08653.10 EFX01256.1 - 0.14 12.0 0.1 5.6 6.8 0.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 CAP_N PF01213.19 EFX01256.1 - 0.15 11.5 0.1 11 5.4 0.0 2.0 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Ribosomal_S14 PF00253.21 EFX01257.1 - 1e-14 54.0 2.9 1e-14 54.0 2.9 2.1 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Peptidase_M28 PF04389.17 EFX01258.1 - 1.7e-35 122.5 0.0 2.8e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFX01258.1 - 0.0029 17.3 0.0 0.0053 16.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 MOSC PF03473.17 EFX01259.1 - 2.6e-32 111.6 0.0 4.2e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EFX01259.1 - 4e-10 39.6 0.0 7e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain SNF2_N PF00176.23 EFX01261.1 - 2e-42 145.2 0.0 2.5e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain EIN3 PF04873.13 EFX01261.1 - 0.0049 16.2 0.0 0.0081 15.5 0.0 1.2 1 0 0 1 1 1 1 Ethylene insensitive 3 Fibrillarin PF01269.17 EFX01262.1 - 1.3e-101 338.5 0.0 1.5e-101 338.3 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EFX01262.1 - 1.1e-05 25.3 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 EFX01262.1 - 0.0088 16.7 0.0 0.013 16.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EFX01262.1 - 0.023 14.3 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EFX01262.1 - 0.033 14.3 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 EFX01262.1 - 0.047 13.4 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HisG PF01634.18 EFX01263.1 - 1.1e-53 181.5 0.1 2.2e-53 180.5 0.0 1.5 2 0 0 2 2 2 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EFX01263.1 - 7.1e-29 99.8 0.7 1.7e-28 98.6 0.2 1.9 2 0 0 2 2 2 1 HisG, C-terminal domain ATP-synt_D PF01813.17 EFX01264.1 - 0.016 15.1 4.8 0.016 15.1 2.4 1.9 2 0 0 2 2 2 0 ATP synthase subunit D LOH1CR12 PF10158.9 EFX01264.1 - 0.017 15.1 3.8 0.048 13.7 2.7 2.0 1 1 1 2 2 2 0 Tumour suppressor protein CENP-H PF05837.12 EFX01264.1 - 0.38 11.2 10.4 1.6 9.2 2.7 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 EFX01264.1 - 1.2 9.2 4.8 0.46 10.5 1.9 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1515 PF07439.11 EFX01264.1 - 2.7 8.0 3.9 1.9 8.5 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) KLRAQ PF10205.9 EFX01264.1 - 3 8.1 8.7 19 5.6 3.6 2.7 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF4164 PF13747.6 EFX01264.1 - 5.7 7.3 19.2 5 7.5 1.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF4763 PF15960.5 EFX01264.1 - 8 5.7 14.2 14 4.8 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Fungal_trans_2 PF11951.8 EFX01265.1 - 0.053 12.3 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF4081 PF13312.6 EFX01265.1 - 0.088 13.0 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) Zn_clus PF00172.18 EFX01266.1 - 0.0026 17.8 7.2 0.0053 16.9 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.14 EFX01266.1 - 2.2 7.6 13.3 3.7 6.9 13.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AAA_16 PF13191.6 EFX01267.1 - 5.1e-11 43.2 1.6 6.9e-08 33.1 0.0 2.9 1 1 1 2 2 2 2 AAA ATPase domain NB-ARC PF00931.22 EFX01267.1 - 1.4e-08 34.3 0.0 2.7e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EFX01267.1 - 3.9e-06 27.2 0.0 2.7e-05 24.5 0.0 2.3 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EFX01267.1 - 0.00045 20.2 0.0 0.00077 19.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DUF676 PF05057.14 EFX01267.1 - 0.0015 18.1 0.0 0.0032 17.0 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) ATPase_2 PF01637.18 EFX01267.1 - 0.0073 16.2 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFX01267.1 - 0.028 14.1 0.0 0.066 12.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Abhydrolase_6 PF12697.7 EFX01267.1 - 0.034 14.7 0.2 0.093 13.3 0.0 1.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EFX01267.1 - 0.058 13.1 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 PGAP1-like protein SRP54 PF00448.22 EFX01267.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Peptidase_M22 PF00814.25 EFX01268.1 - 3.8e-81 272.8 0.0 4.6e-81 272.5 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family G-patch PF01585.23 EFX01269.1 - 3.9e-08 33.1 2.5 6.9e-08 32.3 2.5 1.4 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EFX01269.1 - 0.00038 20.2 0.0 0.00063 19.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AIM3 PF17096.5 EFX01269.1 - 0.063 14.2 1.3 0.063 14.2 1.3 4.5 5 1 0 5 5 5 0 Altered inheritance of mitochondria protein 3 Cactin_mid PF10312.9 EFX01270.1 - 1.8e-59 200.8 1.0 2.6e-59 200.3 1.0 1.2 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EFX01270.1 - 3.2e-57 191.9 2.7 5.2e-57 191.2 2.7 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DUF1087 PF06465.13 EFX01270.1 - 0.065 13.3 0.7 0.54 10.3 0.2 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) TMEM151 PF14857.6 EFX01271.1 - 4.1 6.2 5.0 0.36 9.7 0.4 1.5 2 0 0 2 2 2 0 TMEM151 family 7tm_2 PF00002.24 EFX01272.1 - 1.7e-13 50.4 6.0 8.1e-13 48.2 3.8 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EFX01272.1 - 1.2e-11 44.3 6.9 1.2e-11 44.3 6.9 1.7 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 EFX01272.1 - 5.4e-11 42.3 2.9 6.9e-11 42.0 2.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 EFX01272.1 - 4.6e-08 33.1 7.8 1e-07 32.0 7.8 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 EFX01272.1 - 4.6e-06 26.2 2.0 8.3e-06 25.4 2.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glyoxalase_6 PF18029.1 EFX01272.1 - 0.0078 17.0 0.9 0.017 15.9 0.9 1.7 1 1 0 1 1 1 1 Glyoxalase-like domain Oxidored_q5_N PF01059.17 EFX01272.1 - 0.14 12.2 0.2 0.14 12.2 0.2 2.6 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus TMEMspv1-c74-12 PF11044.8 EFX01272.1 - 0.2 11.6 0.2 0.57 10.2 0.2 1.7 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein P53_C PF11619.8 EFX01272.1 - 0.22 11.6 0.1 0.46 10.6 0.1 1.5 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain Bd3614-deam PF14439.6 EFX01272.1 - 1.9 8.6 4.9 3.5 7.7 4.2 1.8 1 1 0 1 1 1 0 Bd3614-like deaminase MFS_1 PF07690.16 EFX01273.1 - 8.9e-14 51.2 32.2 2.4e-07 30.0 25.3 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily SpoVAB PF13782.6 EFX01273.1 - 6.1 7.2 11.1 4.7 7.6 0.9 3.4 3 1 0 3 3 3 0 Stage V sporulation protein AB IF4E PF01652.18 EFX01274.1 - 1e-49 168.4 0.0 1.3e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Amidohydro_1 PF01979.20 EFX01275.1 - 5.6e-12 45.6 0.0 5.7e-11 42.3 0.0 2.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX01275.1 - 1.5e-11 44.4 0.4 9.4e-08 31.9 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family DUF5304 PF17230.2 EFX01275.1 - 0.17 12.1 0.0 0.31 11.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5304) Fungal_trans_2 PF11951.8 EFX01276.1 - 1.2e-08 34.2 0.1 2e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01276.1 - 8.4e-08 32.2 10.9 1.3e-07 31.6 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_25 PF13649.6 EFX01277.1 - 0.12 13.1 0.0 0.68 10.7 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01277.1 - 0.21 12.3 0.0 0.68 10.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Cellulase PF00150.18 EFX01279.1 - 2.3e-13 50.2 1.0 5e-13 49.1 1.0 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ETRAMP PF09716.10 EFX01279.1 - 0.026 14.6 0.0 0.052 13.6 0.0 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3632 PF12311.8 EFX01281.1 - 4.3e-10 40.3 1.4 5.3e-10 40.0 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Acetyltransf_1 PF00583.25 EFX01282.1 - 5.1e-06 26.7 0.0 5.3e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX01282.1 - 0.0013 19.1 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFX01282.1 - 0.0021 18.1 1.1 1.5 8.9 0.2 3.5 2 2 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFX01282.1 - 0.0084 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX01282.1 - 0.021 14.8 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein YCII PF03795.14 EFX01283.1 - 8.7e-07 29.3 0.0 1.2e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain adh_short_C2 PF13561.6 EFX01284.1 - 8.1e-61 205.6 0.8 1.1e-60 205.2 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01284.1 - 3.3e-50 170.3 1.3 4.6e-50 169.8 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01284.1 - 4.6e-11 42.9 0.4 7.5e-11 42.3 0.4 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX01284.1 - 0.00014 21.4 0.3 0.00024 20.6 0.3 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFX01284.1 - 0.0024 17.1 0.0 0.0037 16.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFX01284.1 - 0.0026 17.2 0.3 0.0057 16.1 0.3 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase PA PF02225.22 EFX01284.1 - 0.0043 17.1 0.8 0.059 13.4 0.2 2.5 2 1 0 2 2 2 1 PA domain Gly_rich_SFCGS PF14272.6 EFX01284.1 - 0.12 12.4 0.6 0.25 11.3 0.6 1.6 1 0 0 1 1 1 0 Glycine-rich SFCGS L_HMGIC_fpl PF10242.9 EFX01286.1 - 0.00022 21.5 0.6 0.00022 21.5 0.6 1.7 2 0 0 2 2 2 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.6 EFX01286.1 - 0.0062 16.3 9.1 0.055 13.2 9.1 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction MARVEL PF01284.23 EFX01286.1 - 0.088 12.8 13.0 0.11 12.5 7.3 2.6 2 1 0 2 2 2 0 Membrane-associating domain GCP_N_terminal PF17681.1 EFX01287.1 - 7.5e-34 117.7 0.0 1.5e-33 116.8 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFX01287.1 - 5.9e-30 104.8 0.1 2.2e-29 102.9 0.0 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EFX01287.1 - 0.024 13.0 0.0 0.052 11.9 0.0 1.5 1 1 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 MPP6 PF10175.9 EFX01287.1 - 1.5 9.4 8.5 0.042 14.3 1.0 2.2 3 0 0 3 3 3 0 M-phase phosphoprotein 6 p450 PF00067.22 EFX01288.1 - 3.2e-40 138.3 0.0 6.7e-40 137.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 tRNA-synt_2b PF00587.25 EFX01289.1 - 2.7e-30 105.6 0.0 5.4e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFX01289.1 - 8.1e-19 67.9 7.6 8.1e-19 67.9 7.6 2.5 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain TetR_C_23 PF17931.1 EFX01289.1 - 0.11 12.6 1.7 3.1 8.0 0.7 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF817 PF05675.12 EFX01291.1 - 0.032 13.9 0.0 0.097 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF817) ANTH PF07651.16 EFX01291.1 - 0.069 12.1 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 ANTH domain ICE2 PF08426.10 EFX01292.1 - 1.2e-158 528.5 5.8 1.4e-158 528.3 5.8 1.0 1 0 0 1 1 1 1 ICE2 Peptidase_M14 PF00246.24 EFX01293.1 - 1.2e-68 232.0 0.0 1.5e-68 231.7 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase PTP_tm PF18861.1 EFX01294.1 - 0.0014 18.7 0.2 0.0027 17.7 0.2 1.4 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J SKG6 PF08693.10 EFX01294.1 - 0.0079 15.6 0.1 0.0079 15.6 0.1 2.1 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF2207 PF09972.9 EFX01294.1 - 0.027 13.2 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5305 PF17231.2 EFX01294.1 - 0.1 12.0 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) PsbJ PF01788.17 EFX01294.1 - 0.2 11.5 2.9 0.47 10.4 2.9 1.5 1 0 0 1 1 1 0 PsbJ Yip1 PF04893.17 EFX01294.1 - 0.25 11.0 2.5 0.4 10.4 0.3 2.0 2 0 0 2 2 2 0 Yip1 domain TrbC PF04956.13 EFX01294.1 - 0.41 10.9 4.8 0.34 11.1 0.8 2.4 2 0 0 2 2 2 0 TrbC/VIRB2 family Gly-zipper_Omp PF13488.6 EFX01294.1 - 1.1 9.3 17.9 3.1 7.9 6.5 2.5 2 0 0 2 2 2 0 Glycine zipper Macoilin PF09726.9 EFX01294.1 - 2.9 6.3 6.4 4 5.9 6.4 1.1 1 0 0 1 1 1 0 Macoilin family ATP-synt_C PF00137.21 EFX01295.1 - 1.7e-34 117.9 34.5 5.1e-22 78.0 15.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Tetraspanin PF00335.20 EFX01295.1 - 6 6.5 7.2 10 5.7 7.2 1.3 1 0 0 1 1 1 0 Tetraspanin family ECH_1 PF00378.20 EFX01296.1 - 1.1e-36 126.4 0.2 5.5e-29 101.2 0.0 3.1 2 1 0 3 3 3 3 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFX01296.1 - 2e-26 93.3 0.1 2.9e-22 79.6 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase SNF2_N PF00176.23 EFX01297.1 - 1.2e-49 169.0 0.0 2.3e-49 168.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EFX01297.1 - 3.5e-24 84.7 0.5 1.6e-23 82.5 0.5 2.2 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EFX01297.1 - 3.3e-19 69.3 0.0 1.1e-18 67.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX01297.1 - 3.4e-07 30.4 0.0 2e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFX01297.1 - 4.7e-07 29.3 0.0 1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_34 PF13872.6 EFX01297.1 - 0.54 9.1 2.6 1.9 7.3 0.2 2.4 3 0 0 3 3 3 0 P-loop containing NTP hydrolase pore-1 NYN PF01936.18 EFX01298.1 - 0.0013 19.2 0.0 0.019 15.5 0.0 2.3 1 1 0 1 1 1 1 NYN domain Complex1_30kDa PF00329.19 EFX01299.1 - 5.1e-45 153.0 0.0 7e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.9 EFX01299.1 - 0.16 12.2 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) CoA_transf_3 PF02515.17 EFX01300.1 - 2.1e-63 214.7 0.0 2.9e-63 214.2 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III PIG-Y PF15159.6 EFX01300.1 - 9.4e-18 64.9 9.5 2.1e-17 63.8 9.5 1.6 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.12 EFX01300.1 - 0.25 11.9 3.2 4.6 7.8 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) DrrA_P4M PF14860.6 EFX01301.1 - 0.026 14.4 0.9 0.28 11.0 0.0 2.3 1 1 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Exonuc_VII_L PF02601.15 EFX01302.1 - 0.033 13.8 0.7 21 4.6 0.0 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit zf-C4H2 PF10146.9 EFX01302.1 - 0.073 13.4 2.3 0.15 12.4 2.3 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein DUF515 PF04415.12 EFX01302.1 - 0.075 11.4 0.3 0.12 10.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF4407 PF14362.6 EFX01302.1 - 0.076 12.4 2.5 0.18 11.1 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 EFX01302.1 - 0.21 12.0 11.4 0.15 12.5 4.8 2.6 3 0 0 3 3 3 0 Fez1 Fmp27_WPPW PF10359.9 EFX01302.1 - 0.24 10.2 6.2 0.045 12.6 2.5 1.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain FapA PF03961.13 EFX01302.1 - 0.75 8.3 2.5 1.5 7.4 2.5 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2203 PF09969.9 EFX01302.1 - 0.92 10.2 4.6 0.56 10.9 1.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) PilO PF04350.13 EFX01302.1 - 1.3 9.2 4.8 0.58 10.3 0.4 2.4 1 1 1 2 2 2 0 Pilus assembly protein, PilO Spc24 PF08286.11 EFX01302.1 - 2.2 8.6 8.9 1.8 8.8 1.9 3.2 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.20 EFX01302.1 - 2.7 8.0 11.5 1 9.3 1.5 2.9 2 1 1 3 3 3 0 Prefoldin subunit adh_short_C2 PF13561.6 EFX01303.1 - 2.2e-41 141.9 2.5 2.7e-41 141.7 2.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01303.1 - 2.4e-39 134.9 0.4 3.2e-39 134.4 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01303.1 - 1.3e-11 44.7 1.1 1.3e-11 44.7 1.1 1.6 1 1 0 2 2 2 1 KR domain Eno-Rase_NADH_b PF12242.8 EFX01303.1 - 0.00083 19.1 2.3 0.41 10.4 0.1 2.3 2 0 0 2 2 2 2 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Glyco_transf_8 PF01501.20 EFX01305.1 - 9.4e-27 94.2 0.3 6.3e-26 91.5 0.3 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EFX01305.1 - 0.011 15.1 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 0 Mannosyltransferase putative DUF294_C PF10335.9 EFX01305.1 - 0.11 12.2 0.1 2 8.2 0.1 2.2 1 1 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain Disaggr_repeat PF06848.11 EFX01305.1 - 0.19 11.4 0.6 0.35 10.5 0.6 1.3 1 0 0 1 1 1 0 Disaggregatase related repeat Fungal_trans PF04082.18 EFX01306.1 - 2.2e-24 85.9 0.1 3.2e-24 85.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01306.1 - 1.2e-07 31.7 11.9 2e-07 31.0 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cytochrom_B558a PF05038.13 EFX01307.1 - 0.97 9.0 6.0 0.15 11.6 0.3 2.4 3 0 0 3 3 3 0 Cytochrome Cytochrome b558 alpha-subunit IGR PF09597.10 EFX01308.1 - 3.4e-25 87.9 0.2 5.3e-25 87.3 0.2 1.3 1 0 0 1 1 1 1 IGR protein motif SAM_1 PF00536.30 EFX01308.1 - 0.14 12.6 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ank_2 PF12796.7 EFX01309.1 - 1.5e-58 195.4 14.8 2.3e-17 63.3 0.0 5.6 2 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01309.1 - 4.1e-53 177.1 6.1 1.7e-09 38.0 0.0 9.9 3 2 8 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX01309.1 - 1.1e-50 169.0 13.9 6.2e-11 42.3 0.1 9.0 3 3 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01309.1 - 8.4e-48 154.8 9.4 0.00035 20.8 0.0 12.7 12 0 0 12 12 12 10 Ankyrin repeat Ank PF00023.30 EFX01309.1 - 1.2e-46 155.2 13.3 1.8e-05 25.0 0.0 12.3 12 0 0 12 12 12 9 Ankyrin repeat NACHT PF05729.12 EFX01309.1 - 0.0024 17.8 0.0 0.0062 16.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NifQ PF04891.12 EFX01309.1 - 0.023 15.0 1.1 0.051 13.9 0.4 1.9 2 0 0 2 2 2 0 NifQ Lipase_3 PF01764.25 EFX01310.1 - 1.6e-26 92.8 0.0 2.5e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_8 PF06259.12 EFX01310.1 - 0.014 15.0 0.3 0.022 14.4 0.3 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_6 PF12697.7 EFX01310.1 - 0.015 15.9 0.0 0.016 15.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX01310.1 - 0.052 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PAC4 PF16093.5 EFX01311.1 - 9.3e-20 70.6 0.1 1.6e-19 69.9 0.1 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 POC3_POC4 PF10448.9 EFX01311.1 - 0.079 13.0 0.0 0.098 12.7 0.0 1.1 1 0 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 SurE PF01975.17 EFX01312.1 - 1e-51 175.5 0.0 1.6e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE TTL PF03133.15 EFX01312.1 - 2.2e-50 171.5 0.0 3.1e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Glyco_transf_4 PF13439.6 EFX01312.1 - 0.046 13.7 0.3 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase Family 4 DNA_pol_phi PF04931.13 EFX01312.1 - 0.055 11.6 0.6 0.077 11.1 0.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi Glyco_trans_4_4 PF13579.6 EFX01312.1 - 0.31 11.5 15.5 0.86 10.0 4.7 3.2 2 1 1 3 3 3 0 Glycosyl transferase 4-like domain GCIP PF13324.6 EFX01312.1 - 1.1 8.7 2.5 2 8.0 2.5 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 EFX01312.1 - 9.8 5.4 8.9 18 4.5 8.9 1.3 1 0 0 1 1 1 0 NOA36 protein Ribosomal_L7Ae PF01248.26 EFX01313.1 - 5.3e-15 54.9 5.8 7.6e-15 54.4 1.7 2.8 2 1 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Iwr1 PF08574.10 EFX01313.1 - 0.097 13.7 1.0 0.097 13.7 1.0 3.0 2 1 0 2 2 2 0 Transcription factor Iwr1 RNA_pol_3_Rpc31 PF11705.8 EFX01313.1 - 0.16 12.2 0.1 0.16 12.2 0.1 2.6 2 1 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Myosin_head PF00063.21 EFX01314.1 - 2.8e-257 855.3 0.4 4.3e-257 854.7 0.4 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 EFX01314.1 - 3.1e-26 91.6 2.6 3.1e-26 91.6 2.6 2.8 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 EFX01314.1 - 2e-12 45.7 32.1 4.7e-05 22.8 0.4 6.9 6 0 0 6 6 6 3 IQ calmodulin-binding motif AAA_22 PF13401.6 EFX01314.1 - 0.0018 18.5 1.8 0.004 17.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Baculo_PEP_C PF04513.12 EFX01314.1 - 0.0076 16.3 13.1 0.16 12.1 13.1 2.9 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_16 PF13191.6 EFX01314.1 - 0.014 15.8 0.3 0.11 12.8 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain FlaC_arch PF05377.11 EFX01314.1 - 0.026 14.9 0.2 0.026 14.9 0.2 4.3 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) GAS PF13851.6 EFX01314.1 - 0.058 12.7 36.4 0.023 14.1 28.1 3.1 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding HSF_DNA-bind PF00447.17 EFX01314.1 - 0.065 13.9 0.5 0.36 11.5 0.5 2.3 1 0 0 1 1 1 0 HSF-type DNA-binding DUF812 PF05667.11 EFX01314.1 - 0.072 12.0 27.0 0.0074 15.2 21.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF812) RNA_helicase PF00910.22 EFX01314.1 - 0.11 12.9 0.0 0.36 11.2 0.0 2.0 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EFX01314.1 - 0.19 12.2 5.4 1.3 9.5 0.0 3.0 2 0 0 2 2 2 0 ABC transporter Sec34 PF04136.15 EFX01314.1 - 0.57 10.0 13.1 0.2 11.5 7.4 2.6 1 1 1 2 2 2 0 Sec34-like family Myosin_N PF02736.19 EFX01314.1 - 0.72 9.7 5.0 0.14 12.0 1.0 1.9 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain HsbA PF12296.8 EFX01314.1 - 0.82 10.1 7.1 2.4 8.6 7.1 1.9 1 0 0 1 1 1 0 Hydrophobic surface binding protein A Phage_GP20 PF06810.11 EFX01314.1 - 1.2 8.9 22.7 0.043 13.6 7.2 2.8 1 1 1 2 2 2 0 Phage minor structural protein GP20 Dna2 PF08696.11 EFX01314.1 - 1.3 8.7 8.1 0.98 9.2 5.3 2.2 1 1 1 2 2 2 0 DNA replication factor Dna2 CENP-F_leu_zip PF10473.9 EFX01314.1 - 1.6 8.7 36.0 0.94 9.5 12.3 3.0 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 EFX01314.1 - 2.1 8.8 32.0 0.94 9.9 24.1 3.4 2 1 0 2 2 2 0 Fez1 AAA_13 PF13166.6 EFX01314.1 - 2.5 6.6 22.5 0.021 13.5 13.6 1.9 2 0 0 2 2 2 0 AAA domain CALCOCO1 PF07888.11 EFX01314.1 - 3.3 6.5 31.9 0.057 12.3 21.7 2.2 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DegQ PF08181.11 EFX01314.1 - 3.9 7.6 7.2 0.35 11.0 0.4 2.8 2 0 0 2 2 2 0 DegQ (SacQ) family Laminin_II PF06009.12 EFX01314.1 - 5.1 7.1 18.5 4.3 7.4 6.3 2.7 1 1 1 2 2 2 0 Laminin Domain II Spidroin_N PF16763.5 EFX01314.1 - 6.3 6.8 7.8 37 4.4 0.1 3.1 2 1 1 3 3 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term Macoilin PF09726.9 EFX01314.1 - 7 5.1 20.3 13 4.2 20.3 1.3 1 0 0 1 1 1 0 Macoilin family Spc7 PF08317.11 EFX01314.1 - 9.8 5.0 35.3 0.055 12.4 23.1 2.9 2 1 0 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 EFX01315.1 - 2.9e-07 30.5 4.3 4.8e-07 29.8 4.3 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFX01315.1 - 4.8e-06 26.6 5.5 7.6e-06 25.9 5.5 1.3 1 0 0 1 1 1 1 Basic region leucine zipper CDC45 PF02724.14 EFX01315.1 - 0.076 11.3 1.7 0.091 11.0 1.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Aminotran_1_2 PF00155.21 EFX01316.1 - 1.1e-08 34.6 0.0 5.4e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class I and II EPL1 PF10513.9 EFX01317.1 - 7.8e-23 81.6 1.5 7.8e-23 81.6 1.5 2.4 2 1 0 2 2 2 1 Enhancer of polycomb-like CD99L2 PF12301.8 EFX01317.1 - 0.066 13.5 0.4 0.14 12.4 0.4 1.6 1 0 0 1 1 1 0 CD99 antigen like protein 2 Acyl-CoA_dh_N PF02771.16 EFX01318.1 - 8.2e-26 90.9 0.7 1.7e-25 89.9 0.7 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFX01318.1 - 2.1e-23 83.2 2.5 3.6e-23 82.4 2.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFX01318.1 - 1.1e-16 60.8 0.0 3.9e-16 59.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFX01318.1 - 3.6e-06 27.3 4.5 6.5e-06 26.5 4.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DnaJ PF00226.31 EFX01319.1 - 7.1e-21 74.1 1.0 1.7e-20 72.9 1.0 1.7 1 0 0 1 1 1 1 DnaJ domain Zn_clus PF00172.18 EFX01320.1 - 3.6e-07 30.2 8.6 6.1e-07 29.5 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydantoinase_B PF02538.14 EFX01321.1 - 3.2e-214 712.1 2.5 4.8e-214 711.6 2.5 1.3 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EFX01321.1 - 4e-100 334.8 1.5 4.5e-100 334.7 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFX01321.1 - 9.4e-56 188.3 0.0 9.5e-54 181.8 0.0 2.6 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region SNF2_N PF00176.23 EFX01322.1 - 5.7e-38 130.5 0.3 6.1e-32 110.7 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX01322.1 - 6.5e-11 42.6 0.4 9.3e-10 38.8 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFX01322.1 - 8.1e-05 22.5 0.0 0.002 17.9 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EFX01322.1 - 0.0039 17.2 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFX01322.1 - 0.0057 15.6 0.1 0.029 13.3 0.1 2.0 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF3152 PF11350.8 EFX01322.1 - 0.015 15.0 0.0 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3152) AMPKBI PF04739.15 EFX01323.1 - 1.6e-24 85.9 0.8 1.6e-24 85.9 0.8 2.8 3 1 0 3 3 3 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EFX01323.1 - 2.9e-24 85.1 0.0 5.7e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase TFIIA PF03153.13 EFX01323.1 - 0.6 10.0 33.3 0.04 13.9 24.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 EFX01323.1 - 0.83 8.3 11.7 1.2 7.9 11.7 1.1 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 EFX01323.1 - 3.3 7.9 6.2 7.6 6.7 6.2 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Suf PF05843.14 EFX01323.1 - 4.8 7.1 16.4 11 5.9 16.4 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 EFX01323.1 - 7.4 3.6 13.9 11 3.0 13.9 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NAD_binding_1 PF00175.21 EFX01324.1 - 1.4e-06 28.9 0.0 0.0075 16.9 0.0 2.8 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFX01324.1 - 0.00015 21.9 0.0 0.0045 17.1 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain CHZ PF09649.10 EFX01326.1 - 0.0057 16.1 2.4 0.0073 15.7 0.1 2.5 2 0 0 2 2 2 1 Histone chaperone domain CHZ AAA PF00004.29 EFX01327.1 - 3.8e-16 59.7 0.0 8.6e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EFX01327.1 - 4e-11 42.9 0.1 8.7e-11 41.8 0.1 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_22 PF13401.6 EFX01327.1 - 4.5e-09 36.7 0.0 1.7e-08 34.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX01327.1 - 4.9e-09 36.8 0.5 5.9e-08 33.3 0.0 2.8 3 1 0 3 3 2 1 AAA ATPase domain BAH PF01426.18 EFX01327.1 - 7.6e-07 29.0 0.0 1.9e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 BAH domain AAA_19 PF13245.6 EFX01327.1 - 0.0021 18.4 0.0 0.0055 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX01327.1 - 0.0074 16.4 0.7 0.64 10.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 EFX01327.1 - 0.014 15.2 0.3 0.072 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFX01327.1 - 0.029 14.9 0.0 0.065 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ssDBP PF17878.1 EFX01327.1 - 0.031 14.5 0.0 0.089 13.0 0.0 1.7 1 0 0 1 1 1 0 Single-stranded DNA-binding protein AAA_28 PF13521.6 EFX01327.1 - 0.035 14.3 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFX01327.1 - 0.069 13.1 0.0 0.16 11.9 0.0 1.6 1 1 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 EFX01327.1 - 0.073 13.0 0.0 0.7 9.8 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EFX01327.1 - 0.092 12.0 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_32 PF13654.6 EFX01327.1 - 0.18 10.6 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Choline_kinase PF01633.20 EFX01328.1 - 6e-47 160.0 0.0 5.5e-46 156.8 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EFX01328.1 - 3.6e-09 36.9 3.1 3.6e-09 36.9 3.1 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFX01328.1 - 0.11 11.7 0.0 0.29 10.4 0.0 1.7 1 1 0 1 1 1 0 Ecdysteroid kinase DUF3439 PF11921.8 EFX01328.1 - 9.7 6.2 18.1 6.9 6.7 6.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) F-box PF00646.33 EFX01329.1 - 2.9e-07 30.2 0.9 5e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFX01329.1 - 0.00039 20.3 2.1 0.00046 20.0 0.1 2.3 3 0 0 3 3 3 1 F-box-like SUIM_assoc PF16619.5 EFX01329.1 - 0.059 13.4 6.7 0.14 12.2 6.7 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 EFX01330.1 - 1.5e-29 102.4 8.7 1.9e-29 102.1 8.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DHHA1 PF02272.19 EFX01330.1 - 0.073 13.5 3.3 0.1 13.0 3.3 1.3 1 1 0 1 1 1 0 DHHA1 domain DIOX_N PF14226.6 EFX01331.1 - 1.8e-26 93.2 0.0 2.9e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX01331.1 - 6.4e-22 77.9 0.0 1.4e-21 76.9 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily SRR1 PF07985.12 EFX01332.1 - 2.7e-06 27.3 0.1 6.4e-06 26.1 0.1 1.7 1 0 0 1 1 1 1 SRR1 Myb_DNA-binding PF00249.31 EFX01333.1 - 1.5e-17 63.5 0.8 5.6e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX01333.1 - 3.9e-13 49.4 4.3 6e-09 36.0 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.8 EFX01333.1 - 0.083 13.1 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) p450 PF00067.22 EFX01334.1 - 7e-57 193.2 0.0 8.9e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PC4 PF02229.16 EFX01334.1 - 0.1 12.3 0.1 0.79 9.4 0.0 2.5 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) TFIIE_alpha PF02002.17 EFX01335.1 - 4.1e-19 68.4 0.3 8.8e-19 67.3 0.3 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit zinc-ribbons_6 PF07191.12 EFX01335.1 - 0.13 12.3 0.3 0.25 11.4 0.3 1.4 1 0 0 1 1 1 0 zinc-ribbons RNA_pol_3_Rpc31 PF11705.8 EFX01335.1 - 0.96 9.6 12.9 0.21 11.8 5.3 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Glyco_hydro_64 PF16483.5 EFX01336.1 - 5.8e-131 437.1 0.0 6.5e-131 437.0 0.0 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase DNA_ligase_A_M PF01068.21 EFX01337.1 - 7.9e-48 162.8 0.0 1.7e-45 155.2 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFX01337.1 - 1.5e-31 110.1 0.0 4.1e-31 108.6 0.0 1.8 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFX01337.1 - 9.8e-18 64.6 0.1 6.5e-16 58.7 0.1 3.0 1 1 0 1 1 1 1 ATP dependent DNA ligase C terminal region SUIM_assoc PF16619.5 EFX01337.1 - 0.042 13.9 2.1 0.11 12.6 2.1 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 NOA36 PF06524.12 EFX01337.1 - 6.6 6.0 6.3 0.63 9.3 1.3 1.8 2 0 0 2 2 2 0 NOA36 protein CENP-B_dimeris PF09026.10 EFX01337.1 - 9.8 6.6 8.4 25 5.3 6.8 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Velvet PF11754.8 EFX01338.1 - 3e-42 145.3 5.1 8.3e-29 101.3 1.2 3.7 3 2 1 4 4 4 2 Velvet factor GATase_4 PF13230.6 EFX01339.1 - 1.5e-17 63.4 0.1 2e-15 56.5 0.1 2.2 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EFX01339.1 - 5.9e-09 36.2 0.0 1.1e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Ras PF00071.22 EFX01340.1 - 3.8e-44 150.1 0.0 4.3e-44 150.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX01340.1 - 1.2e-15 57.8 0.1 1.6e-15 57.4 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX01340.1 - 2.9e-07 30.1 0.0 3.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX01340.1 - 6.9e-05 22.9 0.0 8.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFX01340.1 - 0.0017 17.8 0.0 0.0031 17.0 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFX01340.1 - 0.0059 16.2 0.0 0.029 13.9 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFX01340.1 - 0.027 14.4 0.0 3.2 7.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_14 PF13173.6 EFX01340.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EFX01340.1 - 0.12 11.9 0.0 0.69 9.4 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B KCH PF16944.5 EFX01341.1 - 4.3e-97 324.8 15.0 5.4e-97 324.5 15.0 1.1 1 0 0 1 1 1 1 Fungal potassium channel TFIID_NTD2 PF04494.15 EFX01342.1 - 1.5e-39 135.2 0.0 2.2e-39 134.7 0.0 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 EFX01342.1 - 2.2e-36 123.2 19.9 3.6e-06 27.6 0.3 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01342.1 - 2e-11 44.0 0.6 0.055 13.8 0.0 5.4 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX01342.1 - 0.00023 21.1 0.2 0.015 15.2 0.0 3.2 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFX01342.1 - 0.00092 18.3 0.9 1.4 7.8 0.0 3.6 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH PF08513.11 EFX01342.1 - 0.0013 18.6 0.1 0.0038 17.1 0.1 1.8 1 0 0 1 1 1 1 LisH Nucleoporin_N PF08801.11 EFX01342.1 - 0.015 14.0 0.1 1.1 8.0 0.0 2.6 2 1 0 2 2 2 0 Nup133 N terminal like RAB3GAP2_N PF14655.6 EFX01342.1 - 0.082 12.2 0.0 11 5.2 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.8 EFX01342.1 - 0.88 8.1 3.6 8.3 4.9 0.1 3.1 3 1 1 4 4 4 0 Nucleoporin Nup120/160 Hexokinase_2 PF03727.16 EFX01343.1 - 4.8e-53 180.0 0.0 6.8e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EFX01343.1 - 3.3e-40 138.1 0.0 5.1e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase MAGE_N PF12440.8 EFX01343.1 - 1.2 9.9 11.9 2.6 8.8 11.9 1.6 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal HEAT_EZ PF13513.6 EFX01344.1 - 1.4e-32 111.7 26.9 8.3e-18 64.5 0.1 11.0 10 2 2 12 12 12 5 HEAT-like repeat HEAT PF02985.22 EFX01344.1 - 1.2e-24 84.2 11.1 7.6e-05 22.6 0.0 9.5 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 EFX01344.1 - 7.5e-20 71.1 6.8 6.4e-05 23.3 0.2 7.6 6 1 1 7 7 7 5 HEAT repeats Cnd1 PF12717.7 EFX01344.1 - 9.3e-09 35.5 0.0 0.07 13.2 0.0 4.4 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFX01344.1 - 1.5e-06 28.7 0.0 0.13 12.9 0.0 5.5 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 EFX01344.1 - 5.4e-06 26.2 0.0 0.00076 19.4 0.0 4.0 3 1 1 4 4 4 1 Importin-beta N-terminal domain MMS19_C PF12460.8 EFX01344.1 - 3.1e-05 23.3 0.1 0.39 9.8 0.2 3.8 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal Arm PF00514.23 EFX01344.1 - 0.00023 21.1 10.5 0.4 10.8 0.1 6.5 5 1 0 5 5 5 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EFX01344.1 - 0.0013 18.9 0.1 0.033 14.4 0.0 2.9 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Tti2 PF10521.9 EFX01344.1 - 0.0046 16.5 0.0 3.2 7.2 0.0 2.8 3 0 0 3 3 3 2 Tti2 family HEAT_PBS PF03130.16 EFX01344.1 - 0.0059 17.2 4.4 35 5.5 0.0 5.6 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat DUF3437 PF11919.8 EFX01344.1 - 0.17 11.8 0.1 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Slx4 PF09494.10 EFX01345.1 - 2.1e-21 75.6 0.2 4.6e-21 74.5 0.2 1.6 1 0 0 1 1 1 1 Slx4 endonuclease Mur_ligase_M PF08245.12 EFX01346.1 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Dynamin_N PF00350.23 EFX01347.1 - 6.5e-30 104.4 0.2 1.5e-29 103.2 0.2 1.7 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFX01347.1 - 2.2e-19 69.8 0.0 6.7e-16 58.3 0.0 2.4 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EFX01347.1 - 1.9e-07 31.2 0.1 8e-07 29.1 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX01347.1 - 0.0035 16.9 0.1 0.34 10.4 0.2 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B GED PF02212.18 EFX01347.1 - 0.025 14.7 2.2 0.033 14.3 0.0 2.3 3 0 0 3 3 3 0 Dynamin GTPase effector domain AAA_15 PF13175.6 EFX01347.1 - 0.042 13.5 0.1 0.16 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 EFX01347.1 - 0.043 13.6 0.0 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 EFX01347.1 - 0.096 12.9 0.1 0.83 9.9 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EFX01347.1 - 0.29 11.6 2.1 2.4 8.6 2.1 2.3 1 1 0 1 1 1 0 AAA domain VHS PF00790.19 EFX01348.1 - 1.1e-31 109.6 5.7 8.9e-31 106.6 0.6 3.1 2 1 1 3 3 3 1 VHS domain FYVE PF01363.21 EFX01348.1 - 6.8e-15 55.0 3.6 1.1e-14 54.2 3.6 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EFX01348.1 - 2.5e-06 27.0 20.8 0.0006 19.5 2.1 3.5 3 0 0 3 3 3 2 Ubiquitin interaction motif GAT PF03127.14 EFX01348.1 - 2.3e-05 24.6 0.0 5.8e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 GAT domain FYVE_2 PF02318.16 EFX01348.1 - 0.14 12.3 1.9 0.3 11.3 1.9 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Fer4_2 PF12797.7 EFX01348.1 - 2 8.7 8.2 2.5 8.4 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Ribonuc_L-PSP PF01042.21 EFX01349.1 - 0.093 12.7 3.8 0.33 11.0 0.6 2.4 2 1 0 2 2 2 0 Endoribonuclease L-PSP Bax1-I PF01027.20 EFX01350.1 - 7.4e-37 127.2 7.9 1.3e-36 126.4 7.9 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Ndc80_HEC PF03801.13 EFX01351.1 - 1.1e-58 197.2 0.0 3e-58 195.8 0.0 1.8 2 0 0 2 2 2 1 HEC/Ndc80p family Spc7 PF08317.11 EFX01351.1 - 0.002 17.1 13.2 0.002 17.1 13.2 3.2 2 1 1 3 3 3 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EFX01351.1 - 3.1 7.9 49.6 0.027 14.5 13.0 3.8 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein ICL PF00463.21 EFX01352.1 - 5.4e-267 886.4 1.7 9e-267 885.7 1.7 1.3 1 1 0 1 1 1 1 Isocitrate lyase family BAR_2 PF10455.9 EFX01353.1 - 0.12 11.5 0.2 0.2 10.7 0.2 1.2 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Ysc84 PF04366.12 EFX01355.1 - 1.6e-39 134.6 0.1 2.5e-39 133.9 0.1 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EFX01355.1 - 2.6e-14 52.6 0.2 7e-14 51.2 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EFX01355.1 - 1.7e-12 46.8 0.1 5.9e-12 45.1 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EFX01355.1 - 3.1e-12 46.2 0.0 5.3e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 EFX01355.1 - 0.054 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Sec23_trunk PF04811.15 EFX01356.1 - 4.7e-78 262.1 0.0 6.7e-78 261.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFX01356.1 - 1.6e-30 105.7 0.3 3.2e-30 104.7 0.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EFX01356.1 - 9.8e-26 89.6 0.5 3.4e-25 87.8 0.1 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EFX01356.1 - 4.4e-16 58.6 5.9 8.3e-16 57.8 5.9 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFX01356.1 - 1.3e-15 57.1 0.0 6.8e-15 54.7 0.0 2.1 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EFX01356.1 - 0.033 13.6 1.0 0.073 12.5 0.1 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Methyltransf_34 PF11312.8 EFX01357.1 - 3.3e-70 236.8 0.0 5.5e-36 124.4 0.0 2.9 1 1 1 2 2 2 2 Putative SAM-dependent methyltransferase TetR_C_20 PF17925.1 EFX01357.1 - 0.34 11.2 2.9 8.1 6.8 0.4 2.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain MAPEG PF01124.18 EFX01358.1 - 6.9e-21 74.5 1.3 7.9e-21 74.3 1.3 1.1 1 0 0 1 1 1 1 MAPEG family Ribosomal_L22 PF00237.19 EFX01359.1 - 1.2e-41 141.1 0.1 1.7e-41 140.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S3Ae PF01015.18 EFX01360.1 - 1.7e-89 298.8 2.9 2.2e-89 298.4 2.9 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Ras PF00071.22 EFX01360.1 - 2.9e-27 95.2 0.0 2e-19 69.8 0.0 2.6 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFX01360.1 - 8.3e-17 61.5 0.0 4.2e-07 30.2 0.0 3.0 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX01360.1 - 0.00053 19.5 0.0 0.025 14.0 0.0 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX01360.1 - 0.00061 19.9 0.0 0.0028 17.7 0.0 2.1 2 2 0 2 2 2 1 50S ribosome-binding GTPase TniB PF05621.11 EFX01360.1 - 0.0076 15.7 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_22 PF13401.6 EFX01360.1 - 0.011 16.1 1.9 0.81 10.0 0.0 3.3 3 1 1 4 4 4 0 AAA domain AAA_14 PF13173.6 EFX01360.1 - 0.022 14.8 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain SUI1 PF01253.22 EFX01360.1 - 0.056 14.0 0.1 0.18 12.3 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor SUI1 ATPase_2 PF01637.18 EFX01360.1 - 0.12 12.2 0.1 1.1 9.1 0.0 2.3 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EFX01360.1 - 0.16 11.7 0.1 0.6 9.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain NEMO PF11577.8 EFX01360.1 - 0.18 11.8 0.0 0.48 10.5 0.0 1.7 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO POT1 PF02765.17 EFX01361.1 - 5.9e-10 39.2 0.0 1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 WD40 PF00400.32 EFX01362.1 - 3.9e-19 68.6 16.4 0.00059 20.6 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01362.1 - 9.4e-15 54.7 6.4 4.2e-06 27.0 0.5 4.2 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX01362.1 - 4.3e-06 26.8 0.2 0.0033 17.3 0.1 3.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A tRNA_anti-like PF12869.7 EFX01362.1 - 0.036 13.7 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 tRNA_anti-like Ge1_WD40 PF16529.5 EFX01362.1 - 0.054 12.4 0.1 0.56 9.1 0.0 2.3 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RabGAP-TBC PF00566.18 EFX01363.1 - 3.1e-47 161.0 0.0 1.7e-46 158.6 0.0 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain UPRTase PF14681.6 EFX01364.1 - 1.6e-78 262.9 0.0 1.9e-78 262.6 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFX01364.1 - 0.0075 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain 2OG-FeII_Oxy_3 PF13640.6 EFX01365.1 - 4.3e-08 34.0 0.1 8.1e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RsbU_N PF08673.10 EFX01365.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain Anp1 PF03452.14 EFX01367.1 - 2.2e-107 358.4 0.0 2.6e-107 358.1 0.0 1.1 1 0 0 1 1 1 1 Anp1 CHZ PF09649.10 EFX01369.1 - 0.0021 17.5 2.5 0.0085 15.5 0.1 2.7 2 0 0 2 2 2 1 Histone chaperone domain CHZ Zn_clus PF00172.18 EFX01369.1 - 0.0072 16.4 12.3 0.0072 16.4 12.3 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2610 PF11020.8 EFX01370.1 - 0.098 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2610) SipA_VBS PF17985.1 EFX01370.1 - 0.15 12.0 0.8 0.66 10.0 0.1 2.4 2 0 0 2 2 2 0 SipA vinculin binding site Aminotran_4 PF01063.19 EFX01371.1 - 5.9e-35 121.1 0.0 7.9e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Aldose_epim PF01263.20 EFX01372.1 - 4.6e-51 173.9 0.0 6.2e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase NHase_alpha PF02979.16 EFX01372.1 - 0.094 12.0 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain Bacteriocin_IIi PF11758.8 EFX01372.1 - 0.39 10.6 1.6 0.73 9.7 1.6 1.4 1 0 0 1 1 1 0 Aureocin-like type II bacteriocin Cation_efflux PF01545.21 EFX01373.1 - 1.8e-19 70.3 9.1 2.4e-19 69.9 9.1 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFX01373.1 - 1e-09 38.3 0.5 2.1e-09 37.4 0.5 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter EspB PF05802.11 EFX01373.1 - 0.16 12.0 2.3 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 Enterobacterial EspB protein DUF4741 PF15897.5 EFX01373.1 - 0.26 11.1 3.7 0.34 10.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4741) ABC_tran PF00005.27 EFX01374.1 - 3.3e-45 153.9 0.0 4.4e-21 75.8 0.0 3.1 3 1 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EFX01374.1 - 5.6e-21 74.4 5.9 5.6e-21 74.4 5.9 4.0 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 EFX01374.1 - 3.3e-14 53.4 8.7 0.00074 19.4 0.0 4.7 3 2 1 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX01374.1 - 2e-11 43.8 0.2 0.0078 15.7 0.0 4.5 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFX01374.1 - 9.4e-07 29.5 11.7 0.02 15.4 0.0 4.4 5 0 0 5 5 4 2 AAA domain MMR_HSR1 PF01926.23 EFX01374.1 - 1.3e-06 28.5 0.0 0.015 15.4 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 EFX01374.1 - 2.7e-06 27.9 0.1 0.066 13.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EFX01374.1 - 5.1e-06 26.1 0.0 0.063 13.0 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFX01374.1 - 1.6e-05 25.4 0.8 0.026 14.9 0.3 3.0 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EFX01374.1 - 2.3e-05 24.6 0.0 0.19 11.9 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFX01374.1 - 3.7e-05 24.0 0.2 0.6 10.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFX01374.1 - 8.6e-05 22.5 1.3 0.071 13.0 0.0 3.0 3 0 0 3 3 3 1 RsgA GTPase AAA_15 PF13175.6 EFX01374.1 - 0.00016 21.5 7.8 0.4 10.3 0.0 4.6 6 0 0 6 6 6 2 AAA ATPase domain AAA PF00004.29 EFX01374.1 - 0.00083 19.8 0.0 2 8.9 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFX01374.1 - 0.00093 19.0 0.5 2.4 7.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EFX01374.1 - 0.0022 18.2 3.9 0.56 10.4 0.0 3.2 3 0 0 3 3 2 2 AAA domain cobW PF02492.19 EFX01374.1 - 0.0035 17.0 0.6 3 7.4 0.3 2.6 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFX01374.1 - 0.0036 16.3 0.5 0.93 8.4 0.0 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_14 PF13173.6 EFX01374.1 - 0.0046 17.0 0.5 2.6 8.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFX01374.1 - 0.014 15.8 0.0 5.5 7.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 EFX01374.1 - 0.015 15.2 0.1 1.6 8.6 0.1 2.6 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 EFX01374.1 - 0.021 14.8 0.2 4 7.3 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 EFX01374.1 - 0.023 14.2 0.0 3.2 7.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFX01374.1 - 0.025 14.6 0.2 6.9 6.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Roc PF08477.13 EFX01374.1 - 0.036 14.3 0.1 5.1 7.3 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 EFX01374.1 - 0.038 13.7 0.0 0.66 9.6 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain SRP54 PF00448.22 EFX01374.1 - 0.046 13.3 0.0 3.6 7.2 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_27 PF13514.6 EFX01374.1 - 0.051 13.2 6.0 4.7 6.7 0.0 4.0 5 0 0 5 5 3 0 AAA domain FeoB_N PF02421.18 EFX01374.1 - 0.081 12.4 0.0 16 5.0 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EFX01374.1 - 0.21 11.6 8.6 7.9 6.5 0.0 4.3 3 1 0 3 3 2 0 Dynamin family Zeta_toxin PF06414.12 EFX01374.1 - 0.22 10.8 3.5 2.4 7.4 0.0 3.4 3 1 1 4 4 4 0 Zeta toxin Halo_GVPC PF05465.13 EFX01374.1 - 0.34 11.2 2.1 0.48 10.7 0.4 2.2 2 0 0 2 2 1 0 Halobacterial gas vesicle protein C (GVPC) repeat PRK PF00485.18 EFX01374.1 - 0.59 9.8 2.6 1.4 8.6 0.0 2.8 4 0 0 4 4 4 0 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.6 EFX01374.1 - 0.73 10.3 4.0 69 3.9 0.1 4.0 4 0 0 4 4 4 0 AAA domain Proteasome PF00227.26 EFX01375.1 - 3e-53 180.2 0.1 4.7e-53 179.5 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFX01375.1 - 1.8e-12 46.6 0.8 3.8e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature HET PF06985.11 EFX01376.1 - 8.8e-23 81.3 0.0 1.5e-22 80.6 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Isochorismatase PF00857.20 EFX01377.1 - 3.8e-32 111.9 0.5 1e-21 77.9 0.0 2.0 2 0 0 2 2 2 2 Isochorismatase family Pkinase PF00069.25 EFX01379.1 - 2.4e-61 207.4 0.0 2.9e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01379.1 - 7.5e-35 120.5 0.0 9.4e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX01379.1 - 5e-06 26.0 0.0 8.8e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFX01379.1 - 0.0023 17.3 0.1 0.004 16.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRV PF01816.17 EFX01379.1 - 0.36 11.3 2.7 5.6 7.6 0.2 3.9 3 0 0 3 3 3 0 Leucine rich repeat variant Band_7 PF01145.25 EFX01380.1 - 3.1e-23 82.7 8.7 4.8e-23 82.1 7.9 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EFX01380.1 - 0.0006 19.0 4.3 0.00082 18.5 4.3 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial PknG_rubred PF16919.5 EFX01380.1 - 0.052 13.7 0.1 0.092 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain Ribonuc_L-PSP PF01042.21 EFX01381.1 - 1.7e-38 131.4 0.1 1.9e-38 131.2 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Syja_N PF02383.18 EFX01383.1 - 4.2e-95 318.7 0.0 6.2e-95 318.2 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EFX01383.1 - 4.4e-40 136.0 0.0 1e-39 134.8 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase Phage_T4_Ndd PF06591.11 EFX01383.1 - 0.078 12.8 0.0 6.3 6.6 0.0 2.4 2 0 0 2 2 2 0 T4-like phage nuclear disruption protein (Ndd) UcrQ PF02939.16 EFX01384.1 - 1.8e-31 107.9 0.4 2.2e-31 107.6 0.4 1.1 1 0 0 1 1 1 1 UcrQ family Flavoprotein PF02441.19 EFX01385.1 - 3.3e-20 72.4 0.0 6.1e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 Flavoprotein F-box-like PF12937.7 EFX01385.1 - 0.97 9.4 0.0 0.97 9.4 0.0 3.3 3 0 0 3 3 3 0 F-box-like STAG PF08514.11 EFX01386.1 - 4.4e-34 116.8 0.1 1.5e-33 115.1 0.1 1.9 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.6 EFX01386.1 - 8.4e-06 26.1 0.5 0.00029 21.2 0.0 3.7 2 1 1 3 3 3 1 HEAT repeats YL1 PF05764.13 EFX01386.1 - 0.0046 17.1 8.6 0.0046 17.1 8.6 4.0 4 0 0 4 4 4 2 YL1 nuclear protein HEAT PF02985.22 EFX01386.1 - 0.14 12.5 0.9 55 4.4 0.0 4.4 5 0 0 5 5 5 0 HEAT repeat DUF1223 PF06764.11 EFX01387.1 - 1.5e-47 162.3 0.1 8.5e-33 114.1 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1223) Thioredoxin_3 PF13192.6 EFX01387.1 - 0.067 13.3 0.0 7.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain Tyrosinase PF00264.20 EFX01388.1 - 1.1e-30 107.6 0.0 2e-30 106.8 0.0 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EFX01388.1 - 2.1e-08 34.8 0.0 3.9e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Tyosinase C-terminal domain CENP-S PF15630.6 EFX01389.1 - 3e-32 110.8 0.0 3.9e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EFX01389.1 - 6.2e-08 32.7 0.1 7.2e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EFX01389.1 - 0.028 14.4 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID-18kDa PF02269.16 EFX01389.1 - 0.091 12.8 0.0 0.22 11.5 0.0 1.7 1 1 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit SHNi-TPR PF10516.9 EFX01390.1 - 4e-14 51.8 1.4 1.1e-13 50.3 0.1 2.4 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.6 EFX01390.1 - 2.9e-06 27.5 2.6 0.00087 19.5 0.3 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat SNAP PF14938.6 EFX01390.1 - 6.4e-05 22.5 1.1 0.00019 21.0 1.1 1.7 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 EFX01390.1 - 0.0027 17.8 3.5 0.011 15.9 2.5 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01390.1 - 0.0083 16.7 3.9 0.02 15.6 0.5 3.4 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFX01390.1 - 0.011 16.2 1.5 0.03 14.8 0.3 2.5 2 1 1 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFX01390.1 - 0.023 15.1 0.3 0.46 11.0 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFX01390.1 - 0.033 13.9 5.0 0.22 11.2 2.8 2.9 2 1 0 2 2 2 0 TPR repeat TPR_3 PF07720.12 EFX01390.1 - 0.036 14.1 1.9 0.089 12.8 1.9 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFX01390.1 - 0.05 13.5 0.7 0.05 13.5 0.7 2.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFX01390.1 - 0.052 13.6 0.3 0.052 13.6 0.3 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFX01390.1 - 0.071 13.0 3.6 0.18 11.6 3.3 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFX01390.1 - 0.32 11.9 3.1 0.71 10.8 0.6 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CAF1A PF12253.8 EFX01390.1 - 1.5 9.1 6.4 6.3 7.0 6.4 2.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A TPR_2 PF07719.17 EFX01390.1 - 1.9 8.8 13.9 0.076 13.2 4.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 EFX01390.1 - 4 7.6 8.3 0.7 10.0 2.9 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain BTK PF00779.19 EFX01391.1 - 0.24 11.3 1.3 0.5 10.2 1.3 1.5 1 0 0 1 1 1 0 BTK motif CHORD PF04968.12 EFX01391.1 - 0.49 11.1 3.2 3.4 8.5 0.3 2.8 1 1 1 2 2 2 0 CHORD cPLA2_C2 PF18695.1 EFX01392.1 - 0.11 12.5 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Cytosolic phospholipases A2 C2-domain RNA_pol_Rpc4 PF05132.14 EFX01393.1 - 1.6e-26 93.5 0.0 1.6e-26 93.5 0.0 3.7 5 0 0 5 5 5 1 RNA polymerase III RPC4 Pkinase PF00069.25 EFX01394.1 - 4.8e-38 131.0 0.0 1.8e-18 66.8 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01394.1 - 6.1e-24 84.7 0.0 7.8e-17 61.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase AMP-binding PF00501.28 EFX01395.1 - 1.2e-83 281.1 0.1 1.2e-83 281.1 0.1 1.7 2 0 0 2 2 2 1 AMP-binding enzyme UCH PF00443.29 EFX01395.1 - 8.8e-29 100.8 0.0 2.3e-26 92.8 0.0 3.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX01395.1 - 1.1e-13 51.4 0.8 2.9e-12 46.8 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EFX01395.1 - 0.00019 21.9 0.0 0.0005 20.6 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain PAT1 PF09770.9 EFX01395.1 - 1.7 6.8 36.6 0.048 11.9 30.1 1.6 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 EFX01395.1 - 3.7 7.1 20.4 13 5.3 15.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF572) TFIIA PF03153.13 EFX01395.1 - 4.1 7.3 46.8 0.95 9.4 42.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Thioredoxin PF00085.20 EFX01396.1 - 1.8e-59 198.1 0.1 1.4e-28 98.9 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin ERp29 PF07749.12 EFX01396.1 - 1.5e-26 93.2 2.8 5.6e-26 91.3 0.7 2.3 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EFX01396.1 - 1.1e-17 64.5 0.2 4.8e-08 33.4 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFX01396.1 - 1.5e-12 47.5 0.0 1.7e-05 24.3 0.0 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EFX01396.1 - 1.4e-09 38.0 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EFX01396.1 - 1.4e-09 38.0 0.0 0.00052 20.2 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 EFX01396.1 - 1.8e-09 37.8 0.0 0.0012 19.1 0.0 3.4 3 1 1 4 4 4 2 Thioredoxin-like TraF PF13728.6 EFX01396.1 - 2.6e-06 27.5 0.0 0.0045 16.8 0.0 2.8 3 0 0 3 3 3 2 F plasmid transfer operon protein Redoxin PF08534.10 EFX01396.1 - 2e-05 24.3 0.3 0.072 12.8 0.0 2.8 3 0 0 3 3 3 2 Redoxin Thioredoxin_6 PF13848.6 EFX01396.1 - 2.4e-05 24.3 0.9 0.42 10.5 0.0 3.5 3 1 1 4 4 4 2 Thioredoxin-like domain HyaE PF07449.11 EFX01396.1 - 9.7e-05 22.3 0.0 0.046 13.7 0.0 2.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE ERp29_N PF07912.13 EFX01396.1 - 0.00012 22.2 0.0 0.0014 18.8 0.0 2.3 2 1 0 2 2 2 1 ERp29, N-terminal domain Thioredoxin_9 PF14595.6 EFX01396.1 - 0.0003 20.6 0.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 EFX01396.1 - 0.00075 19.5 0.0 2.3 8.3 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EFX01396.1 - 0.00098 19.3 3.3 9 6.4 0.0 4.4 3 2 2 5 5 5 1 Thioredoxin Glutaredoxin PF00462.24 EFX01396.1 - 0.0012 19.0 0.3 3.6 7.9 0.0 3.1 2 1 0 2 2 2 2 Glutaredoxin YqeY PF09424.10 EFX01397.1 - 2.6e-19 69.7 1.6 3.5e-19 69.3 1.6 1.2 1 0 0 1 1 1 1 Yqey-like protein PCP_red PF08369.10 EFX01397.1 - 0.017 15.4 0.1 0.07 13.3 0.1 2.1 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit L-fibroin PF05849.11 EFX01397.1 - 0.056 12.7 0.7 0.083 12.2 0.7 1.2 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) DUF2017 PF09438.10 EFX01397.1 - 0.11 12.3 8.0 0.12 12.2 6.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2017) Eisosome1 PF12757.7 EFX01398.1 - 3e-41 140.6 14.4 3e-41 140.6 14.4 2.6 2 0 0 2 2 2 1 Eisosome protein 1 A_deaminase PF00962.22 EFX01399.1 - 2.6e-22 79.6 0.0 4.1e-17 62.5 0.0 2.3 2 0 0 2 2 2 2 Adenosine/AMP deaminase TAF4 PF05236.14 EFX01399.1 - 0.00023 21.0 6.7 0.00037 20.4 6.7 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Tim54 PF11711.8 EFX01399.1 - 0.0092 14.8 1.4 0.014 14.2 1.4 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 ART-PolyVal PF18760.1 EFX01399.1 - 0.011 16.7 2.1 0.02 15.9 2.1 1.5 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins AIF_C PF14721.6 EFX01399.1 - 0.058 13.8 2.0 0.14 12.5 2.0 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term AAA_11 PF13086.6 EFX01399.1 - 0.11 12.2 2.3 0.18 11.6 2.3 1.2 1 0 0 1 1 1 0 AAA domain CobT PF06213.12 EFX01399.1 - 0.32 10.3 10.9 0.5 9.7 10.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 EFX01399.1 - 0.36 11.2 5.6 0.74 10.2 5.6 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Connexin PF00029.19 EFX01399.1 - 0.71 9.6 3.1 1.2 8.8 3.1 1.2 1 0 0 1 1 1 0 Connexin DNA_pol_phi PF04931.13 EFX01399.1 - 0.75 7.8 9.8 1.1 7.3 9.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 EFX01399.1 - 0.91 8.2 7.8 1.4 7.6 7.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.6 EFX01399.1 - 1.2 8.8 6.7 2.1 8.0 6.7 1.3 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 EFX01399.1 - 3 6.5 4.1 4.6 5.9 4.1 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EFX01399.1 - 3.4 5.9 9.9 5.3 5.2 9.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 EFX01399.1 - 6.2 7.3 11.3 12 6.3 11.3 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RRN3 PF05327.11 EFX01399.1 - 9.8 4.6 9.1 15 4.0 9.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MFS_1 PF07690.16 EFX01400.1 - 2.1e-38 132.1 49.7 4e-38 131.3 49.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX01400.1 - 1.1e-12 47.2 27.0 1.6e-12 46.7 27.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) EF-hand_1 PF00036.32 EFX01401.1 - 8.8e-28 93.8 12.8 4.3e-07 29.0 0.6 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFX01401.1 - 6.6e-24 84.2 12.9 5.9e-14 52.3 1.5 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFX01401.1 - 5.1e-20 69.6 7.6 9.4e-05 22.1 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFX01401.1 - 8e-19 66.2 9.7 2.9e-06 26.5 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFX01401.1 - 2.7e-13 49.5 11.4 0.00017 21.4 0.5 4.3 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFX01401.1 - 3.2e-07 30.6 0.1 0.0016 18.8 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFX01401.1 - 5e-06 26.4 6.6 0.012 15.5 0.5 3.7 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFX01401.1 - 0.022 15.1 0.1 1.6 9.1 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain Dockerin_1 PF00404.18 EFX01401.1 - 0.043 14.0 1.6 0.29 11.4 1.7 2.3 1 1 1 2 2 2 0 Dockerin type I domain Aldolase_II PF00596.21 EFX01402.1 - 2.2e-49 167.9 1.5 3.4e-49 167.3 1.5 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain TB2_DP1_HVA22 PF03134.19 EFX01403.1 - 3.3e-26 91.0 8.4 5.7e-26 90.3 8.4 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Bestrophin PF01062.21 EFX01403.1 - 0.1 11.9 2.7 0.2 11.0 2.7 1.5 1 1 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel WD40 PF00400.32 EFX01404.1 - 4.2e-14 52.7 2.1 0.0057 17.5 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat PQQ PF01011.21 EFX01404.1 - 0.00014 21.6 0.5 2.2 8.4 0.1 3.6 3 0 0 3 3 3 2 PQQ enzyme repeat DUF5046 PF16465.5 EFX01404.1 - 0.0028 17.2 0.1 0.11 11.9 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5046) ANAPC4_WD40 PF12894.7 EFX01404.1 - 0.016 15.5 0.0 4.7 7.6 0.0 4.0 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain FMO-like PF00743.19 EFX01406.1 - 8.6e-26 90.4 0.0 1.6e-14 53.3 0.0 3.7 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX01406.1 - 7.4e-15 55.0 0.5 3e-09 36.6 0.1 3.1 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX01406.1 - 8.6e-12 44.9 0.0 6.6e-11 42.0 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX01406.1 - 3.4e-07 30.4 0.0 9e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFX01406.1 - 1.6e-05 24.3 0.2 0.00022 20.5 0.1 2.2 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 EFX01406.1 - 4.5e-05 22.8 0.7 0.00073 18.8 0.1 2.6 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFX01406.1 - 6.2e-05 23.0 4.3 0.00073 19.6 0.9 3.4 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EFX01406.1 - 0.0013 18.4 2.4 0.1 12.2 0.4 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFX01406.1 - 0.0019 17.5 0.1 0.0035 16.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EFX01406.1 - 0.0057 15.8 1.6 0.01 14.9 0.5 1.8 2 0 0 2 2 2 1 FAD binding domain MCRA PF06100.11 EFX01406.1 - 0.0058 15.5 0.1 0.52 9.0 0.0 2.1 2 0 0 2 2 2 1 MCRA family IlvN PF07991.12 EFX01406.1 - 0.0077 15.8 0.2 0.017 14.7 0.0 1.5 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Amino_oxidase PF01593.24 EFX01406.1 - 0.012 15.0 0.1 0.98 8.6 0.0 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EFX01406.1 - 0.046 12.4 0.4 0.099 11.3 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 EFX01406.1 - 0.13 11.6 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EFX01407.1 - 1.3e-52 177.8 0.0 2e-52 177.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX01407.1 - 3.4e-34 117.4 0.0 4.7e-34 116.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFX01407.1 - 4.6e-05 23.6 0.5 0.00011 22.4 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EFX01407.1 - 0.003 17.7 0.2 0.0091 16.1 0.0 1.8 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 EFX01407.1 - 0.018 15.5 0.1 0.089 13.3 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain ACT PF01842.25 EFX01407.1 - 0.032 14.0 0.4 0.1 12.4 0.0 2.1 2 0 0 2 2 2 0 ACT domain IlvN PF07991.12 EFX01407.1 - 0.07 12.7 0.1 0.4 10.2 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lipoxygenase PF00305.19 EFX01408.1 - 1.2e-21 76.8 0.0 2e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Lipoxygenase DUF1833 PF08875.11 EFX01408.1 - 0.05 13.1 0.0 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1833) DUF1793 PF08760.11 EFX01409.1 - 2e-72 243.0 0.0 4.8e-72 241.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EFX01409.1 - 1.7e-62 210.1 0.9 1.3e-49 168.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EFX01409.1 - 2e-41 142.3 0.2 5.4e-41 140.8 0.2 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 EFX01409.1 - 0.00042 19.8 0.1 0.00093 18.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) UbiD PF01977.16 EFX01410.1 - 1.2e-120 403.1 0.0 1.4e-120 402.9 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AAA_12 PF13087.6 EFX01411.1 - 3.9e-37 127.8 0.0 1.4e-36 126.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFX01411.1 - 2.7e-24 86.4 0.0 9e-24 84.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX01411.1 - 3e-10 40.6 0.0 3.9e-09 37.0 0.0 2.8 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EFX01411.1 - 1.9e-06 27.4 0.2 0.0029 16.9 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EFX01411.1 - 1.3e-05 25.0 0.0 0.0018 18.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain DRMBL PF07522.14 EFX01411.1 - 0.00015 21.9 0.0 0.00034 20.8 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase ResIII PF04851.15 EFX01411.1 - 0.00086 19.3 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EFX01411.1 - 0.002 17.7 0.0 0.0045 16.5 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Arb2 PF09757.9 EFX01411.1 - 0.036 13.2 0.0 0.16 11.1 0.0 1.9 2 0 0 2 2 2 0 Arb2 domain PhoH PF02562.16 EFX01411.1 - 0.18 11.2 0.1 0.41 10.1 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Cu-oxidase_2 PF07731.14 EFX01412.1 - 7.4e-48 161.8 5.4 1.8e-40 137.8 0.1 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFX01412.1 - 1.7e-41 141.0 4.8 1.1e-39 135.1 1.6 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX01412.1 - 1.1e-30 106.9 4.8 9.6e-29 100.6 0.3 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EFX01412.1 - 0.0032 17.6 0.0 1.9 8.7 0.0 3.5 4 0 0 4 4 4 1 Cupredoxin-like domain Spermine_synth PF01564.17 EFX01413.1 - 1e-05 25.0 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EFX01413.1 - 0.041 13.7 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain zf-C2H2 PF00096.26 EFX01414.1 - 0.0087 16.5 22.9 3.3 8.3 0.4 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type Gal4_dimer PF03902.13 EFX01414.1 - 0.094 12.9 0.2 0.094 12.9 0.2 1.8 2 0 0 2 2 2 0 Gal4-like dimerisation domain zf-C2H2_4 PF13894.6 EFX01414.1 - 1.2 10.1 23.2 3 8.9 0.7 5.4 5 1 0 5 5 5 0 C2H2-type zinc finger DUF874 PF05917.11 EFX01415.1 - 0.0045 16.1 12.0 0.0071 15.4 12.0 1.2 1 0 0 1 1 1 1 Helicobacter pylori protein of unknown function (DUF874) ERM PF00769.19 EFX01415.1 - 0.084 12.7 23.2 0.011 15.5 19.1 1.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Borrelia_P83 PF05262.11 EFX01415.1 - 0.8 8.1 17.5 1.2 7.6 17.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4490 PF14892.6 EFX01415.1 - 1 9.4 3.1 0.82 9.8 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4490) DUF913 PF06025.12 EFX01415.1 - 1.4 7.8 3.8 2.8 6.8 3.8 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PIEZO PF15917.5 EFX01415.1 - 1.8 8.0 10.3 4 6.9 10.3 1.5 1 0 0 1 1 1 0 Piezo Tho2 PF11262.8 EFX01415.1 - 1.8 7.7 8.0 2.8 7.1 8.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3584 PF12128.8 EFX01415.1 - 4.6 4.6 15.4 6.3 4.2 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_11 PF13086.6 EFX01415.1 - 5.5 6.7 10.8 9 6.0 10.8 1.2 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 EFX01415.1 - 8.3 5.7 15.1 14 4.9 15.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NAP PF00956.18 EFX01416.1 - 1.7e-100 335.7 10.1 1.7e-100 335.7 10.1 1.4 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 EFX01416.1 - 0.51 10.0 25.0 0.58 9.8 15.7 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.13 EFX01416.1 - 0.82 9.6 20.3 1.6 8.6 20.3 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Striatin PF08232.12 EFX01416.1 - 1.2 9.7 10.4 1 9.9 7.5 2.3 1 1 1 2 2 2 0 Striatin family Nop14 PF04147.12 EFX01416.1 - 2.6 6.2 27.7 0.6 8.2 16.0 2.1 2 0 0 2 2 2 0 Nop14-like family RRP36 PF06102.12 EFX01417.1 - 2.5e-48 164.2 19.6 2.5e-48 164.2 19.6 1.9 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 DUF3365 PF11845.8 EFX01417.1 - 0.64 10.3 3.2 1.7 8.9 3.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) WAPL PF07814.13 EFX01418.1 - 2.7e-52 177.8 0.0 4.9e-52 176.9 0.0 1.4 1 1 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin SCAMP PF04144.13 EFX01418.1 - 0.23 11.8 0.0 0.37 11.1 0.0 1.2 1 0 0 1 1 1 0 SCAMP family NIF PF03031.18 EFX01419.1 - 1.2e-56 190.8 0.0 1.7e-56 190.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pyr_redox_2 PF07992.14 EFX01420.1 - 1.7e-11 43.9 0.0 6e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX01420.1 - 0.0093 15.6 0.5 0.022 14.4 0.2 1.8 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX01420.1 - 0.011 15.7 0.0 0.22 11.5 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFX01420.1 - 0.049 12.9 0.0 0.51 9.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain DHDPS PF00701.22 EFX01421.1 - 9.3e-37 126.3 0.0 2.4e-36 124.9 0.0 1.5 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family CGI-121 PF08617.10 EFX01422.1 - 6.4e-50 169.4 0.0 7.5e-50 169.2 0.0 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 UBX PF00789.20 EFX01423.1 - 5.5e-06 26.5 0.0 1.3e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 UBX domain UBA PF00627.31 EFX01423.1 - 0.0044 16.9 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain zf-C2H2_2 PF12756.7 EFX01423.1 - 0.039 14.3 0.1 0.083 13.2 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Trm112p PF03966.16 EFX01423.1 - 0.061 13.9 0.2 0.28 11.8 0.0 2.1 2 1 0 2 2 2 0 Trm112p-like protein zf-C2H2 PF00096.26 EFX01423.1 - 0.25 11.9 0.0 0.56 10.8 0.0 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type FAM167 PF11652.8 EFX01423.1 - 0.89 10.1 5.6 19 5.8 5.1 2.8 3 0 0 3 3 3 0 FAM167 Atg14 PF10186.9 EFX01423.1 - 1.6 7.7 19.0 2.3 7.2 19.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RskA PF10099.9 EFX01423.1 - 4.4 7.6 19.3 0.027 14.8 7.8 2.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF3455 PF11937.8 EFX01424.1 - 4e-46 157.3 1.5 1.3e-45 155.6 1.5 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) Tic110 PF16940.5 EFX01424.1 - 0.18 10.2 0.1 0.28 9.6 0.1 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Mid1 PF12929.7 EFX01426.1 - 2.2e-153 511.4 8.9 3.2e-153 510.9 8.9 1.2 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EFX01426.1 - 0.00013 22.5 6.2 0.0063 17.1 2.3 2.5 2 0 0 2 2 2 2 Fz domain DUF4417 PF14386.6 EFX01426.1 - 0.029 14.0 0.1 0.053 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) TBP PF00352.21 EFX01427.1 - 1.7e-66 220.2 0.1 6.6e-32 109.3 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EFX01427.1 - 0.00014 21.9 0.0 0.25 11.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EFX01427.1 - 0.037 13.8 0.1 0.27 11.1 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) Elf1 PF05129.13 EFX01428.1 - 2.5e-29 101.1 0.3 3.1e-29 100.8 0.3 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like PHD_4 PF16866.5 EFX01428.1 - 0.015 15.4 0.7 0.025 14.7 0.7 1.3 1 0 0 1 1 1 0 PHD-finger UCR_hinge PF02320.16 EFX01429.1 - 2.2e-26 91.8 10.6 2.2e-26 91.8 10.6 1.8 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein DUF4471 PF14740.6 EFX01429.1 - 0.011 15.0 1.6 0.013 14.7 1.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) RR_TM4-6 PF06459.12 EFX01429.1 - 0.13 12.0 7.4 0.15 11.8 7.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3391 PF11871.8 EFX01429.1 - 0.36 11.3 8.7 0.45 11.0 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) PTPRCAP PF15713.5 EFX01429.1 - 0.53 10.6 10.9 0.71 10.2 10.9 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated HSP70 PF00012.20 EFX01429.1 - 0.71 8.0 6.9 0.79 7.8 6.9 1.0 1 0 0 1 1 1 0 Hsp70 protein Presenilin PF01080.17 EFX01429.1 - 1 8.0 3.3 1.1 7.9 3.3 1.0 1 0 0 1 1 1 0 Presenilin TRAP_alpha PF03896.16 EFX01429.1 - 10 5.3 7.7 11 5.1 7.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Exo_endo_phos PF03372.23 EFX01430.1 - 1.1e-05 25.1 3.1 2.4e-05 24.0 3.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UQ_con PF00179.26 EFX01431.1 - 7.3e-53 178.0 0.0 8.2e-53 177.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX01431.1 - 0.0097 15.6 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFX01431.1 - 0.057 13.7 0.0 0.07 13.4 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EFX01431.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain Glyco_hydro_3 PF00933.21 EFX01432.1 - 2.6e-60 204.5 0.0 3.6e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFX01432.1 - 0.0039 17.2 0.0 0.0077 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_1 PF00583.25 EFX01432.1 - 0.043 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF5320 PF17253.2 EFX01432.1 - 0.92 10.6 3.4 1.8 9.6 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5320) TRAM_LAG1_CLN8 PF03798.16 EFX01433.1 - 2e-48 164.8 8.1 2.9e-48 164.2 8.1 1.2 1 0 0 1 1 1 1 TLC domain LYRIC PF15686.5 EFX01433.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF676 PF05057.14 EFX01434.1 - 1.1e-50 172.2 0.0 1.7e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EFX01434.1 - 1.3e-05 25.9 0.9 1.3e-05 25.9 0.9 1.9 1 1 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EFX01434.1 - 0.0012 18.6 0.1 0.012 15.4 0.1 2.1 1 1 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EFX01434.1 - 0.0032 17.3 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Pyridox_ox_2 PF12900.7 EFX01436.1 - 5.7e-33 113.9 0.0 9.1e-33 113.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase zf-piccolo PF05715.13 EFX01437.1 - 1.9 8.7 8.9 0.42 10.8 2.7 2.6 2 0 0 2 2 2 0 Piccolo Zn-finger IBR PF01485.21 EFX01437.1 - 3.9 7.8 10.5 0.77 10.0 0.7 3.3 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain FYVE_2 PF02318.16 EFX01437.1 - 5.1 7.3 10.6 5.6 7.2 4.9 2.9 2 1 0 2 2 2 0 FYVE-type zinc finger zf-B_box PF00643.24 EFX01437.1 - 8.5 6.6 12.3 1.3 9.3 1.3 3.1 3 1 0 3 3 3 0 B-box zinc finger WD40 PF00400.32 EFX01438.1 - 7.1e-44 146.9 15.0 7.2e-09 36.1 0.3 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01438.1 - 0.00022 21.5 0.2 3.7 7.9 0.0 4.6 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX01438.1 - 0.092 11.4 1.9 10 4.6 0.0 3.5 1 1 2 4 4 4 0 Nucleoporin Nup120/160 ApbA_C PF08546.11 EFX01439.1 - 5.5e-28 97.7 0.0 1.1e-27 96.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFX01439.1 - 8.7e-27 93.6 0.2 1.3e-26 93.1 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Methyltransf_23 PF13489.6 EFX01440.1 - 4.8e-10 39.5 0.0 6.7e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01440.1 - 5.5e-06 26.9 0.0 1e-05 26.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX01440.1 - 0.00013 22.6 0.0 0.00034 21.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01440.1 - 0.061 14.1 0.0 0.33 11.7 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01440.1 - 0.074 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.12 EFX01440.1 - 0.12 11.9 0.1 0.21 11.1 0.0 1.4 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase AAA PF00004.29 EFX01441.1 - 2.4e-18 66.8 0.0 5.4e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX01441.1 - 0.0016 18.8 0.7 0.0085 16.5 0.3 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFX01441.1 - 0.04 14.2 0.3 0.14 12.5 0.3 1.9 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFX01441.1 - 0.061 13.1 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFX01441.1 - 0.065 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CPT PF07931.12 EFX01441.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Hydin_ADK PF17213.3 EFX01441.1 - 0.31 11.3 0.1 0.31 11.3 0.1 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Pro_dh PF01619.18 EFX01442.1 - 1.9e-69 234.5 0.0 2.3e-69 234.2 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase HLH PF00010.26 EFX01443.1 - 5.3e-16 58.3 0.0 1.2e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tropomyosin PF00261.20 EFX01443.1 - 0.025 14.0 0.9 0.043 13.2 0.9 1.3 1 0 0 1 1 1 0 Tropomyosin ABC_tran PF00005.27 EFX01444.1 - 7.8e-16 58.8 0.0 2.9e-15 57.0 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFX01444.1 - 5.1e-08 33.1 0.2 0.00041 20.3 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EFX01444.1 - 0.0019 17.8 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF3584 PF12128.8 EFX01444.1 - 0.0021 15.7 0.5 0.0027 15.3 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_29 PF13555.6 EFX01444.1 - 0.0032 17.2 0.2 0.0081 15.9 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFX01444.1 - 0.0059 17.1 0.2 0.0087 16.6 0.2 1.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFX01444.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 EFX01444.1 - 0.026 14.0 0.0 3.7 6.9 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFX01444.1 - 0.044 14.2 0.1 0.089 13.2 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EFX01444.1 - 0.048 13.9 0.7 0.09 13.0 0.2 1.7 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EFX01444.1 - 0.055 13.2 0.0 0.08 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 EFX01444.1 - 0.087 12.4 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EFX01444.1 - 0.1 12.8 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFX01444.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 EFX01444.1 - 0.14 11.6 0.2 0.39 10.1 0.1 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA PF00004.29 EFX01444.1 - 0.19 12.1 0.1 0.4 11.1 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 EFX01444.1 - 0.19 10.3 0.0 0.26 9.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFX01444.1 - 0.2 12.0 0.1 0.39 11.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFX01444.1 - 0.2 11.6 0.2 0.38 10.7 0.2 1.4 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 EFX01444.1 - 0.24 11.0 0.3 0.43 10.1 0.3 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DLIC PF05783.11 EFX01444.1 - 0.28 10.0 0.1 0.42 9.4 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) TRAP_alpha PF03896.16 EFX01445.1 - 6.1e-06 25.7 0.1 2.4e-05 23.7 0.1 1.8 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit SF1-HH PF16275.5 EFX01446.1 - 1.7e-43 147.5 6.2 7e-43 145.6 1.0 2.4 1 1 1 2 2 2 1 Splicing factor 1 helix-hairpin domain GST_N PF02798.20 EFX01446.1 - 1.5e-12 47.7 0.0 2.8e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFX01446.1 - 3.2e-12 46.7 0.0 6.3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain zf-CCHC PF00098.23 EFX01446.1 - 1.7e-11 43.6 13.5 9.9e-06 25.4 0.7 3.0 3 0 0 3 3 3 2 Zinc knuckle GST_N_2 PF13409.6 EFX01446.1 - 8e-10 38.9 0.0 2e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain KH_1 PF00013.29 EFX01446.1 - 9.2e-09 35.0 0.1 1.7e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 EFX01446.1 - 3.3e-05 23.8 7.1 0.0029 17.5 3.4 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EFX01446.1 - 0.001 18.9 7.1 0.19 11.6 0.9 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EFX01446.1 - 0.0046 16.7 5.2 0.64 9.8 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 EFX01446.1 - 0.01 15.7 0.4 0.01 15.7 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle PHD_4 PF16866.5 EFX01446.1 - 0.36 10.9 1.8 0.74 10.0 1.8 1.5 1 0 0 1 1 1 0 PHD-finger eIF3g PF12353.8 EFX01446.1 - 6.1 7.3 7.4 48 4.4 5.1 2.9 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Glyco_hydro_16 PF00722.21 EFX01447.1 - 1.7e-43 148.1 3.1 1.7e-43 148.1 3.1 2.1 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 SOG2 PF10428.9 EFX01447.1 - 0.88 8.7 23.0 1.1 8.4 23.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein RIFIN PF02009.16 EFX01447.1 - 1.9 8.3 3.7 2.7 7.8 3.7 1.4 1 0 0 1 1 1 0 Rifin KH_2 PF07650.17 EFX01448.1 - 0.17 11.8 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 KH domain Glyco_hydro_47 PF01532.20 EFX01449.1 - 3.8e-165 550.2 0.2 4.6e-165 549.9 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CMD PF02627.20 EFX01450.1 - 0.004 17.2 0.3 0.021 14.9 0.0 2.1 2 1 0 2 2 2 1 Carboxymuconolactone decarboxylase family HNH_2 PF13391.6 EFX01451.1 - 3.2e-11 43.2 0.1 5.8e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 HNH endonuclease Peptidase_S32 PF05579.13 EFX01451.1 - 0.17 11.1 0.1 0.25 10.5 0.1 1.3 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S3 PF00944.19 EFX01451.1 - 0.19 11.5 0.1 0.36 10.6 0.1 1.4 1 0 0 1 1 1 0 Alphavirus core protein LCCL PF03815.19 EFX01452.1 - 2.1e-17 63.0 0.0 3.4e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 LCCL domain PT-TG PF14449.6 EFX01452.1 - 0.29 11.0 0.9 15 5.6 0.0 2.6 2 0 0 2 2 2 0 Pre-toxin TG Fungal_trans_2 PF11951.8 EFX01453.1 - 4.8e-19 68.4 0.2 4.7e-15 55.3 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Fungal_trans PF04082.18 EFX01453.1 - 0.0088 15.1 0.3 0.018 14.1 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GATase_5 PF13507.6 EFX01454.1 - 5.7e-93 310.8 0.0 8.4e-93 310.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EFX01454.1 - 1.2e-33 116.5 4.4 2.1e-23 83.2 0.8 2.8 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_linker PF18072.1 EFX01454.1 - 8.4e-22 77.5 0.0 1.7e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain FGAR-AT_N PF18076.1 EFX01454.1 - 3e-19 69.1 0.0 5.7e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal AIRS PF00586.24 EFX01454.1 - 0.11 13.2 0.2 6.9 7.4 0.0 3.0 3 0 0 3 3 3 0 AIR synthase related protein, N-terminal domain DUF1479 PF07350.12 EFX01455.1 - 9e-07 28.0 0.0 1.1e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Abhydrolase_3 PF07859.13 EFX01457.1 - 9.5e-16 58.3 0.0 1.8e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX01457.1 - 3.5e-09 36.4 0.0 4.6e-07 29.5 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFX01457.1 - 4.4e-05 23.3 0.0 0.00046 19.9 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 EFX01457.1 - 0.00024 19.9 0.0 0.033 12.9 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Esterase PF00756.20 EFX01457.1 - 0.00063 19.5 0.0 0.00093 18.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EFX01457.1 - 0.001 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EFX01457.1 - 0.0023 17.8 0.0 0.18 11.6 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 EFX01457.1 - 0.0027 17.3 0.0 0.0088 15.7 0.0 1.7 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase_phd PF10503.9 EFX01457.1 - 0.021 14.3 0.1 0.43 10.0 0.0 2.2 1 1 1 2 2 2 0 Esterase PHB depolymerase COesterase PF00135.28 EFX01457.1 - 0.027 13.4 0.0 0.056 12.3 0.0 1.4 1 0 0 1 1 1 0 Carboxylesterase family Peptidase_S28 PF05577.12 EFX01457.1 - 0.043 12.6 0.0 0.061 12.1 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 DLH PF01738.18 EFX01457.1 - 0.091 12.3 0.0 6.6 6.2 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF5615 PF18480.1 EFX01457.1 - 0.14 11.9 0.0 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) Ribosomal_L31 PF01197.18 EFX01458.1 - 1.1e-05 25.5 0.0 2e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 COX7a PF02238.15 EFX01459.1 - 5.1e-19 68.4 1.1 5.8e-19 68.2 1.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII HET PF06985.11 EFX01460.1 - 2.8e-20 73.2 0.0 2.5e-19 70.1 0.0 2.4 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NUC153 PF08159.12 EFX01460.1 - 1.6e-12 47.0 1.0 3.5e-12 45.9 1.0 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EFX01460.1 - 0.0033 18.2 0.0 0.34 11.8 0.0 3.8 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01460.1 - 0.0098 16.2 0.0 0.027 14.8 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain NmrA PF05368.13 EFX01462.1 - 6.7e-23 81.5 0.0 8.2e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX01462.1 - 2.5e-20 73.2 0.1 8.1e-20 71.5 0.1 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EFX01462.1 - 4e-06 27.1 0.5 1.5e-05 25.2 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFX01462.1 - 1.5e-05 24.6 0.1 5.4e-05 22.8 0.1 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EFX01462.1 - 0.0052 16.9 0.0 0.0091 16.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 EFX01462.1 - 0.034 13.6 1.0 0.066 12.7 0.2 1.9 2 0 0 2 2 2 0 short chain dehydrogenase DFP PF04127.15 EFX01462.1 - 0.057 13.2 1.2 0.07 13.0 0.4 1.5 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein 3Beta_HSD PF01073.19 EFX01462.1 - 0.075 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HSP90 PF00183.18 EFX01463.1 - 1.6e-220 733.4 28.9 1.9e-220 733.2 28.9 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFX01463.1 - 7.2e-16 58.7 0.1 1.4e-15 57.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFX01463.1 - 2.6e-10 40.2 0.1 9.1e-10 38.5 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 EFX01463.1 - 0.031 14.3 1.5 0.054 13.5 0.2 2.0 2 0 0 2 2 2 0 Tumour suppressor protein Methyltransf_10 PF05971.12 EFX01463.1 - 0.14 11.5 0.1 0.26 10.6 0.1 1.4 1 0 0 1 1 1 0 RNA methyltransferase DUF1676 PF07898.13 EFX01463.1 - 1.2 9.1 4.1 2.1 8.4 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) zf-rbx1 PF12678.7 EFX01464.1 - 1.9e-10 40.8 1.3 3.8e-10 39.9 1.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFX01464.1 - 1.7e-08 34.6 1.4 1.7e-08 34.6 1.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EFX01464.1 - 2e-06 27.6 1.6 3.3e-06 26.9 1.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX01464.1 - 5.5e-06 26.1 1.7 5.5e-06 26.1 1.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX01464.1 - 1.1e-05 25.2 1.6 2.1e-05 24.4 1.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFX01464.1 - 8.1e-05 22.6 0.3 8.1e-05 22.6 0.3 3.1 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFX01464.1 - 0.00028 20.7 2.7 0.00051 19.8 2.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFX01464.1 - 0.0004 20.2 1.0 0.0004 20.2 1.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EFX01464.1 - 0.0061 16.1 0.7 0.0061 16.1 0.7 1.7 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EFX01464.1 - 0.011 15.4 0.3 0.011 15.4 0.3 3.2 3 0 0 3 3 3 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EFX01464.1 - 0.012 15.7 0.9 0.032 14.3 0.9 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TMEM190 PF15431.6 EFX01464.1 - 0.016 15.4 0.1 0.032 14.4 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 190 SLATT_fungal PF18142.1 EFX01464.1 - 0.031 14.3 0.1 0.088 12.8 0.1 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain DUF2921 PF11145.8 EFX01464.1 - 0.094 10.5 0.0 0.17 9.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) zf-C3H2C3 PF17122.5 EFX01464.1 - 9.1 6.4 6.5 7.8 6.6 1.6 2.4 2 0 0 2 2 2 0 Zinc-finger SRP40_C PF05022.12 EFX01465.1 - 2.2e-23 82.9 2.6 2.2e-23 82.9 2.6 2.4 3 0 0 3 3 3 1 SRP40, C-terminal domain Astro_capsid_p PF12226.8 EFX01465.1 - 8.1 5.5 36.5 0.042 13.0 9.3 2.6 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Drf_GBD PF06371.13 EFX01466.1 - 1.4e-12 47.5 0.0 5.6e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain DUF2514 PF10721.9 EFX01466.1 - 0.93 9.5 8.5 2.9 7.9 8.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) FlaC_arch PF05377.11 EFX01467.1 - 0.00096 19.5 31.1 0.35 11.3 1.0 7.2 8 0 0 8 8 8 3 Flagella accessory protein C (FlaC) Filament PF00038.21 EFX01467.1 - 0.001 18.7 16.0 0.001 18.7 16.0 4.9 3 1 1 6 6 6 1 Intermediate filament protein GAS PF13851.6 EFX01467.1 - 0.0015 17.9 1.8 0.0015 17.9 1.8 5.1 3 1 2 5 5 5 2 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EFX01467.1 - 0.0017 18.6 14.4 0.0017 18.6 14.4 6.4 3 2 2 5 5 4 1 Autophagy protein 16 (ATG16) CEP63 PF17045.5 EFX01467.1 - 0.0084 16.0 4.8 0.0084 16.0 4.8 4.4 3 1 1 4 4 4 1 Centrosomal protein of 63 kDa MCC-bdg_PDZ PF10506.9 EFX01467.1 - 0.067 13.2 14.6 4.2 7.4 1.1 5.5 5 1 0 6 6 6 0 PDZ domain of MCC-2 bdg protein for Usher syndrome bZIP_1 PF00170.21 EFX01467.1 - 0.077 13.1 0.2 0.077 13.1 0.2 7.9 9 0 0 9 9 9 0 bZIP transcription factor NPV_P10 PF05531.12 EFX01467.1 - 0.17 12.4 5.8 12 6.4 0.1 4.0 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EFX01467.1 - 0.19 11.8 13.8 0.48 10.5 3.9 4.0 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) HOOK PF05622.12 EFX01467.1 - 0.66 8.1 54.3 0.0052 15.0 5.1 3.1 3 0 0 3 3 3 0 HOOK protein BLOC1_2 PF10046.9 EFX01467.1 - 2.2 8.7 21.5 0.59 10.5 0.1 4.7 3 2 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PS_Dcarbxylase PF02666.15 EFX01468.1 - 5.4e-75 251.3 0.0 5.6e-74 248.0 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Cyt_b-c1_8 PF10890.8 EFX01468.1 - 0.11 12.9 0.0 5.7 7.4 0.0 2.5 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 Complex1_51K PF01512.17 EFX01469.1 - 1.9e-47 161.0 0.0 2.9e-47 160.4 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EFX01469.1 - 1.5e-28 98.7 1.4 2e-28 98.3 0.2 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EFX01469.1 - 3.2e-09 36.5 0.0 7.8e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 SLBB domain Adaptin_N PF01602.20 EFX01470.1 - 4.9e-80 269.6 1.4 6.3e-79 265.9 1.4 2.1 1 1 0 1 1 1 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 EFX01470.1 - 0.026 14.6 0.1 6.3 7.0 0.0 2.9 2 0 0 2 2 2 0 V-ATPase subunit H Peptidase_S10 PF00450.22 EFX01471.1 - 4.8e-61 207.4 0.0 7.5e-61 206.8 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase ARID PF01388.21 EFX01472.1 - 7.1e-18 65.1 0.0 1.7e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain RFX_DNA_binding PF02257.15 EFX01472.1 - 0.019 15.6 0.1 0.072 13.7 0.0 1.9 2 0 0 2 2 2 0 RFX DNA-binding domain TGT PF01702.18 EFX01473.1 - 7.3e-41 140.5 0.0 9.2e-41 140.1 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.16 EFX01474.1 - 5.6e-37 127.5 60.9 5.6e-32 111.0 55.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2627 PF11118.8 EFX01474.1 - 0.41 11.3 10.7 0.69 10.5 0.7 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2627) Methyltransf_12 PF08242.12 EFX01475.1 - 2.8e-13 50.4 0.0 5.7e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX01475.1 - 3.5e-13 50.1 0.0 6.7e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01475.1 - 4.5e-10 40.0 0.0 9.9e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX01475.1 - 4e-09 36.5 0.0 6.5e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01475.1 - 2.4e-07 30.7 0.0 3.9e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EFX01475.1 - 0.00055 20.9 0.0 0.0012 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX01475.1 - 0.0078 15.8 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DUF3419 PF11899.8 EFX01475.1 - 0.023 13.9 0.0 0.85 8.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3419) DHOase PF12890.7 EFX01475.1 - 0.14 12.1 0.3 0.24 11.3 0.3 1.3 1 0 0 1 1 1 0 Dihydro-orotase-like Acetyltransf_1 PF00583.25 EFX01476.1 - 1.6e-12 47.7 0.0 2.2e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX01476.1 - 7.5e-10 38.8 0.0 1.1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX01476.1 - 2.5e-09 37.4 0.0 3.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX01476.1 - 2.1e-05 24.4 0.0 3.1e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFX01476.1 - 0.0063 16.7 0.1 0.017 15.2 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFX01476.1 - 0.0079 16.3 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF5643 PF18705.1 EFX01476.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5643) Polyketide_cyc PF03364.20 EFX01477.1 - 3.2e-24 85.6 0.0 1e-23 84.0 0.0 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport His_Phos_1 PF00300.22 EFX01479.1 - 1.3e-15 57.7 0.0 4.3e-15 55.9 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.18 EFX01481.1 - 5.3e-58 196.0 0.0 7.1e-58 195.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFX01481.1 - 5.4e-20 71.9 0.1 1.2e-19 70.7 0.1 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFX01481.1 - 0.099 12.8 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNase_H2-Ydr279 PF09468.10 EFX01482.1 - 4.6e-45 153.7 0.0 7.5e-45 153.0 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EFX01482.1 - 4.8e-23 81.2 0.0 1e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain SVIP PF15811.5 EFX01482.1 - 0.081 13.4 4.9 0.18 12.3 4.9 1.5 1 0 0 1 1 1 0 Small VCP/p97-interacting protein Transferase PF02458.15 EFX01483.1 - 0.038 12.6 0.0 0.044 12.4 0.0 1.0 1 0 0 1 1 1 0 Transferase family MFS_1 PF07690.16 EFX01484.1 - 7.9e-30 104.0 31.5 1.1e-29 103.5 31.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily NIF PF03031.18 EFX01485.1 - 4.8e-36 123.9 0.0 6.8e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Syntaphilin PF15290.6 EFX01486.1 - 3.1 7.3 9.8 4.6 6.8 9.8 1.1 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp SMC_N PF02463.19 EFX01487.1 - 8.5e-48 162.7 44.2 3.1e-31 108.5 0.7 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AA_kinase PF00696.28 EFX01487.1 - 1.9e-35 122.6 2.4 4.5e-35 121.4 0.1 2.8 2 0 0 2 2 2 1 Amino acid kinase family SMC_hinge PF06470.13 EFX01487.1 - 4.8e-25 88.1 0.0 3.1e-24 85.5 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain ACT PF01842.25 EFX01487.1 - 3.5e-13 49.1 1.4 6.6e-07 29.0 0.1 3.1 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 EFX01487.1 - 2.4e-12 46.4 5.3 1.2e-08 34.6 0.3 3.1 3 0 0 3 3 3 2 ACT domain AAA_23 PF13476.6 EFX01487.1 - 2.7e-12 47.6 10.3 2.7e-12 47.6 10.3 6.6 2 2 3 5 5 2 1 AAA domain AAA_21 PF13304.6 EFX01487.1 - 2.7e-09 37.3 11.3 7.9e-05 22.6 0.0 3.8 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFX01487.1 - 1.5e-08 34.8 2.5 1.5e-08 34.8 2.5 4.2 2 2 2 4 4 3 1 AAA ATPase domain AAA_29 PF13555.6 EFX01487.1 - 1.2e-07 31.3 0.0 2.7e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 EFX01487.1 - 0.024 14.9 0.0 0.14 12.5 0.0 2.3 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF948 PF06103.11 EFX01487.1 - 1.7 9.0 37.1 0.15 12.4 1.5 7.4 6 2 1 8 8 7 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 EFX01487.1 - 4.2 7.4 65.6 0.012 15.6 7.7 7.6 6 2 1 7 7 7 0 Laminin Domain II MRP-L20 PF12824.7 EFX01488.1 - 1.3e-52 178.3 3.1 1.8e-52 177.8 3.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 EFX01488.1 - 0.0061 16.6 0.7 0.0078 16.2 0.1 1.5 2 0 0 2 2 2 1 Neugrin IMUP PF15761.5 EFX01488.1 - 1.6 9.4 6.6 16 6.2 0.3 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein ABC_membrane PF00664.23 EFX01489.1 - 3.5e-51 174.5 10.4 4.7e-51 174.0 10.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFX01489.1 - 2.8e-33 115.3 0.0 3.9e-32 111.6 0.0 2.5 2 0 0 2 2 2 1 ABC transporter CTD_bind PF04818.13 EFX01489.1 - 1e-19 71.1 0.1 2.8e-19 69.7 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. SMC_N PF02463.19 EFX01489.1 - 2.3e-05 24.0 0.1 0.00066 19.2 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFX01489.1 - 0.00095 19.5 0.1 0.0084 16.4 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX01489.1 - 0.0019 18.6 0.0 0.013 15.9 0.0 2.5 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFX01489.1 - 0.012 16.1 0.0 0.062 13.7 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EFX01489.1 - 0.016 15.0 0.2 0.59 9.8 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_29 PF13555.6 EFX01489.1 - 0.026 14.2 0.1 0.062 13.1 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EFX01489.1 - 0.051 13.6 0.1 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF4164 PF13747.6 EFX01489.1 - 0.064 13.5 2.3 4.8 7.5 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) CREPT PF16566.5 EFX01489.1 - 0.11 12.7 0.3 0.26 11.4 0.3 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour CTK3 PF12243.8 EFX01489.1 - 0.19 11.7 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 AAA_28 PF13521.6 EFX01489.1 - 1.9 8.7 7.2 3.3 7.9 0.3 3.2 3 1 1 4 4 4 0 AAA domain HSBP1 PF06825.12 EFX01490.1 - 1.9e-17 62.8 0.6 2.3e-17 62.6 0.6 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 SF-assemblin PF06705.11 EFX01490.1 - 0.025 13.9 0.1 0.028 13.8 0.1 1.0 1 0 0 1 1 1 0 SF-assemblin/beta giardin Apolipoprotein PF01442.18 EFX01490.1 - 0.031 14.2 0.1 0.037 13.9 0.1 1.0 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EFX01490.1 - 0.035 14.1 0.2 0.043 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ANAPC4 PF12896.7 EFX01490.1 - 0.035 13.6 0.1 0.039 13.4 0.1 1.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 Baculo_PEP_C PF04513.12 EFX01490.1 - 0.037 14.1 0.2 0.043 13.9 0.2 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CLZ PF16526.5 EFX01490.1 - 0.048 14.0 0.0 0.055 13.8 0.0 1.1 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels zf-C2H2_2 PF12756.7 EFX01491.1 - 1.2e-30 105.8 17.7 9.9e-28 96.4 0.2 3.7 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFX01491.1 - 1.1e-12 47.9 13.7 2.3e-07 30.9 3.3 3.8 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX01491.1 - 1.1e-07 31.9 10.1 3.7e-07 30.3 2.4 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EFX01491.1 - 3.7e-05 24.2 12.1 0.23 12.4 0.3 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EFX01491.1 - 0.00068 20.0 16.2 0.099 13.1 0.4 4.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type DUF629 PF04780.12 EFX01491.1 - 1.8 7.0 4.3 6.8 5.1 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-DBF PF07535.12 EFX01491.1 - 2 8.6 15.0 0.12 12.5 1.9 3.7 3 0 0 3 3 3 0 DBF zinc finger Atx10homo_assoc PF09759.9 EFX01492.1 - 2.7e-11 43.3 0.0 7.1e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain RTBV_P12 PF06361.11 EFX01492.1 - 0.62 10.5 3.2 1.7 9.1 1.6 2.6 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein SDA1 PF05285.12 EFX01492.1 - 1.1 8.6 33.0 0.064 12.7 25.7 2.2 2 0 0 2 2 2 0 SDA1 Utp13 PF08625.11 EFX01493.1 - 1.8e-44 151.1 0.1 3e-44 150.4 0.1 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 EFX01493.1 - 3.7e-38 128.8 25.3 9.4e-05 23.1 0.1 12.0 11 2 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01493.1 - 8.2e-09 35.7 3.2 0.97 9.8 0.1 7.3 6 1 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX01493.1 - 0.00065 18.5 2.0 0.45 9.1 0.0 4.3 5 0 0 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFX01493.1 - 0.0081 15.0 0.0 1.4 7.6 0.0 3.2 3 0 0 3 3 3 2 Nup133 N terminal like PALB2_WD40 PF16756.5 EFX01493.1 - 0.61 9.0 5.7 14 4.5 0.3 3.9 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain AbiJ_NTD3 PF18860.1 EFX01495.1 - 0.058 12.9 0.9 2.1 7.8 0.8 2.4 2 0 0 2 2 2 0 AbiJ N-terminal domain 3 HET PF06985.11 EFX01496.1 - 1.8e-11 44.6 4.7 1e-10 42.2 0.7 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) BBE PF08031.12 EFX01497.1 - 6.4e-05 23.0 0.1 0.00012 22.1 0.1 1.4 1 0 0 1 1 1 1 Berberine and berberine like PAM2 PF07145.15 EFX01497.1 - 0.17 11.7 0.9 1.6 8.6 0.2 2.7 2 0 0 2 2 2 0 Ataxin-2 C-terminal region GCP_N_terminal PF17681.1 EFX01498.1 - 2.4e-60 204.7 0.0 6.9e-60 203.3 0.0 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFX01498.1 - 1.6e-58 198.6 0.1 2.8e-58 197.8 0.1 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Kinesin PF00225.23 EFX01499.1 - 1.3e-109 366.2 0.4 2.4e-109 365.3 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Kinesin_assoc PF16183.5 EFX01499.1 - 3.6e-35 121.7 16.2 3.5e-30 105.5 0.1 3.9 2 1 1 3 3 3 2 Kinesin-associated Microtub_bd PF16796.5 EFX01499.1 - 3.3e-23 82.3 0.0 7.9e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding DUF3694 PF12473.8 EFX01499.1 - 2.7e-16 60.6 0.0 2.7e-14 54.1 0.0 3.2 2 2 0 2 2 2 1 Kinesin protein PH PF00169.29 EFX01499.1 - 0.00024 21.6 0.1 1.1 9.8 0.0 3.1 3 0 0 3 3 3 2 PH domain KIF1B PF12423.8 EFX01499.1 - 0.00028 21.3 0.9 0.0014 19.0 0.9 2.4 1 0 0 1 1 1 1 Kinesin protein 1B Exonuc_VII_L PF02601.15 EFX01499.1 - 1.5 8.3 11.6 2.3 7.7 9.4 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit CASP_C PF08172.12 EFX01500.1 - 5.1e-93 311.0 0.1 1.3e-90 303.1 0.0 2.5 2 0 0 2 2 2 1 CASP C terminal SKA1 PF07160.12 EFX01500.1 - 0.00022 21.2 3.8 0.82 9.5 0.4 3.4 3 0 0 3 3 3 1 Spindle and kinetochore-associated protein 1 Frigida PF07899.11 EFX01500.1 - 0.0073 15.6 4.7 0.043 13.1 1.1 2.3 2 0 0 2 2 2 1 Frigida-like protein Fib_alpha PF08702.10 EFX01500.1 - 0.081 13.1 15.0 1.3 9.2 5.1 3.7 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family LemA PF04011.12 EFX01500.1 - 0.21 11.5 5.2 0.1 12.4 0.8 2.6 2 0 0 2 2 2 0 LemA family CC2-LZ PF16516.5 EFX01500.1 - 0.25 11.7 19.6 0.72 10.3 0.8 4.2 4 1 0 4 4 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ADIP PF11559.8 EFX01500.1 - 0.25 11.4 37.4 0.56 10.3 1.3 5.3 6 1 0 6 6 5 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 EFX01500.1 - 0.31 11.1 16.1 3.6 7.6 1.4 4.5 3 2 0 3 3 3 0 Protein of unknown function (DUF1664) Virulence_fact PF13769.6 EFX01500.1 - 0.56 10.5 4.0 1.3 9.3 1.6 2.7 2 0 0 2 2 2 0 Virulence factor SlyX PF04102.12 EFX01500.1 - 0.58 10.8 0.0 0.58 10.8 0.0 5.5 6 0 0 6 6 5 0 SlyX TolA_bind_tri PF16331.5 EFX01500.1 - 0.67 10.1 27.7 1.3 9.2 1.0 5.4 6 0 0 6 6 5 0 TolA binding protein trimerisation LRS4 PF10422.9 EFX01500.1 - 1.7 8.1 13.3 0.027 14.0 5.0 2.0 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 NUDE_C PF04880.13 EFX01500.1 - 3.3 8.2 16.2 0.52 10.8 1.6 3.6 3 1 1 4 4 4 0 NUDE protein, C-terminal conserved region XkdW PF09636.10 EFX01500.1 - 4.6 7.4 6.3 1.3 9.1 1.0 2.8 2 0 0 2 2 2 0 XkdW protein AAA_13 PF13166.6 EFX01500.1 - 5.4 5.5 15.0 1.9 7.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATG16 PF08614.11 EFX01500.1 - 5.5 7.2 51.1 1.2 9.3 0.5 5.9 4 2 0 5 5 5 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EFX01500.1 - 5.8 6.9 40.2 1.7 8.6 1.6 5.4 3 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-ZPR1 PF03367.13 EFX01500.1 - 6.1 6.7 6.9 1.8 8.4 0.2 2.7 2 0 0 2 2 2 0 ZPR1 zinc-finger domain DUF5082 PF16888.5 EFX01500.1 - 7.2 6.9 21.7 0.98 9.7 0.2 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF5082) Fez1 PF06818.15 EFX01500.1 - 7.4 7.0 26.0 9.8 6.6 2.4 4.0 2 1 0 3 3 3 0 Fez1 Cep57_MT_bd PF06657.13 EFX01500.1 - 7.4 7.1 23.1 0.88 10.1 2.1 4.6 5 0 0 5 5 5 0 Centrosome microtubule-binding domain of Cep57 adh_short PF00106.25 EFX01501.1 - 1.7e-22 79.8 0.1 1.3e-17 63.9 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EFX01501.1 - 2.2e-12 47.3 0.3 4.1e-12 46.4 0.3 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EFX01501.1 - 2.9e-12 46.6 0.7 1.3e-08 34.7 0.2 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Abhydrolase_2 PF02230.16 EFX01501.1 - 1.1e-08 35.1 0.0 1.9e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Shikimate_DH PF01488.20 EFX01501.1 - 0.0034 17.4 0.0 0.006 16.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EFX01501.1 - 0.015 14.8 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 EFX01501.1 - 0.13 12.2 0.7 0.76 9.7 0.0 2.4 2 0 0 2 2 2 0 YjeF-related protein N-terminus Sacchrp_dh_NADP PF03435.18 EFX01501.1 - 0.23 11.7 0.7 1.2 9.4 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain adh_short_C2 PF13561.6 EFX01502.1 - 9.5e-61 205.3 0.9 1.1e-60 205.1 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01502.1 - 4.1e-39 134.1 1.0 5e-39 133.8 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01502.1 - 8.3e-17 61.7 0.5 1.2e-16 61.2 0.5 1.2 1 0 0 1 1 1 1 KR domain Glyco_hydro_99 PF16317.5 EFX01502.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 99 zf-C2H2 PF00096.26 EFX01503.1 - 3.7e-06 27.1 14.6 0.12 12.9 1.2 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EFX01503.1 - 0.029 14.5 2.1 1.7 8.7 0.1 2.2 1 1 1 2 2 2 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EFX01503.1 - 0.15 13.0 12.7 11 7.2 2.7 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger PT-VENN PF04829.13 EFX01503.1 - 3.1 8.0 8.2 10 6.3 0.5 3.4 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif adh_short_C2 PF13561.6 EFX01504.1 - 4.7e-33 114.7 0.2 1.9e-32 112.7 0.2 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01504.1 - 7.7e-33 113.6 0.1 1.5e-32 112.7 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01504.1 - 3e-07 30.5 1.3 4e-06 26.8 0.1 2.1 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EFX01504.1 - 0.16 11.4 0.2 4.8 6.6 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF572 PF04502.13 EFX01505.1 - 2.4e-65 221.3 7.0 2.9e-65 221.1 7.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) zinc_ribbon_4 PF13717.6 EFX01505.1 - 0.16 12.0 0.8 13 5.8 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-CSL PF05207.13 EFX01505.1 - 0.23 11.2 1.3 0.61 9.9 1.3 1.7 1 1 0 1 1 1 0 CSL zinc finger zf-ACC PF17848.1 EFX01505.1 - 0.41 10.8 1.5 6.8 6.9 0.4 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF951 PF06107.11 EFX01505.1 - 2 8.4 4.0 20 5.2 0.1 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF951) Methyltransf_16 PF10294.9 EFX01506.1 - 0.1 12.3 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase DUF1465 PF07323.12 EFX01506.1 - 0.17 11.7 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) RAMP4 PF06624.12 EFX01507.1 - 1.2e-22 79.7 0.2 1.3e-22 79.6 0.2 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF5542 PF17696.1 EFX01507.1 - 0.12 12.5 0.7 0.22 11.7 0.7 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5542) YqzE PF14038.6 EFX01507.1 - 0.17 11.9 1.1 1.1 9.3 1.1 2.0 1 1 0 1 1 1 0 YqzE-like protein EF1G PF00647.19 EFX01508.1 - 3.3e-43 146.1 0.1 7e-43 145.0 0.1 1.6 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EFX01508.1 - 8.1e-15 54.8 0.1 8.1e-15 54.8 0.1 2.4 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFX01508.1 - 2.8e-14 53.2 0.0 9e-14 51.6 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFX01508.1 - 4.1e-10 39.9 0.0 8.9e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFX01508.1 - 1.9e-08 34.2 3.1 5.4e-08 32.7 0.3 2.7 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFX01508.1 - 7e-07 29.5 0.0 2e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFX01508.1 - 8.2e-05 22.7 0.1 0.00033 20.8 0.1 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_60s PF00428.19 EFX01508.1 - 0.0084 16.7 8.0 0.019 15.5 8.0 1.6 1 0 0 1 1 1 1 60s Acidic ribosomal protein ketoacyl-synt PF00109.26 EFX01509.1 - 1e-06 28.5 0.0 1.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Methyltransf_8 PF05148.15 EFX01510.1 - 1.8e-52 178.4 0.0 4.3e-51 173.9 0.0 2.8 2 1 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EFX01510.1 - 1.6e-07 31.8 0.0 6.1e-07 30.0 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX01510.1 - 2.1e-05 25.2 0.1 0.00015 22.4 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX01510.1 - 0.026 14.1 1.5 0.98 8.9 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EFX01510.1 - 0.03 14.3 0.0 0.03 14.3 0.0 3.2 2 1 0 2 2 2 0 Methyltransferase domain TFIIA PF03153.13 EFX01510.1 - 6.3 6.7 38.4 9.1 6.2 38.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fungal_trans PF04082.18 EFX01511.1 - 4.8e-16 58.6 0.0 1.3e-15 57.2 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01511.1 - 4.1e-11 42.8 8.9 7e-11 42.1 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dynamin_N PF00350.23 EFX01512.1 - 9.8e-45 152.6 0.0 1.7e-44 151.9 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFX01512.1 - 9e-12 44.8 0.0 6.1e-10 38.8 0.0 2.4 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EFX01512.1 - 3e-05 24.1 0.0 0.00018 21.5 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EFX01512.1 - 0.072 12.9 0.0 0.072 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFX01512.1 - 0.093 12.4 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 EFX01512.1 - 0.17 12.3 0.0 0.17 12.3 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain AAA_29 PF13555.6 EFX01512.1 - 1.7 8.5 3.3 2.5 7.9 0.2 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Fructosamin_kin PF03881.14 EFX01513.1 - 0.042 13.0 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Fructosamine kinase APH PF01636.23 EFX01513.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2838 PF10998.8 EFX01514.1 - 6.6e-46 155.1 8.0 6.6e-46 155.1 8.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) DUF3584 PF12128.8 EFX01514.1 - 0.28 8.7 2.9 0.38 8.2 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Cyclin_N PF00134.23 EFX01515.1 - 3e-44 149.8 0.0 7.9e-43 145.2 0.0 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFX01515.1 - 4.2e-35 120.4 0.1 4.2e-35 120.4 0.1 2.0 2 1 0 2 2 2 1 Cyclin, C-terminal domain SET PF00856.28 EFX01515.1 - 0.088 13.2 4.4 0.21 12.0 4.0 1.7 1 1 0 1 1 1 0 SET domain Peptidase_S46 PF10459.9 EFX01515.1 - 7.3 5.1 20.6 9.7 4.7 20.6 1.1 1 0 0 1 1 1 0 Peptidase S46 Peptidase_C12 PF01088.21 EFX01516.1 - 4.2e-62 209.6 0.0 5.9e-62 209.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EFX01516.1 - 1.4e-09 37.7 0.1 1.4e-09 37.7 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases adh_short_C2 PF13561.6 EFX01517.1 - 1.7e-42 145.6 4.4 2e-42 145.4 4.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01517.1 - 5.8e-39 133.6 0.7 7.1e-39 133.3 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01517.1 - 2.4e-11 43.9 2.5 4.4e-11 43.0 2.5 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX01517.1 - 0.0039 16.7 0.4 0.033 13.7 0.1 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family SPOR PF05036.13 EFX01517.1 - 0.069 13.5 0.6 0.39 11.1 0.1 2.3 2 1 1 3 3 3 0 Sporulation related domain PDDEXK_9 PF08011.11 EFX01517.1 - 0.12 12.3 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily CN_hydrolase PF00795.22 EFX01518.1 - 1.6e-56 191.6 0.0 1.9e-56 191.3 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sugar_tr PF00083.24 EFX01519.1 - 1.2e-89 301.2 25.8 1.5e-89 300.9 25.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX01519.1 - 1.8e-29 102.8 50.1 6.3e-28 97.7 25.6 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX01519.1 - 3.4e-05 22.5 3.4 3.4e-05 22.5 3.4 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EFX01519.1 - 1.9 7.3 23.2 0.3 9.9 9.6 2.6 2 1 1 3 3 3 0 MFS_1 like family Peptidase_M24 PF00557.24 EFX01520.1 - 2.8e-47 161.1 0.0 4e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFX01520.1 - 9.3e-32 109.4 0.0 1.6e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain AA_permease PF00324.21 EFX01522.1 - 9.3e-147 489.5 35.1 1.1e-146 489.2 35.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX01522.1 - 1.4e-36 126.3 37.9 1.7e-36 126.0 37.9 1.1 1 0 0 1 1 1 1 Amino acid permease Prefoldin_2 PF01920.20 EFX01523.1 - 2e-19 69.5 2.2 2.4e-19 69.3 2.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Phage_GP20 PF06810.11 EFX01523.1 - 0.016 15.0 0.7 0.026 14.3 0.7 1.4 1 1 0 1 1 1 0 Phage minor structural protein GP20 TMF_TATA_bd PF12325.8 EFX01523.1 - 0.025 14.8 2.9 0.75 10.0 0.0 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Val_tRNA-synt_C PF10458.9 EFX01523.1 - 0.057 13.7 1.3 0.091 13.1 0.1 2.1 2 1 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm XhlA PF10779.9 EFX01523.1 - 0.13 12.5 1.6 0.97 9.7 0.1 2.1 2 0 0 2 2 2 0 Haemolysin XhlA Leu_zip PF15294.6 EFX01523.1 - 0.26 10.8 4.6 4.4 6.7 1.6 2.0 1 1 1 2 2 2 0 Leucine zipper Cortex-I_coil PF09304.10 EFX01523.1 - 0.27 11.5 3.5 4.1 7.7 1.2 2.2 1 1 1 2 2 2 0 Cortexillin I, coiled coil UvdE PF03851.14 EFX01524.1 - 2.3e-100 335.4 0.0 5.7e-100 334.1 0.0 1.6 1 1 0 1 1 1 1 UV-endonuclease UvdE Peptidase_C24 PF03510.14 EFX01524.1 - 0.28 11.7 0.8 0.57 10.7 0.8 1.4 1 0 0 1 1 1 0 2C endopeptidase (C24) cysteine protease family DUF3439 PF11921.8 EFX01524.1 - 1.1 9.2 6.6 2.1 8.3 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FAD_binding_3 PF01494.19 EFX01526.1 - 2.6e-10 40.1 0.3 6e-10 38.9 0.3 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX01526.1 - 3e-06 26.7 0.2 0.00082 18.7 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX01526.1 - 8.1e-06 25.3 0.1 0.00099 18.4 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX01526.1 - 1.1e-05 25.5 0.8 2.3e-05 24.6 0.8 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX01526.1 - 9.8e-05 22.1 2.0 9.8e-05 22.1 2.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX01526.1 - 0.0001 21.5 2.1 0.0002 20.6 2.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFX01526.1 - 0.0012 19.3 0.7 0.0042 17.6 0.6 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX01526.1 - 0.014 14.1 2.0 0.033 12.9 0.6 1.9 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EFX01526.1 - 0.014 14.6 0.4 0.027 13.7 0.4 1.5 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 EFX01526.1 - 0.023 14.3 0.2 0.05 13.2 0.2 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 EFX01526.1 - 0.049 12.7 1.3 0.13 11.3 0.6 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFX01526.1 - 0.05 12.9 0.8 0.088 12.1 0.8 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX01526.1 - 0.22 11.5 3.9 4.9 7.1 0.3 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EFX01526.1 - 0.33 10.2 2.2 0.54 9.5 0.2 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EFX01526.1 - 0.41 9.6 5.0 2.1 7.3 0.4 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein PI3_PI4_kinase PF00454.27 EFX01527.1 - 1.5e-40 139.6 0.0 3.2e-40 138.5 0.0 1.6 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase N2227 PF07942.12 EFX01528.1 - 2.5e-92 308.9 0.0 4.6e-91 304.8 0.0 2.0 1 1 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EFX01528.1 - 0.00035 20.5 0.0 0.00058 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01528.1 - 0.0012 19.4 0.0 0.0037 17.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01528.1 - 0.0097 16.6 0.0 0.025 15.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX01528.1 - 0.038 14.7 0.1 0.12 13.1 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain HET PF06985.11 EFX01529.1 - 1.5e-22 80.5 0.0 2.6e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SNARE PF05739.19 EFX01530.1 - 3.2e-15 55.8 2.9 4e-15 55.5 0.6 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EFX01530.1 - 1.8e-05 24.5 7.8 3.8e-05 23.5 7.8 1.5 1 1 0 1 1 1 1 Syntaxin DUF4407 PF14362.6 EFX01530.1 - 0.038 13.3 5.8 0.083 12.2 5.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DLH PF01738.18 EFX01531.1 - 0.13 11.8 0.0 7.7 6.0 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family MFS_1 PF07690.16 EFX01532.1 - 1e-36 126.6 35.0 1e-36 126.6 35.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX01532.1 - 2.6e-06 26.1 1.4 4.6e-06 25.4 1.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UCR_14kD PF02271.16 EFX01533.1 - 9.4e-43 144.3 0.2 1.1e-42 144.1 0.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Transketolase_N PF00456.21 EFX01534.1 - 7.1e-159 528.2 0.1 9.1e-159 527.8 0.1 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EFX01534.1 - 9.4e-45 152.5 0.0 1.5e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFX01534.1 - 5.9e-11 42.3 0.0 1.3e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EFX01534.1 - 0.00011 21.6 0.0 0.00036 19.8 0.0 1.7 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF4335 PF14233.6 EFX01535.1 - 0.053 13.4 0.2 0.44 10.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4335) Nitroreductase PF00881.24 EFX01536.1 - 2.5e-16 60.2 0.0 3e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family HNH_2 PF13391.6 EFX01537.1 - 7.2e-07 29.2 0.0 1.5e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease DUF4428 PF14471.6 EFX01538.1 - 0.073 13.0 0.0 42 4.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) RskA PF10099.9 EFX01538.1 - 0.13 12.5 7.8 0.4 10.9 2.0 2.7 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF218 PF02698.17 EFX01539.1 - 5.1e-05 23.3 0.1 0.00014 21.9 0.1 1.7 1 1 0 1 1 1 1 DUF218 domain Trehalose_PPase PF02358.16 EFX01539.1 - 0.11 11.6 0.0 0.2 10.8 0.0 1.4 2 0 0 2 2 2 0 Trehalose-phosphatase A_deaminase PF00962.22 EFX01540.1 - 2.5e-119 398.5 0.1 3.7e-119 397.9 0.1 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase PQ-loop PF04193.14 EFX01541.1 - 1e-31 108.5 7.3 1.2e-15 57.1 0.6 2.5 2 0 0 2 2 2 2 PQ loop repeat GTP_EFTU PF00009.27 EFX01542.1 - 1.4e-56 191.1 0.2 1.8e-56 190.8 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFX01542.1 - 4.2e-26 91.4 0.0 9.5e-26 90.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFX01542.1 - 5.2e-16 58.8 2.9 5.2e-16 58.8 2.9 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFX01542.1 - 2.1e-05 24.6 0.1 4.2e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFX01542.1 - 0.00068 19.6 0.1 0.0018 18.2 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 EFX01542.1 - 0.019 14.5 0.2 0.12 12.0 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EFX01542.1 - 0.07 12.9 0.2 16 5.3 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TPR_11 PF13414.6 EFX01543.1 - 5e-12 45.3 0.0 0.00011 21.8 0.1 3.8 3 1 1 4 4 4 3 TPR repeat TPR_2 PF07719.17 EFX01543.1 - 8.9e-11 41.1 0.0 0.00013 21.8 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX01543.1 - 7.4e-09 35.7 9.0 0.00067 20.3 0.4 5.3 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFX01543.1 - 3.3e-08 33.9 1.9 0.021 15.3 0.1 4.3 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX01543.1 - 4.8e-07 30.0 0.1 0.005 17.1 0.1 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01543.1 - 1.1e-05 26.0 10.9 0.00039 21.0 1.8 3.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX01543.1 - 1.6e-05 24.5 0.0 0.021 14.6 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX01543.1 - 7.1e-05 22.7 0.0 1.5 9.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFX01543.1 - 0.00029 21.0 0.0 0.047 14.1 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX01543.1 - 0.00032 21.1 0.1 4 8.3 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFX01543.1 - 0.0011 19.1 0.8 0.022 14.9 0.9 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 EFX01543.1 - 0.0093 16.3 0.7 0.13 12.6 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 EFX01543.1 - 0.015 15.7 0.1 0.046 14.2 0.1 2.0 1 1 0 1 1 1 0 Bacterial transcriptional activator domain Orbi_VP5 PF00901.17 EFX01543.1 - 0.021 13.2 0.0 0.03 12.7 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 zf-C2H2 PF00096.26 EFX01544.1 - 1.1e-09 38.2 9.6 7.3e-05 23.0 3.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type Fungal_trans PF04082.18 EFX01544.1 - 7.2e-08 31.8 0.1 1.4e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01544.1 - 4.5e-06 26.7 8.2 1.1e-05 25.4 8.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EFX01544.1 - 0.00057 20.5 0.3 0.00057 20.5 0.3 3.3 4 0 0 4 4 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX01544.1 - 0.00093 19.5 2.0 0.00093 19.5 2.0 4.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EFX01544.1 - 0.003 17.8 2.3 1.1 9.6 0.0 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EFX01544.1 - 0.0057 16.9 7.5 0.012 15.9 2.8 2.4 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 EFX01544.1 - 0.0069 16.3 4.1 0.0071 16.2 0.7 2.7 2 0 0 2 2 2 1 zinc-finger of a C2HC-type Zn-C2H2_12 PF18112.1 EFX01544.1 - 0.0069 16.8 0.1 0.022 15.2 0.1 1.9 1 0 0 1 1 1 1 Autophagy receptor zinc finger-C2H2 domain SUIM_assoc PF16619.5 EFX01544.1 - 0.019 15.0 2.2 0.019 15.0 2.2 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 EFX01544.1 - 1.4 8.4 9.5 2.4 7.7 9.5 1.3 1 0 0 1 1 1 0 Spt20 family IBR PF01485.21 EFX01544.1 - 2.5 8.4 9.2 11 6.3 9.2 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain p450 PF00067.22 EFX01545.1 - 1.1e-40 139.8 0.0 7.1e-40 137.1 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 EFX01546.1 - 1.4e-08 34.7 12.5 2e-08 34.2 12.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.13 EFX01547.1 - 2.1e-38 132.5 0.2 2.1e-38 132.5 0.2 2.6 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3584 PF12128.8 EFX01547.1 - 0.00067 17.3 7.4 0.00085 17.0 7.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) CR6_interact PF10147.9 EFX01547.1 - 0.0037 17.0 0.1 0.0053 16.5 0.1 1.2 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF1043 PF06295.12 EFX01547.1 - 0.015 15.3 0.3 0.026 14.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) CALCOCO1 PF07888.11 EFX01547.1 - 0.032 13.1 6.4 0.045 12.6 6.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Golgin_A5 PF09787.9 EFX01547.1 - 0.088 12.3 2.3 0.13 11.8 2.3 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Spc7 PF08317.11 EFX01547.1 - 0.1 11.4 2.1 0.16 10.8 2.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EFX01547.1 - 0.11 12.5 3.3 3.2 7.8 0.1 2.1 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF848 PF05852.11 EFX01547.1 - 0.12 12.5 1.7 0.19 11.8 1.7 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) FUSC PF04632.12 EFX01547.1 - 0.15 10.6 3.1 0.21 10.1 3.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family BST2 PF16716.5 EFX01547.1 - 0.26 11.9 3.6 0.53 10.9 3.6 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Apolipoprotein PF01442.18 EFX01547.1 - 4.1 7.2 13.5 23 4.8 12.2 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain RPN7 PF10602.9 EFX01548.1 - 6.2e-53 179.1 0.1 3.4e-52 176.7 0.0 2.1 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 EFX01548.1 - 5.6e-15 55.7 0.0 1e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 PCI domain Herpes_capsid PF06112.11 EFX01548.1 - 8.7 6.4 19.6 0.2 11.7 7.9 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Ig_GlcNase PF18368.1 EFX01549.1 - 1.2e-30 105.8 0.7 1.3e-29 102.4 0.0 2.9 3 0 0 3 3 3 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 EFX01549.1 - 1.3e-08 35.4 0.0 3.4e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 EFX01549.1 - 0.00064 19.4 0.0 0.002 17.8 0.0 1.9 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2_N PF02837.18 EFX01549.1 - 0.029 14.3 0.0 0.066 13.1 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain DNA_pol_B_thumb PF14791.6 EFX01550.1 - 1.9e-21 76.0 0.0 3.9e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EFX01550.1 - 3.2e-18 65.3 0.2 8.5e-18 63.9 0.2 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 EFX01550.1 - 1.8e-15 57.1 0.0 6e-14 52.2 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase beta palm HHH_8 PF14716.6 EFX01550.1 - 1.9e-13 50.6 0.0 4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 EFX01550.1 - 0.045 14.4 0.0 17 6.1 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain GTP_CH_N PF12471.8 EFX01551.1 - 1.4e-89 299.0 0.0 2e-89 298.5 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EFX01551.1 - 9.8e-14 51.3 0.0 3.7e-13 49.4 0.0 1.8 2 0 0 2 2 2 1 GTP cyclohydrolase II MBOAT PF03062.19 EFX01552.1 - 2.2e-38 132.5 14.2 2.8e-37 128.9 9.7 2.1 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EFX01552.1 - 0.023 15.0 1.3 0.08 13.2 1.3 1.9 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family MTHFR PF02219.17 EFX01553.1 - 2.2e-97 325.9 0.0 3.3e-97 325.3 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase NCBP3 PF10309.9 EFX01554.1 - 4.9e-19 67.9 0.0 8e-19 67.2 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Cpn60_TCP1 PF00118.24 EFX01555.1 - 2.3e-156 521.3 2.8 2.6e-156 521.1 2.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.16 EFX01555.1 - 0.13 12.4 0.4 13 6.0 0.0 3.0 3 0 0 3 3 3 0 Enolase, N-terminal domain SelR PF01641.18 EFX01556.1 - 2.2e-43 147.2 0.1 3.3e-43 146.6 0.1 1.3 1 1 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 EFX01556.1 - 0.069 12.9 0.1 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 EFX01556.1 - 0.13 12.5 0.3 0.28 11.4 0.3 1.6 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Trehalase PF01204.18 EFX01557.1 - 1.5e-198 660.8 0.0 1.8e-198 660.6 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EFX01557.1 - 2.5e-17 62.3 0.5 4.1e-17 61.6 0.5 1.3 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain HATPase_c_2 PF13581.6 EFX01557.1 - 0.096 12.7 0.0 0.61 10.0 0.0 2.3 1 1 1 2 2 2 0 Histidine kinase-like ATPase domain Goodbye PF17109.5 EFX01558.1 - 6.6e-35 120.2 0.0 2.6e-34 118.3 0.0 2.2 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain TPR_12 PF13424.6 EFX01558.1 - 1.6e-07 31.5 1.6 2.1e-06 27.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX01558.1 - 1.7e-05 24.6 0.1 0.29 11.4 0.2 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFX01558.1 - 1.9e-05 24.5 0.1 0.12 12.6 0.0 3.9 3 0 0 3 3 2 2 Tetratricopeptide repeat AAA_16 PF13191.6 EFX01558.1 - 0.0022 18.4 0.1 0.013 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain TPR_MalT PF17874.1 EFX01558.1 - 0.0038 16.6 0.0 0.014 14.7 0.0 2.0 1 0 0 1 1 1 1 MalT-like TPR region TPR_14 PF13428.6 EFX01558.1 - 0.014 16.2 5.3 68 4.7 0.1 6.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01558.1 - 0.044 14.4 0.6 0.044 14.4 0.6 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA_22 PF13401.6 EFX01558.1 - 0.051 13.9 0.0 0.5 10.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain TPR_19 PF14559.6 EFX01558.1 - 0.057 13.9 6.5 4.7 7.8 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFX01558.1 - 0.065 13.1 1.2 3.1 7.8 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1848 PF08902.11 EFX01558.1 - 0.35 10.6 0.0 0.35 10.6 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1848) AMP-binding PF00501.28 EFX01559.1 - 1.5e-84 284.1 0.0 1.9e-84 283.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX01559.1 - 5.7e-15 56.1 0.1 1.8e-14 54.4 0.1 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EFX01559.1 - 0.00071 18.5 0.0 0.0027 16.6 0.0 1.8 2 0 0 2 2 2 1 GH3 auxin-responsive promoter Glyco_hydro_12 PF01670.16 EFX01560.1 - 1.5e-44 152.5 10.2 1.8e-44 152.3 10.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Inhibitor_I36 PF03995.13 EFX01560.1 - 0.76 9.7 10.3 0.19 11.7 3.7 2.7 2 1 0 2 2 2 0 Peptidase inhibitor family I36 DUF3716 PF12511.8 EFX01561.1 - 5e-07 29.7 5.5 8.6e-07 28.9 5.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Mem_trans PF03547.18 EFX01561.1 - 0.023 13.1 0.2 0.04 12.3 0.2 1.3 1 0 0 1 1 1 0 Membrane transport protein Cullin_binding PF03556.15 EFX01562.1 - 3.3e-29 101.8 4.2 4.2e-29 101.4 4.2 1.1 1 0 0 1 1 1 1 Cullin binding DUF2867 PF11066.8 EFX01562.1 - 0.09 13.1 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) Ribosomal_L27A PF00828.19 EFX01564.1 - 4.1e-33 114.8 0.8 9.6e-33 113.6 0.8 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RRM_1 PF00076.22 EFX01564.1 - 2.6e-08 33.6 0.0 6.2e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFX01564.1 - 0.0011 18.9 0.0 0.0053 16.7 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Alpha_Helical PF18489.1 EFX01564.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Alpha helical domain Indigoidine_A PF04227.12 EFX01566.1 - 1.1e-107 359.7 0.7 1.8e-107 359.1 0.7 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EFX01566.1 - 2.4e-24 86.2 3.9 3.9e-16 59.2 0.1 3.2 3 0 0 3 3 3 2 pfkB family carbohydrate kinase GMC_oxred_N PF00732.19 EFX01567.1 - 3.2e-53 181.0 0.0 4e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX01567.1 - 1.2e-32 113.4 0.0 1.9e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Thi4 PF01946.17 EFX01567.1 - 0.21 10.8 0.3 0.33 10.2 0.3 1.2 1 0 0 1 1 1 0 Thi4 family UQ_con PF00179.26 EFX01569.1 - 3.6e-49 166.0 0.0 4e-49 165.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX01569.1 - 0.02 14.6 0.1 0.035 13.8 0.1 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B DAO PF01266.24 EFX01570.1 - 1.6e-30 106.9 0.0 3e-23 83.0 0.0 2.1 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX01570.1 - 0.00048 19.5 0.0 0.043 13.0 0.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX01570.1 - 0.014 15.3 0.2 4.4 7.3 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.22 EFX01570.1 - 0.059 12.4 0.6 1.2 8.2 0.0 2.2 2 1 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox PF00070.27 EFX01570.1 - 0.17 12.4 0.0 5.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 2OG-FeII_Oxy PF03171.20 EFX01571.1 - 4.4e-16 59.2 0.0 8e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EFX01571.1 - 2.5e-06 28.2 0.0 6.6e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Mannitol_dh_C PF08125.13 EFX01572.1 - 2.1e-76 256.6 0.0 3.8e-76 255.8 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EFX01572.1 - 2.2e-46 157.8 0.0 3.5e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain UDPGP PF01704.18 EFX01573.1 - 3.7e-192 638.5 0.0 4.4e-192 638.3 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PilO PF04350.13 EFX01573.1 - 0.089 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Pilus assembly protein, PilO DUF4301 PF14134.6 EFX01573.1 - 0.21 10.4 1.6 3.3 6.4 0.1 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4301) ABC2_membrane PF01061.24 EFX01574.1 - 6.3e-81 270.8 50.3 2.2e-43 148.2 22.0 2.5 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EFX01574.1 - 4e-37 127.8 0.0 2.5e-17 63.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFX01574.1 - 1.7e-24 85.5 7.7 8.3e-24 83.3 0.0 3.4 3 0 0 3 3 2 1 CDR ABC transporter ABC2_membrane_3 PF12698.7 EFX01574.1 - 8.3e-07 28.4 44.2 0.0011 18.2 10.4 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EFX01574.1 - 7.8e-06 26.4 0.6 0.0061 17.0 0.2 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EFX01574.1 - 9.5e-06 25.3 0.0 0.0037 16.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFX01574.1 - 3.4e-05 23.8 0.0 0.0064 16.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase ABC_trans_N PF14510.6 EFX01574.1 - 0.00035 21.1 0.1 0.0018 18.8 0.0 2.2 3 0 0 3 3 2 1 ABC-transporter N-terminal AAA_29 PF13555.6 EFX01574.1 - 0.0015 18.3 0.1 0.092 12.5 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EFX01574.1 - 0.0018 18.6 0.1 0.39 10.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX01574.1 - 0.0025 18.1 0.3 0.9 9.8 0.2 3.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFX01574.1 - 0.013 16.0 0.0 3.5 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EFX01574.1 - 0.018 14.6 0.7 1.9 8.0 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EFX01574.1 - 0.035 13.8 0.3 7.2 6.3 0.3 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFX01574.1 - 0.047 13.9 0.1 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFX01574.1 - 0.056 13.5 0.3 13 5.9 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EFX01574.1 - 0.14 11.4 0.0 3.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin URO-D PF01208.17 EFX01575.1 - 6.2e-124 413.6 0.0 6.9e-124 413.5 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) SOR_SNZ PF01680.17 EFX01576.1 - 8.4e-96 319.7 5.0 1.1e-95 319.3 5.0 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EFX01576.1 - 3.7e-09 36.3 3.8 3.3e-06 26.6 0.1 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EFX01576.1 - 0.00043 19.5 0.7 0.4 9.7 0.3 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 EFX01576.1 - 0.00064 19.7 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain NanE PF04131.14 EFX01576.1 - 0.0017 17.6 0.5 0.056 12.6 0.0 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 EFX01576.1 - 0.006 16.1 0.9 0.36 10.2 0.1 2.9 2 1 1 3 3 3 1 Histidine biosynthesis protein IGPS PF00218.21 EFX01576.1 - 0.018 14.2 0.0 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase NMO PF03060.15 EFX01576.1 - 1.3 8.3 8.8 5.7 6.2 0.4 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase PIN_6 PF17146.4 EFX01577.1 - 3.4e-32 110.8 0.1 9.4e-32 109.4 0.1 1.8 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EFX01577.1 - 2.5e-30 104.4 3.1 4.3e-30 103.7 3.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like WRNPLPNID PF15017.6 EFX01577.1 - 0.016 16.1 10.1 0.016 16.1 10.1 2.2 1 1 1 2 2 2 0 Putative WW-binding domain and destruction box zf-NADH-PPase PF09297.11 EFX01577.1 - 0.42 10.3 5.1 0.26 11.0 1.0 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain RNA_pol_3_Rpc31 PF11705.8 EFX01577.1 - 8.8 6.5 12.2 17 5.6 12.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 MFS_1 PF07690.16 EFX01578.1 - 1.7e-49 168.7 28.0 3.8e-49 167.5 28.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX01578.1 - 4.1e-13 49.0 11.1 4.1e-13 49.0 11.1 3.0 2 2 1 3 3 3 1 Sugar (and other) transporter IDO PF01231.18 EFX01578.1 - 0.19 10.5 0.3 0.29 9.9 0.3 1.2 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase Fungal_trans PF04082.18 EFX01579.1 - 8e-25 87.4 0.0 1.2e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mito_carr PF00153.27 EFX01579.1 - 9.4e-25 86.4 0.4 1.1e-11 44.5 0.1 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Fringe PF02434.16 EFX01580.1 - 2.1e-06 27.4 0.1 8.2e-06 25.4 0.1 1.8 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 EFX01580.1 - 0.00022 21.0 0.4 0.00022 21.0 0.4 2.0 2 0 0 2 2 2 1 PAN domain Galactosyl_T PF01762.21 EFX01580.1 - 0.031 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase PAN_1 PF00024.26 EFX01580.1 - 0.087 12.8 0.0 0.087 12.8 0.0 1.6 2 0 0 2 2 2 0 PAN domain FMO-like PF00743.19 EFX01581.1 - 1.2e-08 33.9 2.1 2.8e-08 32.7 0.7 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFX01581.1 - 1.6e-08 34.6 0.2 5.9e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX01581.1 - 2.5e-06 26.9 0.0 0.00021 20.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX01581.1 - 5.2e-06 25.9 0.3 2.6e-05 23.6 0.3 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX01581.1 - 0.00012 21.3 0.0 0.00097 18.4 0.0 2.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFX01581.1 - 0.0019 18.2 0.5 0.056 13.4 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding UPF0139 PF03669.13 EFX01582.1 - 3.2e-06 26.9 0.2 4.3e-06 26.5 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) ING PF12998.7 EFX01584.1 - 6.5e-22 78.0 2.8 1e-21 77.4 2.8 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EFX01584.1 - 6.3e-05 22.8 8.4 0.00011 22.0 8.4 1.4 1 0 0 1 1 1 1 PHD-finger Rh5 PF18515.1 EFX01584.1 - 0.2 10.9 0.1 0.29 10.4 0.1 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain zf-RING_2 PF13639.6 EFX01584.1 - 1.4 9.3 6.4 2.4 8.5 6.4 1.4 1 0 0 1 1 1 0 Ring finger domain Prefoldin PF02996.17 EFX01584.1 - 1.7 8.6 3.5 1.8 8.5 1.6 1.8 2 0 0 2 2 2 0 Prefoldin subunit tRNA_int_endo PF01974.17 EFX01585.1 - 1.4e-18 66.7 0.0 3.3e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Lipase_GDSL_2 PF13472.6 EFX01585.1 - 4.8e-09 36.9 1.2 4.8e-09 36.9 1.2 2.3 3 0 0 3 3 3 1 GDSL-like Lipase/Acylhydrolase family tRNA_int_endo_N PF02778.14 EFX01585.1 - 0.0004 20.0 0.0 0.0038 16.9 0.0 2.2 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain DUF1996 PF09362.10 EFX01586.1 - 1.8e-82 276.9 0.1 2.6e-82 276.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF4703 PF15775.5 EFX01587.1 - 0.003 17.4 2.0 4.8 6.9 4.4 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4703) Lebercilin PF15619.6 EFX01587.1 - 0.025 14.3 5.5 0.033 13.8 5.5 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease HMMR_N PF15905.5 EFX01587.1 - 0.038 13.5 1.5 0.054 13.0 1.5 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal CENP-H PF05837.12 EFX01587.1 - 0.18 12.3 2.2 0.22 12.0 1.1 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Occludin_ELL PF07303.13 EFX01587.1 - 0.33 11.7 6.6 0.22 12.2 1.2 2.5 2 1 1 3 3 3 0 Occludin homology domain HIP1_clath_bdg PF16515.5 EFX01587.1 - 1 10.0 5.5 7.5 7.2 1.5 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Ferritin_2 PF13668.6 EFX01588.1 - 1.4e-14 54.5 0.0 2.2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain Ferritin-like PF12902.7 EFX01588.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Ferritin-like CRC_subunit PF08624.10 EFX01590.1 - 3e-52 176.6 0.0 5.8e-52 175.7 0.0 1.5 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit Glyco_hydro_63 PF03200.16 EFX01591.1 - 3.3e-170 567.1 0.1 5.1e-169 563.2 0.1 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EFX01591.1 - 5e-85 285.2 0.1 1.4e-84 283.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EFX01591.1 - 1.1e-05 24.5 0.0 2.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Trehalase Homeodomain PF00046.29 EFX01593.1 - 2.4e-14 52.9 1.5 5.5e-14 51.7 1.5 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EFX01593.1 - 0.0028 17.5 2.6 0.011 15.6 1.4 2.2 2 0 0 2 2 2 1 Homeobox KN domain Troponin-I_N PF11636.8 EFX01593.1 - 0.11 12.5 0.2 0.11 12.5 0.2 3.3 3 0 0 3 3 3 0 Troponin I residues 1-32 ADK PF00406.22 EFX01594.1 - 4.8e-22 78.7 0.0 5.6e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFX01594.1 - 1.3e-15 58.1 0.0 1.5e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFX01594.1 - 4.1e-09 37.1 0.0 4.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX01594.1 - 0.00015 22.0 0.0 0.00015 22.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFX01594.1 - 0.00032 21.0 0.0 0.00044 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Ploopntkinase3 PF18751.1 EFX01594.1 - 0.00038 20.4 0.0 0.00055 19.9 0.0 1.3 1 0 0 1 1 1 1 P-loop Nucleotide Kinase3 Cytidylate_kin PF02224.18 EFX01594.1 - 0.00088 19.1 0.0 0.0015 18.3 0.0 1.4 2 0 0 2 2 2 1 Cytidylate kinase AAA_22 PF13401.6 EFX01594.1 - 0.0013 19.0 0.1 0.0024 18.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFX01594.1 - 0.0034 17.8 0.0 0.0052 17.2 0.0 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EFX01594.1 - 0.0079 16.0 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EFX01594.1 - 0.01 16.4 0.0 0.011 16.2 0.0 1.3 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFX01594.1 - 0.02 15.3 0.0 0.026 14.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Hydin_ADK PF17213.3 EFX01594.1 - 0.026 14.8 0.1 0.073 13.4 0.0 1.7 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain RNA_helicase PF00910.22 EFX01594.1 - 0.035 14.5 0.0 0.066 13.6 0.0 1.5 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 EFX01594.1 - 0.037 13.3 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 EFX01594.1 - 0.038 14.0 0.1 0.06 13.4 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin2 PF13189.6 EFX01594.1 - 0.045 13.9 0.0 0.045 13.9 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase-like family NTPase_1 PF03266.15 EFX01594.1 - 0.061 13.2 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 EFX01594.1 - 0.075 12.2 0.0 0.12 11.6 0.0 1.4 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.15 EFX01594.1 - 0.085 12.8 0.0 0.21 11.5 0.0 1.9 1 1 0 1 1 1 0 Rad17 P-loop domain SRP54 PF00448.22 EFX01594.1 - 0.097 12.3 0.0 0.38 10.4 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RuvB_N PF05496.12 EFX01594.1 - 0.1 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EFX01594.1 - 0.13 12.2 0.8 0.27 11.1 0.8 1.8 1 1 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 EFX01594.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.5 2 0 0 2 2 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EFX01594.1 - 0.21 11.3 0.0 0.42 10.3 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation 14-3-3 PF00244.20 EFX01595.1 - 2.2e-106 354.3 4.7 2.7e-106 354.1 4.7 1.1 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C14 PF00656.22 EFX01597.1 - 0.025 14.5 0.2 0.077 12.9 0.1 1.7 1 1 0 2 2 2 0 Caspase domain MFS_1 PF07690.16 EFX01598.1 - 1.6e-26 93.0 30.8 2e-26 92.7 30.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EFX01598.1 - 2 7.2 12.2 0.013 14.4 2.4 2.0 2 0 0 2 2 2 0 MFS_1 like family HET PF06985.11 EFX01599.1 - 1.2e-23 84.1 3.7 2.1e-23 83.3 1.8 2.3 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 EFX01599.1 - 2.3e-18 66.5 0.0 3.9e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01599.1 - 6.9e-12 45.2 0.0 1.3e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_hydro_28 PF00295.17 EFX01600.1 - 4.5e-22 78.5 1.4 6.7e-22 78.0 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 EFX01600.1 - 1.2e-08 35.0 3.0 8.8e-07 29.0 0.0 2.6 1 1 2 3 3 3 2 Pectate lyase superfamily protein SGS PF05002.15 EFX01601.1 - 2.4e-27 94.8 0.6 7.7e-27 93.2 0.6 1.9 1 0 0 1 1 1 1 SGS domain CS PF04969.16 EFX01601.1 - 9.9e-09 36.1 0.0 1.9e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 CS domain Tropomodulin PF03250.14 EFX01601.1 - 0.037 14.1 1.0 0.17 11.9 0.1 2.2 2 0 0 2 2 2 0 Tropomodulin TPR_1 PF00515.28 EFX01601.1 - 0.056 13.3 3.9 0.66 9.9 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFX01601.1 - 0.24 11.6 7.6 5.5 7.4 0.3 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat Ank_2 PF12796.7 EFX01602.1 - 5.9e-33 113.3 0.5 3.3e-16 59.7 0.0 4.8 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01602.1 - 8.4e-24 83.6 1.9 1.2e-09 38.5 0.0 5.1 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX01602.1 - 3.5e-18 65.4 10.3 1.3e-08 34.9 0.4 6.6 4 1 3 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EFX01602.1 - 4.5e-16 58.5 6.1 0.00028 21.2 0.0 6.6 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EFX01602.1 - 1.4e-15 55.8 2.6 0.0024 18.2 0.0 7.0 7 1 0 7 7 6 3 Ankyrin repeat AAA_16 PF13191.6 EFX01602.1 - 6.8e-08 33.1 0.2 6.8e-08 33.1 0.2 3.2 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 EFX01602.1 - 2.1e-07 31.0 0.0 6.9e-07 29.3 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFX01602.1 - 1.5e-05 25.3 0.0 8.2e-05 22.9 0.0 2.3 1 0 0 1 1 1 1 AAA domain NACHT_N PF17100.5 EFX01602.1 - 2.7e-05 24.2 1.0 2.7e-05 24.2 1.0 2.6 3 0 0 3 3 3 1 N-terminal domain of NWD NACHT-NTPase Mg_chelatase PF01078.21 EFX01602.1 - 0.00018 21.0 0.0 0.0034 16.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFX01602.1 - 0.016 15.0 0.0 0.044 13.5 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 EFX01602.1 - 0.016 15.6 0.0 0.082 13.3 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFX01602.1 - 0.047 14.1 0.0 0.34 11.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Spo0A_C PF08769.11 EFX01602.1 - 0.052 13.6 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal TniB PF05621.11 EFX01602.1 - 0.07 12.5 0.0 0.36 10.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 EFX01602.1 - 0.086 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain KAP_NTPase PF07693.14 EFX01602.1 - 0.088 12.0 0.1 0.66 9.2 0.1 2.3 1 1 1 2 2 2 0 KAP family P-loop domain RsgA_GTPase PF03193.16 EFX01602.1 - 0.12 12.3 0.0 1.9 8.4 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase Goodbye PF17109.5 EFX01602.1 - 0.13 12.7 1.2 0.63 10.5 0.1 2.4 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain AAA_24 PF13479.6 EFX01602.1 - 0.16 11.6 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Abhydrolase_3 PF07859.13 EFX01603.1 - 1.7e-37 129.3 1.6 9.5e-36 123.6 1.6 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX01603.1 - 0.0013 18.2 0.1 0.0056 16.2 0.1 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EFX01603.1 - 0.0099 15.4 0.2 0.018 14.5 0.2 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase COesterase PF00135.28 EFX01603.1 - 0.016 14.1 0.1 0.21 10.4 0.1 1.9 2 0 0 2 2 2 0 Carboxylesterase family AXE1 PF05448.12 EFX01603.1 - 0.042 12.5 0.3 0.077 11.7 0.2 1.4 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Say1_Mug180 PF10340.9 EFX01603.1 - 0.056 12.3 0.0 0.095 11.5 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase Type_ISP_C PF18135.1 EFX01603.1 - 0.2 10.6 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain PALP PF00291.25 EFX01604.1 - 7.6e-38 130.6 0.3 1.1e-37 130.0 0.3 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Fungal_trans PF04082.18 EFX01604.1 - 8.3e-23 80.8 0.1 1.5e-22 79.9 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01604.1 - 1.3e-05 25.2 11.1 2.8e-05 24.2 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HET PF06985.11 EFX01605.1 - 6.7e-16 58.9 0.7 1.1e-15 58.3 0.7 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NACHT PF05729.12 EFX01606.1 - 9.1e-07 28.9 0.0 0.013 15.4 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 EFX01606.1 - 0.0054 17.0 0.4 0.032 14.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFX01606.1 - 0.011 15.5 0.1 0.13 12.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFX01606.1 - 0.026 14.9 0.0 0.11 12.8 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain Ank PF00023.30 EFX01606.1 - 0.035 14.6 0.0 12 6.6 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat AAA_29 PF13555.6 EFX01606.1 - 0.051 13.3 0.3 0.14 11.9 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ribul_P_3_epim PF00834.19 EFX01606.1 - 0.11 11.9 0.1 0.24 10.8 0.1 1.5 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family FAM180 PF15173.6 EFX01606.1 - 0.11 12.5 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 FAM180 family ABC_tran PF00005.27 EFX01606.1 - 0.12 12.9 0.0 0.34 11.4 0.0 1.8 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 EFX01606.1 - 0.17 12.2 0.0 0.45 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Sugar_tr PF00083.24 EFX01607.1 - 4.7e-74 249.9 19.8 5.5e-74 249.7 19.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX01607.1 - 1.4e-13 50.5 21.5 1.4e-13 50.5 21.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_5 PF05631.14 EFX01607.1 - 4.9e-05 22.4 4.6 0.00092 18.2 0.9 2.2 2 0 0 2 2 2 2 Sugar-tranasporters, 12 TM OEP PF02321.18 EFX01607.1 - 0.036 13.9 2.3 0.088 12.6 0.3 2.2 2 0 0 2 2 2 0 Outer membrane efflux protein HMG_box PF00505.19 EFX01608.1 - 2.4e-17 63.1 0.5 2.4e-17 63.1 0.5 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFX01608.1 - 1.1e-13 51.5 3.9 1.3e-12 48.1 0.3 2.6 3 0 0 3 3 3 1 HMG-box domain SAM_1 PF00536.30 EFX01608.1 - 1.3e-11 44.7 0.1 2.3e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFX01608.1 - 6.1e-11 42.3 0.1 1.1e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3808 PF10300.9 EFX01609.1 - 4e-123 411.6 0.0 4.6e-123 411.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_19 PF14559.6 EFX01609.1 - 0.84 10.2 9.4 18 5.9 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Ank_2 PF12796.7 EFX01610.1 - 1.3e-57 192.3 14.6 9.8e-15 54.9 1.8 5.6 2 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01610.1 - 9.7e-48 160.0 6.9 1.1e-14 54.6 0.0 8.6 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX01610.1 - 2.1e-37 126.7 6.5 3.2e-08 33.7 0.0 7.7 2 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EFX01610.1 - 1.4e-35 120.1 10.6 1.7e-05 25.0 0.0 9.3 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 EFX01610.1 - 4.4e-31 103.4 3.3 0.0006 20.1 0.0 10.1 9 0 0 9 9 9 7 Ankyrin repeat DUF4396 PF14342.6 EFX01612.1 - 3.7e-28 98.7 0.6 5.4e-28 98.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) HLH PF00010.26 EFX01613.1 - 2.4e-12 46.6 0.5 4.2e-12 45.8 0.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ADK PF00406.22 EFX01614.1 - 1.3e-42 145.4 0.0 1.9e-42 144.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFX01614.1 - 3.3e-32 111.8 0.0 4.6e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFX01614.1 - 4.7e-06 27.2 0.0 7.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX01614.1 - 7e-05 23.0 0.0 0.00027 21.1 0.0 2.0 2 1 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EFX01614.1 - 0.0035 17.0 0.0 1.7 8.3 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase Mito_fiss_reg PF05308.11 EFX01614.1 - 0.029 14.5 1.2 0.038 14.1 1.2 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Ploopntkinase3 PF18751.1 EFX01614.1 - 0.071 13.0 0.0 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 CAP_N PF01213.19 EFX01614.1 - 0.17 11.4 5.0 0.28 10.6 5.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal G_glu_transpept PF01019.21 EFX01614.1 - 0.17 10.6 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase PRIMA1 PF16101.5 EFX01614.1 - 0.63 10.1 5.0 1.2 9.2 5.0 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 HSP70 PF00012.20 EFX01615.1 - 2.3e-70 237.4 2.1 4.2e-70 236.6 2.1 1.4 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFX01615.1 - 3.2e-08 32.8 5.0 1.1e-07 31.0 5.0 1.9 1 1 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 EFX01615.1 - 0.013 14.6 0.6 3.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; YL1 PF05764.13 EFX01615.1 - 0.052 13.7 5.0 0.089 12.9 5.0 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Hydant_A_N PF05378.13 EFX01615.1 - 0.082 12.6 1.4 1.4 8.6 0.2 2.5 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase N-terminal region GCIP PF13324.6 EFX01615.1 - 0.3 10.6 4.9 0.59 9.7 4.9 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting FAM176 PF14851.6 EFX01615.1 - 0.38 10.4 4.8 1.9 8.2 5.3 1.8 2 0 0 2 2 2 0 FAM176 family Utp14 PF04615.13 EFX01615.1 - 0.42 9.1 6.6 0.61 8.6 6.6 1.1 1 0 0 1 1 1 0 Utp14 protein RXT2_N PF08595.11 EFX01615.1 - 0.61 10.1 5.6 1.2 9.2 5.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 EFX01615.1 - 0.62 9.9 5.3 1.1 9.1 5.3 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.12 EFX01615.1 - 0.65 9.3 13.4 1 8.6 13.4 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EFX01615.1 - 1.8 6.7 7.4 2.9 6.1 7.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 EFX01615.1 - 2 8.9 15.0 4.1 7.8 15.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.12 EFX01615.1 - 2.7 6.1 7.7 4.3 5.4 7.7 1.2 1 0 0 1 1 1 0 Nop14-like family ANAPC15 PF15243.6 EFX01615.1 - 3.5 8.1 11.1 8.2 6.9 11.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 DNA_pol_phi PF04931.13 EFX01615.1 - 3.8 5.5 13.8 5.5 5.0 13.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi MSP1_C PF07462.11 EFX01615.1 - 6.3 5.4 6.8 0.49 9.0 1.1 1.8 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus RRN3 PF05327.11 EFX01615.1 - 9 4.7 7.9 15 4.0 7.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TFIIF_alpha PF05793.12 EFX01615.1 - 9.1 4.7 12.0 14 4.1 12.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Bac_rhodopsin PF01036.18 EFX01616.1 - 2.6e-27 95.8 30.3 3.4e-27 95.5 30.3 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein HET PF06985.11 EFX01617.1 - 6.5e-17 62.2 0.2 3.3e-16 60.0 0.0 2.2 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.23 EFX01618.1 - 1.8e-05 23.6 0.0 2.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4611 PF15387.6 EFX01618.1 - 0.062 13.5 0.8 0.088 13.0 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) IATP PF04568.12 EFX01620.1 - 7.8e-26 90.4 0.1 9.9e-26 90.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF1003 PF06210.11 EFX01620.1 - 0.25 11.4 3.1 0.34 11.0 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) AAA PF00004.29 EFX01622.1 - 3.7e-07 30.6 0.0 6.1e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zot PF05707.12 EFX01622.1 - 0.0057 16.3 0.0 0.0083 15.8 0.0 1.2 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) Na_Ca_ex_C PF16494.5 EFX01623.1 - 0.011 16.2 0.1 0.022 15.2 0.1 1.5 1 1 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain COX16 PF14138.6 EFX01623.1 - 0.13 12.8 0.0 0.16 12.5 0.0 1.3 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 FAD_binding_3 PF01494.19 EFX01624.1 - 1e-74 251.9 0.0 1.4e-74 251.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EFX01624.1 - 3.2e-31 108.6 0.0 5.8e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EFX01624.1 - 5.4e-08 32.4 0.0 2.4e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX01624.1 - 1.3e-05 24.1 0.2 2.1e-05 23.4 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 EFX01624.1 - 2.3e-05 24.5 0.0 5.4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFX01624.1 - 7.8e-05 23.2 0.0 0.0027 18.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX01624.1 - 0.00012 21.1 0.0 0.00022 20.2 0.0 1.4 1 0 0 1 1 1 1 Tryptophan halogenase DAO PF01266.24 EFX01624.1 - 0.00068 19.3 0.0 0.0041 16.7 0.0 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EFX01624.1 - 0.0028 17.0 0.1 0.0046 16.3 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EFX01624.1 - 0.0035 16.5 0.0 0.0056 15.8 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EFX01624.1 - 0.0088 15.3 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EFX01624.1 - 0.0093 15.1 0.1 0.016 14.3 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EFX01624.1 - 0.011 15.1 0.1 0.02 14.2 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX01624.1 - 0.02 14.0 0.2 0.033 13.3 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EFX01624.1 - 0.023 14.3 0.1 0.038 13.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_oxidored PF12831.7 EFX01624.1 - 0.028 13.8 0.3 0.054 12.8 0.3 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EFX01624.1 - 0.046 13.1 0.0 0.21 11.0 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EFX01624.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EFX01624.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EFX01624.1 - 0.17 11.2 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 ThiF family NAD_binding_7 PF13241.6 EFX01624.1 - 0.19 12.2 0.0 0.39 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Septin PF00735.18 EFX01625.1 - 9.2e-30 103.9 0.0 2.1e-11 43.6 0.0 3.2 3 0 0 3 3 3 3 Septin Dynamin_N PF00350.23 EFX01625.1 - 0.013 15.5 0.2 0.057 13.5 0.1 2.1 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 EFX01625.1 - 0.055 12.8 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family G-alpha PF00503.20 EFX01625.1 - 0.17 11.0 0.0 0.31 10.1 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit ADH_N PF08240.12 EFX01626.1 - 4e-06 26.7 0.0 7.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF4514 PF14986.6 EFX01626.1 - 0.076 13.0 1.5 0.16 12.0 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) SLD3 PF08639.10 EFX01627.1 - 7.9e-170 566.2 2.8 5.1e-169 563.5 2.8 2.1 1 1 0 1 1 1 1 DNA replication regulator SLD3 HMGL-like PF00682.19 EFX01628.1 - 6e-50 170.2 0.0 9.8e-50 169.5 0.0 1.3 1 0 0 1 1 1 1 HMGL-like ECH_1 PF00378.20 EFX01628.1 - 5.3e-43 147.1 0.0 7.7e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFX01628.1 - 8.1e-31 107.7 0.0 1.2e-30 107.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pkinase PF00069.25 EFX01629.1 - 1.2e-75 254.3 0.0 1.6e-75 253.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01629.1 - 1.6e-37 129.2 0.0 2.1e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EFX01629.1 - 2.5e-15 56.5 0.0 4.7e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EFX01629.1 - 4.8e-12 45.8 0.0 6.4e-08 32.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Yop-YscD_cpl PF16697.5 EFX01629.1 - 4.3e-08 33.4 0.0 9.3e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 EFX01629.1 - 2.6e-06 26.5 0.0 4.4e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFX01629.1 - 0.0018 17.7 0.1 0.0036 16.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX01629.1 - 0.066 13.1 0.6 0.48 10.3 0.6 2.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFX01629.1 - 0.09 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase YrbL-PhoP_reg PF10707.9 EFX01629.1 - 0.15 11.5 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 EFX01629.1 - 0.15 11.6 0.1 13 5.4 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Telomerase_RBD PF12009.8 EFX01630.1 - 2.6e-50 170.0 0.1 6.2e-50 168.8 0.1 1.7 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EFX01630.1 - 5.7e-12 45.6 0.0 7.1e-09 35.5 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) NST1 PF13945.6 EFX01631.1 - 3.7e-46 157.7 24.1 3.7e-46 157.7 24.1 4.3 2 2 1 3 3 3 1 Salt tolerance down-regulator zf-C2H2 PF00096.26 EFX01632.1 - 9.7e-08 32.1 20.5 0.042 14.3 1.7 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX01632.1 - 1.9e-05 25.1 17.3 0.07 14.0 3.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFX01632.1 - 3.7 7.6 9.8 12 6.0 2.6 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger Trs65 PF12735.7 EFX01634.1 - 2.7e-93 312.9 0.0 3.2e-64 217.3 0.0 2.4 1 1 1 2 2 2 2 TRAPP trafficking subunit Trs65 Pkinase PF00069.25 EFX01635.1 - 6.3e-58 196.2 0.0 9.3e-57 192.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01635.1 - 8.9e-27 94.0 0.3 7.3e-21 74.6 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFX01635.1 - 1.9e-05 23.8 0.9 7e-05 21.9 0.3 1.9 1 1 1 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFX01635.1 - 0.00073 18.9 0.0 0.0018 17.6 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX01635.1 - 0.0014 18.6 3.1 0.038 13.9 0.3 2.7 2 1 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFX01635.1 - 0.0014 18.0 0.5 0.0026 17.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EFX01635.1 - 0.087 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WaaY PF06176.11 EFX01635.1 - 0.11 12.1 0.5 0.17 11.5 0.5 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 EFX01635.1 - 1.3 8.6 3.8 0.71 9.4 0.1 2.0 2 0 0 2 2 2 0 RIO1 family GREB1 PF15782.5 EFX01636.1 - 0.13 9.3 6.0 0.17 9.0 6.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 EFX01636.1 - 0.62 9.2 15.2 0.83 8.8 15.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Glyco_hydro_12 PF01670.16 EFX01637.1 - 3e-17 63.3 10.2 2.1e-16 60.6 10.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 HET PF06985.11 EFX01638.1 - 1.5e-22 80.5 0.0 2.4e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank PF00023.30 EFX01639.1 - 4.3e-08 33.3 7.7 3.4e-05 24.1 0.3 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFX01639.1 - 1.7e-06 28.1 2.1 0.00011 22.4 0.1 3.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01639.1 - 3.1e-05 24.0 2.7 0.00075 19.8 0.1 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 EFX01639.1 - 0.00025 21.6 2.7 0.0032 18.0 0.2 3.5 4 0 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01639.1 - 0.00078 20.0 0.6 0.077 13.6 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Spherulin4 PF12138.8 EFX01640.1 - 3.3e-39 134.9 0.2 4.1e-39 134.7 0.2 1.1 1 0 0 1 1 1 1 Spherulation-specific family 4 CAP59_mtransfer PF11735.8 EFX01642.1 - 6.7e-85 284.6 0.0 1.4e-84 283.6 0.0 1.5 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 RabGAP-TBC PF00566.18 EFX01643.1 - 3.9e-40 137.8 0.3 7.8e-40 136.8 0.3 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EFX01643.1 - 9.5e-08 31.7 0.0 8.3e-05 22.1 0.0 3.3 2 1 0 2 2 2 2 Rab-binding domain (RBD) LSM PF01423.22 EFX01645.1 - 1.6e-16 59.8 0.2 2.3e-16 59.2 0.2 1.3 1 0 0 1 1 1 1 LSM domain Ribosomal_S21e PF01249.18 EFX01645.1 - 0.093 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S21e HMG_CoA_synt_C PF08540.10 EFX01646.1 - 3.1e-104 348.5 0.2 3.8e-104 348.2 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EFX01646.1 - 2.6e-91 304.2 0.4 2.6e-91 304.2 0.4 1.7 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal SGTA_dimer PF16546.5 EFX01647.1 - 8.5e-26 89.5 1.3 1.5e-25 88.8 1.3 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_2 PF07719.17 EFX01647.1 - 5.4e-17 60.5 7.3 5e-05 23.1 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFX01647.1 - 2.6e-16 58.7 11.7 9e-06 25.3 0.2 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFX01647.1 - 3.2e-10 39.4 10.3 0.01 16.0 0.2 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFX01647.1 - 3.6e-08 32.9 13.6 0.0023 17.6 3.7 4.3 3 1 1 4 4 4 3 TPR repeat TPR_14 PF13428.6 EFX01647.1 - 5.9e-08 32.9 5.0 0.094 13.6 1.0 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01647.1 - 2.4e-07 31.3 9.6 4.6e-05 24.0 4.5 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFX01647.1 - 1.5e-06 28.6 5.0 0.0031 18.0 1.5 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX01647.1 - 8.9e-06 25.9 5.3 9.2e-05 22.7 2.3 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFX01647.1 - 8.9e-05 22.6 6.0 0.045 14.2 0.7 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 EFX01647.1 - 0.00067 20.1 0.5 0.19 12.2 0.3 2.4 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 EFX01647.1 - 0.0017 18.3 0.4 2.9 8.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX01647.1 - 0.0017 18.9 5.6 2.9 8.7 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX01647.1 - 0.0023 17.7 3.4 0.28 11.1 0.6 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat STI1 PF17830.1 EFX01647.1 - 0.0034 17.3 10.9 0.0046 16.9 5.9 2.5 2 0 0 2 2 2 1 STI1 domain TPR_9 PF13371.6 EFX01647.1 - 0.015 15.5 0.1 0.041 14.0 0.1 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat XPC-binding PF09280.11 EFX01647.1 - 0.099 12.4 1.1 0.21 11.4 0.9 1.6 2 0 0 2 2 2 0 XPC-binding domain ETS_PEA3_N PF04621.13 EFX01647.1 - 0.17 11.8 0.3 0.27 11.1 0.3 1.4 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain MIT PF04212.18 EFX01647.1 - 1.7 8.7 10.7 2 8.6 0.1 3.8 4 2 0 4 4 4 0 MIT (microtubule interacting and transport) domain KH_6 PF15985.5 EFX01648.1 - 6e-15 55.3 0.0 1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EFX01648.1 - 1.2e-11 44.4 0.4 3.8e-10 39.5 0.1 2.5 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain BBS2_N PF14781.6 EFX01648.1 - 0.12 12.3 0.2 0.22 11.5 0.2 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal Rhomboid PF01694.22 EFX01649.1 - 2.1e-20 73.3 17.9 8e-20 71.4 12.0 2.2 1 1 1 2 2 2 2 Rhomboid family TPR_12 PF13424.6 EFX01649.1 - 0.0006 20.0 1.0 0.26 11.6 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat HrpJ PF07201.11 EFX01649.1 - 0.14 12.5 6.0 0.39 11.0 6.0 1.8 1 0 0 1 1 1 0 HrpJ-like domain WW PF00397.26 EFX01651.1 - 1.2e-10 41.3 0.2 3e-10 40.0 0.2 1.8 1 0 0 1 1 1 1 WW domain GREB1 PF15782.5 EFX01651.1 - 1.1 6.2 26.4 1.6 5.8 26.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DDHD PF02862.17 EFX01651.1 - 1.4 9.1 11.0 3.2 7.8 11.0 1.6 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 EFX01651.1 - 5.3 5.2 37.0 7.8 4.6 37.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pkinase PF00069.25 EFX01653.1 - 5.2e-20 71.9 0.0 8.1e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01653.1 - 1.1e-15 57.6 0.0 1.9e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase VPS9 PF02204.18 EFX01654.1 - 2.3e-31 108.1 0.2 4.1e-31 107.3 0.2 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EFX01654.1 - 6.8e-15 55.1 0.2 1.4e-14 54.1 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EFX01654.1 - 4.5e-08 32.6 0.1 4.5e-07 29.4 0.0 2.2 2 0 0 2 2 2 1 CUE domain TetR_C_25 PF17933.1 EFX01656.1 - 0.11 12.9 0.1 0.5 10.7 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MFS_1 PF07690.16 EFX01657.1 - 0.0012 17.9 2.3 0.0012 17.9 2.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DEAD PF00270.29 EFX01659.1 - 2.9e-50 170.5 0.0 6.4e-49 166.1 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX01659.1 - 4.1e-29 101.2 0.2 5.4e-28 97.6 0.4 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3334 PF11813.8 EFX01659.1 - 0.039 13.7 0.0 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3334) PRAI PF00697.22 EFX01659.1 - 0.083 12.7 0.2 0.17 11.7 0.2 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Rx_N PF18052.1 EFX01660.1 - 0.0016 18.7 0.4 0.0027 18.0 0.4 1.4 1 0 0 1 1 1 1 Rx N-terminal domain DUF3584 PF12128.8 EFX01660.1 - 0.0096 13.5 1.1 0.013 13.1 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) CorA PF01544.18 EFX01660.1 - 0.012 14.9 0.6 0.016 14.5 0.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein V-SNARE PF05008.15 EFX01660.1 - 0.018 15.4 2.2 0.018 15.4 2.2 1.9 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DHR10 PF18595.1 EFX01660.1 - 0.026 14.6 3.0 0.048 13.7 3.0 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain KELK PF15796.5 EFX01660.1 - 0.027 14.9 3.0 0.053 14.0 3.0 1.5 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase GCIP PF13324.6 EFX01660.1 - 0.073 12.7 0.3 0.11 12.1 0.3 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting TRAM1 PF08390.11 EFX01660.1 - 0.17 11.6 0.0 9.3 6.0 0.0 2.5 2 0 0 2 2 2 0 TRAM1-like protein T3SSipB PF16535.5 EFX01660.1 - 0.19 12.2 8.2 0.1 13.1 2.0 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB ATG16 PF08614.11 EFX01660.1 - 3.2 7.9 10.3 6.2 7.0 10.2 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Aminotran_5 PF00266.19 EFX01661.1 - 1.9e-30 106.1 0.0 2.7e-19 69.4 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class-V Arrestin_N PF00339.29 EFX01662.1 - 7.1e-14 52.1 3.9 4.1e-13 49.6 0.0 2.8 2 1 0 2 2 1 1 Arrestin (or S-antigen), N-terminal domain PTPRCAP PF15713.5 EFX01662.1 - 0.028 14.7 20.5 0.075 13.3 20.5 1.7 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF913 PF06025.12 EFX01662.1 - 0.038 13.0 6.3 0.074 12.0 6.3 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 EFX01662.1 - 0.063 12.0 25.2 0.13 11.0 25.2 1.4 1 0 0 1 1 1 0 Presenilin eIF3_subunit PF08597.10 EFX01662.1 - 0.14 12.1 26.4 0.24 11.3 26.4 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Borrelia_P83 PF05262.11 EFX01662.1 - 0.18 10.2 16.9 0.27 9.7 16.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CDC45 PF02724.14 EFX01662.1 - 0.32 9.2 25.7 0.48 8.7 25.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 EFX01662.1 - 0.44 9.3 15.1 0.83 8.4 15.1 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SLC12 PF03522.15 EFX01662.1 - 0.49 9.4 18.7 0.74 8.8 18.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 EFX01662.1 - 1.1 8.1 10.6 1.6 7.6 10.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) LAP1C PF05609.12 EFX01662.1 - 1.3 8.0 19.5 2.5 7.1 19.5 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) ASC PF00858.24 EFX01662.1 - 1.5 7.7 6.9 2.2 7.1 6.9 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Zip PF02535.22 EFX01662.1 - 1.5 7.9 10.3 2.5 7.2 10.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4569 PF15133.6 EFX01662.1 - 1.6 8.4 19.8 3.3 7.3 19.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Nop53 PF07767.11 EFX01662.1 - 1.6 8.0 35.0 3.2 7.0 35.0 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) FAM60A PF15396.6 EFX01662.1 - 1.9 8.5 17.0 4.5 7.2 17.0 1.6 1 0 0 1 1 1 0 Protein Family FAM60A DUF2151 PF10221.9 EFX01662.1 - 1.9 7.0 10.2 2.7 6.5 10.2 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator GAGA_bind PF06217.12 EFX01662.1 - 2.1 8.6 17.6 3.7 7.8 17.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family NPR3 PF03666.13 EFX01662.1 - 2.3 6.9 20.4 4.1 6.1 20.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Raftlin PF15250.6 EFX01662.1 - 2.6 6.7 15.7 4.3 6.0 15.7 1.3 1 0 0 1 1 1 0 Raftlin SpoIIP PF07454.11 EFX01662.1 - 2.7 7.4 20.1 5.4 6.4 20.1 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SAPS PF04499.15 EFX01662.1 - 2.8 6.6 15.6 4.5 5.9 15.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MAJIN PF15077.6 EFX01662.1 - 4.9 6.9 13.8 12 5.6 13.8 1.6 1 0 0 1 1 1 0 Membrane-anchored junction protein Peptidase_S64 PF08192.11 EFX01662.1 - 6 5.2 16.8 9.6 4.5 16.8 1.2 1 0 0 1 1 1 0 Peptidase family S64 Ureide_permease PF07168.11 EFX01662.1 - 7.2 5.2 6.4 13 4.4 6.4 1.3 1 0 0 1 1 1 0 Ureide permease PIEZO PF15917.5 EFX01662.1 - 9 5.7 22.9 16 4.9 22.9 1.3 1 0 0 1 1 1 0 Piezo Spore_coat_CotO PF14153.6 EFX01662.1 - 9.3 6.1 29.8 0.69 9.8 24.4 1.8 2 0 0 2 2 1 0 Spore coat protein CotO SIR2 PF02146.17 EFX01664.1 - 8.3e-26 91.0 0.0 2.8e-25 89.3 0.0 1.8 1 1 0 1 1 1 1 Sir2 family AAA_22 PF13401.6 EFX01665.1 - 6.4e-11 42.7 0.0 1.4e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX01665.1 - 6.8e-11 42.8 0.0 2.4e-10 41.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFX01665.1 - 1.6e-08 35.0 0.0 3.8e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EFX01665.1 - 5.5e-05 23.5 1.1 0.00013 22.3 0.1 2.1 3 0 0 3 3 3 1 AAA domain Cdc6_C PF09079.11 EFX01665.1 - 0.00012 22.0 0.0 0.00032 20.6 0.0 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_lid_10 PF17872.1 EFX01665.1 - 0.0014 18.7 0.0 0.0039 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA lid domain AAA_30 PF13604.6 EFX01665.1 - 0.0019 18.0 0.3 0.0019 18.0 0.3 2.3 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFX01665.1 - 0.018 15.5 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EFX01665.1 - 0.061 13.3 0.1 0.76 9.8 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFX01665.1 - 0.081 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EFX01665.1 - 0.11 12.2 0.1 0.27 11.0 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 EFX01665.1 - 0.13 11.7 0.0 0.48 9.8 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein NTPase_1 PF03266.15 EFX01665.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 NTPase DUF4293 PF14126.6 EFX01666.1 - 0.65 10.2 9.6 3.2 8.0 5.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) ArfGap PF01412.18 EFX01667.1 - 8e-33 113.0 0.0 2.7e-32 111.3 0.0 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EFX01667.1 - 1.2e-21 77.5 9.6 1.8e-21 76.9 9.6 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EFX01667.1 - 3.5e-12 46.8 0.1 1e-11 45.3 0.1 1.8 1 0 0 1 1 1 1 PH domain EMP24_GP25L PF01105.24 EFX01667.1 - 0.17 11.8 1.2 2.8 7.9 0.7 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD PH_9 PF15410.6 EFX01667.1 - 0.27 11.6 4.4 1 9.7 1.1 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain Methyltransf_25 PF13649.6 EFX01669.1 - 4.2e-06 27.4 0.0 9.2e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01669.1 - 0.00025 21.7 0.0 0.00062 20.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01669.1 - 0.0062 16.3 0.0 0.008 16.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF3602 PF12223.8 EFX01670.1 - 4.2e-16 59.3 4.8 3.2e-13 50.1 1.8 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) TMEM108 PF15759.5 EFX01670.1 - 0.027 13.5 2.7 0.03 13.3 2.7 1.0 1 0 0 1 1 1 0 TMEM108 family DNA_gyraseA_C PF03989.13 EFX01670.1 - 0.45 10.0 3.1 3.3 7.3 0.2 2.7 3 0 0 3 3 3 0 DNA gyrase C-terminal domain, beta-propeller Erg28 PF03694.13 EFX01671.1 - 5.8 7.3 7.1 2.7 8.4 0.9 2.3 1 1 1 2 2 2 0 Erg28 like protein Trypsin_2 PF13365.6 EFX01672.1 - 0.12 13.3 0.0 3.3 8.6 0.0 2.6 1 1 0 1 1 1 0 Trypsin-like peptidase domain Tim54 PF11711.8 EFX01673.1 - 3.4e-103 345.3 0.0 1.5e-102 343.2 0.0 1.8 1 1 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Peptidase_S9 PF00326.21 EFX01674.1 - 4.9e-36 124.2 1.1 4.7e-35 121.0 1.1 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFX01674.1 - 1.6e-09 37.4 0.5 1.7e-06 27.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EFX01674.1 - 1.3e-07 31.4 0.0 8.2e-07 28.8 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EFX01674.1 - 0.00053 19.7 0.1 0.01 15.5 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EFX01674.1 - 0.00061 19.8 0.1 0.011 15.7 0.0 2.1 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 EFX01674.1 - 0.00095 19.1 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 EFX01674.1 - 0.011 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EFX01674.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 EFX01674.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Apt1 PF10351.9 EFX01676.1 - 4.6 6.0 9.1 5.6 5.7 9.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EFX01676.1 - 7.2 5.0 12.1 9 4.7 12.1 1.2 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 EFX01676.1 - 9 5.1 10.9 12 4.7 10.9 1.1 1 0 0 1 1 1 0 Mitoguardin 2OG-FeII_Oxy PF03171.20 EFX01677.1 - 4.1e-16 59.3 0.0 1.8e-15 57.3 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Bac_luciferase PF00296.20 EFX01678.1 - 2.1e-58 198.2 0.0 3.5e-58 197.5 0.0 1.3 1 0 0 1 1 1 1 Luciferase-like monooxygenase Mito_carr PF00153.27 EFX01679.1 - 1.5e-58 194.8 0.0 6.1e-19 67.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-CSL PF05207.13 EFX01680.1 - 4.5e-16 58.3 0.0 7.5e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EFX01680.1 - 8e-11 41.9 0.0 2.1e-10 40.6 0.0 1.7 1 1 0 1 1 1 1 DnaJ domain DUF1348 PF07080.11 EFX01681.1 - 3.2e-61 205.0 2.1 3.9e-61 204.7 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EFX01681.1 - 5.6e-07 30.1 1.8 8.5e-07 29.6 1.6 1.5 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFX01681.1 - 0.01 16.2 0.1 0.015 15.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) ABC_tran PF00005.27 EFX01682.1 - 1.2e-33 116.6 0.0 6.2e-16 59.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EFX01682.1 - 2.2e-13 49.8 4.7 2.2e-13 49.8 4.7 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 EFX01682.1 - 8.1e-12 45.6 5.6 0.058 13.2 0.0 4.4 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX01682.1 - 4.4e-11 42.6 0.8 0.0036 16.8 0.0 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFX01682.1 - 5.6e-07 30.1 0.0 0.0018 18.7 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 EFX01682.1 - 6.3e-06 26.6 0.0 0.018 15.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EFX01682.1 - 6.8e-06 26.0 0.0 0.18 11.5 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFX01682.1 - 1.3e-05 25.5 0.0 0.003 17.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 EFX01682.1 - 1.6e-05 24.5 1.8 1.6e-05 24.5 1.8 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Rad17 PF03215.15 EFX01682.1 - 4.5e-05 23.5 0.0 0.026 14.4 0.0 2.6 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_29 PF13555.6 EFX01682.1 - 0.00022 20.9 0.3 0.58 10.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFX01682.1 - 0.00023 21.1 0.0 1 9.2 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_23 PF13476.6 EFX01682.1 - 0.00027 21.5 0.0 0.046 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFX01682.1 - 0.00028 20.1 0.0 0.029 13.5 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 EFX01682.1 - 0.0009 19.8 0.0 1.4 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EFX01682.1 - 0.00098 18.8 0.2 1.2 8.7 0.0 2.9 3 0 0 3 3 3 1 Thymidylate kinase AAA_24 PF13479.6 EFX01682.1 - 0.00099 18.9 0.1 0.28 10.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFX01682.1 - 0.0011 19.4 0.3 0.59 10.5 0.0 3.0 3 0 0 3 3 2 1 RNA helicase Fer4_21 PF14697.6 EFX01682.1 - 0.0026 17.9 10.3 0.0055 16.8 10.3 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain NACHT PF05729.12 EFX01682.1 - 0.0026 17.7 0.9 0.35 10.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 EFX01682.1 - 0.0031 17.5 0.4 0.12 12.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) TsaE PF02367.17 EFX01682.1 - 0.0037 17.3 0.1 0.054 13.5 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFX01682.1 - 0.0038 17.5 0.3 0.46 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_6 PF12837.7 EFX01682.1 - 0.0057 16.7 1.2 0.0057 16.7 1.2 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_13 PF13166.6 EFX01682.1 - 0.0064 15.2 0.8 0.0099 14.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain Fer4_7 PF12838.7 EFX01682.1 - 0.0079 16.8 6.5 0.012 16.2 0.3 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain SRP54 PF00448.22 EFX01682.1 - 0.0085 15.7 2.1 0.35 10.5 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 EFX01682.1 - 0.0093 15.7 0.1 0.9 9.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFX01682.1 - 0.016 15.4 0.0 2.3 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 EFX01682.1 - 0.037 14.2 10.7 0.078 13.1 10.7 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain VirE PF05272.11 EFX01682.1 - 0.037 13.7 0.0 7 6.3 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E AAA_7 PF12775.7 EFX01682.1 - 0.046 13.2 0.2 0.88 9.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Fer4_16 PF13484.6 EFX01682.1 - 0.06 14.3 0.2 0.06 14.3 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain NTPase_1 PF03266.15 EFX01682.1 - 0.078 12.9 1.7 1.9 8.4 0.1 2.6 2 0 0 2 2 2 0 NTPase MukB PF04310.12 EFX01682.1 - 0.084 12.7 0.1 12 5.6 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal AAA_14 PF13173.6 EFX01682.1 - 0.14 12.2 0.3 17 5.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain Fer4_10 PF13237.6 EFX01682.1 - 0.15 12.2 16.0 0.058 13.5 2.1 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain MMR_HSR1 PF01926.23 EFX01682.1 - 0.19 11.8 0.8 27 4.9 0.0 2.8 3 0 0 3 3 2 0 50S ribosome-binding GTPase CLP1_P PF16575.5 EFX01682.1 - 0.19 11.5 0.6 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.6 EFX01682.1 - 0.24 11.0 0.1 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EFX01682.1 - 0.36 10.7 1.0 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.9 EFX01682.1 - 0.57 9.9 2.6 0.94 9.2 0.0 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Fer4_8 PF13183.6 EFX01682.1 - 5 7.7 11.0 0.7 10.4 1.5 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EFX01682.1 - 10 6.5 9.4 0.48 10.6 1.1 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Nop10p PF04135.12 EFX01683.1 - 4.2e-20 71.5 0.4 4.7e-20 71.4 0.4 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family SF3A2 PF16835.5 EFX01684.1 - 1.7e-33 114.8 0.0 2.5e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EFX01684.1 - 1.8e-06 28.1 1.1 3.3e-06 27.3 1.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EFX01684.1 - 0.00012 22.0 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein EGF_CA PF07645.15 EFX01684.1 - 0.18 12.1 0.1 0.35 11.1 0.1 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain Pyrophosphatase PF00719.19 EFX01685.1 - 2.2e-57 193.4 0.2 3.7e-57 192.6 0.2 1.4 1 0 0 1 1 1 1 Inorganic pyrophosphatase Membr_traf_MHD PF10540.9 EFX01685.1 - 2.1e-20 73.4 1.6 7.4e-10 39.2 1.1 2.8 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EFX01685.1 - 2.4e-16 59.9 0.0 5.3e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 EFX01685.1 - 1.1e-05 24.3 0.1 2.4e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) TGF_beta_GS PF08515.12 EFX01685.1 - 0.048 13.2 3.5 0.11 12.0 3.5 1.7 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Rep_N PF08724.10 EFX01685.1 - 0.067 12.9 0.1 0.21 11.3 0.1 1.8 1 0 0 1 1 1 0 Rep protein catalytic domain like Serglycin PF04360.12 EFX01685.1 - 0.14 12.1 0.6 0.3 11.0 0.6 1.5 1 0 0 1 1 1 0 Serglycin Nsp1_C PF05064.13 EFX01687.1 - 1.4e-39 134.4 6.5 3e-39 133.4 6.5 1.5 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EFX01687.1 - 7.7e-10 39.5 151.5 2.2e-06 28.4 29.9 7.2 1 1 5 6 6 4 3 Nucleoporin FG repeat region EzrA PF06160.12 EFX01687.1 - 0.069 11.3 6.1 0.89 7.6 0.0 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF1664 PF07889.12 EFX01687.1 - 0.2 11.7 5.9 3.1 7.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PI_PP_I PF18363.1 EFX01687.1 - 0.21 11.8 1.8 0.47 10.7 1.3 1.7 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Exonuc_VII_L PF02601.15 EFX01687.1 - 0.27 10.7 4.3 0.54 9.8 4.3 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-K PF11802.8 EFX01687.1 - 0.53 9.8 7.7 0.57 9.7 2.7 2.0 2 0 0 2 2 2 0 Centromere-associated protein K HIP1_clath_bdg PF16515.5 EFX01687.1 - 0.6 10.8 10.5 18 6.0 0.0 2.5 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF16 PF01519.16 EFX01687.1 - 1.2 9.7 6.9 0.36 11.3 3.2 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 DHR10 PF18595.1 EFX01687.1 - 1.3 9.1 15.5 15 5.6 0.1 2.4 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain KxDL PF10241.9 EFX01687.1 - 3.6 7.9 5.2 8.3 6.8 0.3 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein XhlA PF10779.9 EFX01687.1 - 5.1 7.4 8.2 11 6.3 0.3 3.3 3 0 0 3 3 3 0 Haemolysin XhlA DUF3450 PF11932.8 EFX01687.1 - 6 6.1 14.7 2.6 7.3 9.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BLOC1_2 PF10046.9 EFX01687.1 - 7 7.0 7.9 53 4.2 0.1 2.4 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-Q PF13094.6 EFX01687.1 - 7.4 6.8 11.4 18 5.5 10.8 1.8 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit peroxidase PF00141.23 EFX01688.1 - 3.5e-81 272.2 0.0 4.1e-45 154.2 0.0 2.2 2 0 0 2 2 2 2 Peroxidase HAD_2 PF13419.6 EFX01689.1 - 4.4e-19 69.2 0.0 6.2e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFX01689.1 - 6.8e-10 39.6 0.0 3.3e-06 27.5 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFX01689.1 - 1.1e-07 32.4 0.0 1.6e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX01689.1 - 2.2e-05 24.4 0.0 3.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EFX01689.1 - 0.071 13.2 0.0 0.69 10.0 0.0 2.3 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase GHL6 PF14871.6 EFX01689.1 - 0.19 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Med12 PF09497.10 EFX01690.1 - 1.1e-24 86.5 0.4 3.3e-24 85.0 0.4 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 MatE PF01554.18 EFX01691.1 - 6e-06 26.0 22.8 0.0012 18.6 2.7 3.8 3 1 0 3 3 3 2 MatE NACHT PF05729.12 EFX01692.1 - 2.7e-10 40.4 0.1 6.5e-10 39.2 0.1 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFX01692.1 - 3.6e-05 24.2 1.4 0.00021 21.7 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFX01692.1 - 0.003 17.8 0.0 0.013 15.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFX01692.1 - 0.021 15.2 0.0 0.082 13.3 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFX01692.1 - 0.027 14.6 0.1 0.1 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EFX01692.1 - 0.081 12.2 0.2 9.3 5.4 0.0 2.5 1 1 1 2 2 2 0 KAP family P-loop domain RNA_helicase PF00910.22 EFX01692.1 - 0.098 13.1 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Med16 PF11635.8 EFX01693.1 - 9.4e-70 235.5 0.2 1.3e-69 235.0 0.2 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 Lum_binding PF00677.17 EFX01693.1 - 1.8e-42 143.2 1.7 5e-20 71.3 0.3 2.8 2 0 0 2 2 2 2 Lumazine binding domain ANAPC4_WD40 PF12894.7 EFX01693.1 - 0.013 15.8 0.0 21 5.5 0.0 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Med3 PF11593.8 EFX01693.1 - 3.9 6.6 8.6 6.5 5.8 8.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Chorismate_synt PF01264.21 EFX01694.1 - 1.7e-135 450.9 0.0 2e-135 450.7 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase COesterase PF00135.28 EFX01695.1 - 4.9e-95 319.3 0.0 6e-95 319.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX01695.1 - 8.1e-10 38.9 0.1 2.5e-09 37.3 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX01695.1 - 0.12 11.9 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family RRM_1 PF00076.22 EFX01696.1 - 5.7e-19 67.7 0.2 1e-18 66.9 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFX01696.1 - 3.4e-05 23.4 0.0 5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFX01696.1 - 0.0037 17.1 0.0 0.012 15.5 0.0 1.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif Frankia_peptide PF14407.6 EFX01696.1 - 0.13 12.3 0.0 2.9 7.9 0.0 2.2 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DLH PF01738.18 EFX01697.1 - 7.3e-30 104.1 0.1 8.4e-30 103.9 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Ntox22 PF15527.6 EFX01697.1 - 0.056 13.5 0.2 0.2 11.7 0.1 1.8 1 1 1 2 2 2 0 Bacterial toxin 22 DUF202 PF02656.15 EFX01699.1 - 0.064 13.7 1.4 0.064 13.7 1.4 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF202) Cation_ATPase_C PF00689.21 EFX01699.1 - 2.4 7.8 15.6 1.8e+02 1.7 15.6 2.4 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus AAA_16 PF13191.6 EFX01700.1 - 6e-07 30.0 0.2 5.7e-06 26.8 0.2 2.8 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFX01700.1 - 2.7e-06 27.4 0.0 1.1e-05 25.5 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFX01700.1 - 1.1e-05 25.7 0.0 0.00014 22.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain TPR_7 PF13176.6 EFX01700.1 - 0.0014 18.5 12.6 1.9 8.7 0.1 6.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX01700.1 - 0.0062 16.8 39.1 2.9 8.2 1.6 8.9 9 1 1 10 10 10 3 Tetratricopeptide repeat AAA PF00004.29 EFX01700.1 - 0.01 16.3 0.5 0.16 12.4 0.0 3.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TPR_14 PF13428.6 EFX01700.1 - 0.064 14.1 37.2 5 8.2 0.2 11.5 12 0 0 12 12 11 0 Tetratricopeptide repeat AAA_19 PF13245.6 EFX01700.1 - 0.082 13.2 2.3 0.55 10.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain DUF2847 PF11009.8 EFX01700.1 - 0.12 12.3 0.3 0.39 10.6 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) TPR_6 PF13174.6 EFX01700.1 - 0.56 11.0 3.8 28 5.6 0.3 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat COBRA1 PF06209.13 EFX01700.1 - 0.76 8.6 9.3 0.018 14.0 2.2 1.7 2 0 0 2 2 2 0 Cofactor of BRCA1 (COBRA1) TPR_10 PF13374.6 EFX01700.1 - 1.7 8.7 19.8 8.8 6.4 0.0 6.8 8 0 0 8 8 7 0 Tetratricopeptide repeat MFS_1 PF07690.16 EFX01701.1 - 1.2e-11 44.2 15.0 2.2e-11 43.3 15.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily RhoGEF PF00621.20 EFX01702.1 - 1.6e-29 103.4 0.0 4.9e-29 101.9 0.0 1.9 2 0 0 2 2 2 1 RhoGEF domain BAR PF03114.18 EFX01702.1 - 4.5e-10 39.6 3.9 5.6e-09 36.0 2.4 2.9 2 1 0 2 2 2 1 BAR domain Phostensin_N PF13916.6 EFX01702.1 - 0.23 11.8 3.6 0.45 10.9 1.4 2.9 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal SQHop_cyclase_C PF13243.6 EFX01703.1 - 9.8e-51 172.7 0.5 2.5e-47 161.5 0.7 2.6 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EFX01703.1 - 6.1e-38 130.6 3.6 1.2e-33 116.5 0.9 3.0 3 1 0 3 3 3 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EFX01703.1 - 1.8e-29 101.2 1.9 5.9e-09 35.5 0.2 3.8 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EFX01703.1 - 0.014 14.5 0.3 0.11 11.5 0.0 2.3 2 1 0 2 2 2 0 A-macroglobulin TED domain Pec_lyase PF09492.10 EFX01703.1 - 0.039 13.3 0.0 4.2 6.6 0.0 3.5 2 1 1 3 3 3 0 Pectic acid lyase Flavin_Reduct PF01613.18 EFX01705.1 - 1.9e-07 31.3 0.0 2.2e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Putative_PNPOx PF01243.20 EFX01705.1 - 0.0029 17.7 0.0 0.0039 17.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF447 PF04289.12 EFX01705.1 - 0.0055 16.5 0.0 0.0063 16.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF447) AAA PF00004.29 EFX01706.1 - 1.6e-16 61.0 0.0 7.1e-16 58.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX01706.1 - 0.00081 19.7 1.1 0.0054 17.0 0.1 2.6 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EFX01706.1 - 0.0024 18.3 0.1 0.0062 16.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EFX01706.1 - 0.011 15.4 0.2 0.04 13.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFX01706.1 - 0.014 15.4 0.0 0.034 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EFX01706.1 - 0.042 14.2 0.5 0.11 12.8 0.3 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFX01706.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.6 EFX01706.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFX01706.1 - 0.14 12.4 0.4 0.32 11.2 0.4 1.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFX01706.1 - 0.15 11.4 0.3 1 8.7 0.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 EFX01706.1 - 0.18 11.9 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Torsin HET PF06985.11 EFX01707.1 - 0.0018 18.6 0.0 0.0037 17.6 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Radical_SAM PF04055.21 EFX01708.1 - 2.2e-11 44.4 0.1 8.2e-11 42.6 0.1 1.9 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EFX01708.1 - 5.3e-06 26.8 0.2 1.3e-05 25.5 0.2 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EFX01708.1 - 5.4e-05 23.3 0.6 0.00023 21.3 0.1 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain SNF2_N PF00176.23 EFX01709.1 - 1.1e-53 182.2 0.0 1.8e-53 181.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EFX01709.1 - 6.2e-27 93.3 2.6 7.8e-16 57.7 0.2 3.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EFX01709.1 - 5.2e-20 71.9 0.0 1.1e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 EFX01709.1 - 4.3e-11 43.1 0.0 1e-08 35.5 0.0 3.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4208) HDA2-3 PF11496.8 EFX01709.1 - 2.8e-08 33.3 0.0 8.2e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Cdh1_DBD_1 PF18196.1 EFX01709.1 - 1.9e-07 31.4 0.1 1.9e-07 31.4 0.1 6.0 5 1 1 6 6 6 2 Chromodomain helicase DNA-binding domain 1 ResIII PF04851.15 EFX01709.1 - 1e-06 28.9 0.0 4.7e-06 26.7 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SLIDE PF09111.10 EFX01709.1 - 0.0085 16.1 0.1 0.075 13.1 0.0 2.6 2 0 0 2 2 2 1 SLIDE CHDCT2 PF08074.11 EFX01709.1 - 0.028 14.6 0.1 0.17 12.0 0.0 2.4 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain AAA_22 PF13401.6 EFX01709.1 - 0.04 14.2 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain POR PF01558.18 EFX01709.1 - 0.2 11.7 0.3 0.63 10.1 0.0 1.9 2 0 0 2 2 2 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Zn_clus PF00172.18 EFX01710.1 - 1.2e-07 31.7 7.3 2.6e-07 30.7 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX01710.1 - 2.2e-05 23.6 0.7 3.9e-05 22.8 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_transf_90 PF05686.12 EFX01711.1 - 2.3e-10 40.0 0.1 7e-09 35.1 0.0 2.6 3 0 0 3 3 3 1 Glycosyl transferase family 90 TauE PF01925.19 EFX01711.1 - 0.46 10.1 3.6 0.75 9.4 3.6 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE MBOAT_2 PF13813.6 EFX01712.1 - 4.1e-15 55.8 3.7 4.1e-15 55.8 3.7 2.4 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family NMT1 PF09084.11 EFX01712.1 - 5.2e-07 29.8 0.1 8.6e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 EFX01712.1 - 0.014 15.0 2.7 0.024 14.2 2.7 1.4 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein FolB PF02152.18 EFX01713.1 - 2.5e-26 92.4 0.2 1.7e-21 76.9 0.4 2.4 3 0 0 3 3 3 2 Dihydroneopterin aldolase Pyr_redox_3 PF13738.6 EFX01714.1 - 1.4e-11 44.2 0.0 2e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX01714.1 - 4.3e-10 39.3 0.1 1.5e-07 30.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFX01714.1 - 4.6e-07 29.4 0.3 0.00043 19.6 0.2 2.2 1 1 1 2 2 2 2 FAD binding domain K_oxygenase PF13434.6 EFX01714.1 - 3e-06 26.6 0.2 3.5e-05 23.1 0.1 2.4 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EFX01714.1 - 0.0024 17.0 0.2 0.009 15.1 0.2 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EFX01714.1 - 0.0058 16.3 0.2 4.8 6.6 0.0 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX01714.1 - 0.0074 16.5 0.0 0.027 14.7 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFX01714.1 - 0.046 13.0 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EFX01714.1 - 0.06 12.0 0.0 0.097 11.4 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 EFX01714.1 - 0.11 12.5 1.7 24 4.9 0.0 3.1 2 1 1 3 3 3 0 FAD-NAD(P)-binding DUF4440 PF14534.6 EFX01714.1 - 0.11 12.9 0.1 0.3 11.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) 2-Hacid_dh_C PF02826.19 EFX01714.1 - 0.14 11.5 0.0 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFX01714.1 - 0.15 12.6 0.0 0.38 11.4 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX01714.1 - 0.19 11.1 1.1 2.1 7.6 1.1 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX01714.1 - 0.86 8.6 4.9 0.3 10.1 0.1 2.5 3 1 0 3 3 3 0 FAD binding domain FMO-like PF00743.19 EFX01715.1 - 9.2e-18 63.9 0.1 1.4e-16 60.0 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFX01715.1 - 7.4e-11 41.8 0.0 7.1e-08 32.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX01715.1 - 1.1e-10 41.6 0.1 4.1e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFX01715.1 - 1.7e-07 30.8 0.0 5.8e-07 29.1 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX01715.1 - 5.8e-07 29.0 0.2 0.0002 20.6 0.0 3.3 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFX01715.1 - 6.8e-05 22.9 0.3 0.022 14.8 0.0 3.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EFX01715.1 - 0.047 13.3 1.6 14 5.1 0.3 3.2 1 1 1 3 3 3 0 FAD dependent oxidoreductase Malic_M PF03949.15 EFX01715.1 - 0.13 11.6 0.0 14 4.9 0.0 2.2 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain IPPT PF01715.17 EFX01715.1 - 0.13 12.0 0.0 4.2 7.1 0.0 2.1 2 0 0 2 2 2 0 IPP transferase TrmE_N PF10396.9 EFX01716.1 - 4e-36 123.8 0.0 9.9e-36 122.6 0.0 1.7 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 EFX01716.1 - 1.7e-28 100.2 0.1 3.2e-28 99.3 0.1 1.5 1 0 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EFX01716.1 - 2e-16 60.1 0.0 3.5e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFX01716.1 - 0.00028 21.0 0.0 0.00045 20.3 0.0 1.4 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 EFX01716.1 - 0.0003 20.4 0.0 0.00065 19.3 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFX01716.1 - 0.00048 20.1 0.0 0.41 10.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Glyco_hydro_3_C PF01915.22 EFX01716.1 - 0.0042 17.1 0.1 0.0086 16.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain ABC_tran PF00005.27 EFX01716.1 - 0.072 13.6 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF1118 PF06549.12 EFX01716.1 - 0.25 11.7 1.3 2.3 8.5 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1118) PGK PF00162.19 EFX01717.1 - 2.2e-150 500.8 0.3 2.5e-150 500.6 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase FIVAR PF07554.13 EFX01717.1 - 0.039 14.7 0.1 8.8 7.2 0.0 3.7 4 0 0 4 4 4 0 FIVAR domain DUF3530 PF12048.8 EFX01717.1 - 0.073 12.5 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Pyr_redox PF00070.27 EFX01717.1 - 0.18 12.4 2.2 13 6.5 0.2 3.1 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF2715 PF10895.8 EFX01718.1 - 0.083 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2715) CCDC50_N PF15295.6 EFX01718.1 - 0.095 12.9 0.0 1.8 8.7 0.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus AAA PF00004.29 EFX01719.1 - 1.2e-40 139.0 0.0 2e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX01719.1 - 6.8e-07 29.0 0.0 1.7e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFX01719.1 - 2.6e-05 24.3 0.1 9.9e-05 22.4 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFX01719.1 - 8.8e-05 22.8 0.0 0.0061 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX01719.1 - 0.00012 22.5 0.1 0.0026 18.2 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EFX01719.1 - 0.00043 20.4 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EFX01719.1 - 0.00075 18.7 0.0 0.0014 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFX01719.1 - 0.0032 17.2 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EFX01719.1 - 0.0083 15.7 0.0 0.022 14.2 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 EFX01719.1 - 0.011 16.0 0.1 0.026 14.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFX01719.1 - 0.021 15.0 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFX01719.1 - 0.026 14.3 0.2 0.13 12.0 0.0 2.3 3 1 0 3 3 2 0 AAA domain ATPase_2 PF01637.18 EFX01719.1 - 0.032 14.1 0.4 5.7 6.8 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EFX01719.1 - 0.037 14.4 0.0 0.097 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EFX01719.1 - 0.037 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFX01719.1 - 0.047 14.2 0.0 0.15 12.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 EFX01719.1 - 0.049 12.8 0.0 0.097 11.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EFX01719.1 - 0.06 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 EFX01719.1 - 0.061 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 EFX01719.1 - 0.069 12.9 0.1 0.6 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFX01719.1 - 0.1 12.3 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EFX01719.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EFX01719.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ANAPC4_WD40 PF12894.7 EFX01720.1 - 0.00047 20.4 0.0 0.24 11.7 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EFX01720.1 - 0.0042 17.0 0.1 0.079 12.9 0.0 2.9 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat WD40 PF00400.32 EFX01720.1 - 0.014 16.2 5.7 5 8.2 0.0 5.0 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF3810 PF12725.7 EFX01721.1 - 5 6.4 6.5 18 4.5 4.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Sec20 PF03908.13 EFX01722.1 - 8.4e-08 32.0 0.0 2.5e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 Sec20 Methyltransf_17 PF12692.7 EFX01722.1 - 0.03 14.3 0.1 0.073 13.1 0.1 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase DUF4734 PF15881.5 EFX01722.1 - 0.19 11.9 1.1 0.39 10.9 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) GET2 PF08690.10 EFX01722.1 - 0.96 9.1 11.8 4.4 6.9 0.1 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 DUF5327 PF17261.2 EFX01722.1 - 5.5 7.8 13.7 7.8 7.3 0.7 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Sporozoite_P67 PF05642.11 EFX01722.1 - 9.4 4.2 12.8 1.6 6.7 2.5 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen CYTH PF01928.21 EFX01723.1 - 1.4e-11 44.7 0.1 2.1e-11 44.1 0.1 1.2 1 0 0 1 1 1 1 CYTH domain FOXO_KIX_bdg PF16675.5 EFX01723.1 - 0.11 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 KIX-binding domain of forkhead box O, CR2 Mso1_Sec1_bdg PF14475.6 EFX01724.1 - 9e-18 63.6 0.0 1.5e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Amidohydro_1 PF01979.20 EFX01725.1 - 4.9e-16 59.0 0.7 8.6e-13 48.3 0.7 2.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX01725.1 - 9.3e-09 35.3 0.4 6.5e-06 25.9 0.1 2.6 2 1 0 2 2 2 2 Amidohydrolase family Ank_2 PF12796.7 EFX01726.1 - 1.2e-24 86.7 15.7 1.6e-10 41.4 0.8 4.4 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01726.1 - 2.3e-15 56.7 6.8 2e-05 25.1 0.1 5.6 4 2 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01726.1 - 9e-15 53.3 10.8 0.015 15.8 0.0 8.6 10 0 0 10 10 10 3 Ankyrin repeat Ank_5 PF13857.6 EFX01726.1 - 2.2e-13 50.2 10.7 0.00015 21.9 0.1 6.4 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFX01726.1 - 1.6e-06 28.3 15.4 0.01 16.2 0.1 7.3 8 0 0 8 8 8 2 Ankyrin repeat Cnd2 PF05786.14 EFX01727.1 - 2.7e-296 985.3 0.0 3.1e-296 985.1 0.0 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EFX01727.1 - 0.051 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal MFS_1 PF07690.16 EFX01728.1 - 4.2e-42 144.3 24.9 4.2e-42 144.3 24.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EFX01728.1 - 0.0022 17.1 0.0 0.0046 16.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_25 PF13649.6 EFX01730.1 - 6.5e-11 42.8 0.0 1.4e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFX01730.1 - 1.5e-10 41.0 0.1 2.3e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFX01730.1 - 4e-09 36.4 0.0 6.5e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01730.1 - 4.5e-08 33.6 0.0 1.1e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFX01730.1 - 5.8e-07 28.7 0.1 8.4e-07 28.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 EFX01730.1 - 4.6e-05 23.4 0.1 8e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX01730.1 - 7e-05 22.7 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFX01730.1 - 0.00038 19.8 0.0 0.00052 19.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EFX01730.1 - 0.0004 21.1 0.0 0.00075 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PRMT5_C PF17286.2 EFX01730.1 - 0.00087 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_2 PF00891.18 EFX01730.1 - 0.0023 17.2 0.1 0.0041 16.4 0.1 1.4 1 0 0 1 1 1 1 O-methyltransferase domain PRMT5 PF05185.16 EFX01730.1 - 0.0042 17.0 0.2 0.0078 16.1 0.2 1.5 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase MTS PF05175.14 EFX01730.1 - 0.0054 16.3 0.1 0.0086 15.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFX01730.1 - 0.069 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltrans_SAM PF10672.9 EFX01730.1 - 0.14 11.2 0.1 0.23 10.6 0.1 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 EFX01730.1 - 0.16 11.6 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 STIMATE PF12400.8 EFX01731.1 - 1.7e-40 138.4 2.4 3.4e-40 137.5 2.4 1.5 1 0 0 1 1 1 1 STIMATE family CAP_N PF01213.19 EFX01731.1 - 3.8 6.9 5.8 8.3 5.8 5.8 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HSP70 PF00012.20 EFX01732.1 - 2.8e-05 22.5 0.0 5.6e-05 21.5 0.0 1.5 1 1 0 1 1 1 1 Hsp70 protein TPP_enzyme_C PF02775.21 EFX01733.1 - 2.6e-50 170.2 0.9 1.2e-48 164.8 0.0 3.1 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_N PF02776.18 EFX01733.1 - 7.7e-49 165.6 0.1 1.5e-47 161.4 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EFX01733.1 - 3.1e-40 137.1 0.2 6.4e-40 136.1 0.2 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 EFX01733.1 - 0.037 13.8 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg His_Phos_2 PF00328.22 EFX01736.1 - 7.6e-31 107.8 0.0 9.4e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF5102 PF17104.5 EFX01737.1 - 2.1e-93 313.5 0.0 3.4e-93 312.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) Oxidored_FMN PF00724.20 EFX01738.1 - 2.2e-87 293.5 0.0 2.5e-87 293.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family SNF2_N PF00176.23 EFX01739.1 - 1.1e-11 44.1 0.0 9.2e-11 41.0 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EFX01739.1 - 0.00038 20.5 0.0 0.0029 17.6 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFX01739.1 - 0.002 18.5 0.0 0.0047 17.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFX01739.1 - 0.013 15.2 0.0 0.072 12.8 0.0 2.0 2 0 0 2 2 2 0 DEAD/DEAH box helicase CNDH2_C PF16858.5 EFX01739.1 - 0.1 12.4 10.0 0.11 12.4 1.4 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term MFS_1 PF07690.16 EFX01740.1 - 1.2e-20 73.7 30.9 1.2e-20 73.7 30.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX01740.1 - 1.8e-05 23.8 3.1 1.8e-05 23.8 3.1 3.1 3 1 1 4 4 4 1 Sugar (and other) transporter Ldr_toxin PF13940.6 EFX01740.1 - 0.051 13.7 0.1 0.051 13.7 0.1 2.7 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system MFS_1 PF07690.16 EFX01741.1 - 4.3e-36 124.6 28.3 6.1e-36 124.1 28.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFX01741.1 - 0.00015 21.2 2.5 0.00015 21.2 2.5 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB ASFV_J13L PF05568.11 EFX01741.1 - 0.011 15.5 0.1 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Ada_Zn_binding PF02805.16 EFX01742.1 - 9.3e-29 99.3 7.1 1.7e-28 98.5 7.1 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_18 PF12833.7 EFX01742.1 - 4.8e-08 33.1 0.2 1e-07 32.1 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 EFX01742.1 - 1.4e-07 31.5 0.0 2.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family DUF1398 PF07166.11 EFX01742.1 - 0.035 14.2 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) Velvet PF11754.8 EFX01743.1 - 5.8e-95 318.0 5.5 2.8e-94 315.7 0.0 2.0 2 0 0 2 2 2 1 Velvet factor FAM104 PF15434.6 EFX01743.1 - 0.035 14.7 3.7 0.095 13.3 3.7 1.8 1 0 0 1 1 1 0 Family 104 CCDC53 PF10152.9 EFX01743.1 - 0.56 10.6 5.6 51 4.2 6.1 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Lin-8 PF03353.15 EFX01743.1 - 3.8 7.0 5.3 6.1 6.3 5.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Spt20 PF12090.8 EFX01743.1 - 4.8 6.7 11.4 8.3 5.9 11.4 1.3 1 0 0 1 1 1 0 Spt20 family HAMP PF00672.25 EFX01744.1 - 5e-38 129.3 14.1 5.6e-08 33.0 0.2 7.1 6 0 0 6 6 6 5 HAMP domain HATPase_c PF02518.26 EFX01744.1 - 8.5e-32 110.0 0.1 2.4e-31 108.5 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFX01744.1 - 1.1e-27 96.4 0.5 6.5e-27 93.9 0.5 2.4 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFX01744.1 - 4.3e-16 58.7 4.7 9.1e-16 57.7 0.7 3.5 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Syntaxin_2 PF14523.6 EFX01744.1 - 5.7e-08 33.1 9.6 0.47 10.8 0.0 6.9 3 2 2 6 6 6 3 Syntaxin-like protein GLE1 PF07817.13 EFX01744.1 - 0.00024 20.4 3.5 3.7 6.7 0.2 3.9 2 1 2 4 4 4 3 GLE1-like protein Gp-FAR-1 PF05823.12 EFX01744.1 - 0.00059 20.2 0.4 24 5.3 0.0 5.2 3 1 2 5 5 5 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fib_alpha PF08702.10 EFX01744.1 - 0.0019 18.4 26.1 0.16 12.1 1.3 6.2 6 0 0 6 6 6 2 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EFX01744.1 - 0.0021 18.3 45.3 0.28 11.5 0.3 9.2 4 1 3 7 7 6 2 Bacterial protein of unknown function (DUF948) DUF4279 PF14106.6 EFX01744.1 - 0.0043 17.2 0.0 16 5.7 0.0 4.5 5 0 0 5 5 4 0 Domain of unknown function (DUF4279) DUF3829 PF12889.7 EFX01744.1 - 0.012 15.1 3.7 3.8 6.9 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3829) HTH_6 PF01418.17 EFX01744.1 - 0.11 12.5 0.0 19 5.3 0.0 4.0 4 0 0 4 4 4 0 Helix-turn-helix domain, rpiR family WAPL PF07814.13 EFX01744.1 - 0.13 11.0 5.4 2.8 6.6 0.1 2.6 2 0 0 2 2 2 0 Wings apart-like protein regulation of heterochromatin BORCS6 PF10157.9 EFX01744.1 - 0.24 11.6 9.7 5.5 7.2 0.1 5.2 4 2 1 5 5 5 0 BLOC-1-related complex sub-unit 6 GhoS PF11080.8 EFX01744.1 - 0.3 11.1 4.6 2.6 8.1 0.0 3.7 4 0 0 4 4 4 0 Endoribonuclease GhoS CENP-F_leu_zip PF10473.9 EFX01744.1 - 3.6 7.6 24.2 1.9 8.5 0.1 7.0 8 2 1 9 9 9 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AdHead_fibreRBD PF16812.5 EFX01744.1 - 4.2 7.2 6.8 5.4 6.8 0.2 3.5 3 0 0 3 3 3 0 C-terminal head domain of the fowl adenovirus type 1 long fibre PAF-AH_p_II PF03403.13 EFX01745.1 - 1.9e-40 138.6 0.0 4.9e-35 120.8 0.0 2.3 2 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EFX01745.1 - 0.00014 20.8 0.0 0.00032 19.7 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EFX01745.1 - 0.00076 18.8 0.1 1.1 8.5 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EFX01745.1 - 0.0052 15.9 0.0 0.0083 15.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase MFS_1 PF07690.16 EFX01749.1 - 1.8e-29 102.8 30.1 1.8e-29 102.8 30.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX01749.1 - 6.2e-09 35.2 6.3 6.2e-09 35.2 6.3 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFX01749.1 - 0.0011 17.5 0.2 0.0017 16.9 0.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4381 PF14316.6 EFX01749.1 - 2.4 8.4 7.5 0.2 11.9 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Ank_4 PF13637.6 EFX01750.1 - 1.8e-20 73.0 5.6 4.1e-08 33.6 0.0 5.8 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX01750.1 - 1.9e-20 73.2 0.1 1.4e-14 54.4 0.0 4.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX01750.1 - 9.1e-15 53.3 2.4 1.9e-05 24.7 0.0 6.7 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFX01750.1 - 2.7e-14 52.9 3.2 0.015 15.7 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EFX01750.1 - 6.4e-10 39.1 7.7 2.8e-07 30.7 0.1 4.4 4 1 1 5 5 5 3 Ankyrin repeats (many copies) MRP_L53 PF10780.9 EFX01751.1 - 2.3e-21 75.7 0.1 3.2e-21 75.2 0.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 KorB_C PF06613.11 EFX01751.1 - 0.07 13.1 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 KorB C-terminal beta-barrel domain TauD PF02668.16 EFX01752.1 - 2.3e-38 132.5 1.2 3.8e-38 131.8 1.2 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EFX01752.1 - 1.1e-05 24.8 0.0 2.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 CsiD DUF971 PF06155.12 EFX01752.1 - 1.1e-05 26.0 0.0 2.7e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF971) 2OG-FeII_Oxy_3 PF13640.6 EFX01752.1 - 0.15 13.0 0.3 0.59 11.1 0.3 2.1 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Na_Ca_ex PF01699.24 EFX01753.1 - 1.4e-42 145.2 47.0 3.9e-23 82.1 20.1 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein MARVEL PF01284.23 EFX01753.1 - 0.0086 16.1 0.3 0.0086 16.1 0.3 4.4 2 2 1 3 3 3 1 Membrane-associating domain Sporozoite_P67 PF05642.11 EFX01753.1 - 0.37 8.8 17.7 0.02 13.0 0.5 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 EFX01753.1 - 0.84 7.7 1.5 1.4 7.0 1.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF5310 PF17237.2 EFX01753.1 - 3.6 7.5 5.1 1.5 8.8 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5310) DUF4381 PF14316.6 EFX01753.1 - 7.8 6.7 11.4 1.9 8.7 0.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) AA_permease_2 PF13520.6 EFX01754.1 - 1.3e-65 221.9 44.1 1.6e-65 221.6 44.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX01754.1 - 3.8e-16 58.7 33.6 3.8e-16 58.7 33.6 1.3 1 1 0 1 1 1 1 Amino acid permease SR-25 PF10500.9 EFX01754.1 - 0.084 12.5 0.1 0.12 11.9 0.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Catalase PF00199.19 EFX01755.1 - 2.4e-135 451.5 0.5 3e-80 270.2 0.3 2.1 1 1 1 2 2 2 2 Catalase Fungal_trans_2 PF11951.8 EFX01755.1 - 5.7e-18 64.9 2.5 8.9e-18 64.3 2.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MOSC PF03473.17 EFX01756.1 - 7.9e-38 129.4 0.1 1.4e-37 128.6 0.1 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EFX01756.1 - 2.2e-20 72.7 0.0 7.1e-20 71.1 0.0 2.0 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 EFX01756.1 - 1.7e-17 63.5 0.0 2.6e-11 43.1 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-V PMM PF03332.13 EFX01757.1 - 1.7e-101 338.6 0.1 2e-101 338.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EFX01757.1 - 0.00081 19.2 0.0 0.025 14.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFX01757.1 - 0.11 12.9 0.0 9.4 6.6 0.0 2.8 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase eIF2_C PF09173.11 EFX01758.1 - 3.7e-34 116.8 0.4 9.6e-34 115.5 0.4 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EFX01758.1 - 5.4e-23 81.5 1.9 6.7e-22 78.0 1.9 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFX01758.1 - 3e-10 40.4 0.2 9.5e-10 38.7 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFX01758.1 - 0.01 15.9 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EFX01758.1 - 0.03 14.4 1.0 0.07 13.1 0.1 2.0 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EFX01758.1 - 0.069 13.1 0.3 0.64 9.9 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase MFS_1 PF07690.16 EFX01759.1 - 1.9e-09 36.9 32.6 2.6e-08 33.2 16.5 2.1 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF4185 PF13810.6 EFX01760.1 - 5.3e-07 29.2 0.0 1.1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) ATP-synt_I PF03899.15 EFX01760.1 - 0.14 12.5 0.2 0.14 12.5 0.2 2.5 2 1 0 2 2 2 0 ATP synthase I chain DAO PF01266.24 EFX01761.1 - 1.8e-30 106.8 1.3 2.8e-30 106.1 1.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF4880 PF16220.5 EFX01761.1 - 0.0075 16.1 0.1 0.021 14.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4880) Thi4 PF01946.17 EFX01761.1 - 0.023 13.9 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 EFX01761.1 - 0.031 14.5 6.1 0.077 13.2 0.0 3.8 4 0 0 4 4 4 0 NAD(P)-binding Rossmann-like domain ETX_MTX2 PF03318.13 EFX01762.1 - 0.00015 21.6 14.1 0.00016 21.6 12.7 1.5 1 1 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Mitoc_mL59 PF18126.1 EFX01763.1 - 5.6e-45 152.8 2.9 6.6e-45 152.6 2.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 ABC_tran PF00005.27 EFX01765.1 - 2.1e-12 47.8 0.0 3e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter DUF87 PF01935.17 EFX01765.1 - 0.0017 18.5 0.1 0.0069 16.5 0.0 1.8 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_29 PF13555.6 EFX01765.1 - 0.011 15.5 0.1 0.029 14.1 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFX01765.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.6 EFX01765.1 - 0.02 15.4 0.0 0.037 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFX01765.1 - 0.053 12.6 0.0 0.095 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EFX01765.1 - 0.088 13.1 0.0 0.24 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Glyco_transf_21 PF13506.6 EFX01766.1 - 6.6e-13 48.5 0.1 0.00011 21.8 0.0 3.4 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EFX01766.1 - 2.8e-11 43.7 0.0 1.6e-10 41.3 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFX01766.1 - 0.00049 19.9 0.0 0.0025 17.6 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 2 CoA_transf_3 PF02515.17 EFX01767.1 - 3.3e-126 421.3 0.0 4.2e-126 421.0 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III ADH_N PF08240.12 EFX01768.1 - 0.00021 21.1 0.0 0.00046 20.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX01768.1 - 0.00081 19.4 0.0 0.0019 18.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX01768.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF2154 PF09922.9 EFX01768.1 - 0.16 11.8 0.0 0.36 10.7 0.0 1.6 1 1 0 1 1 1 0 Cell wall-active antibiotics response 4TMS YvqF FR47 PF08445.10 EFX01769.1 - 5.3e-05 23.1 0.0 0.00042 20.2 0.0 2.3 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 EFX01769.1 - 0.094 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FF PF01846.19 EFX01770.1 - 1.8e-50 168.9 2.5 2e-12 47.1 0.0 5.7 5 0 0 5 5 5 5 FF domain WW PF00397.26 EFX01770.1 - 4.9e-20 71.3 12.2 7.7e-11 41.9 0.9 2.6 2 0 0 2 2 2 2 WW domain Lipin_mid PF16876.5 EFX01770.1 - 0.12 12.5 0.0 5.1 7.3 0.0 3.3 3 0 0 3 3 3 0 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF87 PF01935.17 EFX01770.1 - 0.6 10.2 2.2 2.2 8.3 2.2 2.0 1 0 0 1 1 1 0 Helicase HerA, central domain Glyco_hyd_101C PF17451.2 EFX01770.1 - 0.61 10.4 7.4 8 6.8 0.2 2.7 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain RRM_1 PF00076.22 EFX01771.1 - 3.3e-20 71.7 0.0 5.6e-11 42.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFX01771.1 - 0.00038 20.3 0.0 0.24 11.3 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EFX01771.1 - 0.15 12.1 0.0 1.9 8.6 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif Glyco_hydro_106 PF17132.4 EFX01772.1 - 1.9e-27 95.9 0.1 4.6e-27 94.7 0.0 1.6 2 0 0 2 2 2 1 alpha-L-rhamnosidase Glyco_hydro_2_N PF02837.18 EFX01772.1 - 0.0054 16.7 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Cyclin PF08613.11 EFX01773.1 - 5.1e-10 40.0 0.0 8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EFX01773.1 - 4.9e-05 23.1 0.0 7.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain CBFD_NFYB_HMF PF00808.23 EFX01775.1 - 9.8e-10 38.6 0.0 1.9e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFX01775.1 - 3.7e-07 30.6 0.0 3.7e-07 30.6 0.0 2.5 3 1 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFX01775.1 - 0.0014 18.7 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAFII28 PF04719.14 EFX01775.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Nop14 PF04147.12 EFX01775.1 - 6.7 4.8 28.6 10 4.2 28.6 1.4 1 0 0 1 1 1 0 Nop14-like family DUF868 PF05910.12 EFX01776.1 - 0.05 13.2 0.0 0.062 12.9 0.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF868) TPR_1 PF00515.28 EFX01777.1 - 9.8e-05 22.0 1.9 0.28 11.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFX01777.1 - 0.003 17.5 9.1 1.2 9.4 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX01777.1 - 0.011 16.1 1.1 0.011 16.1 1.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFX01777.1 - 0.044 14.4 5.8 0.93 10.2 5.0 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 EFX01777.1 - 0.093 12.9 1.2 0.18 12.0 0.0 2.1 3 0 0 3 3 3 0 DnaJ domain DUF630 PF04783.12 EFX01777.1 - 0.87 9.8 2.9 0.89 9.8 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF630) TPR_4 PF07721.14 EFX01777.1 - 1 10.2 4.3 48 5.0 0.6 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFX01778.1 - 1.3e-05 25.4 11.0 0.0025 18.1 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Ank_4 PF13637.6 EFX01778.1 - 0.0047 17.5 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) TPR_16 PF13432.6 EFX01778.1 - 0.057 14.1 0.5 0.057 14.1 0.5 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFX01778.1 - 9.8 6.6 6.8 18 5.7 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ADH_zinc_N PF00107.26 EFX01779.1 - 2.3e-17 63.2 3.9 4.5e-17 62.3 3.9 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX01779.1 - 2.4e-17 62.8 0.3 1.4e-16 60.3 0.3 2.2 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFX01779.1 - 1.9e-07 32.2 0.2 2.2e-06 28.7 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX01779.1 - 0.00022 20.6 5.8 0.00058 19.2 5.8 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Glu_dehyd_C PF16912.5 EFX01779.1 - 0.0027 17.2 5.1 0.005 16.4 5.1 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus NAD_binding_2 PF03446.15 EFX01779.1 - 0.007 16.5 0.7 0.017 15.3 0.3 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFX01779.1 - 0.0072 15.7 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EFX01779.1 - 0.069 12.7 0.4 0.13 11.8 0.4 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EFX01779.1 - 0.14 12.0 0.7 0.34 10.8 0.7 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Met_10 PF02475.16 EFX01779.1 - 0.17 11.6 0.1 0.17 11.6 0.1 1.5 2 0 0 2 2 2 0 Met-10+ like-protein adh_short PF00106.25 EFX01780.1 - 3.2e-22 78.9 0.0 1.1e-19 70.7 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX01780.1 - 4.7e-13 49.2 0.1 2.1e-11 43.8 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX01780.1 - 8.1e-08 32.4 0.1 1.4e-07 31.7 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX01780.1 - 0.00054 19.5 0.1 0.00073 19.1 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family CRC_subunit PF08624.10 EFX01781.1 - 4.2e-53 179.4 0.0 5.9e-53 178.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit CFEM PF05730.11 EFX01782.1 - 2.3e-09 37.2 6.0 2.3e-09 37.2 6.0 1.6 1 1 0 1 1 1 1 CFEM domain Fungal_trans_2 PF11951.8 EFX01783.1 - 0.073 11.9 0.0 0.09 11.6 0.0 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain Pkinase PF00069.25 EFX01784.1 - 3e-63 213.7 0.0 2e-40 138.9 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX01784.1 - 1.8e-34 119.2 0.0 8e-25 87.6 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFX01784.1 - 0.00053 19.4 0.1 0.72 9.1 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFX01784.1 - 0.013 14.2 0.0 0.03 13.1 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EFX01784.1 - 0.02 14.9 0.1 0.082 12.8 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFX01784.1 - 0.15 11.1 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 adh_short_C2 PF13561.6 EFX01785.1 - 5.6e-38 130.8 0.3 1.6e-35 122.8 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01785.1 - 6.3e-30 104.1 2.1 1.1e-25 90.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase Hist_deacetyl PF00850.19 EFX01786.1 - 4.3e-77 259.6 0.0 6.3e-77 259.1 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain SR-25 PF10500.9 EFX01787.1 - 0.13 11.8 7.6 0.19 11.3 7.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIB PF00382.19 EFX01788.1 - 2.1e-30 104.5 0.1 6.4e-17 61.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EFX01788.1 - 2.7e-13 49.2 1.2 2.7e-13 49.2 1.2 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_C PF02984.19 EFX01788.1 - 0.00054 20.0 0.1 0.17 12.0 0.0 2.6 2 1 0 3 3 3 1 Cyclin, C-terminal domain zf-RRN7 PF11781.8 EFX01788.1 - 0.063 13.0 1.4 0.35 10.6 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-piccolo PF05715.13 EFX01788.1 - 0.11 12.6 1.3 7.3 6.8 0.1 3.4 3 1 0 3 3 3 0 Piccolo Zn-finger TMIE PF16038.5 EFX01788.1 - 0.13 12.1 0.3 0.29 11.0 0.3 1.6 1 0 0 1 1 1 0 TMIE protein zf-ribbon_3 PF13248.6 EFX01788.1 - 0.62 9.6 6.9 0.62 9.5 0.0 3.1 3 0 0 3 3 3 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 EFX01788.1 - 0.62 10.1 2.9 4.6 7.3 0.3 2.5 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Ras PF00071.22 EFX01789.1 - 9.6e-51 171.6 0.0 1.1e-50 171.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX01789.1 - 3e-22 79.1 0.0 4.3e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX01789.1 - 6.3e-07 29.0 0.0 9.3e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFX01789.1 - 0.002 17.5 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFX01789.1 - 0.032 13.7 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFX01789.1 - 0.059 13.1 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EFX01789.1 - 0.065 13.3 0.0 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 EFX01789.1 - 0.2 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PXA PF02194.15 EFX01790.1 - 2.1e-48 164.7 0.3 6.6e-48 163.1 0.0 2.1 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EFX01790.1 - 2e-22 79.9 0.0 8e-22 77.9 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EFX01790.1 - 2.9e-19 69.1 0.0 8.1e-19 67.7 0.0 1.8 1 0 0 1 1 1 1 PX domain RGS PF00615.19 EFX01790.1 - 3.6e-10 40.1 0.0 1.2e-09 38.5 0.0 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain HET PF06985.11 EFX01791.1 - 0.0017 18.7 0.1 0.0039 17.6 0.1 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) GMC_oxred_N PF00732.19 EFX01792.1 - 1.6e-58 198.4 0.0 2.9e-58 197.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX01792.1 - 6e-22 78.7 0.0 1.6e-21 77.3 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFX01792.1 - 5.4e-07 29.0 1.0 0.0063 15.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFX01792.1 - 0.00034 20.3 2.9 0.006 16.2 2.8 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX01792.1 - 0.0028 17.8 0.1 0.0066 16.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFX01792.1 - 0.0031 16.6 0.1 0.0055 15.8 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EFX01792.1 - 0.016 14.5 0.1 0.032 13.5 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EFX01792.1 - 0.029 13.6 0.0 0.28 10.4 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX01792.1 - 0.15 10.7 0.1 0.3 9.7 0.1 1.5 2 0 0 2 2 2 0 HI0933-like protein YchF-GTPase_C PF06071.13 EFX01793.1 - 1.9e-37 127.3 0.0 5.1e-37 125.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFX01793.1 - 5.8e-22 77.9 0.0 1.2e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX01793.1 - 6.1e-09 35.6 0.0 1.2e-08 34.7 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 EFX01793.1 - 0.15 12.3 0.0 2.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Aldedh PF00171.22 EFX01794.1 - 4.3e-104 348.6 0.5 5.8e-104 348.2 0.5 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family UbiD PF01977.16 EFX01795.1 - 1.1e-109 367.1 0.0 1.4e-88 297.5 0.0 2.0 1 1 1 2 2 2 2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Fungal_trans PF04082.18 EFX01796.1 - 8.3e-57 192.2 0.3 1.5e-56 191.4 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFX01796.1 - 3.2e-06 27.3 13.9 0.00049 20.4 1.0 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX01796.1 - 0.11 13.4 0.7 0.11 13.4 0.7 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger Ank_2 PF12796.7 EFX01797.1 - 1.9e-16 60.4 3.6 9e-09 35.8 1.1 4.5 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX01797.1 - 1e-11 45.1 4.2 7.2e-07 29.6 0.2 5.7 3 2 2 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX01797.1 - 1.7e-09 37.1 1.5 0.33 11.6 0.0 6.5 6 0 0 6 6 6 1 Ankyrin repeat Ank PF00023.30 EFX01797.1 - 1.2e-07 31.8 10.8 0.1 13.1 0.1 5.9 5 1 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EFX01797.1 - 3.1e-06 27.4 8.1 0.0066 16.7 0.3 5.5 2 2 4 6 6 6 3 Ankyrin repeats (many copies) SNF5 PF04855.12 EFX01798.1 - 1.2e-90 303.5 0.0 1.7e-90 303.0 0.0 1.2 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GalKase_gal_bdg PF10509.9 EFX01798.1 - 2.5e-14 52.5 0.1 5e-14 51.6 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EFX01798.1 - 1.2e-12 47.8 1.4 4.5e-12 46.0 1.4 2.1 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFX01798.1 - 3.8e-11 43.2 0.0 1e-10 41.8 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal DUF3546 PF12066.8 EFX01799.1 - 5.1e-32 110.3 7.9 5.1e-32 110.3 7.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) DUF4187 PF13821.6 EFX01799.1 - 3.5e-11 42.7 0.3 9.3e-11 41.3 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.13 EFX01799.1 - 5.3e-08 33.5 15.7 8.2e-07 29.6 15.7 2.8 1 1 0 1 1 1 1 Arsenite-resistance protein 2 TMF_TATA_bd PF12325.8 EFX01802.1 - 0.017 15.4 0.3 0.025 14.8 0.3 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FlxA PF14282.6 EFX01802.1 - 0.094 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 FlxA-like protein p450 PF00067.22 EFX01803.1 - 1.8e-63 214.9 0.0 1.5e-53 182.2 0.0 2.2 1 1 1 2 2 2 2 Cytochrome P450 Sex_peptide PF08138.11 EFX01803.1 - 2.4 8.4 5.8 15 5.8 5.8 2.2 1 1 0 1 1 1 0 Sex peptide (SP) family Serglycin PF04360.12 EFX01805.1 - 0.033 14.1 0.4 0.34 10.8 0.0 2.4 2 0 0 2 2 2 0 Serglycin U79_P34 PF03064.16 EFX01805.1 - 2 7.7 12.8 0.93 8.8 10.4 1.6 2 0 0 2 2 2 0 HSV U79 / HCMV P34 TMPIT PF07851.13 EFX01805.1 - 6.4 5.9 7.5 11 5.2 7.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein Peptidase_M20 PF01546.28 EFX01806.1 - 4e-27 95.3 0.0 6.7e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX01806.1 - 3.3e-06 27.0 0.0 6.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Ank_4 PF13637.6 EFX01807.1 - 2.5e-20 72.5 2.1 6.7e-11 42.5 0.1 2.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX01807.1 - 1.4e-17 64.0 0.1 1.5e-09 38.3 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFX01807.1 - 1.3e-15 57.3 0.5 1.1e-07 32.0 0.2 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFX01807.1 - 6.6e-15 54.8 0.0 1.7e-07 31.3 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFX01807.1 - 9.3e-13 47.1 0.0 3.6e-05 23.8 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat COesterase PF00135.28 EFX01808.1 - 1.5e-91 307.9 0.0 2.1e-91 307.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX01808.1 - 2.4e-07 30.8 0.4 3e-06 27.3 0.4 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX01808.1 - 0.00073 19.1 0.4 0.0012 18.3 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family EKR PF10371.9 EFX01808.1 - 0.12 12.2 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Glyco_hydro_18 PF00704.28 EFX01809.1 - 5.5e-10 39.5 0.0 4.8e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 Glycosyl hydrolases family 18 OPT PF03169.15 EFX01810.1 - 8.1e-160 533.4 53.0 9.2e-160 533.2 53.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein TspO_MBR PF03073.15 EFX01813.1 - 2e-39 134.7 4.8 2.6e-39 134.4 4.8 1.1 1 0 0 1 1 1 1 TspO/MBR family DUF3123 PF11321.8 EFX01813.1 - 0.23 12.1 4.6 0.46 11.2 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) TauD PF02668.16 EFX01815.1 - 3.6e-43 148.3 0.1 4.9e-43 147.9 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AdoMetDC_leader PF08132.11 EFX01815.1 - 0.031 14.2 1.2 0.073 13.0 1.2 1.5 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide PGM_PMM_I PF02878.16 EFX01816.1 - 3.8e-19 68.8 0.5 3.4e-08 33.3 0.1 3.0 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EFX01816.1 - 4.4e-10 39.6 0.8 2.8e-09 37.0 0.4 2.5 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EFX01816.1 - 0.00063 20.3 0.1 0.26 11.9 0.0 3.0 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFX01816.1 - 0.0029 17.8 0.5 0.0072 16.5 0.1 2.0 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DUF3168 PF11367.8 EFX01816.1 - 0.29 11.3 6.5 9.5 6.4 0.1 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3168) ERCC4 PF02732.15 EFX01817.1 - 6.7e-25 88.1 0.0 1.7e-24 86.8 0.0 1.7 2 0 0 2 2 2 1 ERCC4 domain HHH_8 PF14716.6 EFX01817.1 - 0.0067 16.8 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HTH_27 PF13463.6 EFX01817.1 - 0.069 13.6 0.0 0.22 12.1 0.0 1.9 1 0 0 1 1 1 0 Winged helix DNA-binding domain Cpn60_TCP1 PF00118.24 EFX01818.1 - 2.5e-146 488.2 16.1 2.9e-146 488.0 16.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3599 PF12206.8 EFX01818.1 - 0.17 12.3 0.1 0.37 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3599) Glyco_tranf_2_3 PF13641.6 EFX01819.1 - 2.5e-18 66.8 0.0 4.6e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EFX01819.1 - 7.6e-16 58.6 0.2 7.6e-16 58.6 0.2 2.5 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EFX01819.1 - 8.3e-15 55.0 0.0 1.5e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Cellulose_synt PF03552.14 EFX01819.1 - 2.1e-11 43.1 11.3 8.2e-09 34.5 3.8 3.4 2 1 2 4 4 4 2 Cellulose synthase Glyco_transf_21 PF13506.6 EFX01819.1 - 2.4e-10 40.2 0.0 4.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 EFX01819.1 - 0.0033 16.1 0.6 0.072 11.7 0.2 2.4 2 0 0 2 2 2 1 Chitin synthase PCI PF01399.27 EFX01820.1 - 8.6e-14 51.9 0.0 7.8e-13 48.9 0.0 2.5 3 0 0 3 3 3 1 PCI domain eIF3m_C_helix PF18005.1 EFX01820.1 - 7.2e-13 48.0 3.4 7.2e-13 48.0 3.4 1.7 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix SNO PF01174.19 EFX01821.1 - 9.2e-59 198.5 0.0 1.1e-58 198.2 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EFX01821.1 - 1.2e-10 41.3 0.0 6.3e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 EFX01821.1 - 0.00016 21.5 0.1 0.00026 20.8 0.1 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EFX01821.1 - 0.0003 20.5 0.0 0.0004 20.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 GATase PF00117.28 EFX01821.1 - 0.00081 19.2 0.1 0.0054 16.5 0.1 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase class-I PhoD PF09423.10 EFX01822.1 - 6.4e-06 25.4 0.6 0.0064 15.6 0.0 2.8 3 0 0 3 3 3 2 PhoD-like phosphatase DUF3605 PF12239.8 EFX01824.1 - 5.4e-52 176.2 0.0 7.2e-52 175.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) MFS_1 PF07690.16 EFX01825.1 - 1.6e-57 195.1 35.9 1.3e-51 175.7 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX01825.1 - 5.7e-08 32.1 9.8 5.7e-08 32.1 9.8 3.1 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFX01825.1 - 2.5e-05 22.9 4.1 4.1e-05 22.2 4.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EFX01825.1 - 0.00014 20.3 4.9 0.047 12.0 0.8 2.7 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EFX01825.1 - 0.004 15.6 13.4 0.03 12.7 3.3 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector DUF3439 PF11921.8 EFX01826.1 - 0.019 14.9 0.1 0.019 14.9 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) DSS1_SEM1 PF05160.13 EFX01827.1 - 3.3e-23 81.5 15.8 4.4e-23 81.1 15.8 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.12 EFX01827.1 - 0.12 12.0 8.1 0.13 11.9 8.1 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SH3_1 PF00018.28 EFX01828.1 - 1.8e-11 43.4 0.0 3.1e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFX01828.1 - 9.7e-11 41.4 0.1 1.7e-10 40.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFX01828.1 - 1.3e-10 40.8 0.0 2.2e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PAT1 PF09770.9 EFX01828.1 - 0.26 9.5 9.7 0.33 9.2 9.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HNH_2 PF13391.6 EFX01829.1 - 1.3e-06 28.4 0.1 3e-06 27.3 0.1 1.7 1 0 0 1 1 1 1 HNH endonuclease UPF0016 PF01169.19 EFX01830.1 - 3.6e-38 129.8 22.5 1.7e-20 73.1 6.2 3.2 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 Acetyltransf_3 PF13302.7 EFX01831.1 - 6e-14 52.9 0.0 1e-13 52.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX01831.1 - 2.9e-07 30.7 0.0 4.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EFX01831.1 - 0.014 15.5 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4448 PF14610.6 EFX01832.1 - 0.16 11.7 0.0 0.46 10.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) PEP-CTERM PF07589.11 EFX01832.1 - 1.5 9.0 4.3 5 7.3 3.6 2.2 2 0 0 2 2 2 0 PEP-CTERM motif Acyl-CoA_dh_1 PF00441.24 EFX01833.1 - 4.7e-33 114.5 3.8 9e-33 113.6 3.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFX01833.1 - 1.2e-22 80.7 0.0 2.3e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFX01833.1 - 5e-18 65.1 0.0 8.7e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFX01833.1 - 1.5e-13 51.2 0.5 2.6e-13 50.4 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MmgE_PrpD PF03972.14 EFX01834.1 - 1.4e-146 488.5 0.6 1.8e-146 488.2 0.6 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Fungal_trans PF04082.18 EFX01835.1 - 2.2e-09 36.8 0.1 5.5e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX01835.1 - 6e-05 23.1 11.6 0.00013 22.0 11.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Choline_transpo PF04515.12 EFX01837.1 - 8e-78 261.9 26.7 8e-78 261.9 26.7 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter RNB PF00773.19 EFX01838.1 - 3.1e-95 319.3 0.0 4.5e-95 318.7 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EFX01838.1 - 1.6e-29 102.5 0.0 3.4e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EFX01838.1 - 1.4e-28 98.7 0.0 3.6e-28 97.4 0.0 1.7 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 EFX01838.1 - 8.8e-19 67.3 0.0 2.3e-18 66.0 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EFX01838.1 - 7e-09 36.1 0.0 2.7e-08 34.2 0.0 2.0 2 0 0 2 2 2 1 PIN domain CSD2 PF17876.1 EFX01838.1 - 4.2e-08 33.3 0.0 0.00059 20.0 0.0 3.5 3 0 0 3 3 3 2 Cold shock domain Dis3l2_C_term PF17877.1 EFX01838.1 - 0.032 14.5 0.0 0.084 13.2 0.0 1.7 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal Dyp_perox PF04261.12 EFX01839.1 - 1.8e-87 293.4 0.0 2.3e-87 293.1 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family MARVEL PF01284.23 EFX01841.1 - 0.072 13.1 9.6 0.12 12.4 9.6 1.4 1 0 0 1 1 1 0 Membrane-associating domain DUF1218 PF06749.12 EFX01841.1 - 2.2 8.9 6.7 1.2 9.7 4.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1218) Nefa_Nip30_N PF10187.9 EFX01842.1 - 1.8e-29 102.2 10.4 1.8e-29 102.2 10.4 2.2 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 ICA69 PF04629.14 EFX01842.1 - 0.11 12.9 6.5 0.035 14.4 3.2 1.7 2 0 0 2 2 2 0 Islet cell autoantigen ICA69, C-terminal domain FUSC PF04632.12 EFX01842.1 - 0.4 9.2 2.6 0.51 8.8 2.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family CortBP2 PF09727.9 EFX01842.1 - 4.5 7.2 12.1 1.3 8.9 7.2 1.9 2 0 0 2 2 2 0 Cortactin-binding protein-2 ATP-sulfurylase PF01747.17 EFX01843.1 - 2.8e-87 291.6 0.0 3.9e-87 291.2 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EFX01843.1 - 8.2e-56 188.3 0.0 1.3e-55 187.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EFX01843.1 - 1e-51 174.7 0.0 1.6e-51 174.1 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Glyco_hydro_43 PF04616.14 EFX01844.1 - 1.7e-35 122.8 5.9 2.2e-35 122.4 5.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GN3L_Grn1 PF08701.11 EFX01845.1 - 7.6e-23 80.4 11.1 1.4e-22 79.5 11.1 1.4 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EFX01845.1 - 1.5e-18 66.9 0.3 2.3e-11 43.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFX01845.1 - 1.6e-08 34.8 0.5 0.0054 16.8 0.0 3.5 3 0 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EFX01845.1 - 2.8e-07 30.3 0.0 0.011 15.3 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFX01845.1 - 6.4e-07 29.4 0.0 9e-06 25.7 0.0 2.2 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EFX01845.1 - 1.4e-05 24.7 0.0 0.0074 15.8 0.1 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B MeaB PF03308.16 EFX01845.1 - 0.035 13.1 1.0 0.062 12.3 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EFX01845.1 - 0.062 12.6 0.0 5.1 6.4 0.0 2.3 2 0 0 2 2 2 0 AIG1 family AAA_18 PF13238.6 EFX01845.1 - 0.089 13.3 0.1 0.22 12.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX01845.1 - 0.091 13.1 0.1 0.091 13.1 0.1 3.3 2 1 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 EFX01845.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 EFX01845.1 - 0.15 11.5 0.0 0.47 9.9 0.0 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family bZIP_1 PF00170.21 EFX01847.1 - 2.3e-07 30.8 13.5 4e-07 30.0 13.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 EFX01847.1 - 6.2e-07 29.5 5.5 7.4e-05 22.6 0.0 2.2 1 1 1 2 2 2 1 Transcription factor PAP1 SHE3 PF17078.5 EFX01847.1 - 9.3e-05 22.2 5.9 0.00013 21.7 5.9 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Adaptin_binding PF10199.9 EFX01847.1 - 0.014 16.0 2.1 0.019 15.5 2.1 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 bZIP_Maf PF03131.17 EFX01847.1 - 0.044 14.3 16.9 0.11 13.1 16.7 1.7 1 1 0 1 1 1 0 bZIP Maf transcription factor V_ATPase_I PF01496.19 EFX01847.1 - 0.086 10.7 2.6 0.12 10.3 2.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_2 PF07716.15 EFX01847.1 - 0.4 10.8 17.5 2.4 8.3 15.8 2.3 1 1 1 2 2 2 0 Basic region leucine zipper ADIP PF11559.8 EFX01847.1 - 1.5 8.9 16.2 2.6 8.1 16.2 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding GvpL_GvpF PF06386.11 EFX01847.1 - 3.3 7.6 10.7 5 7.0 10.7 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF FKBP_C PF00254.28 EFX01848.1 - 3.2e-21 75.4 0.1 3.9e-12 46.3 0.1 2.2 1 1 1 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase Cm_res_leader PF08077.11 EFX01848.1 - 0.47 10.7 2.3 13 6.3 0.1 2.9 2 0 0 2 2 2 0 Chloramphenicol resistance gene leader peptide zf-ribbon_3 PF13248.6 EFX01850.1 - 0.46 10.0 5.7 4.7 6.8 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbon domain COesterase PF00135.28 EFX01851.1 - 4.1e-79 266.8 0.1 1.3e-69 235.4 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX01851.1 - 1.2e-08 35.1 0.1 2e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2724 PF10893.8 EFX01852.1 - 0.025 14.4 0.2 0.065 13.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2724) Succ_CoA_lig PF13607.6 EFX01852.1 - 1.3 8.8 4.1 1.1 9.0 1.1 2.2 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain OrfB_Zn_ribbon PF07282.11 EFX01854.1 - 0.018 14.9 3.7 0.047 13.6 3.7 1.7 1 1 0 1 1 1 0 Putative transposase DNA-binding domain FYDLN_acid PF09538.10 EFX01854.1 - 0.088 13.5 0.5 0.13 13.0 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Fumerase_C PF05683.12 EFX01854.1 - 0.21 10.9 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Fumarase C-terminus Zn-ribbon_8 PF09723.10 EFX01854.1 - 0.32 11.2 3.7 1.9 8.7 3.7 2.2 1 1 0 1 1 1 0 Zinc ribbon domain Dynactin_p22 PF07426.11 EFX01855.1 - 8.6e-08 32.2 0.0 2.9e-07 30.5 0.0 1.7 1 1 1 2 2 2 1 Dynactin subunit p22 APG6_N PF17675.1 EFX01855.1 - 0.0065 17.0 0.2 0.029 14.9 0.0 2.0 1 1 1 2 2 2 1 Apg6 coiled-coil region ACP_PD PF04336.12 EFX01855.1 - 0.0069 16.8 1.1 0.023 15.1 0.6 2.1 2 1 1 3 3 3 1 Acyl carrier protein phosphodiesterase Snf7 PF03357.21 EFX01855.1 - 0.015 14.9 2.1 0.022 14.4 2.1 1.2 1 0 0 1 1 1 0 Snf7 CENP-F_leu_zip PF10473.9 EFX01855.1 - 0.03 14.4 2.4 0.054 13.5 2.4 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 EFX01855.1 - 0.064 13.0 3.3 1.6 8.5 0.2 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF4140 PF13600.6 EFX01855.1 - 0.077 13.4 0.2 0.077 13.4 0.2 2.8 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Snapin_Pallidin PF14712.6 EFX01855.1 - 0.093 13.2 2.3 0.6 10.6 2.3 2.2 1 1 0 1 1 1 0 Snapin/Pallidin Osmo_CC PF08946.10 EFX01855.1 - 0.18 12.1 1.6 0.39 11.0 0.2 2.2 2 0 0 2 2 2 0 Osmosensory transporter coiled coil COG2 PF06148.11 EFX01855.1 - 0.35 11.0 1.9 0.85 9.7 1.8 1.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TMF_TATA_bd PF12325.8 EFX01855.1 - 3.1 8.0 10.1 5.1 7.4 6.8 2.7 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding HalX PF08663.10 EFX01855.1 - 8.3 6.8 14.9 1.2 9.5 1.7 3.5 3 1 1 4 4 4 0 HalX domain Glyco_trans_2_3 PF13632.6 EFX01856.1 - 7.8e-51 172.8 3.9 7.8e-51 172.8 3.9 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EFX01856.1 - 5.7e-06 26.2 0.0 2.4e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFX01856.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFX01856.1 - 0.018 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 NAC PF01849.18 EFX01857.1 - 2.4e-23 81.9 0.6 6.9e-23 80.4 0.1 1.9 2 0 0 2 2 2 1 NAC domain MAGI_u1 PF16663.5 EFX01857.1 - 0.03 14.4 0.2 0.088 12.9 0.0 1.9 2 0 0 2 2 2 0 Unstructured region on MAGI Abhydrolase_1 PF00561.20 EFX01858.1 - 4.9e-25 88.6 0.3 8.2e-25 87.9 0.3 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EFX01858.1 - 1.6e-18 66.0 0.5 3.3e-18 65.0 0.0 1.9 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region FSH1 PF03959.13 EFX01858.1 - 0.0028 17.3 0.1 0.64 9.6 0.0 2.5 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Thioredox_DsbH PF03190.15 EFX01859.1 - 1.9e-58 197.1 0.0 3.7e-58 196.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EFX01859.1 - 9.8e-06 25.7 0.0 2.2e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_76 PF03663.14 EFX01859.1 - 0.01 15.4 0.0 0.068 12.7 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 76 HTH_10 PF04967.12 EFX01859.1 - 0.097 12.5 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 HTH DNA binding domain Glyco_hydro_127 PF07944.12 EFX01859.1 - 0.14 10.6 0.0 0.28 9.6 0.0 1.4 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 HTH_7 PF02796.15 EFX01859.1 - 0.16 12.0 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Phage_pRha PF09669.10 EFX01859.1 - 0.2 12.3 0.0 1.8 9.1 0.0 2.2 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Rsm22 PF09243.10 EFX01860.1 - 2.2e-32 112.5 0.0 1.7e-19 70.2 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 Thioredoxin PF00085.20 EFX01860.1 - 7.2e-29 99.8 0.0 1.2e-28 99.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFX01860.1 - 2.1e-07 31.4 0.0 5.8e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EFX01860.1 - 3.7e-06 26.5 0.0 6.3e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFX01860.1 - 0.00011 22.5 0.0 0.00085 19.6 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EFX01860.1 - 0.0024 17.6 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Methyltransf_23 PF13489.6 EFX01860.1 - 0.0047 16.8 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Redoxin PF08534.10 EFX01860.1 - 0.01 15.6 0.1 1.7 8.3 0.0 2.3 1 1 1 2 2 2 0 Redoxin AhpC-TSA PF00578.21 EFX01860.1 - 0.022 14.7 0.1 1.5 8.7 0.0 2.4 1 1 0 2 2 2 0 AhpC/TSA family SelK_SelG PF10961.8 EFX01860.1 - 0.033 14.8 0.7 0.033 14.8 0.7 2.7 2 1 1 3 3 3 0 Selenoprotein SelK_SelG HyaE PF07449.11 EFX01860.1 - 0.065 13.2 0.0 0.22 11.5 0.0 1.9 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EFX01860.1 - 0.19 12.0 0.0 0.52 10.5 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like adh_short_C2 PF13561.6 EFX01861.1 - 5.9e-56 189.6 1.3 1.1e-55 188.8 1.3 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01861.1 - 1e-46 158.9 2.9 1.7e-46 158.2 2.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01861.1 - 4e-13 49.7 0.7 6.2e-13 49.1 0.7 1.2 1 0 0 1 1 1 1 KR domain DUF1372 PF07116.11 EFX01861.1 - 0.12 12.5 0.0 0.49 10.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1372) SNase PF00565.17 EFX01862.1 - 6.8e-71 235.6 0.2 1.5e-21 76.8 0.0 5.6 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EFX01862.1 - 1e-22 80.5 0.0 2.3e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EFX01862.1 - 0.0002 20.7 0.0 0.00046 19.5 0.0 1.5 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Agenet PF05641.12 EFX01862.1 - 0.065 13.7 0.3 0.34 11.4 0.1 2.4 2 0 0 2 2 2 0 Agenet domain Aa_trans PF01490.18 EFX01864.1 - 7.5e-90 301.6 19.3 1e-89 301.1 19.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EFX01864.1 - 0.00058 19.0 20.5 0.001 18.2 20.5 1.5 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Abhydrolase_9_N PF15420.6 EFX01864.1 - 0.013 15.5 2.4 0.013 15.5 2.4 2.6 3 0 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus Phage_base_V PF04717.12 EFX01864.1 - 0.052 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Type VI secretion system, phage-baseplate injector SSF PF00474.17 EFX01865.1 - 5.5e-18 65.0 29.5 9.7e-18 64.2 29.5 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family Abhydrolase_1 PF00561.20 EFX01866.1 - 4.6e-43 147.7 0.0 1.9e-42 145.7 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EFX01866.1 - 5.5e-05 22.9 0.0 9.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase PAP_assoc PF03828.19 EFX01867.1 - 3e-18 65.8 0.1 1.2e-17 63.9 0.1 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFX01867.1 - 1e-06 28.9 0.0 2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFX01867.1 - 0.0037 17.3 0.0 0.0066 16.5 0.0 1.4 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase CCDC-167 PF15188.6 EFX01867.1 - 0.33 11.3 1.7 0.7 10.3 1.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Metallophos PF00149.28 EFX01868.1 - 3.9e-07 30.8 0.0 1.6e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFX01868.1 - 0.00015 22.0 0.0 0.0004 20.6 0.0 1.8 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RRM_1 PF00076.22 EFX01871.1 - 6.3e-14 51.5 0.0 9.5e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFX01871.1 - 0.007 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pirin PF02678.16 EFX01872.1 - 7.6e-26 90.2 0.3 3.7e-25 88.0 0.3 1.9 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.11 EFX01872.1 - 0.0002 21.0 1.6 0.004 16.8 0.8 2.9 2 1 0 2 2 2 1 Cupin domain Gpr1_Fun34_YaaH PF01184.19 EFX01874.1 - 7e-91 303.4 20.4 8.2e-91 303.2 20.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family PHD PF00628.29 EFX01875.1 - 1.9e-09 37.3 1.7 4.1e-09 36.2 1.7 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EFX01875.1 - 0.0096 15.5 2.7 0.017 14.7 2.7 1.4 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 EFX01875.1 - 0.093 12.8 1.6 0.19 11.7 1.6 1.5 1 0 0 1 1 1 0 CW-type Zinc Finger NAR PF16251.5 EFX01877.1 - 0.11 13.2 0.0 0.11 13.2 0.0 1.1 1 0 0 1 1 1 0 Nucleic acid-binding domain (NAR) Cas_CXXC_CXXC PF09706.10 EFX01877.1 - 0.22 11.8 0.0 0.3 11.4 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) Romo1 PF10247.9 EFX01878.1 - 9e-28 96.4 13.8 1.3e-27 95.9 13.8 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 EFX01878.1 - 0.00026 21.3 2.6 0.00028 21.2 2.6 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_OmpA PF13436.6 EFX01878.1 - 0.075 12.8 4.3 0.45 10.3 0.8 2.5 2 0 0 2 2 2 0 Glycine-zipper domain Chorion_2 PF03964.15 EFX01880.1 - 0.0069 17.2 1.8 0.018 15.8 1.8 1.7 1 0 0 1 1 1 1 Chorion family 2 Herpes_capsid PF06112.11 EFX01880.1 - 0.03 14.4 2.2 0.059 13.4 2.2 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SR-25 PF10500.9 EFX01880.1 - 8.9 5.9 11.1 13 5.3 11.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_16 PF00722.21 EFX01881.1 - 3.2e-15 56.0 2.3 6.5e-15 55.0 2.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 TaqI_C PF12950.7 EFX01881.1 - 0.039 14.0 0.0 0.2 11.7 0.0 2.0 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain Memo PF01875.17 EFX01882.1 - 3.7e-68 229.6 0.0 4.4e-68 229.4 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Adaptin_N PF01602.20 EFX01883.1 - 3.2e-112 375.8 0.1 4.2e-112 375.4 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EFX01883.1 - 1.2e-55 187.8 3.7 2.6e-55 186.7 3.7 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EFX01883.1 - 3.4e-35 120.6 0.1 1.1e-34 119.1 0.1 1.9 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EFX01883.1 - 1.8e-17 63.5 1.0 2.7e-12 46.9 0.1 5.0 3 1 2 5 5 5 2 HEAT repeats Cnd1 PF12717.7 EFX01883.1 - 7.2e-06 26.1 8.7 0.06 13.4 0.1 4.8 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EFX01883.1 - 0.0021 18.2 0.4 3.3 7.9 0.0 3.6 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 EFX01883.1 - 0.0074 16.9 1.3 6.6 7.7 0.0 4.7 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat HEAT PF02985.22 EFX01883.1 - 0.1 12.9 6.2 4.3 7.8 0.4 4.7 4 0 0 4 4 4 0 HEAT repeat Lyase_8 PF02278.18 EFX01883.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain CLASP_N PF12348.8 EFX01883.1 - 0.32 10.5 5.2 0.4 10.2 0.1 3.1 4 0 0 4 4 4 0 CLASP N terminal HEAT_EZ PF13513.6 EFX01883.1 - 2.6 8.6 4.4 1.6 9.4 0.6 2.7 2 1 1 3 3 3 0 HEAT-like repeat FSH1 PF03959.13 EFX01884.1 - 1.6e-56 191.3 0.0 2.4e-56 190.7 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) ATP-synt_J PF04911.12 EFX01884.1 - 2.1e-21 75.3 0.6 4.2e-21 74.3 0.6 1.5 1 0 0 1 1 1 1 ATP synthase j chain Hydrolase_4 PF12146.8 EFX01884.1 - 0.0021 17.4 0.1 0.14 11.4 0.0 2.4 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EFX01884.1 - 0.033 14.0 0.0 6 6.6 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Esterase_phd PF10503.9 EFX01884.1 - 0.035 13.6 1.1 5.7 6.4 0.0 2.3 1 1 1 2 2 2 0 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 EFX01884.1 - 0.035 13.8 0.7 4.9 6.7 0.3 2.4 1 1 1 2 2 2 0 alpha/beta hydrolase fold DLH PF01738.18 EFX01884.1 - 0.13 11.8 0.0 5.5 6.5 0.0 2.4 2 0 0 2 2 2 0 Dienelactone hydrolase family BAAT_C PF08840.11 EFX01884.1 - 0.19 11.6 0.1 1.7 8.5 0.0 2.4 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.20 EFX01884.1 - 0.31 10.6 1.8 4.6 6.8 1.4 2.2 1 1 0 2 2 2 0 Putative esterase MFS_1 PF07690.16 EFX01885.1 - 2.8e-42 144.9 31.2 2.1e-40 138.7 17.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Wbp11 PF09429.10 EFX01885.1 - 4.8e-22 78.1 5.3 1.2e-21 76.9 5.3 1.7 1 0 0 1 1 1 1 WW domain binding protein 11 Sugar_tr PF00083.24 EFX01885.1 - 5.3e-09 35.4 0.2 5.3e-09 35.4 0.2 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter zf-met PF12874.7 EFX01886.1 - 3.3e-06 27.3 1.2 0.0003 21.1 0.3 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFX01886.1 - 3.9e-06 27.0 0.4 0.00038 20.6 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFX01886.1 - 8.3e-06 26.2 8.1 0.011 16.5 0.3 2.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EFX01886.1 - 1.7e-05 25.1 0.8 0.00063 20.0 0.2 2.0 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EFX01886.1 - 2.7e-05 24.1 2.2 4.3e-05 23.4 0.7 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EFX01886.1 - 0.00012 22.4 5.4 0.012 16.0 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf_ZIC PF18366.1 EFX01886.1 - 0.036 14.2 0.2 9.6 6.4 0.2 2.2 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-H2C2_2 PF13465.6 EFX01886.1 - 0.072 13.6 3.4 4.1 8.0 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger double domain ABM PF03992.16 EFX01886.1 - 0.19 11.9 0.0 2.7 8.2 0.0 2.1 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase Zn-ribbon_8 PF09723.10 EFX01886.1 - 0.39 10.9 4.8 1.4 9.1 1.2 2.4 1 1 1 2 2 2 0 Zinc ribbon domain CHCH PF06747.13 EFX01888.1 - 3.3e-08 33.5 11.6 4.3e-06 26.7 6.1 2.4 2 0 0 2 2 2 2 CHCH domain CX9C PF16860.5 EFX01888.1 - 4.3e-06 26.6 6.6 0.0015 18.4 3.1 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EFX01888.1 - 0.0031 17.5 8.0 0.39 10.8 2.6 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 EFX01888.1 - 0.13 12.6 6.2 1.4 9.2 1.4 2.7 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 EFX01888.1 - 1.5 9.1 9.3 2.6 8.3 3.4 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb zf-C3H1 PF10650.9 EFX01889.1 - 1.9e-07 30.7 0.2 3e-07 30.0 0.2 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain Rotamase_2 PF13145.6 EFX01890.1 - 2.1 9.2 6.4 0.45 11.4 0.6 2.3 2 0 0 2 2 2 0 PPIC-type PPIASE domain SnoaL_2 PF12680.7 EFX01891.1 - 2.6e-07 31.2 0.0 3.2e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 EFX01891.1 - 6.5e-07 29.5 0.1 9.1e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 EFX01891.1 - 7.1e-07 29.5 0.1 8.6e-07 29.2 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFX01891.1 - 0.00018 21.8 0.0 0.00023 21.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) NTF2 PF02136.20 EFX01891.1 - 0.0003 21.4 0.0 0.00049 20.7 0.0 1.4 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Kunitz_legume PF00197.18 EFX01891.1 - 0.0058 16.6 0.0 0.0074 16.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin and protease inhibitor Imm-NTF2 PF15655.6 EFX01891.1 - 0.0082 16.4 0.0 0.044 14.1 0.1 1.9 1 1 0 2 2 2 1 NTF2 fold immunity protein SnoaL PF07366.12 EFX01891.1 - 0.013 15.3 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase ketoacyl-synt PF00109.26 EFX01892.1 - 1e-60 205.4 0.7 3.2e-32 112.1 0.4 2.5 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EFX01892.1 - 1.2e-55 188.2 0.0 9e-55 185.4 0.0 2.4 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFX01892.1 - 5.2e-48 163.8 0.0 1e-47 162.8 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFX01892.1 - 3.4e-45 154.9 0.1 8.7e-45 153.6 0.1 1.5 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFX01892.1 - 2.5e-20 72.7 0.1 4.4e-17 62.2 0.0 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFX01892.1 - 1.2e-13 51.5 0.1 3.2e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFX01892.1 - 1.8e-13 50.4 0.0 5.4e-12 45.6 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 EFX01892.1 - 5e-08 33.0 1.7 3.1e-07 30.4 0.0 3.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EFX01892.1 - 1.9e-06 27.6 0.0 4.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EFX01892.1 - 0.00078 19.7 0.1 0.0023 18.3 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EFX01892.1 - 0.095 12.0 0.2 0.22 10.8 0.2 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain NUDIX PF00293.28 EFX01893.1 - 7.4e-15 55.2 0.0 1.1e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Abhydrolase_1 PF00561.20 EFX01894.1 - 1.5e-06 28.1 0.3 4.4e-06 26.5 0.3 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX01894.1 - 7.8e-05 23.4 6.3 7.8e-05 23.4 6.3 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EFX01894.1 - 0.0073 16.2 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EFX01894.1 - 0.035 14.2 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain DUF1018 PF06252.12 EFX01894.1 - 0.12 13.4 0.0 0.23 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Glyco_hydro_3_C PF01915.22 EFX01895.1 - 5.2e-45 153.9 0.1 1.7e-44 152.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX01895.1 - 2.9e-39 135.3 0.0 4.2e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX01895.1 - 3.7e-20 71.8 0.1 7.2e-20 70.9 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain adh_short_C2 PF13561.6 EFX01896.1 - 4.3e-45 154.1 2.7 1.6e-44 152.2 2.7 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01896.1 - 1.8e-27 96.1 2.7 6.3e-27 94.3 2.7 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01896.1 - 2.5e-07 30.8 0.7 6.7e-07 29.4 0.7 1.7 1 1 0 1 1 1 1 KR domain RNA12 PF10443.9 EFX01896.1 - 0.12 11.0 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 RNA12 protein Epimerase PF01370.21 EFX01896.1 - 0.22 11.0 0.9 0.85 9.0 0.9 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF3433 PF11915.8 EFX01897.1 - 4.5e-26 91.1 20.8 1.2e-25 89.7 6.6 3.5 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) Ribosomal_S5 PF00333.20 EFX01898.1 - 2.1e-27 94.9 1.0 5.1e-27 93.6 1.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFX01898.1 - 6.6e-23 80.0 0.0 1.1e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EFX01898.1 - 3 8.5 15.0 6.6 7.4 15.0 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Cu-oxidase_2 PF07731.14 EFX01899.1 - 8.3e-40 135.7 4.2 1e-39 135.4 0.3 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EFX01899.1 - 1.4e-34 119.6 0.1 1.8e-32 112.7 0.0 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFX01899.1 - 1e-27 96.5 3.2 4.9e-25 87.8 1.0 2.9 3 0 0 3 3 3 2 Multicopper oxidase FMO-like PF00743.19 EFX01899.1 - 4e-26 91.5 0.0 1.4e-15 56.8 0.0 2.3 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX01899.1 - 3.1e-07 30.0 0.0 1.7e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX01899.1 - 0.0002 20.6 0.0 0.042 13.0 0.0 2.9 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFX01899.1 - 0.003 16.8 0.0 0.021 14.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_7 PF00840.20 EFX01900.1 - 3.2e-194 645.7 23.1 3.6e-194 645.5 23.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 ABC1 PF03109.16 EFX01901.1 - 4.2e-22 78.5 0.0 8.8e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 EFX01901.1 - 0.0026 17.7 0.3 0.0074 16.2 0.3 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family YpsA PF06908.11 EFX01901.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 YspA SLOG family SLC35F PF06027.12 EFX01902.1 - 5.4e-94 315.1 18.6 6.5e-94 314.8 18.6 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EFX01902.1 - 6.8e-09 35.1 1.9 6.8e-09 35.1 1.9 1.6 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EFX01902.1 - 7.8e-07 29.3 33.2 0.0017 18.5 11.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 EFX01902.1 - 1.3 8.0 4.6 0.31 10.1 0.4 2.0 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS DUF2721 PF11026.8 EFX01902.1 - 7.4 6.5 10.9 0.051 13.5 1.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) Bax1-I PF01027.20 EFX01903.1 - 1.9e-52 178.1 26.3 2.2e-52 177.9 26.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 TMEM171 PF15471.6 EFX01903.1 - 0.75 8.7 2.2 4.7 6.1 0.1 2.2 2 0 0 2 2 2 0 Transmembrane protein family 171 Amidohydro_1 PF01979.20 EFX01904.1 - 2.6e-27 96.1 0.1 2.2e-26 93.0 0.1 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX01904.1 - 2.7e-11 43.6 4.9 1.8e-05 24.4 0.8 2.4 1 1 1 2 2 2 2 Amidohydrolase family Gln-synt_C PF00120.24 EFX01905.1 - 7.2e-61 206.1 0.0 6.5e-30 104.3 0.0 2.1 1 1 1 2 2 2 2 Glutamine synthetase, catalytic domain Methyltransf_25 PF13649.6 EFX01905.1 - 1.6e-09 38.4 0.0 4.6e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX01905.1 - 3.1e-09 37.4 0.0 7.1e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX01905.1 - 0.00013 22.7 0.0 0.00024 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX01905.1 - 0.002 18.0 0.0 0.0041 17.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX01905.1 - 0.005 16.6 0.0 0.0093 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain WD40 PF00400.32 EFX01906.1 - 4.5e-18 65.3 9.8 0.00068 20.4 0.0 8.2 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01906.1 - 7.5e-08 32.6 0.0 0.26 11.6 0.1 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX01906.1 - 0.084 11.8 0.5 1.4 7.9 0.0 3.0 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RRM_1 PF00076.22 EFX01907.1 - 2.4e-13 49.7 0.0 8.2e-13 48.0 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFX01907.1 - 0.01 16.0 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif MIP PF00230.20 EFX01908.1 - 2.7e-51 174.5 14.3 3.4e-51 174.1 14.3 1.0 1 0 0 1 1 1 1 Major intrinsic protein G-patch PF01585.23 EFX01910.1 - 1.7e-09 37.4 1.6 3.1e-09 36.6 1.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFX01910.1 - 2.7e-05 24.1 1.4 6.7e-05 22.9 1.4 1.6 1 0 0 1 1 1 1 G-patch domain zf-C2H2_2 PF12756.7 EFX01910.1 - 0.0016 18.7 0.1 0.26 11.7 0.0 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EFX01910.1 - 0.005 17.1 0.0 1.5 9.2 0.1 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EFX01910.1 - 0.034 15.0 3.2 5.1 8.2 0.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger FAA_hydro_N_2 PF18288.1 EFX01910.1 - 0.04 14.3 0.2 0.26 11.7 0.1 2.5 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 zf-met PF12874.7 EFX01910.1 - 0.15 12.5 0.1 5.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RED_N PF07808.13 EFX01910.1 - 1.6 8.3 6.4 0.069 12.7 0.4 1.7 2 0 0 2 2 2 0 RED-like protein N-terminal region MFS_1 PF07690.16 EFX01911.1 - 2e-33 115.8 55.6 6e-31 107.6 26.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX01911.1 - 1.1e-07 31.1 5.8 1.1e-07 31.1 5.8 2.8 2 2 2 4 4 4 2 Sugar (and other) transporter MFS_3 PF05977.13 EFX01911.1 - 0.00015 20.3 11.1 0.00056 18.4 4.4 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 EFX01911.1 - 0.2 10.5 11.0 0.047 12.5 3.6 2.5 3 0 0 3 3 3 0 MFS_1 like family PAPS_reduct PF01507.19 EFX01912.1 - 7.4e-39 133.6 0.0 1e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family GGACT PF06094.12 EFX01912.1 - 0.0012 19.4 0.1 0.0019 18.8 0.1 1.4 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Phage_int_SAM_1 PF02899.17 EFX01912.1 - 0.084 13.2 0.1 0.94 9.8 0.0 2.6 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Rpp20 PF12328.8 EFX01913.1 - 6.1e-19 68.3 0.0 1.1e-18 67.5 0.0 1.4 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EFX01913.1 - 5.5e-10 38.9 0.0 1e-09 38.1 0.0 1.4 1 1 0 1 1 1 1 Alba CDP-OH_P_transf PF01066.21 EFX01914.1 - 4.7e-18 65.7 0.1 4.7e-18 65.7 0.1 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TetM_leader PF08076.11 EFX01915.1 - 0.042 13.6 0.1 0.088 12.6 0.1 1.5 1 0 0 1 1 1 0 Tetracycline resistance determinant leader peptide Peptidase_C1_2 PF03051.15 EFX01916.1 - 7.6e-53 179.8 0.0 3.4e-48 164.5 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family M20_dimer PF07687.14 EFX01917.1 - 1.5e-05 24.9 0.0 1.9e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase dimerisation domain Cm_res_leader PF08077.11 EFX01917.1 - 0.087 12.9 0.9 0.68 10.2 0.3 2.4 2 0 0 2 2 2 0 Chloramphenicol resistance gene leader peptide zf-C2H2_10 PF16588.5 EFX01918.1 - 0.01 15.5 4.0 0.024 14.3 4.0 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger SUIM_assoc PF16619.5 EFX01918.1 - 1.4 9.1 3.5 1.3 9.1 0.3 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-CCHC PF00098.23 EFX01918.1 - 1.4 9.1 6.8 2.4 8.4 2.0 2.5 2 0 0 2 2 2 0 Zinc knuckle Cu-oxidase_3 PF07732.15 EFX01919.1 - 1.4e-45 154.1 5.8 1.8e-43 147.3 0.5 3.0 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX01919.1 - 6.3e-34 116.7 7.9 2.4e-32 111.5 1.4 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX01919.1 - 4.5e-25 88.6 0.0 1.7e-24 86.7 0.0 1.9 2 0 0 2 2 2 1 Multicopper oxidase A2M PF00207.22 EFX01920.1 - 0.042 13.7 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 Alpha-2-macroglobulin family SPX PF03105.19 EFX01920.1 - 0.55 10.1 7.2 0.59 10.0 6.3 1.5 1 1 0 1 1 1 0 SPX domain Macoilin PF09726.9 EFX01920.1 - 1.9 6.9 11.6 2.7 6.4 11.6 1.1 1 0 0 1 1 1 0 Macoilin family MFS_1 PF07690.16 EFX01921.1 - 3.4e-18 65.7 38.1 1e-17 64.2 37.5 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX01921.1 - 1.3e-06 27.2 12.7 1.6e-06 26.9 12.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3483 PF11982.8 EFX01921.1 - 5 6.7 7.8 0.67 9.5 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) GDC-P PF02347.16 EFX01922.1 - 8.1e-178 591.6 0.0 4.1e-165 549.8 0.0 2.4 2 1 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 EFX01922.1 - 4.8e-05 22.8 0.0 0.00015 21.1 0.0 1.7 2 0 0 2 2 2 1 Beta-eliminating lyase DUF3399 PF11879.8 EFX01923.1 - 0.0084 16.4 0.1 0.02 15.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) Gly-zipper_YMGG PF13441.6 EFX01925.1 - 0.41 10.4 6.4 0.43 10.4 4.7 1.8 2 0 0 2 2 2 0 YMGG-like Gly-zipper ERCC4 PF02732.15 EFX01926.1 - 2.4e-17 63.6 0.0 4.4e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain DUF4780 PF16012.5 EFX01926.1 - 0.1 12.0 0.0 11 5.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4780) HHH_5 PF14520.6 EFX01926.1 - 0.15 12.7 0.0 0.37 11.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain FHA PF00498.26 EFX01927.1 - 5.3e-17 61.9 0.1 1.7e-16 60.3 0.1 2.0 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFX01927.1 - 0.00036 20.8 0.5 0.0019 18.5 0.0 2.3 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Citrate_synt PF00285.21 EFX01928.1 - 1.1e-98 330.7 0.0 1.3e-98 330.4 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain COX16 PF14138.6 EFX01929.1 - 5.4e-33 113.3 0.1 7.8e-33 112.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 HAD PF12710.7 EFX01931.1 - 2.9e-23 83.3 0.3 5.5e-23 82.3 0.3 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFX01931.1 - 6.1e-13 49.5 2.1 2.3e-12 47.7 2.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFX01931.1 - 3.8e-09 36.7 0.2 3.2e-08 33.6 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF705 PF05152.12 EFX01931.1 - 0.0061 16.1 0.0 0.0086 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) HAD_2 PF13419.6 EFX01931.1 - 0.034 14.2 0.0 0.58 10.2 0.0 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EFX01931.1 - 0.055 13.3 0.0 0.19 11.6 0.0 1.9 1 1 0 1 1 1 0 Acid Phosphatase Put_Phosphatase PF06888.12 EFX01931.1 - 0.16 11.4 0.1 11 5.4 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase TFIIS_C PF01096.18 EFX01932.1 - 8.5e-19 67.1 2.1 8.5e-19 67.1 2.1 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EFX01932.1 - 3.1e-07 30.2 5.2 4e-07 29.8 1.0 2.5 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Elf1 PF05129.13 EFX01932.1 - 0.01 15.8 5.7 0.11 12.6 0.3 2.5 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like Zn_ribbon_recom PF13408.6 EFX01932.1 - 0.036 14.6 0.2 0.036 14.6 0.2 2.4 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.7 EFX01932.1 - 0.045 13.7 7.2 0.62 10.1 2.0 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain IBR PF01485.21 EFX01932.1 - 0.051 13.8 7.9 2.1 8.6 2.0 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-H2C2_2 PF13465.6 EFX01932.1 - 0.44 11.1 5.4 5.6 7.6 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double domain DUF2387 PF09526.10 EFX01932.1 - 1.5 9.1 7.7 0.26 11.4 0.8 2.2 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) Pectate_lyase_3 PF12708.7 EFX01933.1 - 5.9e-64 215.8 8.4 3e-49 167.8 0.5 3.8 2 1 1 3 3 3 3 Pectate lyase superfamily protein End_N_terminal PF12218.8 EFX01933.1 - 0.017 14.8 0.1 0.041 13.6 0.1 1.6 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase CBP4 PF07960.11 EFX01934.1 - 1.8e-29 102.2 2.0 2.7e-29 101.7 2.0 1.2 1 0 0 1 1 1 1 CBP4 Succ_CoA_lig PF13607.6 EFX01934.1 - 0.014 15.2 0.3 0.017 14.9 0.3 1.1 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain IFT46_B_C PF12317.8 EFX01934.1 - 0.037 13.7 0.8 0.042 13.6 0.8 1.1 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal FAM212 PF15342.6 EFX01934.1 - 0.064 13.0 0.4 0.12 12.2 0.4 1.4 1 0 0 1 1 1 0 FAM212 family RIB43A PF05914.12 EFX01934.1 - 0.078 11.7 10.0 0.095 11.4 10.0 1.0 1 0 0 1 1 1 0 RIB43A Nbs1_C PF08599.10 EFX01934.1 - 0.18 12.0 2.4 0.37 11.0 0.0 2.4 1 1 2 3 3 3 0 DNA damage repair protein Nbs1 Tmemb_161AB PF10268.9 EFX01934.1 - 0.2 10.3 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB PET117 PF15786.5 EFX01934.1 - 3.1 8.1 7.2 0.28 11.5 0.7 2.1 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial Choline_kinase PF01633.20 EFX01935.1 - 3e-58 196.9 0.0 7.5e-58 195.6 0.0 1.7 2 1 0 2 2 2 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EFX01935.1 - 1.5e-20 72.6 0.0 2.9e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EFX01935.1 - 1.9e-06 28.0 0.6 4.7e-06 26.7 0.6 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Collagen PF01391.18 EFX01935.1 - 0.0015 18.3 5.7 0.003 17.3 5.7 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) EccE PF11203.8 EFX01935.1 - 1.1 9.7 5.2 2.1 8.7 0.1 3.6 2 2 2 4 4 4 0 Putative type VII ESX secretion system translocon, EccE Calpain_inhib PF00748.19 EFX01935.1 - 2.1 8.8 6.5 0.53 10.8 2.3 2.2 2 0 0 2 2 2 0 Calpain inhibitor TAL_FSA PF00923.19 EFX01936.1 - 1.1e-94 317.0 1.2 1.3e-94 316.8 1.2 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase adh_short_C2 PF13561.6 EFX01937.1 - 4.3e-38 131.2 1.2 8.1e-38 130.3 1.2 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01937.1 - 4.9e-36 124.0 0.3 7.1e-36 123.5 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01937.1 - 2.7e-10 40.4 2.2 2.9e-09 37.1 0.4 2.2 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EFX01937.1 - 0.00075 18.7 0.0 0.001 18.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFX01937.1 - 0.0018 17.8 0.2 0.016 14.7 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 EFX01937.1 - 0.0023 17.3 0.1 0.0036 16.7 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EFX01937.1 - 0.0056 16.6 0.3 0.016 15.1 0.3 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1776 PF08643.10 EFX01937.1 - 0.02 14.3 0.0 0.028 13.8 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Med31 PF05669.12 EFX01938.1 - 1e-35 121.6 2.4 1.2e-35 121.3 2.4 1.0 1 0 0 1 1 1 1 SOH1 SUR7 PF06687.12 EFX01939.1 - 1.5e-22 80.3 14.5 2.4e-22 79.6 14.5 1.2 1 0 0 1 1 1 1 SUR7/PalI family CorA PF01544.18 EFX01941.1 - 3.4e-13 49.6 0.1 5.9e-13 48.8 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DDE_Tnp_ISL3 PF01610.17 EFX01941.1 - 0.014 15.1 0.2 0.028 14.2 0.2 1.5 1 0 0 1 1 1 0 Transposase WD40 PF00400.32 EFX01942.1 - 1.3e-06 29.0 0.1 0.047 14.6 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX01942.1 - 0.00075 19.8 0.0 0.0076 16.5 0.0 2.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 EFX01942.1 - 0.017 14.9 1.6 0.39 10.4 0.2 2.3 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Ge1_WD40 PF16529.5 EFX01942.1 - 0.028 13.4 0.1 1.1 8.1 0.1 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Flavoprotein PF02441.19 EFX01942.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Flavoprotein Phosphodiest PF01663.22 EFX01943.1 - 7.9e-92 308.6 0.8 7.9e-92 308.6 0.8 1.4 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase RCR PF12273.8 EFX01943.1 - 0.082 13.6 1.8 0.9 10.2 0.0 2.6 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red PglZ PF08665.12 EFX01943.1 - 0.14 12.2 0.7 0.3 11.2 0.0 1.8 2 0 0 2 2 2 0 PglZ domain Sulfatase PF00884.23 EFX01943.1 - 0.2 11.0 8.9 0.23 10.8 0.0 2.6 3 0 0 3 3 3 0 Sulfatase ABC_tran PF00005.27 EFX01944.1 - 2.4e-50 170.6 0.1 6e-27 94.8 0.0 3.9 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFX01944.1 - 4.4e-14 53.0 6.0 0.00018 21.4 0.5 4.3 2 2 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX01944.1 - 1.5e-12 47.4 1.0 0.0016 18.0 0.1 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFX01944.1 - 3.2e-09 37.6 0.3 0.00026 21.6 0.0 3.0 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EFX01944.1 - 7.9e-09 35.6 0.0 0.0038 17.3 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFX01944.1 - 1.2e-07 31.8 0.2 0.0017 18.3 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFX01944.1 - 2.1e-07 30.6 0.9 0.0056 16.4 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Chromo PF00385.24 EFX01944.1 - 1.4e-06 28.1 1.3 2.9e-06 27.1 1.3 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_15 PF13175.6 EFX01944.1 - 0.00012 21.9 0.3 0.17 11.6 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFX01944.1 - 0.00052 20.3 0.1 0.52 10.6 0.0 3.4 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EFX01944.1 - 0.00067 19.9 0.0 0.032 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EFX01944.1 - 0.00068 19.7 0.0 0.43 10.6 0.0 3.3 3 0 0 3 3 3 1 Dynamin family DUF87 PF01935.17 EFX01944.1 - 0.0014 18.8 0.5 0.41 10.7 0.0 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_18 PF13238.6 EFX01944.1 - 0.0014 19.2 0.2 0.22 12.1 0.0 3.1 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 EFX01944.1 - 0.0023 17.8 0.2 1.4 8.8 0.0 2.8 2 0 0 2 2 2 1 NACHT domain PduV-EutP PF10662.9 EFX01944.1 - 0.0032 17.2 0.1 0.75 9.5 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFX01944.1 - 0.0034 17.1 1.0 0.56 9.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EFX01944.1 - 0.0052 15.8 1.6 0.78 8.7 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SbcCD_C PF13558.6 EFX01944.1 - 0.0062 16.7 0.0 3.5 7.9 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 EFX01944.1 - 0.0069 16.8 0.1 5.4 7.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.6 EFX01944.1 - 0.0079 16.6 0.6 2.1 8.7 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 EFX01944.1 - 0.008 16.3 0.0 2.7 8.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFX01944.1 - 0.0084 16.5 0.0 5.4 7.5 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 EFX01944.1 - 0.011 14.4 0.0 4.2 5.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EFX01944.1 - 0.019 15.2 0.0 5.6 7.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EFX01944.1 - 0.019 15.0 0.0 7.1 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 EFX01944.1 - 0.023 14.0 0.3 13 4.9 0.0 3.1 3 0 0 3 3 3 0 Septin DUF3093 PF11292.8 EFX01944.1 - 0.024 14.9 1.1 0.062 13.6 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) NB-ARC PF00931.22 EFX01944.1 - 0.032 13.4 0.1 2.2 7.4 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 EFX01944.1 - 0.035 13.3 0.0 3.7 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Ploopntkinase3 PF18751.1 EFX01944.1 - 0.06 13.2 0.1 7.8 6.4 0.0 2.9 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 EFX01944.1 - 0.097 12.2 0.2 15 5.0 0.0 2.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AIG1 PF04548.16 EFX01944.1 - 0.15 11.4 0.6 2.9 7.2 0.0 2.9 3 0 0 3 3 3 0 AIG1 family AAA_27 PF13514.6 EFX01944.1 - 0.16 11.5 2.7 6.9 6.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain FeoB_N PF02421.18 EFX01944.1 - 0.25 10.8 0.9 14 5.2 0.0 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B TsaE PF02367.17 EFX01944.1 - 0.32 11.0 1.1 34 4.4 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EFX01944.1 - 0.68 9.8 2.5 20 5.1 0.3 3.0 4 0 0 4 4 2 0 NTPase AAA_30 PF13604.6 EFX01944.1 - 1.2 8.8 9.8 4.3 7.0 0.0 3.7 4 0 0 4 4 4 0 AAA domain TRAM_LAG1_CLN8 PF03798.16 EFX01945.1 - 2.7e-46 157.8 18.4 4.4e-46 157.1 18.4 1.3 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EFX01945.1 - 1.5e-17 63.0 0.0 5.5e-17 61.2 0.0 2.1 1 0 0 1 1 1 1 TRAM1-like protein TRAP_alpha PF03896.16 EFX01945.1 - 0.14 11.3 0.1 0.23 10.6 0.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2149 PF09919.9 EFX01945.1 - 0.14 12.4 0.0 18 5.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) SH3_1 PF00018.28 EFX01946.1 - 2.4e-09 36.6 0.0 4.9e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFX01946.1 - 1.1e-06 28.3 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFX01946.1 - 3.4e-06 26.6 0.0 6.9e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Sod_Cu PF00080.20 EFX01947.1 - 7.6e-47 159.1 4.2 8.8e-47 158.8 4.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) FAD_binding_2 PF00890.24 EFX01948.1 - 2.2e-47 162.1 0.9 3e-47 161.6 0.9 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX01948.1 - 1e-11 45.1 0.3 1.8e-11 44.2 0.3 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX01948.1 - 4.4e-07 30.0 0.8 1.3e-06 28.5 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFX01948.1 - 1.8e-05 24.3 0.1 2.5e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFX01948.1 - 0.00035 19.9 1.4 0.0017 17.7 0.7 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EFX01948.1 - 0.0012 18.1 0.3 0.068 12.4 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX01948.1 - 0.0058 15.4 6.7 0.0069 15.1 0.6 2.4 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EFX01948.1 - 0.01 15.2 1.0 0.016 14.5 1.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EFX01948.1 - 0.012 14.7 4.2 0.016 14.3 1.6 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EFX01948.1 - 0.029 13.6 0.3 0.048 12.9 0.3 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFX01948.1 - 0.04 13.2 0.5 0.069 12.4 0.5 1.3 1 0 0 1 1 1 0 FAD binding domain adh_short_C2 PF13561.6 EFX01949.1 - 3.5e-59 200.2 1.1 4e-59 200.0 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX01949.1 - 1.8e-41 141.7 0.2 2.2e-41 141.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX01949.1 - 1.1e-10 41.7 1.1 1.8e-10 41.0 1.1 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFX01949.1 - 0.00056 19.9 0.3 0.0012 18.8 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EFX01949.1 - 0.0083 16.8 0.0 0.016 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ChuX_HutX PF06228.13 EFX01949.1 - 0.021 14.6 0.1 1.5 8.6 0.0 2.3 1 1 1 2 2 2 0 Haem utilisation ChuX/HutX Methyltransf_12 PF08242.12 EFX01949.1 - 0.028 15.1 0.0 0.057 14.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 EFX01949.1 - 0.051 13.0 0.1 0.079 12.4 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EFX01949.1 - 0.058 12.7 1.0 0.18 11.1 0.1 2.2 3 1 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RecC_C PF17946.1 EFX01949.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 RecC C-terminal domain ICL PF00463.21 EFX01950.1 - 1.3e-190 634.4 0.1 1.6e-190 634.1 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family DUF2458 PF10454.9 EFX01950.1 - 0.17 11.5 0.1 0.36 10.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Fungal_trans PF04082.18 EFX01951.1 - 1.8e-15 56.7 0.4 4e-15 55.6 0.4 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain NB-ARC PF00931.22 EFX01952.1 - 3.1e-08 33.1 0.0 5.6e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 EFX01952.1 - 4.3e-08 33.3 1.8 0.0011 19.2 0.7 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat AAA_22 PF13401.6 EFX01952.1 - 0.00035 20.8 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain TPR_10 PF13374.6 EFX01952.1 - 0.0039 17.0 1.7 17 5.4 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFX01952.1 - 0.0078 16.2 2.3 3.1 8.2 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-C2H2_jaz PF12171.8 EFX01952.1 - 0.065 13.5 0.3 0.065 13.5 0.3 3.7 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding AAA_16 PF13191.6 EFX01952.1 - 0.07 13.5 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EFX01952.1 - 0.13 12.1 0.0 0.41 10.5 0.0 1.9 1 0 0 1 1 1 0 NACHT domain zf-C2H2 PF00096.26 EFX01952.1 - 1.8 9.2 7.2 1.1 9.9 0.1 4.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type TPR_8 PF13181.6 EFX01952.1 - 3.1 8.3 4.8 5.4 7.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C2H2_2 PF12756.7 EFX01952.1 - 4.5 7.7 7.2 1 9.7 1.1 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) RPEL PF02755.15 EFX01953.1 - 5.8e-10 38.5 5.8 7.5e-08 31.8 0.0 2.7 3 0 0 3 3 3 2 RPEL repeat ChAPs PF09295.10 EFX01953.1 - 0.12 11.4 0.4 0.17 10.8 0.4 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Rad21_Rec8_N PF04825.13 EFX01954.1 - 4.5e-26 91.2 0.0 8.2e-26 90.3 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 EFX01954.1 - 0.049 13.5 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Segregation and condensation protein ScpA NST1 PF13945.6 EFX01955.1 - 0.52 10.4 0.0 0.52 10.4 0.0 3.6 4 1 0 4 4 4 0 Salt tolerance down-regulator MMR_HSR1 PF01926.23 EFX01956.1 - 3.7e-12 46.3 0.0 6.9e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX01956.1 - 0.001 18.6 0.0 0.002 17.7 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_33 PF13671.6 EFX01956.1 - 0.003 17.7 0.3 3.2 7.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EFX01956.1 - 0.0077 16.5 0.2 0.85 9.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EFX01956.1 - 0.0094 16.0 0.0 0.64 10.1 0.0 2.4 1 1 0 2 2 2 1 Dynamin family ClpS PF02617.17 EFX01956.1 - 0.012 15.3 0.1 0.032 14.0 0.1 1.6 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS RsgA_GTPase PF03193.16 EFX01956.1 - 0.016 15.1 0.0 0.095 12.6 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase Arf PF00025.21 EFX01956.1 - 0.026 14.0 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFX01956.1 - 0.071 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain eIF-5a PF01287.20 EFX01958.1 - 9.6e-07 28.8 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Cyclin_N2 PF16500.5 EFX01958.1 - 0.042 14.6 1.3 0.074 13.8 0.1 2.0 2 0 0 2 2 2 0 N-terminal region of cyclin_N p450 PF00067.22 EFX01959.1 - 1.2e-55 189.1 0.0 1.4e-55 188.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Carboxyl_trans PF01039.22 EFX01960.1 - 8.8e-133 443.5 0.0 1.2e-132 443.1 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain RTA1 PF04479.13 EFX01962.1 - 6.7e-70 234.9 10.1 9.3e-70 234.4 10.1 1.2 1 0 0 1 1 1 1 RTA1 like protein Syntaxin PF00804.25 EFX01963.1 - 3.7e-19 69.2 16.0 3.7e-19 69.2 16.0 2.1 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 EFX01963.1 - 1.5e-09 37.7 0.1 1.5e-09 37.7 0.1 3.0 3 0 0 3 3 3 1 SNARE domain Ferritin PF00210.24 EFX01963.1 - 0.043 13.7 1.8 0.26 11.2 0.0 2.2 2 0 0 2 2 2 0 Ferritin-like domain Mod_r PF07200.13 EFX01963.1 - 0.23 11.5 18.7 1.9 8.6 8.2 2.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Gp-FAR-1 PF05823.12 EFX01963.1 - 0.52 10.7 10.0 0.1 13.0 1.5 2.3 1 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) FAM76 PF16046.5 EFX01963.1 - 0.71 9.2 14.8 1.7 7.9 9.9 2.1 1 1 1 2 2 2 0 FAM76 protein CENP-F_leu_zip PF10473.9 EFX01963.1 - 1.8 8.6 13.1 0.16 12.0 3.2 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 EFX01963.1 - 2 8.5 13.7 2.6 8.1 1.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF5593 PF18007.1 EFX01963.1 - 2.5 8.9 5.1 18 6.1 0.7 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5593) DUF16 PF01519.16 EFX01963.1 - 4.7 7.7 18.6 5.4 7.6 6.7 2.5 1 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4094 PF13334.6 EFX01963.1 - 5 7.6 7.4 5.6 7.4 0.1 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4094) Rogdi_lz PF10259.9 EFX01965.1 - 4.1e-89 298.6 0.0 4.7e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Syntaxin-6_N PF09177.11 EFX01965.1 - 0.041 14.4 0.2 0.089 13.3 0.2 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal SEN1_N PF12726.7 EFX01966.1 - 8e-228 758.4 0.0 1e-227 758.1 0.0 1.1 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EFX01966.1 - 2e-70 237.5 0.4 2e-70 237.5 0.4 2.2 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EFX01966.1 - 6.9e-45 153.1 0.0 2.9e-43 147.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX01966.1 - 1.2e-08 35.5 0.0 4.4e-08 33.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX01966.1 - 3.8e-07 30.0 5.7 0.00034 20.4 0.7 3.0 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EFX01966.1 - 3.8e-06 26.8 0.4 0.063 13.0 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 EFX01966.1 - 8.4e-05 22.2 1.6 0.015 14.8 0.0 3.0 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Hemerythrin PF01814.23 EFX01966.1 - 0.024 15.3 0.8 0.1 13.2 0.8 2.1 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain AAA_29 PF13555.6 EFX01966.1 - 0.1 12.3 0.6 0.32 10.8 0.6 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-PHD-like PF15446.6 EFX01966.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain AAA PF00004.29 EFX01966.1 - 0.19 12.2 1.3 0.39 11.1 0.2 2.2 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX01966.1 - 5.5 7.3 5.4 1.3 9.3 0.1 2.7 4 0 0 4 4 3 0 AAA domain PI-PLC-X PF00388.19 EFX01967.1 - 1.6e-53 180.2 0.0 4.8e-53 178.7 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFX01967.1 - 6.4e-38 129.6 0.0 1.1e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain Acyl-CoA_dh_1 PF00441.24 EFX01968.1 - 4.3e-41 140.6 1.3 1.5e-40 138.9 1.3 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ADH_N PF08240.12 EFX01968.1 - 2.3e-28 98.2 7.9 2.3e-28 98.2 7.9 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Acyl-CoA_dh_N PF02771.16 EFX01968.1 - 1.5e-27 96.4 0.2 3.6e-27 95.3 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFX01968.1 - 1e-24 86.6 0.0 2.6e-24 85.2 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain ADH_zinc_N PF00107.26 EFX01968.1 - 6.3e-20 71.5 0.2 1.5e-19 70.3 0.2 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Acyl-CoA_dh_2 PF08028.11 EFX01968.1 - 2.9e-15 56.7 3.5 3.5e-15 56.4 0.3 2.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Glu_dehyd_C PF16912.5 EFX01968.1 - 1.4e-06 28.0 3.3 5.5e-05 22.7 1.9 3.1 2 1 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFX01968.1 - 6e-05 24.1 0.0 0.00023 22.2 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX01968.1 - 0.0016 17.8 0.5 0.0034 16.7 0.5 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HpaB_N PF11794.8 EFX01968.1 - 0.0022 17.7 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Asp PF00026.23 EFX01969.1 - 2.6e-73 247.2 7.6 3.1e-73 247.0 7.6 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX01969.1 - 9.1e-11 42.3 1.4 1.6e-06 28.5 0.1 2.9 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX01969.1 - 0.0075 16.9 1.3 1.2 9.9 0.5 3.2 2 1 0 2 2 2 1 Aspartyl protease Ctr PF04145.15 EFX01970.1 - 7e-37 127.3 2.3 1.2e-36 126.6 2.3 1.4 1 0 0 1 1 1 1 Ctr copper transporter family Abhydrolase_1 PF00561.20 EFX01970.1 - 5.3e-10 39.4 0.1 1e-09 38.4 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX01970.1 - 3.2e-09 37.7 0.3 5.7e-09 36.9 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX01970.1 - 7.2e-09 35.3 0.0 1.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Septin PF00735.18 EFX01971.1 - 1.1e-107 359.5 0.0 2.3e-107 358.5 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EFX01971.1 - 2.2e-05 24.5 0.0 5e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX01971.1 - 0.027 14.0 0.1 0.16 11.5 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFX01971.1 - 0.034 14.1 0.6 0.034 14.1 0.6 2.2 2 1 0 2 2 2 0 RsgA GTPase IIGP PF05049.13 EFX01971.1 - 0.066 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_23 PF13476.6 EFX01971.1 - 0.066 13.7 3.7 13 6.2 3.0 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFX01971.1 - 0.07 13.2 4.7 1.9 8.5 0.0 3.1 2 1 1 3 3 3 0 Dynamin family AAA_22 PF13401.6 EFX01971.1 - 0.12 12.7 1.7 0.22 11.8 0.1 2.1 2 1 0 2 2 2 0 AAA domain EB1 PF03271.17 EFX01971.1 - 0.22 11.8 2.0 5.5 7.3 1.1 2.7 2 0 0 2 2 2 0 EB1-like C-terminal motif FtsK_SpoIIIE PF01580.18 EFX01971.1 - 1.2 8.5 3.7 0.25 10.7 0.2 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family PCI PF01399.27 EFX01972.1 - 1.2e-22 80.3 0.1 4.3e-22 78.6 0.0 1.9 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EFX01972.1 - 1.1e-16 60.6 0.4 3e-16 59.2 0.4 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Prefoldin_2 PF01920.20 EFX01972.1 - 0.19 11.7 10.9 1.1 9.3 6.8 3.0 2 0 0 2 2 2 0 Prefoldin subunit PI3_PI4_kinase PF00454.27 EFX01973.1 - 4.9e-51 173.9 0.0 7.2e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 EFX01973.1 - 6.4e-27 93.4 0.2 2.2e-26 91.7 0.0 2.1 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 EFX01973.1 - 5.1e-18 65.4 0.1 1.1e-17 64.3 0.1 1.6 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 EFX01973.1 - 7e-14 51.3 1.7 9.7e-14 50.9 0.3 2.0 2 0 0 2 2 2 1 FATC domain HATPase_c PF02518.26 EFX01974.1 - 2.8e-21 76.1 0.1 5.4e-21 75.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFX01974.1 - 9.8e-20 70.8 0.0 3e-19 69.3 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.7 EFX01974.1 - 5.9e-09 36.1 0.0 0.0028 17.9 0.0 2.6 2 0 0 2 2 2 2 PAS domain HisKA PF00512.25 EFX01974.1 - 1.7e-08 34.4 0.1 4.2e-08 33.1 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EFX01974.1 - 1e-05 25.4 0.1 0.013 15.5 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 EFX01974.1 - 4.9e-05 23.6 0.0 3.9 7.8 0.0 3.6 3 1 0 3 3 3 2 PAS fold PAS_4 PF08448.10 EFX01974.1 - 8.5e-05 22.8 0.1 0.2 11.9 0.0 3.7 3 1 0 3 3 3 2 PAS fold PAS PF00989.25 EFX01974.1 - 0.013 15.5 0.0 4.1 7.5 0.0 3.3 2 1 0 2 2 2 0 PAS fold LigB PF02900.18 EFX01977.1 - 1e-30 106.7 0.5 1.9e-29 102.6 0.5 2.0 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase CDC27 PF09507.10 EFX01978.1 - 0.031 13.7 16.4 0.05 13.0 16.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 zf-CRD PF17979.1 EFX01978.1 - 0.14 12.2 1.2 0.3 11.2 1.2 1.5 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions zf-C2H2_4 PF13894.6 EFX01978.1 - 0.15 13.0 0.7 0.63 11.0 0.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Mitofilin PF09731.9 EFX01978.1 - 0.94 8.2 12.7 1.5 7.6 12.7 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PhoLip_ATPase_N PF16209.5 EFX01979.1 - 0.033 13.9 0.8 0.054 13.2 0.8 1.3 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal DASH_Spc19 PF08287.11 EFX01980.1 - 3.4e-48 163.5 1.4 3.4e-48 163.5 1.4 1.4 2 0 0 2 2 2 1 Spc19 DUF3287 PF11690.8 EFX01980.1 - 0.035 13.8 1.4 0.071 12.8 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Glyco_hydro_52 PF03512.13 EFX01980.1 - 0.042 12.8 0.2 0.048 12.6 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 DUF2570 PF10828.8 EFX01980.1 - 0.18 11.6 4.1 0.27 11.1 3.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) SlyX PF04102.12 EFX01980.1 - 0.19 12.4 8.5 0.5 11.0 0.5 3.3 3 1 0 3 3 3 0 SlyX Phage_TAC_11 PF11836.8 EFX01980.1 - 0.3 11.2 6.4 0.12 12.5 3.4 1.8 1 1 1 2 2 2 0 Phage tail tube protein, GTA-gp10 DASH_Spc34 PF08657.10 EFX01980.1 - 0.43 10.3 5.6 1.1 9.0 5.0 1.7 1 1 0 1 1 1 0 DASH complex subunit Spc34 DUF3138 PF11336.8 EFX01980.1 - 4.8 5.7 7.6 6.5 5.2 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) fn3_2 PF16893.5 EFX01981.1 - 6.7e-37 125.5 0.0 1.2e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EFX01981.1 - 1.2e-23 82.8 0.5 2e-23 82.0 0.5 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EFX01981.1 - 3.3e-08 33.4 0.0 5.8e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EFX01981.1 - 2.5e-05 24.6 0.0 4.1e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 EFX01981.1 - 0.0029 17.8 0.0 0.0072 16.5 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) CDC27 PF09507.10 EFX01981.1 - 0.0036 16.8 27.2 0.005 16.3 27.2 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 fn3 PF00041.21 EFX01981.1 - 0.012 15.9 0.0 0.034 14.5 0.0 1.8 1 1 0 1 1 1 0 Fibronectin type III domain BRCT_2 PF16589.5 EFX01981.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Cwf_Cwc_15 PF04889.12 EFX01981.1 - 0.095 12.4 10.8 0.15 11.8 10.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 EFX01981.1 - 0.26 10.9 6.3 0.53 9.9 6.3 1.5 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 EFX01981.1 - 0.27 10.5 12.2 0.39 10.0 12.2 1.2 1 0 0 1 1 1 0 NOA36 protein Utp14 PF04615.13 EFX01981.1 - 0.82 8.2 16.7 1.1 7.8 16.7 1.1 1 0 0 1 1 1 0 Utp14 protein Bul1_N PF04425.12 EFX01981.1 - 1.1 8.0 4.3 1.6 7.4 4.3 1.2 1 0 0 1 1 1 0 Bul1 N terminus PPP4R2 PF09184.11 EFX01981.1 - 1.2 8.7 11.8 1.7 8.2 11.8 1.2 1 0 0 1 1 1 0 PPP4R2 RXT2_N PF08595.11 EFX01981.1 - 1.3 9.0 7.3 2.1 8.4 7.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP1_TM PF14812.6 EFX01981.1 - 2 8.8 10.0 4.5 7.7 10.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 EFX01981.1 - 2.4 6.2 11.5 3.2 5.7 11.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi LAL_C2 PF18603.1 EFX01981.1 - 2.8 8.2 6.9 4.6 7.5 3.2 2.5 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 Nucleo_P87 PF07267.11 EFX01981.1 - 5.4 5.8 18.7 7.4 5.3 18.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SOG2 PF10428.9 EFX01981.1 - 7.9 5.6 15.4 12 5.0 15.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CDC45 PF02724.14 EFX01981.1 - 9.5 4.4 10.3 15 3.7 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1275 PF06912.11 EFX01982.1 - 5.2e-45 153.7 14.8 6.1e-45 153.5 14.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Prenyltrans PF00432.21 EFX01982.1 - 0.0036 17.0 0.6 0.12 12.2 0.1 2.6 2 0 0 2 2 2 1 Prenyltransferase and squalene oxidase repeat Mid2 PF04478.12 EFX01983.1 - 1.2e-08 35.0 1.2 1.2e-08 35.0 1.2 2.5 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor MAP17 PF15807.5 EFX01983.1 - 0.13 12.5 0.0 0.13 12.5 0.0 2.7 3 1 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Utp14 PF04615.13 EFX01983.1 - 2.4 6.6 7.9 2.8 6.4 7.9 1.2 1 0 0 1 1 1 0 Utp14 protein SWI-SNF_Ssr4 PF08549.10 EFX01983.1 - 5.9 5.4 29.3 8.9 4.8 29.3 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) IMS PF00817.20 EFX01985.1 - 4.6e-41 140.3 0.0 8.5e-41 139.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EFX01985.1 - 4.3e-15 56.4 1.6 5.3e-15 56.2 0.3 1.8 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain Peptidase_M61 PF05299.12 EFX01986.1 - 0.13 12.7 0.1 0.13 12.7 0.1 3.2 3 1 0 3 3 3 0 M61 glycyl aminopeptidase DUF3684 PF12449.8 EFX01986.1 - 0.24 9.2 13.6 0.84 7.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3684) Plasmodium_HRP PF05403.11 EFX01986.1 - 8.2 6.2 17.4 0.22 11.3 10.7 1.7 2 0 0 2 2 2 0 Plasmodium histidine-rich protein (HRPII/III) DFP PF04127.15 EFX01987.1 - 4.5e-13 49.5 0.0 0.0011 18.9 0.0 3.1 3 0 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein WH1 PF00568.23 EFX01988.1 - 2.4e-28 98.3 0.2 2.4e-28 98.3 0.2 1.4 2 0 0 2 2 2 1 WH1 domain CAP_N PF01213.19 EFX01988.1 - 0.00011 21.8 7.4 0.00011 21.8 7.4 11.6 2 1 8 10 10 10 1 Adenylate cyclase associated (CAP) N terminal WH2 PF02205.20 EFX01988.1 - 0.033 14.0 0.3 0.089 12.7 0.3 1.8 1 0 0 1 1 1 0 WH2 motif DCP1 PF06058.13 EFX01988.1 - 0.23 11.4 0.1 0.32 10.9 0.1 1.2 1 0 0 1 1 1 0 Dcp1-like decapping family NIPSNAP PF07978.13 EFX01989.1 - 4.6e-40 136.0 0.2 4.3e-30 104.0 0.2 2.4 2 0 0 2 2 2 2 NIPSNAP CNH PF00780.22 EFX01990.1 - 9e-61 205.9 0.0 1.5e-60 205.2 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EFX01990.1 - 3.7e-32 112.0 0.4 3.7e-32 112.0 0.4 1.8 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 EFX01990.1 - 1.9e-11 44.2 0.0 1.3e-10 41.5 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 EFX01990.1 - 0.00049 19.9 0.2 0.073 12.9 0.0 2.9 3 0 0 3 3 3 1 PH domain PH PF00169.29 EFX01990.1 - 0.0006 20.3 0.0 0.0052 17.3 0.0 2.5 2 0 0 2 2 2 1 PH domain ALO PF04030.14 EFX01991.1 - 5.9e-83 278.7 0.0 7.4e-78 262.0 0.0 2.1 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EFX01991.1 - 2.9e-27 95.1 0.7 6.2e-27 94.0 0.7 1.6 1 1 0 1 1 1 1 FAD binding domain NFACT-C PF11923.8 EFX01993.1 - 5.3e-36 122.8 1.3 1.1e-35 121.7 0.0 2.3 2 0 0 2 2 2 1 NFACT protein C-terminal domain FbpA PF05833.11 EFX01993.1 - 7.6e-24 84.3 0.0 1.1e-21 77.1 0.0 2.7 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EFX01993.1 - 4.1e-21 75.7 0.0 1.6e-20 73.8 0.0 2.1 2 0 0 2 2 2 1 NFACT protein RNA binding domain Myosin-VI_CBD PF16521.5 EFX01993.1 - 0.038 14.0 1.0 0.088 12.8 0.1 2.0 2 0 0 2 2 2 0 Myosin VI cargo binding domain DUF1115 PF06544.12 EFX01993.1 - 1.7 8.7 4.1 5.9 7.0 4.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) DLIC PF05783.11 EFX01994.1 - 2.9e-31 108.8 0.1 8.5e-28 97.4 0.0 2.4 2 1 0 2 2 2 2 Dynein light intermediate chain (DLIC) Methyltrn_RNA_3 PF02598.17 EFX01995.1 - 7.8e-97 324.2 0.0 9e-97 324.0 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase Ribosomal_S16 PF00886.19 EFX01996.1 - 2.4e-23 82.0 0.1 4.2e-23 81.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S16 DUF4191 PF13829.6 EFX01996.1 - 0.013 14.9 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Pet191_N PF10203.9 EFX01997.1 - 5.2e-27 93.9 4.5 6.8e-27 93.6 4.5 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COBRA PF04833.15 EFX01997.1 - 0.19 11.6 0.9 0.36 10.7 0.7 1.5 1 1 1 2 2 2 0 COBRA-like protein Spc7 PF08317.11 EFX01998.1 - 0.00022 20.2 124.5 0.0092 14.9 5.5 6.4 1 1 5 6 6 6 4 Spc7 kinetochore protein Csm1_N PF18504.1 EFX01998.1 - 0.003 17.9 0.6 0.003 17.9 0.6 12.2 7 3 6 14 14 14 1 Csm1 N-terminal domain ZapB PF06005.12 EFX01998.1 - 0.0072 16.7 1.3 0.0072 16.7 1.3 13.3 3 2 7 10 10 10 4 Cell division protein ZapB ATG16 PF08614.11 EFX01998.1 - 0.064 13.5 135.9 0.044 14.0 23.3 7.2 1 1 3 5 5 5 0 Autophagy protein 16 (ATG16) HALZ PF02183.18 EFX01998.1 - 0.28 11.5 0.0 0.28 11.5 0.0 11.8 10 5 1 11 11 11 0 Homeobox associated leucine zipper Shugoshin_N PF07558.11 EFX01998.1 - 3.7 7.5 33.3 0.17 11.8 0.7 7.5 7 1 0 8 8 8 0 Shugoshin N-terminal coiled-coil region APG6_N PF17675.1 EFX01998.1 - 4.3 7.9 152.0 0.31 11.6 12.9 9.5 1 1 8 9 9 9 0 Apg6 coiled-coil region RasGEF_N_2 PF14663.6 EFX01998.1 - 4.4 7.7 14.5 0.27 11.6 4.0 4.3 4 2 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF5082 PF16888.5 EFX01998.1 - 5.6 7.3 86.9 0.11 12.8 2.5 9.8 2 2 4 10 10 10 0 Domain of unknown function (DUF5082) YIF1 PF03878.15 EFX01999.1 - 5.5e-98 327.2 0.9 6.6e-98 327.0 0.9 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 EFX01999.1 - 0.0079 15.9 4.4 0.016 14.9 4.4 1.5 1 0 0 1 1 1 1 Yip1 domain PBP1_TM PF14812.6 EFX02000.1 - 0.11 12.9 11.7 2 8.8 6.3 4.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3040 PF11239.8 EFX02000.1 - 0.2 11.9 1.3 1.4 9.2 1.3 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) PAM2 PF07145.15 EFX02000.1 - 0.51 10.1 5.0 7.9 6.4 0.3 3.5 3 0 0 3 3 3 0 Ataxin-2 C-terminal region CFEM PF05730.11 EFX02001.1 - 2e-06 27.8 2.3 2e-06 27.8 2.3 3.7 3 0 0 3 3 3 1 CFEM domain YjeF_N PF03853.15 EFX02002.1 - 1.6e-23 83.4 0.0 3e-23 82.6 0.0 1.4 1 1 1 2 2 2 1 YjeF-related protein N-terminus RNase_H2_suC PF08615.11 EFX02002.1 - 0.06 13.5 0.0 0.062 13.5 0.0 1.1 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) HMGL-like PF00682.19 EFX02003.1 - 5.4e-76 255.6 0.2 7.2e-76 255.2 0.2 1.2 1 0 0 1 1 1 1 HMGL-like SRP-alpha_N PF04086.13 EFX02004.1 - 2.7e-73 247.4 6.5 9.2e-73 245.7 6.5 1.8 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EFX02004.1 - 2e-51 174.5 1.0 3.5e-51 173.6 0.0 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EFX02004.1 - 3.3e-08 33.6 0.1 9.6e-08 32.1 0.1 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EFX02004.1 - 1.6e-06 27.3 0.0 3.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EFX02004.1 - 0.00039 20.2 0.0 0.0012 18.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFX02004.1 - 0.0031 17.6 0.1 1.5 8.8 0.0 2.7 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 EFX02004.1 - 0.0084 16.5 1.1 0.068 13.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EFX02004.1 - 0.02 15.3 0.0 0.085 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 EFX02004.1 - 0.028 14.5 0.1 0.1 12.7 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 EFX02004.1 - 0.077 13.5 0.0 0.22 12.0 0.0 1.8 1 0 0 1 1 1 0 ABC transporter SUR7 PF06687.12 EFX02005.1 - 6.3e-37 127.3 10.8 9.7e-37 126.7 10.8 1.3 1 0 0 1 1 1 1 SUR7/PalI family Amastin PF07344.11 EFX02005.1 - 0.48 10.2 12.9 1.4 8.8 12.9 1.8 1 0 0 1 1 1 0 Amastin surface glycoprotein Cadherin_C_2 PF16492.5 EFX02005.1 - 0.66 10.8 2.9 27 5.6 0.0 2.7 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal CAP PF00188.26 EFX02006.1 - 5.2e-21 75.8 2.9 5.2e-21 75.8 2.9 1.8 2 0 0 2 2 2 1 Cysteine-rich secretory protein family DUF4680 PF15730.5 EFX02006.1 - 0.1 12.9 5.7 0.27 11.6 5.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) SAICAR_synt PF01259.18 EFX02007.1 - 3.7e-99 331.4 0.0 4.3e-99 331.2 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase DUF4006 PF13179.6 EFX02008.1 - 4.3 7.3 13.4 3.8 7.5 2.1 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF4006) MFS_1 PF07690.16 EFX02009.1 - 4.4e-25 88.3 33.5 4.4e-25 88.3 33.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 EFX02010.1 - 2.7e-34 118.4 1.4 3e-34 118.2 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02010.1 - 4.8e-24 85.2 0.1 7.6e-24 84.6 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02010.1 - 1.6e-06 28.2 1.0 9.4e-06 25.6 1.0 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX02010.1 - 0.0002 20.9 0.1 0.00058 19.4 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFX02010.1 - 0.1 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Nup54 PF13874.6 EFX02011.1 - 2e-41 141.4 1.3 2e-41 141.4 1.3 2.0 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_57_C PF18570.1 EFX02011.1 - 7.8e-16 57.4 8.8 1.4e-15 56.5 8.8 1.5 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain Nucleoporin_FG PF13634.6 EFX02011.1 - 3.7e-10 40.5 21.7 9.2e-10 39.2 21.7 1.6 1 1 0 1 1 1 1 Nucleoporin FG repeat region Adhesin_P1_N PF18652.1 EFX02011.1 - 0.0095 15.9 0.8 0.0095 15.9 0.8 2.1 2 0 0 2 2 2 1 Adhesin P1 N-terminal domain Pyr_excise PF03013.14 EFX02011.1 - 0.041 13.9 0.6 0.13 12.2 0.1 1.9 2 0 0 2 2 2 0 Pyrimidine dimer DNA glycosylase YscO-like PF16789.5 EFX02011.1 - 0.076 13.1 9.1 0.12 12.4 9.1 1.3 1 0 0 1 1 1 0 YscO-like protein DUF745 PF05335.13 EFX02011.1 - 0.12 12.1 4.3 0.11 12.2 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Rho_Binding PF08912.11 EFX02011.1 - 0.16 12.8 3.7 4.6 8.1 1.6 2.6 2 0 0 2 2 2 0 Rho Binding DivIVA PF05103.13 EFX02011.1 - 0.16 12.0 5.8 0.12 12.4 4.2 1.6 1 1 0 1 1 1 0 DivIVA protein ATP_Ca_trans_C PF12424.8 EFX02011.1 - 0.16 12.4 0.1 0.39 11.2 0.1 1.7 1 0 0 1 1 1 0 Plasma membrane calcium transporter ATPase C terminal LPP PF04728.13 EFX02011.1 - 0.2 12.1 1.4 1.4 9.4 0.1 2.8 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Tup_N PF08581.10 EFX02011.1 - 0.33 11.3 4.1 0.16 12.3 0.8 2.1 2 0 0 2 2 2 0 Tup N-terminal CEP63 PF17045.5 EFX02011.1 - 0.38 10.6 8.2 0.078 12.9 4.1 1.8 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa DUF4337 PF14235.6 EFX02011.1 - 0.92 9.6 4.1 0.24 11.5 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Muted PF14942.6 EFX02011.1 - 1.3 9.3 5.9 0.89 9.9 2.4 2.0 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ABC_tran_CTD PF16326.5 EFX02011.1 - 2 8.7 6.8 3.2 8.1 0.2 3.1 3 0 0 3 3 3 0 ABC transporter C-terminal domain bZIP_1 PF00170.21 EFX02011.1 - 2.7 8.2 5.7 34 4.6 0.3 3.3 3 1 0 3 3 3 0 bZIP transcription factor DUF2408 PF10303.9 EFX02011.1 - 2.9 8.4 5.9 4.2 7.9 0.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) GrpE PF01025.19 EFX02011.1 - 5.3 6.7 8.4 68 3.1 0.0 2.7 1 1 1 2 2 2 0 GrpE Aldo_ket_red PF00248.21 EFX02012.1 - 5.2e-54 183.4 0.0 5.8e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LSM PF01423.22 EFX02013.1 - 2.2e-19 68.9 0.0 2.7e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFX02013.1 - 0.021 14.9 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain NUDIX PF00293.28 EFX02014.1 - 1.9e-08 34.4 0.0 9.6e-06 25.7 0.0 2.1 2 0 0 2 2 2 2 NUDIX domain Mpv17_PMP22 PF04117.12 EFX02015.1 - 2.5e-11 43.6 1.0 2.5e-11 43.6 1.0 2.5 2 0 0 2 2 2 1 Mpv17 / PMP22 family HHH_2 PF12826.7 EFX02016.1 - 0.15 12.1 0.0 0.42 10.8 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Asp PF00026.23 EFX02017.1 - 5.1e-66 223.2 13.1 9.9e-66 222.3 13.1 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX02017.1 - 2.2e-12 47.6 7.0 5.5e-11 43.0 7.0 2.8 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX02017.1 - 1.8 9.3 9.6 11 6.7 0.1 4.1 3 2 1 4 4 4 0 Aspartyl protease Fungal_trans_2 PF11951.8 EFX02018.1 - 1.1e-14 54.0 0.0 2.7e-07 29.7 0.0 2.3 2 1 0 2 2 2 2 Fungal specific transcription factor domain Ribosomal_L24e PF01246.20 EFX02019.1 - 3.4e-28 97.6 0.2 3.4e-28 97.6 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e Myosin_head PF00063.21 EFX02020.1 - 1.9e-266 885.7 0.1 4.5e-266 884.4 0.0 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.19 EFX02020.1 - 4.3e-12 45.7 0.7 9.3e-12 44.6 0.7 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 EFX02020.1 - 2e-09 35.9 38.6 2e-09 35.9 38.6 7.7 2 2 6 8 8 8 6 Myosin tail Filament PF00038.21 EFX02020.1 - 0.00062 19.4 11.7 0.00062 19.4 11.7 10.8 2 2 5 7 7 7 1 Intermediate filament protein AAA_22 PF13401.6 EFX02020.1 - 0.1 12.9 0.0 0.1 12.9 0.0 5.3 6 0 0 6 6 6 0 AAA domain AAA_24 PF13479.6 EFX02020.1 - 0.17 11.6 2.6 2.7 7.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain DASH_Dad1 PF08649.10 EFX02020.1 - 4.3 7.6 7.0 18 5.6 0.1 4.6 4 0 0 4 4 4 0 DASH complex subunit Dad1 FAD_binding_4 PF01565.23 EFX02021.1 - 5.1e-05 23.0 0.0 0.00083 19.1 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Aldedh PF00171.22 EFX02023.1 - 1.6e-178 594.0 2.3 2.2e-178 593.5 2.3 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sulfate_transp PF00916.20 EFX02023.1 - 9.2e-76 255.0 10.1 1.7e-75 254.2 10.1 1.4 1 0 0 1 1 1 1 Sulfate permease family 5_nucleotid_C PF02872.18 EFX02023.1 - 3.2e-39 134.7 0.0 6e-39 133.8 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain STAS PF01740.21 EFX02023.1 - 9.5e-18 63.9 0.0 2e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 STAS domain Metallophos PF00149.28 EFX02023.1 - 1.4e-06 29.0 0.0 2.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STAS_2 PF13466.6 EFX02023.1 - 5.9e-05 23.3 0.0 0.0002 21.6 0.0 2.1 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFX02023.1 - 8.3 6.9 10.5 0.19 12.1 2.6 2.4 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily zf-3CxxC PF13695.6 EFX02024.1 - 1.4e-21 76.8 0.3 1.8e-21 76.5 0.3 1.1 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.4 EFX02024.1 - 0.028 15.2 2.2 8.9 7.1 0.2 2.9 3 0 0 3 3 3 0 Zinc-binding domain Ribosomal_S14 PF00253.21 EFX02025.1 - 2.6e-20 71.9 0.9 4.9e-20 71.0 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e OPT PF03169.15 EFX02026.1 - 1.6e-155 519.3 42.6 1.8e-155 519.1 42.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF1218 PF06749.12 EFX02026.1 - 7.4 7.2 9.5 1.3 9.6 1.9 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) Mpv17_PMP22 PF04117.12 EFX02027.1 - 8.3e-09 35.6 3.6 3.3e-08 33.7 2.2 2.1 2 0 0 2 2 2 1 Mpv17 / PMP22 family COesterase PF00135.28 EFX02028.1 - 2e-86 290.9 0.0 3.1e-86 290.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX02028.1 - 3.2e-05 23.9 0.3 0.00012 22.0 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX02028.1 - 0.0019 17.7 0.3 0.0032 17.0 0.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Ribosomal_L13 PF00572.18 EFX02029.1 - 6.5e-40 136.3 0.0 1.1e-39 135.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L13 LSM PF01423.22 EFX02030.1 - 1.7e-12 46.8 0.1 2.1e-12 46.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EFX02030.1 - 0.0099 15.5 0.1 0.015 14.9 0.1 1.4 1 0 0 1 1 1 1 Hfq protein HMA PF00403.26 EFX02031.1 - 2.7e-14 53.3 0.0 5.5e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EFX02031.1 - 3.6e-10 40.2 0.0 5.6e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TPR_11 PF13414.6 EFX02033.1 - 0.01 15.5 1.2 4.7 7.0 0.0 3.2 3 0 0 3 3 3 0 TPR repeat TPR_1 PF00515.28 EFX02033.1 - 0.027 14.3 1.0 7.1 6.6 0.0 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02033.1 - 1 9.6 6.7 16 5.9 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat EBP PF05241.12 EFX02034.1 - 5.8e-05 22.6 1.2 9.2e-05 22.0 1.2 1.3 1 0 0 1 1 1 1 Emopamil binding protein DUF5455 PF17537.2 EFX02034.1 - 0.047 14.1 2.0 0.08 13.4 2.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5455) 60KD_IMP PF02096.20 EFX02035.1 - 7.2e-13 48.8 9.7 1.2e-12 48.0 9.7 1.4 1 0 0 1 1 1 1 60Kd inner membrane protein MAGUK_N_PEST PF10608.9 EFX02035.1 - 0.17 12.4 1.9 0.42 11.1 1.9 1.6 1 0 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK DUF243 PF03103.17 EFX02036.1 - 0.024 14.9 1.8 0.046 14.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF243) MID_MedPIWI PF18296.1 EFX02036.1 - 0.15 11.8 2.0 0.17 11.7 2.0 1.0 1 0 0 1 1 1 0 MID domain of medPIWI zf-C2H2 PF00096.26 EFX02037.1 - 0.16 12.5 0.2 0.35 11.4 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 EFX02037.1 - 0.43 11.3 2.3 0.32 11.7 0.4 1.8 2 0 0 2 2 2 0 FOXP coiled-coil domain YabA PF06156.13 EFX02037.1 - 1.5 9.5 3.8 2.7 8.7 0.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Sugar_tr PF00083.24 EFX02038.1 - 1.4e-21 76.9 0.3 1.2e-18 67.2 0.1 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter Abi_2 PF07751.11 EFX02039.1 - 0.13 12.5 0.7 2 8.6 0.0 2.4 2 0 0 2 2 2 0 Abi-like protein CFEM PF05730.11 EFX02040.1 - 3.8e-09 36.5 11.5 5.5e-09 36.0 11.5 1.2 1 0 0 1 1 1 1 CFEM domain AAA PF00004.29 EFX02041.1 - 7.7e-09 36.1 0.5 2.7e-06 27.9 0.5 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX02041.1 - 0.0032 17.8 0.0 0.0092 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX02041.1 - 0.0065 16.9 0.0 0.023 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EFX02041.1 - 0.097 12.2 0.1 0.25 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFX02041.1 - 0.17 12.4 1.7 1.2 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Usp PF00582.26 EFX02042.1 - 9.5e-16 58.6 0.1 9.5e-16 58.6 0.1 2.2 2 0 0 2 2 2 1 Universal stress protein family PGA2 PF07543.12 EFX02042.1 - 1.2 9.1 6.2 2.2 8.2 3.6 2.5 3 0 0 3 3 3 0 Protein trafficking PGA2 CTP_synth_N PF06418.14 EFX02043.1 - 9.2e-121 402.2 0.1 1.2e-120 401.8 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EFX02043.1 - 5e-52 176.4 0.0 8.2e-52 175.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFX02043.1 - 1.3e-06 28.4 0.3 0.0047 16.7 0.0 2.6 3 0 0 3 3 3 2 Peptidase C26 ArsA_ATPase PF02374.15 EFX02043.1 - 0.22 10.7 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase Cid2 PF09774.9 EFX02045.1 - 5.1e-51 173.3 0.0 7.2e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 MFS_1 PF07690.16 EFX02046.1 - 8.7e-26 90.7 59.6 1.3e-19 70.3 31.0 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily Pox_Ag35 PF03286.14 EFX02048.1 - 0.021 14.6 3.8 0.023 14.5 3.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAA_hydrolase PF01557.18 EFX02049.1 - 8.5e-54 182.5 0.0 1.1e-53 182.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Arginase PF00491.21 EFX02050.1 - 2.4e-90 302.8 0.0 2.8e-90 302.6 0.0 1.0 1 0 0 1 1 1 1 Arginase family LIAS_N PF16881.5 EFX02051.1 - 5.6e-13 49.3 0.0 1e-12 48.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EFX02051.1 - 5.4e-12 46.4 0.0 8.9e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily ApbA_C PF08546.11 EFX02052.1 - 3.9e-33 114.3 0.0 1e-32 113.0 0.0 1.7 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFX02052.1 - 4.8e-31 107.5 0.0 6.4e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.22 EFX02052.1 - 0.0057 17.5 0.5 0.066 14.0 0.1 2.4 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold DAO PF01266.24 EFX02052.1 - 0.046 13.3 0.1 0.086 12.4 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFX02052.1 - 0.091 12.0 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain PglD_N PF17836.1 EFX02052.1 - 0.13 13.0 0.0 0.25 12.0 0.0 1.5 1 0 0 1 1 1 0 PglD N-terminal domain HI0933_like PF03486.14 EFX02052.1 - 0.13 10.9 0.1 0.2 10.4 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein ThiF PF00899.21 EFX02052.1 - 0.15 11.3 1.4 0.28 10.5 0.8 1.7 1 1 1 2 2 2 0 ThiF family FeS PF04060.13 EFX02052.1 - 0.39 10.4 2.5 0.96 9.2 2.5 1.6 1 0 0 1 1 1 0 Putative Fe-S cluster Phage_CII PF05269.11 EFX02053.1 - 0.02 15.1 0.6 67 3.8 0.0 4.2 1 1 1 3 3 3 0 Bacteriophage CII protein YCII PF03795.14 EFX02053.1 - 2.4 8.6 8.6 33 5.0 0.3 3.3 1 1 2 3 3 3 0 YCII-related domain Halo_GVPC PF05465.13 EFX02053.1 - 5.5 7.3 34.6 16 5.9 0.3 8.1 4 4 6 10 10 10 0 Halobacterial gas vesicle protein C (GVPC) repeat gp12-short_mid PF09089.10 EFX02053.1 - 9.6 6.5 10.3 25 5.1 0.5 3.5 1 1 2 3 3 3 0 Phage short tail fibre protein gp12, middle domain LIDHydrolase PF10230.9 EFX02054.1 - 4.1e-51 174.1 0.0 4.8e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EFX02054.1 - 0.0002 20.7 0.0 0.00087 18.6 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFX02054.1 - 0.034 13.8 0.2 0.14 11.7 0.1 2.0 2 1 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EFX02054.1 - 0.054 13.4 0.0 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold DOT1 PF08123.13 EFX02055.1 - 1.4e-73 246.9 0.0 1.9e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 EFX02055.1 - 0.039 13.2 0.1 0.067 12.5 0.1 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EFX02055.1 - 0.16 12.7 0.1 0.43 11.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain AhpC-TSA PF00578.21 EFX02056.1 - 4.1e-31 107.5 0.0 5.4e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFX02056.1 - 1e-13 51.2 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFX02056.1 - 1.2e-11 44.2 0.2 2.4e-11 43.3 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AAR2 PF05282.11 EFX02058.1 - 8.2e-38 130.7 0.0 3.7e-36 125.3 0.0 2.1 1 1 0 1 1 1 1 AAR2 protein Pex24p PF06398.11 EFX02059.1 - 4.5e-90 302.3 0.0 6.3e-90 301.8 0.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin FlgT_N PF16548.5 EFX02059.1 - 0.36 11.4 2.2 1 10.0 2.2 1.7 1 0 0 1 1 1 0 Flagellar assembly protein T, N-terminal domain Cupin_2 PF07883.11 EFX02060.1 - 4.9e-08 32.6 0.3 6.1e-07 29.1 0.3 2.3 1 1 0 1 1 1 1 Cupin domain Nuc_deoxyri_tr2 PF15891.5 EFX02061.1 - 3.2e-39 133.6 0.0 4.3e-39 133.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like SEP PF08059.13 EFX02062.1 - 2.3e-23 82.5 0.0 4e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 EFX02062.1 - 4.1e-12 45.7 0.4 6.6e-12 45.0 0.4 1.4 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFX02062.1 - 1.8e-06 28.0 0.0 3.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 UBX domain PGA2 PF07543.12 EFX02062.1 - 0.58 10.1 6.0 1 9.3 5.6 1.6 1 1 0 1 1 1 0 Protein trafficking PGA2 DUF2057 PF09829.9 EFX02062.1 - 0.74 9.9 8.3 2.9 8.0 0.4 2.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Fungal_trans PF04082.18 EFX02063.1 - 1.6e-15 56.9 0.2 7.4e-15 54.7 0.0 1.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02063.1 - 2.2e-08 34.1 10.7 4.1e-08 33.2 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HTH_51 PF18558.1 EFX02063.1 - 0.13 12.2 0.0 0.42 10.5 0.0 1.8 1 1 1 2 2 2 0 Helix-turn-helix domain ThrE PF06738.12 EFX02065.1 - 4.7e-64 216.0 3.9 4.7e-64 216.0 3.9 2.7 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EFX02065.1 - 2.3e-06 27.8 2.5 2.3e-06 27.8 2.5 3.8 4 0 0 4 4 4 2 Threonine/Serine exporter, ThrE DUF2651 PF10852.8 EFX02065.1 - 1.3 9.7 5.2 0.28 11.8 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2651) COX14 PF14880.6 EFX02066.1 - 7.7e-19 67.3 0.3 1.2e-18 66.7 0.3 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c assembly NmrA PF05368.13 EFX02067.1 - 5.9e-20 71.8 1.1 8.5e-20 71.3 1.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX02067.1 - 1.1e-16 61.2 0.1 2.4e-16 60.1 0.1 1.6 1 1 1 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EFX02067.1 - 0.003 17.1 0.1 0.0066 15.9 0.1 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 EFX02067.1 - 0.0051 16.3 0.1 0.012 15.1 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 EFX02067.1 - 0.014 15.2 1.0 0.087 12.6 0.0 2.3 2 1 1 3 3 3 0 DNA / pantothenate metabolism flavoprotein 3Beta_HSD PF01073.19 EFX02067.1 - 0.031 13.3 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.18 EFX02067.1 - 0.044 13.7 0.1 0.077 12.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFX02067.1 - 0.07 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 EFX02067.1 - 0.11 11.9 0.6 1.1 8.5 0.0 2.7 2 2 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DAGK_cat PF00781.24 EFX02068.1 - 1.1e-16 60.6 0.0 2.4e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Mucin PF01456.17 EFX02068.1 - 0.00011 22.2 13.9 0.00011 22.2 13.9 2.1 2 0 0 2 2 2 1 Mucin-like glycoprotein Dicty_REP PF05086.12 EFX02068.1 - 0.24 9.3 4.8 0.35 8.8 4.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4718 PF15842.5 EFX02068.1 - 0.28 11.0 1.8 0.57 9.9 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) NST1 PF13945.6 EFX02068.1 - 5.4 7.1 7.1 14 5.7 6.7 1.7 2 0 0 2 2 2 0 Salt tolerance down-regulator Sporozoite_P67 PF05642.11 EFX02068.1 - 8.3 4.4 8.8 0.12 10.4 1.2 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen EMC1_C PF07774.13 EFX02072.1 - 4.3e-64 216.1 0.0 6.1e-64 215.6 0.0 1.2 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EFX02072.1 - 2.1e-14 53.7 9.8 9.3e-14 51.6 4.4 2.8 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 EFX02072.1 - 0.0068 16.3 0.9 0.4 10.7 0.0 4.1 6 0 0 6 6 6 1 PQQ enzyme repeat Trans_reg_C PF00486.28 EFX02072.1 - 0.089 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal PQQ_3 PF13570.6 EFX02072.1 - 1 9.9 14.0 1.6 9.4 0.0 5.8 7 0 0 7 7 7 0 PQQ-like domain HET PF06985.11 EFX02073.1 - 1.5e-23 83.7 0.0 2.7e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FLILHELTA PF10306.9 EFX02074.1 - 1.9e-27 95.5 0.0 2.9e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 EFX02074.1 - 0.031 14.8 0.3 0.038 14.5 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1279) UDPG_MGDP_dh_N PF03721.14 EFX02075.1 - 7e-47 159.4 0.0 7.2e-30 103.9 0.0 2.3 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EFX02075.1 - 1.3e-32 111.9 0.0 2.3e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EFX02075.1 - 3.6e-21 75.6 0.0 9.8e-17 61.3 0.0 3.2 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 EFX02075.1 - 0.013 15.7 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EFX02075.1 - 0.1 12.8 0.0 0.32 11.3 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Choline_kinase PF01633.20 EFX02076.1 - 0.002 17.8 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase ATP_transf PF09830.9 EFX02077.1 - 9.1e-12 45.0 0.3 2.6e-11 43.5 0.0 1.9 2 0 0 2 2 2 1 ATP adenylyltransferase Choline_transpo PF04515.12 EFX02078.1 - 0.044 13.0 0.7 0.052 12.7 0.7 1.1 1 0 0 1 1 1 0 Plasma-membrane choline transporter SMP PF04927.12 EFX02078.1 - 0.33 11.4 2.8 4.1 8.0 0.1 2.4 2 0 0 2 2 2 0 Seed maturation protein SOTI PF17079.5 EFX02079.1 - 0.11 13.0 0.0 21 5.6 0.0 2.5 2 0 0 2 2 2 0 Male-specific protein scotti Zn_clus PF00172.18 EFX02080.1 - 0.0013 18.8 4.6 0.0023 18.0 4.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M20 PF01546.28 EFX02081.1 - 1e-31 110.3 0.1 1.4e-31 109.9 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX02081.1 - 4.7e-12 45.8 0.0 8.1e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Pkinase PF00069.25 EFX02082.1 - 2e-26 92.9 0.0 2.2e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02082.1 - 6.5e-14 51.8 0.0 9e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX02082.1 - 4.3e-09 35.6 0.0 6.2e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFX02082.1 - 0.00018 21.5 0.0 0.0016 18.4 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Mem_trans PF03547.18 EFX02083.1 - 2.7e-50 170.9 5.9 7.1e-50 169.5 5.9 1.6 1 1 0 1 1 1 1 Membrane transport protein DUF3506 PF12014.8 EFX02084.1 - 2.7e-42 144.1 0.0 5.8e-42 143.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) DUF1769 PF08588.10 EFX02084.1 - 7e-28 96.6 0.3 1.6e-27 95.5 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) F-box-like PF12937.7 EFX02084.1 - 3.9e-07 29.8 0.9 8.5e-07 28.8 0.9 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX02084.1 - 1.2e-06 28.2 1.6 2.6e-06 27.1 1.6 1.5 1 0 0 1 1 1 1 F-box domain 3Beta_HSD PF01073.19 EFX02085.1 - 0.00021 20.4 0.0 0.00043 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFX02085.1 - 0.00072 19.1 0.0 0.13 11.7 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFX02085.1 - 0.012 14.8 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein FAD_binding_3 PF01494.19 EFX02086.1 - 1.3e-16 60.9 8.0 1e-11 44.7 0.1 3.1 3 1 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 EFX02086.1 - 0.00039 19.7 0.2 0.0038 16.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX02086.1 - 0.00056 20.1 0.5 0.0016 18.7 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX02086.1 - 0.00057 19.6 9.8 0.0015 18.2 2.6 2.8 1 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFX02086.1 - 0.00087 19.8 0.6 0.002 18.6 0.6 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX02086.1 - 0.0018 17.7 0.0 0.17 11.1 0.0 2.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EFX02086.1 - 0.0026 17.8 2.3 0.009 16.0 0.2 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EFX02086.1 - 0.13 11.0 1.2 0.19 10.4 1.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Glyco_transf_90 PF05686.12 EFX02087.1 - 2.3e-14 53.2 0.5 3.6e-12 45.9 0.2 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 90 Peptidase_C1_2 PF03051.15 EFX02089.1 - 9.8e-140 466.2 0.0 1.3e-139 465.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EFX02089.1 - 4.5e-05 23.6 0.1 0.41 10.7 0.1 2.3 2 0 0 2 2 2 2 Papain family cysteine protease DUF3798 PF12683.7 EFX02089.1 - 0.25 10.7 0.0 0.5 9.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3798) UL11 PF11094.8 EFX02090.1 - 9.2 6.2 8.4 0.88 9.5 0.1 3.1 3 0 0 3 3 3 0 Membrane-associated tegument protein Lipoxygenase PF00305.19 EFX02092.1 - 2.4e-42 145.3 5.3 3.2e-41 141.5 5.3 2.0 1 1 0 1 1 1 1 Lipoxygenase ATP-synt_I PF03899.15 EFX02093.1 - 0.0075 16.6 0.6 0.0099 16.2 0.6 1.3 1 1 0 1 1 1 1 ATP synthase I chain EamA PF00892.20 EFX02093.1 - 0.045 13.9 8.5 0.051 13.7 8.5 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF202 PF02656.15 EFX02093.1 - 0.56 10.7 3.3 1 9.8 3.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF202) CTP_transf_1 PF01148.20 EFX02094.1 - 2.3e-78 263.6 26.5 2.9e-78 263.3 26.5 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family RhoGAP PF00620.27 EFX02095.1 - 4.2e-47 159.8 0.0 8.4e-47 158.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EFX02095.1 - 2.1e-12 47.1 0.1 6.5e-12 45.6 0.1 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain 4HBT_3 PF13622.6 EFX02096.1 - 7.7e-75 252.3 3.1 9.5e-75 252.0 3.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EFX02096.1 - 5e-20 71.7 0.0 1.6e-09 37.7 0.0 3.7 3 1 0 3 3 3 3 Acyl-CoA thioesterase Peptidase_S28 PF05577.12 EFX02097.1 - 3.2e-35 121.8 0.0 4e-34 118.2 0.0 2.2 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Pro-kuma_activ PF09286.11 EFX02098.1 - 4.7e-24 85.3 0.0 8.3e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFX02098.1 - 8.9e-06 25.2 0.1 1.4e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Subtilase family TRI12 PF06609.13 EFX02099.1 - 0.094 11.1 1.2 0.11 10.9 1.2 1.0 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Pro-kuma_activ PF09286.11 EFX02100.1 - 8.2e-47 159.1 0.0 1.8e-46 158.0 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFX02100.1 - 3.5e-05 23.2 0.1 0.00025 20.4 0.0 1.9 1 1 0 2 2 2 1 Subtilase family SSF PF00474.17 EFX02101.1 - 1.5e-15 57.0 31.4 1.5e-15 57.0 31.4 1.4 2 0 0 2 2 2 1 Sodium:solute symporter family NUDIX PF00293.28 EFX02101.1 - 3.6e-15 56.2 0.3 7.1e-15 55.2 0.3 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EFX02101.1 - 0.044 13.8 1.0 0.31 11.0 1.0 2.3 1 1 0 1 1 1 0 NUDIX domain AA_permease PF00324.21 EFX02102.1 - 1.6e-104 350.2 42.0 1.9e-104 349.9 42.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX02102.1 - 1.1e-26 93.7 43.7 1.3e-26 93.4 43.7 1.1 1 0 0 1 1 1 1 Amino acid permease WD40 PF00400.32 EFX02103.1 - 2.8e-22 78.6 19.2 1.4e-06 28.9 0.0 7.6 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02103.1 - 0.0024 18.1 2.6 1.3 9.4 0.1 4.4 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain POM121 PF15229.6 EFX02103.1 - 0.0035 17.0 0.1 1 8.9 0.0 2.1 2 0 0 2 2 2 2 POM121 family Coatomer_WDAD PF04053.14 EFX02103.1 - 0.27 10.2 0.3 3.1 6.7 0.2 2.0 2 0 0 2 2 2 0 Coatomer WD associated region ThuA PF06283.11 EFX02104.1 - 5.2e-49 167.3 4.1 7.2e-47 160.3 4.1 2.7 1 1 0 1 1 1 1 Trehalose utilisation ABC_tran PF00005.27 EFX02105.1 - 1.6e-45 155.0 0.0 8.9e-23 81.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EFX02105.1 - 1.2e-21 76.5 3.0 1.2e-21 76.5 3.0 3.1 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 EFX02105.1 - 7.6e-18 65.3 0.6 0.0004 20.3 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX02105.1 - 2.1e-12 46.9 0.1 2.5e-05 23.8 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFX02105.1 - 4.1e-08 34.0 4.4 0.043 14.3 0.0 3.8 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.6 EFX02105.1 - 5.6e-08 32.4 1.0 0.003 17.3 0.0 2.7 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EFX02105.1 - 6.2e-07 29.5 0.2 0.036 13.8 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 EFX02105.1 - 6.5e-07 29.9 0.0 0.0016 18.8 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFX02105.1 - 1.6e-06 28.4 0.0 0.026 14.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFX02105.1 - 3e-06 27.3 0.2 0.011 15.6 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase AAA_18 PF13238.6 EFX02105.1 - 9.9e-06 26.1 0.1 0.09 13.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EFX02105.1 - 1.4e-05 25.2 0.0 0.026 14.6 0.0 3.1 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EFX02105.1 - 0.00011 22.5 0.0 0.07 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFX02105.1 - 0.00017 21.9 0.7 1.1 9.7 0.0 3.2 3 0 0 3 3 3 2 RNA helicase AAA_33 PF13671.6 EFX02105.1 - 0.00034 20.8 1.1 0.26 11.4 0.1 3.0 4 0 0 4 4 2 1 AAA domain AAA PF00004.29 EFX02105.1 - 0.00035 21.0 0.0 0.98 9.8 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX02105.1 - 0.00052 20.0 0.1 1.3 9.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) NACHT PF05729.12 EFX02105.1 - 0.00058 19.8 0.1 0.92 9.4 0.0 2.5 2 0 0 2 2 2 2 NACHT domain Roc PF08477.13 EFX02105.1 - 0.0013 19.0 0.1 2.2 8.5 0.0 3.2 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 EFX02105.1 - 0.0016 18.1 0.0 0.46 10.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFX02105.1 - 0.0016 18.2 1.2 1.9 8.2 0.0 3.5 4 0 0 4 4 4 1 AAA domain NB-ARC PF00931.22 EFX02105.1 - 0.004 16.4 0.0 3.2 6.9 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain AAA_14 PF13173.6 EFX02105.1 - 0.0063 16.5 0.0 2.8 8.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFX02105.1 - 0.012 15.1 0.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2813 PF11398.8 EFX02105.1 - 0.024 13.9 0.1 8.4 5.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) AAA_25 PF13481.6 EFX02105.1 - 0.03 13.9 0.3 0.81 9.2 0.0 3.2 4 0 0 4 4 3 0 AAA domain AAA_30 PF13604.6 EFX02105.1 - 0.031 14.0 1.2 2.9 7.6 0.0 2.9 3 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EFX02105.1 - 0.06 13.3 0.0 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 EFX02105.1 - 0.064 13.0 0.3 3.3 7.4 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 EFX02105.1 - 0.064 12.4 0.8 3.8 6.6 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF815) DUF87 PF01935.17 EFX02105.1 - 0.067 13.3 0.4 16 5.5 0.0 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain AAA_17 PF13207.6 EFX02105.1 - 0.088 13.2 0.0 24 5.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFX02105.1 - 0.12 12.3 0.7 16 5.3 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea MukB PF04310.12 EFX02105.1 - 0.12 12.1 0.3 13 5.5 0.0 2.7 3 0 0 3 3 2 0 MukB N-terminal Rad17 PF03215.15 EFX02105.1 - 0.15 12.0 0.0 21 5.0 0.0 2.7 2 0 0 2 2 2 0 Rad17 P-loop domain DAP3 PF10236.9 EFX02105.1 - 0.28 10.3 1.8 16 4.6 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Synaptobrevin PF00957.21 EFX02106.1 - 1e-32 111.8 0.7 1.2e-32 111.5 0.7 1.1 1 0 0 1 1 1 1 Synaptobrevin HrpB4 PF09502.10 EFX02106.1 - 0.029 14.2 0.0 0.035 14.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB4) ODV-E18 PF10717.9 EFX02106.1 - 0.11 12.4 0.1 0.22 11.4 0.0 1.5 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 YqfQ PF14181.6 EFX02106.1 - 0.13 12.4 0.3 0.17 12.1 0.3 1.1 1 0 0 1 1 1 0 YqfQ-like protein Baculo_F PF12259.8 EFX02106.1 - 0.16 10.4 0.0 0.19 10.2 0.0 1.1 1 0 0 1 1 1 0 Baculovirus F protein AKNA PF12443.8 EFX02106.1 - 0.2 12.3 0.0 0.44 11.2 0.0 1.5 1 1 1 2 2 2 0 AT-hook-containing transcription factor UQ_con PF00179.26 EFX02107.1 - 6.4e-40 136.1 0.0 7.2e-40 135.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX02107.1 - 0.00012 21.8 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFX02107.1 - 0.0049 16.7 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EFX02107.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 RWD domain ERG4_ERG24 PF01222.17 EFX02108.1 - 9.2e-170 565.0 1.1 1.1e-169 564.8 1.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFX02108.1 - 0.0011 18.5 1.2 0.0032 17.0 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF2196 PF09962.9 EFX02109.1 - 8.4e-24 83.3 4.0 1.6e-23 82.4 4.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) zf-Di19 PF05605.12 EFX02109.1 - 0.14 12.5 0.3 0.21 11.9 0.3 1.2 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Peptidase_M61 PF05299.12 EFX02110.1 - 5.8e-32 110.6 0.0 2.4e-31 108.6 0.0 2.0 2 0 0 2 2 2 1 M61 glycyl aminopeptidase Peptidase_M61_N PF17899.1 EFX02110.1 - 7.4e-18 65.2 0.0 1.3e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M61 N-terminal domain PDZ_2 PF13180.6 EFX02110.1 - 0.0025 18.1 0.0 0.0055 17.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Peptidase_M9 PF01752.17 EFX02110.1 - 0.069 12.4 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 Collagenase Peptidase_M1 PF01433.20 EFX02110.1 - 0.23 11.0 0.0 0.48 10.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M1 domain Pal1 PF08316.11 EFX02111.1 - 1.5e-19 71.2 0.5 5.3e-19 69.4 0.1 2.0 2 0 0 2 2 2 1 Pal1 cell morphology protein Ras PF00071.22 EFX02112.1 - 4.8e-42 143.3 0.0 6e-42 143.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX02112.1 - 2.4e-12 47.1 0.0 4e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX02112.1 - 0.00087 18.8 0.0 0.0038 16.7 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Ank_4 PF13637.6 EFX02113.1 - 3.1e-14 53.1 1.1 2.4e-07 31.1 0.1 4.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX02113.1 - 6.5e-09 36.3 0.2 0.0054 17.3 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFX02113.1 - 3.4e-08 33.6 6.4 0.11 13.0 0.1 4.9 5 0 0 5 5 4 2 Ankyrin repeat Ank_3 PF13606.6 EFX02113.1 - 7.5e-08 32.1 3.6 0.071 13.7 0.0 4.8 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFX02113.1 - 7.1e-06 26.2 0.6 0.039 14.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.13 EFX02113.1 - 0.00021 21.1 0.3 0.0012 18.7 0.3 2.2 1 1 0 1 1 1 1 KilA-N domain Tmemb_cc2 PF10267.9 EFX02113.1 - 0.00054 19.2 1.0 0.0011 18.2 1.0 1.4 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Macoilin PF09726.9 EFX02113.1 - 0.011 14.4 1.0 0.017 13.7 1.0 1.3 1 0 0 1 1 1 0 Macoilin family Muted PF14942.6 EFX02113.1 - 0.33 11.3 2.6 0.73 10.2 2.6 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein OmpH PF03938.14 EFX02113.1 - 0.35 11.2 8.2 0.18 12.1 5.4 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Fez1 PF06818.15 EFX02113.1 - 0.9 10.0 7.2 1.7 9.0 7.2 1.4 1 0 0 1 1 1 0 Fez1 CREPT PF16566.5 EFX02113.1 - 0.92 9.7 6.0 0.21 11.8 2.3 1.7 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Exonuc_VII_L PF02601.15 EFX02113.1 - 1 8.9 8.5 2.1 7.8 8.5 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit T3SSipB PF16535.5 EFX02113.1 - 1.5 9.3 11.8 3.7 8.0 11.8 1.7 1 1 0 1 1 1 0 Type III cell invasion protein SipB Hrs_helical PF12210.8 EFX02113.1 - 2.4 8.7 11.5 0.091 13.3 3.6 2.5 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate GAS PF13851.6 EFX02113.1 - 3.4 6.9 8.3 0.95 8.8 4.5 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Methyltransf_23 PF13489.6 EFX02114.1 - 4e-10 39.8 0.0 3.9e-07 30.0 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02114.1 - 4e-08 33.8 0.0 2.2e-07 31.4 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02114.1 - 5.8e-06 26.9 0.1 0.00034 21.3 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX02114.1 - 9.1e-06 25.2 0.1 0.00044 19.7 0.0 2.2 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EFX02114.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.12 EFX02114.1 - 0.0074 17.0 0.0 0.031 15.0 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02114.1 - 0.013 15.3 0.0 0.17 11.7 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain MTS PF05175.14 EFX02114.1 - 0.14 11.7 0.0 0.84 9.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain NMO PF03060.15 EFX02116.1 - 9.1e-20 71.3 17.1 1.8e-12 47.3 10.6 3.1 2 1 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 EFX02116.1 - 4.3e-07 29.3 0.1 0.018 14.1 1.7 2.2 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EFX02116.1 - 0.002 17.4 3.6 0.44 9.6 1.2 2.1 1 1 1 2 2 2 2 Conserved region in glutamate synthase FMN_dh PF01070.18 EFX02116.1 - 0.012 14.6 5.1 0.02 14.0 5.1 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase GYF PF02213.16 EFX02117.1 - 4e-18 64.8 2.2 8.5e-18 63.8 0.3 2.4 2 0 0 2 2 2 1 GYF domain TPR_16 PF13432.6 EFX02117.1 - 1.4e-07 32.1 1.6 1.4e-07 32.1 1.6 4.1 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02117.1 - 9.7e-07 29.0 2.0 0.005 17.1 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX02117.1 - 2.5e-06 27.0 0.1 0.2 11.5 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02117.1 - 6.5e-06 25.9 5.3 0.071 13.3 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFX02117.1 - 0.0004 20.5 0.6 0.0014 18.8 0.6 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFX02117.1 - 0.00075 19.1 0.1 0.01 15.5 0.0 2.9 3 0 0 3 3 3 1 TPR repeat GYF_2 PF14237.6 EFX02117.1 - 0.013 15.3 0.1 0.037 13.8 0.1 1.9 1 0 0 1 1 1 0 GYF domain 2 TPR_19 PF14559.6 EFX02117.1 - 0.019 15.5 1.8 0.064 13.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02117.1 - 0.026 14.5 0.2 1.4 9.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.9 EFX02117.1 - 0.037 13.8 0.7 3.9 7.1 0.1 3.2 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_14 PF13428.6 EFX02117.1 - 0.043 14.6 0.1 0.043 14.6 0.1 5.8 7 1 1 8 8 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02117.1 - 0.13 12.5 0.0 1.1 9.7 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_23 PF13489.6 EFX02118.1 - 4.6e-21 75.3 0.0 6.9e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02118.1 - 2.5e-13 50.5 0.0 1.1e-12 48.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02118.1 - 3.9e-12 46.7 0.0 9.3e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02118.1 - 5e-09 36.8 0.0 3.7e-08 34.0 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02118.1 - 1.4e-08 34.7 0.0 5.2e-07 29.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX02118.1 - 8.7e-05 22.0 0.0 0.001 18.4 0.0 2.3 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EFX02118.1 - 0.00041 20.1 0.0 0.00066 19.4 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFX02118.1 - 0.00083 18.8 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFX02118.1 - 0.0025 17.4 0.0 0.0051 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX02118.1 - 0.0026 17.2 0.0 0.0072 15.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.19 EFX02118.1 - 0.0061 16.7 0.2 0.039 14.1 0.0 2.1 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EFX02118.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain DUF938 PF06080.12 EFX02118.1 - 0.074 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) DUF4124 PF13511.6 EFX02118.1 - 0.14 12.5 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) 2-Hacid_dh_C PF02826.19 EFX02120.1 - 2e-38 131.5 0.0 7.9e-38 129.6 0.0 1.9 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX02120.1 - 5.9e-19 68.1 0.0 7.5e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EFX02120.1 - 0.0035 17.8 0.1 0.012 16.1 0.0 1.9 2 0 0 2 2 2 1 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 EFX02120.1 - 0.0063 16.6 0.2 0.015 15.4 0.2 1.6 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EFX02120.1 - 0.011 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 EFX02120.1 - 0.015 15.9 0.0 0.041 14.5 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EFX02120.1 - 0.036 13.7 0.4 0.07 12.8 0.4 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EFX02120.1 - 0.043 13.9 0.1 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EFX02120.1 - 0.12 12.6 0.6 0.48 10.7 0.1 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Peptidase_M20 PF01546.28 EFX02121.1 - 2.2e-27 96.1 0.4 2.8e-27 95.8 0.4 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX02121.1 - 2.1e-06 27.6 0.2 4.7e-06 26.5 0.2 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFX02121.1 - 0.031 14.0 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Cu-oxidase_3 PF07732.15 EFX02122.1 - 1e-43 148.1 5.6 4.3e-42 142.9 1.9 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX02122.1 - 3.9e-42 143.2 3.6 3.9e-38 130.3 0.2 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX02122.1 - 1.9e-32 112.6 0.2 4.6e-32 111.3 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Ldh_1_N PF00056.23 EFX02123.1 - 4.6e-44 149.9 0.1 8.5e-44 149.1 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EFX02123.1 - 1.3e-42 145.5 0.0 2.6e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EFX02123.1 - 0.0012 18.0 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EFX02123.1 - 0.013 15.1 0.1 0.88 9.1 0.1 2.4 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Semialdhyde_dh PF01118.24 EFX02123.1 - 0.11 12.9 0.5 0.58 10.6 0.0 2.4 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain Amidohydro_2 PF04909.14 EFX02124.1 - 4e-42 145.0 0.3 4.9e-42 144.7 0.3 1.0 1 0 0 1 1 1 1 Amidohydrolase NDUF_B7 PF05676.13 EFX02125.1 - 6.2e-29 99.5 4.5 7.3e-29 99.3 4.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Xan_ur_permease PF00860.20 EFX02126.1 - 5.2e-24 84.7 29.1 5.3e-22 78.1 29.1 2.4 1 1 0 1 1 1 1 Permease family Sulfate_transp PF00916.20 EFX02126.1 - 0.00029 19.7 14.5 0.0033 16.2 14.5 2.3 1 1 0 1 1 1 1 Sulfate permease family RPN2_C PF18004.1 EFX02127.1 - 1.7e-52 177.5 0.9 1.7e-52 177.5 0.9 2.5 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EFX02127.1 - 1.5e-36 123.0 22.0 1.2e-06 28.7 0.0 8.5 8 0 0 8 8 8 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFX02127.1 - 3.2e-21 75.5 1.0 1.2e-13 51.2 0.0 6.6 6 1 1 7 7 7 2 HEAT repeats HEAT_EZ PF13513.6 EFX02127.1 - 2.3e-06 27.9 0.1 0.0088 16.5 0.0 5.3 3 1 1 4 4 4 2 HEAT-like repeat HEAT PF02985.22 EFX02127.1 - 1.2e-05 25.1 0.0 5.7 7.5 0.0 6.0 5 0 0 5 5 5 1 HEAT repeat DUF913 PF06025.12 EFX02127.1 - 0.56 9.1 3.5 5.8 5.8 1.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF3188 PF11384.8 EFX02127.1 - 1.3 8.8 3.0 1.1 9.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) Pkinase PF00069.25 EFX02128.1 - 4.2e-62 209.9 0.0 5.5e-62 209.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02128.1 - 3e-27 95.5 0.0 1.3e-17 64.0 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFX02128.1 - 0.0011 18.9 0.4 0.028 14.3 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFX02128.1 - 0.0031 16.5 0.0 0.0042 16.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFX02128.1 - 0.015 14.7 0.9 0.083 12.2 0.9 2.0 1 1 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 EFX02128.1 - 0.052 12.6 0.0 0.077 12.0 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 ACPS PF01648.20 EFX02129.1 - 3.5e-07 30.4 0.0 5.6e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily FHA PF00498.26 EFX02130.1 - 5.5e-15 55.5 0.0 1.2e-14 54.3 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EFX02130.1 - 3.6e-13 49.0 5.2 3.6e-13 49.0 5.2 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 EFX02130.1 - 1.4e-06 28.5 8.6 1.4e-06 28.5 8.6 1.7 2 0 0 2 2 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 EFX02130.1 - 0.00025 21.3 0.0 0.00046 20.4 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 EFX02130.1 - 0.0013 18.6 7.7 0.0023 17.8 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX02130.1 - 0.0028 17.6 5.7 0.0049 16.8 5.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain PHD PF00628.29 EFX02130.1 - 0.0038 17.1 4.7 0.0071 16.2 4.7 1.5 1 0 0 1 1 1 1 PHD-finger zf-C3HC4_3 PF13920.6 EFX02130.1 - 0.0095 15.8 4.5 0.017 15.0 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX02130.1 - 0.013 15.4 7.9 0.024 14.5 7.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFX02130.1 - 0.016 15.2 1.4 0.031 14.3 1.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFX02130.1 - 0.064 13.3 7.9 0.14 12.2 7.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFX02130.1 - 0.17 12.2 7.0 0.51 10.7 7.0 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFX02130.1 - 2.4 8.4 5.9 5.9 7.1 5.9 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING TPT PF03151.16 EFX02132.1 - 8.6e-37 127.1 12.1 1e-36 126.8 12.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EFX02132.1 - 8.8e-13 48.1 14.4 1.3e-12 47.6 14.4 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFX02132.1 - 4.1e-05 23.8 26.5 0.00046 20.4 6.9 2.5 2 1 0 2 2 2 2 EamA-like transporter family SR-25 PF10500.9 EFX02132.1 - 0.63 9.6 12.1 0.87 9.2 12.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Brix PF04427.18 EFX02133.1 - 5.5e-48 163.6 0.0 7.3e-48 163.2 0.0 1.2 1 0 0 1 1 1 1 Brix domain DA1-like PF12315.8 EFX02133.1 - 0.022 14.1 0.5 0.041 13.3 0.5 1.4 1 0 0 1 1 1 0 Protein DA1 MRPL52 PF18699.1 EFX02133.1 - 0.12 12.6 5.5 0.42 10.8 5.5 2.0 1 0 0 1 1 1 0 Mitoribosomal protein mL52 Rtf2 PF04641.12 EFX02133.1 - 7.5 5.8 11.1 0.33 10.3 5.4 1.5 2 0 0 2 2 2 0 Rtf2 RING-finger WD40 PF00400.32 EFX02134.1 - 2.2e-10 40.9 2.1 0.028 15.3 1.4 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Aldedh PF00171.22 EFX02135.1 - 1.5e-89 300.6 0.0 4.3e-49 167.3 0.2 2.1 1 1 1 2 2 2 2 Aldehyde dehydrogenase family MFS_1 PF07690.16 EFX02135.1 - 3.1e-33 115.2 31.3 3.1e-33 115.2 31.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02135.1 - 8e-06 25.0 25.3 7.2e-05 21.8 25.3 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter 4HBT_2 PF13279.6 EFX02136.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Thioesterase-like superfamily FAR1 PF03101.15 EFX02137.1 - 9.8e-06 26.2 0.2 1.4e-05 25.7 0.2 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain HSBP1 PF06825.12 EFX02137.1 - 0.00023 20.9 1.7 0.013 15.3 1.5 2.6 2 1 1 3 3 3 1 Heat shock factor binding protein 1 AFT PF08731.11 EFX02137.1 - 0.00063 20.1 0.1 0.00091 19.6 0.1 1.3 1 0 0 1 1 1 1 Transcription factor AFT Baculo_PEP_C PF04513.12 EFX02137.1 - 0.00071 19.6 0.0 0.002 18.2 0.0 1.8 2 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Sugarporin_N PF11471.8 EFX02137.1 - 0.0011 18.9 0.1 2.1 8.3 0.0 2.4 2 0 0 2 2 2 2 Maltoporin periplasmic N-terminal extension DUF1664 PF07889.12 EFX02137.1 - 0.018 15.1 0.0 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) XhlA PF10779.9 EFX02137.1 - 0.02 15.1 0.4 0.97 9.7 0.4 2.5 2 1 0 2 2 2 0 Haemolysin XhlA Sec10 PF07393.11 EFX02137.1 - 0.079 11.4 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 OmpH PF03938.14 EFX02137.1 - 0.095 13.0 0.2 14 6.0 0.1 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Apolipoprotein PF01442.18 EFX02137.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Chorismate_synt PF01264.21 EFX02137.1 - 0.16 10.6 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 Chorismate synthase Cob_adeno_trans PF01923.18 EFX02137.1 - 0.17 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Cyclin_C_2 PF16899.5 EFX02138.1 - 3.5e-30 104.5 0.1 8.2e-29 100.1 0.0 2.4 2 0 0 2 2 2 1 Cyclin C-terminal domain QLQ PF08880.11 EFX02138.1 - 0.13 12.0 1.7 3 7.7 0.0 3.0 3 0 0 3 3 3 0 QLQ MoaE PF02391.17 EFX02139.1 - 9.8e-39 132.1 0.0 1.2e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 MoaE protein DUF5130 PF17174.4 EFX02139.1 - 0.085 13.1 0.1 0.22 11.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5130) Dabb PF07876.12 EFX02140.1 - 1.2e-15 57.8 0.0 1.6e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain IFS PF16718.5 EFX02140.1 - 0.006 16.7 0.1 0.0074 16.4 0.1 1.1 1 0 0 1 1 1 1 Immunity factor for SPN Cyt-b5 PF00173.28 EFX02141.1 - 3.4e-16 59.2 0.0 4.7e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PurK_C PF17769.1 EFX02142.1 - 0.18 11.5 0.0 0.43 10.3 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylaminoimidazole carboxylase C-terminal domain DUF3636 PF12331.8 EFX02143.1 - 5.7e-43 146.3 0.0 1.3e-42 145.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) DUF484 PF04340.12 EFX02143.1 - 0.12 12.0 1.0 0.22 11.2 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF484 DUF4988 PF16378.5 EFX02143.1 - 0.22 11.1 0.1 0.43 10.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function Histone_HNS PF00816.21 EFX02143.1 - 1.2 10.0 4.1 2.7 8.9 4.1 1.6 1 0 0 1 1 1 0 H-NS histone family Aminotran_3 PF00202.21 EFX02144.1 - 7.8e-82 275.1 0.0 9.6e-82 274.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EFX02144.1 - 0.026 13.8 0.0 0.07 12.4 0.0 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase Polysacc_synt_4 PF04669.13 EFX02145.1 - 1.2e-23 83.7 0.9 4.7e-22 78.5 0.9 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Kelch_4 PF13418.6 EFX02146.1 - 6.1e-16 58.2 0.1 6.5e-05 22.9 0.0 4.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFX02146.1 - 2.7e-13 49.6 5.1 6e-06 26.1 0.0 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EFX02146.1 - 2.3e-12 46.8 4.9 5e-08 33.1 0.0 5.5 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFX02146.1 - 1.4e-10 40.6 0.1 0.035 13.7 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFX02146.1 - 8.1e-10 38.3 0.1 0.0036 17.2 0.0 4.0 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 EFX02146.1 - 9.8e-09 35.2 4.8 0.25 11.7 0.3 5.4 5 1 0 5 5 5 3 Kelch motif BTB PF00651.31 EFX02146.1 - 0.0033 17.6 0.0 0.11 12.8 0.0 2.5 2 0 0 2 2 2 1 BTB/POZ domain Hydrolase_4 PF12146.8 EFX02147.1 - 0.11 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DnaJ-X PF14308.6 EFX02149.1 - 5.6e-76 254.7 2.4 5.6e-76 254.7 2.4 2.0 3 0 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 EFX02149.1 - 1.7e-25 88.9 1.0 3.9e-25 87.8 1.0 1.7 1 0 0 1 1 1 1 DnaJ domain SLX9 PF15341.6 EFX02149.1 - 4.3 7.7 11.1 7.7 6.9 1.0 3.2 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 Inositol_P PF00459.25 EFX02152.1 - 2.1e-34 119.3 0.4 9.1e-34 117.2 0.4 2.0 1 1 0 1 1 1 1 Inositol monophosphatase family MFS_1 PF07690.16 EFX02153.1 - 5.3e-34 117.7 32.2 7.6e-34 117.2 32.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02153.1 - 2.3e-10 39.9 6.5 2.3e-10 39.9 6.5 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter NARP1 PF12569.8 EFX02154.1 - 2.1e-174 581.3 23.2 2.2e-174 581.2 12.7 2.5 3 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 EFX02154.1 - 4.9e-10 39.1 2.8 1.4 9.5 0.0 7.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX02154.1 - 3.6e-08 33.9 59.4 0.0042 17.7 0.3 9.9 9 1 2 11 11 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFX02154.1 - 1.2e-06 28.9 43.0 0.00076 19.9 0.3 9.0 10 1 0 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFX02154.1 - 3.4e-06 26.6 0.1 3.4e-06 26.6 0.1 4.7 5 0 0 5 5 5 1 TPR repeat TPR_2 PF07719.17 EFX02154.1 - 4e-06 26.5 34.8 0.00027 20.8 0.3 10.2 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX02154.1 - 3.7e-05 23.3 0.3 3.7e-05 23.3 0.3 7.4 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFX02154.1 - 0.00012 22.1 0.9 0.00012 22.1 0.9 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02154.1 - 0.00013 21.9 11.3 0.0017 18.4 0.1 5.8 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02154.1 - 0.00035 20.8 18.0 0.4 11.0 0.0 6.5 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX02154.1 - 0.0021 18.7 0.1 0.0021 18.7 0.1 12.0 9 3 6 15 15 12 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX02154.1 - 0.01 16.0 0.4 0.01 16.0 0.4 3.6 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TssO PF17561.2 EFX02154.1 - 0.055 13.6 3.2 0.14 12.2 3.2 1.6 1 0 0 1 1 1 0 Type VI secretion system, TssO Fis1_TPR_C PF14853.6 EFX02154.1 - 0.074 13.1 9.4 7.7 6.7 0.1 4.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EFX02154.1 - 0.18 11.7 13.6 6.9 6.7 0.0 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFX02154.1 - 0.63 10.8 15.2 0.59 10.9 0.4 6.5 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFX02154.1 - 2.9 8.7 20.3 7.7 7.4 0.1 8.2 7 1 1 8 8 7 0 Tetratricopeptide repeat E1-E2_ATPase PF00122.20 EFX02155.1 - 1.5e-16 60.4 0.0 3.3e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFX02155.1 - 1.1e-13 52.0 3.8 1.3e-07 32.1 3.7 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFX02155.1 - 0.00068 19.7 0.0 0.0076 16.3 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFX02155.1 - 0.0031 17.3 0.1 0.055 13.2 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase 4HBT PF03061.22 EFX02156.1 - 9.8e-09 35.5 0.0 2e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DAP_B PF07930.12 EFX02159.1 - 0.071 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 D-aminopeptidase, domain B LRR_8 PF13855.6 EFX02160.1 - 9.5e-08 31.7 4.7 2.6e-07 30.3 4.7 1.8 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 EFX02160.1 - 1.6e-06 28.3 7.5 1.9e-05 24.9 1.0 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFX02160.1 - 0.27 11.4 4.4 9.6 6.6 0.4 2.6 2 0 0 2 2 2 0 Leucine Rich repeat PRIMA1 PF16101.5 EFX02160.1 - 2.9 8.0 7.1 8.4 6.5 7.1 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Trypsin_2 PF13365.6 EFX02162.1 - 0.0096 16.8 0.1 1.9 9.4 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.26 EFX02162.1 - 0.093 12.5 0.8 0.21 11.3 0.7 1.7 1 1 0 1 1 1 0 Trypsin Peptidase_S3 PF00944.19 EFX02162.1 - 0.16 11.8 0.2 0.32 10.8 0.2 1.4 1 0 0 1 1 1 0 Alphavirus core protein Cu-oxidase_3 PF07732.15 EFX02163.1 - 1.8e-45 153.8 0.9 1.9e-43 147.2 0.0 3.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX02163.1 - 1.4e-33 115.5 2.8 1.9e-30 105.4 0.3 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX02163.1 - 8.9e-13 48.7 0.0 4.7e-12 46.3 0.0 2.0 2 0 0 2 2 2 1 Multicopper oxidase Fungal_trans PF04082.18 EFX02164.1 - 6.5e-06 25.4 0.0 1.5e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain CENP-L PF13092.6 EFX02165.1 - 1.4e-49 168.4 0.0 4.5e-49 166.8 0.0 1.8 2 0 0 2 2 2 1 Kinetochore complex Sim4 subunit Fta1 NAD_binding_7 PF13241.6 EFX02165.1 - 1.6e-33 115.2 0.0 3.8e-33 114.0 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EFX02165.1 - 2.6e-25 87.8 0.0 4.2e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EFX02165.1 - 2.2e-13 49.4 0.1 7.5e-13 47.7 0.0 2.0 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 EFX02165.1 - 0.0016 17.8 0.1 0.0025 17.1 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EFX02165.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase LSDAT_prok PF18171.1 EFX02165.1 - 0.033 13.4 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote ThiF PF00899.21 EFX02165.1 - 0.05 13.0 1.2 0.054 12.8 0.0 1.6 2 0 0 2 2 2 0 ThiF family MFS_1 PF07690.16 EFX02166.1 - 2.4e-35 122.1 54.6 1.1e-12 47.6 24.9 3.4 2 1 2 4 4 4 3 Major Facilitator Superfamily Tmemb_18A PF09771.9 EFX02166.1 - 5.7 7.4 5.5 2.3 8.6 2.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 188 DAHP_synth_1 PF00793.20 EFX02167.1 - 5.7e-105 350.1 0.1 6.5e-105 349.9 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Vps35 PF03635.17 EFX02169.1 - 0 1017.3 0.4 0 1017.1 0.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Mito_carr PF00153.27 EFX02170.1 - 3.1e-45 152.0 4.5 3.9e-19 68.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Putative_PNPOx PF01243.20 EFX02171.1 - 3.1e-12 46.5 0.1 1.9e-11 44.0 0.1 2.0 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EFX02171.1 - 0.026 14.5 0.0 0.17 11.9 0.0 2.0 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Myb_DNA-binding PF00249.31 EFX02173.1 - 3.3e-09 36.8 0.2 4.4e-07 30.0 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX02173.1 - 2.4e-05 24.5 1.7 6.1e-05 23.2 0.4 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.8 EFX02173.1 - 0.0029 17.7 0.1 0.02 15.0 0.0 2.2 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Glycos_transf_3 PF00591.21 EFX02173.1 - 0.096 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain ABC_tran PF00005.27 EFX02174.1 - 3.7e-46 157.0 0.0 1.6e-23 83.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFX02174.1 - 2.8e-28 99.3 24.7 7.3e-20 71.7 12.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EFX02174.1 - 1.2e-07 31.9 0.0 0.36 10.6 0.0 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFX02174.1 - 5.9e-07 29.8 0.1 0.015 15.6 0.0 2.9 4 0 0 4 4 2 2 AAA domain AAA_29 PF13555.6 EFX02174.1 - 5.6e-06 26.0 0.2 0.14 11.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFX02174.1 - 9.9e-06 26.0 0.0 0.009 16.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 EFX02174.1 - 1.7e-05 24.4 0.5 1.5 8.2 0.0 4.1 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFX02174.1 - 0.00011 22.1 0.2 0.16 11.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFX02174.1 - 0.00034 20.7 0.1 0.64 10.1 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase NB-ARC PF00931.22 EFX02174.1 - 0.0018 17.5 0.4 0.15 11.2 0.1 2.7 2 1 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 EFX02174.1 - 0.0018 18.8 0.0 0.54 10.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFX02174.1 - 0.0046 17.1 0.0 1.2 9.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 EFX02174.1 - 0.0067 16.1 0.1 0.24 11.0 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 EFX02174.1 - 0.0089 16.1 0.1 0.43 10.6 0.0 2.3 2 0 0 2 2 2 1 Dynamin family RNA_helicase PF00910.22 EFX02174.1 - 0.0093 16.3 0.0 7.6 7.0 0.0 3.2 3 0 0 3 3 3 0 RNA helicase AAA PF00004.29 EFX02174.1 - 0.011 16.2 0.0 0.064 13.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFX02174.1 - 0.011 15.6 0.6 0.77 9.7 0.1 2.5 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.6 EFX02174.1 - 0.013 15.7 3.4 5.2 7.4 0.1 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EFX02174.1 - 0.025 15.1 0.3 6.6 7.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFX02174.1 - 0.037 13.9 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFX02174.1 - 0.04 13.4 0.1 2.5 7.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFX02174.1 - 0.044 13.8 0.1 1.5 8.8 0.0 3.2 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EFX02174.1 - 0.049 13.3 2.6 5.7 6.6 0.0 3.6 4 0 0 4 4 4 0 AAA domain T2SSE PF00437.20 EFX02174.1 - 0.053 12.6 0.0 1.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_14 PF13173.6 EFX02174.1 - 0.063 13.3 0.0 0.54 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFX02174.1 - 0.089 12.4 4.1 0.86 9.1 0.0 3.4 4 0 0 4 4 3 0 AAA domain cobW PF02492.19 EFX02174.1 - 0.12 11.9 1.3 2.6 7.6 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 EFX02174.1 - 0.15 11.8 0.5 13 5.5 0.0 3.2 4 0 0 4 4 3 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 EFX02174.1 - 0.16 11.7 0.3 8.4 6.0 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Adeno_IVa2 PF02456.15 EFX02174.1 - 0.26 10.0 0.1 1.6 7.4 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_19 PF13245.6 EFX02174.1 - 0.52 10.6 2.4 9.1 6.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 EFX02174.1 - 0.54 10.2 1.2 1.8 8.5 0.1 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain DIOX_N PF14226.6 EFX02175.1 - 2.3e-18 67.1 0.0 4.8e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX02175.1 - 1.1e-17 64.3 0.0 1.7e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily XhlA PF10779.9 EFX02176.1 - 2.1 8.6 3.8 6.4 7.1 0.1 2.8 2 0 0 2 2 2 0 Haemolysin XhlA Aldolase_II PF00596.21 EFX02177.1 - 1.9e-43 148.6 0.0 2.5e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain MFS_1 PF07690.16 EFX02179.1 - 3.8e-48 164.2 55.6 7.3e-47 160.0 55.6 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX02179.1 - 1.9e-22 79.5 15.2 1.9e-22 79.5 15.2 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFX02179.1 - 3.4e-14 52.6 14.0 3.4e-14 52.6 14.0 2.7 2 1 0 3 3 3 1 Sugar (and other) transporter Ank_2 PF12796.7 EFX02179.1 - 0.00013 22.5 0.1 0.00085 19.9 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX02179.1 - 0.0013 19.0 0.3 0.24 12.0 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat DUF1768 PF08719.11 EFX02180.1 - 1.1e-52 178.5 0.0 1.3e-52 178.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) LMWPc PF01451.21 EFX02181.1 - 5e-37 127.4 0.0 5.6e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Ytp1 PF10355.9 EFX02184.1 - 1.2e-66 224.8 20.9 1.2e-66 224.8 20.9 2.1 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EFX02184.1 - 3.5e-35 120.0 3.4 3.5e-35 120.0 3.4 3.4 5 0 0 5 5 5 1 Domain of unknown function (DUF2427) UbiA PF01040.18 EFX02185.1 - 7e-59 199.2 18.6 7e-59 199.2 18.6 1.8 1 1 1 2 2 2 1 UbiA prenyltransferase family Aminotran_5 PF00266.19 EFX02186.1 - 2.1e-24 86.2 0.0 1.3e-15 57.3 0.0 3.1 3 0 0 3 3 3 3 Aminotransferase class-V DUF442 PF04273.13 EFX02186.1 - 0.13 12.4 0.9 10 6.3 0.2 2.5 2 0 0 2 2 2 0 Putative phosphatase (DUF442) Phosphoesterase PF04185.14 EFX02187.1 - 5.4e-76 256.1 2.3 5.4e-76 256.1 2.3 1.4 2 0 0 2 2 2 1 Phosphoesterase family Fascin PF06268.13 EFX02187.1 - 0.0037 17.5 0.4 0.014 15.7 0.4 2.0 1 1 0 1 1 1 1 Fascin domain RicinB_lectin_2 PF14200.6 EFX02187.1 - 0.0047 17.6 4.1 0.069 13.9 0.3 3.6 2 2 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like DEAD PF00270.29 EFX02189.1 - 2.7e-16 59.8 0.0 7.3e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFX02189.1 - 3.1e-12 46.8 0.3 2.5e-11 43.9 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFX02189.1 - 7e-07 29.6 0.0 1.9e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 EFX02189.1 - 0.027 13.9 0.0 0.063 12.7 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DNA_pack_N PF02500.15 EFX02189.1 - 0.048 13.5 0.7 0.22 11.3 0.0 2.2 2 0 0 2 2 2 0 Probable DNA packing protein, N-terminus SicP-binding PF09119.10 EFX02189.1 - 0.053 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 SicP binding Elongin_A PF06881.11 EFX02189.1 - 1.1 9.8 7.8 7.2 7.2 0.6 2.7 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Vps16_N PF04841.13 EFX02190.1 - 1.4e-96 323.7 0.0 1.9e-96 323.4 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EFX02190.1 - 2.4e-79 266.7 0.0 3.8e-79 266.1 0.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EFX02190.1 - 0.07 13.4 0.0 0.58 10.5 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Oxysterol_BP PF01237.18 EFX02192.1 - 7.9e-128 426.4 0.0 7.9e-128 426.4 0.0 2.6 3 0 0 3 3 3 1 Oxysterol-binding protein Ank_2 PF12796.7 EFX02192.1 - 5.1e-17 62.2 4.1 1.2e-08 35.5 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFX02192.1 - 2e-16 59.8 2.6 1.5e-08 34.7 0.8 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFX02192.1 - 3.4e-13 49.4 2.9 0.00015 22.1 0.3 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFX02192.1 - 5.4e-13 49.2 0.2 4.4e-08 33.5 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) PH PF00169.29 EFX02192.1 - 2e-11 44.3 0.7 3.7e-11 43.5 0.7 1.5 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.6 EFX02192.1 - 1.1e-09 37.7 1.5 0.00093 19.5 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat PH_8 PF15409.6 EFX02192.1 - 9.3e-08 32.3 1.0 2.4e-07 30.9 1.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFX02192.1 - 3e-05 24.4 3.0 0.0001 22.7 3.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain MucB_RseB_C PF17188.4 EFX02192.1 - 0.074 13.3 0.0 0.23 11.7 0.0 1.8 1 0 0 1 1 1 0 MucB/RseB C-terminal domain FMO-like PF00743.19 EFX02193.1 - 2.5e-39 135.1 0.1 6.7e-21 74.3 0.1 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX02193.1 - 6.5e-19 68.3 0.1 7.4e-13 48.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX02193.1 - 7.2e-13 48.4 0.0 3.8e-12 46.0 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX02193.1 - 1.1e-11 44.9 3.8 7e-06 25.9 0.2 3.2 2 1 1 3 3 3 3 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX02193.1 - 1.6e-10 41.2 1.5 2.4e-08 34.1 1.3 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EFX02193.1 - 1e-07 31.5 5.1 1.8e-05 24.1 0.1 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFX02193.1 - 3.2e-07 30.5 0.0 8.7e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFX02193.1 - 4.6e-06 27.1 3.6 0.0013 19.2 1.1 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX02193.1 - 2.7e-05 23.6 0.8 0.029 13.7 0.1 2.8 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Thi4 PF01946.17 EFX02193.1 - 0.0017 17.7 0.6 0.003 16.8 0.6 1.3 1 0 0 1 1 1 1 Thi4 family IlvN PF07991.12 EFX02193.1 - 0.0026 17.4 0.0 0.0049 16.4 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EFX02193.1 - 0.0057 16.7 0.6 0.025 14.7 0.1 2.3 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EFX02193.1 - 0.0063 15.3 3.4 0.028 13.2 0.8 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EFX02193.1 - 0.0087 15.4 0.9 0.018 14.4 0.1 1.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_2 PF03446.15 EFX02193.1 - 0.0096 16.1 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EFX02193.1 - 0.014 15.3 0.8 0.027 14.4 0.8 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EFX02193.1 - 0.024 13.7 1.0 0.038 13.1 1.0 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 EFX02193.1 - 0.071 12.4 1.1 0.18 11.1 1.1 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DUF3742 PF12553.8 EFX02193.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) FAD_binding_3 PF01494.19 EFX02193.1 - 0.17 11.1 1.6 0.24 10.6 0.3 1.8 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 EFX02193.1 - 0.24 10.4 0.3 0.43 9.6 0.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A MFS_1 PF07690.16 EFX02194.1 - 1.2e-05 24.4 22.4 0.00054 19.0 1.1 3.2 2 2 1 3 3 3 2 Major Facilitator Superfamily Ilm1 PF10311.9 EFX02194.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 DUF4017 PF13209.6 EFX02194.1 - 0.18 11.8 2.8 0.4 10.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) SIR2 PF02146.17 EFX02195.1 - 1e-32 113.5 0.0 1.7e-10 41.1 0.0 3.3 2 1 1 3 3 3 3 Sir2 family Abdominal-A PF12407.8 EFX02195.1 - 1.3 8.6 5.7 0.18 11.4 0.3 2.4 2 0 0 2 2 2 0 Homeobox protein WSC PF01822.19 EFX02197.1 - 6.7e-106 346.7 96.9 5.5e-19 68.1 12.3 6.9 6 0 0 6 6 6 6 WSC domain NETI PF14044.6 EFX02197.1 - 0.0032 17.2 1.7 21 4.9 0.0 4.9 5 0 0 5 5 5 2 NETI protein DUF1573 PF07610.11 EFX02197.1 - 0.011 15.8 2.8 1.7 8.7 0.2 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1573) Mannosyl_trans PF05007.13 EFX02198.1 - 5.7e-69 232.9 1.0 5.7e-69 232.9 1.0 1.5 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EFX02198.1 - 1.2e-10 41.1 0.0 1.2e-10 41.1 0.0 2.0 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U Fmp27 PF10344.9 EFX02199.1 - 1.8e-202 674.9 0.0 4.1e-202 673.7 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 EFX02199.1 - 3.8e-202 672.4 0.5 2.4e-200 666.4 0.5 2.7 1 1 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 EFX02199.1 - 7.7e-170 565.9 0.0 1.4e-169 565.0 0.0 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EFX02199.1 - 3.8e-54 183.0 0.0 7.5e-54 182.1 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EFX02199.1 - 1.3e-53 181.1 0.1 2.8e-53 180.0 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EFX02199.1 - 1.6e-31 109.0 0.0 8.1e-30 103.6 0.0 3.3 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain Serine_rich PF08824.10 EFX02199.1 - 0.049 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Serine rich protein interaction domain ODC_AZ PF02100.17 EFX02200.1 - 1.5e-41 141.0 0.0 2.2e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme CPSase_L_D2 PF02786.17 EFX02201.1 - 1.6e-69 233.6 0.0 2.6e-69 233.0 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EFX02201.1 - 3.7e-36 123.5 0.0 7.7e-36 122.5 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 EFX02201.1 - 1.9e-34 118.5 0.0 4.2e-34 117.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 EFX02201.1 - 5.1e-15 55.1 0.6 1.5e-14 53.5 0.6 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 EFX02201.1 - 2.7e-06 27.1 0.0 6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFX02201.1 - 2.8e-06 27.0 0.0 7.1e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 EFX02201.1 - 0.00032 20.4 0.0 0.035 13.9 0.0 2.9 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 EFX02201.1 - 0.016 15.9 0.0 3.9 8.2 0.0 2.7 2 0 0 2 2 2 0 HlyD family secretion protein ATP-grasp_3 PF02655.14 EFX02201.1 - 0.018 15.1 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain HlyD_D23 PF16576.5 EFX02201.1 - 0.026 13.7 0.0 7 5.8 0.0 3.1 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_4 PF13535.6 EFX02201.1 - 0.077 12.6 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Glyco_hydro_3_C PF01915.22 EFX02203.1 - 1e-54 185.6 0.0 1.9e-54 184.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX02203.1 - 6.4e-40 137.5 0.0 1e-39 136.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX02203.1 - 8.3e-16 57.9 0.0 1.6e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EFX02203.1 - 2.7e-06 27.2 0.0 4.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 PA14 domain SQS_PSY PF00494.19 EFX02204.1 - 6.7e-40 137.2 0.0 1.7e-39 136.0 0.0 1.6 2 0 0 2 2 2 1 Squalene/phytoene synthase TFIIF_alpha PF05793.12 EFX02205.1 - 0.12 10.9 2.0 0.15 10.6 2.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PIG-S PF10510.9 EFX02206.1 - 3.4e-167 557.4 0.0 4e-167 557.2 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein SAM_3 PF18016.1 EFX02206.1 - 0.11 12.4 0.1 14 5.6 0.0 3.0 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) SUIM_assoc PF16619.5 EFX02206.1 - 3.5 7.7 9.2 0.18 11.9 2.3 2.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 GH131_N PF18271.1 EFX02207.1 - 8.2e-86 287.8 0.3 9.3e-86 287.7 0.3 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Cofilin_ADF PF00241.20 EFX02209.1 - 1.6e-20 73.1 0.0 2e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S9 PF00380.19 EFX02210.1 - 4.2e-33 114.4 0.0 4.8e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF3362 PF11842.8 EFX02210.1 - 0.068 13.5 0.0 0.095 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) TFR_dimer PF04253.15 EFX02211.1 - 2e-31 108.6 0.0 3.3e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EFX02211.1 - 1.9e-17 63.6 0.0 5.7e-17 62.1 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EFX02211.1 - 2.4e-13 49.9 0.0 5.2e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 PA domain SRP1_TIP1 PF00660.17 EFX02211.1 - 0.26 11.4 0.5 0.5 10.5 0.5 1.4 1 0 0 1 1 1 0 Seripauperin and TIP1 family FAD_binding_3 PF01494.19 EFX02212.1 - 1.7e-14 53.9 0.2 3.6e-14 52.8 0.2 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX02212.1 - 4.6e-07 29.7 0.9 8.3e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFX02212.1 - 1.3e-05 24.5 0.4 0.00018 20.7 0.4 2.2 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EFX02212.1 - 3.2e-05 23.3 0.6 0.00029 20.2 0.0 2.2 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX02212.1 - 0.0001 22.4 0.0 0.00032 20.9 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFX02212.1 - 0.00026 21.0 0.4 0.25 11.3 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EFX02212.1 - 0.0012 18.0 0.1 0.002 17.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFX02212.1 - 0.0044 15.8 0.1 0.013 14.2 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein SE PF08491.10 EFX02212.1 - 0.011 14.8 0.0 0.041 12.9 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase Thi4 PF01946.17 EFX02212.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EFX02212.1 - 0.02 14.2 0.1 0.048 12.9 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX02212.1 - 0.086 13.4 0.0 0.44 11.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Aldo_ket_red PF00248.21 EFX02213.1 - 2.8e-76 256.5 0.0 3.1e-76 256.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ketoacyl-synt_C PF02801.22 EFX02213.1 - 0.12 12.4 0.1 0.28 11.2 0.0 1.6 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Abhydrolase_2 PF02230.16 EFX02214.1 - 1.8e-60 204.5 0.0 2.1e-60 204.2 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFX02214.1 - 1.2e-10 41.1 0.2 0.00039 19.8 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFX02214.1 - 1.1e-07 31.6 0.4 1.8e-05 24.3 0.0 2.5 2 1 1 3 3 3 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFX02214.1 - 1.1e-07 31.8 0.4 0.0079 15.9 1.4 3.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX02214.1 - 7.1e-07 30.0 4.7 1.4e-06 29.1 4.7 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 EFX02214.1 - 4e-06 26.7 0.0 4.9e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EFX02214.1 - 1.7e-05 24.8 0.1 0.025 14.4 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 EFX02214.1 - 1.9e-05 24.3 0.0 2.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.20 EFX02214.1 - 0.0024 17.5 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DUF2974 PF11187.8 EFX02214.1 - 0.0047 16.5 0.1 0.012 15.1 0.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EFX02214.1 - 0.015 15.2 0.0 0.085 12.7 0.0 2.0 1 1 0 1 1 1 0 Lipase (class 3) AXE1 PF05448.12 EFX02214.1 - 0.038 12.7 0.0 0.057 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Cutinase PF01083.22 EFX02214.1 - 0.049 13.6 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydrolase_4 PF08386.10 EFX02214.1 - 0.088 12.9 0.0 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 TAP-like protein Abhydrolase_5 PF12695.7 EFX02214.1 - 0.2 11.4 0.0 0.33 10.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Gly_transf_sug PF04488.15 EFX02215.1 - 2.6e-14 53.6 0.0 6e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Methyltransf_23 PF13489.6 EFX02216.1 - 2.8e-17 63.0 0.0 4.5e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02216.1 - 4.3e-09 37.0 0.0 9.6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02216.1 - 1.2e-06 28.4 0.0 1.2e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02216.1 - 1.5e-06 28.8 0.0 4.3e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02216.1 - 7.9e-05 23.2 0.0 0.00015 22.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX02216.1 - 0.0016 18.0 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX02216.1 - 0.0045 16.5 0.0 0.0076 15.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EFX02216.1 - 0.005 16.3 0.0 0.0068 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EFX02216.1 - 0.038 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.12 EFX02216.1 - 0.052 13.3 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 EFX02216.1 - 0.053 12.8 0.0 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family RRM_1 PF00076.22 EFX02217.1 - 3.5e-12 46.0 0.0 8.5e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BAF1_ABF1 PF04684.13 EFX02217.1 - 0.017 14.2 12.2 0.02 14.0 12.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Mitofilin PF09731.9 EFX02217.1 - 0.17 10.7 28.8 0.2 10.4 28.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Asp-B-Hydro_N PF05279.11 EFX02217.1 - 4.7 7.2 28.8 7.8 6.5 28.8 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SAPS PF04499.15 EFX02217.1 - 8.8 5.0 9.2 11 4.7 9.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TauD PF02668.16 EFX02219.1 - 2.1e-32 113.0 0.1 3.6e-32 112.2 0.1 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Serglycin PF04360.12 EFX02220.1 - 0.2 11.6 0.6 0.35 10.8 0.6 1.3 1 0 0 1 1 1 0 Serglycin TPR_12 PF13424.6 EFX02220.1 - 0.29 11.5 5.9 2.3 8.6 0.9 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat S1-P1_nuclease PF02265.16 EFX02221.1 - 4.7e-71 239.6 0.0 5.4e-71 239.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease TetR_C_27 PF17935.1 EFX02221.1 - 0.046 13.8 0.1 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain 4HBT PF03061.22 EFX02222.1 - 8.2e-18 64.5 0.3 1.4e-17 63.8 0.3 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EFX02222.1 - 0.014 15.6 1.0 0.018 15.3 0.0 1.6 2 0 0 2 2 2 0 Thioesterase-like superfamily DUF4199 PF13858.6 EFX02223.1 - 0.073 13.5 3.5 0.11 12.9 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF202 PF02656.15 EFX02223.1 - 0.79 10.2 3.9 1.7 9.2 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Dicty_CAR PF05462.11 EFX02224.1 - 9.9e-07 28.2 2.8 9.9e-07 28.2 2.8 1.9 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor Git3 PF11710.8 EFX02224.1 - 0.0007 19.4 2.2 0.0007 19.4 2.2 1.7 1 1 1 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 EFX02224.1 - 0.0035 16.7 8.6 0.0051 16.2 8.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 EFX02224.1 - 0.11 11.8 3.4 0.11 11.8 2.0 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2842 PF11003.8 EFX02224.1 - 1.5 9.1 10.0 2 8.7 2.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2842) MAP65_ASE1 PF03999.12 EFX02226.1 - 1.5e-67 228.7 13.5 2.1e-67 228.2 3.0 2.0 2 0 0 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) DUF3080 PF11279.8 EFX02226.1 - 0.0084 15.4 0.1 0.027 13.7 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) SF-assemblin PF06705.11 EFX02226.1 - 0.0092 15.3 0.3 0.0092 15.3 0.3 2.5 3 0 0 3 3 3 2 SF-assemblin/beta giardin Ank_2 PF12796.7 EFX02227.1 - 2.4e-97 319.6 28.9 8.1e-18 64.8 1.2 8.9 3 2 5 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.30 EFX02227.1 - 6.1e-78 254.1 78.3 2.9e-06 27.5 0.2 17.3 16 1 1 17 17 17 16 Ankyrin repeat Ank_4 PF13637.6 EFX02227.1 - 1.9e-77 254.7 25.2 2.3e-09 37.6 0.2 12.6 4 2 8 14 14 14 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX02227.1 - 2.5e-71 227.1 29.9 5.5e-05 23.3 0.0 17.8 17 0 0 17 17 17 15 Ankyrin repeat Ank_5 PF13857.6 EFX02227.1 - 6.2e-71 233.5 45.1 1.9e-07 31.2 0.3 15.1 5 4 11 16 16 16 14 Ankyrin repeats (many copies) HET PF06985.11 EFX02227.1 - 3.8e-51 173.3 0.0 2.7e-26 92.7 0.0 2.7 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) EST1_DNA_bind PF10373.9 EFX02228.1 - 8.7e-10 38.5 0.0 1.5e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Fungal_trans PF04082.18 EFX02229.1 - 6.8e-24 84.3 0.1 1.2e-23 83.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02229.1 - 4.5e-09 36.3 5.0 9e-09 35.3 5.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EFX02230.1 - 0.0051 16.9 3.0 0.0093 16.1 3.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YscO PF07321.12 EFX02230.1 - 0.069 13.1 0.8 0.12 12.4 0.8 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO HalX PF08663.10 EFX02230.1 - 0.091 13.1 1.9 0.27 11.6 0.7 2.2 2 0 0 2 2 2 0 HalX domain Meth_synt_2 PF01717.18 EFX02231.1 - 2.9e-11 43.2 0.0 4.1e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EFX02231.1 - 0.088 12.3 0.0 0.21 11.0 0.0 1.6 2 0 0 2 2 2 0 Cobalamin-independent synthase, N-terminal domain DUF5518 PF17647.1 EFX02232.1 - 0.0059 16.7 0.8 0.049 13.8 0.1 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5518) Mucin15 PF15672.5 EFX02232.1 - 0.012 15.1 7.2 1.7 8.0 7.2 2.1 1 1 0 1 1 1 0 Cell-membrane associated Mucin15 Trp_oprn_chp PF09534.10 EFX02232.1 - 0.02 14.7 0.2 0.032 14.0 0.2 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF456 PF04306.13 EFX02232.1 - 0.02 15.2 0.1 0.02 15.2 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF456) Thiolase_N PF00108.23 EFX02233.1 - 6.9e-67 225.5 0.1 9.4e-67 225.1 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFX02233.1 - 1.6e-42 144.0 0.2 3.8e-42 142.8 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EFX02233.1 - 0.015 15.1 0.4 1.2 9.1 0.1 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 EFX02233.1 - 0.048 13.8 0.7 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Ribosomal_L50 PF10501.9 EFX02234.1 - 6.4e-18 64.9 0.0 9.9e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal subunit 39S RTC PF01137.21 EFX02235.1 - 5.8e-51 172.8 0.4 1.8e-50 171.2 0.4 1.7 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase Semialdhyde_dh PF01118.24 EFX02235.1 - 3.5e-28 98.5 0.0 1.3e-27 96.6 0.0 2.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAT PF04768.13 EFX02235.1 - 5e-26 91.4 0.1 9.8e-26 90.4 0.1 1.4 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase TFIIB PF00382.19 EFX02236.1 - 1.4e-29 101.9 1.1 9.4e-18 64.0 0.2 2.8 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EFX02236.1 - 1.9e-22 79.5 0.7 1.9e-22 79.5 0.7 2.9 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 EFX02236.1 - 2.4e-05 24.1 2.1 0.083 12.6 0.2 2.4 1 1 0 2 2 2 2 Cyclin, N-terminal domain TF_Zn_Ribbon PF08271.12 EFX02236.1 - 0.065 12.8 1.7 0.18 11.4 1.7 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding zf-AD PF07776.15 EFX02236.1 - 0.12 12.6 0.1 0.72 10.1 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) Beta-lactamase PF00144.24 EFX02237.1 - 5.7e-53 180.3 0.0 8.2e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EFX02237.1 - 0.00022 20.7 0.0 0.002 17.6 0.0 2.1 2 0 0 2 2 2 1 D-alanyl-D-alanine carboxypeptidase ABC_membrane PF00664.23 EFX02238.1 - 4.4e-69 233.2 16.3 3.4e-34 118.7 0.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFX02238.1 - 6.6e-56 188.6 0.0 2e-27 96.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFX02238.1 - 7.4e-12 45.7 0.0 0.0034 17.2 0.0 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX02238.1 - 1.4e-11 44.3 0.3 0.17 11.3 0.0 4.3 3 1 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFX02238.1 - 5.7e-09 35.6 0.2 0.0032 17.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EFX02238.1 - 1.1e-07 32.0 0.0 0.019 14.7 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFX02238.1 - 4.2e-07 30.3 0.1 0.15 12.4 0.0 3.9 2 2 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFX02238.1 - 4.3e-06 26.6 0.0 0.18 11.5 0.0 3.2 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFX02238.1 - 5.7e-06 26.8 1.4 0.051 14.0 0.1 3.2 2 2 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 EFX02238.1 - 3e-05 24.3 0.6 0.028 14.5 0.1 2.7 3 0 0 3 3 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 EFX02238.1 - 8e-05 22.6 0.0 0.49 10.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 EFX02238.1 - 0.00019 21.6 2.5 2 8.7 0.2 4.1 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 EFX02238.1 - 0.00022 21.8 0.0 0.29 11.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EFX02238.1 - 0.00075 20.1 0.0 0.97 9.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EFX02238.1 - 0.00099 19.3 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EFX02238.1 - 0.0013 18.3 0.0 0.78 9.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EFX02238.1 - 0.0017 17.6 0.0 1.2 8.2 0.0 2.6 3 0 0 3 3 3 2 NB-ARC domain MMR_HSR1 PF01926.23 EFX02238.1 - 0.0019 18.3 0.0 0.96 9.6 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 EFX02238.1 - 0.0023 17.8 0.3 1.4 8.9 0.0 3.4 3 0 0 3 3 3 1 NACHT domain AAA_5 PF07728.14 EFX02238.1 - 0.0056 16.7 0.0 10 6.1 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 EFX02238.1 - 0.0057 16.0 0.8 0.68 9.2 0.0 3.0 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_14 PF13173.6 EFX02238.1 - 0.0091 16.0 0.0 17 5.4 0.0 3.8 4 0 0 4 4 4 0 AAA domain Zeta_toxin PF06414.12 EFX02238.1 - 0.0092 15.3 0.0 4.8 6.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin DUF3987 PF13148.6 EFX02238.1 - 0.012 14.7 0.0 4.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Ploopntkinase3 PF18751.1 EFX02238.1 - 0.019 14.9 0.0 2.2 8.1 0.0 2.8 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 APS_kinase PF01583.20 EFX02238.1 - 0.021 14.7 0.3 7.7 6.4 0.0 3.0 3 0 0 3 3 2 0 Adenylylsulphate kinase T2SSE PF00437.20 EFX02238.1 - 0.029 13.4 0.0 0.76 8.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein G-alpha PF00503.20 EFX02238.1 - 0.049 12.8 0.0 4.5 6.3 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 EFX02238.1 - 0.1 12.1 0.0 6.8 6.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFX02238.1 - 0.14 12.6 0.0 19 5.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase CbiA PF01656.23 EFX02238.1 - 0.15 12.1 0.1 6.9 6.7 0.0 2.5 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 EFX02238.1 - 0.16 11.7 0.1 10 5.8 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.14 EFX02238.1 - 0.19 11.7 0.0 7 6.5 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 EFX02238.1 - 0.23 11.1 0.0 18 5.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EFX02238.1 - 0.23 11.5 0.6 25 4.9 0.3 2.6 2 0 0 2 2 2 0 Dynamin family AAA_13 PF13166.6 EFX02238.1 - 0.26 9.9 0.0 3.5 6.2 0.0 2.4 3 0 0 3 3 3 0 AAA domain Sugar_tr PF00083.24 EFX02239.1 - 2.5e-89 300.2 20.7 3e-89 300.0 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX02239.1 - 3.7e-24 85.3 59.9 1.2e-22 80.3 30.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily EMP70 PF02990.16 EFX02239.1 - 0.1 11.2 0.0 0.1 11.2 0.0 2.9 2 1 0 2 2 2 0 Endomembrane protein 70 SNF2_N PF00176.23 EFX02240.1 - 2.1e-65 220.8 1.6 4.5e-65 219.7 1.6 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EFX02240.1 - 1.8e-48 164.3 19.3 1.8e-48 164.3 19.3 4.4 3 1 0 4 4 4 1 DNA-binding domain Helicase_C PF00271.31 EFX02240.1 - 1.9e-19 70.0 0.0 6.2e-19 68.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX02240.1 - 5e-08 33.1 0.6 2.6e-07 30.8 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFX02240.1 - 0.017 14.3 0.1 0.19 10.9 0.0 2.7 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 baeRF_family12 PF18856.1 EFX02240.1 - 0.029 15.0 0.1 0.029 15.0 0.1 6.3 7 0 0 7 7 7 0 Bacterial archaeo-eukaryotic release factor family 12 Fe_hyd_lg_C PF02906.14 EFX02240.1 - 0.059 13.0 3.8 0.044 13.4 1.5 1.9 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain DDE_Tnp_IS1 PF03400.13 EFX02240.1 - 0.2 12.0 0.9 0.85 10.0 0.9 2.1 1 0 0 1 1 1 0 IS1 transposase ADH_N PF08240.12 EFX02241.1 - 5.5e-26 90.6 2.8 8.8e-26 89.9 2.8 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX02241.1 - 7.8e-14 51.8 0.1 2.1e-13 50.4 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EFX02241.1 - 2e-05 24.0 0.1 3.4e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EFX02241.1 - 0.0033 18.5 0.0 0.0051 17.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX02241.1 - 0.11 11.7 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Gp_dh_N PF00044.24 EFX02241.1 - 0.16 12.3 0.1 12 6.3 0.0 2.4 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Pkinase PF00069.25 EFX02242.1 - 3.8e-69 233.0 0.0 4.7e-69 232.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02242.1 - 1.4e-31 109.7 0.0 2.1e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFX02242.1 - 0.01 14.8 0.0 0.019 13.9 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain DUF2075 PF09848.9 EFX02242.1 - 0.047 12.9 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Kdo PF06293.14 EFX02242.1 - 0.048 13.0 0.1 0.099 12.0 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX02242.1 - 0.11 12.4 1.9 0.17 11.8 0.0 2.2 3 1 0 3 3 3 0 Phosphotransferase enzyme family A_deaminase PF00962.22 EFX02243.1 - 6.5e-29 101.3 0.0 7.9e-29 101.0 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Ysc84 PF04366.12 EFX02245.1 - 4.2e-44 149.4 0.1 6.3e-44 148.8 0.1 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator Phosducin PF02114.16 EFX02246.1 - 2.3e-16 59.6 0.0 3.6e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Phosducin Sdh_cyt PF01127.22 EFX02247.1 - 6.9e-18 64.8 3.0 1.3e-17 63.9 3.0 1.4 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit NAD_binding_10 PF13460.6 EFX02248.1 - 1.9e-13 50.7 0.0 4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFX02248.1 - 1.7e-12 47.4 0.0 2.5e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFX02248.1 - 0.00019 21.0 0.2 0.00037 20.0 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EFX02248.1 - 0.0025 17.9 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EFX02248.1 - 0.012 16.2 0.6 0.03 14.9 0.2 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EFX02248.1 - 0.02 14.5 0.1 0.033 13.8 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DapB_N PF01113.20 EFX02248.1 - 0.063 13.4 0.2 0.15 12.2 0.1 1.6 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EFX02248.1 - 0.065 13.7 0.1 0.12 12.8 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 EFX02248.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 KR domain K_oxygenase PF13434.6 EFX02249.1 - 3e-11 43.1 0.0 3.3e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFX02249.1 - 4.6e-11 42.5 0.0 9.7e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFX02249.1 - 8.5e-09 34.4 0.0 6.2e-08 31.5 0.0 1.9 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFX02249.1 - 2.1e-08 33.8 0.0 4.7e-08 32.6 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX02249.1 - 4.2e-06 26.6 0.4 0.014 15.0 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX02249.1 - 0.00035 20.6 0.3 0.22 11.5 0.1 3.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFX02249.1 - 0.00049 20.3 0.0 0.0014 18.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFX02249.1 - 0.0013 18.1 0.1 0.011 15.0 0.0 2.3 3 0 0 3 3 3 1 Thi4 family ThiF PF00899.21 EFX02250.1 - 1.3e-37 129.5 0.0 2.3e-37 128.6 0.0 1.3 1 0 0 1 1 1 1 ThiF family Ldh_1_N PF00056.23 EFX02250.1 - 0.025 14.7 0.2 0.048 13.8 0.2 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain TrkA_N PF02254.18 EFX02250.1 - 0.026 14.8 0.0 0.23 11.7 0.0 2.5 1 1 1 2 2 2 0 TrkA-N domain DUF2252 PF10009.9 EFX02250.1 - 0.028 13.5 2.3 0.044 12.9 2.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) UDPG_MGDP_dh_N PF03721.14 EFX02250.1 - 0.049 13.2 0.1 0.095 12.3 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFX02250.1 - 0.12 12.7 7.3 0.049 13.9 1.3 3.0 3 1 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain Melibiase_2 PF16499.5 EFX02250.1 - 0.14 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Alpha galactosidase A 3HCDH_N PF02737.18 EFX02250.1 - 0.3 11.0 2.1 0.29 11.0 0.1 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sigma70_r1_2 PF00140.20 EFX02250.1 - 0.49 10.5 3.3 2.8 8.0 3.3 2.3 1 1 0 1 1 1 0 Sigma-70 factor, region 1.2 DAO PF01266.24 EFX02250.1 - 0.78 9.3 8.0 0.6 9.6 0.7 2.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Peptidase_S24 PF00717.23 EFX02252.1 - 7.7e-07 29.0 0.0 1.2e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like NmrA PF05368.13 EFX02253.1 - 4.7e-40 137.6 0.0 5.7e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX02253.1 - 5e-14 52.6 0.6 8.3e-14 51.9 0.6 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFX02253.1 - 1.2e-05 24.9 0.2 1.7e-05 24.4 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX02253.1 - 8.1e-05 21.8 0.0 0.00011 21.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EFX02253.1 - 0.014 15.6 0.1 0.025 14.8 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 EFX02253.1 - 0.05 12.7 0.1 0.074 12.2 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Peptidase_S66 PF02016.15 EFX02254.1 - 1e-25 90.2 0.0 1.4e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 LD-carboxypeptidase N-terminal domain Peptidase_S66C PF17676.1 EFX02254.1 - 3.4e-23 82.5 0.0 4.9e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 LD-carboxypeptidase C-terminal domain adh_short PF00106.25 EFX02255.1 - 2.5e-37 128.2 0.7 5.8e-37 127.1 0.7 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02255.1 - 7.1e-29 101.0 0.6 1.4e-28 100.1 0.6 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02255.1 - 3.6e-12 46.5 0.3 5.3e-12 46.0 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX02255.1 - 7.1e-05 22.4 0.6 0.00041 19.9 0.6 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX02255.1 - 0.013 14.9 0.2 0.45 9.8 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFX02255.1 - 0.014 15.3 3.6 0.043 13.7 3.6 1.9 1 1 0 1 1 1 0 NAD(P)H-binding DUF1776 PF08643.10 EFX02255.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Semialdhyde_dhC PF02774.18 EFX02256.1 - 9.9e-37 126.8 0.0 1.3e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EFX02256.1 - 3.4e-28 98.5 0.0 5.9e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 EFX02256.1 - 0.054 14.2 0.0 0.13 13.0 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.20 EFX02256.1 - 0.056 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus TOM13 PF08219.11 EFX02257.1 - 8.3e-37 125.0 0.1 1.1e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 FAD_binding_7 PF03441.14 EFX02259.1 - 1.1e-42 145.9 0.6 3.1e-42 144.3 0.6 1.8 1 1 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EFX02259.1 - 2.1e-13 50.6 0.0 2.3e-12 47.2 0.0 2.4 2 0 0 2 2 2 1 DNA photolyase P63C PF10546.9 EFX02259.1 - 0.029 14.9 0.0 0.12 13.0 0.0 2.0 1 0 0 1 1 1 0 P63C domain TP_methylase PF00590.20 EFX02262.1 - 5.6e-44 150.6 2.6 1.5e-43 149.3 2.6 1.7 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 EFX02262.1 - 1.2e-11 43.8 1.0 2e-11 43.1 0.1 1.9 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central NAD_binding_7 PF13241.6 EFX02262.1 - 4.9e-09 36.6 0.0 1.1e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EFX02262.1 - 8.7e-09 34.9 0.3 7.1e-07 28.8 0.1 2.3 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal Alk_phosphatase PF00245.20 EFX02263.1 - 6.1e-103 345.0 0.0 8.5e-103 344.5 0.0 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EFX02263.1 - 2.7e-05 23.6 0.0 5.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily RskA PF10099.9 EFX02263.1 - 0.025 14.9 1.6 0.044 14.1 1.6 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA RmlD_sub_bind PF04321.17 EFX02264.1 - 3.1e-15 56.1 0.0 6.1e-15 55.1 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EFX02264.1 - 1.6e-13 50.7 0.0 2.7e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFX02264.1 - 3.2e-05 23.2 0.0 5.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFX02264.1 - 0.00022 20.7 0.0 0.00047 19.7 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFX02264.1 - 0.0035 16.4 0.0 0.008 15.2 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Macro PF01661.21 EFX02264.1 - 0.055 13.5 0.2 0.17 11.9 0.0 1.9 3 0 0 3 3 3 0 Macro domain ATG16 PF08614.11 EFX02265.1 - 8.3e-53 179.6 22.0 9.9e-53 179.4 22.0 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 EFX02265.1 - 0.0023 17.4 10.8 0.0025 17.3 10.8 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF4201 PF13870.6 EFX02265.1 - 0.0046 16.7 10.1 0.0046 16.7 10.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) APG6_N PF17675.1 EFX02265.1 - 0.028 14.9 2.0 0.028 14.9 2.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region GIT_CC PF16559.5 EFX02265.1 - 0.32 10.9 0.0 0.32 10.9 0.0 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor UPF0242 PF06785.11 EFX02265.1 - 0.68 10.0 12.4 2 8.5 5.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TSC22 PF01166.18 EFX02265.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.3 2 1 1 3 3 3 0 TSC-22/dip/bun family DivIC PF04977.15 EFX02265.1 - 2.3 8.1 12.2 5.2 6.9 0.0 3.2 3 0 0 3 3 3 0 Septum formation initiator adh_short PF00106.25 EFX02267.1 - 6.4e-33 113.9 0.0 3e-32 111.7 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02267.1 - 2.3e-26 92.8 0.8 3.6e-12 46.4 0.2 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02267.1 - 8.4e-10 38.8 0.1 0.00086 19.3 0.1 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EFX02267.1 - 0.026 14.0 0.1 0.052 13.0 0.1 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Hydrolase_6 PF13344.6 EFX02268.1 - 3.4e-19 68.8 0.0 7.6e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX02268.1 - 7e-17 61.3 0.1 5.2e-16 58.5 0.0 2.5 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EFX02268.1 - 5.1e-05 23.7 0.1 0.91 9.8 0.0 4.0 3 1 1 4 4 4 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFX02268.1 - 0.086 13.2 0.1 2.7 8.4 0.0 2.8 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Translin PF01997.16 EFX02269.1 - 2.4e-56 191.0 0.0 2.8e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 Translin family TNT PF14021.6 EFX02270.1 - 6.4e-33 113.2 0.2 1.7e-32 111.8 0.0 1.7 2 0 0 2 2 2 1 Tuberculosis necrotizing toxin Peptidase_C65 PF10275.9 EFX02271.1 - 1.9e-44 152.0 0.0 1.9e-44 152.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase C65 Otubain SurE PF01975.17 EFX02272.1 - 4.6e-35 121.2 0.0 8.8e-35 120.3 0.0 1.4 1 0 0 1 1 1 1 Survival protein SurE Transp_cyt_pur PF02133.15 EFX02273.1 - 1.8e-92 310.4 34.7 2.1e-92 310.2 34.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2443 PF10398.9 EFX02273.1 - 0.2 11.7 0.0 0.41 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) PQ-loop PF04193.14 EFX02274.1 - 2.1e-39 133.1 8.5 1.1e-19 69.9 0.2 2.8 2 1 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EFX02274.1 - 0.0056 17.5 0.1 0.4 11.5 0.1 2.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor BAR PF03114.18 EFX02275.1 - 2.8e-54 184.3 2.0 3.6e-54 183.9 2.0 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 EFX02275.1 - 3.3e-06 26.4 2.2 4.9e-06 25.9 2.2 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF3086 PF11285.8 EFX02275.1 - 0.0062 15.7 0.3 0.0098 15.0 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3086) HAUS6_N PF14661.6 EFX02275.1 - 0.22 11.0 3.8 0.25 10.9 2.5 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Trypan_PARP PF05887.11 EFX02275.1 - 1.2 9.2 12.1 0.23 11.4 2.6 2.3 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) GBP_C PF02841.14 EFX02275.1 - 1.3 8.4 10.2 0.1 12.0 5.6 1.4 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain OmpH PF03938.14 EFX02275.1 - 2.1 8.7 8.4 0.59 10.5 5.3 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Arteri_GP4 PF02497.15 EFX02276.1 - 0.11 12.7 0.0 0.41 10.8 0.0 1.9 2 0 0 2 2 2 0 Arterivirus glycoprotein DUF2721 PF11026.8 EFX02276.1 - 0.11 12.4 2.9 0.28 11.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Aldo_ket_red PF00248.21 EFX02277.1 - 6.9e-46 156.8 0.0 8e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family mRNA_triPase PF02940.15 EFX02278.1 - 9e-58 195.6 0.2 1.4e-57 195.0 0.2 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain eIF-3_zeta PF05091.12 EFX02278.1 - 1.4 7.8 8.0 2.4 7.0 8.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) dCMP_cyt_deam_1 PF00383.23 EFX02279.1 - 2.6e-11 43.3 0.1 3.8e-11 42.8 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFX02279.1 - 7e-09 35.6 0.0 8.8e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 EFX02279.1 - 0.00053 19.9 0.1 0.00069 19.6 0.1 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 EFX02279.1 - 0.0011 19.1 0.8 0.0019 18.3 0.8 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 EFX02279.1 - 0.0052 16.9 0.3 0.0069 16.4 0.3 1.2 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 EFX02279.1 - 0.0065 16.6 0.3 0.0088 16.2 0.3 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 NAD2 PF18782.1 EFX02279.1 - 0.01 16.0 0.4 0.016 15.3 0.4 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 XOO_2897-deam PF14440.6 EFX02279.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Bd3614-deam PF14439.6 EFX02279.1 - 0.022 14.8 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase APOBEC3 PF18771.1 EFX02279.1 - 0.029 14.5 0.1 0.048 13.8 0.1 1.3 1 0 0 1 1 1 0 APOBEC3 Fungal_trans PF04082.18 EFX02280.1 - 3.9e-10 39.2 0.0 6.1e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02280.1 - 1.2e-07 31.7 10.0 2.1e-07 30.9 10.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NRIP1_repr_3 PF15689.5 EFX02281.1 - 0.14 12.5 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 3 Paf67 PF10255.9 EFX02282.1 - 9e-157 522.2 0.2 1.1e-156 522.0 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EFX02282.1 - 0.0092 16.0 0.0 0.046 13.8 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFX02282.1 - 0.024 14.5 0.0 0.098 12.5 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TSKS PF15358.6 EFX02282.1 - 0.23 9.8 0.0 0.37 9.1 0.0 1.2 1 0 0 1 1 1 0 Testis-specific serine kinase substrate Defensin_int PF17858.1 EFX02283.1 - 0.091 12.8 2.5 0.18 11.8 2.5 1.5 1 0 0 1 1 1 0 Platypus intermediate defensin-like peptide NmrA PF05368.13 EFX02284.1 - 2.2e-25 89.6 0.0 2.9e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX02284.1 - 1.2e-07 31.8 1.8 6.5e-07 29.4 1.8 2.1 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFX02284.1 - 0.00042 19.4 0.9 0.0006 18.9 0.9 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EFX02284.1 - 0.00051 20.3 1.6 0.00054 20.2 0.3 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFX02284.1 - 0.00068 19.2 1.5 0.00089 18.8 0.2 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFX02284.1 - 0.0014 19.1 0.0 0.0037 17.7 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 EFX02284.1 - 0.0015 19.2 0.1 0.0046 17.7 0.0 1.8 2 0 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase KR PF08659.10 EFX02284.1 - 0.0037 17.2 0.1 0.0089 16.0 0.1 1.6 1 0 0 1 1 1 1 KR domain PLU-1 PF08429.11 EFX02285.1 - 5.3e-109 364.5 5.2 5.4e-106 354.6 5.4 2.4 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EFX02285.1 - 2.9e-43 146.9 0.2 5.9e-43 145.9 0.2 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 EFX02285.1 - 1.6e-19 70.3 0.1 4.9e-19 68.8 0.1 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 EFX02285.1 - 9.8e-16 57.4 0.7 2.9e-15 55.9 0.7 1.9 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 EFX02285.1 - 2e-13 50.5 6.8 4.6e-13 49.3 6.8 1.7 1 0 0 1 1 1 1 C5HC2 zinc finger PHD PF00628.29 EFX02285.1 - 6.7e-08 32.3 16.0 1.4e-07 31.3 9.3 2.9 2 0 0 2 2 2 1 PHD-finger TMF_TATA_bd PF12325.8 EFX02285.1 - 0.082 13.1 0.6 2.5 8.4 0.2 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding MannoseP_isomer PF01050.18 EFX02285.1 - 0.094 12.6 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase PHD_4 PF16866.5 EFX02285.1 - 8.7 6.5 12.4 0.24 11.5 5.3 2.1 2 0 0 2 2 2 0 PHD-finger Ribosomal_S7e PF01251.18 EFX02287.1 - 1.4e-80 269.4 0.0 1.7e-80 269.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e MFS_1 PF07690.16 EFX02288.1 - 7.8e-32 110.6 29.6 7.8e-32 110.6 29.6 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Ribosomal_L34e PF01199.18 EFX02290.1 - 1.5e-43 147.0 2.5 2.2e-43 146.5 2.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e Vint PF14623.6 EFX02291.1 - 1.1e-55 187.9 0.0 1.9e-55 187.2 0.0 1.3 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EFX02291.1 - 3.2e-24 84.9 0.2 5.7e-24 84.0 0.2 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA_2 PF13519.6 EFX02291.1 - 9.2e-13 48.8 0.0 1.8e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFX02291.1 - 1.1e-11 45.3 0.0 2.1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFX02291.1 - 1.1e-06 28.7 0.0 1.8e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain Hint PF01079.20 EFX02291.1 - 0.095 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Hint module Acetyltransf_1 PF00583.25 EFX02292.1 - 9.5e-05 22.6 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX02292.1 - 0.02 15.3 0.0 0.029 14.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Vps4_C PF09336.10 EFX02292.1 - 0.14 12.1 0.1 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain ABA_GPCR PF12430.8 EFX02294.1 - 3.3e-57 193.2 0.0 8.1e-57 191.9 0.0 1.7 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 EFX02294.1 - 2.4e-23 82.0 0.2 7e-23 80.5 0.0 1.9 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal AdoHcyase PF05221.17 EFX02295.1 - 3.5e-129 430.2 0.0 3.8e-125 417.0 0.0 2.1 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EFX02295.1 - 2e-82 275.0 1.7 3e-82 274.5 1.7 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFX02295.1 - 2.7e-05 23.6 0.1 5.5e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFX02295.1 - 0.0036 16.9 0.2 0.0067 16.0 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 EFX02295.1 - 0.042 13.6 0.1 0.079 12.7 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase EAP30 PF04157.16 EFX02296.1 - 3.4e-75 252.4 0.1 3.8e-75 252.2 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Oxidored_molyb PF00174.19 EFX02297.1 - 2.7e-54 183.4 0.0 3.7e-54 182.9 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EFX02297.1 - 6.1e-27 94.3 0.2 1.5e-26 93.1 0.2 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 EFX02297.1 - 3.1e-08 33.7 0.0 5.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sel1 PF08238.12 EFX02298.1 - 7.4e-43 144.0 25.1 7.6e-08 32.8 0.0 7.7 7 0 0 7 7 7 7 Sel1 repeat ATP12 PF07542.11 EFX02298.1 - 1.3e-31 109.4 0.1 2.1e-31 108.7 0.1 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein WES_acyltransf PF03007.16 EFX02299.1 - 0.049 13.4 0.5 0.096 12.4 0.5 1.4 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1833 PF08875.11 EFX02299.1 - 0.32 10.5 2.1 0.55 9.8 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1833) PCI PF01399.27 EFX02300.1 - 1.6e-16 60.7 0.0 3.9e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 PCI domain TPR_11 PF13414.6 EFX02300.1 - 0.0025 17.4 1.3 0.0093 15.6 0.3 2.5 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.28 EFX02300.1 - 0.018 14.8 0.9 0.11 12.3 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02300.1 - 0.019 15.0 1.1 1.1 9.4 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF3116 PF11313.8 EFX02300.1 - 0.052 13.4 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3116) TPR_12 PF13424.6 EFX02300.1 - 0.06 13.6 2.7 4 7.8 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02300.1 - 0.079 13.1 2.8 0.2 11.9 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02300.1 - 1.1 9.7 3.2 0.93 9.9 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFX02300.1 - 7.2 7.7 6.2 17 6.6 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat MFS_1 PF07690.16 EFX02301.1 - 1.4e-48 165.6 26.3 2.8e-47 161.4 23.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02301.1 - 1.6e-11 43.7 6.2 1.6e-11 43.7 6.2 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 EFX02301.1 - 0.003 16.0 5.0 0.003 16.0 5.0 1.5 2 0 0 2 2 2 1 Transmembrane secretion effector AgrB PF04647.15 EFX02301.1 - 0.0072 15.7 0.0 0.022 14.1 0.0 1.8 1 0 0 1 1 1 1 Accessory gene regulator B MFS_1_like PF12832.7 EFX02301.1 - 0.85 8.4 8.5 0.28 10.0 3.1 2.3 2 1 0 2 2 2 0 MFS_1 like family Peptidase_S8 PF00082.22 EFX02302.1 - 2.9e-29 102.3 20.7 7.2e-29 101.0 20.6 1.8 1 1 0 1 1 1 1 Subtilase family Zn_clus PF00172.18 EFX02303.1 - 0.00046 20.3 8.4 0.0054 16.8 8.4 2.3 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Yippee-Mis18 PF03226.14 EFX02304.1 - 1.6e-17 63.6 0.0 2.7e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EFX02304.1 - 0.19 12.0 0.1 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 C-terminal domain of RIG-I Helo_like_N PF17111.5 EFX02305.1 - 0.17 11.2 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins CWC25 PF12542.8 EFX02306.1 - 2.2e-26 92.7 0.0 2.2e-26 92.7 0.0 3.9 3 1 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 EFX02306.1 - 3.7e-09 36.6 16.9 3.7e-09 36.6 16.9 3.5 2 1 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR UCH PF00443.29 EFX02307.1 - 1.2e-20 74.1 0.0 2.7e-20 72.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX02307.1 - 4e-11 43.1 0.2 2.4e-10 40.5 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pap_E4 PF02711.14 EFX02308.1 - 0.0078 17.2 1.6 0.02 15.8 1.6 1.7 1 0 0 1 1 1 1 E4 protein Na_Ca_ex PF01699.24 EFX02310.1 - 7.9e-26 90.8 32.3 5.9e-16 58.8 12.8 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3923 PF13061.6 EFX02310.1 - 1 9.5 3.9 1.7 8.8 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3923) RICTOR_N PF14664.6 EFX02311.1 - 1.9e-132 441.8 3.9 3.1e-132 441.1 3.9 1.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term Phos_pyr_kin PF08543.12 EFX02311.1 - 1.2e-49 168.9 0.4 1.2e-23 83.7 0.0 2.4 1 1 1 2 2 2 2 Phosphomethylpyrimidine kinase RICTOR_M PF14666.6 EFX02311.1 - 1.2e-36 124.7 0.2 2.9e-35 120.2 0.0 3.1 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EFX02311.1 - 3.3e-28 97.7 0.3 4.7e-27 94.0 0.2 3.0 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 EFX02311.1 - 2.4e-16 60.1 0.4 4.2e-07 30.3 0.1 4.3 3 1 1 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain HR1 PF02185.16 EFX02311.1 - 3.6e-14 52.6 8.1 3.6e-14 52.6 8.1 2.0 2 0 0 2 2 2 1 Hr1 repeat TENA_THI-4 PF03070.16 EFX02311.1 - 8.8e-11 42.0 0.1 2.3e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 TENA/THI-4/PQQC family DUF724 PF05266.14 EFX02311.1 - 3.4 7.5 5.8 7.6 6.3 3.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF3336 PF11815.8 EFX02312.1 - 4.8e-29 100.8 0.1 1e-28 99.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EFX02312.1 - 2.7e-26 93.0 0.0 9.7e-26 91.2 0.0 2.0 2 0 0 2 2 2 1 Patatin-like phospholipase NOA36 PF06524.12 EFX02312.1 - 0.069 12.5 6.3 0.14 11.5 6.3 1.5 1 0 0 1 1 1 0 NOA36 protein Glycos_transf_1 PF00534.20 EFX02313.1 - 1.2e-32 112.8 0.0 1.8e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFX02313.1 - 4.8e-26 91.8 0.7 1e-25 90.7 0.7 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFX02313.1 - 4.3e-15 56.5 2.2 4.3e-15 56.5 2.2 2.9 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EFX02313.1 - 1.6e-14 54.3 1.9 4.3e-13 49.6 0.3 2.4 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EFX02313.1 - 6e-10 39.4 0.0 1.8e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 FR47 PF08445.10 EFX02313.1 - 0.13 12.2 0.5 0.72 9.9 0.1 2.4 3 0 0 3 3 3 0 FR47-like protein GST_C_3 PF14497.6 EFX02315.1 - 1.7e-26 92.3 0.0 2.5e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFX02315.1 - 0.00034 20.9 0.0 1.3 9.4 0.0 2.6 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFX02315.1 - 0.0011 18.9 0.4 0.0023 17.9 0.4 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFX02315.1 - 0.0016 18.6 0.0 0.003 17.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFX02315.1 - 0.052 14.0 0.0 0.61 10.5 0.0 2.5 2 1 0 2 2 2 0 Glutathione S-transferase, N-terminal domain HLH PF00010.26 EFX02316.1 - 2.8e-12 46.4 0.4 6.6e-12 45.2 0.4 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MerR-DNA-bind PF09278.11 EFX02316.1 - 0.085 13.4 2.8 0.2 12.2 2.8 1.6 1 0 0 1 1 1 0 MerR, DNA binding RAP1 PF07218.11 EFX02316.1 - 0.49 8.6 6.8 0.53 8.5 6.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) IQCJ-SCHIP1 PF15157.6 EFX02316.1 - 2.1 8.2 5.5 4.9 7.0 5.5 1.6 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Cep57_MT_bd PF06657.13 EFX02316.1 - 2.3 8.7 10.0 0.53 10.8 1.6 2.9 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 PI3K_1B_p101 PF10486.9 EFX02316.1 - 3.5 5.3 13.2 7.9 4.1 13.2 1.4 1 1 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FAD_binding_3 PF01494.19 EFX02317.1 - 3.9e-09 36.2 0.9 3e-08 33.3 0.9 2.3 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EFX02317.1 - 0.00088 18.7 0.0 0.15 11.3 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EFX02317.1 - 0.01 15.1 1.6 0.02 14.1 0.5 2.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX02317.1 - 0.015 15.5 0.1 0.039 14.2 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SesA PF17107.5 EFX02318.1 - 1.5e-36 125.2 0.2 2.9e-36 124.3 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases O-FucT PF10250.9 EFX02318.1 - 0.19 11.4 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Glyco_hydro_16 PF00722.21 EFX02319.1 - 1.4e-16 60.5 0.9 6.2e-16 58.4 0.9 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EFX02319.1 - 2.5e-08 32.8 3.5 3.4e-05 22.5 0.5 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) NlpE PF04170.12 EFX02319.1 - 0.12 13.4 0.1 4.9 8.2 0.0 2.2 2 0 0 2 2 2 0 NlpE N-terminal domain peroxidase PF00141.23 EFX02320.1 - 1.1e-28 100.4 0.2 2.2e-28 99.5 0.0 1.5 2 0 0 2 2 2 1 Peroxidase Glyco_tranf_2_3 PF13641.6 EFX02320.1 - 1.4e-19 70.9 0.3 2.4e-19 70.1 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFX02320.1 - 0.021 14.6 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 FAD_binding_3 PF01494.19 EFX02321.1 - 6.9e-22 78.2 0.0 1.4e-21 77.1 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX02321.1 - 6e-11 42.5 8.4 1.2e-05 25.1 5.3 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX02321.1 - 3.1e-10 39.8 0.2 6.6e-05 22.3 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX02321.1 - 1.2e-08 34.3 1.2 0.014 14.2 0.0 3.1 3 0 0 3 3 3 3 Tryptophan halogenase NAD_binding_8 PF13450.6 EFX02321.1 - 1.3e-08 34.9 0.9 5e-08 33.0 0.9 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFX02321.1 - 4e-06 25.8 1.6 0.0016 17.2 0.9 2.1 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.12 EFX02321.1 - 5.6e-06 25.6 2.1 0.013 14.6 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 EFX02321.1 - 6e-06 25.6 5.1 1.5e-05 24.3 5.1 1.7 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFX02321.1 - 1.1e-05 25.9 0.1 0.0014 19.1 0.3 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX02321.1 - 0.00012 21.6 4.9 0.00019 20.9 4.9 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EFX02321.1 - 0.00055 19.3 4.1 0.1 11.8 0.9 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EFX02321.1 - 0.0012 18.8 3.2 0.01 15.8 3.2 2.2 1 1 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 EFX02321.1 - 0.0015 17.8 0.9 0.0042 16.4 0.8 1.7 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 EFX02321.1 - 0.011 14.8 4.0 0.043 12.9 4.4 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A MCRA PF06100.11 EFX02321.1 - 0.062 12.1 0.2 0.22 10.2 0.1 1.7 2 0 0 2 2 2 0 MCRA family UDPG_MGDP_dh_N PF03721.14 EFX02321.1 - 0.066 12.8 0.2 0.099 12.2 0.2 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rossmann-like PF10727.9 EFX02321.1 - 0.068 13.0 1.5 0.12 12.3 0.3 2.0 2 0 0 2 2 2 0 Rossmann-like domain Pyr_redox_3 PF13738.6 EFX02321.1 - 0.07 12.4 2.8 0.2 10.9 2.8 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EFX02321.1 - 0.08 12.2 0.7 0.16 11.3 0.7 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF1188 PF06690.11 EFX02321.1 - 0.19 11.2 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) SE PF08491.10 EFX02321.1 - 0.23 10.5 0.0 0.35 9.9 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase 3HCDH_N PF02737.18 EFX02321.1 - 0.27 11.1 2.0 0.48 10.3 2.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Uricase PF01014.18 EFX02322.1 - 7.3e-78 259.2 2.2 2.2e-40 137.9 0.4 2.0 2 0 0 2 2 2 2 Uricase Hexapep PF00132.24 EFX02324.1 - 9.7e-08 31.5 9.4 3.4e-05 23.4 1.5 4.2 3 1 2 5 5 5 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFX02324.1 - 0.0015 18.2 4.4 0.75 9.6 0.1 3.7 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase AMP-binding PF00501.28 EFX02325.1 - 4.7e-89 298.9 0.1 6.7e-89 298.4 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX02325.1 - 7.2e-17 62.1 0.2 4.2e-16 59.7 0.0 2.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Peptidase_M78 PF06114.13 EFX02325.1 - 0.13 12.2 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain HEAT PF02985.22 EFX02326.1 - 0.048 13.9 2.2 0.2 12.0 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.6 EFX02326.1 - 0.063 13.8 0.5 1.3 9.6 0.0 3.2 3 0 0 3 3 3 0 HEAT-like repeat Arm PF00514.23 EFX02326.1 - 0.36 11.0 3.2 0.73 10.0 0.1 3.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Acetyltransf_1 PF00583.25 EFX02327.1 - 3e-18 66.1 0.0 3.8e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX02327.1 - 2.5e-09 37.4 0.0 4.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX02327.1 - 4.5e-08 33.0 0.0 7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EFX02327.1 - 8.9e-08 32.1 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFX02327.1 - 0.00025 21.7 0.0 0.00034 21.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFX02327.1 - 0.0038 17.4 0.0 0.006 16.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 EFX02327.1 - 0.076 12.7 0.0 0.2 11.4 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ RNR_inhib PF08591.10 EFX02328.1 - 1.5e-23 84.1 0.1 1.7e-22 80.8 0.0 2.6 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor SIP1 PF04938.12 EFX02328.1 - 2.2e-07 30.8 0.0 0.0025 17.5 0.0 2.6 3 0 0 3 3 3 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) Peptidase_M16_C PF05193.21 EFX02329.1 - 2.5e-60 203.6 0.0 3.5e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFX02329.1 - 1.5e-43 148.3 0.0 3.3e-43 147.2 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) PEPcase PF00311.17 EFX02330.1 - 0.033 12.3 0.1 0.037 12.1 0.1 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase DUF2732 PF10809.8 EFX02332.1 - 0.0096 15.8 0.6 0.019 14.8 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2732) Sgf11 PF08209.11 EFX02332.1 - 0.038 13.5 3.5 0.084 12.4 3.5 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) zf_UBZ PF18439.1 EFX02332.1 - 0.26 10.9 2.2 2.2 7.9 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Apt1 PF10351.9 EFX02332.1 - 1.1 8.0 4.9 4.6 6.0 0.0 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Glyco_hydro_18 PF00704.28 EFX02333.1 - 2.4e-27 96.5 2.2 2.6e-26 93.1 2.2 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_1 PF00734.18 EFX02333.1 - 3.6e-09 36.4 14.2 1.6e-08 34.3 14.2 2.3 1 0 0 1 1 1 1 Fungal cellulose binding domain SWI-SNF_Ssr4 PF08549.10 EFX02333.1 - 5.6 5.5 5.0 8.6 4.9 5.0 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Hexokinase_2 PF03727.16 EFX02334.1 - 2e-76 256.6 0.0 2.9e-76 256.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EFX02334.1 - 8e-74 247.9 0.0 1.4e-73 247.1 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Ribosomal_S11 PF00411.19 EFX02334.1 - 0.021 15.2 0.5 0.068 13.6 0.5 1.8 1 0 0 1 1 1 0 Ribosomal protein S11 HHH_5 PF14520.6 EFX02334.1 - 0.057 14.0 0.0 0.18 12.4 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain ATP_bind_1 PF03029.17 EFX02335.1 - 1.6e-70 237.6 0.0 2.3e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CTP_transf_like PF01467.26 EFX02335.1 - 8.9e-09 35.7 0.0 0.006 16.8 0.0 2.6 1 1 1 2 2 2 2 Cytidylyltransferase-like AAA_24 PF13479.6 EFX02335.1 - 4.4e-05 23.3 0.0 7.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EFX02335.1 - 0.0025 17.4 0.0 0.027 14.0 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFX02335.1 - 0.0032 16.5 0.0 0.19 10.7 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 EFX02335.1 - 0.0046 16.2 0.0 0.069 12.3 0.0 2.2 2 0 0 2 2 2 1 G-protein alpha subunit AAA_22 PF13401.6 EFX02335.1 - 0.0057 16.9 0.0 0.027 14.7 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 EFX02335.1 - 0.0081 16.6 0.0 0.023 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EFX02335.1 - 0.025 14.7 0.0 0.35 10.9 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EFX02335.1 - 0.027 13.8 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 EFX02335.1 - 0.029 14.5 0.0 0.071 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFX02335.1 - 0.03 13.9 0.0 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain LZ3wCH PF18517.1 EFX02335.1 - 0.031 14.4 0.0 0.13 12.4 0.0 2.0 1 0 0 1 1 1 0 Leucine zipper with capping helix domain NB-ARC PF00931.22 EFX02335.1 - 0.037 13.2 0.0 0.099 11.8 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 EFX02335.1 - 0.039 13.7 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFX02335.1 - 0.082 12.5 0.0 0.38 10.3 0.0 2.0 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 EFX02335.1 - 0.14 11.6 0.0 3.9 6.9 0.0 2.7 3 0 0 3 3 3 0 ADP-ribosylation factor family CLP1_P PF16575.5 EFX02335.1 - 0.14 11.9 0.0 2.9 7.6 0.0 2.7 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF4455 PF14643.6 EFX02335.1 - 0.19 10.3 0.8 0.3 9.7 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) Promethin PF16015.5 EFX02337.1 - 2.5e-14 53.1 18.0 3.2e-14 52.7 18.0 1.2 1 0 0 1 1 1 1 Promethin AA_kinase PF00696.28 EFX02338.1 - 2.3e-28 99.4 0.0 3.3e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family NAT PF04768.13 EFX02338.1 - 7.8e-09 35.4 0.1 4.5e-08 32.9 0.0 2.2 3 0 0 3 3 3 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Raptor_N PF14538.6 EFX02339.1 - 6.4e-64 214.3 0.0 1.1e-63 213.6 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EFX02339.1 - 9.4e-07 29.4 3.6 12 6.9 0.1 6.2 5 1 0 5 5 5 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 EFX02339.1 - 0.0017 18.4 0.0 0.96 9.5 0.0 2.6 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Atx10homo_assoc PF09759.9 EFX02339.1 - 0.018 15.0 0.1 0.035 14.1 0.1 1.4 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Glyco_hydro_3_C PF01915.22 EFX02340.1 - 7.3e-45 153.4 0.0 1.1e-44 152.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX02340.1 - 3.9e-35 121.8 0.0 6.9e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX02340.1 - 1.7e-14 53.6 0.0 3e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Sgf11_N PF18519.1 EFX02340.1 - 0.12 11.9 0.9 0.33 10.5 0.6 1.9 2 0 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain Abhydrolase_3 PF07859.13 EFX02341.1 - 2.8e-26 92.7 0.0 4.9e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFX02341.1 - 1.6e-06 27.3 0.1 4.8e-06 25.7 0.0 1.7 2 0 0 2 2 2 1 Carboxylesterase family AXE1 PF05448.12 EFX02341.1 - 0.0021 16.8 0.0 0.0036 16.0 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 EFX02341.1 - 0.0027 18.3 1.9 0.0027 18.3 1.9 2.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFX02341.1 - 0.014 14.8 0.0 0.033 13.7 0.0 1.5 2 0 0 2 2 2 0 Prolyl oligopeptidase family P5CR_dimer PF14748.6 EFX02342.1 - 3.2e-35 120.5 1.1 3.2e-35 120.5 1.1 1.9 2 1 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EFX02342.1 - 1.6e-15 57.4 0.5 3.6e-15 56.3 0.5 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFX02342.1 - 0.044 13.9 0.1 0.087 13.0 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase PDH PF02153.17 EFX02343.1 - 8e-12 44.7 0.0 1.1e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase His_biosynth PF00977.21 EFX02344.1 - 2e-46 158.3 0.3 8.8e-46 156.2 0.3 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EFX02344.1 - 2.8e-20 72.9 0.0 4.3e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EFX02344.1 - 4.4e-07 29.9 0.0 9.3e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EFX02344.1 - 2.4e-06 27.3 0.0 4.2e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Dus PF01207.17 EFX02344.1 - 0.0082 15.3 0.0 0.018 14.2 0.0 1.5 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Peptidase_C26 PF07722.13 EFX02344.1 - 0.047 13.4 0.2 0.65 9.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 SICA_beta PF12878.7 EFX02345.1 - 0.059 13.5 0.0 0.072 13.3 0.0 1.0 1 0 0 1 1 1 0 SICA extracellular beta domain Protoglobin PF11563.8 EFX02346.1 - 1.2e-57 194.2 0.0 1.5e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 Protoglobin Glyco_hydro_cc PF11790.8 EFX02347.1 - 7.2e-66 222.2 1.1 9.1e-65 218.6 1.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_39 PF01229.17 EFX02347.1 - 0.052 12.1 0.0 0.069 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 Bac_luciferase PF00296.20 EFX02348.1 - 3.6e-54 184.3 0.3 3.6e-54 184.3 0.3 1.6 2 0 0 2 2 2 1 Luciferase-like monooxygenase GFA PF04828.14 EFX02349.1 - 2.1e-11 44.0 0.4 3.1e-11 43.5 0.4 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme RRM_1 PF00076.22 EFX02351.1 - 7.5e-19 67.3 0.0 2.6e-12 46.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIIC_sub6 PF10419.9 EFX02352.1 - 1.3e-23 82.6 0.0 2.4e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain BTB PF00651.31 EFX02354.1 - 7.9e-08 32.5 0.0 2.2e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain ketoacyl-synt PF00109.26 EFX02355.1 - 1.2e-74 251.1 0.0 2.9e-74 249.8 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EFX02355.1 - 6e-55 185.9 4.1 7e-54 182.5 1.3 3.1 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFX02355.1 - 6.1e-55 186.6 0.6 1.8e-54 185.0 0.6 1.9 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFX02355.1 - 6.4e-52 177.0 2.3 1.6e-51 175.7 2.3 1.7 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFX02355.1 - 4.3e-36 123.5 0.3 1.4e-35 121.8 0.3 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 EFX02355.1 - 3.4e-18 67.0 0.1 4.9e-17 63.2 0.1 2.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 EFX02355.1 - 2.5e-15 57.0 0.0 7.4e-15 55.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EFX02355.1 - 4.6e-14 52.5 2.4 1.1e-13 51.3 0.1 2.9 3 0 0 3 3 3 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EFX02355.1 - 3.3e-13 50.1 0.2 5.8e-10 39.6 0.0 2.6 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EFX02355.1 - 1.4e-11 44.2 7.3 2.3e-09 37.0 0.1 3.2 3 0 0 3 3 3 2 short chain dehydrogenase Methyltransf_23 PF13489.6 EFX02355.1 - 2.2e-11 43.9 0.0 4.8e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02355.1 - 8e-11 42.5 0.0 3.8e-10 40.4 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EFX02355.1 - 2.1e-09 37.6 0.1 7.6e-09 35.8 0.1 2.0 2 0 0 2 2 1 1 Phosphopantetheine attachment site Methyltransf_11 PF08241.12 EFX02355.1 - 8.3e-09 36.0 0.0 3e-08 34.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EFX02355.1 - 2.7e-07 30.4 8.7 7.1e-07 29.0 0.2 3.5 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 EFX02355.1 - 2.4e-06 27.4 0.0 9.1e-06 25.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 EFX02355.1 - 2.6e-05 23.7 1.0 6.2e-05 22.5 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain ADH_N PF08240.12 EFX02355.1 - 0.00033 20.5 0.1 0.00097 19.0 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.18 EFX02355.1 - 0.027 13.8 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family ACP_syn_III PF08545.10 EFX02355.1 - 0.093 12.6 2.2 0.39 10.6 2.2 2.2 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 EFX02355.1 - 0.78 9.9 3.4 1.2 9.4 0.2 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Ribosomal_S30 PF04758.14 EFX02356.1 - 7.1e-28 96.6 6.6 7.6e-28 96.5 6.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Ferritin_2 PF13668.6 EFX02357.1 - 2e-06 28.0 0.0 4.2e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Ferritin-like domain EF-hand_4 PF12763.7 EFX02359.1 - 1.6e-05 24.8 0.0 3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EFX02359.1 - 0.0012 18.2 0.0 0.0025 17.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EFX02359.1 - 0.064 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 EFX02359.1 - 0.096 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EFX02359.1 - 0.19 11.7 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Pkinase PF00069.25 EFX02360.1 - 1.6e-56 191.6 0.0 4.8e-53 180.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02360.1 - 8.6e-33 113.7 0.0 1.5e-30 106.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFX02360.1 - 0.00049 19.5 0.0 0.00073 18.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFX02360.1 - 0.0019 17.2 0.0 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFX02360.1 - 0.0026 16.8 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EFX02360.1 - 0.035 12.9 0.0 0.058 12.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SNF2_N PF00176.23 EFX02361.1 - 4.1e-07 29.0 0.0 2.8e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX02361.1 - 0.00015 22.1 0.0 0.0012 19.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AMP-binding PF00501.28 EFX02362.1 - 1.6e-67 228.0 0.0 1.9e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX02362.1 - 1.4e-06 29.2 0.1 2.6e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Gln-synt_C PF00120.24 EFX02363.1 - 3.7e-17 62.3 0.0 4.8e-13 48.8 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EFX02363.1 - 3.3e-14 52.4 0.0 5.9e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF3449 PF11931.8 EFX02364.1 - 1.1e-75 253.4 0.4 2.3e-75 252.5 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EFX02364.1 - 1.5e-25 89.5 0.2 2.8e-25 88.6 0.2 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-C2H2_jaz PF12171.8 EFX02364.1 - 2.1e-06 27.8 7.0 2.4e-06 27.7 0.2 2.6 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX02364.1 - 5.4e-06 26.6 7.2 1.1e-05 25.6 0.3 2.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFX02364.1 - 0.0071 16.7 3.6 0.13 12.6 0.1 3.3 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 EFX02364.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger SF3a60_bindingd PF12108.8 EFX02364.1 - 0.14 12.1 0.1 0.4 10.6 0.1 1.8 1 1 0 1 1 1 0 Splicing factor SF3a60 binding domain PRP9_N PF16958.5 EFX02364.1 - 2.5 8.1 11.3 0.18 11.9 1.2 2.7 2 1 1 3 3 3 0 Pre-mRNA-splicing factor PRP9 N-terminus Cupin_2 PF07883.11 EFX02365.1 - 1.5e-21 75.8 1.6 3.6e-14 52.2 0.2 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EFX02365.1 - 0.0019 17.8 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) CENP-C_C PF11699.8 EFX02365.1 - 0.029 14.6 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 Mif2/CENP-C like Cupin_1 PF00190.22 EFX02365.1 - 0.1 12.2 0.0 0.76 9.4 0.0 2.1 2 0 0 2 2 2 0 Cupin AraC_binding PF02311.19 EFX02365.1 - 0.11 12.4 0.6 6.5 6.7 0.1 2.5 2 0 0 2 2 2 0 AraC-like ligand binding domain PhoLip_ATPase_C PF16212.5 EFX02366.1 - 6.1e-68 229.3 17.0 1.1e-67 228.4 17.0 1.4 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFX02366.1 - 4.6e-22 77.5 1.6 7.8e-22 76.7 0.0 2.2 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFX02366.1 - 3e-13 50.6 0.2 6.9e-06 26.5 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFX02366.1 - 2.9e-10 40.1 0.0 2.6e-09 37.0 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFX02366.1 - 2e-06 27.5 0.0 5.1e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Fungal_trans PF04082.18 EFX02366.1 - 1.8e-05 23.9 0.0 3.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hydrolase_3 PF08282.12 EFX02366.1 - 0.0042 16.9 0.0 0.0085 15.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1688 PF07958.11 EFX02367.1 - 5.8e-177 588.6 0.0 7.3e-177 588.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) DUF1639 PF07797.14 EFX02369.1 - 9 6.4 6.0 18 5.4 5.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) Sugar_tr PF00083.24 EFX02370.1 - 1.5e-81 274.6 24.5 1.8e-81 274.3 24.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX02370.1 - 7.3e-27 94.2 51.5 5e-24 84.9 25.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFX02370.1 - 0.61 8.3 12.0 0.042 12.1 1.1 3.0 2 2 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Arginosuc_synth PF00764.19 EFX02371.1 - 3.8e-150 500.5 0.0 4.4e-150 500.3 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EFX02371.1 - 0.0037 16.8 0.0 0.0064 16.0 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EFX02371.1 - 0.038 12.8 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase AAA_11 PF13086.6 EFX02372.1 - 5.8e-14 52.5 0.0 1e-13 51.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EFX02372.1 - 1e-13 51.4 0.0 1.8e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX02372.1 - 0.047 14.0 0.1 1.6 9.1 0.0 3.1 2 1 0 2 2 2 0 AAA domain Complex1_LYR PF05347.15 EFX02373.1 - 8e-07 29.0 0.7 1.5e-06 28.1 0.7 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFX02373.1 - 0.0033 18.1 1.2 0.0063 17.2 1.2 1.6 1 1 0 1 1 1 1 Complex1_LYR-like KKLCAg1 PF15204.6 EFX02373.1 - 0.18 11.9 0.0 0.29 11.3 0.0 1.2 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 Gtr1_RagA PF04670.12 EFX02374.1 - 1.6e-92 309.0 0.1 3.7e-92 307.9 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFX02374.1 - 1e-08 35.4 1.1 1.4e-08 34.9 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX02374.1 - 1.1e-08 34.7 0.0 1.8e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX02374.1 - 1.8e-08 34.5 0.0 3.7e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EFX02374.1 - 7.1e-08 32.2 0.1 1.3e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 Ras family SUIM_assoc PF16619.5 EFX02374.1 - 4.8e-05 23.3 2.1 0.00014 21.9 1.6 2.1 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 RsgA_GTPase PF03193.16 EFX02374.1 - 0.0013 18.6 0.8 0.71 9.8 0.1 3.1 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 EFX02374.1 - 0.0041 16.8 0.5 0.049 13.4 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain SRPRB PF09439.10 EFX02374.1 - 0.011 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFX02374.1 - 0.022 13.9 3.6 1.9 7.6 0.6 2.5 2 1 1 3 3 3 0 G-protein alpha subunit ABC_tran PF00005.27 EFX02374.1 - 0.049 14.2 0.1 0.049 14.2 0.1 2.1 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EFX02374.1 - 0.059 12.5 1.6 0.063 12.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFX02374.1 - 0.077 12.5 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Spt20 PF12090.8 EFX02374.1 - 8.2 6.0 15.0 13 5.3 15.0 1.2 1 0 0 1 1 1 0 Spt20 family FixQ PF05545.11 EFX02375.1 - 0.039 13.9 1.2 3.6 7.6 0.0 2.2 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ bVLRF1 PF18826.1 EFX02376.1 - 5.9e-63 211.2 0.1 1.4e-62 210.0 0.1 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EFX02376.1 - 0.00016 21.9 0.8 0.00039 20.7 0.8 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFX02376.1 - 0.066 13.7 0.9 0.21 12.1 0.9 1.9 1 0 0 1 1 1 0 Ankyrin repeat Nop52 PF05997.12 EFX02377.1 - 2.9e-43 148.2 0.0 1.2e-42 146.2 0.0 1.8 1 1 0 1 1 1 1 Nucleolar protein,Nop52 Transket_pyr PF02779.24 EFX02379.1 - 9.8e-64 214.3 0.0 2e-63 213.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EFX02379.1 - 9e-58 195.6 0.0 1.7e-57 194.7 0.0 1.4 2 0 0 2 2 2 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EFX02379.1 - 1.3e-57 193.7 0.2 2.3e-57 192.9 0.2 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EFX02379.1 - 3.7e-20 71.2 0.6 9.2e-20 70.0 0.6 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus DUF3824 PF12868.7 EFX02379.1 - 0.054 14.2 0.1 0.12 13.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Pullulanase_N2 PF17967.1 EFX02379.1 - 0.069 14.0 0.0 0.3 12.0 0.0 2.1 1 1 0 1 1 1 0 Pullulanase N2 domain RabGAP-TBC PF00566.18 EFX02380.1 - 2.2e-36 125.5 0.0 3.8e-19 69.2 0.0 3.6 3 0 0 3 3 3 3 Rab-GTPase-TBC domain GHMP_kinases_C PF08544.13 EFX02380.1 - 0.14 12.6 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal Rad9 PF04139.13 EFX02381.1 - 1.9e-09 37.4 0.0 2.3e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Rad9 fn2 PF00040.19 EFX02381.1 - 0.15 12.4 1.3 0.25 11.7 0.2 1.9 2 0 0 2 2 2 0 Fibronectin type II domain BSP_II PF05432.11 EFX02382.1 - 0.0067 16.2 0.2 0.0067 16.2 0.2 2.0 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) RNA_pol_inhib PF16857.5 EFX02382.1 - 0.013 15.3 0.0 0.039 13.7 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase inhibitor DUF755 PF05501.11 EFX02382.1 - 7.9 6.8 8.1 14 6.0 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) CwfJ_C_2 PF04676.14 EFX02383.1 - 5.2e-28 97.8 0.1 1.3e-27 96.5 0.1 1.7 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 EFX02383.1 - 9.8e-25 86.8 0.0 1.5e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 HSP70 PF00012.20 EFX02384.1 - 8.7e-06 24.2 0.2 0.00026 19.3 0.1 2.1 2 0 0 2 2 2 2 Hsp70 protein MFS_1 PF07690.16 EFX02385.1 - 1.9e-33 115.9 29.5 1.9e-33 115.9 29.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Lipase_3 PF01764.25 EFX02385.1 - 0.057 13.3 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 3) Zn_clus PF00172.18 EFX02386.1 - 7.2e-07 29.2 8.7 1.3e-06 28.4 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TruB_C_2 PF16198.5 EFX02386.1 - 0.05 13.8 0.1 0.28 11.4 0.0 2.3 2 0 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain UQ_con PF00179.26 EFX02387.1 - 1.3e-19 70.3 0.0 2.3e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EFX02387.1 - 0.063 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 UEV domain C1_4 PF07975.12 EFX02387.1 - 0.44 10.8 4.5 2.2 8.6 4.2 2.2 1 1 1 2 2 2 0 TFIIH C1-like domain Prominin PF05478.11 EFX02389.1 - 3.7e-05 21.9 2.8 3.7e-05 21.9 2.8 2.0 2 0 0 2 2 2 1 Prominin LemA PF04011.12 EFX02389.1 - 0.0018 18.1 3.4 0.057 13.3 1.6 2.8 1 1 1 2 2 2 1 LemA family FAM184 PF15665.5 EFX02389.1 - 0.16 11.8 24.7 0.0097 15.7 17.2 2.2 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B TACC_C PF05010.14 EFX02389.1 - 3.4 7.4 23.1 0.11 12.2 14.6 2.6 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ChAPs PF09295.10 EFX02390.1 - 1e-151 505.4 0.0 1.4e-151 505.0 0.0 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 EFX02390.1 - 0.00017 22.1 9.7 1.7 9.6 1.4 5.1 3 1 1 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02390.1 - 0.00036 20.4 3.4 0.32 11.2 2.2 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFX02390.1 - 0.00099 19.2 2.3 0.15 12.2 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02390.1 - 0.002 18.0 1.3 1.3 9.2 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFX02390.1 - 0.0045 17.5 5.8 1.4 9.5 0.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFX02390.1 - 0.0049 17.4 1.5 11 6.9 0.3 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02390.1 - 0.031 14.5 0.7 0.75 10.2 0.2 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02390.1 - 0.092 13.1 1.8 4.2 7.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFX02390.1 - 0.11 12.3 1.4 19 5.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat IFT57 PF10498.9 EFX02390.1 - 0.12 11.3 0.4 0.2 10.6 0.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1824 PF08854.10 EFX02390.1 - 0.13 12.2 0.1 2.5 8.1 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1824) Paf1 PF03985.13 EFX02390.1 - 0.76 8.7 3.7 1.3 7.9 3.7 1.3 1 0 0 1 1 1 0 Paf1 ANAPC3 PF12895.7 EFX02390.1 - 0.92 9.8 3.7 30 4.9 0.0 3.6 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 JAB PF01398.21 EFX02391.1 - 2.9e-09 36.9 0.1 2.4e-07 30.7 0.1 2.5 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF5597 PF18120.1 EFX02392.1 - 6.3e-30 104.0 0.0 9.9e-30 103.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5597) Glyco_hydro_42 PF02449.15 EFX02392.1 - 7.7e-11 41.9 0.0 1.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 EFX02392.1 - 6.1e-05 22.8 0.0 0.00047 19.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Zn_clus PF00172.18 EFX02393.1 - 1.4e-07 31.5 7.2 3.2e-07 30.4 7.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_3 PF13606.6 EFX02393.1 - 9.8e-06 25.6 0.0 0.016 15.7 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFX02393.1 - 1.5e-05 25.4 0.0 7.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX02393.1 - 0.0026 18.3 0.0 0.011 16.3 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Peptidase_S8 PF00082.22 EFX02393.1 - 0.083 12.1 2.6 0.15 11.3 2.6 1.3 1 0 0 1 1 1 0 Subtilase family Ank_5 PF13857.6 EFX02393.1 - 0.12 12.7 0.1 13 6.3 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) TAF6_C PF07571.13 EFX02394.1 - 3.6e-28 97.7 0.0 7.3e-28 96.7 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EFX02394.1 - 4.7e-20 71.5 0.0 9.1e-20 70.6 0.0 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFX02394.1 - 0.0099 16.1 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFX02394.1 - 0.039 14.3 0.0 0.06 13.7 0.0 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 GXWXG PF14231.6 EFX02395.1 - 9.1e-27 92.9 0.1 1.5e-26 92.2 0.1 1.4 1 0 0 1 1 1 1 GXWXG protein DUF4334 PF14232.6 EFX02395.1 - 7.2e-26 89.9 1.5 1.2e-25 89.2 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4334) B_solenoid_ydck PF18836.1 EFX02395.1 - 0.18 11.7 0.1 27 4.8 0.0 3.6 4 0 0 4 4 4 0 Beta solenoid repeat from YDCK XAP5 PF04921.14 EFX02397.1 - 1.3e-88 297.0 0.0 1.9e-88 296.5 0.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator SCHIP-1 PF10148.9 EFX02397.1 - 0.19 11.3 0.2 0.3 10.7 0.2 1.2 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 TPR_1 PF00515.28 EFX02398.1 - 2e-16 59.0 5.0 1.7e-08 33.9 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02398.1 - 2.5e-16 58.4 3.6 2e-06 27.5 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02398.1 - 6e-12 45.7 0.4 2.2e-07 31.1 0.1 3.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02398.1 - 5.2e-11 41.8 2.2 6.9e-06 25.9 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX02398.1 - 1.2e-08 35.0 0.1 0.085 13.5 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02398.1 - 1.3e-08 34.3 0.2 3.7e-06 26.6 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFX02398.1 - 1.3e-08 34.4 0.5 1.2e-05 24.9 0.1 3.8 1 1 2 3 3 3 1 TPR repeat TPR_9 PF13371.6 EFX02398.1 - 2.3e-05 24.5 0.1 0.15 12.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat PB1 PF00564.24 EFX02398.1 - 8.9e-05 22.3 0.5 0.0002 21.3 0.5 1.6 1 0 0 1 1 1 1 PB1 domain TPR_17 PF13431.6 EFX02398.1 - 0.00016 21.8 0.1 0.26 11.7 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFX02398.1 - 0.0006 19.6 2.8 0.16 11.9 0.0 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX02398.1 - 0.00082 20.0 0.1 0.0074 16.9 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFX02398.1 - 0.0047 17.6 0.2 0.19 12.6 0.0 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 EFX02398.1 - 0.059 12.1 0.0 0.1 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) ANAPC5 PF12862.7 EFX02398.1 - 0.16 12.1 0.1 0.46 10.6 0.1 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 5 TPR_4 PF07721.14 EFX02398.1 - 0.2 12.4 1.5 46 5.1 0.0 3.8 4 1 0 4 4 2 0 Tetratricopeptide repeat RabGAP-TBC PF00566.18 EFX02399.1 - 6.4e-45 153.4 0.0 6.4e-45 153.4 0.0 2.6 3 0 0 3 3 3 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 EFX02399.1 - 1.3e-06 27.8 0.3 0.012 15.5 0.2 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFX02399.1 - 6.1e-05 22.3 0.5 0.16 11.5 0.7 3.5 3 0 0 3 3 3 2 EF hand GRAM PF02893.20 EFX02399.1 - 0.00017 21.5 0.0 0.00037 20.4 0.0 1.6 1 0 0 1 1 1 1 GRAM domain EF-hand_7 PF13499.6 EFX02399.1 - 0.0012 19.3 0.8 0.0046 17.4 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EFX02399.1 - 0.039 13.5 0.3 0.28 10.7 0.3 2.4 2 0 0 2 2 2 0 EF hand U1snRNP70_N PF12220.8 EFX02399.1 - 0.13 12.9 8.8 0.09 13.4 2.2 2.5 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3915 PF13054.6 EFX02399.1 - 3.4 7.7 8.4 9 6.3 8.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF1645 PF07816.11 EFX02399.1 - 6.1 7.4 8.8 14 6.2 2.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) QRPTase_C PF01729.19 EFX02400.1 - 7.7e-53 178.7 0.1 9.3e-53 178.5 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EFX02400.1 - 1.1e-19 70.3 0.0 3.7e-19 68.6 0.0 1.9 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain HlyD_D4 PF16572.5 EFX02400.1 - 0.051 13.4 0.7 1.1 9.1 0.1 2.7 2 0 0 2 2 2 0 Long alpha hairpin domain of cation efflux system protein, CusB Kelch_4 PF13418.6 EFX02401.1 - 2.2e-37 126.8 5.9 2.3e-07 30.7 0.8 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EFX02401.1 - 1.8e-30 104.6 9.8 3.6e-06 27.1 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFX02401.1 - 3.7e-30 103.2 3.4 6.6e-12 45.3 1.2 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EFX02401.1 - 1.4e-26 91.9 2.5 1.4e-06 28.1 0.2 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EFX02401.1 - 5.3e-26 89.9 1.4 2.3e-11 43.1 0.5 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFX02401.1 - 1.4e-18 66.1 5.4 1e-07 31.7 0.6 6.7 6 0 0 6 6 6 4 Kelch motif DivIC PF04977.15 EFX02401.1 - 0.056 13.2 0.1 0.056 13.2 0.1 6.2 7 1 2 9 9 9 0 Septum formation initiator PEX11 PF05648.14 EFX02402.1 - 6.4e-05 22.5 3.5 0.00012 21.6 3.5 1.5 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Methyltransf_10 PF05971.12 EFX02405.1 - 5e-54 183.7 0.0 8.5e-54 182.9 0.0 1.3 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EFX02405.1 - 0.00071 19.2 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFX02405.1 - 0.046 13.1 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AMP-binding PF00501.28 EFX02406.1 - 2.1e-79 267.1 0.0 2.7e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX02406.1 - 8e-18 65.2 0.2 1.9e-17 64.0 0.2 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF3322 PF11795.8 EFX02406.1 - 0.064 13.3 0.1 0.33 10.9 0.0 2.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Vps62 PF06101.11 EFX02407.1 - 3.7e-07 28.8 0.5 6.1e-06 24.8 0.0 2.2 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 Ank_2 PF12796.7 EFX02408.1 - 3.1e-37 127.0 0.1 3.6e-14 53.1 0.0 4.8 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX02408.1 - 1.2e-32 108.2 0.0 0.00018 21.7 0.0 8.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFX02408.1 - 1.6e-31 108.3 0.0 2.7e-10 40.6 0.0 5.5 6 1 2 8 8 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFX02408.1 - 3.4e-31 106.3 0.0 2.5e-05 24.5 0.0 7.1 8 0 0 8 8 7 4 Ankyrin repeat Ank_5 PF13857.6 EFX02408.1 - 1.4e-17 63.5 0.0 8.5e-05 22.8 0.0 5.0 2 1 3 5 5 4 4 Ankyrin repeats (many copies) NACHT PF05729.12 EFX02408.1 - 5.8e-08 32.8 0.1 1.4e-07 31.6 0.1 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFX02408.1 - 1.5e-05 25.4 0.0 4.5e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain DUF3734 PF12536.8 EFX02408.1 - 0.0054 17.0 0.0 6.2 7.2 0.0 4.1 3 1 2 5 5 5 1 Patatin phospholipase VWA_3_C PF18571.1 EFX02408.1 - 0.0072 16.2 10.2 2.5 8.0 0.4 4.5 4 0 0 4 4 4 2 von Willebrand factor type A C-terminal domain KAP_NTPase PF07693.14 EFX02408.1 - 0.0094 15.2 0.4 1.6 7.9 0.0 2.3 1 1 1 2 2 2 2 KAP family P-loop domain AAA_22 PF13401.6 EFX02408.1 - 0.016 15.5 0.0 0.048 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFX02408.1 - 0.018 15.5 0.0 0.07 13.7 0.0 2.0 2 0 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 EFX02408.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EFX02408.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFX02408.1 - 0.21 11.2 0.0 0.37 10.4 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EFX02409.1 - 8.4e-56 188.6 0.0 1.3e-55 187.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFX02409.1 - 4.7e-15 55.4 0.0 1.2e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFX02409.1 - 3.1e-09 37.1 0.0 9.6e-09 35.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFX02409.1 - 5.7e-07 29.5 0.0 1.6e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EFX02409.1 - 1.1e-05 25.1 0.0 0.00014 21.6 0.0 2.7 2 1 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EFX02409.1 - 0.059 13.5 0.0 0.16 12.1 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase zf-C2HC5 PF06221.13 EFX02410.1 - 7.8e-21 73.8 7.7 1.2e-20 73.2 7.7 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Angiomotin_C PF12240.8 EFX02412.1 - 0.024 14.2 0.5 0.029 13.9 0.5 1.1 1 0 0 1 1 1 0 Angiomotin C terminal DUF3328 PF11807.8 EFX02413.1 - 2.8e-45 154.8 0.2 3.3e-45 154.6 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DapH_N PF08503.10 EFX02414.1 - 0.049 13.9 0.0 0.092 13.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal DEAD PF00270.29 EFX02415.1 - 6.7e-45 153.0 0.5 1.1e-44 152.3 0.5 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX02415.1 - 2.2e-32 111.7 0.1 1.8e-31 108.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX02415.1 - 4.3e-05 23.6 0.0 7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFX02415.1 - 0.00015 21.5 0.1 0.00023 20.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX02415.1 - 0.0011 19.3 0.2 0.0059 17.0 0.1 2.0 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EFX02415.1 - 0.0066 16.3 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Helicase Flavi_DEAD PF07652.14 EFX02415.1 - 0.011 15.7 0.2 0.04 13.9 0.2 2.0 1 1 0 1 1 1 0 Flavivirus DEAD domain TniB PF05621.11 EFX02415.1 - 0.02 14.3 0.0 0.1 12.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_22 PF13401.6 EFX02415.1 - 0.033 14.5 0.3 0.094 13.0 0.3 1.7 1 1 0 1 1 1 0 AAA domain DUF5393 PF17371.2 EFX02415.1 - 0.05 11.7 0.1 0.088 10.9 0.1 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5393) RPE65 PF03055.15 EFX02417.1 - 4.1e-105 352.6 0.3 4.7e-105 352.5 0.3 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Fungal_trans PF04082.18 EFX02418.1 - 0.0024 16.9 0.1 0.005 15.9 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_19 PF04672.12 EFX02418.1 - 0.19 11.1 0.0 0.39 10.2 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl methyltransferase DEAD PF00270.29 EFX02419.1 - 6.3e-50 169.4 0.0 2.3e-48 164.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX02419.1 - 8.6e-33 113.0 0.1 3.2e-32 111.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX02419.1 - 1.6e-05 25.0 0.0 7e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EFX02419.1 - 0.0028 16.5 0.0 0.45 9.2 0.0 2.2 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DRTGG PF07085.12 EFX02419.1 - 0.0074 16.1 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 DRTGG domain AAA_19 PF13245.6 EFX02419.1 - 0.026 14.8 0.0 11 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFX02419.1 - 0.054 13.9 0.0 1.3 9.5 0.1 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX02419.1 - 0.16 12.2 0.8 14 6.0 0.0 3.3 4 0 0 4 4 4 0 AAA domain CMS1 PF14617.6 EFX02419.1 - 0.2 11.0 1.1 2 7.7 0.0 2.6 3 1 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit Glyco_transf_34 PF05637.12 EFX02421.1 - 5e-11 42.8 0.1 1.7e-08 34.5 0.1 2.5 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 EFX02421.1 - 0.016 14.8 0.3 0.25 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF273 SAPS PF04499.15 EFX02421.1 - 0.084 11.6 6.0 0.094 11.5 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 EFX02421.1 - 4.9 5.3 18.4 7.1 4.8 18.4 1.1 1 0 0 1 1 1 0 CDC45-like protein GIY-YIG PF01541.24 EFX02422.1 - 1.2e-11 44.7 0.0 2.3e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H_2 PF13832.6 EFX02422.1 - 0.0011 19.1 1.2 0.002 18.3 1.2 1.3 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EFX02422.1 - 0.0015 18.8 2.7 0.0027 17.9 2.7 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain FANCL_C PF11793.8 EFX02422.1 - 0.0031 17.7 3.9 0.005 17.0 3.9 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain YdjO PF14169.6 EFX02422.1 - 0.021 14.5 0.3 0.083 12.6 0.0 2.0 2 0 0 2 2 2 0 Cold-inducible protein YdjO T5orf172 PF10544.9 EFX02422.1 - 0.058 14.0 0.1 0.21 12.1 0.0 2.1 2 1 0 2 2 2 0 T5orf172 domain Prok-RING_1 PF14446.6 EFX02422.1 - 2.2 8.2 7.7 0.63 10.0 3.6 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 F-box-like PF12937.7 EFX02424.1 - 0.035 14.0 1.7 2 8.4 0.2 2.7 2 0 0 2 2 2 0 F-box-like Pro_isomerase PF00160.21 EFX02425.1 - 3e-51 173.8 0.0 3.4e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3830 PF12903.7 EFX02425.1 - 0.071 12.8 0.0 0.2 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3830) NIBRIN_BRCT_II PF16508.5 EFX02426.1 - 1.2e-37 128.9 0.0 4.5e-37 127.0 0.0 2.1 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 EFX02426.1 - 7.4e-09 35.8 0.2 1.3e-08 35.0 0.2 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFX02426.1 - 0.00017 21.8 0.0 0.0013 19.0 0.0 2.2 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 PF16770.5 EFX02426.1 - 0.0033 17.3 0.0 0.0068 16.3 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Fungal_trans_2 PF11951.8 EFX02427.1 - 1e-62 212.2 1.0 1.4e-62 211.7 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02427.1 - 2.4e-07 30.8 13.9 5.5e-07 29.6 13.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L13e PF01294.18 EFX02428.1 - 1.7e-69 233.3 0.1 2.2e-69 232.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Cyt-b5 PF00173.28 EFX02429.1 - 3.9e-13 49.3 0.0 5e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain S1 PF00575.23 EFX02430.1 - 2.4e-63 210.4 27.2 2.8e-11 43.6 0.0 12.6 12 0 0 12 12 12 12 S1 RNA binding domain RNase_II_C_S1 PF18614.1 EFX02430.1 - 1.3e-06 28.3 2.7 0.04 13.9 0.1 6.2 6 0 0 6 6 6 1 RNase II-type exonuclease C-terminal S1 domain TPR_14 PF13428.6 EFX02430.1 - 5.8e-06 26.7 0.1 9.3 7.4 0.0 5.9 2 1 4 6 6 6 2 Tetratricopeptide repeat Suf PF05843.14 EFX02430.1 - 3.1e-05 24.1 7.0 0.0014 18.7 4.0 3.5 1 1 1 2 2 2 1 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EFX02430.1 - 0.00028 21.3 0.4 0.14 12.7 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat ID PF18543.1 EFX02430.1 - 0.04 13.9 0.0 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 Intracellular delivery domain NRDE-2 PF08424.10 EFX02430.1 - 0.12 11.5 4.1 0.72 8.9 0.2 2.8 1 1 1 2 2 2 0 NRDE-2, necessary for RNA interference MFS_1 PF07690.16 EFX02432.1 - 1.9e-08 33.6 15.7 0.00011 21.2 1.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_A22B PF04258.13 EFX02434.1 - 4.5e-55 187.2 0.4 3.9e-36 125.0 0.0 2.5 2 1 0 2 2 2 2 Signal peptide peptidase Rbsn PF11464.8 EFX02435.1 - 2.1e-18 65.8 1.3 5.6e-18 64.4 1.3 1.8 1 0 0 1 1 1 1 Rabenosyn Rab binding domain FYVE PF01363.21 EFX02435.1 - 1.1e-17 63.9 9.3 1.1e-16 60.7 6.2 2.3 2 0 0 2 2 2 1 FYVE zinc finger HypA PF01155.19 EFX02435.1 - 0.0044 17.0 2.1 0.01 15.9 0.3 2.4 2 1 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C6_DPF PF10170.9 EFX02435.1 - 0.016 15.6 0.4 0.044 14.1 0.4 1.7 1 0 0 1 1 1 0 Cysteine-rich domain ABC_tran_CTD PF16326.5 EFX02435.1 - 0.042 14.1 7.3 1.7 8.9 0.1 3.3 2 1 0 2 2 2 0 ABC transporter C-terminal domain TMF_TATA_bd PF12325.8 EFX02435.1 - 0.14 12.4 5.1 0.16 12.2 1.7 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 EFX02435.1 - 0.45 9.4 2.5 1.7 7.5 0.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 EFX02435.1 - 0.47 10.6 4.4 7.6 6.7 0.0 3.2 3 0 0 3 3 3 0 bZIP transcription factor Csm1_N PF18504.1 EFX02435.1 - 0.8 10.1 6.5 2.5 8.5 0.1 3.3 2 1 1 3 3 3 0 Csm1 N-terminal domain SlyX PF04102.12 EFX02435.1 - 1.7 9.3 8.9 9.7 6.9 0.2 3.7 5 0 0 5 5 4 0 SlyX Med9 PF07544.13 EFX02435.1 - 3 8.0 5.1 42 4.3 0.7 2.9 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4140 PF13600.6 EFX02435.1 - 4.4 7.8 6.1 25 5.4 1.9 3.5 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) FTR PF01913.18 EFX02436.1 - 0.049 13.6 1.2 0.093 12.7 1.2 1.5 1 0 0 1 1 1 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase LigB PF02900.18 EFX02438.1 - 2.1e-35 122.1 0.0 2.8e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase NDK PF00334.19 EFX02439.1 - 3.9e-53 179.1 0.0 4.4e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase SIR2 PF02146.17 EFX02440.1 - 7.7e-54 182.3 0.0 1e-53 181.9 0.0 1.1 1 0 0 1 1 1 1 Sir2 family zf-LYAR PF08790.11 EFX02440.1 - 0.011 15.6 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger DTHCT PF08070.11 EFX02440.1 - 0.011 16.4 0.2 0.019 15.7 0.2 1.3 1 0 0 1 1 1 0 DTHCT (NUC029) region Pup PF05639.11 EFX02440.1 - 0.56 11.1 2.9 0.7 10.8 0.5 2.1 2 0 0 2 2 2 0 Pup-like protein ABC_tran PF00005.27 EFX02441.1 - 8.1e-48 162.4 0.0 2.9e-27 95.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFX02441.1 - 1.5e-33 116.6 19.2 6.7e-18 65.3 3.5 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFX02441.1 - 8.9e-10 38.4 6.1 0.011 15.2 0.9 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFX02441.1 - 1.3e-07 31.3 0.7 0.0075 16.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 EFX02441.1 - 4.2e-06 26.5 0.1 0.039 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EFX02441.1 - 8.8e-05 23.1 0.4 0.058 13.9 0.2 2.3 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EFX02441.1 - 8.9e-05 22.4 1.5 0.34 10.7 1.0 3.6 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFX02441.1 - 9.2e-05 22.5 2.4 0.29 11.2 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF87 PF01935.17 EFX02441.1 - 0.00014 22.0 2.8 0.055 13.6 0.4 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain Dynamin_N PF00350.23 EFX02441.1 - 0.00017 21.7 3.7 0.03 14.4 0.2 2.6 2 0 0 2 2 2 2 Dynamin family FtsK_SpoIIIE PF01580.18 EFX02441.1 - 0.00047 19.6 0.2 0.72 9.2 0.1 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.6 EFX02441.1 - 0.00061 20.1 0.9 1.6 9.0 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX02441.1 - 0.0025 18.2 1.0 3.6 7.9 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFX02441.1 - 0.0031 17.4 4.1 0.25 11.2 0.1 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_24 PF13479.6 EFX02441.1 - 0.0038 17.0 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain Pox_A32 PF04665.12 EFX02441.1 - 0.012 15.1 2.6 3 7.3 0.1 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein ATP_bind_1 PF03029.17 EFX02441.1 - 0.016 15.0 1.9 16 5.2 0.1 3.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein SbcCD_C PF13558.6 EFX02441.1 - 0.028 14.6 0.1 6.5 7.1 0.0 3.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.18 EFX02441.1 - 0.031 14.0 0.0 1.5 8.5 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EFX02441.1 - 0.048 13.4 2.0 13 5.4 0.0 3.3 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFX02441.1 - 0.1 12.6 1.5 21 5.1 0.1 3.8 5 0 0 5 5 3 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EFX02441.1 - 0.12 11.5 3.6 7.6 5.6 0.2 3.1 3 0 0 3 3 3 0 NB-ARC domain NACHT PF05729.12 EFX02441.1 - 0.16 11.9 2.1 11 5.9 0.2 2.6 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 EFX02441.1 - 0.18 12.0 0.0 19 5.5 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EFX02441.1 - 0.25 11.5 3.9 6.7 6.9 0.1 2.9 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFX02441.1 - 0.38 11.1 1.7 65 4.0 0.1 3.6 3 0 0 3 3 3 0 RNA helicase IstB_IS21 PF01695.17 EFX02441.1 - 0.4 10.4 3.7 6.3 6.5 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EFX02441.1 - 1.2 9.0 3.0 28 4.6 0.1 3.2 3 0 0 3 3 3 0 NTPase AAA_28 PF13521.6 EFX02441.1 - 7.3 6.8 5.7 6.7 6.9 0.7 2.8 2 1 0 2 2 2 0 AAA domain GAS PF13851.6 EFX02442.1 - 0.00085 18.7 4.1 0.0011 18.4 4.1 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EFX02442.1 - 0.001 19.4 0.1 0.0013 19.0 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 EFX02442.1 - 0.0023 18.0 4.5 0.0023 18.0 4.5 1.8 2 0 0 2 2 2 1 bZIP transcription factor HALZ PF02183.18 EFX02442.1 - 0.0088 16.2 1.1 0.013 15.7 0.5 1.6 2 0 0 2 2 1 1 Homeobox associated leucine zipper Methyltransf_22 PF13383.6 EFX02442.1 - 0.017 14.7 0.2 0.025 14.1 0.2 1.1 1 0 0 1 1 1 0 Methyltransferase domain RILP PF11461.8 EFX02442.1 - 0.03 14.6 0.9 0.091 13.0 0.9 1.8 1 0 0 1 1 1 0 Rab interacting lysosomal protein Macoilin PF09726.9 EFX02442.1 - 0.032 12.8 3.4 0.041 12.5 3.4 1.1 1 0 0 1 1 1 0 Macoilin family Fib_alpha PF08702.10 EFX02442.1 - 0.067 13.4 1.5 0.092 12.9 1.5 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Bcr-Abl_Oligo PF09036.10 EFX02442.1 - 0.084 12.9 0.8 0.15 12.1 0.2 1.6 1 1 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain Med9 PF07544.13 EFX02442.1 - 0.13 12.3 2.4 0.23 11.6 2.4 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 TMF_DNA_bd PF12329.8 EFX02442.1 - 0.16 12.0 6.4 0.27 11.3 6.4 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4798 PF16055.5 EFX02442.1 - 0.22 11.8 5.4 0.14 12.4 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4798) DUF1664 PF07889.12 EFX02442.1 - 0.7 9.9 3.2 1 9.4 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.15 EFX02442.1 - 0.76 9.6 3.8 1.1 9.1 2.7 1.7 1 1 1 2 2 2 0 Septum formation initiator Spc29 PF17082.5 EFX02442.1 - 1.4 8.7 6.8 2.5 7.9 0.4 2.1 1 1 1 2 2 2 0 Spindle Pole Component 29 K-box PF01486.17 EFX02442.1 - 2.5 8.3 8.5 12 6.2 0.2 2.4 1 1 2 3 3 3 0 K-box region Glyco_hydro_31 PF01055.26 EFX02443.1 - 2.9e-141 471.6 1.7 4.1e-141 471.2 1.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFX02443.1 - 7.6e-22 77.4 0.3 3.3e-21 75.4 0.1 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EFX02443.1 - 5.8e-07 29.7 0.3 2.8e-06 27.5 0.3 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Hemerythrin PF01814.23 EFX02444.1 - 1.2e-10 42.2 1.7 2.1e-10 41.3 1.7 1.3 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain EF-hand_9 PF14658.6 EFX02444.1 - 0.036 14.4 0.0 0.074 13.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain TPR_9 PF13371.6 EFX02444.1 - 0.049 13.8 0.2 0.14 12.3 0.2 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat DNA_ligase_A_N PF04675.14 EFX02445.1 - 1.7e-22 80.5 0.0 3.3e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 EFX02445.1 - 7e-11 42.2 0.0 2.3e-06 27.4 0.0 2.2 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Dynactin_p62 PF05502.13 EFX02446.1 - 1.7e-191 637.2 0.0 2.2e-191 636.8 0.0 1.1 1 0 0 1 1 1 1 Dynactin p62 family zf-FPG_IleRS PF06827.14 EFX02446.1 - 4.5 7.2 12.8 2.1 8.3 0.2 4.1 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS TauD PF02668.16 EFX02447.1 - 4.6e-30 105.3 0.3 6.6e-30 104.8 0.3 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EFX02447.1 - 0.048 12.8 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 CsiD DUF3455 PF11937.8 EFX02448.1 - 7.7e-31 107.6 0.0 1.5e-30 106.6 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) TbpB_C PF17483.2 EFX02449.1 - 0.1 13.0 0.1 8.9 6.7 0.0 2.2 2 0 0 2 2 2 0 C-lobe handle domain of Tf-binding protein B Amino_oxidase PF01593.24 EFX02450.1 - 0.00033 20.1 0.0 0.00045 19.6 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase ATP-synt_10 PF05176.14 EFX02451.1 - 2.3e-22 79.5 0.0 2.8e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein Fungal_trans PF04082.18 EFX02452.1 - 5.7e-28 97.7 0.0 8.9e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain IBR PF01485.21 EFX02452.1 - 3.8e-09 36.6 17.6 1.8e-06 28.1 4.2 3.7 3 0 0 3 3 2 2 IBR domain, a half RING-finger domain Zn_clus PF00172.18 EFX02452.1 - 0.00015 21.8 0.4 0.00015 21.8 0.4 2.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CCCH_4 PF18044.1 EFX02452.1 - 0.001 18.8 1.9 0.001 18.8 1.9 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFX02452.1 - 0.001 19.0 4.1 0.0025 17.8 4.1 1.7 1 0 0 1 1 1 1 Zinc finger domain SUIM_assoc PF16619.5 EFX02452.1 - 0.0037 17.3 3.9 0.89 9.7 0.7 2.8 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 JSRP PF15312.6 EFX02452.1 - 0.017 15.0 0.1 0.052 13.5 0.1 1.8 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein Torus PF16131.5 EFX02452.1 - 0.021 15.5 0.0 0.093 13.4 0.0 2.1 1 0 0 1 1 1 0 Torus domain zf-CCCH PF00642.24 EFX02452.1 - 0.031 14.2 2.4 0.088 12.8 2.4 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2126 PF09899.9 EFX02452.1 - 0.11 10.6 0.1 3.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) zf-CCCH_2 PF14608.6 EFX02452.1 - 2.1 8.9 7.5 0.48 11.0 2.9 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger GST_C_2 PF13410.6 EFX02453.1 - 1.4e-06 28.2 0.9 2.9e-06 27.2 0.9 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFX02453.1 - 1.2e-05 25.6 0.1 2.6e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFX02453.1 - 0.0065 16.7 0.0 0.018 15.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFX02453.1 - 0.014 15.7 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Sec3_C PF09763.9 EFX02454.1 - 1.5e-225 750.8 0.0 2e-225 750.4 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EFX02454.1 - 8.5e-29 99.5 0.1 1.5e-28 98.8 0.1 1.4 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.6 EFX02454.1 - 0.00072 19.8 2.4 0.0066 16.8 0.1 2.8 3 0 0 3 3 3 1 Sec3 exocyst complex subunit IL32 PF15225.6 EFX02454.1 - 0.077 13.4 1.0 3.3 8.1 0.0 3.1 3 0 0 3 3 3 0 Interleukin 32 Vps52 PF04129.12 EFX02454.1 - 0.093 11.5 1.9 0.45 9.2 0.1 2.5 3 0 0 3 3 3 0 Vps52 / Sac2 family Nse4-Nse3_bdg PF15412.6 EFX02454.1 - 0.099 12.8 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE ABC_tran_CTD PF16326.5 EFX02454.1 - 1.6 9.1 4.6 20 5.5 0.1 3.5 3 0 0 3 3 3 0 ABC transporter C-terminal domain Ras PF00071.22 EFX02455.1 - 2.3e-12 46.8 0.0 9.2e-05 22.1 0.0 3.6 3 1 0 3 3 3 3 Ras family AAA_16 PF13191.6 EFX02455.1 - 1.7e-05 25.3 0.3 6e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EFX02455.1 - 7.8e-05 22.9 0.0 0.00025 21.3 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 EFX02455.1 - 0.0029 17.0 0.0 0.0061 16.0 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFX02455.1 - 0.0063 16.7 1.7 1.6 8.8 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA PF00004.29 EFX02455.1 - 0.0068 16.8 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX02455.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFX02455.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EFX02455.1 - 0.079 12.5 0.1 0.24 11.0 0.1 2.0 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EFX02455.1 - 0.099 12.0 0.0 0.3 10.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein NACHT PF05729.12 EFX02455.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EFX02455.1 - 0.13 12.5 0.1 0.34 11.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFX02455.1 - 0.14 11.9 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain V-SNARE_C PF12352.8 EFX02457.1 - 4.5e-05 23.7 3.0 4.5e-05 23.7 3.0 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V_ATPase_I PF01496.19 EFX02457.1 - 5.2 4.8 9.0 6.2 4.6 9.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3847 PF12958.7 EFX02457.1 - 6.4 7.0 9.4 1.6 8.9 0.8 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3847) RhoGAP PF00620.27 EFX02458.1 - 8e-36 123.2 0.0 2e-35 121.8 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EFX02458.1 - 2.9e-29 101.1 38.5 2e-11 43.9 6.6 4.9 5 0 0 5 5 5 4 LIM domain Phos_pyr_kin PF08543.12 EFX02459.1 - 3.1e-10 39.8 0.0 5.9e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EFX02459.1 - 1e-06 28.3 0.0 6e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Alb1 PF09135.11 EFX02460.1 - 3.8e-29 101.6 11.1 5.2e-29 101.2 11.1 1.2 1 0 0 1 1 1 1 Alb1 MADF_DNA_bdg PF10545.9 EFX02460.1 - 0.18 12.1 0.7 0.47 10.8 0.7 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Fungal_trans PF04082.18 EFX02461.1 - 2.1e-19 69.6 0.0 7.5e-19 67.8 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02461.1 - 1.9e-07 31.1 7.6 1.9e-07 31.1 7.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PDR_CDR PF06422.12 EFX02461.1 - 0.17 11.8 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 CDR ABC transporter 3HCDH_N PF02737.18 EFX02462.1 - 2.5e-19 69.9 0.0 6.1e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EFX02462.1 - 1e-11 45.3 0.0 2.4e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DUF676 PF05057.14 EFX02462.1 - 5.2e-06 26.1 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) NACHT PF05729.12 EFX02462.1 - 0.00021 21.3 0.0 0.00045 20.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PGAP1 PF07819.13 EFX02462.1 - 0.0014 18.4 0.5 0.0053 16.5 0.5 1.9 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFX02462.1 - 0.0016 19.1 0.0 0.005 17.5 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family WD40 PF00400.32 EFX02462.1 - 0.0082 17.0 0.7 0.91 10.5 0.0 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat Lipase_2 PF01674.18 EFX02462.1 - 0.016 14.8 0.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 Lipase (class 2) Hydrolase_4 PF12146.8 EFX02462.1 - 0.13 11.5 0.1 0.76 9.0 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 EF1_GNE PF00736.19 EFX02463.1 - 2.9e-31 107.5 1.1 5.5e-31 106.6 1.1 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EFX02463.1 - 9.1e-14 51.6 9.4 9.1e-14 51.6 9.4 2.4 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 EFX02463.1 - 0.0023 18.1 0.5 0.013 15.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain UBA2_C PF16195.5 EFX02463.1 - 0.008 16.8 3.8 0.014 16.1 3.8 1.4 1 0 0 1 1 1 1 SUMO-activating enzyme subunit 2 C-terminus GST_C PF00043.25 EFX02463.1 - 0.015 15.5 1.7 0.023 14.9 0.1 2.1 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Vezatin PF12632.7 EFX02464.1 - 6e-70 235.8 0.0 8.2e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes Fructosamin_kin PF03881.14 EFX02465.1 - 3.1e-35 121.8 0.4 4e-35 121.4 0.4 1.0 1 0 0 1 1 1 1 Fructosamine kinase GTP_EFTU PF00009.27 EFX02466.1 - 4e-08 33.0 0.0 6.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain T2SSE PF00437.20 EFX02466.1 - 0.00016 20.8 0.2 0.00028 20.0 0.2 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EFX02466.1 - 0.0014 18.6 2.5 0.18 11.7 1.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EFX02466.1 - 0.0015 19.0 0.4 0.0052 17.2 0.1 1.9 1 1 1 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EFX02466.1 - 0.0032 18.0 0.1 0.0068 16.9 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFX02466.1 - 0.012 15.3 2.1 0.028 14.2 2.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EFX02466.1 - 0.016 15.0 1.2 6 6.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MeaB PF03308.16 EFX02466.1 - 0.038 13.0 2.0 0.068 12.1 0.8 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EFX02466.1 - 0.088 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFX02466.1 - 0.17 12.4 0.8 0.23 12.0 0.1 1.4 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 EFX02468.1 - 3.9e-79 264.1 0.1 4.6e-79 263.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFX02468.1 - 1.6e-14 54.1 0.0 2.2e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFX02468.1 - 6.2e-14 51.8 0.0 7.8e-14 51.5 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFX02468.1 - 3.4e-13 49.5 0.0 3.8e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFX02468.1 - 4.8e-13 49.0 1.3 4.5e-09 35.9 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFX02468.1 - 1.8e-10 40.6 0.0 2.3e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFX02468.1 - 2.4e-06 27.6 0.0 3.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EFX02468.1 - 0.0065 15.8 0.4 0.025 13.9 0.1 1.8 2 0 0 2 2 2 1 6-phosphofructo-2-kinase AAA_31 PF13614.6 EFX02468.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain zf-C2H2_4 PF13894.6 EFX02469.1 - 3.2e-07 30.6 28.4 0.0011 19.6 1.3 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX02469.1 - 9.6e-06 25.8 2.1 9.6e-06 25.8 2.1 5.5 5 1 1 6 6 6 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFX02469.1 - 8.6e-05 22.8 1.4 8.6e-05 22.8 1.4 7.7 7 2 1 8 8 8 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFX02469.1 - 0.018 15.4 7.2 0.11 12.8 0.1 4.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EFX02469.1 - 0.46 11.2 20.6 1.5 9.5 0.0 5.5 6 0 0 6 6 6 0 FOXP coiled-coil domain zf-C2H2_3rep PF18868.1 EFX02469.1 - 2.4 8.9 15.6 11 6.8 5.7 4.0 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats RPAP2_Rtr1 PF04181.13 EFX02469.1 - 8 6.9 8.3 0.38 11.1 1.2 2.4 3 0 0 3 3 3 0 Rtr1/RPAP2 family Gpi16 PF04113.14 EFX02470.1 - 5e-245 814.2 0.0 5.8e-245 814.0 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component SKG6 PF08693.10 EFX02471.1 - 0.065 12.6 0.0 0.065 12.6 0.0 2.5 3 0 0 3 3 3 0 Transmembrane alpha-helix domain DUF4328 PF14219.6 EFX02471.1 - 0.21 11.1 0.0 0.21 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4328) GFO_IDH_MocA PF01408.22 EFX02472.1 - 3.9e-09 37.4 0.6 1.2e-08 35.9 0.6 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding_2 PF13380.6 EFX02472.1 - 0.1 13.1 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 CoA binding domain NAD_binding_3 PF03447.16 EFX02472.1 - 0.15 12.7 0.0 0.35 11.5 0.0 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain dUTPase PF00692.19 EFX02473.1 - 9.9e-41 138.4 0.0 1.3e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 dUTPase Cgr1 PF03879.14 EFX02474.1 - 7.5e-32 109.9 26.6 8.5e-32 109.7 26.6 1.0 1 0 0 1 1 1 1 Cgr1 family RR_TM4-6 PF06459.12 EFX02474.1 - 0.6 9.9 11.1 0.63 9.8 11.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 COX16 PF14138.6 EFX02474.1 - 3.4 8.3 12.2 5.7 7.5 11.5 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Nop16 PF09420.10 EFX02475.1 - 1e-49 169.4 1.0 1e-49 169.4 1.0 1.9 2 0 0 2 2 2 1 Ribosome biogenesis protein Nop16 ANAPC3 PF12895.7 EFX02475.1 - 3.9e-25 87.9 10.0 4e-23 81.4 1.3 4.4 2 1 3 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EFX02475.1 - 4.3e-23 80.1 2.5 0.008 16.0 0.0 9.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02475.1 - 6.1e-23 79.0 21.2 0.0053 16.8 0.0 11.2 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_19 PF14559.6 EFX02475.1 - 7.8e-22 77.6 13.7 0.0021 18.5 0.1 7.8 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02475.1 - 3.2e-14 51.9 0.1 4.8 7.7 0.0 9.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02475.1 - 4.2e-13 49.4 34.4 6.3e-06 26.4 0.1 9.8 7 2 3 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 EFX02475.1 - 5.9e-09 36.0 40.4 0.046 14.5 0.0 11.4 8 3 3 11 11 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFX02475.1 - 1.1e-08 35.6 48.4 0.00019 22.0 0.1 10.1 9 2 2 11 11 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02475.1 - 3.8e-08 32.8 11.7 0.62 10.2 0.0 8.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX02475.1 - 9.2e-08 31.7 23.0 0.0031 17.3 0.1 8.0 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFX02475.1 - 2.9e-06 26.9 0.2 1.5 8.6 0.0 6.0 5 1 2 7 7 7 2 TPR repeat Coatomer_E PF04733.14 EFX02475.1 - 8.6e-05 22.1 0.0 1.7 8.0 0.0 3.7 2 1 1 3 3 3 2 Coatomer epsilon subunit HrpB1_HrpK PF09613.10 EFX02475.1 - 0.00077 19.1 0.1 0.044 13.4 0.0 3.0 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_9 PF13371.6 EFX02475.1 - 0.0049 17.0 8.6 0.044 13.9 0.2 4.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX02475.1 - 0.059 14.0 15.6 6.8 7.6 0.1 8.3 9 1 1 10 10 8 0 Tetratricopeptide repeat Dpy-30 PF05186.13 EFX02475.1 - 1.1 9.0 4.1 6.9 6.5 0.0 3.8 4 0 0 4 4 4 0 Dpy-30 motif Alkyl_sulf_dimr PF14863.6 EFX02475.1 - 5.4 7.5 7.9 28 5.1 0.0 4.5 5 0 0 5 5 5 0 Alkyl sulfatase dimerisation TPR_4 PF07721.14 EFX02475.1 - 6.1 7.8 0.0 3.4 8.6 0.0 9.3 10 0 0 10 10 6 0 Tetratricopeptide repeat Proteasom_Rpn13 PF04683.13 EFX02476.1 - 4.9e-23 81.5 0.0 7.7e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EFX02476.1 - 1.3e-08 35.0 0.3 2.5e-07 30.8 0.3 2.2 1 1 0 1 1 1 1 UCH-binding domain ATG16 PF08614.11 EFX02477.1 - 0.49 10.6 1.6 0.56 10.4 1.6 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GRP PF07172.11 EFX02479.1 - 0.024 15.3 1.0 0.024 15.3 1.0 2.8 3 0 0 3 3 3 0 Glycine rich protein family DUF2207 PF09972.9 EFX02479.1 - 0.23 10.2 0.1 3 6.5 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4235 PF14019.6 EFX02479.1 - 2.6 8.2 7.9 0.18 11.9 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) DAO PF01266.24 EFX02480.1 - 4.3e-59 200.9 8.5 5.7e-59 200.5 8.5 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX02480.1 - 0.00019 21.6 0.7 0.00066 19.9 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFX02480.1 - 0.00047 20.7 0.1 0.73 10.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX02480.1 - 0.012 14.8 0.8 2.9 7.0 0.1 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX02480.1 - 0.15 10.9 0.7 2.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Tryptophan halogenase RRM_1 PF00076.22 EFX02483.1 - 1.2e-11 44.2 0.1 0.00011 21.9 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFX02483.1 - 0.14 12.1 0.0 1.4 8.8 0.1 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif p450 PF00067.22 EFX02484.1 - 7.3e-60 203.0 0.0 9.3e-58 196.1 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 Med7 PF05983.11 EFX02485.1 - 8.5e-12 45.5 2.1 1.2e-11 45.1 2.1 1.2 1 0 0 1 1 1 1 MED7 protein Rox3 PF08633.10 EFX02486.1 - 2.1e-70 237.2 0.5 7.8e-70 235.3 0.0 1.8 2 0 0 2 2 2 1 Rox3 mediator complex subunit GSHPx PF00255.19 EFX02487.1 - 1.4e-39 134.0 0.1 1.8e-39 133.7 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 EFX02487.1 - 0.0014 18.3 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EFX02487.1 - 0.003 17.5 0.1 0.0045 16.9 0.1 1.5 1 1 0 1 1 1 1 AhpC/TSA family AAA_18 PF13238.6 EFX02488.1 - 5.3e-09 36.7 0.0 1.3e-08 35.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX02488.1 - 1.5e-08 34.9 0.0 2e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 EFX02488.1 - 1.9e-08 34.6 0.0 2.2e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase Cytidylate_kin PF02224.18 EFX02488.1 - 3.7e-05 23.6 0.0 5.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase AAA PF00004.29 EFX02488.1 - 7e-05 23.3 0.1 0.00011 22.7 0.1 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EFX02488.1 - 0.00013 22.4 0.0 0.00032 21.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX02488.1 - 0.00023 21.6 0.0 0.0003 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFX02488.1 - 0.00031 21.0 0.0 0.00044 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EFX02488.1 - 0.0013 18.7 0.0 0.0034 17.3 0.0 1.7 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 EFX02488.1 - 0.0016 17.9 0.0 0.0023 17.3 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI dNK PF01712.19 EFX02488.1 - 0.0026 17.7 0.0 0.094 12.6 0.0 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase PhoH PF02562.16 EFX02488.1 - 0.0035 16.8 0.1 0.0057 16.1 0.1 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_28 PF13521.6 EFX02488.1 - 0.0049 17.1 0.0 0.0076 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFX02488.1 - 0.0061 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EFX02488.1 - 0.014 15.1 0.1 0.022 14.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFX02488.1 - 0.019 14.9 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain T2SSE PF00437.20 EFX02488.1 - 0.02 14.0 0.2 0.03 13.4 0.2 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EFX02488.1 - 0.032 14.1 0.3 0.064 13.2 0.1 1.5 2 0 0 2 2 1 0 NTPase RNA_helicase PF00910.22 EFX02488.1 - 0.047 14.1 0.0 0.085 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EFX02488.1 - 0.049 12.9 0.0 0.059 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) CPT PF07931.12 EFX02488.1 - 0.051 13.4 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.6 EFX02488.1 - 0.064 12.8 0.5 0.11 12.0 0.4 1.4 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFX02488.1 - 0.065 13.2 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFX02488.1 - 0.072 13.1 0.0 0.34 10.9 0.0 1.9 1 1 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFX02488.1 - 0.078 12.9 0.0 0.11 12.4 0.0 1.3 1 1 0 1 1 1 0 Adenylylsulphate kinase ABC_tran PF00005.27 EFX02488.1 - 0.096 13.2 0.0 0.12 12.9 0.0 1.3 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 EFX02488.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 EFX02488.1 - 0.1 12.4 0.2 0.21 11.4 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 EFX02488.1 - 0.12 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EFX02488.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 EFX02488.1 - 0.17 11.6 0.1 0.31 10.8 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein IPT PF01745.16 EFX02488.1 - 0.2 11.0 0.0 0.59 9.5 0.0 1.7 1 1 1 2 2 2 0 Isopentenyl transferase AAA_19 PF13245.6 EFX02488.1 - 0.2 12.0 0.1 0.35 11.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFX02488.1 - 0.2 11.3 0.0 0.4 10.3 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 EFX02488.1 - 0.2 11.3 0.5 0.47 10.1 0.4 1.5 1 1 0 1 1 1 0 AAA domain DHDPS PF00701.22 EFX02489.1 - 1.4e-31 109.3 0.0 1.9e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family FAT PF02259.23 EFX02490.1 - 1.2e-69 235.2 1.3 3.2e-69 233.8 1.3 1.8 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EFX02490.1 - 1.1e-30 107.3 0.0 2.7e-30 106.0 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EFX02490.1 - 1.4e-05 24.8 0.1 4.2e-05 23.3 0.1 1.9 1 0 0 1 1 1 1 FATC domain Spt20 PF12090.8 EFX02490.1 - 0.39 10.3 7.1 0.89 9.1 7.1 1.5 1 0 0 1 1 1 0 Spt20 family DUF4607 PF15380.6 EFX02490.1 - 0.41 10.1 2.8 0.94 8.9 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4607) DUF1473 PF07341.11 EFX02490.1 - 0.77 9.5 3.2 1.3 8.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1473) Glyco_hydro_16 PF00722.21 EFX02491.1 - 1.8e-07 30.8 1.1 8.7e-07 28.6 0.1 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Cnn_1N PF07989.11 EFX02492.1 - 1e-21 76.9 8.4 1e-21 76.9 8.4 10.8 7 3 3 11 11 11 3 Centrosomin N-terminal motif 1 PET PF06297.14 EFX02492.1 - 0.078 13.3 4.9 0.26 11.6 2.1 2.8 2 0 0 2 2 2 0 PET Domain MbeD_MobD PF04899.12 EFX02492.1 - 0.36 11.0 0.1 0.36 11.0 0.1 6.3 7 1 0 7 7 7 0 MbeD/MobD like Cad PF03596.13 EFX02493.1 - 6.3e-23 81.7 0.0 1e-22 81.0 0.0 1.2 1 0 0 1 1 1 1 Cadmium resistance transporter V-SNARE_C PF12352.8 EFX02494.1 - 2.4e-13 50.2 0.1 2.4e-13 50.2 0.1 2.9 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Atg14 PF10186.9 EFX02494.1 - 0.0008 18.6 6.0 0.00099 18.3 6.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Not3 PF04065.15 EFX02494.1 - 0.01 15.2 4.3 0.068 12.6 3.9 2.0 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Leu_zip PF15294.6 EFX02494.1 - 0.016 14.8 5.7 0.022 14.3 5.7 1.1 1 0 0 1 1 1 0 Leucine zipper STAT_alpha PF01017.20 EFX02494.1 - 0.043 13.7 4.2 0.085 12.7 3.5 1.8 1 1 0 1 1 1 0 STAT protein, all-alpha domain YscO PF07321.12 EFX02494.1 - 0.057 13.4 10.3 0.7 9.8 2.6 2.3 2 0 0 2 2 2 0 Type III secretion protein YscO Het-C PF07217.11 EFX02494.1 - 0.085 11.4 0.3 0.44 9.0 0.1 1.9 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C Spc7 PF08317.11 EFX02494.1 - 0.11 11.4 10.2 0.31 9.9 10.2 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein FTCD_C PF04961.12 EFX02494.1 - 0.17 11.7 2.8 2 8.2 0.1 2.2 1 1 2 3 3 3 0 Formiminotransferase-cyclodeaminase Csm1_N PF18504.1 EFX02494.1 - 0.26 11.6 8.2 1.5 9.2 0.7 3.5 3 1 1 4 4 4 0 Csm1 N-terminal domain TEX13 PF15186.6 EFX02494.1 - 0.44 10.2 6.8 0.079 12.6 1.8 2.0 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family Fib_alpha PF08702.10 EFX02494.1 - 0.55 10.4 5.1 2.6 8.2 4.3 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 EFX02494.1 - 0.61 10.7 9.3 3.6 8.2 2.6 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal UPF0184 PF03670.13 EFX02494.1 - 0.61 10.5 3.1 23 5.5 0.3 2.8 3 0 0 3 3 2 0 Uncharacterised protein family (UPF0184) DUF2203 PF09969.9 EFX02494.1 - 0.74 10.5 4.6 4.6 8.0 0.8 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Mis14 PF08641.12 EFX02494.1 - 1.4 9.3 8.5 2.2 8.6 8.0 1.5 1 1 0 1 1 1 0 Kinetochore protein Mis14 like ZapB PF06005.12 EFX02494.1 - 1.7 9.2 9.8 14 6.2 5.5 2.5 2 0 0 2 2 2 0 Cell division protein ZapB FUSC PF04632.12 EFX02494.1 - 1.8 7.0 7.7 2.1 6.8 7.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Swi5 PF07061.11 EFX02494.1 - 2.6 8.2 7.1 1.2e+02 2.8 6.9 2.7 1 1 1 2 2 2 0 Swi5 APG6_N PF17675.1 EFX02494.1 - 3.1 8.3 12.5 13 6.3 12.6 1.8 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 EFX02494.1 - 3.7 6.8 11.0 1.6 8.0 1.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GAS PF13851.6 EFX02494.1 - 4.1 6.7 12.7 8 5.8 1.1 2.3 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Mod_r PF07200.13 EFX02494.1 - 4.4 7.4 13.0 11 6.2 4.7 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Snapin_Pallidin PF14712.6 EFX02494.1 - 4.6 7.7 12.0 1.5 9.3 6.0 2.6 3 0 0 3 3 3 0 Snapin/Pallidin PilO PF04350.13 EFX02494.1 - 9.7 6.3 8.0 1.1 9.4 0.6 2.6 2 1 2 4 4 4 0 Pilus assembly protein, PilO AAA_2 PF07724.14 EFX02496.1 - 8.3e-43 146.5 0.0 1e-41 142.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFX02496.1 - 2.5e-36 123.7 2.1 2.5e-36 123.7 2.1 2.5 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EFX02496.1 - 1.5e-23 82.7 0.1 4.2e-23 81.2 0.1 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EFX02496.1 - 8.9e-19 68.2 0.0 5e-10 39.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX02496.1 - 1.2e-12 48.0 0.0 7.9e-09 35.6 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFX02496.1 - 2.4e-09 37.8 7.4 0.00047 20.6 0.2 4.2 3 2 0 3 3 2 2 AAA ATPase domain Sigma54_activat PF00158.26 EFX02496.1 - 6.3e-09 35.8 0.2 0.00039 20.2 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EFX02496.1 - 1.5e-07 31.8 3.3 0.016 15.5 0.0 4.0 3 2 0 3 3 3 2 AAA domain TniB PF05621.11 EFX02496.1 - 5.3e-06 26.0 0.0 0.003 17.0 0.0 3.5 3 1 0 3 3 2 1 Bacterial TniB protein ATPase_2 PF01637.18 EFX02496.1 - 1e-05 25.6 0.3 2.4 8.0 0.0 3.9 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFX02496.1 - 1.8e-05 24.4 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 EFX02496.1 - 2.2e-05 24.4 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_14 PF13173.6 EFX02496.1 - 8e-05 22.7 0.0 0.77 9.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EFX02496.1 - 0.00041 20.1 0.1 1.2 8.9 0.0 2.8 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EFX02496.1 - 0.0011 19.6 1.9 0.11 13.0 0.0 3.6 4 0 0 4 4 2 1 AAA domain ABC_tran PF00005.27 EFX02496.1 - 0.0014 19.1 0.7 1.1 9.7 0.0 3.4 3 0 0 3 3 3 1 ABC transporter RNA_helicase PF00910.22 EFX02496.1 - 0.0023 18.3 0.0 0.45 10.9 0.0 2.8 2 1 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 EFX02496.1 - 0.0025 17.5 0.0 0.25 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain ERM PF00769.19 EFX02496.1 - 0.0034 17.2 13.5 0.0055 16.6 13.5 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family AAA_30 PF13604.6 EFX02496.1 - 0.0045 16.7 0.1 0.41 10.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain SRP54 PF00448.22 EFX02496.1 - 0.0045 16.6 0.0 0.2 11.3 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain TsaE PF02367.17 EFX02496.1 - 0.0049 16.9 0.1 3.7 7.6 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EFX02496.1 - 0.0053 17.0 0.1 2.8 8.2 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PhoH PF02562.16 EFX02496.1 - 0.0056 16.2 0.1 0.42 10.0 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 EFX02496.1 - 0.0056 16.7 0.4 4.8 7.2 0.0 3.6 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 EFX02496.1 - 0.0056 16.6 0.1 3.1 7.7 0.0 2.7 2 1 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EFX02496.1 - 0.0056 16.3 0.0 0.36 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFX02496.1 - 0.0063 15.9 0.3 4.1 6.7 0.0 3.1 2 2 1 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFX02496.1 - 0.0074 16.5 0.7 7.2 6.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EFX02496.1 - 0.0093 16.3 0.5 0.79 10.0 0.1 3.2 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EFX02496.1 - 0.017 14.3 0.2 1.1 8.4 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF815) Erp_C PF06780.11 EFX02496.1 - 0.022 14.8 3.0 0.96 9.5 3.8 2.4 1 1 1 2 2 2 0 Erp protein C-terminus Zeta_toxin PF06414.12 EFX02496.1 - 0.039 13.2 0.0 1.2 8.3 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin DUF3829 PF12889.7 EFX02496.1 - 0.076 12.5 1.8 0.13 11.7 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) PduV-EutP PF10662.9 EFX02496.1 - 0.078 12.7 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PIF1 PF05970.14 EFX02496.1 - 0.098 11.8 0.0 2.9 7.0 0.0 2.4 3 0 0 3 3 2 0 PIF1-like helicase UvrD-helicase PF00580.21 EFX02496.1 - 0.1 12.1 3.5 0.36 10.3 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain NTPase_1 PF03266.15 EFX02496.1 - 0.11 12.4 0.0 0.8 9.6 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_29 PF13555.6 EFX02496.1 - 0.12 12.1 0.0 5.8 6.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EFX02496.1 - 0.18 11.6 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_21 PF13304.6 EFX02496.1 - 0.58 9.9 3.5 3.5 7.4 0.1 3.2 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ADIP PF11559.8 EFX02496.1 - 0.8 9.8 9.8 1.8 8.6 9.8 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding AAA_23 PF13476.6 EFX02496.1 - 0.91 10.0 17.9 1.4e+02 2.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain OEP PF02321.18 EFX02496.1 - 1.7 8.4 10.8 3.8 7.3 10.8 1.5 1 0 0 1 1 1 0 Outer membrane efflux protein Seryl_tRNA_N PF02403.22 EFX02496.1 - 2.2 8.5 11.3 2.8 8.2 9.3 2.3 2 0 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 EFX02496.1 - 9.4 5.5 8.5 16 4.7 8.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EMP24_GP25L PF01105.24 EFX02497.1 - 3.1e-48 164.1 0.0 3.6e-48 163.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Sulfate_transp PF00916.20 EFX02498.1 - 4.6e-48 163.9 5.0 7.2e-48 163.2 5.0 1.3 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 EFX02498.1 - 8.7e-15 54.6 0.0 1.7e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EFX02498.1 - 5.8e-11 42.1 0.4 1.2e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 STAS domain EAL PF00563.20 EFX02498.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 EAL domain TauE PF01925.19 EFX02498.1 - 0.19 11.3 21.0 0.31 10.6 3.2 3.2 1 1 1 3 3 3 0 Sulfite exporter TauE/SafE Glyco_hydro_3 PF00933.21 EFX02499.1 - 2e-30 106.3 0.0 2.4e-26 92.9 0.1 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFX02499.1 - 3.2e-28 99.1 0.1 7.7e-25 88.0 0.0 2.5 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFX02499.1 - 9.7e-20 70.5 0.1 2.6e-19 69.1 0.1 1.8 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.12 EFX02499.1 - 1.6e-08 34.5 0.0 3.3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 EFX02499.1 - 0.072 13.5 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 GLEYA domain SpoU_methylase PF00588.19 EFX02500.1 - 8.5e-25 87.6 0.0 1.3e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EFX02500.1 - 3.8e-07 30.3 0.1 9.2e-07 29.1 0.1 1.7 1 1 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Homeodomain PF00046.29 EFX02501.1 - 2.2e-13 49.8 0.4 2.2e-13 49.8 0.4 2.2 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 EFX02501.1 - 0.11 12.4 0.2 0.63 10.0 0.0 2.2 2 0 0 2 2 2 0 Homeobox KN domain GGACT PF06094.12 EFX02502.1 - 3.4e-17 63.2 0.0 4.7e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like DUF2655 PF10848.8 EFX02502.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2655) HD_3 PF13023.6 EFX02503.1 - 5.3e-41 140.3 0.0 6.9e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EFX02503.1 - 6.4e-06 26.0 0.0 1.1e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme EF-hand_1 PF00036.32 EFX02503.1 - 0.032 13.8 0.0 0.11 12.1 0.0 2.0 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EFX02503.1 - 0.051 14.0 0.1 0.092 13.2 0.1 1.7 1 1 0 1 1 1 0 EF-hand domain pair HD PF01966.22 EFX02503.1 - 0.054 13.7 0.0 0.14 12.4 0.0 1.8 1 1 0 1 1 1 0 HD domain Kinesin PF00225.23 EFX02504.1 - 7e-96 321.0 0.1 1.1e-95 320.4 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFX02504.1 - 1.3e-21 77.1 0.0 4e-21 75.5 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding PKcGMP_CC PF16808.5 EFX02504.1 - 0.015 15.1 0.3 0.015 15.1 0.3 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase BAR_2 PF10455.9 EFX02504.1 - 0.031 13.4 0.8 0.079 12.1 0.8 1.6 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF5520 PF17658.1 EFX02504.1 - 0.5 9.4 3.6 0.97 8.5 3.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5520) PCNA_N PF00705.18 EFX02505.1 - 4.8e-56 187.9 5.3 6.6e-56 187.5 4.7 1.5 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EFX02505.1 - 6.9e-49 165.3 0.3 2.2e-48 163.7 0.1 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EFX02505.1 - 2.1e-10 40.5 0.3 2.6e-10 40.2 0.3 1.1 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 EFX02505.1 - 4.8e-07 29.2 0.4 0.0013 17.9 0.1 2.1 2 0 0 2 2 2 2 Hus1-like protein Rad1 PF02144.16 EFX02505.1 - 1.6e-06 27.4 3.2 6.9e-05 22.0 3.2 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 DUF3074 PF11274.8 EFX02506.1 - 3.5e-45 154.2 0.0 4.5e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Dynamin_N PF00350.23 EFX02507.1 - 3.1e-20 72.9 0.0 8.2e-20 71.5 0.0 1.8 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFX02507.1 - 3.3e-09 36.4 0.0 0.0002 20.7 0.0 2.9 3 0 0 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.23 EFX02507.1 - 0.0088 16.1 0.0 0.07 13.2 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFX02507.1 - 0.036 14.3 0.1 0.38 11.0 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EFX02507.1 - 0.062 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Ribosomal_L6e PF01159.19 EFX02508.1 - 1.6e-39 134.9 1.1 2.8e-39 134.1 1.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e UCH PF00443.29 EFX02509.1 - 8.1e-27 94.3 0.2 4.9e-25 88.5 0.2 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX02509.1 - 2.2e-07 30.8 0.3 0.0028 17.3 0.1 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MFS_1 PF07690.16 EFX02510.1 - 2.4e-41 141.8 52.1 2.4e-41 141.8 52.1 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02510.1 - 2.1e-15 56.6 9.4 2.1e-15 56.6 9.4 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EFX02510.1 - 0.046 12.0 9.9 0.0065 14.8 3.9 2.4 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SPDY PF03771.16 EFX02510.1 - 0.048 13.6 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF317) adh_short PF00106.25 EFX02511.1 - 1.6e-36 125.6 0.0 2.3e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02511.1 - 6.3e-22 78.3 0.0 8.4e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02511.1 - 2.2e-07 30.9 0.0 4.2e-07 30.1 0.0 1.4 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFX02511.1 - 0.0011 18.1 0.0 0.0015 17.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EFX02511.1 - 0.017 15.4 0.0 0.045 14.0 0.0 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFX02511.1 - 0.021 14.7 0.1 0.038 13.9 0.1 1.7 1 1 0 1 1 1 0 NAD(P)H-binding Shikimate_DH PF01488.20 EFX02511.1 - 0.057 13.5 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase LytR_C PF13399.6 EFX02511.1 - 0.11 13.6 0.1 0.23 12.4 0.1 1.5 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator MinC_N PF05209.13 EFX02511.1 - 0.12 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain NAD_binding_2 PF03446.15 EFX02511.1 - 0.13 12.5 0.0 0.3 11.2 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EFX02511.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EFX02511.1 - 0.14 11.5 0.1 0.18 11.1 0.1 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase UPF0029 PF01205.19 EFX02512.1 - 1e-31 109.4 0.0 1.9e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EFX02512.1 - 0.00032 21.0 0.0 0.00063 20.0 0.0 1.5 1 1 0 1 1 1 1 RWD domain Fungal_trans PF04082.18 EFX02513.1 - 1.3e-23 83.4 0.0 2.5e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02513.1 - 3.9e-09 36.5 13.2 6.7e-09 35.7 13.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain efThoc1 PF11957.8 EFX02513.1 - 0.053 12.2 0.1 0.1 11.3 0.1 1.3 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor Folliculin PF11704.8 EFX02513.1 - 0.16 11.8 0.1 0.48 10.3 0.1 1.7 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport HMG_box_2 PF09011.10 EFX02514.1 - 4.4e-07 30.4 1.9 5.7e-05 23.6 1.1 2.7 2 0 0 2 2 2 1 HMG-box domain HMG_box PF00505.19 EFX02514.1 - 4.9e-06 26.9 1.6 4.9e-06 26.9 1.6 3.4 4 1 0 4 4 4 1 HMG (high mobility group) box HC2 PF07382.11 EFX02514.1 - 0.0044 17.1 37.7 0.0044 17.1 37.7 2.3 3 0 0 3 3 3 1 Histone H1-like nucleoprotein HC2 DUF4674 PF15719.5 EFX02514.1 - 0.24 11.4 11.2 0.53 10.3 11.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Fungal_trans_2 PF11951.8 EFX02515.1 - 9.5e-53 179.4 2.0 3.2e-52 177.6 2.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02515.1 - 4.1e-07 30.0 7.3 9e-07 28.9 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EFX02515.1 - 0.61 10.0 9.8 1.1 9.1 9.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 EFX02515.1 - 3.4 7.0 15.6 8.1 5.8 15.6 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region zf-PHD-like PF15446.6 EFX02516.1 - 8.3e-67 224.0 8.8 1.8e-66 222.9 8.8 1.7 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EFX02516.1 - 3e-47 161.0 0.0 4.8e-47 160.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX02516.1 - 4.8e-17 62.3 0.0 1.2e-16 61.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EFX02516.1 - 7.8e-08 31.8 1.0 2e-07 30.5 1.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD PF00628.29 EFX02516.1 - 0.00018 21.3 2.7 0.00018 21.3 2.7 3.3 2 1 1 3 3 3 2 PHD-finger Chromo PF00385.24 EFX02516.1 - 0.00022 21.1 0.8 0.0007 19.5 0.8 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PHD_2 PF13831.6 EFX02516.1 - 0.0098 15.4 9.0 0.024 14.2 0.6 3.4 3 0 0 3 3 3 1 PHD-finger Tudor_3 PF18115.1 EFX02516.1 - 0.014 15.2 0.0 0.043 13.6 0.0 1.8 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain AAA_25 PF13481.6 EFX02516.1 - 0.066 12.8 0.0 0.2 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain C1_1 PF00130.22 EFX02516.1 - 2.3 8.1 11.8 0.31 11.0 1.1 3.1 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GalP_UDP_tr_C PF02744.17 EFX02517.1 - 8.6e-59 198.0 0.0 1.4e-58 197.3 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.22 EFX02517.1 - 1.9e-52 178.4 0.9 1.2e-31 110.5 0.3 3.0 2 1 1 3 3 3 2 Galactose-1-phosphate uridyl transferase, N-terminal domain DUF4921 PF16268.5 EFX02517.1 - 0.011 14.5 0.1 1.5 7.6 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4921) HIT PF01230.23 EFX02517.1 - 0.036 14.8 0.0 0.087 13.6 0.0 1.7 1 0 0 1 1 1 0 HIT domain TRAP-gamma PF07074.12 EFX02517.1 - 0.12 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) HEAT_EZ PF13513.6 EFX02518.1 - 2.5e-20 72.6 9.1 4.4e-07 30.3 0.0 9.8 10 2 2 12 12 9 4 HEAT-like repeat HEAT PF02985.22 EFX02518.1 - 1.9e-18 64.9 3.1 0.0087 16.2 0.0 9.4 11 0 0 11 11 8 3 HEAT repeat HEAT_2 PF13646.6 EFX02518.1 - 2.3e-15 56.8 16.3 0.011 16.1 0.1 10.0 5 3 6 11 11 11 4 HEAT repeats Vac14_Fab1_bd PF12755.7 EFX02518.1 - 5.8e-11 42.8 0.0 0.025 15.2 0.0 5.0 3 1 1 4 4 3 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EFX02518.1 - 1.1e-09 37.4 0.0 0.0043 15.7 0.0 5.0 3 2 1 4 4 4 3 Adaptin N terminal region IBN_N PF03810.19 EFX02518.1 - 5.1e-08 32.7 0.7 4.2e-05 23.4 0.0 3.7 2 1 0 2 2 2 1 Importin-beta N-terminal domain Cnd1 PF12717.7 EFX02518.1 - 3.1e-07 30.6 0.1 0.0025 17.9 0.0 4.1 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 EFX02518.1 - 0.00012 21.3 4.0 0.09 11.9 0.1 4.0 4 1 0 4 4 4 2 Interferon-related developmental regulator (IFRD) Arm PF00514.23 EFX02518.1 - 0.00018 21.4 3.3 15 5.8 0.0 6.4 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat RIX1 PF08167.12 EFX02518.1 - 0.0002 21.2 0.0 0.37 10.5 0.0 4.0 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 EFX02518.1 - 0.0003 20.9 3.1 0.25 11.5 0.0 4.5 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EFX02518.1 - 0.00044 19.9 0.0 0.94 9.0 0.0 3.6 3 1 1 4 4 4 2 CLASP N terminal MMS19_C PF12460.8 EFX02518.1 - 0.0033 16.6 4.5 1.2 8.2 0.0 3.9 3 1 1 4 4 4 2 RNAPII transcription regulator C-terminal ParcG PF10274.9 EFX02518.1 - 0.0033 17.6 0.2 0.53 10.4 0.0 3.6 4 0 0 4 4 4 1 Parkin co-regulated protein DUF3437 PF11919.8 EFX02518.1 - 0.08 12.9 0.2 17 5.4 0.0 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3437) TIP120 PF08623.10 EFX02518.1 - 0.13 12.0 1.3 0.86 9.4 0.0 3.0 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) WD40 PF00400.32 EFX02519.1 - 1.5e-41 139.6 19.1 2.8e-06 28.0 0.0 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02519.1 - 3.6e-09 36.8 1.2 2.3 8.6 0.0 6.0 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX02519.1 - 0.0043 15.8 5.8 3.7 6.1 0.1 5.2 3 1 3 6 6 6 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EFX02519.1 - 0.055 13.0 0.6 8 6.0 0.0 2.8 2 1 1 3 3 3 0 PQQ-like domain 3Beta_HSD PF01073.19 EFX02520.1 - 6.8e-63 212.3 0.0 8.1e-63 212.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFX02520.1 - 5.7e-33 114.4 0.2 8.3e-33 113.8 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX02520.1 - 4.6e-21 75.6 0.0 1e-16 61.3 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFX02520.1 - 4.1e-12 45.8 0.2 5.4e-12 45.4 0.2 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EFX02520.1 - 1.6e-11 43.9 0.1 1.7e-09 37.3 0.1 2.2 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 EFX02520.1 - 3.8e-10 39.9 0.1 5.9e-10 39.3 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFX02520.1 - 2.6e-09 36.6 0.0 2.6e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EFX02520.1 - 3.3e-05 23.6 0.0 5.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EFX02520.1 - 0.00044 20.5 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFX02520.1 - 0.00074 19.5 0.1 0.0021 18.0 0.1 1.7 1 1 0 1 1 1 1 KR domain TrkA_N PF02254.18 EFX02520.1 - 0.013 15.7 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_3 PF03447.16 EFX02520.1 - 0.037 14.7 0.0 0.081 13.6 0.0 1.6 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DUF3798 PF12683.7 EFX02520.1 - 0.093 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) Proteasome PF00227.26 EFX02521.1 - 2.3e-60 203.4 0.1 2.8e-60 203.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFX02521.1 - 3.2e-13 49.1 0.1 8.7e-13 47.7 0.1 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 EFX02521.1 - 0.021 14.9 0.4 0.06 13.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 EFX02521.1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Ribosomal_L29 PF00831.23 EFX02522.1 - 4.3e-18 65.0 6.2 1.7e-17 63.1 1.4 2.3 2 0 0 2 2 2 2 Ribosomal L29 protein Ribosomal_S9 PF00380.19 EFX02522.1 - 0.019 15.5 1.3 0.021 15.4 1.3 1.2 1 0 0 1 1 1 0 Ribosomal protein S9/S16 Vps54_N PF10475.9 EFX02522.1 - 0.14 11.4 2.9 0.16 11.2 2.9 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex RGS PF00615.19 EFX02523.1 - 3.5e-05 24.1 0.0 0.00017 21.9 0.0 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Sugar_tr PF00083.24 EFX02524.1 - 7.7e-76 255.8 21.4 9.1e-76 255.5 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX02524.1 - 6.7e-13 48.3 42.9 1.9e-12 46.8 39.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2574 PF10836.8 EFX02524.1 - 0.13 12.2 0.5 0.43 10.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2574) EBP PF05241.12 EFX02524.1 - 1 8.8 6.9 1 8.8 1.1 2.5 2 0 0 2 2 2 0 Emopamil binding protein Sugar_tr PF00083.24 EFX02525.1 - 1.7e-51 175.5 5.0 5.6e-51 173.8 1.6 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFX02525.1 - 2.4e-16 59.6 14.4 1.5e-13 50.4 8.5 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily LUC7 PF03194.15 EFX02526.1 - 5.2e-68 229.4 0.2 6.4e-68 229.1 0.2 1.0 1 0 0 1 1 1 1 LUC7 N_terminus DUF1241 PF06840.11 EFX02526.1 - 0.012 15.2 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Spc7 PF08317.11 EFX02526.1 - 0.015 14.2 0.1 0.028 13.3 0.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein MCPsignal PF00015.21 EFX02526.1 - 0.023 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain RSS_P20 PF11757.8 EFX02526.1 - 0.046 14.2 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain DASH_Duo1 PF08651.10 EFX02526.1 - 0.098 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Duo1 2-oxoacid_dh PF00198.23 EFX02527.1 - 1.9e-69 233.7 0.0 2.9e-69 233.1 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFX02527.1 - 2.2e-18 65.8 0.1 4.6e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EFX02527.1 - 6e-13 48.9 0.4 4.6e-12 46.1 0.0 2.6 2 0 0 2 2 2 1 e3 binding domain NTP_transferase PF00483.23 EFX02528.1 - 2.1e-30 106.1 0.0 3.2e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EFX02528.1 - 5.9e-10 38.5 5.7 1.8e-06 27.4 0.0 3.6 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFX02528.1 - 4.8e-06 27.0 0.0 7.3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EFX02528.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.6 EFX02528.1 - 0.13 12.0 0.2 7.8 6.3 0.0 3.4 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase CRCB PF02537.15 EFX02529.1 - 1.7e-34 118.0 14.6 1.4e-18 67.0 10.0 2.6 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Arrestin_N PF00339.29 EFX02529.1 - 0.052 13.6 0.2 2.4 8.2 0.0 2.6 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain CAP_N PF01213.19 EFX02529.1 - 5.3 6.4 4.8 2 7.8 1.8 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Plasmodium_Vir PF05795.11 EFX02530.1 - 0.47 9.8 1.4 0.9 8.9 1.4 1.5 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NYN PF01936.18 EFX02531.1 - 1.4e-34 119.7 0.0 2.1e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 NYN domain OST-HTH PF12872.7 EFX02531.1 - 3.1e-12 46.1 0.0 6.2e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 OST-HTH/LOTUS domain PIN7 PF18475.1 EFX02531.1 - 0.034 14.8 0.0 0.12 13.0 0.0 2.0 2 1 0 2 2 2 0 PIN domain DUF3405 PF11885.8 EFX02532.1 - 1.2e-229 763.2 0.0 1.5e-229 762.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) TFIIF_alpha PF05793.12 EFX02532.1 - 0.17 10.5 6.0 0.25 9.9 6.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CENP-B_dimeris PF09026.10 EFX02532.1 - 1.8 9.0 7.3 4.5 7.7 7.3 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_M41 PF01434.18 EFX02533.1 - 5.2e-67 225.4 0.0 8.1e-67 224.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFX02533.1 - 2.2e-42 144.6 0.0 4.1e-42 143.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.15 EFX02533.1 - 4.2e-11 43.1 0.0 8.8e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_lid_3 PF17862.1 EFX02533.1 - 2.5e-10 40.0 0.2 5.8e-10 38.8 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFX02533.1 - 0.0037 17.2 0.0 0.014 15.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFX02533.1 - 0.0053 16.0 0.1 0.01 15.1 0.1 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EFX02533.1 - 0.018 14.8 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFX02533.1 - 0.018 15.5 0.2 0.44 10.9 0.1 2.8 1 1 1 2 2 2 0 AAA ATPase domain AAA_2 PF07724.14 EFX02533.1 - 0.024 14.8 0.0 0.068 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFX02533.1 - 0.043 14.1 0.3 1.6 9.0 0.1 2.8 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EFX02533.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Nucleoporin_N PF08801.11 EFX02534.1 - 9e-94 314.7 0.0 1.4e-93 314.0 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EFX02534.1 - 3.5e-54 184.6 0.0 1.1e-52 179.7 0.0 2.2 1 1 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Apo-CIII PF05778.12 EFX02534.1 - 0.073 12.7 0.2 0.51 10.0 0.0 2.3 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) CENP-Q PF13094.6 EFX02535.1 - 0.016 15.4 3.3 0.035 14.3 3.3 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MPS2 PF17060.5 EFX02535.1 - 0.034 13.4 0.1 0.048 12.9 0.1 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 TLP-20 PF06088.11 EFX02535.1 - 0.67 9.8 4.4 0.29 11.0 0.3 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) HTH_32 PF13565.6 EFX02536.1 - 0.071 13.7 1.1 0.53 10.9 1.5 2.2 2 0 0 2 2 2 0 Homeodomain-like domain p450 PF00067.22 EFX02538.1 - 9e-15 54.4 0.0 3.2e-14 52.5 0.0 1.8 1 1 1 2 2 2 1 Cytochrome P450 DUF3818 PF12825.7 EFX02539.1 - 1e-124 416.0 4.2 1.5e-124 415.4 4.2 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) FAD_binding_2 PF00890.24 EFX02539.1 - 1.1e-123 413.4 2.2 1.6e-123 412.9 2.2 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EFX02539.1 - 2.1e-43 147.4 0.1 4.1e-43 146.4 0.1 1.5 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term PXB PF12828.7 EFX02539.1 - 3e-38 130.8 0.9 2e-37 128.1 0.7 2.2 2 0 0 2 2 2 1 PX-associated PX PF00787.24 EFX02539.1 - 9.4e-10 38.5 0.1 9.3e-09 35.3 0.0 2.7 2 1 0 2 2 2 1 PX domain GIDA PF01134.22 EFX02539.1 - 0.0017 17.5 0.4 0.38 9.8 1.1 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EFX02539.1 - 0.0029 16.9 0.9 0.18 11.0 0.3 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase YL1 PF05764.13 EFX02539.1 - 0.0079 16.3 0.3 0.019 15.1 0.3 1.6 1 0 0 1 1 1 1 YL1 nuclear protein FAD_binding_3 PF01494.19 EFX02539.1 - 0.014 14.7 0.1 0.024 13.9 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EFX02539.1 - 0.02 14.2 0.1 0.19 11.0 0.0 2.2 2 0 0 2 2 2 0 Thi4 family Cu_amine_oxid PF01179.20 EFX02540.1 - 5.8e-158 526.1 0.0 7e-158 525.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EFX02540.1 - 4.4e-23 81.6 0.4 1.6e-22 79.8 0.2 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EFX02540.1 - 2e-14 53.6 0.0 3.2e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Glyco_hydro_127 PF07944.12 EFX02541.1 - 7.8e-90 301.8 0.1 1.1e-89 301.3 0.1 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 zf-H2C2_2 PF13465.6 EFX02541.1 - 0.0059 17.0 0.7 0.017 15.5 0.7 1.9 1 0 0 1 1 1 1 Zinc-finger double domain zf-C2H2 PF00096.26 EFX02541.1 - 0.016 15.6 8.4 0.74 10.4 1.4 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type AICARFT_IMPCHas PF01808.18 EFX02542.1 - 6e-91 305.0 0.0 8.1e-91 304.5 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EFX02542.1 - 6.9e-23 80.7 0.0 1.3e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain DUF1455 PF07306.11 EFX02543.1 - 0.048 13.6 0.6 0.075 13.0 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) Glyco_hydro_8 PF01270.17 EFX02544.1 - 0.11 11.4 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 8 Anp1 PF03452.14 EFX02545.1 - 4.8e-104 347.5 0.0 5.6e-104 347.2 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EFX02545.1 - 0.00041 20.2 0.0 0.00069 19.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 CBP_BcsO PF17037.5 EFX02545.1 - 0.052 13.7 3.1 0.091 12.9 3.1 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Peptidase_M49 PF03571.15 EFX02546.1 - 2.2e-209 696.4 0.0 7e-182 605.6 0.0 2.0 1 1 1 2 2 2 2 Peptidase family M49 MARVEL PF01284.23 EFX02547.1 - 1.2e-07 31.8 8.6 1.2e-07 31.8 8.6 1.5 1 1 0 1 1 1 1 Membrane-associating domain DUF4281 PF14108.6 EFX02547.1 - 0.0072 16.7 0.8 0.014 15.7 0.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4281) SirB PF04247.12 EFX02548.1 - 0.018 15.1 0.2 0.037 14.1 0.2 1.5 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB Fungal_trans PF04082.18 EFX02549.1 - 3.6e-07 29.5 0.0 6.3e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02549.1 - 0.0081 16.3 9.1 0.0081 16.3 9.1 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rab5ip PF07019.12 EFX02551.1 - 1.3e-27 96.2 8.8 1.7e-27 95.8 8.8 1.2 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) CorA PF01544.18 EFX02552.1 - 1.8e-05 24.2 2.3 1.8e-05 24.2 2.3 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SPOC PF07744.13 EFX02553.1 - 1.4e-25 89.9 0.0 2.3e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 EFX02553.1 - 2.6e-18 66.6 0.0 5.9e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EFX02553.1 - 6.7e-10 38.7 6.9 1.4e-09 37.7 6.9 1.6 1 0 0 1 1 1 1 PHD-finger Rubella_Capsid PF05750.11 EFX02553.1 - 3.2 7.3 9.3 0.085 12.5 1.3 2.4 3 1 1 4 4 4 0 Rubella capsid protein Stk19 PF10494.9 EFX02554.1 - 4.4e-55 187.0 0.0 6e-55 186.6 0.0 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Loricrin PF15847.5 EFX02554.1 - 0.87 8.6 15.5 0.084 11.9 10.7 1.8 2 0 0 2 2 2 0 Major keratinocyte cell envelope protein Proteasome PF00227.26 EFX02555.1 - 1.9e-45 154.7 0.1 2.2e-45 154.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Glyco_hydro_129 PF11308.8 EFX02555.1 - 0.086 12.0 0.0 0.16 11.1 0.0 1.4 2 0 0 2 2 2 0 Glycosyl hydrolases related to GH101 family, GH129 DEAD PF00270.29 EFX02556.1 - 2.7e-48 164.1 0.0 3.2e-47 160.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX02556.1 - 1.3e-27 96.3 0.0 3.5e-27 94.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX02556.1 - 0.0046 17.0 0.0 0.0098 15.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PCC_BT PF18140.1 EFX02556.1 - 0.15 12.4 1.4 0.4 11.0 1.4 1.7 1 0 0 1 1 1 0 Propionyl-coenzyme A carboxylase BT domain Peptidase_M22 PF00814.25 EFX02557.1 - 9.3e-48 163.3 0.0 3.4e-45 154.9 0.0 2.8 1 1 0 1 1 1 1 Glycoprotease family Transp_cyt_pur PF02133.15 EFX02558.1 - 1.1e-24 87.0 40.9 1.8e-24 86.3 40.9 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Meckelin PF09773.9 EFX02558.1 - 0.7 7.9 2.1 0.99 7.4 2.1 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) FliT PF05400.13 EFX02559.1 - 0.036 14.9 0.0 0.23 12.3 0.0 2.1 2 0 0 2 2 2 0 Flagellar protein FliT GMC_oxred_N PF00732.19 EFX02560.1 - 5.2e-14 52.3 0.0 1.1e-13 51.3 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX02560.1 - 1.5e-07 32.0 0.0 3.1e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase Pyr_redox_3 PF13738.6 EFX02560.1 - 4.9e-07 29.3 2.1 0.018 14.3 0.8 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX02560.1 - 2.2e-06 27.0 0.1 9.1e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX02560.1 - 2.7e-05 23.6 0.0 0.00069 18.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX02560.1 - 4.6e-05 22.9 0.5 8e-05 22.2 0.2 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFX02560.1 - 5.9e-05 22.0 0.2 0.0017 17.1 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EFX02560.1 - 8.6e-05 21.8 0.3 0.002 17.3 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.24 EFX02560.1 - 0.00036 20.2 2.3 0.1 12.2 0.0 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFX02560.1 - 0.0072 15.4 0.0 0.021 13.9 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EFX02560.1 - 0.031 13.5 0.3 0.045 13.0 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EFX02560.1 - 0.031 13.5 0.8 0.068 12.4 0.0 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 EFX02560.1 - 0.053 14.1 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX02560.1 - 0.074 13.3 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_hydro_76 PF03663.14 EFX02561.1 - 6.9e-156 519.4 27.9 8.1e-156 519.1 27.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 UQ_con PF00179.26 EFX02562.1 - 4.5e-28 97.6 0.0 5.3e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ATP-synt_10 PF05176.14 EFX02563.1 - 7.5e-35 120.4 0.0 1e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein Mito_carr PF00153.27 EFX02565.1 - 2.9e-37 126.5 5.4 9.1e-16 57.6 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_A4 PF01828.17 EFX02566.1 - 2.7e-79 265.5 10.7 3.3e-79 265.2 10.7 1.1 1 0 0 1 1 1 1 Peptidase A4 family Fungal_trans PF04082.18 EFX02567.1 - 1.4e-08 34.1 0.1 1.9e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain UPF0113_N PF17833.1 EFX02568.1 - 7.8e-24 84.1 0.0 1e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EFX02568.1 - 1.3e-23 83.1 0.0 2.1e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EFX02568.1 - 0.016 15.2 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 PUA domain Glyco_transf_34 PF05637.12 EFX02569.1 - 8e-67 225.4 1.1 1.1e-66 225.0 1.1 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 EFX02569.1 - 0.051 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Gly_transf_sug PF04488.15 EFX02570.1 - 1.1e-11 45.2 0.0 3.6e-11 43.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Acyl_transf_3 PF01757.22 EFX02571.1 - 3.6e-16 59.2 26.2 7e-16 58.2 26.3 1.5 1 1 0 1 1 1 1 Acyltransferase family Colicin_im PF03857.13 EFX02571.1 - 0.44 10.5 2.7 0.29 11.1 0.3 1.9 2 0 0 2 2 2 0 Colicin immunity protein PI3_PI4_kinase PF00454.27 EFX02572.1 - 3e-33 115.7 0.0 1.5e-32 113.4 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EFX02572.1 - 9.1e-18 64.0 0.0 2.3e-17 62.7 0.0 1.7 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 EFX02572.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PLA2_B PF01735.18 EFX02573.1 - 9.6e-23 80.3 0.0 2.1e-22 79.2 0.0 1.5 1 1 0 1 1 1 1 Lysophospholipase catalytic domain PAP_PilO PF06864.12 EFX02573.1 - 0.0035 16.2 1.2 0.0035 16.2 1.2 1.6 2 0 0 2 2 2 1 Pilin accessory protein (PilO) DUF1990 PF09348.10 EFX02573.1 - 0.18 11.8 1.5 0.47 10.5 0.3 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1990) DEAD PF00270.29 EFX02574.1 - 1.3e-47 161.9 0.0 4e-47 160.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX02574.1 - 4.1e-32 110.8 0.0 9.5e-32 109.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX02574.1 - 0.098 12.6 0.0 0.3 11.1 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFX02574.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit HORMA PF02301.18 EFX02575.1 - 6.8e-34 117.3 0.0 7.9e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 EFX02575.1 - 0.0022 18.0 0.5 0.012 15.5 0.5 2.1 1 1 0 1 1 1 1 Autophagy-related protein 101 DUF2660 PF10859.8 EFX02575.1 - 0.0076 16.7 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2660) DUF4484 PF14831.6 EFX02575.1 - 0.0095 16.0 0.4 0.013 15.6 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) DUF4148 PF13663.6 EFX02575.1 - 0.36 11.0 2.9 0.62 10.3 2.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Helicase_C PF00271.31 EFX02577.1 - 6.8e-23 81.1 0.1 1.7e-22 79.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX02577.1 - 7.2e-23 81.5 0.1 4.9e-22 78.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFX02577.1 - 1.3e-16 60.8 0.0 9.9e-16 58.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EFX02577.1 - 0.0018 18.0 0.0 0.0047 16.6 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 EFX02577.1 - 0.027 14.7 0.0 0.091 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain SAGA-Tad1 PF12767.7 EFX02578.1 - 4.1e-59 200.2 0.0 5.5e-59 199.8 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit C2 PF00168.30 EFX02579.1 - 2.4e-79 262.3 0.0 5.4e-22 78.0 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 EFX02579.1 - 1.5e-05 24.5 0.0 4.2e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain MLVIN_C PF18697.1 EFX02579.1 - 0.12 12.4 0.1 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain EthD PF07110.11 EFX02581.1 - 2.1e-20 73.6 0.1 2.4e-20 73.5 0.1 1.0 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EFX02581.1 - 7.5e-05 23.2 0.1 9.4e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase WD40 PF00400.32 EFX02582.1 - 2.5e-30 104.0 6.8 1.7e-06 28.6 0.8 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02582.1 - 2.4e-08 34.1 0.0 0.16 12.3 0.0 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX02582.1 - 2.2e-05 23.4 6.8 0.24 10.0 0.1 4.9 3 2 2 5 5 5 4 Nucleoporin Nup120/160 Methyltransf_11 PF08241.12 EFX02584.1 - 6.4e-18 65.2 0.0 1.5e-15 57.6 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX02584.1 - 7.4e-18 64.9 0.0 1e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02584.1 - 1.6e-15 57.5 0.0 7e-14 52.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02584.1 - 3.6e-14 53.3 0.0 5.8e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02584.1 - 4.4e-11 42.8 0.0 8e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX02584.1 - 2.2e-05 24.1 0.0 4.9e-05 22.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 EFX02584.1 - 0.0037 16.6 0.0 0.54 9.5 0.0 2.1 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EFX02584.1 - 0.0041 16.5 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EFX02584.1 - 0.07 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EFX02584.1 - 0.09 12.4 0.0 0.54 9.8 0.0 1.9 2 0 0 2 2 2 0 Nodulation protein S (NodS) PCMT PF01135.19 EFX02584.1 - 0.19 11.4 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PI-PLC-X PF00388.19 EFX02585.1 - 8.6e-05 22.2 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain adh_short PF00106.25 EFX02586.1 - 9.6e-27 93.7 2.6 1.5e-26 93.1 2.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02586.1 - 3.7e-14 52.9 3.7 4.9e-14 52.5 3.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFX02586.1 - 0.00027 20.5 0.3 0.0016 17.9 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFX02586.1 - 0.00044 19.9 0.5 0.00044 19.9 0.5 2.1 3 0 0 3 3 3 1 NmrA-like family KR PF08659.10 EFX02586.1 - 0.00072 19.5 0.4 0.0014 18.6 0.4 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFX02586.1 - 0.0016 18.4 3.9 0.003 17.5 3.9 1.7 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFX02586.1 - 0.0084 15.5 0.0 3 7.1 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase SpoVIF PF14069.6 EFX02586.1 - 0.17 11.7 2.5 0.43 10.4 0.0 2.7 4 0 0 4 4 4 0 Stage VI sporulation protein F Glyco_transf_22 PF03901.17 EFX02587.1 - 1.7e-68 231.8 18.0 2e-68 231.5 18.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family NPDC1 PF06809.11 EFX02587.1 - 0.059 12.4 1.0 1.5 7.8 0.1 2.3 2 0 0 2 2 2 0 Neural proliferation differentiation control-1 protein (NPDC1) AIM3 PF17096.5 EFX02588.1 - 0.0039 18.1 1.3 0.0039 18.1 1.3 4.8 4 1 1 5 5 5 1 Altered inheritance of mitochondria protein 3 Ysc84 PF04366.12 EFX02589.1 - 2.1e-29 101.9 0.0 4e-29 100.9 0.0 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator NOG1_N PF17835.1 EFX02591.1 - 1e-46 158.8 0.3 2.6e-46 157.5 0.0 1.9 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 EFX02591.1 - 7.2e-23 80.1 0.0 1.7e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 EFX02591.1 - 1.1e-21 76.6 0.5 2.8e-21 75.3 0.5 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 EFX02591.1 - 3.8e-12 46.3 0.0 1e-11 44.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX02591.1 - 0.00018 21.1 0.0 0.00035 20.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Glyco_tranf_2_2 PF10111.9 EFX02591.1 - 0.043 13.3 0.6 0.33 10.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Dynamin_N PF00350.23 EFX02591.1 - 0.046 13.8 0.3 10 6.1 0.1 2.7 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.6 EFX02591.1 - 0.052 13.9 0.0 1.4 9.2 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain DNA_pol_phi PF04931.13 EFX02591.1 - 1.5 6.8 13.0 2.2 6.3 13.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi adh_short PF00106.25 EFX02592.1 - 1.1e-29 103.3 0.0 1.3e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02592.1 - 8.8e-19 68.0 0.0 1.1e-18 67.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFX02592.1 - 5.4e-06 26.1 0.0 6.8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EFX02592.1 - 9.9e-06 25.6 0.1 1.6e-05 24.9 0.1 1.5 1 1 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 EFX02592.1 - 0.0012 18.2 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFX02592.1 - 0.0014 19.2 1.1 0.0024 18.4 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DUF1776 PF08643.10 EFX02592.1 - 0.027 13.9 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 EFX02592.1 - 0.049 12.7 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.13 EFX02592.1 - 0.064 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Voltage_CLC PF00654.20 EFX02593.1 - 7.9e-88 295.1 28.6 1.2e-87 294.4 28.6 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel zf-GRF PF06839.12 EFX02594.1 - 8.7e-10 38.5 2.4 1.5e-09 37.7 2.4 1.4 1 0 0 1 1 1 1 GRF zinc finger Use1 PF09753.9 EFX02595.1 - 5.3e-10 39.4 2.0 2.1e-09 37.5 0.0 2.0 1 1 0 2 2 2 1 Membrane fusion protein Use1 Zfx_Zfy_act PF04704.13 EFX02595.1 - 0.057 12.5 0.1 0.088 11.9 0.1 1.2 1 0 0 1 1 1 0 Zfx / Zfy transcription activation region DUF572 PF04502.13 EFX02595.1 - 0.45 10.1 4.8 0.48 10.0 4.1 1.2 1 1 0 1 1 1 0 Family of unknown function (DUF572) DUF5525 PF17663.1 EFX02595.1 - 0.52 8.3 3.4 0.38 8.8 1.8 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5525) Herpes_UL25 PF01499.16 EFX02595.1 - 0.53 8.7 3.5 0.74 8.3 3.5 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family DUF349 PF03993.12 EFX02595.1 - 0.61 10.4 4.0 0.39 11.1 1.2 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Med17 PF10156.9 EFX02596.1 - 3.4e-69 233.8 0.0 4.9e-43 147.5 0.0 2.1 2 0 0 2 2 2 2 Subunit 17 of Mediator complex DASH_Spc34 PF08657.10 EFX02596.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Mto2_bdg PF12808.7 EFX02596.1 - 1.3 9.4 8.2 0.36 11.2 1.1 2.9 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Fungal_trans PF04082.18 EFX02598.1 - 2e-13 50.0 0.0 1.5e-12 47.2 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02598.1 - 3.3e-07 30.3 7.2 3.3e-07 30.3 7.2 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ad_cyc_g-alpha PF08509.11 EFX02598.1 - 0.15 11.8 1.3 0.27 11.0 0.1 2.1 2 0 0 2 2 2 0 Adenylate cyclase G-alpha binding domain UCH PF00443.29 EFX02601.1 - 1.3e-42 146.1 0.0 3.5e-39 134.8 0.0 2.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX02601.1 - 1.7e-08 34.5 0.0 7.8e-07 29.0 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PDT PF00800.18 EFX02602.1 - 2.6e-52 177.3 0.0 3.5e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EFX02602.1 - 0.00068 19.4 0.0 0.0025 17.5 0.0 2.1 2 1 0 2 2 2 1 ACT domain GDP_Man_Dehyd PF16363.5 EFX02603.1 - 5.9e-69 233.0 0.0 6.9e-69 232.8 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFX02603.1 - 4.8e-57 193.2 0.0 6.1e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFX02603.1 - 8.7e-23 80.9 0.0 8.4e-22 77.6 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFX02603.1 - 5.5e-20 71.5 0.0 6.9e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFX02603.1 - 1.6e-18 66.8 0.1 2.9e-17 62.7 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EFX02603.1 - 5.6e-17 61.8 0.0 7.2e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFX02603.1 - 5.7e-08 32.9 0.0 4.4e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EFX02603.1 - 0.024 14.1 0.0 1.8 7.9 0.1 2.2 2 0 0 2 2 2 0 short chain dehydrogenase Lipase3_N PF03893.16 EFX02603.1 - 0.12 12.4 0.0 10 6.2 0.0 2.6 2 0 0 2 2 2 0 Lipase 3 N-terminal region Fungal_trans PF04082.18 EFX02604.1 - 6.2e-19 68.1 1.7 3.1e-16 59.2 0.8 2.5 1 1 1 2 2 2 2 Fungal specific transcription factor domain Lar_N PF09861.9 EFX02604.1 - 0.0028 16.9 0.0 0.0054 15.9 0.0 1.4 1 0 0 1 1 1 1 Lactate racemase N-terminal domain SDA1 PF05285.12 EFX02604.1 - 0.026 13.9 4.5 0.045 13.2 4.5 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EFX02604.1 - 0.099 10.8 6.1 0.17 10.1 6.1 1.3 1 0 0 1 1 1 0 Nop14-like family Zn_clus PF00172.18 EFX02604.1 - 0.37 11.0 16.6 0.74 10.0 16.6 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_pol_phi PF04931.13 EFX02604.1 - 0.94 7.5 17.4 1.4 6.9 17.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi PAT1 PF09770.9 EFX02604.1 - 3.3 5.9 13.6 6.1 5.0 13.6 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 YL1 PF05764.13 EFX02604.1 - 6.4 6.8 13.4 0.61 10.2 6.4 2.1 2 0 0 2 2 2 0 YL1 nuclear protein Lin-8 PF03353.15 EFX02604.1 - 7.9 5.9 15.2 19 4.7 15.2 1.6 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 EFX02604.1 - 8.8 3.3 10.9 15 2.5 10.9 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Vps54 PF07928.12 EFX02605.1 - 5.2e-40 137.0 0.2 2.4e-39 134.8 0.0 2.2 2 0 0 2 2 2 1 Vps54-like protein DUF2451 PF10474.9 EFX02605.1 - 3.2e-07 30.4 0.0 8.7e-06 25.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EFX02605.1 - 1.4e-05 24.6 0.1 3.4e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF3510 PF12022.8 EFX02605.1 - 0.0033 17.8 0.2 2.3 8.6 0.0 3.4 3 1 0 3 3 3 2 Domain of unknown function (DUF3510) Glyco_hydro_17 PF00332.18 EFX02606.1 - 2.4e-08 34.0 0.2 4e-08 33.2 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 NAD_kinase PF01513.21 EFX02607.1 - 6.1e-80 268.5 0.0 1.3e-79 267.5 0.0 1.5 2 0 0 2 2 2 1 ATP-NAD kinase DUF2034 PF10356.9 EFX02608.1 - 1.8e-26 92.7 0.0 2.3e-12 46.7 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EFX02608.1 - 3.1e-06 27.2 0.0 5.2e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease Y_phosphatase3 PF13350.6 EFX02609.1 - 2.8e-55 187.8 0.0 3.5e-55 187.5 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFX02609.1 - 0.06 12.9 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ACT_6 PF13740.6 EFX02609.1 - 0.11 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 ACT domain ArfGap PF01412.18 EFX02610.1 - 3.5e-38 130.3 0.3 7.4e-38 129.2 0.3 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PIG-X PF08320.12 EFX02612.1 - 1.3e-69 234.3 0.0 2e-69 233.7 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 RCDG1 PF15725.5 EFX02612.1 - 0.083 13.3 2.6 15 6.1 0.2 3.3 3 0 0 3 3 3 0 Renal cancer differentiation gene 1 protein Sec1 PF00995.23 EFX02614.1 - 3e-120 403.2 0.0 3.4e-120 403.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sybindin PF04099.12 EFX02615.1 - 8.9e-27 93.8 0.0 1.1e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFX02615.1 - 0.099 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region G10 PF01125.17 EFX02616.1 - 2.4e-64 215.5 4.5 2.7e-64 215.4 4.5 1.0 1 0 0 1 1 1 1 G10 protein SAT PF16073.5 EFX02617.1 - 2.6e-77 259.8 0.3 2.6e-77 259.8 0.3 2.1 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 EFX02617.1 - 3.1e-75 253.0 0.0 6.2e-75 252.0 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFX02617.1 - 2e-46 159.0 0.2 6.3e-46 157.3 0.2 1.9 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFX02617.1 - 1.2e-35 122.0 0.4 3.1e-35 120.8 0.4 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFX02617.1 - 5.2e-26 90.8 4.4 4.1e-12 46.3 0.3 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.20 EFX02617.1 - 3e-19 70.1 1.9 7.4e-19 68.8 0.0 2.6 3 0 0 3 3 3 1 Thioesterase domain PS-DH PF14765.6 EFX02617.1 - 8.3e-18 64.6 0.0 1.5e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EFX02617.1 - 0.00016 21.1 1.3 0.00086 18.7 0.1 2.6 3 0 0 3 3 3 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EFX02617.1 - 0.00083 19.8 0.0 0.002 18.6 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EFX02617.1 - 0.0016 19.0 0.8 0.0016 19.0 0.8 3.7 3 1 0 3 3 3 1 Alpha/beta hydrolase family DUF3701 PF12482.8 EFX02617.1 - 0.031 14.3 0.1 3.5 7.8 0.0 2.7 2 0 0 2 2 2 0 Phage integrase protein Methyltransf_23 PF13489.6 EFX02618.1 - 4.6e-21 75.4 0.0 6.1e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02618.1 - 4.7e-11 43.2 0.0 1.1e-10 42.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02618.1 - 1.6e-09 38.4 0.0 9.5e-09 35.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02618.1 - 1.1e-08 35.1 0.0 1.6e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02618.1 - 5.8e-08 33.3 0.0 1.2e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX02618.1 - 0.0015 18.1 0.0 0.0061 16.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EFX02618.1 - 0.002 17.9 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFX02618.1 - 0.007 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EFX02618.1 - 0.029 14.5 0.0 0.13 12.4 0.0 2.1 3 0 0 3 3 3 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EFX02618.1 - 0.064 12.5 0.0 0.33 10.2 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EFX02618.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Aldo_ket_red PF00248.21 EFX02619.1 - 1.7e-71 240.8 0.0 2.1e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SUIM_assoc PF16619.5 EFX02620.1 - 1.7e-08 34.4 9.2 0.00099 19.1 9.2 3.2 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 bZIP_1 PF00170.21 EFX02620.1 - 1.4e-07 31.5 8.4 1.4e-07 31.5 8.4 2.7 2 1 0 2 2 2 1 bZIP transcription factor LMBR1 PF04791.16 EFX02620.1 - 0.26 10.2 3.0 0.34 9.8 3.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DcuA_DcuB PF03605.14 EFX02620.1 - 1.8 7.4 5.2 3.7 6.3 5.2 1.4 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF4259 PF14078.6 EFX02620.1 - 2.3 9.0 7.6 0.84 10.4 4.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) ABC2_membrane_3 PF12698.7 EFX02620.1 - 2.4 7.2 5.6 4 6.5 5.6 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein V_ATPase_I PF01496.19 EFX02620.1 - 4.7 5.0 10.1 6.9 4.5 10.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_Maf PF03131.17 EFX02620.1 - 4.8 7.8 32.0 1.4 9.5 5.2 3.3 3 0 0 3 3 3 0 bZIP Maf transcription factor DUF4407 PF14362.6 EFX02620.1 - 5.1 6.4 23.4 9.4 5.5 23.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 EFX02620.1 - 9.4 6.1 54.2 10 6.0 3.7 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Fungal_trans PF04082.18 EFX02621.1 - 3.1e-19 69.1 1.2 5.4e-19 68.3 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02621.1 - 0.0026 17.8 11.1 0.0069 16.5 11.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clr2 PF10383.9 EFX02622.1 - 1.1e-26 94.4 0.1 3.1e-26 92.9 0.0 1.9 2 0 0 2 2 2 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 EFX02622.1 - 1.9e-14 54.2 0.0 3.9e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 Med3 PF11593.8 EFX02622.1 - 0.008 15.4 0.9 0.008 15.4 0.9 3.2 4 0 0 4 4 4 1 Mediator complex subunit 3 fungal Pkinase PF00069.25 EFX02623.1 - 2e-60 204.4 0.0 1.4e-59 201.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02623.1 - 2.6e-28 99.0 0.1 6.6e-20 71.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EFX02623.1 - 0.00065 20.3 0.5 0.002 18.8 0.5 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EFX02623.1 - 0.0046 16.3 0.1 0.021 14.2 0.0 2.0 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 EFX02623.1 - 0.005 16.8 3.1 0.13 12.2 0.1 3.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EFX02623.1 - 0.037 13.4 0.0 0.072 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFX02623.1 - 0.043 12.8 0.0 0.066 12.1 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain MIF4G PF02854.19 EFX02624.1 - 1.2e-50 172.1 0.0 1.7e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EFX02624.1 - 5.8e-23 80.8 0.2 1.5e-22 79.5 0.2 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 CDC45 PF02724.14 EFX02624.1 - 8.6 4.5 10.9 14 3.8 10.9 1.2 1 0 0 1 1 1 0 CDC45-like protein MMR_HSR1_Xtn PF16897.5 EFX02625.1 - 1.8e-34 117.9 0.1 5.7e-34 116.3 0.0 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EFX02625.1 - 2.8e-20 72.5 0.0 6.5e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EFX02625.1 - 1.4e-18 66.7 0.6 2.4e-18 65.9 0.1 1.7 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 EFX02625.1 - 3.6e-12 46.1 0.0 5.9e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFX02625.1 - 0.00024 21.2 0.2 0.12 12.4 0.0 2.6 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EFX02625.1 - 0.071 12.1 0.1 0.16 10.9 0.1 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MCM PF00493.23 EFX02625.1 - 0.092 11.8 0.0 0.26 10.3 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain EST1_DNA_bind PF10373.9 EFX02626.1 - 3.6e-40 138.2 0.1 1.9e-39 135.9 0.0 1.9 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EFX02626.1 - 2.2e-19 70.4 8.6 1.5e-18 67.7 3.7 3.3 3 0 0 3 3 3 1 Telomerase activating protein Est1 Acyl-CoA_dh_1 PF00441.24 EFX02627.1 - 1.5e-28 99.9 1.4 2.8e-28 99.0 1.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFX02627.1 - 6e-20 71.2 0.0 1.1e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EFX02627.1 - 6.7e-14 52.5 1.0 1.4e-13 51.5 0.3 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFX02627.1 - 3.3e-12 46.8 3.6 3.3e-12 46.8 3.6 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Arginase PF00491.21 EFX02628.1 - 3.1e-93 312.3 0.0 4.1e-93 311.9 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EFX02628.1 - 0.022 15.0 0.0 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 UPF0489 domain ResIII PF04851.15 EFX02629.1 - 3.7e-23 82.4 0.0 6.3e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFX02629.1 - 2.8e-12 47.0 0.0 2.3e-11 44.0 0.0 2.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFX02629.1 - 1.3e-11 44.6 0.0 2.7e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EFX02629.1 - 0.00015 21.6 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 EFX02629.1 - 0.023 13.9 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.9 EFX02629.1 - 0.14 11.0 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Acyl-CoA_dh_1 PF00441.24 EFX02630.1 - 4.6e-34 117.8 0.5 1e-33 116.6 0.5 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFX02630.1 - 3.7e-17 62.3 0.4 7.1e-17 61.4 0.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 EFX02630.1 - 1.6e-15 57.0 0.0 3.8e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 EFX02630.1 - 2.1e-09 38.0 2.6 6.6e-09 36.4 0.1 3.0 3 1 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFX02630.1 - 4.5e-05 23.7 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HIT PF01230.23 EFX02631.1 - 1e-23 83.9 0.3 1.5e-23 83.4 0.3 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFX02631.1 - 0.0017 18.8 0.4 0.0038 17.7 0.4 1.5 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding SOG2 PF10428.9 EFX02632.1 - 0.19 10.9 9.4 0.062 12.5 1.6 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein Mid2 PF04478.12 EFX02633.1 - 8.5e-08 32.2 4.0 1e-07 31.9 0.2 2.4 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor TMEM51 PF15345.6 EFX02633.1 - 0.029 14.2 0.2 0.053 13.4 0.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 LapA_dom PF06305.11 EFX02633.1 - 0.064 13.1 0.2 5.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain UCR_UQCRX_QCR9 PF05365.12 EFX02633.1 - 1.1 9.3 3.0 6.1 6.9 0.4 2.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like MFS_1 PF07690.16 EFX02634.1 - 1.2e-35 123.1 26.6 2.8e-35 121.9 26.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02634.1 - 2e-09 36.9 7.3 2e-09 36.9 7.3 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFX02634.1 - 0.0017 16.8 5.0 0.0017 16.8 5.0 2.2 1 1 2 3 3 3 1 Fungal trichothecene efflux pump (TRI12) ADH_N PF08240.12 EFX02635.1 - 9.8e-28 96.2 2.0 1.9e-27 95.3 2.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX02635.1 - 1.2e-11 44.7 0.0 9.6e-11 41.8 0.0 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX02635.1 - 1e-06 28.4 0.0 0.012 15.1 0.0 2.4 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFX02635.1 - 3.7e-06 28.0 0.0 8.4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EFX02635.1 - 0.03 13.9 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 EFX02635.1 - 0.046 13.1 0.0 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MFS_1 PF07690.16 EFX02636.1 - 2.6e-13 49.6 39.5 3.8e-13 49.1 39.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFX02636.1 - 1.7e-08 34.4 5.6 1.7e-08 34.4 5.6 2.3 2 1 1 3 3 3 1 Ion channel regulatory protein UNC-93 Zn_clus PF00172.18 EFX02637.1 - 0.046 13.8 7.4 0.11 12.6 7.4 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_6 PF13912.6 EFX02637.1 - 0.11 12.6 1.4 0.65 10.1 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.15 EFX02637.1 - 0.74 9.9 3.3 0.41 10.7 0.3 2.1 2 0 0 2 2 2 0 BED zinc finger COX2_TM PF02790.15 EFX02638.1 - 0.021 15.0 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain OAD_gamma PF04277.13 EFX02638.1 - 0.7 10.5 4.0 16 6.1 0.3 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain KIP1 PF07765.12 EFX02640.1 - 0.48 10.6 5.2 1.9 8.6 5.2 2.1 1 0 0 1 1 1 0 KIP1-like protein Fmp27_WPPW PF10359.9 EFX02640.1 - 1.1 8.1 11.2 0.67 8.7 7.9 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain OmpH PF03938.14 EFX02640.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.7 3 1 1 4 4 4 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 EFX02640.1 - 3.4 7.0 31.5 0.25 10.8 19.5 2.5 3 0 0 3 3 3 0 Golgin subfamily A member 5 TMPIT PF07851.13 EFX02640.1 - 5.5 6.2 7.9 12 5.1 7.9 1.6 1 0 0 1 1 1 0 TMPIT-like protein DUF4559 PF15112.6 EFX02640.1 - 6.6 6.3 10.0 14 5.2 10.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) ELFV_dehydrog PF00208.21 EFX02642.1 - 4.4e-62 210.0 0.0 6.9e-62 209.3 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EFX02642.1 - 3.1e-20 71.4 0.0 1.6e-15 55.8 0.0 2.4 2 1 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EFX02642.1 - 0.004 17.0 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain MFS_1 PF07690.16 EFX02643.1 - 1.2e-33 116.5 29.6 3.2e-33 115.1 28.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Transferase PF02458.15 EFX02644.1 - 0.0098 14.6 0.0 0.85 8.2 0.0 2.0 2 0 0 2 2 2 2 Transferase family Cut12 PF11500.8 EFX02645.1 - 2.2e-41 141.2 14.6 2.2e-41 141.2 14.6 5.1 3 2 1 5 5 5 2 Spindle pole body formation-associated protein UreF PF01730.16 EFX02645.1 - 2.7e-22 79.8 3.1 2.7e-22 79.8 3.1 3.5 3 1 0 3 3 3 1 UreF Sugarporin_N PF11471.8 EFX02645.1 - 0.00026 20.9 0.1 0.00026 20.9 0.1 5.1 4 1 1 5 5 5 2 Maltoporin periplasmic N-terminal extension Vps53_N PF04100.12 EFX02645.1 - 6.8 5.5 15.8 0.48 9.3 4.3 2.6 2 1 0 2 2 2 0 Vps53-like, N-terminal Glyco_hydro_92 PF07971.12 EFX02646.1 - 1.6e-112 376.8 0.0 1.1e-56 192.8 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EFX02646.1 - 3.5e-59 200.6 0.8 5.9e-59 199.8 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain FAD_binding_3 PF01494.19 EFX02647.1 - 3e-14 53.0 3.7 3.9e-05 23.1 0.2 3.1 2 1 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 EFX02647.1 - 3.4e-08 33.6 0.0 1.2e-07 31.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX02647.1 - 2.5e-05 24.0 0.9 6.6e-05 22.7 0.9 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX02647.1 - 3.4e-05 23.1 0.2 8.4e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX02647.1 - 3.9e-05 23.0 0.0 0.019 14.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX02647.1 - 0.00016 21.1 0.1 0.026 13.8 0.0 2.7 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EFX02647.1 - 0.0049 15.6 0.1 0.015 14.0 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EFX02647.1 - 0.028 15.0 0.0 0.17 12.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX02647.1 - 0.043 13.0 0.1 0.096 11.9 0.1 1.6 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EFX02647.1 - 0.16 11.0 0.1 0.25 10.4 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Mito_carr PF00153.27 EFX02648.1 - 2.9e-59 197.0 1.5 1.4e-20 73.0 0.7 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein SRP9-21 PF05486.12 EFX02648.1 - 0.63 10.5 3.2 1.3 9.5 3.2 1.4 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Aminotran_1_2 PF00155.21 EFX02649.1 - 6.6e-14 51.9 0.0 9.2e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EFX02649.1 - 0.00016 20.6 0.0 0.0092 14.8 0.0 2.2 2 0 0 2 2 2 2 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 EFX02649.1 - 0.084 12.2 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Questin_oxidase PF14027.6 EFX02650.1 - 6.7e-31 108.1 0.0 8.5e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Questin oxidase-like DUF2600 PF10776.9 EFX02650.1 - 0.053 12.4 0.0 0.078 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) Zip PF02535.22 EFX02651.1 - 5.4e-35 121.2 12.2 1.1e-34 120.1 12.2 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter DUF2014 PF09427.10 EFX02651.1 - 0.056 12.8 1.2 0.11 11.8 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) WD40 PF00400.32 EFX02653.1 - 4e-22 78.1 18.9 4.3e-06 27.4 0.3 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02653.1 - 6.4e-12 45.6 0.5 0.027 14.8 0.0 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX02653.1 - 0.1 12.5 0.0 8.5 6.2 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A GCV_T_C PF08669.11 EFX02653.1 - 0.14 12.1 0.1 0.4 10.6 0.1 1.8 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain 2-Hacid_dh_C PF02826.19 EFX02654.1 - 4.4e-28 97.8 0.0 4.6e-27 94.5 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FYVE PF01363.21 EFX02655.1 - 2.8e-08 33.8 3.3 2.8e-08 33.8 3.3 3.3 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EFX02655.1 - 1.2e-07 31.9 5.2 1.2e-07 31.9 5.2 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFX02655.1 - 5.8e-05 22.9 4.6 5.8e-05 22.9 4.6 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFX02655.1 - 0.00017 21.3 4.9 0.00017 21.3 4.9 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFX02655.1 - 0.0024 17.9 5.6 0.0024 17.9 5.6 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING-like PF08746.11 EFX02655.1 - 0.02 15.2 2.7 0.02 15.2 2.7 2.3 3 0 0 3 3 3 0 RING-like domain Rad50_zn_hook PF04423.14 EFX02655.1 - 0.19 11.6 2.5 0.26 11.1 0.4 2.1 2 0 0 2 2 2 0 Rad50 zinc hook motif TPR_12 PF13424.6 EFX02656.1 - 3.6e-17 62.4 1.2 2.8e-13 49.9 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX02656.1 - 6.5e-17 60.8 4.3 7.5e-07 28.8 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02656.1 - 4.9e-11 41.9 0.9 0.0002 21.2 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02656.1 - 2e-09 36.8 0.6 0.011 15.8 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_16 PF13191.6 EFX02656.1 - 1.3e-07 32.2 0.2 3.4e-06 27.5 0.2 2.6 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EFX02656.1 - 5.3e-07 29.1 0.0 1.1e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 NB-ARC domain TPR_1 PF00515.28 EFX02656.1 - 5.1e-06 26.1 0.1 0.051 13.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_22 PF13401.6 EFX02656.1 - 0.00036 20.8 0.0 0.0011 19.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain TPR_19 PF14559.6 EFX02656.1 - 0.0004 20.8 0.0 0.091 13.3 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat PPR PF01535.20 EFX02656.1 - 0.0006 19.9 0.0 5 7.6 0.0 3.7 3 0 0 3 3 3 1 PPR repeat TPR_8 PF13181.6 EFX02656.1 - 0.0023 18.0 0.1 0.37 11.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFX02656.1 - 0.0062 16.8 0.8 0.52 10.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFX02656.1 - 0.0087 16.7 0.1 20 5.9 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Pox_A32 PF04665.12 EFX02656.1 - 0.025 14.0 0.0 0.049 13.1 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein TPR_6 PF13174.6 EFX02656.1 - 0.031 14.9 1.9 3.1 8.6 0.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat ATPase_2 PF01637.18 EFX02656.1 - 0.035 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MeaB PF03308.16 EFX02656.1 - 0.11 11.5 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TPR_14 PF13428.6 EFX02656.1 - 0.11 13.3 0.7 42 5.3 0.0 3.9 4 0 0 4 4 2 0 Tetratricopeptide repeat NPCC PF08058.11 EFX02657.1 - 3.2e-21 75.7 0.0 5.6e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore complex component MFS_1 PF07690.16 EFX02659.1 - 9.1e-40 136.7 27.5 9.1e-40 136.7 27.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02659.1 - 1.2e-10 40.8 4.9 1.2e-10 40.8 4.9 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFX02659.1 - 0.00044 18.8 3.9 0.00066 18.2 3.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 EFX02660.1 - 1.6e-15 56.8 0.0 2.3e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DAO PF01266.24 EFX02661.1 - 6e-47 160.9 0.1 1.1e-46 160.1 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EFX02661.1 - 4.6e-37 126.7 0.9 8.4e-37 125.9 0.9 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EFX02661.1 - 1.4e-10 40.8 8.1 7e-05 22.1 0.2 2.4 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EFX02661.1 - 1.6e-06 27.6 1.0 7.9e-06 25.3 1.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX02661.1 - 3.6e-05 23.3 1.0 3.6e-05 23.3 1.0 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX02661.1 - 0.0025 18.0 0.3 0.0071 16.5 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFX02661.1 - 0.0035 16.7 1.5 0.12 11.6 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX02661.1 - 0.0042 16.2 2.6 0.013 14.6 0.5 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX02661.1 - 0.0051 15.9 0.6 0.056 12.5 0.2 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EFX02661.1 - 0.006 15.3 0.7 0.0094 14.7 0.7 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EFX02661.1 - 0.025 15.1 1.6 0.048 14.2 0.4 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EFX02661.1 - 0.039 13.8 0.3 0.039 13.8 0.3 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 EFX02661.1 - 0.048 12.9 0.2 0.34 10.1 0.2 2.2 2 0 0 2 2 2 0 Thi4 family DUF4826 PF16108.5 EFX02662.1 - 0.18 12.0 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4826) PA PF02225.22 EFX02662.1 - 0.62 10.1 2.5 0.92 9.6 2.5 1.5 1 1 0 1 1 1 0 PA domain Voldacs PF03517.13 EFX02664.1 - 9.4e-25 87.4 0.0 2.1e-24 86.2 0.0 1.6 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling AA_permease PF00324.21 EFX02665.1 - 4.2e-134 447.7 31.6 5.3e-134 447.4 31.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX02665.1 - 4.8e-41 141.0 34.1 6.9e-41 140.4 34.1 1.1 1 0 0 1 1 1 1 Amino acid permease TPR_10 PF13374.6 EFX02665.1 - 0.0065 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02665.1 - 0.015 15.6 0.0 0.025 14.9 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Gemini_mov PF01708.16 EFX02666.1 - 0.99 9.2 4.1 0.5 10.2 0.7 2.2 2 0 0 2 2 2 0 Geminivirus putative movement protein TPR_10 PF13374.6 EFX02667.1 - 1.3e-65 215.7 11.9 1.7e-14 53.1 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFX02667.1 - 2.5e-59 197.5 22.5 1.4e-19 70.1 0.7 5.9 1 1 4 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFX02667.1 - 5.4e-18 63.6 7.7 0.012 15.6 0.1 6.1 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFX02667.1 - 5.3e-13 49.4 3.6 0.00017 22.2 0.1 5.6 2 1 4 6 6 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFX02667.1 - 8e-13 47.5 12.5 0.0024 17.9 0.2 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFX02667.1 - 3.1e-11 42.6 5.2 0.042 13.7 0.2 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFX02667.1 - 9.2e-11 41.4 0.9 0.19 12.2 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_4 PF07721.14 EFX02667.1 - 2.2e-10 40.1 11.4 0.25 12.1 0.1 6.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFX02667.1 - 2.5e-10 40.7 6.9 0.00065 20.2 1.5 4.3 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EFX02667.1 - 3.7e-09 36.4 7.7 7e-09 35.5 7.7 1.5 1 0 0 1 1 1 1 MalT-like TPR region NB-ARC PF00931.22 EFX02667.1 - 1.5e-06 27.6 0.0 3.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ANAPC3 PF12895.7 EFX02667.1 - 0.00069 19.8 2.4 5.6 7.3 0.2 3.9 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 EFX02667.1 - 0.00072 19.1 3.9 1.8 7.9 0.2 3.7 1 1 3 4 4 4 2 Coatomer epsilon subunit TPR_3 PF07720.12 EFX02667.1 - 0.00089 19.2 1.2 0.65 10.1 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFX02667.1 - 0.0086 16.2 7.0 13 6.3 0.1 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFX02667.1 - 0.026 15.3 8.3 10 7.3 0.1 5.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFX02667.1 - 0.15 11.8 4.3 24 4.7 0.1 4.2 4 0 0 4 4 4 0 TPR repeat N1221 PF07923.13 EFX02667.1 - 0.15 11.3 3.5 0.62 9.2 0.8 2.7 2 1 0 2 2 2 0 N1221-like protein TPR_6 PF13174.6 EFX02667.1 - 1.3 9.8 10.9 58 4.6 0.2 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat Septin PF00735.18 EFX02668.1 - 2.3e-119 397.9 0.5 2.3e-119 397.9 0.5 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EFX02668.1 - 4.3e-08 33.2 0.9 1e-07 32.0 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFX02668.1 - 5.3e-05 23.2 3.0 0.0017 18.3 0.7 3.1 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFX02668.1 - 8.8e-05 22.1 2.6 0.001 18.7 0.0 2.9 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EFX02668.1 - 0.00075 18.9 1.2 0.0014 18.0 0.0 2.0 2 0 0 2 2 2 1 AIG1 family ABC_tran PF00005.27 EFX02668.1 - 0.00096 19.7 3.1 0.028 14.9 0.0 2.7 2 1 1 3 3 3 1 ABC transporter Roc PF08477.13 EFX02668.1 - 0.0015 18.7 0.0 0.0032 17.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EFX02668.1 - 0.0022 18.4 0.0 0.0059 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFX02668.1 - 0.0071 16.6 0.1 0.043 14.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain Ras PF00071.22 EFX02668.1 - 0.014 15.0 0.0 0.042 13.4 0.0 1.8 1 0 0 1 1 1 0 Ras family AAA_29 PF13555.6 EFX02668.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EFX02668.1 - 0.034 13.9 0.4 4.8 6.9 0.0 3.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 EFX02668.1 - 0.06 12.7 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 EFX02668.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFX02668.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFX02668.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EFX02668.1 - 0.16 12.3 0.1 0.55 10.6 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.23 EFX02668.1 - 0.18 11.8 7.8 1.1 9.3 0.0 3.5 3 1 0 3 3 3 0 Dynamin family Exonuc_VII_L PF02601.15 EFX02668.1 - 1.2 8.7 7.2 1.9 8.0 7.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EFX02668.1 - 2 7.4 8.3 3.1 6.8 8.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Asp PF00026.23 EFX02669.1 - 2.5e-70 237.4 3.7 3.2e-70 237.1 3.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX02669.1 - 4.4e-14 53.1 6.4 7e-13 49.2 2.4 3.6 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX02669.1 - 0.00017 22.2 5.1 0.79 10.4 0.1 4.5 3 2 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EFX02669.1 - 0.021 15.4 0.8 25 5.5 0.0 4.1 4 2 0 4 4 4 0 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EFX02669.1 - 0.027 14.2 0.0 0.08 12.7 0.0 1.8 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal DND1_DSRM PF14709.7 EFX02670.1 - 0.00066 19.9 0.1 0.0011 19.1 0.1 1.5 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.26 EFX02670.1 - 0.0014 19.3 0.0 0.0028 18.3 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif PAP1 PF08601.10 EFX02671.1 - 8.3e-67 226.5 31.1 2.7e-43 149.1 0.0 3.2 2 1 1 3 3 3 2 Transcription factor PAP1 bZIP_1 PF00170.21 EFX02671.1 - 1.1e-07 31.9 10.1 2.1e-07 31.0 10.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 EFX02671.1 - 0.012 15.4 0.3 0.021 14.6 0.3 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_2 PF07716.15 EFX02671.1 - 0.026 14.6 10.9 0.082 13.0 10.9 1.8 1 1 0 1 1 1 0 Basic region leucine zipper CDC45 PF02724.14 EFX02671.1 - 0.072 11.4 5.4 0.098 10.9 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Alpha_adaptinC2 PF02883.20 EFX02671.1 - 0.089 13.1 0.4 0.25 11.6 0.4 1.7 1 0 0 1 1 1 0 Adaptin C-terminal domain dsrm PF00035.26 EFX02671.1 - 0.12 13.1 0.0 0.29 11.9 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding motif ADIP PF11559.8 EFX02671.1 - 2.6 8.1 7.6 4 7.5 6.5 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding AMP-binding PF00501.28 EFX02672.1 - 1.5e-22 79.8 0.1 3.3e-22 78.7 0.1 1.5 1 1 0 1 1 1 1 AMP-binding enzyme NAD_binding_10 PF13460.6 EFX02673.1 - 3.6e-07 30.3 0.0 1.8e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFX02673.1 - 0.011 15.3 0.0 0.024 14.2 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family DUF1690 PF07956.11 EFX02674.1 - 5e-44 150.1 0.0 5.7e-44 149.9 0.0 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Nup188_C PF18378.1 EFX02676.1 - 1.7e-135 451.7 0.0 3.1e-135 450.8 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Pkinase PF00069.25 EFX02676.1 - 9.9e-38 130.0 0.0 1.9e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Nup188 PF10487.9 EFX02676.1 - 1.5e-30 105.9 0.0 3.6e-17 61.6 0.0 3.0 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Pkinase_Tyr PF07714.17 EFX02676.1 - 1.3e-20 73.8 0.0 2.4e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Rad10 PF03834.14 EFX02677.1 - 3.8e-46 155.8 0.0 5.1e-46 155.4 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EFX02677.1 - 0.0021 18.6 0.5 0.0086 16.7 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain FAD_binding_2 PF00890.24 EFX02678.1 - 5.6e-05 22.4 0.0 6.9e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX02678.1 - 0.00014 21.6 0.0 0.00017 21.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX02678.1 - 0.0003 20.1 0.0 0.00036 19.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX02678.1 - 0.00053 20.2 0.0 0.00085 19.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EFX02678.1 - 0.0017 17.7 0.0 0.002 17.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFX02678.1 - 0.0064 15.2 0.0 0.008 14.9 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EFX02678.1 - 0.0073 15.6 0.0 0.0094 15.2 0.0 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFX02678.1 - 0.018 14.3 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX02678.1 - 0.043 13.2 0.1 0.055 12.8 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFX02678.1 - 0.047 12.8 0.0 0.056 12.5 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EFX02678.1 - 0.095 12.0 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EFX02678.1 - 0.15 12.6 0.0 0.22 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX02678.1 - 0.16 11.0 0.1 0.2 10.7 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pkinase PF00069.25 EFX02679.1 - 1.7e-69 234.1 0.0 2.5e-69 233.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02679.1 - 2.1e-33 115.7 0.0 4.8e-33 114.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX02679.1 - 0.0011 18.4 0.1 0.0029 17.0 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFX02679.1 - 0.01 15.2 0.6 0.032 13.6 0.6 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFX02680.1 - 2.5e-68 230.3 0.0 3.9e-68 229.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02680.1 - 2e-32 112.5 0.0 2.9e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX02680.1 - 7.6e-07 28.7 0.0 1.1e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFX02680.1 - 0.00031 20.2 0.0 0.00058 19.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFX02680.1 - 0.00067 18.5 0.0 0.0013 17.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFX02680.1 - 0.0012 18.5 0.1 0.02 14.4 0.1 2.6 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Homeodomain PF00046.29 EFX02681.1 - 4.8e-09 35.9 0.4 2.9e-06 27.0 0.0 2.8 2 0 0 2 2 2 2 Homeodomain Rhodanese PF00581.20 EFX02681.1 - 2.6e-05 24.7 0.0 7e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Oxidored_FMN PF00724.20 EFX02683.1 - 3.3e-87 293.0 0.0 4.2e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 EFX02683.1 - 0.02 14.4 0.1 1.8 7.9 0.0 3.0 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel COPI_assoc PF08507.10 EFX02684.1 - 2.4e-34 118.2 10.1 4.3e-34 117.4 10.1 1.5 1 0 0 1 1 1 1 COPI associated protein efThoc1 PF11957.8 EFX02685.1 - 1.9e-131 439.1 1.0 1.9e-131 439.1 1.0 1.7 2 0 0 2 2 2 1 THO complex subunit 1 transcription elongation factor Aldo_ket_red PF00248.21 EFX02686.1 - 1.5e-67 227.8 0.0 1.8e-67 227.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Claudin_3 PF06653.11 EFX02686.1 - 0.22 11.5 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like RRM_1 PF00076.22 EFX02687.1 - 5.6e-37 125.4 0.0 8.4e-12 44.7 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFX02687.1 - 5.8e-15 54.9 0.0 0.064 13.1 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM PF10378.9 EFX02687.1 - 5.5e-06 26.0 13.0 5.5e-06 26.0 13.0 3.3 2 1 0 2 2 2 1 Putative RRM domain RRM_7 PF16367.5 EFX02687.1 - 1.9e-05 24.7 0.0 0.082 13.0 0.0 3.9 4 0 0 4 4 4 2 RNA recognition motif DUF4523 PF15023.6 EFX02687.1 - 3e-05 23.9 0.0 0.027 14.3 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF4523) RRM_Rrp7 PF17799.1 EFX02687.1 - 0.01 15.7 0.0 0.87 9.4 0.0 3.5 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain Nup35_RRM_2 PF14605.6 EFX02687.1 - 0.033 14.2 0.0 10 6.2 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 EFX02687.1 - 0.066 13.2 0.6 0.3 11.1 0.0 2.4 3 0 0 3 3 3 0 RNA binding domain RRM_3 PF08777.11 EFX02687.1 - 0.1 12.7 6.0 0.17 11.9 0.1 3.1 4 0 0 4 4 4 0 RNA binding motif Glycos_transf_2 PF00535.26 EFX02688.1 - 6.9e-23 81.3 0.0 1.1e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFX02688.1 - 2e-06 27.9 0.2 2.7e-05 24.2 0.2 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFX02688.1 - 0.081 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Lipase_3 PF01764.25 EFX02689.1 - 3.1e-24 85.4 0.0 5.1e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EFX02689.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 EFX02689.1 - 0.15 12.6 6.4 0.2 12.2 4.9 1.8 1 1 1 2 2 2 0 Alpha/beta hydrolase family Peptidase_C12 PF01088.21 EFX02690.1 - 9.2e-54 182.4 0.0 1.1e-53 182.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Glyoxalase PF00903.25 EFX02690.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Rft-1 PF04506.13 EFX02692.1 - 1.8e-139 465.8 0.0 2.1e-139 465.6 0.0 1.1 1 0 0 1 1 1 1 Rft protein Diphthamide_syn PF01866.17 EFX02692.1 - 8.2e-85 284.9 0.0 1.1e-84 284.5 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Polysacc_synt_3 PF13440.6 EFX02692.1 - 0.0014 17.9 3.9 0.1 11.8 0.0 2.5 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 EFX02692.1 - 0.0046 16.4 3.2 0.0046 16.4 3.2 2.8 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein Hid1 PF12722.7 EFX02693.1 - 9e-288 956.9 0.0 1.6e-255 850.2 0.0 2.6 2 1 0 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EFX02693.1 - 1.2e-98 331.2 0.0 1.6e-97 327.5 0.0 1.9 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF4820 PF16091.5 EFX02693.1 - 0.011 15.1 0.4 0.018 14.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CDC45 PF02724.14 EFX02693.1 - 0.42 8.9 2.2 0.76 8.0 2.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 EFX02693.1 - 0.42 10.3 11.1 0.61 9.8 11.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Tub_N PF16322.5 EFX02693.1 - 0.58 10.5 9.6 0.97 9.8 9.6 1.3 1 0 0 1 1 1 0 Tubby N-terminal Roughex PF06020.11 EFX02693.1 - 1.2 8.1 8.7 1.9 7.5 8.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein BUD22 PF09073.10 EFX02693.1 - 1.6 8.0 10.4 2.3 7.4 10.4 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EFX02693.1 - 2.3 7.5 9.3 3.3 7.1 9.3 1.1 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 EFX02693.1 - 5.2 6.6 10.0 7.9 6.0 10.0 1.2 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 EFX02693.1 - 5.2 5.1 12.1 4.1 5.5 10.1 1.7 2 0 0 2 2 2 0 Nop14-like family YhcG_C PF06250.11 EFX02694.1 - 0.16 11.8 0.0 0.46 10.3 0.0 1.7 1 1 1 2 2 2 0 YhcG PDDEXK nuclease domain Cu_amine_oxid PF01179.20 EFX02695.1 - 1.2e-152 508.6 0.0 1.5e-152 508.3 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EFX02695.1 - 3.7e-19 69.0 0.0 1e-18 67.6 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EFX02695.1 - 1.6e-14 53.9 0.1 7.2e-14 51.8 0.1 2.1 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain RINGv PF12906.7 EFX02695.1 - 0.085 13.0 0.2 12 6.1 0.0 2.6 2 0 0 2 2 2 0 RING-variant domain Aminotran_3 PF00202.21 EFX02696.1 - 2.6e-116 388.7 0.0 2.9e-116 388.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EFX02696.1 - 0.0033 16.8 0.0 0.0081 15.5 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EFX02696.1 - 0.14 11.3 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Seryl_tRNA_N PF02403.22 EFX02698.1 - 0.85 9.9 4.7 2.8 8.2 4.2 2.2 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Peptidase_S24 PF00717.23 EFX02699.1 - 0.00017 21.4 0.2 0.0012 18.8 0.2 2.2 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EFX02699.1 - 0.042 13.6 0.1 1.7 8.4 0.0 2.2 1 1 1 2 2 2 0 Signal peptidase, peptidase S26 CFEM PF05730.11 EFX02700.1 - 0.0033 17.5 5.9 0.0085 16.2 5.9 1.7 1 0 0 1 1 1 1 CFEM domain DUF2561 PF10812.8 EFX02700.1 - 0.052 13.6 9.3 0.12 12.5 9.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) ATP1G1_PLM_MAT8 PF02038.16 EFX02700.1 - 0.14 11.7 0.3 0.14 11.7 0.3 1.6 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family fn3_5 PF06280.12 EFX02700.1 - 1.5 9.5 7.0 2.5 8.8 7.0 1.3 1 0 0 1 1 1 0 Fn3-like domain DUF1664 PF07889.12 EFX02701.1 - 0.0015 18.5 13.8 0.15 12.1 1.6 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) MscS_porin PF12795.7 EFX02701.1 - 0.0019 17.8 25.7 0.4 10.2 8.9 2.3 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain Tropomyosin PF00261.20 EFX02701.1 - 0.002 17.5 11.4 0.002 17.5 11.4 2.8 1 1 3 4 4 4 2 Tropomyosin FPP PF05911.11 EFX02701.1 - 0.0021 16.3 21.1 0.0036 15.6 21.1 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ATG16 PF08614.11 EFX02701.1 - 0.0022 18.3 25.3 0.0055 17.0 25.3 1.7 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) ADIP PF11559.8 EFX02701.1 - 0.003 17.6 11.6 0.003 17.6 11.6 2.8 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding BRE1 PF08647.11 EFX02701.1 - 0.0033 17.5 6.8 0.0033 17.5 6.8 2.7 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase Fez1 PF06818.15 EFX02701.1 - 0.006 17.1 24.9 0.03 14.8 11.0 2.6 1 1 1 2 2 2 1 Fez1 CALCOCO1 PF07888.11 EFX02701.1 - 0.013 14.4 23.6 0.026 13.4 23.6 1.4 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3037 PF11236.8 EFX02701.1 - 0.014 15.8 2.0 0.014 15.8 2.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) DMPK_coil PF08826.10 EFX02701.1 - 0.015 15.4 2.0 0.015 15.4 2.0 4.1 2 1 3 5 5 4 0 DMPK coiled coil domain like Atg14 PF10186.9 EFX02701.1 - 0.034 13.2 17.8 0.098 11.7 17.8 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF236 PF03057.14 EFX02701.1 - 0.051 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 DUF236 repeat TPR_MLP1_2 PF07926.12 EFX02701.1 - 0.055 13.5 33.5 1.1 9.3 15.0 3.7 2 1 0 3 3 2 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.19 EFX02701.1 - 0.06 11.3 9.2 0.081 10.8 9.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Carbam_trans_C PF16861.5 EFX02701.1 - 0.067 12.8 0.3 0.28 10.8 0.1 2.0 2 0 0 2 2 2 0 Carbamoyltransferase C-terminus CCDC144C PF14915.6 EFX02701.1 - 0.078 12.1 25.1 3.9 6.5 22.6 2.5 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region DUF4407 PF14362.6 EFX02701.1 - 0.08 12.3 15.2 0.14 11.5 15.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 EFX02701.1 - 0.092 13.3 30.4 0.53 10.8 8.6 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region CHDCT2 PF08074.11 EFX02701.1 - 0.12 12.6 10.2 0.13 12.5 4.2 2.4 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain PI3K_P85_iSH2 PF16454.5 EFX02701.1 - 0.15 11.7 17.9 0.12 12.0 1.7 3.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4201 PF13870.6 EFX02701.1 - 0.15 11.8 20.4 0.052 13.3 5.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) HIP1_clath_bdg PF16515.5 EFX02701.1 - 0.19 12.4 26.1 5.3 7.7 1.6 3.8 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Csm1_N PF18504.1 EFX02701.1 - 0.24 11.7 18.9 0.72 10.2 2.5 3.7 1 1 3 4 4 4 0 Csm1 N-terminal domain RILP PF11461.8 EFX02701.1 - 0.25 11.6 6.1 0.42 10.9 2.2 2.9 2 1 1 3 3 2 0 Rab interacting lysosomal protein DUF1043 PF06295.12 EFX02701.1 - 0.27 11.2 18.4 0.53 10.3 9.8 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) WEMBL PF05701.11 EFX02701.1 - 0.37 9.4 24.0 1.2 7.7 23.8 1.7 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Spc7 PF08317.11 EFX02701.1 - 0.44 9.4 27.4 7.4 5.4 27.1 2.2 1 1 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EFX02701.1 - 0.54 10.3 30.9 0.15 12.1 21.2 3.6 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CdvA PF18822.1 EFX02701.1 - 0.59 10.0 16.1 0.3 10.9 0.5 3.2 1 1 1 2 2 2 0 CdvA-like coiled-coil domain CCDC-167 PF15188.6 EFX02701.1 - 0.76 10.2 13.9 0.13 12.6 5.5 2.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Golgin_A5 PF09787.9 EFX02701.1 - 0.98 8.8 23.6 1.5 8.2 21.3 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Tup_N PF08581.10 EFX02701.1 - 1 9.7 15.8 4.1 7.8 0.2 3.7 1 1 2 3 3 3 0 Tup N-terminal COG2 PF06148.11 EFX02701.1 - 1 9.4 17.5 0.41 10.8 5.9 2.9 2 1 1 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cep57_CLD_2 PF14197.6 EFX02701.1 - 1.4 9.1 27.3 0.046 13.8 1.9 4.1 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 DUF3584 PF12128.8 EFX02701.1 - 1.5 6.2 23.8 0.3 8.6 8.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Mod_r PF07200.13 EFX02701.1 - 1.8 8.6 27.9 10 6.2 12.8 3.1 2 1 1 3 3 2 0 Modifier of rudimentary (Mod(r)) protein UPF0242 PF06785.11 EFX02701.1 - 1.9 8.6 25.3 1.8 8.6 14.1 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 EFX02701.1 - 2 8.7 25.7 0.11 12.7 6.0 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF724 PF05266.14 EFX02701.1 - 2 8.2 18.8 7.3 6.4 16.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) GAS PF13851.6 EFX02701.1 - 2.8 7.3 26.7 0.44 9.9 13.0 2.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Bacillus_HBL PF05791.11 EFX02701.1 - 3.2 7.5 11.0 0.29 10.9 3.5 2.3 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Cytochrom_C_2 PF01322.20 EFX02701.1 - 3.5 8.5 8.1 1.9 9.4 1.7 2.7 1 1 2 3 3 3 0 Cytochrome C' OmpH PF03938.14 EFX02701.1 - 4.5 7.6 22.6 5.1 7.4 10.4 3.9 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 EFX02701.1 - 5.5 7.5 13.5 5.1 7.6 0.7 4.4 3 1 0 4 4 3 0 Flagella accessory protein C (FlaC) DUF883 PF05957.13 EFX02701.1 - 5.6 7.6 18.7 20 5.9 0.1 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Laminin_II PF06009.12 EFX02701.1 - 6.3 6.8 18.1 11 6.0 1.4 3.4 1 1 2 3 3 3 0 Laminin Domain II IFT57 PF10498.9 EFX02701.1 - 6.6 5.6 20.7 3.9 6.4 11.2 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF4795 PF16043.5 EFX02701.1 - 7 6.2 21.3 0.88 9.1 10.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Seryl_tRNA_N PF02403.22 EFX02701.1 - 8.5 6.7 22.4 1.9 8.8 8.8 3.7 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain DUF641 PF04859.12 EFX02701.1 - 9 6.6 17.5 21 5.5 6.3 3.7 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) S4 PF01479.25 EFX02702.1 - 2.8e-11 42.9 0.0 4.8e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EFX02702.1 - 1.5e-10 41.9 0.2 2.1e-10 41.4 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain F-box-like PF12937.7 EFX02703.1 - 1e-09 38.1 0.0 2.4e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX02703.1 - 1.1e-07 31.5 0.0 2.1e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 F-box domain UIM PF02809.20 EFX02703.1 - 5.1e-05 22.9 6.6 0.0044 16.9 0.4 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif Methyltransf_23 PF13489.6 EFX02704.1 - 7.5e-17 61.6 0.0 1.2e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02704.1 - 5e-07 30.3 0.0 1.3e-06 29.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02704.1 - 5.5e-06 26.2 0.0 0.00012 21.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02704.1 - 5.3e-05 23.9 0.0 0.00061 20.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFX02704.1 - 0.014 15.0 0.0 0.069 12.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX02704.1 - 0.019 14.5 0.0 0.049 13.1 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Ubie_methyltran PF01209.18 EFX02704.1 - 0.029 13.7 0.0 0.2 11.0 0.0 2.2 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family WD40 PF00400.32 EFX02705.1 - 1.7e-17 63.5 8.2 0.0055 17.5 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02705.1 - 0.0049 17.1 0.1 2.5 8.5 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DAZAP2 PF11029.8 EFX02705.1 - 0.036 15.0 0.7 0.072 14.0 0.2 1.8 2 0 0 2 2 2 0 DAZ associated protein 2 (DAZAP2) MTHFR PF02219.17 EFX02706.1 - 3.2e-106 354.9 0.0 4.4e-106 354.4 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase FAD_binding_4 PF01565.23 EFX02707.1 - 6.8e-24 84.2 1.0 1.3e-23 83.3 1.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX02707.1 - 0.00045 20.3 0.7 0.0011 19.0 0.7 1.7 1 0 0 1 1 1 1 Berberine and berberine like GPI-anchored PF10342.9 EFX02708.1 - 1.4e-22 80.3 2.3 1.4e-22 80.3 2.3 3.2 2 1 2 4 4 4 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.6 EFX02708.1 - 0.0001 22.2 0.6 0.00019 21.2 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) FAD_binding_1 PF00667.20 EFX02709.1 - 1e-25 90.6 0.0 4.6e-25 88.5 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 EFX02709.1 - 9.1e-19 68.1 0.0 2.8e-18 66.5 0.0 1.8 1 1 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFX02709.1 - 8.4e-13 48.9 0.0 1e-09 39.0 0.0 2.6 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain eRF1_2 PF03464.15 EFX02710.1 - 1.8e-45 154.5 0.0 2.8e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFX02710.1 - 2.5e-39 134.3 0.4 4.8e-39 133.3 0.4 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EFX02710.1 - 2e-21 76.4 0.0 3.2e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EFX02710.1 - 2.4e-10 40.8 0.1 7.4e-10 39.2 0.0 1.8 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EFX02710.1 - 7.8e-09 35.9 0.0 1.4e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor ATG101 PF07855.12 EFX02711.1 - 2.1e-56 190.2 0.0 2.5e-56 190.0 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 Pkinase PF00069.25 EFX02712.1 - 4.3e-69 232.8 1.6 6.3e-68 229.0 1.6 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02712.1 - 1.6e-53 181.6 0.1 2.6e-53 180.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EFX02712.1 - 3.9e-24 84.8 0.2 1.5e-23 82.9 0.0 2.2 2 0 0 2 2 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EFX02712.1 - 7.4e-07 28.8 0.0 1.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFX02712.1 - 8.4e-06 24.8 0.0 8.4e-06 24.8 0.0 2.1 2 1 0 2 2 1 1 Fungal protein kinase PH_11 PF15413.6 EFX02712.1 - 8.4e-05 22.9 0.4 0.00032 21.1 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain Haspin_kinase PF12330.8 EFX02712.1 - 0.0032 16.5 2.5 0.027 13.4 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFX02712.1 - 0.015 15.2 0.2 0.064 13.2 0.2 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFX02712.1 - 0.026 13.6 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PH PF00169.29 EFX02712.1 - 0.031 14.8 0.0 0.078 13.5 0.0 1.7 1 0 0 1 1 1 0 PH domain SHE3 PF17078.5 EFX02712.1 - 0.2 11.4 5.3 0.39 10.4 5.3 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 APP_E2 PF12925.7 EFX02712.1 - 0.43 10.3 8.0 0.8 9.4 8.0 1.4 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein His_Phos_2 PF00328.22 EFX02713.1 - 9e-54 183.3 0.0 1.4e-53 182.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) adh_short_C2 PF13561.6 EFX02714.1 - 1.9e-63 214.2 0.2 2.1e-63 214.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX02714.1 - 1.6e-45 155.0 0.0 2e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX02714.1 - 4.6e-10 39.7 2.1 9.4e-10 38.7 2.1 1.5 1 1 0 1 1 1 1 KR domain HHH_5 PF14520.6 EFX02714.1 - 0.04 14.5 0.2 0.13 12.9 0.1 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain MoCF_biosynth PF00994.24 EFX02715.1 - 2.1e-50 170.2 0.9 1.6e-27 95.9 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EFX02715.1 - 4.7e-41 140.2 3.4 8.6e-41 139.3 3.4 1.5 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EFX02715.1 - 8.9e-17 61.0 0.1 2.3e-16 59.7 0.1 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Keratin_2_head PF16208.5 EFX02715.1 - 0.061 13.5 0.1 0.19 11.9 0.1 1.8 1 0 0 1 1 1 0 Keratin type II head SelP_N PF04592.14 EFX02715.1 - 1.3 8.4 12.2 2 7.8 12.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region WHIM1 PF15612.6 EFX02716.1 - 1.7e-07 30.6 0.0 3.5e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Nop14 PF04147.12 EFX02716.1 - 0.015 13.6 23.9 0.026 12.8 23.9 1.3 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 EFX02716.1 - 0.37 10.9 32.2 0.45 10.6 22.2 2.6 2 0 0 2 2 2 0 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 EFX02716.1 - 0.81 9.4 27.3 0.055 13.2 21.2 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein GCIP PF13324.6 EFX02716.1 - 6.4 6.3 15.0 13 5.3 15.0 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Zip PF02535.22 EFX02716.1 - 8.5 5.5 5.1 13 4.9 5.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter zf-Tim10_DDP PF02953.15 EFX02717.1 - 9.5e-17 60.4 2.9 1.3e-16 60.0 2.9 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger LEF-8 PF04941.12 EFX02717.1 - 0.063 11.5 0.2 0.062 11.6 0.2 1.0 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) RNase_P_Rpp14 PF01900.19 EFX02718.1 - 6e-37 126.0 0.0 7.9e-37 125.6 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Suf PF05843.14 EFX02719.1 - 9.7e-08 32.3 6.9 0.057 13.4 0.1 4.0 2 1 0 3 3 3 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EFX02719.1 - 2.7e-06 27.7 8.5 0.33 11.9 0.1 7.2 4 2 3 7 7 7 2 Tetratricopeptide repeat Gmad2 PF10648.9 EFX02719.1 - 0.0081 16.4 0.5 0.37 11.1 0.1 3.2 3 1 1 4 4 4 1 Immunoglobulin-like domain of bacterial spore germination Ketoacyl-synt_C PF02801.22 EFX02720.1 - 1.1e-08 35.1 0.1 2e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 EFX02720.1 - 6.6e-06 25.9 0.1 9.9e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Alpha_kinase PF02816.18 EFX02721.1 - 3.4e-52 177.3 0.0 7.1e-52 176.2 0.0 1.6 1 1 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.6 EFX02721.1 - 3.6e-13 50.1 0.9 8.1e-13 49.0 0.1 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFX02721.1 - 5.6e-06 26.7 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain TssR PF17643.1 EFX02721.1 - 0.054 11.4 0.0 0.082 10.8 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssR UPRTase PF14681.6 EFX02722.1 - 1.2e-78 263.3 0.0 1.4e-78 263.1 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFX02722.1 - 0.00068 19.2 0.0 0.0014 18.1 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 EFX02722.1 - 0.18 11.8 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl synthetase-associated domain UCH_1 PF13423.6 EFX02723.1 - 7.7e-35 121.0 0.0 5e-33 115.1 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 EFX02723.1 - 3.8e-11 43.0 0.0 1.1e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Utp21 PF04192.12 EFX02723.1 - 0.038 13.5 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain Aa_trans PF01490.18 EFX02724.1 - 4e-77 259.6 4.3 4.7e-77 259.4 4.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PTPRCAP PF15713.5 EFX02724.1 - 0.0067 16.7 0.9 0.016 15.5 0.9 1.6 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated Astro_capsid_p PF12226.8 EFX02724.1 - 1 8.4 2.2 1.5 7.9 2.2 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sugar_tr PF00083.24 EFX02725.1 - 9.9e-134 446.6 32.0 1.1e-133 446.4 32.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX02725.1 - 4.4e-21 75.2 47.9 1.7e-12 46.9 20.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SirB PF04247.12 EFX02725.1 - 0.014 15.5 6.6 0.21 11.7 1.0 3.1 3 0 0 3 3 3 0 Invasion gene expression up-regulator, SirB DUF3605 PF12239.8 EFX02726.1 - 1.5e-55 187.7 0.0 1.8e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) DHHC PF01529.20 EFX02727.1 - 1.3e-32 112.8 13.7 1.3e-32 112.8 13.7 2.4 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EFX02727.1 - 1.1e-24 86.8 0.0 2.1e-12 47.4 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX02727.1 - 8e-23 80.5 0.7 3.5e-07 30.7 0.3 4.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX02727.1 - 4.4e-22 77.8 0.0 7.9e-07 29.2 0.0 4.7 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFX02727.1 - 7e-20 70.5 0.1 0.00014 22.2 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EFX02727.1 - 1.4e-19 68.1 0.6 3.2e-06 27.1 0.0 6.0 5 0 0 5 5 5 4 Ankyrin repeat Spo12 PF05032.12 EFX02728.1 - 1.5e-15 56.8 1.0 2.6e-15 56.0 1.0 1.4 1 0 0 1 1 1 1 Spo12 family p450 PF00067.22 EFX02729.1 - 4.1e-69 233.5 0.0 5.5e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1467 PF07330.12 EFX02729.1 - 0.1 12.5 0.5 20 5.2 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1467) tRNA-synt_2 PF00152.20 EFX02730.1 - 1.2e-80 270.9 0.0 1.7e-80 270.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFX02730.1 - 9.7e-08 31.9 0.0 1.8e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4023 PF13215.6 EFX02730.1 - 0.062 13.3 2.6 0.13 12.3 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) tRNA_anti_2 PF13742.6 EFX02730.1 - 0.096 12.9 0.0 0.28 11.4 0.0 1.7 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain PFK PF00365.20 EFX02731.1 - 9.8e-187 619.0 0.8 1.6e-103 346.0 0.9 2.1 2 0 0 2 2 2 2 Phosphofructokinase Tau95_N PF17682.1 EFX02731.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Tau95 Triple barrel domain PLDc_2 PF13091.6 EFX02733.1 - 6.3e-18 64.9 0.0 1.9e-06 27.8 0.0 4.1 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 EFX02733.1 - 1.8e-12 46.8 1.6 2.3e-05 24.4 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif tRNA-synt_1d PF00750.19 EFX02734.1 - 3.9e-84 282.6 2.0 4.2e-82 275.9 2.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFX02734.1 - 3.9e-27 94.8 0.0 1.3e-26 93.1 0.0 2.0 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFX02734.1 - 2.7e-05 24.7 0.0 8.3e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Iso_dh PF00180.20 EFX02736.1 - 9e-98 327.6 0.0 1e-97 327.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 EFX02736.1 - 0.035 13.9 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 Sporozoite_P67 PF05642.11 EFX02737.1 - 8.4 4.3 18.3 11 3.9 18.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen G-patch_2 PF12656.7 EFX02738.1 - 7.3e-20 70.8 0.3 7.3e-20 70.8 0.3 3.0 4 0 0 4 4 4 1 G-patch domain MIP PF00230.20 EFX02739.1 - 2.6e-55 187.6 9.0 3e-55 187.4 9.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF92 PF01940.16 EFX02740.1 - 6e-86 287.7 0.6 7.3e-86 287.4 0.6 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 SNF2_N PF00176.23 EFX02741.1 - 4.5e-67 226.2 0.0 6.4e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX02741.1 - 1.1e-12 48.3 0.0 4.1e-12 46.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFX02741.1 - 0.00025 20.9 0.0 0.00054 19.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 EFX02741.1 - 0.00071 19.5 9.5 0.0015 18.4 9.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain HIRAN PF08797.11 EFX02741.1 - 0.0012 18.7 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain zf-C3HC4_3 PF13920.6 EFX02741.1 - 0.0037 17.1 8.1 0.035 14.0 5.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EFX02741.1 - 0.01 15.9 0.0 0.035 14.1 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EFX02741.1 - 0.11 12.3 9.5 0.27 11.1 9.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFX02741.1 - 0.16 12.3 7.2 0.53 10.6 7.2 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFX02741.1 - 0.29 11.5 10.4 1.1 9.6 10.4 2.1 1 1 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 EFX02741.1 - 2.4 8.3 8.3 5.8 7.0 8.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 EFX02741.1 - 5.6 6.9 11.3 20 5.1 9.6 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Syja_N PF02383.18 EFX02742.1 - 2.8e-75 253.6 0.0 5.8e-75 252.6 0.0 1.5 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.23 EFX02742.1 - 1.5e-08 34.5 0.1 2.8e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HAD_2 PF13419.6 EFX02743.1 - 3.9e-10 40.1 0.0 5.7e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFX02743.1 - 1e-07 32.5 0.0 6.6e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX02743.1 - 0.00015 21.8 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.7 EFX02743.1 - 0.0042 16.9 0.0 0.18 11.6 0.0 2.1 2 0 0 2 2 2 1 Acid Phosphatase Glyco_hydro81C PF17652.1 EFX02744.1 - 2.5e-154 513.7 0.0 3.4e-154 513.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EFX02744.1 - 5.7e-93 311.6 0.0 8.4e-93 311.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain DnaJ PF00226.31 EFX02744.1 - 4.9e-19 68.2 0.2 8.8e-19 67.4 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Stn1 PF10451.9 EFX02744.1 - 1.8e-10 40.3 0.0 6.8e-10 38.3 0.0 1.8 1 1 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 EFX02744.1 - 0.00096 19.1 0.2 0.0018 18.2 0.2 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Bromo_TP PF07524.13 EFX02745.1 - 1.7e-15 56.8 0.1 2.9e-15 56.0 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.9 EFX02745.1 - 9.7e-11 42.1 10.7 1.9e-06 28.3 1.3 4.0 3 0 0 3 3 3 2 Transcription factor TFIID complex subunit 8 C-term Peptidase_C12 PF01088.21 EFX02746.1 - 2.5e-43 148.3 0.0 3.1e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Prenyltransf PF01255.19 EFX02747.1 - 0.017 14.7 0.0 0.72 9.3 0.0 2.2 2 0 0 2 2 2 0 Putative undecaprenyl diphosphate synthase ketoacyl-synt PF00109.26 EFX02748.1 - 1.5e-69 234.4 0.1 2.5e-69 233.7 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFX02748.1 - 1.4e-45 156.2 0.1 4e-45 154.7 0.1 1.8 2 0 0 2 2 2 1 Acyl transferase domain SAT PF16073.5 EFX02748.1 - 7.5e-29 101.2 0.3 2.7e-28 99.3 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 EFX02748.1 - 1.5e-10 41.3 0.1 4.1e-10 39.9 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ketoacyl-synt_C PF02801.22 EFX02748.1 - 2.6e-06 27.4 0.0 6.9e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EFX02748.1 - 8.2e-06 25.4 0.0 1.8e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EFX02748.1 - 1.8e-05 25.1 0.0 4.6e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension LRR_1 PF00560.33 EFX02749.1 - 6.4e-05 23.0 10.1 12 6.9 0.0 8.4 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_4 PF12799.7 EFX02749.1 - 0.0014 18.9 16.3 0.22 12.0 3.6 5.8 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) FA_hydroxylase PF04116.13 EFX02750.1 - 1.3e-21 77.3 12.1 1.3e-21 77.3 12.1 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TFIIS_C PF01096.18 EFX02751.1 - 2e-16 59.5 2.6 2e-16 59.5 2.6 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EFX02751.1 - 4.7e-05 23.2 2.7 4.7e-05 23.2 2.7 2.8 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit zinc_ribbon_2 PF13240.6 EFX02751.1 - 0.0052 16.5 11.9 2 8.3 0.1 3.8 4 0 0 4 4 4 3 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EFX02751.1 - 0.0077 16.1 9.9 0.059 13.3 1.5 2.5 2 0 0 2 2 2 2 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 EFX02751.1 - 0.014 14.9 9.1 1.5 8.4 0.1 3.4 3 1 1 4 4 4 0 TFIIB zinc-binding Nudix_N_2 PF14803.6 EFX02751.1 - 0.035 14.0 4.3 0.035 14.0 4.3 3.0 3 0 0 3 3 3 0 Nudix N-terminal Zn-ribbon_8 PF09723.10 EFX02751.1 - 0.041 14.0 13.7 0.099 12.8 0.2 2.9 3 0 0 3 3 3 0 Zinc ribbon domain PAS PF00989.25 EFX02751.1 - 0.047 13.7 0.0 0.06 13.3 0.0 1.1 1 0 0 1 1 1 0 PAS fold UCH_1 PF13423.6 EFX02751.1 - 0.078 12.6 3.6 0.083 12.5 3.6 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase HypA PF01155.19 EFX02751.1 - 0.11 12.5 9.7 1.2 9.2 1.0 2.8 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Gmx_para_CXXCG PF09535.10 EFX02751.1 - 0.13 11.5 3.7 2.5 7.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (Gmx_para_CXXCG) zf-C2HC_2 PF13913.6 EFX02751.1 - 0.14 12.1 1.3 0.14 12.1 1.3 2.9 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Lar_restr_allev PF14354.6 EFX02751.1 - 0.18 12.2 11.7 0.21 12.0 0.6 3.1 2 1 0 2 2 2 0 Restriction alleviation protein Lar DUF1922 PF09082.10 EFX02751.1 - 0.82 10.0 8.0 24 5.3 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1922) Zn_ribbon_SprT PF17283.2 EFX02751.1 - 1.7 8.7 14.9 0.28 11.1 2.6 3.2 3 0 0 3 3 3 0 SprT-like zinc ribbon domain DUF3797 PF12677.7 EFX02751.1 - 1.7 8.6 6.0 0.46 10.4 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3797) zf_UBZ PF18439.1 EFX02751.1 - 4 7.1 8.5 10 5.8 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-ribbon_3 PF13248.6 EFX02751.1 - 6.4 6.3 11.8 2.7 7.5 0.2 3.6 4 0 0 4 4 4 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EFX02751.1 - 9.6 7.0 11.1 3.7 8.4 4.3 2.6 1 1 1 2 2 2 0 zinc-ribbon family ParA PF10609.9 EFX02752.1 - 7.4e-97 323.6 0.0 8.8e-97 323.4 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFX02752.1 - 4.6e-08 33.2 0.0 1.4e-07 31.7 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFX02752.1 - 0.00025 21.0 0.0 0.0014 18.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EFX02752.1 - 0.00029 20.1 0.4 0.0013 18.0 0.2 2.0 1 1 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 EFX02752.1 - 0.0065 16.3 0.0 1.8 8.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EFX02752.1 - 0.0093 15.9 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 EFX02752.1 - 0.0099 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EFX02752.1 - 0.032 13.8 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 EFX02752.1 - 0.046 13.0 0.0 0.12 11.6 0.0 1.7 1 1 0 1 1 1 0 ATPase MipZ AAA_16 PF13191.6 EFX02752.1 - 0.066 13.6 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EFX02752.1 - 0.091 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zn_Tnp_IS1595 PF12760.7 EFX02752.1 - 0.093 12.7 0.1 0.34 10.9 0.1 1.9 1 0 0 1 1 1 0 Transposase zinc-ribbon domain RNA_helicase PF00910.22 EFX02752.1 - 0.11 12.8 0.1 0.27 11.6 0.1 1.6 1 1 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 EFX02752.1 - 0.15 11.2 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain CLP1_P PF16575.5 EFX02752.1 - 0.18 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 EFX02752.1 - 0.21 11.2 0.0 0.58 9.7 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EFX02752.1 - 0.21 11.0 0.0 2.6 7.4 0.0 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ HGTP_anticodon2 PF12745.7 EFX02753.1 - 2.4e-85 286.2 0.3 2.6e-84 282.9 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EFX02753.1 - 6.7e-69 232.2 0.0 1.7e-34 119.4 0.0 3.9 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02753.1 - 4e-39 134.5 0.0 1.5e-18 67.1 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase tRNA-synt_His PF13393.6 EFX02753.1 - 1.7e-16 60.4 0.7 3.1e-16 59.6 0.0 1.8 2 0 0 2 2 2 1 Histidyl-tRNA synthetase RWD PF05773.22 EFX02753.1 - 2e-14 53.8 0.0 4.1e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 RWD domain APH PF01636.23 EFX02753.1 - 1e-05 25.6 4.5 0.13 12.2 0.0 3.4 3 0 0 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFX02753.1 - 0.00013 20.9 2.1 0.057 12.2 0.0 3.3 4 0 0 4 4 4 2 Fungal protein kinase FTA2 PF13095.6 EFX02753.1 - 0.0046 16.6 0.0 0.15 11.6 0.0 3.0 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFX02753.1 - 0.032 13.6 0.1 3.5 6.9 0.0 2.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFX02753.1 - 0.059 12.7 0.0 0.41 9.9 0.0 2.3 2 0 0 2 2 2 0 Kinase-like zf-CCCH PF00642.24 EFX02754.1 - 1.2e-08 34.7 18.5 2.9e-07 30.2 2.5 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EFX02754.1 - 0.0014 18.4 0.0 0.003 17.4 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EFX02754.1 - 0.0028 18.3 2.3 0.48 11.1 0.2 2.3 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EFX02754.1 - 0.0057 16.7 3.3 0.0057 16.7 3.3 3.3 3 0 0 3 3 3 1 Zinc finger domain SCRG1 PF15224.6 EFX02754.1 - 0.062 13.4 3.8 0.31 11.2 0.1 2.4 2 0 0 2 2 2 0 Scrapie-responsive protein 1 zf-CCCH_3 PF15663.5 EFX02754.1 - 0.31 11.3 5.6 0.18 12.1 0.7 2.4 2 1 0 2 2 2 0 Zinc-finger containing family Tachystatin_B PF11478.8 EFX02754.1 - 5.1 7.1 11.9 0.19 11.7 3.1 2.7 2 1 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B NAD_binding_10 PF13460.6 EFX02755.1 - 2.8e-07 30.6 1.6 9.1e-07 28.9 1.6 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFX02755.1 - 6.1e-06 25.9 0.0 1.1e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFX02755.1 - 2.1e-05 24.2 0.4 0.00011 21.8 0.4 1.9 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 EFX02755.1 - 0.03 13.5 0.3 5.3 6.1 0.0 2.5 2 1 1 3 3 3 0 Male sterility protein PA PF02225.22 EFX02755.1 - 0.33 11.0 1.6 0.65 10.1 0.3 2.1 2 1 0 2 2 2 0 PA domain COX5A PF02284.16 EFX02757.1 - 1.1e-40 137.8 0.2 1.5e-40 137.4 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va PS-DH PF14765.6 EFX02758.1 - 5.9e-71 239.1 2.7 1.4e-70 237.9 2.7 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EFX02758.1 - 6.1e-66 222.6 0.0 2.1e-65 220.8 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFX02758.1 - 2.8e-51 174.9 4.4 5.3e-51 174.0 4.4 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFX02758.1 - 3.2e-51 173.8 1.8 9.4e-51 172.3 1.8 1.9 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 EFX02758.1 - 1.1e-36 125.4 2.1 1.4e-36 125.1 0.2 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EFX02758.1 - 3.9e-22 78.9 0.1 2.3e-19 70.0 0.0 3.6 3 0 0 3 3 3 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EFX02758.1 - 2.1e-14 53.9 0.0 6.2e-14 52.4 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EFX02758.1 - 1.9e-12 47.7 0.1 1.2e-11 45.1 0.1 2.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02758.1 - 5.4e-12 46.2 0.1 3e-11 43.8 0.1 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX02758.1 - 7.5e-12 45.4 0.0 1.9e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EFX02758.1 - 2.8e-08 33.4 0.1 9.8e-08 31.7 0.1 1.9 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.25 EFX02758.1 - 1.8e-06 28.2 0.5 5.3e-06 26.7 0.5 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 EFX02758.1 - 7.3e-06 25.8 0.0 2e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX02758.1 - 7e-05 22.3 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ACP_syn_III PF08545.10 EFX02758.1 - 0.0034 17.2 0.2 0.013 15.3 0.2 2.1 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_2 PF00891.18 EFX02758.1 - 0.036 13.4 0.0 0.1 11.8 0.0 1.7 1 0 0 1 1 1 0 O-methyltransferase domain DUF4716 PF15837.5 EFX02758.1 - 0.08 13.0 0.5 0.24 11.5 0.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4716) 3Beta_HSD PF01073.19 EFX02758.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_24 PF13578.6 EFX02758.1 - 0.13 13.3 6.4 0.92 10.6 0.1 4.4 3 0 0 3 3 2 0 Methyltransferase domain GDP_Man_Dehyd PF16363.5 EFX02758.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Thiolase_N PF00108.23 EFX02758.1 - 0.14 11.5 5.5 0.018 14.4 0.4 2.0 2 0 0 2 2 2 0 Thiolase, N-terminal domain Snf7 PF03357.21 EFX02759.1 - 1.6e-35 122.3 18.1 2e-35 121.9 17.4 1.4 2 0 0 2 2 2 1 Snf7 CCAP PF11105.8 EFX02759.1 - 0.036 14.0 0.6 0.067 13.1 0.6 1.5 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a Ist1 PF03398.14 EFX02759.1 - 0.49 10.3 6.5 0.83 9.6 6.5 1.4 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway PspA_IM30 PF04012.12 EFX02759.1 - 1 8.9 15.8 2.6 7.6 4.8 2.1 1 1 0 2 2 2 0 PspA/IM30 family GPI2 PF06432.11 EFX02760.1 - 3.4e-131 436.8 0.1 2e-129 431.0 0.0 2.0 2 0 0 2 2 2 2 Phosphatidylinositol N-acetylglucosaminyltransferase Ank_5 PF13857.6 EFX02761.1 - 6.4e-12 45.5 0.2 3.4e-08 33.6 0.1 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX02761.1 - 5.8e-11 42.8 0.0 1.5e-10 41.5 0.0 1.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX02761.1 - 3.3e-07 30.1 0.1 0.0096 16.4 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFX02761.1 - 5.2e-07 29.8 2.0 0.00011 22.5 0.4 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFX02761.1 - 4.7e-06 27.1 1.0 0.002 18.7 0.2 2.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Porphobil_deamC PF03900.15 EFX02761.1 - 0.085 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Porphobilinogen deaminase, C-terminal domain TMEM234 PF10639.9 EFX02762.1 - 3.6e-34 117.3 0.1 7.6e-34 116.2 0.1 1.5 1 1 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 EFX02762.1 - 0.002 18.3 4.8 0.1 12.8 4.8 2.2 1 1 0 1 1 1 1 EamA-like transporter family DinB_2 PF12867.7 EFX02763.1 - 0.21 12.1 1.0 0.5 10.9 1.0 1.7 1 1 0 1 1 1 0 DinB superfamily ECM11 PF15463.6 EFX02764.1 - 9.8e-45 152.4 5.0 9.8e-45 152.4 5.0 2.0 2 1 0 2 2 2 1 Extracellular mutant protein 11 NACHT PF05729.12 EFX02765.1 - 0.00015 21.7 0.1 0.0003 20.8 0.1 1.5 1 0 0 1 1 1 1 NACHT domain ATPase PF06745.13 EFX02765.1 - 0.0072 15.7 2.5 0.015 14.7 0.1 2.2 1 1 1 2 2 2 1 KaiC NmrA PF05368.13 EFX02766.1 - 2.3e-78 263.0 0.0 3.1e-78 262.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX02766.1 - 6e-07 29.5 0.1 2.2e-05 24.4 0.1 2.2 1 1 0 1 1 1 1 NAD(P)H-binding DUF3798 PF12683.7 EFX02766.1 - 0.0079 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) GLTT PF01744.20 EFX02766.1 - 0.2 11.5 3.0 0.66 9.8 3.0 1.9 1 0 0 1 1 1 0 GLTT repeat (6 copies) XRN_M PF17846.1 EFX02767.1 - 5e-98 328.9 1.7 7.5e-96 321.8 3.9 2.6 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 EFX02767.1 - 6e-96 320.5 0.0 1e-95 319.8 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EFX02767.1 - 4.6e-71 238.6 0.1 8.1e-71 237.8 0.1 1.4 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EFX02767.1 - 2.6e-32 110.9 0.0 7.6e-32 109.4 0.0 1.9 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EFX02767.1 - 1.2e-24 86.2 0.7 2.6e-24 85.1 0.7 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EFX02767.1 - 7.3e-05 22.8 0.0 0.00019 21.5 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 Acetyltransf_6 PF13480.7 EFX02767.1 - 0.1 12.8 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain COesterase PF00135.28 EFX02769.1 - 1.7e-49 169.1 0.0 2.5e-49 168.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX02769.1 - 3e-06 27.2 0.1 0.095 12.5 0.1 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold NUDIX PF00293.28 EFX02770.1 - 2.9e-10 40.3 0.4 5.1e-10 39.5 0.1 1.6 2 0 0 2 2 2 1 NUDIX domain SelB-wing_3 PF09107.11 EFX02770.1 - 0.12 12.1 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Oxysterol_BP PF01237.18 EFX02771.1 - 9.3e-104 347.2 0.0 1.6e-103 346.4 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein DNA_pol_E_B PF04042.16 EFX02771.1 - 3.7e-64 215.9 0.0 1.7e-63 213.8 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B PH_8 PF15409.6 EFX02771.1 - 6.1e-36 122.6 0.4 2.4e-35 120.6 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EFX02771.1 - 8.1e-06 26.3 0.0 1.8e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 PH domain SLS PF14611.6 EFX02772.1 - 1.6e-47 162.2 0.2 2.5e-47 161.6 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator BAR_2 PF10455.9 EFX02773.1 - 4.9e-57 193.3 0.9 7.7e-57 192.6 0.9 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EFX02773.1 - 6.7e-20 71.8 5.0 1.1e-18 67.8 5.0 2.3 1 1 0 1 1 1 1 BAR domain LSM PF01423.22 EFX02773.1 - 3e-14 52.5 0.0 5.7e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 LSM domain PPR_2 PF13041.6 EFX02773.1 - 0.00094 19.3 0.0 4.5 7.6 0.0 4.4 4 0 0 4 4 4 1 PPR repeat family PPR PF01535.20 EFX02773.1 - 0.0017 18.5 0.1 4.3 7.8 0.0 4.7 3 0 0 3 3 3 1 PPR repeat BAR_3 PF16746.5 EFX02773.1 - 0.0063 16.2 0.7 0.0063 16.2 0.7 2.1 3 0 0 3 3 3 1 BAR domain of APPL family PPR_long PF17177.4 EFX02773.1 - 0.045 13.1 0.0 0.16 11.3 0.0 1.9 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EFX02773.1 - 0.17 12.0 0.0 2 8.5 0.0 2.6 2 1 1 3 3 3 0 Pentatricopeptide repeat domain RIBIOP_C PF04950.12 EFX02774.1 - 3.6e-91 305.6 0.2 3.6e-91 305.6 0.2 1.9 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFX02774.1 - 3.3e-28 97.6 0.0 1e-27 96.0 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_16 PF13191.6 EFX02774.1 - 1.5e-05 25.4 0.1 9.4e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFX02774.1 - 7.3e-05 23.1 0.3 0.00029 21.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFX02774.1 - 0.00061 20.2 0.1 0.0019 18.6 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFX02774.1 - 0.00074 20.0 0.2 0.0046 17.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 EFX02774.1 - 0.00097 19.1 0.0 0.0024 17.8 0.0 1.7 1 1 0 1 1 1 1 NACHT domain GTP_EFTU PF00009.27 EFX02774.1 - 0.0014 18.2 0.0 0.14 11.6 0.0 2.5 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFX02774.1 - 0.0015 18.5 0.0 0.0065 16.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EFX02774.1 - 0.0021 18.6 2.3 0.046 14.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EFX02774.1 - 0.0028 17.8 1.4 0.0099 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EFX02774.1 - 0.0057 16.4 0.0 0.016 14.9 0.0 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 EFX02774.1 - 0.0062 16.9 0.0 0.02 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFX02774.1 - 0.009 16.0 0.2 0.052 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFX02774.1 - 0.013 14.7 0.0 0.037 13.2 0.0 1.7 2 0 0 2 2 1 0 NB-ARC domain cobW PF02492.19 EFX02774.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 EFX02774.1 - 0.031 14.6 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Ploopntkinase3 PF18751.1 EFX02774.1 - 0.049 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 NTPase_1 PF03266.15 EFX02774.1 - 0.057 13.3 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 EFX02774.1 - 0.059 13.4 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EFX02774.1 - 0.06 13.6 0.0 0.06 13.6 0.0 2.8 4 0 0 4 4 2 0 AAA domain AAA_25 PF13481.6 EFX02774.1 - 0.077 12.6 0.2 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFX02774.1 - 0.11 12.0 0.0 0.32 10.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EFX02774.1 - 0.11 12.3 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Roc PF08477.13 EFX02774.1 - 0.13 12.5 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_11 PF13086.6 EFX02774.1 - 0.39 10.5 0.0 0.39 10.5 0.0 3.4 3 1 0 3 3 2 0 AAA domain AAA_23 PF13476.6 EFX02774.1 - 2.5 8.5 0.0 2.5 8.5 0.0 4.1 4 0 0 4 4 3 0 AAA domain Fungal_trans PF04082.18 EFX02775.1 - 0.022 13.8 0.0 0.038 13.0 0.0 1.4 1 1 0 1 1 1 0 Fungal specific transcription factor domain MFS_1 PF07690.16 EFX02776.1 - 3.9e-27 95.1 35.5 3.9e-27 95.1 35.5 2.6 4 0 0 4 4 4 1 Major Facilitator Superfamily Nucleopor_Nup85 PF07575.13 EFX02776.1 - 6.8e-12 44.7 0.1 0.00037 19.2 0.0 3.1 3 0 0 3 3 3 3 Nup85 Nucleoporin cIII PF08134.11 EFX02776.1 - 0.0079 15.9 0.3 0.026 14.3 0.3 1.8 1 0 0 1 1 1 1 cIII protein family PAXIP1_C PF15364.6 EFX02776.1 - 0.11 12.8 11.1 0.02 15.2 6.3 2.2 1 1 1 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein MR_MLE_C PF13378.6 EFX02777.1 - 3.2e-58 196.9 0.1 4.7e-58 196.4 0.1 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFX02777.1 - 0.0051 17.0 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 EFX02777.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Ferric_reduct PF01794.19 EFX02778.1 - 2.9e-15 56.5 12.3 2.9e-15 56.5 12.3 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EFX02778.1 - 6.1e-14 52.0 0.0 1.5e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EFX02778.1 - 7e-13 49.0 0.0 1.1e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain HDA2-3 PF11496.8 EFX02779.1 - 0.00022 20.5 0.0 0.015 14.5 0.0 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 E2R135 PF11570.8 EFX02779.1 - 0.0012 19.1 1.7 0.0012 19.1 1.7 2.1 2 0 0 2 2 2 1 Coiled-coil receptor-binding R-domain of colicin E2 Chromo PF00385.24 EFX02779.1 - 0.016 15.1 0.1 0.034 14.0 0.1 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Spt20 PF12090.8 EFX02779.1 - 8.1 6.0 23.2 0.16 11.6 10.3 2.4 2 0 0 2 2 2 0 Spt20 family DUF775 PF05603.12 EFX02779.1 - 9.7 5.7 9.3 0.27 10.8 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Sec2p PF06428.11 EFX02780.1 - 7.5e-13 48.3 13.5 5.3e-11 42.3 9.4 2.6 2 0 0 2 2 2 2 GDP/GTP exchange factor Sec2p Exonuc_VII_L PF02601.15 EFX02780.1 - 0.15 11.6 15.3 0.79 9.2 14.8 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit APG6_N PF17675.1 EFX02780.1 - 0.26 11.8 0.1 0.26 11.8 0.1 3.3 2 1 1 3 3 3 0 Apg6 coiled-coil region Atg14 PF10186.9 EFX02780.1 - 0.36 9.9 17.3 6.3 5.8 0.1 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 UvrD-helicase PF00580.21 EFX02780.1 - 0.64 9.5 8.7 1.1 8.7 8.7 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain TFIIA PF03153.13 EFX02780.1 - 0.77 9.7 12.1 0.99 9.3 12.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YabA PF06156.13 EFX02780.1 - 2.5 8.8 6.3 33 5.2 0.0 3.0 2 1 0 2 2 2 0 Initiation control protein YabA YlqD PF11068.8 EFX02780.1 - 5.7 7.3 16.6 2 8.8 8.2 2.6 2 1 0 2 2 2 0 YlqD protein Spc7 PF08317.11 EFX02780.1 - 6.4 5.6 24.1 7.7 5.3 0.4 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein IGPS PF00218.21 EFX02781.1 - 2.1e-96 322.0 0.0 3.3e-96 321.4 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EFX02781.1 - 2.7e-46 157.8 0.0 4.8e-41 140.7 0.0 2.6 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EFX02781.1 - 1.4e-45 155.4 0.0 2.5e-45 154.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFX02781.1 - 3.4e-05 23.7 0.2 0.00031 20.6 0.2 2.3 1 1 0 1 1 1 1 Peptidase C26 Peripla_BP_2 PF01497.18 EFX02781.1 - 0.0051 16.4 0.0 0.0099 15.5 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein DUF3818 PF12825.7 EFX02781.1 - 0.16 10.9 0.0 0.5 9.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) TUG-UBL1 PF11470.8 EFX02782.1 - 2.3e-21 75.7 0.0 5e-21 74.7 0.0 1.6 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 EFX02782.1 - 0.00089 19.4 0.0 0.003 17.7 0.0 1.9 2 0 0 2 2 2 1 UBX domain S4 PF01479.25 EFX02783.1 - 2.1e-14 52.9 0.0 5e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 EFX02783.1 - 0.19 11.6 0.0 0.4 10.5 0.0 1.5 1 0 0 1 1 1 0 S4 domain bZIP_1 PF00170.21 EFX02784.1 - 0.013 15.6 6.6 0.026 14.6 6.6 1.4 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 EFX02784.1 - 0.67 10.1 10.1 0.56 10.3 7.5 2.1 1 1 1 2 2 2 0 Basic region leucine zipper AflR PF08493.10 EFX02785.1 - 2.7e-07 30.4 19.0 5.3e-07 29.4 18.0 2.0 1 1 1 2 2 2 1 Aflatoxin regulatory protein Sec63 PF02889.16 EFX02787.1 - 2.3e-124 413.6 0.0 9.1e-76 254.4 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFX02787.1 - 6.2e-49 166.1 0.0 5.2e-26 91.5 0.2 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EFX02787.1 - 9.7e-19 68.0 0.0 2.3e-09 37.5 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFX02787.1 - 5.4e-16 58.9 0.0 1.9e-06 28.2 0.0 5.1 4 3 0 4 4 4 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 EFX02787.1 - 1e-06 28.6 0.1 0.062 13.0 0.2 3.0 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFX02787.1 - 7.3e-06 26.3 0.6 0.43 10.9 0.0 3.8 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EFX02787.1 - 4.3e-05 23.9 0.2 0.0075 16.6 0.3 2.6 2 0 0 2 2 2 1 AAA domain Helicase_PWI PF18149.1 EFX02787.1 - 0.00015 21.9 0.0 0.00042 20.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal helicase PWI domain T2SSE PF00437.20 EFX02787.1 - 0.034 13.2 0.0 1.8 7.6 0.0 2.9 3 0 0 3 3 3 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EFX02787.1 - 0.15 11.8 0.3 29 4.3 0.0 4.0 5 0 0 5 5 5 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 EFX02788.1 - 2.3e-08 34.1 0.2 7.3e-07 29.3 0.2 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFX02788.1 - 5.5e-06 25.8 0.7 0.02 14.2 0.1 2.8 3 0 0 3 3 3 2 AIG1 family RsgA_GTPase PF03193.16 EFX02788.1 - 7.2e-06 26.0 0.1 2.5e-05 24.2 0.1 1.9 1 1 0 1 1 1 1 RsgA GTPase Septin PF00735.18 EFX02788.1 - 0.00066 19.0 0.2 0.0025 17.1 0.2 1.9 1 1 0 1 1 1 1 Septin AAA_16 PF13191.6 EFX02788.1 - 0.0008 19.8 1.0 0.057 13.8 0.0 3.1 3 0 0 3 3 2 1 AAA ATPase domain GTP_EFTU PF00009.27 EFX02788.1 - 0.0011 18.6 0.0 0.0033 17.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFX02788.1 - 0.0013 18.8 2.0 0.011 15.8 0.9 3.0 2 1 0 2 2 2 1 Dynamin family T2SSE PF00437.20 EFX02788.1 - 0.0031 16.6 0.0 0.0072 15.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein IIGP PF05049.13 EFX02788.1 - 0.0069 15.5 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 EFX02788.1 - 0.0087 15.8 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFX02788.1 - 0.0098 15.3 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF87 PF01935.17 EFX02788.1 - 0.027 14.5 1.6 0.085 12.9 0.1 2.5 3 0 0 3 3 3 0 Helicase HerA, central domain Sigma54_activat PF00158.26 EFX02788.1 - 0.037 13.7 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EFX02788.1 - 0.046 13.4 0.0 0.13 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFX02788.1 - 0.047 14.0 0.0 0.55 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFX02788.1 - 0.047 14.2 0.2 0.29 11.7 0.0 2.4 2 1 1 3 3 2 0 ABC transporter AAA_10 PF12846.7 EFX02788.1 - 0.054 12.4 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.22 EFX02788.1 - 0.061 13.7 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EFX02788.1 - 0.086 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Spore_IV_A PF09547.10 EFX02788.1 - 0.087 11.7 0.2 0.34 9.8 0.0 2.0 3 0 0 3 3 3 0 Stage IV sporulation protein A (spore_IV_A) DUF2205 PF10224.9 EFX02788.1 - 0.13 12.3 0.2 0.97 9.5 0.2 2.4 2 0 0 2 2 2 0 Short coiled-coil protein AAA_23 PF13476.6 EFX02788.1 - 0.19 12.2 9.8 41 4.6 9.8 2.7 1 1 0 1 1 1 0 AAA domain POM121 PF15229.6 EFX02789.1 - 0.023 14.4 1.9 0.034 13.8 1.9 1.2 1 0 0 1 1 1 0 POM121 family ABC_tran_CTD PF16326.5 EFX02790.1 - 0.00024 21.3 2.1 0.00024 21.3 2.1 6.0 4 3 1 5 5 5 1 ABC transporter C-terminal domain CorA PF01544.18 EFX02790.1 - 0.012 14.9 2.4 0.012 14.9 2.4 2.1 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein GlcNAc PF11397.8 EFX02790.1 - 0.044 13.2 0.2 0.044 13.2 0.2 1.9 2 0 0 2 2 2 0 Glycosyltransferase (GlcNAc) HtaA PF04213.13 EFX02790.1 - 1.2 9.6 4.6 0.22 12.0 0.3 2.0 2 1 0 2 2 2 0 Htaa Hydrolase_4 PF12146.8 EFX02792.1 - 8.5e-11 41.6 0.1 4.6e-08 32.6 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFX02792.1 - 1.8e-06 27.8 0.1 8.2e-06 25.6 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX02792.1 - 2e-06 28.6 17.7 8.5e-06 26.5 17.7 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family GCIP PF13324.6 EFX02792.1 - 0.0038 16.9 0.1 0.0067 16.1 0.1 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Prenyltrans PF00432.21 EFX02793.1 - 1.1e-30 105.0 25.9 3.4e-08 33.1 0.3 6.2 5 1 1 6 6 6 6 Prenyltransferase and squalene oxidase repeat Kdo PF06293.14 EFX02794.1 - 1.2e-06 28.0 0.1 2e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX02794.1 - 1.6e-05 25.0 0.2 0.0055 16.7 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EFX02794.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EFX02794.1 - 0.048 13.2 0.0 0.46 10.0 0.0 2.0 1 1 1 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.25 EFX02794.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain HIGH_NTase1 PF05636.11 EFX02795.1 - 0.016 14.5 0.2 0.02 14.1 0.2 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase FTA4 PF13093.6 EFX02798.1 - 2.9e-65 220.0 0.8 3.9e-65 219.5 0.8 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2462 PF09495.10 EFX02798.1 - 1.7e-15 57.5 7.2 1.7e-15 57.5 7.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) Lin-8 PF03353.15 EFX02798.1 - 5.9 6.4 6.1 19 4.7 0.0 2.9 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist UQ_con PF00179.26 EFX02799.1 - 3.8e-47 159.5 0.0 4.3e-47 159.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX02799.1 - 0.00024 20.8 0.0 0.0003 20.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFX02799.1 - 0.0077 16.1 0.1 0.015 15.1 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 EFX02799.1 - 0.086 13.1 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain MFS_1 PF07690.16 EFX02800.1 - 3.8e-37 128.1 32.4 3.8e-37 128.1 32.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02800.1 - 2.5e-11 43.1 9.2 2.5e-11 43.1 9.2 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EFX02800.1 - 3.6e-07 29.0 2.4 5.4e-07 28.4 2.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AAA PF00004.29 EFX02801.1 - 3.5e-28 98.7 0.0 1.6e-20 73.9 0.0 3.3 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX02801.1 - 8.4e-05 23.0 2.8 0.02 15.3 0.0 4.2 3 1 1 4 4 4 1 AAA ATPase domain Parvo_NS1 PF01057.17 EFX02801.1 - 0.0007 18.8 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RuvB_N PF05496.12 EFX02801.1 - 0.0019 17.9 0.0 0.0042 16.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 EFX02801.1 - 0.0031 17.3 2.8 0.54 10.1 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_22 PF13401.6 EFX02801.1 - 0.0035 17.6 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFX02801.1 - 0.0073 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.6 EFX02801.1 - 0.0089 15.6 0.7 0.079 12.5 0.0 2.8 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFX02801.1 - 0.018 15.4 0.0 0.078 13.4 0.0 2.2 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EFX02801.1 - 0.019 14.4 0.0 0.052 12.9 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFX02801.1 - 0.026 14.7 0.0 2.4 8.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EFX02801.1 - 0.039 14.5 0.0 0.1 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EFX02801.1 - 0.04 13.2 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 EFX02801.1 - 0.046 13.9 0.2 0.15 12.2 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EFX02801.1 - 0.074 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EFX02801.1 - 0.093 13.0 0.0 0.35 11.1 0.0 2.0 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 EFX02801.1 - 0.1 12.1 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_5 PF07728.14 EFX02801.1 - 0.13 12.3 0.1 0.47 10.5 0.0 2.0 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EFX02801.1 - 0.13 12.6 0.0 0.54 10.7 0.0 2.1 2 0 0 2 2 1 0 AAA domain DUF815 PF05673.13 EFX02801.1 - 0.14 11.3 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) F-box-like PF12937.7 EFX02802.1 - 0.048 13.6 0.4 0.11 12.4 0.4 1.7 1 0 0 1 1 1 0 F-box-like DUF823 PF05689.11 EFX02803.1 - 0.02 14.7 0.2 0.028 14.2 0.2 1.2 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF823) WD40 PF00400.32 EFX02805.1 - 3.3e-10 40.4 14.7 0.0012 19.6 0.1 5.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EFX02805.1 - 9.8e-06 25.1 8.0 2.5e-05 23.8 8.0 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RNB PF00773.19 EFX02806.1 - 3e-55 187.9 0.0 5e-55 187.1 0.0 1.3 1 0 0 1 1 1 1 RNB domain DUF3543 PF12063.8 EFX02807.1 - 1.1e-89 300.2 0.0 1.7e-89 299.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EFX02807.1 - 7.8e-55 186.1 0.0 1.5e-54 185.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02807.1 - 1.6e-36 125.9 0.0 3.7e-36 124.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EFX02807.1 - 0.22 10.4 0.0 0.33 9.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ribosomal_L2_C PF03947.18 EFX02808.1 - 9.4e-42 142.2 4.7 1.6e-41 141.4 4.7 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFX02808.1 - 5.6e-15 55.1 0.1 1.5e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain UCH PF00443.29 EFX02809.1 - 7.8e-37 127.1 0.0 1.1e-36 126.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EFX02809.1 - 6.4e-24 83.5 3.7 1.8e-11 43.7 0.5 2.6 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP_var PF17807.1 EFX02809.1 - 2.6e-22 78.3 1.2 6.4e-22 77.1 0.0 2.2 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EFX02809.1 - 2.7e-19 69.2 19.0 1.1e-18 67.3 1.3 3.6 4 1 0 4 4 4 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EFX02809.1 - 4.1e-19 69.3 0.2 1.8e-17 64.0 0.0 2.8 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase HOIP-UBA PF16678.5 EFX02809.1 - 0.092 12.8 1.9 0.25 11.3 0.1 2.4 3 1 0 3 3 3 0 HOIP UBA domain pair DUF2180 PF09947.9 EFX02809.1 - 1.1 9.3 6.4 26 4.9 0.0 4.2 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) MFS_1 PF07690.16 EFX02810.1 - 5.5e-24 84.7 51.1 1.8e-13 50.2 23.7 2.9 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX02810.1 - 2.7e-09 36.4 32.5 3.4e-06 26.2 11.9 2.4 3 0 0 3 3 3 2 Sugar (and other) transporter Exo_endo_phos PF03372.23 EFX02812.1 - 0.00013 21.5 0.1 0.00024 20.7 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 EFX02812.1 - 0.1 12.9 0.0 0.38 11.1 0.0 1.9 1 0 0 1 1 1 0 Nucleotidyltransferase domain Fungal_trans PF04082.18 EFX02813.1 - 1.3e-20 73.6 0.0 2e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02813.1 - 5.2e-08 32.9 10.7 8.5e-08 32.2 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2OG-FeII_Oxy_3 PF13640.6 EFX02814.1 - 1.7e-09 38.4 0.2 4.4e-09 37.1 0.1 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 EFX02815.1 - 1.5e-08 34.6 14.7 2.5e-08 33.9 14.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Roughex PF06020.11 EFX02815.1 - 8.1 5.4 9.8 20 4.1 9.8 1.6 1 0 0 1 1 1 0 Drosophila roughex protein MIOX PF05153.15 EFX02816.1 - 3.5e-121 403.5 0.1 4.8e-121 403.0 0.1 1.2 1 0 0 1 1 1 1 Myo-inositol oxygenase UBD PF16455.5 EFX02816.1 - 0.069 13.4 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-binding domain LptF_LptG PF03739.14 EFX02816.1 - 0.49 9.2 1.5 0.63 8.8 1.5 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Retrotrans_gag PF03732.17 EFX02816.1 - 0.74 10.1 4.4 1.9 8.8 4.4 1.6 1 1 0 1 1 1 0 Retrotransposon gag protein ABC_membrane PF00664.23 EFX02817.1 - 2.8e-48 165.0 32.4 3.5e-27 95.8 12.1 4.1 3 1 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EFX02817.1 - 6.9e-45 152.9 0.1 1.2e-24 87.3 0.1 2.8 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 EFX02817.1 - 1.4e-05 25.5 0.1 0.012 16.0 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EFX02817.1 - 0.0011 18.2 0.1 0.006 15.9 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.23 EFX02817.1 - 0.002 18.2 1.8 1.1 9.4 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EFX02817.1 - 0.0041 17.0 1.7 0.97 9.2 0.3 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFX02817.1 - 0.028 14.2 2.3 0.85 9.4 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFX02817.1 - 0.046 13.6 2.1 0.52 10.2 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase MeaB PF03308.16 EFX02817.1 - 0.048 12.6 3.0 3.9 6.4 0.1 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_ab PF00006.25 EFX02817.1 - 0.14 11.8 0.0 12 5.5 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.19 EFX02817.1 - 0.17 11.4 0.3 0.39 10.3 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 EFX02817.1 - 0.18 12.0 0.5 7.9 6.7 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SMC_N PF02463.19 EFX02817.1 - 0.27 10.6 4.4 5.1 6.5 0.0 3.1 3 1 1 4 4 4 0 RecF/RecN/SMC N terminal domain TrwB_AAD_bind PF10412.9 EFX02817.1 - 0.56 9.1 2.1 1.7 7.5 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.6 EFX02817.1 - 0.66 10.5 2.3 1.3 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFX02817.1 - 1.3 8.9 3.1 0.56 10.1 0.3 1.8 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 EFX02817.1 - 1.3 9.2 4.1 0.96 9.7 0.0 2.9 4 0 0 4 4 3 0 AAA domain NB-ARC PF00931.22 EFX02817.1 - 2.4 7.3 4.5 7.3 5.7 0.8 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 EFX02817.1 - 2.5 7.8 8.1 3.1 7.5 0.6 3.0 4 0 0 4 4 3 0 AAA domain DUF87 PF01935.17 EFX02817.1 - 3.6 7.6 6.1 22 5.0 0.6 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Dynamin_N PF00350.23 EFX02817.1 - 5.7 7.0 5.8 0.66 10.0 0.5 2.1 2 0 0 2 2 2 0 Dynamin family Na_Ca_ex PF01699.24 EFX02818.1 - 5.1e-41 140.1 36.0 1.3e-20 73.9 16.7 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein PIF1 PF05970.14 EFX02820.1 - 2.5e-56 191.4 0.1 4.7e-42 144.4 0.0 2.3 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EFX02820.1 - 4.3e-17 62.5 0.0 7.8e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX02820.1 - 2.1e-09 37.8 0.0 4.4e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFX02820.1 - 1.8e-06 28.3 0.0 5e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFX02820.1 - 1.4e-05 25.5 0.0 4.2e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 EFX02820.1 - 0.00025 20.8 0.1 0.00065 19.5 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_7 PF12775.7 EFX02820.1 - 0.00028 20.5 0.0 0.00069 19.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EFX02820.1 - 0.00064 20.2 0.0 0.0016 18.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Herpes_Helicase PF02689.14 EFX02820.1 - 0.00082 17.4 0.0 0.0018 16.3 0.0 1.5 2 0 0 2 2 2 1 Helicase SH3_13 PF18335.1 EFX02820.1 - 0.0028 17.5 0.0 0.0073 16.1 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain AAA_5 PF07728.14 EFX02820.1 - 0.0034 17.4 0.1 0.061 13.3 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 EFX02820.1 - 0.0048 17.0 0.0 0.036 14.1 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFX02820.1 - 0.0073 16.7 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.16 EFX02820.1 - 0.014 14.9 0.0 0.035 13.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 EFX02820.1 - 0.025 15.1 0.0 0.15 12.6 0.0 2.3 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 EFX02820.1 - 0.039 13.9 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 EFX02820.1 - 0.039 13.7 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EFX02820.1 - 0.04 13.1 0.0 0.073 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_11 PF13086.6 EFX02820.1 - 0.044 13.6 0.4 0.93 9.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFX02820.1 - 0.069 12.9 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 EFX02820.1 - 0.12 12.5 0.0 0.5 10.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF5605 PF18310.1 EFX02820.1 - 0.12 12.3 0.0 0.46 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5605) DUF815 PF05673.13 EFX02820.1 - 0.12 11.5 0.1 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EFX02820.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Pkinase PF00069.25 EFX02821.1 - 8.4e-32 110.6 0.0 1.6e-17 63.8 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02821.1 - 7e-16 58.3 0.0 4.5e-08 32.7 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase TMEM208_SND2 PF05620.11 EFX02822.1 - 1.2e-52 178.1 0.3 1.3e-52 178.0 0.3 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 5-FTHF_cyc-lig PF01812.20 EFX02823.1 - 3.5e-10 40.0 0.0 4.8e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Questin_oxidase PF14027.6 EFX02824.1 - 6.1e-27 95.1 0.3 7.8e-27 94.7 0.3 1.1 1 0 0 1 1 1 1 Questin oxidase-like Fcf1 PF04900.12 EFX02825.1 - 6.7e-12 45.7 0.1 1.5e-11 44.6 0.1 1.6 1 1 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EFX02825.1 - 0.12 12.7 0.0 0.25 11.6 0.0 1.5 2 0 0 2 2 2 0 PIN like domain DUF4149 PF13664.6 EFX02826.1 - 7.7e-21 74.3 3.2 7.7e-21 74.3 3.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Hat1_N PF10394.9 EFX02827.1 - 1.2e-47 162.1 0.0 2.1e-47 161.4 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.7 EFX02827.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX02827.1 - 0.1 12.8 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family AAA PF00004.29 EFX02828.1 - 1.2e-56 190.7 0.0 2.9e-41 141.0 0.0 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX02828.1 - 1e-08 34.8 0.0 8.9e-08 31.8 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EFX02828.1 - 2.2e-08 34.7 3.6 0.07 13.5 1.3 4.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EFX02828.1 - 6.7e-08 32.6 0.1 0.017 15.2 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFX02828.1 - 1.5e-07 31.7 2.5 0.00031 21.0 0.1 4.0 3 2 0 3 3 2 1 AAA domain NACHT PF05729.12 EFX02828.1 - 8.1e-07 29.1 2.0 0.0046 16.9 0.2 4.2 3 1 1 4 4 4 1 NACHT domain AAA_2 PF07724.14 EFX02828.1 - 1.9e-05 24.9 0.1 0.22 11.6 0.0 4.2 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EFX02828.1 - 3.9e-05 23.9 0.7 0.36 11.1 0.0 3.9 4 1 0 4 4 4 1 AAA domain Mg_chelatase PF01078.21 EFX02828.1 - 0.00012 21.5 0.1 0.52 9.7 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EFX02828.1 - 0.00027 20.7 0.0 0.052 13.3 0.0 3.2 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EFX02828.1 - 0.001 19.1 0.1 0.19 11.7 0.0 3.1 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EFX02828.1 - 0.0011 19.2 0.0 2.4 8.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EFX02828.1 - 0.0017 17.9 0.0 1.4 8.4 0.0 2.7 3 0 0 3 3 2 2 P-loop containing dynein motor region Rad17 PF03215.15 EFX02828.1 - 0.0025 17.8 0.0 0.0096 15.9 0.0 2.0 2 0 0 2 2 1 1 Rad17 P-loop domain AAA_18 PF13238.6 EFX02828.1 - 0.0032 18.0 0.0 0.48 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFX02828.1 - 0.0036 17.7 0.0 3.2 8.2 0.0 2.9 2 0 0 2 2 2 1 RNA helicase NTPase_1 PF03266.15 EFX02828.1 - 0.0049 16.8 0.2 0.32 10.9 0.0 3.1 3 1 1 4 4 3 1 NTPase TniB PF05621.11 EFX02828.1 - 0.0052 16.2 0.1 4.7 6.6 0.0 3.3 2 1 1 3 3 3 1 Bacterial TniB protein AAA_25 PF13481.6 EFX02828.1 - 0.0065 16.1 8.6 5.3 6.6 0.2 4.7 3 2 1 5 5 5 1 AAA domain AAA_30 PF13604.6 EFX02828.1 - 0.011 15.5 0.1 0.34 10.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 EFX02828.1 - 0.017 15.2 0.0 3.2 7.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFX02828.1 - 0.064 13.0 0.0 5.1 6.8 0.0 3.0 2 1 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EFX02828.1 - 0.064 13.0 0.0 6.9 6.4 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 EFX02828.1 - 0.083 13.0 0.0 6.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DAP3 PF10236.9 EFX02828.1 - 0.15 11.2 0.0 2.9 7.0 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.27 EFX02828.1 - 0.18 12.4 0.1 0.92 10.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 EFX02828.1 - 0.27 10.6 2.9 21 4.3 0.1 3.2 2 1 1 3 3 3 0 KaiC DLH PF01738.18 EFX02829.1 - 6.8e-16 58.5 0.0 8.4e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Glyco_hydro_16 PF00722.21 EFX02830.1 - 2.5e-41 141.1 3.2 3.8e-41 140.5 3.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 BolA PF01722.18 EFX02831.1 - 3.2e-09 36.9 0.0 9.8e-09 35.4 0.0 1.8 1 1 0 1 1 1 1 BolA-like protein Glycos_transf_2 PF00535.26 EFX02832.1 - 1.9e-21 76.6 0.1 2.7e-21 76.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EFX02832.1 - 7.9e-21 74.9 2.1 7.9e-21 74.9 2.1 3.0 2 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EFX02832.1 - 8.4e-19 67.7 0.0 1.4e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EFX02832.1 - 1.3e-15 57.9 0.2 2.2e-15 57.2 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_hydro_12 PF01670.16 EFX02832.1 - 5.8e-12 46.1 5.4 7.1e-11 42.5 3.6 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 12 Cellulose_synt PF03552.14 EFX02832.1 - 3.1e-06 26.0 2.3 0.0033 16.0 1.3 2.2 2 0 0 2 2 2 2 Cellulose synthase Pmp3 PF01679.17 EFX02834.1 - 4.5e-25 87.6 8.5 5e-25 87.4 8.5 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Pectate_lyase PF03211.13 EFX02836.1 - 4e-85 284.5 8.8 4.7e-85 284.3 8.8 1.0 1 0 0 1 1 1 1 Pectate lyase Mpp10 PF04006.12 EFX02837.1 - 8.3e-104 348.2 38.7 1.3e-102 344.3 38.6 2.0 1 1 0 1 1 1 1 Mpp10 protein S-AdoMet_synt_C PF02773.16 EFX02838.1 - 3.6e-65 218.1 0.4 7.4e-65 217.1 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EFX02838.1 - 1.5e-45 154.3 0.0 3e-45 153.4 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EFX02838.1 - 1.6e-42 144.2 0.6 3.5e-42 143.1 0.1 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain DUF2312 PF10073.9 EFX02838.1 - 0.18 11.5 0.4 0.49 10.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) SRP54 PF00448.22 EFX02840.1 - 8.4e-06 25.5 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EFX02840.1 - 0.0004 20.8 1.1 0.0093 16.4 1.1 2.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFX02840.1 - 0.00042 20.3 0.0 0.001 19.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain MeaB PF03308.16 EFX02840.1 - 0.0024 16.9 0.0 0.0041 16.2 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EFX02840.1 - 0.0095 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin KAP_NTPase PF07693.14 EFX02840.1 - 0.017 14.3 0.0 0.023 14.0 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain cobW PF02492.19 EFX02840.1 - 0.02 14.5 0.0 0.042 13.5 0.0 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ArsA_ATPase PF02374.15 EFX02840.1 - 0.022 14.0 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase AAA_30 PF13604.6 EFX02840.1 - 0.022 14.5 0.0 0.65 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EFX02840.1 - 0.025 14.5 0.2 0.04 13.8 0.2 1.3 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 EFX02840.1 - 0.029 14.9 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFX02840.1 - 0.029 14.8 0.0 0.078 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFX02840.1 - 0.036 14.1 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFX02840.1 - 0.065 13.7 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 EFX02840.1 - 0.08 13.2 0.1 0.28 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_31 PF13614.6 EFX02840.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFX02840.1 - 0.13 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EFX02840.1 - 0.14 12.0 0.2 0.35 10.8 0.2 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.22 EFX02840.1 - 0.15 11.2 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Thymidylate_kin PF02223.17 EFX02840.1 - 0.17 11.5 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Thymidylate kinase Inv-AAD PF18785.1 EFX02841.1 - 1.3e-56 189.9 0.0 1.5e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EFX02841.1 - 2.1e-11 43.6 0.0 2.9e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EFX02841.1 - 0.00025 21.0 0.0 0.00029 20.8 0.0 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain L31 PF09784.9 EFX02842.1 - 3.5e-32 110.9 0.5 3.8e-32 110.8 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 ATP-synt_ab PF00006.25 EFX02843.1 - 1.6e-109 364.6 0.0 2.1e-109 364.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EFX02843.1 - 3.7e-46 155.9 0.0 6.5e-46 155.1 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EFX02843.1 - 1.2e-14 54.5 3.6 3e-14 53.3 3.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain UQ_con PF00179.26 EFX02844.1 - 6.5e-51 171.7 0.0 7.3e-51 171.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX02844.1 - 7.4e-05 22.5 0.0 8.5e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFX02844.1 - 0.051 13.9 0.0 0.066 13.5 0.0 1.4 1 1 0 1 1 1 0 RWD domain Adeno_E3_14_5 PF04834.12 EFX02844.1 - 0.11 13.0 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 Early E3 14.5 kDa protein Fungal_trans PF04082.18 EFX02845.1 - 3.8e-15 55.7 0.2 6.5e-15 54.9 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phage_holin_2_2 PF10746.9 EFX02845.1 - 0.028 14.1 0.2 0.078 12.7 0.2 1.7 1 0 0 1 1 1 0 Phage holin T7 family, holin superfamily II Glyco_hydro_125 PF06824.11 EFX02846.1 - 2.3e-167 557.1 0.1 2.8e-165 550.3 0.1 2.0 1 1 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) ACBP PF00887.19 EFX02847.1 - 1.1e-22 80.0 0.9 1.3e-22 79.8 0.9 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Pkinase PF00069.25 EFX02848.1 - 1.8e-43 148.8 0.0 1.5e-41 142.5 0.0 2.8 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02848.1 - 6e-25 88.0 0.0 2.1e-24 86.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Methyltransf_12 PF08242.12 EFX02850.1 - 0.00034 21.3 0.0 0.00062 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX02850.1 - 0.00094 19.1 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02850.1 - 0.001 19.7 0.0 0.0021 18.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02850.1 - 0.0037 18.0 0.0 0.0073 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02850.1 - 0.01 15.7 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain 2OG-FeII_Oxy_3 PF13640.6 EFX02851.1 - 9.6e-07 29.6 0.0 3.1e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RNA_pol_L_2 PF13656.6 EFX02852.1 - 2.5e-31 107.3 0.0 3.5e-31 106.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFX02852.1 - 5e-11 41.9 0.0 7.3e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Peptidase_C48 PF02902.19 EFX02853.1 - 4.1e-33 115.1 0.0 1.8e-32 112.9 0.0 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain AMP-binding PF00501.28 EFX02856.1 - 4.6e-92 308.8 0.0 5.4e-92 308.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX02856.1 - 1.6e-13 51.4 0.1 3.8e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RrnaAD PF00398.20 EFX02857.1 - 3.4e-44 150.9 0.0 4.8e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFX02857.1 - 0.0016 19.1 0.0 0.0062 17.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02857.1 - 0.014 16.0 0.0 0.059 14.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Formyl_trans_N PF00551.19 EFX02858.1 - 1.2e-21 77.2 0.0 2.7e-21 76.1 0.0 1.6 2 0 0 2 2 2 1 Formyl transferase GTP1_OBG PF01018.22 EFX02859.1 - 7e-38 129.6 1.6 3e-28 98.4 4.9 2.3 2 0 0 2 2 2 2 GTP1/OBG Methyltr_RsmB-F PF01189.17 EFX02859.1 - 9e-30 103.8 0.0 1.2e-27 96.8 0.0 3.4 3 1 0 3 3 3 1 16S rRNA methyltransferase RsmB/F MMR_HSR1 PF01926.23 EFX02859.1 - 3e-23 82.1 0.0 1.1e-22 80.2 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX02859.1 - 6.9e-07 28.9 0.0 3.2e-05 23.5 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B FtsJ PF01728.19 EFX02859.1 - 0.013 15.6 0.0 0.029 14.5 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase MeaB PF03308.16 EFX02859.1 - 0.056 12.4 0.2 1.4 7.8 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFX02859.1 - 0.11 13.1 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Arf PF00025.21 EFX02859.1 - 0.17 11.3 0.0 0.93 8.9 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_18 PF13238.6 EFX02859.1 - 0.48 11.0 0.0 0.48 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain A_deaminase PF00962.22 EFX02860.1 - 1.1e-10 41.3 0.0 3e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 EFX02860.1 - 0.0092 16.3 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal MCM PF00493.23 EFX02861.1 - 4.2e-104 346.5 0.1 9.7e-104 345.3 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EFX02861.1 - 3.2e-35 120.7 0.4 6.1e-35 119.8 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFX02861.1 - 2.3e-28 98.4 2.1 5.3e-28 97.3 2.1 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFX02861.1 - 2.8e-16 60.0 0.7 6.3e-16 58.9 0.7 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFX02861.1 - 9.5e-07 28.4 0.0 0.00021 20.7 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFX02861.1 - 2.3e-05 24.4 0.0 5.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFX02861.1 - 0.0006 19.7 0.0 0.002 18.0 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFX02861.1 - 0.052 13.3 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 EFX02861.1 - 0.091 13.2 0.0 0.37 11.2 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) F-box-like PF12937.7 EFX02862.1 - 6.9e-08 32.3 0.8 1.5e-07 31.2 0.8 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFX02862.1 - 0.081 13.4 0.2 11 6.6 0.0 3.9 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) F-box PF00646.33 EFX02862.1 - 0.34 10.8 7.6 2.9 7.9 7.6 2.4 1 1 0 1 1 1 0 F-box domain PfkB PF00294.24 EFX02863.1 - 4.7e-58 196.9 2.6 5.3e-58 196.7 2.6 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EFX02863.1 - 0.0078 15.6 0.1 0.017 14.5 0.1 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase F_bP_aldolase PF01116.20 EFX02863.1 - 0.052 13.0 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II HGTP_anticodon PF03129.20 EFX02864.1 - 1.6e-21 76.2 0.0 5e-21 74.7 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFX02864.1 - 4.2e-08 33.4 0.0 3.7e-07 30.3 0.0 2.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) CLAG PF03805.13 EFX02864.1 - 0.19 9.3 0.1 0.26 8.8 0.1 1.1 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein Sec5 PF15469.6 EFX02865.1 - 2e-35 122.4 0.0 1.1e-34 120.0 0.0 2.1 1 1 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 EFX02865.1 - 0.00021 21.3 0.3 0.0031 17.6 0.0 2.8 2 0 0 2 2 2 1 Vps51/Vps67 T2SSF PF00482.23 EFX02865.1 - 2.8 7.9 6.7 8.4 6.4 0.0 4.2 4 1 1 5 5 5 0 Type II secretion system (T2SS), protein F FlgN PF05130.12 EFX02865.1 - 3.1 8.3 12.0 3 8.4 6.8 3.1 3 0 0 3 3 3 0 FlgN protein Zn_clus PF00172.18 EFX02866.1 - 4.6e-06 26.6 9.4 8.6e-06 25.8 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RHINO PF15319.6 EFX02866.1 - 0.92 9.5 5.8 0.97 9.4 2.8 2.2 2 0 0 2 2 2 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein KCNQ2_u3 PF16642.5 EFX02866.1 - 6.1 7.9 14.5 2.6 9.1 1.2 3.2 3 0 0 3 3 3 0 Unstructured region on Potassium channel subunit alpha KvLQT2 SUIM_assoc PF16619.5 EFX02866.1 - 7.8 6.7 11.9 0.63 10.2 0.4 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 dCMP_cyt_deam_1 PF00383.23 EFX02867.1 - 2e-11 43.7 0.3 9.3e-10 38.3 0.3 2.1 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EFX02867.1 - 4.2e-09 36.7 1.7 6.3e-06 26.4 0.5 3.0 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EFX02867.1 - 0.00028 20.6 1.5 0.034 13.7 0.0 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases PP2C PF00481.21 EFX02868.1 - 2.6e-59 201.0 0.0 2.1e-48 165.2 0.0 3.1 2 1 0 2 2 2 2 Protein phosphatase 2C adh_short PF00106.25 EFX02869.1 - 3.4e-31 108.2 0.1 4.5e-31 107.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02869.1 - 4.7e-24 85.2 0.1 5.7e-24 85.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02869.1 - 4.5e-08 33.2 0.1 5.6e-08 32.9 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX02869.1 - 0.0039 16.7 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFX02869.1 - 0.004 17.1 0.1 0.0076 16.2 0.1 1.5 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFX02869.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Proteasome PF00227.26 EFX02870.1 - 9.8e-49 165.4 0.1 1.3e-48 165.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFX02870.1 - 1.5e-12 46.9 0.1 1.5e-12 46.9 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature ADH_zinc_N PF00107.26 EFX02872.1 - 2.3e-09 37.3 0.0 4.1e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX02872.1 - 0.0039 17.1 0.0 0.0096 15.8 0.0 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFX02872.1 - 0.12 13.4 0.0 0.27 12.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Complex1_LYR PF05347.15 EFX02874.1 - 9.2e-06 25.6 0.1 2.2e-05 24.4 0.1 1.7 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFX02874.1 - 3.2e-05 24.6 0.0 4.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like SH3BGR PF04908.15 EFX02875.1 - 0.00017 21.7 0.0 0.00073 19.7 0.0 1.9 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein SecD-TM1 PF13721.6 EFX02875.1 - 0.13 12.7 0.4 0.47 10.9 0.0 1.9 2 0 0 2 2 2 0 SecD export protein N-terminal TM region MCM PF00493.23 EFX02877.1 - 7.7e-52 175.6 4.6 1.2e-43 148.9 0.0 3.0 2 1 1 3 3 3 2 MCM P-loop domain MCM_OB PF17207.3 EFX02877.1 - 1.4e-39 134.8 0.1 2.6e-39 134.0 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EFX02877.1 - 3.3e-32 111.9 32.4 6.6e-32 110.9 32.4 1.5 1 0 0 1 1 1 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EFX02877.1 - 8.3e-26 90.2 0.7 2.1e-25 88.9 0.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFX02877.1 - 2.6e-15 56.9 0.1 6.3e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 EFX02877.1 - 0.01 15.8 0.0 0.029 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zn_ribbon_2 PF12674.7 EFX02877.1 - 0.08 13.6 0.4 0.26 12.0 0.4 1.9 1 0 0 1 1 1 0 Putative zinc ribbon domain zf-TFIIB PF13453.6 EFX02877.1 - 0.49 9.8 1.7 1.1 8.7 1.7 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger Got1 PF04178.12 EFX02879.1 - 6.4e-15 55.6 12.4 7.8e-15 55.3 12.4 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF3371 PF11851.8 EFX02880.1 - 0.045 14.8 0.0 0.065 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) SAP PF02037.27 EFX02882.1 - 3.7e-12 45.7 0.6 5.8e-12 45.1 0.6 1.3 1 0 0 1 1 1 1 SAP domain SPC22 PF04573.12 EFX02883.1 - 1.6e-38 131.8 0.2 1.4e-37 128.8 0.2 1.9 1 1 0 1 1 1 1 Signal peptidase subunit COA2 PF17051.5 EFX02884.1 - 0.0012 18.8 0.3 0.0018 18.3 0.3 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Frag1 PF10277.9 EFX02885.1 - 4.9e-11 42.6 8.9 8.2e-10 38.6 0.8 4.2 2 2 1 3 3 3 2 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 EFX02885.1 - 0.05 13.1 0.0 0.099 12.1 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Alpha-amylase PF00128.24 EFX02886.1 - 4e-116 388.2 0.0 5.7e-116 387.8 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_114 PF03537.13 EFX02886.1 - 0.024 14.0 2.2 0.18 11.1 0.3 2.4 2 0 0 2 2 2 0 Glycoside-hydrolase family GH114 hDGE_amylase PF14701.6 EFX02886.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Methyltransf_2 PF00891.18 EFX02887.1 - 5.2e-12 45.5 0.0 1.2e-08 34.5 0.0 2.3 1 1 1 2 2 2 2 O-methyltransferase domain DUF1152 PF06626.12 EFX02887.1 - 0.13 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) DIOX_N PF14226.6 EFX02888.1 - 2.7e-21 76.5 0.0 4.5e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX02888.1 - 7.7e-14 52.0 0.0 1.8e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MJ1316 PF04457.12 EFX02889.1 - 1.6e-19 70.4 1.9 4.1e-19 69.1 1.9 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain PAP_central PF04928.17 EFX02889.1 - 8.1e-12 44.6 0.0 2.1e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Poly(A) polymerase central domain RNA_pol_Rbc25 PF08292.12 EFX02889.1 - 0.11 12.7 1.3 0.22 11.8 1.3 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 SHR3_chaperone PF08229.11 EFX02889.1 - 0.19 10.7 3.7 0.34 9.9 3.7 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 E7 PF00527.18 EFX02889.1 - 1.6 9.0 3.2 4.2 7.6 3.2 1.6 1 0 0 1 1 1 0 E7 protein, Early protein AA_permease PF00324.21 EFX02890.1 - 3e-122 408.6 40.0 3e-122 408.6 40.0 2.4 3 0 0 3 3 3 1 Amino acid permease Voltage_CLC PF00654.20 EFX02890.1 - 8e-85 285.2 30.6 8e-85 285.2 30.6 3.7 4 1 0 4 4 4 1 Voltage gated chloride channel AA_permease_2 PF13520.6 EFX02890.1 - 5.1e-29 101.4 43.0 5.1e-29 101.4 43.0 2.9 2 1 0 2 2 2 1 Amino acid permease CBS PF00571.28 EFX02890.1 - 1.7e-10 41.1 0.0 0.00073 19.9 0.0 2.8 2 0 0 2 2 2 2 CBS domain ASCH PF04266.14 EFX02890.1 - 0.027 15.0 0.0 0.063 13.9 0.0 1.5 1 0 0 1 1 1 0 ASCH domain LPAM_1 PF08139.12 EFX02890.1 - 7.9 7.2 6.3 12 6.6 0.1 3.5 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site Zn_clus PF00172.18 EFX02891.1 - 4.4e-07 29.9 11.5 7.8e-07 29.1 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFX02891.1 - 8.2e-05 21.6 0.1 0.00012 21.0 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain SIS PF01380.22 EFX02892.1 - 1.5e-15 57.2 0.1 3.8e-14 52.7 0.0 2.4 2 0 0 2 2 2 1 SIS domain SAE2 PF08573.10 EFX02893.1 - 3.9e-36 124.5 0.3 3.9e-36 124.5 0.3 2.8 2 0 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus RhoGEF PF00621.20 EFX02894.1 - 3.4e-07 30.7 0.6 1.9e-06 28.2 0.6 2.0 1 1 0 1 1 1 1 RhoGEF domain SUV3_C PF12513.8 EFX02895.1 - 2.8e-19 68.8 0.6 5.9e-19 67.7 0.6 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 EFX02895.1 - 1.8e-14 53.3 0.4 4.9e-14 51.9 0.4 1.8 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 EFX02895.1 - 3.9e-09 36.8 0.0 8.2e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TK PF00265.18 EFX02895.1 - 0.022 14.6 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Thymidine kinase E1-E2_ATPase PF00122.20 EFX02896.1 - 3.2e-47 160.4 2.1 3.2e-47 160.4 2.1 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFX02896.1 - 2.1e-46 158.0 5.8 4.9e-46 156.7 5.8 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFX02896.1 - 1.2e-23 84.5 1.8 7e-23 82.0 1.8 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFX02896.1 - 4.1e-20 71.7 0.0 7.2e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFX02896.1 - 1.2e-17 63.3 0.0 3.6e-17 61.8 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFX02896.1 - 2.6e-07 30.7 0.8 4.2e-06 26.7 0.5 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFX02896.1 - 4.3e-06 27.3 0.0 1.7e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Tyr-DNA_phospho PF06087.12 EFX02897.1 - 7.3e-156 519.3 0.0 8.4e-156 519.1 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EFX02897.1 - 0.016 15.1 0.0 1.5 8.7 0.0 2.3 2 0 0 2 2 2 0 PLD-like domain LRR_9 PF14580.6 EFX02898.1 - 1.9e-53 180.5 0.0 3.2e-53 179.8 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EFX02898.1 - 1.3e-08 34.5 2.8 5.3e-08 32.5 1.9 2.4 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EFX02898.1 - 8.6e-08 32.4 0.6 8.6e-08 32.4 0.6 3.4 3 1 0 4 4 4 1 Leucine Rich repeats (2 copies) DUF4349 PF14257.6 EFX02898.1 - 0.0079 15.7 3.6 0.014 14.9 3.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) LRR_6 PF13516.6 EFX02898.1 - 0.04 14.0 2.2 39 4.7 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich repeat HTH_38 PF13936.6 EFX02898.1 - 0.16 11.7 1.7 0.37 10.6 1.7 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MoCF_biosynth PF00994.24 EFX02899.1 - 1.1e-20 73.7 0.0 2.8e-20 72.5 0.0 1.6 1 1 0 1 1 1 1 Probable molybdopterin binding domain Tim54 PF11711.8 EFX02900.1 - 0.14 11.0 0.2 0.22 10.3 0.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ses_B PF17046.5 EFX02901.1 - 0.17 11.8 1.2 0.34 10.9 1.2 1.4 1 0 0 1 1 1 0 SesB domain on fungal death-pathway protein GCP_C_terminal PF04130.13 EFX02902.1 - 4.1e-90 302.4 0.0 2.8e-89 299.7 0.0 2.2 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFX02902.1 - 1.2e-82 277.9 0.0 1.9e-82 277.4 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal CDC45 PF02724.14 EFX02903.1 - 0.035 12.4 5.9 0.041 12.2 5.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Pes-10 PF07149.11 EFX02903.1 - 4.6 6.2 5.4 5.8 5.9 5.4 1.1 1 0 0 1 1 1 0 Pes-10 Cadherin-like PF12733.7 EFX02904.1 - 6.4 7.4 6.3 16 6.1 0.1 3.0 3 0 0 3 3 3 0 Cadherin-like beta sandwich domain Ribosomal_L37e PF01907.19 EFX02905.1 - 9.7e-28 96.1 12.1 1.6e-27 95.4 12.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e zf-C4pol PF14260.6 EFX02905.1 - 0.018 15.5 1.6 0.024 15.1 0.9 1.6 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta HypA PF01155.19 EFX02905.1 - 0.048 13.7 1.0 0.066 13.2 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 EFX02905.1 - 0.072 12.8 2.1 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-RING_10 PF16685.5 EFX02905.1 - 0.074 13.2 3.0 0.095 12.9 3.0 1.2 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_2 PF13923.6 EFX02905.1 - 0.88 9.5 5.5 1.4 8.8 5.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cofilin_ADF PF00241.20 EFX02906.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Cofilin_ADF PF00241.20 EFX02907.1 - 6e-18 64.8 0.0 7.5e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ABC_tran PF00005.27 EFX02908.1 - 6.2e-53 179.0 0.0 2.3e-29 102.7 0.0 3.8 3 1 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EFX02908.1 - 1.7e-38 132.8 25.3 7.2e-27 94.7 12.9 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFX02908.1 - 3.6e-08 33.1 0.6 0.053 13.0 0.1 4.0 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFX02908.1 - 5.6e-06 26.0 0.1 0.018 14.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EFX02908.1 - 2.3e-05 24.6 0.9 0.033 14.3 0.0 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_16 PF13191.6 EFX02908.1 - 3.3e-05 24.3 0.0 0.67 10.3 0.0 3.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EFX02908.1 - 3.5e-05 24.4 0.1 0.0072 16.8 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFX02908.1 - 0.00018 21.1 0.1 0.17 11.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EFX02908.1 - 0.0004 20.7 0.0 1.9 8.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 EFX02908.1 - 0.0005 19.4 0.1 0.15 11.3 0.0 2.8 3 0 0 3 3 3 1 Zeta toxin T2SSE PF00437.20 EFX02908.1 - 0.0008 18.6 0.0 0.035 13.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EFX02908.1 - 0.0017 18.4 0.1 0.78 9.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EFX02908.1 - 0.0045 16.8 0.5 2.4 7.9 0.2 3.7 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFX02908.1 - 0.0086 16.0 0.1 2.6 7.9 0.1 2.7 3 0 0 3 3 2 1 RsgA GTPase NB-ARC PF00931.22 EFX02908.1 - 0.021 14.0 0.1 3.3 6.8 0.0 3.1 3 0 0 3 3 3 0 NB-ARC domain NACHT PF05729.12 EFX02908.1 - 0.023 14.6 0.7 2.3 8.1 0.2 2.4 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EFX02908.1 - 0.048 13.4 0.0 12 5.5 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain ATPase PF06745.13 EFX02908.1 - 0.14 11.5 0.2 2.8 7.2 0.0 2.2 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 EFX02908.1 - 0.18 11.0 0.3 0.88 8.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF1600 PF07667.11 EFX02908.1 - 1.4 9.1 5.4 0.52 10.5 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1600) EXOSC1 PF10447.9 EFX02909.1 - 1e-19 71.2 3.5 1.1e-14 55.0 0.2 2.3 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EFX02909.1 - 6.6e-12 45.0 0.2 1.5e-11 43.9 0.2 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region WD40 PF00400.32 EFX02910.1 - 5.5e-14 52.3 4.1 0.003 18.4 0.0 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02910.1 - 0.0025 18.1 0.0 4.9 7.5 0.0 4.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 EFX02910.1 - 0.17 11.2 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region Translin PF01997.16 EFX02911.1 - 2.5e-39 135.4 0.0 2.9e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Translin family SusD_RagB PF07980.11 EFX02911.1 - 0.19 11.3 0.2 0.32 10.5 0.2 1.3 1 0 0 1 1 1 0 SusD family NCA2 PF08637.10 EFX02912.1 - 2.1e-108 361.9 0.0 4.1e-108 360.9 0.0 1.5 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Sec10 PF07393.11 EFX02914.1 - 9.5e-197 655.7 8.2 1.5e-134 450.1 6.6 2.1 1 1 1 2 2 2 2 Exocyst complex component Sec10 IBR PF01485.21 EFX02916.1 - 6.6e-05 23.1 4.3 6.6e-05 23.1 4.3 4.6 5 0 0 5 5 5 2 IBR domain, a half RING-finger domain OTT_1508_deam PF14441.6 EFX02917.1 - 2e-19 69.4 0.5 5.3e-19 68.0 0.5 1.8 1 0 0 1 1 1 1 OTT_1508-like deaminase DUF1770 PF08589.10 EFX02918.1 - 9.6e-31 106.7 0.0 1.3e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) MRC1 PF09444.10 EFX02919.1 - 3.5e-43 147.6 19.2 3.5e-43 147.6 19.2 8.5 7 2 2 9 9 9 1 MRC1-like domain GATA PF00320.27 EFX02920.1 - 2.2e-28 97.6 15.1 8e-15 54.2 3.8 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EFX02920.1 - 0.00014 21.3 3.6 0.25 10.9 0.1 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Auto_anti-p27 PF06677.12 EFX02920.1 - 0.00063 19.8 6.1 0.094 12.9 0.2 2.7 3 0 0 3 3 3 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) OrfB_Zn_ribbon PF07282.11 EFX02920.1 - 0.009 15.9 3.9 0.17 11.8 0.3 2.7 2 0 0 2 2 2 1 Putative transposase DNA-binding domain ArfGap PF01412.18 EFX02920.1 - 0.016 15.3 3.4 1.2 9.3 0.2 2.6 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf zf-RRN7 PF11781.8 EFX02920.1 - 0.047 13.4 0.3 0.047 13.4 0.3 2.8 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF2318 PF10080.9 EFX02920.1 - 0.084 13.0 1.1 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) eIF-5_eIF-2B PF01873.17 EFX02920.1 - 0.11 12.4 3.5 4.3 7.2 0.3 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Zn-ribbon_8 PF09723.10 EFX02920.1 - 0.39 10.9 7.4 0.98 9.6 0.1 2.9 3 0 0 3 3 3 0 Zinc ribbon domain HIPIP PF01355.17 EFX02920.1 - 2.1 8.7 5.2 18 5.8 0.0 3.6 4 0 0 4 4 4 0 High potential iron-sulfur protein Tnp_zf-ribbon_2 PF13842.6 EFX02920.1 - 4.1 8.3 8.7 3.8 8.4 1.6 2.8 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DZR PF12773.7 EFX02920.1 - 7.2 6.7 13.1 8.9 6.4 0.5 3.3 2 1 1 3 3 3 0 Double zinc ribbon adh_short PF00106.25 EFX02921.1 - 5.6e-48 163.0 0.2 1.1e-47 162.1 0.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02921.1 - 7.4e-32 110.8 0.1 1.1e-31 110.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02921.1 - 3.8e-11 43.2 0.0 5.5e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 KR domain TAP42 PF04177.12 EFX02922.1 - 4.7e-94 315.1 0.0 6e-94 314.8 0.0 1.1 1 0 0 1 1 1 1 TAP42-like family Cwf_Cwc_15 PF04889.12 EFX02922.1 - 0.11 12.2 6.2 0.3 10.8 6.2 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein eIF3_subunit PF08597.10 EFX02922.1 - 0.71 9.7 7.5 1.7 8.5 7.1 1.7 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit Aquarius_N PF16399.5 EFX02923.1 - 0 1079.0 0.0 0 1078.7 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EFX02923.1 - 4.4e-26 91.7 0.0 7.2e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFX02923.1 - 1e-19 71.4 0.0 4.6e-19 69.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX02923.1 - 2e-07 30.9 0.0 0.00033 20.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 EFX02923.1 - 1e-05 25.6 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFX02923.1 - 1.9e-05 25.1 0.0 3.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX02923.1 - 0.003 18.0 2.9 0.0076 16.6 0.0 3.1 3 1 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EFX02923.1 - 0.0034 17.8 0.0 0.0083 16.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EFX02923.1 - 0.021 14.2 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EFX02923.1 - 0.036 14.3 0.1 0.19 12.0 0.1 2.2 1 1 1 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 EFX02923.1 - 0.037 13.9 0.1 0.1 12.4 0.1 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain SMC_N PF02463.19 EFX02923.1 - 0.043 13.3 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Parvo_NS1 PF01057.17 EFX02923.1 - 0.043 12.9 0.0 0.087 11.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.18 EFX02923.1 - 0.044 13.5 0.0 2 8.1 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EFX02923.1 - 0.056 12.7 1.0 0.09 12.0 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RecA PF00154.21 EFX02923.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein DEAD PF00270.29 EFX02923.1 - 0.17 11.7 0.0 0.57 9.9 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase GRP PF07172.11 EFX02923.1 - 3 8.6 16.0 35 5.2 15.1 2.3 2 0 0 2 2 2 0 Glycine rich protein family WD40 PF00400.32 EFX02925.1 - 5.8e-06 27.0 0.3 0.9 10.5 0.0 5.6 7 0 0 7 7 7 2 WD domain, G-beta repeat 4HBT PF03061.22 EFX02926.1 - 4.9e-08 33.2 0.0 6.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 EFX02926.1 - 2e-06 28.3 0.2 2.7e-06 27.9 0.2 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 EFX02926.1 - 0.00011 21.6 1.7 0.00023 20.6 1.8 1.3 1 1 0 1 1 1 1 Acyl-ACP thioesterase Kinesin PF00225.23 EFX02927.1 - 1e-112 376.4 0.2 2.2e-112 375.3 0.2 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFX02927.1 - 3.5e-26 91.9 0.0 1.2e-25 90.2 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding DUF2048 PF09752.9 EFX02927.1 - 0.062 12.4 0.3 0.13 11.3 0.3 1.5 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Pkinase PF00069.25 EFX02928.1 - 5e-68 229.3 0.0 9.8e-68 228.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX02928.1 - 8.3e-48 162.9 0.0 1.5e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EFX02928.1 - 8.6e-27 93.4 0.0 1.8e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 EFX02928.1 - 4.4e-17 61.9 0.3 1.5e-16 60.2 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFX02928.1 - 8.3e-16 58.2 0.1 1.7e-15 57.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EFX02928.1 - 5.4e-13 49.4 0.4 1.3e-12 48.2 0.0 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.6 EFX02928.1 - 5.9e-08 32.4 0.0 0.00018 21.0 0.0 2.5 3 0 0 3 3 3 2 Kinase-like SAM_PNT PF02198.16 EFX02928.1 - 0.0059 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_4 PF18017.1 EFX02928.1 - 0.013 15.4 0.1 0.032 14.2 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EFX02928.1 - 0.017 13.9 0.0 0.041 12.7 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase FAD_binding_3 PF01494.19 EFX02930.1 - 6.8e-17 61.7 1.8 2.4e-11 43.5 1.3 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EFX02930.1 - 0.0012 19.1 0.5 0.099 12.9 0.0 2.9 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Latarcin PF10279.9 EFX02931.1 - 0.15 12.5 3.2 3.5 8.1 0.1 2.4 1 1 1 2 2 2 0 Latarcin precursor TPR_19 PF14559.6 EFX02933.1 - 0.08 13.5 0.3 0.08 13.5 0.3 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TFIIA_gamma_N PF02268.16 EFX02934.1 - 2.9e-25 88.0 0.3 4e-25 87.6 0.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 EFX02934.1 - 1.9e-22 79.1 0.2 3e-22 78.5 0.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit Methyltransf_11 PF08241.12 EFX02935.1 - 1.2e-09 38.7 0.0 2.3e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX02935.1 - 8.9e-09 35.4 0.0 1.2e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02935.1 - 3.8e-07 30.7 0.0 1.1e-06 29.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02935.1 - 0.0021 18.8 0.0 0.0095 16.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02935.1 - 0.04 13.7 0.0 0.088 12.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EFX02935.1 - 0.043 13.7 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Ubie_methyltran PF01209.18 EFX02935.1 - 0.087 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.12 EFX02935.1 - 0.18 11.3 0.1 0.36 10.3 0.1 1.5 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Ribosomal_L32e PF01655.18 EFX02936.1 - 2.9e-49 166.0 0.9 2.9e-49 166.0 0.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L32 cNMP_binding PF00027.29 EFX02937.1 - 2.8e-29 101.0 0.1 7e-17 61.3 0.1 5.4 5 0 0 5 5 5 3 Cyclic nucleotide-binding domain Patatin PF01734.22 EFX02937.1 - 5.5e-14 52.8 7.4 1.9e-12 47.8 7.4 2.6 1 1 0 1 1 1 1 Patatin-like phospholipase POP1 PF06978.11 EFX02938.1 - 1.7e-35 122.9 17.3 5.6e-22 78.7 5.6 2.7 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EFX02938.1 - 2.4e-27 95.1 0.1 8.7e-27 93.3 0.1 2.0 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.11 EFX02938.1 - 0.026 14.4 0.0 0.094 12.7 0.0 1.9 2 0 0 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain DUF4048 PF13257.6 EFX02939.1 - 1.2e-09 38.4 18.6 1.2e-09 38.4 18.6 3.8 3 1 0 3 3 3 1 Domain of unknown function (DUF4048) AAA_2 PF07724.14 EFX02940.1 - 6.1e-12 46.0 0.0 1.5e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFX02940.1 - 2.8e-10 40.4 0.0 5.9e-09 36.0 0.0 2.6 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EFX02940.1 - 7.9e-06 26.3 0.0 1.8e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 EFX02940.1 - 6.6e-05 23.0 0.0 0.00015 21.9 0.0 1.5 1 0 0 1 1 1 1 Torsin ClpB_D2-small PF10431.9 EFX02940.1 - 9.8e-05 22.3 0.1 0.00024 21.1 0.1 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 EFX02940.1 - 0.0014 19.0 0.4 0.025 14.9 0.2 2.9 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 EFX02940.1 - 0.0033 16.8 0.1 2.7 7.3 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_6 PF12774.7 EFX02940.1 - 0.02 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 EFX02940.1 - 0.025 14.3 0.0 0.056 13.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EFX02940.1 - 0.13 12.5 0.1 0.96 9.7 0.1 2.5 1 1 0 1 1 1 0 AAA domain Scytalone_dh PF02982.14 EFX02941.1 - 1.3e-56 190.8 1.1 1.5e-56 190.6 1.1 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EFX02941.1 - 1.2e-09 38.3 2.2 1.6e-09 38.0 2.2 1.1 1 0 0 1 1 1 1 SnoaL-like domain GATA PF00320.27 EFX02942.1 - 2.1e-16 59.2 2.3 4e-16 58.3 2.3 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EFX02942.1 - 3.5e-11 42.7 0.2 6.5e-11 41.9 0.2 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) p450 PF00067.22 EFX02943.1 - 1.7e-28 99.6 0.0 1.2e-16 60.6 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 Methyltransf_23 PF13489.6 EFX02944.1 - 1.9e-13 50.6 0.0 4.4e-13 49.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02944.1 - 1.6e-06 28.7 0.1 1.3e-05 25.8 0.1 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02944.1 - 0.00032 21.3 0.0 0.00074 20.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02944.1 - 0.0045 17.7 0.1 0.082 13.7 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02944.1 - 0.014 15.2 0.0 0.35 10.6 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EFX02944.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EFX02944.1 - 0.18 11.1 0.1 0.43 9.9 0.1 1.7 1 1 0 1 1 1 0 O-methyltransferase domain Zip PF02535.22 EFX02945.1 - 3.9e-55 187.4 10.4 2.7e-44 151.8 7.0 2.3 1 1 1 2 2 2 2 ZIP Zinc transporter Phage_holin_5_1 PF06946.11 EFX02945.1 - 1.5 9.3 6.9 3.8 8.0 3.1 3.0 3 0 0 3 3 3 0 Bacteriophage A118-like holin, Hol118 DUF4690 PF15756.5 EFX02946.1 - 0.04 14.5 1.2 0.04 14.5 1.2 1.9 2 1 0 2 2 2 0 Small Novel Rich in Cartilage VSP PF03302.13 EFX02946.1 - 0.79 8.5 9.4 0.025 13.5 3.3 1.5 2 0 0 2 2 2 0 Giardia variant-specific surface protein CBFD_NFYB_HMF PF00808.23 EFX02947.1 - 1.7e-06 28.2 0.0 0.016 15.4 0.0 2.4 2 0 0 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone FGGY_C PF02782.16 EFX02948.1 - 8e-70 234.6 1.7 1.5e-69 233.7 1.7 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFX02948.1 - 3.4e-58 197.1 0.0 4.6e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Homeobox_KN PF05920.11 EFX02949.1 - 2.2e-21 75.5 0.5 3.9e-21 74.6 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFX02949.1 - 1.1e-08 34.8 1.5 2e-08 33.9 1.5 1.4 1 0 0 1 1 1 1 Homeodomain Nup54 PF13874.6 EFX02950.1 - 0.00014 22.0 4.7 0.00072 19.7 0.4 2.4 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup88 PF10168.9 EFX02950.1 - 0.0053 14.6 0.2 2 6.2 0.1 2.2 2 0 0 2 2 2 2 Nuclear pore component ATP-synt_D PF01813.17 EFX02950.1 - 0.15 11.8 0.2 1.5 8.6 0.2 2.2 2 0 0 2 2 2 0 ATP synthase subunit D MFS_1 PF07690.16 EFX02951.1 - 4.9e-38 131.0 48.2 7.3e-38 130.4 48.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX02951.1 - 4.7e-11 41.8 21.4 8.3e-11 41.0 21.4 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PALP PF00291.25 EFX02952.1 - 2.1e-59 201.3 0.1 2.6e-59 201.0 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EFX02952.1 - 1.5e-11 44.6 0.2 9.3e-08 32.4 0.0 3.4 2 1 0 3 3 3 2 CBS domain PRMT5 PF05185.16 EFX02952.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase p450 PF00067.22 EFX02953.1 - 3.7e-52 177.6 0.0 7.6e-52 176.6 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Solute_trans_a PF03619.16 EFX02955.1 - 4.7e-77 259.1 1.3 3.4e-75 253.0 0.1 2.0 1 1 1 2 2 2 2 Organic solute transporter Ostalpha Dpy-30 PF05186.13 EFX02956.1 - 0.00038 20.1 0.0 0.00056 19.6 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif PseudoU_synth_2 PF00849.22 EFX02957.1 - 4e-33 114.8 0.0 6.9e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase adh_short_C2 PF13561.6 EFX02958.1 - 1.6e-55 188.2 0.1 2.5e-55 187.6 0.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX02958.1 - 2.5e-51 173.9 0.1 3.5e-51 173.4 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX02958.1 - 9.6e-15 54.9 0.2 1.3e-14 54.5 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX02958.1 - 0.0042 16.6 0.0 0.0067 15.9 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ctr PF04145.15 EFX02959.1 - 1.9e-32 112.9 2.0 2.2e-32 112.7 2.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family FAM176 PF14851.6 EFX02959.1 - 0.05 13.3 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 FAM176 family Arylesterase PF01731.20 EFX02960.1 - 1.6e-05 25.0 0.0 3.5e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Arylesterase MMR_HSR1_C PF08438.10 EFX02961.1 - 9.7e-34 116.3 0.0 1.6e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EFX02961.1 - 4.2e-15 55.8 0.0 3.3e-14 52.9 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX02961.1 - 9.8e-06 25.2 0.0 0.0004 19.9 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFX02961.1 - 0.00077 19.4 0.3 0.61 10.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EFX02961.1 - 0.022 14.8 2.5 0.022 14.8 0.4 2.0 3 0 0 3 3 3 0 Dynamin family Ploopntkinase3 PF18751.1 EFX02961.1 - 0.038 13.9 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 GTP_EFTU PF00009.27 EFX02961.1 - 0.065 12.8 0.2 1.5 8.3 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EFX02961.1 - 0.18 11.9 0.1 0.36 10.9 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Arrestin_C PF02752.22 EFX02962.1 - 4e-19 69.4 0.0 1.7e-18 67.4 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFX02962.1 - 3.1e-11 43.5 0.0 6.5e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EFX02962.1 - 0.006 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like LPD28 PF18843.1 EFX02963.1 - 0.0071 15.9 0.0 4.3 7.0 0.0 2.4 2 1 0 2 2 2 2 Large polyvalent protein associated domain 28 zf-AD PF07776.15 EFX02963.1 - 0.051 13.8 1.3 0.051 13.8 1.3 2.1 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Ribonuclease_3 PF00636.26 EFX02963.1 - 0.16 12.6 0.1 0.27 11.9 0.1 1.3 1 0 0 1 1 1 0 Ribonuclease III domain Fe-ADH PF00465.19 EFX02964.1 - 0.14 10.9 1.0 0.2 10.5 0.1 1.6 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase CMAS PF02353.20 EFX02966.1 - 1.3e-61 208.3 0.0 1.7e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFX02966.1 - 5.2e-11 42.7 0.0 9e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX02966.1 - 4.4e-10 40.1 0.0 8.4e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX02966.1 - 9e-09 35.9 0.0 1.8e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX02966.1 - 0.00072 20.2 0.0 0.0019 18.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX02966.1 - 0.0046 16.8 0.0 0.021 14.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFX02966.1 - 0.026 14.3 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 EFX02966.1 - 0.084 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 EFX02966.1 - 0.18 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain WD40 PF00400.32 EFX02967.1 - 3.1e-38 129.1 28.2 4.3e-08 33.7 0.2 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 EFX02967.1 - 2.9e-12 46.3 0.9 2.9e-12 46.3 0.9 2.2 3 0 0 3 3 3 1 F-box-like ANAPC4_WD40 PF12894.7 EFX02967.1 - 4.3e-08 33.3 2.7 0.19 12.1 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX02967.1 - 3.6e-07 29.2 7.7 0.2 10.3 0.1 5.5 2 1 3 6 6 6 4 Nucleoporin Nup120/160 F-box PF00646.33 EFX02967.1 - 7.9e-06 25.6 2.5 1.8e-05 24.5 2.5 1.7 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 EFX02967.1 - 0.0056 16.0 0.0 2.4 7.4 0.0 2.8 1 1 3 4 4 4 3 WD40-like domain PQQ_2 PF13360.6 EFX02967.1 - 0.012 15.2 7.2 0.38 10.3 0.4 3.5 2 2 2 4 4 4 0 PQQ-like domain PALB2_WD40 PF16756.5 EFX02967.1 - 0.013 14.4 3.4 10 4.9 0.0 3.7 2 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain F-box_5 PF18511.1 EFX02967.1 - 2.8 7.6 4.8 0.34 10.5 0.1 1.9 2 0 0 2 2 2 0 F-box ATG16 PF08614.11 EFX02969.1 - 6.4e-05 23.3 29.6 0.003 17.8 14.8 2.1 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) ZapB PF06005.12 EFX02969.1 - 0.0039 17.6 4.1 0.0039 17.6 4.1 4.4 2 1 2 4 4 4 1 Cell division protein ZapB GAS PF13851.6 EFX02969.1 - 0.0047 16.3 2.7 0.0047 16.3 2.7 3.6 2 2 1 3 3 3 1 Growth-arrest specific micro-tubule binding YscO PF07321.12 EFX02969.1 - 0.02 14.8 9.9 0.02 14.8 9.9 3.1 2 2 0 2 2 2 0 Type III secretion protein YscO TIR-like PF10137.9 EFX02969.1 - 0.026 14.5 0.4 0.48 10.4 0.3 2.4 2 1 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Spc7 PF08317.11 EFX02969.1 - 0.027 13.3 26.5 0.25 10.2 6.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein MT PF12777.7 EFX02969.1 - 0.12 11.3 6.1 0.57 9.1 0.3 2.2 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor CENP-F_leu_zip PF10473.9 EFX02969.1 - 0.13 12.3 25.7 0.7 9.9 7.4 2.9 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 EFX02969.1 - 0.91 9.3 28.4 0.21 11.3 7.4 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family NRBF2 PF08961.10 EFX02969.1 - 1.1 8.8 16.5 0.033 13.8 8.7 2.1 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator AKNA PF12443.8 EFX02969.1 - 2.7 8.7 10.9 0.066 13.9 3.3 2.3 2 0 0 2 2 2 0 AT-hook-containing transcription factor KASH_CCD PF14662.6 EFX02969.1 - 2.7 7.8 29.1 7.4 6.3 0.9 3.3 2 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.12 EFX02969.1 - 3.8 8.0 26.7 5.4 7.5 5.7 3.3 2 1 1 3 3 3 0 Centromere protein H (CENP-H) TLE_N PF03920.15 EFX02969.1 - 4.8 7.3 12.8 1.4 9.0 1.0 3.1 2 1 1 3 3 3 0 Groucho/TLE N-terminal Q-rich domain AAA_13 PF13166.6 EFX02969.1 - 7.2 5.1 18.1 8.9 4.8 2.7 2.1 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.12 EFX02969.1 - 8 6.5 13.7 11 6.1 6.9 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) Actin PF00022.19 EFX02970.1 - 3.9e-54 183.8 0.0 4.3e-52 177.1 0.0 2.2 1 1 0 1 1 1 1 Actin DUF3037 PF11236.8 EFX02970.1 - 3.3 8.1 7.6 0.13 12.7 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) MFS_1 PF07690.16 EFX02971.1 - 6.3e-32 110.9 43.4 9.8e-32 110.2 43.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily CPSase_sm_chain PF00988.22 EFX02972.1 - 7.6e-47 158.3 0.0 1.5e-46 157.4 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EFX02972.1 - 9e-47 159.3 0.0 1.2e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFX02972.1 - 8.2e-06 25.7 0.1 0.00039 20.2 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 Abhydrolase_1 PF00561.20 EFX02973.1 - 3.8e-20 72.6 0.0 1.7e-19 70.5 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX02973.1 - 3.6e-15 55.9 0.0 1.1e-14 54.3 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFX02973.1 - 8.9e-10 39.5 23.3 1.1e-09 39.2 16.8 3.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.11 EFX02973.1 - 6.9e-05 22.3 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 EFX02973.1 - 0.0002 21.1 0.0 0.00064 19.5 0.0 1.9 2 0 0 2 2 2 1 Putative esterase Abhydrolase_2 PF02230.16 EFX02973.1 - 0.021 14.7 0.0 4.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 EFX02973.1 - 0.023 14.8 0.4 0.1 12.7 0.4 2.0 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.13 EFX02973.1 - 0.056 13.3 0.8 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold OTCace_N PF02729.21 EFX02973.1 - 0.11 12.5 0.0 3.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain MR_MLE_C PF13378.6 EFX02974.1 - 1.5e-41 142.4 0.0 2e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFX02974.1 - 1.3e-10 41.5 0.0 2.1e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain adh_short PF00106.25 EFX02975.1 - 1.2e-83 279.4 13.7 4.8e-43 146.9 4.6 2.5 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02975.1 - 2.7e-67 226.8 15.1 7.4e-35 120.6 3.1 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EFX02975.1 - 2.6e-30 104.5 0.0 5.7e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EFX02975.1 - 4.9e-27 95.0 6.4 6.6e-14 52.2 1.3 2.3 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EFX02975.1 - 0.004 16.6 5.1 0.057 12.9 0.3 3.0 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family DUF3328 PF11807.8 EFX02976.1 - 2.2e-19 70.1 3.2 5.1e-19 68.9 0.7 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF3328) UQ_con PF00179.26 EFX02979.1 - 1.7e-23 82.8 0.1 2.9e-23 82.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX02979.1 - 1.1e-05 25.1 0.0 2e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFX02979.1 - 0.028 14.3 0.1 0.052 13.4 0.1 1.4 1 0 0 1 1 1 0 UEV domain adh_short PF00106.25 EFX02980.1 - 2.2e-19 69.7 0.0 3.6e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX02980.1 - 2.5e-12 46.9 0.0 3.2e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX02980.1 - 1.9e-06 27.9 0.0 3.1e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Pyr_redox_2 PF07992.14 EFX02981.1 - 5.4e-49 167.0 3.4 8.5e-49 166.4 3.4 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EFX02981.1 - 2.6e-15 56.1 0.0 6.5e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EFX02981.1 - 1.3e-11 44.9 3.3 4e-10 40.1 0.5 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EFX02981.1 - 3.2e-06 27.6 0.2 1.6e-05 25.4 0.0 2.3 2 0 0 2 2 2 1 Reductase C-terminal Rieske_2 PF13806.6 EFX02981.1 - 5.9e-06 26.2 0.0 6.3e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Pyr_redox_3 PF13738.6 EFX02981.1 - 4e-05 23.0 0.1 0.12 11.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX02981.1 - 0.00073 19.6 5.1 0.39 10.7 0.1 3.3 3 0 0 3 3 3 2 FAD-NAD(P)-binding DUF1188 PF06690.11 EFX02981.1 - 0.0051 16.4 0.1 0.0094 15.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) K_oxygenase PF13434.6 EFX02981.1 - 0.012 14.8 0.3 2.4 7.2 0.0 2.5 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 EFX02981.1 - 0.55 10.7 2.6 4 7.9 0.1 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding GTP_EFTU PF00009.27 EFX02982.1 - 3.1e-66 222.6 0.3 3.1e-66 222.6 0.3 1.6 2 0 0 2 2 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFX02982.1 - 6.1e-31 106.7 0.0 1.8e-30 105.2 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EFX02982.1 - 9.8e-22 76.8 0.0 2.3e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFX02982.1 - 2.4e-12 47.1 0.1 1.6e-11 44.4 0.1 2.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFX02982.1 - 2.1e-11 43.7 0.0 5.8e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II RRM_1 PF00076.22 EFX02982.1 - 2.3e-05 24.1 0.4 0.00013 21.7 0.1 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFX02982.1 - 7.6e-05 22.6 0.0 0.00018 21.4 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif MMR_HSR1 PF01926.23 EFX02982.1 - 0.002 18.2 0.3 0.0045 17.1 0.3 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase PWI PF01480.17 EFX02982.1 - 0.0076 16.5 0.0 0.046 14.0 0.0 2.2 1 1 0 1 1 1 1 PWI domain DUF4523 PF15023.6 EFX02982.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) zf-CCCH PF00642.24 EFX02982.1 - 0.015 15.2 6.6 0.027 14.4 6.6 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.11 EFX02982.1 - 0.062 13.4 2.6 0.97 9.5 0.0 3.1 3 0 0 3 3 3 0 RNA binding motif PHM7_cyt PF14703.6 EFX02982.1 - 0.069 13.4 1.6 0.97 9.6 0.0 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Atg14 PF10186.9 EFX02982.1 - 0.38 9.8 3.5 0.71 8.9 3.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-CCCH_2 PF14608.6 EFX02982.1 - 0.4 11.2 4.5 0.71 10.4 4.5 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF3395 PF11875.8 EFX02982.1 - 2.4 8.0 7.9 6.4 6.6 7.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) HIP1_clath_bdg PF16515.5 EFX02982.1 - 3.9 8.2 19.1 0.029 15.0 8.9 2.5 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Arm-DNA-bind_5 PF17293.2 EFX02982.1 - 7.3 7.1 7.1 22 5.6 7.1 1.7 1 0 0 1 1 1 0 Arm DNA-binding domain HTH_AsnC-type PF13404.6 EFX02983.1 - 0.048 13.5 0.1 0.15 12.0 0.1 1.8 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Arrestin_N PF00339.29 EFX02984.1 - 1.4e-11 44.6 0.0 5e-10 39.6 0.0 3.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Cwf_Cwc_15 PF04889.12 EFX02984.1 - 0.00074 19.3 1.4 0.00074 19.3 1.4 2.0 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 EFX02984.1 - 0.086 12.5 0.2 0.086 12.5 0.2 1.9 2 0 0 2 2 2 0 FAM176 family DUF2112 PF09885.9 EFX02984.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2112) Bul1_C PF04426.12 EFX02984.1 - 0.16 11.4 0.4 0.43 10.0 0.0 1.9 2 0 0 2 2 2 0 Bul1 C terminus JAB PF01398.21 EFX02985.1 - 5.6e-28 97.3 0.0 8.2e-28 96.8 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EFX02985.1 - 1.3e-16 61.3 0.1 2.1e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EFX02985.1 - 0.0028 17.4 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain FAD_binding_3 PF01494.19 EFX02986.1 - 7.8e-08 31.9 0.3 0.0011 18.2 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain Metallophos PF00149.28 EFX02987.1 - 8.5e-32 111.3 0.0 3.9e-22 79.8 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFX02987.1 - 0.037 14.5 0.1 0.095 13.2 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain WD40 PF00400.32 EFX02988.1 - 1.9e-10 41.1 1.9 0.00067 20.4 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX02988.1 - 0.0021 18.3 0.1 6.8 7.1 0.0 3.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Fungal_trans PF04082.18 EFX02989.1 - 7.8e-20 71.0 0.0 1.5e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02989.1 - 2.5e-07 30.7 10.3 4.6e-07 29.9 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4719 PF15843.5 EFX02989.1 - 2.6 8.1 8.3 5 7.2 4.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4719) End3 PF12761.7 EFX02990.1 - 5.1e-75 252.0 0.4 5.1e-75 252.0 0.4 1.8 2 0 0 2 2 2 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EFX02990.1 - 6e-47 157.9 0.0 2e-46 156.2 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EFX02990.1 - 9e-07 28.0 0.2 1.9e-06 27.0 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EFX02990.1 - 0.00035 21.0 0.0 0.00086 19.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFX02990.1 - 0.0028 17.5 0.3 0.0079 16.1 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 EFX02990.1 - 0.005 16.7 0.1 0.016 15.0 0.2 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EFX02990.1 - 0.067 12.7 0.1 0.16 11.5 0.1 1.6 1 0 0 1 1 1 0 EF hand IDEAL PF08858.10 EFX02990.1 - 2 8.2 4.7 4.2 7.2 0.7 2.9 2 0 0 2 2 2 0 IDEAL domain Fungal_trans_2 PF11951.8 EFX02991.1 - 1.5e-14 53.6 5.1 3.7e-09 35.9 0.1 2.9 1 1 1 2 2 2 2 Fungal specific transcription factor domain AA_permease PF00324.21 EFX02992.1 - 6.5e-114 381.2 43.3 8.3e-114 380.8 43.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX02992.1 - 1.9e-23 83.0 47.2 2.4e-23 82.7 47.2 1.0 1 0 0 1 1 1 1 Amino acid permease Smim3 PF17307.2 EFX02992.1 - 0.22 11.0 2.4 0.97 9.0 2.4 2.1 1 0 0 1 1 1 0 Small integral membrane protein 3 Fungal_trans PF04082.18 EFX02993.1 - 8.3e-36 123.4 0.0 1.3e-35 122.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX02993.1 - 1.6e-08 34.5 6.7 3.7e-08 33.3 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHD PF00628.29 EFX02993.1 - 0.34 10.9 5.3 0.2 11.6 3.2 1.7 2 0 0 2 2 2 0 PHD-finger ABC_tran PF00005.27 EFX02994.1 - 3.6e-20 72.9 0.0 2.9e-19 69.9 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EFX02994.1 - 8.3e-15 55.2 2.6 1.4e-14 54.4 2.6 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SbcCD_C PF13558.6 EFX02994.1 - 0.00022 21.4 0.1 0.11 12.7 0.0 2.7 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EFX02994.1 - 0.00082 18.9 0.0 0.015 14.7 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain DUF1700 PF08006.11 EFX02994.1 - 0.063 12.8 0.1 0.063 12.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Rab5ip PF07019.12 EFX02994.1 - 4.7 7.9 8.2 0.19 12.3 1.5 2.1 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Forkhead PF00250.18 EFX02995.1 - 1.6e-33 114.8 0.0 3.7e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain Abhydro_lipase PF04083.16 EFX02996.1 - 0.00059 19.4 0.0 0.0026 17.3 0.0 2.0 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFX02996.1 - 0.0035 17.0 0.0 0.0093 15.6 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX02996.1 - 0.01 15.1 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Oxysterol_BP PF01237.18 EFX02996.1 - 0.15 10.8 0.9 0.28 10.0 0.9 1.3 1 0 0 1 1 1 0 Oxysterol-binding protein Pep3_Vps18 PF05131.14 EFX02997.1 - 1.2e-46 158.3 0.0 3.5e-46 156.7 0.0 1.9 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EFX02997.1 - 2.3e-07 30.8 5.4 2.8e-06 27.3 0.1 3.7 4 0 0 4 4 4 1 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 EFX02997.1 - 0.00022 21.0 0.5 0.0005 19.9 0.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX02997.1 - 0.00028 20.8 1.8 0.0003 20.7 0.4 1.7 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFX02997.1 - 0.0004 19.9 0.1 0.00081 19.0 0.1 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EFX02997.1 - 0.0008 19.7 0.6 0.0018 18.6 0.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFX02997.1 - 0.0028 17.4 6.1 0.0031 17.2 3.5 2.2 2 0 0 2 2 2 1 RING-like zinc finger DUF2175 PF09943.9 EFX02997.1 - 0.0064 16.8 0.3 0.019 15.2 0.1 1.9 2 0 0 2 2 1 1 Uncharacterized protein conserved in archaea (DUF2175) Vps39_2 PF10367.9 EFX02997.1 - 0.013 15.9 0.0 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-RING_UBOX PF13445.6 EFX02997.1 - 0.015 15.3 0.6 0.035 14.1 0.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFX02997.1 - 0.11 12.8 0.2 0.26 11.6 0.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DNA_pol3_theta PF06440.11 EFX02997.1 - 0.14 11.8 0.2 0.57 9.9 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase III, theta subunit zf-C3H2C3 PF17122.5 EFX02997.1 - 0.25 11.4 5.5 0.037 14.1 1.3 1.8 2 0 0 2 2 2 0 Zinc-finger zf-C3HC4 PF00097.25 EFX02997.1 - 0.53 10.2 3.3 0.17 11.8 0.2 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Bul1_C PF04426.12 EFX02999.1 - 0.003 17.0 0.0 0.0066 15.9 0.0 1.6 1 0 0 1 1 1 1 Bul1 C terminus Arrestin_N PF00339.29 EFX02999.1 - 0.013 15.6 0.0 0.027 14.5 0.0 1.7 1 1 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Bul1_N PF04425.12 EFX02999.1 - 0.017 13.9 0.1 8.4 5.0 0.0 3.0 2 1 1 3 3 3 0 Bul1 N terminus SSF PF00474.17 EFX03000.1 - 3.3e-06 26.2 30.0 1.3e-05 24.3 29.8 2.1 1 1 0 1 1 1 1 Sodium:solute symporter family BcrAD_BadFG PF01869.20 EFX03001.1 - 1.4e-22 80.5 1.2 1.7e-22 80.2 1.2 1.1 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Ras PF00071.22 EFX03002.1 - 1.6e-59 200.1 0.3 1.9e-59 199.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX03002.1 - 1.8e-20 73.4 0.0 2.6e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX03002.1 - 2.5e-08 33.6 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFX03002.1 - 5e-06 26.2 0.2 2.4e-05 23.9 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFX03002.1 - 0.00015 21.7 0.5 0.6 10.0 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFX03002.1 - 0.0016 18.5 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX03002.1 - 0.0039 16.7 0.0 0.0074 15.8 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EFX03002.1 - 0.0046 16.9 0.0 0.0089 16.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 EFX03002.1 - 0.15 11.8 1.6 1.9 8.2 0.0 2.1 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Ras PF00071.22 EFX03003.1 - 5.4e-64 214.7 0.0 8e-64 214.1 0.0 1.2 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFX03003.1 - 4.4e-34 117.3 0.1 1.1e-33 116.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX03003.1 - 5.8e-13 48.7 0.0 7.4e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFX03003.1 - 9.5e-06 25.3 0.0 2.5e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFX03003.1 - 0.00021 20.7 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFX03003.1 - 0.0016 18.5 0.0 0.0079 16.3 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFX03003.1 - 0.0037 17.2 0.1 2.7 7.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EFX03003.1 - 0.026 14.0 0.0 0.14 11.6 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 EFX03003.1 - 0.11 12.7 0.1 0.76 10.1 0.0 2.1 1 1 0 2 2 2 0 AAA domain RRM_1 PF00076.22 EFX03004.1 - 6e-16 58.0 0.0 8.9e-16 57.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MKT1_C PF12246.8 EFX03005.1 - 2.7e-62 210.2 0.0 3.6e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EFX03005.1 - 1.6e-28 98.9 0.1 4.6e-28 97.4 0.1 1.9 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EFX03005.1 - 0.005 17.3 0.0 0.015 15.8 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain TcdA_TcdB_pore PF12920.7 EFX03005.1 - 0.043 12.1 0.0 0.066 11.5 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain Myb_DNA-binding PF00249.31 EFX03007.1 - 0.00043 20.4 0.6 0.013 15.7 0.1 3.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain BUD22 PF09073.10 EFX03007.1 - 0.19 11.0 33.0 0.05 12.9 6.0 2.2 2 0 0 2 2 2 0 BUD22 SpoIIIAH PF12685.7 EFX03007.1 - 0.28 11.0 14.3 1.6 8.5 6.9 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein CDC45 PF02724.14 EFX03007.1 - 0.87 7.8 33.0 1.2 7.4 6.7 2.2 2 0 0 2 2 2 0 CDC45-like protein BSP_II PF05432.11 EFX03007.1 - 2 8.0 35.6 0.49 10.1 10.7 2.6 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 EFX03007.1 - 2.3 7.6 39.7 2.6 7.4 17.7 2.4 2 0 0 2 2 2 0 SDA1 MFMR_assoc PF16596.5 EFX03007.1 - 3.8 8.0 8.9 10 6.6 8.9 1.7 1 0 0 1 1 1 0 Disordered region downstream of MFMR Nop14 PF04147.12 EFX03007.1 - 4.7 5.3 39.7 2.3 6.3 12.2 2.1 2 0 0 2 2 2 0 Nop14-like family DNA_pol_phi PF04931.13 EFX03007.1 - 5.2 5.0 52.5 0.15 10.1 16.0 2.2 2 0 0 2 2 2 0 DNA polymerase phi Ferric_reduct PF01794.19 EFX03008.1 - 6.3e-24 84.5 8.2 6.3e-24 84.5 8.2 2.3 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFX03008.1 - 4.7e-22 78.8 0.0 1.8e-14 54.2 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFX03008.1 - 9e-10 38.6 0.0 8.3e-08 32.3 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFX03008.1 - 0.02 15.5 0.0 0.063 13.9 0.0 1.9 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Thiolase_N PF00108.23 EFX03009.1 - 1.5e-87 293.3 1.3 3e-87 292.3 1.3 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFX03009.1 - 4.1e-38 129.8 0.7 4.1e-38 129.8 0.7 2.3 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFX03009.1 - 1.4e-05 24.9 1.1 1.4e-05 24.9 1.1 2.8 3 1 1 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain Chal_sti_synt_N PF00195.19 EFX03009.1 - 0.032 13.7 0.5 0.078 12.4 0.0 1.9 2 0 0 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 EFX03009.1 - 0.81 9.6 7.0 2.2 8.2 0.1 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YjeF_N PF03853.15 EFX03011.1 - 4.4e-36 124.3 0.1 8.1e-36 123.5 0.1 1.5 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EFX03011.1 - 5.6e-07 30.4 0.0 5.6e-07 30.4 0.0 2.7 4 0 0 4 4 4 1 FDF domain UDPG_MGDP_dh_N PF03721.14 EFX03012.1 - 4.8e-48 163.2 0.1 4.7e-47 160.0 0.1 2.3 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EFX03012.1 - 5.7e-29 100.2 0.1 1.4e-28 99.0 0.1 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EFX03012.1 - 5.1e-21 75.1 0.2 3.6e-16 59.5 0.0 3.4 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 EFX03012.1 - 0.0003 21.0 0.2 0.012 15.8 0.0 3.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EFX03012.1 - 0.076 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PIG-F PF06699.11 EFX03013.1 - 4.1e-48 163.9 5.4 5.9e-48 163.4 5.4 1.2 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Peptidase_S9 PF00326.21 EFX03014.1 - 9.5e-35 120.0 0.3 2e-34 119.0 0.3 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family NuA4 PF09340.10 EFX03014.1 - 3.4e-25 87.7 0.5 6.1e-25 86.9 0.5 1.5 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 PD40 PF07676.12 EFX03014.1 - 0.0018 18.1 0.2 0.013 15.4 0.1 2.4 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat AXE1 PF05448.12 EFX03014.1 - 0.023 13.4 0.5 0.41 9.3 0.5 2.3 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) LRR_8 PF13855.6 EFX03015.1 - 6.4e-10 38.6 0.0 3.3e-05 23.6 0.1 3.1 2 1 1 3 3 3 3 Leucine rich repeat Pkinase_Tyr PF07714.17 EFX03015.1 - 4.5e-09 36.0 0.0 2.8e-07 30.1 0.0 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase LRR_4 PF12799.7 EFX03015.1 - 2.3e-06 27.8 0.1 0.71 10.4 0.0 3.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) Pkinase PF00069.25 EFX03015.1 - 5.3e-06 26.0 0.4 2e-05 24.1 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Kdo PF06293.14 EFX03015.1 - 3e-05 23.5 0.0 6.3e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_9 PF14580.6 EFX03015.1 - 0.029 13.9 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat APH PF01636.23 EFX03015.1 - 0.057 13.3 4.7 0.32 10.9 0.0 3.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family GP46 PF07409.12 EFX03015.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Phage protein GP46 Pkinase_fungal PF17667.1 EFX03015.1 - 0.32 9.7 1.7 0.28 9.9 0.1 1.6 2 0 0 2 2 2 0 Fungal protein kinase LRR_1 PF00560.33 EFX03015.1 - 0.46 11.2 1.8 24 6.0 0.0 3.8 3 2 0 3 3 3 0 Leucine Rich Repeat RRM_1 PF00076.22 EFX03016.1 - 3.9e-52 174.0 0.1 5e-17 61.5 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFX03016.1 - 4.2e-32 109.8 0.0 5.2e-24 83.9 0.0 4.3 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM_5 PF13893.6 EFX03016.1 - 2.3e-11 43.4 0.0 0.001 18.6 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFX03016.1 - 1.7e-06 27.9 0.1 0.25 11.4 0.0 3.6 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFX03016.1 - 0.0004 20.5 0.0 0.86 9.8 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif Lsm_interact PF05391.11 EFX03016.1 - 0.0022 17.4 0.0 0.005 16.3 0.0 1.6 1 0 0 1 1 1 1 Lsm interaction motif Nup35_RRM PF05172.13 EFX03016.1 - 0.034 14.1 0.0 0.34 10.9 0.0 2.7 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RL PF17797.1 EFX03016.1 - 0.074 13.0 1.7 0.077 13.0 0.0 1.9 2 0 0 2 2 2 0 RL domain Limkain-b1 PF11608.8 EFX03016.1 - 6.9 6.8 7.6 6.8 6.8 0.0 4.4 5 0 0 5 5 5 0 Limkain b1 Ribonuclease_3 PF00636.26 EFX03018.1 - 7.4e-43 145.5 0.0 1.3e-20 74.0 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFX03018.1 - 5.8e-23 81.5 0.4 3.5e-11 43.4 0.0 4.4 4 0 0 4 4 4 2 Ribonuclease-III-like ResIII PF04851.15 EFX03018.1 - 2e-13 50.7 0.1 4.3e-13 49.6 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFX03018.1 - 3.3e-10 40.0 0.0 6.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4080 PF13311.6 EFX03018.1 - 0.013 15.7 0.2 7.7 6.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) SecA_DEAD PF07517.14 EFX03018.1 - 0.11 11.8 0.1 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain Flavi_DEAD PF07652.14 EFX03018.1 - 0.15 12.0 0.2 0.98 9.4 0.1 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain CPSase_L_D2 PF02786.17 EFX03019.1 - 1.1e-111 371.4 0.2 2e-83 279.1 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EFX03019.1 - 1.7e-46 157.2 0.0 3.8e-46 156.1 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EFX03019.1 - 5.3e-46 156.8 0.0 1.1e-45 155.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EFX03019.1 - 2.3e-43 147.7 0.0 5.9e-43 146.4 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EFX03019.1 - 1.4e-38 132.0 0.0 2.9e-38 130.9 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EFX03019.1 - 7.4e-27 94.4 0.0 2.1e-26 92.9 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EFX03019.1 - 1.7e-21 76.2 0.0 5.7e-21 74.5 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EFX03019.1 - 1.1e-17 64.3 1.0 2.7e-08 33.6 0.1 3.0 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFX03019.1 - 2.2e-16 59.9 0.1 6e-08 32.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EFX03019.1 - 1.4e-09 37.8 0.0 0.00013 21.7 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EFX03019.1 - 9.6e-06 25.5 0.1 0.0012 18.6 0.1 2.6 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 EFX03019.1 - 2.2e-05 24.5 0.2 0.067 13.2 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain DJ-1_PfpI PF01965.24 EFX03019.1 - 7.4e-05 22.6 0.5 0.061 13.1 0.0 4.2 4 0 0 4 4 4 1 DJ-1/PfpI family GARS_A PF01071.19 EFX03019.1 - 0.003 17.4 0.2 1.6 8.5 0.0 3.0 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Ribonuc_L-PSP PF01042.21 EFX03020.1 - 7.5e-39 132.5 0.0 9.8e-39 132.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Peptidase_S8 PF00082.22 EFX03022.1 - 1.9e-13 50.4 1.6 3.2e-13 49.6 1.6 1.3 1 0 0 1 1 1 1 Subtilase family CdhD PF03599.16 EFX03022.1 - 0.11 11.2 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit ATP_bind_1 PF03029.17 EFX03023.1 - 2.5e-77 259.9 0.0 3.1e-77 259.6 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EFX03023.1 - 0.0015 17.5 0.0 0.0034 16.4 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 EFX03023.1 - 0.013 15.4 0.0 1.5 8.7 0.0 2.4 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFX03023.1 - 0.018 14.3 0.0 0.057 12.7 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin CLP1_P PF16575.5 EFX03023.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.6 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 EFX03023.1 - 0.13 12.4 0.0 2.5 8.2 0.0 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFX03023.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1752 PF08550.10 EFX03024.1 - 6.8e-12 45.0 5.2 1.4e-11 44.0 5.2 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) PI3K_1B_p101 PF10486.9 EFX03024.1 - 1 7.1 7.5 0.053 11.3 0.7 2.0 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PBP1_TM PF14812.6 EFX03024.1 - 2.8 8.4 7.1 24 5.4 0.6 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAD_binding_4 PF01565.23 EFX03025.1 - 3.8e-12 46.1 0.4 6.5e-12 45.4 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 EFX03025.1 - 1.1e-05 25.4 0.2 1.9e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase PhageMin_Tail PF10145.9 EFX03026.1 - 0.0045 16.9 3.1 0.0088 15.9 3.1 1.4 1 0 0 1 1 1 1 Phage-related minor tail protein FlgN PF05130.12 EFX03026.1 - 0.02 15.4 4.0 0.02 15.4 4.0 1.8 1 1 0 1 1 1 0 FlgN protein SHE3 PF17078.5 EFX03026.1 - 0.041 13.6 2.0 0.063 13.0 2.0 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Exonuc_VII_S PF02609.16 EFX03026.1 - 0.051 13.6 1.7 0.056 13.5 0.3 1.8 2 0 0 2 2 1 0 Exonuclease VII small subunit F_actin_bind PF08919.10 EFX03026.1 - 0.065 13.3 1.4 0.13 12.4 0.3 2.0 3 0 0 3 3 3 0 F-actin binding Phage_lysis PF03245.13 EFX03026.1 - 0.099 12.8 10.7 1.5 9.0 5.0 2.6 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein UPF0242 PF06785.11 EFX03026.1 - 0.13 12.4 1.7 0.2 11.7 1.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Urocanase PF01175.18 EFX03026.1 - 0.15 11.7 2.3 1.7 8.3 0.5 2.3 1 1 1 2 2 2 0 Urocanase Rossmann-like domain DUF4763 PF15960.5 EFX03026.1 - 0.2 10.9 4.9 0.45 9.8 2.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Rootletin PF15035.6 EFX03026.1 - 0.42 10.6 15.3 1.2 9.1 15.3 1.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Fib_alpha PF08702.10 EFX03026.1 - 0.42 10.8 2.2 0.89 9.7 0.8 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PRKG1_interact PF15898.5 EFX03026.1 - 1.4 9.8 7.2 2.4 9.1 0.7 2.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain CRF PF00473.17 EFX03026.1 - 1.6 8.8 4.9 5.9 7.1 0.0 3.3 3 0 0 3 3 3 0 Corticotropin-releasing factor family SlyX PF04102.12 EFX03026.1 - 2.1 9.0 9.7 1.9 9.2 0.1 3.8 2 1 2 4 4 4 0 SlyX Met_10 PF02475.16 EFX03027.1 - 1.1e-64 217.8 0.0 1.6e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein zf-C2H2 PF00096.26 EFX03028.1 - 0.01 16.3 3.2 0.01 16.3 3.2 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type ELO PF01151.18 EFX03029.1 - 5.8e-62 209.4 18.6 7e-62 209.2 18.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PTPA PF03095.15 EFX03030.1 - 1.5e-106 356.3 0.0 1.8e-106 356.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pmp3 PF01679.17 EFX03032.1 - 3.2e-19 68.8 8.2 4e-19 68.5 8.2 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator F-box PF00646.33 EFX03033.1 - 0.00017 21.4 0.2 0.00059 19.7 0.2 2.0 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFX03033.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 F-box TatD_DNase PF01026.21 EFX03034.1 - 9.8e-32 110.3 0.0 1.4e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase PC4 PF02229.16 EFX03035.1 - 6.7e-23 80.1 0.1 1e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) ComZ PF10815.8 EFX03035.1 - 0.13 12.3 0.3 0.99 9.5 0.1 2.1 1 1 1 2 2 2 0 ComZ Pkinase PF00069.25 EFX03036.1 - 1.4e-67 227.8 0.0 1.9e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03036.1 - 1.7e-38 132.4 0.0 2.3e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EFX03036.1 - 2.5e-06 27.6 0.0 0.0013 18.9 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EFX03036.1 - 2.8e-06 26.9 0.0 4.3e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFX03036.1 - 0.00046 19.6 0.0 0.00085 18.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFX03036.1 - 0.041 12.7 0.2 0.041 12.7 0.2 2.4 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 EFX03036.1 - 0.044 12.7 0.0 0.044 12.7 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain FxsA PF04186.13 EFX03037.1 - 0.07 13.3 0.7 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein GREB1 PF15782.5 EFX03037.1 - 7.3 3.6 5.1 9.5 3.2 5.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Glyco_hydro_28 PF00295.17 EFX03038.1 - 1.7e-26 93.0 4.4 2.3e-26 92.6 4.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 EFX03038.1 - 6.6e-06 26.1 10.3 1e-05 25.5 9.4 1.9 1 1 0 1 1 1 1 Pectate lyase superfamily protein INSIG PF07281.12 EFX03039.1 - 6.2e-80 267.8 5.2 1e-79 267.1 4.3 1.7 2 0 0 2 2 2 1 Insulin-induced protein (INSIG) Nepo_coat PF03391.15 EFX03039.1 - 0.6 9.6 8.6 0.58 9.6 4.7 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, central domain Adeno_PV PF03910.13 EFX03039.1 - 2.9 6.5 7.7 1.2 7.7 2.8 2.1 2 0 0 2 2 2 0 Adenovirus minor core protein PV Toxin_16 PF07945.11 EFX03040.1 - 0.84 9.6 8.2 0.66 9.9 2.6 2.7 2 0 0 2 2 2 0 Janus-atracotoxin BRCT PF00533.26 EFX03041.1 - 9e-05 22.8 0.0 0.0002 21.7 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFX03041.1 - 0.0071 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EFX03041.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EFX03041.1 - 0.19 11.8 0.0 16 5.7 0.0 2.3 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain p450 PF00067.22 EFX03043.1 - 2.9e-48 164.8 0.0 7.5e-48 163.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 AA_permease_2 PF13520.6 EFX03044.1 - 2.4e-43 148.5 45.0 1.1e-28 100.2 18.6 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EFX03044.1 - 2.8e-20 72.4 41.4 7.1e-11 41.4 21.5 2.5 1 1 1 2 2 2 2 Amino acid permease Longin PF13774.6 EFX03045.1 - 8.2e-30 102.7 0.0 1.3e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EFX03045.1 - 3.1e-28 97.4 0.0 4.4e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Abhydrolase_3 PF07859.13 EFX03046.1 - 2.5e-40 138.6 0.3 3.4e-30 105.5 0.0 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFX03046.1 - 2.7e-11 43.0 0.0 8.2e-11 41.4 0.0 1.7 2 0 0 2 2 2 1 Steryl acetyl hydrolase COesterase PF00135.28 EFX03046.1 - 0.014 14.3 0.1 0.19 10.6 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family Hydrolase_4 PF12146.8 EFX03046.1 - 0.096 11.9 0.1 0.28 10.4 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Glyco_hydro_28 PF00295.17 EFX03047.1 - 4.3e-22 78.6 4.5 5.9e-22 78.1 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 EFX03047.1 - 0.0023 17.8 15.0 0.1 12.4 13.7 3.2 2 1 0 2 2 2 1 Pectate lyase superfamily protein p450 PF00067.22 EFX03048.1 - 4.3e-27 95.0 0.0 6.9e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Pyridoxal_deC PF00282.19 EFX03049.1 - 1.3e-91 307.1 0.0 1.7e-91 306.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain ThiF PF00899.21 EFX03050.1 - 3.1e-17 62.8 0.0 3.5e-15 56.0 0.0 2.5 2 1 1 3 3 3 2 ThiF family Sel_put PF04328.13 EFX03050.1 - 0.033 14.2 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 Selenoprotein, putative E1_4HB PF16191.5 EFX03050.1 - 0.053 13.7 0.1 0.18 12.0 0.1 2.0 1 1 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle Virul_fac_BrkB PF03631.15 EFX03050.1 - 0.25 10.9 0.0 2.3 7.7 0.0 2.0 2 0 0 2 2 2 0 Virulence factor BrkB Complex1_LYR PF05347.15 EFX03051.1 - 4.8e-21 74.6 4.8 6.3e-21 74.2 4.8 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFX03051.1 - 3.1e-06 27.8 2.2 3.6e-06 27.6 2.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EFX03051.1 - 0.00022 21.8 1.4 0.00027 21.5 1.4 1.3 1 1 0 1 1 1 1 Complex1_LYR-like ChapFlgA PF13144.6 EFX03051.1 - 0.087 12.9 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Chaperone for flagella basal body P-ring formation VitD-bind_III PF09164.10 EFX03051.1 - 0.12 12.3 0.1 0.2 11.7 0.1 1.2 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Ribosomal_S13_N PF08069.12 EFX03052.1 - 1e-25 89.6 0.1 2.4e-25 88.3 0.1 1.7 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain RRM_1 PF00076.22 EFX03052.1 - 1.7e-25 88.6 0.0 4.5e-13 48.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S15 PF00312.22 EFX03052.1 - 7.4e-15 54.9 0.1 1.6e-14 53.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 RRM_occluded PF16842.5 EFX03052.1 - 0.00037 20.3 0.1 0.14 12.0 0.0 3.4 3 0 0 3 3 3 1 Occluded RNA-recognition motif PAX PF00292.18 EFX03052.1 - 0.048 13.6 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 'Paired box' domain TPR_12 PF13424.6 EFX03053.1 - 0.00046 20.4 0.5 0.63 10.4 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX03053.1 - 0.21 11.5 1.0 1.3 9.0 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat APG5 PF04106.12 EFX03054.1 - 1e-47 162.6 0.0 2.9e-47 161.2 0.0 1.6 1 1 0 1 1 1 1 Autophagy protein Apg5 CorA PF01544.18 EFX03055.1 - 6.1e-12 45.4 0.0 1.4e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.16 EFX03056.1 - 2e-32 112.5 32.7 1.2e-31 110.0 14.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFX03056.1 - 0.00023 20.6 0.1 0.00023 20.6 0.1 2.9 2 1 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF4199 PF13858.6 EFX03056.1 - 0.012 16.0 6.9 0.019 15.3 0.3 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF4199) Nse4_C PF08743.10 EFX03057.1 - 2.7e-33 114.1 0.0 7.6e-33 112.6 0.0 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EFX03057.1 - 2.4e-11 43.6 0.1 2.4e-11 43.6 0.1 3.3 3 1 0 3 3 3 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF371 PF04027.13 EFX03057.1 - 0.11 12.5 0.5 0.23 11.5 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF371) Peroxin-3 PF04882.12 EFX03058.1 - 5.7e-158 526.8 0.0 6.7e-158 526.6 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 DUF4088 PF13317.6 EFX03058.1 - 0.11 12.0 1.1 0.21 11.1 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Nab2 PF11517.8 EFX03059.1 - 0.012 15.9 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.6 EFX03059.1 - 0.018 15.5 6.7 0.018 15.5 6.7 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF4175 PF13779.6 EFX03059.1 - 0.32 8.8 17.7 0.58 8.0 17.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Spt20 PF12090.8 EFX03059.1 - 6.4 6.3 8.0 11 5.5 8.0 1.3 1 0 0 1 1 1 0 Spt20 family AAA_33 PF13671.6 EFX03060.1 - 0.00052 20.2 0.0 0.0031 17.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX03060.1 - 0.0022 18.3 0.0 0.0041 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFX03060.1 - 0.0027 17.5 0.0 0.51 10.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFX03060.1 - 0.025 15.0 0.0 0.075 13.4 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EFX03060.1 - 0.035 14.5 0.2 0.39 11.1 0.2 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFX03060.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 EFX03060.1 - 0.14 11.1 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Sugar_tr PF00083.24 EFX03061.1 - 1.2e-122 410.0 25.2 1.4e-122 409.8 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03061.1 - 3.5e-19 68.9 62.5 6.8e-17 61.4 33.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EFX03062.1 - 1e-47 162.8 34.7 1e-47 162.8 34.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03062.1 - 5.1e-06 25.6 20.7 1.4e-05 24.1 20.5 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EFX03062.1 - 0.0088 14.5 1.7 0.013 13.9 1.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EFX03062.1 - 0.13 10.5 6.5 0.076 11.3 3.6 2.1 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Pneumo_att_G PF05539.11 EFX03062.1 - 2 7.9 3.7 2.8 7.4 3.7 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Glyco_hydro_88 PF07470.13 EFX03063.1 - 1.8e-87 293.7 0.1 2e-87 293.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 EF_assoc_1 PF08355.12 EFX03064.1 - 5.2e-31 106.1 0.2 1.3e-30 104.8 0.2 1.7 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.12 EFX03064.1 - 3.6e-28 97.4 0.0 1.3e-27 95.6 0.0 2.0 1 1 0 1 1 1 1 EF hand associated Ras PF00071.22 EFX03064.1 - 4.1e-16 59.0 0.0 7.3e-12 45.2 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFX03064.1 - 3.4e-11 43.4 0.0 1.1e-07 32.1 0.0 2.9 3 0 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 EFX03064.1 - 2.3e-10 40.9 5.9 0.00061 20.6 0.5 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat MMR_HSR1 PF01926.23 EFX03064.1 - 8.9e-07 29.0 0.0 0.005 16.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 EFX03064.1 - 5.8e-06 25.5 2.7 0.057 13.0 0.4 2.9 2 0 0 2 2 2 2 EF hand ANAPC4_WD40 PF12894.7 EFX03064.1 - 9.4e-06 25.8 0.0 0.6 10.5 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_7 PF13499.6 EFX03064.1 - 2e-05 24.9 0.1 0.027 14.9 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFX03064.1 - 4.6e-05 23.0 2.6 0.14 12.1 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain AAA_29 PF13555.6 EFX03064.1 - 8.3e-05 22.3 0.0 0.044 13.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFX03064.1 - 0.00014 22.2 0.0 0.22 11.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFX03064.1 - 0.00087 19.6 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EFX03064.1 - 0.00088 19.8 0.0 1.6 9.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter Dynamin_N PF00350.23 EFX03064.1 - 0.00088 19.4 0.1 1.9 8.5 0.1 2.9 2 1 1 3 3 3 2 Dynamin family Ploopntkinase3 PF18751.1 EFX03064.1 - 0.0038 17.1 0.0 0.12 12.3 0.0 2.3 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 RsgA_GTPase PF03193.16 EFX03064.1 - 0.016 15.1 0.0 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 EFX03064.1 - 0.017 15.5 0.0 1.5 9.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EFX03064.1 - 0.023 15.0 0.0 9.7 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFX03064.1 - 0.027 14.6 0.0 4.7 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFX03064.1 - 0.03 14.0 0.0 0.59 9.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EFX03064.1 - 0.051 13.5 0.1 7.6 6.4 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EFX03064.1 - 0.098 12.2 0.0 14 5.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFX03064.1 - 0.12 11.9 0.0 0.84 9.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region IKI3 PF04762.12 EFX03064.1 - 0.18 9.8 0.0 0.26 9.2 0.0 1.1 1 0 0 1 1 1 0 IKI3 family Viral_helicase1 PF01443.18 EFX03064.1 - 0.2 11.4 0.0 4.8 6.9 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase EF-hand_10 PF14788.6 EFX03064.1 - 0.22 11.4 0.8 0.5 10.3 0.2 1.8 2 0 0 2 2 2 0 EF hand Septin PF00735.18 EFX03064.1 - 0.24 10.7 0.0 0.85 8.8 0.0 1.8 2 0 0 2 2 2 0 Septin EF-hand_8 PF13833.6 EFX03064.1 - 0.25 11.2 3.3 1.6 8.6 0.8 2.4 2 0 0 2 2 2 0 EF-hand domain pair Peptidase_C2 PF00648.21 EFX03067.1 - 1.1e-62 211.8 0.4 1.6e-61 207.9 0.4 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease ATP13 PF12921.7 EFX03067.1 - 0.076 12.9 0.1 9.5 6.1 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial ATPase expression PPR PF01535.20 EFX03067.1 - 0.2 12.0 0.1 7.3 7.1 0.1 3.6 6 0 0 6 6 6 0 PPR repeat Methyltransf_11 PF08241.12 EFX03068.1 - 6e-09 36.4 0.0 1.1e-08 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03068.1 - 1.2e-07 32.3 0.0 2.4e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03068.1 - 6.1e-05 23.7 0.0 0.00012 22.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03068.1 - 0.0026 17.6 0.0 0.0034 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX03068.1 - 0.074 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF4081 PF13312.6 EFX03068.1 - 0.15 12.2 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) MFS_1 PF07690.16 EFX03069.1 - 6.7e-27 94.3 45.6 2.9e-26 92.3 45.6 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03069.1 - 1.9e-10 40.2 10.6 1.9e-10 40.2 10.6 3.0 2 1 0 3 3 3 1 Sugar (and other) transporter SpoIIIAH PF12685.7 EFX03069.1 - 0.083 12.7 3.7 0.13 12.0 3.7 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein OATP PF03137.20 EFX03069.1 - 0.61 8.3 9.6 1.3 7.2 2.6 2.7 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Profilin PF00235.19 EFX03070.1 - 3.3e-43 147.0 0.5 3.6e-43 146.8 0.5 1.0 1 0 0 1 1 1 1 Profilin DUF4815 PF16075.5 EFX03070.1 - 0.042 12.1 0.1 0.051 11.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) Cyt-b5 PF00173.28 EFX03072.1 - 3e-18 65.7 0.1 9.8e-18 64.1 0.1 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 EFX03072.1 - 1.7e-17 64.1 16.5 1.7e-17 64.1 16.5 2.0 1 1 1 2 2 2 1 Fatty acid desaturase zf-C4H2 PF10146.9 EFX03073.1 - 0.011 16.1 0.6 0.011 16.1 0.6 2.6 2 1 1 3 3 3 0 Zinc finger-containing protein GIT_CC PF16559.5 EFX03073.1 - 0.078 12.9 0.6 0.29 11.0 0.6 2.0 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 EFX03073.1 - 0.085 13.5 1.9 16 6.2 0.2 2.8 2 0 0 2 2 2 0 Initiation control protein YabA NYD-SP28_assoc PF14775.6 EFX03073.1 - 0.23 11.6 3.3 0.89 9.7 0.3 2.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF1192 PF06698.11 EFX03073.1 - 1.8 8.7 9.0 0.3 11.2 2.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF1664 PF07889.12 EFX03073.1 - 4.6 7.3 4.7 28 4.8 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BNIP3 PF06553.12 EFX03074.1 - 1.3 8.7 7.1 22 4.6 4.4 2.7 2 0 0 2 2 2 0 BNIP3 Ribosomal_L22e PF01776.17 EFX03075.1 - 3.2e-45 153.0 1.3 3.8e-45 152.7 1.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family START PF01852.19 EFX03075.1 - 0.13 11.7 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 START domain Pectinesterase PF01095.19 EFX03076.1 - 3.9e-36 124.3 6.6 2.7e-30 105.1 2.3 2.1 1 1 1 2 2 2 2 Pectinesterase Sugar_tr PF00083.24 EFX03077.1 - 1.8e-78 264.4 18.1 2.1e-78 264.2 18.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03077.1 - 2.2e-14 53.2 35.7 7.7e-09 34.9 17.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFX03077.1 - 0.12 11.2 16.2 0.012 14.6 4.4 2.2 2 0 0 2 2 2 0 MFS_1 like family CN_hydrolase PF00795.22 EFX03078.1 - 4.3e-33 114.8 0.0 2.3e-24 86.2 0.0 2.2 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase NAD_binding_4 PF07993.12 EFX03079.1 - 4.5e-29 101.4 0.0 1.2e-28 100.0 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EFX03079.1 - 3.3e-25 88.5 0.0 5.5e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EFX03079.1 - 9.8e-10 38.3 0.0 1.8e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EFX03079.1 - 5.1e-06 26.8 0.0 1.2e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site RmlD_sub_bind PF04321.17 EFX03079.1 - 0.002 17.3 0.1 0.031 13.4 0.0 2.3 2 0 0 2 2 2 1 RmlD substrate binding domain KR PF08659.10 EFX03079.1 - 0.017 15.0 0.7 0.18 11.7 0.1 2.7 3 0 0 3 3 3 0 KR domain COX6C PF02937.15 EFX03080.1 - 0.071 13.2 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc ABC_membrane PF00664.23 EFX03081.1 - 3.5e-13 49.8 3.8 6.3e-13 49.0 3.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFX03081.1 - 7.8e-07 29.7 0.0 1.4e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFX03081.1 - 0.0066 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX03081.1 - 0.023 14.1 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Spc24 PF08286.11 EFX03083.1 - 7.8e-39 132.1 0.3 7.4e-36 122.6 0.0 2.2 2 0 0 2 2 2 2 Spc24 subunit of Ndc80 Nsp1_C PF05064.13 EFX03083.1 - 0.0027 17.5 2.2 0.49 10.2 0.0 2.4 2 0 0 2 2 2 1 Nsp1-like C-terminal region Vps5 PF09325.10 EFX03083.1 - 0.018 14.6 3.1 0.026 14.1 3.1 1.3 1 0 0 1 1 1 0 Vps5 C terminal like DUF4208 PF13907.6 EFX03083.1 - 0.038 14.4 0.4 0.077 13.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) DUF5082 PF16888.5 EFX03083.1 - 0.058 13.7 3.0 0.1 12.9 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 EFX03083.1 - 0.082 13.4 11.1 0.13 12.8 11.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 EFX03083.1 - 0.098 10.6 0.2 0.1 10.5 0.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Filo_VP35 PF02097.15 EFX03083.1 - 0.1 11.6 0.4 0.13 11.3 0.4 1.1 1 0 0 1 1 1 0 Filoviridae VP35 Blo-t-5 PF11642.8 EFX03083.1 - 0.11 12.5 1.1 0.22 11.5 1.1 1.5 1 1 0 1 1 1 0 Mite allergen Blo t 5 Prefoldin_2 PF01920.20 EFX03083.1 - 0.17 11.8 7.4 2.1 8.3 1.5 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF3073 PF11273.8 EFX03083.1 - 0.2 12.4 1.1 0.49 11.2 1.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3073) DUF3584 PF12128.8 EFX03083.1 - 0.3 8.6 7.1 0.36 8.3 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 EFX03083.1 - 0.31 11.1 7.0 0.65 10.0 7.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prominin PF05478.11 EFX03083.1 - 0.4 8.6 3.5 0.52 8.2 3.5 1.0 1 0 0 1 1 1 0 Prominin DUF4164 PF13747.6 EFX03083.1 - 0.45 10.8 12.2 9.5 6.6 12.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) Noelin-1 PF12308.8 EFX03083.1 - 0.52 10.3 2.1 0.59 10.1 0.6 1.8 2 0 0 2 2 2 0 Neurogenesis glycoprotein FUSC PF04632.12 EFX03083.1 - 0.56 8.7 6.5 0.71 8.3 6.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family SlyX PF04102.12 EFX03083.1 - 1.3 9.7 8.9 7.9 7.2 0.6 2.5 1 1 1 2 2 2 0 SlyX ABC_tran_CTD PF16326.5 EFX03083.1 - 3.3 8.0 10.3 11 6.3 1.5 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain DSPc PF00782.20 EFX03084.1 - 4.2e-10 39.5 0.0 7.5e-10 38.7 0.0 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EFX03084.1 - 0.02 15.2 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain PNP_phzG_C PF10590.9 EFX03085.1 - 6.9e-21 74.1 0.7 2.9e-20 72.1 1.1 1.9 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EFX03085.1 - 8.8e-12 45.1 0.0 3.1e-11 43.3 0.0 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pkinase PF00069.25 EFX03087.1 - 4.7e-64 216.3 0.0 6.6e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03087.1 - 1.4e-38 132.6 0.0 2e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX03087.1 - 0.00052 18.9 0.0 0.00096 18.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFX03087.1 - 0.0025 17.2 0.0 0.0064 15.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFX03087.1 - 0.028 13.4 0.0 0.048 12.6 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Activator_LAG-3 PF11498.8 EFX03087.1 - 3.1 6.6 11.3 5 6.0 11.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 E1_dh PF00676.20 EFX03088.1 - 1.6e-114 381.9 0.3 2.2e-114 381.5 0.3 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EFX03088.1 - 0.0025 17.1 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PMT PF02366.18 EFX03089.1 - 1e-82 277.5 16.9 2.2e-82 276.4 16.9 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EFX03089.1 - 3.3e-69 232.5 7.7 3.3e-69 232.5 7.7 2.9 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EFX03089.1 - 4.5e-16 59.2 0.0 8e-15 55.2 0.0 2.0 1 1 1 2 2 2 2 MIR domain zf-UBR PF02207.20 EFX03090.1 - 6.8e-14 51.8 5.2 6.8e-14 51.8 5.2 3.5 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) SMK-1 PF04802.15 EFX03091.1 - 4.2e-83 277.9 2.5 1.2e-82 276.4 0.3 2.6 3 0 0 3 3 3 1 Component of IIS longevity pathway SMK-1 NAM-associated PF14303.6 EFX03091.1 - 5.5 7.7 5.7 12 6.5 5.7 1.6 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain TruB_N PF01509.18 EFX03092.1 - 1.3e-42 145.7 0.0 2.7e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EFX03092.1 - 5e-07 29.8 0.0 1.3e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Mito_carr PF00153.27 EFX03093.1 - 1.4e-53 178.8 0.2 1.4e-16 60.1 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_8 PF01501.20 EFX03093.1 - 6.7e-07 29.1 0.0 1.9e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 zf-MIZ PF02891.20 EFX03094.1 - 7.6e-07 28.8 11.8 9.1e-06 25.3 0.0 2.6 1 1 0 2 2 2 1 MIZ/SP-RING zinc finger zf-C3HC4_3 PF13920.6 EFX03094.1 - 0.17 11.8 9.4 0.36 10.7 9.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Hydrolase PF00702.26 EFX03095.1 - 9.8e-06 26.0 0.0 3.1e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFX03095.1 - 0.062 13.4 0.0 0.084 13.0 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HEAT PF02985.22 EFX03096.1 - 1.6e-13 49.7 16.0 0.0012 18.9 0.0 9.7 12 0 0 12 12 12 2 HEAT repeat HEAT_EZ PF13513.6 EFX03096.1 - 8.1e-12 45.4 9.6 6.7e-08 32.9 0.0 7.3 9 1 1 10 10 10 2 HEAT-like repeat HEAT_2 PF13646.6 EFX03096.1 - 1.6e-11 44.4 8.5 0.0014 19.0 0.0 7.1 3 2 2 6 6 6 4 HEAT repeats IBN_N PF03810.19 EFX03096.1 - 5.7e-09 35.8 2.0 5.9e-07 29.3 1.2 3.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain UME PF08064.13 EFX03096.1 - 0.00024 21.0 0.8 1.8 8.5 0.0 5.0 6 0 0 6 6 6 1 UME (NUC010) domain CLASP_N PF12348.8 EFX03096.1 - 0.002 17.8 0.1 14 5.2 0.0 5.0 4 2 2 6 6 6 1 CLASP N terminal DUF3385 PF11865.8 EFX03096.1 - 0.018 14.9 0.0 1.6 8.6 0.0 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3385) Fungal_trans PF04082.18 EFX03097.1 - 2.7e-19 69.2 0.1 4.1e-19 68.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyridox_oxase_2 PF12766.7 EFX03097.1 - 1.3e-17 64.2 0.0 2.5e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Ribosomal_S18 PF01084.20 EFX03098.1 - 5.3e-12 45.8 0.0 9.2e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 DUF1501 PF07394.12 EFX03098.1 - 0.034 13.2 0.5 0.043 12.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) MFS_1 PF07690.16 EFX03099.1 - 2.1e-25 89.4 28.4 5.9e-19 68.2 14.1 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03099.1 - 2.2e-08 33.4 0.1 2.2e-08 33.4 0.1 2.1 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EFX03099.1 - 0.018 13.3 0.3 0.18 10.0 0.3 2.1 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tom22 PF04281.13 EFX03100.1 - 3.2e-46 156.6 0.0 3.7e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 FYVE_2 PF02318.16 EFX03101.1 - 0.0082 16.3 26.0 0.091 13.0 3.1 3.9 4 0 0 4 4 4 3 FYVE-type zinc finger PI3_PI4_kinase PF00454.27 EFX03101.1 - 0.19 11.5 0.1 0.27 11.0 0.1 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase DUF737 PF05300.11 EFX03101.1 - 1.3 9.4 5.3 2.3 8.5 5.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF737) HypA PF01155.19 EFX03101.1 - 7.6 6.6 29.1 0.38 10.8 1.3 3.4 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA EF-hand_4 PF12763.7 EFX03102.1 - 5.3e-25 87.4 0.0 2.1e-13 50.1 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EFX03102.1 - 8.1e-05 21.9 0.0 0.27 10.9 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFX03102.1 - 0.00012 22.5 0.2 0.56 10.7 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain pair DUF1720 PF08226.11 EFX03102.1 - 0.0013 19.1 50.7 0.0013 19.1 50.7 6.8 5 2 2 7 7 7 3 Domain of unknown function (DUF1720) EF-hand_6 PF13405.6 EFX03102.1 - 0.065 13.2 0.0 44 4.4 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain DUF755 PF05501.11 EFX03102.1 - 2.1 8.7 8.3 13 6.1 8.3 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF4362 PF14275.6 EFX03103.1 - 0.085 13.2 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4362) CAF1C_H4-bd PF12265.8 EFX03104.1 - 5.2e-26 90.7 0.3 4.9e-25 87.6 0.3 2.5 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFX03104.1 - 2.7e-23 81.8 5.8 1e-06 29.4 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX03104.1 - 0.0004 20.6 0.1 0.15 12.4 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3751 PF12571.8 EFX03104.1 - 0.11 12.6 0.1 9.1 6.3 0.0 2.5 2 0 0 2 2 2 0 Phage tail-collar fibre protein DHHC PF01529.20 EFX03105.1 - 5e-35 120.5 9.0 5e-35 120.5 9.0 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase zinc_ribbon_9 PF14369.6 EFX03106.1 - 0.073 13.4 1.8 0.31 11.3 1.2 2.3 2 0 0 2 2 2 0 zinc-ribbon DNA_pol_B PF00136.21 EFX03107.1 - 2.6e-108 362.7 0.2 1.1e-107 360.6 0.1 2.0 2 0 0 2 2 2 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EFX03107.1 - 3.2e-66 222.6 0.6 5.8e-66 221.8 0.6 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EFX03107.1 - 2.9e-36 125.3 0.0 4.5e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EFX03107.1 - 2.2e-23 82.1 9.5 2.2e-23 82.1 9.5 2.4 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EFX03107.1 - 0.035 13.0 0.0 0.073 11.9 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral 2OG-FeII_Oxy_2 PF13532.6 EFX03108.1 - 2.9e-27 96.2 0.0 4.3e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EFX03108.1 - 9.6e-24 84.5 0.0 3e-23 82.9 0.0 1.8 1 1 0 1 1 1 1 Isochorismatase family GST_C_2 PF13410.6 EFX03108.1 - 0.0034 17.4 0.0 0.0083 16.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain FAD_binding_6 PF00970.24 EFX03109.1 - 5.9e-31 106.8 0.0 8.8e-31 106.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFX03109.1 - 6.4e-29 100.8 0.0 9.1e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFX03109.1 - 0.00045 20.4 0.0 0.017 15.3 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain RNase_PH PF01138.21 EFX03110.1 - 7.9e-13 49.1 0.0 1.4e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFX03110.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 NAD_binding_2 PF03446.15 EFX03112.1 - 8.5e-27 94.3 1.0 1.4e-26 93.6 1.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFX03112.1 - 7e-07 29.5 0.8 2.5e-06 27.7 0.8 1.9 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EFX03112.1 - 0.00096 19.2 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EFX03112.1 - 0.0019 18.7 0.1 0.008 16.7 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DNA_ligase_A_M PF01068.21 EFX03113.1 - 3.1e-42 144.5 0.0 4.9e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFX03113.1 - 2.7e-38 132.0 0.0 5.6e-38 131.0 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 EFX03113.1 - 1.6e-17 64.3 0.0 2.7e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 RNA ligase BRCT_2 PF16589.5 EFX03113.1 - 1e-16 61.1 0.0 2.1e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 EFX03113.1 - 4.7e-15 56.0 0.0 1.2e-14 54.7 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EFX03113.1 - 2.2e-05 24.7 0.0 0.001 19.4 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.19 EFX03113.1 - 0.042 13.7 0.0 0.47 10.3 0.0 2.2 1 1 1 2 2 2 0 mRNA capping enzyme, catalytic domain DNA_ligase_IV PF11411.8 EFX03113.1 - 0.11 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 DNA ligase IV Utp14 PF04615.13 EFX03114.1 - 1e-172 576.6 86.9 1e-172 576.6 86.9 2.0 1 1 1 2 2 2 1 Utp14 protein TRP PF06011.12 EFX03115.1 - 3.7e-75 253.3 25.4 4.8e-74 249.6 21.7 3.4 1 1 1 2 2 2 1 Transient receptor potential (TRP) ion channel Dioxygenase_C PF00775.21 EFX03115.1 - 7.9e-43 146.0 0.0 1.6e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EFX03115.1 - 1.6e-30 104.7 0.0 3.1e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 Catechol dioxygenase N terminus TRP_N PF14558.6 EFX03115.1 - 6e-21 75.3 0.3 1.7e-09 38.2 0.1 2.3 1 1 1 2 2 2 2 ML-like domain CarboxypepD_reg PF13620.6 EFX03115.1 - 0.0076 16.5 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain C2 PF00168.30 EFX03116.1 - 0.0006 20.1 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain Mis12 PF05859.12 EFX03117.1 - 9e-48 161.8 0.0 1.7e-47 160.9 0.0 1.5 1 0 0 1 1 1 1 Mis12 protein Myb_DNA-bind_6 PF13921.6 EFX03118.1 - 9.9e-05 22.5 0.0 0.00016 21.8 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rap1_C PF11626.8 EFX03118.1 - 0.0027 17.7 0.1 0.0049 16.9 0.1 1.4 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.31 EFX03118.1 - 0.24 11.6 0.3 0.24 11.6 0.3 1.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain 2_5_RNA_ligase2 PF13563.6 EFX03119.1 - 2.4e-21 76.2 0.0 3e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Dynamin_N PF00350.23 EFX03120.1 - 2.5e-16 60.2 0.8 4.5e-16 59.4 0.0 1.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFX03120.1 - 3.6e-09 36.7 0.0 2.4e-08 34.0 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX03120.1 - 3.9e-07 29.8 0.5 6.4e-06 25.8 0.9 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IIGP PF05049.13 EFX03120.1 - 0.068 12.2 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) TsaE PF02367.17 EFX03120.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ERG2_Sigma1R PF04622.12 EFX03121.1 - 9e-93 309.4 0.2 1.1e-92 309.1 0.2 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein UCR_6-4kD PF08997.10 EFX03121.1 - 0.11 12.4 1.4 1.9 8.5 0.2 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein La PF05383.17 EFX03122.1 - 5.7e-19 67.9 0.0 9.1e-19 67.3 0.0 1.3 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFX03122.1 - 1.5e-06 27.9 0.1 3.5e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sel1 PF08238.12 EFX03123.1 - 2e-39 133.1 29.8 8.3e-07 29.5 0.1 7.4 7 0 0 7 7 7 7 Sel1 repeat Patatin PF01734.22 EFX03124.1 - 2.6e-13 50.6 0.0 8.1e-13 49.0 0.0 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase DUF4767 PF15983.5 EFX03124.1 - 0.2 11.9 0.4 1.4 9.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4767) Polysacc_syn_2C PF08485.10 EFX03124.1 - 0.21 11.3 0.6 0.57 9.9 0.2 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein C-terminal TPR_1 PF00515.28 EFX03125.1 - 9.1e-31 104.4 18.2 1.1e-06 28.2 0.1 8.7 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 EFX03125.1 - 3.1e-30 101.8 23.7 4e-05 23.4 0.2 10.1 10 0 0 10 10 10 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX03125.1 - 1.1e-26 92.8 14.8 1.4e-18 66.9 0.0 4.7 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFX03125.1 - 2.5e-21 74.0 12.9 0.019 15.1 0.0 9.2 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFX03125.1 - 3.3e-19 67.9 28.2 0.0068 17.1 0.0 10.8 5 2 6 11 11 11 6 Tetratricopeptide repeat TPR_19 PF14559.6 EFX03125.1 - 1.2e-16 61.0 17.5 0.0003 21.2 0.4 6.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFX03125.1 - 6.7e-15 54.5 11.3 4.8e-06 26.2 2.4 6.1 3 2 3 6 6 6 4 TPR repeat TPR_7 PF13176.6 EFX03125.1 - 7.9e-13 47.5 16.7 0.0054 16.7 0.0 8.4 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFX03125.1 - 1.3e-12 47.2 11.0 0.38 11.2 0.3 8.1 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFX03125.1 - 2.4e-12 47.0 25.4 0.31 11.3 0.1 8.2 6 3 0 7 7 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFX03125.1 - 9.7e-12 45.3 30.4 2.3e-06 28.1 1.8 7.0 4 2 1 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFX03125.1 - 1.4e-09 37.9 14.1 0.22 12.3 0.0 8.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFX03125.1 - 9.8e-07 28.8 13.5 0.31 11.2 2.7 6.2 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 EFX03125.1 - 0.0045 16.3 16.6 0.034 13.4 6.6 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat SUIM_assoc PF16619.5 EFX03125.1 - 1.1 9.4 5.9 24 5.1 2.8 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TYW3 PF02676.14 EFX03126.1 - 2.3e-68 229.7 0.0 3e-68 229.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 Glyco_hydro_28 PF00295.17 EFX03127.1 - 2.9e-89 299.3 20.8 1.5e-87 293.8 20.8 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 PAN_4 PF14295.6 EFX03127.1 - 0.15 12.0 1.5 0.56 10.2 1.5 2.1 1 1 0 1 1 1 0 PAN domain adh_short_C2 PF13561.6 EFX03128.1 - 2.2e-48 164.9 3.8 6.3e-48 163.4 4.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX03128.1 - 4.2e-41 140.6 2.6 8.7e-41 139.5 2.6 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Lactamase_B PF00753.27 EFX03128.1 - 3.7e-17 63.0 9.7 1.5e-15 57.7 7.3 3.1 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily KR PF08659.10 EFX03128.1 - 5.6e-12 45.9 0.1 1.1e-11 45.0 0.1 1.4 1 0 0 1 1 1 1 KR domain Lactamase_B_2 PF12706.7 EFX03128.1 - 8.6e-06 25.4 1.6 1.7e-05 24.4 1.6 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFX03128.1 - 0.0042 17.0 0.2 0.0082 16.1 0.2 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EFX03128.1 - 0.013 15.0 0.0 0.098 12.1 0.0 2.2 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain YjeF_N PF03853.15 EFX03128.1 - 0.032 14.1 0.0 0.31 10.9 0.1 2.3 2 0 0 2 2 2 0 YjeF-related protein N-terminus Actin PF00022.19 EFX03129.1 - 3.9e-15 55.4 0.0 3.8e-11 42.2 0.0 2.4 2 0 0 2 2 2 2 Actin LAP1C PF05609.12 EFX03129.1 - 2.4 7.2 8.2 3.8 6.5 8.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nop14 PF04147.12 EFX03129.1 - 4.7 5.3 23.2 6.8 4.8 23.2 1.1 1 0 0 1 1 1 0 Nop14-like family bZIP_1 PF00170.21 EFX03131.1 - 8e-05 22.7 4.9 0.00012 22.2 4.9 1.2 1 0 0 1 1 1 1 bZIP transcription factor Circo_capsid PF02443.15 EFX03131.1 - 0.0071 16.0 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Circovirus capsid protein bZIP_2 PF07716.15 EFX03131.1 - 0.11 12.6 6.9 0.16 12.1 6.9 1.2 1 0 0 1 1 1 0 Basic region leucine zipper Ribosomal_60s PF00428.19 EFX03131.1 - 2.8 8.6 9.2 0.14 12.8 0.9 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein EIF_2_alpha PF07541.12 EFX03132.1 - 4.2e-36 123.6 0.0 8.9e-36 122.5 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EFX03132.1 - 3.9e-13 49.5 0.2 7.2e-13 48.7 0.2 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Hemagglutinin PF00509.18 EFX03132.1 - 0.087 11.2 0.2 0.12 10.7 0.2 1.2 1 0 0 1 1 1 0 Haemagglutinin Spindle_Spc25 PF08234.12 EFX03132.1 - 0.15 12.3 0.2 0.36 11.1 0.0 1.7 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 Zn_clus PF00172.18 EFX03133.1 - 4.1e-08 33.2 11.9 6.6e-08 32.5 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Presenilin PF01080.17 EFX03133.1 - 0.0019 17.0 7.6 0.0019 17.0 7.6 3.0 3 0 0 3 3 3 1 Presenilin Pinin_SDK_memA PF04696.13 EFX03133.1 - 0.013 15.6 21.9 0.013 15.6 21.9 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region LMBR1 PF04791.16 EFX03133.1 - 0.15 11.0 2.7 0.21 10.4 2.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ECH_2 PF16113.5 EFX03133.1 - 0.26 10.8 14.8 0.17 11.3 7.1 2.2 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase PA26 PF04636.13 EFX03133.1 - 0.49 9.3 13.3 1.2 8.0 9.1 2.3 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) RIFIN PF02009.16 EFX03133.1 - 0.58 10.0 11.9 6.9 6.5 7.6 2.3 2 0 0 2 2 2 0 Rifin MCU PF04678.13 EFX03133.1 - 0.92 9.6 11.6 2.1 8.4 6.9 2.5 2 0 0 2 2 2 0 Mitochondrial calcium uniporter RR_TM4-6 PF06459.12 EFX03133.1 - 3.1 7.6 27.9 0.014 15.2 11.9 2.9 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 PTPRCAP PF15713.5 EFX03133.1 - 3.3 8.0 22.6 3.4 7.9 0.7 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated VIT1 PF01988.19 EFX03133.1 - 3.9 7.3 12.3 1.3 8.8 6.7 2.2 2 0 0 2 2 2 0 VIT family DUF4050 PF13259.6 EFX03133.1 - 5.1 7.4 27.7 0.48 10.7 10.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) DUF4366 PF14283.6 EFX03133.1 - 5.1 7.1 16.1 0.91 9.6 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) AAA_23 PF13476.6 EFX03133.1 - 6.6 7.2 19.5 3.1 8.3 12.7 2.2 2 0 0 2 2 2 0 AAA domain SpoIIP PF07454.11 EFX03133.1 - 7.4 5.9 17.1 24 4.3 13.9 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) GAGA_bind PF06217.12 EFX03133.1 - 7.6 6.7 21.7 0.078 13.2 9.0 2.8 3 0 0 3 3 3 0 GAGA binding protein-like family EOS1 PF12326.8 EFX03134.1 - 1.4e-05 25.1 4.4 1.7e-05 24.8 1.9 2.1 1 1 1 2 2 2 1 N-glycosylation protein Ribosomal_L22 PF00237.19 EFX03135.1 - 6e-19 68.2 0.0 1.2e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e HAD_2 PF13419.6 EFX03137.1 - 1.4e-12 48.0 0.0 1.9e-06 28.1 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFX03137.1 - 6e-11 43.0 0.7 0.0019 18.5 0.0 3.2 1 1 2 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX03137.1 - 2.3e-07 30.8 1.2 5.6e-07 29.5 1.2 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EFX03137.1 - 9.2e-05 22.9 0.8 0.0019 18.7 0.8 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 EFX03137.1 - 0.015 14.9 0.0 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase BSD PF03909.17 EFX03140.1 - 8.3e-17 61.0 0.0 1.7e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 BSD domain Nop14 PF04147.12 EFX03140.1 - 0.012 13.9 37.6 0.016 13.4 37.6 1.3 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EFX03140.1 - 0.17 9.9 36.8 0.34 9.0 36.8 1.5 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_r2 PF04542.14 EFX03140.1 - 0.23 11.2 1.2 0.34 10.7 0.1 1.8 2 0 0 2 2 2 0 Sigma-70 region 2 Lin-8 PF03353.15 EFX03140.1 - 2 7.9 18.7 3.2 7.2 18.7 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DDHD PF02862.17 EFX03140.1 - 2.7 8.1 13.7 11 6.1 12.6 2.4 2 1 0 2 2 2 0 DDHD domain PI3K_1B_p101 PF10486.9 EFX03140.1 - 2.8 5.6 14.8 4.1 5.0 14.8 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MCM_bind PF09739.9 EFX03140.1 - 6.1 5.2 13.7 8.6 4.7 13.7 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SID-1_RNA_chan PF13965.6 EFX03140.1 - 6.4 5.1 4.2 8.2 4.7 4.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TRAP_alpha PF03896.16 EFX03140.1 - 6.8 5.8 19.3 15 4.7 19.3 1.7 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FA_hydroxylase PF04116.13 EFX03141.1 - 6e-27 94.6 15.1 6e-27 94.6 15.1 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily SBDS PF01172.18 EFX03142.1 - 1.6e-23 82.6 0.2 2.3e-23 82.1 0.0 1.3 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein OB_Dis3 PF17849.1 EFX03142.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Dis3-like cold-shock domain 2 (CSD2) IIGP PF05049.13 EFX03143.1 - 2.9e-23 82.6 0.0 3.6e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 EFX03143.1 - 5.4e-07 29.7 0.0 9e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFX03143.1 - 0.00029 21.4 0.1 0.00098 19.7 0.1 1.7 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EFX03143.1 - 0.00086 19.3 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EFX03143.1 - 0.0013 18.3 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.6 EFX03143.1 - 0.0018 18.5 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 EFX03143.1 - 0.0021 17.4 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EFX03143.1 - 0.0032 17.6 0.5 0.0032 17.6 0.5 2.1 2 1 0 2 2 1 1 Dynamin family AAA_16 PF13191.6 EFX03143.1 - 0.01 16.2 0.1 0.033 14.6 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 EFX03143.1 - 0.016 15.0 0.0 0.025 14.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFX03143.1 - 0.02 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EFX03143.1 - 0.035 13.6 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFX03143.1 - 0.036 13.8 2.3 0.12 12.1 0.2 2.2 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EFX03143.1 - 0.052 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFX03143.1 - 0.053 14.1 2.7 0.13 12.9 0.1 2.5 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 EFX03143.1 - 0.056 13.7 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFX03143.1 - 0.1 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_7 PF12775.7 EFX03143.1 - 0.12 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EFX03143.1 - 0.13 12.8 4.8 0.74 10.3 4.4 2.2 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFX03143.1 - 0.15 11.8 0.2 0.6 9.8 0.1 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 EFX03143.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Glyco_hydro_47 PF01532.20 EFX03144.1 - 3.9e-135 451.3 0.0 4.5e-135 451.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 NACHT PF05729.12 EFX03145.1 - 4.6e-08 33.2 0.0 1.8e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EFX03145.1 - 0.00099 19.5 0.0 0.0028 18.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain dNK PF01712.19 EFX03145.1 - 0.0086 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Deoxynucleoside kinase RsgA_GTPase PF03193.16 EFX03145.1 - 0.023 14.6 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EFX03145.1 - 0.023 14.4 0.2 0.048 13.4 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EFX03145.1 - 0.056 14.0 0.0 0.27 11.8 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 EFX03145.1 - 0.066 13.7 0.6 0.066 13.7 0.6 2.2 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 EFX03145.1 - 0.074 13.3 0.0 0.59 10.4 0.0 2.4 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFX03145.1 - 0.12 12.9 0.1 0.39 11.2 0.1 1.8 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 EFX03145.1 - 0.13 12.1 0.0 0.46 10.2 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 EFX03147.1 - 0.0046 16.7 0.0 0.0072 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain DUF3987 PF13148.6 EFX03147.1 - 0.01 14.9 0.1 0.05 12.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_16 PF13191.6 EFX03147.1 - 0.02 15.3 1.9 0.097 13.0 0.4 2.6 1 1 1 2 2 2 0 AAA ATPase domain AAA PF00004.29 EFX03147.1 - 0.048 14.1 0.3 0.17 12.3 0.3 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNAP PF14938.6 EFX03147.1 - 0.078 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP AAA_22 PF13401.6 EFX03147.1 - 0.093 13.0 0.2 0.29 11.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain Hexapep_loop PF18776.1 EFX03147.1 - 0.13 11.9 0.2 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Hexapeptide repeat including loop MARVEL PF01284.23 EFX03148.1 - 1.8e-17 63.7 13.1 2.1e-17 63.5 13.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain RNA_Me_trans PF04252.13 EFX03149.1 - 2.3e-80 268.9 0.0 2.6e-80 268.7 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase WD40 PF00400.32 EFX03150.1 - 2.7e-05 24.8 2.1 0.00016 22.4 0.0 3.5 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF2415 PF10313.9 EFX03150.1 - 0.061 13.3 0.0 0.34 10.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) TFIIA PF03153.13 EFX03150.1 - 1.2 9.1 7.3 1.6 8.6 7.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NAT PF04768.13 EFX03151.1 - 9.5e-49 165.3 0.0 7e-48 162.5 0.0 2.0 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase RPE65 PF03055.15 EFX03152.1 - 1.1e-109 367.7 0.0 1.5e-109 367.3 0.0 1.1 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein ArfGap PF01412.18 EFX03153.1 - 2.7e-31 108.1 0.1 4.3e-31 107.4 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf p450 PF00067.22 EFX03155.1 - 6.3e-25 87.8 0.0 1.4e-24 86.7 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 Pkinase PF00069.25 EFX03156.1 - 5.8e-54 183.2 0.0 2.8e-49 167.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03156.1 - 3.6e-34 118.2 0.0 3.2e-33 115.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX03156.1 - 3.5e-08 33.1 0.0 7.9e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFX03156.1 - 0.004 16.0 0.0 0.0066 15.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFX03156.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFX03156.1 - 0.079 11.9 0.1 0.12 11.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PAZ PF02170.22 EFX03156.1 - 0.16 11.8 0.0 0.44 10.3 0.0 1.7 2 0 0 2 2 2 0 PAZ domain FAA_hydrolase PF01557.18 EFX03158.1 - 2.4e-51 174.5 0.0 3e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Dirigent PF03018.14 EFX03158.1 - 0.044 13.6 0.2 0.15 11.9 0.1 1.8 2 0 0 2 2 2 0 Dirigent-like protein ZU5 PF00791.20 EFX03158.1 - 0.055 13.8 0.0 0.13 12.6 0.0 1.6 2 0 0 2 2 2 0 ZU5 domain SF3b1 PF08920.10 EFX03159.1 - 1.4e-26 93.3 3.7 1.4e-26 93.3 3.7 2.1 2 1 0 2 2 1 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EFX03159.1 - 2.5e-11 43.8 6.4 0.1 13.0 0.1 8.2 6 2 4 10 10 10 3 HEAT repeats HEAT_EZ PF13513.6 EFX03159.1 - 3e-11 43.6 6.1 0.016 15.7 0.0 7.2 8 0 0 8 8 7 3 HEAT-like repeat HEAT PF02985.22 EFX03159.1 - 5.8e-10 38.6 12.0 0.068 13.5 0.2 9.7 11 0 0 11 11 11 3 HEAT repeat Cnd1 PF12717.7 EFX03159.1 - 1.8e-07 31.3 1.7 0.12 12.4 0.0 6.2 5 2 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFX03159.1 - 2.1e-07 31.5 0.7 0.48 11.1 0.0 5.3 6 0 0 6 6 6 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EFX03159.1 - 4.6e-05 23.4 3.1 0.086 12.7 0.1 5.1 5 1 0 5 5 5 1 Domain of unknown function (DUF3385) NUC173 PF08161.12 EFX03159.1 - 0.00022 21.0 0.4 0.95 9.1 0.0 4.2 4 2 0 5 5 5 2 NUC173 domain Adaptin_N PF01602.20 EFX03159.1 - 0.00055 18.6 0.9 0.17 10.4 0.0 3.3 2 2 0 3 3 3 2 Adaptin N terminal region UNC45-central PF11701.8 EFX03159.1 - 0.00085 19.3 0.0 0.0029 17.6 0.0 1.9 2 0 0 2 2 1 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EFX03159.1 - 0.0014 18.2 0.1 1.8 8.0 0.0 3.7 4 0 0 4 4 4 1 CLASP N terminal DRIM PF07539.12 EFX03159.1 - 0.028 12.7 0.3 5.7 5.1 0.0 3.8 2 1 2 4 4 3 0 Down-regulated in metastasis MMS19_C PF12460.8 EFX03159.1 - 0.1 11.7 0.0 4.9 6.2 0.0 3.2 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal 14-3-3 PF00244.20 EFX03160.1 - 2.6e-107 357.4 1.8 3.6e-107 356.9 1.8 1.2 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 EFX03160.1 - 0.0036 15.7 0.8 0.006 15.0 0.8 1.3 1 0 0 1 1 1 1 Orbivirus outer capsid protein VP5 DUF327 PF03885.13 EFX03160.1 - 0.14 12.1 0.6 1.1 9.3 0.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF327) Ima1_N PF09779.9 EFX03160.1 - 1.7 9.5 3.8 5.4 7.9 0.2 3.0 2 2 0 3 3 3 0 Ima1 N-terminal domain Arteri_Gl PF00951.18 EFX03161.1 - 2.8 7.7 12.7 0.5 10.2 7.2 2.0 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein Spo7 PF03907.13 EFX03162.1 - 1.1e-93 312.8 0.0 1.8e-93 312.1 0.0 1.3 1 0 0 1 1 1 1 Spo7-like protein HABP4_PAI-RBP1 PF04774.15 EFX03163.1 - 0.0018 19.1 1.1 0.0025 18.7 1.1 1.2 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family ELMO_CED12 PF04727.13 EFX03164.1 - 2.4e-49 167.8 0.0 4.7e-49 166.9 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EFX03164.1 - 1.3e-31 109.9 0.0 7.3e-30 104.2 0.0 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 EFX03164.1 - 1.1e-11 44.9 0.0 6.3e-11 42.4 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3361) CHASE PF03924.13 EFX03164.1 - 0.062 13.2 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 CHASE domain Pkinase PF00069.25 EFX03165.1 - 4.8e-09 36.0 0.0 2.7e-06 27.0 0.0 3.0 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03165.1 - 4.8e-07 29.3 0.0 4.3e-05 22.9 0.0 3.2 2 1 0 2 2 2 1 Protein tyrosine kinase KH_1 PF00013.29 EFX03166.1 - 1.9e-26 91.7 4.6 9.6e-07 28.5 0.0 6.3 6 0 0 6 6 6 5 KH domain DUF1479 PF07350.12 EFX03166.1 - 0.012 14.4 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) Ribosomal_L36e PF01158.18 EFX03167.1 - 3e-42 142.8 4.2 3.4e-42 142.6 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.9 EFX03167.1 - 0.019 15.1 0.3 0.022 14.9 0.3 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 PBS_linker_poly PF00427.21 EFX03167.1 - 0.084 12.9 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide eIF-1a PF01176.19 EFX03168.1 - 6.7e-18 64.3 0.0 9.4e-18 63.8 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RNA_pol_Rpb5_C PF01191.19 EFX03169.1 - 1.6e-33 114.4 0.1 2.7e-33 113.6 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EFX03169.1 - 1.7e-27 95.8 0.0 2.6e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EFX03169.1 - 0.0027 17.7 0.0 0.011 15.8 0.0 1.9 2 0 0 2 2 2 1 Restriction endonuclease Mrr_cat_2 PF13156.6 EFX03169.1 - 0.13 12.2 0.1 0.33 10.8 0.0 1.6 1 1 0 1 1 1 0 Restriction endonuclease ATP-synt_C PF00137.21 EFX03170.1 - 4e-24 84.7 34.5 8.6e-15 54.8 11.2 3.0 3 0 0 3 3 3 2 ATP synthase subunit C SLATT_5 PF18160.1 EFX03170.1 - 0.094 12.0 1.7 0.19 11.1 0.0 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF3671 PF12420.8 EFX03170.1 - 1 9.5 3.2 0.7 10.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function RRM_1 PF00076.22 EFX03171.1 - 2e-30 104.4 0.1 4.2e-14 52.1 0.0 3.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFX03171.1 - 7.5e-05 22.8 0.0 0.079 13.1 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 EFX03171.1 - 0.00023 20.8 0.0 0.55 9.8 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EFX03171.1 - 0.02 15.1 0.0 8.7 6.5 0.0 3.2 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DbpA PF03880.15 EFX03171.1 - 0.046 13.7 0.1 12 6.0 0.0 3.2 3 0 0 3 3 3 0 DbpA RNA binding domain DUF4783 PF16022.5 EFX03171.1 - 0.076 13.2 0.0 0.91 9.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) Limkain-b1 PF11608.8 EFX03171.1 - 0.15 12.1 0.1 34 4.6 0.0 2.9 3 0 0 3 3 3 0 Limkain b1 FXMRP1_C_core PF12235.8 EFX03171.1 - 1.2 9.7 22.8 3.8 8.2 20.1 2.6 2 1 0 2 2 2 0 Fragile X-related 1 protein core C terminal TPT PF03151.16 EFX03172.1 - 1.7e-08 34.1 16.7 5e-08 32.6 16.7 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFX03172.1 - 0.00014 22.1 16.7 0.00014 22.1 16.7 2.4 2 1 0 2 2 2 1 EamA-like transporter family Kelch_5 PF13854.6 EFX03173.1 - 4.6e-12 45.6 6.4 9.4e-11 41.5 0.4 4.9 5 1 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 EFX03173.1 - 0.00016 21.8 0.6 0.00016 21.8 0.6 6.2 7 0 0 7 7 7 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFX03173.1 - 0.00057 19.4 2.7 0.018 14.6 0.3 3.8 3 1 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 EFX03173.1 - 0.00071 19.8 0.7 0.0056 16.9 0.1 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 EFX03173.1 - 0.0093 16.0 0.2 0.0093 16.0 0.2 4.0 5 0 0 5 5 5 1 Galactose oxidase, central domain tRNA-synt_2b PF00587.25 EFX03175.1 - 9.3e-33 113.7 0.0 2.8e-30 105.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFX03175.1 - 3.8e-16 59.0 0.2 7.6e-16 58.0 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EFX03175.1 - 6e-13 48.6 0.0 1.3e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 EFX03175.1 - 2.4e-11 43.6 0.0 5e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Img2 PF05046.14 EFX03175.1 - 0.19 12.1 0.1 3.8 7.9 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) zf-RanBP PF00641.18 EFX03176.1 - 4.7e-18 64.2 14.2 8.6e-11 41.0 1.6 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EFX03176.1 - 3e-08 33.4 0.0 6.2e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EFX03176.1 - 8.1e-06 26.5 0.0 1.2e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Ras PF00071.22 EFX03177.1 - 9.5e-31 106.6 1.8 3.3e-20 72.3 0.1 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFX03177.1 - 8.1e-16 58.3 1.2 1.3e-08 35.1 0.1 2.6 1 1 2 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX03177.1 - 0.0023 17.4 0.7 0.047 13.1 0.1 2.1 1 1 0 2 2 2 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EFX03177.1 - 0.0025 18.2 0.1 0.0059 17.0 0.1 1.7 1 1 0 1 1 1 1 RNA helicase G-alpha PF00503.20 EFX03177.1 - 0.0067 15.6 0.3 0.47 9.5 0.0 2.1 2 0 0 2 2 2 1 G-protein alpha subunit AAA_7 PF12775.7 EFX03177.1 - 0.02 14.4 0.1 0.034 13.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EFX03177.1 - 0.02 14.8 0.9 4 7.3 0.1 2.2 1 1 0 2 2 2 0 RsgA GTPase Pox_A32 PF04665.12 EFX03177.1 - 0.023 14.1 1.1 0.034 13.6 0.3 1.5 1 1 1 2 2 2 0 Poxvirus A32 protein AAA_16 PF13191.6 EFX03177.1 - 0.042 14.2 0.0 0.045 14.1 0.0 1.2 1 1 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EFX03177.1 - 0.056 13.4 0.1 0.13 12.2 0.1 1.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EFX03177.1 - 0.071 12.8 0.4 0.12 12.1 0.3 1.4 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFX03177.1 - 0.078 13.1 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EFX03177.1 - 0.17 11.1 0.7 0.23 10.7 0.1 1.5 2 0 0 2 2 2 0 Septin MFS_1 PF07690.16 EFX03178.1 - 2.2e-27 95.9 43.2 3e-25 88.9 21.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03178.1 - 5.5e-13 48.6 10.5 5.5e-13 48.6 10.5 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter ATP11 PF06644.11 EFX03179.1 - 2.2e-96 322.8 0.0 2.6e-96 322.6 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein SR-25 PF10500.9 EFX03179.1 - 0.13 11.9 9.1 0.2 11.2 9.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sporozoite_P67 PF05642.11 EFX03179.1 - 1.7 6.6 7.0 2.2 6.2 7.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen WD40 PF00400.32 EFX03180.1 - 4.3e-24 84.3 1.1 2.9e-06 27.9 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat Peptidase_S49_N PF08496.10 EFX03180.1 - 0.025 14.7 0.2 0.025 14.7 0.2 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal ANAPC4_WD40 PF12894.7 EFX03180.1 - 0.067 13.5 0.0 2.3 8.6 0.0 3.0 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFX03180.1 - 0.12 11.7 0.0 0.45 9.8 0.0 1.8 2 0 0 2 2 2 0 WD40-like domain PQQ_3 PF13570.6 EFX03180.1 - 0.55 10.8 3.4 9 6.9 0.6 3.6 3 0 0 3 3 3 0 PQQ-like domain Topoisom_I PF01028.20 EFX03181.1 - 8.9e-96 319.6 4.8 1.9e-95 318.5 4.8 1.6 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EFX03181.1 - 9.4e-94 312.9 1.7 9.4e-94 312.9 1.7 2.0 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EFX03181.1 - 2.9e-31 107.2 0.2 9.1e-31 105.6 0.2 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain VTC PF09359.10 EFX03181.1 - 0.069 12.5 7.1 0.53 9.6 0.0 2.6 2 0 0 2 2 2 0 VTC domain DnaJ_C PF01556.18 EFX03182.1 - 6.2e-35 120.5 0.1 8.9e-35 120.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EFX03182.1 - 1.1e-14 54.5 15.8 1.9e-14 53.7 15.8 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 EFX03182.1 - 1.1e-11 44.7 0.7 2.6e-11 43.5 0.7 1.6 1 0 0 1 1 1 1 DnaJ domain HypA PF01155.19 EFX03182.1 - 0.076 13.0 8.2 1.1 9.3 1.3 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EFX03182.1 - 0.21 11.6 15.0 1.4 9.0 2.5 2.7 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF1356 PF07092.12 EFX03182.1 - 0.76 9.0 2.5 2.4 7.4 0.4 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1356) Cytochrome_C7 PF14522.6 EFX03182.1 - 1.1 9.3 8.3 1.1 9.3 1.8 2.3 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c TackOD1 PF18551.1 EFX03182.1 - 1.6 8.4 7.9 2.6 7.7 0.8 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-RING_10 PF16685.5 EFX03182.1 - 2.5 8.3 8.3 2.9 8.1 0.9 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 DZR PF12773.7 EFX03182.1 - 3.6 7.7 9.4 13 5.9 1.6 2.5 2 0 0 2 2 2 0 Double zinc ribbon Ras PF00071.22 EFX03183.1 - 1.6e-40 138.4 0.0 2.5e-38 131.2 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFX03183.1 - 8.5e-32 109.9 0.0 1.2e-31 109.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX03183.1 - 1.2e-09 37.9 0.0 1.9e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX03183.1 - 6.1e-05 23.1 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFX03183.1 - 0.0025 17.3 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EFX03183.1 - 0.0037 17.7 0.0 0.0064 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFX03183.1 - 0.057 13.1 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFX03183.1 - 0.099 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain DLIC PF05783.11 EFX03183.1 - 0.11 11.3 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) PduV-EutP PF10662.9 EFX03183.1 - 0.15 11.8 0.0 3.1 7.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EFX03183.1 - 0.21 11.1 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 EFX03183.1 - 0.23 10.7 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Septin SF3b10 PF07189.11 EFX03184.1 - 1e-30 105.6 0.0 1.2e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) TAP_C PF03943.13 EFX03185.1 - 2.1e-15 56.1 0.3 4.5e-15 55.0 0.3 1.6 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.20 EFX03185.1 - 6.1e-08 33.3 0.0 1.4e-07 32.1 0.0 1.6 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_9 PF18444.1 EFX03185.1 - 4e-06 26.6 0.0 1.1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif LRR_4 PF12799.7 EFX03185.1 - 1.9e-05 24.9 5.7 0.0022 18.4 0.3 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFX03185.1 - 0.0095 15.7 0.4 0.025 14.3 0.4 1.8 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.6 EFX03185.1 - 0.0095 15.5 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat UBA_4 PF14555.6 EFX03185.1 - 0.039 13.8 0.7 0.08 12.8 0.1 1.9 2 0 0 2 2 2 0 UBA-like domain LRR_1 PF00560.33 EFX03185.1 - 0.13 12.9 0.1 5.6 7.9 0.1 2.9 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 EFX03185.1 - 0.2 11.8 0.2 4.4 7.6 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich repeat Med1 PF10744.9 EFX03186.1 - 4.1e-113 378.6 0.0 5.1e-113 378.2 0.0 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 YEATS PF03366.16 EFX03187.1 - 5.2e-22 77.6 0.1 1.1e-21 76.6 0.1 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EFX03187.1 - 0.00081 19.5 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Baculo_8kDa PF06096.11 EFX03187.1 - 0.13 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein ATG2_CAD PF13329.6 EFX03188.1 - 1.2e-48 164.8 0.1 3e-48 163.5 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EFX03188.1 - 4.2e-33 113.6 0.2 3.3e-32 110.7 0.1 2.7 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 EFX03188.1 - 9.3e-07 29.0 0.0 2.3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 EFX03188.1 - 0.053 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Sec62 PF03839.16 EFX03189.1 - 1.7e-71 240.2 0.1 2.4e-71 239.7 0.1 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 Ran_BP1 PF00638.18 EFX03190.1 - 2e-49 166.9 0.5 2e-49 166.9 0.5 1.5 2 0 0 2 2 2 1 RanBP1 domain PS-DH PF14765.6 EFX03190.1 - 0.0021 17.4 0.6 0.0039 16.5 0.3 1.5 2 0 0 2 2 2 1 Polyketide synthase dehydratase WH1 PF00568.23 EFX03190.1 - 0.05 13.5 0.0 0.16 11.9 0.0 1.8 1 1 0 1 1 1 0 WH1 domain CDC27 PF09507.10 EFX03190.1 - 4.2 6.7 18.4 0.13 11.6 9.9 2.0 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Amino_oxidase PF01593.24 EFX03191.1 - 3.8e-19 69.3 0.0 4.8e-19 69.0 0.0 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFX03191.1 - 7.1e-16 58.2 0.1 1.2e-15 57.5 0.1 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX03191.1 - 9.6e-06 25.0 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX03191.1 - 0.00026 21.5 0.1 0.00047 20.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX03191.1 - 0.0011 18.2 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX03191.1 - 0.002 17.8 1.2 0.0029 17.3 1.1 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFX03191.1 - 0.0024 16.7 0.0 0.0033 16.2 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EFX03191.1 - 0.0027 17.0 0.4 0.0039 16.5 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFX03191.1 - 0.0074 15.6 0.0 0.021 14.1 0.0 1.6 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 EFX03191.1 - 0.017 14.4 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EFX03191.1 - 0.027 14.3 0.1 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EFX03191.1 - 0.029 14.4 0.1 0.042 13.8 0.1 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 EFX03191.1 - 0.07 12.5 0.1 0.074 12.4 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EFX03191.1 - 0.21 10.6 0.1 0.3 10.1 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FUSC_2 PF13515.6 EFX03192.1 - 1.8e-25 89.5 5.2 1.8e-25 89.5 5.2 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like SCF PF02404.15 EFX03192.1 - 0.16 11.2 0.2 0.28 10.5 0.2 1.2 1 0 0 1 1 1 0 Stem cell factor FUSC-like PF12805.7 EFX03192.1 - 2 7.4 6.6 5.6 5.9 6.6 1.8 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DHquinase_I PF01487.15 EFX03193.1 - 9.9e-37 127.4 0.0 1.3e-36 127.0 0.0 1.2 1 0 0 1 1 1 1 Type I 3-dehydroquinase SDH_C PF18317.1 EFX03193.1 - 0.13 12.0 0.0 0.42 10.4 0.0 1.9 1 0 0 1 1 1 0 Shikimate 5'-dehydrogenase C-terminal domain Pyridoxal_deC PF00282.19 EFX03194.1 - 1.4e-21 76.7 0.0 2e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain SepSecS PF05889.13 EFX03194.1 - 0.023 13.4 0.0 0.038 12.7 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS 3-HAO PF06052.12 EFX03195.1 - 4.7e-64 214.6 0.0 5.3e-64 214.4 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EFX03195.1 - 8.7e-07 28.6 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EFX03195.1 - 0.00011 21.9 0.0 0.00015 21.4 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.14 EFX03195.1 - 0.00064 19.9 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 ARD/ARD' family AraC_binding PF02311.19 EFX03195.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain DZR PF12773.7 EFX03195.1 - 0.027 14.5 1.1 0.09 12.8 1.1 1.8 1 1 0 1 1 1 0 Double zinc ribbon UPF0547 PF10571.9 EFX03195.1 - 0.066 13.3 0.8 5 7.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 IBR PF01485.21 EFX03195.1 - 0.079 13.2 0.6 0.15 12.3 0.6 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Cupin_4 PF08007.12 EFX03195.1 - 0.1 12.1 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein AdoMet_MTase PF07757.13 EFX03196.1 - 9.3e-36 122.6 0.3 3.3e-35 120.8 0.3 1.8 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 EFX03196.1 - 0.026 14.5 0.0 0.07 13.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFX03196.1 - 0.098 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 EFX03197.1 - 2.9e-29 102.1 31.0 4.1e-29 101.6 31.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sm_multidrug_ex PF06695.11 EFX03197.1 - 0.073 13.7 3.3 8.5 7.0 0.5 2.9 2 0 0 2 2 2 0 Putative small multi-drug export protein YIF1 PF03878.15 EFX03197.1 - 1.8 8.1 9.6 0.089 12.3 3.4 2.0 3 0 0 3 3 3 0 YIF1 DUF3341 PF11821.8 EFX03197.1 - 2.6 7.6 5.1 6.9 6.3 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) CwsA PF10814.8 EFX03199.1 - 0.042 14.0 0.0 0.042 14.0 0.0 2.3 3 0 0 3 3 3 0 Cell wall synthesis protein CwsA Selenoprotein_S PF06936.11 EFX03199.1 - 0.36 10.6 2.3 0.63 9.8 2.3 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) Amidohydro_3 PF07969.11 EFX03200.1 - 3.1e-69 234.7 0.0 5.3e-69 233.9 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family SPX PF03105.19 EFX03200.1 - 5.1e-06 26.7 20.3 3.9e-05 23.7 0.0 3.4 1 1 3 4 4 4 2 SPX domain Amidohydro_1 PF01979.20 EFX03200.1 - 0.00028 20.3 0.0 0.002 17.5 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase family RskA PF10099.9 EFX03200.1 - 0.55 10.5 6.3 2.4 8.4 0.4 3.2 3 0 0 3 3 3 0 Anti-sigma-K factor rskA Zeta_toxin PF06414.12 EFX03201.1 - 4.8e-35 120.7 0.0 9.7e-35 119.7 0.0 1.4 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EFX03201.1 - 2.9e-06 27.5 0.0 4.9e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX03201.1 - 0.00013 22.4 0.4 0.00056 20.3 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 EFX03201.1 - 0.017 15.2 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain SRP54 PF00448.22 EFX03201.1 - 0.027 14.1 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Microtub_bd PF16796.5 EFX03201.1 - 0.036 14.0 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Microtubule binding DUF4449 PF14613.6 EFX03202.1 - 5.1e-64 215.3 0.4 1.5e-63 213.8 0.4 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) PPR_2 PF13041.6 EFX03203.1 - 2e-26 91.9 0.3 1.1e-16 60.8 0.0 3.5 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 EFX03203.1 - 3.3e-08 33.5 1.3 0.0005 20.1 0.0 3.2 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EFX03203.1 - 3.3e-06 26.6 0.2 7.8e-06 25.4 0.2 1.6 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EFX03203.1 - 8.9e-06 25.6 2.8 7.9e-05 22.6 0.1 3.6 4 0 0 4 4 4 1 PPR repeat PPR_1 PF12854.7 EFX03203.1 - 0.00081 19.0 1.9 0.021 14.5 0.0 3.3 3 0 0 3 3 3 1 PPR repeat CUE PF02845.16 EFX03203.1 - 0.0036 17.0 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain RRM_1 PF00076.22 EFX03203.1 - 0.0041 16.9 0.0 0.0085 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G2BR PF18442.1 EFX03203.1 - 0.3 10.8 8.0 0.86 9.3 8.0 1.8 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) Flavin_Reduct PF01613.18 EFX03204.1 - 3.8e-17 62.8 0.0 6.9e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Flavin reductase like domain P5CR_dimer PF14748.6 EFX03205.1 - 4.6e-34 116.8 1.5 4.6e-34 116.8 1.5 2.0 2 0 0 2 2 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EFX03205.1 - 1.4e-08 35.2 7.5 1.1e-07 32.4 0.1 3.5 4 0 0 4 4 3 1 NADP oxidoreductase coenzyme F420-dependent Kelch_6 PF13964.6 EFX03205.1 - 0.00077 19.7 3.3 3.3 8.1 0.0 4.3 4 0 0 4 4 4 2 Kelch motif RIFIN PF02009.16 EFX03205.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Rifin Adeno_E3_CR2 PF02439.15 EFX03205.1 - 0.0016 18.2 0.1 0.023 14.5 0.0 2.4 2 0 0 2 2 2 1 Adenovirus E3 region protein CR2 Glycophorin_A PF01102.18 EFX03205.1 - 0.0036 17.5 0.5 0.0093 16.2 0.5 1.6 1 0 0 1 1 1 1 Glycophorin A MGC-24 PF05283.11 EFX03205.1 - 0.0046 17.4 3.2 0.018 15.5 3.2 2.0 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Amnionless PF14828.6 EFX03205.1 - 0.021 13.7 0.1 0.035 13.0 0.1 1.2 1 0 0 1 1 1 0 Amnionless SKG6 PF08693.10 EFX03205.1 - 0.037 13.5 1.1 0.11 12.0 1.1 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_3 PF13415.6 EFX03205.1 - 0.041 14.2 8.2 0.24 11.7 0.2 4.2 4 0 0 4 4 3 0 Galactose oxidase, central domain Orf78 PF06024.12 EFX03205.1 - 0.045 14.0 0.0 0.095 13.0 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) TMEM154 PF15102.6 EFX03205.1 - 0.07 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family Gram_pos_anchor PF00746.21 EFX03205.1 - 0.072 13.1 0.3 0.46 10.5 0.3 2.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif PTP_tm PF18861.1 EFX03205.1 - 0.1 12.6 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Tox-GHH2 PF15635.6 EFX03205.1 - 0.15 12.6 0.4 0.4 11.2 0.4 1.7 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin 2 Syndecan PF01034.20 EFX03205.1 - 0.22 11.5 0.1 0.48 10.4 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain Kelch_1 PF01344.25 EFX03205.1 - 1.7 8.3 3.6 6.2 6.5 0.1 3.3 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 EFX03206.1 - 2e-43 145.5 27.2 2.7e-08 34.3 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX03206.1 - 7.4e-09 35.8 0.7 0.042 14.2 0.0 4.3 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX03206.1 - 0.00026 19.8 5.1 0.06 12.0 0.1 4.2 3 2 2 5 5 5 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFX03206.1 - 0.0043 16.0 0.1 8.9 5.2 0.0 3.9 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFX03206.1 - 0.0073 15.7 0.0 0.48 9.7 0.0 2.7 2 1 0 3 3 3 1 WD40-like domain PD40 PF07676.12 EFX03206.1 - 0.021 14.8 0.6 22 5.1 0.0 4.3 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat ALAD PF00490.21 EFX03207.1 - 2.4e-121 404.8 0.0 5.1e-121 403.7 0.0 1.5 1 1 1 2 2 2 1 Delta-aminolevulinic acid dehydratase adh_short_C2 PF13561.6 EFX03208.1 - 3.4e-51 174.1 0.1 4.3e-51 173.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX03208.1 - 2.1e-47 161.1 0.1 2.7e-47 160.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX03208.1 - 1.2e-09 38.3 0.0 2.2e-09 37.5 0.0 1.4 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFX03208.1 - 0.013 14.9 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EFX03208.1 - 0.045 13.2 0.0 0.38 10.2 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Pkinase PF00069.25 EFX03209.1 - 4.5e-13 49.2 0.0 1.2e-11 44.5 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03209.1 - 1.1e-12 47.9 0.0 2.5e-11 43.4 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Fis1_TPR_C PF14853.6 EFX03210.1 - 1.3e-25 89.2 1.5 2e-25 88.6 1.5 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EFX03210.1 - 3.8e-17 61.7 0.0 6.8e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EFX03210.1 - 0.00091 19.2 1.6 0.0017 18.3 1.6 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX03210.1 - 0.037 14.7 0.5 0.13 13.0 0.3 2.0 3 0 0 3 3 3 0 Tetratricopeptide repeat GTP_EFTU PF00009.27 EFX03211.1 - 1.2e-54 184.9 0.0 1.7e-54 184.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFX03211.1 - 1.5e-41 141.2 0.0 3.4e-41 140.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFX03211.1 - 7.7e-15 55.1 1.4 7.7e-15 55.1 1.4 2.5 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFX03211.1 - 0.00085 19.4 0.1 0.022 14.9 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EFX03211.1 - 0.019 14.9 0.8 0.061 13.2 0.8 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 4 His_Phos_2 PF00328.22 EFX03212.1 - 1.2e-09 38.0 0.0 4.7e-08 32.8 0.0 2.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MFS_1 PF07690.16 EFX03213.1 - 1.3e-29 103.3 63.5 1.2e-28 100.0 60.4 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03213.1 - 1.3e-07 30.8 15.4 1.3e-07 30.8 15.4 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFX03213.1 - 6.7e-06 24.8 27.0 9.4e-06 24.3 27.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Herpes_US9 PF06072.11 EFX03213.1 - 0.28 11.1 1.1 1 9.3 0.2 2.5 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 OATP PF03137.20 EFX03213.1 - 2.7 6.2 11.7 0.33 9.2 2.7 2.6 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family RhoGAP PF00620.27 EFX03214.1 - 2.8e-38 131.1 0.0 4.3e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF2373 PF10180.9 EFX03215.1 - 1.3e-20 73.0 0.7 2.1e-20 72.3 0.7 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) SQHop_cyclase_C PF13243.6 EFX03216.1 - 1.8e-18 66.7 0.1 1.9e-18 66.7 0.1 1.0 1 0 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 EFX03216.1 - 8.3e-06 25.5 5.2 2.6e-05 23.9 5.2 1.9 1 1 0 1 1 1 1 Prenyltransferase and squalene oxidase repeat ABC2_membrane PF01061.24 EFX03218.1 - 5e-69 231.9 64.7 3.3e-42 144.3 22.0 4.5 4 1 1 5 5 5 3 ABC-2 type transporter ABC_tran PF00005.27 EFX03218.1 - 1.5e-32 113.0 0.1 6.8e-18 65.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EFX03218.1 - 4e-28 97.2 7.5 6.8e-26 90.0 0.5 3.2 4 0 0 4 4 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EFX03218.1 - 1.2e-15 57.8 0.1 3.1e-15 56.6 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EFX03218.1 - 6.2e-07 30.0 0.4 0.0029 18.0 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFX03218.1 - 1.8e-06 28.0 0.3 0.00066 19.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EFX03218.1 - 7.5e-06 25.6 1.0 0.0024 17.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EFX03218.1 - 2.4e-05 24.0 0.4 0.0028 17.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFX03218.1 - 7.5e-05 22.9 0.1 0.0045 17.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX03218.1 - 0.00029 21.1 0.2 0.26 11.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EFX03218.1 - 0.00066 19.6 0.0 0.061 13.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFX03218.1 - 0.0012 19.0 0.1 1.8 8.6 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 EFX03218.1 - 0.003 17.0 0.0 1.7 8.0 0.0 3.1 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EFX03218.1 - 0.0052 17.3 0.0 0.11 13.0 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EFX03218.1 - 0.0084 15.8 0.7 0.85 9.3 0.2 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFX03218.1 - 0.012 15.5 1.6 1.3 8.9 0.1 2.7 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 EFX03218.1 - 0.028 14.2 0.7 1.1 9.0 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_23 PF13476.6 EFX03218.1 - 0.031 14.8 1.1 0.12 12.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 EFX03218.1 - 0.032 13.3 49.2 0.095 11.8 22.4 3.9 2 2 0 2 2 2 0 ABC-2 family transporter protein AAA_17 PF13207.6 EFX03218.1 - 0.062 13.7 1.3 1.8 9.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain Ploopntkinase3 PF18751.1 EFX03218.1 - 0.11 12.4 0.3 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA PF00004.29 EFX03218.1 - 0.12 12.8 0.1 1.5 9.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EFX03218.1 - 0.12 11.9 4.3 0.82 9.2 0.4 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EFX03218.1 - 0.13 12.5 1.5 0.15 12.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.18 EFX03218.1 - 0.16 11.6 0.2 6.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ELP6 PF09807.9 EFX03219.1 - 0.0014 18.1 0.4 0.012 15.1 0.0 2.2 1 1 2 3 3 3 1 Elongation complex protein 6 Methyltransf_23 PF13489.6 EFX03220.1 - 1.3e-11 44.6 0.0 2.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03220.1 - 0.00049 20.8 0.0 0.0047 17.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03220.1 - 0.0091 15.8 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03220.1 - 0.084 13.6 0.0 0.38 11.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EFX03220.1 - 0.22 11.6 0.0 0.3 11.2 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase EMP70 PF02990.16 EFX03222.1 - 2.1e-204 680.1 0.1 2.6e-204 679.7 0.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DNA_ligase_A_M PF01068.21 EFX03223.1 - 2.5e-59 200.4 0.0 4.6e-59 199.5 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFX03223.1 - 5.8e-43 147.2 0.5 1.3e-42 146.0 0.0 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFX03223.1 - 3.6e-26 91.6 0.0 1.1e-25 90.1 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EFX03223.1 - 2.1e-05 24.9 0.0 3.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 RNA ligase ORC6 PF05460.13 EFX03223.1 - 0.035 13.4 8.9 0.062 12.6 8.9 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) MatE PF01554.18 EFX03224.1 - 4.8e-55 185.6 20.0 5.4e-28 97.7 8.9 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EFX03224.1 - 2.7e-05 24.2 6.6 2.7e-05 24.2 6.6 4.2 2 2 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Dabb PF07876.12 EFX03226.1 - 4.1e-25 88.2 0.1 4.7e-25 88.1 0.1 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Ras PF00071.22 EFX03227.1 - 2.1e-52 177.0 0.0 2.5e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX03227.1 - 5.5e-19 68.6 0.0 7.4e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX03227.1 - 3.2e-06 26.7 0.0 4.4e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFX03227.1 - 0.17 11.4 0.1 0.94 9.0 0.0 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain SnoaL_2 PF12680.7 EFX03228.1 - 3.4e-05 24.4 0.0 4.7e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 EFX03228.1 - 0.01 16.0 0.1 0.015 15.5 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain ATP-synt PF00231.19 EFX03229.1 - 8.7e-81 271.7 1.2 1.1e-80 271.4 1.2 1.0 1 0 0 1 1 1 1 ATP synthase DUF4325 PF14213.6 EFX03229.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) Methyltransf_3 PF01596.17 EFX03230.1 - 7.8e-30 103.6 0.0 1.5e-28 99.4 0.0 2.0 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EFX03230.1 - 2.4e-10 41.4 0.0 9.3e-10 39.5 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EFX03230.1 - 2.1e-09 37.5 0.0 3.9e-09 36.6 0.0 1.4 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFX03230.1 - 1.5e-06 28.1 0.0 2.2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03230.1 - 2.2e-05 25.1 0.0 4.6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFX03230.1 - 0.09 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase UTP15_C PF09384.10 EFX03231.1 - 3.5e-47 159.8 0.0 5.5e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EFX03231.1 - 3.4e-12 46.7 13.5 0.0022 18.8 0.0 6.3 7 1 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX03231.1 - 0.00042 20.6 0.1 15 6.0 0.0 4.6 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TMEM171 PF15471.6 EFX03232.1 - 0.17 10.9 1.4 0.19 10.7 1.4 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 LAP1C PF05609.12 EFX03232.1 - 0.91 8.5 14.3 1.1 8.3 14.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Alpha_GJ PF03229.13 EFX03232.1 - 1.2 9.7 8.3 0.53 10.9 5.6 1.8 1 1 1 2 2 2 0 Alphavirus glycoprotein J Proteasome PF00227.26 EFX03233.1 - 4e-42 143.9 0.0 4.8e-42 143.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit CFEM PF05730.11 EFX03234.1 - 6.6e-12 45.4 6.6 1.2e-11 44.5 6.6 1.5 1 0 0 1 1 1 1 CFEM domain Fungal_trans_2 PF11951.8 EFX03235.1 - 0.0011 17.9 0.2 0.0017 17.3 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain OPA3 PF07047.12 EFX03236.1 - 1.5e-41 141.1 2.3 2.4e-41 140.4 2.3 1.4 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF4551 PF15087.6 EFX03236.1 - 0.17 10.6 3.0 0.25 10.1 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) BRF1 PF07741.13 EFX03236.1 - 0.21 11.9 4.3 0.53 10.7 4.3 1.7 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Nipped-B_C PF12830.7 EFX03237.1 - 1.9e-45 155.2 0.3 6.2e-44 150.2 0.1 2.9 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EFX03237.1 - 7.5e-06 26.1 0.6 0.0005 20.3 0.2 3.1 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 EFX03237.1 - 0.004 17.2 0.3 0.14 12.2 0.0 3.1 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFX03237.1 - 0.013 15.7 1.4 43 4.7 0.1 5.0 4 0 0 4 4 4 0 HEAT repeat Adaptin_N PF01602.20 EFX03237.1 - 0.03 12.9 0.3 0.16 10.5 0.0 2.3 3 0 0 3 3 3 0 Adaptin N terminal region MFS_1 PF07690.16 EFX03238.1 - 6.9e-20 71.3 6.7 6.9e-20 71.3 6.7 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EFX03240.1 - 1.6e-34 119.4 50.9 2.1e-33 115.7 51.1 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily adh_short PF00106.25 EFX03240.1 - 2.3e-23 82.7 0.9 3.7e-23 82.0 0.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX03240.1 - 5.1e-16 58.9 0.2 9.2e-16 58.1 0.2 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase TRI12 PF06609.13 EFX03240.1 - 2.4e-13 49.4 27.0 3.5e-13 48.9 27.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) KR PF08659.10 EFX03240.1 - 4.3e-10 39.8 0.6 7.9e-10 38.9 0.6 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFX03240.1 - 1.9e-05 23.9 0.2 3.2e-05 23.2 0.2 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFX03240.1 - 0.00034 20.1 0.5 0.00094 18.7 0.5 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF4169 PF13770.6 EFX03240.1 - 0.017 15.4 3.3 0.036 14.3 3.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) DUF4407 PF14362.6 EFX03240.1 - 0.38 10.1 2.8 0.23 10.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Pkinase PF00069.25 EFX03242.1 - 1.5e-49 168.8 0.0 2.2e-49 168.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03242.1 - 4.4e-27 95.0 0.0 5.5e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX03242.1 - 0.0029 16.9 0.0 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFX03242.1 - 0.0057 16.0 0.0 0.0097 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFX03242.1 - 0.049 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFX03242.1 - 0.12 12.3 0.2 0.55 10.1 0.0 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family ETF PF01012.21 EFX03243.1 - 1.2e-40 139.4 2.3 1.5e-40 139.0 2.3 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain SET PF00856.28 EFX03245.1 - 0.00012 22.5 0.0 0.00048 20.5 0.0 1.9 2 0 0 2 2 2 1 SET domain Homeobox_KN PF05920.11 EFX03246.1 - 1.5e-14 53.5 0.5 3.9e-14 52.3 0.5 1.8 1 0 0 1 1 1 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.16 EFX03246.1 - 2e-14 53.3 0.4 0.0026 17.8 0.1 6.3 6 1 0 6 6 6 3 Tc5 transposase DNA-binding domain Homeodomain PF00046.29 EFX03246.1 - 8e-05 22.4 0.2 0.00023 21.0 0.2 1.7 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 EFX03246.1 - 0.0021 18.7 3.7 0.0021 18.7 3.7 5.2 5 0 0 5 5 5 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EFX03246.1 - 0.018 15.5 3.9 0.018 15.5 3.9 5.0 5 0 0 5 5 5 0 Zinc finger, C2H2 type Zn_clus PF00172.18 EFX03246.1 - 6.2 7.0 8.0 22 5.3 8.0 2.0 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_jaz PF12171.8 EFX03246.1 - 6.4 7.2 7.8 0.85 10.0 2.8 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Sedlin_N PF04628.13 EFX03247.1 - 1.3e-42 145.0 0.0 1.5e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EFX03247.1 - 0.026 14.4 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Sybindin-like family Cloacin_immun PF03513.14 EFX03247.1 - 0.058 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Cloacin immunity protein Lon_C PF05362.13 EFX03248.1 - 9.8e-64 214.7 0.0 1.7e-63 213.9 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EFX03248.1 - 1.9e-32 112.9 0.1 6e-32 111.2 0.0 1.9 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EFX03248.1 - 5.8e-22 78.5 0.0 2.2e-21 76.7 0.0 2.1 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 EFX03248.1 - 4.7e-07 29.7 0.0 1.5e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EFX03248.1 - 4.8e-07 29.8 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFX03248.1 - 1.4e-06 28.5 0.0 4.5e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFX03248.1 - 5.7e-05 23.4 0.0 0.00082 19.7 0.0 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFX03248.1 - 6.9e-05 22.6 0.5 0.00069 19.4 0.0 2.8 4 0 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 EFX03248.1 - 0.0001 21.4 0.0 0.0002 20.4 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 EFX03248.1 - 0.00026 21.4 0.1 0.0018 18.7 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EFX03248.1 - 0.011 15.7 0.0 0.04 14.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFX03248.1 - 0.017 14.8 0.0 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 EFX03248.1 - 0.02 15.5 0.2 0.074 13.6 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 EFX03248.1 - 0.025 14.3 0.2 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain CHASE8 PF17152.4 EFX03248.1 - 0.031 14.5 0.0 0.1 12.8 0.0 1.9 1 0 0 1 1 1 0 Periplasmic sensor domain RNA_helicase PF00910.22 EFX03248.1 - 0.048 14.1 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 EFX03248.1 - 0.058 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 EFX03248.1 - 0.078 12.9 0.1 1.6 8.6 0.0 2.6 2 1 1 3 3 2 0 NTPase AAA_28 PF13521.6 EFX03248.1 - 0.089 13.0 0.0 21 5.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFX03248.1 - 0.091 13.3 0.6 0.92 10.0 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 EFX03248.1 - 0.11 12.0 0.7 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region ClpB_D2-small PF10431.9 EFX03248.1 - 0.3 11.2 3.3 0.19 11.8 0.2 2.2 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Fungal_trans PF04082.18 EFX03249.1 - 8.3e-10 38.1 0.0 1.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03249.1 - 5e-06 26.5 11.7 9.6e-06 25.6 11.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-T_C PF15511.6 EFX03250.1 - 1.4e-08 34.8 0.1 1.8e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EFX03250.1 - 0.00012 22.2 0.1 0.00017 21.7 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EFX03250.1 - 0.00016 22.0 0.1 0.00019 21.8 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFX03250.1 - 0.0005 20.4 0.1 0.00065 20.0 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFX03250.1 - 0.00056 20.2 0.0 0.001 19.3 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFX03250.1 - 0.013 15.6 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFX03250.1 - 0.026 14.5 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EFX03250.1 - 0.17 11.6 0.1 0.21 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) zf-RING_2 PF13639.6 EFX03251.1 - 6e-10 39.3 2.9 9e-10 38.7 2.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EFX03251.1 - 2.5e-05 24.2 0.3 4.1e-05 23.6 0.3 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFX03251.1 - 3.1e-05 24.2 4.7 0.00013 22.2 4.7 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFX03251.1 - 3.3e-05 23.6 2.4 7.6e-05 22.5 2.4 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX03251.1 - 0.00078 19.2 1.3 0.0014 18.5 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX03251.1 - 0.003 17.4 1.3 0.36 10.7 0.5 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFX03251.1 - 0.0042 17.1 0.8 0.012 15.6 0.9 1.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFX03251.1 - 0.0067 16.3 1.2 0.011 15.5 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 EFX03251.1 - 0.02 14.7 1.2 0.25 11.2 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_11 PF17123.5 EFX03251.1 - 0.025 14.3 0.9 0.025 14.3 0.9 1.9 2 0 0 2 2 2 0 RING-like zinc finger zf-UDP PF14569.6 EFX03251.1 - 0.029 14.5 4.0 0.2 11.8 4.0 2.1 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 EFX03251.1 - 0.042 13.6 2.3 0.12 12.1 2.5 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 EFX03251.1 - 0.069 13.0 5.4 0.17 11.8 2.9 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RNF220 PF15926.5 EFX03251.1 - 0.74 9.4 3.1 2.6 7.6 3.1 1.9 1 1 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Prok-RING_1 PF14446.6 EFX03251.1 - 0.87 9.6 3.8 7.2 6.6 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-C2H2_12 PF18112.1 EFX03251.1 - 1.5 9.4 3.7 8.2 7.0 0.1 2.8 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain PPR_2 PF13041.6 EFX03252.1 - 3.1e-19 68.9 0.0 3.5e-07 30.3 0.0 6.7 5 2 2 7 7 7 4 PPR repeat family PPR PF01535.20 EFX03252.1 - 5e-11 42.1 0.1 0.55 10.6 0.0 7.0 7 0 0 7 7 7 3 PPR repeat PPR_3 PF13812.6 EFX03252.1 - 1.8e-07 31.1 0.0 0.05 13.7 0.0 5.6 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EFX03252.1 - 1.3e-06 28.0 0.0 0.063 12.6 0.0 4.1 3 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFX03252.1 - 0.004 16.8 0.0 0.19 11.5 0.0 3.6 4 0 0 4 4 4 1 PPR repeat FGGY_C PF02782.16 EFX03253.1 - 1.1e-71 240.6 1.2 2.3e-71 239.6 0.7 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFX03253.1 - 6.2e-65 219.2 0.0 8.4e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Cu-oxidase_2 PF07731.14 EFX03254.1 - 1.1e-43 148.2 5.4 2.8e-36 124.2 0.6 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFX03254.1 - 5.5e-42 142.5 1.7 1.1e-38 131.8 0.3 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX03254.1 - 1.4e-24 87.0 1.6 3.3e-23 82.6 0.1 3.0 3 1 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 EFX03254.1 - 0.06 13.5 0.0 22 5.2 0.0 3.9 3 1 0 3 3 3 0 Cupredoxin-like domain CAP_assoc_N PF14504.6 EFX03254.1 - 0.11 12.2 0.0 0.36 10.6 0.0 1.8 1 0 0 1 1 1 0 CAP-associated N-terminal Proteasome PF00227.26 EFX03255.1 - 1.1e-35 122.8 0.0 1.3e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Sigma54_AID PF00309.20 EFX03255.1 - 0.091 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) Chitin_synth_2 PF03142.15 EFX03256.1 - 8e-288 955.3 0.1 1e-287 955.0 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EFX03256.1 - 7.9e-11 42.2 10.1 1e-09 38.6 10.1 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFX03256.1 - 2.6e-09 37.3 0.0 3.1e-08 33.8 0.0 2.5 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EFX03256.1 - 0.0015 18.1 0.2 0.0047 16.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EFX03256.1 - 0.0087 15.9 0.0 0.042 13.7 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 TetR_C_23 PF17931.1 EFX03256.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain SRPRB PF09439.10 EFX03257.1 - 7.7e-26 90.6 0.0 2.2e-25 89.2 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFX03257.1 - 0.00029 20.9 0.0 0.00047 20.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EFX03257.1 - 0.0018 17.8 0.0 0.033 13.6 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_30 PF13604.6 EFX03257.1 - 0.0024 17.6 0.1 0.0037 17.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX03257.1 - 0.0047 17.3 0.1 0.011 16.1 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFX03257.1 - 0.0047 17.2 0.0 0.008 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFX03257.1 - 0.0074 16.8 0.0 0.011 16.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter TniB PF05621.11 EFX03257.1 - 0.015 14.7 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein ATP_bind_1 PF03029.17 EFX03257.1 - 0.015 15.1 0.0 5.3 6.8 0.0 2.3 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFX03257.1 - 0.016 15.1 0.0 0.27 11.1 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase cobW PF02492.19 EFX03257.1 - 0.041 13.5 0.1 3.8 7.1 0.1 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EFX03257.1 - 0.068 12.7 0.0 0.39 10.2 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Septin PF00735.18 EFX03257.1 - 0.096 11.9 0.0 0.19 11.0 0.0 1.4 2 0 0 2 2 2 0 Septin PWI PF01480.17 EFX03258.1 - 2.4e-22 79.0 0.0 3.9e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 PWI domain HSA PF07529.13 EFX03259.1 - 6.3e-13 48.9 0.2 6.3e-13 48.9 0.2 3.3 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.6 EFX03259.1 - 9.2e-13 48.2 0.1 3e-12 46.6 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFX03259.1 - 0.00019 21.6 0.2 0.00044 20.4 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Cdh1_DBD_1 PF18196.1 EFX03259.1 - 5.3 7.4 9.8 1.4 9.3 0.6 3.2 1 1 1 2 2 2 0 Chromodomain helicase DNA-binding domain 1 BCIP PF13862.6 EFX03260.1 - 6.3e-60 202.5 0.0 8.4e-60 202.1 0.0 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Methyltransf_23 PF13489.6 EFX03261.1 - 2.8e-19 69.6 0.0 9e-19 67.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03261.1 - 6.4e-12 46.0 0.0 2.2e-11 44.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03261.1 - 5.2e-11 43.0 0.0 1.7e-10 41.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03261.1 - 4.6e-07 30.5 0.0 1.9e-06 28.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03261.1 - 7.7e-05 22.5 0.0 0.00064 19.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX03261.1 - 0.0052 16.4 0.1 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 EFX03261.1 - 0.0094 15.4 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EFX03261.1 - 0.023 14.5 0.0 0.058 13.1 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase Ubie_methyltran PF01209.18 EFX03261.1 - 0.024 14.0 0.0 0.076 12.3 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EFX03261.1 - 0.062 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EFX03261.1 - 0.17 11.4 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Transferase PF02458.15 EFX03263.1 - 3.6e-10 39.1 0.0 5.1e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Transferase family CBFD_NFYB_HMF PF00808.23 EFX03264.1 - 1.2e-11 44.7 1.9 1.8e-11 44.1 1.9 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFX03264.1 - 0.0059 17.0 0.2 0.0059 17.0 0.2 3.2 4 0 0 4 4 4 1 Core histone H2A/H2B/H3/H4 Tim44 PF04280.15 EFX03264.1 - 0.11 12.6 0.2 0.2 11.8 0.2 1.4 1 0 0 1 1 1 0 Tim44-like domain adh_short_C2 PF13561.6 EFX03265.1 - 1e-49 169.2 0.0 2e-49 168.3 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX03265.1 - 2.7e-37 128.1 0.0 7e-37 126.8 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX03265.1 - 3.2e-07 30.4 0.4 4.9e-07 29.8 0.4 1.2 1 0 0 1 1 1 1 KR domain AATase PF07247.12 EFX03266.1 - 6.7e-10 38.1 0.0 8.7e-10 37.7 0.0 1.1 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EFX03266.1 - 1.5e-05 23.9 0.7 0.00018 20.3 0.7 1.9 1 1 0 1 1 1 1 Condensation domain peroxidase PF00141.23 EFX03267.1 - 5.9e-47 160.3 0.0 1e-46 159.5 0.0 1.4 1 0 0 1 1 1 1 Peroxidase Acetyltransf_1 PF00583.25 EFX03268.1 - 1.4e-05 25.3 0.0 2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX03268.1 - 0.0018 18.2 0.0 0.0028 17.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX03268.1 - 0.093 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Nha1_C PF08619.10 EFX03269.1 - 1.4e-136 456.4 38.9 1.8e-136 456.1 38.9 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EFX03269.1 - 2.4e-77 260.3 24.3 2.8e-77 260.1 24.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 EFX03269.1 - 0.83 9.8 4.5 0.32 11.1 0.6 2.2 2 0 0 2 2 2 0 YrhC-like protein DUF21 PF01595.20 EFX03269.1 - 3.4 7.3 12.0 5.7 6.6 4.6 2.6 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain Ribosomal_L7Ae PF01248.26 EFX03270.1 - 6.9e-22 77.0 0.1 8.9e-22 76.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EFX03270.1 - 0.00023 21.3 0.0 0.00023 21.3 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Amino_oxidase PF01593.24 EFX03271.1 - 2e-22 80.1 0.1 3.6e-22 79.3 0.1 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Amino_oxidase PF01593.24 EFX03272.1 - 4.3e-72 243.8 0.5 2.9e-60 204.8 0.0 2.7 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 EFX03272.1 - 7.3e-13 48.7 0.0 1.5e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 EFX03272.1 - 1.5e-06 28.3 0.0 4.6e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.19 EFX03272.1 - 0.00012 22.5 1.3 0.00034 21.0 0.2 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFX03272.1 - 0.00051 20.6 0.3 0.0015 19.1 0.3 1.8 1 0 0 1 1 1 1 HMG-box domain DAO PF01266.24 EFX03272.1 - 0.0068 16.0 0.0 0.021 14.4 0.0 1.9 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX03272.1 - 0.009 15.3 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EFX03273.1 - 6.4e-28 97.7 25.0 6.4e-28 97.7 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ECF_trnsprt PF12822.7 EFX03273.1 - 0.016 15.3 9.0 0.046 13.8 9.0 1.8 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Fungal_trans PF04082.18 EFX03274.1 - 3.3e-19 68.9 0.0 6.4e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Keratin_matx PF04579.12 EFX03274.1 - 0.061 13.7 0.2 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 Keratin, high-sulphur matrix protein Striatin PF08232.12 EFX03274.1 - 2.7 8.6 4.4 0.57 10.8 0.4 1.8 2 0 0 2 2 2 0 Striatin family DAO PF01266.24 EFX03276.1 - 8e-26 91.5 1.8 1e-25 91.1 1.8 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase ThiF PF00899.21 EFX03276.1 - 0.0021 17.5 0.0 0.0041 16.5 0.0 1.4 1 0 0 1 1 1 1 ThiF family NAD_binding_8 PF13450.6 EFX03276.1 - 0.0022 18.2 0.1 0.0063 16.7 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX03276.1 - 0.0042 16.4 0.0 0.16 11.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PglD_N PF17836.1 EFX03276.1 - 0.03 14.9 0.0 6.5 7.5 0.0 2.6 2 0 0 2 2 2 0 PglD N-terminal domain Glu_dehyd_C PF16912.5 EFX03276.1 - 0.076 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus TrkA_N PF02254.18 EFX03276.1 - 0.083 13.1 0.1 0.38 11.0 0.0 2.2 2 1 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 EFX03276.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF1964 PF09244.10 EFX03276.1 - 0.13 12.7 1.2 0.92 10.0 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1964) Shikimate_DH PF01488.20 EFX03276.1 - 0.17 11.9 0.0 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DHquinase_I PF01487.15 EFX03277.1 - 4.2e-46 158.0 0.0 5.7e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Type I 3-dehydroquinase Ribosomal_L16 PF00252.18 EFX03278.1 - 4.2e-45 153.0 0.0 5.4e-45 152.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e WGG PF10273.9 EFX03279.1 - 7e-25 87.5 0.3 1.3e-24 86.6 0.3 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 EFX03279.1 - 0.0013 18.8 0.1 0.0077 16.3 0.1 2.2 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain NOA36 PF06524.12 EFX03279.1 - 0.018 14.4 7.3 0.023 14.0 7.3 1.1 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 EFX03279.1 - 0.2 11.7 2.5 0.27 11.3 2.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal CAF20 PF17052.5 EFX03279.1 - 0.32 11.1 0.1 0.32 11.1 0.1 2.1 1 1 1 2 2 2 0 Cap associated factor YL1 PF05764.13 EFX03279.1 - 0.82 9.7 8.6 0.86 9.7 8.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein SDA1 PF05285.12 EFX03279.1 - 1.2 8.4 8.5 1.6 8.1 8.5 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EFX03279.1 - 1.5 7.0 5.2 1.5 7.0 5.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 EFX03279.1 - 3.8 6.5 16.7 5 6.1 16.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) LSM PF01423.22 EFX03280.1 - 2.6e-17 62.3 0.1 3.7e-17 61.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain DUF2845 PF11006.8 EFX03280.1 - 0.089 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) Glyco_hydro_20 PF00728.22 EFX03281.1 - 6.4e-81 272.5 0.0 8.2e-81 272.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFX03281.1 - 1.9e-25 90.1 0.1 3.1e-25 89.4 0.1 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFX03281.1 - 5.2e-07 30.5 0.5 6.6e-06 26.9 0.5 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Zn_clus PF00172.18 EFX03282.1 - 6.8e-05 22.9 11.3 6.8e-05 22.9 11.3 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX03282.1 - 0.00031 19.9 0.6 0.002 17.2 0.1 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFX03282.1 - 0.026 15.0 4.6 0.12 12.9 4.6 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type CbiM PF01891.16 EFX03282.1 - 0.9 9.3 4.6 1.2 9.0 0.3 2.2 2 0 0 2 2 2 0 Cobalt uptake substrate-specific transmembrane region Aldedh PF00171.22 EFX03283.1 - 5.2e-135 450.5 3.3 4.1e-133 444.3 3.3 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Homeodomain PF00046.29 EFX03284.1 - 2.4e-08 33.7 0.3 4.8e-08 32.7 0.3 1.5 1 0 0 1 1 1 1 Homeodomain Methyltransf_23 PF13489.6 EFX03285.1 - 1.4e-15 57.5 0.0 2.4e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03285.1 - 2.4e-09 37.7 0.0 5.7e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03285.1 - 1.9e-07 31.7 0.0 6.5e-07 30.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03285.1 - 2.4e-07 30.7 0.1 1.3e-06 28.3 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03285.1 - 3.7e-07 30.7 0.1 1.1e-06 29.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 EFX03285.1 - 0.00031 20.1 0.0 0.00049 19.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 EFX03285.1 - 0.0006 19.2 0.0 0.0024 17.3 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFX03285.1 - 0.00077 19.0 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 EFX03285.1 - 0.011 15.8 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 EFX03285.1 - 0.022 14.3 0.0 0.075 12.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain CMAS PF02353.20 EFX03285.1 - 0.034 13.5 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFX03286.1 - 1.7e-18 67.0 0.0 2.5e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03286.1 - 2.4e-11 44.2 0.0 7.6e-11 42.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03286.1 - 8.9e-10 39.1 0.0 1.9e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03286.1 - 1.5e-07 32.0 0.0 1e-06 29.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX03286.1 - 6.9e-06 25.6 0.0 6.8e-05 22.3 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFX03286.1 - 1.9e-05 24.5 0.0 0.043 13.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EFX03286.1 - 0.0063 16.1 0.0 0.021 14.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX03286.1 - 0.014 14.9 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.9 EFX03286.1 - 0.021 14.6 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF4357 PF14267.6 EFX03286.1 - 0.054 13.4 0.0 0.054 13.4 0.0 2.2 2 0 0 2 2 1 0 Domain of unknown function (DUF4357) PrmA PF06325.13 EFX03286.1 - 0.06 12.7 0.0 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 EFX03286.1 - 0.086 12.6 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.18 EFX03286.1 - 0.16 11.3 0.0 0.33 10.2 0.0 1.5 1 1 0 1 1 1 0 O-methyltransferase domain DHO_dh PF01180.21 EFX03287.1 - 6.9e-17 61.6 0.0 1.2e-16 60.8 0.0 1.3 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 EFX03287.1 - 0.0069 15.8 3.5 0.01 15.2 3.5 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase TCTP PF00838.17 EFX03288.1 - 1.9e-71 239.8 2.8 2.1e-71 239.6 2.8 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF4559 PF15112.6 EFX03288.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Mus7 PF09462.10 EFX03288.1 - 0.13 11.1 0.1 0.16 10.8 0.1 1.1 1 0 0 1 1 1 0 Mus7/MMS22 family Neurochondrin PF05536.11 EFX03289.1 - 4.2e-61 207.1 0.0 6.8e-61 206.4 0.0 1.3 1 0 0 1 1 1 1 Neurochondrin RIX1 PF08167.12 EFX03289.1 - 0.0056 16.4 0.2 0.13 12.0 0.0 2.7 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis WAPL PF07814.13 EFX03289.1 - 0.0098 14.7 0.1 0.021 13.6 0.0 1.5 2 0 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin MAGE PF01454.19 EFX03290.1 - 1.8e-66 223.9 0.0 2.7e-66 223.3 0.0 1.3 1 0 0 1 1 1 1 MAGE family Pes-10 PF07149.11 EFX03290.1 - 0.39 9.7 0.9 0.54 9.3 0.9 1.1 1 0 0 1 1 1 0 Pes-10 DNA_pol_phi PF04931.13 EFX03290.1 - 2.9 5.9 6.1 4.2 5.3 6.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 EFX03290.1 - 5.5 7.4 8.5 18 5.8 8.5 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_S10 PF00450.22 EFX03291.1 - 5.6e-114 381.8 0.0 7.3e-114 381.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Zn_clus PF00172.18 EFX03292.1 - 2.7e-07 30.6 12.1 4.5e-07 29.9 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CIA30 PF08547.12 EFX03293.1 - 4.4e-44 150.3 0.0 6.7e-44 149.7 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) DAO PF01266.24 EFX03293.1 - 3.6e-40 138.6 1.1 9.3e-40 137.3 1.1 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX03293.1 - 0.0062 16.5 0.7 0.46 10.5 0.1 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFX03293.1 - 0.034 14.4 0.5 0.61 10.3 0.1 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX03293.1 - 0.13 11.3 0.8 3.8 6.5 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain P16-Arc PF04699.14 EFX03294.1 - 0.0031 18.0 0.0 0.0031 18.0 0.0 3.3 3 0 0 3 3 3 1 ARP2/3 complex 16 kDa subunit (p16-Arc) zf-C2H2 PF00096.26 EFX03294.1 - 0.0068 16.8 22.0 0.023 15.2 1.2 4.6 4 1 0 4 4 4 3 Zinc finger, C2H2 type Raptor_N PF14538.6 EFX03294.1 - 0.029 14.3 0.0 0.029 14.3 0.0 2.1 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain NTP_transferase PF00483.23 EFX03295.1 - 1.4e-52 178.7 0.0 3.1e-52 177.6 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EFX03295.1 - 5.6e-14 51.2 8.9 1.1e-09 37.6 2.4 3.8 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFX03295.1 - 2.8e-11 44.0 0.0 4.2e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EFX03295.1 - 4.1e-07 29.6 7.1 2.2e-06 27.3 0.4 3.1 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EFX03295.1 - 0.00054 18.2 0.1 0.0018 16.5 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 EFX03295.1 - 0.0068 16.3 0.0 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase IspD PF01128.19 EFX03295.1 - 0.076 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase PI3Ka PF00613.20 EFX03298.1 - 1.3e-59 200.7 0.0 2e-59 200.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFX03298.1 - 1.5e-46 159.2 0.0 3.6e-44 151.5 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EFX03298.1 - 4e-27 94.8 0.0 7.9e-26 90.6 0.0 2.3 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 zf-RING_11 PF17123.5 EFX03299.1 - 1.5e-08 34.2 1.0 1.5e-08 34.2 1.0 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 EFX03299.1 - 1.2e-05 25.5 7.2 8.4e-05 22.8 0.2 2.3 2 0 0 2 2 2 1 Ring finger domain Zn-ribbon_8 PF09723.10 EFX03299.1 - 0.0058 16.7 1.1 0.015 15.4 1.1 1.7 1 0 0 1 1 1 1 Zinc ribbon domain zinc_ribbon_9 PF14369.6 EFX03299.1 - 0.0071 16.6 4.4 0.015 15.5 4.4 1.5 1 0 0 1 1 1 1 zinc-ribbon HypA PF01155.19 EFX03299.1 - 0.028 14.4 0.1 0.028 14.4 0.1 1.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_2 PF13923.6 EFX03299.1 - 0.065 13.1 0.3 0.065 13.1 0.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Chisel PF15355.6 EFX03299.1 - 0.15 12.3 0.2 0.88 9.8 0.0 2.2 2 0 0 2 2 2 0 Stretch-responsive small skeletal muscle X protein, Chisel Lar_restr_allev PF14354.6 EFX03299.1 - 0.28 11.6 1.5 7.5 7.0 0.3 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar zf-C3HC4_3 PF13920.6 EFX03299.1 - 0.9 9.5 5.5 1.7 8.6 0.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX03299.1 - 1.5 8.7 8.8 4.4 7.3 0.4 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HEAT_2 PF13646.6 EFX03300.1 - 5.7e-12 45.9 10.9 5.1e-11 42.8 0.2 4.1 2 2 1 3 3 3 1 HEAT repeats HEAT_PBS PF03130.16 EFX03300.1 - 3.6e-11 42.6 9.0 0.031 14.9 0.0 6.2 5 2 0 5 5 5 3 PBS lyase HEAT-like repeat HEAT PF02985.22 EFX03300.1 - 0.0036 17.4 5.9 3.9 8.0 0.0 5.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EFX03300.1 - 2.1 8.9 11.0 0.77 10.3 1.7 4.1 3 2 0 3 3 3 0 HEAT-like repeat GDPD PF03009.17 EFX03301.1 - 1.4e-27 97.1 0.0 1.9e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EFX03301.1 - 0.00031 21.1 0.9 0.00077 19.8 0.9 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SbcD_C PF12320.8 EFX03301.1 - 0.098 13.0 0.2 0.23 11.8 0.2 1.5 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain zf-CCHC PF00098.23 EFX03302.1 - 3.4e-56 184.9 64.1 8.2e-10 38.3 3.6 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EFX03302.1 - 1e-13 50.7 39.8 0.0042 16.8 0.4 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EFX03302.1 - 3.6e-08 33.2 42.8 0.08 12.9 0.9 6.9 3 2 4 7 7 7 6 Zinc knuckle zf-CCHC_5 PF14787.6 EFX03302.1 - 0.00048 19.8 40.5 0.3 10.8 0.9 7.1 5 2 2 7 7 7 4 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 EFX03302.1 - 0.0028 17.5 54.7 0.055 13.3 2.0 6.7 5 2 2 7 7 7 6 Zinc knuckle zf-CCHC_2 PF13696.6 EFX03302.1 - 0.013 15.3 1.7 0.013 15.3 1.7 7.2 7 1 0 7 7 7 0 Zinc knuckle TRAF6_Z2 PF18048.1 EFX03302.1 - 0.46 10.6 21.4 31 4.8 0.1 7.0 7 0 0 7 7 7 0 TNF receptor-associated factor 6 zinc finger 2 Mucin PF01456.17 EFX03304.1 - 0.16 12.0 6.9 0.3 11.1 6.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein HHV-5_US34A PF17087.5 EFX03304.1 - 0.84 9.8 3.2 1.4 9.1 3.2 1.3 1 0 0 1 1 1 0 Herpesvirus US34A protein family Med21 PF11221.8 EFX03305.1 - 1e-43 149.1 8.3 1.1e-43 148.9 8.3 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex RACo_linker PF17650.1 EFX03305.1 - 0.025 14.4 0.2 0.048 13.5 0.2 1.5 1 0 0 1 1 1 0 RACo linker region Herpes_UL6 PF01763.16 EFX03305.1 - 0.037 12.6 0.8 0.038 12.5 0.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Med9 PF07544.13 EFX03305.1 - 0.047 13.8 0.8 0.047 13.8 0.8 2.9 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 TMF_DNA_bd PF12329.8 EFX03305.1 - 0.2 11.7 11.1 0.18 11.9 8.2 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 EFX03305.1 - 1.2 9.7 10.5 2.1 8.9 10.5 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region GAS PF13851.6 EFX03305.1 - 1.2 8.4 10.9 1.4 8.3 6.5 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Pyr_redox_2 PF07992.14 EFX03306.1 - 1.7e-46 158.8 0.3 4.4e-32 111.5 0.1 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX03306.1 - 4.1e-19 68.9 1.3 3.2e-13 50.0 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFX03306.1 - 1.6e-18 67.0 0.0 3.4e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GIDA PF01134.22 EFX03306.1 - 1.7e-06 27.4 2.2 2.7e-06 26.7 2.2 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFX03306.1 - 1.2e-05 24.9 3.4 0.00076 18.9 1.8 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFX03306.1 - 0.00034 20.0 0.1 0.33 10.2 0.5 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX03306.1 - 0.0034 17.6 4.8 0.021 15.1 1.9 2.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX03306.1 - 0.0035 16.5 5.4 0.0035 16.5 5.4 2.2 1 1 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 EFX03306.1 - 0.0072 15.6 1.4 0.23 10.7 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFX03306.1 - 0.0076 15.9 2.0 0.012 15.2 0.6 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase PHY PF00360.20 EFX03306.1 - 0.0078 15.5 0.0 0.023 14.0 0.0 1.7 2 0 0 2 2 2 1 Phytochrome region K_oxygenase PF13434.6 EFX03306.1 - 0.0085 15.3 0.0 0.59 9.2 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EFX03306.1 - 0.034 13.4 0.1 0.063 12.5 0.1 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EFX03306.1 - 0.037 12.7 0.3 0.56 8.9 0.7 2.1 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.6 EFX03306.1 - 0.13 12.7 0.8 2.1 8.8 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding Oxysterol_BP PF01237.18 EFX03307.1 - 1.7e-83 280.5 0.1 5e-81 272.4 0.1 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Glycogen_syn PF05693.13 EFX03308.1 - 0 1165.3 0.0 0 1165.1 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_5 PF08323.11 EFX03308.1 - 2e-05 24.4 0.1 4.3e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EFX03308.1 - 2.6e-05 23.8 0.0 0.013 15.0 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFX03308.1 - 8.8e-05 22.9 0.0 0.16 12.4 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFX03308.1 - 0.0001 22.4 0.1 0.0002 21.4 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EFX03308.1 - 0.00096 19.6 0.0 0.0025 18.2 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain MFS_1 PF07690.16 EFX03310.1 - 3.2e-14 52.6 44.1 1.4e-12 47.3 16.0 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03310.1 - 2.9e-05 23.1 0.1 6.8e-05 21.9 0.1 1.6 1 0 0 1 1 1 1 Sugar (and other) transporter Vac7 PF12751.7 EFX03311.1 - 1.8e-156 521.4 0.3 1.8e-156 521.4 0.3 2.5 3 0 0 3 3 3 1 Vacuolar segregation subunit 7 AltA1 PF16541.5 EFX03312.1 - 1.3e-13 51.7 0.9 1.9e-13 51.2 0.9 1.2 1 0 0 1 1 1 1 Alternaria alternata allergen 1 Pro-rich_19 PF15455.6 EFX03312.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Proline-rich 19 MFAP1 PF06991.11 EFX03313.1 - 0.24 11.2 3.0 15 5.4 1.7 2.2 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing But2 PF09792.9 EFX03314.1 - 2e-43 148.2 1.8 2.4e-43 147.9 1.8 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain SKG6 PF08693.10 EFX03316.1 - 5.6e-08 32.1 6.1 1.4e-07 30.7 6.1 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 EFX03316.1 - 0.00022 21.1 2.6 0.00043 20.1 2.1 1.8 1 1 1 2 2 2 1 Mid2 like cell wall stress sensor Podoplanin PF05808.11 EFX03316.1 - 0.0027 17.8 3.9 0.004 17.3 3.9 1.3 1 0 0 1 1 1 1 Podoplanin CcmD PF04995.14 EFX03316.1 - 0.058 13.5 1.2 0.11 12.6 1.2 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Amnionless PF14828.6 EFX03316.1 - 0.15 10.9 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Amnionless Syndecan PF01034.20 EFX03316.1 - 0.32 10.9 3.0 0.69 9.9 3.0 1.5 1 0 0 1 1 1 0 Syndecan domain Ribosomal_L7Ae PF01248.26 EFX03317.1 - 1.2e-23 82.6 0.0 1.4e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DEAD PF00270.29 EFX03318.1 - 1.5e-45 155.1 0.0 1.7e-44 151.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX03318.1 - 1.5e-33 115.4 0.0 4.2e-30 104.3 0.2 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFX03318.1 - 5.9e-05 22.4 0.1 0.00011 21.5 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 EFX03318.1 - 0.0036 16.2 0.0 0.0069 15.2 0.0 1.4 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ResIII PF04851.15 EFX03318.1 - 0.014 15.4 0.0 0.051 13.6 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Fungal_trans PF04082.18 EFX03319.1 - 5.9e-39 133.7 0.3 5.9e-39 133.7 0.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03319.1 - 1.3e-08 34.8 14.6 2.5e-08 33.9 14.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 EFX03319.1 - 0.53 9.9 15.2 1.2 8.7 15.2 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 EFX03319.1 - 2.8 7.8 20.2 4.6 7.1 20.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pterin_4a PF01329.19 EFX03320.1 - 8.7e-24 83.5 0.1 1.2e-23 83.1 0.1 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase CAP_N PF01213.19 EFX03321.1 - 1.4 8.4 19.7 2.7 7.4 3.7 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EFX03321.1 - 1.6 8.8 23.0 4.9 7.2 4.8 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 adh_short PF00106.25 EFX03322.1 - 3.2e-15 56.1 1.7 9.2e-11 41.6 0.0 3.2 3 0 0 3 3 3 2 short chain dehydrogenase KR PF08659.10 EFX03322.1 - 9.8e-07 28.9 0.0 9.8e-07 28.9 0.0 2.3 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EFX03322.1 - 3.3e-05 23.5 2.5 0.0012 18.4 0.0 3.1 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase E1-N PF14463.6 EFX03322.1 - 0.012 15.5 0.2 0.012 15.5 0.2 2.2 2 0 0 2 2 2 0 E1 N-terminal domain DUF2052 PF09747.9 EFX03322.1 - 4.3 7.4 16.8 6.1 6.9 16.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Fib_alpha PF08702.10 EFX03324.1 - 0.0038 17.4 7.5 0.089 13.0 1.6 3.4 3 0 0 3 3 3 1 Fibrinogen alpha/beta chain family Med21 PF11221.8 EFX03324.1 - 0.021 15.0 3.6 0.021 15.0 3.6 3.9 3 1 1 4 4 4 0 Subunit 21 of Mediator complex SHE3 PF17078.5 EFX03324.1 - 0.081 12.6 19.3 0.26 11.0 6.4 3.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Phage_GP20 PF06810.11 EFX03324.1 - 0.24 11.2 17.0 0.091 12.6 1.7 3.4 1 1 2 3 3 3 0 Phage minor structural protein GP20 Bacillus_HBL PF05791.11 EFX03324.1 - 4.2 7.2 9.1 2.1 8.1 2.1 2.6 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Tropomyosin_1 PF12718.7 EFX03324.1 - 9.6 6.4 27.7 8.7 6.5 12.2 3.0 2 1 1 3 3 3 0 Tropomyosin like PH PF00169.29 EFX03325.1 - 3.5e-05 24.3 0.0 0.0001 22.7 0.0 1.8 2 0 0 2 2 2 1 PH domain Apolipoprotein PF01442.18 EFX03325.1 - 0.0077 16.1 5.4 0.025 14.5 2.0 2.5 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain WXG100 PF06013.12 EFX03325.1 - 0.16 12.2 2.1 3.7 7.9 0.1 2.9 3 0 0 3 3 3 0 Proteins of 100 residues with WXG HeLo PF14479.6 EFX03326.1 - 2.3e-05 24.3 1.3 0.029 14.2 0.1 2.5 1 1 1 2 2 2 2 Prion-inhibition and propagation Bac_rhamnosid_C PF17390.2 EFX03327.1 - 7.3e-12 44.9 0.1 1.5e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 EFX03327.1 - 9.3e-05 21.8 0.0 0.092 12.0 0.0 2.6 2 1 1 3 3 3 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid PF05592.11 EFX03327.1 - 0.0029 17.6 0.0 0.008 16.1 0.0 1.7 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain HU-CCDC81_euk_2 PF18289.1 EFX03327.1 - 0.031 14.4 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 HTH_36 PF13730.6 EFX03327.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Ribonucleas_3_3 PF14622.6 EFX03328.1 - 2.3e-05 24.6 0.0 0.28 11.4 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EFX03328.1 - 0.00014 22.4 0.9 0.00038 21.0 0.9 1.8 1 1 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 EFX03328.1 - 0.00058 20.5 0.0 0.0011 19.6 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Thioredoxin PF00085.20 EFX03329.1 - 3.3e-45 152.3 0.1 3.6e-24 84.7 0.0 3.5 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EFX03329.1 - 1.6e-08 34.6 0.0 0.0061 16.5 0.0 3.8 2 1 2 4 4 4 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFX03329.1 - 1.7e-06 28.3 0.1 0.18 12.1 0.0 3.8 3 1 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFX03329.1 - 1.3e-05 25.6 2.5 0.24 11.9 0.3 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain AhpC-TSA PF00578.21 EFX03329.1 - 2e-05 24.5 1.4 0.13 12.1 0.0 3.8 4 0 0 4 4 4 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EFX03329.1 - 4.8e-05 23.5 0.2 0.09 13.0 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 EFX03329.1 - 0.00029 20.8 2.8 1.4 9.1 0.3 3.9 4 1 0 4 4 4 2 Thioredoxin domain OST3_OST6 PF04756.13 EFX03329.1 - 0.0017 17.8 0.1 1.2 8.4 0.0 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family HyaE PF07449.11 EFX03329.1 - 0.0026 17.7 0.0 1.9 8.5 0.0 3.3 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 EFX03329.1 - 0.0056 16.5 0.0 1.5 8.5 0.0 2.8 3 0 0 3 3 3 1 F plasmid transfer operon protein Calsequestrin PF01216.17 EFX03329.1 - 0.2 10.6 1.5 0.41 9.6 0.2 1.9 2 0 0 2 2 2 0 Calsequestrin DEC-1_N PF04625.13 EFX03329.1 - 9.3 5.1 14.4 0.043 12.8 4.8 1.9 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region Annexin PF00191.20 EFX03330.1 - 1.2e-12 47.7 0.2 0.02 14.9 0.0 4.3 4 0 0 4 4 4 4 Annexin MRP-L27 PF09809.9 EFX03331.1 - 1.7e-15 56.9 1.5 2.1e-15 56.5 1.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Transferase PF02458.15 EFX03332.1 - 2.2e-17 62.9 0.0 3.2e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Transferase family RINGv PF12906.7 EFX03333.1 - 2.6e-17 62.7 8.0 4.2e-17 62.0 8.0 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EFX03333.1 - 0.0065 16.8 8.9 0.011 16.1 8.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EFX03333.1 - 0.17 11.9 2.4 0.4 10.8 2.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EFX03333.1 - 2.5 8.3 4.4 4.5 7.5 4.4 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Mpv17_PMP22 PF04117.12 EFX03333.1 - 5.6 7.3 8.3 0.69 10.2 1.8 2.7 2 0 0 2 2 2 0 Mpv17 / PMP22 family DHBP_synthase PF00926.19 EFX03335.1 - 1.4e-79 266.2 0.1 1.6e-79 266.0 0.1 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase MBA1 PF07961.11 EFX03336.1 - 5.1e-06 25.7 0.0 1e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 MBA1-like protein Tim44 PF04280.15 EFX03336.1 - 0.078 13.1 0.0 0.17 11.9 0.0 1.4 1 1 0 1 1 1 0 Tim44-like domain DEAD PF00270.29 EFX03337.1 - 2.4e-44 151.2 0.0 3.5e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX03337.1 - 1.2e-27 96.5 0.7 7.2e-27 93.9 0.3 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX03337.1 - 1.5e-05 25.1 0.0 2.3e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFX03337.1 - 0.019 14.3 0.0 0.041 13.2 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Transket_pyr PF02779.24 EFX03338.1 - 1e-44 152.3 0.0 1.4e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFX03338.1 - 4.4e-28 97.6 0.0 8e-28 96.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain TyeA PF09059.10 EFX03338.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 TyeA PFOR_II PF17147.4 EFX03338.1 - 0.16 12.3 0.0 0.38 11.1 0.0 1.6 2 0 0 2 2 2 0 Pyruvate:ferredoxin oxidoreductase core domain II Sugar_tr PF00083.24 EFX03339.1 - 9.5e-117 390.6 23.5 1.1e-116 390.4 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03339.1 - 1.6e-20 73.3 34.5 3.2e-17 62.5 26.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1744 PF08490.12 EFX03340.1 - 6.1e-153 509.1 0.0 8.9e-153 508.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EFX03340.1 - 8.7e-77 258.5 0.0 1.4e-76 257.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EFX03340.1 - 5.3e-14 51.8 0.1 1.5e-11 43.7 0.1 3.0 2 1 0 2 2 2 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EFX03340.1 - 7.6e-09 35.6 0.2 1.9e-08 34.3 0.2 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EFX03340.1 - 6.7e-06 26.2 0.0 2.6e-05 24.3 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily Glyco_hydro_18 PF00704.28 EFX03341.1 - 1.7e-84 284.2 0.2 1.9e-84 284.0 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CFEM PF05730.11 EFX03342.1 - 1.2e-09 38.1 11.4 3.2e-09 36.8 11.4 1.8 1 0 0 1 1 1 1 CFEM domain DUF3767 PF12597.8 EFX03343.1 - 1.4e-37 127.6 0.1 1.4e-37 127.6 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) Coilin_N PF15862.5 EFX03343.1 - 0.014 15.2 0.3 0.014 15.2 0.3 1.7 1 1 1 2 2 2 0 Coilin N-terminus DUF5065 PF16723.5 EFX03343.1 - 0.041 13.9 0.0 0.17 12.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5065) Nucleoside_tran PF01733.18 EFX03343.1 - 0.075 12.4 0.0 0.15 11.4 0.0 1.4 1 1 1 2 2 2 0 Nucleoside transporter DoxX_2 PF13564.6 EFX03343.1 - 0.089 12.9 0.3 0.14 12.3 0.3 1.3 1 0 0 1 1 1 0 DoxX-like family Peptidase_S49_N PF08496.10 EFX03343.1 - 0.23 11.5 2.7 0.44 10.6 2.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal U1snRNP70_N PF12220.8 EFX03343.1 - 0.39 11.4 8.5 0.68 10.6 4.9 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal U79_P34 PF03064.16 EFX03343.1 - 9.8 5.5 11.5 15 4.9 11.5 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 VID27 PF08553.10 EFX03344.1 - 2.1e-189 629.0 0.0 2.7e-189 628.7 0.0 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EFX03344.1 - 1e-63 214.3 1.0 1e-63 214.3 1.0 2.8 3 0 0 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 EFX03344.1 - 2.5e-44 150.0 1.1 5.8e-44 148.8 0.4 2.0 2 0 0 2 2 2 1 VID27 PH-like domain UPF0149 PF03695.13 EFX03344.1 - 0.026 14.8 7.1 0.16 12.3 4.9 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) TFB6 PF17110.5 EFX03344.1 - 0.21 11.3 3.9 0.093 12.5 0.4 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CobT PF06213.12 EFX03344.1 - 0.22 10.9 11.6 0.42 10.0 11.6 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 EFX03344.1 - 0.23 11.6 2.3 0.66 10.1 2.3 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 EFX03344.1 - 1.8 6.7 9.9 2.9 6.1 9.9 1.2 1 0 0 1 1 1 0 CDC45-like protein DnaJ PF00226.31 EFX03345.1 - 3.8e-07 30.1 0.6 0.012 15.7 0.0 2.3 2 0 0 2 2 2 2 DnaJ domain AAA PF00004.29 EFX03346.1 - 2e-42 144.7 0.0 3.7e-42 143.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFX03346.1 - 4.8e-29 100.1 0.2 1.8e-28 98.3 0.2 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EFX03346.1 - 9e-23 80.1 4.2 9e-23 80.1 4.2 1.9 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EFX03346.1 - 1.7e-06 27.8 0.1 4.2e-05 23.3 0.0 3.2 4 0 0 4 4 3 1 AAA+ lid domain RNA_helicase PF00910.22 EFX03346.1 - 4e-06 27.2 0.2 0.011 16.1 0.0 3.6 3 0 0 3 3 3 1 RNA helicase RuvB_N PF05496.12 EFX03346.1 - 7.3e-06 25.8 0.0 2e-05 24.4 0.0 1.8 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFX03346.1 - 1.8e-05 25.2 0.0 0.00047 20.6 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EFX03346.1 - 6.2e-05 23.0 0.0 0.00034 20.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFX03346.1 - 6.9e-05 23.1 0.3 0.021 15.1 0.0 2.7 2 1 1 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EFX03346.1 - 8.9e-05 22.3 0.0 0.00023 21.0 0.0 1.6 1 1 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EFX03346.1 - 9.3e-05 21.8 0.0 0.00019 20.8 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EFX03346.1 - 0.00013 21.2 0.0 0.00071 18.8 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EFX03346.1 - 0.00025 21.1 0.0 0.00053 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX03346.1 - 0.00062 20.0 0.0 0.0022 18.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFX03346.1 - 0.001 19.6 0.1 0.0039 17.7 0.0 2.1 2 1 0 2 2 1 1 AAA domain AAA_2 PF07724.14 EFX03346.1 - 0.002 18.3 0.0 0.013 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 EFX03346.1 - 0.0024 17.7 0.0 0.0076 16.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFX03346.1 - 0.006 16.2 0.2 0.5 9.9 0.1 2.6 1 1 1 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EFX03346.1 - 0.014 14.8 0.1 0.08 12.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 EFX03346.1 - 0.015 15.7 0.0 0.05 14.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFX03346.1 - 0.022 14.3 0.1 0.12 11.9 0.0 2.2 2 1 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EFX03346.1 - 0.036 13.1 0.0 0.088 11.9 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Torsin PF06309.11 EFX03346.1 - 0.052 13.6 0.1 0.13 12.4 0.0 1.6 2 0 0 2 2 1 0 Torsin ATPase PF06745.13 EFX03346.1 - 0.056 12.8 0.0 6.9 5.9 0.0 2.3 1 1 1 2 2 2 0 KaiC NACHT PF05729.12 EFX03346.1 - 0.063 13.2 0.0 0.33 10.9 0.0 2.0 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.16 EFX03346.1 - 0.069 12.6 0.1 0.17 11.3 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein Cytidylate_kin PF02224.18 EFX03346.1 - 0.079 12.7 0.2 0.94 9.2 0.1 2.5 2 0 0 2 2 2 0 Cytidylate kinase ATPase_2 PF01637.18 EFX03346.1 - 0.1 12.5 1.4 0.84 9.5 0.0 2.6 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 EFX03346.1 - 0.13 11.9 0.0 0.36 10.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFX03346.1 - 0.15 11.4 0.1 1.5 8.0 0.1 2.3 1 1 1 2 2 2 0 Zeta toxin DUF4398 PF14346.6 EFX03346.1 - 7.9 7.2 6.9 3.1 8.5 1.1 3.1 3 1 1 4 4 2 0 Domain of unknown function (DUF4398) zf-MYND PF01753.18 EFX03347.1 - 8.9e-10 38.5 7.4 8.9e-10 38.5 7.4 2.6 2 0 0 2 2 2 1 MYND finger ATG16 PF08614.11 EFX03348.1 - 3.6e-07 30.6 39.6 0.00032 21.0 17.5 4.6 3 2 0 3 3 3 2 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 EFX03348.1 - 0.0028 17.1 36.2 0.13 11.6 8.9 4.0 2 1 2 4 4 4 3 Domain of unknown function (DUF4407) BMC PF00936.19 EFX03348.1 - 0.0034 17.3 0.6 0.26 11.3 0.4 3.0 2 1 0 2 2 2 1 BMC domain Spc7 PF08317.11 EFX03348.1 - 0.004 16.1 27.1 0.04 12.8 6.6 4.1 3 1 1 4 4 4 2 Spc7 kinetochore protein Fez1 PF06818.15 EFX03348.1 - 0.0055 17.2 23.0 0.39 11.1 3.3 4.0 2 1 2 4 4 4 2 Fez1 NBP1 PF08537.10 EFX03348.1 - 0.013 14.9 0.9 0.039 13.4 0.9 1.7 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 FAM76 PF16046.5 EFX03348.1 - 0.034 13.5 7.3 1.2 8.4 1.1 2.7 2 1 0 2 2 2 0 FAM76 protein FlaC_arch PF05377.11 EFX03348.1 - 0.068 13.6 0.7 21 5.6 0.0 4.2 4 1 0 4 4 3 0 Flagella accessory protein C (FlaC) Rab5-bind PF09311.11 EFX03348.1 - 0.12 11.8 22.5 0.78 9.1 2.8 4.1 3 1 1 4 4 4 0 Rabaptin-like protein KASH_CCD PF14662.6 EFX03348.1 - 0.12 12.2 18.1 0.2 11.5 0.1 4.4 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH TPD52 PF04201.15 EFX03348.1 - 0.22 11.1 0.0 0.22 11.1 0.0 2.6 3 0 0 3 3 2 0 Tumour protein D52 family TMF_DNA_bd PF12329.8 EFX03348.1 - 0.25 11.3 25.3 0.23 11.5 4.9 5.5 5 2 1 6 6 6 0 TATA element modulatory factor 1 DNA binding Filament PF00038.21 EFX03348.1 - 0.26 10.8 29.3 0.59 9.7 7.4 4.4 3 1 0 4 4 4 0 Intermediate filament protein DUF1664 PF07889.12 EFX03348.1 - 0.49 10.4 15.1 5.5 7.1 0.5 4.9 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EFX03348.1 - 0.59 10.8 41.7 1.6 9.4 0.1 8.1 4 3 3 7 7 7 0 SlyX BLOC1_2 PF10046.9 EFX03348.1 - 0.66 10.3 13.6 4.7 7.6 0.0 4.7 5 1 1 6 6 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF641 PF04859.12 EFX03348.1 - 0.76 10.1 18.3 3.3 8.1 0.2 4.5 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) HMMR_N PF15905.5 EFX03348.1 - 0.88 9.0 16.1 0.65 9.4 1.7 3.4 3 1 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF4200 PF13863.6 EFX03348.1 - 0.98 9.8 21.1 0.22 11.9 0.3 4.2 4 1 0 4 4 3 0 Domain of unknown function (DUF4200) MAD PF05557.13 EFX03348.1 - 1 7.6 21.5 0.023 13.1 5.0 2.7 3 0 0 3 3 3 0 Mitotic checkpoint protein HIP1_clath_bdg PF16515.5 EFX03348.1 - 2 9.1 31.5 1.9 9.1 0.1 5.5 4 1 1 6 6 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HTH_Tnp_Mu_1 PF02316.16 EFX03348.1 - 2.2 8.5 12.6 1.7 8.8 0.1 3.7 4 1 1 5 5 5 0 Mu DNA-binding domain AAA_13 PF13166.6 EFX03348.1 - 2.4 6.7 17.4 10 4.6 6.4 3.8 3 1 0 3 3 3 0 AAA domain HrpB7 PF09486.10 EFX03348.1 - 3.5 8.0 70.2 0.052 13.9 12.9 6.0 3 3 2 5 5 5 0 Bacterial type III secretion protein (HrpB7) OmpH PF03938.14 EFX03348.1 - 3.5 7.9 26.0 2.9 8.2 8.6 3.8 3 1 1 4 4 4 0 Outer membrane protein (OmpH-like) DUF5082 PF16888.5 EFX03348.1 - 5.1 7.4 19.8 9.6 6.5 0.1 4.8 4 2 1 5 5 4 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.10 EFX03348.1 - 6.1 7.0 7.1 46 4.2 1.1 3.8 3 1 0 4 4 4 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 EFX03348.1 - 7.2 6.4 15.0 0.58 10.0 1.6 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF724) Wtap PF17098.5 EFX03348.1 - 8.9 6.2 18.6 4 7.4 2.3 5.2 2 1 1 4 4 4 0 WTAP/Mum2p family PBP PF01161.20 EFX03350.1 - 0.0016 18.7 0.0 0.0017 18.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein TFA2_Winged_2 PF18121.1 EFX03351.1 - 1.5e-23 82.3 0.1 3.3e-23 81.1 0.1 1.6 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EFX03351.1 - 6.6e-08 32.7 0.0 3.1e-07 30.6 0.0 2.2 2 1 0 2 2 2 1 TFIIE beta subunit core domain Cpn60_TCP1 PF00118.24 EFX03352.1 - 8.4e-164 545.8 1.0 9.5e-164 545.6 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_UL6 PF01763.16 EFX03352.1 - 0.034 12.7 0.0 0.05 12.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like zf-H2C2 PF09337.10 EFX03353.1 - 6.8e-16 58.2 3.8 1.8e-15 56.9 3.8 1.8 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EFX03353.1 - 5.9e-11 42.3 0.3 5.9e-11 42.3 0.3 2.8 3 0 0 3 3 3 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EFX03353.1 - 0.00075 19.7 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EFX03353.1 - 0.0059 16.8 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFX03353.1 - 0.098 13.3 0.0 0.23 12.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF2263 PF10021.9 EFX03354.1 - 1.9e-10 41.3 0.0 3.5e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Chorion_2 PF03964.15 EFX03354.1 - 0.0069 17.2 5.1 0.0069 17.2 5.1 3.0 3 0 0 3 3 3 1 Chorion family 2 MID_MedPIWI PF18296.1 EFX03354.1 - 0.01 15.6 0.7 0.017 14.9 0.7 1.3 1 0 0 1 1 1 0 MID domain of medPIWI Secretin_N_2 PF07655.13 EFX03354.1 - 0.02 15.4 10.5 0.02 15.4 10.5 1.7 2 0 0 2 2 2 0 Secretin N-terminal domain CCDC106 PF15794.5 EFX03354.1 - 0.32 10.7 6.3 0.55 9.9 6.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CCDC24 PF15669.5 EFX03354.1 - 0.63 9.9 3.8 1.5 8.7 3.7 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family DUF4692 PF15763.5 EFX03354.1 - 0.77 10.2 9.7 1.9 9.0 9.7 1.6 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Apt1 PF10351.9 EFX03354.1 - 4 6.2 10.7 6.1 5.6 10.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Filament_head PF04732.14 EFX03354.1 - 5.8 7.9 30.8 3.5 8.6 0.9 2.6 3 0 0 3 3 3 0 Intermediate filament head (DNA binding) region Lin-8 PF03353.15 EFX03354.1 - 7 6.1 6.2 10 5.6 4.1 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist tRNA-synt_2 PF00152.20 EFX03355.1 - 2e-74 250.5 0.0 2.4e-74 250.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFX03355.1 - 3.7e-05 23.6 0.0 5.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4452 PF14618.6 EFX03355.1 - 0.11 12.4 4.1 0.21 11.4 4.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) WSC PF01822.19 EFX03356.1 - 8.4e-11 41.9 13.9 8.4e-11 41.9 13.9 2.3 2 0 0 2 2 2 1 WSC domain SKG6 PF08693.10 EFX03356.1 - 3.9e-07 29.4 4.0 3.9e-07 29.4 4.0 2.0 2 0 0 2 2 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EFX03356.1 - 0.00087 19.1 0.1 0.0012 18.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Podoplanin PF05808.11 EFX03356.1 - 0.00089 19.4 3.3 0.0018 18.4 3.3 1.6 1 0 0 1 1 1 1 Podoplanin DUF5305 PF17231.2 EFX03356.1 - 0.013 14.9 1.0 0.021 14.2 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF4366 PF14283.6 EFX03356.1 - 0.014 15.5 0.3 0.014 15.5 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Amnionless PF14828.6 EFX03356.1 - 0.02 13.8 0.5 0.037 12.9 0.5 1.4 1 0 0 1 1 1 0 Amnionless DUF3042 PF11240.8 EFX03356.1 - 0.034 14.2 0.1 0.034 14.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) Nitrate_red_gam PF02665.14 EFX03356.1 - 0.053 13.1 0.1 0.085 12.4 0.1 1.3 1 0 0 1 1 1 0 Nitrate reductase gamma subunit V4R PF02830.18 EFX03356.1 - 0.055 13.5 1.2 0.21 11.6 0.0 2.5 3 0 0 3 3 3 0 V4R domain DUF515 PF04415.12 EFX03356.1 - 0.084 11.3 11.5 0.13 10.6 11.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF5308 PF17233.2 EFX03356.1 - 0.33 11.2 11.7 2.5 8.3 11.7 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5308) TMEM154 PF15102.6 EFX03356.1 - 1.1 9.2 5.0 0.17 11.8 1.2 1.5 2 0 0 2 2 2 0 TMEM154 protein family Macoilin PF09726.9 EFX03356.1 - 1.6 7.2 4.1 2.1 6.8 4.1 1.2 1 0 0 1 1 1 0 Macoilin family Pap_E4 PF02711.14 EFX03356.1 - 7.9 7.5 7.8 1.5 9.9 3.1 2.3 2 0 0 2 2 2 0 E4 protein PIP5K PF01504.18 EFX03358.1 - 6e-102 340.6 0.1 9.9e-102 339.8 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cu-oxidase PF00394.22 EFX03359.1 - 3.4e-33 115.0 0.0 5.7e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX03359.1 - 1.2e-23 83.4 0.9 4.2e-23 81.6 0.4 2.2 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFX03359.1 - 0.00033 20.7 3.9 0.068 13.2 0.1 4.2 3 1 1 4 4 4 1 Multicopper oxidase MFS_1 PF07690.16 EFX03361.1 - 4.2e-40 137.8 57.0 4.2e-30 104.9 29.0 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Arginase PF00491.21 EFX03362.1 - 6.5e-73 245.6 0.1 7.7e-73 245.4 0.1 1.0 1 0 0 1 1 1 1 Arginase family COX6B PF02297.17 EFX03363.1 - 7.1e-18 64.6 0.3 8.8e-18 64.3 0.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb SMC_N PF02463.19 EFX03364.1 - 2e-76 256.3 0.0 4.8e-76 255.0 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFX03364.1 - 1.2e-23 83.6 0.0 4.5e-23 81.8 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EFX03364.1 - 9.2e-13 48.7 0.6 4.8e-05 23.3 0.6 3.2 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFX03364.1 - 3.5e-07 30.3 3.6 3.5e-07 30.3 3.6 3.3 2 1 0 2 2 2 1 AAA ATPase domain Tektin PF03148.14 EFX03364.1 - 3.6e-06 26.0 6.1 3.6e-06 26.0 6.1 6.1 3 2 3 6 6 6 2 Tektin family AAA_29 PF13555.6 EFX03364.1 - 0.00077 19.2 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATG16 PF08614.11 EFX03364.1 - 0.0012 19.1 9.7 0.0012 19.1 9.7 9.2 4 2 4 8 8 8 3 Autophagy protein 16 (ATG16) ABC_tran PF00005.27 EFX03364.1 - 2.6 8.5 21.7 3.5 8.1 0.0 6.4 4 2 0 4 4 4 0 ABC transporter PH PF00169.29 EFX03365.1 - 0.00013 22.4 0.1 0.00026 21.5 0.1 1.5 1 0 0 1 1 1 1 PH domain Prominin PF05478.11 EFX03365.1 - 0.006 14.6 0.4 0.0089 14.0 0.4 1.1 1 0 0 1 1 1 1 Prominin Baculo_PEP_C PF04513.12 EFX03365.1 - 0.15 12.1 0.7 0.4 10.7 0.7 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tup_N PF08581.10 EFX03365.1 - 0.22 11.9 3.8 3 8.2 0.1 3.1 3 0 0 3 3 3 0 Tup N-terminal RRF PF01765.19 EFX03365.1 - 0.46 10.4 2.3 0.86 9.5 2.3 1.4 1 0 0 1 1 1 0 Ribosome recycling factor Linker_histone PF00538.19 EFX03366.1 - 1.7e-27 95.6 1.2 2.3e-27 95.2 0.1 1.8 2 0 0 2 2 2 1 linker histone H1 and H5 family Adaptin_N PF01602.20 EFX03367.1 - 3.8e-138 461.3 6.2 5.3e-138 460.8 6.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFX03367.1 - 6.7e-63 211.6 4.4 8.8e-61 204.7 0.1 2.9 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFX03367.1 - 4e-16 59.2 0.2 5.5e-08 33.1 0.0 5.0 1 1 6 7 7 7 4 HEAT repeats HEAT PF02985.22 EFX03367.1 - 1.5e-10 40.4 3.0 0.024 14.9 0.0 5.6 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 EFX03367.1 - 0.00023 21.6 0.1 0.66 10.6 0.0 4.3 3 1 1 4 4 4 1 HEAT-like repeat Arm PF00514.23 EFX03367.1 - 0.016 15.3 1.3 6.9 6.9 0.0 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EFX03367.1 - 0.024 14.2 0.1 1.7 8.2 0.0 3.2 2 1 1 3 3 3 0 CLASP N terminal UNC45-central PF11701.8 EFX03367.1 - 0.037 14.0 0.2 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central PDT PF00800.18 EFX03367.1 - 0.25 11.1 1.5 0.36 10.6 0.2 1.8 2 0 0 2 2 2 0 Prephenate dehydratase CAAP1 PF15335.6 EFX03367.1 - 1.1 9.8 3.2 0.74 10.4 0.1 2.3 3 0 0 3 3 3 0 Caspase activity and apoptosis inhibitor 1 Ribosomal_S27 PF01599.19 EFX03368.1 - 3.5e-27 94.3 1.8 3.5e-27 94.3 1.8 1.7 2 0 0 2 2 2 1 Ribosomal protein S27a Fer2_3 PF13085.6 EFX03368.1 - 0.087 12.8 0.9 0.14 12.1 0.9 1.4 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Prenylcys_lyase PF07156.14 EFX03369.1 - 3.4e-82 276.5 0.4 4.5e-82 276.1 0.4 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 EFX03369.1 - 1.1e-13 51.2 0.0 2.3e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EFX03369.1 - 1.8e-10 40.7 0.0 3e-10 40.0 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EFX03369.1 - 6.5e-06 26.0 0.5 2e-05 24.3 0.5 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX03369.1 - 0.00065 19.0 0.1 0.0078 15.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX03369.1 - 0.0032 17.5 0.0 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding MCRA PF06100.11 EFX03369.1 - 0.013 14.3 0.2 3.8 6.2 0.0 2.2 2 0 0 2 2 2 0 MCRA family Thi4 PF01946.17 EFX03369.1 - 0.12 11.6 0.2 0.2 10.8 0.2 1.3 1 0 0 1 1 1 0 Thi4 family GMC_oxred_N PF00732.19 EFX03370.1 - 2e-52 178.4 0.2 2.6e-52 178.1 0.2 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX03370.1 - 5.3e-35 121.1 0.0 9.8e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EFX03370.1 - 9.9e-05 22.1 1.3 0.0016 18.1 1.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFX03370.1 - 0.00046 19.3 0.3 0.00077 18.6 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EFX03370.1 - 0.00063 19.1 0.7 0.0064 15.8 0.4 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX03370.1 - 0.01 16.1 0.6 0.035 14.3 0.6 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFX03370.1 - 0.041 12.6 0.3 1 8.0 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 EFX03370.1 - 0.22 10.7 0.9 1.5 8.0 0.7 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Gar1 PF04410.14 EFX03371.1 - 2.9e-37 127.8 0.0 3.6e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region FoP_duplication PF13865.6 EFX03371.1 - 5.8 7.5 8.6 1.9 9.1 1.8 2.1 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 ESCRT-II PF05871.12 EFX03374.1 - 9e-51 171.8 0.0 1.4e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 ESCRT-II complex subunit PDCD2_C PF04194.13 EFX03374.1 - 2.9e-43 148.0 0.0 2.9e-43 148.0 0.0 2.9 4 0 0 4 4 4 1 Programmed cell death protein 2, C-terminal putative domain Clathrin PF00637.20 EFX03376.1 - 2e-21 76.4 0.9 4.9e-20 71.9 0.2 2.4 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EFX03376.1 - 0.016 15.4 0.3 0.3 11.4 0.1 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 zf-RING_11 PF17123.5 EFX03376.1 - 0.061 13.1 0.4 0.16 11.8 0.4 1.7 1 0 0 1 1 1 0 RING-like zinc finger DDHD PF02862.17 EFX03376.1 - 0.56 10.3 5.5 1.6 8.9 3.8 2.4 2 0 0 2 2 2 0 DDHD domain CDC45 PF02724.14 EFX03376.1 - 2.9 6.1 25.9 6.5 4.9 25.9 1.6 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFX03376.1 - 3.2 5.8 43.2 5 5.2 43.2 1.2 1 0 0 1 1 1 0 Nop14-like family RTT107_BRCT_5 PF16770.5 EFX03377.1 - 1.2e-32 111.7 0.0 2.8e-30 104.1 0.0 3.7 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 EFX03377.1 - 5.2e-29 100.0 0.2 6.5e-18 64.4 0.1 4.4 4 0 0 4 4 4 3 twin BRCT domain BRCT_2 PF16589.5 EFX03377.1 - 5.5e-20 71.6 0.0 0.00031 21.1 0.0 6.2 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFX03377.1 - 1.1e-19 70.5 0.0 3.7e-05 24.0 0.0 5.9 6 0 0 6 6 6 3 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFX03377.1 - 2.5e-10 40.5 0.0 0.02 15.2 0.0 3.8 3 0 0 3 3 3 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EFX03377.1 - 0.0026 17.8 0.0 2.1 8.5 0.0 3.7 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain Acyl-CoA_dh_1 PF00441.24 EFX03379.1 - 7.7e-42 143.0 0.8 1.1e-41 142.5 0.8 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFX03379.1 - 3.9e-21 75.1 0.1 7.3e-21 74.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 EFX03379.1 - 9.3e-20 70.6 0.2 1.8e-19 69.7 0.2 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 EFX03379.1 - 3.7e-19 69.4 0.0 7.4e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFX03379.1 - 3.2e-08 33.9 0.1 5e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain C6 PF01681.17 EFX03379.1 - 0.15 12.6 0.2 1.8 9.2 0.0 2.6 2 1 1 3 3 3 0 C6 domain Glyco_transf_20 PF00982.21 EFX03380.1 - 2.1e-185 617.0 0.0 2.4e-185 616.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 EFX03380.1 - 0.0028 18.1 0.0 0.0053 17.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 PCB_OB PF17092.5 EFX03380.1 - 0.075 13.8 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain Ribosomal_S26e PF01283.19 EFX03381.1 - 3e-52 175.6 9.5 3.5e-52 175.4 9.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EFX03381.1 - 0.032 14.2 1.4 0.053 13.5 0.0 2.0 3 0 0 3 3 3 0 Zinc binding domain DUF4668 PF15701.5 EFX03381.1 - 0.061 13.1 0.6 0.12 12.2 0.6 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4668) Q_salvage PF10343.9 EFX03381.1 - 0.1 12.2 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family ELYS PF13934.6 EFX03382.1 - 2.8e-67 226.9 0.7 3.3e-67 226.7 0.7 1.0 1 0 0 1 1 1 1 Nuclear pore complex assembly HET PF06985.11 EFX03383.1 - 3e-16 60.1 0.0 8e-16 58.7 0.0 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Lactamase_B_6 PF16661.5 EFX03384.1 - 1.3e-58 197.7 0.0 2.1e-58 196.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EFX03384.1 - 5.7e-49 166.6 1.4 1.8e-46 158.4 0.0 2.8 3 0 0 3 3 3 2 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EFX03384.1 - 2.4e-14 53.5 0.0 8.6e-14 51.8 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EFX03384.1 - 7.4e-07 29.0 0.0 2.2e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EFX03384.1 - 0.0051 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFX03384.1 - 0.0087 16.1 0.0 0.03 14.3 0.0 1.9 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily CN_hydrolase PF00795.22 EFX03385.1 - 4.5e-38 131.1 0.0 5.4e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Nop PF01798.18 EFX03386.1 - 6.5e-84 281.0 0.1 6.5e-84 281.0 0.1 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFX03386.1 - 1.5e-18 66.9 2.7 1.8e-17 63.4 0.0 3.1 3 0 0 3 3 3 1 NOP5NT (NUC127) domain DUF1993 PF09351.10 EFX03387.1 - 1e-30 107.0 0.0 1.2e-30 106.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) JAB PF01398.21 EFX03389.1 - 1.1e-12 47.9 0.0 1.9e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EFX03389.1 - 0.0004 20.1 0.1 0.00095 18.9 0.1 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain USP8_dimer PF08969.11 EFX03389.1 - 0.0077 16.4 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 USP8 dimerisation domain Cpn60_TCP1 PF00118.24 EFX03390.1 - 2.9e-152 507.7 3.7 3.4e-152 507.5 3.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rep_fac_C PF08542.11 EFX03390.1 - 0.012 16.0 0.0 7.2 7.1 0.0 2.8 2 0 0 2 2 2 0 Replication factor C C-terminal domain zf-H2C2_2 PF13465.6 EFX03391.1 - 3.8e-07 30.2 11.4 0.0022 18.3 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFX03391.1 - 6.9e-06 26.2 29.3 0.00034 20.9 7.0 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX03391.1 - 0.00084 20.0 24.8 0.013 16.3 6.0 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EFX03391.1 - 0.002 17.9 7.1 0.16 11.7 2.6 2.5 2 0 0 2 2 2 2 zinc-finger C2H2-type AT_hook PF02178.19 EFX03391.1 - 0.75 9.9 4.5 2.4 8.3 4.5 1.9 1 0 0 1 1 1 0 AT hook motif Zn_ribbon_SprT PF17283.2 EFX03391.1 - 5.3 7.0 9.6 12 5.9 7.0 2.4 1 1 1 2 2 2 0 SprT-like zinc ribbon domain eIF3_N PF09440.10 EFX03392.1 - 8.4e-47 158.9 1.8 8.4e-47 158.9 1.8 1.8 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EFX03392.1 - 2.6e-13 50.4 0.0 1.2e-12 48.3 0.0 2.1 2 0 0 2 2 2 1 PCI domain RPN7 PF10602.9 EFX03392.1 - 0.028 14.2 0.1 0.074 12.8 0.1 1.7 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Sec23_trunk PF04811.15 EFX03393.1 - 2.3e-52 178.0 0.0 5.8e-52 176.7 0.0 1.6 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EFX03393.1 - 2.6e-23 81.8 0.0 4.5e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EFX03393.1 - 5e-18 65.6 0.0 8.9e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFX03393.1 - 5e-14 52.1 4.4 1.1e-13 51.0 4.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFX03393.1 - 0.00017 21.4 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-FPG_IleRS PF06827.14 EFX03393.1 - 2.2 8.2 4.4 48 3.9 3.1 2.6 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-C2H2 PF00096.26 EFX03394.1 - 4.7e-23 80.3 25.0 1.1e-05 25.6 1.6 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFX03394.1 - 5.1e-19 67.8 27.8 5.1e-06 26.7 1.2 5.3 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFX03394.1 - 7e-12 45.1 26.3 0.0017 19.1 1.4 5.2 6 0 0 6 6 4 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EFX03394.1 - 1.1e-05 25.1 6.9 0.00039 20.1 0.4 3.4 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EFX03394.1 - 1.9e-05 24.8 0.8 4.4 7.7 0.0 4.8 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 EFX03394.1 - 0.0024 17.4 2.7 0.43 10.2 0.3 3.0 3 0 0 3 3 2 2 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 EFX03394.1 - 0.028 14.8 13.3 2 8.9 0.0 4.3 5 0 0 5 5 4 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EFX03394.1 - 0.037 14.7 0.8 11 6.7 0.2 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EFX03394.1 - 0.045 13.9 1.2 3.3 7.8 0.1 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2HC_2 PF13913.6 EFX03394.1 - 0.086 12.8 8.1 4.2 7.4 0.2 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-TRAF PF02176.18 EFX03394.1 - 0.35 11.6 8.7 0.8 10.4 0.4 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger IBR PF01485.21 EFX03394.1 - 2.2 8.6 8.2 10 6.5 0.8 3.0 1 1 1 3 3 3 0 IBR domain, a half RING-finger domain zf-CRD PF17979.1 EFX03394.1 - 2.5 8.2 6.6 6.5 6.8 1.8 2.2 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions DUF2256 PF10013.9 EFX03394.1 - 2.8 8.1 7.5 25 5.1 0.0 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn-ribbon_8 PF09723.10 EFX03394.1 - 4.9 7.4 10.4 22 5.3 2.4 3.2 1 1 4 5 5 5 0 Zinc ribbon domain XPA_N PF01286.18 EFX03394.1 - 5.2 7.2 8.6 0.82 9.8 0.7 3.1 4 0 0 4 4 3 0 XPA protein N-terminal DZR PF12773.7 EFX03394.1 - 8.9 6.4 8.6 3.4e+02 1.3 8.6 2.4 1 1 0 1 1 1 0 Double zinc ribbon CBS PF00571.28 EFX03395.1 - 3.8e-35 120.1 4.0 4.9e-09 36.5 0.0 5.1 5 0 0 5 5 5 4 CBS domain PB1 PF00564.24 EFX03395.1 - 3e-08 33.5 0.1 3e-08 33.5 0.1 2.0 2 1 0 2 2 2 1 PB1 domain ANAPC1 PF12859.7 EFX03396.1 - 1.1e-35 123.0 1.5 4.8e-35 120.9 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EFX03396.1 - 0.0095 16.3 0.9 2.8 8.5 0.0 3.9 4 0 0 4 4 4 1 Proteasome/cyclosome repeat SYS1 PF09801.9 EFX03397.1 - 3.9e-49 166.5 8.8 4.6e-49 166.3 8.8 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Androgen_recep PF02166.16 EFX03397.1 - 0.065 12.1 3.1 0.086 11.7 3.1 1.1 1 0 0 1 1 1 0 Androgen receptor FUSC-like PF12805.7 EFX03397.1 - 8.9 5.3 9.8 0.36 9.9 0.6 2.3 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS MFS_1 PF07690.16 EFX03398.1 - 1.1e-30 106.8 30.1 1.3e-30 106.5 29.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily XPG_I PF00867.18 EFX03398.1 - 2.5e-29 101.5 0.0 2.5e-29 101.5 0.0 1.9 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EFX03398.1 - 4.5e-18 65.6 0.0 1.3e-17 64.1 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EFX03398.1 - 6.4e-05 23.5 0.7 0.00017 22.1 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HXXSHH PF07586.11 EFX03398.1 - 0.27 10.8 4.1 0.45 10.0 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) DUF2681 PF10883.8 EFX03398.1 - 10 6.6 7.5 10 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Ribosomal_S2 PF00318.20 EFX03399.1 - 3e-61 206.4 0.5 2.1e-59 200.4 0.5 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 LDcluster4 PF18306.1 EFX03399.1 - 0.11 12.1 0.1 0.24 11.0 0.1 1.5 1 0 0 1 1 1 0 SLOG cluster4 family Abhydrolase_6 PF12697.7 EFX03400.1 - 1.3e-12 48.8 11.1 2.6e-12 47.8 11.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX03400.1 - 1.1e-07 31.3 0.0 1.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFX03400.1 - 3.6e-07 30.1 0.0 8.6e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 EFX03400.1 - 0.041 13.5 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.14 EFX03400.1 - 0.076 11.7 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family DnaJ PF00226.31 EFX03401.1 - 2.6e-20 72.3 0.2 6.3e-20 71.1 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Gryzun PF07919.12 EFX03402.1 - 6.7e-181 603.1 0.0 1e-180 602.4 0.0 1.2 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EFX03402.1 - 1.1e-66 225.1 0.1 3.5e-62 210.3 0.1 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun-like PF12742.7 EFX03402.1 - 0.0028 17.6 0.0 0.0054 16.7 0.0 1.4 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking CENP-B_dimeris PF09026.10 EFX03402.1 - 4.6 7.7 7.9 17 5.9 0.0 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Gti1_Pac2 PF09729.9 EFX03404.1 - 2e-41 142.1 11.1 2.9e-36 125.3 0.1 3.1 2 2 1 3 3 3 2 Gti1/Pac2 family F-actin_cap_A PF01267.17 EFX03405.1 - 5.5e-95 317.8 0.0 6.2e-95 317.6 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CdiI_2 PF18593.1 EFX03405.1 - 0.0077 16.9 0.0 1 10.1 0.0 2.5 2 0 0 2 2 2 2 CdiI immunity protein GatB_N PF02934.15 EFX03406.1 - 4.1e-87 292.0 0.0 5.4e-87 291.7 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EFX03406.1 - 0.00016 21.5 0.0 0.00035 20.5 0.0 1.6 1 0 0 1 1 1 1 GatB domain CFEM PF05730.11 EFX03410.1 - 2.5e-07 30.7 8.9 4.2e-07 30.0 8.9 1.4 1 0 0 1 1 1 1 CFEM domain Ustilago_mating PF05722.12 EFX03410.1 - 0.0027 17.3 5.0 0.0027 17.3 5.0 1.8 2 0 0 2 2 2 1 Ustilago B locus mating-type protein RP-C PF03428.13 EFX03411.1 - 0.038 13.7 4.2 0.066 12.9 4.2 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain Claudin_2 PF13903.6 EFX03412.1 - 0.018 14.8 0.3 0.018 14.8 0.3 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction HUN PF08729.10 EFX03413.1 - 2.5e-07 30.6 0.5 5.3e-07 29.5 0.5 1.5 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Cyt-b5 PF00173.28 EFX03414.1 - 3.5e-23 81.5 0.1 4.7e-23 81.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain p450 PF00067.22 EFX03415.1 - 2.3e-54 184.9 0.0 1e-53 182.7 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 RPAP1_C PF08620.10 EFX03416.1 - 2.9e-28 97.8 0.0 7.4e-28 96.5 0.0 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EFX03416.1 - 2.2e-16 59.3 5.7 2.2e-16 59.3 5.7 1.6 2 0 0 2 2 2 1 RPAP1-like, N-terminal RXT2_N PF08595.11 EFX03417.1 - 1e-45 155.5 0.1 4.6e-45 153.4 0.0 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal Tubulin PF00091.25 EFX03418.1 - 1.2e-70 237.8 0.1 5.2e-70 235.7 0.0 1.9 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFX03418.1 - 3.6e-42 143.5 0.1 6e-42 142.8 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFX03418.1 - 5.8e-06 26.6 0.0 1.4e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFX03418.1 - 0.00051 19.8 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EFX03418.1 - 0.00088 18.6 0.1 0.0027 17.0 0.0 1.7 2 0 0 2 2 2 1 Tubulin like Methyltransf_23 PF13489.6 EFX03419.1 - 2.3e-18 66.5 0.0 3.3e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03419.1 - 1.9e-13 50.9 0.0 3.8e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03419.1 - 2e-13 50.9 0.0 5.6e-13 49.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03419.1 - 2.5e-08 34.6 0.0 2.4e-07 31.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03419.1 - 1.8e-07 31.0 0.0 0.0056 16.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EFX03419.1 - 6e-07 29.0 0.0 6.7e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFX03419.1 - 9.3e-05 22.0 0.0 0.00079 19.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX03419.1 - 0.0039 16.7 0.0 0.01 15.3 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_PK PF05891.12 EFX03419.1 - 0.015 14.8 0.1 0.032 13.7 0.0 1.5 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 EFX03419.1 - 0.058 13.1 0.0 0.14 11.8 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase DUF4037 PF13228.6 EFX03419.1 - 0.07 13.9 0.0 0.12 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4037) Sugar_tr PF00083.24 EFX03420.1 - 3.9e-15 55.7 0.5 5.2e-15 55.3 0.5 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03420.1 - 0.029 13.3 0.8 0.057 12.3 0.7 1.5 2 0 0 2 2 2 0 Major Facilitator Superfamily zf-RING_2 PF13639.6 EFX03421.1 - 1.3e-10 41.4 4.1 2.4e-10 40.6 4.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFX03421.1 - 1.2e-09 38.3 3.3 2.1e-09 37.5 3.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFX03421.1 - 1.1e-06 28.6 0.8 2.1e-06 27.7 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EFX03421.1 - 2.6e-05 24.0 6.7 7.3e-05 22.5 6.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX03421.1 - 5e-05 23.1 3.5 8.3e-05 22.4 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX03421.1 - 8.8e-05 22.4 2.5 0.00015 21.6 2.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFX03421.1 - 0.00018 21.3 2.2 0.00038 20.2 2.2 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX03421.1 - 0.002 17.9 3.4 0.004 17.0 3.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFX03421.1 - 0.0024 17.9 4.8 0.0058 16.6 4.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EFX03421.1 - 0.005 16.4 1.0 0.01 15.4 1.0 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EFX03421.1 - 0.028 14.6 4.4 0.46 10.7 4.4 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_11 PF17123.5 EFX03421.1 - 0.15 11.8 2.1 0.44 10.3 2.1 1.9 1 1 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 EFX03421.1 - 0.22 11.4 1.6 0.52 10.2 1.6 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 EFX03421.1 - 0.28 11.4 1.6 0.69 10.1 1.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DASH_Dam1 PF08653.10 EFX03422.1 - 4.7e-27 93.6 1.3 4.7e-27 93.6 1.3 1.6 2 0 0 2 2 2 1 DASH complex subunit Dam1 DUF167 PF02594.16 EFX03422.1 - 1.6e-06 28.1 0.3 0.001 19.1 0.1 2.4 1 1 1 2 2 2 2 Uncharacterised ACR, YggU family COG1872 DUF4470 PF14737.6 EFX03424.1 - 1.1e-14 54.3 0.0 2.9e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Mqo PF06039.15 EFX03424.1 - 0.11 11.0 0.1 0.19 10.2 0.1 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) CDH-cyt PF16010.5 EFX03425.1 - 2e-20 73.2 8.3 2e-20 73.2 8.3 1.9 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase DUF2427 PF10348.9 EFX03425.1 - 0.008 16.0 4.5 0.017 14.9 4.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) TMEM126 PF07114.11 EFX03425.1 - 0.019 14.4 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 126 Cytochrom_B561 PF03188.16 EFX03425.1 - 0.084 13.0 9.1 0.21 11.7 9.1 1.7 1 1 0 1 1 1 0 Eukaryotic cytochrome b561 PPR_2 PF13041.6 EFX03426.1 - 0.0043 17.2 0.0 2 8.7 0.0 2.7 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 EFX03426.1 - 0.005 16.9 0.0 0.7 10.0 0.0 2.4 2 0 0 2 2 2 2 Pentatricopeptide repeat domain p450 PF00067.22 EFX03427.1 - 7.7e-67 226.0 0.0 9.5e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Complex1_LYR_2 PF13233.6 EFX03428.1 - 1.9e-18 67.0 0.0 2.7e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EFX03428.1 - 1.2e-10 41.3 0.0 2.5e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 EFX03428.1 - 0.05 14.2 0.0 0.073 13.7 0.0 1.3 1 0 0 1 1 1 0 Complex1_LYR-like Thiamine_BP PF01910.17 EFX03429.1 - 2.3e-30 104.3 0.4 2.7e-30 104.1 0.4 1.0 1 0 0 1 1 1 1 Thiamine-binding protein Polysacc_deac_1 PF01522.21 EFX03429.1 - 0.0023 17.8 0.0 0.0031 17.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Med2 PF11214.8 EFX03429.1 - 0.0053 16.9 0.0 0.0074 16.4 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 2 Retro_M PF02813.14 EFX03429.1 - 0.11 13.0 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Retroviral M domain UQ_con PF00179.26 EFX03430.1 - 2.5e-37 127.6 0.0 3.4e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX03430.1 - 0.076 12.7 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B SLAC1 PF03595.17 EFX03431.1 - 5.6e-82 275.6 51.9 7.8e-82 275.1 51.9 1.2 1 0 0 1 1 1 1 Voltage-dependent anion channel Wyosine_form PF08608.12 EFX03431.1 - 1.5e-22 79.7 0.0 3.1e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EFX03431.1 - 8e-22 78.4 0.0 1.6e-21 77.4 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EFX03431.1 - 7.5e-07 29.5 0.9 2.3e-06 27.8 0.1 2.3 2 1 0 2 2 2 1 Flavodoxin NDUF_B4 PF07225.12 EFX03432.1 - 0.0063 16.4 0.1 0.0071 16.2 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Methyltransf_23 PF13489.6 EFX03433.1 - 1.6e-13 50.8 0.0 2.1e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03433.1 - 1.8e-10 41.3 0.1 1e-09 39.0 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03433.1 - 9.1e-09 35.9 0.0 1.7e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03433.1 - 2e-07 30.9 0.0 0.0087 15.9 0.0 2.5 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03433.1 - 6.1e-06 26.9 0.0 2.5e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX03433.1 - 0.00043 19.9 0.0 0.00085 18.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EFX03433.1 - 0.0021 17.4 0.0 0.0036 16.6 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 EFX03433.1 - 0.0069 15.9 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 EFX03433.1 - 0.024 14.4 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EFX03433.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase Ca_chan_IQ PF08763.11 EFX03433.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Voltage gated calcium channel IQ domain DNA_pol_E_B PF04042.16 EFX03435.1 - 2.4e-46 157.7 0.0 3.2e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EFX03435.1 - 8.4e-33 113.2 0.0 1.5e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Adeno_PV PF03910.13 EFX03435.1 - 0.1 11.3 0.9 0.25 10.0 0.9 1.6 1 0 0 1 1 1 0 Adenovirus minor core protein PV DUF2755 PF10954.8 EFX03436.1 - 9 6.3 7.8 3.1 7.8 1.9 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF2755) Ribo_biogen_C PF04034.13 EFX03437.1 - 3e-49 166.0 0.0 4.2e-49 165.5 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EFX03437.1 - 3.4e-12 46.0 1.2 7.5e-12 44.9 1.2 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AltA1 PF16541.5 EFX03439.1 - 3.2e-15 57.0 0.7 5.7e-15 56.1 0.2 1.6 1 1 1 2 2 2 1 Alternaria alternata allergen 1 Ammonium_transp PF00909.21 EFX03440.1 - 1.1e-114 383.3 25.6 1.2e-114 383.1 25.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF373 PF04123.13 EFX03440.1 - 0.1 12.0 1.3 0.24 10.8 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF373) MFS_1 PF07690.16 EFX03441.1 - 3.2e-31 108.5 30.7 3.2e-31 108.5 30.7 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily DASH_Dad3 PF08656.10 EFX03441.1 - 2.3e-29 101.3 0.3 3.8e-29 100.6 0.3 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad3 UNC-93 PF05978.16 EFX03441.1 - 0.0039 16.9 1.7 0.01 15.6 1.7 1.6 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Jagunal PF07086.12 EFX03441.1 - 3.5 7.6 5.7 1.1 9.4 1.1 2.4 2 1 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis DUF1011 PF06237.12 EFX03441.1 - 9.8 6.6 9.0 0.78 10.1 1.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1011) Mpv17_PMP22 PF04117.12 EFX03442.1 - 7.1e-22 77.4 0.1 1.2e-21 76.7 0.1 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family adh_short PF00106.25 EFX03443.1 - 2.1e-29 102.4 0.3 2.5e-29 102.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX03443.1 - 7.7e-21 74.7 0.1 1.1e-20 74.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX03443.1 - 3.4e-15 56.4 0.3 5.4e-15 55.7 0.3 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFX03443.1 - 2.3e-05 23.7 0.1 2.9e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.6 EFX03443.1 - 0.041 14.3 0.3 0.12 12.8 0.3 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding LDcluster4 PF18306.1 EFX03443.1 - 0.054 13.1 0.4 0.11 12.1 0.4 1.4 1 0 0 1 1 1 0 SLOG cluster4 family Sacchrp_dh_NADP PF03435.18 EFX03443.1 - 0.25 11.6 1.4 2.7 8.3 0.1 2.2 1 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain N_BRCA1_IG PF16158.5 EFX03444.1 - 3.7e-33 114.3 1.3 8.5e-33 113.1 0.0 2.4 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EFX03444.1 - 9e-19 67.0 49.1 8.9e-07 28.6 2.2 4.5 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 EFX03444.1 - 0.00019 21.7 38.2 0.023 15.0 2.8 4.6 4 0 0 4 4 4 3 C1 domain Baculo_IE-1 PF05290.11 EFX03444.1 - 7.7 6.5 9.3 0.099 12.6 0.3 2.3 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF2052 PF09747.9 EFX03444.1 - 9.1 6.4 15.0 6.3 6.9 6.8 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Pkinase PF00069.25 EFX03445.1 - 2e-42 145.4 0.0 1.9e-41 142.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03445.1 - 8.3e-31 107.2 0.0 1.3e-30 106.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pal1 PF08316.11 EFX03445.1 - 1.5e-09 38.8 0.0 3.9e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Pal1 cell morphology protein Kdo PF06293.14 EFX03445.1 - 0.017 14.5 0.0 0.047 13.0 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family fn3 PF00041.21 EFX03446.1 - 2.4e-10 40.6 0.2 9e-10 38.8 0.2 2.1 1 0 0 1 1 1 1 Fibronectin type III domain TACC_C PF05010.14 EFX03446.1 - 0.001 18.9 38.5 0.002 17.9 38.5 1.4 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal KCT2 PF17818.1 EFX03446.1 - 0.58 10.3 3.4 0.56 10.3 0.1 2.6 2 0 0 2 2 2 0 Keratinocyte-associated gene product AAA_13 PF13166.6 EFX03446.1 - 4.3 5.9 42.3 0.0087 14.8 31.8 1.6 2 0 0 2 2 2 0 AAA domain Borrelia_P83 PF05262.11 EFX03446.1 - 5.6 5.3 31.8 0.023 13.2 22.8 1.5 2 0 0 2 2 2 0 Borrelia P83/100 protein Csm1 PF12539.8 EFX03447.1 - 8e-31 106.5 0.0 1.3e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 DUF5094 PF17015.5 EFX03447.1 - 0.13 12.3 0.0 0.13 12.3 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF5094) DUF2062 PF09835.9 EFX03447.1 - 0.9 9.4 2.3 1.6 8.6 2.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Chal_sti_synt_C PF02797.15 EFX03448.1 - 1.6e-22 80.2 0.0 3.2e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EFX03448.1 - 1.6e-20 73.5 0.2 2.4e-20 72.9 0.2 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain FAE1_CUT1_RppA PF08392.12 EFX03448.1 - 0.00014 21.3 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EFX03448.1 - 0.00015 21.8 0.0 0.00044 20.4 0.0 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 EFX03448.1 - 0.0064 16.3 0.2 0.021 14.7 0.2 1.9 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UDG PF03167.19 EFX03449.1 - 1.3e-18 67.4 0.0 1e-17 64.5 0.0 2.0 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily Glyco_hydro_11 PF00457.17 EFX03450.1 - 1.2e-56 191.2 17.5 1.4e-56 191.0 17.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Syntaxin PF00804.25 EFX03451.1 - 1.2e-20 74.1 7.6 1.2e-20 74.1 7.6 1.6 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 EFX03451.1 - 1.5e-12 47.3 1.2 5.9e-12 45.4 1.2 2.1 1 0 0 1 1 1 1 SNARE domain ETRAMP PF09716.10 EFX03451.1 - 0.0012 18.9 0.0 0.0018 18.3 0.0 1.4 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF4129 PF13559.6 EFX03451.1 - 0.0016 18.7 4.0 0.0059 16.8 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4129) DUF2207 PF09972.9 EFX03451.1 - 0.0032 16.3 0.9 0.029 13.2 0.0 2.0 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) Syntaxin_2 PF14523.6 EFX03451.1 - 0.0047 17.3 6.5 0.0047 17.3 6.5 2.6 2 1 0 2 2 2 1 Syntaxin-like protein PBP1_TM PF14812.6 EFX03451.1 - 0.1 13.0 1.5 0.14 12.5 0.0 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rx_N PF18052.1 EFX03451.1 - 0.12 12.7 7.1 13 6.1 2.0 3.4 3 1 0 3 3 3 0 Rx N-terminal domain DUF5345 PF17280.2 EFX03451.1 - 0.13 12.3 0.7 1.8 8.6 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5345) EzrA PF06160.12 EFX03451.1 - 0.15 10.2 11.4 0.059 11.5 0.8 2.4 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Synaptobrevin PF00957.21 EFX03451.1 - 0.34 10.7 2.2 0.24 11.2 0.2 1.8 2 0 0 2 2 2 0 Synaptobrevin LMBR1 PF04791.16 EFX03451.1 - 0.44 9.4 1.4 0.64 8.9 1.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Focal_AT PF03623.13 EFX03451.1 - 0.88 9.6 6.9 6.4 6.8 0.1 2.8 2 1 1 3 3 3 0 Focal adhesion targeting region Jnk-SapK_ap_N PF09744.9 EFX03451.1 - 1.7 8.8 15.4 4.1 7.6 0.8 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FUSC PF04632.12 EFX03451.1 - 1.8 7.0 10.5 0.46 8.9 5.5 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family Baculo_PEP_C PF04513.12 EFX03451.1 - 3.5 7.6 15.6 6 6.9 3.4 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCU PF04678.13 EFX03451.1 - 4.9 7.2 8.6 0.54 10.3 0.5 2.4 1 1 1 2 2 2 0 Mitochondrial calcium uniporter AAA PF00004.29 EFX03453.1 - 1.8e-38 132.0 0.0 3.5e-38 131.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX03453.1 - 2e-07 30.7 0.0 4.3e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 EFX03453.1 - 8.7e-06 25.8 0.0 1.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX03453.1 - 9.1e-06 26.2 3.4 0.00046 20.6 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFX03453.1 - 1.1e-05 25.4 0.1 0.00015 21.8 0.1 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFX03453.1 - 2.1e-05 24.3 0.0 5e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFX03453.1 - 2.6e-05 24.4 0.0 0.00012 22.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFX03453.1 - 6.9e-05 23.1 0.3 0.004 17.4 0.0 2.9 2 1 1 3 3 2 1 AAA domain TniB PF05621.11 EFX03453.1 - 0.00089 18.7 0.0 1.3 8.3 0.0 2.6 1 1 0 2 2 2 2 Bacterial TniB protein IstB_IS21 PF01695.17 EFX03453.1 - 0.0011 18.8 0.4 0.0022 17.7 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EFX03453.1 - 0.0011 19.3 0.0 0.0041 17.5 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_33 PF13671.6 EFX03453.1 - 0.0013 18.9 1.6 0.0041 17.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFX03453.1 - 0.0016 17.9 1.7 0.0017 17.7 0.1 1.9 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFX03453.1 - 0.0018 18.6 1.3 0.022 15.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFX03453.1 - 0.0019 18.7 0.1 0.0073 16.8 0.0 2.1 3 0 0 3 3 1 1 AAA domain AAA_25 PF13481.6 EFX03453.1 - 0.0027 17.3 0.1 0.026 14.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EFX03453.1 - 0.0044 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain NACHT PF05729.12 EFX03453.1 - 0.0061 16.5 0.8 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 NACHT domain Rad17 PF03215.15 EFX03453.1 - 0.0083 16.1 0.0 0.029 14.3 0.0 1.7 1 1 1 2 2 2 1 Rad17 P-loop domain Sigma54_activat PF00158.26 EFX03453.1 - 0.01 15.6 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFX03453.1 - 0.015 15.8 0.8 0.099 13.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 EFX03453.1 - 0.016 15.0 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFX03453.1 - 0.016 14.4 0.2 0.044 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EFX03453.1 - 0.036 13.1 0.0 0.078 12.1 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EFX03453.1 - 0.041 13.8 0.0 0.22 11.4 0.0 2.0 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFX03453.1 - 0.044 13.3 0.6 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region FAM75 PF14650.6 EFX03453.1 - 0.048 13.2 4.9 0.066 12.7 4.9 1.1 1 0 0 1 1 1 0 FAM75 family Guanylate_kin PF00625.21 EFX03453.1 - 0.052 13.2 1.1 0.74 9.5 0.0 3.1 3 1 1 4 4 4 0 Guanylate kinase TsaE PF02367.17 EFX03453.1 - 0.056 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 EFX03453.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TIP49 PF06068.13 EFX03453.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain KAP_NTPase PF07693.14 EFX03453.1 - 0.17 11.1 0.3 1.2 8.3 0.0 2.3 2 1 1 3 3 3 0 KAP family P-loop domain ATPase PF06745.13 EFX03453.1 - 0.17 11.2 0.1 0.83 8.9 0.0 2.1 2 1 1 3 3 2 0 KaiC AAA_21 PF13304.6 EFX03453.1 - 0.19 11.5 0.1 14 5.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_17 PF13207.6 EFX03453.1 - 0.2 12.1 2.0 0.28 11.6 0.0 2.2 3 0 0 3 3 2 0 AAA domain Med15 PF09606.10 EFX03453.1 - 0.85 8.2 14.1 1.2 7.7 14.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hydin_ADK PF17213.3 EFX03453.1 - 1.7 8.9 10.7 16 5.7 0.1 2.5 3 0 0 3 3 2 0 Hydin Adenylate kinase-like domain Spt20 PF12090.8 EFX03453.1 - 2.2 7.8 16.1 3.6 7.1 16.1 1.2 1 0 0 1 1 1 0 Spt20 family FYDLN_acid PF09538.10 EFX03453.1 - 2.7 8.7 8.9 6.6 7.5 8.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CCDC53 PF10152.9 EFX03453.1 - 3 8.2 6.2 5.9 7.3 6.2 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SUZ PF12752.7 EFX03454.1 - 0.012 16.4 11.7 0.012 16.4 11.7 4.3 5 1 0 5 5 5 0 SUZ domain FAM199X PF15814.5 EFX03454.1 - 0.044 12.8 0.0 0.064 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein family FAM199X CobN-Mg_chel PF02514.16 EFX03454.1 - 0.064 11.0 0.6 0.079 10.7 0.6 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase WD40 PF00400.32 EFX03455.1 - 2.8e-38 129.2 12.6 2.6e-10 40.7 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX03455.1 - 3e-13 49.9 0.7 0.05 13.9 0.0 5.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX03455.1 - 3.4e-08 32.8 0.1 0.33 9.9 0.0 4.2 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFX03455.1 - 0.00012 20.8 3.6 0.34 9.5 0.1 3.9 2 2 0 3 3 3 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EFX03455.1 - 0.00043 19.3 1.4 0.0011 17.9 0.0 2.2 2 0 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EFX03455.1 - 0.0047 15.7 0.1 0.42 9.3 0.0 3.1 1 1 2 4 4 4 1 Nup133 N terminal like HPS3_N PF14761.6 EFX03455.1 - 0.03 13.9 0.0 0.14 11.7 0.0 2.0 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 Frtz PF11768.8 EFX03455.1 - 0.068 11.5 0.0 0.1 10.9 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 EFX03455.1 - 0.14 11.9 1.6 8.5 6.0 0.0 3.4 1 1 3 4 4 4 0 TUP1-like enhancer of split TRAM_LAG1_CLN8 PF03798.16 EFX03456.1 - 8.7e-36 123.5 15.4 8.7e-36 123.5 15.4 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EFX03456.1 - 6.7e-21 73.7 0.0 2e-20 72.2 0.0 1.9 1 0 0 1 1 1 1 TRAM1-like protein OAD_gamma PF04277.13 EFX03457.1 - 0.0058 17.2 0.7 0.0083 16.7 0.3 1.4 2 0 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain PspB PF06667.12 EFX03457.1 - 0.018 15.1 0.3 0.022 14.8 0.3 1.1 1 0 0 1 1 1 0 Phage shock protein B DUF2207 PF09972.9 EFX03457.1 - 0.042 12.6 0.3 0.043 12.6 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ATP-synt_8 PF00895.20 EFX03457.1 - 0.053 14.0 0.2 0.071 13.6 0.2 1.2 1 0 0 1 1 1 0 ATP synthase protein 8 Vpu PF00558.19 EFX03457.1 - 0.087 12.6 0.4 0.11 12.2 0.4 1.2 1 0 0 1 1 1 0 Vpu protein SIT PF15330.6 EFX03457.1 - 0.11 12.9 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT FeoB_associated PF12669.7 EFX03457.1 - 0.27 11.6 0.8 0.41 11.1 0.8 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Lactamase_B PF00753.27 EFX03459.1 - 4.5e-06 26.8 0.1 7.2e-06 26.2 0.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFX03459.1 - 0.0035 16.9 0.0 0.0065 16.0 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PCI PF01399.27 EFX03460.1 - 0.00053 20.5 0.0 0.99 10.0 0.0 2.3 2 0 0 2 2 2 2 PCI domain TPR_2 PF07719.17 EFX03460.1 - 0.13 12.4 0.2 0.37 11.0 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat AA_permease_2 PF13520.6 EFX03461.1 - 3.4e-53 181.0 58.3 4.2e-53 180.7 58.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX03461.1 - 4e-23 81.8 48.8 5.3e-23 81.4 48.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2463 PF09591.10 EFX03461.1 - 0.032 14.1 10.8 0.16 11.8 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2463) COX4 PF02936.14 EFX03461.1 - 0.85 9.6 5.3 0.18 11.8 0.8 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV DUF3638 PF12340.8 EFX03462.1 - 3.2e-97 324.3 0.2 6.8e-97 323.2 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EFX03462.1 - 1.3e-17 62.9 1.0 2.5e-17 61.9 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Zn_clus PF00172.18 EFX03463.1 - 1.3e-05 25.2 14.0 2.1e-05 24.6 14.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF294 PF03445.13 EFX03463.1 - 0.079 12.8 0.8 0.18 11.6 0.8 1.5 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 MARVEL PF01284.23 EFX03464.1 - 6.4e-05 23.0 12.4 0.0013 18.8 11.5 2.1 1 1 1 2 2 2 2 Membrane-associating domain SPA PF08616.10 EFX03464.1 - 0.13 12.2 0.3 1.1 9.2 0.1 2.1 2 0 0 2 2 2 0 Stabilization of polarity axis TssN PF17555.2 EFX03464.1 - 0.23 10.8 2.4 0.36 10.2 2.4 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN Methyltransf_16 PF10294.9 EFX03465.1 - 3.2e-10 40.0 0.3 0.013 15.3 0.0 3.2 2 1 1 3 3 3 3 Lysine methyltransferase SelP_N PF04592.14 EFX03465.1 - 0.037 13.4 4.1 0.053 12.9 4.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region BAT2_N PF07001.11 EFX03466.1 - 5.4 7.4 8.9 2.1 8.8 4.0 2.3 2 0 0 2 2 2 0 BAT2 N-terminus MIT PF04212.18 EFX03468.1 - 5.9e-10 39.1 0.9 1.3e-09 38.0 0.9 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain zf-CCCH_4 PF18044.1 EFX03469.1 - 3.4e-08 33.1 11.6 1.6e-05 24.6 1.3 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFX03469.1 - 4.1e-07 29.8 17.2 6.5e-05 22.8 4.3 3.1 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 EFX03469.1 - 5.6e-07 29.3 9.3 1.3e-05 24.9 1.9 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFX03469.1 - 1.7e-05 25.5 2.4 0.0056 17.4 0.5 2.5 2 0 0 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 EFX03469.1 - 0.00011 22.4 0.5 0.0025 18.0 0.9 2.3 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EFX03469.1 - 0.25 11.9 16.3 0.7 10.5 4.0 3.1 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger CYLD_phos_site PF16607.5 EFX03469.1 - 0.42 10.5 9.7 0.058 13.2 0.6 2.8 2 0 0 2 2 2 0 Phosphorylation region of CYLD, unstructured adh_short PF00106.25 EFX03470.1 - 5.5e-24 84.7 0.0 7.5e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX03470.1 - 1.7e-17 63.8 0.0 2.8e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX03470.1 - 6e-12 45.8 0.1 1.7e-11 44.4 0.0 1.6 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EFX03470.1 - 2.2e-06 27.0 0.0 2.9e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFX03470.1 - 3.1e-06 26.8 0.0 7.8e-06 25.5 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX03470.1 - 0.011 15.2 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase PS-DH PF14765.6 EFX03470.1 - 0.16 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Polyketide synthase dehydratase Fungal_trans PF04082.18 EFX03471.1 - 1.3e-11 44.1 0.0 1.8e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03471.1 - 7.9e-06 25.9 7.2 1.6e-05 25.0 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M28 PF04389.17 EFX03474.1 - 6.9e-37 127.1 0.0 9.7e-37 126.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFX03474.1 - 1.3e-11 44.4 1.0 3e-11 43.2 1.0 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EFX03474.1 - 0.00072 19.3 0.0 0.0015 18.2 0.0 1.7 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PepX_C PF08530.10 EFX03475.1 - 5.1e-43 147.6 0.0 8.4e-43 146.9 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EFX03475.1 - 4.9e-39 134.5 0.7 6.8e-39 134.1 0.7 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 EFX03475.1 - 0.044 13.0 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ank_2 PF12796.7 EFX03477.1 - 7e-77 254.1 15.8 1.6e-15 57.5 0.1 8.5 3 3 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX03477.1 - 1.3e-61 204.2 12.5 4.3e-07 30.4 0.0 11.3 6 3 5 11 11 11 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX03477.1 - 4.2e-60 199.0 26.4 1e-07 32.1 0.0 13.2 6 3 8 14 14 14 13 Ankyrin repeats (many copies) Ank PF00023.30 EFX03477.1 - 5.9e-50 165.6 11.0 8.4e-05 22.8 0.1 15.8 15 0 0 15 15 15 14 Ankyrin repeat Ank_3 PF13606.6 EFX03477.1 - 9.7e-43 139.3 14.3 0.0052 17.2 0.0 16.9 17 1 0 17 17 17 10 Ankyrin repeat HET PF06985.11 EFX03477.1 - 1.3e-19 71.0 0.0 7e-19 68.6 0.0 2.3 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) INSIG PF07281.12 EFX03477.1 - 0.049 13.3 0.1 0.095 12.3 0.1 1.4 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) zf-C2H2 PF00096.26 EFX03478.1 - 2.6e-05 24.4 11.5 0.0041 17.5 3.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type PSI_PsaH PF03244.14 EFX03478.1 - 0.024 14.2 0.2 0.053 13.0 0.2 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI zf-C2H2_aberr PF17017.5 EFX03478.1 - 0.13 12.4 3.6 0.24 11.5 2.5 1.8 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EFX03478.1 - 1 10.4 15.3 0.16 12.9 3.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX03478.1 - 7.8 7.1 12.2 1.4 9.4 0.5 3.6 3 0 0 3 3 3 0 Zinc-finger double domain p450 PF00067.22 EFX03479.1 - 1e-63 215.7 0.0 4.9e-50 170.6 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 FAD_binding_3 PF01494.19 EFX03480.1 - 1.1e-23 84.1 0.1 6.4e-11 42.1 0.3 2.1 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EFX03480.1 - 3.9e-05 22.9 2.0 0.044 12.8 0.2 3.1 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_9 PF13454.6 EFX03480.1 - 0.0064 16.5 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 EFX03480.1 - 0.0067 16.0 0.9 3 7.3 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX03480.1 - 0.0097 15.2 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EFX03480.1 - 0.012 14.7 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase NAD_binding_8 PF13450.6 EFX03480.1 - 0.092 13.0 0.3 0.49 10.7 0.0 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFX03480.1 - 0.25 10.5 0.0 0.38 9.8 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Asparaginase PF00710.20 EFX03481.1 - 2.2e-53 180.7 1.1 3e-53 180.2 1.1 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFX03481.1 - 4.7e-18 65.5 0.3 2.2e-17 63.3 0.0 2.2 2 1 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain NACHT PF05729.12 EFX03482.1 - 1.2e-05 25.3 0.0 2.8e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF676 PF05057.14 EFX03482.1 - 0.0038 16.7 0.0 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Ank_2 PF12796.7 EFX03482.1 - 0.0041 17.7 0.0 0.019 15.5 0.0 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) AAA_22 PF13401.6 EFX03482.1 - 0.0078 16.5 0.0 0.081 13.2 0.0 2.8 3 1 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 EFX03482.1 - 0.021 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EFX03482.1 - 0.029 14.1 0.0 0.074 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EFX03482.1 - 0.032 14.6 0.0 0.43 11.0 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 EFX03482.1 - 0.036 14.5 0.0 0.34 11.3 0.0 2.6 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Ploopntkinase3 PF18751.1 EFX03482.1 - 0.038 13.9 0.0 14 5.6 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 EFX03482.1 - 0.056 13.8 0.0 0.7 10.3 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EFX03482.1 - 0.087 12.0 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Ank_4 PF13637.6 EFX03482.1 - 0.13 12.9 0.3 17 6.1 0.0 3.4 3 1 0 3 3 2 0 Ankyrin repeats (many copies) ABC_tran PF00005.27 EFX03482.1 - 0.13 12.8 0.0 0.36 11.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Ploopntkinase1 PF18748.1 EFX03482.1 - 0.15 11.6 0.0 0.41 10.1 0.0 1.7 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 Sugar_tr PF00083.24 EFX03483.1 - 4.3e-100 335.7 14.3 5.2e-100 335.4 14.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03483.1 - 5.3e-17 61.8 24.5 5.3e-17 61.8 24.5 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily YL1_C PF08265.11 EFX03483.1 - 8.2e-15 54.3 0.3 1.8e-14 53.2 0.3 1.6 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Mif2_N PF15624.6 EFX03483.1 - 0.063 14.0 0.2 0.14 12.9 0.2 1.5 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cwf_Cwc_15 PF04889.12 EFX03484.1 - 5.2e-71 239.3 17.1 7.5e-44 150.3 12.0 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein Pet100 PF09803.9 EFX03484.1 - 2.6 8.6 5.1 5 7.7 4.4 1.8 1 1 0 2 2 2 0 Pet100 SHR3_chaperone PF08229.11 EFX03486.1 - 1.6e-66 222.9 0.2 1.9e-66 222.6 0.2 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Mit_KHE1 PF10173.9 EFX03489.1 - 9e-59 198.8 0.0 1.4e-58 198.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related DUF2334 PF10096.9 EFX03490.1 - 1.1e-12 48.0 0.2 1.4e-12 47.8 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Polysacc_deac_1 PF01522.21 EFX03490.1 - 1.7e-10 40.9 0.0 2.8e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2194 PF09960.9 EFX03490.1 - 0.0053 15.2 0.1 0.0072 14.7 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2194) UCH_1 PF13423.6 EFX03491.1 - 3.6e-97 325.8 0.2 5.2e-97 325.3 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EFX03491.1 - 3.1e-21 76.6 0.0 5.3e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EFX03491.1 - 1.1e-05 25.1 0.0 3.1e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF410 PF04190.13 EFX03491.1 - 0.0013 18.6 0.0 0.0044 16.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF410) AAA_22 PF13401.6 EFX03494.1 - 0.00013 22.2 0.1 0.0012 19.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFX03494.1 - 0.00046 19.5 0.0 0.00065 19.0 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFX03494.1 - 0.0024 18.3 0.1 0.0042 17.5 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EFX03494.1 - 0.0044 16.3 0.0 0.0086 15.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 EFX03494.1 - 0.005 17.4 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 EFX03494.1 - 0.0084 15.9 0.0 0.027 14.2 0.0 1.7 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EFX03494.1 - 0.012 15.8 2.0 0.072 13.3 2.0 2.1 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFX03494.1 - 0.041 13.8 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 EFX03494.1 - 0.047 13.3 0.1 0.088 12.4 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EFX03494.1 - 0.05 12.6 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 EFX03494.1 - 0.063 13.0 0.2 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EFX03494.1 - 0.08 13.4 0.1 0.26 11.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFX03494.1 - 0.086 13.3 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EFX03494.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFX03494.1 - 0.23 11.4 0.1 0.51 10.3 0.0 1.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fungal_trans PF04082.18 EFX03495.1 - 3.1e-15 55.9 0.1 5.9e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03495.1 - 3.6e-07 30.2 7.3 5.9e-07 29.5 7.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Forkhead PF00250.18 EFX03496.1 - 2.1e-13 50.3 0.0 4.3e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EFX03496.1 - 9.3e-05 22.7 0.1 0.00022 21.5 0.1 1.6 1 0 0 1 1 1 1 FHA domain F-box-like PF12937.7 EFX03497.1 - 0.001 18.9 0.1 0.0033 17.3 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX03497.1 - 0.0013 18.6 0.1 0.004 17.0 0.0 1.9 1 1 1 2 2 2 1 F-box domain Ank_5 PF13857.6 EFX03497.1 - 0.014 15.7 0.6 0.031 14.6 0.1 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) ThiF PF00899.21 EFX03498.1 - 2.5e-64 216.9 0.0 3.6e-64 216.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EFX03498.1 - 9.8e-28 96.1 0.0 2e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EFX03498.1 - 0.00053 20.1 0.2 0.0027 17.8 0.1 2.1 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase UAE_UbL PF14732.6 EFX03498.1 - 0.0029 18.2 0.0 0.018 15.6 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Ecm33 PF12454.8 EFX03498.1 - 0.02 15.0 1.1 0.043 14.0 1.1 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein UDPG_MGDP_dh_N PF03721.14 EFX03498.1 - 0.067 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EFX03498.1 - 0.1 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX03499.1 - 1.7e-37 129.8 2.4 2e-37 129.6 2.4 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX03499.1 - 5e-08 33.1 0.1 2e-07 31.1 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX03499.1 - 3.8e-06 26.3 0.1 0.0012 18.2 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX03499.1 - 1.6e-05 24.4 0.7 0.031 13.6 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase GIDA PF01134.22 EFX03499.1 - 7.3e-05 22.0 0.1 0.031 13.3 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EFX03499.1 - 8.7e-05 21.8 2.2 0.00066 18.9 0.8 2.3 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EFX03499.1 - 0.00016 21.0 0.0 0.00029 20.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFX03499.1 - 0.00031 20.1 0.2 0.00054 19.3 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX03499.1 - 0.0012 19.4 0.1 0.0037 17.8 0.0 1.9 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX03499.1 - 0.0098 14.6 0.5 0.17 10.6 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EFX03499.1 - 0.01 15.8 0.9 1.2 9.2 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFX03499.1 - 0.012 14.9 0.1 0.02 14.1 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 EFX03499.1 - 0.012 14.5 0.5 0.022 13.6 0.2 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Ornatin PF02088.15 EFX03499.1 - 0.021 14.6 0.0 0.052 13.3 0.0 1.6 1 0 0 1 1 1 0 Ornatin ThiF PF00899.21 EFX03499.1 - 0.062 12.6 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 ThiF family NAD_binding_7 PF13241.6 EFX03499.1 - 0.065 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 EFX03499.1 - 0.09 12.1 0.5 0.15 11.4 0.5 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EFX03499.1 - 0.2 11.7 0.0 0.42 10.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 EFX03499.1 - 0.24 10.5 0.0 0.98 8.5 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) SecY PF00344.20 EFX03501.1 - 7.5e-72 242.2 7.6 9.5e-72 241.8 7.6 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EFX03501.1 - 1.3e-17 63.3 0.4 4.3e-17 61.6 0.4 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p Pkinase PF00069.25 EFX03504.1 - 8.7e-34 117.1 0.0 1.2e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03504.1 - 1.4e-15 57.3 0.0 2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX03504.1 - 0.035 12.9 0.0 0.051 12.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FAD_binding_4 PF01565.23 EFX03505.1 - 1.6e-25 89.5 0.0 2.7e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain CPL PF08144.11 EFX03506.1 - 1.6e-42 145.3 0.0 1.2e-37 129.4 0.0 3.2 2 1 0 2 2 2 2 CPL (NUC119) domain Velvet PF11754.8 EFX03506.1 - 0.03 14.3 1.8 0.76 9.7 0.0 2.4 2 0 0 2 2 2 0 Velvet factor SCHIP-1 PF10148.9 EFX03506.1 - 8.9 5.9 10.4 0.043 13.4 1.4 1.6 2 0 0 2 2 2 0 Schwannomin-interacting protein 1 Glyco_hydro_16 PF00722.21 EFX03507.1 - 1.4e-10 40.9 0.0 2.8e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TMEM119 PF15724.5 EFX03507.1 - 0.065 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 TMEM119 family VirB8 PF04335.13 EFX03507.1 - 1.6 8.5 4.3 0.45 10.3 0.1 1.9 1 1 1 2 2 2 0 VirB8 protein Ketoacyl-synt_C PF02801.22 EFX03508.1 - 0.13 12.3 0.0 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Methyltransf_23 PF13489.6 EFX03509.1 - 1.7e-22 80.0 0.0 2.4e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03509.1 - 1.2e-11 44.6 0.0 1.2e-10 41.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03509.1 - 3.5e-10 40.5 0.0 7.2e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03509.1 - 6.9e-07 29.8 0.0 1.3e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03509.1 - 9.5e-07 29.5 0.0 5.5e-06 27.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EFX03509.1 - 0.00083 19.1 0.0 0.0023 17.7 0.0 1.6 2 0 0 2 2 2 1 Lysine methyltransferase MTS PF05175.14 EFX03509.1 - 0.004 16.7 0.0 0.0098 15.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EFX03509.1 - 0.005 17.0 0.0 0.0077 16.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.13 EFX03509.1 - 0.017 14.5 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EFX03509.1 - 0.085 12.3 0.0 0.23 10.9 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Response_reg PF00072.24 EFX03510.1 - 2.6e-28 98.4 0.3 4.8e-28 97.6 0.3 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EFX03510.1 - 2.9e-26 92.2 0.4 3.2e-24 85.6 0.4 2.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFX03510.1 - 1e-14 54.3 0.0 2.1e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EFX03510.1 - 0.013 15.8 0.1 0.59 10.6 0.0 3.0 3 0 0 3 3 3 0 HAMP domain B56 PF01603.20 EFX03511.1 - 3.3e-193 642.3 3.4 3.9e-193 642.1 3.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EFX03511.1 - 0.00071 19.5 2.1 0.36 10.7 0.0 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Dynamin_N PF00350.23 EFX03511.1 - 0.11 12.6 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Dynamin family Nup160 PF11715.8 EFX03513.1 - 1.7e-128 429.6 0.0 2.6e-128 429.0 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_7 PF13176.6 EFX03513.1 - 0.016 15.2 0.3 0.096 12.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-AD PF07776.15 EFX03513.1 - 0.12 12.6 0.1 0.36 11.1 0.1 1.8 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) DUF3375 PF11855.8 EFX03514.1 - 0.013 14.5 2.2 0.024 13.6 1.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3375) DUF2205 PF10224.9 EFX03514.1 - 0.25 11.4 2.9 1.3 9.0 0.2 2.6 2 0 0 2 2 2 0 Short coiled-coil protein HSCB_C PF07743.13 EFX03514.1 - 0.39 11.2 3.8 4.7 7.8 0.2 3.2 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Aa_trans PF01490.18 EFX03515.1 - 2.4e-26 92.4 28.8 4.2e-15 55.4 6.0 2.0 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein HgmA PF04209.13 EFX03517.1 - 1.5e-142 475.3 0.0 1.7e-142 475.1 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase ATP-synt_C PF00137.21 EFX03518.1 - 0.014 15.8 1.9 0.038 14.3 1.9 1.7 1 0 0 1 1 1 0 ATP synthase subunit C Otopetrin PF03189.13 EFX03518.1 - 0.14 11.0 0.1 0.21 10.4 0.1 1.3 1 0 0 1 1 1 0 Otopetrin Methyltransf_23 PF13489.6 EFX03519.1 - 1.1e-06 28.6 0.0 1.5e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain STT3 PF02516.14 EFX03520.1 - 3.8e-141 471.4 36.8 5.2e-136 454.4 35.0 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Het-C PF07217.11 EFX03521.1 - 2.2e-281 934.4 0.0 2.8e-281 934.0 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Ribosomal_L37 PF08561.10 EFX03522.1 - 1.6e-41 141.6 0.1 2.4e-41 141.0 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 CAP_N PF01213.19 EFX03522.1 - 0.024 14.1 4.2 0.036 13.6 4.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal LIP PF03583.14 EFX03523.1 - 4.4e-75 252.6 0.3 6.1e-75 252.2 0.3 1.1 1 0 0 1 1 1 1 Secretory lipase Sina PF03145.16 EFX03524.1 - 0.00061 19.8 0.3 0.0014 18.6 0.3 1.5 1 0 0 1 1 1 1 Seven in absentia protein family zf-C2H2_4 PF13894.6 EFX03524.1 - 2 9.5 10.9 17 6.6 0.1 5.1 5 0 0 5 5 5 0 C2H2-type zinc finger Histidinol_dh PF00815.20 EFX03525.1 - 1.3e-135 452.6 0.0 1.5e-135 452.4 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase HlyIII PF03006.20 EFX03526.1 - 5.9e-59 199.5 19.2 7.2e-59 199.2 19.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF2894 PF11445.8 EFX03526.1 - 0.091 13.2 0.7 0.49 10.8 0.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) FerA PF08165.11 EFX03526.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 FerA (NUC095) domain BCDHK_Adom3 PF10436.9 EFX03527.1 - 3.1e-44 150.7 0.0 4.3e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFX03527.1 - 1.1e-11 45.2 0.0 3.5e-10 40.4 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Inhibitor_I9 PF05922.16 EFX03527.1 - 2.2e-07 31.4 0.0 5.1e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 CAP_N PF01213.19 EFX03527.1 - 4.6 6.6 9.2 1.7 8.0 6.1 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal zf-C3HC4_3 PF13920.6 EFX03528.1 - 1.7 8.6 6.9 13 5.7 0.4 3.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) NAD_binding_5 PF07994.12 EFX03529.1 - 1.6e-142 474.6 0.0 1.9e-142 474.4 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EFX03529.1 - 4e-45 152.5 0.2 7.2e-45 151.7 0.2 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase AAA_23 PF13476.6 EFX03530.1 - 3.4e-15 57.1 6.5 5.9e-14 53.0 0.0 2.7 2 1 0 3 3 2 1 AAA domain SMC_N PF02463.19 EFX03530.1 - 3.6e-09 36.4 0.0 8.3e-08 31.9 0.0 2.8 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Metallophos PF00149.28 EFX03530.1 - 3.8e-07 30.8 0.1 9.9e-07 29.5 0.1 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_15 PF13175.6 EFX03530.1 - 2e-05 24.5 2.3 2.3e-05 24.3 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFX03530.1 - 7.5e-05 22.4 0.0 0.0002 21.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 EFX03530.1 - 0.0002 21.5 0.0 0.00079 19.6 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AlkA_N PF06029.11 EFX03530.1 - 0.0013 19.0 0.1 0.0059 16.9 0.1 2.2 1 0 0 1 1 1 1 AlkA N-terminal domain AAA_21 PF13304.6 EFX03530.1 - 0.0017 18.3 0.2 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EFX03530.1 - 0.05 14.1 0.0 0.05 14.1 0.0 3.0 3 1 0 3 3 3 0 ABC transporter AAA_22 PF13401.6 EFX03530.1 - 0.088 13.1 0.3 5.9 7.2 0.0 3.1 2 1 0 2 2 2 0 AAA domain A_deamin PF02137.18 EFX03530.1 - 0.13 11.7 3.2 0.21 11.0 3.2 1.3 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain SAPIS-gp6 PF16722.5 EFX03530.1 - 0.18 12.2 10.6 0.045 14.1 3.0 3.1 3 0 0 3 3 3 0 Pathogenicity island protein gp6 in Staphylococcus AAA_16 PF13191.6 EFX03530.1 - 0.26 11.7 0.0 0.26 11.7 0.0 3.8 4 1 0 4 4 4 0 AAA ATPase domain tRNA-synt_1b PF00579.25 EFX03531.1 - 8.2e-77 258.4 0.0 1.1e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EFX03531.1 - 1.3e-44 150.8 0.0 2.9e-44 149.7 0.0 1.6 2 0 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain Zn_clus PF00172.18 EFX03532.1 - 2.7e-09 37.0 9.9 4.8e-09 36.2 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX03532.1 - 5.5e-07 28.9 0.0 8.4e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 EFX03533.1 - 4e-40 138.0 18.1 6.7e-40 137.3 18.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03533.1 - 2.7e-31 108.8 22.0 2.5e-24 85.9 8.1 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EFX03533.1 - 0.019 13.9 2.9 0.2 10.5 0.5 2.3 2 0 0 2 2 2 0 Sugar-tranasporters, 12 TM CIAPIN1 PF05093.13 EFX03534.1 - 6.7e-42 142.1 2.8 1.3e-41 141.2 2.8 1.5 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EFX03534.1 - 4.5e-35 120.7 0.1 6.6e-35 120.2 0.1 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus Hom_end PF05204.14 EFX03534.1 - 0.09 13.0 0.1 0.23 11.6 0.1 1.7 1 0 0 1 1 1 0 Homing endonuclease Vps55 PF04133.14 EFX03535.1 - 2e-44 150.3 7.0 2.2e-44 150.1 7.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF898 PF05987.13 EFX03535.1 - 7.8 5.4 10.8 0.28 10.2 2.1 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Fip1 PF05182.13 EFX03536.1 - 1.9e-20 72.1 1.2 3e-20 71.4 1.2 1.4 1 0 0 1 1 1 1 Fip1 motif Aldedh PF00171.22 EFX03537.1 - 4.2e-139 464.0 0.0 5.8e-139 463.6 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFX03537.1 - 0.0014 17.8 0.0 0.0029 16.7 0.0 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Kdo PF06293.14 EFX03538.1 - 4.9e-13 48.9 0.0 6.8e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX03538.1 - 6e-10 39.5 4.0 0.0001 22.3 0.7 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EFX03538.1 - 4.3e-09 36.1 0.0 6.6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03538.1 - 1.4e-05 24.5 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX03538.1 - 0.006 15.4 0.0 0.0079 15.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase EcKinase PF02958.20 EFX03538.1 - 0.012 15.0 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase RIO1 PF01163.22 EFX03538.1 - 0.052 13.1 0.0 0.97 9.0 0.0 2.3 2 0 0 2 2 2 0 RIO1 family WD40 PF00400.32 EFX03540.1 - 4.5e-09 36.8 5.4 0.031 15.1 0.1 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.8 EFX03540.1 - 0.14 10.7 0.0 0.24 10.0 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EFX03540.1 - 2.3 8.8 8.0 12 6.5 0.1 4.7 5 1 0 5 5 5 0 PQQ-like domain DUF2207 PF09972.9 EFX03541.1 - 0.0057 15.5 0.0 0.012 14.4 0.0 1.4 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EFX03541.1 - 0.034 15.0 0.0 1.7 9.6 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.6 EFX03541.1 - 0.055 13.7 1.6 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) VPDSG-CTERM PF18205.1 EFX03541.1 - 0.28 11.1 2.7 0.82 9.6 2.7 1.8 1 0 0 1 1 1 0 VPDSG-CTERM motif NR_Repeat PF14046.6 EFX03541.1 - 0.43 10.8 0.0 0.43 10.8 0.0 2.5 3 0 0 3 3 3 0 Nuclear receptor repeat PRP1_N PF06424.12 EFX03542.1 - 4.9e-46 156.8 5.8 1.1e-45 155.6 5.8 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EFX03542.1 - 4.6e-29 98.6 62.0 1.3e-05 25.6 0.4 15.1 5 5 11 16 16 16 11 Tetratricopeptide repeat TPR_19 PF14559.6 EFX03542.1 - 1.5e-28 99.1 28.4 7.4e-08 32.8 0.2 10.5 5 3 5 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 EFX03542.1 - 6.3e-16 58.7 49.1 3.5e-06 27.5 2.7 8.8 6 1 1 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFX03542.1 - 9.7e-11 40.9 18.9 0.067 13.3 0.0 10.9 12 1 1 13 13 13 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFX03542.1 - 9.6e-10 38.2 7.3 3.9 8.1 0.0 10.0 10 2 1 11 11 9 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFX03542.1 - 2.5e-09 36.6 0.7 0.064 13.5 0.1 7.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFX03542.1 - 2.2e-05 24.1 8.6 1.3 8.8 0.0 6.3 5 1 1 6 6 6 2 TPR repeat ANAPC3 PF12895.7 EFX03542.1 - 0.0001 22.4 1.4 23 5.3 0.0 5.1 4 2 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EFX03542.1 - 0.00018 20.6 8.7 1.7 7.4 0.0 6.4 5 1 2 7 7 7 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 EFX03542.1 - 0.00091 18.5 40.0 0.14 11.3 0.6 7.2 3 2 3 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFX03542.1 - 0.007 16.1 0.9 3.5 7.6 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFX03542.1 - 0.027 14.6 27.2 0.12 12.6 1.8 6.9 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFX03542.1 - 0.1 12.7 1.9 9 6.6 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Suf PF05843.14 EFX03542.1 - 0.43 10.5 2.8 8 6.3 0.0 3.7 4 0 0 4 4 4 0 Suppressor of forked protein (Suf) Elongin_A PF06881.11 EFX03542.1 - 0.56 10.8 5.9 8.4 7.0 0.0 4.0 3 1 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A TPR_12 PF13424.6 EFX03542.1 - 0.8 10.0 19.1 16 5.9 0.1 7.4 7 1 1 8 8 8 0 Tetratricopeptide repeat stn_TNFRSF12A PF12191.8 EFX03543.1 - 0.044 14.0 0.1 0.11 12.8 0.1 1.7 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain PhoD PF09423.10 EFX03544.1 - 1.5e-45 155.7 0.6 4.1e-45 154.3 0.6 1.6 1 1 0 1 1 1 1 PhoD-like phosphatase Sortilin-Vps10 PF15902.5 EFX03545.1 - 5.1e-294 974.8 0.0 1.9e-153 511.4 0.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EFX03545.1 - 6.1e-90 300.1 16.7 1.9e-46 158.5 6.8 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EFX03545.1 - 4.9e-13 47.0 36.6 0.31 11.2 0.3 11.7 11 0 0 11 11 11 7 BNR/Asp-box repeat CHB_HEX_C PF03174.13 EFX03545.1 - 1.4e-06 28.2 0.8 0.17 11.9 0.1 6.0 6 0 0 6 6 6 1 Chitobiase/beta-hexosaminidase C-terminal domain PSII_BNR PF14870.6 EFX03545.1 - 6.9e-06 25.5 1.0 0.045 13.0 0.0 5.1 5 2 2 7 7 7 1 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.6 EFX03545.1 - 6e-05 22.5 2.5 9.1 5.5 0.0 5.7 4 3 2 6 6 6 2 BNR repeat-like domain BNR_6 PF15899.5 EFX03545.1 - 0.029 14.4 3.0 10 6.5 0.0 5.0 5 0 0 5 5 5 0 BNR-Asp box repeat Peptidase_C34 PF05413.11 EFX03545.1 - 0.73 10.1 2.1 18 5.6 0.4 2.7 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase preSET_CXC PF18264.1 EFX03545.1 - 0.77 10.3 9.0 2.4 8.7 1.6 2.7 2 0 0 2 2 2 0 CXC domain Mcp5_PH PF12814.7 EFX03546.1 - 2.7e-46 156.6 0.0 5.8e-46 155.6 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Fez1 PF06818.15 EFX03546.1 - 0.00015 22.3 19.3 0.00033 21.2 19.3 1.5 1 0 0 1 1 1 1 Fez1 DUF4338 PF14236.6 EFX03546.1 - 0.036 13.3 0.1 0.11 11.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4338) TPR_MLP1_2 PF07926.12 EFX03546.1 - 0.2 11.7 25.0 0.54 10.3 22.3 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 EFX03546.1 - 0.43 9.9 16.8 0.7 9.2 16.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EFX03546.1 - 0.48 9.3 18.0 0.77 8.6 18.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein KxDL PF10241.9 EFX03546.1 - 0.9 9.9 4.3 2.3 8.6 3.8 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein Exonuc_VII_L PF02601.15 EFX03546.1 - 2.1 7.8 9.8 3.6 7.1 9.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TACC_C PF05010.14 EFX03546.1 - 3 7.6 16.6 4.7 7.0 16.6 1.2 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Golgin_A5 PF09787.9 EFX03546.1 - 6 6.2 19.4 10 5.5 19.4 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 EFX03546.1 - 6.1 6.1 15.5 11 5.3 15.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EFX03546.1 - 8.8 6.4 23.4 1.5 8.9 9.6 2.4 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 EFX03546.1 - 9.8 6.2 7.8 2.1 8.4 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Methyltransf_23 PF13489.6 EFX03548.1 - 1.2e-08 34.9 0.0 2.4e-08 34.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03548.1 - 2e-06 28.4 0.0 4.5e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03548.1 - 2.9e-05 24.7 0.0 6e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03548.1 - 0.00066 20.3 0.0 0.0019 18.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03548.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain OCD_Mu_crystall PF02423.15 EFX03549.1 - 4.6e-07 29.1 0.0 0.0041 16.1 0.0 2.6 3 0 0 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EFX03549.1 - 0.0079 16.3 0.0 0.25 11.4 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NPR2 PF06218.11 EFX03550.1 - 8.6e-119 397.2 0.0 2.6e-118 395.6 0.0 1.6 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Serglycin PF04360.12 EFX03550.1 - 1.1 9.2 3.2 50 3.8 0.6 3.3 3 0 0 3 3 3 0 Serglycin SAM_KSR1 PF13543.6 EFX03551.1 - 0.026 14.6 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 Amidohydro_2 PF04909.14 EFX03552.1 - 1.7e-30 106.8 1.5 2.9e-30 106.1 1.5 1.4 1 1 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 EFX03552.1 - 0.094 12.1 0.0 0.24 10.7 0.0 1.7 2 0 0 2 2 2 0 TatD related DNase Sod_Fe_C PF02777.18 EFX03553.1 - 2.3e-16 59.8 0.0 3.3e-07 30.4 0.0 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFX03553.1 - 0.0023 18.4 0.0 0.0036 17.7 0.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Pkinase_C PF00433.24 EFX03554.1 - 0.047 14.4 0.1 0.2 12.4 0.1 2.1 2 0 0 2 2 2 0 Protein kinase C terminal domain TFB6 PF17110.5 EFX03555.1 - 3.5e-62 209.1 0.0 4.5e-62 208.8 0.0 1.1 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH SelB-wing_2 PF09106.11 EFX03555.1 - 0.03 14.5 0.1 0.056 13.6 0.1 1.4 1 0 0 1 1 1 0 Elongation factor SelB, winged helix SUR7 PF06687.12 EFX03556.1 - 3.7e-18 66.0 8.4 5.7e-18 65.3 8.4 1.3 1 0 0 1 1 1 1 SUR7/PalI family SDF PF00375.18 EFX03556.1 - 0.18 10.8 9.6 0.31 10.0 8.5 1.9 1 1 0 1 1 1 0 Sodium:dicarboxylate symporter family DUF2569 PF10754.9 EFX03556.1 - 0.25 11.8 3.3 0.26 11.7 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) AAA PF00004.29 EFX03558.1 - 1.4e-97 323.2 0.0 1.8e-47 161.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX03558.1 - 5.2e-24 83.8 7.0 1.2e-13 50.6 0.6 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EFX03558.1 - 2.8e-17 62.7 0.1 9.3e-17 61.0 0.1 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EFX03558.1 - 1.2e-13 51.1 0.0 1.3e-05 25.0 0.0 3.0 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFX03558.1 - 3.4e-13 50.1 0.0 2.9e-07 30.8 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFX03558.1 - 8.8e-13 49.0 0.0 0.00014 22.3 0.0 4.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EFX03558.1 - 5.5e-12 46.0 0.0 3.4e-05 24.0 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EFX03558.1 - 2.4e-11 43.8 0.4 5.7e-06 26.4 0.1 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFX03558.1 - 2.7e-09 37.4 0.4 0.024 14.9 0.1 4.2 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 EFX03558.1 - 5.9e-09 35.6 0.0 0.0015 17.8 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 EFX03558.1 - 1.1e-07 31.6 0.0 2.2e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 IstB_IS21 PF01695.17 EFX03558.1 - 2.8e-07 30.4 0.0 0.027 14.2 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EFX03558.1 - 4.5e-07 30.5 0.0 0.054 14.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EFX03558.1 - 4.7e-07 29.9 0.0 0.011 15.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EFX03558.1 - 1.2e-06 28.1 0.3 0.033 13.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EFX03558.1 - 1.8e-06 27.5 0.5 0.49 9.7 0.0 3.4 3 0 0 3 3 3 2 KaiC RNA_helicase PF00910.22 EFX03558.1 - 2.2e-06 28.0 0.0 0.034 14.5 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_7 PF12775.7 EFX03558.1 - 3.6e-06 26.6 0.0 0.052 13.1 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region DUF815 PF05673.13 EFX03558.1 - 7.5e-06 25.3 0.0 0.0069 15.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_25 PF13481.6 EFX03558.1 - 8.9e-06 25.4 4.9 0.74 9.4 0.1 4.9 3 2 2 5 5 5 1 AAA domain Vps4_C PF09336.10 EFX03558.1 - 2.3e-05 24.3 0.4 0.00014 21.8 0.1 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_28 PF13521.6 EFX03558.1 - 2.8e-05 24.4 0.0 0.31 11.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EFX03558.1 - 4e-05 23.4 0.0 0.37 10.5 0.0 3.2 2 2 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 EFX03558.1 - 4.6e-05 23.9 0.0 0.68 10.5 0.0 3.5 2 1 0 2 2 2 2 ABC transporter AAA_24 PF13479.6 EFX03558.1 - 5.8e-05 22.9 0.0 0.45 10.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 EFX03558.1 - 6.4e-05 22.2 0.0 0.097 11.7 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 PhoH PF02562.16 EFX03558.1 - 8.6e-05 22.1 0.2 0.45 9.9 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein TsaE PF02367.17 EFX03558.1 - 0.00022 21.2 0.0 0.69 9.9 0.0 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EFX03558.1 - 0.00031 20.8 0.0 0.067 13.2 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Bac_DnaA PF00308.18 EFX03558.1 - 0.00037 20.4 0.0 0.88 9.4 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein AAA_17 PF13207.6 EFX03558.1 - 0.00046 20.6 0.0 0.89 10.0 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_3 PF07726.11 EFX03558.1 - 0.00055 19.8 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EFX03558.1 - 0.00074 19.3 0.2 1.6 8.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 EFX03558.1 - 0.0015 18.4 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFX03558.1 - 0.0015 18.8 0.6 6.5 7.1 0.1 3.7 3 1 1 4 4 3 0 AAA domain DUF2075 PF09848.9 EFX03558.1 - 0.0023 17.3 0.0 0.93 8.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EFX03558.1 - 0.0027 17.7 0.1 1.3 8.9 0.0 2.9 3 0 0 3 3 3 1 NACHT domain Sigma54_activ_2 PF14532.6 EFX03558.1 - 0.0034 17.5 0.0 0.54 10.4 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 EFX03558.1 - 0.0059 16.6 0.0 10 5.9 0.0 3.4 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EFX03558.1 - 0.0073 16.1 0.0 0.65 9.7 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EFX03558.1 - 0.011 15.6 0.6 4.2 7.3 0.0 3.8 4 0 0 4 4 3 0 NTPase NB-ARC PF00931.22 EFX03558.1 - 0.013 14.7 0.0 1.5 7.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain IPT PF01745.16 EFX03558.1 - 0.023 14.1 0.0 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Zeta_toxin PF06414.12 EFX03558.1 - 0.033 13.5 0.5 13 5.0 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin KAP_NTPase PF07693.14 EFX03558.1 - 0.035 13.3 0.0 0.91 8.7 0.0 2.5 2 1 0 3 3 3 0 KAP family P-loop domain UFD1 PF03152.14 EFX03558.1 - 0.06 12.8 0.0 0.2 11.1 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 AAA_6 PF12774.7 EFX03558.1 - 0.087 11.8 0.1 9 5.1 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Cytidylate_kin2 PF13189.6 EFX03558.1 - 0.094 12.8 0.0 3.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase-like family CorA PF01544.18 EFX03559.1 - 4.8e-07 29.4 1.5 1.2e-06 28.1 1.5 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Asp PF00026.23 EFX03560.1 - 2.1e-66 224.5 6.9 2.7e-66 224.1 6.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX03560.1 - 7.3e-12 45.9 4.2 8.6e-08 32.6 0.0 3.0 3 1 1 4 4 4 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX03560.1 - 9.3e-05 23.0 4.1 0.17 12.6 0.1 3.1 2 1 0 2 2 2 2 Aspartyl protease Chitin_synth_1 PF01644.17 EFX03561.1 - 7.4e-68 227.6 0.0 1.1e-67 227.1 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EFX03561.1 - 1.8e-26 91.9 0.1 3.4e-26 91.0 0.1 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EFX03561.1 - 1.1e-24 86.9 0.0 2.1e-21 76.1 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EFX03561.1 - 2.3e-09 37.5 0.1 2.3e-09 37.5 0.1 2.3 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Asparaginase PF00710.20 EFX03562.1 - 3.2e-59 199.7 0.0 4.5e-59 199.2 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFX03562.1 - 1.2e-26 93.1 0.0 2.7e-26 92.0 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 EFX03562.1 - 7.9e-08 32.8 0.1 6.1e-07 29.9 0.1 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFX03562.1 - 2.4e-06 27.7 1.1 4e-05 23.9 0.2 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFX03562.1 - 1.1e-05 25.9 0.2 0.00018 22.0 0.0 2.6 1 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX03562.1 - 0.00063 20.0 1.4 0.0048 17.2 0.2 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX03562.1 - 0.0068 16.8 0.1 0.12 13.1 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ribosomal_L5e PF17144.4 EFX03563.1 - 8.1e-79 263.3 0.1 1.5e-78 262.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EFX03563.1 - 1.5e-33 115.6 11.7 1.5e-33 115.6 11.7 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DnaJ_C PF01556.18 EFX03564.1 - 1.5e-32 112.7 0.0 2.4e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFX03564.1 - 7.9e-25 86.8 1.4 1.2e-24 86.1 1.4 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFX03564.1 - 1.4e-08 34.9 20.5 1.4e-08 34.9 20.5 2.1 2 0 0 2 2 2 1 DnaJ central domain GLTP PF08718.11 EFX03565.1 - 2.5e-46 157.6 0.2 4.6e-46 156.8 0.1 1.5 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) Glyco_hydro_15 PF00723.21 EFX03566.1 - 1.1e-47 162.9 0.0 5.4e-43 147.4 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 OPT PF03169.15 EFX03567.1 - 3.5e-125 419.0 41.6 4e-125 418.8 41.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ATG7_N PF16420.5 EFX03568.1 - 1.5e-90 303.9 0.0 1.7e-55 188.8 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EFX03568.1 - 2.1e-45 155.0 0.0 3.3e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EFX03568.1 - 0.17 11.9 0.0 2.9 8.0 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFX03568.1 - 0.18 11.1 0.0 9.3 5.6 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TMEM154 PF15102.6 EFX03569.1 - 0.00085 19.2 0.2 0.0018 18.2 0.2 1.5 1 1 0 1 1 1 1 TMEM154 protein family BatD PF13584.6 EFX03569.1 - 0.01 14.7 0.5 0.013 14.3 0.5 1.1 1 0 0 1 1 1 0 Oxygen tolerance Glycophorin_A PF01102.18 EFX03569.1 - 0.011 15.9 0.3 0.021 15.0 0.3 1.5 1 0 0 1 1 1 0 Glycophorin A DUF4448 PF14610.6 EFX03569.1 - 0.017 14.9 0.0 0.017 14.9 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF4448) Adeno_E3_CR2 PF02439.15 EFX03569.1 - 0.047 13.5 0.7 0.088 12.6 0.7 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4381 PF14316.6 EFX03569.1 - 0.052 13.8 0.0 0.088 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF1970 PF09301.10 EFX03569.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1970) DUF2207 PF09972.9 EFX03569.1 - 0.16 10.7 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RIFIN PF02009.16 EFX03569.1 - 0.17 11.7 0.0 0.23 11.3 0.0 1.1 1 0 0 1 1 1 0 Rifin Stevor PF17410.2 EFX03569.1 - 0.23 11.0 0.0 0.31 10.6 0.0 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame MtrF PF09472.10 EFX03569.1 - 0.62 9.5 2.9 1.2 8.6 2.9 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) PTP_tm PF18861.1 EFX03569.1 - 1.6 8.7 4.5 2.7 7.9 4.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF202 PF02656.15 EFX03569.1 - 2.9 8.4 8.0 0.25 11.8 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) GT87 PF09594.10 EFX03569.1 - 3.2 7.4 7.7 0.063 13.0 1.1 1.5 2 0 0 2 2 2 0 Glycosyltransferase family 87 Ammonium_transp PF00909.21 EFX03569.1 - 8.3 5.0 13.6 12 4.4 13.6 1.1 1 0 0 1 1 1 0 Ammonium Transporter Family Glyco_hydro_43 PF04616.14 EFX03570.1 - 4.5e-34 118.1 3.6 5.8e-34 117.7 3.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 ThiF PF00899.21 EFX03571.1 - 1.4e-111 371.8 0.0 3.2e-74 249.4 0.0 2.3 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFX03571.1 - 5.6e-92 308.2 0.6 9.3e-92 307.5 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EFX03571.1 - 3.1e-30 104.7 0.2 1.1e-29 102.9 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin fold domain E1_FCCH PF16190.5 EFX03571.1 - 3.8e-30 103.9 0.0 9.2e-30 102.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EFX03571.1 - 9.4e-26 89.8 0.3 2.5e-25 88.4 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle NAD_binding_7 PF13241.6 EFX03571.1 - 0.095 13.2 0.0 1.3 9.5 0.0 2.9 3 0 0 3 3 3 0 Putative NAD(P)-binding Sugar_tr PF00083.24 EFX03572.1 - 6.5e-70 236.2 20.2 8.1e-70 235.9 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX03572.1 - 3.4e-26 92.0 24.8 4.2e-26 91.7 24.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EFX03572.1 - 2.8e-09 36.1 22.4 1.4e-05 23.9 5.9 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein TRI12 PF06609.13 EFX03572.1 - 3.1e-06 25.9 4.0 3.1e-06 25.9 4.0 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) UPF0182 PF03699.13 EFX03572.1 - 5.5 5.0 6.5 0.21 9.7 0.5 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) Proteasome PF00227.26 EFX03573.1 - 5.7e-49 166.2 0.0 7.3e-49 165.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFX03573.1 - 2.2e-11 43.2 0.2 4e-11 42.4 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature UPF0547 PF10571.9 EFX03574.1 - 0.016 15.3 0.2 0.046 13.8 0.2 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 p450 PF00067.22 EFX03575.1 - 3.9e-58 197.3 0.0 1.1e-57 195.9 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 EFX03576.1 - 5.9e-12 45.5 1.1 9.7e-12 44.8 1.1 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 EFX03576.1 - 9.4e-07 28.9 0.3 1.8e-06 28.0 0.3 1.5 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase PIG-H PF10181.9 EFX03577.1 - 7.4e-18 64.2 0.0 8.6e-17 60.8 0.0 2.4 2 1 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component VGCC_alpha2 PF08473.11 EFX03577.1 - 0.14 10.9 1.1 0.23 10.2 1.1 1.2 1 0 0 1 1 1 0 Neuronal voltage-dependent calcium channel alpha 2acd DUF4781 PF16013.5 EFX03577.1 - 6 5.6 9.8 0.16 10.8 2.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) TPR_1 PF00515.28 EFX03578.1 - 1.9e-37 125.6 23.7 6.5e-05 22.6 0.1 9.6 10 0 0 10 10 9 8 Tetratricopeptide repeat STI1 PF17830.1 EFX03578.1 - 2.8e-35 120.0 14.7 1.2e-19 69.9 3.7 3.0 3 0 0 3 3 3 2 STI1 domain TPR_2 PF07719.17 EFX03578.1 - 6.7e-29 97.6 33.8 6.8e-06 25.8 0.2 10.7 10 1 1 11 11 11 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFX03578.1 - 1.8e-22 78.7 8.3 7.9e-05 22.3 0.2 7.1 6 1 1 7 7 7 4 TPR repeat TPR_19 PF14559.6 EFX03578.1 - 2.1e-13 50.5 6.9 0.074 13.6 0.0 7.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFX03578.1 - 2.7e-13 49.0 24.2 0.00084 19.4 0.0 8.2 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFX03578.1 - 1.1e-10 41.1 3.5 2.3 8.8 0.0 7.9 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFX03578.1 - 2.2e-10 41.0 25.4 0.009 16.6 0.0 7.0 5 2 1 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 EFX03578.1 - 2.6e-10 39.6 2.4 0.029 14.4 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFX03578.1 - 4.4e-10 39.5 17.2 0.44 11.5 0.1 8.9 5 3 5 10 10 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFX03578.1 - 7.3e-10 39.0 12.5 1.7e-06 28.2 0.5 5.7 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFX03578.1 - 2e-08 34.2 7.7 0.00035 20.6 0.2 4.9 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX03578.1 - 0.31 11.0 0.0 0.31 11.0 0.0 6.8 7 1 1 8 8 8 0 Tetratricopeptide repeat DUF5486 PF17588.2 EFX03578.1 - 0.69 9.8 6.1 0.89 9.5 2.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5486) MIT PF04212.18 EFX03578.1 - 2.2 8.4 21.5 2.2 8.4 0.1 6.2 6 1 1 7 7 6 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EFX03578.1 - 2.4 8.3 5.3 28 4.9 0.0 4.0 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EFX03578.1 - 3.2 8.0 9.5 11 6.4 0.7 4.1 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 IU_nuc_hydro PF01156.19 EFX03579.1 - 2.1e-12 47.2 0.0 2.8e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase EF-hand_1 PF00036.32 EFX03580.1 - 6.3e-24 81.7 12.3 4.8e-08 32.0 0.2 4.7 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EFX03580.1 - 1.6e-23 82.9 8.7 4e-15 56.0 1.0 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFX03580.1 - 2.8e-23 79.8 5.0 1.7e-05 24.4 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EFX03580.1 - 5.2e-16 57.3 10.7 5.6e-05 22.5 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFX03580.1 - 3.2e-12 46.1 11.4 0.00027 20.7 0.9 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EFX03580.1 - 3.5e-07 30.1 7.8 0.0076 16.2 0.2 4.2 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFX03580.1 - 5e-05 23.5 0.5 0.0061 16.9 0.0 3.1 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EFX03580.1 - 0.0063 16.8 4.7 1.4 9.2 0.3 3.2 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Staphylokinase PF02821.16 EFX03580.1 - 0.023 15.1 0.1 4.1 7.8 0.0 2.6 1 1 1 2 2 2 0 Staphylokinase/Streptokinase family DUF1679 PF07914.11 EFX03580.1 - 0.069 12.0 0.5 2.6 6.8 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.6 EFX03580.1 - 0.1 12.4 1.9 1.9 8.4 0.1 3.3 4 0 0 4 4 4 0 EF hand EF-hand_14 PF17959.1 EFX03580.1 - 0.27 11.6 2.5 6.1 7.3 0.0 3.7 5 0 0 5 5 5 0 EF-hand domain RRM_1 PF00076.22 EFX03581.1 - 3.2e-84 276.7 3.1 7.7e-23 80.1 0.1 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EFX03581.1 - 1.3e-26 92.6 3.7 4.8e-26 90.7 0.9 3.2 4 0 0 4 4 4 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EFX03581.1 - 1.4e-10 40.8 0.0 0.28 10.8 0.0 5.3 2 1 3 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFX03581.1 - 1.2e-06 28.5 0.1 0.9 9.7 0.0 4.8 5 0 0 5 5 5 2 RNA recognition motif RRM_occluded PF16842.5 EFX03581.1 - 2.4e-06 27.3 0.0 0.0037 17.1 0.0 3.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFX03581.1 - 0.00015 21.7 1.0 17 5.5 0.1 4.7 4 1 0 4 4 4 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EFX03581.1 - 0.00044 20.2 11.8 1.4 9.0 0.2 5.1 5 1 0 5 5 5 2 RNA binding motif YflT PF11181.8 EFX03581.1 - 0.048 14.2 5.4 0.43 11.1 0.3 3.4 3 0 0 3 3 3 0 Heat induced stress protein YflT PhetRS_B1 PF18262.1 EFX03581.1 - 0.067 13.4 0.8 21 5.4 0.0 3.4 3 0 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain DUF4913 PF16259.5 EFX03581.1 - 0.18 11.9 0.0 3.4 7.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4913) OB_RNB PF08206.11 EFX03581.1 - 0.33 10.7 2.1 10 5.9 0.0 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain Glyco_hydro_76 PF03663.14 EFX03582.1 - 7.7e-141 469.9 9.1 9.1e-141 469.6 9.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFX03582.1 - 0.053 12.6 6.6 2.2 7.2 0.2 3.1 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 MAS20 PF02064.15 EFX03584.1 - 1e-40 138.8 0.2 1.2e-40 138.6 0.2 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor NCE101 PF11654.8 EFX03584.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Non-classical export protein 1 RRM_1 PF00076.22 EFX03585.1 - 1.1e-17 63.6 0.0 2.2e-09 37.0 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PBP1_TM PF14812.6 EFX03585.1 - 0.47 10.9 0.0 0.47 10.9 0.0 3.9 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spt20 PF12090.8 EFX03585.1 - 2.2 7.8 8.2 4.7 6.7 8.2 1.5 1 0 0 1 1 1 0 Spt20 family Surp PF01805.20 EFX03586.1 - 3.7e-07 30.0 0.0 7e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Surp module DUF2681 PF10883.8 EFX03587.1 - 0.0087 16.5 0.1 0.0087 16.5 0.1 3.1 4 0 0 4 4 4 1 Protein of unknown function (DUF2681) TMEM171 PF15471.6 EFX03587.1 - 1.4 7.8 5.3 3.1 6.7 5.3 1.5 1 0 0 1 1 1 0 Transmembrane protein family 171 UPF0160 PF03690.13 EFX03588.1 - 3.8e-123 411.2 0.0 4.4e-123 411.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ank_2 PF12796.7 EFX03589.1 - 5.7e-114 372.9 27.0 1.5e-13 51.1 0.2 13.0 1 1 14 16 16 16 16 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX03589.1 - 1.3e-76 252.0 12.9 7e-07 29.7 0.0 16.1 11 4 6 17 17 17 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX03589.1 - 2.2e-70 224.2 12.5 0.00092 19.5 0.0 22.1 23 0 0 23 23 23 16 Ankyrin repeat Ank_5 PF13857.6 EFX03589.1 - 5.1e-61 201.9 17.0 4e-06 27.0 0.0 16.9 9 4 9 18 18 18 15 Ankyrin repeats (many copies) Ank PF00023.30 EFX03589.1 - 9.7e-56 183.9 29.7 0.00036 20.9 0.0 20.7 20 1 0 20 20 20 14 Ankyrin repeat SPRY PF00622.28 EFX03589.1 - 4.9e-15 55.7 0.2 1.7e-14 54.0 0.0 2.0 2 0 0 2 2 2 1 SPRY domain NACHT PF05729.12 EFX03590.1 - 2.7e-16 59.9 0.0 1.7e-15 57.3 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EFX03590.1 - 1.5e-07 31.7 0.0 6.5e-07 29.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFX03590.1 - 1.1e-06 28.0 0.1 2.7e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFX03590.1 - 0.003 18.0 1.1 0.12 12.7 0.2 3.3 2 1 0 2 2 2 1 AAA ATPase domain DAP3 PF10236.9 EFX03590.1 - 0.009 15.2 0.1 0.29 10.3 0.0 2.5 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 NLRC4_HD2 PF17776.1 EFX03590.1 - 0.014 15.9 0.3 0.014 15.9 0.3 3.1 3 0 0 3 3 3 0 NLRC4 helical domain HD2 RNA_helicase PF00910.22 EFX03590.1 - 0.043 14.2 0.0 0.17 12.3 0.0 2.1 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EFX03590.1 - 0.043 13.7 0.1 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EFX03590.1 - 0.06 13.9 0.0 0.21 12.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFX03590.1 - 0.093 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase MeaB PF03308.16 EFX03590.1 - 0.12 11.3 0.0 0.29 10.1 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EFX03590.1 - 0.14 11.9 0.0 0.38 10.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFX03590.1 - 0.14 12.2 0.7 0.74 9.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain Arm PF00514.23 EFX03591.1 - 2.3e-73 240.2 30.4 8e-13 48.0 0.1 11.3 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFX03591.1 - 2e-16 60.1 11.6 0.0014 19.0 0.2 7.3 3 2 1 6 6 6 4 HEAT repeats HEAT_EZ PF13513.6 EFX03591.1 - 1.7e-15 57.1 16.2 0.0052 17.3 0.2 8.2 7 2 1 8 8 8 4 HEAT-like repeat HEAT PF02985.22 EFX03591.1 - 9.7e-14 50.3 16.8 0.16 12.3 0.1 9.2 10 0 0 10 10 8 4 HEAT repeat Adaptin_N PF01602.20 EFX03591.1 - 1.3e-13 50.3 9.6 5.9e-10 38.3 3.5 3.0 1 1 1 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.13 EFX03591.1 - 4.7e-13 49.2 3.9 3.5e-08 33.2 0.6 2.7 1 1 1 2 2 2 2 Armadillo-like KAP PF05804.12 EFX03591.1 - 5.9e-09 34.6 0.4 1.5e-08 33.4 0.2 1.8 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 EFX03591.1 - 3.6e-07 29.8 1.8 0.0059 15.9 0.4 3.5 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 EFX03591.1 - 1.7e-06 28.1 7.3 0.038 14.0 0.0 4.9 2 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 DUF5578 PF17741.1 EFX03591.1 - 0.00027 20.5 7.1 0.22 10.9 0.0 5.0 2 2 5 7 7 7 3 Family of unknown function (DUF5578) DUF3361 PF11841.8 EFX03591.1 - 0.00036 20.5 5.5 1.8 8.5 0.0 4.3 2 1 3 5 5 5 2 Domain of unknown function (DUF3361) IFRD PF05004.13 EFX03591.1 - 0.016 14.3 6.2 0.97 8.5 0.1 3.9 3 2 1 4 4 4 0 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.16 EFX03591.1 - 0.026 15.2 8.5 6.4 7.8 0.3 6.4 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Sdh5 PF03937.16 EFX03591.1 - 0.071 13.1 0.0 2.1 8.4 0.0 2.6 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase RTP1_C1 PF10363.9 EFX03591.1 - 0.094 12.9 1.6 55 4.0 0.0 4.4 3 1 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Atx10homo_assoc PF09759.9 EFX03591.1 - 0.27 11.3 4.8 3.4 7.7 0.4 4.1 3 1 2 5 5 5 0 Spinocerebellar ataxia type 10 protein domain RPN7 PF10602.9 EFX03593.1 - 1e-46 158.8 0.0 1.7e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFX03593.1 - 8.2e-16 58.4 0.1 3.1e-15 56.6 0.0 2.0 2 0 0 2 2 2 1 PCI domain BLYB PF05289.11 EFX03593.1 - 0.00075 19.7 0.1 0.0018 18.5 0.1 1.6 1 0 0 1 1 1 1 Borrelia hemolysin accessory protein TPR_2 PF07719.17 EFX03593.1 - 0.27 11.4 2.8 28 5.2 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SWIRM PF04433.17 EFX03594.1 - 2.9e-32 110.8 0.3 6.4e-32 109.8 0.3 1.6 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EFX03594.1 - 6.1e-32 109.4 4.5 1.3e-31 108.4 4.5 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EFX03594.1 - 2.3e-08 34.1 0.0 5.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX03594.1 - 9.8e-05 22.5 0.1 0.0002 21.5 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EFX03594.1 - 0.00025 20.8 2.3 0.00045 20.0 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SANT_DAMP1_like PF16282.5 EFX03594.1 - 0.014 15.6 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 ERO1 PF04137.15 EFX03595.1 - 2e-136 454.8 0.0 2.5e-136 454.5 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) CKS PF01111.19 EFX03595.1 - 3.6e-31 107.2 4.0 6.3e-31 106.5 2.5 2.1 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit RPA_interact_N PF14766.6 EFX03595.1 - 0.027 14.1 0.0 1.2 8.8 0.0 2.6 2 0 0 2 2 2 0 Replication protein A interacting N-terminal Deltameth_res PF16020.5 EFX03596.1 - 0.01 15.7 0.7 0.08 12.8 0.1 2.5 2 0 0 2 2 2 0 Deltamethrin resistance DUF423 PF04241.15 EFX03596.1 - 0.083 13.1 2.6 5.4 7.3 0.1 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF423) DUF5134 PF17197.4 EFX03596.1 - 8.4 6.3 7.4 4.5 7.2 0.7 2.8 2 2 1 3 3 3 0 Domain of unknown function (DUF5134) DUF3684 PF12449.8 EFX03597.1 - 0 1426.8 0.0 0 1426.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EFX03597.1 - 0.00074 19.4 0.0 0.006 16.4 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_carr PF00153.27 EFX03598.1 - 8.4e-16 57.7 5.9 1e-07 31.8 0.1 3.8 3 2 1 4 4 4 3 Mitochondrial carrier protein ThrE PF06738.12 EFX03598.1 - 0.29 10.5 2.8 9.3 5.5 0.1 2.9 3 0 0 3 3 3 0 Putative threonine/serine exporter RskA PF10099.9 EFX03598.1 - 0.87 9.9 8.0 3.1 8.1 4.9 2.3 2 1 0 2 2 2 0 Anti-sigma-K factor rskA QCR10 PF09796.9 EFX03598.1 - 6.2 7.0 7.9 3 8.0 1.5 3.0 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) VIT1 PF01988.19 EFX03598.1 - 7.4 6.4 9.5 18 5.1 2.8 2.7 3 0 0 3 3 3 0 VIT family HNH_2 PF13391.6 EFX03599.1 - 2.9e-07 30.5 0.5 1.3e-06 28.4 0.3 2.2 2 1 0 2 2 2 1 HNH endonuclease LNS2 PF08235.13 EFX03600.1 - 7.2e-93 310.2 0.0 9.9e-93 309.8 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EFX03600.1 - 6.4e-43 144.9 0.0 1.8e-42 143.4 0.0 1.8 2 0 0 2 2 2 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EFX03600.1 - 0.0034 17.0 0.0 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) WRNPLPNID PF15017.6 EFX03600.1 - 0.64 10.9 7.7 2.1 9.3 7.7 2.0 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Fe_hyd_lg_C PF02906.14 EFX03601.1 - 7.3e-49 166.6 0.0 4.2e-48 164.2 0.0 2.0 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain HMG-CoA_red PF00368.18 EFX03602.1 - 9.4e-141 469.1 5.1 1.3e-140 468.7 5.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EFX03602.1 - 1.3e-47 161.5 0.2 2.4e-47 160.7 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EFX03602.1 - 2.2e-12 47.1 6.1 1.3e-08 34.8 6.1 2.6 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EFX03602.1 - 2.9e-06 25.7 2.2 2.9e-06 25.7 2.2 1.5 2 0 0 2 2 2 1 Patched family Ank_2 PF12796.7 EFX03603.1 - 8.9e-24 83.9 0.1 1e-09 38.8 0.0 4.7 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFX03603.1 - 2e-18 65.9 3.6 0.00031 21.0 0.0 7.0 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EFX03603.1 - 8.7e-15 54.6 3.0 8e-07 29.2 0.1 5.7 5 2 1 6 6 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFX03603.1 - 2.5e-12 47.1 0.5 0.0095 16.5 0.0 5.9 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX03603.1 - 3.3e-12 45.4 0.2 0.5 11.1 0.0 7.4 7 0 0 7 7 6 2 Ankyrin repeat AAA_16 PF13191.6 EFX03603.1 - 0.0018 18.6 0.0 0.0073 16.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFX03603.1 - 0.0025 18.1 0.0 0.0092 16.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFX03603.1 - 0.024 15.1 0.0 0.14 12.6 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EFX03603.1 - 0.094 12.3 0.0 0.33 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFX03603.1 - 0.13 12.4 0.0 0.45 10.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain NodZ PF05830.11 EFX03603.1 - 0.17 10.7 0.4 2.7 6.7 0.0 2.5 3 0 0 3 3 3 0 Nodulation protein Z (NodZ) Ribosomal_L11 PF00298.19 EFX03604.1 - 3.2e-26 91.6 0.2 7.2e-26 90.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EFX03604.1 - 7.3e-26 89.8 0.1 1e-25 89.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_S5 PF00333.20 EFX03605.1 - 1.6e-20 72.8 0.8 3.4e-20 71.8 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFX03605.1 - 1.8e-20 72.1 0.0 3.8e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain ZZ PF00569.17 EFX03606.1 - 7.6e-10 38.5 6.9 1.3e-09 37.8 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 EFX03606.1 - 0.013 15.8 5.9 0.023 15.0 5.9 1.4 1 0 0 1 1 1 0 C1 domain EF-hand_1 PF00036.32 EFX03606.1 - 0.42 10.3 1.8 3 7.6 1.2 2.5 2 0 0 2 2 2 0 EF hand DNA_pol_phi PF04931.13 EFX03606.1 - 4.2 5.3 13.9 8.2 4.4 13.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi Vfa1 PF08432.10 EFX03606.1 - 7.5 6.8 12.7 2.3 8.5 6.3 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PALP PF00291.25 EFX03607.1 - 2.1e-52 178.4 7.6 2e-50 171.9 7.6 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thioredoxin PF00085.20 EFX03608.1 - 1.3e-33 115.1 0.0 4.5e-25 87.6 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EFX03608.1 - 5.2e-07 30.1 0.2 0.03 14.8 0.0 2.9 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_6 PF13848.6 EFX03608.1 - 2.3e-06 27.7 0.0 0.019 14.9 0.0 2.7 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFX03608.1 - 2.7e-06 26.9 0.0 0.00019 20.9 0.0 2.3 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family TraF PF13728.6 EFX03608.1 - 0.00044 20.1 6.4 0.089 12.6 0.0 3.4 3 0 0 3 3 3 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 EFX03608.1 - 0.0013 19.0 0.0 1.9 8.8 0.0 3.7 3 1 1 4 4 4 1 Thioredoxin-like Calsequestrin PF01216.17 EFX03608.1 - 0.045 12.8 0.1 0.19 10.8 0.0 1.9 2 0 0 2 2 2 0 Calsequestrin ERp29_N PF07912.13 EFX03608.1 - 0.077 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 ERp29, N-terminal domain DUF4551 PF15087.6 EFX03608.1 - 0.12 11.2 1.2 0.16 10.7 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CPSF100_C PF13299.6 EFX03608.1 - 0.15 12.2 2.5 0.27 11.4 2.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Thioredoxin_7 PF13899.6 EFX03608.1 - 0.15 12.2 0.0 0.47 10.7 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like DUF3403 PF11883.8 EFX03609.1 - 0.015 15.4 2.6 4.1 7.6 0.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF3403) Metallophos PF00149.28 EFX03610.1 - 1.5e-37 130.1 0.1 1.1e-36 127.2 0.1 2.5 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase TauD PF02668.16 EFX03610.1 - 3.4e-36 125.4 0.3 5.8e-36 124.7 0.3 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EFX03610.1 - 0.0089 16.6 0.0 0.02 15.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) DUF349 PF03993.12 EFX03611.1 - 0.19 12.0 1.2 0.19 12.0 0.1 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) AA_permease PF00324.21 EFX03612.1 - 1.5e-140 469.0 35.0 1.9e-140 468.7 35.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX03612.1 - 9.2e-44 149.9 37.8 1.2e-43 149.5 37.8 1.0 1 0 0 1 1 1 1 Amino acid permease CRAL_TRIO PF00650.20 EFX03614.1 - 2.1e-45 154.3 0.9 2.7e-45 153.9 0.1 1.5 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFX03614.1 - 8.5e-13 48.3 0.2 8.5e-13 48.3 0.2 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFX03614.1 - 7.9e-08 32.6 0.0 1.4e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain AP3D1 PF06375.11 EFX03614.1 - 0.034 14.4 3.2 0.063 13.5 3.2 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DNA_pol_A_exoN PF18305.1 EFX03614.1 - 0.095 13.0 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 3' to 5' exonuclease C-terminal domain DUF5427 PF10310.9 EFX03617.1 - 2.8e-167 557.4 0.0 3.4e-167 557.1 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Telomere_reg-2 PF10193.9 EFX03618.1 - 2.9e-36 124.2 0.0 8.1e-36 122.8 0.0 1.9 1 0 0 1 1 1 1 Telomere length regulation protein Zn_clus PF00172.18 EFX03619.1 - 2.6e-06 27.5 8.8 5.1e-06 26.5 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aa_trans PF01490.18 EFX03620.1 - 5.9e-84 282.1 28.6 7.9e-84 281.7 28.6 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EnY2 PF10163.9 EFX03621.1 - 0.0098 16.2 0.0 0.019 15.3 0.0 1.5 2 0 0 2 2 2 1 Transcription factor e(y)2 M-factor PF03855.13 EFX03621.1 - 4.4 7.5 7.2 8.5 6.6 7.2 1.5 1 0 0 1 1 1 0 M-factor COG5 PF10392.9 EFX03622.1 - 1.3e-40 138.6 1.2 8.7e-40 136.0 0.1 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 DUF2046 PF09755.9 EFX03622.1 - 0.042 13.1 0.4 0.067 12.4 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) GrpE PF01025.19 EFX03622.1 - 0.1 12.3 0.4 0.19 11.4 0.4 1.3 1 0 0 1 1 1 0 GrpE Acetyltransf_18 PF18014.1 EFX03622.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SRX PF09201.10 EFX03622.1 - 0.19 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit HrpB7 PF09486.10 EFX03622.1 - 4.6 7.6 8.8 0.71 10.2 0.4 2.7 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF1279 PF06916.13 EFX03623.1 - 3.8e-26 91.5 0.3 6.1e-26 90.8 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Tubulin PF00091.25 EFX03624.1 - 1.7e-47 162.2 0.3 2.1e-43 148.9 0.1 2.2 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFX03624.1 - 9.1e-44 148.7 0.2 3e-43 147.0 0.1 1.8 2 0 0 2 2 2 1 Tubulin C-terminal domain Hrs_helical PF12210.8 EFX03624.1 - 0.11 13.1 0.3 0.56 10.8 0.0 2.3 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Chorismate_bind PF00425.18 EFX03625.1 - 1.9e-65 221.0 0.0 2.7e-65 220.5 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EFX03625.1 - 7.7e-25 87.8 0.0 2.2e-24 86.3 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EFX03625.1 - 1.3e-11 44.9 0.0 4e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EFX03625.1 - 2e-05 24.5 0.1 0.0022 17.8 0.1 2.2 2 0 0 2 2 2 2 Peptidase C26 dCMP_cyt_deam_1 PF00383.23 EFX03626.1 - 3e-27 94.5 0.5 4.4e-27 93.9 0.5 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFX03626.1 - 5.3e-11 42.4 0.0 8.2e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 EFX03626.1 - 0.0016 19.0 0.3 0.02 15.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 EFX03626.1 - 0.0091 15.7 0.1 0.015 14.9 0.1 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase SNAD4 PF18750.1 EFX03626.1 - 0.059 13.5 0.2 0.1 12.7 0.2 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 AAA_33 PF13671.6 EFX03626.1 - 0.061 13.5 0.1 0.37 10.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EFX03626.1 - 0.2 11.4 0.1 0.68 9.6 0.1 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family HA2 PF04408.23 EFX03627.1 - 1.5e-20 73.5 0.0 1.5e-20 73.5 0.0 3.2 3 1 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFX03627.1 - 5.5e-11 42.8 0.0 3.3e-10 40.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EFX03627.1 - 5.7e-10 39.4 0.1 3.1e-09 37.1 0.0 2.3 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EFX03627.1 - 4e-07 30.0 0.0 1.2e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EFX03627.1 - 4.4e-05 23.9 0.0 0.0001 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX03627.1 - 0.00012 21.9 0.1 0.00061 19.6 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX03627.1 - 0.00083 19.6 0.0 0.0026 18.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFX03627.1 - 0.00091 18.4 0.0 0.002 17.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein ATPase PF06745.13 EFX03627.1 - 0.038 13.3 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.6 EFX03627.1 - 0.041 14.4 0.0 0.041 14.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 EFX03627.1 - 0.12 12.3 0.0 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SPATA3 PF15662.5 EFX03627.1 - 4.7 7.8 11.9 0.21 12.2 4.6 2.3 2 0 0 2 2 2 0 Spermatogenesis-associated protein 3 family G_glu_transpept PF01019.21 EFX03628.1 - 3.2e-118 395.7 0.1 4.2e-118 395.3 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF3246 PF11596.8 EFX03628.1 - 5.3 6.4 6.4 0.91 8.9 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) PfkB PF00294.24 EFX03630.1 - 1.6e-47 162.3 1.2 7.2e-47 160.1 1.2 1.8 1 1 0 1 1 1 1 pfkB family carbohydrate kinase DNAPolymera_Pol PF11590.8 EFX03630.1 - 0.073 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase catalytic subunit Pol Peptidase_S28 PF05577.12 EFX03631.1 - 9.2e-45 153.2 0.0 4e-38 131.3 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Ank_4 PF13637.6 EFX03632.1 - 2.3e-14 53.5 0.1 4.1e-09 36.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX03632.1 - 1.4e-13 51.2 0.1 1.8e-13 50.9 0.1 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFX03632.1 - 8.5e-11 41.8 0.9 7.7e-05 23.0 0.0 2.9 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFX03632.1 - 9.8e-11 40.9 0.1 0.00065 20.0 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFX03632.1 - 6.2e-07 29.6 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) VWA_3_C PF18571.1 EFX03632.1 - 0.88 9.5 4.5 22 5.0 0.3 3.1 3 0 0 3 3 3 0 von Willebrand factor type A C-terminal domain Ponericin PF07442.11 EFX03634.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Ponericin Peptidase_S8 PF00082.22 EFX03635.1 - 3.2e-25 89.0 6.6 6.2e-25 88.1 6.6 1.4 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EFX03635.1 - 1.5e-08 35.3 0.1 7.4e-08 33.1 0.0 2.2 3 0 0 3 3 3 1 Fn3-like domain FlgD_ig PF13860.6 EFX03635.1 - 0.00071 19.4 0.1 0.0029 17.4 0.0 2.1 2 0 0 2 2 2 1 FlgD Ig-like domain FAD_binding_4 PF01565.23 EFX03636.1 - 1.9e-26 92.5 3.4 3.4e-26 91.6 3.4 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX03636.1 - 1.4e-10 41.1 0.0 2.7e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Septin PF00735.18 EFX03637.1 - 1.8e-114 381.8 0.2 2.6e-114 381.3 0.2 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EFX03637.1 - 2.1e-07 31.0 0.0 4.2e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX03637.1 - 8.7e-07 28.7 2.1 7.7e-05 22.3 0.1 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFX03637.1 - 2.4e-06 27.5 1.0 3.1e-05 23.9 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 EFX03637.1 - 0.0018 18.5 0.9 0.005 17.1 0.1 2.2 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 EFX03637.1 - 0.0025 17.3 0.1 0.0052 16.3 0.1 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 EFX03637.1 - 0.0035 17.5 0.1 0.0078 16.4 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFX03637.1 - 0.0076 15.6 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Casc1_N PF15927.5 EFX03637.1 - 0.0082 15.9 8.7 0.022 14.4 8.7 1.6 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus IIGP PF05049.13 EFX03637.1 - 0.0093 15.1 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.6 EFX03637.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX03637.1 - 0.014 15.8 1.3 0.063 13.7 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 EFX03637.1 - 0.019 14.5 0.5 0.062 12.9 0.5 1.9 2 1 0 2 2 1 0 Ras family KAP_NTPase PF07693.14 EFX03637.1 - 0.028 13.7 0.0 0.042 13.1 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain FOXP-CC PF16159.5 EFX03637.1 - 0.047 14.3 0.8 0.047 14.3 0.8 2.3 2 1 0 2 2 1 0 FOXP coiled-coil domain T2SSE PF00437.20 EFX03637.1 - 0.051 12.6 0.4 0.18 10.9 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 EFX03637.1 - 0.053 13.4 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EFX03637.1 - 0.054 14.0 0.2 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EFX03637.1 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 EFX03637.1 - 0.099 12.2 0.2 0.38 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EFX03637.1 - 0.14 11.9 0.4 8.3 6.2 0.1 2.6 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EFX03637.1 - 0.15 12.5 0.0 0.43 11.0 0.0 1.8 2 0 0 2 2 1 0 RNA helicase Dynamin_N PF00350.23 EFX03637.1 - 0.45 10.6 6.9 4.2 7.4 0.1 3.1 2 1 1 3 3 3 0 Dynamin family Ribosomal_L6e PF01159.19 EFX03637.1 - 0.49 10.9 5.4 7.6 7.1 0.2 3.3 3 0 0 3 3 3 0 Ribosomal protein L6e DivIC PF04977.15 EFX03637.1 - 0.55 10.0 7.0 0.16 11.8 2.3 2.4 2 0 0 2 2 2 0 Septum formation initiator Lge1 PF11488.8 EFX03637.1 - 0.73 10.1 9.6 4.8 7.4 3.7 3.2 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 Atg14 PF10186.9 EFX03637.1 - 0.81 8.7 4.5 1.6 7.7 4.5 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_11 PF13086.6 EFX03637.1 - 3.8 7.2 7.0 23 4.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain Seryl_tRNA_N PF02403.22 EFX03637.1 - 4.2 7.6 8.9 3.8 7.8 4.6 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain eIF-3_zeta PF05091.12 EFX03638.1 - 3.7e-204 679.5 0.0 6.1e-204 678.8 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_1 PF00170.21 EFX03638.1 - 0.00016 21.7 11.0 0.00026 21.0 11.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor DUF569 PF04601.13 EFX03638.1 - 0.058 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF569) bZIP_2 PF07716.15 EFX03638.1 - 0.068 13.3 10.2 0.15 12.2 3.4 2.3 2 0 0 2 2 2 0 Basic region leucine zipper DUF5082 PF16888.5 EFX03638.1 - 0.19 12.0 2.1 0.34 11.2 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) YabA PF06156.13 EFX03638.1 - 0.24 12.1 0.4 0.45 11.2 0.4 1.4 1 0 0 1 1 1 0 Initiation control protein YabA Nup_retrotrp_bd PF10599.9 EFX03638.1 - 0.8 10.4 6.0 2.4 8.9 6.0 1.8 1 0 0 1 1 1 0 Retro-transposon transporting motif Dynactin PF12455.8 EFX03639.1 - 5.8e-108 360.5 2.1 5.8e-108 360.5 2.1 4.2 4 1 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.25 EFX03639.1 - 5.1e-22 77.7 0.3 9.4e-22 76.8 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain SSTK-IP PF15836.5 EFX03640.1 - 0.0056 16.8 0.4 0.0056 16.8 0.4 3.3 3 0 0 3 3 3 2 SSTK-interacting protein, TSSK6-activating co-chaperone protein NACHT_N PF17100.5 EFX03641.1 - 3e-71 239.8 2.7 7.9e-71 238.4 1.1 2.4 3 0 0 3 3 3 1 N-terminal domain of NWD NACHT-NTPase NACHT PF05729.12 EFX03641.1 - 6.4e-11 42.4 0.0 1.7e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.7 EFX03641.1 - 7.3e-11 42.5 0.1 3.4e-10 40.4 0.0 2.3 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFX03641.1 - 1.7e-08 34.6 0.0 4.8e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX03641.1 - 6.1e-08 32.3 0.0 3.8e-05 23.8 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EFX03641.1 - 7.2e-07 29.6 0.0 1.9e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFX03641.1 - 7.2e-06 26.2 0.0 5.6e-05 23.4 0.0 2.6 3 0 0 3 3 2 1 Ankyrin repeat AAA_16 PF13191.6 EFX03641.1 - 0.00012 22.5 0.0 0.00057 20.3 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFX03641.1 - 0.0069 16.7 0.2 0.044 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFX03641.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AHSP PF09236.10 EFX03641.1 - 0.93 10.0 6.4 1.2 9.6 0.2 3.7 3 1 1 4 4 4 0 Alpha-haemoglobin stabilising protein IBN_N PF03810.19 EFX03642.1 - 1.9e-14 53.4 0.1 6.4e-13 48.4 0.0 3.3 3 1 1 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFX03642.1 - 1.9e-05 24.7 1.9 0.00039 20.5 0.2 3.3 3 0 0 3 3 3 1 Exportin 1-like protein DUF3385 PF11865.8 EFX03642.1 - 0.00022 21.2 0.5 0.19 11.6 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF3385) LIM PF00412.22 EFX03643.1 - 2.2e-24 85.4 11.5 2.9e-12 46.6 4.6 2.3 2 0 0 2 2 2 2 LIM domain WRC PF08879.10 EFX03643.1 - 0.13 11.9 0.8 0.36 10.6 0.5 1.9 2 0 0 2 2 2 0 WRC Plasmodium_Vir PF05795.11 EFX03644.1 - 1.9 7.8 12.8 2.4 7.5 12.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CCDC84 PF14968.6 EFX03644.1 - 2 7.9 8.8 2.9 7.4 8.8 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 Utp14 PF04615.13 EFX03644.1 - 4.1 5.8 20.0 5.1 5.6 20.0 1.0 1 0 0 1 1 1 0 Utp14 protein Hid1 PF12722.7 EFX03644.1 - 8.9 4.3 18.4 10 4.1 18.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Chromo PF00385.24 EFX03645.1 - 7.6e-15 54.6 0.2 1.1e-14 54.0 0.2 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Herpes_UL3 PF03369.13 EFX03645.1 - 0.31 11.6 1.5 0.65 10.5 1.5 1.6 1 0 0 1 1 1 0 Herpesvirus UL3 protein Avl9 PF09794.9 EFX03647.1 - 6.1e-141 469.5 0.0 7.8e-141 469.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 EFX03647.1 - 0.004 16.8 0.1 0.12 12.0 0.0 3.0 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) RXT2_N PF08595.11 EFX03647.1 - 4.2 7.4 5.8 8.9 6.3 5.8 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.12 EFX03647.1 - 4.7 5.3 10.5 7.3 4.7 10.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 EFX03647.1 - 6 5.9 14.7 10 5.1 14.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cupin_8 PF13621.6 EFX03648.1 - 2.8e-11 43.6 1.3 2.2e-09 37.4 0.5 3.0 2 1 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 EFX03648.1 - 2.8e-08 33.6 0.0 4.5e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EFX03648.1 - 0.0057 17.1 0.0 0.0094 16.4 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 EFX03648.1 - 0.0091 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Pribosyltran_N PF13793.6 EFX03649.1 - 3.1e-42 143.2 0.0 2.8e-41 140.1 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFX03649.1 - 2.9e-33 115.5 0.0 1.5e-28 100.1 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFX03649.1 - 2.8e-09 36.7 0.0 1e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 Phosphoribosyl transferase domain TFIID-31kDa PF02291.15 EFX03650.1 - 8.5e-40 135.6 0.0 1.8e-39 134.6 0.0 1.5 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit FAM150 PF15129.6 EFX03650.1 - 0.13 12.4 1.1 0.21 11.7 1.1 1.2 1 0 0 1 1 1 0 FAM150 family PepSY_TM PF03929.16 EFX03650.1 - 0.18 11.5 5.3 6.7 6.3 4.2 2.2 2 0 0 2 2 2 0 PepSY-associated TM region Corona_nucleoca PF00937.18 EFX03650.1 - 0.7 8.9 9.7 1 8.3 9.7 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein PAT1 PF09770.9 EFX03650.1 - 0.8 7.9 10.3 0.97 7.6 10.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.14 EFX03650.1 - 1.2 9.0 11.6 1.6 8.6 11.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pex14_N PF04695.13 EFX03650.1 - 1.5 9.4 19.8 3 8.5 19.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 EFX03650.1 - 2.3 7.8 16.9 3.9 7.0 16.9 1.4 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 EFX03650.1 - 2.9 6.4 8.9 3.4 6.2 8.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFX03650.1 - 4.6 5.9 6.5 6.7 5.4 6.5 1.2 1 0 0 1 1 1 0 Presenilin eIF2A PF08662.11 EFX03651.1 - 3.1e-78 262.1 0.0 1.1e-77 260.3 0.0 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EFX03651.1 - 0.00016 22.4 1.2 4.4 8.4 0.0 4.8 3 2 1 4 4 4 2 WD domain, G-beta repeat FH2 PF02181.23 EFX03652.1 - 6.1e-80 269.1 0.6 6.1e-80 269.1 0.6 1.7 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFX03652.1 - 5.7e-65 218.4 0.0 5.7e-65 218.4 0.0 2.3 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFX03652.1 - 2e-54 184.2 2.7 2.3e-53 180.7 1.1 2.6 1 1 1 2 2 2 1 Diaphanous FH3 Domain DUF1989 PF09347.10 EFX03653.1 - 3.2e-50 170.0 0.1 6e-28 97.6 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF1989) AA_permease_2 PF13520.6 EFX03654.1 - 2.7e-42 145.1 47.2 1.9e-40 139.0 47.2 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX03654.1 - 3.8e-16 58.8 38.3 5.8e-09 35.1 9.4 2.1 2 0 0 2 2 2 2 Amino acid permease Myotub-related PF06602.14 EFX03655.1 - 7.9e-149 495.4 0.0 9.8e-149 495.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DUF2939 PF11159.8 EFX03657.1 - 0.05 14.0 0.3 0.05 14.0 0.3 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2939) SelP_N PF04592.14 EFX03657.1 - 0.46 9.9 20.5 0.67 9.3 20.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region EPL1 PF10513.9 EFX03657.1 - 0.68 10.3 9.5 1.1 9.7 9.5 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like TFIIA PF03153.13 EFX03657.1 - 1.3 8.9 15.3 1.8 8.5 15.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 EFX03657.1 - 2.1 6.3 26.1 2.8 5.9 26.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM76 PF16046.5 EFX03657.1 - 2.7 7.3 12.0 3.7 6.8 12.0 1.1 1 0 0 1 1 1 0 FAM76 protein Macoilin PF09726.9 EFX03657.1 - 4.3 5.8 16.0 5.8 5.3 16.0 1.1 1 0 0 1 1 1 0 Macoilin family PAP1 PF08601.10 EFX03657.1 - 4.5 6.9 23.1 7.2 6.2 23.1 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 SOG2 PF10428.9 EFX03657.1 - 4.8 6.3 21.6 6.7 5.8 21.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein PAT1 PF09770.9 EFX03657.1 - 5 5.3 11.7 6.4 4.9 11.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 EFX03657.1 - 5.2 4.1 15.0 6.2 3.8 15.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 EFX03657.1 - 6.5 6.3 14.7 9.6 5.7 14.7 1.2 1 0 0 1 1 1 0 Spt20 family UQ_con PF00179.26 EFX03658.1 - 6.1e-48 162.0 0.0 6.8e-48 161.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX03658.1 - 7e-05 22.5 0.0 8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFX03658.1 - 0.068 13.5 0.8 0.11 12.8 0.8 1.5 1 1 0 1 1 1 0 RWD domain Glyco_hydro_18 PF00704.28 EFX03660.1 - 3.2e-19 69.8 1.5 8.4e-19 68.4 0.3 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 BRO1 PF03097.18 EFX03661.1 - 1.2e-130 435.9 0.1 1.2e-130 435.9 0.1 2.3 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EFX03661.1 - 1.5e-78 264.1 20.6 2.3e-78 263.5 20.6 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Clat_adaptor_s PF01217.20 EFX03661.1 - 1.1e-54 184.2 3.1 1.4e-54 183.9 1.7 1.9 2 0 0 2 2 2 1 Clathrin adaptor complex small chain DUF1539 PF07560.11 EFX03661.1 - 0.1 12.7 5.0 1.7 8.7 0.0 3.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1539) FlaC_arch PF05377.11 EFX03661.1 - 0.13 12.6 0.5 1.8 9.0 0.0 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Phage_tail_APC PF16778.5 EFX03661.1 - 0.14 12.0 0.1 0.55 10.1 0.1 2.0 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Gp58 PF07902.11 EFX03661.1 - 0.24 9.7 8.4 0.44 8.8 8.4 1.4 1 0 0 1 1 1 0 gp58-like protein COG2 PF06148.11 EFX03661.1 - 5.5 7.1 9.0 0.35 10.9 1.7 2.9 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Epimerase PF01370.21 EFX03662.1 - 7.3e-06 25.6 0.0 3.4e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFX03662.1 - 0.00033 20.3 0.0 0.00065 19.3 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 EFX03662.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein Sacchrp_dh_NADP PF03435.18 EFX03662.1 - 0.1 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain CAT_RBD PF03123.15 EFX03662.1 - 0.19 11.7 0.4 0.5 10.4 0.4 1.6 1 0 0 1 1 1 0 CAT RNA binding domain MFS_1 PF07690.16 EFX03664.1 - 8.2e-33 113.8 31.3 1.5e-32 112.9 26.1 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Methyltransf_23 PF13489.6 EFX03665.1 - 9.5e-15 54.8 0.0 1.3e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03665.1 - 5e-08 33.5 0.0 2.3e-07 31.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03665.1 - 5.4e-07 30.2 0.0 1.9e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03665.1 - 5.9e-06 26.2 0.0 0.11 12.3 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03665.1 - 0.00015 22.5 0.0 0.0031 18.2 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EFX03665.1 - 0.0014 18.7 0.0 0.0031 17.6 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EFX03665.1 - 0.002 17.6 0.1 0.0058 16.1 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EFX03665.1 - 0.021 14.2 0.0 0.17 11.2 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EFX03665.1 - 0.034 13.5 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 EFX03665.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Apq12 PF12716.7 EFX03666.1 - 2.1e-12 46.8 18.5 2.1e-12 46.8 18.5 1.7 2 0 0 2 2 2 1 Nuclear pore assembly and biogenesis Oxidored_q3 PF00499.20 EFX03666.1 - 0.015 15.0 0.3 0.026 14.2 0.3 1.4 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF2207 PF09972.9 EFX03666.1 - 0.069 11.9 0.5 0.075 11.8 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ING PF12998.7 EFX03667.1 - 5.2e-09 36.6 0.0 0.00022 21.8 0.0 2.4 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding Chitin_synth_2 PF03142.15 EFX03668.1 - 9e-231 767.0 0.3 1.3e-230 766.6 0.3 1.1 1 0 0 1 1 1 1 Chitin synthase DEK_C PF08766.11 EFX03668.1 - 6.5e-16 58.0 0.4 3.1e-15 55.8 0.7 2.0 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EFX03668.1 - 1.1e-14 54.8 6.0 1.2e-14 54.7 4.1 2.1 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFX03668.1 - 2.4e-12 47.3 0.0 6.1e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 EFX03668.1 - 1.2e-09 38.1 0.2 1.1e-05 25.5 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Myosin_head PF00063.21 EFX03668.1 - 1.1e-07 30.5 0.0 6.4e-07 28.0 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Glyco_transf_21 PF13506.6 EFX03668.1 - 8.4e-05 22.1 0.0 0.0055 16.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EFX03668.1 - 0.001 18.9 0.0 0.049 13.4 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 YwiC PF14256.6 EFX03668.1 - 4.2 7.7 10.8 3.3 8.0 1.4 2.9 2 0 0 2 2 2 0 YwiC-like protein INO80_Ies4 PF08193.11 EFX03669.1 - 9.8e-73 245.1 13.7 9.8e-73 245.1 13.7 1.5 2 0 0 2 2 2 1 INO80 complex subunit Ies4 zf-CCHC_4 PF14392.6 EFX03670.1 - 0.00014 21.5 10.6 0.19 11.5 0.3 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 EFX03670.1 - 1.6 8.9 29.0 0.11 12.6 1.1 4.6 5 0 0 5 5 5 0 Zinc knuckle Diphthami_syn_2 PF01902.17 EFX03671.1 - 1.8e-18 66.9 0.0 2.3e-15 56.7 0.0 2.9 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EFX03671.1 - 2.5e-09 37.2 0.2 9.8e-05 22.4 0.0 4.3 3 1 0 3 3 3 3 Endoribonuclease L-PSP Fungal_trans PF04082.18 EFX03672.1 - 2.1e-10 40.1 0.0 4e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFX03672.1 - 3.8e-08 33.4 7.7 0.0038 17.6 0.2 3.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFX03672.1 - 2.8e-07 30.7 7.7 7.1e-06 26.2 2.7 3.1 2 0 0 2 2 2 1 Zinc-finger double domain Zn_clus PF00172.18 EFX03672.1 - 2.9e-06 27.3 8.5 2.9e-06 27.3 8.5 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EFX03672.1 - 0.00085 20.0 13.8 0.016 16.0 1.9 3.6 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.7 EFX03672.1 - 0.0027 18.0 4.3 0.076 13.4 1.9 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFX03672.1 - 0.0094 16.2 2.2 3.3 8.1 1.1 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding Spt46 PF17734.1 EFX03672.1 - 0.012 15.5 0.7 0.025 14.4 0.6 1.6 1 1 0 1 1 1 0 Spermatogenesis-associated protein 46 zf-C2HC_2 PF13913.6 EFX03672.1 - 0.051 13.5 4.9 0.72 9.8 0.2 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 EFX03672.1 - 0.3 11.1 13.6 0.052 13.6 0.9 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger LIM PF00412.22 EFX03672.1 - 0.61 10.3 4.8 1.5 9.1 4.8 1.6 1 0 0 1 1 1 0 LIM domain zf-Di19 PF05605.12 EFX03672.1 - 1.4 9.3 6.5 36 4.8 7.2 2.4 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding CAML PF14963.6 EFX03673.1 - 1.7 8.7 5.8 2 8.4 5.2 1.4 1 1 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand GFO_IDH_MocA PF01408.22 EFX03674.1 - 1.3e-21 77.7 0.0 2.1e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFX03674.1 - 1.1e-07 31.8 0.0 3.5e-07 30.2 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EFX03674.1 - 5.2e-05 23.9 0.1 9.1e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFX03674.1 - 0.033 14.4 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF3602 PF12223.8 EFX03675.1 - 2.7e-15 56.7 13.7 1.7e-13 50.9 3.8 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) AFOR_N PF02730.15 EFX03675.1 - 0.25 11.2 0.2 0.25 11.2 0.2 2.8 2 1 1 3 3 3 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain F-box PF00646.33 EFX03676.1 - 1.5e-06 28.0 0.1 3.8e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFX03676.1 - 9.9e-06 25.4 0.0 1.9e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box-like_2 PF13013.6 EFX03676.1 - 0.0015 18.5 0.0 0.0039 17.1 0.0 1.7 1 0 0 1 1 1 1 F-box-like domain Gln-synt_C PF00120.24 EFX03677.1 - 1.4e-71 241.3 0.0 2e-71 240.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EFX03677.1 - 4e-15 56.4 0.1 1.4e-14 54.5 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Pyr_redox_2 PF07992.14 EFX03678.1 - 3e-27 95.6 0.1 1.6e-26 93.2 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX03678.1 - 5.3e-15 55.7 2.5 1.1e-12 48.3 0.2 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX03678.1 - 5.8e-05 22.5 0.2 0.0006 19.2 0.1 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX03678.1 - 0.00098 18.8 1.2 1.4 8.4 0.1 2.9 3 0 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EFX03678.1 - 0.0043 16.2 0.2 0.0067 15.6 0.2 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFX03678.1 - 0.0078 16.4 0.5 1.4 9.2 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EFX03678.1 - 0.0081 16.2 4.1 5.5 7.0 0.0 3.5 4 0 0 4 4 4 2 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EFX03678.1 - 0.014 15.8 0.1 0.16 12.4 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EFX03678.1 - 0.016 14.4 1.3 1.7 7.8 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EFX03678.1 - 0.029 13.4 1.8 0.051 12.6 0.2 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein CBM_10 PF02013.16 EFX03678.1 - 0.17 12.4 0.1 0.36 11.3 0.1 1.4 1 0 0 1 1 1 0 Cellulose or protein binding domain Trp_halogenase PF04820.14 EFX03678.1 - 0.38 9.6 1.5 18 4.0 0.2 2.9 3 0 0 3 3 3 0 Tryptophan halogenase HI0933_like PF03486.14 EFX03678.1 - 0.38 9.4 2.2 1.1 7.9 0.2 2.5 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 EFX03678.1 - 0.42 9.6 2.4 8 5.4 0.3 3.2 3 1 1 4 4 4 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EFX03678.1 - 0.45 9.8 5.0 1 8.6 0.3 2.8 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EFX03678.1 - 4.3 6.6 6.5 2.9 7.1 0.1 2.6 2 1 1 3 3 3 0 FAD dependent oxidoreductase Oxysterol_BP PF01237.18 EFX03679.1 - 3.8e-39 134.6 2.3 3.1e-38 131.6 0.0 3.6 2 1 0 2 2 2 1 Oxysterol-binding protein SET PF00856.28 EFX03679.1 - 5.5e-12 46.4 0.0 6.8e-10 39.6 0.0 2.7 2 0 0 2 2 2 1 SET domain Asp_Arg_Hydrox PF05118.15 EFX03679.1 - 0.11 12.4 0.4 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Aspartyl/Asparaginyl beta-hydroxylase DUF5549 PF17703.1 EFX03679.1 - 0.15 11.7 0.0 0.15 11.7 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5549) Peptidase_S49_N PF08496.10 EFX03679.1 - 3.3 7.7 6.2 21 5.1 1.8 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Radical_SAM PF04055.21 EFX03680.1 - 9.6e-06 26.1 0.0 2.4e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily LAM_C PF12544.8 EFX03680.1 - 0.00014 22.0 0.0 0.00037 20.7 0.0 1.7 1 0 0 1 1 1 1 Lysine-2,3-aminomutase Fer4_14 PF13394.6 EFX03680.1 - 0.054 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain Frankia_peptide PF14407.6 EFX03681.1 - 0.1 12.6 0.8 1.5 8.8 0.0 2.7 3 0 0 3 3 3 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. GLTT PF01744.20 EFX03683.1 - 9.4e-07 28.4 3.3 1.7e-06 27.6 3.3 1.4 1 0 0 1 1 1 1 GLTT repeat (6 copies) ECH_2 PF16113.5 EFX03685.1 - 1.9e-125 418.8 0.0 2.3e-125 418.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFX03685.1 - 1.4e-25 90.1 0.0 5.4e-25 88.2 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase SR-25 PF10500.9 EFX03685.1 - 0.14 11.8 0.3 0.33 10.5 0.1 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AAA_11 PF13086.6 EFX03686.1 - 4.3e-55 187.3 0.0 6.4e-55 186.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EFX03686.1 - 1.4e-53 181.5 0.0 2.1e-53 180.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX03686.1 - 8e-13 48.5 4.5 3.1e-10 40.1 4.5 3.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFX03686.1 - 1.9e-09 37.6 0.5 0.11 12.3 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EFX03686.1 - 1.2e-08 35.4 0.0 6.1e-08 33.1 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EFX03686.1 - 0.0012 18.5 3.0 0.012 15.2 0.1 3.0 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 EFX03686.1 - 0.0025 18.1 0.1 0.017 15.4 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX03686.1 - 0.0027 18.1 1.1 0.013 15.9 1.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EFX03686.1 - 0.0027 17.0 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 EFX03686.1 - 0.0073 16.2 0.0 0.048 13.5 0.0 2.2 2 0 0 2 2 2 1 Helicase UvrD-helicase PF00580.21 EFX03686.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_24 PF13479.6 EFX03686.1 - 0.014 15.1 0.0 0.18 11.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 EFX03686.1 - 0.015 15.1 0.0 0.048 13.5 0.0 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain IstB_IS21 PF01695.17 EFX03686.1 - 0.016 15.0 0.1 0.087 12.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA PF00004.29 EFX03686.1 - 0.024 15.1 0.0 0.26 11.7 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PIF1 PF05970.14 EFX03686.1 - 0.024 13.8 0.0 0.42 9.7 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase NTPase_1 PF03266.15 EFX03686.1 - 0.027 14.4 0.5 3.6 7.5 0.1 2.7 2 1 0 2 2 2 0 NTPase AAA_33 PF13671.6 EFX03686.1 - 0.034 14.3 0.2 0.27 11.4 0.1 2.6 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EFX03686.1 - 0.035 13.0 0.0 0.077 11.9 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ResIII PF04851.15 EFX03686.1 - 0.055 13.5 0.0 0.22 11.5 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CobA_CobO_BtuR PF02572.15 EFX03686.1 - 0.069 13.4 0.0 7.9 6.7 0.0 2.5 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP TRAPP PF04051.16 EFX03687.1 - 7.8e-35 119.7 0.0 9.1e-35 119.5 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PNGaseA PF12222.8 EFX03687.1 - 0.051 12.4 0.0 0.059 12.2 0.0 1.1 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Actin PF00022.19 EFX03688.1 - 1.1e-123 412.9 0.0 4.2e-123 411.0 0.0 1.7 1 1 0 1 1 1 1 Actin Peptidase_S41 PF03572.18 EFX03689.1 - 0.0091 15.6 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 Transp_cyt_pur PF02133.15 EFX03690.1 - 1.8e-34 119.3 31.7 3.9e-33 114.9 31.1 2.1 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin RHD3 PF05879.12 EFX03691.1 - 0 1045.5 0.0 0 1045.2 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EFX03691.1 - 2.8e-09 36.6 0.1 4.6e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EFX03691.1 - 4.4e-06 26.9 0.0 8.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EFX03691.1 - 5.2e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EFX03691.1 - 0.00056 20.2 0.1 0.0025 18.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EFX03691.1 - 0.024 13.9 0.1 0.04 13.2 0.1 1.3 1 0 0 1 1 1 0 Septin DUF3693 PF12472.8 EFX03691.1 - 0.12 12.0 0.0 0.12 12.0 0.0 2.7 4 0 0 4 4 4 0 Phage related protein Mito_carr PF00153.27 EFX03693.1 - 5.2e-51 170.5 2.3 1.7e-20 72.7 0.2 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein TAFII55_N PF04658.13 EFX03694.1 - 6.1e-48 162.6 0.0 1.2e-47 161.6 0.0 1.5 1 0 0 1 1 1 1 TAFII55 protein conserved region FAM76 PF16046.5 EFX03694.1 - 0.059 12.7 1.4 0.12 11.8 1.4 1.4 1 0 0 1 1 1 0 FAM76 protein RRN3 PF05327.11 EFX03694.1 - 1.6 7.2 13.0 2.7 6.4 13.0 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PDDEXK_6 PF04720.12 EFX03694.1 - 1.9 8.4 4.5 3.8 7.4 4.5 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function CybS PF05328.12 EFX03695.1 - 5.1e-48 162.1 0.0 6.4e-48 161.8 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit GFA PF04828.14 EFX03696.1 - 2.1e-22 79.2 0.0 3.1e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EFX03696.1 - 0.12 12.4 2.9 1 9.5 0.2 2.4 2 1 0 2 2 2 0 Double zinc ribbon DUF2461 PF09365.10 EFX03697.1 - 3.2e-74 249.4 0.0 5.2e-74 248.7 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) NOA36 PF06524.12 EFX03697.1 - 8.5 5.6 8.7 14 4.8 8.7 1.4 1 0 0 1 1 1 0 NOA36 protein bZIP_1 PF00170.21 EFX03698.1 - 1.3e-05 25.2 4.5 1.3e-05 25.2 4.5 1.5 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFX03698.1 - 0.031 14.4 4.4 0.031 14.4 4.4 1.6 2 0 0 2 2 2 0 Basic region leucine zipper RNA_pol_Rpb4 PF03874.16 EFX03699.1 - 1.4e-20 73.8 0.0 1.7e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 MFS_1 PF07690.16 EFX03700.1 - 2.7e-28 98.9 30.5 1.4e-27 96.5 26.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX03700.1 - 0.0067 14.9 1.9 0.011 14.2 1.9 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_6 PF07332.11 EFX03700.1 - 0.35 10.9 11.0 1.2 9.2 0.0 3.8 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Fungal_trans PF04082.18 EFX03701.1 - 4.1e-13 49.0 1.9 1.4e-12 47.2 1.9 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain AA_permease_2 PF13520.6 EFX03702.1 - 5.4e-64 216.6 44.2 6.9e-64 216.2 44.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX03702.1 - 5.5e-13 48.3 39.3 7.8e-13 47.8 39.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3176 PF11374.8 EFX03702.1 - 0.091 13.0 0.9 2.3 8.4 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3176) TMEM237 PF15383.6 EFX03702.1 - 0.3 10.2 1.3 0.32 10.1 0.2 1.5 2 0 0 2 2 2 0 Transmembrane protein 237 adh_short_C2 PF13561.6 EFX03703.1 - 2.3e-27 96.0 2.2 5.1e-18 65.5 0.0 2.4 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX03703.1 - 8e-25 87.4 8.2 5.3e-13 48.9 3.4 2.7 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EFX03703.1 - 1.8e-09 37.8 0.5 1.8e-09 37.8 0.5 1.6 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EFX03703.1 - 0.021 14.0 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1682 PF07946.14 EFX03704.1 - 1.7e-111 372.6 2.6 1.9e-111 372.4 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF2985 PF11204.8 EFX03704.1 - 0.064 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) PreAtp-grasp PF18604.1 EFX03704.1 - 0.097 12.3 0.0 0.26 10.9 0.0 1.7 1 0 0 1 1 1 0 Pre ATP-grasp domain Ribosomal_L14 PF00238.19 EFX03705.1 - 3.7e-33 114.2 0.0 4.4e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e FAD_binding_8 PF08022.12 EFX03706.1 - 2.4e-22 79.1 0.0 4.7e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EFX03706.1 - 1.6e-21 77.1 0.0 2.9e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EFX03706.1 - 2.2e-21 76.3 8.8 2.2e-21 76.3 8.8 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EFX03706.1 - 0.039 14.3 0.0 0.086 13.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain LrgA PF03788.14 EFX03706.1 - 0.11 12.4 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 LrgA family DUF4780 PF16012.5 EFX03706.1 - 0.13 11.7 0.0 0.4 10.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4780) NAD_binding_1 PF00175.21 EFX03706.1 - 0.14 12.8 0.0 2.3 8.9 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain WD40 PF00400.32 EFX03707.1 - 8.4e-47 156.2 16.4 1.7e-09 38.1 0.5 8.4 8 1 0 8 8 8 6 WD domain, G-beta repeat GFO_IDH_MocA PF01408.22 EFX03707.1 - 8.7e-17 62.1 0.5 2.1e-16 60.8 0.5 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ANAPC4_WD40 PF12894.7 EFX03707.1 - 1.8e-08 34.6 0.2 0.0039 17.5 0.0 4.1 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX03707.1 - 0.00083 18.1 0.2 0.044 12.4 0.1 3.1 3 0 0 3 3 3 1 Nucleoporin Nup120/160 GFO_IDH_MocA_C PF02894.17 EFX03707.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Nucleoporin_N PF08801.11 EFX03707.1 - 0.088 11.5 0.0 0.89 8.2 0.0 2.2 2 0 0 2 2 2 0 Nup133 N terminal like LisH PF08513.11 EFX03707.1 - 0.19 11.7 0.1 1.1 9.3 0.1 2.2 2 0 0 2 2 2 0 LisH Glucan_synthase PF02364.15 EFX03708.1 - 0 1366.1 0.1 0 1364.7 0.0 1.8 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EFX03708.1 - 1.3e-41 141.9 0.7 5e-41 140.1 0.7 2.0 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 ETF_QO PF05187.13 EFX03710.1 - 8.5e-48 160.8 0.5 1.4e-47 160.1 0.5 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S NAD_binding_8 PF13450.6 EFX03710.1 - 3.3e-08 33.6 0.0 1.2e-07 31.8 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX03710.1 - 1.7e-06 27.9 3.0 0.00018 21.2 0.5 2.6 2 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX03710.1 - 4.7e-05 22.6 1.4 0.0051 16.0 0.8 2.4 1 1 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EFX03710.1 - 6.3e-05 22.3 0.0 0.0068 15.7 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EFX03710.1 - 6.9e-05 22.2 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX03710.1 - 0.00012 20.9 0.4 0.00018 20.4 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 EFX03710.1 - 0.0013 18.1 0.0 0.0025 17.2 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFX03710.1 - 0.0018 17.6 0.1 0.0031 16.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EFX03710.1 - 0.002 18.1 0.0 0.0051 16.8 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EFX03710.1 - 0.0056 16.0 0.4 0.0083 15.4 0.4 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX03710.1 - 0.0069 15.3 0.1 0.26 10.1 0.1 2.1 1 1 0 2 2 2 1 Tryptophan halogenase Fer4_7 PF12838.7 EFX03710.1 - 0.014 16.0 1.0 0.039 14.5 1.0 1.8 1 0 0 1 1 1 0 4Fe-4S dicluster domain AlaDh_PNT_C PF01262.21 EFX03710.1 - 0.034 13.5 0.0 0.06 12.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EFX03710.1 - 0.037 13.1 0.2 0.058 12.4 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 EFX03710.1 - 0.049 14.2 0.1 7.2 7.3 0.2 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX03710.1 - 0.075 12.3 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GIDA PF01134.22 EFX03710.1 - 0.094 11.8 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_2 PF12797.7 EFX03710.1 - 0.17 12.0 0.7 0.47 10.7 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain Gtr1_RagA PF04670.12 EFX03711.1 - 1.1e-67 227.8 0.2 1.3e-67 227.5 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFX03711.1 - 0.0063 16.0 0.0 0.0088 15.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFX03711.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Isochorismatase PF00857.20 EFX03713.1 - 3.7e-23 82.6 0.0 8.1e-23 81.5 0.0 1.5 1 1 0 1 1 1 1 Isochorismatase family CHORD PF04968.12 EFX03714.1 - 1.1e-48 163.8 18.8 2.3e-25 89.1 4.5 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 EFX03714.1 - 8.3e-10 39.6 0.1 1.3e-09 39.0 0.1 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.19 EFX03714.1 - 0.32 10.8 9.0 0.54 10.1 1.2 3.0 3 0 0 3 3 3 0 BTK motif DUF4835 PF16119.5 EFX03715.1 - 0.2 10.8 0.0 0.22 10.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4835) Peptidase_S8 PF00082.22 EFX03716.1 - 1.3e-47 162.6 3.2 2e-47 161.9 3.2 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EFX03716.1 - 1.8e-08 35.1 0.1 3.9e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Fn3-like domain DUF11 PF01345.18 EFX03716.1 - 0.036 14.3 1.8 0.19 12.0 1.8 2.2 1 0 0 1 1 1 0 Domain of unknown function DUF11 Peripla_BP_1 PF00532.21 EFX03716.1 - 0.068 12.6 0.0 0.68 9.3 0.0 2.0 2 0 0 2 2 2 0 Periplasmic binding proteins and sugar binding domain of LacI family Amidohydro_3 PF07969.11 EFX03717.1 - 3.2e-16 59.9 3.3 1.7e-11 44.2 0.1 3.0 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 EFX03717.1 - 3.1e-11 43.2 0.0 2.5e-09 36.9 0.0 2.6 2 0 0 2 2 2 2 Amidohydrolase family Ank_2 PF12796.7 EFX03718.1 - 2.8e-13 50.2 0.3 1.9e-08 34.8 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX03718.1 - 1.4e-12 47.8 0.7 7.3e-06 26.4 0.1 3.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFX03718.1 - 8.5e-10 38.6 7.7 0.0011 19.3 0.9 4.8 5 0 0 5 5 5 3 Ankyrin repeat DUF3328 PF11807.8 EFX03718.1 - 1.7e-09 37.8 0.3 3.1e-09 36.9 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Cu_amine_oxid PF01179.20 EFX03718.1 - 1.1e-08 34.5 0.0 1.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Ank_3 PF13606.6 EFX03718.1 - 1.4e-07 31.2 1.0 0.0069 16.8 0.1 4.9 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFX03718.1 - 0.00011 22.4 0.2 0.006 16.9 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Cu_amine_oxidN2 PF02727.16 EFX03718.1 - 0.0058 16.8 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain P16-Arc PF04699.14 EFX03719.1 - 4.9e-50 169.9 0.0 5.9e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Reovirus_Mu2 PF07781.11 EFX03719.1 - 0.13 10.6 0.0 0.17 10.2 0.0 1.2 1 0 0 1 1 1 0 Reovirus minor core protein Mu-2 PAP_assoc PF03828.19 EFX03720.1 - 1e-16 60.9 0.0 8.4e-11 41.9 0.0 2.5 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFX03720.1 - 1.6e-05 25.1 0.0 4.1e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFX03720.1 - 0.014 15.4 0.0 0.067 13.3 0.0 2.1 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase DWNN PF08783.11 EFX03721.1 - 6.7e-32 109.6 0.0 1.2e-31 108.8 0.0 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EFX03721.1 - 6e-09 35.6 5.6 1.3e-08 34.4 5.6 1.6 1 0 0 1 1 1 1 Zinc knuckle Med3 PF11593.8 EFX03721.1 - 1.9e-05 24.0 24.4 1.9e-05 24.0 24.4 2.5 3 0 0 3 3 2 1 Mediator complex subunit 3 fungal zf-CCHC PF00098.23 EFX03721.1 - 0.00055 19.9 0.9 0.0012 18.8 0.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EFX03721.1 - 0.0018 18.1 8.7 0.0018 18.1 8.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFX03721.1 - 0.017 15.3 10.0 0.051 13.7 10.0 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFX03721.1 - 0.018 15.3 7.0 0.041 14.2 7.0 1.6 1 0 0 1 1 1 0 Ring finger domain zf-CCHC_3 PF13917.6 EFX03721.1 - 0.021 14.7 0.5 0.063 13.3 0.5 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-RING_UBOX PF13445.6 EFX03721.1 - 0.029 14.4 7.1 0.058 13.4 7.1 1.5 1 0 0 1 1 1 0 RING-type zinc-finger U-box PF04564.15 EFX03721.1 - 0.049 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-RING_6 PF14835.6 EFX03721.1 - 0.059 13.3 1.2 0.1 12.5 1.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFX03721.1 - 0.069 12.9 6.0 0.16 11.8 6.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EFX03721.1 - 0.1 12.4 4.2 0.22 11.4 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.25 EFX03721.1 - 0.12 12.3 8.2 0.24 11.3 8.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 EFX03721.1 - 0.2 11.9 1.3 0.37 11.0 0.4 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger zf-RING_5 PF14634.6 EFX03721.1 - 0.34 10.9 12.3 0.027 14.4 6.7 2.0 2 0 0 2 2 2 0 zinc-RING finger domain CarboxypepD_reg PF13620.6 EFX03721.1 - 0.41 10.9 3.5 13 6.2 1.1 2.4 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain DUF572 PF04502.13 EFX03721.1 - 0.49 10.0 13.0 0.68 9.5 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Cullin PF00888.22 EFX03722.1 - 5.1e-25 88.2 0.3 9.1e-25 87.3 0.1 1.4 2 0 0 2 2 2 1 Cullin family ANAPC2 PF08672.11 EFX03722.1 - 1.2e-20 73.7 2.1 1.4e-20 73.5 0.4 2.1 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 Hydantoinase_A PF01968.18 EFX03722.1 - 0.074 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Glycolytic PF00274.19 EFX03722.1 - 0.14 10.8 0.0 0.28 9.9 0.0 1.4 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-I DUF2418 PF10332.9 EFX03724.1 - 7e-32 109.8 0.1 1.4e-31 108.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) DUF1180 PF06679.12 EFX03724.1 - 0.34 11.3 9.8 0.15 12.5 7.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) NIF PF03031.18 EFX03725.1 - 1.7e-28 99.4 1.8 1.4e-27 96.3 0.0 2.7 3 1 0 3 3 3 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EFX03725.1 - 6.6e-06 26.4 0.0 1.7e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFX03725.1 - 0.00017 21.5 0.0 0.00035 20.5 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain XPG_I PF00867.18 EFX03726.1 - 4.2e-23 81.5 0.0 8.7e-23 80.5 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EFX03726.1 - 1.6e-22 79.9 0.0 3.1e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EFX03726.1 - 4.3e-05 23.1 0.0 7.6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 EFX03726.1 - 0.038 14.6 0.0 0.079 13.6 0.0 1.5 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold TPR_2 PF07719.17 EFX03726.1 - 0.16 12.1 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat GWT1 PF06423.12 EFX03727.1 - 2.6 8.2 6.5 16 5.6 0.1 2.6 2 0 0 2 2 2 0 GWT1 Methyltransf_32 PF13679.6 EFX03728.1 - 5.9e-21 75.1 0.0 1.8e-20 73.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain DinB_2 PF12867.7 EFX03728.1 - 0.76 10.3 5.5 18 5.8 0.1 3.2 2 1 1 3 3 3 0 DinB superfamily Ecl1 PF12855.7 EFX03729.1 - 3.7e-37 129.2 17.4 3.7e-37 129.2 17.4 2.0 2 0 0 2 2 2 1 ECL1/2/3 zinc binding proteins zf-FLZ PF04570.14 EFX03729.1 - 0.029 13.8 3.9 0.066 12.7 3.9 1.6 1 0 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 zf-MYND PF01753.18 EFX03729.1 - 0.12 12.5 1.0 0.24 11.5 1.0 1.5 1 0 0 1 1 1 0 MYND finger PLATZ PF04640.14 EFX03729.1 - 0.16 12.6 0.9 0.3 11.7 0.9 1.5 1 0 0 1 1 1 0 PLATZ transcription factor DUF2256 PF10013.9 EFX03729.1 - 1.8 8.8 5.6 17 5.7 5.6 2.2 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) AA_permease PF00324.21 EFX03730.1 - 1.4e-107 360.3 36.5 1e-106 357.5 36.5 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX03730.1 - 8.9e-22 77.5 36.4 1.2e-21 77.1 36.4 1.1 1 0 0 1 1 1 1 Amino acid permease Nucleos_tra2_C PF07662.13 EFX03730.1 - 0.59 9.9 9.8 1.4 8.7 0.6 2.5 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter C-terminus DUF2235 PF09994.9 EFX03731.1 - 4.2e-66 223.2 1.8 1.2e-40 139.7 0.0 2.1 2 0 0 2 2 2 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) Mago-bind PF09282.10 EFX03732.1 - 6.1e-13 48.4 4.2 1.3e-12 47.3 4.2 1.6 1 0 0 1 1 1 1 Mago binding SR-25 PF10500.9 EFX03732.1 - 0.0025 17.5 1.7 0.0033 17.1 1.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF3720 PF12517.8 EFX03732.1 - 0.025 15.5 10.2 0.18 12.7 7.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3720) PfkB PF00294.24 EFX03733.1 - 7.2e-11 41.9 0.3 2.1e-07 30.6 1.2 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase DUF3018 PF11455.8 EFX03733.1 - 0.14 12.1 0.0 0.14 12.1 0.0 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3018) IBR PF01485.21 EFX03734.1 - 3e-14 53.0 29.7 3e-07 30.5 9.0 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFX03734.1 - 7.5e-07 29.4 3.6 7.5e-07 29.4 3.6 4.1 4 1 0 4 4 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EFX03734.1 - 3.8e-05 23.6 5.0 3.8e-05 23.6 5.0 3.3 3 1 0 3 3 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFX03734.1 - 0.00012 22.0 4.4 0.00012 22.0 4.4 3.4 3 0 0 3 3 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFX03734.1 - 0.0003 20.9 5.4 0.0003 20.9 5.4 3.5 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EFX03734.1 - 0.00057 19.6 3.2 0.00057 19.6 3.2 3.5 4 0 0 4 4 3 1 RING-like zinc finger zf-CCCH PF00642.24 EFX03734.1 - 0.00085 19.2 4.6 0.00085 19.2 4.6 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.25 EFX03734.1 - 0.0034 17.2 4.8 0.0034 17.2 4.8 3.7 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX03734.1 - 0.0036 17.1 3.3 0.0036 17.1 3.3 3.9 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 EFX03734.1 - 0.005 16.6 4.4 0.005 16.6 4.4 2.1 2 0 0 2 2 2 1 CCCH-type zinc finger RRM_1 PF00076.22 EFX03734.1 - 0.006 16.4 0.0 0.061 13.2 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4139 PF13598.6 EFX03736.1 - 9.8e-30 103.8 0.0 4.6e-29 101.6 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 EFX03736.1 - 2.1e-23 82.6 0.8 2.1e-23 82.6 0.8 3.2 2 1 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) LCD1 PF09798.9 EFX03736.1 - 0.33 9.4 5.2 0.48 8.9 5.2 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein S1-P1_nuclease PF02265.16 EFX03737.1 - 1.1e-66 225.3 0.0 1.3e-66 225.1 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease WD40 PF00400.32 EFX03738.1 - 8.7e-24 83.4 4.9 1e-08 35.7 0.3 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX03738.1 - 2.7e-12 46.8 0.1 0.00019 21.7 0.0 4.6 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EFX03738.1 - 0.00054 19.1 0.4 0.078 12.0 0.3 2.1 1 1 1 2 2 2 2 Coatomer WD associated region Nup160 PF11715.8 EFX03738.1 - 0.00093 18.0 0.1 0.005 15.5 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 EFX03738.1 - 0.019 14.3 0.0 1.8 7.8 0.0 2.6 2 1 0 3 3 3 0 WD40-like domain PQQ_2 PF13360.6 EFX03738.1 - 0.021 14.4 0.3 0.075 12.6 0.4 1.8 1 1 1 2 2 2 0 PQQ-like domain Nucleoporin_N PF08801.11 EFX03738.1 - 0.14 10.8 0.1 0.34 9.6 0.1 1.6 1 1 0 1 1 1 0 Nup133 N terminal like VTC PF09359.10 EFX03739.1 - 1e-94 317.0 1.0 1.4e-94 316.6 0.0 1.7 2 0 0 2 2 2 1 VTC domain DUF202 PF02656.15 EFX03739.1 - 6.5e-13 48.9 1.1 1.3e-12 48.0 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 EFX03739.1 - 5.9e-11 42.9 10.9 5.3e-05 23.3 0.0 4.1 3 1 1 4 4 4 3 SPX domain CENP-B_dimeris PF09026.10 EFX03739.1 - 8.3 6.9 8.6 34 4.9 2.8 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3533 PF12051.8 EFX03740.1 - 2.8e-75 253.6 19.4 3.2e-75 253.4 19.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Cg6151-P PF10233.9 EFX03741.1 - 1.8e-43 147.4 15.6 2.2e-43 147.2 15.6 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Glutaredoxin PF00462.24 EFX03742.1 - 2.8e-17 62.7 0.0 5e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin NAF PF03822.14 EFX03742.1 - 0.019 15.2 0.0 0.56 10.4 0.0 2.5 2 0 0 2 2 2 0 NAF domain MIS13 PF08202.11 EFX03743.1 - 3.1e-57 194.2 0.0 5.3e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DUF1192 PF06698.11 EFX03743.1 - 8.4 6.5 8.3 12 6.1 2.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) ATP-synt_D PF01813.17 EFX03745.1 - 3e-70 236.1 1.2 3e-70 236.1 1.2 1.4 2 0 0 2 2 2 1 ATP synthase subunit D GAGBD PF16828.5 EFX03745.1 - 0.029 14.5 3.5 0.56 10.3 5.1 2.0 2 0 0 2 2 2 0 GAG-binding domain on surface antigen Ribosomal_L6e PF01159.19 EFX03745.1 - 0.37 11.3 4.8 0.97 10.0 4.8 1.6 1 0 0 1 1 1 0 Ribosomal protein L6e Sec62 PF03839.16 EFX03745.1 - 0.7 9.4 6.0 1 8.8 6.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 ATP-synt_E PF05680.12 EFX03745.1 - 4.2 7.8 8.7 10 6.5 8.7 1.6 1 0 0 1 1 1 0 ATP synthase E chain Vta1 PF04652.16 EFX03746.1 - 8.6e-52 175.0 1.6 8.6e-52 175.0 1.6 1.5 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EFX03746.1 - 3.5e-16 58.6 0.1 3.5e-16 58.6 0.1 1.8 2 0 0 2 2 2 1 Vta1 C-terminal domain GAF_2 PF13185.6 EFX03746.1 - 0.06 13.6 0.2 0.18 12.1 0.2 1.9 1 1 0 1 1 1 0 GAF domain Pyr_redox_2 PF07992.14 EFX03747.1 - 6.4e-48 163.5 1.2 7.6e-48 163.2 1.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX03747.1 - 2.2e-18 66.6 0.5 6.2e-15 55.5 0.1 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX03747.1 - 6.3e-15 55.2 0.1 3.2e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EFX03747.1 - 2.5e-05 24.6 0.0 0.029 14.8 0.0 2.5 2 1 0 2 2 2 2 Putative NAD(P)-binding K_oxygenase PF13434.6 EFX03747.1 - 6.1e-05 22.3 0.2 0.0067 15.6 0.0 3.1 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EFX03747.1 - 7.9e-05 22.0 0.8 0.0008 18.7 0.1 2.5 2 1 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EFX03747.1 - 0.00037 20.7 0.3 0.049 13.9 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 EFX03747.1 - 0.00062 19.8 0.2 6.7 6.8 0.0 3.4 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 EFX03747.1 - 0.001 18.7 3.1 0.76 9.3 0.0 3.2 2 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX03747.1 - 0.0048 16.0 3.6 0.036 13.2 0.3 3.0 2 1 0 3 3 3 1 FAD binding domain GIDA PF01134.22 EFX03747.1 - 0.0061 15.7 6.2 0.068 12.2 0.4 3.7 3 1 0 4 4 4 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFX03747.1 - 0.0061 16.0 0.5 0.016 14.6 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFX03747.1 - 0.0075 15.6 0.8 3.2 6.9 0.1 2.7 2 1 1 3 3 3 2 FAD binding domain HI0933_like PF03486.14 EFX03747.1 - 0.018 13.8 0.3 0.95 8.1 0.2 2.9 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_9 PF13454.6 EFX03747.1 - 0.047 13.7 0.2 1.2 9.1 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EFX03747.1 - 0.057 12.3 0.1 0.69 8.7 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Aldedh PF00171.22 EFX03748.1 - 1.7e-07 30.1 15.8 9.9e-05 21.0 12.0 2.9 1 1 0 2 2 2 2 Aldehyde dehydrogenase family F-box-like PF12937.7 EFX03750.1 - 1.1e-05 25.2 0.1 2.3e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX03750.1 - 0.071 13.0 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 F-box domain HSP70 PF00012.20 EFX03751.1 - 5.6e-265 880.2 13.8 6.4e-265 880.0 13.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFX03751.1 - 2.6e-16 59.4 1.6 1.1e-14 54.0 0.4 2.2 2 0 0 2 2 2 2 MreB/Mbl protein TcdA_TcdB PF12919.7 EFX03751.1 - 0.0091 15.3 0.1 0.02 14.2 0.1 1.5 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain DDR PF08841.10 EFX03751.1 - 0.024 13.7 0.4 0.12 11.4 0.2 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 EFX03751.1 - 0.035 13.4 3.3 0.11 11.7 0.1 2.8 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase FtsA PF14450.6 EFX03751.1 - 0.097 13.1 6.6 7.8 7.0 0.1 3.7 3 2 0 3 3 3 0 Cell division protein FtsA FGGY_C PF02782.16 EFX03751.1 - 0.17 11.6 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Borrelia_orfA PF02414.15 EFX03751.1 - 1.6 8.3 7.2 2.6 7.6 0.4 2.4 2 0 0 2 2 2 0 Borrelia ORF-A Ribonuclease_T2 PF00445.18 EFX03752.1 - 1.1e-41 143.1 0.6 1.8e-41 142.4 0.6 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family RRM_1 PF00076.22 EFX03753.1 - 2.7e-22 78.4 0.1 3.6e-10 39.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EamA PF00892.20 EFX03754.1 - 3.6e-22 79.0 19.7 3.4e-13 49.9 2.3 2.4 2 0 0 2 2 2 2 EamA-like transporter family Aft1_HRR PF11787.8 EFX03755.1 - 2.8e-24 86.1 4.1 2.8e-24 86.1 4.1 4.1 4 2 0 4 4 4 1 Aft1 HRR domain Aft1_HRA PF11786.8 EFX03755.1 - 3.6e-22 78.5 9.2 3.6e-22 78.5 9.2 2.7 2 0 0 2 2 2 1 Aft1 HRA domain Aft1_OSA PF11785.8 EFX03755.1 - 4.3e-21 75.1 10.7 4.3e-21 75.1 10.7 4.8 6 0 0 6 6 6 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EFX03755.1 - 9.1e-13 48.1 5.1 1.7e-12 47.3 5.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFX03755.1 - 1.3e-05 25.2 7.0 2.8e-05 24.1 7.0 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFX03755.1 - 0.0031 18.0 2.6 0.0031 18.0 2.6 1.9 1 1 1 2 2 2 1 bZIP Maf transcription factor Macoilin PF09726.9 EFX03755.1 - 0.044 12.4 5.3 0.084 11.4 5.3 1.4 1 0 0 1 1 1 0 Macoilin family HALZ PF02183.18 EFX03755.1 - 0.14 12.4 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper Calc_CGRP_IAPP PF00214.19 EFX03756.1 - 0.012 15.9 0.0 0.024 15.0 0.0 1.5 1 1 0 1 1 1 0 Calcitonin / CGRP / IAPP family Abhydrolase_3 PF07859.13 EFX03757.1 - 5.4e-50 170.2 3.1 1.8e-43 148.9 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX03757.1 - 6.2e-06 25.8 0.0 2.3e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EFX03757.1 - 0.00078 18.4 0.1 0.0066 15.4 0.1 2.0 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 EFX03757.1 - 0.00087 18.8 0.1 0.0017 17.9 0.1 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase Mog1 PF04603.12 EFX03758.1 - 2.4e-39 134.8 0.0 2.9e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Methyltransf_23 PF13489.6 EFX03759.1 - 2.8e-10 40.3 0.0 4.4e-10 39.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03759.1 - 0.0021 18.7 0.0 0.0064 17.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03759.1 - 0.0024 18.5 0.0 0.0047 17.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03759.1 - 0.0098 16.6 0.0 0.073 13.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain PhyH PF05721.13 EFX03760.1 - 2.3e-35 122.8 0.2 3.5e-35 122.2 0.2 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) RhoGAP PF00620.27 EFX03761.1 - 7.1e-11 42.1 0.0 1.8e-10 40.8 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain Podoplanin PF05808.11 EFX03763.1 - 5.6 7.1 8.7 19 5.3 8.7 1.9 1 1 0 1 1 1 0 Podoplanin Fungal_trans PF04082.18 EFX03764.1 - 5e-19 68.4 0.1 7.4e-19 67.8 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFX03764.1 - 3.3e-10 39.8 11.2 1.5e-05 25.2 4.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX03764.1 - 1.9e-07 31.3 7.3 0.00036 21.1 3.2 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX03764.1 - 1.4e-06 28.5 7.2 0.00015 22.0 2.3 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2HC_2 PF13913.6 EFX03764.1 - 0.00078 19.3 2.8 0.0019 18.1 2.8 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EFX03764.1 - 0.029 14.6 0.2 0.087 13.1 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EFX03764.1 - 0.14 12.5 0.8 0.3 11.4 0.8 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 EFX03764.1 - 0.21 11.9 2.4 3.7 7.9 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon Zn-C2H2_12 PF18112.1 EFX03764.1 - 0.25 11.8 2.4 0.71 10.4 2.4 1.8 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain ADK_lid PF05191.14 EFX03764.1 - 0.28 11.2 2.4 0.55 10.3 2.4 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.10 EFX03764.1 - 0.38 10.9 4.3 2.7 8.2 0.5 2.3 1 1 2 3 3 3 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 EFX03764.1 - 0.51 10.1 7.8 1.1 9.1 1.0 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 EFX03764.1 - 0.62 10.1 4.1 1.3 9.1 4.1 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain ATPase-cat_bd PF12156.8 EFX03764.1 - 0.89 10.3 2.3 1.7 9.5 2.3 1.4 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase zf-C2H2_6 PF13912.6 EFX03764.1 - 1 9.5 5.5 18 5.5 2.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-FPG_IleRS PF06827.14 EFX03764.1 - 1.2 9.1 6.5 0.55 10.1 0.8 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-C2HE PF16278.5 EFX03764.1 - 1.5 9.3 5.3 20 5.7 5.3 2.4 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 EFX03764.1 - 2.4 8.2 8.6 4.3 7.4 0.8 3.2 2 1 1 3 3 3 0 BED zinc finger Lar_restr_allev PF14354.6 EFX03764.1 - 2.9 8.3 4.3 0.39 11.1 0.1 1.7 2 0 0 2 2 1 0 Restriction alleviation protein Lar Dala_Dala_lig_C PF07478.13 EFX03765.1 - 9.9e-11 41.5 0.0 2.9e-10 40.0 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 EFX03765.1 - 5.8e-05 22.7 0.0 0.00011 21.8 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 EFX03765.1 - 0.00031 20.8 0.0 0.0014 18.7 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EFX03765.1 - 0.0014 18.2 0.0 0.005 16.4 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFX03765.1 - 0.0047 16.7 0.0 0.0067 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ApbA_C PF08546.11 EFX03765.1 - 0.038 14.2 0.0 0.1 12.8 0.0 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal Methyltransf_23 PF13489.6 EFX03766.1 - 3.1e-16 59.6 0.0 4.2e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03766.1 - 1.3e-10 41.9 0.0 3.7e-08 33.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03766.1 - 2.6e-10 40.8 0.0 6.4e-09 36.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03766.1 - 8.5e-07 29.7 0.0 7.3e-05 23.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX03766.1 - 0.00034 20.0 0.0 0.079 12.3 0.0 2.2 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFX03766.1 - 0.0048 16.5 0.0 0.016 14.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EFX03766.1 - 0.0059 15.9 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EFX03766.1 - 0.0097 15.7 0.0 0.38 10.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFX03766.1 - 0.042 13.7 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_PK PF05891.12 EFX03766.1 - 0.16 11.4 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase ABC_tran PF00005.27 EFX03767.1 - 1e-53 181.5 0.0 2e-29 102.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFX03767.1 - 1.6e-49 169.1 28.4 1e-28 100.8 12.8 4.1 3 1 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFX03767.1 - 3.2e-09 36.5 0.9 0.004 16.6 0.0 4.0 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFX03767.1 - 1.3e-08 35.6 0.1 7.5e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EFX03767.1 - 1.2e-06 28.5 0.1 0.0068 16.2 0.0 3.5 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFX03767.1 - 3.8e-06 26.9 0.1 0.078 12.9 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFX03767.1 - 1.5e-05 25.0 2.5 0.012 15.7 0.0 3.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFX03767.1 - 2.4e-05 24.8 0.0 0.34 11.3 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EFX03767.1 - 4.2e-05 23.2 0.4 0.17 11.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFX03767.1 - 0.00027 21.2 0.0 0.77 10.0 0.0 3.0 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EFX03767.1 - 0.00029 20.6 0.0 0.19 11.4 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein T2SSE PF00437.20 EFX03767.1 - 0.0003 19.9 0.0 0.013 14.6 0.2 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 EFX03767.1 - 0.00088 18.9 0.1 0.57 9.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFX03767.1 - 0.0045 17.4 0.3 6.9 7.1 0.0 3.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EFX03767.1 - 0.0056 16.8 1.2 0.27 11.3 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain Zeta_toxin PF06414.12 EFX03767.1 - 0.011 15.1 0.2 5.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 EFX03767.1 - 0.011 15.4 1.0 2.6 7.7 0.2 2.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EFX03767.1 - 0.04 13.2 0.4 4.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EFX03767.1 - 0.042 13.4 0.1 12 5.3 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 EFX03767.1 - 0.048 13.7 0.4 6 6.9 0.0 2.9 2 0 0 2 2 2 0 Dynamin family RNA_helicase PF00910.22 EFX03767.1 - 0.053 13.9 0.1 20 5.6 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 EFX03767.1 - 0.058 13.9 1.0 6 7.4 0.2 2.9 2 1 0 2 2 2 0 AAA domain ResIII PF04851.15 EFX03767.1 - 0.085 12.8 0.0 20 5.1 0.1 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit NACHT PF05729.12 EFX03767.1 - 0.12 12.3 1.7 3.4 7.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain Pox_A32 PF04665.12 EFX03767.1 - 0.15 11.5 0.3 4 6.8 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_15 PF13175.6 EFX03767.1 - 0.17 11.6 0.0 3.1 7.4 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EFX03767.1 - 0.17 11.2 0.5 5.2 6.4 0.2 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family PhoH PF02562.16 EFX03767.1 - 0.17 11.3 0.5 19 4.6 0.1 2.5 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 EFX03767.1 - 0.18 11.7 0.0 0.72 9.7 0.0 2.0 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EFX03767.1 - 0.2 11.6 0.7 26 4.8 0.1 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EFX03767.1 - 0.24 11.1 1.0 22 4.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EFX03767.1 - 0.31 10.6 4.3 0.25 10.9 0.6 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PDZ_6 PF17820.1 EFX03769.1 - 0.00045 20.0 0.1 0.00093 19.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EFX03769.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 PDZ domain UDPGP PF01704.18 EFX03770.1 - 7e-44 150.1 0.0 1.1e-43 149.4 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EFX03770.1 - 0.059 13.7 2.5 0.21 12.0 2.5 2.1 1 1 0 1 1 1 0 MobA-like NTP transferase domain Isochorismatase PF00857.20 EFX03771.1 - 1.5e-28 100.1 0.1 3.4e-28 99.0 0.1 1.6 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans PF04082.18 EFX03771.1 - 2.6e-15 56.2 0.0 4e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03771.1 - 0.015 15.4 7.6 0.015 15.4 7.6 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain HypA PF01155.19 EFX03771.1 - 0.063 13.3 4.3 0.16 12.0 4.3 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Epimerase PF01370.21 EFX03772.1 - 1.1e-09 38.1 0.2 2.5e-09 37.0 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX03772.1 - 1.7e-08 34.3 0.0 6.9e-08 32.3 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFX03772.1 - 0.00017 21.5 0.2 0.00032 20.7 0.2 1.5 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFX03772.1 - 0.15 11.5 2.6 3.2 7.2 0.3 2.5 2 1 0 2 2 2 0 short chain dehydrogenase RRM_1 PF00076.22 EFX03773.1 - 5.7e-15 54.9 0.0 1e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFX03773.1 - 6.5e-05 22.7 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif FoP_duplication PF13865.6 EFX03773.1 - 0.0017 18.8 2.0 0.0017 18.8 2.0 2.9 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 DUF3433 PF11915.8 EFX03775.1 - 1.4e-40 137.7 14.3 3.6e-20 72.2 2.1 3.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) DUF2569 PF10754.9 EFX03775.1 - 0.037 14.5 1.0 0.34 11.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) zf-UBR PF02207.20 EFX03776.1 - 1.8e-17 63.3 15.7 1.8e-17 63.3 15.7 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EFX03776.1 - 5.2e-06 26.2 0.0 1.2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS FAD_binding_4 PF01565.23 EFX03777.1 - 2.1e-22 79.3 1.0 4.8e-22 78.2 0.8 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EFX03777.1 - 0.00019 21.5 0.0 0.0004 20.4 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like DUF1365 PF07103.11 EFX03778.1 - 0.0027 17.4 0.0 0.0074 16.0 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1365) DUF3572 PF12096.8 EFX03778.1 - 0.023 14.9 0.0 0.067 13.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) FPN1 PF06963.12 EFX03779.1 - 1.7e-109 366.3 21.2 2.2e-109 365.9 21.2 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Abhydrolase_6 PF12697.7 EFX03779.1 - 1.1e-13 52.3 7.7 1.1e-13 52.3 7.7 2.4 3 0 0 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX03779.1 - 4.6e-11 42.4 0.1 8.7e-11 41.5 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFX03779.1 - 2.6e-07 30.7 0.4 4.7e-07 29.9 0.4 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EFX03779.1 - 2.9e-07 30.4 0.2 5.6e-07 29.5 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX03779.1 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Thioesterase PF00975.20 EFX03779.1 - 0.21 11.7 1.4 0.23 11.5 0.2 1.6 2 0 0 2 2 2 0 Thioesterase domain GRIM-19 PF06212.12 EFX03780.1 - 2.1e-22 79.5 0.0 4.7e-22 78.4 0.0 1.5 1 1 0 1 1 1 1 GRIM-19 protein CSD PF00313.22 EFX03781.1 - 2.3e-17 62.6 0.3 2.5e-17 62.5 0.3 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain DUF3638 PF12340.8 EFX03783.1 - 1.5e-84 282.9 0.1 3.4e-84 281.7 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EFX03783.1 - 1.4e-17 62.7 0.1 3.8e-17 61.4 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) RXT2_N PF08595.11 EFX03784.1 - 0.0046 17.0 1.8 0.075 13.1 0.3 2.3 2 0 0 2 2 2 1 RXT2-like, N-terminal PBP1_TM PF14812.6 EFX03784.1 - 0.033 14.5 3.1 0.033 14.5 3.1 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Afi1 PF07792.12 EFX03784.1 - 0.08 13.4 1.7 12 6.3 0.1 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Importin_rep_4 PF18808.1 EFX03784.1 - 0.15 12.4 1.6 0.38 11.1 1.6 1.6 1 0 0 1 1 1 0 Importin repeat CENP-B_dimeris PF09026.10 EFX03784.1 - 1.2 9.6 9.5 2.9 8.3 9.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain LZ_Tnp_IS66 PF13007.7 EFX03784.1 - 1.3 9.8 3.8 1 10.2 0.4 2.4 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain FAM176 PF14851.6 EFX03784.1 - 1.7 8.3 6.6 1.8 8.2 1.2 2.3 2 0 0 2 2 2 0 FAM176 family Cwf_Cwc_15 PF04889.12 EFX03784.1 - 2.6 7.7 15.8 0.082 12.6 2.2 2.6 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 EFX03784.1 - 2.7 7.0 16.1 0.37 9.9 4.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Apt1 PF10351.9 EFX03784.1 - 4.5 6.0 9.0 0.68 8.7 0.7 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain SR-25 PF10500.9 EFX03784.1 - 4.5 6.8 19.6 0.076 12.6 12.5 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Nup96 PF12110.8 EFX03785.1 - 1.5e-84 283.6 0.0 2.2e-84 283.1 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EFX03785.1 - 2.6e-45 154.2 0.0 4.5e-45 153.4 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EFX03785.1 - 1.3e-17 64.4 250.5 1.7e-05 25.6 32.3 10.0 4 1 6 10 10 10 7 Nucleoporin FG repeat region Nexin_C PF08628.12 EFX03785.1 - 0.13 12.9 0.4 3.5 8.3 0.0 2.8 2 1 0 2 2 2 0 Sorting nexin C terminal TMEM37 PF15108.6 EFX03787.1 - 0.046 13.6 0.4 0.079 12.8 0.4 1.3 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family EIIC-GAT PF03611.14 EFX03787.1 - 0.064 12.4 0.7 0.088 11.9 0.7 1.1 1 0 0 1 1 1 0 PTS system sugar-specific permease component GST_N_2 PF13409.6 EFX03788.1 - 4.7e-21 74.9 0.1 1.4e-20 73.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFX03788.1 - 7.6e-14 51.5 0.0 1.4e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFX03788.1 - 1.2e-05 25.7 0.0 0.00044 20.6 0.0 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFX03788.1 - 7.5e-05 22.9 0.0 0.00026 21.1 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EFX03788.1 - 0.0021 18.6 0.0 0.0039 17.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFX03788.1 - 0.0029 17.8 0.1 0.0084 16.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain SNF2_N PF00176.23 EFX03790.1 - 3.4e-75 252.9 0.1 6.8e-75 252.0 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EFX03790.1 - 3.2e-43 146.4 2.7 8.5e-43 145.0 2.7 1.8 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 EFX03790.1 - 3.2e-30 105.1 2.2 3.2e-30 105.1 2.2 3.4 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 EFX03790.1 - 3.7e-18 65.9 0.0 1.5e-17 63.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX03790.1 - 5.4e-11 42.8 0.0 2.5e-10 40.6 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFX03790.1 - 0.00024 20.4 0.0 0.00074 18.8 0.0 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EFX03790.1 - 0.00026 20.8 0.0 0.00064 19.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Occludin_ELL PF07303.13 EFX03790.1 - 0.01 16.6 5.3 0.039 14.7 5.3 2.0 1 0 0 1 1 1 0 Occludin homology domain DEAD_2 PF06733.15 EFX03790.1 - 0.032 13.8 0.0 0.077 12.6 0.0 1.6 1 0 0 1 1 1 0 DEAD_2 Myb_DNA-binding PF00249.31 EFX03790.1 - 0.046 13.9 0.1 9.1 6.6 0.0 3.1 3 0 0 3 3 3 0 Myb-like DNA-binding domain DUF3847 PF12958.7 EFX03790.1 - 0.084 13.0 1.2 0.3 11.2 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) GFA PF04828.14 EFX03791.1 - 0.015 15.6 0.3 0.031 14.6 0.0 1.7 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme OGFr_III PF04680.13 EFX03791.1 - 0.23 12.1 0.6 0.23 12.1 0.6 2.6 3 0 0 3 3 3 0 Opioid growth factor receptor repeat MFS_1 PF07690.16 EFX03793.1 - 6.2e-43 147.1 65.0 3.7e-40 137.9 64.6 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX03793.1 - 3.5e-15 55.5 19.0 3.5e-15 55.5 19.0 1.6 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFX03793.1 - 1.2e-14 54.0 14.3 1.2e-14 54.0 14.3 3.6 2 1 1 3 3 3 1 Sugar (and other) transporter RED_N PF07808.13 EFX03794.1 - 3.3e-07 30.2 9.2 3.3e-07 30.2 9.2 3.0 3 0 0 3 3 3 1 RED-like protein N-terminal region Herpes_UL14 PF03580.14 EFX03794.1 - 0.00092 19.5 0.3 0.005 17.1 0.3 2.4 1 0 0 1 1 1 1 Herpesvirus UL14-like protein Miga PF10265.9 EFX03794.1 - 0.051 12.6 7.6 0.11 11.4 7.6 1.5 1 0 0 1 1 1 0 Mitoguardin RTA1 PF04479.13 EFX03796.1 - 1.4e-22 80.3 4.2 1.5e-18 67.1 0.6 2.2 1 1 1 2 2 2 2 RTA1 like protein zf-C2H2 PF00096.26 EFX03797.1 - 7.5e-11 41.9 18.3 2.6e-06 27.6 2.1 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFX03797.1 - 2.7e-07 30.7 13.3 7.7e-06 26.1 6.6 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EFX03797.1 - 1.1e-05 25.6 4.5 0.0036 17.5 0.6 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX03797.1 - 1.9e-05 24.9 5.4 0.00063 20.0 0.2 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EFX03797.1 - 7.9e-05 23.2 20.8 0.0048 17.6 1.1 3.5 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFX03797.1 - 0.0012 18.8 9.4 0.15 12.1 2.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-LYAR PF08790.11 EFX03797.1 - 0.43 10.5 3.0 1.3 9.0 0.3 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger DUF4636 PF15468.6 EFX03797.1 - 0.49 10.1 7.9 0.79 9.4 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) zf_C2H2_ZHX PF18387.1 EFX03797.1 - 3 7.5 9.6 1.3 8.7 0.7 3.0 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 EFX03797.1 - 3.6 7.7 5.6 1.5 8.9 2.6 2.0 1 1 1 2 2 2 0 BED zinc finger zf-C2HE PF16278.5 EFX03797.1 - 6 7.4 6.5 80 3.8 6.7 2.8 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4743 PF15916.5 EFX03798.1 - 1.7e-10 40.9 0.0 2.9e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 EFX03798.1 - 1.1e-09 38.5 0.0 2.2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DAHP_synth_2 PF01474.16 EFX03799.1 - 1.1e-199 663.5 0.0 1.2e-199 663.3 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Rep_fac-A_C PF08646.10 EFX03800.1 - 2.4e-55 186.3 0.2 7.3e-54 181.5 0.2 2.2 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EFX03800.1 - 3.7e-36 123.0 0.2 2.3e-35 120.4 0.2 2.2 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 EFX03800.1 - 4.8e-20 71.5 0.0 9.7e-20 70.5 0.0 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EFX03800.1 - 7.5e-16 57.9 0.6 6.6e-11 42.0 0.0 4.1 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EFX03800.1 - 0.00018 21.3 0.1 0.026 14.2 0.1 2.4 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 DUF5521 PF17659.1 EFX03800.1 - 0.044 11.7 0.0 0.12 10.2 0.0 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5521) FAD_binding_4 PF01565.23 EFX03801.1 - 1.7e-21 76.4 2.1 4.7e-21 75.0 2.1 1.9 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX03801.1 - 0.00019 21.5 0.0 0.00038 20.5 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like OMPdecase PF00215.24 EFX03802.1 - 2.2e-90 302.2 0.0 2.7e-90 301.9 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family NAD_binding_3 PF03447.16 EFX03802.1 - 0.12 13.0 0.3 2.1 9.0 0.2 2.7 3 0 0 3 3 3 0 Homoserine dehydrogenase, NAD binding domain F-box-like PF12937.7 EFX03804.1 - 0.0046 16.8 0.1 0.011 15.6 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFX03804.1 - 0.087 12.7 0.2 2.7 7.9 0.0 2.3 2 0 0 2 2 2 0 F-box F-box PF00646.33 EFX03804.1 - 0.13 12.2 0.1 0.36 10.8 0.1 1.8 1 0 0 1 1 1 0 F-box domain Glyco_tranf_2_3 PF13641.6 EFX03805.1 - 3.9e-26 92.4 0.0 8.1e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EFX03805.1 - 4.9e-12 46.2 3.1 4.9e-12 46.2 3.1 2.4 2 0 0 2 2 2 2 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EFX03805.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EFX03805.1 - 0.018 14.5 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 21 AltA1 PF16541.5 EFX03806.1 - 0.0072 17.2 0.1 0.0093 16.8 0.1 1.3 1 0 0 1 1 1 1 Alternaria alternata allergen 1 Tom5 PF10642.9 EFX03807.1 - 0.027 14.5 0.0 0.086 12.9 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Ribosomal_60s PF00428.19 EFX03807.1 - 0.78 10.4 7.1 0.32 11.6 4.1 1.9 1 1 1 2 2 2 0 60s Acidic ribosomal protein Pkinase PF00069.25 EFX03808.1 - 8.6e-47 159.7 0.0 1e-45 156.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03808.1 - 9.4e-23 80.8 0.0 1.4e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFX03808.1 - 0.003 17.5 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFX03808.1 - 0.022 13.7 0.0 0.041 12.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain SAPS PF04499.15 EFX03808.1 - 2.2 6.9 5.4 3.8 6.2 5.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 EFX03808.1 - 4.6 7.0 9.3 10 5.8 9.3 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RWD PF05773.22 EFX03809.1 - 4.5e-21 75.3 0.1 7.1e-21 74.7 0.1 1.3 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EFX03809.1 - 4.7e-05 23.8 5.1 6.5e-05 23.3 3.9 1.9 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 Phage_B PF02304.15 EFX03809.1 - 0.096 13.1 0.1 0.16 12.3 0.1 1.3 1 0 0 1 1 1 0 Scaffold protein B Herpes_UL46 PF03387.14 EFX03811.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL46 protein zf-C3HC4_2 PF13923.6 EFX03812.1 - 3e-12 46.2 13.5 3.1e-12 46.1 9.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 EFX03812.1 - 1.7e-08 34.0 2.3 2.1e-08 33.7 0.5 2.2 2 0 0 2 2 2 1 SAP domain zf-C3HC4 PF00097.25 EFX03812.1 - 4.6e-08 32.8 10.2 4.6e-08 32.8 10.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX03812.1 - 3.5e-07 30.1 7.9 3.5e-07 30.1 7.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFX03812.1 - 2.1e-06 27.5 7.9 2.1e-06 27.5 7.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFX03812.1 - 3.3e-06 27.3 15.4 1.4e-05 25.3 9.9 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EFX03812.1 - 4.9e-06 26.4 9.4 4.9e-06 26.4 9.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFX03812.1 - 6.5e-06 25.9 11.0 0.00021 21.1 8.3 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EFX03812.1 - 2.1e-05 24.3 2.6 2.1e-05 24.3 2.6 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EFX03812.1 - 3e-05 24.1 9.8 3e-05 24.1 9.8 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EFX03812.1 - 0.00026 21.2 6.6 0.00026 21.2 6.6 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EFX03812.1 - 0.0008 19.5 5.7 0.0019 18.3 5.7 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 Mob_synth_C PF06463.13 EFX03812.1 - 0.0015 18.4 4.1 0.0036 17.2 4.1 1.6 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C U-box PF04564.15 EFX03812.1 - 0.0081 16.3 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_4 PF14570.6 EFX03812.1 - 0.014 15.2 2.1 0.014 15.2 2.1 2.8 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EFX03812.1 - 0.076 13.1 2.8 0.2 11.7 2.8 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger LEM PF03020.15 EFX03812.1 - 0.1 12.2 0.7 0.23 11.0 0.7 1.6 1 0 0 1 1 1 0 LEM domain zf-P11 PF03854.14 EFX03812.1 - 0.95 9.2 12.3 0.36 10.5 6.7 2.3 2 0 0 2 2 2 0 P-11 zinc finger Ribosomal_L44 PF00935.19 EFX03813.1 - 3.4e-35 120.4 12.9 5.4e-35 119.7 12.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 HET PF06985.11 EFX03814.1 - 4.9e-14 52.9 0.3 0.00069 20.0 0.0 3.4 1 1 2 3 3 3 3 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.23 EFX03815.1 - 1.4e-66 224.6 0.6 4.7e-64 216.3 0.6 3.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX03815.1 - 5.5e-12 46.0 0.0 1.3e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX03815.1 - 4e-06 26.9 0.0 8.4e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFX03815.1 - 1.5e-05 24.8 0.0 3.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 EFX03815.1 - 0.017 14.7 0.0 0.044 13.4 0.0 1.6 2 0 0 2 2 2 0 DEAD_2 PGA2 PF07543.12 EFX03815.1 - 7.2 6.6 9.5 0.78 9.7 0.9 2.5 2 0 0 2 2 2 0 Protein trafficking PGA2 Anp1 PF03452.14 EFX03817.1 - 4.9e-113 376.9 0.0 8.4e-113 376.1 0.0 1.4 1 0 0 1 1 1 1 Anp1 MFS_1 PF07690.16 EFX03818.1 - 1.1e-46 159.4 40.8 1.1e-46 159.4 40.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03818.1 - 3.8e-12 45.8 9.4 3.8e-12 45.8 9.4 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter ATP-synt_F PF01990.17 EFX03819.1 - 1.3e-33 115.2 0.1 1.5e-33 115.0 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit SWIRM-assoc_3 PF16498.5 EFX03819.1 - 0.025 14.8 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the C-terminal RNA_pol_Rpb8 PF03870.15 EFX03820.1 - 6.6e-45 152.7 0.0 7.5e-45 152.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EFX03820.1 - 6.3e-06 26.2 0.1 0.011 15.8 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G Auxin_repressed PF05564.12 EFX03820.1 - 0.17 12.6 0.0 0.21 12.3 0.0 1.2 1 0 0 1 1 1 0 Dormancy/auxin associated protein APH PF01636.23 EFX03821.1 - 5.7e-17 62.4 0.0 4.3e-16 59.6 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFX03821.1 - 4e-05 22.7 0.0 5.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EFX03821.1 - 6.9e-05 22.3 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EFX03821.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.25 EFX03821.1 - 0.23 10.8 0.0 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain Methyltransf_25 PF13649.6 EFX03822.1 - 4.4e-15 56.2 0.0 9.2e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03822.1 - 2.3e-13 50.2 0.0 3e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03822.1 - 1.4e-11 44.9 0.0 5.2e-11 43.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03822.1 - 1.5e-08 35.2 0.0 2.5e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFX03822.1 - 3.2e-06 27.0 0.0 5.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EFX03822.1 - 8.9e-06 25.6 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX03822.1 - 8.2e-05 22.2 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFX03822.1 - 0.0011 18.5 0.1 0.0015 18.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EFX03822.1 - 0.0035 17.3 0.0 0.0049 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX03822.1 - 0.0036 16.7 0.0 0.0048 16.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 EFX03822.1 - 0.015 14.4 0.0 0.021 13.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NMT PF01233.19 EFX03822.1 - 0.045 13.6 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Methyltransf_9 PF08003.11 EFX03822.1 - 0.055 12.4 0.0 0.069 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.20 EFX03822.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF1749 PF08538.10 EFX03823.1 - 1.9e-83 280.0 0.0 2.3e-83 279.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EFX03823.1 - 9.7e-07 29.6 0.0 1.2e-06 29.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX03823.1 - 0.00047 19.5 0.0 0.0017 17.6 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFX03823.1 - 0.011 15.4 0.0 0.03 14.0 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF4744 PF15918.5 EFX03824.1 - 6.8 7.6 7.6 18 6.2 7.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) Cys_Met_Meta_PP PF01053.20 EFX03825.1 - 1.9e-137 457.9 0.0 2.2e-137 457.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFX03825.1 - 1.3e-05 24.5 0.0 2.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFX03825.1 - 9.7e-05 21.5 0.0 0.00018 20.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V GDC-P PF02347.16 EFX03825.1 - 0.00097 18.1 0.0 0.0015 17.4 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein DegT_DnrJ_EryC1 PF01041.17 EFX03825.1 - 0.0045 16.3 0.0 0.014 14.7 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EFX03825.1 - 0.06 12.6 0.4 0.42 9.8 0.4 2.1 1 1 0 1 1 1 0 Beta-eliminating lyase POTRA_2 PF08479.11 EFX03825.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, ShlB-type E1_DerP2_DerF2 PF02221.15 EFX03826.1 - 1.4e-27 96.8 0.2 1.6e-27 96.6 0.2 1.1 1 0 0 1 1 1 1 ML domain DUF4748 PF15932.5 EFX03827.1 - 4.5e-24 84.0 0.7 6e-24 83.5 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) MFS_2 PF13347.6 EFX03828.1 - 1.8e-05 23.5 2.9 3.1e-05 22.7 1.1 2.2 2 1 0 2 2 2 1 MFS/sugar transport protein PUCC PF03209.15 EFX03828.1 - 0.023 13.7 0.6 0.023 13.7 0.6 1.8 2 0 0 2 2 2 0 PUCC protein DUF2116 PF09889.9 EFX03828.1 - 0.039 14.0 0.1 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) adh_short PF00106.25 EFX03829.1 - 0.00064 19.2 0.8 0.005 16.3 1.1 2.3 2 1 0 2 2 2 1 short chain dehydrogenase RNase_HII PF01351.18 EFX03830.1 - 3.1e-32 112.0 0.0 4.4e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII DUF3678 PF12435.8 EFX03830.1 - 0.033 13.6 0.6 1.8 8.0 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Ion_trans PF00520.31 EFX03831.1 - 2.4e-06 26.9 7.4 3.1e-06 26.6 7.4 1.1 1 0 0 1 1 1 1 Ion transport protein DivIC PF04977.15 EFX03831.1 - 0.0048 16.6 0.5 0.01 15.6 0.5 1.6 1 0 0 1 1 1 1 Septum formation initiator DUF485 PF04341.12 EFX03831.1 - 0.024 14.6 3.4 0.044 13.7 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF948 PF06103.11 EFX03831.1 - 0.051 13.8 0.1 0.051 13.8 0.1 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.11 EFX03831.1 - 0.06 13.6 1.5 0.094 13.0 1.5 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 HALZ PF02183.18 EFX03831.1 - 0.061 13.6 1.5 0.11 12.7 1.5 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper WD40 PF00400.32 EFX03833.1 - 8.8e-36 121.3 22.9 3.7e-08 33.9 0.1 12.1 13 0 0 13 13 13 6 WD domain, G-beta repeat Utp12 PF04003.12 EFX03833.1 - 7.6e-25 87.3 0.0 1.2e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EFX03833.1 - 1.6e-18 66.8 0.0 0.013 15.8 0.0 9.7 5 2 6 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX03833.1 - 6.4e-08 31.9 1.6 3.7 6.4 0.0 6.5 5 2 2 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFX03833.1 - 2.6e-06 27.4 1.7 0.054 13.4 0.2 4.7 4 1 1 5 5 5 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EFX03833.1 - 0.0025 16.5 4.3 7 5.2 0.1 4.4 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFX03833.1 - 0.011 14.5 0.0 0.39 9.4 0.0 3.0 2 1 0 2 2 2 0 Nup133 N terminal like PD40 PF07676.12 EFX03833.1 - 0.11 12.5 1.4 80 3.4 0.0 4.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EFX03833.1 - 0.15 11.3 0.0 5 6.4 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain PALB2_WD40 PF16756.5 EFX03833.1 - 0.16 10.9 0.0 4.2 6.2 0.0 2.7 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PQQ_3 PF13570.6 EFX03833.1 - 0.26 11.8 1.2 29 5.3 0.0 4.3 5 0 0 5 5 4 0 PQQ-like domain Pkinase PF00069.25 EFX03834.1 - 2.8e-10 40.0 0.0 4.7e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03834.1 - 9.2e-09 35.0 0.0 1.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 EFX03834.1 - 2.1e-08 33.7 0.2 0.09 13.1 0.0 5.0 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EFX03834.1 - 2e-06 27.9 0.1 3.9e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFX03834.1 - 0.001 19.5 0.0 2.3 8.8 0.1 3.2 2 0 0 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.6 EFX03834.1 - 0.0014 19.0 0.1 0.056 13.8 0.0 3.8 3 1 1 5 5 5 2 HEAT repeats Kinase-like PF14531.6 EFX03834.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Cohesin_HEAT PF12765.7 EFX03834.1 - 0.28 11.5 1.0 1.1 9.6 0.1 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion DUF4097 PF13349.6 EFX03835.1 - 0.03 13.7 0.0 9.8 5.4 0.0 3.2 2 1 1 3 3 3 0 Putative adhesin ADH_N PF08240.12 EFX03836.1 - 5.8e-26 90.5 4.4 1.1e-25 89.6 4.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX03836.1 - 5.3e-20 71.7 0.0 1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX03836.1 - 3.7e-06 28.0 0.0 6.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX03836.1 - 9.1e-06 25.1 1.1 2e-05 24.0 0.1 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EFX03836.1 - 0.0007 19.0 0.1 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EFX03836.1 - 0.025 15.4 0.0 0.064 14.1 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Shikimate_DH PF01488.20 EFX03836.1 - 0.041 13.9 0.0 0.081 13.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glycos_transf_4 PF00953.21 EFX03837.1 - 3.7e-25 88.7 12.2 3.7e-25 88.7 12.2 2.1 1 1 1 2 2 2 1 Glycosyl transferase family 4 Asp PF00026.23 EFX03838.1 - 4.4e-67 226.7 9.8 5.4e-67 226.5 9.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX03838.1 - 7.8e-11 42.5 3.9 3.1e-06 27.5 0.1 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal ORMDL PF04061.14 EFX03839.1 - 1.5e-58 196.4 3.0 1.8e-58 196.2 3.0 1.1 1 0 0 1 1 1 1 ORMDL family TMEM220 PF15071.6 EFX03839.1 - 0.11 13.2 0.8 3.4 8.5 0.1 2.1 2 0 0 2 2 2 0 Transmembrane family 220, helix PP28 PF10252.9 EFX03840.1 - 2e-28 98.7 14.4 2e-28 98.7 14.4 3.1 3 0 0 3 3 3 1 Casein kinase substrate phosphoprotein PP28 DUF4718 PF15842.5 EFX03840.1 - 3.2 7.5 8.9 0.27 11.0 1.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4718) Clat_adaptor_s PF01217.20 EFX03841.1 - 3.1e-51 173.1 0.9 4.2e-51 172.6 0.9 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 EFX03841.1 - 0.038 14.7 0.1 0.073 13.8 0.1 1.5 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Methyltransf_23 PF13489.6 EFX03842.1 - 1.6e-11 44.3 0.0 2.3e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03842.1 - 1.8e-11 44.6 0.0 4e-11 43.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03842.1 - 6.2e-11 42.8 0.0 1.3e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03842.1 - 3.1e-08 33.6 0.0 2.7e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03842.1 - 2.2e-07 31.5 0.0 2e-06 28.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX03842.1 - 8.1e-05 22.1 0.0 0.001 18.5 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EFX03842.1 - 0.00056 20.1 0.0 0.0013 18.9 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EFX03842.1 - 0.0088 15.5 0.0 0.032 13.7 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EFX03842.1 - 0.038 13.5 0.0 0.09 12.3 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_8 PF05148.15 EFX03842.1 - 0.057 13.3 0.0 0.56 10.0 0.0 2.1 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_16 PF10294.9 EFX03842.1 - 0.097 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Period_C PF12114.8 EFX03842.1 - 0.1 12.2 0.7 0.18 11.4 0.7 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Methyltransf_2 PF00891.18 EFX03842.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_PK PF05891.12 EFX03842.1 - 0.14 11.7 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase CAP_GLY PF01302.25 EFX03843.1 - 7.1e-17 61.2 0.6 1.8e-16 59.9 0.6 1.8 1 1 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EFX03843.1 - 2e-10 40.7 3.6 0.022 15.2 0.1 4.7 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFX03843.1 - 1.6e-06 27.7 6.7 0.073 12.8 0.5 4.5 2 2 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 EFX03843.1 - 2.2e-06 27.3 0.0 0.026 14.0 0.0 3.2 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EFX03843.1 - 0.022 14.8 1.2 35 4.8 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich repeat Sec7 PF01369.20 EFX03844.1 - 1.5e-63 213.8 0.0 4.1e-63 212.4 0.0 1.8 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EFX03844.1 - 1.4e-16 60.7 0.1 4e-15 56.1 0.0 3.1 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EFX03844.1 - 0.0021 17.7 1.7 0.0037 17.0 0.2 2.2 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Ric8 PF10165.9 EFX03844.1 - 0.026 13.6 0.0 0.047 12.7 0.0 1.3 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn DUF4666 PF15697.5 EFX03844.1 - 0.062 14.0 0.1 0.22 12.2 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) Peptidase_C15 PF01470.17 EFX03845.1 - 8.5e-09 35.9 0.0 0.0038 17.4 0.0 3.3 4 0 0 4 4 4 3 Pyroglutamyl peptidase ADH_N PF08240.12 EFX03846.1 - 1.9e-27 95.3 0.1 3.8e-27 94.3 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX03846.1 - 3.5e-09 36.7 0.1 7.6e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EFX03846.1 - 4e-07 29.9 0.6 1e-06 28.6 0.6 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Glu_dehyd_C PF16912.5 EFX03846.1 - 1.5e-05 24.6 0.1 6.8e-05 22.4 0.0 2.0 3 0 0 3 3 3 1 Glucose dehydrogenase C-terminus HI0933_like PF03486.14 EFX03846.1 - 0.0019 16.9 0.4 0.012 14.4 0.1 1.9 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EFX03846.1 - 0.009 15.3 0.2 0.015 14.6 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EFX03846.1 - 0.049 12.9 0.4 0.28 10.4 0.4 2.0 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX03846.1 - 0.079 12.5 0.3 0.14 11.7 0.3 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX03846.1 - 0.085 11.9 0.5 0.11 11.5 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EFX03846.1 - 0.1 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 EFX03846.1 - 0.14 12.7 0.1 0.35 11.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFX03846.1 - 0.21 10.8 0.1 0.35 10.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Kelch_4 PF13418.6 EFX03849.1 - 4.9e-23 80.9 16.3 5.9e-09 35.8 0.2 7.1 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFX03849.1 - 2.2e-22 78.5 5.8 8.7e-07 29.0 0.0 5.9 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFX03849.1 - 5.4e-22 77.1 4.7 5.5e-08 32.3 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFX03849.1 - 2.1e-21 75.7 17.6 4.6e-06 26.8 0.2 8.3 8 1 0 8 8 8 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EFX03849.1 - 4.1e-15 55.4 5.9 0.0016 18.3 0.0 7.2 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.15 EFX03849.1 - 3.4e-14 52.1 8.2 1.8e-05 24.5 0.3 5.7 5 1 0 5 5 5 3 Kelch motif Lipase_GDSL_2 PF13472.6 EFX03849.1 - 0.042 14.2 0.3 0.11 12.8 0.3 1.7 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family eIF-5_eIF-2B PF01873.17 EFX03850.1 - 4e-39 133.1 0.0 8.2e-39 132.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EFX03850.1 - 1.1e-22 79.9 0.4 1.1e-22 79.9 0.4 2.6 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Cys_rich_KTR PF14205.6 EFX03850.1 - 0.29 11.0 1.9 2.9 7.8 0.4 2.4 1 1 1 2 2 2 0 Cysteine-rich KTR SpoIIE PF07228.12 EFX03851.1 - 7e-10 39.1 0.2 2.6e-09 37.3 0.1 1.8 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EFX03851.1 - 8.3e-09 35.5 0.3 0.0062 16.2 0.0 3.1 3 0 0 3 3 3 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFX03851.1 - 1.3e-07 31.5 0.3 2.8e-07 30.4 0.3 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C Acetate_kinase PF00871.17 EFX03853.1 - 4e-85 285.9 0.0 5.3e-85 285.5 0.0 1.1 1 0 0 1 1 1 1 Acetokinase family Apt1 PF10351.9 EFX03853.1 - 0.4 9.5 3.3 0.51 9.1 3.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MoaC PF01967.21 EFX03854.1 - 2.7e-51 173.2 1.6 4.2e-51 172.6 1.6 1.3 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EFX03854.1 - 5.5e-33 113.6 0.0 1.9e-32 111.9 0.0 1.9 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EFX03854.1 - 1.3e-25 90.7 0.0 5.5e-25 88.7 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EFX03854.1 - 0.00014 22.1 0.0 0.00048 20.4 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain UPRTase PF14681.6 EFX03856.1 - 5.1e-48 163.3 0.0 2e-45 154.8 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFX03856.1 - 1.1e-07 31.6 0.0 1.4e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MFS_1 PF07690.16 EFX03857.1 - 1.6e-46 158.9 15.9 1.6e-46 158.9 15.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03857.1 - 3.8e-08 32.6 6.4 3.8e-08 32.6 6.4 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter NACHT PF05729.12 EFX03859.1 - 2.2e-15 57.0 0.0 5.8e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFX03859.1 - 1.1e-08 35.4 0.0 1.3e-07 32.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFX03859.1 - 4.2e-08 32.7 0.0 9.7e-08 31.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain NLRC4_HD2 PF17776.1 EFX03859.1 - 0.00013 22.6 0.5 0.0012 19.4 0.0 3.0 3 1 0 3 3 3 1 NLRC4 helical domain HD2 AAA_16 PF13191.6 EFX03859.1 - 0.00056 20.3 3.3 0.0067 16.8 2.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain NTPase_1 PF03266.15 EFX03859.1 - 0.07 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NTPase PduV-EutP PF10662.9 EFX03859.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 EFX03859.1 - 0.092 13.1 0.0 2.4 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EFX03859.1 - 0.1 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 EFX03859.1 - 0.1 12.6 0.0 0.54 10.3 0.0 2.4 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFX03859.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFX03859.1 - 0.1 13.1 0.1 0.31 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EFX03859.1 - 0.12 12.9 0.0 0.45 10.9 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EFX03859.1 - 0.13 12.4 0.1 14 5.7 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain Hist_deacetyl PF00850.19 EFX03860.1 - 6.1e-80 269.0 0.1 1.8e-79 267.4 0.0 1.8 2 0 0 2 2 2 1 Histone deacetylase domain SH3_9 PF14604.6 EFX03861.1 - 4.9e-05 23.1 0.2 0.0001 22.1 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFX03861.1 - 0.00032 20.2 0.5 0.00061 19.3 0.5 1.5 1 0 0 1 1 1 1 SH3 domain Yip1 PF04893.17 EFX03861.1 - 0.02 14.6 0.9 0.034 13.9 0.9 1.3 1 0 0 1 1 1 0 Yip1 domain VPDSG-CTERM PF18205.1 EFX03861.1 - 7.9 6.4 7.9 31 4.5 7.9 2.1 1 0 0 1 1 1 0 VPDSG-CTERM motif NACHT PF05729.12 EFX03862.1 - 1.4e-11 44.6 0.1 3.8e-11 43.2 0.1 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFX03862.1 - 2.3e-07 31.4 0.0 1e-06 29.3 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Ank_3 PF13606.6 EFX03862.1 - 6.7e-06 26.1 0.7 0.32 11.7 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFX03862.1 - 2.8e-05 24.3 0.4 0.0051 17.2 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EFX03862.1 - 3.2e-05 24.1 0.1 0.0053 17.1 0.1 3.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) AAA_18 PF13238.6 EFX03862.1 - 0.00017 22.2 0.0 0.0005 20.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain Ank_2 PF12796.7 EFX03862.1 - 0.00032 21.2 0.1 0.0018 18.8 0.0 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) AAA_22 PF13401.6 EFX03862.1 - 0.00036 20.8 0.0 0.0013 19.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain SesA PF17107.5 EFX03862.1 - 0.00043 20.5 0.1 0.0016 18.6 0.1 2.1 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Ank_4 PF13637.6 EFX03862.1 - 0.0027 18.2 0.1 0.07 13.7 0.1 3.2 3 1 1 4 4 4 1 Ankyrin repeats (many copies) TIP49 PF06068.13 EFX03862.1 - 0.0067 15.7 1.0 0.067 12.4 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 EFX03862.1 - 0.033 14.3 0.6 0.1 12.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFX03862.1 - 0.048 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.23 EFX03862.1 - 0.12 12.5 0.1 0.72 10.0 0.0 2.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA PF00004.29 EFX03862.1 - 0.13 12.7 4.0 0.18 12.2 0.6 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EFX03862.1 - 0.13 11.9 1.5 2.5 7.7 0.1 2.6 2 1 0 3 3 3 0 AAA domain APS_kinase PF01583.20 EFX03862.1 - 0.16 11.9 0.1 0.47 10.3 0.1 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_17 PF13207.6 EFX03862.1 - 0.26 11.7 1.3 0.7 10.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain APH PF01636.23 EFX03863.1 - 1.9e-10 41.1 0.0 2.1e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFX03863.1 - 0.038 12.9 0.0 0.06 12.2 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) DUF4164 PF13747.6 EFX03863.1 - 0.05 13.9 0.1 0.098 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Choline_kinase PF01633.20 EFX03863.1 - 0.067 12.8 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EFX03863.1 - 0.17 11.5 0.1 0.23 11.0 0.1 1.4 1 1 0 1 1 1 0 RIO1 family DNA_pol_phi PF04931.13 EFX03863.1 - 0.37 8.8 4.1 0.4 8.7 4.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi SET PF00856.28 EFX03864.1 - 0.009 16.4 0.0 0.023 15.1 0.0 1.7 2 0 0 2 2 2 1 SET domain Mad3_BUB1_II PF08171.11 EFX03864.1 - 0.1 12.8 0.1 19 5.5 0.1 2.2 2 0 0 2 2 2 0 Mad3/BUB1 homology region 2 Oxidored_FMN PF00724.20 EFX03865.1 - 6.1e-66 223.0 0.0 7.3e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family JAB PF01398.21 EFX03866.1 - 1.8e-32 111.8 0.0 3.5e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFX03866.1 - 7.6e-12 45.6 0.6 1.5e-11 44.7 0.6 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EFX03866.1 - 4.1e-07 29.8 0.0 7.8e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Pyr_redox_2 PF07992.14 EFX03867.1 - 2e-52 178.3 0.1 3e-52 177.7 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX03867.1 - 1.6e-11 44.6 0.0 5.5e-10 39.7 0.1 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EcoR124_C PF12008.8 EFX03867.1 - 0.0042 16.8 0.0 0.0064 16.2 0.0 1.2 1 0 0 1 1 1 1 Type I restriction and modification enzyme - subunit R C terminal Pyr_redox_3 PF13738.6 EFX03867.1 - 0.0053 16.0 0.0 0.95 8.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DUF4261 PF14080.6 EFX03867.1 - 0.2 11.8 0.0 0.47 10.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) TPPII_N PF12583.8 EFX03867.1 - 0.33 11.6 1.4 16 6.1 0.0 2.4 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal Pkinase PF00069.25 EFX03868.1 - 1.9e-31 109.4 0.0 4.2e-31 108.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03868.1 - 1.1e-15 57.6 0.0 1.9e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX03868.1 - 0.0019 17.6 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFX03868.1 - 0.038 13.9 0.1 0.31 10.9 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFX03868.1 - 0.087 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family F1F0-ATPsyn_F PF10791.9 EFX03869.1 - 3.3e-40 136.5 0.5 3.8e-40 136.3 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 EFX03869.1 - 0.052 13.9 0.1 0.065 13.6 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f PgaD PF13994.6 EFX03870.1 - 0.012 15.7 0.1 0.018 15.1 0.1 1.3 1 0 0 1 1 1 0 PgaD-like protein Mid2 PF04478.12 EFX03871.1 - 0.024 14.4 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Phage_holin_3_6 PF07332.11 EFX03871.1 - 0.028 14.4 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III K_channel_TID PF07941.11 EFX03872.1 - 0.0067 16.9 14.3 0.0067 16.9 14.3 4.6 3 1 1 4 4 4 1 Potassium channel Kv1.4 tandem inactivation domain MFS_1 PF07690.16 EFX03873.1 - 2.1e-25 89.4 49.3 4.7e-24 85.0 36.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 EFX03875.1 - 5.2e-65 219.4 0.0 6.6e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03875.1 - 6.6e-26 91.2 0.0 9.4e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EFX03875.1 - 0.038 14.7 0.7 0.14 12.8 0.1 2.4 2 0 0 2 2 2 0 Protein kinase C terminal domain Haspin_kinase PF12330.8 EFX03875.1 - 0.086 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EFX03875.1 - 0.11 12.1 0.1 2.2 7.9 0.0 2.3 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EFX03875.1 - 0.2 10.9 0.3 0.83 8.9 0.0 2.1 2 1 0 2 2 2 0 Kinase-like RSN1_7TM PF02714.15 EFX03876.1 - 2.3e-81 273.1 11.2 4.6e-81 272.1 11.2 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFX03876.1 - 1.6e-41 141.7 3.2 1.6e-41 141.7 3.2 2.2 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFX03876.1 - 1.1e-27 97.4 0.0 6.8e-27 94.8 0.0 2.1 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EFX03876.1 - 6.2e-23 80.8 0.1 6.2e-23 80.8 0.1 2.3 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter BRCT_2 PF16589.5 EFX03877.1 - 0.00061 20.1 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Oxysterol_BP PF01237.18 EFX03878.1 - 2.3e-49 168.2 0.0 1.1e-38 133.1 0.0 2.4 1 1 1 2 2 2 2 Oxysterol-binding protein Fungal_trans PF04082.18 EFX03879.1 - 2.4e-21 76.0 0.0 3.8e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03879.1 - 1.4e-06 28.3 8.2 3.2e-06 27.2 8.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FliT PF05400.13 EFX03879.1 - 0.16 12.8 0.8 0.59 11.0 0.8 2.0 1 0 0 1 1 1 0 Flagellar protein FliT DPBB_1 PF03330.18 EFX03880.1 - 6.2e-07 29.6 0.7 6.2e-07 29.6 0.7 2.2 3 0 0 3 3 3 1 Lytic transglycolase Redoxin PF08534.10 EFX03881.1 - 7.7e-26 90.6 0.0 9.3e-26 90.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EFX03881.1 - 8.5e-06 25.7 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family AhpC-TSA_2 PF13911.6 EFX03882.1 - 1.5e-16 60.5 0.0 2.2e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EFX03882.1 - 0.00013 21.9 0.0 0.00021 21.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFX03882.1 - 0.023 14.4 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Redoxin NUP PF06516.11 EFX03883.1 - 1.7e-135 451.3 0.1 2e-135 451.0 0.1 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) bZIP_1 PF00170.21 EFX03884.1 - 5e-07 29.7 8.1 8.1e-07 29.1 8.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFX03884.1 - 1e-06 28.7 7.8 1.6e-06 28.1 7.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EFX03884.1 - 0.00028 21.3 6.6 0.00044 20.7 6.6 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor HMMR_C PF15908.5 EFX03884.1 - 0.011 16.0 0.6 0.016 15.5 0.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal ZapB PF06005.12 EFX03884.1 - 0.016 15.7 0.7 0.024 15.1 0.7 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF724 PF05266.14 EFX03884.1 - 0.065 13.1 0.1 0.078 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 EFX03884.1 - 0.11 11.8 1.7 0.17 11.2 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cep57_CLD_2 PF14197.6 EFX03884.1 - 1.2 9.2 6.7 2.1 8.5 6.7 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF1003 PF06210.11 EFX03884.1 - 7.3 6.7 6.3 6 7.0 4.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) F-box PF00646.33 EFX03886.1 - 0.00065 19.5 0.2 0.0017 18.1 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFX03886.1 - 0.0026 17.6 0.5 0.0097 15.8 0.1 2.2 3 0 0 3 3 3 1 F-box-like PRANC PF09372.10 EFX03886.1 - 0.24 11.7 0.0 0.53 10.6 0.0 1.5 1 0 0 1 1 1 0 PRANC domain IPPT PF01715.17 EFX03887.1 - 4.2e-57 193.6 0.0 6.6e-57 193.0 0.0 1.2 1 0 0 1 1 1 1 IPP transferase zf-met PF12874.7 EFX03887.1 - 7.2e-05 23.0 0.1 0.00014 22.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFX03887.1 - 0.00023 21.4 0.1 0.00049 20.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding IPT PF01745.16 EFX03887.1 - 0.00038 19.9 0.0 0.00099 18.6 0.0 1.6 1 0 0 1 1 1 1 Isopentenyl transferase AAA_18 PF13238.6 EFX03887.1 - 0.0025 18.4 0.0 3.8 8.1 0.0 2.6 1 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EFX03887.1 - 0.0099 16.0 0.2 0.36 11.0 0.0 3.3 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 EFX03887.1 - 0.092 13.1 0.0 0.35 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain CTU2 PF10288.9 EFX03887.1 - 0.23 11.7 2.1 0.16 12.2 0.3 1.6 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Pkinase PF00069.25 EFX03888.1 - 5.5e-09 35.8 0.0 6.4e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX03888.1 - 0.00044 19.6 0.0 0.00053 19.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FmiP_Thoc5 PF09766.9 EFX03889.1 - 8.7e-32 110.8 15.9 1.2e-31 110.3 15.9 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 SPATA1_C PF15743.5 EFX03889.1 - 0.0047 17.0 9.1 0.023 14.8 5.0 2.3 2 0 0 2 2 2 1 Spermatogenesis-associated C-terminus ZapB PF06005.12 EFX03889.1 - 0.033 14.6 7.0 0.033 14.6 7.0 3.1 2 1 0 2 2 2 0 Cell division protein ZapB DUF641 PF04859.12 EFX03889.1 - 0.041 14.2 0.4 0.041 14.2 0.4 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF87 PF01935.17 EFX03889.1 - 0.08 13.0 3.3 0.1 12.6 3.3 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain YabA PF06156.13 EFX03889.1 - 0.19 12.3 10.1 2.3 8.9 0.8 2.4 2 0 0 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 EFX03889.1 - 0.35 10.2 8.8 0.48 9.7 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EFX03889.1 - 0.49 10.4 5.1 0.79 9.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3958 PF13125.6 EFX03889.1 - 1.1 9.5 15.6 1.4 9.2 9.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3958) Csm2_III-A PF03750.13 EFX03889.1 - 1.4 9.8 8.4 2.1 9.2 2.8 2.3 2 0 0 2 2 2 0 Csm2 Type III-A K-box PF01486.17 EFX03889.1 - 1.5 9.1 16.7 0.077 13.2 8.4 2.7 2 1 1 3 3 3 0 K-box region DUF4200 PF13863.6 EFX03889.1 - 1.6 9.2 17.1 7.4 7.0 3.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 EFX03889.1 - 5.8 7.4 26.4 7.2 7.1 14.7 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region His_Phos_1 PF00300.22 EFX03890.1 - 6.3e-13 48.8 0.1 1.5e-12 47.7 0.1 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Alba PF01918.21 EFX03891.1 - 0.00044 20.0 0.2 0.0015 18.3 0.0 2.0 3 0 0 3 3 3 1 Alba FSH1 PF03959.13 EFX03892.1 - 5.1e-33 114.5 0.0 2.2e-32 112.5 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) CK_II_beta PF01214.18 EFX03893.1 - 1.6e-72 243.2 0.0 3.1e-72 242.2 0.0 1.5 1 1 0 1 1 1 1 Casein kinase II regulatory subunit PBP1_TM PF14812.6 EFX03893.1 - 1.9 8.9 13.4 2.5 8.5 4.5 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PTPRCAP PF15713.5 EFX03893.1 - 4.2 7.7 17.5 11 6.3 9.0 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF4637 PF15470.6 EFX03893.1 - 5.7 6.6 15.8 0.057 13.2 4.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4637) RRN3 PF05327.11 EFX03893.1 - 6.3 5.2 8.3 0.16 10.5 0.9 1.8 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 ABC1 PF03109.16 EFX03895.1 - 1e-31 109.6 0.0 1.7e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family HA2 PF04408.23 EFX03896.1 - 2e-19 69.9 0.0 5e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFX03896.1 - 9.6e-14 51.7 0.0 2.3e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EFX03896.1 - 4.3e-08 33.4 0.0 8.8e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EFX03896.1 - 4.2e-07 29.9 0.1 2.5e-06 27.4 0.0 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFX03896.1 - 1.9e-05 25.0 0.0 4.4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFX03896.1 - 0.00026 20.2 0.0 0.00052 19.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EFX03896.1 - 0.02 14.6 0.1 0.63 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFX03896.1 - 0.083 12.6 0.1 0.37 10.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain Polysacc_synt_4 PF04669.13 EFX03896.1 - 0.84 9.2 2.3 5.5 6.5 0.1 3.0 4 0 0 4 4 4 0 Polysaccharide biosynthesis Peptidase_S8 PF00082.22 EFX03897.1 - 8.3e-13 48.3 0.1 1.4e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 Subtilase family LigB PF02900.18 EFX03898.1 - 2.3e-17 63.0 0.0 2.8e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase GST_N_2 PF13409.6 EFX03899.1 - 8.4e-18 64.4 0.0 1.8e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFX03899.1 - 2.2e-12 46.8 0.1 5.5e-12 45.5 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFX03899.1 - 0.0024 18.0 0.0 0.0046 17.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFX03899.1 - 0.0074 16.7 0.0 0.38 11.2 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFX03899.1 - 0.012 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Vps23_core PF09454.10 EFX03900.1 - 1.1e-19 70.1 0.0 2.3e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Vps23 core domain Mito_fiss_reg PF05308.11 EFX03900.1 - 0.048 13.7 1.3 0.06 13.4 1.3 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Stathmin PF00836.19 EFX03900.1 - 0.14 12.1 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Stathmin family V-SNARE_C PF12352.8 EFX03900.1 - 0.19 12.0 1.8 2.1 8.7 0.5 2.2 1 1 1 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus HAD PF12710.7 EFX03901.1 - 7.9e-06 26.4 0.1 0.26 11.7 0.1 2.8 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFX03901.1 - 0.0015 18.7 0.3 0.58 10.2 0.1 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EFX03901.1 - 0.0022 17.4 0.1 1 8.7 0.1 2.2 2 0 0 2 2 2 2 Putative Phosphatase Hydrolase_like PF13242.6 EFX03901.1 - 0.094 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Hydrolase PF00702.26 EFX03901.1 - 0.11 12.8 0.1 5.4 7.2 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Pro-kuma_activ PF09286.11 EFX03902.1 - 5.7e-38 130.4 0.0 2.6e-37 128.3 0.0 2.0 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Tti2 PF10521.9 EFX03905.1 - 2e-85 286.7 0.0 2.8e-85 286.3 0.0 1.2 1 0 0 1 1 1 1 Tti2 family HET PF06985.11 EFX03906.1 - 3.1e-12 47.1 0.0 4.8e-11 43.2 0.0 2.4 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Amidohydro_2 PF04909.14 EFX03907.1 - 1.4e-14 54.6 5.8 1.2e-13 51.5 4.5 2.2 2 1 0 2 2 2 1 Amidohydrolase Acyltransferase PF01553.21 EFX03907.1 - 0.16 11.6 0.0 0.39 10.3 0.0 1.6 1 0 0 1 1 1 0 Acyltransferase V-ATPase_G PF03179.15 EFX03908.1 - 3.3e-28 98.3 15.2 4.8e-28 97.8 15.2 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Borrelia_P83 PF05262.11 EFX03908.1 - 6.3 5.2 12.9 9 4.7 12.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SH2_2 PF14633.6 EFX03909.1 - 7.5e-86 287.0 0.0 1.6e-85 285.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 EFX03909.1 - 2.3e-37 128.0 0.2 5.4e-37 126.7 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EFX03909.1 - 6e-29 100.5 0.0 1.4e-28 99.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EFX03909.1 - 2e-27 95.8 0.0 7e-27 94.1 0.0 2.0 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 EFX03909.1 - 5.2e-20 71.8 26.2 5.2e-20 71.8 26.2 5.9 5 1 1 6 6 5 1 Acidic N-terminal SPT6 S1 PF00575.23 EFX03909.1 - 5.8e-07 29.8 0.7 1.3e-06 28.7 0.7 1.6 1 0 0 1 1 1 1 S1 RNA binding domain HHH_9 PF17674.1 EFX03909.1 - 3.5e-06 27.8 5.0 2.1e-05 25.3 2.1 3.6 2 1 0 2 2 2 1 HHH domain SH2 PF00017.24 EFX03909.1 - 0.00015 21.8 0.0 0.00043 20.3 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 EFX03909.1 - 0.016 15.4 0.0 0.053 13.8 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif Tex_YqgF PF16921.5 EFX03909.1 - 0.035 14.6 0.0 0.11 12.9 0.0 1.9 2 0 0 2 2 1 0 Tex protein YqgF-like domain DsrC PF04358.13 EFX03909.1 - 0.04 14.4 0.2 1.8 9.1 0.1 3.2 3 0 0 3 3 3 0 DsrC like protein DUF2716 PF10898.8 EFX03909.1 - 0.075 13.4 0.1 0.48 10.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2716) Glyco_hydro_43 PF04616.14 EFX03910.1 - 1.9e-20 73.4 9.6 1.7e-08 34.1 0.1 3.8 3 1 0 3 3 3 3 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 EFX03910.1 - 0.0022 17.6 0.0 0.064 12.8 0.0 2.7 3 0 0 3 3 3 1 Glycosyl hydrolases family 32 N-terminal domain 4HBT PF03061.22 EFX03911.1 - 8.4e-10 38.9 0.0 1.5e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EFX03911.1 - 2.8e-05 24.5 0.1 4e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily p450 PF00067.22 EFX03912.1 - 2.1e-56 191.6 0.0 3.6e-56 190.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Totivirus_coat PF05518.11 EFX03913.1 - 3.6 5.5 14.7 5.7 4.9 14.7 1.2 1 0 0 1 1 1 0 Totivirus coat protein ABC_tran PF00005.27 EFX03914.1 - 0.063 13.8 0.0 0.095 13.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter OPT PF03169.15 EFX03915.1 - 4.6e-124 415.3 39.9 6e-124 415.0 39.9 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein adh_short PF00106.25 EFX03916.1 - 1.7e-12 47.2 0.0 5.3e-10 39.1 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX03916.1 - 8.4e-07 28.8 0.0 0.00014 21.5 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX03916.1 - 0.0015 18.4 0.1 0.0024 17.8 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX03916.1 - 0.0044 16.5 0.0 0.0072 15.8 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ldh_1_N PF00056.23 EFX03916.1 - 0.17 12.0 0.2 0.77 9.8 0.2 2.0 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain MTS PF05175.14 EFX03919.1 - 0.0046 16.5 0.0 0.014 15.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain MCM PF00493.23 EFX03920.1 - 5.1e-51 172.9 2.5 3.7e-40 137.4 0.1 2.6 2 1 1 3 3 3 2 MCM P-loop domain MCM_OB PF17207.3 EFX03920.1 - 4e-30 104.3 0.1 6.9e-30 103.5 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFX03920.1 - 1.6e-24 86.1 1.9 3.9e-24 84.9 1.9 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFX03920.1 - 1.5e-10 41.6 0.0 4.9e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain BSP_II PF05432.11 EFX03920.1 - 0.0011 18.7 16.3 0.002 17.9 16.3 1.4 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DUF2457 PF10446.9 EFX03920.1 - 0.16 11.1 20.1 0.28 10.3 20.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MFS18 PF17352.2 EFX03920.1 - 0.61 10.5 3.3 2.5 8.5 3.3 2.0 1 1 1 2 2 2 0 Male Flower Specific protein 18 CDC45 PF02724.14 EFX03920.1 - 3.9 5.7 12.8 6.1 5.0 12.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EFX03920.1 - 6 4.8 18.8 12 3.9 18.8 1.4 1 0 0 1 1 1 0 DNA polymerase phi NPP1 PF05630.11 EFX03921.1 - 2.7e-06 27.6 4.6 1.1e-05 25.7 0.6 2.3 1 1 1 2 2 2 2 Necrosis inducing protein (NPP1) DUF2370 PF10176.9 EFX03922.1 - 1.3e-90 303.0 0.7 2e-90 302.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2370) TMEM51 PF15345.6 EFX03922.1 - 0.077 12.8 0.9 0.48 10.2 0.0 2.4 2 1 1 3 3 3 0 Transmembrane protein 51 DUF2561 PF10812.8 EFX03922.1 - 0.087 12.9 0.0 0.087 12.9 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2561) DUF202 PF02656.15 EFX03922.1 - 2.5 8.6 5.2 40 4.7 5.2 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Aminotran_1_2 PF00155.21 EFX03923.1 - 3.6e-35 121.8 0.0 4.6e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFX03923.1 - 0.00031 19.4 0.0 0.00059 18.5 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme TauD PF02668.16 EFX03924.1 - 0.00021 21.2 0.0 0.00024 21.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 7tm_2 PF00002.24 EFX03925.1 - 4.7e-07 29.3 11.0 8.1e-07 28.6 10.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EFX03925.1 - 0.0084 15.3 5.8 0.017 14.3 5.8 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor NICE-3 PF07406.11 EFX03925.1 - 0.054 13.5 0.4 0.11 12.5 0.4 1.5 1 0 0 1 1 1 0 NICE-3 protein DAO PF01266.24 EFX03926.1 - 3.8e-38 132.0 1.3 3.8e-38 132.0 1.3 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX03926.1 - 1.9e-09 37.7 0.7 0.002 18.1 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFX03926.1 - 0.00035 19.9 0.0 0.23 10.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX03926.1 - 0.0011 19.1 0.0 0.0039 17.4 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFX03926.1 - 0.0035 16.5 0.0 0.0054 15.9 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX03926.1 - 0.0082 15.2 0.3 0.066 12.3 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EFX03926.1 - 0.0088 14.9 0.0 0.18 10.6 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Sacchrp_dh_NADP PF03435.18 EFX03926.1 - 0.069 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Suc_Fer-like PF06999.12 EFX03927.1 - 3.7e-56 190.1 0.0 4.5e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DUF1751 PF08551.10 EFX03928.1 - 1.6e-07 31.8 0.7 3.1e-07 30.9 0.7 1.5 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EFX03928.1 - 5.6e-06 26.4 1.2 1e-05 25.6 1.2 1.6 1 0 0 1 1 1 1 Rhomboid family DER1 PF04511.15 EFX03928.1 - 0.072 13.0 5.0 0.043 13.7 3.1 1.6 2 0 0 2 2 2 0 Der1-like family LCAT PF02450.15 EFX03929.1 - 0.0065 15.7 0.0 0.026 13.7 0.0 1.8 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EFX03929.1 - 0.055 12.7 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RhoGAP PF00620.27 EFX03930.1 - 2.9e-16 59.6 0.2 7.8e-16 58.3 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.21 EFX03930.1 - 8.2e-14 51.4 0.0 2.4e-13 49.9 0.0 1.9 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EFX03930.1 - 4.3e-07 30.1 0.0 1.3e-06 28.6 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain HRI1 PF16815.5 EFX03930.1 - 0.014 15.1 0.2 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein HRI1 Ribosomal_60s PF00428.19 EFX03930.1 - 0.89 10.2 17.2 0.03 14.9 8.2 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Acetyltransf_3 PF13302.7 EFX03931.1 - 2e-20 73.9 0.0 2.7e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFX03931.1 - 3.5e-06 26.8 1.3 0.037 13.7 0.0 3.1 3 0 0 3 3 3 3 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX03931.1 - 8.7e-06 25.6 0.1 0.042 13.8 0.0 2.3 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_1 PF00583.25 EFX03931.1 - 0.0028 17.9 0.2 0.64 10.3 0.1 2.3 1 1 1 2 2 2 2 Acetyltransferase (GNAT) family WLM PF08325.10 EFX03932.1 - 4.3e-56 190.0 2.0 3e-55 187.2 2.0 2.3 1 1 0 1 1 1 1 WLM domain DZR PF12773.7 EFX03932.1 - 0.12 12.4 6.7 1.4 9.0 6.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon DUF45 PF01863.17 EFX03932.1 - 0.64 10.0 5.0 0.11 12.6 1.2 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF45 Stc1 PF12898.7 EFX03932.1 - 0.73 10.4 3.8 1.5 9.5 0.1 2.5 2 1 0 2 2 2 0 Stc1 domain SR-25 PF10500.9 EFX03932.1 - 6.5 6.3 11.0 3.9 7.0 5.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein ABC2_membrane PF01061.24 EFX03933.1 - 3.9e-79 264.9 48.5 4e-47 160.3 18.2 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EFX03933.1 - 9.4e-41 139.5 0.0 6.9e-20 72.0 0.0 3.1 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EFX03933.1 - 5.9e-16 58.2 0.0 5.9e-16 58.2 0.0 3.6 5 0 0 5 5 3 2 CDR ABC transporter AAA_21 PF13304.6 EFX03933.1 - 1.3e-06 28.4 0.0 0.08 12.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFX03933.1 - 3.1e-06 27.8 0.0 0.019 15.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.7 EFX03933.1 - 4.8e-06 25.9 38.4 8.3e-06 25.1 15.6 3.0 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EFX03933.1 - 1e-05 26.0 0.0 0.063 13.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFX03933.1 - 0.00017 21.5 0.0 0.002 18.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFX03933.1 - 0.0017 18.6 0.0 0.14 12.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFX03933.1 - 0.0033 17.6 0.6 0.12 12.5 0.0 3.3 4 0 0 4 4 3 1 AAA domain AAA_29 PF13555.6 EFX03933.1 - 0.0033 17.1 0.1 0.13 12.0 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EFX03933.1 - 0.0059 16.9 0.1 0.07 13.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain Ribosomal_S28e PF01200.18 EFX03933.1 - 0.013 15.5 0.0 0.047 13.7 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein S28e AAA_30 PF13604.6 EFX03933.1 - 0.024 14.4 0.0 0.87 9.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFX03933.1 - 0.026 14.1 0.0 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1738 PF08401.11 EFX03933.1 - 0.029 14.5 0.1 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1738) AAA PF00004.29 EFX03933.1 - 0.033 14.6 0.1 6.9 7.1 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EFX03933.1 - 0.067 13.3 0.0 8.3 6.5 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_19 PF13245.6 EFX03933.1 - 0.1 12.9 0.0 20 5.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFX03933.1 - 0.12 12.3 0.1 1.3 9.0 0.1 2.5 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EFX03933.1 - 0.15 11.6 0.1 2.8 7.5 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFX03933.1 - 0.16 11.9 0.1 3.8 7.4 0.1 2.5 2 0 0 2 2 2 0 NACHT domain MeaB PF03308.16 EFX03933.1 - 0.24 10.4 0.3 3.6 6.5 0.0 2.5 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CPSF_A PF03178.15 EFX03934.1 - 1.3e-88 297.4 0.0 2.7e-88 296.4 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 EFX03934.1 - 9.6e-16 57.5 0.0 8.8e-15 54.3 0.0 2.2 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Mucin PF01456.17 EFX03934.1 - 0.11 12.5 1.9 1.6 8.7 1.6 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein HSCB_C PF07743.13 EFX03936.1 - 3e-17 62.9 1.7 6.8e-16 58.5 2.0 2.6 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain FAM196 PF15265.6 EFX03936.1 - 0.011 15.2 6.1 0.021 14.3 6.1 1.4 1 0 0 1 1 1 0 FAM196 family Bromo_TP PF07524.13 EFX03940.1 - 2.7e-08 33.7 0.0 4.5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EFX03940.1 - 0.0019 18.2 0.0 0.0028 17.7 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Myb_DNA-bind_4 PF13837.6 EFX03941.1 - 0.09 13.2 0.6 0.79 10.1 0.2 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain PUF PF00806.19 EFX03942.1 - 9.8e-61 198.2 9.2 1.2e-07 31.0 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat TylF PF05711.11 EFX03942.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) DUF2054 PF10218.9 EFX03942.1 - 0.16 12.1 4.0 0.2 11.7 1.1 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2054) FapA PF03961.13 EFX03942.1 - 0.3 9.6 1.2 0.5 8.9 1.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIC PF04977.15 EFX03942.1 - 2.6 7.9 5.8 5.4 6.9 5.8 1.5 1 0 0 1 1 1 0 Septum formation initiator MFS_1 PF07690.16 EFX03943.1 - 3e-29 102.1 19.8 3e-29 102.1 19.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX03943.1 - 2.4e-11 43.2 11.4 2.4e-11 43.2 11.4 2.4 2 1 1 3 3 3 1 Sugar (and other) transporter PUCC PF03209.15 EFX03943.1 - 0.004 16.2 5.4 0.014 14.5 2.7 2.2 2 0 0 2 2 2 1 PUCC protein OATP PF03137.20 EFX03943.1 - 0.0045 15.3 2.4 0.0045 15.3 2.4 2.8 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Elong_Iki1 PF10483.9 EFX03944.1 - 3.8e-91 305.7 0.0 4.4e-91 305.5 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Methyltransf_23 PF13489.6 EFX03945.1 - 8e-21 74.6 0.0 1.2e-20 74.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX03945.1 - 7e-11 42.7 0.0 1.9e-10 41.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX03945.1 - 1.8e-09 37.6 0.0 1.1e-08 35.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX03945.1 - 4.9e-09 36.7 0.0 1.9e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX03945.1 - 1.6e-08 35.2 0.0 5.6e-08 33.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFX03945.1 - 0.0057 16.1 0.0 0.0094 15.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EFX03945.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EFX03945.1 - 0.035 13.8 0.0 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EFX03945.1 - 0.14 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Fer4_15 PF13459.6 EFX03945.1 - 3.1 8.6 4.8 1 10.1 1.4 1.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain Cpn10 PF00166.21 EFX03946.1 - 9.8e-29 99.3 0.0 1.1e-28 99.1 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Fer4 PF00037.27 EFX03948.1 - 1.9e-13 49.6 16.5 6.6e-08 32.0 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EFX03948.1 - 8.3e-13 48.7 9.8 1.3e-12 48.1 9.8 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EFX03948.1 - 2.4e-10 41.2 7.3 9.1e-05 23.3 0.3 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EFX03948.1 - 2.8e-09 36.9 31.3 8.4e-06 25.8 12.2 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFX03948.1 - 1e-08 35.2 20.8 1.6e-06 28.1 11.9 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFX03948.1 - 1.3e-08 34.9 8.7 2.2e-08 34.2 8.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFX03948.1 - 1e-06 29.1 19.3 0.00021 21.7 11.1 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFX03948.1 - 1.5e-06 28.0 17.1 0.00043 20.2 5.4 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EFX03948.1 - 4.1e-06 26.6 11.4 0.0087 16.1 1.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EFX03948.1 - 1.3e-05 25.3 11.7 0.00039 20.7 2.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EFX03948.1 - 0.00061 20.3 12.0 0.075 13.6 13.0 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EFX03948.1 - 0.0062 16.7 5.6 0.57 10.5 0.3 2.2 1 1 1 2 2 2 2 c-SKI Smad4 binding domain ETF_QO PF05187.13 EFX03948.1 - 0.054 13.6 5.0 0.22 11.7 0.4 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_18 PF13746.6 EFX03948.1 - 0.063 13.5 8.5 1.3 9.2 1.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EFX03948.1 - 0.071 13.7 14.8 0.8 10.3 4.3 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 EFX03948.1 - 0.28 12.2 15.5 0.46 11.5 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 EFX03948.1 - 0.82 10.6 11.5 2.8 8.8 1.5 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain polyprenyl_synt PF00348.17 EFX03949.1 - 1.4e-62 211.1 0.0 1.6e-62 210.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase zf-RING_UBOX PF13445.6 EFX03950.1 - 5.1e-07 29.6 1.2 5.1e-07 29.6 1.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFX03950.1 - 4.1e-06 26.6 2.3 8.7e-06 25.6 2.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFX03950.1 - 5.9e-06 26.1 5.8 3.4e-05 23.6 5.9 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX03950.1 - 6e-06 26.0 5.6 9.2e-05 22.2 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX03950.1 - 1.5e-05 24.7 7.3 7.7e-05 22.4 3.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFX03950.1 - 3.7e-05 24.0 6.2 0.00014 22.1 2.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFX03950.1 - 8.2e-05 22.7 2.2 8.2e-05 22.7 2.2 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFX03950.1 - 0.0088 15.9 9.7 0.36 10.7 7.0 3.0 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 PRP3 PF08572.10 EFX03950.1 - 0.061 13.0 0.2 0.061 13.0 0.2 2.3 2 0 0 2 2 2 0 pre-mRNA processing factor 3 (PRP3) TerY_C PF15616.6 EFX03950.1 - 0.13 12.3 0.7 0.38 10.9 0.2 1.9 2 0 0 2 2 2 0 TerY-C metal binding domain zf-RING_10 PF16685.5 EFX03950.1 - 0.16 12.1 3.5 0.097 12.8 1.5 1.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EFX03950.1 - 0.37 11.1 2.5 0.72 10.2 0.5 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain Lar_restr_allev PF14354.6 EFX03950.1 - 4.6 7.7 5.1 4.1 7.8 1.3 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar NDUFA12 PF05071.16 EFX03951.1 - 1.6e-30 105.8 1.9 2e-30 105.5 1.9 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 SAD_SRA PF02182.17 EFX03952.1 - 5.6e-39 133.3 0.0 8.5e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 SAD/SRA domain Beta-lactamase PF00144.24 EFX03953.1 - 2.4e-53 181.5 0.0 3.1e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EFX03953.1 - 3.6e-07 30.6 0.0 8e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Aa_trans PF01490.18 EFX03954.1 - 1.5e-58 198.4 34.7 1.8e-58 198.2 34.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PP2C PF00481.21 EFX03955.1 - 1.2e-82 277.5 0.0 2.1e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SHMT PF00464.19 EFX03956.1 - 1.4e-190 633.1 0.0 1.7e-190 632.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase baeRF_family10 PF18854.1 EFX03956.1 - 0.059 13.6 0.3 0.22 11.8 0.3 1.9 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 DegT_DnrJ_EryC1 PF01041.17 EFX03956.1 - 0.079 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_hydro_47 PF01532.20 EFX03957.1 - 1.9e-105 353.4 0.0 3e-105 352.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 EcKinase PF02958.20 EFX03958.1 - 8.9e-21 74.5 0.0 6.7e-19 68.3 0.0 2.2 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 EFX03958.1 - 1.3e-07 31.8 0.4 1.8e-07 31.3 0.4 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFX03958.1 - 2.6e-07 29.9 0.0 7.2e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) DUF1712 PF08217.11 EFX03959.1 - 6.1e-11 41.5 0.0 1.4e-10 40.3 0.0 1.6 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1712) Umbravirus_LDM PF04817.12 EFX03959.1 - 0.0089 15.4 2.8 0.019 14.3 2.8 1.4 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family PRIMA1 PF16101.5 EFX03959.1 - 8.6 6.4 7.3 2.8 8.0 2.2 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 WD40 PF00400.32 EFX03960.1 - 3e-20 72.2 6.8 6.8e-05 23.6 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX03960.1 - 3.5e-12 46.4 0.0 0.035 14.4 0.0 6.0 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX03960.1 - 0.00041 20.3 0.0 0.13 12.1 0.0 2.5 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EFX03960.1 - 0.0089 14.7 0.3 0.057 12.1 0.1 2.0 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFX03960.1 - 0.027 13.4 0.8 8 5.3 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EFX03960.1 - 0.035 12.7 0.0 2.7 6.4 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ric8 PF10165.9 EFX03961.1 - 4.8e-136 454.5 0.4 6e-136 454.1 0.4 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn CS PF04969.16 EFX03962.1 - 0.00087 20.3 0.0 0.0018 19.2 0.0 1.6 1 1 0 1 1 1 1 CS domain Forkhead_N PF08430.12 EFX03962.1 - 1.9 9.1 13.3 3.1 8.4 13.3 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region DUF3844 PF12955.7 EFX03963.1 - 9.5e-36 122.1 3.4 1.5e-35 121.5 3.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Defensin_like PF10868.8 EFX03963.1 - 9.5 7.1 9.6 20 6.0 9.6 1.5 1 0 0 1 1 1 0 Cysteine-rich antifungal protein 2, defensin-like MWFE PF15879.5 EFX03964.1 - 3.5e-30 103.9 0.1 4.6e-30 103.5 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit DnaJ PF00226.31 EFX03966.1 - 1.7e-20 72.9 1.2 3.1e-20 72.0 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.18 EFX03967.1 - 1.2e-19 70.4 0.0 1.2e-19 70.4 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX03967.1 - 8e-09 35.5 11.4 1.5e-08 34.6 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mso1_Sec1_bdg PF14475.6 EFX03967.1 - 0.15 11.7 0.2 0.38 10.4 0.2 1.7 1 0 0 1 1 1 0 Sec1-binding region of Mso1 Zip PF02535.22 EFX03967.1 - 0.84 8.8 3.6 1.4 8.0 3.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EFX03967.1 - 9.5 6.2 9.7 23 5.0 9.7 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_A4 PF01828.17 EFX03968.1 - 1.4e-81 273.0 12.5 1.6e-81 272.7 12.5 1.1 1 0 0 1 1 1 1 Peptidase A4 family CCT_2 PF09425.10 EFX03968.1 - 0.16 11.9 2.0 0.24 11.3 2.0 1.3 1 0 0 1 1 1 0 Divergent CCT motif USP7_ICP0_bdg PF12436.8 EFX03969.1 - 6.2e-86 287.6 0.2 2e-84 282.7 0.1 2.5 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EFX03969.1 - 1.1e-64 217.9 0.2 2.4e-61 207.0 0.0 3.2 4 0 0 4 4 4 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EFX03969.1 - 6.8e-47 160.1 1.6 1e-46 159.6 1.6 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Tim17 PF02466.19 EFX03969.1 - 2.9e-30 104.9 16.9 6.1e-30 103.9 16.9 1.6 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family UCH_1 PF13423.6 EFX03969.1 - 4.2e-20 72.6 0.2 1.2e-19 71.1 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EFX03969.1 - 2.3e-11 43.9 0.0 7.8e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 MATH domain YukD PF08817.10 EFX03969.1 - 0.0068 17.1 0.0 6.6 7.5 0.0 2.8 2 0 0 2 2 2 2 WXG100 protein secretion system (Wss), protein YukD Sec16_C PF12931.7 EFX03970.1 - 7.6e-110 367.3 0.0 1.1e-109 366.8 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EFX03970.1 - 9e-34 116.6 0.0 2.4e-33 115.2 0.0 1.8 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.7 EFX03970.1 - 1.7e-10 41.5 25.2 3.4e-08 34.0 5.9 4.8 3 1 1 5 5 5 2 Vesicle coat trafficking protein Sec16 N-terminus Tachylectin PF14517.6 EFX03970.1 - 0.081 12.5 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Tachylectin DRMBL PF07522.14 EFX03971.1 - 3e-31 107.9 0.0 5.4e-31 107.0 0.0 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EFX03971.1 - 9.4e-07 28.5 0.0 2.4e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CRAL_TRIO PF00650.20 EFX03972.1 - 3.1e-40 137.5 0.0 4.1e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFX03972.1 - 9.3e-15 54.6 2.7 1.7e-14 53.8 2.7 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFX03972.1 - 0.015 15.5 0.0 0.028 14.6 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain HTH_8 PF02954.19 EFX03972.1 - 0.085 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family GA PF01468.17 EFX03972.1 - 0.16 12.2 0.0 0.47 10.8 0.0 1.8 1 0 0 1 1 1 0 GA module RasGEF PF00617.19 EFX03973.1 - 6.4e-44 150.2 0.1 1.4e-43 149.2 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFX03973.1 - 9.5e-14 51.5 0.0 2.2e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.22 EFX03973.1 - 3.1e-06 26.9 0.0 1.1e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFX03973.1 - 0.063 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Peptidase_M24 PF00557.24 EFX03974.1 - 1.3e-57 194.9 0.0 2.7e-57 193.8 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFX03974.1 - 1.2e-18 67.0 0.0 3.2e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain HisKA_3 PF07730.13 EFX03974.1 - 0.27 11.8 4.0 0.4 11.2 0.8 2.6 2 0 0 2 2 2 0 Histidine kinase Aminotran_4 PF01063.19 EFX03975.1 - 3.5e-24 85.9 0.0 4.4e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Ras PF00071.22 EFX03976.1 - 1.7e-51 174.1 0.0 3.3e-51 173.1 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFX03976.1 - 3.3e-18 66.0 0.0 6e-17 62.0 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX03976.1 - 0.00016 21.2 0.0 0.00056 19.4 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFX03976.1 - 0.011 15.7 0.0 3.5 7.5 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 EFX03976.1 - 0.02 14.4 0.2 0.34 10.4 0.0 2.4 2 1 1 3 3 3 0 Ferrous iron transport protein B AAA_16 PF13191.6 EFX03976.1 - 0.06 13.7 0.0 0.091 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 EFX03976.1 - 0.07 12.7 0.2 0.27 10.8 0.1 2.0 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 EFX03976.1 - 0.085 12.1 0.0 0.19 11.0 0.0 1.6 2 0 0 2 2 2 0 Septin DUF2075 PF09848.9 EFX03976.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SRPRB PF09439.10 EFX03976.1 - 0.1 12.0 0.0 1 8.8 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit CbiA PF01656.23 EFX03976.1 - 0.14 12.2 0.0 0.51 10.4 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Exo_endo_phos PF03372.23 EFX03977.1 - 0.00047 19.8 0.6 0.0019 17.7 0.6 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 EFX03978.1 - 5.4e-29 101.2 84.0 9.9e-22 77.3 44.1 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Herpes_LMP1 PF05297.11 EFX03978.1 - 0.27 10.4 3.0 0.46 9.6 3.0 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PspB PF06667.12 EFX03979.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Phage shock protein B DUF737 PF05300.11 EFX03980.1 - 0.00083 19.8 1.6 0.001 19.5 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF737) Fungal_TACC PF12709.7 EFX03982.1 - 5.9e-11 42.7 0.3 5.9e-11 42.7 0.3 3.4 4 0 0 4 4 4 2 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4407 PF14362.6 EFX03982.1 - 3.4 6.9 24.7 0.11 11.8 1.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) NYD-SP28_assoc PF14775.6 EFX03982.1 - 8.4 6.6 6.1 8.7 6.5 0.1 3.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain adh_short PF00106.25 EFX03983.1 - 3.8e-07 29.7 0.0 4.3e-07 29.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX03983.1 - 1.8e-06 27.7 0.0 1.9e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Vps26 PF03643.15 EFX03984.1 - 1.9e-130 433.8 0.6 2.2e-130 433.6 0.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EFX03984.1 - 0.0033 17.5 0.1 1.2 9.2 0.0 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFX03984.1 - 0.013 16.0 0.1 0.15 12.5 0.0 2.5 2 2 1 3 3 3 0 Arrestin (or S-antigen), C-terminal domain IL17R_D_N PF16742.5 EFX03984.1 - 0.068 13.2 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D HEAT PF02985.22 EFX03985.1 - 6e-05 23.0 0.1 0.84 10.1 0.0 5.8 5 0 0 5 5 5 1 HEAT repeat PfkB PF00294.24 EFX03987.1 - 1e-11 44.7 0.0 2.3e-11 43.6 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase SgrT PF15894.5 EFX03987.1 - 0.14 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Inhibitor of glucose uptake transporter SgrT FAD_binding_3 PF01494.19 EFX03988.1 - 1.3e-15 57.6 0.5 1.2e-09 38.0 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_9 PF13454.6 EFX03988.1 - 0.00022 21.2 0.1 0.002 18.2 0.1 2.4 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFX03988.1 - 0.0011 18.3 0.1 0.0058 15.9 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX03988.1 - 0.0039 17.4 0.0 0.017 15.4 0.0 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX03988.1 - 0.029 14.0 3.0 0.098 12.2 0.1 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFX03988.1 - 0.042 13.1 0.7 0.16 11.2 1.5 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX03988.1 - 0.13 11.0 0.0 0.34 9.6 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein RNA_pol_3_Rpc31 PF11705.8 EFX03989.1 - 1e-61 209.1 1.0 1.3e-61 208.8 1.0 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Glyco_transf_20 PF00982.21 EFX03990.1 - 4.3e-141 470.8 0.0 6e-141 470.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EFX03990.1 - 5.9e-69 231.7 0.0 3.5e-67 226.0 0.0 2.2 1 1 0 1 1 1 1 Trehalose-phosphatase Hydrolase PF00702.26 EFX03990.1 - 0.18 12.0 0.0 0.36 11.1 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AAA PF00004.29 EFX03991.1 - 5.3e-20 72.2 0.0 9.6e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX03991.1 - 0.0018 18.7 0.0 0.0047 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFX03991.1 - 0.0042 17.6 0.1 0.079 13.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX03991.1 - 0.0062 16.8 0.1 0.019 15.2 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EFX03991.1 - 0.013 15.4 0.0 0.042 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFX03991.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Zot PF05707.12 EFX03991.1 - 0.13 11.9 0.1 0.54 9.9 0.0 2.0 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) GHMP_kinases_N PF00288.26 EFX03993.1 - 7.9e-10 38.8 0.0 1.7e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFX03993.1 - 3.3e-06 27.4 0.0 8.2e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal ETC_C1_NDUFA4 PF04800.12 EFX03994.1 - 9.6e-36 121.9 3.1 1.3e-35 121.5 3.1 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region HA2 PF04408.23 EFX03995.1 - 2.6e-14 53.4 0.0 2.6e-14 53.4 0.0 2.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFX03995.1 - 1.7e-13 50.9 0.0 4e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFX03995.1 - 7.9e-11 42.0 0.0 1.4e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EFX03995.1 - 5.6e-08 33.0 0.0 1.6e-07 31.5 0.0 1.8 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 EFX03995.1 - 7e-08 32.8 1.0 3e-07 30.8 0.2 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFX03995.1 - 0.032 14.8 0.0 0.2 12.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 EFX03995.1 - 0.061 12.7 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 KaiC Rad17 PF03215.15 EFX03995.1 - 0.19 11.6 0.0 0.4 10.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain SWI-SNF_Ssr4 PF08549.10 EFX03997.1 - 8.4e-235 781.7 0.0 2e-233 777.2 0.0 2.0 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Adeno_E1A PF02703.14 EFX03997.1 - 0.017 14.7 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 Early E1A protein SPESP1 PF15754.5 EFX03997.1 - 0.064 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 DUF1688 PF07958.11 EFX03998.1 - 4.8e-162 539.5 0.0 5.4e-162 539.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Zn_clus PF00172.18 EFX03999.1 - 4.3e-06 26.8 10.0 6.6e-06 26.2 10.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexokinase_2 PF03727.16 EFX04000.1 - 4e-80 268.7 0.0 5.5e-80 268.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EFX04000.1 - 1.6e-71 240.4 0.0 2.2e-71 239.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Ion_trans PF00520.31 EFX04001.1 - 9e-07 28.4 25.5 0.00011 21.5 25.5 2.2 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 EFX04001.1 - 9.9e-07 27.8 16.4 5e-06 25.5 16.4 1.9 1 1 0 1 1 1 1 Polycystin cation channel DSPn PF14671.6 EFX04003.1 - 1.6e-41 142.0 0.0 4.6e-39 134.1 0.0 2.4 2 0 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EFX04003.1 - 3.3e-16 59.3 0.0 7.6e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFX04003.1 - 2.6e-06 27.2 0.0 5.1e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EFX04003.1 - 0.023 14.3 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 EFX04003.1 - 0.041 13.6 0.1 0.083 12.6 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EFX04003.1 - 0.06 13.5 0.4 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate IDO PF01231.18 EFX04004.1 - 2.1e-161 537.5 0.0 2.5e-161 537.3 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase GGACT PF06094.12 EFX04005.1 - 3.2e-06 27.8 0.0 4.3e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AAA_lid_8 PF17868.1 EFX04005.1 - 0.0041 17.0 0.1 0.0094 15.8 0.1 1.5 2 0 0 2 2 2 1 AAA lid domain DUF4671 PF15710.5 EFX04005.1 - 0.045 12.6 0.1 0.054 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4671) Aldedh PF00171.22 EFX04006.1 - 3.3e-123 411.6 3.7 1.5e-83 280.8 1.7 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family Tyr_Deacylase PF02580.16 EFX04007.1 - 3.5e-51 173.5 0.1 3.9e-51 173.4 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase RhoGAP-FF1 PF16512.5 EFX04007.1 - 0.12 13.0 0.0 0.22 12.2 0.0 1.4 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain GATA PF00320.27 EFX04008.1 - 2.3e-14 52.7 2.3 3.9e-14 52.0 2.3 1.4 1 0 0 1 1 1 1 GATA zinc finger ATG16 PF08614.11 EFX04008.1 - 0.0011 19.2 4.4 0.0035 17.6 4.4 1.8 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Atg14 PF10186.9 EFX04008.1 - 0.13 11.3 2.9 0.2 10.7 2.2 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 EFX04008.1 - 9.1 6.5 9.6 7.1 6.9 6.3 2.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Pribosyl_synth PF14572.6 EFX04009.1 - 1.6e-40 139.1 1.1 2.9e-34 118.7 0.3 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EFX04009.1 - 2e-32 111.6 0.0 6e-32 110.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EFX04009.1 - 1.5e-12 47.3 0.2 2.4e-12 46.6 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GTP_CH_N PF12471.8 EFX04010.1 - 1.1e-88 296.0 0.0 1.8e-88 295.3 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EFX04010.1 - 2e-17 63.3 0.0 2.9e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II TIMELESS_C PF05029.13 EFX04011.1 - 1.1e-15 57.8 43.5 9e-14 51.5 43.5 3.0 1 1 0 1 1 1 1 Timeless protein C terminal region MCM2_N PF12619.8 EFX04011.1 - 0.014 15.7 13.6 0.014 15.7 13.6 5.0 1 1 3 4 4 4 0 Mini-chromosome maintenance protein 2 Acyl-CoA_ox_N PF14749.6 EFX04011.1 - 1.2 9.7 4.1 0.78 10.3 1.5 2.1 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal CTP_transf_like PF01467.26 EFX04012.1 - 4.1e-30 104.8 0.0 7.6e-30 104.0 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like MFS_1 PF07690.16 EFX04014.1 - 2.5e-30 105.6 24.0 2.5e-30 105.6 24.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily TraP PF07296.11 EFX04014.1 - 0.037 13.2 0.3 0.34 10.1 0.1 2.3 2 0 0 2 2 2 0 TraP protein MFS_1_like PF12832.7 EFX04014.1 - 0.04 12.8 0.3 6.2 5.6 0.6 2.4 2 0 0 2 2 2 0 MFS_1 like family ANXA2R PF15721.5 EFX04014.1 - 0.069 13.7 0.2 1 9.9 0.0 2.3 2 0 0 2 2 2 0 Annexin-2 receptor Voldacs PF03517.13 EFX04014.1 - 6.1 7.0 6.8 3.6 7.7 0.4 2.4 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling Cwf_Cwc_15 PF04889.12 EFX04014.1 - 6.2 6.5 15.6 0.55 9.9 1.9 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 EFX04014.1 - 7 6.3 10.3 2.1 8.0 0.3 2.7 3 0 0 3 3 3 0 FAM176 family zf-MYND PF01753.18 EFX04015.1 - 4.9e-11 42.5 13.7 9.4e-11 41.6 13.7 1.5 1 0 0 1 1 1 1 MYND finger PRiA4_ORF3 PF07929.11 EFX04015.1 - 3.9e-09 36.5 0.0 4.9e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein zf-C6H2 PF15801.5 EFX04015.1 - 0.029 14.7 8.8 0.029 14.7 8.8 1.8 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding Meleagrin PF08189.11 EFX04015.1 - 0.17 11.6 6.3 0.074 12.8 3.5 1.9 1 1 0 1 1 1 0 Meleagrin/Cygnin family Lbh PF15317.6 EFX04016.1 - 0.0019 19.0 0.1 0.0089 16.9 0.0 2.1 2 0 0 2 2 2 1 Cardiac transcription factor regulator, Developmental protein Peptidase_M3 PF01432.20 EFX04017.1 - 1.9e-108 363.7 0.0 2.7e-108 363.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 EFX04017.1 - 0.049 13.3 0.2 0.082 12.5 0.2 1.3 1 0 0 1 1 1 0 Peptidase M50B-like p450 PF00067.22 EFX04018.1 - 1.1e-47 162.9 0.0 1.4e-47 162.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S10 PF00450.22 EFX04019.1 - 6.7e-82 276.1 0.0 8.9e-82 275.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase VASt PF16016.5 EFX04020.1 - 4.9e-32 111.5 0.9 1.2e-31 110.2 0.9 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EFX04020.1 - 1.5e-14 54.3 0.0 4e-14 52.9 0.0 1.7 1 1 0 1 1 1 1 BAR domain of APPL family GRAM PF02893.20 EFX04020.1 - 0.047 13.6 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 GRAM domain Glyco_hydro_61 PF03443.14 EFX04021.1 - 3.9e-65 219.6 0.1 3.9e-65 219.6 0.1 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 Pkinase PF00069.25 EFX04022.1 - 3.1e-60 203.8 0.0 1.5e-37 129.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04022.1 - 1.1e-26 93.7 0.0 1.4e-19 70.4 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EFX04022.1 - 1.7e-14 53.9 0.0 3.3e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EFX04022.1 - 3.6e-07 29.8 0.0 0.00024 20.5 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EFX04022.1 - 0.00012 22.1 0.1 0.0076 16.2 0.2 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family PAS_9 PF13426.7 EFX04022.1 - 0.0004 20.6 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain Haspin_kinase PF12330.8 EFX04022.1 - 0.008 15.2 0.0 0.024 13.6 0.0 1.7 1 0 0 1 1 1 1 Haspin like kinase domain PAS PF00989.25 EFX04022.1 - 0.019 14.9 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 0 PAS fold Kdo PF06293.14 EFX04022.1 - 0.056 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-CCHC PF00098.23 EFX04023.1 - 8.8e-43 142.5 59.5 6e-08 32.4 2.5 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EFX04023.1 - 5.9e-10 38.7 39.5 0.16 11.7 1.1 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 EFX04023.1 - 0.00072 19.2 44.4 0.007 16.1 1.0 7.2 4 2 3 7 7 7 5 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 EFX04023.1 - 0.0065 16.4 48.5 0.18 11.8 1.1 6.9 3 2 1 5 5 5 4 Zinc knuckle zf-CCHC_6 PF15288.6 EFX04023.1 - 0.093 12.6 0.1 0.093 12.6 0.1 6.9 6 1 1 7 7 7 0 Zinc knuckle DUF836 PF05768.14 EFX04024.1 - 1.9e-12 47.4 0.0 2.3e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EFX04024.1 - 0.00018 21.7 0.0 0.00035 20.7 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin ADH_zinc_N PF00107.26 EFX04025.1 - 3.3e-32 111.2 0.5 5e-32 110.6 0.5 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX04025.1 - 1.2e-09 39.3 0.0 2.2e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX04025.1 - 8.5e-06 25.6 0.0 2.1e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EFX04025.1 - 0.023 14.2 0.4 0.033 13.6 0.4 1.2 1 0 0 1 1 1 0 short chain dehydrogenase HupF_HypC PF01455.18 EFX04025.1 - 0.49 10.6 2.0 3.4 7.9 0.1 2.9 2 1 1 3 3 3 0 HupF/HypC family TRAUB PF08164.12 EFX04026.1 - 9.4e-29 99.8 0.1 9.4e-29 99.8 0.1 2.7 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EFX04026.1 - 2.9e-24 86.4 1.1 2.9e-24 86.4 1.1 1.9 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor COX16 PF14138.6 EFX04026.1 - 5.4 7.6 7.2 2.8 8.5 0.1 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 DUF3347 PF11827.8 EFX04026.1 - 6.8 6.8 8.2 4.7 7.4 5.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) EMP24_GP25L PF01105.24 EFX04027.1 - 1.1e-40 139.5 0.0 1.4e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 EFX04027.1 - 0.093 10.9 0.1 0.12 10.6 0.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Glyco_hydro_12 PF01670.16 EFX04028.1 - 4.7e-15 56.2 9.5 6e-12 46.0 4.3 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 12 zf_CCCH_4 PF18345.1 EFX04029.1 - 0.001 19.0 0.3 0.001 19.0 0.3 3.5 4 0 0 4 4 4 1 Zinc finger domain zf-CCCH PF00642.24 EFX04029.1 - 0.0022 17.9 0.2 0.0022 17.9 0.2 2.4 2 1 1 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFX04029.1 - 0.059 13.9 0.9 0.059 13.9 0.9 3.5 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger CENP-F_leu_zip PF10473.9 EFX04029.1 - 0.06 13.4 3.1 0.12 12.4 3.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UPF0242 PF06785.11 EFX04029.1 - 0.099 12.7 1.1 0.16 12.1 1.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Med3 PF11593.8 EFX04029.1 - 0.69 9.0 20.9 1.2 8.3 20.9 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-CCCH_3 PF15663.5 EFX04029.1 - 1.6 9.0 6.2 12 6.2 0.1 2.7 1 1 1 2 2 2 0 Zinc-finger containing family 6PGD PF00393.19 EFX04030.1 - 4.4e-127 423.4 0.0 5.5e-127 423.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFX04030.1 - 8.8e-50 169.0 0.0 1.5e-49 168.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFX04030.1 - 0.085 13.4 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF3022 PF11226.8 EFX04031.1 - 0.18 12.3 1.7 0.7 10.4 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3022) Fungal_trans PF04082.18 EFX04032.1 - 1.2e-10 40.8 0.0 1.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04032.1 - 1.7e-07 31.2 7.3 1.7e-07 31.2 7.3 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2076 PF09849.9 EFX04032.1 - 0.036 14.1 5.8 0.078 13.0 5.8 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SARAF PF06682.12 EFX04032.1 - 0.053 13.2 2.2 0.1 12.2 2.2 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Asp PF00026.23 EFX04034.1 - 1.2e-41 143.2 0.1 1.5e-41 142.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX04034.1 - 1.2e-07 32.1 0.7 7e-07 29.7 0.7 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX04034.1 - 0.091 13.4 0.1 2.9 8.6 0.0 2.5 2 0 0 2 2 2 0 Aspartyl protease ILVD_EDD PF00920.21 EFX04035.1 - 2.9e-150 501.3 0.7 3.3e-150 501.1 0.7 1.0 1 0 0 1 1 1 1 Dehydratase family Fungal_trans PF04082.18 EFX04036.1 - 7.3e-14 51.4 0.0 1.1e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04036.1 - 2.9e-09 36.9 5.5 8.2e-09 35.5 5.5 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rep_fac-A_3 PF08661.11 EFX04037.1 - 4.4e-19 68.8 0.1 4.8e-19 68.6 0.1 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 CN_hydrolase PF00795.22 EFX04037.1 - 0.16 11.3 0.1 0.27 10.5 0.0 1.4 2 0 0 2 2 2 0 Carbon-nitrogen hydrolase AA_permease_2 PF13520.6 EFX04038.1 - 3.2e-61 207.4 36.8 4.9e-61 206.8 36.8 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX04038.1 - 3.1e-26 92.0 26.0 3.1e-26 92.0 26.0 2.1 2 0 0 2 2 2 1 Amino acid permease WD40 PF00400.32 EFX04039.1 - 5.8e-45 150.4 19.9 3.8e-10 40.2 0.6 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX04039.1 - 1.5e-18 66.9 0.0 0.00094 19.4 0.0 6.1 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX04039.1 - 1.1e-06 27.9 0.1 2.1 7.3 0.0 5.2 3 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFX04039.1 - 8.5e-05 21.4 4.6 0.07 11.8 0.1 4.0 3 2 2 5 5 5 2 Nucleoporin Nup120/160 Frtz PF11768.8 EFX04039.1 - 0.0006 18.3 0.0 0.018 13.4 0.0 2.1 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 EFX04039.1 - 0.0022 17.9 0.0 3.5 7.7 0.0 4.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 EFX04039.1 - 0.0089 14.8 0.1 3.9 6.1 0.2 2.8 2 1 1 3 3 3 2 Nup133 N terminal like WD40_like PF17005.5 EFX04039.1 - 0.053 12.9 0.0 0.19 11.0 0.0 1.8 2 0 0 2 2 2 0 WD40-like domain Apt1 PF10351.9 EFX04039.1 - 0.098 11.5 7.0 0.12 11.3 7.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain VID27 PF08553.10 EFX04039.1 - 0.23 10.5 0.0 15 4.5 0.0 3.2 4 1 1 5 5 5 0 VID27 C-terminal WD40-like domain LAP1C PF05609.12 EFX04039.1 - 0.38 9.8 7.4 0.49 9.4 7.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Corona_nucleoca PF00937.18 EFX04039.1 - 0.45 9.5 13.2 0.8 8.7 13.2 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein BUD22 PF09073.10 EFX04039.1 - 1 8.6 18.8 1.4 8.2 18.8 1.1 1 0 0 1 1 1 0 BUD22 SPX PF03105.19 EFX04039.1 - 1.9 8.3 17.5 3.2 7.6 17.5 1.3 1 0 0 1 1 1 0 SPX domain Sporozoite_P67 PF05642.11 EFX04039.1 - 2 6.4 7.2 3.2 5.7 7.2 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 EFX04039.1 - 8.5 4.5 16.4 12 4.0 16.4 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc34 PF05158.12 EFX04040.1 - 5.4e-98 328.5 0.0 7.4e-98 328.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_34 PF13601.6 EFX04040.1 - 0.014 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain RPA_C PF08784.11 EFX04040.1 - 0.026 15.2 1.9 0.5 11.0 0.0 3.2 3 1 0 3 3 3 0 Replication protein A C terminal B-block_TFIIIC PF04182.12 EFX04040.1 - 0.038 14.1 0.1 0.11 12.7 0.1 1.8 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC DUF787 PF05619.11 EFX04040.1 - 0.079 12.1 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) Cullin_Nedd8 PF10557.9 EFX04040.1 - 0.17 11.9 0.2 0.73 9.9 0.0 2.1 2 0 0 2 2 2 0 Cullin protein neddylation domain FRG2 PF15315.6 EFX04040.1 - 0.2 11.9 1.2 0.32 11.2 1.2 1.2 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 RRM_1 PF00076.22 EFX04041.1 - 9.2e-16 57.4 0.0 1.5e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) adh_short PF00106.25 EFX04042.1 - 5.3e-31 107.6 0.2 6.4e-31 107.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04042.1 - 6.2e-23 81.6 0.1 8.4e-23 81.1 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX04042.1 - 1.1e-09 38.5 0.1 1.9e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFX04042.1 - 0.00019 20.7 0.1 0.071 12.2 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFX04042.1 - 0.00022 20.8 0.3 0.067 12.6 0.0 2.4 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family LDcluster4 PF18306.1 EFX04042.1 - 0.097 12.3 0.2 0.16 11.5 0.2 1.3 1 0 0 1 1 1 0 SLOG cluster4 family Pro_CA PF00484.19 EFX04043.1 - 1.6e-50 171.5 0.0 2.7e-50 170.7 0.0 1.4 1 0 0 1 1 1 1 Carbonic anhydrase ATG11 PF10377.9 EFX04043.1 - 0.063 13.4 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 Methyltransf_23 PF13489.6 EFX04044.1 - 4.4e-19 68.9 0.0 6.2e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04044.1 - 1.6e-07 31.9 0.0 0.0014 19.3 0.0 2.6 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04044.1 - 1.6e-07 31.8 0.0 1.8e-05 25.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04044.1 - 3e-06 27.9 0.0 3.9e-05 24.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04044.1 - 0.00038 19.9 0.0 0.013 14.8 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFX04044.1 - 0.011 15.5 0.0 1.6 8.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain SUKH-4 PF14435.6 EFX04044.1 - 0.067 13.2 1.7 0.087 12.9 1.0 1.7 1 1 0 1 1 1 0 SUKH-4 immunity protein CbiG_C PF01890.16 EFX04044.1 - 0.18 12.4 0.0 0.32 11.6 0.0 1.5 1 0 0 1 1 1 0 Cobalamin synthesis G C-terminus SURF6 PF04935.12 EFX04045.1 - 6e-31 107.8 30.7 2.7e-17 63.2 10.9 5.3 3 1 1 4 4 4 2 Surfeit locus protein 6 RRP14 PF15459.6 EFX04045.1 - 2.4e-16 60.1 0.2 2.4e-16 60.1 0.2 6.9 4 2 1 5 5 5 1 60S ribosome biogenesis protein Rrp14 GHMP_kinases_N PF00288.26 EFX04046.1 - 7.1e-17 61.4 0.0 1.7e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFX04046.1 - 1.2e-10 41.6 0.0 2.7e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EFX04046.1 - 0.024 14.2 0.1 0.048 13.2 0.1 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature DUF1525 PF07511.11 EFX04046.1 - 0.14 12.3 0.1 0.37 11.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) AltA1 PF16541.5 EFX04047.1 - 2.3e-21 76.7 1.9 2.3e-21 76.7 1.9 1.8 2 0 0 2 2 2 1 Alternaria alternata allergen 1 HIT PF01230.23 EFX04048.1 - 3.9e-23 82.0 0.1 5.1e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFX04048.1 - 8.1e-14 52.1 0.1 1.5e-13 51.2 0.0 1.4 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EFX04048.1 - 3.1e-05 23.8 0.3 5.1e-05 23.1 0.0 1.4 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 DUF3112 PF11309.8 EFX04049.1 - 3.1e-09 36.6 0.3 3.1e-09 36.6 0.3 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) HET PF06985.11 EFX04051.1 - 1.1e-11 45.2 8.4 1.9e-09 38.0 0.9 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Jacalin PF01419.17 EFX04051.1 - 2.1e-06 27.7 0.0 3.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Jacalin-like lectin domain RasGAP PF00616.19 EFX04052.1 - 3.9e-28 98.6 7.4 1.1e-21 77.6 0.0 3.5 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EFX04052.1 - 1.3e-05 25.4 0.0 2.9e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 C2 domain PGAP1 PF07819.13 EFX04053.1 - 3.2e-94 315.0 0.0 5.2e-94 314.3 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFX04053.1 - 4.9e-05 24.0 0.1 4.9e-05 24.0 0.1 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX04053.1 - 0.001 18.8 0.1 0.0096 15.6 0.0 2.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX04053.1 - 0.0032 16.8 0.0 0.007 15.7 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EFX04053.1 - 0.045 13.6 0.0 0.096 12.5 0.0 1.6 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF676 PF05057.14 EFX04053.1 - 0.15 11.5 0.1 0.27 10.7 0.1 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) TNFR_16_TM PF18422.1 EFX04053.1 - 7.9 6.5 5.9 1.1 9.3 0.8 2.2 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain CDC14 PF08045.11 EFX04054.1 - 1.2e-122 408.5 0.3 1.7e-122 408.0 0.3 1.2 1 0 0 1 1 1 1 Cell division control protein 14, SIN component DUF1479 PF07350.12 EFX04056.1 - 2.8e-98 329.4 0.0 3.7e-98 329.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) zf-CCCH PF00642.24 EFX04057.1 - 0.00041 20.2 24.4 0.078 12.9 0.1 5.4 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFX04057.1 - 0.0029 18.3 16.9 0.048 14.4 0.7 4.0 1 1 2 3 3 3 2 Torus domain zf-CCCH_4 PF18044.1 EFX04057.1 - 0.0039 17.0 11.4 0.054 13.3 0.1 3.9 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFX04057.1 - 0.0091 16.0 25.1 0.27 11.4 0.8 5.9 5 1 0 5 5 5 3 Zinc finger domain zf-CCCH_3 PF15663.5 EFX04057.1 - 0.014 15.6 1.4 0.014 15.6 1.4 2.8 1 1 1 2 2 2 0 Zinc-finger containing family 3HCDH_N PF02737.18 EFX04058.1 - 7.1e-54 182.4 1.4 8.8e-54 182.1 1.4 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EFX04058.1 - 2.3e-32 111.4 0.0 5e-32 110.4 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFX04058.1 - 0.0001 22.5 0.7 0.00023 21.4 0.7 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EFX04058.1 - 0.00017 21.8 0.7 0.0003 21.1 0.7 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EFX04058.1 - 0.0059 16.2 1.4 0.0093 15.6 1.1 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX04058.1 - 0.018 14.2 0.1 0.024 13.9 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EFX04058.1 - 0.05 13.0 0.2 0.095 12.1 0.2 1.5 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EFX04058.1 - 0.06 12.9 0.1 0.11 12.1 0.1 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.17 EFX04058.1 - 0.17 12.4 2.8 0.26 11.9 0.9 2.2 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent zf_CCCH_4 PF18345.1 EFX04059.1 - 6.2e-06 26.1 3.8 1.1e-05 25.3 3.8 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFX04059.1 - 0.00038 20.2 1.5 0.00059 19.6 1.5 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EFX04059.1 - 0.003 18.2 0.1 0.003 18.2 0.1 3.9 3 0 0 3 3 3 1 Torus domain zf-CCCH_2 PF14608.6 EFX04059.1 - 0.014 15.8 1.3 0.024 15.1 1.3 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EFX04059.1 - 0.037 14.3 0.4 0.037 14.3 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH PF00642.24 EFX04059.1 - 0.14 12.1 1.4 0.25 11.3 1.4 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2877 PF11392.8 EFX04059.1 - 1.7 9.4 12.3 8.8 7.1 0.9 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2877) SpoIIP PF07454.11 EFX04059.1 - 2.1 7.7 24.0 0.053 13.0 15.1 2.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Zip PF02535.22 EFX04059.1 - 5.4 6.1 8.7 20 4.2 8.7 2.0 1 0 0 1 1 1 0 ZIP Zinc transporter Asparaginase_2 PF01112.18 EFX04060.1 - 9.8e-54 182.4 4.4 5.2e-26 91.4 0.2 3.5 3 1 0 3 3 3 3 Asparaginase Pil1 PF13805.6 EFX04061.1 - 2.7e-109 364.8 2.1 3.2e-109 364.5 2.1 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 APG6_N PF17675.1 EFX04061.1 - 0.05 14.1 1.0 2.2 8.8 2.9 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region SH3_9 PF14604.6 EFX04062.1 - 3.9e-05 23.4 0.0 9.3e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFX04062.1 - 0.016 14.9 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 EFX04062.1 - 0.037 13.6 0.1 0.088 12.4 0.1 1.6 1 0 0 1 1 1 0 SH3 domain TPR_12 PF13424.6 EFX04063.1 - 5.4e-15 55.5 0.9 2.1e-11 43.9 0.2 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFX04063.1 - 1.2e-11 44.0 2.7 2e-05 24.3 0.1 3.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFX04063.1 - 5.9e-08 33.1 0.5 0.015 15.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFX04063.1 - 2.7e-06 27.0 0.4 0.097 12.7 0.0 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFX04063.1 - 0.00066 20.1 1.2 12 6.9 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX04063.1 - 0.00079 19.4 0.1 9.4 6.6 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFX04063.1 - 0.0043 17.8 2.9 1.4 10.0 0.1 3.9 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFX04063.1 - 0.022 14.6 0.1 5.2 7.1 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat Rtt106_N PF18215.1 EFX04063.1 - 0.074 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain TPR_6 PF13174.6 EFX04063.1 - 0.092 13.4 0.2 97 3.9 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFX04063.1 - 0.17 12.5 1.7 6.6 7.5 0.8 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_43 PF04616.14 EFX04064.1 - 1.7e-25 89.9 0.0 2.5e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF3883 PF13020.6 EFX04064.1 - 0.026 14.6 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) CorA PF01544.18 EFX04065.1 - 0.0046 16.3 0.2 0.16 11.3 0.0 2.4 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Flu_M2 PF00599.17 EFX04065.1 - 0.049 13.7 0.1 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M2) Ribosomal_L6 PF00347.23 EFX04066.1 - 3.3e-26 91.8 6.6 1.4e-13 51.3 2.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Glyco_trans_2_3 PF13632.6 EFX04067.1 - 1.8e-19 70.4 0.3 1.8e-19 70.4 0.3 2.3 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFX04067.1 - 2.2e-17 63.7 0.0 3.3e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFX04067.1 - 2.5e-14 53.4 0.0 7.6e-14 51.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 Cellulose_synt PF03552.14 EFX04067.1 - 7.7e-12 44.5 7.4 1.9e-09 36.6 5.9 2.4 1 1 2 3 3 3 2 Cellulose synthase Glyco_transf_21 PF13506.6 EFX04067.1 - 8.9e-10 38.3 0.0 1.4e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 EFX04067.1 - 0.0033 16.1 0.4 0.054 12.1 0.3 2.2 2 0 0 2 2 2 1 Chitin synthase DUF3328 PF11807.8 EFX04069.1 - 5.2e-51 173.5 2.3 6.7e-51 173.2 2.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Fungal_trans PF04082.18 EFX04070.1 - 1.1e-10 41.0 0.1 3.2e-10 39.5 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04070.1 - 5.2e-07 29.7 8.8 1.1e-06 28.6 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4965 PF16335.5 EFX04071.1 - 8.9e-74 246.9 0.4 4.3e-73 244.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 EFX04071.1 - 7.3e-62 208.7 0.2 2e-61 207.3 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF5127 PF17168.4 EFX04071.1 - 1.6e-43 149.1 8.0 2.8e-43 148.3 8.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) Phosphorylase PF00343.20 EFX04072.1 - 0 1060.4 0.0 0 1060.2 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DHquinase_II PF01220.19 EFX04072.1 - 0.095 12.4 0.0 2.8 7.6 0.0 2.4 2 0 0 2 2 2 0 Dehydroquinase class II GST_N PF02798.20 EFX04073.1 - 5.2e-09 36.3 0.0 9.6e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFX04073.1 - 1.6e-06 28.4 0.0 2.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFX04073.1 - 0.00047 20.1 0.0 0.00084 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFX04073.1 - 0.00076 19.7 0.0 0.0012 19.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFX04073.1 - 0.0014 18.8 0.0 0.0022 18.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFX04073.1 - 0.0039 17.5 0.0 0.0072 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.16 EFX04075.1 - 2.5e-25 89.1 45.1 7.6e-18 64.6 25.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX04075.1 - 1.2e-19 70.5 19.9 4.3e-14 52.2 8.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter DUF1754 PF08555.10 EFX04076.1 - 3.8e-10 40.4 8.5 6.6e-10 39.7 8.5 1.4 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) AA_permease PF00324.21 EFX04077.1 - 7.1e-58 196.4 30.9 8.9e-58 196.0 30.9 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EFX04077.1 - 5.7e-20 71.7 0.1 8.2e-08 31.7 0.0 3.3 3 0 0 3 3 3 3 Solute carrier family 12 AA_permease_2 PF13520.6 EFX04077.1 - 1.9e-16 59.9 36.8 2.7e-16 59.4 36.8 1.1 1 0 0 1 1 1 1 Amino acid permease Helicase_C_2 PF13307.6 EFX04078.1 - 1.1e-60 204.8 0.0 2.3e-60 203.7 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFX04078.1 - 2e-42 144.8 0.0 4.6e-42 143.6 0.0 1.6 1 1 0 1 1 1 1 DEAD_2 PhoH PF02562.16 EFX04078.1 - 0.042 13.3 0.1 10 5.5 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Nop14 PF04147.12 EFX04078.1 - 0.082 11.1 11.4 0.12 10.6 11.4 1.1 1 0 0 1 1 1 0 Nop14-like family DEAD PF00270.29 EFX04078.1 - 0.13 12.0 0.0 5.8 6.7 0.0 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase ResIII PF04851.15 EFX04078.1 - 0.18 11.8 0.0 21 5.1 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit FHA PF00498.26 EFX04079.1 - 5.6e-11 42.6 0.0 9.1e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFX04079.1 - 0.0044 17.3 0.0 0.18 12.1 0.0 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Ist1 PF03398.14 EFX04080.1 - 6.6e-60 201.8 0.4 6.6e-60 201.8 0.4 1.8 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway GRAM PF02893.20 EFX04081.1 - 3.5e-34 117.1 0.9 2.1e-20 72.7 0.0 3.3 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 EFX04081.1 - 7.8e-30 103.7 0.0 1.5e-29 102.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 EFX04081.1 - 1.4e-14 54.5 0.0 5e-14 52.7 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EFX04081.1 - 0.0011 19.3 2.5 0.0095 16.3 0.6 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EFX04081.1 - 0.0031 17.8 0.0 0.0078 16.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EFX04081.1 - 0.0036 17.4 0.0 0.0079 16.3 0.0 1.5 1 0 0 1 1 1 1 PH domain UDPGT PF00201.18 EFX04081.1 - 0.047 12.5 0.0 0.086 11.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase zf-H2C2_2 PF13465.6 EFX04082.1 - 1.2e-10 41.3 18.8 6.8e-06 26.3 2.1 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFX04082.1 - 2.1e-09 37.3 23.5 0.0045 17.4 3.8 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX04082.1 - 1.1e-06 29.0 20.2 0.046 14.6 6.1 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger Rad50_zn_hook PF04423.14 EFX04082.1 - 0.0095 15.8 3.3 0.062 13.1 0.8 2.5 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C2H2_9 PF16293.5 EFX04082.1 - 0.011 15.5 2.4 1.3 8.9 0.2 3.2 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-CHCC PF10276.9 EFX04082.1 - 0.036 14.1 4.1 2 8.5 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger domain Zn-ribbon_8 PF09723.10 EFX04082.1 - 0.067 13.3 6.2 0.61 10.3 1.7 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 EFX04082.1 - 0.26 11.6 10.6 1.4 9.3 6.0 2.9 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EFX04082.1 - 0.35 10.9 17.7 0.53 10.3 0.0 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger PyrI_C PF02748.15 EFX04082.1 - 0.93 9.5 3.2 0.57 10.1 0.8 1.8 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_9 PF14369.6 EFX04082.1 - 1.1 9.5 5.2 18 5.7 0.1 2.7 2 1 0 2 2 2 0 zinc-ribbon zf-BED PF02892.15 EFX04082.1 - 1.6 8.9 6.6 0.6 10.2 3.6 1.8 1 1 1 2 2 2 0 BED zinc finger GAGA PF09237.11 EFX04082.1 - 2.1 8.2 5.6 10 6.0 0.2 2.9 1 1 2 3 3 3 0 GAGA factor Zn_Tnp_IS1595 PF12760.7 EFX04082.1 - 6.4 6.8 8.1 8.1 6.5 3.2 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain MFS_1 PF07690.16 EFX04083.1 - 6.4e-19 68.1 17.8 9.9e-19 67.5 17.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PPTA PF01239.22 EFX04084.1 - 7.3e-34 114.5 16.1 9.5e-07 28.4 0.2 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Amdase PF17645.1 EFX04085.1 - 0.022 14.4 0.4 0.062 12.9 0.1 1.7 1 1 1 2 2 2 0 Arylmalonate decarboxylase IF-2B PF01008.17 EFX04086.1 - 3.1e-31 108.6 0.0 6.1e-30 104.4 0.0 2.5 1 1 0 1 1 1 1 Initiation factor 2 subunit family Metallothio_PEC PF02068.16 EFX04087.1 - 0.00018 21.8 18.5 0.056 13.8 6.4 2.5 2 0 0 2 2 2 2 Plant PEC family metallothionein Metallothio_2 PF01439.18 EFX04087.1 - 0.0018 19.1 13.0 0.094 13.6 2.4 2.7 2 0 0 2 2 2 2 Metallothionein Metallothio PF00131.20 EFX04087.1 - 0.9 9.7 24.2 1.2 9.3 4.5 3.2 3 0 0 3 3 3 0 Metallothionein ELO PF01151.18 EFX04088.1 - 8.3e-78 261.4 6.8 1e-77 261.1 6.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family TFIIF_alpha PF05793.12 EFX04089.1 - 0.00026 19.7 61.2 0.0013 17.4 10.4 3.1 2 1 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3535 PF12054.8 EFX04089.1 - 0.19 11.0 0.0 0.19 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3535) AAA PF00004.29 EFX04090.1 - 2.8e-14 53.7 0.0 6.2e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX04090.1 - 1.9e-05 25.1 0.0 4.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFX04090.1 - 0.00028 21.2 0.1 0.0019 18.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EFX04090.1 - 0.0048 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Hydin_ADK PF17213.3 EFX04090.1 - 0.023 15.0 0.1 0.023 15.0 0.1 1.9 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 EFX04090.1 - 0.055 13.9 0.0 0.8 10.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFX04090.1 - 0.17 12.4 0.0 0.58 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain HLH PF00010.26 EFX04091.1 - 6.5e-13 48.4 0.0 3.5e-12 46.1 0.0 2.0 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sugar_tr PF00083.24 EFX04092.1 - 1.7e-75 254.6 25.6 2e-75 254.4 25.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04092.1 - 1.6e-18 66.7 37.1 4.9e-11 42.2 14.0 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF4381 PF14316.6 EFX04092.1 - 0.12 12.6 0.9 0.33 11.2 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) MFS_1_like PF12832.7 EFX04092.1 - 0.17 10.7 17.0 0.02 13.8 7.5 2.9 2 1 1 3 3 3 0 MFS_1 like family PUF PF00806.19 EFX04094.1 - 2.7e-08 33.0 0.0 0.16 11.7 0.0 5.0 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat DIMCO_N PF16844.5 EFX04094.1 - 0.053 13.8 0.3 0.86 10.0 0.1 2.8 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal SYF2 PF08231.12 EFX04095.1 - 5.4e-50 169.9 17.2 5.4e-50 169.9 17.2 2.0 1 1 1 2 2 2 1 SYF2 splicing factor Adenylsucc_synt PF00709.21 EFX04095.1 - 0.43 9.4 3.4 0.51 9.2 0.1 2.1 1 1 1 2 2 2 0 Adenylosuccinate synthetase TIP49 PF06068.13 EFX04096.1 - 1.8e-166 553.6 0.1 2.2e-166 553.3 0.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFX04096.1 - 7.9e-25 86.8 0.6 1.9e-24 85.6 0.6 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EFX04096.1 - 1.7e-10 41.4 1.4 4.3e-07 30.4 0.1 2.6 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFX04096.1 - 1.7e-09 37.6 0.2 9.3e-07 28.7 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFX04096.1 - 0.0001 22.6 0.2 0.12 12.6 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFX04096.1 - 0.00028 21.3 0.1 0.0037 17.7 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EFX04096.1 - 0.00058 20.1 0.5 0.0022 18.3 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFX04096.1 - 0.001 19.4 2.4 0.12 12.7 0.3 2.4 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFX04096.1 - 0.0037 17.3 0.2 0.14 12.2 0.1 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFX04096.1 - 0.0046 17.5 0.2 0.018 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFX04096.1 - 0.0099 15.5 0.1 0.064 12.8 0.1 2.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFX04096.1 - 0.011 15.2 0.1 0.43 9.9 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DnaB_C PF03796.15 EFX04096.1 - 0.015 14.7 0.0 0.035 13.4 0.0 1.6 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 EFX04096.1 - 0.018 14.7 0.1 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFX04096.1 - 0.021 14.1 0.2 0.062 12.6 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 EFX04096.1 - 0.026 14.2 0.5 0.054 13.2 0.1 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein DUF2075 PF09848.9 EFX04096.1 - 0.051 12.8 0.1 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EFX04096.1 - 0.066 12.9 0.4 2.8 7.6 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFX04096.1 - 0.097 12.2 0.1 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Pcc1 PF09341.10 EFX04097.1 - 6.7e-32 109.5 0.9 8.4e-32 109.1 0.9 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 Longin PF13774.6 EFX04099.1 - 6.6e-25 87.0 0.2 1.2e-24 86.2 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EFX04099.1 - 3.3e-13 49.3 0.0 5.3e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF5435 PF17503.2 EFX04099.1 - 0.0098 15.6 0.5 0.043 13.6 0.0 2.0 1 1 1 2 2 2 1 Family of unknown function (DUF5435) Methyltransf_11 PF08241.12 EFX04100.1 - 4.2e-13 49.8 0.0 2.2e-12 47.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04100.1 - 1.1e-07 32.4 0.0 4.3e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04100.1 - 0.00012 22.8 0.2 0.00097 19.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX04100.1 - 0.003 17.4 0.0 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04100.1 - 0.043 13.6 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04100.1 - 0.075 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family APC_u9 PF16633.5 EFX04100.1 - 0.35 12.0 4.1 21 6.3 0.0 2.8 2 0 0 2 2 2 0 Unstructured region on APC between 1st two creatine-rich regions Pro_isomerase PF00160.21 EFX04101.1 - 1.6e-38 132.5 0.1 1.8e-38 132.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PhnA PF03831.14 EFX04101.1 - 0.052 13.4 0.1 0.094 12.6 0.1 1.4 1 0 0 1 1 1 0 PhnA domain zf-MYND PF01753.18 EFX04102.1 - 6.9e-10 38.9 10.6 1.1e-09 38.2 10.6 1.3 1 0 0 1 1 1 1 MYND finger FdhE PF04216.12 EFX04102.1 - 0.0057 16.6 1.9 0.0079 16.1 1.9 1.2 1 0 0 1 1 1 1 Protein involved in formate dehydrogenase formation MFS_1 PF07690.16 EFX04103.1 - 2.6e-33 115.4 44.0 1.1e-27 96.9 20.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX04103.1 - 1.2e-08 34.2 11.6 6.9e-07 28.5 3.5 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_2 PF13347.6 EFX04103.1 - 2.1e-06 26.6 22.6 1.3e-05 23.9 10.1 3.3 2 2 1 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 EFX04103.1 - 0.00025 19.5 2.6 0.007 14.7 0.5 3.2 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EFX04103.1 - 0.0032 16.4 5.6 0.0032 16.4 5.6 2.2 2 0 0 2 2 2 1 MFS_1 like family PBP1_TM PF14812.6 EFX04103.1 - 0.0083 16.5 0.2 0.018 15.4 0.2 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal TRI12 PF06609.13 EFX04103.1 - 0.29 9.5 7.8 0.0094 14.4 1.3 1.8 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DUF2061 PF09834.9 EFX04103.1 - 0.54 10.8 6.6 8.1 7.0 0.1 3.7 4 0 0 4 4 4 0 Predicted membrane protein (DUF2061) DFRP_C PF16543.5 EFX04105.1 - 3.2e-25 88.4 8.6 3.2e-25 88.4 8.6 3.4 3 0 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EFX04105.1 - 2.2e-06 28.3 3.1 2.2e-06 28.3 3.1 3.5 2 1 1 3 3 3 2 Torus domain zf-CCCH PF00642.24 EFX04105.1 - 9.5e-06 25.4 1.0 9.5e-06 25.4 1.0 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFX04105.1 - 2.9e-05 23.8 8.1 0.00051 19.8 2.2 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFX04105.1 - 0.00013 21.9 6.7 0.00013 21.9 6.7 3.0 3 0 0 3 3 3 1 Zinc finger domain Cwf_Cwc_15 PF04889.12 EFX04105.1 - 0.00049 19.9 10.2 0.00049 19.9 10.2 2.9 2 1 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein zf-CCCH_3 PF15663.5 EFX04105.1 - 0.018 15.2 0.5 0.18 12.1 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EFX04105.1 - 0.028 14.9 14.0 0.37 11.4 6.7 2.7 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Utp14 PF04615.13 EFX04105.1 - 0.071 11.7 25.8 0.059 12.0 8.8 2.2 2 0 0 2 2 2 0 Utp14 protein tRNA_int_endo PF01974.17 EFX04106.1 - 1.7e-12 47.2 0.0 4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain GFA PF04828.14 EFX04107.1 - 1.3e-08 35.0 0.1 1.3e-08 35.0 0.1 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme PNTB PF02233.16 EFX04108.1 - 1.9e-159 531.5 29.4 1.9e-159 531.5 29.4 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EFX04108.1 - 4.7e-69 232.0 0.3 4.7e-69 232.0 0.3 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EFX04108.1 - 1.7e-47 161.2 0.0 5.4e-47 159.5 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EFX04108.1 - 5.8e-29 100.4 3.2 5.8e-29 100.4 3.2 5.5 4 1 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch Pyr_redox_2 PF07992.14 EFX04108.1 - 0.0027 17.0 0.9 0.024 13.9 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EFX04108.1 - 0.071 12.5 0.5 0.33 10.3 0.1 2.4 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EFX04108.1 - 0.072 12.2 0.8 0.12 11.4 0.8 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A PRIMA1 PF16101.5 EFX04108.1 - 0.076 13.1 1.0 0.26 11.3 1.0 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Glyco_hydro_125 PF06824.11 EFX04109.1 - 8.5e-178 591.5 0.0 9.8e-178 591.3 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Gp23 PF07068.11 EFX04109.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Major capsid protein Gp23 Synaptobrevin PF00957.21 EFX04110.1 - 5.8e-15 54.9 1.6 8.9e-15 54.3 1.6 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFX04110.1 - 1.3e-12 47.5 0.0 3.2e-12 46.3 0.0 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain WH2 PF02205.20 EFX04111.1 - 5.7e-08 32.3 1.6 2.4e-07 30.3 0.2 2.3 2 0 0 2 2 2 1 WH2 motif 2-Hacid_dh_C PF02826.19 EFX04112.1 - 5.7e-43 146.3 0.4 2.6e-28 98.6 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 EFX04112.1 - 0.0023 18.4 0.0 0.0055 17.2 0.0 1.6 1 1 0 1 1 1 1 XdhC Rossmann domain 3HCDH_N PF02737.18 EFX04112.1 - 0.0027 17.6 0.0 0.0046 16.9 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFX04112.1 - 0.018 15.6 0.0 0.034 14.7 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFX04112.1 - 0.037 14.2 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EFX04112.1 - 0.092 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Gp_dh_N PF00044.24 EFX04112.1 - 0.13 12.6 0.6 0.56 10.6 0.5 2.0 1 1 1 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 EFX04112.1 - 0.14 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Sugar_tr PF00083.24 EFX04113.1 - 7.1e-17 61.4 5.8 1.2e-16 60.6 5.8 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04113.1 - 1.2e-16 60.7 8.1 1.4e-16 60.4 8.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Pol_alpha_B_N PF08418.10 EFX04114.1 - 4.4e-83 279.0 0.1 5.6e-83 278.7 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EFX04114.1 - 3e-39 134.6 0.0 4.2e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B TIMELESS PF04821.14 EFX04115.1 - 1.2e-82 277.3 0.1 1.2e-82 277.3 0.1 2.8 3 0 0 3 3 3 1 Timeless protein BUD22 PF09073.10 EFX04115.1 - 0.026 13.9 9.4 0.045 13.1 9.4 1.3 1 0 0 1 1 1 0 BUD22 DUF1754 PF08555.10 EFX04115.1 - 0.046 14.5 12.1 0.13 13.1 12.1 1.7 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Pox_Ag35 PF03286.14 EFX04115.1 - 0.16 11.8 5.9 0.34 10.7 5.9 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FYDLN_acid PF09538.10 EFX04115.1 - 1.1 10.0 11.7 4.2 8.1 11.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) NOA36 PF06524.12 EFX04115.1 - 1.2 8.4 8.3 2.1 7.6 8.3 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EFX04115.1 - 5.7 7.4 8.2 1.4 9.4 4.3 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NDUFB10 PF10249.9 EFX04116.1 - 0.033 14.7 0.0 0.037 14.5 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.14 EFX04116.1 - 0.11 13.2 0.0 0.18 12.6 0.0 1.3 1 0 0 1 1 1 0 HWE histidine kinase DLH PF01738.18 EFX04117.1 - 4.4e-22 78.7 0.0 5.3e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EFX04117.1 - 0.0005 19.6 0.0 0.001 18.6 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family PVL_ORF50 PF07768.11 EFX04118.1 - 3.2 8.1 6.6 0.35 11.2 1.9 1.8 2 0 0 2 2 2 0 PVL ORF-50-like family NINJA_B PF16136.5 EFX04118.1 - 5.2 7.5 15.5 3.6 8.0 7.3 2.8 2 0 0 2 2 2 0 Putative nuclear localisation signal SUI1 PF01253.22 EFX04119.1 - 8.9e-26 90.2 0.8 1.2e-25 89.8 0.8 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 EFX04119.1 - 0.18 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Apc13p PF05839.11 EFX04121.1 - 3.1e-29 101.0 0.0 6.1e-29 100.0 0.0 1.5 1 0 0 1 1 1 1 Apc13p protein ADH_N PF08240.12 EFX04122.1 - 2e-21 75.9 0.2 4e-21 74.9 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX04122.1 - 3.4e-19 69.1 1.7 4.5e-19 68.7 0.4 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX04122.1 - 0.018 14.4 2.1 0.031 13.6 2.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PALP PF00291.25 EFX04122.1 - 0.019 14.4 1.5 0.031 13.7 1.5 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme DUF1524 PF07510.11 EFX04123.1 - 2.8e-08 33.7 0.0 3.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) AAA_12 PF13087.6 EFX04124.1 - 3e-39 134.7 0.0 1.1e-38 132.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFX04124.1 - 3.7e-38 130.9 0.0 5.4e-14 52.8 0.0 5.0 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EFX04124.1 - 5.5e-21 75.5 37.2 1.7e-19 70.6 0.0 6.9 6 0 0 6 6 5 2 AAA domain AAA_30 PF13604.6 EFX04124.1 - 1.1e-18 67.6 0.8 0.038 13.7 0.0 5.8 5 0 0 5 5 5 5 AAA domain AAA_lid_6 PF17866.1 EFX04124.1 - 5e-17 61.8 3.2 5.4e-07 29.7 0.1 4.1 3 0 0 3 3 3 2 AAA lid domain AAA_19 PF13245.6 EFX04124.1 - 6.3e-12 46.0 3.0 0.0064 16.8 0.0 6.3 5 1 0 5 5 5 3 AAA domain AAA_5 PF07728.14 EFX04124.1 - 1.8e-11 44.2 0.3 0.0038 17.2 0.0 3.9 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFX04124.1 - 2.6e-09 37.5 9.6 0.021 15.1 1.0 6.8 3 3 1 4 4 4 3 AAA domain Mg_chelatase PF01078.21 EFX04124.1 - 6.1e-07 29.0 0.4 0.26 10.6 0.0 3.9 3 0 0 3 3 3 3 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EFX04124.1 - 1.4e-06 28.8 7.0 0.49 10.8 0.0 5.7 4 0 0 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 EFX04124.1 - 2.1e-05 24.4 0.0 2.3 7.9 0.0 3.8 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFX04124.1 - 2.2e-05 24.8 0.1 4.1 7.8 0.0 3.9 3 0 0 3 3 3 2 RNA helicase IstB_IS21 PF01695.17 EFX04124.1 - 2.3e-05 24.2 0.1 1 9.0 0.0 3.8 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_24 PF13479.6 EFX04124.1 - 8.5e-05 22.4 2.0 1 9.0 0.0 3.8 3 0 0 3 3 3 1 AAA domain Torsin PF06309.11 EFX04124.1 - 0.00012 22.1 0.0 6.8 6.8 0.0 3.8 3 0 0 3 3 3 1 Torsin AAA_7 PF12775.7 EFX04124.1 - 0.00032 20.3 1.7 3.1 7.3 0.1 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_33 PF13671.6 EFX04124.1 - 0.00052 20.2 13.3 0.24 11.5 0.0 4.7 5 0 0 5 5 3 2 AAA domain AAA_18 PF13238.6 EFX04124.1 - 0.00081 19.9 11.3 3.1 8.3 0.0 5.1 4 0 0 4 4 4 2 AAA domain NTPase_1 PF03266.15 EFX04124.1 - 0.014 15.3 3.1 4.8 7.1 0.2 3.8 3 0 0 3 3 3 0 NTPase DUF917 PF06032.12 EFX04124.1 - 0.15 10.9 0.2 0.76 8.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF917) Mur_ligase_M PF08245.12 EFX04124.1 - 0.73 9.8 2.7 2.9 7.9 0.1 3.0 3 0 0 3 3 3 0 Mur ligase middle domain TsaE PF02367.17 EFX04124.1 - 1.6 8.8 4.9 34 4.5 0.0 3.8 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 EFX04124.1 - 3.9 7.0 12.1 5.7 6.5 0.0 4.4 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain ADK PF00406.22 EFX04124.1 - 5 7.2 13.2 1.3 9.1 0.2 4.9 5 0 0 5 5 4 0 Adenylate kinase Ntox14 PF15522.6 EFX04125.1 - 0.089 12.2 0.0 0.091 12.2 0.0 1.0 1 0 0 1 1 1 0 Novel toxin 14 APH PF01636.23 EFX04125.1 - 0.19 11.6 0.0 0.2 11.6 0.0 1.0 1 0 0 1 1 1 0 Phosphotransferase enzyme family APH PF01636.23 EFX04126.1 - 8.7e-45 153.5 0.3 1.3e-44 153.0 0.3 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFX04126.1 - 0.0025 17.2 0.0 0.0037 16.6 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase 2-ph_phosp PF04029.14 EFX04127.1 - 0.18 10.9 0.9 0.22 10.7 0.9 1.2 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase RgpF PF05045.12 EFX04128.1 - 0.021 13.6 0.1 0.069 11.9 0.0 1.7 2 0 0 2 2 2 0 Rhamnan synthesis protein F DUF202 PF02656.15 EFX04129.1 - 2.7e-21 75.8 1.6 2.7e-21 75.8 1.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF998 PF06197.13 EFX04129.1 - 0.0012 18.5 5.2 0.0019 17.8 5.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF998) DUF2975 PF11188.8 EFX04129.1 - 0.08 12.8 1.7 0.21 11.5 1.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) SAM_2 PF07647.17 EFX04130.1 - 1.1e-06 28.6 0.0 3.1e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EFX04130.1 - 0.00021 21.7 0.0 0.74 10.3 0.0 2.6 2 0 0 2 2 2 2 PH domain CENP-B_dimeris PF09026.10 EFX04131.1 - 0.55 10.6 10.7 5.6 7.4 7.8 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3245 PF11595.8 EFX04131.1 - 3.5 8.1 6.2 0.42 11.1 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) adh_short PF00106.25 EFX04133.1 - 2.1e-34 118.7 0.3 9.7e-27 93.7 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04133.1 - 2.8e-21 76.2 0.1 2.3e-19 69.9 0.1 2.3 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EFX04133.1 - 5.1e-05 23.3 1.4 0.00035 20.5 0.3 2.4 1 1 1 2 2 2 1 NAD(P)H-binding KR PF08659.10 EFX04133.1 - 0.00019 21.4 0.2 0.53 10.2 0.0 2.2 1 1 1 2 2 2 2 KR domain Epimerase PF01370.21 EFX04133.1 - 0.016 14.7 0.4 0.077 12.4 0.4 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFX04133.1 - 0.03 13.4 0.3 0.35 9.9 0.1 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain DUF1776 PF08643.10 EFX04133.1 - 0.048 13.0 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 EFX04133.1 - 0.35 10.7 1.4 0.76 9.6 0.1 2.1 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF5320 PF17253.2 EFX04134.1 - 0.015 16.4 1.1 0.027 15.5 1.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5320) PseudoU_synth_1 PF01416.20 EFX04135.1 - 1.4e-34 118.8 0.0 1.1e-31 109.5 0.0 2.4 2 1 0 2 2 2 2 tRNA pseudouridine synthase Ras PF00071.22 EFX04136.1 - 1.3e-37 128.8 0.0 2.3e-24 85.8 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFX04136.1 - 9.7e-11 41.9 0.0 1.9e-10 41.0 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFX04136.1 - 0.0052 16.9 0.0 0.0078 16.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase PRK PF00485.18 EFX04136.1 - 0.17 11.6 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family 4HBT_3 PF13622.6 EFX04137.1 - 2.3e-46 159.1 0.0 3.2e-46 158.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily RabGAP-TBC PF00566.18 EFX04138.1 - 9.2e-31 107.2 1.5 3e-26 92.4 0.0 2.7 3 0 0 3 3 3 2 Rab-GTPase-TBC domain dsDNA_bind PF01984.20 EFX04138.1 - 0.19 12.0 8.7 22 5.3 0.0 2.3 2 0 0 2 2 2 0 Double-stranded DNA-binding domain TFIIA PF03153.13 EFX04138.1 - 3.7 7.4 11.6 0.2 11.6 5.9 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ribosomal_L38e PF01781.18 EFX04139.1 - 1.2e-32 111.7 3.0 1.5e-32 111.5 3.0 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Cyclophil_like2 PF18050.1 EFX04139.1 - 0.0091 15.9 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin-like family Usp PF00582.26 EFX04140.1 - 8.5e-14 52.3 0.2 4.1e-06 27.4 0.0 2.9 3 0 0 3 3 3 2 Universal stress protein family BCDHK_Adom3 PF10436.9 EFX04141.1 - 0.051 13.4 0.3 0.95 9.3 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase K-box PF01486.17 EFX04141.1 - 0.078 13.2 3.0 0.51 10.5 1.2 2.4 2 0 0 2 2 2 0 K-box region RecX PF02631.16 EFX04141.1 - 0.098 13.1 0.1 0.34 11.4 0.1 1.9 1 0 0 1 1 1 0 RecX family Glyco_hydro_17 PF00332.18 EFX04143.1 - 1.3e-05 25.0 0.5 2.1e-05 24.3 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Romo1 PF10247.9 EFX04143.1 - 0.099 13.0 2.1 0.33 11.3 2.1 1.9 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 CHASE6_C PF17150.4 EFX04143.1 - 0.14 12.8 0.0 0.31 11.7 0.0 1.5 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain AF-4 PF05110.13 EFX04143.1 - 1 7.3 9.2 1.3 7.0 9.2 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Serglycin PF04360.12 EFX04143.1 - 6 6.8 6.7 3.5 7.6 4.2 1.9 2 0 0 2 2 2 0 Serglycin LCCL PF03815.19 EFX04144.1 - 1.7e-16 60.1 0.0 2.8e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 LCCL domain MFS_1_like PF12832.7 EFX04144.1 - 0.0046 15.9 0.6 2 7.2 0.0 2.2 2 0 0 2 2 2 2 MFS_1 like family zf-C2H2_aberr PF17017.5 EFX04145.1 - 0.58 10.3 5.4 0.45 10.6 0.2 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EFX04145.1 - 9.1 7.4 16.8 11 7.1 0.4 5.0 3 2 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EFX04145.1 - 9.1 6.9 11.7 0.042 14.3 1.0 2.9 3 0 0 3 3 3 0 Zinc-finger double domain SAP18 PF06487.12 EFX04146.1 - 2.5e-38 131.4 0.0 3e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) IU_nuc_hydro PF01156.19 EFX04147.1 - 1.5e-20 74.0 0.0 1.7e-20 73.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PRELI PF04707.14 EFX04148.1 - 1.4e-21 77.0 0.1 4.6e-18 65.5 0.0 2.2 1 1 1 2 2 2 2 PRELI-like family Med26 PF08711.11 EFX04148.1 - 0.12 12.4 0.3 2 8.5 0.1 2.5 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Chitin_synth_2 PF03142.15 EFX04149.1 - 3.3e-246 818.0 2.1 8.6e-246 816.6 2.2 1.6 2 0 0 2 2 2 1 Chitin synthase Myosin_head PF00063.21 EFX04149.1 - 2.7e-68 230.8 0.0 4.9e-67 226.7 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 EFX04149.1 - 5.4e-17 61.7 0.4 1.3e-13 50.8 0.1 3.9 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EFX04149.1 - 7.2e-17 61.1 0.2 4.4e-16 58.5 0.4 2.2 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EFX04149.1 - 9.6e-13 48.5 3.8 9.6e-13 48.5 3.8 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFX04149.1 - 2e-10 41.0 0.0 5.5e-10 39.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFX04149.1 - 0.00023 21.0 0.0 0.091 12.6 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 TFIID-18kDa PF02269.16 EFX04150.1 - 3.7e-19 68.5 0.0 6.1e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 EFX04150.1 - 0.0064 16.9 0.1 0.026 14.9 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 EFX04150.1 - 0.007 16.8 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Bromo_TP PF07524.13 EFX04150.1 - 0.0088 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 EFX04150.1 - 0.014 15.5 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EFX04150.1 - 0.019 15.2 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFX04150.1 - 0.052 13.9 0.0 0.086 13.2 0.0 1.3 1 0 0 1 1 1 0 CENP-S protein Anoctamin PF04547.12 EFX04153.1 - 7.2e-116 387.7 4.5 8.8e-116 387.4 4.5 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel NACHT PF05729.12 EFX04154.1 - 7.1e-05 22.8 3.5 0.00021 21.2 0.3 2.8 2 1 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EFX04154.1 - 0.14 12.5 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TRAM_LAG1_CLN8 PF03798.16 EFX04155.1 - 3.5e-37 128.1 11.9 3.5e-37 128.1 11.9 1.5 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EFX04155.1 - 1.4e-17 63.1 3.2 3.7e-17 61.7 0.0 2.6 2 1 0 2 2 2 1 TRAM1-like protein DUF4834 PF16118.5 EFX04155.1 - 0.057 14.4 0.6 1.9 9.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) adh_short PF00106.25 EFX04156.1 - 1.8e-40 138.5 0.0 2.3e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04156.1 - 4.6e-34 118.0 0.0 6.7e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX04156.1 - 2.5e-12 47.1 0.1 3.6e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFX04156.1 - 0.18 11.1 0.0 0.25 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Pyridoxal_deC PF00282.19 EFX04157.1 - 4.2e-64 216.6 0.0 7.9e-64 215.7 0.0 1.4 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EFX04157.1 - 0.0005 19.4 0.0 0.00073 18.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EFX04157.1 - 0.001 18.1 0.0 0.0018 17.3 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V MFS_1 PF07690.16 EFX04158.1 - 3.2e-28 98.7 22.1 3.2e-28 98.7 22.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX04158.1 - 2.4e-08 33.3 6.2 2.4e-08 33.3 6.2 3.1 2 1 0 2 2 2 1 Sugar (and other) transporter TMEM234 PF10639.9 EFX04158.1 - 0.048 13.7 1.6 10 6.2 0.8 2.6 2 0 0 2 2 2 0 Putative transmembrane family 234 Wzy_C PF04932.15 EFX04158.1 - 0.078 12.6 0.1 0.078 12.6 0.1 3.6 4 0 0 4 4 4 0 O-Antigen ligase DUF4231 PF14015.6 EFX04158.1 - 0.15 12.5 2.7 0.2 12.1 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) DUF21 PF01595.20 EFX04158.1 - 2.7 7.7 7.3 6.6 6.4 0.4 2.7 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain Fungal_trans PF04082.18 EFX04159.1 - 0.0023 17.0 0.1 0.0039 16.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M19 PF01244.21 EFX04160.1 - 1.2e-97 327.0 0.0 1.5e-97 326.6 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Fungal_trans_2 PF11951.8 EFX04161.1 - 8.5e-81 271.7 0.0 1.1e-80 271.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04161.1 - 2.4e-05 24.4 10.0 2.4e-05 24.4 10.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SoxE PF06525.11 EFX04161.1 - 0.17 11.3 0.1 0.36 10.3 0.1 1.4 1 0 0 1 1 1 0 Sulfocyanin (SoxE) domain PSCyt3 PF07627.11 EFX04161.1 - 3.2 8.1 6.0 5 7.5 4.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) Tir_receptor_C PF07489.11 EFX04161.1 - 5.3 6.9 10.8 15 5.5 10.8 1.7 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EFX04161.1 - 6.6 4.6 5.9 9.7 4.0 5.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIID-18kDa PF02269.16 EFX04162.1 - 6.1e-24 83.9 0.4 2.1e-23 82.2 0.0 2.0 3 0 0 3 3 3 1 Transcription initiation factor IID, 18kD subunit LCM PF04072.14 EFX04162.1 - 8.6e-20 71.5 0.0 2.3e-18 66.8 0.0 2.8 2 1 0 2 2 2 1 Leucine carboxyl methyltransferase Myc_N PF01056.18 EFX04162.1 - 0.088 12.7 0.5 0.17 11.8 0.5 1.4 1 0 0 1 1 1 0 Myc amino-terminal region TAFII28 PF04719.14 EFX04162.1 - 0.18 12.0 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Endosulfine PF04667.17 EFX04163.1 - 3.1e-27 94.5 0.0 4.9e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Cyclin_N PF00134.23 EFX04164.1 - 1.1e-09 38.1 0.1 1.8e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain TPR_1 PF00515.28 EFX04165.1 - 1.8e-36 122.5 27.1 0.0003 20.5 0.1 11.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 EFX04165.1 - 1.1e-28 96.9 38.2 0.0033 17.4 0.1 11.8 12 0 0 12 12 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFX04165.1 - 5.4e-17 60.5 29.5 0.0099 16.0 0.1 10.4 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFX04165.1 - 6.1e-17 61.0 22.0 0.0013 18.4 0.0 8.8 6 1 2 8 8 8 6 TPR repeat TPR_12 PF13424.6 EFX04165.1 - 1.2e-16 60.7 25.6 0.0029 17.9 0.3 8.4 4 3 5 9 9 9 7 Tetratricopeptide repeat TPR_16 PF13432.6 EFX04165.1 - 2.4e-11 44.1 29.6 0.003 18.2 0.4 8.0 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFX04165.1 - 2.8e-11 43.0 7.9 2.5 8.7 0.1 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFX04165.1 - 7.9e-09 35.5 8.5 7.3e-05 22.8 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFX04165.1 - 4.3e-08 33.5 24.5 4.6e-05 23.8 0.5 6.7 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX04165.1 - 6.2e-08 32.8 18.0 0.039 14.8 0.3 8.9 5 4 5 10 10 10 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFX04165.1 - 1.5e-06 27.9 1.0 4.4e-06 26.3 0.2 2.2 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 EFX04165.1 - 2.4e-06 27.1 23.2 0.18 11.9 0.1 8.9 8 1 1 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFX04165.1 - 4.5e-06 26.8 16.0 0.0061 16.8 0.2 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 MAS20 PF02064.15 EFX04165.1 - 0.00011 22.3 4.6 0.14 12.3 1.1 4.0 3 0 0 3 3 3 1 MAS20 protein import receptor SHNi-TPR PF10516.9 EFX04165.1 - 0.00028 20.3 1.5 1.3 8.5 0.0 3.9 3 0 0 3 3 3 2 SHNi-TPR PGA2 PF07543.12 EFX04165.1 - 0.037 14.0 2.7 0.1 12.6 2.7 1.7 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF3856 PF12968.7 EFX04165.1 - 0.075 13.1 13.4 5.4 7.1 0.0 6.0 5 2 1 6 6 6 0 Domain of Unknown Function (DUF3856) TPR_10 PF13374.6 EFX04165.1 - 0.22 11.4 0.1 0.22 11.4 0.1 8.0 10 0 0 10 10 9 0 Tetratricopeptide repeat MIT PF04212.18 EFX04165.1 - 1.5 9.0 19.0 14 5.9 0.1 6.3 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 EFX04165.1 - 8.7 5.7 10.1 1.7 8.0 0.5 3.8 4 1 1 5 5 5 0 Meiosis protein SPO22/ZIP4 like WD40 PF00400.32 EFX04166.1 - 6.2e-14 52.2 4.7 0.0066 17.3 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX04166.1 - 1.1e-06 28.9 0.0 0.023 15.0 0.0 5.0 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFX04166.1 - 3e-06 26.8 0.0 5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain NUP214 PF16755.5 EFX04166.1 - 0.012 14.8 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Nup160 PF11715.8 EFX04166.1 - 0.061 12.0 0.1 0.095 11.3 0.1 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 zf-CCCH PF00642.24 EFX04167.1 - 0.011 15.6 5.2 0.018 15.0 5.2 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFX04167.1 - 1.8 8.5 5.5 3 7.7 5.5 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFX04167.1 - 2.7 8.2 10.9 4.6 7.4 10.9 1.4 1 0 0 1 1 1 0 Zinc finger domain MFS_1 PF07690.16 EFX04168.1 - 3.7e-47 160.9 25.5 3.1e-43 148.1 16.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX04168.1 - 1.5e-12 47.1 10.1 1.5e-12 47.1 10.1 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EFX04168.1 - 2.6e-08 32.7 4.4 4.2e-08 32.1 4.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EFX04168.1 - 5.7e-06 25.0 4.5 1.1e-05 24.0 4.5 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_1_like PF12832.7 EFX04168.1 - 0.00086 18.3 0.9 0.25 10.1 0.0 2.8 1 1 1 3 3 3 2 MFS_1 like family LRR_6 PF13516.6 EFX04169.1 - 4.3e-11 41.9 10.2 0.00064 19.6 0.0 6.6 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 EFX04169.1 - 5.2e-08 33.1 8.5 0.094 13.2 0.0 5.3 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFX04169.1 - 0.00028 21.0 0.1 14 6.7 0.1 5.3 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.6 EFX04169.1 - 0.00055 19.7 8.6 4.9 7.0 0.0 5.0 4 1 0 4 4 4 3 Leucine rich repeat LETM1 PF07766.13 EFX04169.1 - 0.021 14.2 0.1 0.021 14.2 0.1 1.6 2 0 0 2 2 2 0 LETM1-like protein YL1 PF05764.13 EFX04169.1 - 0.3 11.2 14.3 0.47 10.5 14.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DARPP-32 PF05395.12 EFX04169.1 - 0.66 10.2 13.7 1.3 9.2 13.7 1.4 1 1 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 NOA36 PF06524.12 EFX04169.1 - 7.1 5.9 10.5 11 5.3 10.5 1.2 1 0 0 1 1 1 0 NOA36 protein UPRTase PF14681.6 EFX04170.1 - 3.7e-54 183.3 0.0 4.3e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EFX04170.1 - 3.3e-05 23.5 0.0 4.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain TFIIA PF03153.13 EFX04171.1 - 0.0052 16.8 7.8 0.0078 16.3 7.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit YL1 PF05764.13 EFX04171.1 - 1.4 9.0 9.1 0.16 12.1 4.1 1.8 2 0 0 2 2 2 0 YL1 nuclear protein Nop14 PF04147.12 EFX04171.1 - 1.8 6.7 7.8 2.7 6.1 7.8 1.2 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 EFX04171.1 - 4 7.0 9.1 6.1 6.3 9.1 1.2 1 0 0 1 1 1 0 PPP4R2 PRCC PF10253.9 EFX04172.1 - 3 8.6 7.7 0.13 13.1 0.5 2.3 2 2 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting SPX PF03105.19 EFX04172.1 - 9.6 6.0 22.6 3.5 7.5 4.3 2.5 2 0 0 2 2 2 0 SPX domain RNase_PH PF01138.21 EFX04173.1 - 1.3e-33 116.3 0.2 2.3e-33 115.5 0.2 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF4611 PF15387.6 EFX04173.1 - 0.0011 19.1 4.0 0.34 11.1 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4611) DUF4813 PF16072.5 EFX04173.1 - 8 6.0 14.9 62 3.1 11.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4813) Pyr_redox_2 PF07992.14 EFX04174.1 - 2.9e-08 33.3 0.1 1.7e-06 27.5 0.4 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase PAXNEB PF05625.11 EFX04175.1 - 4.3e-74 249.9 0.0 6.6e-74 249.3 0.0 1.2 1 0 0 1 1 1 1 PAXNEB protein CDO_I PF05995.12 EFX04176.1 - 6.7e-40 136.1 0.0 8.5e-40 135.8 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EFX04176.1 - 0.032 13.7 0.2 0.032 13.7 0.2 1.6 2 1 0 2 2 2 0 PCO_ADO CDP-OH_P_transf PF01066.21 EFX04177.1 - 3.7e-12 46.8 0.2 3.7e-12 46.8 0.2 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase NAP PF00956.18 EFX04178.1 - 1.8e-21 76.5 0.1 5.7e-19 68.3 0.0 3.2 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Rhabdo_ncap PF00945.18 EFX04178.1 - 0.19 10.5 2.9 0.32 9.8 2.9 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein BUD22 PF09073.10 EFX04178.1 - 5.7 6.2 23.1 7.4 5.8 23.1 1.1 1 0 0 1 1 1 0 BUD22 IF3_C PF00707.22 EFX04180.1 - 9.8e-11 41.5 0.2 1.9e-10 40.6 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 EFX04180.1 - 0.016 14.8 0.1 0.028 14.1 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial translation initiation factor SUZ PF12752.7 EFX04180.1 - 3.8 8.4 6.6 0.68 10.7 0.3 2.9 3 0 0 3 3 3 0 SUZ domain NPR3 PF03666.13 EFX04181.1 - 3.1e-73 247.2 0.0 5.3e-71 239.8 0.0 2.0 1 1 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 PARP PF00644.20 EFX04182.1 - 9.6e-12 44.9 0.0 1.7e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Transp_cyt_pur PF02133.15 EFX04183.1 - 1.6e-85 287.5 46.2 2e-85 287.2 46.2 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Lysine_decarbox PF03641.14 EFX04184.1 - 1.2e-25 90.1 0.0 2.3e-25 89.2 0.0 1.5 1 1 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFX04184.1 - 0.0035 17.0 1.8 0.0089 15.6 0.5 2.1 1 1 1 2 2 2 1 SLOG cluster4 family LSDAT_prok PF18171.1 EFX04184.1 - 0.076 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote GMC_oxred_N PF00732.19 EFX04185.1 - 2e-39 135.7 0.0 4.3e-39 134.6 0.0 1.5 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX04185.1 - 2.2e-23 83.4 0.0 4.9e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EFX04185.1 - 4.3e-05 23.6 1.0 0.00013 22.1 1.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX04185.1 - 5.1e-05 22.5 1.5 0.00028 20.1 1.3 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX04185.1 - 7.1e-05 22.2 0.1 0.00012 21.4 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFX04185.1 - 0.00017 20.9 0.1 0.00028 20.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFX04185.1 - 0.0024 16.7 0.2 0.0072 15.1 0.3 1.7 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EFX04185.1 - 0.0049 16.1 0.1 0.0091 15.3 0.1 1.4 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EFX04185.1 - 0.017 14.7 0.6 0.073 12.6 0.5 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFX04185.1 - 0.034 13.5 0.9 0.048 13.0 0.9 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFX04185.1 - 0.081 13.5 1.5 0.16 12.5 1.5 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF5521 PF17659.1 EFX04186.1 - 0.46 8.3 2.5 0.78 7.5 2.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5521) CENP-B_dimeris PF09026.10 EFX04186.1 - 8.9 6.8 8.9 7.6 7.0 0.5 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TBP PF00352.21 EFX04187.1 - 4.8e-66 218.7 0.1 1.2e-32 111.7 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EFX04187.1 - 0.00083 19.4 0.0 0.24 11.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EFX04187.1 - 0.13 12.0 0.1 0.72 9.7 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) Pkinase PF00069.25 EFX04188.1 - 7.9e-76 254.9 0.0 1.1e-75 254.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04188.1 - 6.9e-31 107.5 0.0 5.6e-22 78.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFX04188.1 - 3e-07 30.1 0.1 0.2 10.9 0.0 3.2 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EFX04188.1 - 0.0056 15.5 0.5 0.014 14.2 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFX04188.1 - 0.033 13.5 0.0 0.057 12.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFX04188.1 - 0.092 12.6 0.0 2.4 8.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFX04188.1 - 0.15 11.0 0.0 0.53 9.2 0.0 1.9 3 0 0 3 3 3 0 Haspin like kinase domain SKI PF01202.22 EFX04189.1 - 5.5e-20 72.1 0.5 9.8e-20 71.3 0.1 1.6 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 EFX04189.1 - 3.2e-10 40.1 0.0 7.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain DHquinase_I PF01487.15 EFX04189.1 - 6.5e-10 39.7 0.0 1.6e-09 38.4 0.0 1.6 2 0 0 2 2 2 1 Type I 3-dehydroquinase Shikimate_DH PF01488.20 EFX04189.1 - 1.1e-07 32.0 0.0 2.5e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 EFX04189.1 - 0.00033 20.4 0.1 0.0007 19.3 0.1 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain zf-U1 PF06220.12 EFX04190.1 - 1.5e-17 63.1 3.1 2.2e-17 62.5 3.1 1.3 1 0 0 1 1 1 1 U1 zinc finger DNA_pol_A_exo1 PF01612.20 EFX04191.1 - 5.3e-12 45.8 0.0 8e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_S7 PF00177.21 EFX04192.1 - 5.2e-24 84.6 0.0 8e-24 84.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Zn_clus PF00172.18 EFX04193.1 - 1.4e-05 25.1 11.7 3e-05 24.1 11.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EFX04194.1 - 3.9e-51 174.2 0.0 1.6e-50 172.3 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 UPF0052 PF01933.18 EFX04195.1 - 2.8e-42 144.9 0.0 4.9e-42 144.2 0.0 1.4 1 1 0 1 1 1 1 Uncharacterised protein family UPF0052 Btz PF09405.10 EFX04195.1 - 8.8e-25 87.5 0.4 8.8e-25 87.5 0.4 2.4 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding AMP-binding PF00501.28 EFX04197.1 - 4e-75 253.0 0.1 5.1e-75 252.7 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EFX04197.1 - 6.1e-18 64.5 0.5 1.4e-17 63.3 0.2 1.8 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EFX04197.1 - 2.8e-13 50.6 0.0 8.8e-13 49.0 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SNRNP27 PF08648.12 EFX04198.1 - 3.8e-28 97.3 2.3 7.6e-28 96.4 2.3 1.5 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins NACHT PF05729.12 EFX04199.1 - 0.0027 17.6 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFX04199.1 - 0.018 15.3 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4130 PF13566.6 EFX04199.1 - 0.039 14.0 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 NB-ARC PF00931.22 EFX04199.1 - 0.1 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain MFS_1 PF07690.16 EFX04201.1 - 1.8e-28 99.5 65.9 1.8e-25 89.6 61.6 4.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX04201.1 - 6.4e-05 21.6 19.4 0.00073 18.1 19.4 2.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFX04201.1 - 0.00084 18.3 41.7 0.002 17.0 19.7 4.4 2 2 1 4 4 4 2 Sugar (and other) transporter Adap_comp_sub PF00928.21 EFX04202.1 - 1.4e-15 57.4 0.0 2.1e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFX04202.1 - 3.6e-08 33.5 0.0 5.9e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 EFX04202.1 - 0.003 17.9 0.2 0.0062 16.9 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) RNase_PH PF01138.21 EFX04203.1 - 6.2e-26 91.4 0.0 1.8e-25 90.0 0.0 1.7 1 1 1 2 2 2 1 3' exoribonuclease family, domain 1 Mg_trans_NIPA PF05653.14 EFX04204.1 - 2.1e-79 266.7 17.6 2.5e-79 266.5 17.6 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EFX04204.1 - 0.0021 18.3 7.4 0.0021 18.3 7.4 2.3 2 0 0 2 2 2 2 EamA-like transporter family PDZ_6 PF17820.1 EFX04206.1 - 8.3e-05 22.4 0.0 0.00047 19.9 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Peptidase_M61 PF05299.12 EFX04206.1 - 0.0007 20.0 0.1 0.0041 17.5 0.1 2.1 1 1 0 1 1 1 1 M61 glycyl aminopeptidase PDZ PF00595.24 EFX04206.1 - 0.0093 16.3 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EFX04206.1 - 0.16 12.4 0.0 0.41 11.0 0.0 1.7 1 0 0 1 1 1 0 PDZ domain peroxidase PF00141.23 EFX04208.1 - 3.4e-24 85.8 0.1 5.3e-24 85.2 0.1 1.2 1 0 0 1 1 1 1 Peroxidase PSI_PSAK PF01241.18 EFX04208.1 - 0.014 15.4 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 Photosystem I psaG / psaK Haspin_kinase PF12330.8 EFX04209.1 - 1.4e-31 109.8 0.0 2e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFX04209.1 - 0.0019 18.2 1.1 0.0049 16.8 1.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Cas_Cas5d PF09704.10 EFX04209.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas5) Not3 PF04065.15 EFX04210.1 - 2.3e-89 298.8 21.2 3.6e-89 298.2 21.2 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EFX04210.1 - 1.3e-41 141.8 10.4 2.8e-41 140.7 10.4 1.6 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.6 EFX04210.1 - 0.0019 18.5 2.2 0.0019 18.5 2.2 2.3 2 0 0 2 2 2 1 Syntaxin-like protein Mu-like_Pro PF10123.9 EFX04210.1 - 0.0072 15.9 7.1 0.017 14.7 7.1 1.6 1 0 0 1 1 1 1 Mu-like prophage I protein ABC_tran_CTD PF16326.5 EFX04210.1 - 0.014 15.6 3.1 0.014 15.6 3.1 3.1 2 1 0 2 2 1 0 ABC transporter C-terminal domain DUF2373 PF10180.9 EFX04210.1 - 0.072 13.0 2.7 0.17 11.8 2.7 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) LPP PF04728.13 EFX04210.1 - 0.18 12.2 0.1 0.18 12.2 0.1 2.9 4 0 0 4 4 3 0 Lipoprotein leucine-zipper Snapin_Pallidin PF14712.6 EFX04210.1 - 0.33 11.4 4.4 1.5 9.2 0.2 2.6 2 0 0 2 2 2 0 Snapin/Pallidin Sec5 PF15469.6 EFX04210.1 - 1.1 9.0 7.4 0.11 12.3 1.6 2.0 2 0 0 2 2 2 0 Exocyst complex component Sec5 Cep57_MT_bd PF06657.13 EFX04210.1 - 2.7 8.5 6.6 1.5 9.4 1.2 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4140 PF13600.6 EFX04210.1 - 3.1 8.3 8.5 2.1 8.8 0.6 3.4 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) TssO PF17561.2 EFX04210.1 - 5.6 7.1 10.6 9.4 6.3 1.3 3.6 3 1 0 3 3 3 0 Type VI secretion system, TssO Nnf1 PF03980.14 EFX04210.1 - 5.9 7.3 11.6 1.3 9.4 5.8 2.8 2 1 1 3 3 3 0 Nnf1 CorA PF01544.18 EFX04211.1 - 3.4e-06 26.6 0.1 5.7e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein YqgC PF17430.2 EFX04212.1 - 0.022 14.8 1.9 0.21 11.7 2.3 2.4 2 0 0 2 2 2 0 Uncharacterized YqgC-like PolyA_pol PF01743.20 EFX04213.1 - 1.5e-27 96.5 0.1 4.9e-27 94.9 0.0 1.9 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EFX04213.1 - 1.2e-08 34.6 0.0 2.7e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A HVSL PF09749.9 EFX04214.1 - 2.4e-77 259.7 0.0 2.8e-77 259.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein Baculo_PEP_C PF04513.12 EFX04215.1 - 0.0029 17.6 5.8 0.09 12.8 2.5 2.3 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Adaptin_N PF01602.20 EFX04216.1 - 2.6e-123 412.4 7.4 3.1e-123 412.1 7.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EFX04216.1 - 2.4e-45 153.3 0.0 6.9e-45 151.9 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EFX04216.1 - 1.1e-15 57.9 0.0 2.1e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cas_Cas2CT1978 PF09707.10 EFX04216.1 - 0.45 10.6 1.4 3.5 7.8 0.1 2.9 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) Aminotran_4 PF01063.19 EFX04217.1 - 2.9e-20 73.1 0.0 5.9e-19 68.8 0.0 2.1 1 1 0 1 1 1 1 Amino-transferase class IV Phage_tail_APC PF16778.5 EFX04217.1 - 0.066 13.1 0.7 3.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone protein AIM24 PF01987.17 EFX04218.1 - 3e-50 170.8 0.0 3.7e-50 170.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Adaptin_binding PF10199.9 EFX04221.1 - 1.7e-11 44.8 0.1 4.6e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 AlaDh_PNT_N PF05222.15 EFX04222.1 - 9.5e-29 100.4 0.0 1.4e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EFX04222.1 - 7.5e-05 22.1 0.1 0.00046 19.6 0.1 2.0 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Abhydrolase_1 PF00561.20 EFX04223.1 - 5.5e-23 81.9 0.1 4.9e-22 78.8 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX04223.1 - 2e-22 79.7 0.0 2.6e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFX04223.1 - 3.5e-20 73.6 7.4 4.3e-20 73.3 7.4 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EFX04223.1 - 1e-08 35.6 0.0 1.8e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EFX04223.1 - 2.7e-05 23.9 0.1 3.5e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 EFX04223.1 - 3.4e-05 22.7 0.0 4.3e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_2 PF02230.16 EFX04223.1 - 0.0032 17.3 0.0 0.054 13.3 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Ser_hydrolase PF06821.13 EFX04223.1 - 0.0071 16.2 0.1 0.016 15.1 0.1 1.7 1 1 0 1 1 1 1 Serine hydrolase Abhydrolase_5 PF12695.7 EFX04223.1 - 0.0097 15.7 0.0 0.028 14.2 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EFX04223.1 - 0.043 13.4 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Peptidase_S28 PF05577.12 EFX04223.1 - 0.051 12.4 0.0 0.077 11.8 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 EFX04223.1 - 0.052 12.2 0.0 0.079 11.6 0.0 1.2 1 0 0 1 1 1 0 PS-10 peptidase S37 FSH1 PF03959.13 EFX04223.1 - 0.079 12.6 0.0 0.36 10.5 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 EFX04223.1 - 0.093 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.14 EFX04223.1 - 0.25 10.8 0.1 18 4.7 0.0 2.1 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Pkinase PF00069.25 EFX04224.1 - 2.4e-67 227.1 0.0 3e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04224.1 - 4.4e-32 111.4 0.0 5.5e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFX04224.1 - 7e-06 25.5 0.1 2.3e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFX04224.1 - 1.4e-05 24.2 0.1 2e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFX04224.1 - 0.00054 20.0 0.0 0.0016 18.4 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFX04224.1 - 0.0029 17.0 0.0 0.05 12.9 0.0 2.1 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 EFX04224.1 - 0.022 14.4 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EFX04224.1 - 0.026 14.2 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ApoO PF09769.9 EFX04225.1 - 5.8e-40 136.3 2.1 4.6e-38 130.1 0.0 2.8 3 0 0 3 3 3 2 Apolipoprotein O p450 PF00067.22 EFX04226.1 - 7.5e-63 212.9 0.0 9.4e-63 212.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 EFX04227.1 - 2.9e-96 323.1 18.0 3.3e-96 322.9 18.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04227.1 - 7.8e-34 117.1 23.7 7.8e-34 117.1 23.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Abhydrolase_1 PF00561.20 EFX04228.1 - 1.7e-18 67.2 0.0 1.4e-17 64.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX04228.1 - 5.5e-16 59.8 1.0 9.6e-16 59.0 1.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX04228.1 - 3.5e-10 39.6 0.0 2.5e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EFX04228.1 - 0.0064 16.3 0.0 0.047 13.5 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EFX04228.1 - 0.031 14.4 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.18 EFX04228.1 - 0.075 12.6 0.0 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family GTP_EFTU PF00009.27 EFX04229.1 - 2.9e-33 115.1 2.0 1e-31 110.0 2.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFX04229.1 - 6.6e-24 84.1 0.0 1.4e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EFX04229.1 - 6.2e-10 39.2 0.0 1.3e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 EFX04229.1 - 1.1e-05 25.1 0.0 2.2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region RsgA_GTPase PF03193.16 EFX04229.1 - 3.3e-05 23.8 0.6 0.00092 19.1 0.1 2.3 1 1 1 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFX04229.1 - 0.00016 21.2 0.0 0.00029 20.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 EFX04229.1 - 0.001 18.5 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EFX04229.1 - 0.007 16.1 0.1 0.021 14.6 0.1 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFX04229.1 - 0.008 15.6 0.1 0.022 14.2 0.1 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFX04229.1 - 0.054 13.7 0.0 0.096 12.9 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D2 PF03144.25 EFX04229.1 - 0.11 12.9 1.0 15 6.1 0.1 2.9 2 0 0 2 2 2 0 Elongation factor Tu domain 2 Sugar_tr PF00083.24 EFX04231.1 - 8.7e-122 407.2 16.8 1.6e-121 406.3 16.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04231.1 - 1.6e-32 112.9 55.3 6.7e-26 91.0 30.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex2_Pex12 PF04757.14 EFX04232.1 - 3.5e-50 170.7 1.4 4.4e-50 170.4 1.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EFX04232.1 - 0.00028 21.0 2.2 0.00047 20.2 2.2 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFX04232.1 - 0.017 14.9 3.1 0.028 14.2 3.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX04232.1 - 0.02 14.8 1.7 0.03 14.2 1.7 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX04232.1 - 0.074 13.1 1.3 0.14 12.2 1.3 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EFX04232.1 - 0.19 12.1 3.1 0.32 11.4 3.1 1.3 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 EFX04232.1 - 0.22 11.4 2.9 0.37 10.7 2.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ras PF00071.22 EFX04233.1 - 1.8e-16 60.2 0.0 3.5e-13 49.5 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFX04233.1 - 4.4e-05 23.7 0.0 0.00017 21.8 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX04233.1 - 0.0044 16.5 0.0 0.44 10.0 0.1 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family NACHT PF05729.12 EFX04233.1 - 0.012 15.5 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EFX04233.1 - 0.025 15.0 0.0 0.032 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFX04233.1 - 0.037 13.8 0.1 0.058 13.1 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EFX04233.1 - 0.052 12.7 0.0 0.076 12.2 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_24 PF13479.6 EFX04233.1 - 0.067 12.9 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFX04233.1 - 0.082 12.8 0.0 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 EFX04233.1 - 0.092 13.3 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 EFX04233.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Hpr_kinase_C PF07475.12 EFX04233.1 - 0.23 11.0 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain DUF1616 PF07760.11 EFX04234.1 - 0.1 11.9 0.0 0.11 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) GFA PF04828.14 EFX04235.1 - 1.8e-20 73.1 0.2 3.2e-20 72.2 0.2 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme FAD_binding_4 PF01565.23 EFX04236.1 - 1.5e-27 96.0 0.1 2.4e-27 95.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EFX04236.1 - 0.0048 16.6 0.1 0.0088 15.7 0.0 1.5 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain cNMPbd_u2 PF16643.5 EFX04237.1 - 3.1e-41 141.5 11.3 3.1e-41 141.5 11.3 2.0 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EFX04237.1 - 4.5e-32 110.0 0.0 6.2e-17 61.4 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain FMN_red PF03358.15 EFX04237.1 - 3.4e-27 95.1 0.1 9.3e-27 93.7 0.1 1.7 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFX04237.1 - 6.7e-07 29.2 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin-like fold LRR_6 PF13516.6 EFX04237.1 - 9.2e-06 25.3 2.8 0.24 11.5 0.0 5.4 6 0 0 6 6 6 2 Leucine Rich repeat F-box-like PF12937.7 EFX04237.1 - 2.2e-05 24.2 0.5 7.1e-05 22.6 0.5 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX04237.1 - 0.0011 18.8 3.0 0.0013 18.6 0.6 2.4 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.33 EFX04237.1 - 0.0014 18.9 0.2 73 4.5 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 EFX04237.1 - 0.054 13.9 3.8 9 6.9 0.1 4.5 4 1 2 6 6 6 0 Leucine Rich repeats (2 copies) WD40 PF00400.32 EFX04238.1 - 1.9e-22 79.1 3.9 1.6e-06 28.7 0.1 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat NLE PF08154.12 EFX04238.1 - 9.6e-15 54.9 0.1 1.8e-14 54.0 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 EFX04238.1 - 0.0079 16.5 0.0 2 8.8 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX04238.1 - 0.095 11.3 1.2 9.5 4.7 0.1 2.9 3 1 0 4 4 4 0 Nucleoporin Nup120/160 Asn_synthase PF00733.21 EFX04239.1 - 4.4e-91 306.2 0.1 2.3e-53 182.1 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EFX04239.1 - 4.8e-37 126.6 0.0 7.5e-37 126.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFX04239.1 - 4.8e-28 98.0 0.0 8.4e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EFX04239.1 - 2.5e-05 23.8 0.0 5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EFX04239.1 - 0.0052 15.9 0.0 0.017 14.3 0.0 1.7 2 0 0 2 2 2 1 NAD synthase Fungal_trans PF04082.18 EFX04240.1 - 3.5e-36 124.6 0.0 7.5e-36 123.5 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04240.1 - 0.00071 19.6 1.5 0.0012 18.9 1.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Catalase PF00199.19 EFX04241.1 - 2.8e-24 86.0 0.0 3.8e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 Catalase RNA_pol_A_bac PF01000.26 EFX04242.1 - 5.7e-27 94.3 0.0 1.1e-26 93.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFX04242.1 - 9.6e-20 69.8 0.0 1.5e-19 69.2 0.0 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Abhydrolase_1 PF00561.20 EFX04243.1 - 7.3e-21 75.0 0.2 3.5e-16 59.6 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EFX04243.1 - 4e-15 55.8 0.0 9.2e-15 54.6 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Pkinase PF00069.25 EFX04244.1 - 7.7e-24 84.5 0.0 2.9e-23 82.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04244.1 - 3.9e-15 55.8 0.0 6e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set PF05790.15 EFX04244.1 - 0.11 12.8 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin C2-set domain Cupin_2 PF07883.11 EFX04245.1 - 1.7e-08 34.0 0.1 0.00017 21.2 0.0 2.3 2 0 0 2 2 2 2 Cupin domain NAD_binding_8 PF13450.6 EFX04245.1 - 8.5e-06 25.9 0.1 2.3e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Cupin_1 PF00190.22 EFX04245.1 - 4e-05 23.3 0.0 7.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Cupin HI0933_like PF03486.14 EFX04245.1 - 0.00013 20.8 0.3 0.00062 18.6 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EFX04245.1 - 0.00024 20.4 0.0 0.0027 17.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX04245.1 - 0.00053 19.7 0.0 0.0036 16.9 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX04245.1 - 0.005 16.0 0.3 0.0089 15.1 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain GMC_oxred_N PF00732.19 EFX04245.1 - 0.044 13.2 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Pyr_redox PF00070.27 EFX04245.1 - 0.056 14.0 0.0 0.37 11.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX04245.1 - 0.057 12.3 0.1 0.082 11.7 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 EFX04245.1 - 0.073 12.4 0.2 0.27 10.5 0.2 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 EFX04245.1 - 0.14 11.4 0.2 0.22 10.7 0.2 1.2 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EFX04245.1 - 0.19 10.7 0.2 0.27 10.3 0.2 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Arf PF00025.21 EFX04246.1 - 5.3e-40 136.7 0.1 1.3e-25 89.8 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 EFX04246.1 - 2.4e-11 43.4 0.0 6.8e-06 25.5 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFX04246.1 - 5.8e-08 33.0 0.0 1.6e-07 31.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFX04246.1 - 9.2e-08 31.9 0.0 0.0045 16.6 0.0 2.2 2 0 0 2 2 2 2 Ras family Gtr1_RagA PF04670.12 EFX04246.1 - 2.9e-07 30.1 0.0 3.1e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFX04246.1 - 3.1e-06 26.7 0.0 0.00018 21.0 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFX04246.1 - 0.0013 18.3 0.0 0.0054 16.3 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFX04246.1 - 0.015 15.4 0.0 0.034 14.2 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rif1_N PF12231.8 EFX04247.1 - 2e-130 435.1 0.0 3.5e-130 434.4 0.0 1.4 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Serglycin PF04360.12 EFX04247.1 - 0.56 10.1 9.5 0.67 9.9 0.6 3.4 3 0 0 3 3 3 0 Serglycin Pkinase PF00069.25 EFX04248.1 - 1.8e-23 83.3 0.0 2.9e-14 53.1 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04248.1 - 8.1e-17 61.4 0.0 9.1e-08 31.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFX04248.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RCC1 PF00415.18 EFX04249.1 - 1.3e-19 70.5 0.7 1.7e-05 25.3 0.1 5.0 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFX04249.1 - 1.3e-12 47.9 0.0 3.1e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 EFX04249.1 - 2.1e-08 33.7 7.6 4.1e-07 29.6 0.9 3.7 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 EFX04249.1 - 3.7e-08 33.7 0.1 9.2e-08 32.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFX04249.1 - 1.4e-05 25.5 0.1 3.3e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX04249.1 - 3.9e-05 23.7 0.1 0.66 10.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat DUF2201_N PF13203.6 EFX04249.1 - 0.0058 16.3 3.1 0.0058 16.3 3.1 3.3 4 0 0 4 4 4 1 Putative metallopeptidase domain DUF2645 PF10840.8 EFX04249.1 - 0.26 12.0 0.0 0.54 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2645) GRP PF07172.11 EFX04249.1 - 0.3 11.8 37.6 1.9 9.2 8.6 4.2 4 0 0 4 4 4 0 Glycine rich protein family MFS_MOT1 PF16983.5 EFX04251.1 - 8.3e-60 200.0 39.8 9.8e-35 119.3 12.3 3.2 4 0 0 4 4 4 2 Molybdate transporter of MFS superfamily AAA PF00004.29 EFX04252.1 - 8e-12 45.7 0.2 8.7e-11 42.4 0.2 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX04252.1 - 0.019 15.3 0.0 0.068 13.5 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFX04252.1 - 0.021 15.1 0.0 0.055 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFX04252.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Striatin PF08232.12 EFX04252.1 - 0.16 12.6 6.6 0.35 11.5 4.4 2.6 2 0 0 2 2 2 0 Striatin family CCDC53 PF10152.9 EFX04252.1 - 4.2 7.8 6.9 2.7 8.4 4.5 1.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex PEGSRP PF07623.11 EFX04253.1 - 3.9 7.4 5.5 14 5.6 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1584) Trp_halogenase PF04820.14 EFX04254.1 - 6.3e-27 94.5 0.1 7.5e-13 48.1 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase Methyltransf_2 PF00891.18 EFX04254.1 - 2.7e-18 66.1 0.0 5.6e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase domain FAD_binding_3 PF01494.19 EFX04254.1 - 1.6e-14 53.9 0.0 2.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFX04254.1 - 0.00046 20.4 0.7 0.0037 17.5 0.3 2.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX04254.1 - 0.0031 16.8 0.0 0.0061 15.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX04254.1 - 0.015 14.7 0.5 0.027 13.8 0.5 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX04254.1 - 0.017 14.3 0.3 0.031 13.3 0.3 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 EFX04254.1 - 0.039 13.1 0.1 0.063 12.4 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 EFX04254.1 - 0.079 11.7 0.2 0.13 10.9 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein Pkinase PF00069.25 EFX04255.1 - 3.2e-43 148.0 0.0 1.3e-40 139.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04255.1 - 5.6e-13 48.8 0.0 5.6e-11 42.2 0.0 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EFX04255.1 - 5.7e-05 23.2 0.2 0.01 15.8 0.0 3.0 2 2 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFX04255.1 - 0.0014 17.5 0.0 0.0025 16.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFX04255.1 - 0.019 14.3 0.1 0.28 10.5 0.1 2.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFX04255.1 - 0.022 14.1 0.0 0.066 12.5 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Peptidase_S8 PF00082.22 EFX04256.1 - 8.6e-16 58.0 3.0 3e-15 56.3 0.5 2.2 2 0 0 2 2 2 1 Subtilase family Ank_2 PF12796.7 EFX04256.1 - 0.00058 20.4 0.1 0.15 12.7 0.0 3.3 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) NAD_binding_10 PF13460.6 EFX04257.1 - 4.9e-23 82.0 1.4 7.2e-23 81.4 1.4 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFX04257.1 - 0.0019 17.7 0.1 0.0046 16.5 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ANAPC4 PF12896.7 EFX04258.1 - 1.6e-58 197.6 1.6 1.8e-58 197.4 0.3 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EFX04258.1 - 1.3e-12 47.8 0.0 3.1e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_24 PF13578.6 EFX04259.1 - 1.3e-12 48.7 0.0 2.5e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain AAA_16 PF13191.6 EFX04261.1 - 0.091 13.1 0.2 0.15 12.4 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain Malic_M PF03949.15 EFX04262.1 - 3.8e-82 275.4 0.0 5.1e-82 275.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFX04262.1 - 8.5e-61 204.9 0.0 1.2e-60 204.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Fer2_3 PF13085.6 EFX04263.1 - 6e-31 106.7 0.0 1.2e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EFX04263.1 - 4.2e-08 33.6 5.5 4.2e-08 33.6 5.5 2.2 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EFX04263.1 - 5.3e-08 33.2 6.8 5.3e-08 33.2 6.8 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFX04263.1 - 9.1e-07 28.9 1.7 9.1e-07 28.9 1.7 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EFX04263.1 - 0.00035 20.5 1.8 0.0042 17.0 0.4 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 EFX04263.1 - 0.013 16.1 3.9 0.013 16.1 3.9 2.3 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFX04263.1 - 1.3 9.3 11.5 4 7.7 8.6 2.8 2 1 2 4 4 4 0 4Fe-4S dicluster domain RNase_PH PF01138.21 EFX04264.1 - 6.8e-22 78.4 0.0 1.3e-21 77.5 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFX04264.1 - 4.4e-08 33.1 0.0 2.6e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 DNA_ligase_OB PF03120.16 EFX04264.1 - 0.0087 15.9 0.2 0.12 12.3 0.0 2.3 2 0 0 2 2 2 1 NAD-dependent DNA ligase OB-fold domain Arabino_trans_C PF14896.6 EFX04265.1 - 0.063 12.3 0.0 0.096 11.7 0.0 1.1 1 0 0 1 1 1 0 EmbC C-terminal domain Paramyxo_C PF01692.18 EFX04265.1 - 0.12 11.8 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C IlvN PF07991.12 EFX04266.1 - 5.8e-46 156.1 0.0 9.7e-46 155.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EFX04266.1 - 1.1e-40 139.3 0.0 1.7e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 EFX04266.1 - 0.029 15.0 0.2 0.086 13.4 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent KH_1 PF00013.29 EFX04267.1 - 1.8e-43 146.2 7.5 4.1e-18 65.0 0.5 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EFX04267.1 - 1.3e-13 50.6 3.3 0.0024 17.7 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EFX04267.1 - 6.7e-07 29.1 1.1 0.29 11.0 0.0 3.3 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EFX04267.1 - 1.1e-06 28.5 0.0 0.0052 16.8 0.0 3.2 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 EFX04267.1 - 0.00019 21.4 8.7 0.42 10.7 0.3 3.4 3 0 0 3 3 3 3 NusA-like KH domain MR_MLE_N PF02746.16 EFX04267.1 - 0.13 12.5 0.1 8.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain ketoacyl-synt PF00109.26 EFX04268.1 - 6.4e-67 225.8 0.2 1.4e-64 218.1 0.2 2.6 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFX04268.1 - 1.3e-38 133.3 0.0 2.7e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFX04268.1 - 2.6e-32 111.3 0.4 1e-31 109.4 0.4 2.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFX04268.1 - 1.4e-15 57.4 0.3 4.1e-15 55.9 0.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site SAT PF16073.5 EFX04268.1 - 3.6e-09 36.7 5.5 4.1e-08 33.3 0.1 3.4 3 2 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis KAsynt_C_assoc PF16197.5 EFX04268.1 - 1.4e-06 28.7 0.0 3.6e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EFX04268.1 - 6.7e-06 25.6 0.2 1.3e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain BRK PF07533.16 EFX04268.1 - 0.059 13.0 0.0 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 BRK domain ACP_syn_III PF08545.10 EFX04268.1 - 0.22 11.4 3.6 0.59 10.0 3.6 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III AA_permease_2 PF13520.6 EFX04269.1 - 2.9e-63 214.2 51.6 3.6e-63 213.9 51.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX04269.1 - 2.2e-19 69.4 44.0 2.9e-19 69.0 44.0 1.1 1 0 0 1 1 1 1 Amino acid permease Arginase PF00491.21 EFX04272.1 - 7.3e-91 304.5 0.0 9.8e-91 304.1 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EFX04272.1 - 0.091 13.0 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 UPF0489 domain Metallophos PF00149.28 EFX04273.1 - 5.5e-13 49.9 1.2 8.8e-13 49.2 1.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFX04273.1 - 7.7e-05 22.9 0.2 0.00049 20.3 0.2 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CoaE PF01121.20 EFX04274.1 - 7.1e-41 139.8 0.0 1.3e-40 139.0 0.0 1.4 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EFX04274.1 - 0.12 12.9 0.2 0.44 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Hemerythrin PF01814.23 EFX04275.1 - 5e-07 30.4 0.1 6.9e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Exo_endo_phos PF03372.23 EFX04276.1 - 1.1e-11 44.7 0.5 1.2e-10 41.3 0.1 2.4 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family CMD PF02627.20 EFX04277.1 - 2.7e-08 33.7 2.0 8e-07 29.0 0.5 2.5 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family DUF3253 PF11625.8 EFX04277.1 - 0.078 13.2 0.8 0.15 12.3 0.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3253) Sybindin PF04099.12 EFX04278.1 - 2.3e-49 167.0 0.0 3.3e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFX04278.1 - 3.1e-07 30.6 0.0 4.7e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region MFS_1 PF07690.16 EFX04279.1 - 1.8e-17 63.4 17.0 2.3e-17 62.9 17.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CBM_2 PF00553.19 EFX04279.1 - 0.037 14.3 0.4 0.082 13.2 0.4 1.5 1 0 0 1 1 1 0 Cellulose binding domain IU_nuc_hydro PF01156.19 EFX04280.1 - 2.4e-54 185.0 0.0 5.9e-54 183.7 0.0 1.6 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Colicin_M PF14859.6 EFX04280.1 - 0.17 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Colicin M CLTH PF10607.9 EFX04282.1 - 9.2e-32 110.0 0.0 1.3e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EFX04282.1 - 4.2e-29 101.1 0.2 6.6e-29 100.5 0.2 1.3 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EFX04282.1 - 4.4e-06 26.5 0.2 1.3e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 LisH CG-1 PF03859.16 EFX04282.1 - 0.057 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 CG-1 domain DUF2428 PF10350.9 EFX04283.1 - 6.4e-55 186.3 1.8 1.5e-54 185.1 1.8 1.7 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EFX04283.1 - 1.5 9.3 25.0 5.5 7.5 0.0 7.6 7 0 0 7 7 7 0 HEAT repeat Transp_cyt_pur PF02133.15 EFX04285.1 - 1.4e-90 304.2 36.8 1.8e-68 231.4 22.0 2.0 2 0 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin Aconitase PF00330.20 EFX04286.1 - 1.4e-158 528.7 0.0 1.8e-158 528.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFX04286.1 - 6.2e-37 126.9 0.0 1.1e-36 126.1 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Fungal_trans_2 PF11951.8 EFX04287.1 - 6.1e-31 107.6 0.0 7.9e-31 107.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04287.1 - 5.7e-07 29.5 10.6 1.3e-06 28.4 10.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF775 PF05603.12 EFX04288.1 - 2.1e-51 174.3 0.0 3.5e-51 173.6 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF775) PhyH PF05721.13 EFX04289.1 - 2.2e-07 31.4 0.0 4.8e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) ABC_tran PF00005.27 EFX04290.1 - 1e-46 158.8 0.1 4e-23 82.4 0.0 3.5 2 1 0 2 2 2 2 ABC transporter 4HB PF17947.1 EFX04290.1 - 2.4e-29 101.2 0.1 7.8e-29 99.6 0.1 2.0 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 EFX04290.1 - 4.3e-17 62.9 0.0 0.002 18.0 0.0 5.2 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX04290.1 - 1.8e-16 60.3 0.8 0.00012 21.6 0.1 4.2 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFX04290.1 - 8.2e-09 35.1 0.1 0.0043 16.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFX04290.1 - 5.8e-08 32.8 0.2 0.0011 18.9 0.0 3.0 2 1 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EFX04290.1 - 8.8e-08 32.9 7.2 0.0025 18.3 0.0 3.2 4 0 0 4 4 2 2 AAA domain AAA_28 PF13521.6 EFX04290.1 - 3.2e-07 30.7 0.0 0.012 15.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFX04290.1 - 7e-07 29.6 0.0 0.008 16.5 0.0 3.4 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EFX04290.1 - 1.4e-06 28.4 0.0 0.0087 16.1 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase MeaB PF03308.16 EFX04290.1 - 3.1e-06 26.4 0.2 0.085 11.8 0.0 3.1 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EFX04290.1 - 4.5e-06 27.2 0.0 0.065 13.8 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.6 EFX04290.1 - 6.5e-06 26.1 0.3 0.032 14.0 0.1 3.0 2 1 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 EFX04290.1 - 1e-05 25.7 0.0 0.0018 18.4 0.0 2.8 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 EFX04290.1 - 1.4e-05 25.6 1.1 0.17 12.2 0.0 3.9 5 0 0 5 5 3 2 AAA ATPase domain AAA PF00004.29 EFX04290.1 - 2.2e-05 24.9 0.0 0.3 11.5 0.0 4.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFX04290.1 - 2.7e-05 24.4 0.0 0.48 10.6 0.0 3.0 2 0 0 2 2 2 2 AAA domain ParcG PF10274.9 EFX04290.1 - 4.8e-05 23.6 0.4 0.36 10.9 0.0 3.0 1 1 2 3 3 3 2 Parkin co-regulated protein PduV-EutP PF10662.9 EFX04290.1 - 5.9e-05 22.8 0.0 0.044 13.5 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EFX04290.1 - 0.0001 22.7 0.0 0.85 10.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_27 PF13514.6 EFX04290.1 - 0.00012 21.7 0.0 0.11 12.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EFX04290.1 - 0.00018 21.7 0.0 0.12 12.5 0.0 3.3 3 0 0 3 3 2 1 Helicase HerA, central domain NACHT PF05729.12 EFX04290.1 - 0.00024 21.1 0.0 0.17 11.8 0.0 2.7 2 0 0 2 2 2 1 NACHT domain G-alpha PF00503.20 EFX04290.1 - 0.00025 20.3 0.0 0.6 9.2 0.0 2.5 2 0 0 2 2 2 2 G-protein alpha subunit AAA_24 PF13479.6 EFX04290.1 - 0.0004 20.2 0.1 1.7 8.4 0.0 3.4 3 1 0 3 3 3 2 AAA domain Rad17 PF03215.15 EFX04290.1 - 0.00082 19.3 0.0 1.8 8.5 0.0 2.8 3 0 0 3 3 2 1 Rad17 P-loop domain AAA_14 PF13173.6 EFX04290.1 - 0.0018 18.3 0.0 3.3 7.8 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EFX04290.1 - 0.0018 18.0 0.0 3.5 7.3 0.0 3.4 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.17 EFX04290.1 - 0.0029 17.4 0.0 3.9 7.2 0.0 2.9 2 0 0 2 2 2 0 IstB-like ATP binding protein PRK PF00485.18 EFX04290.1 - 0.0035 17.1 0.0 0.34 10.6 0.0 2.8 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EFX04290.1 - 0.0047 16.1 0.5 0.19 10.9 0.0 2.6 3 0 0 3 3 3 1 NB-ARC domain SbcCD_C PF13558.6 EFX04290.1 - 0.0054 16.9 0.0 1.1 9.5 0.0 3.2 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit cobW PF02492.19 EFX04290.1 - 0.0056 16.3 0.0 4 7.0 0.0 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EFX04290.1 - 0.006 16.4 0.0 5 6.8 0.0 3.0 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EFX04290.1 - 0.01 15.7 0.0 0.8 9.5 0.0 2.6 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ATPase_2 PF01637.18 EFX04290.1 - 0.01 15.8 0.1 1.9 8.4 0.0 3.1 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea Roc PF08477.13 EFX04290.1 - 0.014 15.6 0.0 9 6.5 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EFX04290.1 - 0.028 14.0 0.1 4.1 6.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Cytidylate_kin PF02224.18 EFX04290.1 - 0.034 13.9 0.0 8.8 6.0 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase Septin PF00735.18 EFX04290.1 - 0.035 13.4 0.4 4.5 6.5 0.0 2.7 3 0 0 3 3 2 0 Septin AAA_25 PF13481.6 EFX04290.1 - 0.035 13.7 0.0 2.8 7.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EFX04290.1 - 0.036 13.2 0.0 12 4.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EFX04290.1 - 0.05 12.6 0.0 5.4 6.0 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Ploopntkinase3 PF18751.1 EFX04290.1 - 0.057 13.3 0.1 8.8 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 NTPase_1 PF03266.15 EFX04290.1 - 0.06 13.3 0.1 13 5.7 0.1 2.6 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EFX04290.1 - 0.064 13.3 0.3 47 4.0 0.0 3.5 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP-synt_ab PF00006.25 EFX04290.1 - 0.065 12.9 0.2 12 5.5 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.21 EFX04290.1 - 0.094 12.1 0.0 8.2 5.7 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFX04290.1 - 0.13 12.3 0.0 32 4.5 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_13 PF13166.6 EFX04290.1 - 10 4.7 10.0 1.4 7.4 0.0 2.9 4 0 0 4 4 2 0 AAA domain LSM PF01423.22 EFX04291.1 - 2.8e-18 65.4 0.6 4.1e-18 64.8 0.6 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EFX04291.1 - 0.011 15.3 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 0 Hfq protein DUF1461 PF07314.11 EFX04291.1 - 0.051 13.5 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) YbbR PF07949.12 EFX04291.1 - 0.06 13.7 0.8 0.31 11.4 0.2 1.9 1 1 1 2 2 2 0 YbbR-like protein SKG6 PF08693.10 EFX04292.1 - 0.12 11.8 1.5 0.33 10.4 1.5 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LEA_6 PF10714.9 EFX04292.1 - 0.21 11.7 1.1 0.82 9.8 0.3 2.5 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 Nop14 PF04147.12 EFX04293.1 - 3.8 5.6 11.8 6.4 4.8 11.8 1.2 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EFX04293.1 - 7.1 6.6 9.8 19 5.3 9.8 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 EFX04293.1 - 9.5 5.9 6.1 20 4.9 6.1 1.5 1 0 0 1 1 1 0 FAM176 family AMP-binding PF00501.28 EFX04294.1 - 1.5e-90 303.8 0.0 2.3e-90 303.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX04294.1 - 0.014 16.4 0.3 0.045 14.7 0.3 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain CENP-K PF11802.8 EFX04295.1 - 2.4e-06 27.3 0.0 0.013 15.1 0.0 2.4 2 1 0 2 2 2 2 Centromere-associated protein K CDK5_activator PF03261.15 EFX04295.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF1018 PF06252.12 EFX04295.1 - 1.1 10.3 9.8 1.2 10.1 2.2 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1018) Cu_amine_oxid PF01179.20 EFX04296.1 - 1.6e-119 399.5 0.0 2.1e-119 399.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EFX04296.1 - 2.2e-06 27.3 0.6 4.4e-06 26.4 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1965) 2-Hacid_dh_C PF02826.19 EFX04298.1 - 1.2e-49 168.1 0.0 2e-49 167.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX04298.1 - 8.9e-16 57.8 0.0 1.2e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFX04298.1 - 0.00013 22.1 0.0 0.00046 20.4 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EFX04298.1 - 0.0057 16.0 0.1 0.36 10.1 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain SUN PF03856.13 EFX04299.1 - 2.4e-86 289.2 12.9 2.4e-86 289.2 12.9 1.6 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) Apt1 PF10351.9 EFX04299.1 - 0.035 13.0 8.8 0.042 12.7 8.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EFX04299.1 - 0.52 8.8 14.3 0.66 8.5 14.3 1.1 1 0 0 1 1 1 0 Macoilin family adh_short_C2 PF13561.6 EFX04300.1 - 3.5e-51 174.0 0.0 4.4e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX04300.1 - 6.9e-43 146.4 0.0 8.4e-43 146.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX04300.1 - 1.7e-07 31.3 0.1 2.6e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 KR domain DFP PF04127.15 EFX04300.1 - 0.07 12.9 5.7 0.27 11.0 5.7 1.8 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein TetR_C_33 PF13305.6 EFX04300.1 - 0.22 12.3 0.1 0.22 12.3 0.1 2.2 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Glyco_hydro_2_C PF02836.17 EFX04301.1 - 7.8e-103 343.7 0.0 1e-102 343.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 EFX04301.1 - 1.6e-60 204.8 0.0 3e-60 203.8 0.0 1.5 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 EFX04301.1 - 3.4e-44 150.7 0.9 4.1e-43 147.2 0.3 2.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EFX04301.1 - 4.9e-16 59.4 0.2 1.1e-15 58.3 0.2 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 DUF4981 PF16353.5 EFX04301.1 - 1.5e-09 38.2 0.1 2.7e-08 34.2 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function(DUF4981) Rieske PF00355.26 EFX04302.1 - 6.3e-15 54.9 0.0 1.2e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Ring_hydroxyl_A PF00848.19 EFX04302.1 - 0.32 10.9 2.6 0.5 10.3 0.4 2.0 1 1 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) Rod_cone_degen PF15201.6 EFX04304.1 - 0.26 11.4 13.6 36 4.5 0.1 4.9 1 1 4 5 5 5 0 Progressive rod-cone degeneration Acetyltransf_3 PF13302.7 EFX04305.1 - 2.4e-14 54.2 0.0 5.8e-14 52.9 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX04305.1 - 6.6e-06 26.4 0.0 1e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family CytadhesinP1 PF12378.8 EFX04305.1 - 0.052 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Trypsin-sensitive surface-exposed protein Acetyltransf_8 PF13523.6 EFX04305.1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain IMS PF00817.20 EFX04306.1 - 8.4e-37 126.5 0.0 1.6e-36 125.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EFX04306.1 - 3.6e-24 85.0 0.9 1.1e-23 83.4 0.7 2.0 2 0 0 2 2 2 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 EFX04306.1 - 3.1e-12 45.5 15.7 9.4e-09 34.4 1.3 3.6 3 0 0 3 3 3 2 Ubiquitin binding region IMS_C PF11799.8 EFX04306.1 - 8.7e-12 45.8 0.0 2.4e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 EFX04306.1 - 4.2e-06 27.1 0.0 1.3e-05 25.5 0.0 1.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFX04306.1 - 0.0012 19.1 0.0 0.0036 17.6 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFX04306.1 - 0.0031 17.8 0.0 0.0064 16.7 0.0 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 EFX04306.1 - 0.0031 17.4 0.0 0.012 15.5 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain DUF1805 PF08827.11 EFX04306.1 - 0.075 13.4 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) UPF0029 PF01205.19 EFX04307.1 - 2.7e-22 79.1 0.2 9.1e-22 77.4 0.0 2.0 3 0 0 3 3 3 1 Uncharacterized protein family UPF0029 tRNA-synt_1c PF00749.21 EFX04309.1 - 1.9e-97 326.0 0.0 2.6e-97 325.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFX04309.1 - 1.4e-29 103.2 0.0 4.4e-29 101.6 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain Sdh5 PF03937.16 EFX04310.1 - 4.7e-25 87.3 1.1 1.9e-24 85.4 1.0 1.9 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase Peptidase_M48 PF01435.18 EFX04311.1 - 5.7e-33 114.3 0.0 1.6e-32 112.9 0.0 1.8 1 0 0 1 1 1 1 Peptidase family M48 Glyco_hydro_16 PF00722.21 EFX04311.1 - 1e-05 25.1 1.1 2e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 zf-CCCH PF00642.24 EFX04312.1 - 6.9e-15 54.5 33.0 9.5e-07 28.6 0.4 5.5 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFX04312.1 - 1.3e-09 37.8 36.8 5.7e-05 23.0 2.5 5.4 5 0 0 5 5 5 3 Zinc finger domain Methyltransf_23 PF13489.6 EFX04312.1 - 5.6e-09 36.0 0.0 1.3e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Torus PF16131.5 EFX04312.1 - 2.1e-05 25.2 25.7 0.0024 18.5 0.7 5.3 1 1 4 5 5 5 3 Torus domain zf-CCCH_4 PF18044.1 EFX04312.1 - 0.0011 18.8 0.9 0.0011 18.8 0.9 5.2 5 0 0 5 5 5 2 CCCH-type zinc finger Methyltransf_25 PF13649.6 EFX04312.1 - 0.035 14.8 0.0 0.081 13.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain FAD_binding_4 PF01565.23 EFX04313.1 - 3.9e-24 85.0 0.7 6.9e-24 84.2 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain Dak1 PF02733.17 EFX04314.1 - 1.1e-99 333.3 6.2 1.5e-99 332.9 6.2 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EFX04314.1 - 1.8e-44 151.7 3.6 1.8e-44 151.7 3.6 2.1 2 0 0 2 2 2 1 DAK2 domain Pex24p PF06398.11 EFX04315.1 - 0.082 11.9 6.6 0.13 11.3 6.6 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin bZIP_1 PF00170.21 EFX04316.1 - 7.4e-08 32.4 7.7 2.2e-07 30.9 7.7 1.9 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFX04316.1 - 0.014 15.5 6.6 0.014 15.5 6.6 2.1 1 1 1 2 2 2 0 Basic region leucine zipper Prenyltransf PF01255.19 EFX04318.1 - 4.5e-79 265.1 0.0 8.6e-79 264.2 0.0 1.4 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase WD40 PF00400.32 EFX04319.1 - 1.5e-33 114.3 21.1 1.4e-08 35.2 1.5 7.3 7 1 0 7 7 7 5 WD domain, G-beta repeat PRP4 PF08799.11 EFX04319.1 - 2e-12 46.4 3.5 4.2e-12 45.4 3.5 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EFX04319.1 - 3.1e-11 43.4 0.1 0.089 13.1 0.1 6.1 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFX04319.1 - 0.032 13.6 0.0 4.1 6.6 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Nbas_N PF15492.6 EFX04319.1 - 0.034 13.5 0.0 1.8 7.8 0.0 2.5 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EFX04319.1 - 0.084 11.8 0.0 21 3.9 0.0 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SKIP_SNW PF02731.15 EFX04320.1 - 6.7e-69 230.6 4.0 6.7e-69 230.6 4.0 2.2 2 0 0 2 2 2 1 SKIP/SNW domain Serglycin PF04360.12 EFX04320.1 - 0.079 12.9 0.3 0.15 12.0 0.3 1.4 1 0 0 1 1 1 0 Serglycin PsbW PF07123.12 EFX04320.1 - 0.082 12.9 0.0 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) Gcn1_N PF12074.8 EFX04322.1 - 8.6e-119 397.0 2.6 5e-118 394.5 2.6 2.5 1 0 0 1 1 1 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 EFX04322.1 - 8e-29 97.2 41.2 0.012 15.8 0.1 21.4 25 0 0 25 25 22 9 HEAT repeat HEAT_EZ PF13513.6 EFX04322.1 - 2.8e-25 88.3 51.7 3.8e-07 30.5 0.0 18.7 15 3 7 22 22 19 7 HEAT-like repeat HEAT_2 PF13646.6 EFX04322.1 - 4.8e-24 84.6 60.3 3.7e-06 27.2 0.2 14.3 10 4 7 17 17 16 7 HEAT repeats Cnd1 PF12717.7 EFX04322.1 - 2.6e-16 60.1 3.2 0.23 11.5 0.4 9.6 6 3 1 9 9 9 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFX04322.1 - 2.3e-14 53.8 0.0 0.46 11.1 0.1 9.9 7 3 4 11 11 11 2 Vacuolar 14 Fab1-binding region ParcG PF10274.9 EFX04322.1 - 7e-12 45.8 4.3 0.00042 20.5 0.0 6.5 6 2 1 7 7 6 3 Parkin co-regulated protein Adaptin_N PF01602.20 EFX04322.1 - 3.3e-10 39.1 5.3 1.1e-05 24.2 2.1 6.6 4 3 2 6 6 6 1 Adaptin N terminal region CLASP_N PF12348.8 EFX04322.1 - 3.5e-10 39.8 0.0 0.016 14.8 0.0 6.7 4 2 2 6 6 6 2 CLASP N terminal UME PF08064.13 EFX04322.1 - 1.7e-07 31.0 3.3 0.054 13.4 0.1 8.3 8 1 1 9 9 8 1 UME (NUC010) domain MMS19_C PF12460.8 EFX04322.1 - 4.4e-05 22.8 16.2 0.23 10.5 0.4 7.2 5 2 1 6 6 6 2 RNAPII transcription regulator C-terminal TIP120 PF08623.10 EFX04322.1 - 5e-05 23.1 0.5 0.076 12.8 0.0 5.4 4 1 1 5 5 5 1 TATA-binding protein interacting (TIP20) TFCD_C PF12612.8 EFX04322.1 - 0.0034 17.3 1.7 0.055 13.3 0.1 3.4 2 1 1 3 3 3 1 Tubulin folding cofactor D C terminal Tti2 PF10521.9 EFX04322.1 - 0.0094 15.5 2.4 2.3 7.7 0.0 5.1 5 2 2 7 7 6 1 Tti2 family Pes-10 PF07149.11 EFX04322.1 - 0.023 13.8 0.3 0.047 12.8 0.3 1.4 1 0 0 1 1 1 0 Pes-10 Ipi1_N PF12333.8 EFX04322.1 - 0.23 12.1 2.5 1.1 9.9 0.1 3.6 4 0 0 4 4 1 0 Rix1 complex component involved in 60S ribosome maturation WASH-7_C PF14746.6 EFX04322.1 - 0.28 10.9 2.0 0.7 9.6 2.0 1.6 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal MnmE_helical PF12631.7 EFX04322.1 - 0.38 10.9 5.9 24 5.0 0.7 4.5 4 0 0 4 4 4 0 MnmE helical domain Urb2 PF10441.9 EFX04322.1 - 2.8 7.8 13.1 1.3 9.0 1.2 5.0 6 0 0 6 6 5 0 Urb2/Npa2 family TPR_20 PF14561.6 EFX04322.1 - 5.4 7.4 7.6 4 7.8 2.5 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Cut8 PF08559.10 EFX04323.1 - 4.6e-74 249.1 0.0 5.6e-74 248.8 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Thiolase_N PF00108.23 EFX04324.1 - 7.3e-72 241.8 3.5 7.3e-72 241.8 3.5 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFX04324.1 - 9.5e-46 154.4 0.2 1.7e-45 153.6 0.2 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFX04324.1 - 0.0012 18.4 4.2 0.005 16.4 1.3 2.6 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 EFX04324.1 - 0.058 13.6 0.0 0.2 11.9 0.0 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal SMC_ScpA PF02616.14 EFX04325.1 - 3.4e-05 23.9 2.9 3.7e-05 23.7 2.9 1.1 1 0 0 1 1 1 1 Segregation and condensation protein ScpA FlgN PF05130.12 EFX04325.1 - 0.0004 20.9 3.9 0.00056 20.4 3.9 1.2 1 0 0 1 1 1 1 FlgN protein DUF885 PF05960.11 EFX04325.1 - 0.00057 19.7 1.0 0.00066 19.5 1.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) Helo_like_N PF17111.5 EFX04325.1 - 0.0023 17.3 4.2 0.0052 16.2 0.4 2.1 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EFX04325.1 - 0.0059 16.8 5.2 0.014 15.6 2.3 2.0 1 1 1 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases FliJ PF02050.16 EFX04325.1 - 0.0075 16.5 2.0 0.025 14.8 2.1 1.8 2 0 0 2 2 2 1 Flagellar FliJ protein V-SNARE PF05008.15 EFX04325.1 - 0.0099 16.2 7.4 0.25 11.7 2.6 3.0 1 1 1 2 2 2 1 Vesicle transport v-SNARE protein N-terminus DUF16 PF01519.16 EFX04325.1 - 0.014 15.9 7.6 0.18 12.3 4.7 2.8 1 1 0 2 2 2 0 Protein of unknown function DUF16 Syntaxin PF00804.25 EFX04325.1 - 0.036 13.8 3.6 0.079 12.6 3.6 1.6 1 1 0 1 1 1 0 Syntaxin Prefoldin_2 PF01920.20 EFX04325.1 - 0.042 13.8 8.9 0.044 13.7 2.8 2.1 1 1 1 2 2 2 0 Prefoldin subunit Uso1_p115_C PF04871.13 EFX04325.1 - 0.065 13.6 4.8 0.074 13.4 3.9 1.5 2 0 0 2 2 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CbiK PF06180.11 EFX04325.1 - 0.079 12.3 0.2 1.4 8.1 0.0 2.2 1 1 1 2 2 2 0 Cobalt chelatase (CbiK) V_ATPase_I PF01496.19 EFX04325.1 - 0.11 10.4 3.5 0.13 10.2 3.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 EFX04325.1 - 0.12 12.5 4.1 0.59 10.2 0.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Turandot PF07240.11 EFX04325.1 - 0.12 12.4 0.5 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot Osmo_CC PF08946.10 EFX04325.1 - 0.12 12.7 5.3 0.12 12.6 0.3 3.0 3 1 0 3 3 3 0 Osmosensory transporter coiled coil Allexi_40kDa PF05549.11 EFX04325.1 - 0.13 11.7 2.0 0.23 11.0 1.4 1.5 1 1 1 2 2 2 0 Allexivirus 40kDa protein H-kinase_dim PF02895.14 EFX04325.1 - 0.14 12.6 2.9 1.1 9.8 0.3 2.8 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain PRESAN PF09687.10 EFX04325.1 - 0.16 12.5 4.8 2 9.0 3.9 2.6 2 1 0 2 2 2 0 Plasmodium RESA N-terminal Phasin PF05597.11 EFX04325.1 - 0.17 11.9 3.7 0.41 10.7 1.7 2.0 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Tho2 PF11262.8 EFX04325.1 - 0.18 11.0 3.7 0.2 10.9 2.9 1.4 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF948 PF06103.11 EFX04325.1 - 0.19 12.0 1.5 2.3 8.6 0.5 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) MetOD2 PF18548.1 EFX04325.1 - 0.22 11.7 3.6 0.42 10.7 0.5 2.2 2 1 0 2 2 2 0 Metanogen output domain 2 Baculo_PEP_C PF04513.12 EFX04325.1 - 0.3 11.1 5.4 8.5 6.4 5.4 2.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2203 PF09969.9 EFX04325.1 - 0.34 11.7 2.7 4.7 7.9 1.8 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2852 PF11014.8 EFX04325.1 - 0.34 11.1 2.4 4.4 7.5 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) TMF_TATA_bd PF12325.8 EFX04325.1 - 0.39 10.9 5.6 0.35 11.1 4.1 1.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Syntaxin-6_N PF09177.11 EFX04325.1 - 0.53 10.9 6.3 0.41 11.2 1.2 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Rx_N PF18052.1 EFX04325.1 - 0.56 10.5 4.1 0.34 11.2 1.2 1.9 1 1 1 2 2 2 0 Rx N-terminal domain DUF5446 PF17522.2 EFX04325.1 - 8.1 6.7 9.0 6.4 7.0 0.7 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5446) Zn_clus PF00172.18 EFX04326.1 - 3.6e-05 23.8 9.4 6e-05 23.1 9.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FKBP_C PF00254.28 EFX04327.1 - 4.5e-25 87.8 0.1 5.3e-25 87.6 0.1 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase VWA_2 PF13519.6 EFX04328.1 - 5.4e-23 81.7 0.2 1.6e-22 80.2 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 EFX04328.1 - 3.6e-08 33.4 0.0 6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 EFX04328.1 - 1.7e-05 25.1 0.2 2.5e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 EFX04328.1 - 0.006 16.4 1.1 0.022 14.6 1.1 2.0 1 0 0 1 1 1 1 Ubiquitin interaction motif zf-C2H2_4 PF13894.6 EFX04329.1 - 0.026 15.3 1.6 11 7.2 0.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFX04329.1 - 0.04 14.4 6.7 0.42 11.2 0.4 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type BRD4_CDT PF17105.5 EFX04329.1 - 1.3 8.6 5.3 2.6 7.7 5.3 1.4 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 p450 PF00067.22 EFX04330.1 - 1.5e-46 159.1 0.0 1.8e-46 158.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cellulase PF00150.18 EFX04331.1 - 4.6e-17 62.4 4.2 6.2e-17 61.9 4.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) NAD_binding_4 PF07993.12 EFX04332.1 - 4.6e-29 101.4 0.0 8e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EFX04332.1 - 3.6e-24 85.1 0.0 6.9e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EFX04332.1 - 8e-12 45.1 0.0 1.5e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EFX04332.1 - 0.00016 21.9 0.0 0.00034 20.9 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 EFX04332.1 - 0.0014 18.1 0.0 0.0088 15.5 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EFX04332.1 - 0.07 13.0 0.5 0.4 10.6 0.2 2.4 2 1 0 2 2 2 0 KR domain Polysacc_synt_2 PF02719.15 EFX04332.1 - 0.13 11.3 0.0 0.41 9.7 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Peptidase_S64 PF08192.11 EFX04333.1 - 6e-05 21.8 0.0 0.0041 15.7 0.0 2.0 2 0 0 2 2 2 2 Peptidase family S64 Trypsin_2 PF13365.6 EFX04333.1 - 0.026 15.4 0.0 0.53 11.2 0.0 2.4 1 1 0 1 1 1 0 Trypsin-like peptidase domain Peptidase_S3 PF00944.19 EFX04333.1 - 0.17 11.7 0.1 0.32 10.8 0.1 1.4 1 0 0 1 1 1 0 Alphavirus core protein SAP30_Sin3_bdg PF13867.6 EFX04334.1 - 2e-06 28.0 0.3 7.9e-06 26.1 0.1 2.1 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Type_III_YscG PF09477.10 EFX04334.1 - 0.096 12.8 0.3 3.1 7.9 0.1 2.3 1 1 1 2 2 2 0 Bacterial type II secretion system chaperone protein (type_III_yscG) Fungal_trans PF04082.18 EFX04335.1 - 1.6e-19 70.0 0.5 3.3e-19 68.9 0.5 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04335.1 - 0.0011 19.0 11.8 0.0023 18.0 11.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_fiss_reg PF05308.11 EFX04335.1 - 0.15 12.1 3.5 0.28 11.2 3.5 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator peroxidase PF00141.23 EFX04336.1 - 2.2e-81 272.9 0.0 6.7e-44 150.3 0.0 2.4 2 1 0 2 2 2 2 Peroxidase DLH PF01738.18 EFX04337.1 - 3.1e-19 69.4 0.4 2.4e-17 63.2 0.4 2.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EFX04337.1 - 0.025 14.5 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EFX04337.1 - 0.072 12.7 0.0 0.23 11.0 0.0 1.9 2 1 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX04337.1 - 0.092 12.2 0.4 1.5 8.3 0.0 2.4 3 0 0 3 3 3 0 Prolyl oligopeptidase family Aim21 PF11489.8 EFX04338.1 - 4e-172 574.8 66.6 4e-172 574.8 66.6 2.2 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 Hom_end PF05204.14 EFX04339.1 - 0.15 12.3 0.6 16 5.8 0.0 2.5 2 2 0 2 2 2 0 Homing endonuclease Aldo_ket_red PF00248.21 EFX04340.1 - 0.023 13.9 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Aldo/keto reductase family Clat_adaptor_s PF01217.20 EFX04341.1 - 1.3e-14 54.3 1.0 1.7e-13 50.7 1.0 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Syntaxin-6_N PF09177.11 EFX04342.1 - 0.029 14.9 0.0 0.088 13.4 0.0 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Sec20 PF03908.13 EFX04342.1 - 0.039 13.9 1.0 0.089 12.7 0.0 2.1 2 0 0 2 2 2 0 Sec20 Hydin_ADK PF17213.3 EFX04342.1 - 3.9 7.7 6.7 0.63 10.3 2.1 1.9 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain RRM_1 PF00076.22 EFX04343.1 - 9.3e-40 134.3 0.2 2.3e-19 69.0 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head PF16208.5 EFX04343.1 - 0.012 15.7 30.3 0.012 15.7 30.3 1.9 2 0 0 2 2 2 0 Keratin type II head RRM_7 PF16367.5 EFX04343.1 - 0.016 15.3 0.1 8.6 6.6 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif BUD22 PF09073.10 EFX04343.1 - 0.08 12.3 55.9 0.13 11.6 55.9 1.3 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 EFX04343.1 - 5.3 5.5 23.0 6.6 5.2 23.0 1.2 1 0 0 1 1 1 0 Macoilin family V-SNARE_C PF12352.8 EFX04344.1 - 2.9e-15 56.3 0.4 2.9e-15 56.3 0.4 2.4 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFX04344.1 - 0.00048 20.0 0.0 0.0013 18.6 0.0 1.8 1 0 0 1 1 1 1 Sec20 Sigma70_r4 PF04545.16 EFX04344.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 Snapin_Pallidin PF14712.6 EFX04344.1 - 0.034 14.6 1.0 12 6.4 0.1 2.6 3 0 0 3 3 3 0 Snapin/Pallidin HBM PF16591.5 EFX04344.1 - 0.04 13.4 1.4 0.13 11.7 0.9 2.0 1 1 1 2 2 2 0 Helical bimodular sensor domain Lectin_N PF03954.14 EFX04344.1 - 0.057 13.2 1.9 0.75 9.5 0.2 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Spc7 PF08317.11 EFX04344.1 - 0.077 11.9 0.9 0.17 10.7 0.1 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Yop-YscD_ppl PF16693.5 EFX04344.1 - 0.14 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Inner membrane component of T3SS, periplasmic domain TPR_MLP1_2 PF07926.12 EFX04344.1 - 0.21 11.6 4.3 0.71 9.9 0.8 2.8 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Sec2p PF06428.11 EFX04344.1 - 0.36 10.8 2.9 3.4 7.7 0.1 2.6 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p PspB PF06667.12 EFX04344.1 - 0.48 10.5 3.4 1.3 9.2 3.4 1.7 1 0 0 1 1 1 0 Phage shock protein B Metal_resist PF13801.6 EFX04344.1 - 1.5 9.0 9.0 1.1 9.5 0.5 3.3 2 2 1 3 3 3 0 Heavy-metal resistance Chitin_synth_1 PF01644.17 EFX04345.1 - 3.9e-74 248.0 0.2 6e-74 247.4 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EFX04345.1 - 6.6e-29 99.7 0.0 1.3e-28 98.7 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EFX04345.1 - 8.1e-24 84.1 1.3 4.6e-18 65.1 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Ank_2 PF12796.7 EFX04346.1 - 9.7e-53 176.7 0.1 3.2e-11 43.7 0.0 6.1 5 1 2 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX04346.1 - 3.8e-43 145.3 2.8 2.1e-06 28.2 0.0 9.6 6 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX04346.1 - 6.7e-36 118.2 8.9 0.00044 20.5 0.0 12.8 14 0 0 14 14 14 8 Ankyrin repeat Ank_5 PF13857.6 EFX04346.1 - 4.1e-34 116.2 6.1 9.1e-05 22.7 0.1 10.7 5 2 6 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 EFX04346.1 - 1.1e-23 82.6 14.7 0.016 15.6 0.0 12.0 12 2 0 12 12 12 6 Ankyrin repeat HSP70 PF00012.20 EFX04347.1 - 0.77 7.9 7.6 1 7.5 7.6 1.1 1 0 0 1 1 1 0 Hsp70 protein PGP_phosphatase PF09419.10 EFX04348.1 - 4.7e-62 208.5 0.0 6.9e-62 208.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EFX04348.1 - 0.0011 19.0 0.0 0.0025 17.8 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Brix PF04427.18 EFX04349.1 - 1.4e-28 100.3 0.1 1.8e-28 100.0 0.1 1.1 1 0 0 1 1 1 1 Brix domain Dioxygenase_C PF00775.21 EFX04350.1 - 2.3e-10 40.2 0.0 4.1e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Dioxygenase LepA_C PF06421.12 EFX04350.1 - 0.45 10.7 1.8 0.76 10.0 1.8 1.3 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus ORC2 PF04084.14 EFX04351.1 - 3.3e-105 351.7 0.0 4.1e-105 351.3 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 adh_short_C2 PF13561.6 EFX04353.1 - 1.8e-34 119.4 3.8 5.9e-33 114.4 3.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX04353.1 - 1.3e-32 112.8 0.7 3.7e-31 108.1 0.7 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX04353.1 - 7e-05 22.8 2.5 0.00022 21.2 2.5 1.8 1 1 0 1 1 1 1 KR domain Carn_acyltransf PF00755.20 EFX04354.1 - 2e-202 674.0 0.0 2.2e-202 673.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PP2C PF00481.21 EFX04355.1 - 6.1e-37 127.7 0.0 9.4e-31 107.4 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C Bac_luciferase PF00296.20 EFX04356.1 - 8e-63 212.7 4.4 1.8e-62 211.6 4.4 1.5 1 1 0 1 1 1 1 Luciferase-like monooxygenase Amidase PF01425.21 EFX04357.1 - 3.1e-69 234.1 1.9 1.4e-44 152.8 0.0 3.5 2 1 0 2 2 2 2 Amidase PRELI PF04707.14 EFX04358.1 - 3.6e-39 134.1 0.0 4.6e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family ubiquitin PF00240.23 EFX04359.1 - 1.2e-18 66.6 0.0 1.7e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EFX04359.1 - 7.6e-07 28.9 0.0 1.6e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EFX04359.1 - 0.00037 20.3 0.0 0.00057 19.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFX04359.1 - 0.0013 18.8 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 EFX04359.1 - 0.02 14.9 0.0 0.05 13.6 0.0 1.6 2 0 0 2 2 2 0 HOIP UBA domain pair DUF2407 PF10302.9 EFX04359.1 - 0.085 13.4 0.0 0.15 12.7 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Arginase PF00491.21 EFX04360.1 - 3.8e-85 285.8 0.8 5.4e-85 285.3 0.8 1.2 1 0 0 1 1 1 1 Arginase family ADH_zinc_N_2 PF13602.6 EFX04360.1 - 0.1 13.7 0.0 0.24 12.4 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase DUF1772 PF08592.11 EFX04361.1 - 8.3e-24 84.5 12.0 8.3e-24 84.5 12.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) SET PF00856.28 EFX04361.1 - 4.2e-09 37.0 0.1 4.9e-08 33.5 0.0 2.5 2 1 0 2 2 2 1 SET domain Goodbye PF17109.5 EFX04362.1 - 1.5e-20 73.9 0.0 7.2e-20 71.7 0.0 2.3 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EFX04362.1 - 2.4e-05 24.8 0.4 0.1 12.9 0.0 4.2 3 1 1 4 4 4 1 AAA ATPase domain NACHT PF05729.12 EFX04362.1 - 0.00045 20.2 0.1 0.0019 18.1 0.0 2.0 2 0 0 2 2 2 1 NACHT domain TPR_12 PF13424.6 EFX04362.1 - 0.0035 17.6 2.8 0.23 11.7 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_14 PF13173.6 EFX04362.1 - 0.022 14.8 0.0 0.14 12.2 0.0 2.4 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 EFX04362.1 - 0.12 12.3 0.0 0.6 10.1 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TPR_10 PF13374.6 EFX04362.1 - 0.13 12.2 0.1 2.1 8.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_22 PF13401.6 EFX04362.1 - 0.17 12.1 0.4 1.1 9.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain TPR_2 PF07719.17 EFX04362.1 - 0.35 11.1 1.4 1.7 8.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Plus-3 PF03126.18 EFX04363.1 - 1.5e-29 102.7 0.0 4.8e-29 101.1 0.0 1.9 1 0 0 1 1 1 1 Plus-3 domain NmrA PF05368.13 EFX04364.1 - 1.3e-19 70.7 0.0 1.6e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX04364.1 - 3.8e-13 49.7 2.8 3.8e-13 49.7 2.8 2.1 2 1 0 2 2 2 1 NAD(P)H-binding F420_oxidored PF03807.17 EFX04364.1 - 0.014 15.9 0.2 0.034 14.7 0.2 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EFX04364.1 - 0.02 15.3 0.3 0.088 13.2 0.3 2.0 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EFX04364.1 - 0.12 11.9 0.4 0.57 9.6 0.2 2.1 1 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EFX04364.1 - 0.14 12.3 0.1 0.81 9.8 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Alg6_Alg8 PF03155.15 EFX04366.1 - 4.3e-172 573.4 27.1 5e-172 573.2 27.1 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Transglut_core PF01841.19 EFX04367.1 - 8.5e-15 55.2 0.0 1.9e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Gln_amidase PF15644.6 EFX04367.1 - 0.027 15.5 0.3 0.09 13.8 0.0 2.1 2 0 0 2 2 2 0 Papain fold toxin 1, glutamine deamidase DUF3987 PF13148.6 EFX04367.1 - 3.2 6.7 5.6 0.26 10.3 0.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) CDC45 PF02724.14 EFX04368.1 - 2.2e-241 802.7 0.0 5.1e-217 722.2 0.0 3.3 1 1 2 3 3 3 2 CDC45-like protein XPG_I_2 PF12813.7 EFX04368.1 - 3.3e-53 180.7 0.0 6.9e-53 179.7 0.0 1.5 1 0 0 1 1 1 1 XPG domain containing Nop25 PF09805.9 EFX04368.1 - 0.0092 16.5 16.0 0.0092 16.5 16.0 2.0 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) CSRNP_N PF16019.5 EFX04368.1 - 0.11 12.4 3.2 0.21 11.5 3.2 1.4 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus BUD22 PF09073.10 EFX04368.1 - 0.14 11.5 33.0 0.1 11.9 17.6 2.2 2 0 0 2 2 2 0 BUD22 CNDH2_C PF16858.5 EFX04368.1 - 0.46 10.3 9.8 1 9.1 9.8 1.5 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4407 PF14362.6 EFX04368.1 - 7.4 5.8 5.8 13 5.0 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SGL PF08450.12 EFX04369.1 - 1.5e-25 90.3 0.0 3.7e-25 88.9 0.0 1.8 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFX04369.1 - 5.4e-05 23.3 0.0 0.00018 21.7 0.0 1.9 1 1 0 1 1 1 1 Arylesterase Str_synth PF03088.16 EFX04369.1 - 0.0026 17.9 0.0 0.012 15.8 0.0 2.1 1 1 0 1 1 1 1 Strictosidine synthase ADH_zinc_N PF00107.26 EFX04370.1 - 1.2e-20 73.8 0.3 3.4e-20 72.3 0.2 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX04370.1 - 9.5e-20 72.0 0.0 1.8e-19 71.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX04370.1 - 1.3e-08 34.6 0.0 7.1e-07 29.1 0.0 2.4 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain DnaJ PF00226.31 EFX04371.1 - 6.2e-12 45.5 0.0 9.7e-12 44.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3130 PF11328.8 EFX04371.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 Ntox15 PF15604.6 EFX04371.1 - 0.22 11.6 0.0 0.42 10.7 0.0 1.4 1 0 0 1 1 1 0 Novel toxin 15 TPR_2 PF07719.17 EFX04372.1 - 2.2e-07 30.4 1.4 2.9 8.2 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX04372.1 - 3.2e-05 24.1 1.3 0.16 12.3 0.0 4.6 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFX04372.1 - 0.00012 22.6 5.0 0.13 12.8 0.3 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX04372.1 - 0.00013 22.6 15.5 1.5 9.6 0.3 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFX04372.1 - 0.0027 18.0 0.6 11 6.7 0.0 4.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFX04372.1 - 0.076 13.3 0.0 8.1 6.9 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFX04372.1 - 0.12 13.3 13.5 2.8 9.0 0.1 6.1 6 1 1 7 7 7 0 Tetratricopeptide repeat DEAD PF00270.29 EFX04375.1 - 1.3e-25 90.2 0.0 2.5e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Sec63 PF02889.16 EFX04375.1 - 2.9e-19 69.2 0.4 7.7e-19 67.9 0.4 1.7 1 1 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 EFX04375.1 - 1.1e-11 45.0 0.0 2.8e-10 40.5 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX04375.1 - 2.3e-09 37.5 0.0 5e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFX04375.1 - 0.0033 17.2 0.0 0.0068 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX04375.1 - 0.0051 17.1 2.2 0.02 15.2 0.0 2.8 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EFX04375.1 - 0.0062 16.8 0.0 0.024 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF2847 PF11009.8 EFX04375.1 - 0.011 15.6 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) T2SSE PF00437.20 EFX04375.1 - 0.024 13.7 0.0 0.13 11.3 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF4238 PF14022.6 EFX04376.1 - 4.3e-60 203.5 0.0 9.2e-60 202.5 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4238) Ribosomal_L7Ae PF01248.26 EFX04377.1 - 1.2e-21 76.3 0.5 2.1e-21 75.4 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CLPTM1 PF05602.12 EFX04377.1 - 0.09 11.8 0.1 0.1 11.6 0.1 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) DAO PF01266.24 EFX04378.1 - 5.2e-28 98.6 4.6 6.4e-28 98.3 4.6 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX04378.1 - 0.0037 17.3 0.0 0.0073 16.3 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EFX04378.1 - 0.0046 16.1 0.8 0.0058 15.8 0.8 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFX04378.1 - 0.006 16.8 0.2 0.023 14.9 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX04378.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX04378.1 - 0.068 13.7 0.2 0.15 12.6 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase WAC_Acf1_DNA_bd PF10537.9 EFX04380.1 - 4.4e-38 129.9 0.2 1.2e-37 128.5 0.2 1.8 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EFX04380.1 - 4.9e-18 65.4 0.0 4.9e-18 65.4 0.0 2.8 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EFX04380.1 - 7.5e-18 64.6 0.3 1.5e-17 63.7 0.3 1.5 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EFX04380.1 - 2e-09 36.8 0.3 1.4e-08 34.0 0.0 2.5 3 0 0 3 3 3 1 WSTF, HB1, Itc1p, MBD9 motif 1 CENP-B_dimeris PF09026.10 EFX04380.1 - 0.66 10.4 8.4 11 6.5 8.4 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain MFS_1 PF07690.16 EFX04382.1 - 3.1e-09 36.2 7.9 3.1e-09 36.2 7.9 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFX04382.1 - 2e-06 27.6 3.2 2e-06 27.6 3.2 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Methyltransf_25 PF13649.6 EFX04383.1 - 6e-15 55.7 0.0 9.8e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04383.1 - 1.7e-14 54.2 0.0 2.9e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04383.1 - 8.3e-10 39.3 0.0 1.5e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04383.1 - 5.5e-07 29.5 0.0 7.8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX04383.1 - 3.7e-06 26.9 0.0 6.4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFX04383.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Acyl_transf_3 PF01757.22 EFX04384.1 - 2.9e-24 85.8 20.4 3.1e-24 85.7 19.9 1.3 1 1 0 1 1 1 1 Acyltransferase family DUF2975 PF11188.8 EFX04384.1 - 0.061 13.2 0.8 0.88 9.5 0.2 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF2975) CoA_trans PF01144.23 EFX04385.1 - 2.3e-97 324.6 0.8 6.1e-60 202.3 0.1 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 EFX04385.1 - 0.087 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain Metallophos PF00149.28 EFX04386.1 - 1.2e-14 55.4 0.0 2.2e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFX04386.1 - 7.9e-12 45.6 3.2 1.6e-11 44.6 3.2 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFX04386.1 - 1.9e-09 38.2 0.1 5.4e-09 36.8 0.1 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C PhoD_N PF16655.5 EFX04386.1 - 0.00069 20.1 0.6 0.003 18.1 0.2 2.1 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain fn3 PF00041.21 EFX04386.1 - 0.13 12.6 1.1 0.26 11.7 1.1 1.4 1 0 0 1 1 1 0 Fibronectin type III domain CLPTM1 PF05602.12 EFX04387.1 - 3.7e-152 507.3 0.0 4.6e-152 507.0 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF1772 PF08592.11 EFX04387.1 - 1.3 9.4 3.9 2.2 8.6 2.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Formyl_trans_N PF00551.19 EFX04388.1 - 4.2e-38 130.9 0.2 5.6e-38 130.5 0.2 1.1 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 EFX04388.1 - 2.9e-10 39.7 0.1 1.8e-09 37.2 0.0 2.3 2 0 0 2 2 2 1 ACT domain ACT_6 PF13740.6 EFX04388.1 - 4.1e-06 26.7 0.2 3.3e-05 23.8 0.0 2.5 3 0 0 3 3 3 1 ACT domain ACT_4 PF13291.6 EFX04388.1 - 0.035 14.7 0.0 0.11 13.1 0.0 1.9 2 0 0 2 2 2 0 ACT domain Peptidase_S8 PF00082.22 EFX04389.1 - 1.4e-15 57.3 0.2 9.4e-15 54.6 0.2 2.1 1 1 0 1 1 1 1 Subtilase family MnmE_helical PF12631.7 EFX04389.1 - 0.08 13.1 0.0 0.1 12.7 0.0 1.3 1 1 0 1 1 1 0 MnmE helical domain Cullin PF00888.22 EFX04390.1 - 3.1e-189 630.6 4.4 4.3e-189 630.1 4.4 1.1 1 0 0 1 1 1 1 Cullin family PDZ_1 PF12812.7 EFX04390.1 - 8.5e-51 169.9 0.0 8.9e-33 112.2 0.0 2.7 2 0 0 2 2 2 2 PDZ-like domain Cullin_Nedd8 PF10557.9 EFX04390.1 - 1.2e-25 89.3 2.6 3.5e-25 87.8 2.6 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain Trypsin_2 PF13365.6 EFX04390.1 - 2.8e-24 86.7 1.4 6.3e-21 75.8 0.1 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 EFX04390.1 - 1.6e-17 63.0 0.5 0.00017 21.3 0.1 4.7 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 EFX04390.1 - 6.4e-14 52.0 3.1 0.00011 22.5 0.0 4.7 4 0 0 4 4 4 4 PDZ domain PDZ PF00595.24 EFX04390.1 - 2e-08 34.5 0.0 0.013 15.8 0.0 3.7 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 EFX04390.1 - 0.0068 16.4 1.1 0.67 10.0 0.2 3.6 4 0 0 4 4 4 1 Tricorn protease PDZ domain 4HPAD_g_N PF18671.1 EFX04390.1 - 0.17 11.6 0.2 0.62 9.8 0.0 2.1 2 0 0 2 2 2 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal PLDc PF00614.22 EFX04391.1 - 2.1e-15 56.2 1.1 1.8e-07 31.1 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFX04391.1 - 3.2e-14 52.9 0.0 2.5e-05 24.1 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain Methyltransf_16 PF10294.9 EFX04392.1 - 7.1e-40 136.6 0.0 8.6e-40 136.3 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 EFX04392.1 - 0.2 11.4 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PBP PF01161.20 EFX04393.1 - 4.9e-08 33.4 0.0 8.5e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ETF PF01012.21 EFX04394.1 - 8.1e-45 152.9 3.4 1.3e-44 152.3 3.4 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EFX04394.1 - 1.5e-33 114.6 0.4 4.2e-33 113.2 0.4 1.8 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Tau95 PF09734.9 EFX04395.1 - 3.1e-36 125.3 0.0 7.2e-36 124.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EFX04395.1 - 3e-28 98.5 0.0 3e-28 98.5 0.0 2.3 2 1 0 2 2 2 1 Tau95 Triple barrel domain SDA1 PF05285.12 EFX04395.1 - 2 7.8 48.9 3 7.2 48.9 1.2 1 0 0 1 1 1 0 SDA1 DUF4045 PF13254.6 EFX04395.1 - 2.9 7.4 13.3 4.5 6.8 13.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Drc1-Sld2 PF11719.8 EFX04395.1 - 3.1 7.3 21.4 5.8 6.3 21.4 1.4 1 0 0 1 1 1 0 DNA replication and checkpoint protein zf-C2H2_jaz PF12171.8 EFX04396.1 - 0.016 15.5 0.2 0.016 15.5 0.2 4.0 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EFX04396.1 - 0.045 14.2 20.4 0.16 12.5 0.2 4.9 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-met PF12874.7 EFX04396.1 - 0.13 12.7 0.2 0.13 12.7 0.2 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EFX04396.1 - 0.16 12.9 0.1 0.16 12.9 0.1 5.8 6 0 0 6 6 6 0 C2H2-type zinc finger zf_ZIC PF18366.1 EFX04396.1 - 0.16 12.1 4.2 2.6 8.2 0.1 3.3 3 0 0 3 3 3 0 Zic proteins zinc finger domain FTHFS PF01268.19 EFX04398.1 - 1.1e-254 845.8 0.1 1.5e-254 845.3 0.1 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EFX04398.1 - 1.2e-67 226.2 1.9 2.3e-67 225.3 0.4 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EFX04398.1 - 4.6e-38 130.0 0.3 9.9e-38 129.0 0.3 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Helicase_C_4 PF13871.6 EFX04398.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue DUF507 PF04368.13 EFX04398.1 - 0.22 11.5 0.1 0.53 10.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF507) MFS_1 PF07690.16 EFX04399.1 - 2e-27 96.1 26.4 9e-27 93.9 25.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Beta-lactamase PF00144.24 EFX04400.1 - 9.1e-45 153.3 7.1 1.7e-44 152.4 7.1 1.3 1 0 0 1 1 1 1 Beta-lactamase NTF2 PF02136.20 EFX04400.1 - 2.6e-28 99.0 0.2 4.6e-28 98.2 0.2 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF3471 PF11954.8 EFX04400.1 - 1.2e-08 35.3 0.8 3.4e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3471) Fungal_trans PF04082.18 EFX04401.1 - 2.7e-08 33.2 0.0 5.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04401.1 - 1.4e-05 25.1 7.1 2.8e-05 24.1 7.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.19 EFX04401.1 - 8.1 6.2 12.4 20 4.9 12.4 1.7 1 0 0 1 1 1 0 SPX domain PNGaseA PF12222.8 EFX04402.1 - 1.1e-176 587.9 2.2 1.5e-176 587.6 2.2 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Not1 PF04054.15 EFX04403.1 - 5.5e-120 400.7 0.1 1.2e-119 399.5 0.1 1.6 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EFX04403.1 - 4.9e-88 294.3 2.3 4.9e-88 294.3 2.3 1.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EFX04403.1 - 1.7e-46 157.8 1.5 4e-46 156.6 1.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EFX04403.1 - 1.4e-44 151.5 0.1 4.5e-44 149.9 0.1 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EFX04403.1 - 1.3e-37 129.1 0.0 7.7e-37 126.7 0.0 2.3 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Fungal_trans PF04082.18 EFX04404.1 - 1.1e-09 37.7 0.0 2e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04404.1 - 2.4e-05 24.3 11.0 4.2e-05 23.6 11.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Bd3614-deam PF14439.6 EFX04404.1 - 2.5 8.2 4.9 6.6 6.8 4.9 1.7 1 0 0 1 1 1 0 Bd3614-like deaminase Glyco_hydro_20 PF00728.22 EFX04405.1 - 3e-21 76.2 0.7 1.4e-19 70.7 0.0 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 EFX04405.1 - 2.5e-05 25.0 0.0 8.5e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 p450 PF00067.22 EFX04406.1 - 4.8e-43 147.6 0.0 1.9e-42 145.6 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF1242 PF06842.12 EFX04407.1 - 8.8e-19 67.0 0.3 1.3e-18 66.5 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Peptidase_M50B PF13398.6 EFX04408.1 - 1.1e-57 195.0 18.2 1.4e-57 194.6 18.2 1.1 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.22 EFX04408.1 - 0.029 13.6 0.8 0.056 12.7 0.4 1.7 2 0 0 2 2 2 0 Peptidase family M50 Peptidase_M41 PF01434.18 EFX04408.1 - 0.049 13.5 0.2 0.078 12.8 0.2 1.2 1 0 0 1 1 1 0 Peptidase family M41 Neurensin PF14927.6 EFX04408.1 - 7.8 6.2 6.7 5.4 6.7 0.1 2.8 2 1 1 3 3 3 0 Neurensin DHHC PF01529.20 EFX04409.1 - 1.2e-31 109.6 5.9 1.2e-31 109.6 5.9 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.6 EFX04409.1 - 0.15 12.0 1.7 0.33 10.8 1.7 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily Abhydrolase_3 PF07859.13 EFX04410.1 - 4e-41 141.2 4.1 4.9e-33 114.8 1.6 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EFX04410.1 - 0.00077 18.4 1.5 0.0089 14.9 1.5 2.0 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EFX04410.1 - 0.0035 16.3 0.0 0.0049 15.8 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Esterase_phd PF10503.9 EFX04410.1 - 0.005 16.4 0.2 0.013 15.0 0.2 1.6 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EFX04410.1 - 0.023 14.2 0.7 1.9 7.9 0.3 2.5 2 0 0 2 2 2 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EFX04410.1 - 0.044 12.7 0.0 0.079 11.9 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydro_lipase PF04083.16 EFX04410.1 - 0.051 13.2 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region AXE1 PF05448.12 EFX04410.1 - 0.068 11.8 0.1 0.11 11.1 0.1 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pkinase PF00069.25 EFX04411.1 - 1.5e-69 234.3 0.0 1.9e-69 234.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04411.1 - 3.1e-31 108.6 0.0 4.4e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EFX04411.1 - 1.1e-11 45.2 0.3 1.1e-11 45.2 0.3 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EFX04411.1 - 1.5e-10 41.2 0.0 4.2e-08 33.4 0.0 2.5 2 0 0 2 2 2 1 C2 domain Kinase-like PF14531.6 EFX04411.1 - 6.3e-09 35.6 0.0 2.5e-08 33.6 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFX04411.1 - 0.0014 17.6 0.1 0.0029 16.6 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFX04411.1 - 0.033 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFX04411.1 - 0.041 13.5 0.1 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EFX04411.1 - 0.065 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Adeno_E3_15_3 PF03307.14 EFX04411.1 - 0.086 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region APH PF01636.23 EFX04411.1 - 0.19 11.6 0.9 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Cript PF10235.9 EFX04412.1 - 7.3e-13 48.9 3.3 7.3e-13 48.9 3.3 1.8 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT zinc_ribbon_15 PF17032.5 EFX04412.1 - 0.0003 21.5 1.6 0.021 15.5 0.3 2.1 2 0 0 2 2 2 2 zinc-ribbon family DZR PF12773.7 EFX04412.1 - 0.12 12.4 6.8 0.96 9.5 6.9 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf_UBZ PF18439.1 EFX04412.1 - 0.83 9.3 4.7 18 5.0 1.5 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger ADH_N PF08240.12 EFX04412.1 - 3.7 7.5 6.9 2.9 7.8 1.1 2.7 1 1 2 3 3 3 0 Alcohol dehydrogenase GroES-like domain IU_nuc_hydro PF01156.19 EFX04413.1 - 1.1e-80 271.4 0.1 1.3e-80 271.2 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase FtsK_4TM PF13491.6 EFX04413.1 - 0.093 12.4 1.3 0.25 11.0 1.3 1.7 1 0 0 1 1 1 0 4TM region of DNA translocase FtsK/SpoIIIE MCPsignal PF00015.21 EFX04414.1 - 0.024 14.4 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain G-patch PF01585.23 EFX04415.1 - 4.6e-06 26.4 0.3 6.5e-05 22.7 0.3 2.8 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFX04415.1 - 3.7e-05 23.7 0.0 3.7e-05 23.7 0.0 3.8 3 0 0 3 3 3 1 G-patch domain CDC27 PF09507.10 EFX04415.1 - 0.052 12.9 41.9 0.066 12.6 41.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GREB1 PF15782.5 EFX04415.1 - 0.6 7.2 20.3 0.79 6.8 20.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 EFX04415.1 - 0.92 8.0 21.3 1.2 7.6 21.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF936 PF06075.12 EFX04415.1 - 1.3 7.8 31.8 1.7 7.5 31.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) LAP1C PF05609.12 EFX04415.1 - 2 7.4 24.3 2.7 7.0 24.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hid1 PF12722.7 EFX04415.1 - 3.5 5.6 21.6 4.6 5.2 21.6 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF966 PF06136.13 EFX04415.1 - 3.5 7.2 25.9 4.9 6.8 25.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TRAPPC-Trs85 PF12739.7 EFX04416.1 - 3.2e-113 378.8 0.5 5.6e-112 374.7 0.0 2.3 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Zn_clus PF00172.18 EFX04416.1 - 7.4e-08 32.4 8.9 1.5e-07 31.4 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2722 PF10846.8 EFX04416.1 - 0.026 13.5 8.7 0.05 12.6 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SprA-related PF12118.8 EFX04416.1 - 0.054 12.6 9.8 0.11 11.6 9.8 1.4 1 0 0 1 1 1 0 SprA-related family Fungal_trans PF04082.18 EFX04416.1 - 0.2 10.7 0.0 0.2 10.7 0.0 2.2 2 0 0 2 2 2 0 Fungal specific transcription factor domain TFIIA PF03153.13 EFX04416.1 - 0.3 11.0 17.5 0.034 14.2 10.9 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 EFX04416.1 - 0.3 11.0 3.5 0.69 9.8 3.5 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pex14_N PF04695.13 EFX04416.1 - 0.48 11.1 10.0 0.38 11.4 5.6 2.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Activator_LAG-3 PF11498.8 EFX04416.1 - 0.5 9.3 18.1 0.82 8.6 18.1 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CCDC53 PF10152.9 EFX04416.1 - 0.82 10.1 5.6 1.6 9.2 2.8 2.7 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex Spt20 PF12090.8 EFX04416.1 - 8.8 5.9 21.7 16 5.0 21.7 1.3 1 0 0 1 1 1 0 Spt20 family Exo84_C PF16528.5 EFX04417.1 - 8.6e-75 251.0 1.2 8.6e-75 251.0 1.2 2.0 3 0 0 3 3 3 1 Exocyst component 84 C-terminal Metallophos PF00149.28 EFX04417.1 - 4.1e-37 128.7 0.5 7.1e-37 127.9 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Vps51 PF08700.11 EFX04417.1 - 2.5e-15 56.3 3.1 2.5e-15 56.3 3.1 2.6 3 0 0 3 3 3 1 Vps51/Vps67 STPPase_N PF16891.5 EFX04417.1 - 0.1 13.1 0.1 0.33 11.4 0.1 1.9 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain COG2 PF06148.11 EFX04417.1 - 0.13 12.3 2.8 2.6 8.2 0.1 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RecX PF02631.16 EFX04417.1 - 0.29 11.6 3.0 2.1 8.8 0.5 2.7 2 0 0 2 2 2 0 RecX family Spc29 PF17082.5 EFX04417.1 - 7.4 6.3 9.9 3.9 7.2 0.4 3.4 3 1 0 3 3 3 0 Spindle Pole Component 29 Crystall PF00030.19 EFX04418.1 - 8.6e-05 22.7 0.1 0.0023 18.1 0.0 2.4 2 0 0 2 2 2 1 Beta/Gamma crystallin Syntaxin-6_N PF09177.11 EFX04418.1 - 0.061 13.9 0.0 0.089 13.3 0.0 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Inhibitor_I36 PF03995.13 EFX04418.1 - 0.2 11.6 3.0 3.5 7.6 1.1 2.9 2 1 1 3 3 3 0 Peptidase inhibitor family I36 betaPIX_CC PF16523.5 EFX04419.1 - 0.12 12.2 0.2 0.24 11.2 0.2 1.5 1 0 0 1 1 1 0 betaPIX coiled coil Snf7 PF03357.21 EFX04420.1 - 5.4e-16 58.7 13.4 8.7e-16 58.0 13.4 1.3 1 0 0 1 1 1 1 Snf7 HAUS-augmin3 PF14932.6 EFX04420.1 - 0.0047 16.5 4.2 0.0047 16.5 4.2 2.2 1 1 1 2 2 2 1 HAUS augmin-like complex subunit 3 Sua5_yciO_yrdC PF01300.18 EFX04421.1 - 1.8e-48 164.4 0.0 2.8e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EFX04421.1 - 4.5e-29 101.7 0.0 6.8e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Tma16 PF11176.8 EFX04423.1 - 1.1e-46 158.4 0.9 1.3e-46 158.1 0.9 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 FKBP_C PF00254.28 EFX04424.1 - 1.5e-29 102.2 0.0 5e-29 100.5 0.0 2.0 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EFX04424.1 - 2.5e-29 101.9 5.0 2.5e-29 101.9 5.0 2.9 2 2 0 2 2 2 1 Nucleoplasmin-like domain Aldedh PF00171.22 EFX04425.1 - 3.9e-50 170.7 0.0 5.2e-30 104.4 0.0 3.5 3 1 0 3 3 3 3 Aldehyde dehydrogenase family SH3_13 PF18335.1 EFX04425.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain COPIIcoated_ERV PF07970.12 EFX04426.1 - 6.1e-34 117.8 0.0 8.9e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFX04426.1 - 6.5e-25 87.3 0.0 1e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LSM PF01423.22 EFX04427.1 - 2.2e-21 75.3 0.6 2.5e-21 75.1 0.6 1.1 1 0 0 1 1 1 1 LSM domain MIF PF01187.18 EFX04428.1 - 5.2e-09 36.4 0.0 7.9e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Methyltransf_33 PF10017.9 EFX04429.1 - 3.5e-87 292.4 0.0 5.8e-87 291.7 0.0 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 EFX04429.1 - 7.7e-15 55.2 0.1 1.3e-13 51.2 0.1 2.4 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EFX04429.1 - 4.5e-05 24.0 0.2 0.0002 21.8 0.1 2.2 2 0 0 2 2 2 1 DinB superfamily CDK5_activator PF03261.15 EFX04430.1 - 0.1 12.1 1.8 0.12 11.9 1.8 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Myosin_head PF00063.21 EFX04431.1 - 4.5e-239 795.2 0.7 5.6e-239 794.9 0.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFX04431.1 - 1.5e-46 158.4 0.0 2.7e-46 157.6 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EFX04431.1 - 1.5e-12 46.9 0.3 2.8e-12 46.0 0.3 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFX04431.1 - 1.1e-09 38.0 0.0 2.3e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFX04431.1 - 6.5e-08 32.1 0.1 1.4e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.12 EFX04431.1 - 0.0019 17.8 0.3 0.77 9.3 0.0 2.3 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain IQ PF00612.27 EFX04431.1 - 0.0085 15.8 10.3 0.38 10.7 2.6 2.8 1 1 1 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EFX04431.1 - 0.04 14.2 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX04431.1 - 0.12 12.7 0.0 0.37 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFX04431.1 - 0.15 12.6 0.0 0.41 11.2 0.0 1.8 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 EFX04431.1 - 0.2 11.6 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Merozoite_SPAM PF07133.11 EFX04432.1 - 0.0092 16.0 5.0 0.0092 16.0 5.0 3.3 3 0 0 3 3 3 1 Merozoite surface protein (SPAM) Sec16 PF12932.7 EFX04432.1 - 3.8 8.1 5.6 3.5 8.2 0.0 3.4 3 0 0 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region Prp18 PF02840.15 EFX04434.1 - 7e-51 172.0 0.2 1.8e-50 170.7 0.0 1.8 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EFX04434.1 - 2.9e-09 36.3 2.9 2.9e-09 36.3 2.9 3.2 4 0 0 4 4 4 1 pre-mRNA processing factor 4 (PRP4) like CDC27 PF09507.10 EFX04434.1 - 7.6 5.8 18.8 11 5.3 18.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Dsh_C PF12316.8 EFX04434.1 - 8 6.8 7.3 15 5.9 7.3 1.5 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Fe-ADH PF00465.19 EFX04435.1 - 1.2e-98 330.3 0.0 1.5e-98 330.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFX04435.1 - 6.4e-14 52.3 0.0 8.5e-11 42.0 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EFX04435.1 - 0.069 12.8 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Med6 PF04934.14 EFX04436.1 - 1.1e-35 122.3 0.9 1.4e-35 122.0 0.0 1.6 2 0 0 2 2 2 1 MED6 mediator sub complex component FAM176 PF14851.6 EFX04436.1 - 0.0099 15.5 8.0 0.017 14.8 0.5 2.4 2 0 0 2 2 2 1 FAM176 family SDA1 PF05285.12 EFX04436.1 - 0.15 11.5 22.3 0.25 10.7 22.3 1.3 1 0 0 1 1 1 0 SDA1 Afi1 PF07792.12 EFX04436.1 - 0.2 12.1 12.7 0.13 12.8 2.8 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PBP1_TM PF14812.6 EFX04436.1 - 0.26 11.7 30.1 0.15 12.5 16.4 2.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TLP-20 PF06088.11 EFX04436.1 - 0.65 9.9 9.3 0.88 9.4 1.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) KCNQ2_u3 PF16642.5 EFX04436.1 - 0.93 10.5 10.2 0.11 13.5 4.9 2.1 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 NOA36 PF06524.12 EFX04436.1 - 1.2 8.3 26.9 0.24 10.7 18.7 2.1 2 0 0 2 2 2 0 NOA36 protein RXT2_N PF08595.11 EFX04436.1 - 2.4 8.1 18.3 0.18 11.8 8.4 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 EFX04436.1 - 7.5 6.4 17.1 0.47 10.3 7.8 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region FYDLN_acid PF09538.10 EFX04436.1 - 7.7 7.3 25.9 8.8 7.1 15.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Rad51 PF08423.11 EFX04437.1 - 2.3e-121 403.9 0.0 2.8e-121 403.6 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EFX04437.1 - 2.8e-11 43.4 0.0 4e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EFX04437.1 - 1.6e-10 40.9 0.0 2.4e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFX04437.1 - 7.9e-09 35.2 0.0 2e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 EFX04437.1 - 3.6e-05 24.3 0.0 7.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_24 PF13479.6 EFX04437.1 - 0.016 14.9 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain PAXNEB PF05625.11 EFX04437.1 - 0.048 12.8 0.1 0.17 11.0 0.1 1.7 2 0 0 2 2 2 0 PAXNEB protein AAA_22 PF13401.6 EFX04437.1 - 0.065 13.5 0.2 0.27 11.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain RNA_pol_L_2 PF13656.6 EFX04438.1 - 9.3e-21 73.4 0.1 1.2e-20 73.0 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFX04438.1 - 5.1e-06 25.8 0.1 2.2e-05 23.8 0.1 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Iso_dh PF00180.20 EFX04439.1 - 1.1e-74 251.7 0.0 1.3e-74 251.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DHFR_2 PF06442.11 EFX04439.1 - 0.037 13.9 0.0 3.4 7.6 0.0 2.5 2 0 0 2 2 2 0 R67 dihydrofolate reductase CP2 PF04516.15 EFX04440.1 - 2.4e-78 262.6 0.0 5.2e-78 261.5 0.0 1.6 2 0 0 2 2 2 1 CP2 transcription factor Tektin PF03148.14 EFX04440.1 - 0.0066 15.2 0.1 0.012 14.4 0.1 1.3 1 0 0 1 1 1 1 Tektin family TMF_DNA_bd PF12329.8 EFX04440.1 - 0.04 13.9 0.6 0.075 13.0 0.6 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding AKNA PF12443.8 EFX04440.1 - 0.067 13.8 0.1 0.21 12.2 0.1 1.9 1 0 0 1 1 1 0 AT-hook-containing transcription factor Gti1_Pac2 PF09729.9 EFX04442.1 - 0.039 14.0 0.1 0.065 13.3 0.1 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family FBPase PF00316.20 EFX04443.1 - 9.4e-68 227.4 0.4 1.3e-67 227.0 0.4 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EFX04443.1 - 0.081 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family Cu-oxidase_3 PF07732.15 EFX04444.1 - 2.9e-38 130.6 4.2 2.9e-38 130.6 4.2 2.5 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EFX04444.1 - 3.5e-35 121.5 1.4 1.1e-34 119.9 0.7 2.1 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX04444.1 - 8.5e-27 93.6 0.8 8.5e-27 93.6 0.8 3.4 3 1 0 3 3 3 1 Multicopper oxidase Pro_CA PF00484.19 EFX04445.1 - 5.8e-46 156.6 0.1 7.2e-46 156.3 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase AAA PF00004.29 EFX04446.1 - 1.7e-15 57.6 0.0 5.4e-15 56.0 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX04446.1 - 0.0029 17.6 0.0 0.01 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFX04446.1 - 0.003 17.7 0.0 0.013 15.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFX04446.1 - 0.0042 17.4 1.6 0.1 12.9 1.6 2.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX04446.1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX04446.1 - 0.057 13.8 0.4 0.23 11.8 0.4 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFX04446.1 - 0.082 13.5 0.2 0.38 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Asp PF00026.23 EFX04447.1 - 1e-48 166.4 0.9 1.3e-48 166.0 0.9 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX04447.1 - 1.3e-11 45.0 1.0 1.1e-10 42.0 0.1 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX04447.1 - 6.6e-05 23.5 1.5 0.06 14.0 0.1 3.5 2 1 0 2 2 2 2 Aspartyl protease DUF1758 PF05585.12 EFX04447.1 - 0.21 11.3 2.2 0.46 10.2 0.3 2.4 3 0 0 3 3 3 0 Putative peptidase (DUF1758) INCENP_ARK-bind PF03941.15 EFX04449.1 - 5.3e-21 74.3 1.9 5.3e-21 74.3 1.9 2.8 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region Acetyltransf_10 PF13673.7 EFX04450.1 - 7.4e-10 38.9 0.0 1.5e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX04450.1 - 3.1e-09 37.1 0.0 5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX04450.1 - 4.8e-09 36.5 0.0 6.8e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFX04450.1 - 3.1e-05 23.9 0.0 5.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFX04450.1 - 0.0011 19.0 0.4 0.37 10.9 0.0 3.0 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFX04450.1 - 0.0017 18.4 0.0 0.0028 17.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase HD PF01966.22 EFX04451.1 - 6.6e-05 23.1 0.4 0.00035 20.8 0.4 2.2 1 1 0 1 1 1 1 HD domain Porin_3 PF01459.22 EFX04452.1 - 2.9e-64 217.1 7.8 1.4e-53 182.1 3.7 2.1 2 0 0 2 2 2 2 Eukaryotic porin Aldedh PF00171.22 EFX04453.1 - 1.8e-119 399.3 0.3 2.2e-119 399.0 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFX04453.1 - 0.00022 20.4 0.0 0.0015 17.6 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) DUF1612 PF07756.12 EFX04453.1 - 0.16 12.2 0.1 0.37 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) LRR_4 PF12799.7 EFX04454.1 - 0.00013 22.3 2.2 0.2 12.1 0.0 5.1 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFX04454.1 - 0.0051 16.6 2.6 1 9.2 0.0 4.0 4 0 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 EFX04454.1 - 0.34 11.6 5.8 79 4.4 0.1 5.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 EFX04454.1 - 3.8 7.8 16.3 4.2 7.7 0.1 5.9 8 0 0 8 8 8 0 Leucine Rich repeat SIS_2 PF13580.6 EFX04455.1 - 0.018 15.0 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 SIS domain F-box-like PF12937.7 EFX04456.1 - 1.6e-05 24.7 0.1 3.1e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX04456.1 - 0.00065 19.5 0.2 0.0029 17.4 0.2 2.1 2 0 0 2 2 2 1 F-box domain Bromodomain PF00439.25 EFX04457.1 - 2.4e-31 107.6 1.0 2.1e-15 56.5 0.0 2.3 2 0 0 2 2 2 2 Bromodomain Nop14 PF04147.12 EFX04457.1 - 0.015 13.6 9.7 0.02 13.2 9.7 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EFX04457.1 - 3 6.0 13.4 4.5 5.4 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 EFX04458.1 - 1e-18 67.7 0.0 2.4e-11 43.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain HEAT PF02985.22 EFX04458.1 - 1.6e-12 46.5 6.5 0.0066 16.6 0.0 7.1 6 0 0 6 6 6 2 HEAT repeat WD40 PF00400.32 EFX04458.1 - 1.3e-10 41.6 15.1 5.2e-08 33.4 0.1 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Cnd1 PF12717.7 EFX04458.1 - 4.4e-07 30.1 0.1 0.092 12.8 0.0 4.2 2 2 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFX04458.1 - 4.3e-06 27.0 9.6 0.092 13.2 0.0 5.6 4 1 1 5 5 5 3 HEAT repeats Pkinase_Tyr PF07714.17 EFX04458.1 - 1e-05 24.9 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_EZ PF13513.6 EFX04458.1 - 6.7e-05 23.3 5.1 0.015 15.8 0.4 4.1 3 0 0 3 3 3 2 HEAT-like repeat Adaptin_N PF01602.20 EFX04458.1 - 0.027 13.1 0.2 0.51 8.8 0.0 2.3 2 0 0 2 2 2 0 Adaptin N terminal region ANAPC4_WD40 PF12894.7 EFX04458.1 - 0.027 14.8 0.0 12 6.3 0.0 3.1 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EFX04458.1 - 0.13 11.0 0.0 6.2 5.4 0.0 2.5 3 0 0 3 3 3 0 Nup133 N terminal like Fungal_trans PF04082.18 EFX04460.1 - 2.8e-14 52.8 0.0 4.2e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04460.1 - 1.6e-08 34.5 8.0 2.7e-08 33.8 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain STE2 PF02116.15 EFX04461.1 - 3.3e-83 279.2 21.4 3.9e-83 279.0 21.4 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR Pex19 PF04614.12 EFX04462.1 - 7.5e-73 245.3 6.8 2.4e-72 243.6 6.8 1.8 1 1 0 1 1 1 1 Pex19 protein family GET2 PF08690.10 EFX04462.1 - 0.54 9.9 13.3 0.059 13.0 5.5 2.5 1 1 2 3 3 3 0 GET complex subunit GET2 TetR_C_28 PF17937.1 EFX04462.1 - 3.4 8.2 9.1 3.3 8.2 0.4 3.7 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Bud13 PF09736.9 EFX04463.1 - 1e-47 162.2 6.3 1e-47 162.2 6.3 2.6 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex Afi1 PF07792.12 EFX04463.1 - 7.9 7.0 6.5 19 5.7 5.0 2.3 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAD_binding_3 PF01494.19 EFX04464.1 - 1.5e-16 60.6 1.2 5.6e-09 35.7 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain ADC PF06314.11 EFX04464.1 - 2.3e-10 40.5 0.0 4e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Cupin_2 PF07883.11 EFX04464.1 - 2.5e-07 30.3 0.0 5.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Cupin domain NAD_binding_8 PF13450.6 EFX04464.1 - 1.2e-06 28.6 0.2 4e-06 26.9 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX04464.1 - 9.8e-06 24.9 1.2 1.9e-05 23.9 1.2 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX04464.1 - 2e-05 24.4 0.0 3.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX04464.1 - 4.7e-05 22.8 0.3 8.6e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX04464.1 - 7.9e-05 21.5 0.6 0.00011 21.0 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 EFX04464.1 - 0.00057 19.3 0.5 0.00095 18.6 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EFX04464.1 - 0.0029 16.5 0.3 0.0053 15.7 0.3 1.4 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox PF00070.27 EFX04464.1 - 0.0046 17.5 0.4 0.013 16.0 0.4 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX04464.1 - 0.0054 15.9 0.1 0.0083 15.2 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX04464.1 - 0.039 13.0 1.1 0.17 10.9 1.1 1.9 1 1 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 EFX04464.1 - 0.05 13.2 0.6 0.12 12.0 0.6 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EFX04464.1 - 0.11 11.8 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX04464.1 - 0.11 11.7 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Sld5 PF05916.11 EFX04464.1 - 0.13 12.7 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 GINS complex protein Amino_oxidase PF01593.24 EFX04464.1 - 0.15 11.4 0.8 0.4 9.9 0.1 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Cyt-b5 PF00173.28 EFX04465.1 - 2.8e-22 78.7 0.1 3.1e-22 78.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EFP_N PF08207.12 EFX04465.1 - 0.096 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain ParA PF10609.9 EFX04466.1 - 6.9e-89 297.5 0.0 8.1e-89 297.3 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFX04466.1 - 4.1e-12 46.3 0.0 1.8e-11 44.2 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EFX04466.1 - 5.9e-09 36.1 0.2 9.7e-08 32.1 0.2 2.1 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 EFX04466.1 - 1.8e-06 27.6 0.0 1.8e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 EFX04466.1 - 2.3e-06 27.0 0.1 0.00011 21.5 0.0 2.6 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EFX04466.1 - 7e-06 26.0 0.5 0.0029 17.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain MipZ PF09140.11 EFX04466.1 - 1.3e-05 24.7 0.0 2.6e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ AAA_25 PF13481.6 EFX04466.1 - 0.0012 18.5 0.1 0.003 17.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 EFX04466.1 - 0.0042 16.6 0.3 0.024 14.1 0.1 1.9 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 EFX04466.1 - 0.033 14.0 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 EFX04466.1 - 0.035 13.1 1.4 0.064 12.2 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 EFX04466.1 - 0.14 11.7 0.3 0.36 10.4 0.1 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Lactamase_B PF00753.27 EFX04467.1 - 0.00027 21.0 2.8 0.00047 20.2 1.5 1.9 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily CLTH PF10607.9 EFX04468.1 - 8.4e-32 110.1 0.1 1.2e-31 109.5 0.1 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EFX04468.1 - 5.5e-08 32.5 0.0 1.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 LisH Ureidogly_lyase PF04115.12 EFX04469.1 - 3.7e-58 196.4 0.0 4.9e-58 196.0 0.0 1.1 1 0 0 1 1 1 1 Ureidoglycolate lyase V_ATPase_I PF01496.19 EFX04471.1 - 0 1036.5 0.0 0 1036.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CheZ PF04344.13 EFX04471.1 - 0.052 13.5 1.2 0.24 11.3 0.1 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Nup54 PF13874.6 EFX04471.1 - 0.21 11.7 2.5 6 7.0 0.1 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DHR10 PF18595.1 EFX04471.1 - 0.22 11.6 10.8 0.087 12.9 4.0 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF1664 PF07889.12 EFX04471.1 - 0.23 11.5 3.0 8.4 6.4 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 EFX04471.1 - 0.26 11.8 0.7 12 6.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 Baculo_PEP_C PF04513.12 EFX04471.1 - 0.28 11.2 2.9 4.5 7.3 0.4 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus EzrA PF06160.12 EFX04471.1 - 0.37 8.9 5.0 0.92 7.6 0.8 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA HAUS-augmin3 PF14932.6 EFX04471.1 - 0.52 9.8 4.5 2 7.9 0.2 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Filament PF00038.21 EFX04471.1 - 0.7 9.4 9.8 1.2 8.7 0.4 2.5 2 1 0 2 2 2 0 Intermediate filament protein DASH_Dam1 PF08653.10 EFX04471.1 - 0.8 9.6 4.7 25 4.8 0.1 4.0 4 0 0 4 4 4 0 DASH complex subunit Dam1 Golgin_A5 PF09787.9 EFX04471.1 - 1.6 8.1 7.0 4.1 6.8 1.4 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 ZapB PF06005.12 EFX04471.1 - 5.3 7.6 6.6 4 8.0 1.7 2.4 2 0 0 2 2 2 0 Cell division protein ZapB MFS_1 PF07690.16 EFX04472.1 - 5.5e-27 94.6 38.1 5.5e-27 94.6 38.1 1.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Ubiquitin_4 PF18036.1 EFX04472.1 - 0.08 13.0 0.9 0.2 11.7 0.9 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Jacalin PF01419.17 EFX04473.1 - 0.0053 16.7 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain DUF1681 PF07933.14 EFX04474.1 - 1.6e-56 190.1 0.9 1e-55 187.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1681) SMN PF06003.12 EFX04474.1 - 0.24 10.6 4.8 0.4 9.9 4.8 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) IstB_IS21_ATP PF08483.11 EFX04474.1 - 1.5 8.8 4.8 7.5 6.6 1.5 2.6 2 0 0 2 2 2 0 IstB-like ATP binding N-terminal PRIMA1 PF16101.5 EFX04474.1 - 4.8 7.2 7.3 9.7 6.3 7.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EFX04474.1 - 5.1 6.5 16.1 15 4.9 13.5 2.5 2 1 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Amastin PF07344.11 EFX04475.1 - 0.00066 19.6 2.6 0.00066 19.6 2.6 2.2 1 1 1 2 2 2 1 Amastin surface glycoprotein NapE PF06796.11 EFX04475.1 - 0.21 11.1 0.1 0.21 11.1 0.1 2.5 3 0 0 3 3 3 0 Periplasmic nitrate reductase protein NapE UPF1_Zn_bind PF09416.10 EFX04476.1 - 5.5e-72 240.7 3.2 3.5e-71 238.1 0.8 2.4 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EFX04476.1 - 1.1e-60 204.6 0.0 5.2e-60 202.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFX04476.1 - 4.5e-53 180.7 2.9 6.9e-30 104.7 0.2 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EFX04476.1 - 6.5e-33 112.8 0.0 1.3e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EFX04476.1 - 4.6e-14 52.6 0.6 8.8e-12 45.1 0.6 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX04476.1 - 1.5e-10 41.6 0.4 8.3e-10 39.2 0.3 2.3 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EFX04476.1 - 5.5e-06 26.5 0.0 1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EFX04476.1 - 2.5e-05 24.2 0.0 4.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 EFX04476.1 - 4.6e-05 23.3 0.1 0.4 10.4 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EFX04476.1 - 0.00045 19.6 0.0 0.012 14.9 0.0 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 EFX04476.1 - 0.00085 18.6 0.2 0.4 9.8 0.0 2.3 1 1 0 2 2 2 2 PIF1-like helicase UvrD-helicase PF00580.21 EFX04476.1 - 0.0013 18.3 0.1 0.036 13.6 0.1 2.2 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 EFX04476.1 - 0.0024 17.7 0.1 0.0043 16.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.22 EFX04476.1 - 0.0044 16.7 0.0 0.0097 15.6 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ATPase PF06745.13 EFX04476.1 - 0.013 14.8 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 EFX04476.1 - 0.021 15.1 0.0 0.06 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 EFX04476.1 - 0.021 13.7 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain PhoH PF02562.16 EFX04476.1 - 0.1 12.0 0.0 0.31 10.5 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_5 PF07728.14 EFX04476.1 - 0.17 11.9 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FHA PF00498.26 EFX04477.1 - 4.3e-13 49.4 0.0 7.3e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 EFX04477.1 - 0.00057 20.1 0.1 0.0015 18.8 0.1 1.6 1 1 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFX04477.1 - 0.019 15.3 0.0 0.045 14.1 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DUF4588 PF15251.6 EFX04478.1 - 5.8e-12 45.9 1.3 5.8e-12 45.9 1.3 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4588) Abhydrolase_2 PF02230.16 EFX04479.1 - 4.9e-31 108.2 0.0 2.7e-23 82.9 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFX04479.1 - 1.4e-06 28.0 0.0 1.5e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 EFX04479.1 - 2.8e-05 23.8 0.0 4.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFX04479.1 - 0.00064 19.1 0.0 0.072 12.3 0.0 2.7 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFX04479.1 - 0.014 15.3 0.0 0.12 12.2 0.0 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Methyltransf_25 PF13649.6 EFX04480.1 - 6.6e-14 52.4 0.0 1.6e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04480.1 - 5.5e-11 43.0 0.0 1.8e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04480.1 - 1.3e-10 41.3 0.0 2.1e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX04480.1 - 7.3e-10 38.9 0.0 1.1e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04480.1 - 2.8e-09 37.6 0.0 6.8e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EFX04480.1 - 0.00052 20.2 0.0 0.00079 19.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EFX04480.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EFX04480.1 - 0.0013 18.7 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFX04480.1 - 0.034 13.9 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EFX04480.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_7 PF03492.15 EFX04480.1 - 0.19 10.9 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase HCO3_cotransp PF00955.21 EFX04482.1 - 1.2e-79 268.5 9.3 3.5e-46 158.1 1.7 3.0 1 1 1 2 2 2 2 HCO3- transporter family CTD_bind PF04818.13 EFX04483.1 - 1.1e-08 35.8 0.0 3.1e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. LMBR1 PF04791.16 EFX04485.1 - 2.4e-17 63.1 0.2 2.4e-17 63.1 0.2 2.4 2 1 1 3 3 3 2 LMBR1-like membrane protein CBFB_NFYA PF02045.15 EFX04486.1 - 3.8e-28 97.9 4.6 8.2e-28 96.8 4.6 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B UBA2_C PF16195.5 EFX04486.1 - 0.031 15.0 2.0 0.031 15.0 2.0 2.0 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus SprT-like PF10263.9 EFX04487.1 - 1.2e-36 125.0 0.3 2.1e-36 124.2 0.3 1.4 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 EFX04487.1 - 5.2e-08 32.7 5.2 1.1e-07 31.6 5.2 1.6 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 EFX04487.1 - 4.4e-06 27.0 0.2 4.4e-06 27.0 0.2 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFX04487.1 - 0.00011 22.7 0.1 0.00031 21.3 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain Zn-ribbon_8 PF09723.10 EFX04487.1 - 0.0075 16.4 1.7 0.018 15.2 1.7 1.6 1 0 0 1 1 1 1 Zinc ribbon domain CobT PF06213.12 EFX04487.1 - 0.092 12.1 17.2 0.28 10.6 17.2 1.8 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 EFX04487.1 - 0.097 12.0 20.8 0.21 10.9 20.8 1.6 1 0 0 1 1 1 0 NOA36 protein zf-C3HC4_3 PF13920.6 EFX04487.1 - 0.16 11.9 1.0 0.3 11.0 1.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Merozoite_SPAM PF07133.11 EFX04487.1 - 0.18 11.8 23.6 0.35 10.8 23.6 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop14 PF04147.12 EFX04487.1 - 0.2 9.8 22.2 0.37 8.9 22.2 1.4 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EFX04487.1 - 0.93 9.5 10.8 2.8 7.9 10.8 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal PPP4R2 PF09184.11 EFX04487.1 - 5.1 6.6 23.7 0.38 10.3 17.5 2.1 2 0 0 2 2 2 0 PPP4R2 Epimerase PF01370.21 EFX04488.1 - 0.003 17.0 0.0 0.031 13.7 0.0 2.4 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX04488.1 - 0.043 12.8 0.0 0.33 9.9 0.0 2.2 2 1 1 3 3 3 0 3-beta hydroxysteroid dehydrogenase/isomerase family Importin_rep_5 PF18816.1 EFX04488.1 - 0.1 12.9 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Importin repeat Glyco_hydro_3 PF00933.21 EFX04489.1 - 2.1e-41 142.4 0.0 3.4e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFX04489.1 - 5.1e-40 137.6 0.0 1.5e-39 136.1 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFX04489.1 - 6.1e-23 80.7 0.1 1.1e-22 79.8 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain 2OG-FeII_Oxy_3 PF13640.6 EFX04490.1 - 2.5e-07 31.5 0.0 1.9e-06 28.6 0.0 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily HSP70 PF00012.20 EFX04491.1 - 8.7e-07 27.5 0.0 0.0023 16.2 0.1 3.0 3 0 0 3 3 3 3 Hsp70 protein VHS PF00790.19 EFX04493.1 - 4.9e-44 149.6 0.0 1.4e-43 148.1 0.0 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EFX04493.1 - 4e-18 65.5 2.0 4.1e-18 65.5 0.2 2.0 2 0 0 2 2 2 1 GAT domain Alpha_adaptinC2 PF02883.20 EFX04493.1 - 5.5e-18 65.3 0.0 1e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EFX04493.1 - 1.7e-08 33.9 0.0 6.1e-08 32.2 0.0 1.9 1 0 0 1 1 1 1 GGA N-GAT domain DUF4322 PF14210.6 EFX04493.1 - 0.18 11.7 0.0 0.87 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4322) DUF3829 PF12889.7 EFX04493.1 - 0.5 9.8 3.2 0.76 9.2 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Cellulase PF00150.18 EFX04494.1 - 1.9e-16 60.3 0.0 2.4e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) cobW PF02492.19 EFX04495.1 - 3.3e-37 127.8 0.0 5.1e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EFX04495.1 - 0.00093 19.1 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B DUF463 PF04317.12 EFX04495.1 - 0.0092 15.0 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 YcjX-like family, DUF463 CobW_C PF07683.14 EFX04495.1 - 0.03 14.3 0.0 0.58 10.1 0.0 2.5 2 1 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 EFX04495.1 - 0.05 13.9 0.1 0.87 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EFX04495.1 - 0.092 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EFX04495.1 - 0.098 12.4 0.2 0.97 9.2 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 EFX04496.1 - 7.7e-26 91.2 0.0 3.4e-25 89.0 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 EFX04496.1 - 9.1e-06 26.2 0.1 0.00017 22.0 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EFX04496.1 - 0.00053 20.4 0.0 0.0023 18.4 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX04496.1 - 0.0018 18.5 0.1 0.0095 16.2 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFX04496.1 - 0.0069 16.1 0.1 0.015 15.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EFX04496.1 - 0.0071 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF853 PF05872.12 EFX04496.1 - 0.0088 14.7 1.6 0.029 13.0 0.1 2.1 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) NACHT PF05729.12 EFX04496.1 - 0.04 13.8 0.2 0.12 12.2 0.2 1.8 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EFX04496.1 - 0.043 14.3 0.0 0.099 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EFX04496.1 - 0.069 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EFX04496.1 - 0.075 13.4 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFX04496.1 - 0.089 13.0 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFX04496.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 EFX04496.1 - 0.12 12.5 0.0 0.47 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFX04496.1 - 0.18 11.8 0.0 0.38 10.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AMPK1_CBM PF16561.5 EFX04497.1 - 0.0021 18.2 0.0 0.0049 17.1 0.0 1.6 1 1 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_20 PF00686.19 EFX04497.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Starch binding domain LRRFIP PF09738.9 EFX04497.1 - 0.33 10.4 5.2 0.58 9.6 5.2 1.4 1 0 0 1 1 1 0 LRRFIP family EVI2A PF05399.11 EFX04497.1 - 0.9 9.1 5.9 1.6 8.3 5.9 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Macoilin PF09726.9 EFX04497.1 - 1.3 7.5 13.3 0.065 11.8 8.2 1.4 2 0 0 2 2 2 0 Macoilin family DUF4598 PF15370.6 EFX04497.1 - 5.3 7.5 6.5 38 4.8 3.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) Carb_anhydrase PF00194.21 EFX04499.1 - 6.6e-27 94.7 0.0 5.4e-13 49.1 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic-type carbonic anhydrase CAP_N PF01213.19 EFX04500.1 - 5.6e-120 400.6 0.3 7.5e-120 400.2 0.3 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EFX04500.1 - 4.4e-51 172.6 0.0 6.1e-51 172.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal DEC-1_N PF04625.13 EFX04500.1 - 3.4 6.6 24.8 0.31 10.0 7.5 2.3 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region Polysacc_deac_1 PF01522.21 EFX04501.1 - 3.5e-17 62.5 0.0 7.4e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EFX04501.1 - 0.0024 17.5 0.0 0.0061 16.2 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Methyltransf_16 PF10294.9 EFX04502.1 - 1.6e-10 41.0 0.0 5.1e-09 36.1 0.0 2.2 2 0 0 2 2 2 1 Lysine methyltransferase BRF1 PF07741.13 EFX04502.1 - 0.11 12.9 1.1 0.21 11.9 1.1 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Ammonium_transp PF00909.21 EFX04503.1 - 2e-116 389.0 32.8 2.3e-116 388.8 32.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF441 PF04284.13 EFX04503.1 - 0.036 14.1 0.5 0.13 12.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF441) Ribosomal_S13 PF00416.22 EFX04505.1 - 2.1e-18 67.0 0.5 1.6e-16 60.8 0.5 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 APH PF01636.23 EFX04506.1 - 5.7e-05 23.2 0.0 7.9e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family HEAT PF02985.22 EFX04507.1 - 2.2e-40 133.2 16.1 0.015 15.5 0.1 13.2 14 0 0 14 14 14 11 HEAT repeat HEAT_2 PF13646.6 EFX04507.1 - 7.2e-33 112.8 6.3 8.9e-11 42.0 0.0 8.2 3 3 5 8 8 8 8 HEAT repeats Vac14_Fab1_bd PF12755.7 EFX04507.1 - 7.7e-13 48.9 4.1 0.00084 19.9 0.1 7.8 4 3 5 9 9 9 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFX04507.1 - 3e-11 43.6 8.0 0.026 15.0 0.0 8.7 9 2 2 11 11 10 2 HEAT-like repeat Cnd1 PF12717.7 EFX04507.1 - 8.3e-11 42.2 9.4 0.00085 19.4 0.4 6.1 5 1 2 7 7 7 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EFX04507.1 - 7.3e-07 29.4 5.1 0.4 10.9 0.2 5.1 4 1 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 EFX04507.1 - 7.9e-06 24.7 9.6 0.014 14.0 0.4 5.4 3 2 0 5 5 5 1 Adaptin N terminal region CLASP_N PF12348.8 EFX04507.1 - 7.3e-05 22.4 2.3 0.019 14.5 0.1 4.3 3 3 0 4 4 4 1 CLASP N terminal RIX1 PF08167.12 EFX04507.1 - 0.05 13.4 0.0 7.6 6.2 0.0 2.9 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis TetR_C_16 PF17920.1 EFX04507.1 - 0.062 13.5 1.5 20 5.4 0.0 3.9 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Proteasom_PSMB PF10508.9 EFX04507.1 - 0.081 11.4 5.0 0.46 8.9 0.1 2.5 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit API5 PF05918.11 EFX04507.1 - 0.11 11.3 5.5 0.92 8.2 0.0 4.1 6 1 0 6 6 6 0 Apoptosis inhibitory protein 5 (API5) Arm PF00514.23 EFX04507.1 - 0.11 12.5 5.9 3.2 7.9 0.0 4.9 7 0 0 7 7 6 0 Armadillo/beta-catenin-like repeat Ecm29 PF13001.7 EFX04507.1 - 0.38 9.4 3.0 15 4.1 0.0 3.2 3 1 0 3 3 3 0 Proteasome stabiliser IFRD PF05004.13 EFX04507.1 - 0.52 9.4 1.8 1.8 7.6 0.2 3.0 3 1 0 3 3 3 0 Interferon-related developmental regulator (IFRD) ATP_bind_1 PF03029.17 EFX04508.1 - 6.3e-72 242.2 0.0 8e-70 235.4 0.0 2.0 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 EFX04508.1 - 0.0027 17.7 0.0 0.0056 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EFX04508.1 - 0.0027 17.5 0.0 0.0054 16.6 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_helicase PF00910.22 EFX04508.1 - 0.0055 17.1 0.0 0.014 15.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EFX04508.1 - 0.0059 17.1 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFX04508.1 - 0.0094 15.7 0.2 0.035 13.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_24 PF13479.6 EFX04508.1 - 0.03 14.0 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFX04508.1 - 0.047 13.8 0.0 0.081 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFX04508.1 - 0.065 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EFX04508.1 - 0.066 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_16 PF13191.6 EFX04508.1 - 0.076 13.4 0.0 0.21 12.0 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFX04508.1 - 0.083 12.8 0.1 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EFX04508.1 - 0.092 13.3 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 EFX04508.1 - 0.11 12.1 0.0 2.7 7.5 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRP54 PF00448.22 EFX04508.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EFX04508.1 - 0.15 12.2 0.0 0.43 10.7 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Cytidylate_kin PF02224.18 EFX04508.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase HAD_2 PF13419.6 EFX04510.1 - 0.00072 19.7 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX04510.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 HAD-hyrolase-like Pkr1 PF08636.10 EFX04511.1 - 3.8e-31 107.0 7.0 5.3e-31 106.6 7.0 1.2 1 0 0 1 1 1 1 ER protein Pkr1 LSM PF01423.22 EFX04511.1 - 8.3e-17 60.6 0.0 1.3e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFX04511.1 - 0.0054 16.8 0.0 0.0099 16.0 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain Pdase_C33_assoc PF14756.6 EFX04511.1 - 0.025 14.5 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase_C33-associated domain TMCO5 PF14992.6 EFX04511.1 - 0.53 9.8 0.0 0.53 9.8 0.0 1.7 2 0 0 2 2 2 0 TMCO5 family SelK_SelG PF10961.8 EFX04511.1 - 3.9 8.2 12.2 0.17 12.6 5.3 2.3 2 1 0 2 2 2 0 Selenoprotein SelK_SelG Phage_Gp23 PF10669.9 EFX04511.1 - 5.1 7.4 5.8 18 5.7 2.7 2.8 2 1 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Dioxygenase_C PF00775.21 EFX04512.1 - 1.7e-10 40.6 0.0 3.9e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Dioxygenase Cyt-b5 PF00173.28 EFX04513.1 - 1.1e-12 47.8 0.1 1.4e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-B_box PF00643.24 EFX04514.1 - 0.015 15.5 0.3 0.022 14.9 0.3 1.3 1 0 0 1 1 1 0 B-box zinc finger zf-HIT PF04438.16 EFX04514.1 - 0.99 9.3 4.7 1.5 8.8 4.7 1.2 1 0 0 1 1 1 0 HIT zinc finger SPX PF03105.19 EFX04514.1 - 9.6 6.0 7.3 11 5.8 7.3 1.2 1 0 0 1 1 1 0 SPX domain SUN PF03856.13 EFX04515.1 - 3.7e-76 255.8 9.4 5.1e-76 255.4 9.4 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) CDC27 PF09507.10 EFX04516.1 - 1.4e-48 166.4 21.5 4e-48 164.9 21.5 1.7 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 CDC45 PF02724.14 EFX04516.1 - 8.9 4.5 8.9 13 3.9 8.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L26 PF16906.5 EFX04517.1 - 2.5e-39 133.6 2.8 3.4e-39 133.2 2.8 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EFX04517.1 - 8.3e-07 28.8 1.2 1.8e-06 27.7 1.2 1.6 1 0 0 1 1 1 1 KOW motif DUF1442 PF07279.11 EFX04517.1 - 0.09 12.1 0.3 0.12 11.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) RRM_1 PF00076.22 EFX04518.1 - 2.5e-20 72.1 0.0 6.6e-11 41.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 EFX04518.1 - 0.05 13.6 0.0 0.98 9.5 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain MAM33 PF02330.16 EFX04520.1 - 3.2e-69 233.1 0.3 4.9e-69 232.5 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein RIC1 PF07064.13 EFX04522.1 - 4.8e-92 307.9 0.0 6.7e-92 307.4 0.0 1.2 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 EFX04522.1 - 0.0086 16.4 0.0 7.5 6.9 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFX04522.1 - 0.11 13.4 0.1 37 5.4 0.0 4.4 4 0 0 4 4 4 0 WD domain, G-beta repeat ENTH PF01417.20 EFX04523.1 - 8.5e-46 155.1 0.0 1.3e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EFX04523.1 - 0.00042 19.4 0.0 0.00058 18.9 0.0 1.1 1 0 0 1 1 1 1 ANTH domain Cwf_Cwc_15 PF04889.12 EFX04524.1 - 0.00054 19.8 2.3 0.00083 19.2 2.3 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EFX04524.1 - 0.84 8.9 5.7 1.3 8.3 5.7 1.2 1 0 0 1 1 1 0 NOA36 protein Collagen PF01391.18 EFX04525.1 - 8.8e-22 76.6 190.4 3.6e-08 33.1 23.1 10.7 3 3 5 8 8 8 5 Collagen triple helix repeat (20 copies) Toxin_17 PF08086.11 EFX04525.1 - 0.035 14.4 0.2 0.14 12.5 0.2 2.1 1 0 0 1 1 1 0 Ergtoxin family Fungal_trans_2 PF11951.8 EFX04526.1 - 1e-44 152.9 0.2 1.6e-44 152.3 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ring_hydroxyl_A PF00848.19 EFX04526.1 - 1.1e-21 77.8 0.5 4.6e-11 43.1 0.0 2.6 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) Zn_clus PF00172.18 EFX04526.1 - 1e-06 28.7 10.9 1.9e-06 27.9 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OPT PF03169.15 EFX04527.1 - 8.9e-128 427.6 37.5 1e-127 427.4 37.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ThrE PF06738.12 EFX04527.1 - 1.3 8.4 4.9 0.29 10.5 1.0 1.9 2 0 0 2 2 2 0 Putative threonine/serine exporter DUF3984 PF13136.6 EFX04528.1 - 3.3 7.0 13.7 0.38 10.1 5.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) EI24 PF07264.11 EFX04529.1 - 1.7e-08 34.9 18.0 4.8e-08 33.5 18.0 1.7 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) SLATT_1 PF18181.1 EFX04529.1 - 0.065 13.2 0.3 0.15 12.0 0.3 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Tcp11 PF05794.13 EFX04530.1 - 9.9e-106 354.5 0.0 9.9e-106 354.5 0.0 2.4 2 1 0 2 2 2 1 T-complex protein 11 TFIIA PF03153.13 EFX04530.1 - 0.29 11.1 31.9 0.022 14.8 26.1 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Baculo_PP31 PF05311.11 EFX04530.1 - 2.3 7.6 8.4 3.9 6.9 8.4 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Hydin_ADK PF17213.3 EFX04530.1 - 5.3 7.3 10.2 12 6.1 10.2 1.7 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PAT1 PF09770.9 EFX04530.1 - 9.8 4.3 24.9 14 3.7 24.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SNF2_N PF00176.23 EFX04531.1 - 2.3e-50 171.3 0.3 2.3e-49 168.0 0.3 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX04531.1 - 8.1e-17 61.6 0.0 6.1e-16 58.7 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX04531.1 - 2e-08 34.4 0.1 6.6e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EFX04531.1 - 7.4e-05 22.5 14.4 7.4e-05 22.5 14.4 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFX04531.1 - 0.00061 19.6 12.1 0.00061 19.6 12.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 EFX04531.1 - 0.001 18.8 0.1 0.0024 17.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_2 PF13639.6 EFX04531.1 - 0.0026 18.0 14.0 0.0026 18.0 14.0 2.7 2 0 0 2 2 2 1 Ring finger domain ERCC3_RAD25_C PF16203.5 EFX04531.1 - 0.018 14.3 0.0 0.039 13.2 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_34 PF13872.6 EFX04531.1 - 0.13 11.1 0.0 0.3 9.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 zf-C3HC4_2 PF13923.6 EFX04531.1 - 0.29 11.0 19.7 0.016 15.0 13.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.6 EFX04531.1 - 3.7 7.7 13.8 6.9 6.8 3.3 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain tRNA-synt_1 PF00133.22 EFX04532.1 - 1.4e-41 142.4 0.0 2.6e-24 85.4 0.0 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EFX04532.1 - 1e-40 139.3 0.0 1.8e-40 138.4 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EFX04532.1 - 2.4e-27 95.7 0.0 2.6e-21 75.8 0.0 4.3 3 1 1 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFX04532.1 - 2.6e-13 50.2 0.0 5.2e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFX04532.1 - 0.16 11.2 0.0 9.7 5.4 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain Sulf_transp PF04143.14 EFX04533.1 - 1.3e-28 100.5 26.6 1.3e-28 100.5 26.6 1.3 2 0 0 2 2 2 1 Sulphur transport MCM PF00493.23 EFX04534.1 - 4.4e-51 173.1 0.0 6e-39 133.4 0.0 2.3 1 1 1 2 2 2 2 MCM P-loop domain MCM_OB PF17207.3 EFX04534.1 - 1.8e-39 134.5 0.8 3e-39 133.8 0.8 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFX04534.1 - 7.2e-27 93.7 3.2 1.7e-26 92.4 3.2 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFX04534.1 - 3.1e-18 66.3 0.0 7.6e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Oberon_cc PF16312.5 EFX04534.1 - 0.35 10.8 2.7 0.74 9.8 2.7 1.5 1 0 0 1 1 1 0 Coiled-coil region of Oberon Elf1 PF05129.13 EFX04534.1 - 1.2 9.3 2.6 1.1 9.4 1.1 1.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Serinc PF03348.15 EFX04535.1 - 3.7e-160 533.5 7.4 4.2e-160 533.4 7.4 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) FTR1 PF03239.14 EFX04535.1 - 6.8 5.8 13.2 0.93 8.6 8.6 1.8 2 0 0 2 2 2 0 Iron permease FTR1 family Methyltransf_23 PF13489.6 EFX04536.1 - 2e-21 76.5 0.0 2.6e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04536.1 - 1.5e-15 57.6 0.0 7.7e-15 55.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04536.1 - 2e-15 57.3 0.0 1.7e-14 54.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04536.1 - 1.4e-13 51.4 0.0 2.4e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04536.1 - 1.7e-12 47.4 0.0 4.6e-12 46.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04536.1 - 1.4e-06 27.9 0.0 2.3e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 EFX04536.1 - 1.4e-05 24.8 0.0 0.00022 20.9 0.1 2.0 2 0 0 2 2 2 1 Nodulation protein S (NodS) DREV PF05219.12 EFX04536.1 - 0.00026 20.2 0.0 0.027 13.6 0.0 2.1 2 0 0 2 2 2 1 DREV methyltransferase RrnaAD PF00398.20 EFX04536.1 - 0.0034 16.5 0.0 0.0049 16.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 EFX04536.1 - 0.0042 16.6 0.0 0.2 11.1 0.0 2.4 2 1 0 2 2 2 1 Putative methyltransferase PCMT PF01135.19 EFX04536.1 - 0.0046 16.7 0.0 0.0084 15.9 0.0 1.4 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 EFX04536.1 - 0.011 15.4 0.0 0.03 14.1 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase MTS PF05175.14 EFX04536.1 - 0.02 14.4 0.1 0.039 13.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain tRNA_U5-meth_tr PF05958.11 EFX04536.1 - 0.041 12.9 0.0 0.056 12.4 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_32 PF13679.6 EFX04536.1 - 0.053 13.5 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 EFX04536.1 - 0.077 11.9 0.0 0.44 9.4 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) Pox_MCEL PF03291.16 EFX04536.1 - 0.1 11.7 0.0 0.21 10.6 0.0 1.4 1 1 0 1 1 1 0 mRNA capping enzyme DUF938 PF06080.12 EFX04536.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Tannase PF07519.11 EFX04537.1 - 4.6e-91 306.1 0.0 5.9e-91 305.7 0.0 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Esterase PF00756.20 EFX04537.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase zn-ribbon_14 PF16503.5 EFX04538.1 - 4.2e-19 67.7 2.9 4.2e-19 67.7 2.9 2.8 3 0 0 3 3 3 1 Zinc-ribbon ATP_bind_3 PF01171.20 EFX04538.1 - 4e-18 65.8 0.0 6.8e-18 65.1 0.0 1.4 1 1 0 1 1 1 1 PP-loop family RecR PF02132.15 EFX04538.1 - 0.0075 15.8 2.5 0.0083 15.7 0.4 2.1 2 0 0 2 2 2 1 RecR protein tRNA_Me_trans PF03054.16 EFX04538.1 - 0.014 14.2 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase CoA_transf_3 PF02515.17 EFX04539.1 - 1.8e-44 152.4 0.0 2.6e-43 148.6 0.0 2.1 2 0 0 2 2 2 2 CoA-transferase family III Maf1 PF09174.10 EFX04540.1 - 1e-59 201.6 0.0 1.4e-59 201.1 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator SURF2 PF05477.11 EFX04540.1 - 0.11 12.1 3.9 0.18 11.5 3.9 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SDA1 PF05285.12 EFX04540.1 - 4.4 6.6 9.6 6.8 6.0 9.2 1.5 2 0 0 2 2 2 0 SDA1 adh_short PF00106.25 EFX04541.1 - 4.8e-19 68.6 0.3 1.1e-18 67.5 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04541.1 - 1.8e-16 60.4 0.1 3.8e-16 59.4 0.1 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX04541.1 - 0.025 14.5 0.1 0.24 11.3 0.1 2.4 1 1 1 2 2 2 0 KR domain Kinesin PF00225.23 EFX04542.1 - 2.5e-113 378.4 0.0 3.5e-113 377.9 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFX04542.1 - 1.2e-25 90.2 0.0 2.4e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Herpes_UL14 PF03580.14 EFX04542.1 - 0.017 15.3 4.4 0.04 14.2 4.4 1.5 1 0 0 1 1 1 0 Herpesvirus UL14-like protein AAA_33 PF13671.6 EFX04542.1 - 0.043 14.0 0.0 0.2 11.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain Gly_transf_sug PF04488.15 EFX04543.1 - 1.8e-14 54.2 0.0 4.5e-14 52.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EFX04543.1 - 0.06 12.6 0.1 0.14 11.5 0.1 1.5 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 EFX04543.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Glyco_hydro_3_C PF01915.22 EFX04545.1 - 1.5e-44 152.4 0.0 3.7e-44 151.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX04545.1 - 4.3e-25 88.8 0.0 1.5e-16 60.7 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX04545.1 - 2.3e-20 72.5 0.1 4.4e-20 71.6 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Aldedh PF00171.22 EFX04546.1 - 1.2e-136 455.9 0.8 1.7e-136 455.4 0.8 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Glyco_hydro_16 PF00722.21 EFX04547.1 - 5.8e-07 29.1 1.0 4e-06 26.4 1.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Metallophos PF00149.28 EFX04548.1 - 2.5e-07 31.4 0.0 3.7e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFX04548.1 - 3.8e-07 30.4 0.3 5.4e-06 26.7 0.3 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Transp_inhibit PF18791.1 EFX04548.1 - 0.0041 16.6 0.2 0.027 14.0 0.0 2.2 2 0 0 2 2 2 1 Transport inhibitor response 1 protein domain Metallophos_3 PF14582.6 EFX04548.1 - 0.049 13.0 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily PLDc_2 PF13091.6 EFX04549.1 - 8.4e-14 51.6 0.0 7.5e-06 25.9 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFX04549.1 - 1.1e-07 31.7 2.5 0.013 15.6 0.1 3.4 2 1 0 2 2 2 2 Phospholipase D Active site motif ENTH PF01417.20 EFX04550.1 - 2.2e-48 163.5 0.0 3.6e-48 162.7 0.0 1.4 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 EFX04550.1 - 0.00033 21.0 35.1 0.00033 21.0 35.1 4.7 1 1 2 3 3 3 1 Domain of unknown function (DUF1720) UIM PF02809.20 EFX04550.1 - 0.00095 18.9 2.0 0.091 12.7 0.2 3.0 2 0 0 2 2 2 1 Ubiquitin interaction motif ANTH PF07651.16 EFX04550.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 ANTH domain AIDA PF16168.5 EFX04550.1 - 0.016 15.3 0.1 0.034 14.2 0.1 1.5 1 0 0 1 1 1 0 Adhesin of bacterial autotransporter system, probable stalk VHS PF00790.19 EFX04550.1 - 0.024 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 VHS domain CDC45 PF02724.14 EFX04550.1 - 0.2 9.9 5.4 0.25 9.6 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein BBP1_N PF15271.6 EFX04550.1 - 0.26 12.1 9.0 0.11 13.3 4.7 2.2 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein SUIM_assoc PF16619.5 EFX04550.1 - 2.9 8.0 18.7 12 6.0 0.0 4.5 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 ACT_7 PF13840.6 EFX04551.1 - 3e-21 75.0 0.2 4.3e-15 55.2 0.0 2.4 2 0 0 2 2 2 2 ACT domain LpxD PF04613.14 EFX04551.1 - 0.054 13.3 0.0 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD adh_short PF00106.25 EFX04552.1 - 1.9e-24 86.2 0.0 2.6e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04552.1 - 2.4e-20 73.1 0.0 3e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX04552.1 - 0.00049 20.1 0.0 0.0011 18.9 0.0 1.5 2 0 0 2 2 2 1 KR domain DUF460 PF04312.13 EFX04552.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF460) ATE_C PF04377.15 EFX04553.1 - 9.4e-46 155.8 0.1 1.5e-45 155.1 0.1 1.3 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EFX04553.1 - 0.0005 20.4 0.3 0.0012 19.1 0.3 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 EFX04553.1 - 0.071 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NOA36 PF06524.12 EFX04553.1 - 0.5 9.6 3.5 0.8 9.0 3.5 1.2 1 0 0 1 1 1 0 NOA36 protein GATA PF00320.27 EFX04554.1 - 0.0013 18.3 5.6 0.062 12.9 2.4 2.6 2 0 0 2 2 2 2 GATA zinc finger Svf1_C PF17187.4 EFX04556.1 - 3.7e-62 209.0 0.0 7.6e-62 208.0 0.0 1.5 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EFX04556.1 - 5.6e-55 185.9 0.0 8.1e-55 185.3 0.0 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain SRR PF07709.11 EFX04557.1 - 0.14 12.6 0.1 0.35 11.4 0.1 1.7 1 0 0 1 1 1 0 Seven Residue Repeat Sugar_tr PF00083.24 EFX04559.1 - 1.9e-111 373.1 22.8 2.4e-111 372.8 22.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04559.1 - 1.8e-18 66.6 43.5 2.5e-12 46.4 13.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SNF2_N PF00176.23 EFX04560.1 - 0.00034 19.4 0.0 0.00058 18.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Sugar_tr PF00083.24 EFX04561.1 - 1.1e-60 205.8 8.4 1.5e-60 205.4 8.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04561.1 - 7.3e-17 61.3 18.4 9e-17 61.0 18.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1616 PF07760.11 EFX04561.1 - 0.066 12.6 1.2 0.12 11.7 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) SUI1 PF01253.22 EFX04562.1 - 3.6e-26 91.5 0.4 9.4e-26 90.2 0.4 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 EFX04562.1 - 0.03 14.6 0.1 0.089 13.1 0.1 1.8 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) TPR_12 PF13424.6 EFX04566.1 - 7.1e-10 39.1 3.2 0.0019 18.4 0.2 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFX04566.1 - 1.7e-06 27.6 2.2 0.15 12.2 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX04566.1 - 0.00014 21.6 2.8 0.14 12.0 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX04566.1 - 0.0038 17.2 8.7 1.8 8.9 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFX04566.1 - 0.043 14.4 0.1 0.043 14.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX04566.1 - 0.045 14.0 2.7 27 5.3 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFX04566.1 - 0.26 11.2 2.9 37 4.4 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DASH_Dad4 PF08650.10 EFX04567.1 - 1.2e-28 98.8 5.2 2e-28 98.1 5.2 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad4 GST_N_4 PF17172.4 EFX04567.1 - 3.7e-19 69.3 0.0 1.6e-18 67.3 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EFX04567.1 - 4.6e-08 33.4 0.0 1.1e-07 32.2 0.0 1.7 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EFX04567.1 - 1.2e-07 31.4 0.1 2.6e-06 27.1 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFX04567.1 - 0.0017 18.3 0.3 0.0039 17.2 0.3 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SAM35 PF10806.8 EFX04567.1 - 0.098 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex Tctex-1 PF03645.13 EFX04569.1 - 9.3e-40 135.0 0.0 1.1e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family TauD PF02668.16 EFX04570.1 - 4.3e-28 98.8 0.1 1.1e-27 97.5 0.1 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ribosomal_S3_C PF00189.20 EFX04571.1 - 1.1e-24 86.8 0.2 5.6e-24 84.5 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EFX04571.1 - 6.5e-12 45.1 0.1 1.2e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 EFX04571.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 EFX04571.1 - 0.13 12.1 0.3 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Coilin N-terminus Mito_carr PF00153.27 EFX04572.1 - 4.5e-58 193.2 1.2 1.3e-24 85.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Nop PF01798.18 EFX04573.1 - 3.1e-69 232.9 0.0 4.3e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EFX04573.1 - 6.9e-44 149.6 0.5 1.6e-43 148.5 0.5 1.7 1 0 0 1 1 1 1 Prp31 C terminal domain RRN3 PF05327.11 EFX04573.1 - 1.6 7.1 3.7 2.4 6.6 3.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AMPK1_CBM PF16561.5 EFX04574.1 - 2e-15 56.8 0.3 1.5e-07 31.5 0.0 2.5 2 0 0 2 2 2 2 Glycogen recognition site of AMP-activated protein kinase PT PF04886.12 EFX04574.1 - 0.84 9.2 12.2 0.031 13.8 3.1 3.5 2 1 0 2 2 2 0 PT repeat UEV PF05743.13 EFX04575.1 - 1.3e-37 128.3 0.0 1.8e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 UEV domain UQ_con PF00179.26 EFX04575.1 - 0.016 14.8 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme RNA_polI_A34 PF08208.11 EFX04575.1 - 2.7 8.1 6.1 0.31 11.1 1.6 1.6 1 1 1 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 ADH_N PF08240.12 EFX04577.1 - 1e-27 96.2 2.7 1.7e-27 95.4 2.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX04577.1 - 1.2e-14 54.4 0.5 1.3e-13 51.0 0.2 2.2 1 1 1 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX04577.1 - 7.8e-05 23.7 0.0 0.00017 22.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 EFX04577.1 - 0.012 15.8 0.1 0.022 15.0 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EFX04577.1 - 0.014 14.7 0.3 0.03 13.6 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TPK_catalytic PF04263.16 EFX04578.1 - 1.9e-30 105.4 0.0 2.7e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EFX04578.1 - 2.1e-24 85.0 0.0 3.2e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TRAPPC9-Trs120 PF08626.11 EFX04579.1 - 0 1273.1 0.0 0 1266.7 0.0 2.0 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Abhydrolase_3 PF07859.13 EFX04579.1 - 2e-42 145.4 0.0 1.8e-41 142.3 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 EFX04579.1 - 1.6e-05 24.0 0.1 3.6e-05 22.9 0.1 1.4 1 1 0 1 1 1 1 Carboxylesterase family TFIIF_beta_N PF17683.1 EFX04580.1 - 2.4e-34 118.9 0.1 6.4e-34 117.6 0.1 1.7 2 0 0 2 2 2 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EFX04580.1 - 1.1e-28 99.2 0.1 1.7e-28 98.5 0.1 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Amidohydro_2 PF04909.14 EFX04581.1 - 5.7e-11 42.7 0.0 2e-10 41.0 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 EFX04581.1 - 6.5e-06 25.7 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family CoA_binding_2 PF13380.6 EFX04581.1 - 0.0098 16.4 0.0 0.055 14.0 0.0 2.2 2 1 0 2 2 2 1 CoA binding domain COQ7 PF03232.13 EFX04582.1 - 5.5e-72 241.1 0.1 6.3e-72 240.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EFX04582.1 - 0.0028 18.1 0.3 0.0046 17.4 0.0 1.6 2 0 0 2 2 2 1 Rubrerythrin Ferritin_2 PF13668.6 EFX04582.1 - 0.12 12.6 0.2 0.24 11.6 0.0 1.7 2 1 0 2 2 2 0 Ferritin-like domain CBP4 PF07960.11 EFX04582.1 - 0.14 12.0 0.0 1.4 8.8 0.0 2.0 2 0 0 2 2 2 0 CBP4 Beta-lactamase PF00144.24 EFX04583.1 - 4.1e-28 98.6 4.7 2.5e-19 69.7 0.2 2.6 2 1 0 2 2 2 2 Beta-lactamase Beta-lactamase2 PF13354.6 EFX04583.1 - 0.028 14.0 0.3 0.19 11.3 0.1 2.0 1 1 1 2 2 2 0 Beta-lactamase enzyme family CDT1_C PF16679.5 EFX04584.1 - 1.3e-23 83.2 0.8 1.3e-23 83.2 0.8 3.3 3 0 0 3 3 3 1 DNA replication factor Cdt1 C-terminal domain YfcL PF08891.11 EFX04584.1 - 0.015 15.6 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 YfcL protein Cut8 PF08559.10 EFX04584.1 - 1.3 8.6 6.4 19 4.8 0.0 2.4 2 0 0 2 2 2 0 Cut8, nuclear proteasome tether protein DNA_pol_A_exo1 PF01612.20 EFX04585.1 - 2.8e-11 43.4 0.0 4e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Glyco_hydro_3_C PF01915.22 EFX04586.1 - 3.1e-50 171.0 0.1 4.6e-50 170.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX04586.1 - 4.1e-36 125.0 0.0 8.6e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX04586.1 - 3e-22 78.5 0.0 5.6e-22 77.6 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Suf PF05843.14 EFX04587.1 - 2.6e-10 40.8 4.7 0.1 12.6 0.0 6.3 4 1 3 7 7 7 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EFX04587.1 - 4.3e-07 30.2 47.1 0.37 11.7 0.0 12.6 13 3 2 15 15 15 5 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFX04587.1 - 6.8e-06 26.1 12.1 0.2 11.6 0.0 7.2 7 1 2 9 9 9 3 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 EFX04587.1 - 2.6e-05 24.1 0.2 6 7.3 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFX04587.1 - 0.0011 19.5 12.1 4.8 7.8 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EFX04587.1 - 0.0028 16.8 9.7 0.14 11.3 0.1 5.8 3 3 1 5 5 5 1 NRDE-2, necessary for RNA interference TPR_2 PF07719.17 EFX04587.1 - 0.0097 16.0 14.2 1.3 9.3 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFX04587.1 - 0.28 11.3 5.0 25 5.2 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFX04587.1 - 1.1 10.0 4.7 63 4.5 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Amidase PF01425.21 EFX04588.1 - 1e-88 298.3 0.9 1.3e-71 241.9 1.2 2.7 2 1 0 2 2 2 2 Amidase NB-ARC PF00931.22 EFX04588.1 - 0.06 12.5 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain MOZ_SAS PF01853.18 EFX04589.1 - 3.4e-76 254.9 0.1 4.8e-76 254.4 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFX04589.1 - 2.3e-20 72.0 3.0 4.4e-20 71.0 3.0 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 EFX04589.1 - 3e-07 30.4 7.3 1e-06 28.7 7.3 2.0 1 0 0 1 1 1 1 PHD-finger PHD PF00628.29 EFX04589.1 - 0.011 15.6 9.3 0.011 15.6 9.3 2.2 2 0 0 2 2 2 0 PHD-finger Acetyltransf_7 PF13508.7 EFX04589.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-HC5HC2H_2 PF13832.6 EFX04589.1 - 0.27 11.4 2.5 0.57 10.4 2.5 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain OrfB_Zn_ribbon PF07282.11 EFX04589.1 - 5.3 7.0 6.5 94 3.0 0.0 2.8 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Complex1_49kDa PF00346.19 EFX04590.1 - 1.8e-123 411.0 0.0 2.5e-123 410.5 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EFX04590.1 - 0.0035 16.3 0.0 0.0074 15.2 0.0 1.5 1 1 0 1 1 1 1 Nickel-dependent hydrogenase adh_short PF00106.25 EFX04591.1 - 2.8e-36 124.8 0.0 3.8e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04591.1 - 1.7e-29 103.0 0.0 2.3e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EFX04591.1 - 0.001 19.0 0.1 0.002 18.1 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EFX04591.1 - 0.031 13.7 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 EFX04591.1 - 0.069 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 EFX04591.1 - 0.11 12.8 0.1 1.1 9.6 0.1 2.2 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Sugar_tr PF00083.24 EFX04592.1 - 2.9e-27 95.7 23.5 8.9e-17 61.1 13.6 4.7 1 1 1 2 2 2 2 Sugar (and other) transporter OppC_N PF12911.7 EFX04592.1 - 0.3 11.1 2.3 38 4.3 0.0 4.0 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C Fructosamin_kin PF03881.14 EFX04593.1 - 4.5e-72 242.7 0.0 5.3e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EFX04593.1 - 0.00085 19.3 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YEATS PF03366.16 EFX04594.1 - 1.1e-30 105.5 0.1 1.5e-30 104.9 0.1 1.2 1 0 0 1 1 1 1 YEATS family GDA1_CD39 PF01150.17 EFX04595.1 - 3.6e-103 345.5 0.0 5.3e-103 344.9 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family EMP24_GP25L PF01105.24 EFX04596.1 - 1.3e-45 155.5 1.5 1.5e-45 155.3 1.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Fungal_trans_2 PF11951.8 EFX04598.1 - 0.00064 18.6 0.2 0.00089 18.2 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aldose_epim PF01263.20 EFX04599.1 - 7.3e-39 133.9 0.0 3.2e-37 128.5 0.0 2.0 1 1 0 1 1 1 1 Aldose 1-epimerase Ank_2 PF12796.7 EFX04600.1 - 1.4e-44 150.6 2.8 6.7e-08 33.0 0.0 8.4 4 3 4 8 8 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX04600.1 - 4.5e-32 110.0 17.2 3.6e-06 27.4 0.4 10.6 4 3 5 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX04600.1 - 2e-27 92.2 14.4 0.13 12.9 0.0 14.1 14 0 0 14 14 13 5 Ankyrin repeat Ank_5 PF13857.6 EFX04600.1 - 1.5e-25 88.9 12.3 0.00026 21.2 0.0 9.1 6 2 4 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.30 EFX04600.1 - 5.3e-15 55.1 14.3 0.11 12.9 0.0 13.7 16 0 0 16 16 13 2 Ankyrin repeat DUF676 PF05057.14 EFX04600.1 - 2e-10 40.6 0.0 2.3e-07 30.6 0.0 2.3 2 0 0 2 2 2 2 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFX04600.1 - 6.4e-09 35.9 0.0 0.0017 18.1 0.0 3.5 3 0 0 3 3 3 2 PGAP1-like protein NACHT PF05729.12 EFX04600.1 - 5.3e-06 26.4 0.0 1.3e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFX04600.1 - 2.4e-05 24.6 0.0 0.00011 22.4 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX04600.1 - 0.00013 22.4 0.1 0.00056 20.3 0.1 2.1 1 0 0 1 1 1 1 AAA ATPase domain Abhydrolase_6 PF12697.7 EFX04600.1 - 0.00013 22.7 0.0 0.0033 18.0 0.0 2.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family NB-ARC PF00931.22 EFX04600.1 - 0.01 15.1 0.0 0.034 13.3 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EFX04600.1 - 0.015 15.2 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EFX04600.1 - 0.024 15.0 0.0 0.13 12.6 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 EFX04600.1 - 0.026 14.9 0.0 0.068 13.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EFX04600.1 - 0.033 14.5 0.0 0.093 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFX04600.1 - 0.048 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Cutinase PF01083.22 EFX04600.1 - 0.068 13.1 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 Cutinase TsaE PF02367.17 EFX04600.1 - 0.074 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EFX04600.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFX04600.1 - 0.12 12.1 0.0 0.39 10.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Lectin_leg-like PF03388.13 EFX04601.1 - 5.3e-22 78.3 0.0 7.8e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family ABC_tran_CTD PF16326.5 EFX04601.1 - 0.0068 16.6 0.6 4.8 7.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 EFX04601.1 - 0.015 15.3 0.4 0.029 14.4 0.4 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG5 PF10392.9 EFX04601.1 - 0.031 14.4 0.6 0.058 13.6 0.6 1.4 1 0 0 1 1 1 0 Golgi transport complex subunit 5 LysM PF01476.20 EFX04602.1 - 7.1e-08 32.4 0.0 1.1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 LysM domain Rad52_Rad22 PF04098.15 EFX04603.1 - 4.2e-60 202.1 0.0 5.8e-60 201.7 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Mito_carr PF00153.27 EFX04604.1 - 5e-52 173.8 3.2 1.8e-18 66.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SecE PF00584.20 EFX04604.1 - 0.067 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex IBR PF01485.21 EFX04605.1 - 6e-24 84.0 48.3 1.6e-12 47.5 7.6 4.5 3 1 1 4 4 4 4 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFX04605.1 - 0.00016 21.4 5.3 0.00016 21.4 5.3 4.5 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFX04605.1 - 0.0011 19.2 6.5 0.0011 19.2 6.5 4.2 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFX04605.1 - 0.0039 17.0 4.5 0.0039 17.0 4.5 5.0 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFX04605.1 - 0.046 13.9 0.6 0.046 13.9 0.6 4.5 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Trp_syntA PF00290.20 EFX04605.1 - 0.22 10.3 0.0 0.34 9.7 0.0 1.1 1 0 0 1 1 1 0 Tryptophan synthase alpha chain NAD_binding_8 PF13450.6 EFX04606.1 - 1.5e-09 37.9 0.0 1.3e-08 35.0 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 EFX04606.1 - 1.6e-06 26.9 0.0 4.9e-05 22.0 0.0 2.6 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX04606.1 - 0.0021 17.4 0.0 0.011 15.0 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX04606.1 - 0.0038 16.4 0.0 1.6 7.8 0.0 3.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFX04606.1 - 0.0069 16.4 0.3 0.2 11.7 0.0 2.9 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFX04606.1 - 0.007 15.6 0.0 0.25 10.5 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ribonuc_L-PSP PF01042.21 EFX04607.1 - 2.1e-21 76.2 0.0 2.4e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP PEX11 PF05648.14 EFX04608.1 - 1.9e-58 197.6 0.3 2.1e-58 197.4 0.3 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) zf-C3HC4_3 PF13920.6 EFX04609.1 - 4.9e-09 35.9 12.0 8.1e-09 35.2 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX04609.1 - 0.055 13.3 12.4 0.09 12.6 12.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Aldedh PF00171.22 EFX04610.1 - 1.2e-156 521.8 1.2 1.4e-156 521.6 1.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SUIM_assoc PF16619.5 EFX04612.1 - 0.00016 21.7 13.5 0.016 15.3 2.9 3.3 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 EFX04612.1 - 1.7 8.2 14.1 4.5 6.8 0.8 2.4 2 0 0 2 2 2 0 Spt20 family Roughex PF06020.11 EFX04612.1 - 3.8 6.5 6.8 1.4 7.9 0.8 2.3 2 0 0 2 2 2 0 Drosophila roughex protein WSC PF01822.19 EFX04613.1 - 2.1e-19 69.5 2.9 4e-19 68.6 2.9 1.5 1 0 0 1 1 1 1 WSC domain 2Fe-2S_thioredx PF01257.19 EFX04614.1 - 1.2e-58 197.0 0.1 1.6e-58 196.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Peptidase_M24 PF00557.24 EFX04615.1 - 3e-42 144.7 0.1 3.8e-42 144.3 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3323 PF11796.8 EFX04615.1 - 0.038 13.9 0.2 0.065 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) NST1 PF13945.6 EFX04615.1 - 0.13 12.3 3.0 0.21 11.7 3.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Med3 PF11593.8 EFX04615.1 - 0.4 9.8 5.1 0.53 9.4 5.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PGA2 PF07543.12 EFX04615.1 - 7.3 6.6 7.3 2.1 8.3 3.7 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 Peptidase_S24 PF00717.23 EFX04616.1 - 2.9e-10 39.9 0.0 4.4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like IF-2B PF01008.17 EFX04617.1 - 2e-33 115.8 0.0 3e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EFX04617.1 - 0.043 13.7 0.1 2.3 8.1 0.1 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain OTU PF02338.19 EFX04618.1 - 5.1e-21 75.5 0.0 1.3e-20 74.2 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFX04618.1 - 0.00065 19.2 0.0 0.037 13.5 0.0 2.2 1 1 1 2 2 2 2 Peptidase C65 Otubain CDC45 PF02724.14 EFX04618.1 - 1.6 6.9 6.2 2 6.6 6.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Striatin PF08232.12 EFX04618.1 - 1.7 9.3 8.1 3.2 8.3 8.1 1.5 1 0 0 1 1 1 0 Striatin family DUF1925 PF09094.11 EFX04619.1 - 0.15 12.4 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) Syja_N PF02383.18 EFX04620.1 - 9.3e-75 251.9 0.0 1.6e-74 251.1 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Pro_CA PF00484.19 EFX04621.1 - 5.2e-12 46.3 0.5 4.7e-11 43.2 0.5 2.0 1 1 0 1 1 1 1 Carbonic anhydrase PET117 PF15786.5 EFX04622.1 - 6.2e-20 71.2 1.8 8.8e-20 70.8 1.8 1.2 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial CbtB PF09489.10 EFX04622.1 - 0.11 12.7 0.8 0.17 12.0 0.8 1.4 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Tyrosinase PF00264.20 EFX04623.1 - 8.4e-24 85.1 0.1 8.4e-24 85.1 0.1 2.3 3 0 0 3 3 3 1 Common central domain of tyrosinase Ank_2 PF12796.7 EFX04623.1 - 3.1e-12 46.9 0.0 1.6e-05 25.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX04623.1 - 1.3e-09 37.5 0.2 0.0014 18.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFX04623.1 - 4.2e-09 36.5 0.5 0.0023 18.2 0.1 2.8 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFX04623.1 - 8.4e-09 35.8 0.2 0.00048 20.6 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFX04623.1 - 3.3e-06 27.3 2.8 0.035 14.6 0.3 2.8 2 0 0 2 2 2 2 Ankyrin repeat bZIP_1 PF00170.21 EFX04623.1 - 0.12 12.5 8.6 0.28 11.3 8.6 1.6 1 0 0 1 1 1 0 bZIP transcription factor AAA PF00004.29 EFX04624.1 - 1.2e-15 58.1 0.0 2.3e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 EFX04624.1 - 1.4e-05 25.2 0.0 0.0091 16.2 0.0 2.9 2 0 0 2 2 2 2 AAA lid domain AAA_3 PF07726.11 EFX04624.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX04624.1 - 0.08 12.9 0.0 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EFX04624.1 - 0.11 12.3 0.3 0.54 10.0 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein RuvB_N PF05496.12 EFX04624.1 - 0.11 12.2 0.1 0.63 9.8 0.1 2.1 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFX04624.1 - 0.12 12.7 0.0 7.1 6.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain CutC PF03932.14 EFX04625.1 - 9.5e-25 87.3 0.6 1e-23 83.9 0.6 2.4 1 1 0 1 1 1 1 CutC family PHD_2 PF13831.6 EFX04625.1 - 0.097 12.2 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 PHD-finger Sugar_tr PF00083.24 EFX04626.1 - 7.7e-82 275.5 24.0 9.5e-82 275.2 24.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04626.1 - 1.4e-25 90.0 31.3 5.5e-25 88.0 31.1 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX04626.1 - 0.00023 19.7 3.8 0.00039 19.0 3.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) LMF1 PF06762.14 EFX04626.1 - 0.049 12.7 2.5 0.068 12.3 2.5 1.2 1 0 0 1 1 1 0 Lipase maturation factor RNA_pol_Rpb2_6 PF00562.28 EFX04627.1 - 2.5e-124 415.3 0.0 4e-124 414.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFX04627.1 - 2e-52 177.7 0.0 1.1e-51 175.3 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EFX04627.1 - 9.6e-48 162.3 0.0 1.9e-47 161.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EFX04627.1 - 5.5e-33 113.2 0.1 1.4e-32 111.9 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EFX04627.1 - 2e-25 88.7 0.1 6.1e-25 87.2 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EFX04627.1 - 1e-22 80.5 1.7 2.9e-22 79.0 1.7 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 EFX04627.1 - 3.1e-21 75.4 0.1 8.6e-21 74.0 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 SBF2 PF12335.8 EFX04627.1 - 0.0041 16.8 0.2 0.0088 15.7 0.2 1.5 1 0 0 1 1 1 1 Myotubularin protein RNA_pol_Rpb2_45 PF10385.9 EFX04627.1 - 0.074 13.3 0.4 2.3 8.5 0.1 2.8 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Pro_isomerase PF00160.21 EFX04628.1 - 7.1e-49 166.1 0.2 1e-48 165.6 0.2 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EFX04628.1 - 1.1e-08 34.5 5.5 0.00017 21.4 0.9 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX04628.1 - 2e-07 30.6 4.0 0.00038 20.1 0.4 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFX04628.1 - 0.00071 19.2 1.4 0.013 15.2 0.1 2.6 2 1 1 3 3 3 1 TPR repeat TPR_16 PF13432.6 EFX04628.1 - 0.001 19.7 8.9 0.29 11.8 4.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFX04628.1 - 0.0081 16.4 1.0 3.2 8.1 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX04628.1 - 0.02 15.6 4.8 0.088 13.7 1.9 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFX04628.1 - 0.031 14.9 1.5 1.4 9.7 0.3 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFX04628.1 - 0.032 14.4 2.5 0.24 11.6 0.7 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX04628.1 - 0.14 12.4 2.1 0.26 11.6 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat FMN_dh PF01070.18 EFX04629.1 - 5.1e-118 394.1 0.3 6.5e-118 393.7 0.3 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EFX04629.1 - 1.6e-22 79.4 0.1 7e-22 77.4 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EFX04629.1 - 1e-07 31.5 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EFX04629.1 - 0.0036 16.7 0.2 0.0075 15.7 0.2 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFX04629.1 - 0.0054 15.8 0.0 0.0089 15.1 0.0 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain BCDHK_Adom3 PF10436.9 EFX04630.1 - 1.4e-43 148.6 0.0 2.4e-43 147.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFX04630.1 - 1.8e-06 28.4 0.0 1.2e-05 25.8 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFX04630.1 - 0.032 14.1 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EFX04630.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain PALP PF00291.25 EFX04631.1 - 1.1e-60 205.6 6.3 4e-60 203.7 6.3 1.9 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme adh_short PF00106.25 EFX04631.1 - 1.8e-29 102.6 0.1 1.8e-29 102.6 0.1 2.6 3 0 0 3 3 3 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04631.1 - 3.2e-14 53.1 0.1 3.2e-14 53.1 0.1 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX04631.1 - 0.00032 20.7 10.8 0.0007 19.6 1.7 3.9 3 2 1 4 4 4 1 KR domain GATA PF00320.27 EFX04631.1 - 0.098 12.3 1.2 0.22 11.1 1.2 1.6 1 0 0 1 1 1 0 GATA zinc finger Polyoma_coat2 PF00761.20 EFX04631.1 - 1.3 8.6 4.0 0.4 10.3 0.9 1.7 2 0 0 2 2 2 0 Polyomavirus coat protein Aldolase_II PF00596.21 EFX04632.1 - 4.8e-45 153.8 0.0 6.1e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain VHS PF00790.19 EFX04633.1 - 2.1e-34 118.4 0.1 4.3e-34 117.4 0.1 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EFX04633.1 - 9.5e-17 60.4 0.0 1.9e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFX04633.1 - 2.2e-14 52.9 0.0 4.1e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFX04633.1 - 3.3e-14 52.5 0.1 6.6e-14 51.5 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EFX04633.1 - 7.8e-05 22.9 3.6 0.0005 20.3 0.6 3.0 3 0 0 3 3 3 1 GAT domain UIM PF02809.20 EFX04633.1 - 0.00052 19.8 3.0 0.0015 18.4 3.0 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif Presenilin PF01080.17 EFX04633.1 - 4.8 5.8 4.5 7.7 5.2 4.5 1.3 1 0 0 1 1 1 0 Presenilin zf-C2H2_4 PF13894.6 EFX04634.1 - 5.4e-08 33.0 1.9 0.0035 18.0 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFX04634.1 - 8e-07 29.2 3.0 0.004 17.5 0.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type Ribosomal_60s PF00428.19 EFX04634.1 - 0.00049 20.6 0.5 0.00049 20.6 0.5 3.0 2 1 0 2 2 2 1 60s Acidic ribosomal protein zf-C2H2_6 PF13912.6 EFX04634.1 - 0.061 13.4 1.3 0.93 9.6 0.4 2.3 1 1 1 2 2 2 0 C2H2-type zinc finger Pkinase PF00069.25 EFX04635.1 - 6.2e-69 232.3 0.0 1.4e-68 231.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04635.1 - 8e-33 113.8 0.0 5.6e-31 107.8 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX04635.1 - 4.7e-05 22.9 0.2 0.16 11.3 0.0 2.6 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EFX04635.1 - 0.0024 16.7 0.0 0.0056 15.5 0.0 1.8 2 1 0 2 2 2 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFX04635.1 - 0.26 10.2 0.5 0.41 9.5 0.5 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MMtag PF10159.9 EFX04636.1 - 9.5e-31 105.9 1.5 9.5e-31 105.9 1.5 3.6 2 1 0 2 2 2 1 Multiple myeloma tumor-associated Amino_oxidase PF01593.24 EFX04637.1 - 3.1e-57 194.9 0.5 5.8e-57 194.0 0.5 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFX04637.1 - 7.4e-15 54.9 0.2 1.6e-14 53.9 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX04637.1 - 1.7e-07 30.7 4.2 3e-07 29.9 4.2 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX04637.1 - 1.9e-06 27.3 0.0 3.1e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX04637.1 - 3.6e-06 26.8 3.8 6.7e-06 25.9 3.9 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFX04637.1 - 2.2e-05 24.0 2.6 3.1e-05 23.5 2.3 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFX04637.1 - 2.5e-05 23.7 1.2 4.2e-05 23.0 1.2 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFX04637.1 - 3.8e-05 22.6 0.2 6.4e-05 21.8 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EFX04637.1 - 7.9e-05 22.0 0.3 0.00025 20.4 0.4 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EFX04637.1 - 0.00015 22.3 1.3 0.00035 21.1 1.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX04637.1 - 0.00015 21.0 0.2 0.00023 20.4 0.2 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A K_oxygenase PF13434.6 EFX04637.1 - 0.00062 19.0 0.2 0.014 14.6 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 EFX04637.1 - 0.0015 17.8 0.1 0.0027 17.0 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EFX04637.1 - 0.0039 16.5 0.8 0.0061 15.9 0.8 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX04637.1 - 0.0091 15.1 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein 3HCDH_N PF02737.18 EFX04637.1 - 0.095 12.6 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 EFX04637.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_9 PF13454.6 EFX04637.1 - 0.32 11.0 4.1 8.7 6.3 0.1 2.6 2 1 0 2 2 2 0 FAD-NAD(P)-binding SR-25 PF10500.9 EFX04637.1 - 0.34 10.5 11.1 0.62 9.6 11.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spt5_N PF11942.8 EFX04637.1 - 0.38 11.8 4.2 11 7.0 1.2 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Tub_N PF16322.5 EFX04637.1 - 0.65 10.4 6.3 1.2 9.5 6.3 1.3 1 0 0 1 1 1 0 Tubby N-terminal BUD22 PF09073.10 EFX04637.1 - 2.5 7.3 5.5 3.7 6.8 5.5 1.2 1 0 0 1 1 1 0 BUD22 SRP19 PF01922.17 EFX04638.1 - 1.4e-31 109.3 0.0 2.1e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein Caskin-Pro-rich PF16907.5 EFX04638.1 - 0.099 13.2 5.7 1.2 9.7 0.2 2.6 2 0 0 2 2 2 0 Proline rich region of Caskin proteins Nucleoporin_FG PF13634.6 EFX04639.1 - 1.3e-11 45.1 67.7 1.2e-08 35.7 29.3 3.5 3 1 1 4 4 4 2 Nucleoporin FG repeat region DEC-1_N PF04625.13 EFX04641.1 - 0.2 10.6 6.4 0.29 10.1 6.4 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region NPL PF17800.1 EFX04642.1 - 0.059 13.9 2.4 20 5.8 0.0 3.7 3 1 1 4 4 4 0 Nucleoplasmin-like domain MFS_1 PF07690.16 EFX04643.1 - 2.7e-35 122.0 32.8 3.5e-35 121.6 32.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Tropomyosin PF00261.20 EFX04644.1 - 0.41 10.0 2.4 0.44 9.9 0.6 1.9 2 0 0 2 2 2 0 Tropomyosin zf-C2H2 PF00096.26 EFX04645.1 - 1.6e-05 25.1 18.2 0.0024 18.3 4.0 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type DIM1 PF02966.16 EFX04646.1 - 5.2e-65 217.2 0.2 5.9e-65 217.0 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.6 EFX04646.1 - 0.022 15.1 0.1 0.032 14.6 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like MaoC_dehydratas PF01575.19 EFX04647.1 - 2.2e-22 78.9 0.0 3.7e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EFX04647.1 - 6.5e-05 23.1 0.0 0.0025 17.9 0.0 2.5 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase Aconitase PF00330.20 EFX04648.1 - 6.1e-143 477.2 0.0 8e-143 476.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFX04648.1 - 1.1e-37 129.3 0.0 1.8e-37 128.6 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 EFX04648.1 - 0.18 10.4 0.0 0.44 9.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF521) KH_8 PF17903.1 EFX04649.1 - 1.1e-27 95.9 0.0 2.4e-27 94.8 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EFX04649.1 - 0.067 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 KH domain CTNNBL PF08216.11 EFX04650.1 - 1.2e-35 121.8 0.0 1.1e-34 118.7 0.0 2.3 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear MFS_1 PF07690.16 EFX04651.1 - 2.1e-20 73.0 17.5 2.1e-20 73.0 17.5 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily TPPK_C PF12555.8 EFX04651.1 - 0.074 13.1 0.8 2.8 8.0 0.1 3.0 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal PCRF PF03462.18 EFX04653.1 - 4.9e-47 160.3 1.4 4.9e-47 160.3 1.4 1.6 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EFX04653.1 - 1.2e-35 122.0 4.1 1.2e-35 122.0 4.1 2.0 2 0 0 2 2 2 1 RF-1 domain DUF1912 PF08930.10 EFX04653.1 - 0.0095 16.1 0.8 0.62 10.3 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1912) U1snRNP70_N PF12220.8 EFX04653.1 - 0.19 12.4 4.5 0.61 10.8 1.1 2.5 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal VSG_B PF13206.6 EFX04653.1 - 0.25 10.6 7.8 0.34 10.1 4.1 2.1 2 0 0 2 2 2 0 Trypanosomal VSG domain Ead_Ea22 PF13935.6 EFX04653.1 - 1.8 9.2 10.8 17 6.1 10.8 2.7 1 1 0 1 1 1 0 Ead/Ea22-like protein TAF4 PF05236.14 EFX04654.1 - 0.24 11.1 10.3 0.26 11.0 7.4 2.4 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family FOXP-CC PF16159.5 EFX04655.1 - 0.074 13.7 1.1 0.16 12.6 1.1 1.6 1 0 0 1 1 1 0 FOXP coiled-coil domain Acetyltransf_10 PF13673.7 EFX04656.1 - 3.9e-07 30.0 0.0 4.4e-07 29.9 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX04656.1 - 1.4e-06 28.6 0.0 1.7e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX04656.1 - 8.6e-05 22.8 0.0 0.0001 22.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFX04656.1 - 0.00019 21.4 0.0 0.00022 21.1 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFX04656.1 - 0.072 13.2 0.0 0.082 13.0 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Exo_endo_phos PF03372.23 EFX04657.1 - 2.4e-09 37.1 0.0 5.8e-09 35.8 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_trans_2_3 PF13632.6 EFX04657.1 - 2.8e-07 30.6 4.5 1.3e-05 25.2 0.0 3.6 2 1 1 3 3 3 2 Glycosyl transferase family group 2 HMG_box PF00505.19 EFX04658.1 - 2.6e-21 75.8 0.5 4.6e-21 75.0 0.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFX04658.1 - 0.003 18.1 0.1 0.0077 16.8 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EFX04658.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box FYVE PF01363.21 EFX04659.1 - 9.4e-15 54.5 6.2 1.7e-14 53.7 6.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 EFX04659.1 - 5.4 7.3 16.6 0.26 11.5 9.9 2.1 2 0 0 2 2 2 0 AN1-like Zinc finger Tudor_3 PF18115.1 EFX04660.1 - 9.3e-06 25.4 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain LBR_tudor PF09465.10 EFX04660.1 - 0.00064 19.5 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF4537 PF15057.6 EFX04660.1 - 0.0088 16.1 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) TauD PF02668.16 EFX04661.1 - 3.2e-32 112.4 0.2 4.2e-32 112.0 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF1918 PF08940.11 EFX04661.1 - 0.0019 17.8 0.1 0.0045 16.6 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1918) Ribosomal_L4 PF00573.22 EFX04662.1 - 2.5e-43 148.0 0.0 3.4e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Methyltransf_31 PF13847.6 EFX04663.1 - 6.3e-11 42.3 0.0 1.5e-10 41.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04663.1 - 2.4e-08 34.6 0.0 4.7e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX04663.1 - 9.9e-08 31.7 0.0 4.1e-07 29.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EFX04663.1 - 0.0001 22.2 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04663.1 - 0.00025 21.6 0.0 0.00048 20.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFX04663.1 - 0.00032 20.7 0.0 0.0005 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFX04663.1 - 0.001 18.9 0.0 0.0026 17.6 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) N6_Mtase PF02384.16 EFX04663.1 - 0.001 18.4 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase PrmC_N PF17827.1 EFX04663.1 - 0.0094 16.5 0.2 0.023 15.3 0.2 1.7 1 0 0 1 1 1 1 PrmC N-terminal domain Ubie_methyltran PF01209.18 EFX04663.1 - 0.012 15.0 0.0 0.017 14.4 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family UPF0020 PF01170.18 EFX04663.1 - 0.014 15.1 0.0 0.056 13.1 0.0 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 EFX04663.1 - 0.021 15.6 0.0 0.036 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EFX04663.1 - 0.035 13.5 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Mtc PF03820.17 EFX04663.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Tricarboxylate carrier Peptidase_C23 PF05379.11 EFX04663.1 - 0.2 11.8 0.0 0.39 10.9 0.0 1.4 1 0 0 1 1 1 0 Carlavirus endopeptidase COMPASS-Shg1 PF05205.12 EFX04664.1 - 4.2e-27 94.8 0.1 1.2e-26 93.4 0.1 1.8 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 Pribosyltran_N PF13793.6 EFX04665.1 - 8.6e-39 132.1 0.1 2.2e-37 127.5 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFX04665.1 - 4e-37 128.0 1.2 8e-31 107.5 0.3 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFX04665.1 - 1.2e-14 54.2 0.9 2.7e-14 53.0 0.9 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFX04665.1 - 0.013 14.9 0.4 0.021 14.3 0.4 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase DUF2007 PF09413.10 EFX04665.1 - 0.13 12.5 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein PCMT PF01135.19 EFX04666.1 - 3.3e-47 161.0 0.0 6.9e-47 159.9 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFX04666.1 - 1.4e-05 24.9 0.0 2.4e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFX04666.1 - 0.001 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04666.1 - 0.004 17.8 0.2 0.01 16.5 0.2 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04666.1 - 0.027 15.1 0.1 0.054 14.1 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFX04666.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.17 EFX04666.1 - 0.2 10.8 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin tRNA-synt_1g PF09334.11 EFX04667.1 - 8.3e-90 301.3 0.0 1.1e-57 195.6 0.5 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFX04667.1 - 3.7e-24 84.9 0.8 1.3e-11 43.5 0.1 3.4 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EFX04667.1 - 3.3e-07 30.0 0.0 0.0024 17.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain DUF2020 PF09449.10 EFX04667.1 - 0.066 13.1 0.6 0.2 11.5 0.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2020) SHS2_Rpb7-N PF03876.17 EFX04668.1 - 2.1e-14 53.6 0.0 3e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF2420 PF10336.9 EFX04669.1 - 1.5e-07 31.4 0.0 2.4e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Glyco_hydro_76 PF03663.14 EFX04670.1 - 2.2e-150 501.3 6.1 2.5e-150 501.1 6.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFX04670.1 - 0.033 13.3 6.4 2.7 7.0 0.1 3.1 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Exo70 PF03081.15 EFX04672.1 - 2.5e-91 306.6 0.0 4.7e-91 305.7 0.0 1.5 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Aminotran_3 PF00202.21 EFX04672.1 - 2.4e-84 283.4 0.0 4.1e-84 282.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III DUF2203 PF09969.9 EFX04672.1 - 0.2 12.4 0.2 0.88 10.3 0.2 2.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) TPR_14 PF13428.6 EFX04673.1 - 1.1e-20 72.6 30.9 0.00019 22.0 0.2 11.6 8 3 6 14 14 13 5 Tetratricopeptide repeat HAT PF02184.16 EFX04673.1 - 1.3e-17 63.5 61.4 2.7e-08 33.6 2.8 13.3 14 0 0 14 14 14 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 EFX04673.1 - 3.6e-16 59.4 0.1 2.5e-06 27.9 0.0 6.5 6 1 1 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 EFX04673.1 - 3.9e-15 56.6 16.5 0.00038 20.6 0.3 6.9 6 1 0 7 7 7 4 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EFX04673.1 - 2.8e-07 30.4 4.0 6.2 7.4 0.0 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFX04673.1 - 1.8e-06 27.7 0.8 0.52 10.7 0.0 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFX04673.1 - 0.00079 19.9 15.7 13 6.6 0.1 8.9 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_15 PF13429.6 EFX04673.1 - 0.0014 17.9 12.6 0.4 9.9 0.7 5.1 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX04673.1 - 0.0096 16.2 9.0 16 5.9 0.0 7.4 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFX04673.1 - 0.02 15.5 15.9 3.9 8.2 0.0 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EFX04673.1 - 0.031 14.3 18.2 0.26 11.4 1.3 6.5 5 2 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 TPR_9 PF13371.6 EFX04673.1 - 0.064 13.4 2.5 22 5.3 0.3 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat NRDE-2 PF08424.10 EFX04673.1 - 0.071 12.2 20.2 0.87 8.6 1.1 5.8 3 3 3 6 6 6 0 NRDE-2, necessary for RNA interference TPR_2 PF07719.17 EFX04673.1 - 0.26 11.5 18.4 0.76 10.0 0.0 8.0 10 0 0 10 10 10 0 Tetratricopeptide repeat SUIM_assoc PF16619.5 EFX04674.1 - 0.014 15.5 0.7 0.014 15.5 0.7 6.3 6 1 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 DUF4683 PF15735.5 EFX04674.1 - 0.73 9.4 6.2 0.067 12.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4683) MFS_1 PF07690.16 EFX04675.1 - 3.6e-17 62.3 38.7 1.8e-15 56.7 14.6 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EFX04675.1 - 5e-11 42.6 7.2 5e-11 42.6 7.2 2.1 2 0 0 2 2 2 1 Nodulin-like DUF2207 PF09972.9 EFX04675.1 - 5.9 5.5 6.7 1.1 8.0 0.7 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) NPP1 PF05630.11 EFX04676.1 - 1.4e-62 211.3 0.0 1.6e-62 211.1 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) GspL_C PF12693.7 EFX04677.1 - 0.044 13.6 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 GspL periplasmic domain LapA_dom PF06305.11 EFX04677.1 - 0.051 13.4 0.1 0.092 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain MCPVI PF02993.14 EFX04677.1 - 0.17 11.7 2.5 0.17 11.7 0.7 1.8 2 0 0 2 2 2 0 Minor capsid protein VI DUF2157 PF09925.9 EFX04677.1 - 0.2 11.4 0.3 0.35 10.7 0.1 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF4611 PF15387.6 EFX04678.1 - 0.072 13.3 2.1 0.91 9.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) stn_TNFRSF12A PF12191.8 EFX04678.1 - 0.088 13.0 1.9 0.95 9.7 0.2 2.7 2 1 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain SWIRM-assoc_2 PF16496.5 EFX04681.1 - 0.013 14.4 0.2 0.013 14.4 0.2 3.6 5 0 0 5 5 5 0 SWIRM-associated domain at the N-terminal DUF459 PF04311.13 EFX04681.1 - 0.1 11.5 0.3 0.21 10.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF459) AMMECR1 PF01871.17 EFX04682.1 - 1.2e-43 148.6 0.0 1.5e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Isochorismatase PF00857.20 EFX04683.1 - 5.7e-13 49.4 0.0 1.3e-12 48.2 0.0 1.6 1 1 0 1 1 1 1 Isochorismatase family V-ATPase_H_N PF03224.14 EFX04684.1 - 8.8e-65 219.0 0.0 1.1e-64 218.8 0.0 1.1 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EFX04684.1 - 2.4e-34 117.9 0.0 1.1e-33 115.8 0.0 2.2 2 0 0 2 2 2 1 V-ATPase subunit H Kelch_5 PF13854.6 EFX04685.1 - 9.3e-10 38.3 19.3 1.1e-09 38.1 0.6 5.8 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 EFX04685.1 - 6.3e-07 29.3 12.9 0.0046 16.9 0.3 5.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFX04685.1 - 8.5e-05 22.7 16.7 0.6 10.5 0.4 5.6 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFX04685.1 - 9.1e-05 22.0 8.1 0.018 14.6 0.1 5.7 6 0 0 6 6 6 1 Kelch motif VSP PF03302.13 EFX04685.1 - 0.00056 18.9 1.9 0.00086 18.3 1.9 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Kelch_2 PF07646.15 EFX04685.1 - 0.00056 19.8 11.4 5.6 7.1 0.0 6.7 7 0 0 7 7 7 2 Kelch motif SARAF PF06682.12 EFX04685.1 - 0.0011 18.7 1.2 0.0021 17.7 1.2 1.4 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Kelch_3 PF13415.6 EFX04685.1 - 0.0013 19.0 16.0 0.033 14.5 0.3 5.8 6 0 0 6 6 6 2 Galactose oxidase, central domain Herpes_gE PF02480.16 EFX04685.1 - 0.23 10.2 0.4 0.35 9.5 0.4 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E PhoLip_ATPase_C PF16212.5 EFX04686.1 - 3.9e-83 279.0 17.7 3.9e-83 279.0 17.7 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFX04686.1 - 2.9e-25 87.7 5.2 7.3e-25 86.4 5.2 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFX04686.1 - 6.7e-12 45.3 0.0 3.3e-11 43.1 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFX04686.1 - 2.7e-11 44.2 3.2 5.8e-07 30.0 0.7 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFX04686.1 - 1e-07 31.6 0.0 2.3e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFX04686.1 - 0.0012 18.6 0.5 0.0082 15.9 0.2 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Mt_ATP-synt_B PF05405.14 EFX04686.1 - 0.14 11.7 0.5 0.3 10.7 0.1 1.6 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF21 PF01595.20 EFX04686.1 - 2 8.1 6.8 0.97 9.1 0.4 2.6 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain AA_permease_2 PF13520.6 EFX04687.1 - 9.5e-64 215.8 52.3 1.1e-63 215.6 52.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX04687.1 - 1.3e-12 47.1 44.0 1.8e-12 46.6 44.0 1.1 1 0 0 1 1 1 1 Amino acid permease Acetyltransf_1 PF00583.25 EFX04688.1 - 4e-09 36.7 0.0 9.9e-09 35.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX04688.1 - 1.1e-07 32.2 0.0 4.1e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFX04688.1 - 1.9e-07 31.1 0.0 5.5e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX04688.1 - 0.00066 19.6 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFX04688.1 - 0.0017 18.4 0.0 0.35 11.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFX04688.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase LRR_6 PF13516.6 EFX04689.1 - 0.0025 17.7 14.7 7.7 6.9 0.0 7.0 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 EFX04689.1 - 0.53 10.8 8.8 24 5.5 0.0 5.2 4 1 2 6 6 6 0 Leucine Rich repeats (2 copies) Cnd1_N PF12922.7 EFX04690.1 - 1.1e-63 214.0 0.1 1.1e-63 214.0 0.1 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EFX04690.1 - 2.1e-47 161.1 0.0 1.3e-42 145.6 0.0 3.0 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFX04690.1 - 2.6e-08 33.4 3.2 0.31 11.4 0.0 6.1 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 EFX04690.1 - 5.4e-08 33.1 0.5 0.004 17.5 0.1 4.6 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 EFX04690.1 - 0.0013 19.2 5.8 0.22 12.1 0.3 5.0 5 0 0 5 5 5 1 HEAT-like repeat Cnd3 PF12719.7 EFX04690.1 - 0.014 14.6 0.3 0.014 14.6 0.3 2.9 4 0 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain G_glu_transpept PF01019.21 EFX04691.1 - 4.9e-142 474.3 0.0 5.6e-142 474.1 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase PhoLip_ATPase_C PF16212.5 EFX04692.1 - 1.4e-50 172.4 6.4 1.4e-50 172.4 6.4 2.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EFX04692.1 - 3.4e-14 53.6 1.9 6.4e-09 36.4 0.5 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.5 EFX04692.1 - 9.1e-09 34.9 0.1 2.5e-08 33.5 0.1 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFX04692.1 - 1.3e-06 28.4 0.0 2e-05 24.6 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFX04692.1 - 8e-06 25.5 3.1 0.00021 20.9 1.9 3.0 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFX04692.1 - 0.005 16.6 0.0 0.0093 15.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AA_permease_C PF13906.6 EFX04692.1 - 7.6 6.7 9.3 1.4 9.0 4.7 2.2 2 0 0 2 2 2 0 C-terminus of AA_permease Oxidored_FMN PF00724.20 EFX04693.1 - 7.8e-90 301.6 0.0 9e-90 301.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family LSM PF01423.22 EFX04694.1 - 0.0013 18.4 0.0 0.0024 17.5 0.0 1.5 1 1 0 1 1 1 1 LSM domain Abhydrolase_6 PF12697.7 EFX04695.1 - 4.8e-05 24.1 2.7 4.8e-05 24.1 2.7 3.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family AAA_16 PF13191.6 EFX04695.1 - 0.00014 22.3 0.0 0.00049 20.5 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain DUF676 PF05057.14 EFX04695.1 - 0.00038 20.0 0.0 0.00075 19.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EFX04695.1 - 0.01 15.1 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 EFX04695.1 - 0.051 13.3 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein RuvB_N PF05496.12 EFX04695.1 - 0.2 11.4 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TetR_C_6 PF13977.6 EFX04696.1 - 0.18 12.0 2.2 1.3 9.3 0.7 2.6 3 1 0 3 3 3 0 BetI-type transcriptional repressor, C-terminal Methyltransf_23 PF13489.6 EFX04697.1 - 2e-21 76.5 0.0 2.7e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04697.1 - 1.3e-12 48.2 0.0 4.6e-12 46.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04697.1 - 5.9e-11 42.9 0.0 1.1e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04697.1 - 1.1e-09 38.9 0.0 5.5e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04697.1 - 1.3e-08 34.8 0.0 4e-07 30.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04697.1 - 9.2e-07 28.4 0.0 2.2e-05 23.9 0.0 2.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFX04697.1 - 0.001 18.6 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase DUF938 PF06080.12 EFX04697.1 - 0.008 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PrmA PF06325.13 EFX04697.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFX04697.1 - 0.014 14.9 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EFX04697.1 - 0.038 14.1 0.1 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase CMAS PF02353.20 EFX04697.1 - 0.065 12.5 0.0 0.13 11.5 0.0 1.6 2 1 0 2 2 2 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EFX04697.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ribophorin_I PF04597.14 EFX04698.1 - 9e-155 516.2 0.1 1e-154 516.0 0.1 1.0 1 0 0 1 1 1 1 Ribophorin I Sugar_tr PF00083.24 EFX04699.1 - 2.7e-31 108.9 31.9 3.2e-20 72.4 13.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFX04699.1 - 2.2e-19 69.6 45.1 7.4e-11 41.6 29.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Methyltransf_25 PF13649.6 EFX04700.1 - 9.3e-16 58.3 0.0 1.4e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX04700.1 - 4.6e-12 46.1 0.0 1.2e-11 44.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04700.1 - 9e-11 42.4 0.0 1.3e-10 41.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04700.1 - 1.3e-10 41.8 0.0 2.7e-10 40.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04700.1 - 2.3e-07 30.4 0.0 3.3e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFX04700.1 - 5.5e-07 29.5 0.0 1.5e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFX04700.1 - 6.8e-05 22.3 0.0 7.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TPMT PF05724.11 EFX04700.1 - 0.00018 21.2 0.0 0.00031 20.5 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) MTS PF05175.14 EFX04700.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_20 PF12147.8 EFX04700.1 - 0.0019 17.4 0.0 0.0027 16.9 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EFX04700.1 - 0.0042 16.5 0.0 0.0052 16.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EFX04700.1 - 0.0063 16.0 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase PCMT PF01135.19 EFX04700.1 - 0.0073 16.1 0.0 0.009 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0146 PF03686.13 EFX04700.1 - 0.017 15.0 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_32 PF13679.6 EFX04700.1 - 0.018 15.0 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EFX04700.1 - 0.025 14.2 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) 3HCDH_N PF02737.18 EFX04700.1 - 0.07 13.0 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_9 PF08003.11 EFX04700.1 - 0.084 11.8 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) TrkA_N PF02254.18 EFX04700.1 - 0.19 12.0 0.0 0.51 10.6 0.0 1.6 2 0 0 2 2 2 0 TrkA-N domain Enoyl_reductase PF12241.8 EFX04704.1 - 0.0058 16.0 0.1 0.01 15.2 0.0 1.3 1 1 0 1 1 1 1 Trans-2-enoyl-CoA reductase catalytic region DAGAT PF03982.13 EFX04705.1 - 9.4e-86 287.4 0.0 1.2e-85 287.0 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase OAM_alpha PF16552.5 EFX04705.1 - 0.2 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 D-ornithine 4,5-aminomutase alpha-subunit ThiJ_like PF17124.5 EFX04707.1 - 0.13 11.9 0.1 0.13 11.9 0.1 2.0 1 1 0 2 2 2 0 ThiJ/PfpI family-like MDFI PF15316.6 EFX04707.1 - 1.6 8.7 3.8 8.6 6.4 0.0 2.4 2 0 0 2 2 2 0 MyoD family inhibitor Hamartin PF04388.12 EFX04707.1 - 6.7 5.2 13.5 7.7 5.1 13.5 1.1 1 0 0 1 1 1 0 Hamartin protein DNA_mis_repair PF01119.19 EFX04708.1 - 2.9e-19 68.9 0.0 5.7e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 EFX04708.1 - 6.9e-19 68.1 0.1 4.3e-18 65.5 0.1 2.3 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EFX04708.1 - 7.1e-10 38.8 0.0 1.5e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFX04708.1 - 1.2e-05 25.7 0.1 6.5e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DnaJ PF00226.31 EFX04710.1 - 5.3e-12 45.7 1.4 5.3e-12 45.7 1.4 1.9 2 0 0 2 2 2 1 DnaJ domain Vpu PF00558.19 EFX04710.1 - 2.3 8.0 4.1 1.7 8.5 0.1 2.1 1 1 1 2 2 2 0 Vpu protein Cupin_8 PF13621.6 EFX04713.1 - 1.3e-23 84.1 0.0 1.8e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EFX04713.1 - 0.00012 21.6 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EFX04713.1 - 0.0022 18.4 0.0 0.051 14.0 0.0 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 EFX04713.1 - 0.03 14.0 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain FMO-like PF00743.19 EFX04714.1 - 8.6e-11 41.0 0.0 1e-09 37.4 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFX04714.1 - 1.4e-09 38.1 0.1 2.4e-08 34.1 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX04714.1 - 8.1e-09 35.1 0.0 3.7e-07 29.7 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX04714.1 - 1.1e-07 31.5 0.3 8.5e-07 28.5 0.1 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX04714.1 - 6.8e-07 29.2 2.2 0.0061 16.2 0.6 3.7 2 1 0 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.17 EFX04714.1 - 4.9e-06 25.9 0.0 4.9e-06 25.9 0.0 1.9 3 0 0 3 3 3 1 Thi4 family K_oxygenase PF13434.6 EFX04714.1 - 8.1e-05 21.9 0.3 0.024 13.8 0.0 3.4 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EFX04714.1 - 0.0014 19.1 0.0 2.2 8.9 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX04714.1 - 0.0015 17.7 0.2 0.014 14.5 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Shikimate_DH PF01488.20 EFX04714.1 - 0.0015 18.6 0.0 0.04 14.0 0.0 2.7 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EFX04714.1 - 0.0037 16.4 0.0 0.0051 15.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EFX04714.1 - 0.0039 16.5 0.1 0.0092 15.3 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EFX04714.1 - 0.024 13.7 0.1 0.62 9.1 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Amino_oxidase PF01593.24 EFX04714.1 - 0.035 13.4 0.1 0.25 10.6 0.0 2.4 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EFX04714.1 - 0.04 13.3 0.1 0.04 13.3 0.1 1.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX04714.1 - 0.042 13.8 0.4 20 5.1 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding LSM PF01423.22 EFX04715.1 - 3.9e-22 77.7 0.1 4.3e-22 77.6 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFX04715.1 - 0.05 13.7 0.0 0.06 13.5 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain AMP-binding PF00501.28 EFX04716.1 - 1.8e-74 250.9 0.0 2.3e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX04716.1 - 1.3e-10 42.1 0.0 2.7e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 EFX04717.1 - 1.1e-17 64.1 30.5 1.1e-17 64.1 30.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CRT10 PF08728.10 EFX04718.1 - 1.7e-07 29.8 2.0 2.5e-05 22.7 0.0 3.1 3 0 0 3 3 3 2 CRT10 Zip PF02535.22 EFX04718.1 - 0.031 13.5 10.0 0.028 13.6 4.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4820 PF16091.5 EFX04718.1 - 0.26 10.6 9.0 0.011 15.1 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) TipE PF16972.5 EFX04718.1 - 0.55 9.4 11.9 0.85 8.7 11.9 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE RgpF PF05045.12 EFX04719.1 - 0.0059 15.4 0.1 0.021 13.6 0.0 1.8 2 0 0 2 2 2 1 Rhamnan synthesis protein F Dsh_C PF12316.8 EFX04720.1 - 0.093 13.1 2.7 0.15 12.4 2.7 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal G-alpha PF00503.20 EFX04721.1 - 1.9e-115 385.8 1.1 2.2e-115 385.6 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFX04721.1 - 7.4e-15 54.8 1.3 4e-10 39.4 0.2 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFX04721.1 - 0.00013 21.4 0.1 0.099 12.0 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFX04721.1 - 0.0018 18.5 0.5 0.96 9.7 0.0 2.7 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EFX04721.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RibD_C PF01872.17 EFX04722.1 - 0.068 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 RibD C-terminal domain Ank_2 PF12796.7 EFX04723.1 - 1.1e-53 179.7 0.1 2.2e-16 60.2 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 EFX04723.1 - 7.6e-38 127.3 0.5 0.00043 20.6 0.0 8.5 9 0 0 9 9 7 7 Ankyrin repeat Ank_5 PF13857.6 EFX04723.1 - 1.3e-37 127.3 1.3 6.3e-08 32.7 0.0 6.3 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFX04723.1 - 7.9e-37 125.2 0.4 3.2e-10 40.3 0.0 6.4 4 1 2 7 7 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX04723.1 - 6.5e-24 81.4 0.0 0.039 14.5 0.0 8.6 8 0 0 8 8 7 5 Ankyrin repeat NACHT PF05729.12 EFX04723.1 - 3.9e-09 36.6 0.1 9.3e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 NACHT domain DUF676 PF05057.14 EFX04723.1 - 1.5e-05 24.6 0.0 4.2e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) AAA_22 PF13401.6 EFX04723.1 - 0.0028 17.9 0.0 0.021 15.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX04723.1 - 0.0033 17.8 0.1 0.013 15.9 0.1 2.1 1 0 0 1 1 1 1 AAA ATPase domain Abhydrolase_6 PF12697.7 EFX04723.1 - 0.0033 18.0 0.9 0.0088 16.7 0.2 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family AAA_29 PF13555.6 EFX04723.1 - 0.014 15.1 0.0 0.069 12.9 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain PGAP1 PF07819.13 EFX04723.1 - 0.026 14.2 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein AAA_30 PF13604.6 EFX04723.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain VCH_CASS14 PF18315.1 EFX04723.1 - 0.08 13.0 0.0 1.2 9.2 0.0 2.7 2 1 1 3 3 3 0 Integron cassette protein VCH_CASS1 chain Viral_helicase1 PF01443.18 EFX04723.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Abhydrolase_1 PF00561.20 EFX04723.1 - 0.14 11.8 0.1 0.33 10.6 0.1 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Rpr2 PF04032.16 EFX04723.1 - 0.14 12.4 0.1 0.44 10.9 0.1 1.8 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain RNA_pol_Rpb1_5 PF04998.17 EFX04724.1 - 2.5e-77 259.9 0.1 3.8e-77 259.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFX04724.1 - 7.1e-72 241.0 0.0 1.5e-71 240.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EFX04724.1 - 2e-53 181.7 0.0 4.3e-48 164.2 0.0 2.6 2 1 1 3 3 3 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 EFX04724.1 - 2.3e-34 118.6 0.0 5.1e-34 117.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFX04724.1 - 7.2e-27 93.5 0.1 2.3e-26 91.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Peptidase_S8 PF00082.22 EFX04725.1 - 3.2e-42 144.8 2.7 6.2e-42 143.9 2.7 1.5 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EFX04725.1 - 2.7e-09 37.7 0.1 9.9e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Fn3-like domain Fungal_trans PF04082.18 EFX04726.1 - 2.2e-66 223.7 0.1 3.1e-66 223.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFX04726.1 - 0.0023 18.3 4.0 0.0023 18.3 4.0 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type TauD PF02668.16 EFX04728.1 - 9.1e-14 51.9 0.0 4.3e-10 39.8 0.0 2.1 1 1 1 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EFX04728.1 - 0.022 13.9 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 CsiD adh_short_C2 PF13561.6 EFX04729.1 - 3.6e-58 196.9 1.1 4.6e-58 196.6 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX04729.1 - 4.3e-39 134.0 0.2 5.2e-39 133.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX04729.1 - 9.5e-10 38.7 0.4 1.6e-09 37.9 0.4 1.3 1 0 0 1 1 1 1 KR domain ThiF PF00899.21 EFX04729.1 - 0.0036 16.7 0.9 0.023 14.0 0.5 2.2 1 1 1 2 2 2 1 ThiF family Epimerase PF01370.21 EFX04729.1 - 0.011 15.2 0.1 0.19 11.2 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Nbl1_Borealin_N PF10444.9 EFX04731.1 - 6.3e-21 73.8 2.0 9.7e-21 73.2 2.0 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal Aldedh PF00171.22 EFX04732.1 - 6.7e-07 28.2 0.0 0.012 14.2 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Glyco_hydro_92 PF07971.12 EFX04733.1 - 6.2e-141 470.5 0.0 8.8e-141 470.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 HECT PF00632.25 EFX04733.1 - 9.8e-72 242.0 0.0 1.9e-71 241.1 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Glyco_hydro_92N PF17678.1 EFX04733.1 - 5.1e-67 226.3 1.7 9.1e-67 225.4 1.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Tim17 PF02466.19 EFX04734.1 - 9.9e-25 87.1 2.9 1.6e-24 86.4 2.9 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family NBD_C PF17042.5 EFX04734.1 - 0.0032 18.0 0.4 0.0045 17.5 0.4 1.2 1 0 0 1 1 1 1 Nucleotide-binding C-terminal domain ORC6 PF05460.13 EFX04734.1 - 0.71 9.1 2.3 0.9 8.7 2.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF202 PF02656.15 EFX04735.1 - 5e-16 58.9 3.5 5e-16 58.9 3.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Bax1-I PF01027.20 EFX04735.1 - 0.01 15.7 4.6 0.014 15.3 4.6 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF983 PF06170.12 EFX04735.1 - 0.031 14.7 3.3 2.1 8.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF983) 7tm_6 PF02949.20 EFX04735.1 - 0.077 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 7tm Odorant receptor DUF4231 PF14015.6 EFX04735.1 - 1.3 9.5 4.5 0.51 10.8 1.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) ASXH PF13919.6 EFX04736.1 - 4.8e-36 123.8 0.8 8.5e-36 123.0 0.8 1.4 1 0 0 1 1 1 1 Asx homology domain PI-PLC-X PF00388.19 EFX04737.1 - 2.3e-06 27.3 0.0 3.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain adh_short_C2 PF13561.6 EFX04738.1 - 1.1e-55 188.7 0.2 3e-55 187.3 0.2 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX04738.1 - 4.3e-33 114.4 0.1 1.4e-32 112.8 0.1 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX04738.1 - 3.6e-06 27.0 0.3 0.00063 19.7 0.0 2.2 1 1 1 2 2 2 2 KR domain 2-Hacid_dh_C PF02826.19 EFX04738.1 - 0.0021 17.5 0.1 0.0052 16.2 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PALP PF00291.25 EFX04738.1 - 0.015 14.7 0.1 0.024 14.1 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Sacchrp_dh_NADP PF03435.18 EFX04738.1 - 0.1 12.9 0.2 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Sde2_N_Ubi PF13019.6 EFX04739.1 - 0.19 11.6 1.0 0.37 10.6 1.0 1.4 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain MGC-24 PF05283.11 EFX04739.1 - 1.4 9.4 14.7 0.18 12.3 10.3 1.8 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PLA2_B PF01735.18 EFX04741.1 - 6.1e-182 605.4 12.8 3.4e-153 510.6 1.5 2.1 1 1 1 2 2 2 2 Lysophospholipase catalytic domain La PF05383.17 EFX04742.1 - 3.9e-18 65.3 0.0 6.9e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 La domain NUDIX PF00293.28 EFX04743.1 - 1.1e-16 61.0 1.6 1.3e-16 60.8 1.6 1.1 1 0 0 1 1 1 1 NUDIX domain Methyltransf_25 PF13649.6 EFX04744.1 - 0.0023 18.6 0.1 0.021 15.5 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04744.1 - 0.035 14.7 0.0 0.23 12.1 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04744.1 - 0.061 14.1 0.0 0.18 12.6 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain GFA PF04828.14 EFX04745.1 - 3.6e-12 46.5 0.3 6.3e-12 45.7 0.3 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DUF2434 PF10361.9 EFX04746.1 - 1.8e-136 453.9 10.5 2.3e-136 453.6 10.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Ribosomal_L19e PF01280.20 EFX04747.1 - 3e-61 205.7 6.2 3e-61 205.7 6.2 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e Fungal_trans PF04082.18 EFX04748.1 - 8.3e-21 74.2 0.1 1.2e-20 73.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04748.1 - 9.8e-10 38.4 10.1 2.4e-09 37.2 10.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HECT_2 PF09814.9 EFX04749.1 - 1.2e-75 254.7 0.0 1.4e-73 248.0 0.0 2.3 1 1 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding SNF2_N PF00176.23 EFX04749.1 - 7.6e-39 133.4 0.0 2.2e-34 118.7 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX04749.1 - 1.7e-07 31.6 0.1 3.6e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX04749.1 - 0.00067 19.7 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DUF655 PF04919.12 EFX04749.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF655) Peptidase_M48_N PF16491.5 EFX04750.1 - 1e-61 208.0 7.7 1e-61 208.0 7.7 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EFX04750.1 - 8.7e-45 152.9 0.1 1.5e-44 152.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M48 Ribosomal_L34 PF00468.17 EFX04750.1 - 1.7e-13 50.3 12.6 3.9e-13 49.1 12.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L34 DUF4538 PF15061.6 EFX04750.1 - 0.23 11.2 0.5 0.5 10.2 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Hus1 PF04005.12 EFX04752.1 - 4.9e-64 216.3 0.0 7.1e-64 215.7 0.0 1.2 1 0 0 1 1 1 1 Hus1-like protein zf-RING_2 PF13639.6 EFX04752.1 - 2e-07 31.2 0.7 4.4e-07 30.1 0.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFX04752.1 - 1.7e-05 24.6 0.3 0.0001 22.1 0.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFX04752.1 - 2.2e-05 24.6 0.3 4.9e-05 23.5 0.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFX04752.1 - 8.4e-05 22.3 2.4 9.1e-05 22.2 0.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX04752.1 - 0.00027 20.7 0.4 0.00027 20.7 0.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFX04752.1 - 0.016 15.2 0.1 0.032 14.3 0.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EFX04752.1 - 0.059 13.3 0.2 0.059 13.3 0.2 1.7 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EFX04752.1 - 0.061 13.2 2.2 0.16 11.9 2.2 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFX04752.1 - 0.18 11.9 7.8 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 RING-type zinc-finger YdjO PF14169.6 EFX04752.1 - 0.27 11.0 2.6 0.23 11.2 0.3 2.0 2 0 0 2 2 2 0 Cold-inducible protein YdjO zf-C3HC4_4 PF15227.6 EFX04752.1 - 0.47 10.6 3.0 0.47 10.7 0.7 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING GTP_EFTU PF00009.27 EFX04753.1 - 4.2e-51 173.3 0.0 6.2e-51 172.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EFX04753.1 - 6.7e-42 142.0 4.0 1.2e-41 141.1 4.0 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EFX04753.1 - 3.9e-15 55.7 0.0 7.2e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EFX04753.1 - 1.4e-05 25.1 0.0 5.7e-05 23.1 0.0 2.1 2 1 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFX04753.1 - 7.3e-05 23.1 0.1 0.00015 22.1 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 EFX04753.1 - 0.00059 19.5 0.0 0.0016 18.0 0.0 1.6 2 0 0 2 2 2 1 Ras family RF3_C PF16658.5 EFX04753.1 - 0.0033 17.3 0.0 0.0092 15.8 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EFX04753.1 - 0.0083 15.6 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ORF_2_N PF18492.1 EFX04753.1 - 0.16 12.1 2.1 10 6.4 0.0 3.2 2 1 0 3 3 3 0 Open reading frame 2 N-terminal domain Acetyltransf_1 PF00583.25 EFX04754.1 - 0.0013 18.9 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family P-mevalo_kinase PF04275.14 EFX04755.1 - 2.8e-21 75.6 0.0 4.8e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Phosphomevalonate kinase Pribosyltran PF00156.27 EFX04755.1 - 3.2e-17 62.5 0.0 6.5e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain FAD_binding_4 PF01565.23 EFX04755.1 - 3.7e-13 49.4 6.5 4.5e-13 49.1 4.8 2.0 2 0 0 2 2 2 1 FAD binding domain UPRTase PF14681.6 EFX04755.1 - 1.3e-05 24.8 0.0 2.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EFX04755.1 - 0.0036 16.8 0.0 0.078 12.5 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase BBE PF08031.12 EFX04755.1 - 0.034 14.3 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like Sigma54_activ_2 PF14532.6 EFX04755.1 - 0.15 12.2 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Amidase PF01425.21 EFX04756.1 - 1.1e-85 288.3 0.0 1.4e-85 287.9 0.0 1.0 1 0 0 1 1 1 1 Amidase DUF1134 PF06577.12 EFX04756.1 - 0.074 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1134) Cmc1 PF08583.10 EFX04757.1 - 2e-18 66.1 1.7 2e-18 66.1 1.7 1.7 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EFX04757.1 - 0.029 14.4 0.9 0.051 13.6 0.9 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EFX04757.1 - 0.1 12.8 5.0 3.6 7.8 0.3 2.2 2 0 0 2 2 2 0 CHCH domain DUF3128 PF11326.8 EFX04757.1 - 2.4 8.6 6.9 1.7e+02 2.6 6.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) GEN1_C PF18380.1 EFX04758.1 - 0.099 13.5 2.0 0.16 12.9 2.0 1.3 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain RNA_pol_Rpb4 PF03874.16 EFX04759.1 - 1.9e-23 83.1 0.5 2.4e-23 82.8 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 ATG13 PF10033.9 EFX04760.1 - 1.5e-73 247.5 0.0 4e-73 246.0 0.0 1.7 2 0 0 2 2 2 1 Autophagy-related protein 13 TFIIA PF03153.13 EFX04760.1 - 0.00089 19.4 22.7 0.047 13.7 14.1 2.6 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF4604 PF15377.6 EFX04760.1 - 0.26 11.7 14.6 0.074 13.5 4.6 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4604) PAT1 PF09770.9 EFX04760.1 - 0.59 8.3 13.6 0.92 7.7 13.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Beta-lactamase PF00144.24 EFX04762.1 - 3.5e-23 82.4 0.0 4.4e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase adh_short_C2 PF13561.6 EFX04763.1 - 3.5e-41 141.3 3.4 1.1e-40 139.7 3.4 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX04763.1 - 5.7e-41 140.1 3.7 1.3e-40 139.0 3.5 1.7 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EFX04763.1 - 5.7e-08 32.9 1.4 5.7e-08 32.9 1.4 2.0 1 1 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 EFX04763.1 - 0.00025 21.0 1.4 0.00041 20.3 1.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFX04763.1 - 0.008 15.7 3.7 0.052 13.0 3.7 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 EFX04763.1 - 0.011 16.3 0.3 0.038 14.5 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt_2 PF02719.15 EFX04763.1 - 0.014 14.6 0.1 0.023 13.8 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ADH_zinc_N PF00107.26 EFX04763.1 - 0.019 15.0 1.1 0.036 14.0 1.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase NAD_Gly3P_dh_N PF01210.23 EFX04763.1 - 0.024 14.6 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 EFX04763.1 - 0.027 14.6 0.1 0.059 13.5 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3Beta_HSD PF01073.19 EFX04763.1 - 0.036 13.1 0.0 0.057 12.4 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EFX04763.1 - 0.067 12.5 0.2 0.25 10.7 0.0 1.9 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_tran_WecB PF03808.13 EFX04763.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family TrkA_N PF02254.18 EFX04763.1 - 0.085 13.1 0.3 0.15 12.3 0.3 1.4 1 0 0 1 1 1 0 TrkA-N domain DUF1776 PF08643.10 EFX04763.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Sec7 PF01369.20 EFX04765.1 - 1.4e-70 236.8 0.2 1.4e-70 236.8 0.2 2.2 3 0 0 3 3 3 1 Sec7 domain DUF1981 PF09324.10 EFX04765.1 - 2.1e-32 110.8 7.0 3.6e-31 106.9 0.0 5.0 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Sec7_N PF12783.7 EFX04765.1 - 2.3e-27 95.8 6.6 1.2e-20 74.1 0.1 3.7 2 1 1 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EFX04765.1 - 4.9e-21 75.2 0.0 1.1e-17 64.2 0.0 3.5 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 CLASP_N PF12348.8 EFX04765.1 - 0.036 13.6 0.4 10 5.6 0.2 2.7 2 0 0 2 2 2 0 CLASP N terminal TRAPP PF04051.16 EFX04766.1 - 1.6e-39 134.9 0.0 1.9e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Macro PF01661.21 EFX04767.1 - 1.5e-41 141.1 0.1 2.4e-41 140.5 0.1 1.3 1 0 0 1 1 1 1 Macro domain ADH_zinc_N PF00107.26 EFX04769.1 - 1.6e-16 60.5 0.1 2.3e-16 60.0 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX04769.1 - 4.3e-09 37.5 0.0 9.3e-09 36.4 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX04769.1 - 9.1e-05 22.3 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EFX04769.1 - 0.0064 16.0 0.1 0.013 15.0 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 EFX04770.1 - 1.5e-11 44.5 0.1 2.1e-11 44.0 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EFX04770.1 - 0.00032 20.8 0.2 0.00046 20.3 0.2 1.3 1 0 0 1 1 1 1 Acyl-carrier DUF1776 PF08643.10 EFX04771.1 - 2.2e-93 312.9 0.0 4.4e-93 311.9 0.0 1.5 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EFX04771.1 - 0.032 13.7 0.0 0.81 9.1 0.0 2.9 2 1 0 2 2 2 0 short chain dehydrogenase BATS PF06968.13 EFX04774.1 - 2.2e-23 82.2 0.1 8.2e-23 80.4 0.1 2.0 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EFX04774.1 - 1e-11 45.5 0.1 2.8e-11 44.1 0.1 1.7 2 0 0 2 2 2 1 Radical SAM superfamily CoA_transf_3 PF02515.17 EFX04776.1 - 5.3e-34 117.9 0.0 3.5e-33 115.2 0.0 2.1 2 0 0 2 2 2 1 CoA-transferase family III Dioxygenase_N PF04444.14 EFX04776.1 - 1.2e-27 95.6 0.1 2.4e-27 94.6 0.1 1.6 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Dioxygenase_C PF00775.21 EFX04776.1 - 1.3e-21 76.9 0.2 2.8e-21 75.8 0.0 1.6 2 0 0 2 2 2 1 Dioxygenase CarboxypepD_reg PF13620.6 EFX04776.1 - 2.4e-05 24.5 0.0 5.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain NMO PF03060.15 EFX04777.1 - 1.7e-53 182.2 0.1 1.2e-52 179.4 0.1 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFX04777.1 - 5.5e-12 45.4 0.0 3.6e-09 36.1 0.0 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFX04777.1 - 0.0046 16.0 0.4 0.0074 15.3 0.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Nitro_FeMo-Co PF02579.17 EFX04777.1 - 0.092 13.1 0.1 0.22 11.9 0.1 1.6 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor Nuc_sug_transp PF04142.15 EFX04778.1 - 2.6e-91 306.1 7.9 5e-91 305.1 7.9 1.4 1 1 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EFX04778.1 - 7.6e-08 31.9 12.5 9.2e-07 28.4 12.4 2.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EFX04778.1 - 0.00017 21.8 26.8 0.0014 18.9 6.1 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EFX04778.1 - 0.0043 16.5 15.0 0.025 13.9 1.8 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family DCA16 PF15349.6 EFX04778.1 - 0.074 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 TMEM234 PF10639.9 EFX04778.1 - 0.097 12.7 12.0 0.26 11.3 0.8 2.6 3 0 0 3 3 3 0 Putative transmembrane family 234 DUF1071 PF06378.11 EFX04778.1 - 0.12 12.0 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Abhydrolase_3 PF07859.13 EFX04779.1 - 1.9e-43 148.8 0.0 2.5e-43 148.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFX04779.1 - 1.9e-06 27.0 0.1 5e-06 25.7 0.1 1.6 1 1 0 1 1 1 1 Carboxylesterase family DUF4128 PF13554.6 EFX04779.1 - 0.0023 18.0 0.0 0.0041 17.2 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage related domain of unknown function Mid2 PF04478.12 EFX04780.1 - 0.0058 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor SARAF PF06682.12 EFX04780.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4311 PF14188.6 EFX04780.1 - 0.082 12.7 0.7 0.27 11.0 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4311) DUF5305 PF17231.2 EFX04780.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) GPP34 PF05719.11 EFX04781.1 - 3.6e-69 232.9 1.8 4.5e-69 232.6 1.8 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) DUF4776 PF16003.5 EFX04782.1 - 0.015 14.3 0.0 0.016 14.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) TRP PF06011.12 EFX04783.1 - 7.6e-165 548.8 32.1 9.7e-165 548.4 32.1 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFX04783.1 - 2.9e-44 150.8 1.2 4.9e-44 150.1 1.2 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.15 EFX04783.1 - 0.0022 18.4 0.1 0.0041 17.5 0.1 1.4 1 0 0 1 1 1 1 ML domain Shisa PF13908.6 EFX04783.1 - 3.8 7.7 7.1 0.49 10.6 0.8 2.7 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator DUF4579 PF15158.6 EFX04783.1 - 8.2 6.1 9.4 0.42 10.4 0.4 2.8 1 1 1 3 3 3 0 Domain of unknown function (DUF4579) TauD PF02668.16 EFX04784.1 - 1.5e-48 166.0 0.1 1.6e-48 165.8 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PigN PF04987.14 EFX04785.1 - 7.3e-165 549.2 31.3 1.1e-164 548.6 31.3 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EFX04785.1 - 1.3e-09 38.2 4.2 2.6e-07 30.6 4.2 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFX04785.1 - 3.8e-09 36.4 0.1 6.3e-09 35.7 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EFX04785.1 - 7.3e-05 22.3 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily FeoB_associated PF12669.7 EFX04785.1 - 3.5 8.1 5.4 13 6.3 0.2 3.2 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Apolipoprotein PF01442.18 EFX04786.1 - 0.0022 17.9 11.4 0.019 14.8 11.6 1.9 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain SpoIIIAH PF12685.7 EFX04786.1 - 0.039 13.8 7.0 0.053 13.3 7.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF883 PF05957.13 EFX04786.1 - 0.051 14.2 16.5 1.1 9.9 13.1 2.7 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) V-ATPase_G_2 PF16999.5 EFX04786.1 - 3.1 8.2 18.3 2.9 8.4 17.2 1.4 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Ribosomal_L15e PF00827.17 EFX04788.1 - 2.6e-90 301.3 10.2 3.2e-90 301.0 10.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 He_PIG PF05345.12 EFX04789.1 - 2.1e-12 47.0 11.3 0.00016 21.7 0.4 4.9 4 0 0 4 4 4 4 Putative Ig domain TMEM154 PF15102.6 EFX04789.1 - 0.058 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family Aldo_ket_red PF00248.21 EFX04790.1 - 2.9e-54 184.3 0.0 3.2e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PLDc PF00614.22 EFX04791.1 - 1.5e-16 59.8 0.3 2.6e-07 30.5 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFX04791.1 - 1.8e-12 47.3 0.0 1.1e-07 31.8 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 EFX04791.1 - 0.00036 20.5 0.0 0.0052 16.8 0.0 2.7 2 1 0 2 2 2 1 PX domain Ino80_Iec3 PF14612.6 EFX04792.1 - 1.5e-63 215.6 0.0 2.5e-63 214.9 0.0 1.4 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling FYDLN_acid PF09538.10 EFX04792.1 - 1.5 9.5 8.1 6.3 7.5 8.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) EBP PF05241.12 EFX04793.1 - 2.4e-47 160.7 6.0 3.4e-47 160.2 6.0 1.2 1 0 0 1 1 1 1 Emopamil binding protein zf-H2C2_2 PF13465.6 EFX04794.1 - 0.00021 21.6 0.2 0.00021 21.6 0.2 3.2 3 0 0 3 3 3 1 Zinc-finger double domain FOXP-CC PF16159.5 EFX04794.1 - 0.00049 20.7 10.7 0.07 13.8 1.4 3.9 2 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2 PF00096.26 EFX04794.1 - 0.00077 19.8 2.5 0.15 12.6 0.0 3.3 2 1 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX04794.1 - 0.58 11.1 5.2 16 6.6 0.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Aa_trans PF01490.18 EFX04795.1 - 2e-25 89.4 30.6 2.4e-25 89.1 30.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CD52 PF15116.6 EFX04795.1 - 0.03 14.4 1.3 0.098 12.7 1.3 1.9 1 0 0 1 1 1 0 CAMPATH-1 antigen S_4TM PF18159.1 EFX04795.1 - 2.2 7.5 3.9 0.74 9.1 0.2 2.1 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain IFRD PF05004.13 EFX04796.1 - 1.8e-78 263.8 3.7 2.6e-78 263.2 3.7 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) MBF1 PF08523.10 EFX04797.1 - 3.2e-25 88.4 5.4 3.3e-25 88.3 2.7 2.0 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EFX04797.1 - 1.2e-10 41.2 0.0 2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EFX04797.1 - 0.0002 21.7 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 EFX04797.1 - 0.017 15.0 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain YdaS_antitoxin PF15943.5 EFX04797.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT His_Phos_2 PF00328.22 EFX04798.1 - 1.7e-50 172.5 0.0 2.4e-50 172.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) HET PF06985.11 EFX04798.1 - 7.7e-20 71.7 0.0 1.7e-19 70.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Transformer PF06495.11 EFX04799.1 - 0.73 9.9 21.4 1.1 9.3 19.1 2.4 2 0 0 2 2 2 0 Fruit fly transformer protein TCO89 PF10452.9 EFX04800.1 - 4.9e-08 32.4 0.0 4.9e-08 32.4 0.0 3.3 2 1 0 3 3 2 1 TORC1 subunit TCO89 SNF2_N PF00176.23 EFX04800.1 - 6.7e-06 25.0 0.0 6.7e-06 25.0 0.0 2.9 3 0 0 3 3 2 1 SNF2 family N-terminal domain MCU PF04678.13 EFX04800.1 - 0.26 11.4 7.6 1 9.4 7.2 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter MecA PF05389.12 EFX04800.1 - 0.44 10.1 4.1 2.2 7.9 4.9 1.7 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Mcm10 PF09332.11 EFX04800.1 - 1.4 8.3 23.1 2.9 7.2 23.1 1.5 1 0 0 1 1 1 0 Mcm10 replication factor Spt20 PF12090.8 EFX04800.1 - 1.4 8.5 36.5 0.046 13.3 27.2 2.7 2 0 0 2 2 2 0 Spt20 family NST1 PF13945.6 EFX04800.1 - 4.8 7.2 16.7 13 5.9 16.7 1.8 1 0 0 1 1 1 0 Salt tolerance down-regulator Dicty_REP PF05086.12 EFX04800.1 - 6.3 4.6 7.3 9.1 4.1 7.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CPSF100_C PF13299.6 EFX04800.1 - 7.3 6.7 9.6 36 4.5 9.6 2.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Rxt3 PF08642.10 EFX04800.1 - 7.7 7.3 7.4 31 5.4 7.4 2.0 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 DUF775 PF05603.12 EFX04800.1 - 7.9 6.0 12.2 18 4.8 12.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF3464 PF11947.8 EFX04800.1 - 9.4 6.0 9.0 31 4.3 9.0 1.9 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF962 PF06127.11 EFX04801.1 - 2.8e-24 85.0 1.6 4.1e-24 84.5 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) 2-oxoacid_dh PF00198.23 EFX04802.1 - 1.7e-72 243.7 0.1 2.3e-72 243.2 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFX04802.1 - 2e-16 59.5 0.2 4.1e-16 58.6 0.2 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EFX04802.1 - 2.3e-09 37.4 0.4 7.7e-09 35.8 0.4 2.0 1 0 0 1 1 1 1 e3 binding domain DUF3614 PF12267.8 EFX04802.1 - 0.0056 17.2 0.3 0.013 16.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3614) DUF3597 PF12200.8 EFX04802.1 - 0.15 12.6 3.7 0.9 10.1 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) DUF5488 PF17590.2 EFX04802.1 - 0.64 9.8 1.9 23 4.8 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5488) PRiA4_ORF3 PF07929.11 EFX04803.1 - 3.4e-17 62.7 0.2 4.3e-17 62.4 0.2 1.1 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein CHB_HEX_C PF03174.13 EFX04803.1 - 0.0024 17.8 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain p450 PF00067.22 EFX04804.1 - 6.6e-65 219.6 0.0 1.2e-64 218.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 KilA-N PF04383.13 EFX04805.1 - 0.00027 20.8 0.0 0.0054 16.6 0.0 2.3 1 1 0 1 1 1 1 KilA-N domain Pirin_C_2 PF17954.1 EFX04806.1 - 0.17 12.0 0.0 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 Quercetinase C-terminal cupin domain Ala_racemase_N PF01168.20 EFX04807.1 - 1.9e-20 73.5 0.1 2.8e-20 72.9 0.1 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain TRP_2 PF08344.11 EFX04808.1 - 0.14 12.4 3.3 0.27 11.5 3.3 1.4 1 0 0 1 1 1 0 Transient receptor ion channel II F-box-like PF12937.7 EFX04809.1 - 0.021 14.7 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 F-box-like Uds1 PF15456.6 EFX04810.1 - 2e-40 137.9 24.7 3.1e-40 137.4 4.0 7.5 6 1 1 7 7 7 2 Up-regulated During Septation DUF3450 PF11932.8 EFX04810.1 - 0.0046 16.3 7.2 0.0046 16.3 7.2 8.3 6 1 2 9 9 9 1 Protein of unknown function (DUF3450) HR1 PF02185.16 EFX04810.1 - 0.011 15.8 0.5 0.011 15.8 0.5 9.8 6 2 2 9 9 9 0 Hr1 repeat DASH_Dam1 PF08653.10 EFX04810.1 - 0.4 10.5 0.0 0.4 10.5 0.0 4.7 6 0 0 6 6 6 0 DASH complex subunit Dam1 CTP_transf_like PF01467.26 EFX04811.1 - 5.8e-24 84.9 0.0 4.7e-20 72.2 0.0 3.5 4 1 0 4 4 4 2 Cytidylyltransferase-like DNA_pol_alpha_N PF12254.8 EFX04812.1 - 0.12 12.5 0.0 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal Zip PF02535.22 EFX04813.1 - 3.1e-51 174.6 0.2 3.8e-51 174.3 0.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter ATP_sub_h PF10775.9 EFX04814.1 - 2.3e-25 88.4 0.8 3.3e-25 87.8 0.8 1.3 1 0 0 1 1 1 1 ATP synthase complex subunit h CBS PF00571.28 EFX04815.1 - 3.2e-24 85.1 7.3 1e-09 38.7 0.2 4.4 4 0 0 4 4 4 4 CBS domain UPRTase PF14681.6 EFX04816.1 - 2.7e-33 115.2 0.0 4.6e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EFX04816.1 - 5.1e-32 111.2 0.0 8.9e-18 64.7 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 EFX04816.1 - 2.2e-06 27.6 0.0 6.8e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 EFX04816.1 - 0.0015 19.1 0.0 0.0035 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFX04816.1 - 0.0041 17.6 0.1 0.022 15.3 0.0 2.2 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.6 EFX04816.1 - 0.0066 16.6 0.0 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 EFX04816.1 - 0.021 14.5 0.1 0.046 13.4 0.1 1.4 1 1 0 1 1 1 0 Cytidylate kinase DUF87 PF01935.17 EFX04816.1 - 0.023 14.8 0.7 0.072 13.2 0.7 1.8 1 1 0 1 1 1 0 Helicase HerA, central domain Zeta_toxin PF06414.12 EFX04816.1 - 0.03 13.6 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EFX04816.1 - 0.031 14.0 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX04816.1 - 0.033 14.6 0.1 0.13 12.7 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EFX04816.1 - 0.063 12.5 0.0 0.24 10.6 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.6 EFX04816.1 - 0.063 13.0 0.1 0.85 9.4 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA PF00004.29 EFX04816.1 - 0.12 12.8 0.0 0.37 11.2 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Serglycin PF04360.12 EFX04817.1 - 3.7 7.5 14.1 1.9 8.4 0.6 3.8 3 0 0 3 3 3 0 Serglycin Sulfate_transp PF00916.20 EFX04818.1 - 4.6e-110 368.0 17.8 5.8e-110 367.6 17.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EFX04818.1 - 2.6e-09 36.7 0.0 5.5e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EFX04818.1 - 0.00014 22.2 3.3 0.00014 22.2 3.3 3.1 2 2 0 2 2 2 2 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 EFX04818.1 - 0.076 13.4 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 STAS domain zf_UBZ PF18439.1 EFX04818.1 - 0.11 12.1 0.7 0.21 11.2 0.7 1.4 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger SNN_transmemb PF09049.10 EFX04818.1 - 3.3 7.7 7.2 1.1 9.2 0.8 3.1 2 0 0 2 2 2 0 Stannin transmembrane Glyco_hydro_61 PF03443.14 EFX04819.1 - 1.5e-55 188.3 0.0 2.2e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 TPT PF03151.16 EFX04821.1 - 9.3e-18 64.6 14.8 3e-17 62.9 14.8 1.7 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFX04821.1 - 4.1e-06 27.0 28.9 0.0018 18.5 16.9 2.6 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFX04821.1 - 0.56 9.4 18.6 1.3 8.2 18.6 1.6 1 1 0 1 1 1 0 UAA transporter family Histidinol_dh PF00815.20 EFX04822.1 - 2.4e-159 530.7 4.7 3.3e-159 530.3 4.7 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EFX04822.1 - 7.2e-22 77.0 0.0 1.3e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EFX04822.1 - 2.7e-12 47.0 0.1 7.7e-12 45.5 0.1 1.9 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase Mito_carr PF00153.27 EFX04823.1 - 5.4e-69 228.2 0.3 1.4e-22 79.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFX04823.1 - 0.17 11.0 0.2 3.9 6.5 0.1 2.7 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Snf7 PF03357.21 EFX04824.1 - 3e-15 56.3 4.6 3e-15 56.3 4.6 2.0 2 0 0 2 2 2 1 Snf7 CHCH PF06747.13 EFX04825.1 - 3.2e-06 27.1 6.5 4.9e-06 26.5 6.5 1.3 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 EFX04825.1 - 0.0014 19.0 1.6 0.0031 17.9 1.6 1.6 1 0 0 1 1 1 1 GCK domain FAD_binding_6 PF00970.24 EFX04826.1 - 1.3e-08 35.1 0.0 2.6e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFX04826.1 - 3.5e-05 24.4 0.0 9.4e-05 23.0 0.0 1.8 1 1 1 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFX04826.1 - 0.00022 21.4 0.0 0.00051 20.2 0.0 1.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain WD40 PF00400.32 EFX04827.1 - 7e-33 112.1 9.6 1.9e-06 28.5 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX04827.1 - 2.4e-11 43.8 0.1 0.013 15.8 0.0 3.6 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2749 PF10907.8 EFX04827.1 - 0.22 11.7 2.1 3.2 8.0 0.5 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) COX5B PF01215.19 EFX04828.1 - 2e-54 182.8 0.0 2.5e-54 182.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb DUF4604 PF15377.6 EFX04829.1 - 2.4e-35 122.5 13.3 3.6e-35 121.9 13.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Sec62 PF03839.16 EFX04829.1 - 9.7 5.6 6.9 12 5.3 6.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 HRI1 PF16815.5 EFX04830.1 - 1.9e-44 152.1 0.0 2.2e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Protein HRI1 NAD_binding_8 PF13450.6 EFX04831.1 - 3.9e-08 33.4 0.1 1.1e-07 32.0 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EFX04831.1 - 8.2e-08 32.0 0.2 6e-07 29.1 0.2 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EFX04831.1 - 5.1e-07 29.4 0.1 8.8e-07 28.6 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX04831.1 - 1.5e-05 24.3 0.6 2.5e-05 23.6 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFX04831.1 - 0.00013 20.8 0.0 0.0002 20.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 EFX04831.1 - 0.00026 20.3 0.0 0.00041 19.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX04831.1 - 0.00047 20.7 0.3 0.0014 19.1 0.3 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX04831.1 - 0.00053 19.3 0.0 0.0016 17.7 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EFX04831.1 - 0.00074 18.8 0.3 0.0017 17.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFX04831.1 - 0.0012 18.2 0.6 0.002 17.5 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX04831.1 - 0.0016 18.1 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EFX04831.1 - 0.0022 17.1 0.1 0.0037 16.4 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX04831.1 - 0.0099 15.0 0.2 0.019 14.0 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EFX04831.1 - 0.025 13.9 0.9 0.039 13.3 0.2 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 EFX04831.1 - 0.027 14.1 0.1 0.053 13.1 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 EFX04831.1 - 0.032 14.7 0.1 0.1 13.1 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Aldo_ket_red PF00248.21 EFX04832.1 - 1.8e-38 132.4 0.0 3.8e-36 124.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family ketoacyl-synt PF00109.26 EFX04833.1 - 3e-58 197.4 0.1 1.3e-57 195.3 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFX04833.1 - 3.7e-27 95.7 1.0 1.1e-26 94.2 1.0 1.7 1 0 0 1 1 1 1 Acyl transferase domain Lactonase PF10282.9 EFX04833.1 - 2.8e-26 92.6 0.6 5.1e-26 91.7 0.6 1.4 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller NAD_binding_4 PF07993.12 EFX04833.1 - 2.9e-25 88.9 0.0 5.6e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EFX04833.1 - 6e-24 84.3 0.1 1.5e-22 79.8 0.1 2.6 1 1 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EFX04833.1 - 2.9e-10 40.4 0.2 2e-09 37.7 0.1 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site SAT PF16073.5 EFX04833.1 - 1e-08 35.2 2.5 0.0022 17.8 0.0 2.8 3 0 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis PS-DH PF14765.6 EFX04833.1 - 4.3e-05 22.9 0.1 8.8e-05 21.9 0.1 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Epimerase PF01370.21 EFX04833.1 - 6.7e-05 22.5 0.0 0.00026 20.6 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EFX04833.1 - 0.00047 20.3 0.1 0.0023 18.1 0.1 2.2 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus KAsynt_C_assoc PF16197.5 EFX04833.1 - 0.0008 19.9 0.0 0.004 17.6 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EFX04833.1 - 0.0039 16.6 0.0 0.015 14.6 0.0 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain SGL PF08450.12 EFX04833.1 - 0.0051 16.4 0.1 0.019 14.6 0.0 2.0 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Polysacc_synt_2 PF02719.15 EFX04833.1 - 0.12 11.5 0.0 0.31 10.1 0.0 1.7 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GFA PF04828.14 EFX04835.1 - 3.1e-10 40.3 2.6 4.8e-10 39.6 2.6 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Collagen PF01391.18 EFX04836.1 - 0.014 15.2 9.3 0.03 14.1 9.3 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Serglycin PF04360.12 EFX04836.1 - 0.023 14.6 2.8 0.049 13.6 2.8 1.4 1 0 0 1 1 1 0 Serglycin zf-C2H2_jaz PF12171.8 EFX04837.1 - 3.1e-06 27.3 3.0 4.6e-06 26.8 3.0 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX04837.1 - 0.0013 19.1 0.5 0.002 18.4 0.5 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Response_reg PF00072.24 EFX04838.1 - 2.5e-19 69.5 0.0 2.9e-13 50.0 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain Ycf66_N PF07444.11 EFX04839.1 - 4.5 7.5 8.2 0.84 9.8 0.2 3.2 3 1 0 3 3 3 0 Ycf66 protein N-terminus PIEZO PF15917.5 EFX04840.1 - 0.37 10.2 3.2 0.6 9.5 3.2 1.3 1 0 0 1 1 1 0 Piezo TT_ORF2 PF02957.15 EFX04840.1 - 8.6 7.3 14.8 7.9 7.4 4.3 2.5 1 1 2 3 3 3 0 TT viral ORF2 DUF4111 PF13427.6 EFX04841.1 - 0.027 14.6 0.0 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4111) Ish1 PF10281.9 EFX04841.1 - 0.029 14.7 0.0 0.056 13.8 0.0 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein CobD_Cbib PF03186.13 EFX04841.1 - 0.09 12.0 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 CobD/Cbib protein DOCK_N PF16172.5 EFX04843.1 - 0.17 10.8 1.3 0.2 10.5 1.3 1.1 1 0 0 1 1 1 0 DOCK N-terminus MAJIN PF15077.6 EFX04843.1 - 7.9 6.2 7.8 11 5.8 7.8 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein NT-C2 PF10358.9 EFX04844.1 - 3.4e-26 91.7 0.0 2.8e-22 79.0 0.0 2.2 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins Abhydrolase_1 PF00561.20 EFX04845.1 - 7.8e-21 74.9 0.1 6.5e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EFX04845.1 - 5.3e-17 61.8 0.0 1.3e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Fungal_trans PF04082.18 EFX04846.1 - 1.8e-07 30.5 0.8 3.6e-07 29.5 0.0 1.9 2 1 1 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04846.1 - 1.6e-06 28.1 9.7 3.6e-06 27.0 9.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactonase PF10282.9 EFX04847.1 - 0.0014 18.0 0.3 0.085 12.1 0.0 2.8 1 1 2 3 3 3 2 Lactonase, 7-bladed beta-propeller DNA_pol_B PF00136.21 EFX04849.1 - 1.6e-89 300.7 0.0 3.3e-89 299.7 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFX04849.1 - 1.6e-09 37.4 0.0 2.1e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain Tugs PF17840.1 EFX04849.1 - 0.012 15.7 0.0 0.033 14.4 0.0 1.7 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Bac_luciferase PF00296.20 EFX04850.1 - 1.5e-73 248.0 0.2 1.8e-73 247.7 0.2 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase AP_endonuc_2 PF01261.24 EFX04850.1 - 0.086 12.3 0.1 2.3 7.6 0.0 2.6 3 0 0 3 3 3 0 Xylose isomerase-like TIM barrel HNH_repeat PF18780.1 EFX04850.1 - 2.5 8.0 4.0 7.3 6.5 0.3 2.5 2 0 0 2 2 2 0 Homing endonuclease repeat FAD_binding_3 PF01494.19 EFX04851.1 - 7e-71 239.3 0.4 1.3e-70 238.4 0.4 1.4 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EFX04851.1 - 9.1e-27 94.1 0.0 1.8e-26 93.1 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain NAD_binding_8 PF13450.6 EFX04851.1 - 5.3e-06 26.6 1.3 6.5e-05 23.1 0.0 3.2 3 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX04851.1 - 7.6e-05 22.4 0.8 0.0019 17.9 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFX04851.1 - 9.4e-05 21.3 0.0 0.00014 20.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EFX04851.1 - 9.6e-05 21.7 0.0 0.00051 19.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX04851.1 - 0.00052 19.2 0.2 0.0012 18.0 0.2 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EFX04851.1 - 0.00061 20.3 0.1 0.0013 19.2 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EFX04851.1 - 0.001 18.5 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain XdhC_C PF13478.6 EFX04851.1 - 0.0021 18.6 0.0 0.0057 17.1 0.0 1.8 1 0 0 1 1 1 1 XdhC Rossmann domain FAD_binding_2 PF00890.24 EFX04851.1 - 0.003 16.7 0.4 0.0067 15.6 0.4 1.6 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFX04851.1 - 0.0033 16.7 0.0 0.0065 15.7 0.0 1.5 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 EFX04851.1 - 0.013 14.6 0.1 0.019 14.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EFX04851.1 - 0.021 13.7 0.0 0.068 12.0 0.0 1.8 2 0 0 2 2 2 0 Tryptophan halogenase FAD_oxidored PF12831.7 EFX04851.1 - 0.021 14.2 0.2 0.044 13.1 0.2 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFX04851.1 - 0.025 13.8 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EFX04851.1 - 0.13 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EFX04851.1 - 0.17 11.7 0.1 0.35 10.7 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sugar_tr PF00083.24 EFX04852.1 - 1e-77 261.9 17.4 1.3e-77 261.6 17.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04852.1 - 3.3e-15 55.9 22.2 3.3e-15 55.9 22.2 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily TPR_9 PF13371.6 EFX04852.1 - 0.11 12.6 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Polysacc_deac_1 PF01522.21 EFX04853.1 - 5.1e-18 65.2 0.0 1.2e-17 64.0 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 EFX04853.1 - 2.8e-06 27.2 0.1 1.6e-05 24.7 0.0 2.2 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 EFX04853.1 - 0.073 11.4 0.0 0.1 10.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) Surp PF01805.20 EFX04854.1 - 1e-34 118.3 0.7 3.9e-16 58.8 0.0 2.3 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 EFX04854.1 - 2.8e-20 73.1 3.0 3.8e-20 72.7 3.0 1.1 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein LON_substr_bdg PF02190.16 EFX04854.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain Helo_like_N PF17111.5 EFX04855.1 - 3.1e-06 26.7 0.1 7.5e-06 25.5 0.1 1.7 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Amidohydro_1 PF01979.20 EFX04857.1 - 6.2e-47 160.6 0.2 7.8e-47 160.2 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX04857.1 - 3.2e-10 40.1 0.3 1e-09 38.4 0.1 1.8 1 1 0 1 1 1 1 Amidohydrolase family DUF4537 PF15057.6 EFX04857.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Ank_2 PF12796.7 EFX04858.1 - 5.1e-39 132.7 8.8 2.8e-15 56.7 0.2 4.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) MFS_1 PF07690.16 EFX04858.1 - 8.9e-29 100.5 28.4 1.4e-28 99.8 28.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily NACHT_N PF17100.5 EFX04858.1 - 2.3e-26 93.0 0.8 5.3e-26 91.8 0.8 1.6 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase Ank_4 PF13637.6 EFX04858.1 - 1.2e-23 83.1 0.1 2e-06 28.2 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EFX04858.1 - 1.2e-17 63.4 6.8 0.019 15.4 0.1 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFX04858.1 - 1.7e-12 47.3 0.2 0.044 14.1 0.0 5.7 1 1 5 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX04858.1 - 2.9e-12 45.6 0.5 1.3 9.8 0.0 6.7 7 0 0 7 7 6 2 Ankyrin repeat Sugar_tr PF00083.24 EFX04858.1 - 1.5e-10 40.6 8.1 1.5e-10 40.6 8.1 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFX04858.1 - 0.0011 17.5 2.4 0.0019 16.7 2.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) NACHT PF05729.12 EFX04858.1 - 0.0095 15.9 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFX04858.1 - 0.12 12.8 0.1 0.46 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Fungal_trans PF04082.18 EFX04860.1 - 1.3e-22 80.1 1.1 2.1e-22 79.4 1.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04860.1 - 2.7e-08 33.8 12.2 5.3e-08 32.9 12.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ring_hydroxyl_A PF00848.19 EFX04861.1 - 6.5e-21 75.3 4.0 2.2e-17 63.7 4.0 2.3 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EFX04861.1 - 3.9e-11 42.7 0.0 7.4e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain HET PF06985.11 EFX04862.1 - 2.2e-25 89.7 0.1 8e-25 87.9 0.1 2.0 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF1088 PF06469.11 EFX04862.1 - 0.0082 15.8 0.2 0.013 15.1 0.2 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) Zn_clus PF00172.18 EFX04863.1 - 2.1e-05 24.6 10.0 2.1e-05 24.6 10.0 2.9 3 1 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain UBA_4 PF14555.6 EFX04864.1 - 9.2e-10 38.2 0.1 2.2e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFX04864.1 - 0.0003 20.9 0.0 0.00075 19.7 0.0 1.7 1 0 0 1 1 1 1 UBX domain Serglycin PF04360.12 EFX04864.1 - 0.17 11.8 0.5 0.36 10.8 0.5 1.5 1 0 0 1 1 1 0 Serglycin DUF1682 PF07946.14 EFX04864.1 - 3.7 6.7 10.0 5.6 6.1 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Fungal_trans_2 PF11951.8 EFX04865.1 - 0.0062 15.4 0.1 0.022 13.6 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Bac_rhamnosid6H PF17389.2 EFX04866.1 - 7.4e-13 48.5 1.1 3.6e-12 46.2 1.7 1.9 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Trehalase PF01204.18 EFX04866.1 - 4.3e-08 32.4 0.0 6.7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Trehalase FMN_dh PF01070.18 EFX04867.1 - 6.8e-86 288.4 0.3 6.1e-47 160.3 0.2 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.25 EFX04867.1 - 0.0015 17.6 0.1 0.02 13.9 0.0 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EFX04867.1 - 0.0061 16.0 0.0 0.0087 15.5 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EFX04867.1 - 0.056 12.8 0.0 4.2 6.6 0.0 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EFX04867.1 - 0.057 12.9 0.4 0.91 8.9 0.0 2.5 1 1 1 2 2 2 0 Histidine biosynthesis protein DHO_dh PF01180.21 EFX04867.1 - 0.078 12.2 0.1 0.53 9.4 0.0 2.1 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EFX04867.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase Amidohydro_1 PF01979.20 EFX04869.1 - 1e-54 186.2 0.0 1.2e-54 186.0 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX04869.1 - 1.6e-11 44.3 0.3 5.9e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 EFX04869.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Adenosine/AMP deaminase MFS_1 PF07690.16 EFX04872.1 - 1.8e-47 162.0 82.4 5.1e-40 137.5 54.6 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EFX04873.1 - 1.6e-15 56.9 20.0 1.6e-15 56.9 20.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFX04873.1 - 6.2e-15 55.3 1.3 6.2e-15 55.3 1.3 2.2 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 OATP PF03137.20 EFX04873.1 - 0.0052 15.1 4.4 0.037 12.3 0.5 2.3 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Anophelin PF10731.9 EFX04874.1 - 0.27 11.1 1.7 2 8.4 1.1 2.7 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito SET PF00856.28 EFX04875.1 - 3.2e-16 60.2 0.2 3.2e-16 60.2 0.2 3.6 2 2 0 3 3 3 1 SET domain AWS PF17907.1 EFX04875.1 - 3.7e-08 33.3 7.4 8.6e-08 32.1 7.4 1.6 1 0 0 1 1 1 1 AWS domain Mito_carr PF00153.27 EFX04876.1 - 4.2e-69 228.6 0.3 5.5e-22 77.5 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_42 PF02449.15 EFX04876.1 - 0.22 10.8 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase DUF883 PF05957.13 EFX04876.1 - 1.1 9.9 6.2 8 7.1 1.4 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) HEAT_2 PF13646.6 EFX04877.1 - 1.1e-10 41.7 11.2 1.9e-06 28.1 1.4 3.4 2 2 2 4 4 4 3 HEAT repeats HEAT PF02985.22 EFX04877.1 - 0.0003 20.8 1.3 6.5 7.3 0.1 4.0 3 0 0 3 3 3 3 HEAT repeat HEAT_EZ PF13513.6 EFX04877.1 - 0.012 16.1 3.7 18 5.9 0.1 4.3 4 0 0 4 4 4 0 HEAT-like repeat Cnd1 PF12717.7 EFX04877.1 - 0.13 12.3 0.0 0.39 10.8 0.0 1.8 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Tir_receptor_N PF07490.11 EFX04878.1 - 0.037 13.9 0.0 0.05 13.4 0.0 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus Phage_Capsid_P3 PF09018.11 EFX04878.1 - 0.093 11.5 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 P3 major capsid protein MFS_1 PF07690.16 EFX04879.1 - 4e-28 98.4 26.3 4e-28 98.4 26.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EFX04880.1 - 6.4e-21 74.7 50.5 5.5e-20 71.6 45.1 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX04880.1 - 1.3e-14 53.6 27.3 2.3e-14 52.7 27.3 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PIRT PF15099.6 EFX04880.1 - 1.3 8.6 6.2 29 4.2 0.1 3.4 3 0 0 3 3 3 0 Phosphoinositide-interacting protein family Glyco_trans_1_4 PF13692.6 EFX04881.1 - 1.3e-11 45.1 0.0 2.8e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EFX04881.1 - 1.4e-11 44.2 0.0 3.5e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 DnaG_DnaB_bind PF08278.11 EFX04881.1 - 0.15 12.6 0.1 0.65 10.6 0.1 2.1 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding Glyco_trans_1_2 PF13524.6 EFX04881.1 - 0.16 12.4 0.0 0.5 10.8 0.0 1.9 1 1 0 1 1 1 0 Glycosyl transferases group 1 SNARE PF05739.19 EFX04882.1 - 2.9e-12 46.4 0.0 6.3e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 EFX04882.1 - 1e-05 24.6 4.1 2.5e-05 23.4 4.1 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 EFX04882.1 - 0.0032 17.2 0.1 0.0032 17.2 0.1 2.6 3 0 0 3 3 3 2 Syntaxin DUF5559 PF17714.1 EFX04882.1 - 0.012 15.6 0.1 0.022 14.6 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5559) TRPM_tetra PF16519.5 EFX04882.1 - 0.092 12.9 0.5 0.29 11.3 0.5 1.9 1 0 0 1 1 1 0 Tetramerisation domain of TRPM SlyX PF04102.12 EFX04882.1 - 0.19 12.4 0.1 0.19 12.4 0.1 3.5 4 1 1 5 5 5 0 SlyX Prominin PF05478.11 EFX04882.1 - 0.22 9.4 1.6 3.2 5.6 0.0 2.1 2 0 0 2 2 2 0 Prominin KxDL PF10241.9 EFX04882.1 - 0.29 11.4 6.1 12 6.3 0.4 3.8 4 0 0 4 4 4 0 Uncharacterized conserved protein His_Phos_1 PF00300.22 EFX04883.1 - 2.1e-34 118.9 1.2 1.8e-14 53.9 0.0 3.5 2 1 2 4 4 4 3 Histidine phosphatase superfamily (branch 1) Transp_cyt_pur PF02133.15 EFX04884.1 - 2.2e-88 296.9 35.6 2.6e-88 296.7 35.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sugar_tr PF00083.24 EFX04885.1 - 1.6e-102 343.7 25.7 1.9e-102 343.5 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04885.1 - 4.3e-27 94.9 30.6 4.3e-27 94.9 30.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EFX04885.1 - 0.0088 14.9 0.0 0.0088 14.9 0.0 3.3 2 2 1 3 3 3 1 MFS_1 like family Epimerase PF01370.21 EFX04886.1 - 6.8e-36 123.9 0.0 5.7e-35 120.9 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX04886.1 - 5.1e-31 108.3 0.0 7.1e-30 104.5 0.0 2.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFX04886.1 - 9.3e-09 34.8 0.1 4.8e-08 32.5 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EFX04886.1 - 3.4e-07 29.6 0.1 5.4e-06 25.6 0.1 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFX04886.1 - 1.8e-06 27.3 0.2 0.00047 19.4 0.4 3.5 3 1 0 3 3 3 1 Polysaccharide biosynthesis protein KR PF08659.10 EFX04886.1 - 0.00036 20.5 0.0 0.00093 19.2 0.0 1.6 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EFX04886.1 - 0.0022 17.5 0.0 0.004 16.6 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase VCBS PF13517.6 EFX04887.1 - 0.02 15.5 0.0 0.024 15.2 0.0 1.1 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella ADIP PF11559.8 EFX04888.1 - 0.013 15.6 0.1 0.02 15.0 0.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FYVE PF01363.21 EFX04888.1 - 6.3 7.0 11.0 7 6.9 8.5 2.2 2 0 0 2 2 2 0 FYVE zinc finger AA_permease_2 PF13520.6 EFX04889.1 - 7.4e-46 156.8 54.2 8.8e-46 156.6 54.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX04889.1 - 9.5e-18 64.0 47.5 1.3e-17 63.6 47.5 1.1 1 0 0 1 1 1 1 Amino acid permease Sterol_MT_C PF08498.10 EFX04890.1 - 1.1e-26 92.9 0.3 1.9e-26 92.1 0.3 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EFX04890.1 - 2.7e-21 76.0 0.0 4.7e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04890.1 - 3.3e-19 69.4 0.0 6.4e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04890.1 - 1.5e-18 67.0 0.0 2.2e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFX04890.1 - 6.4e-12 45.3 0.1 9.4e-12 44.8 0.1 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFX04890.1 - 1e-10 41.7 0.0 1.6e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04890.1 - 3.1e-10 39.8 0.0 5.1e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFX04890.1 - 1.6e-09 38.4 0.0 3.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFX04890.1 - 7.4e-06 25.9 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EFX04890.1 - 0.00014 21.5 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EFX04890.1 - 0.00028 20.4 0.1 0.0041 16.6 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFX04890.1 - 0.0023 17.5 0.0 0.0053 16.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EFX04890.1 - 0.0042 16.4 0.0 0.0065 15.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain MetW PF07021.12 EFX04890.1 - 0.0064 16.1 0.0 0.03 13.9 0.0 1.9 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_29 PF03141.16 EFX04890.1 - 0.0079 14.8 0.0 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase FAM177 PF14774.6 EFX04890.1 - 0.026 14.9 1.7 1 9.7 0.3 2.4 2 0 0 2 2 2 0 FAM177 family RrnaAD PF00398.20 EFX04890.1 - 0.033 13.2 0.0 0.052 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 EFX04890.1 - 0.084 12.3 0.5 0.28 10.6 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EFX04890.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_24 PF13578.6 EFX04890.1 - 0.13 13.3 0.1 0.41 11.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFX04890.1 - 0.14 12.1 1.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain ISN1 PF06437.11 EFX04893.1 - 5.9e-152 506.3 0.0 4.8e-106 355.1 0.0 2.0 1 1 1 2 2 2 2 IMP-specific 5'-nucleotidase MerR PF00376.23 EFX04893.1 - 0.029 14.1 0.1 5.6 6.8 0.0 2.6 2 0 0 2 2 2 0 MerR family regulatory protein M20_dimer PF07687.14 EFX04895.1 - 5.4e-21 74.5 0.1 1.3e-20 73.4 0.1 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EFX04895.1 - 8.2e-10 38.7 1.1 3.7e-09 36.6 1.1 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Fungal_trans PF04082.18 EFX04895.1 - 7.1e-09 35.1 0.3 1.3e-08 34.2 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain AA_permease_2 PF13520.6 EFX04896.1 - 1.6e-52 178.8 48.0 1.9e-52 178.6 48.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX04896.1 - 2.5e-13 49.4 45.3 6.4e-13 48.1 45.3 1.5 1 1 0 1 1 1 1 Amino acid permease PT PF04886.12 EFX04897.1 - 0.059 12.9 0.5 0.1 12.1 0.5 1.3 1 0 0 1 1 1 0 PT repeat Amidase PF01425.21 EFX04898.1 - 6.8e-103 345.0 0.0 1.1e-102 344.4 0.0 1.3 1 1 0 1 1 1 1 Amidase YwqJ-deaminase PF14431.6 EFX04898.1 - 0.13 12.4 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 YwqJ-like deaminase Cuticle_1 PF08140.11 EFX04899.1 - 0.085 12.9 0.5 0.45 10.6 0.1 2.1 2 0 0 2 2 2 0 Crustacean cuticle protein repeat Methyltransf_23 PF13489.6 EFX04900.1 - 1.9e-12 47.3 0.0 2.4e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04900.1 - 6.6e-07 29.9 0.0 1.2e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04900.1 - 1.4e-05 25.8 0.0 0.00013 22.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04900.1 - 2.4e-05 24.9 0.0 6.6e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04900.1 - 0.0055 16.5 0.0 0.029 14.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX04900.1 - 0.032 13.6 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PALP PF00291.25 EFX04901.1 - 1.9e-48 165.4 0.7 2.4e-48 165.0 0.7 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme VapB_antitoxin PF09957.9 EFX04901.1 - 0.0093 15.9 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 1 Bacterial antitoxin of type II TA system, VapB Slu7 PF11708.8 EFX04902.1 - 1.3e-61 208.7 2.9 1.3e-61 208.7 2.9 1.7 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.23 EFX04902.1 - 0.00051 20.0 4.4 0.0011 19.0 4.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 EFX04902.1 - 0.014 15.1 0.5 0.059 13.1 0.8 1.8 2 0 0 2 2 2 0 Zinc knuckle Sigma70_r2 PF04542.14 EFX04902.1 - 1.7 8.4 6.3 0.1 12.4 0.7 1.8 2 0 0 2 2 2 0 Sigma-70 region 2 MFS_1 PF07690.16 EFX04904.1 - 1e-33 116.7 31.0 1e-33 116.7 31.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX04904.1 - 8.2e-12 44.7 24.0 1.1e-10 41.0 23.8 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EFX04904.1 - 5.2e-05 21.9 4.9 0.00011 20.8 4.9 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FtsX PF02687.21 EFX04904.1 - 0.064 13.7 0.6 0.064 13.7 0.6 4.3 3 1 0 4 4 4 0 FtsX-like permease family zf-C2H2_4 PF13894.6 EFX04905.1 - 0.71 10.9 3.9 7.7 7.6 0.5 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Glyco_hydro_3 PF00933.21 EFX04907.1 - 2.7e-50 171.6 0.0 4.7e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EFX04907.1 - 1.6e-47 162.1 0.0 4.3e-47 160.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EFX04907.1 - 1e-18 67.2 0.1 2.3e-18 66.0 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain WSC PF01822.19 EFX04910.1 - 3.7e-10 39.9 4.5 3.7e-10 39.9 4.5 3.4 3 0 0 3 3 3 1 WSC domain Egh16-like PF11327.8 EFX04911.1 - 2.4e-24 86.8 11.2 2.4e-24 86.8 11.2 2.5 2 1 0 2 2 2 1 Egh16-like virulence factor Pectate_lyase_3 PF12708.7 EFX04912.1 - 3.6e-18 66.2 18.7 1.8e-12 47.5 1.1 4.1 2 2 1 4 4 4 3 Pectate lyase superfamily protein DUF4246 PF14033.6 EFX04913.1 - 1e-127 427.0 0.0 4.6e-127 424.9 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF4246) Spherulin4 PF12138.8 EFX04914.1 - 1.4e-66 224.5 2.0 1.7e-66 224.3 2.0 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 Cation_ATPase_C PF00689.21 EFX04914.1 - 0.032 14.0 0.6 0.047 13.4 0.6 1.3 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus SNARE PF05739.19 EFX04914.1 - 0.053 13.5 2.0 0.11 12.5 2.0 1.5 1 0 0 1 1 1 0 SNARE domain DUF3139 PF11337.8 EFX04914.1 - 0.069 13.8 3.1 11 6.8 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) DUF1772 PF08592.11 EFX04914.1 - 0.071 13.4 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) YukC PF10140.9 EFX04914.1 - 0.2 10.5 0.3 0.29 9.9 0.3 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Synaptobrevin PF00957.21 EFX04914.1 - 1 9.2 4.8 1.9 8.3 4.8 1.4 1 0 0 1 1 1 0 Synaptobrevin NmrA PF05368.13 EFX04915.1 - 7.8e-17 61.6 0.0 1.1e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX04915.1 - 2.8e-13 50.2 0.1 6.4e-13 49.0 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EFX04915.1 - 1.8e-06 28.3 0.0 4.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFX04915.1 - 0.00026 20.5 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.22 EFX04915.1 - 0.0003 21.6 0.1 0.0005 20.9 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 EFX04915.1 - 0.00079 19.5 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EFX04915.1 - 0.0032 17.9 0.1 0.0069 16.8 0.1 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Anoct_dimer PF16178.5 EFX04915.1 - 0.021 14.6 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Ldh_1_N PF00056.23 EFX04915.1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFX04915.1 - 0.12 12.9 0.1 0.34 11.5 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_4 PF07993.12 EFX04915.1 - 0.14 11.3 0.0 0.43 9.7 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein Shikimate_DH PF01488.20 EFX04915.1 - 0.15 12.1 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GMC_oxred_N PF00732.19 EFX04917.1 - 1.7e-28 99.8 0.0 4.9e-28 98.3 0.0 1.8 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX04917.1 - 2.4e-17 63.8 0.3 4.8e-17 62.8 0.3 1.5 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFX04917.1 - 2.3e-09 36.8 0.1 0.00059 19.0 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EFX04917.1 - 3.5e-06 27.2 0.0 3.5e-06 27.2 0.0 2.4 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFX04917.1 - 7.1e-06 25.0 0.0 1.6e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EFX04917.1 - 2e-05 24.4 2.2 0.0031 17.2 0.1 3.2 2 1 0 3 3 3 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFX04917.1 - 0.00029 20.3 0.0 0.00047 19.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX04917.1 - 0.00031 20.1 0.0 0.00084 18.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX04917.1 - 0.0013 18.0 0.1 0.0027 17.0 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFX04917.1 - 0.0057 15.9 0.2 0.014 14.6 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX04917.1 - 0.014 14.5 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFX04917.1 - 0.015 14.5 0.1 0.026 13.8 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EFX04917.1 - 0.015 15.8 0.1 0.052 14.1 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX04917.1 - 0.037 13.1 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EFX04917.1 - 0.051 13.6 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding HTH_Tnp_ISL3 PF13542.6 EFX04917.1 - 0.13 11.7 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Zn_clus PF00172.18 EFX04918.1 - 2.1e-08 34.1 9.5 3.1e-08 33.6 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_2 PF12796.7 EFX04919.1 - 5.5e-33 113.4 0.3 9.6e-10 38.9 0.0 5.2 4 1 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFX04919.1 - 1.2e-24 83.7 6.5 0.0039 17.6 0.0 8.5 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFX04919.1 - 1.7e-24 85.5 5.5 1.9e-05 24.9 0.1 6.5 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EFX04919.1 - 6.1e-22 77.1 6.0 0.00084 19.7 0.1 7.7 8 0 0 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 EFX04919.1 - 5.7e-16 58.7 3.2 0.00039 20.9 0.0 5.5 5 1 2 7 7 7 3 Ankyrin repeats (many copies) F-box-like PF12937.7 EFX04919.1 - 0.0013 18.5 1.5 0.002 18.0 0.5 1.8 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 EFX04919.1 - 0.02 14.7 0.1 0.039 13.8 0.1 1.4 1 0 0 1 1 1 0 F-box F-box PF00646.33 EFX04919.1 - 0.044 13.7 0.3 0.088 12.7 0.3 1.4 1 0 0 1 1 1 0 F-box domain SipA PF09052.10 EFX04919.1 - 0.096 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 SipA N-terminal domain FAD_binding_4 PF01565.23 EFX04920.1 - 3.8e-19 68.8 1.0 5.8e-19 68.2 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain Nitroreductase PF00881.24 EFX04922.1 - 5.8e-21 75.3 1.0 2.2e-20 73.4 1.0 1.9 1 1 0 1 1 1 1 Nitroreductase family 2OG-FeII_Oxy_3 PF13640.6 EFX04922.1 - 9.1e-09 36.1 0.0 2e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TM1586_NiRdase PF14512.6 EFX04922.1 - 0.00087 18.9 0.0 0.93 9.0 0.0 2.2 2 0 0 2 2 2 2 Putative TM nitroreductase BTB PF00651.31 EFX04923.1 - 0.0082 16.4 0.0 0.1 12.8 0.0 2.4 2 1 0 2 2 2 1 BTB/POZ domain DIOX_N PF14226.6 EFX04924.1 - 7.2e-25 88.0 0.0 1.2e-24 87.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX04924.1 - 8.4e-19 67.9 0.0 1.6e-18 67.0 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EFX04925.1 - 0.03 13.3 0.0 0.03 13.3 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Nup88 PF10168.9 EFX04925.1 - 0.15 9.8 0.1 0.18 9.6 0.1 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF2206 PF09971.9 EFX04926.1 - 0.04 12.7 1.1 0.057 12.2 1.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) EAF PF09816.9 EFX04927.1 - 1.2e-21 77.0 0.3 3.5e-21 75.5 0.3 1.9 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Oxidored_FMN PF00724.20 EFX04928.1 - 1.7e-83 280.8 0.0 1.3e-82 277.8 0.0 1.9 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family NAD_binding_8 PF13450.6 EFX04929.1 - 1.1e-11 44.8 0.1 2.3e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFX04929.1 - 1.1e-08 34.8 0.0 1.1e-07 31.6 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EFX04929.1 - 4.6e-08 32.8 0.0 1.8e-07 30.9 0.0 1.6 1 1 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.24 EFX04929.1 - 7.9e-07 29.0 0.0 2.6e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX04929.1 - 1.7e-06 27.4 0.2 8.6e-06 25.1 0.1 2.1 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 EFX04929.1 - 2.7e-05 23.0 0.1 2.7e-05 23.0 0.1 1.8 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_2 PF07992.14 EFX04929.1 - 4.2e-05 22.9 0.0 7.6e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX04929.1 - 0.0033 16.7 0.0 0.0059 15.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 EFX04929.1 - 0.0052 15.9 0.2 0.0077 15.3 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EFX04929.1 - 0.0097 16.4 0.0 0.025 15.1 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFX04929.1 - 0.013 14.6 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EFX04929.1 - 0.081 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EFX04929.1 - 0.083 12.5 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.6 EFX04929.1 - 0.1 12.6 1.1 0.51 10.3 0.1 2.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EFX04929.1 - 0.11 11.8 0.0 0.25 10.6 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain HypA PF01155.19 EFX04930.1 - 0.029 14.4 0.1 0.066 13.2 0.1 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 EFX04930.1 - 0.1 12.3 3.2 0.33 10.7 3.2 1.9 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EFX04930.1 - 0.24 11.6 4.8 0.24 11.5 2.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain Iso_dh PF00180.20 EFX04931.1 - 2.1e-84 283.7 0.0 2.3e-84 283.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DoxX_2 PF13564.6 EFX04931.1 - 0.02 15.0 0.9 0.049 13.7 0.9 1.6 1 0 0 1 1 1 0 DoxX-like family PhyH PF05721.13 EFX04932.1 - 1.3e-20 74.6 0.0 1.8e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFX04933.1 - 7.7e-114 380.7 0.0 9.1e-114 380.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 EFX04933.1 - 0.0078 16.5 0.1 0.91 9.7 0.2 2.8 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) PhyH PF05721.13 EFX04934.1 - 4.9e-14 53.1 0.1 5e-13 49.8 0.1 2.0 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) ANTH PF07651.16 EFX04935.1 - 5.9e-76 255.1 0.9 2e-75 253.4 0.0 2.2 2 0 0 2 2 2 1 ANTH domain I_LWEQ PF01608.17 EFX04935.1 - 1e-49 168.7 5.8 1e-49 168.7 5.8 6.1 3 2 1 6 6 6 2 I/LWEQ domain TcdB_N PF12918.7 EFX04935.1 - 0.059 13.7 0.2 0.26 11.6 0.2 2.2 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Gpr1_Fun34_YaaH PF01184.19 EFX04936.1 - 5.8e-34 117.5 23.9 7.4e-34 117.2 23.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family PhyH PF05721.13 EFX04937.1 - 4.2e-29 102.3 0.0 6.6e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) IBN_N PF03810.19 EFX04938.1 - 1.3e-15 57.0 0.4 8.3e-12 44.9 0.0 4.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cse1 PF08506.10 EFX04938.1 - 1e-06 27.8 0.0 1.2e-05 24.3 0.0 2.4 2 1 0 2 2 2 1 Cse1 Xpo1 PF08389.12 EFX04938.1 - 0.00032 20.8 1.3 0.026 14.6 0.0 3.8 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 EFX04938.1 - 0.077 13.3 0.1 1.1 9.6 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat TerB PF05099.13 EFX04938.1 - 0.1 12.5 5.7 2.2 8.2 0.0 3.2 3 0 0 3 3 3 0 Tellurite resistance protein TerB Cnd1 PF12717.7 EFX04938.1 - 0.22 11.5 1.3 0.5 10.4 0.2 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Acetyltransf_1 PF00583.25 EFX04939.1 - 1.2e-11 44.9 0.1 1.5e-11 44.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX04939.1 - 1.1e-08 35.4 0.4 1.6e-08 34.8 0.4 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFX04939.1 - 2.4e-07 30.8 0.1 3.2e-07 30.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AstA PF04958.12 EFX04939.1 - 0.14 10.7 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit FUSC PF04632.12 EFX04940.1 - 0.21 10.1 1.5 0.23 10.0 1.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family 4HBT_3 PF13622.6 EFX04941.1 - 1.4e-49 169.6 1.3 1.6e-49 169.4 1.3 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Cep3 PF16846.5 EFX04942.1 - 7.5e-08 31.3 0.0 1.1e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Fungal_trans PF04082.18 EFX04942.1 - 5.4e-07 28.9 0.3 8.4e-07 28.3 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04942.1 - 0.002 18.2 2.7 0.004 17.2 2.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallophos PF00149.28 EFX04943.1 - 4e-28 99.3 0.8 6.3e-28 98.7 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFX04943.1 - 5.5e-13 49.3 0.5 5.5e-13 49.3 0.5 2.8 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFX04943.1 - 5.3e-12 46.4 2.1 2.7e-11 44.1 0.2 3.0 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C PhoD_N PF16655.5 EFX04943.1 - 0.0099 16.4 0.1 0.026 15.0 0.1 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain fn3 PF00041.21 EFX04943.1 - 0.024 15.0 0.0 0.075 13.4 0.0 1.8 1 0 0 1 1 1 0 Fibronectin type III domain DUF2369 PF10179.9 EFX04943.1 - 0.047 14.1 0.7 0.13 12.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) GAT PF03127.14 EFX04944.1 - 4e-10 39.9 0.0 9e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 EFX04944.1 - 6e-06 26.2 0.1 1e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 VHS domain Kelch_3 PF13415.6 EFX04944.1 - 5.4 7.4 7.9 21 5.5 3.4 3.7 3 1 0 3 3 3 0 Galactose oxidase, central domain Dynamin_N PF00350.23 EFX04945.1 - 4.5e-33 114.7 0.0 9.6e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFX04945.1 - 5e-27 94.9 0.0 2.6e-26 92.5 0.0 2.0 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EFX04945.1 - 0.00073 19.6 0.2 0.014 15.5 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Abhydrolase_6 PF12697.7 EFX04945.1 - 0.016 15.8 8.4 0.024 15.3 6.5 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family AAA_16 PF13191.6 EFX04945.1 - 0.026 14.9 3.5 0.64 10.4 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain GED PF02212.18 EFX04945.1 - 0.16 12.2 0.8 0.6 10.3 0.1 2.2 2 0 0 2 2 2 0 Dynamin GTPase effector domain FeoB_N PF02421.18 EFX04945.1 - 0.16 11.5 0.0 26 4.3 0.0 2.6 3 0 0 3 3 3 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFX04945.1 - 0.16 11.8 0.1 23 4.9 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase N_formyltrans_C PF18216.1 EFX04946.1 - 0.15 11.8 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain ABC_membrane PF00664.23 EFX04947.1 - 4.4e-28 98.7 30.1 8.3e-21 74.8 11.8 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFX04947.1 - 5.5e-19 69.1 0.0 1.7e-14 54.5 0.0 3.2 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFX04947.1 - 4.3e-06 26.3 0.0 0.31 10.5 0.0 3.1 2 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFX04947.1 - 0.0029 17.5 0.1 2.2 8.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFX04947.1 - 0.067 13.5 0.0 0.56 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFX04947.1 - 0.12 12.8 0.0 2.2 8.7 0.0 2.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 EFX04947.1 - 0.17 11.6 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 EFX04947.1 - 0.2 12.1 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AA_permease PF00324.21 EFX04948.1 - 3.4e-115 385.4 43.0 4e-115 385.1 43.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX04948.1 - 1.3e-36 126.3 43.9 1.7e-36 126.0 43.9 1.2 1 0 0 1 1 1 1 Amino acid permease DHHC PF01529.20 EFX04948.1 - 0.25 11.5 0.1 0.25 11.5 0.1 4.2 3 1 1 4 4 4 0 DHHC palmitoyltransferase Phage_holin_1 PF04531.13 EFX04948.1 - 3 8.4 8.1 4.7 7.8 0.1 2.9 3 0 0 3 3 3 0 Bacteriophage holin Med26 PF08711.11 EFX04949.1 - 6.6e-11 42.1 0.0 1.5e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Exo_endo_phos PF03372.23 EFX04950.1 - 4.1e-18 65.7 3.7 9.8e-18 64.5 3.7 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EFX04950.1 - 9e-07 28.9 3.3 2.2e-06 27.7 3.3 1.7 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 EFX04950.1 - 0.00071 19.4 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase zf-RING_2 PF13639.6 EFX04951.1 - 2.1e-13 50.4 5.1 3.8e-13 49.5 5.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFX04951.1 - 3.3e-09 36.3 2.2 3.3e-09 36.3 2.2 2.0 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.22 EFX04951.1 - 4.9e-09 36.1 1.7 1.2e-08 34.9 0.3 2.4 2 1 0 2 2 2 1 PA domain zf-C3HC4_2 PF13923.6 EFX04951.1 - 1.8e-08 34.1 3.8 1.8e-08 34.1 3.8 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFX04951.1 - 6.2e-08 32.8 2.5 1.2e-07 31.9 2.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFX04951.1 - 8.6e-08 31.9 2.9 1.6e-07 31.0 2.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX04951.1 - 9.3e-07 28.7 1.9 1.6e-06 27.9 1.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFX04951.1 - 8.4e-06 25.7 2.0 8.8e-05 22.4 2.7 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFX04951.1 - 1.1e-05 25.2 2.5 2e-05 24.3 2.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFX04951.1 - 0.0011 19.0 0.8 0.0023 17.9 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EFX04951.1 - 0.0037 16.8 2.5 0.0075 15.9 2.5 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EFX04951.1 - 0.01 15.7 2.9 0.017 15.0 2.9 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFX04951.1 - 0.026 14.7 2.6 0.061 13.5 2.6 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING CitMHS PF03600.16 EFX04951.1 - 0.13 11.4 2.1 0.13 11.4 0.1 1.9 2 0 0 2 2 2 0 Citrate transporter PHD PF00628.29 EFX04951.1 - 0.28 11.1 1.9 0.49 10.3 1.9 1.4 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 EFX04951.1 - 0.31 11.2 3.2 0.55 10.4 3.2 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EFX04951.1 - 0.35 11.1 2.7 1.2 9.4 2.7 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 EFX04951.1 - 0.55 10.6 2.2 1 9.7 2.2 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 EFX04951.1 - 1.3 8.8 3.0 2.5 8.0 3.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Ribonuc_L-PSP PF01042.21 EFX04952.1 - 8.4e-14 51.6 0.1 9.9e-14 51.4 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Atg29_N PF18388.1 EFX04953.1 - 2.2e-25 88.2 0.7 4.4e-25 87.3 0.7 1.5 1 0 0 1 1 1 1 Atg29 N-terminal domain Pkinase PF00069.25 EFX04955.1 - 1.1e-45 156.1 0.0 2.2e-45 155.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04955.1 - 2.3e-24 86.1 0.0 6e-23 81.5 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX04955.1 - 0.0027 16.6 0.1 0.0056 15.5 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFX04955.1 - 0.0033 17.1 0.2 0.061 12.9 0.1 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Fungal_trans PF04082.18 EFX04956.1 - 1.6e-07 30.6 0.0 3.2e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2304 PF10066.9 EFX04956.1 - 0.065 13.5 0.4 0.065 13.5 0.4 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Imp-YgjV PF10688.9 EFX04956.1 - 0.15 11.9 2.6 0.45 10.3 2.6 1.8 1 0 0 1 1 1 0 Bacterial inner membrane protein zf-CCCH PF00642.24 EFX04957.1 - 3e-05 23.8 15.6 0.003 17.4 0.6 3.1 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFX04957.1 - 0.0048 17.6 5.7 0.55 11.0 0.0 2.9 3 0 0 3 3 3 2 Torus domain Collagen PF01391.18 EFX04957.1 - 0.016 15.0 2.3 0.041 13.7 2.3 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) zf_CCCH_4 PF18345.1 EFX04957.1 - 2.3 8.4 17.3 1.1 9.4 2.0 3.3 3 0 0 3 3 3 0 Zinc finger domain ARPC4 PF05856.12 EFX04958.1 - 3.2e-78 261.1 4.0 3.6e-78 260.9 4.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) O-FucT PF10250.9 EFX04959.1 - 2.4e-09 37.4 1.9 4.6e-08 33.1 1.9 2.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Pkinase PF00069.25 EFX04960.1 - 9.8e-43 146.4 0.0 2.3e-42 145.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX04960.1 - 1.7e-17 63.5 0.0 4.5e-16 58.9 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX04960.1 - 0.021 14.2 0.9 1.8 7.8 0.0 2.7 3 0 0 3 3 3 0 Kinase-like DUF1100 PF06500.11 EFX04961.1 - 9e-12 44.5 0.0 1.2e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S15 PF02129.18 EFX04961.1 - 1.5e-06 28.1 0.1 2.7e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EFX04961.1 - 0.00018 21.2 0.1 0.00059 19.6 0.1 1.8 1 1 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 EFX04961.1 - 0.0011 18.7 0.1 0.37 10.4 0.3 2.5 1 1 1 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX04961.1 - 0.0019 17.7 0.4 0.019 14.4 0.4 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFX04961.1 - 0.0098 15.2 0.0 0.91 8.7 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Plasmod_dom_1 PF09715.10 EFX04961.1 - 0.17 12.0 0.0 0.52 10.4 0.0 1.7 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) EcKinase PF02958.20 EFX04963.1 - 1.3e-16 60.8 0.0 1.1e-14 54.4 0.0 2.1 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 EFX04963.1 - 4.1e-10 40.0 0.2 6.1e-10 39.4 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFX04963.1 - 9e-08 31.4 0.0 1.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) NAD_binding_10 PF13460.6 EFX04964.1 - 7.4e-10 39.0 0.0 2.5e-09 37.3 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EFX04964.1 - 5.3e-06 26.1 0.0 1.1e-05 25.1 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family F420_oxidored PF03807.17 EFX04964.1 - 0.0004 20.9 0.0 0.0066 17.0 0.0 2.5 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 EFX04964.1 - 0.0011 19.4 0.0 0.01 16.3 0.0 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding Epimerase PF01370.21 EFX04964.1 - 0.0018 17.8 0.0 0.13 11.7 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family LpxI_N PF17930.1 EFX04964.1 - 0.0032 17.4 0.0 0.069 13.0 0.0 2.3 2 0 0 2 2 2 1 LpxI N-terminal domain TrkA_N PF02254.18 EFX04964.1 - 0.018 15.3 0.1 0.076 13.3 0.1 2.1 1 1 0 1 1 1 0 TrkA-N domain GDP_Man_Dehyd PF16363.5 EFX04964.1 - 0.018 14.5 0.0 2 7.7 0.0 2.4 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 EFX04964.1 - 0.031 14.3 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EFX04964.1 - 0.15 12.3 0.1 0.44 10.8 0.1 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AhpC-TSA PF00578.21 EFX04965.1 - 5.8e-36 123.1 0.0 8e-36 122.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFX04965.1 - 1.1e-13 51.2 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFX04965.1 - 1.4e-11 44.1 0.1 3.4e-11 42.8 0.0 1.7 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin RNA_pol_Rpc82 PF05645.13 EFX04966.1 - 0.02 14.7 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 adh_short PF00106.25 EFX04966.1 - 0.044 13.2 0.1 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 short chain dehydrogenase Bac_luciferase PF00296.20 EFX04967.1 - 1.4e-54 185.7 0.4 2.3e-54 185.0 0.4 1.4 1 1 0 1 1 1 1 Luciferase-like monooxygenase AATase PF07247.12 EFX04968.1 - 2.6e-09 36.2 0.1 1.3e-05 24.0 0.0 2.1 2 0 0 2 2 2 2 Alcohol acetyltransferase Lipase_3 PF01764.25 EFX04969.1 - 8e-15 55.0 0.0 2e-13 50.4 0.0 2.3 1 1 0 1 1 1 1 Lipase (class 3) ADH_N PF08240.12 EFX04969.1 - 1.1e-12 47.8 3.1 1.7e-12 47.2 0.8 2.3 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain FrhB_FdhB_N PF04422.13 EFX04969.1 - 0.097 12.8 0.0 0.27 11.4 0.0 1.8 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term TOBE_2 PF08402.10 EFX04969.1 - 0.16 12.1 4.1 10 6.3 0.0 4.2 3 1 1 4 4 4 0 TOBE domain AIRC PF00731.20 EFX04970.1 - 4.1e-60 201.7 0.8 4.1e-60 201.7 0.8 2.0 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.22 EFX04970.1 - 1e-44 152.2 0.0 5.7e-44 149.7 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain PurK_C PF17769.1 EFX04970.1 - 1.6e-14 53.3 0.2 3.2e-14 52.3 0.2 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 EFX04970.1 - 0.0082 15.7 0.0 0.055 13.0 0.0 2.4 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus PrpR_N PF06506.11 EFX04970.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 Propionate catabolism activator Sugar_tr PF00083.24 EFX04971.1 - 3.5e-67 227.2 23.3 4e-67 227.0 23.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX04971.1 - 9.6e-20 70.8 46.6 2.1e-17 63.1 31.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2892 PF11127.8 EFX04971.1 - 0.011 15.7 2.4 0.011 15.7 2.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) DUF4395 PF14340.6 EFX04971.1 - 5.2 7.4 11.4 0.29 11.5 4.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4395) Tower PF09121.10 EFX04973.1 - 0.49 10.6 3.1 0.34 11.1 0.7 2.0 2 0 0 2 2 2 0 Tower Nop14 PF04147.12 EFX04974.1 - 0.0012 17.2 41.4 0.0017 16.6 41.4 1.2 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.10 EFX04974.1 - 0.0097 15.3 33.1 0.017 14.5 33.1 1.5 1 0 0 1 1 1 1 BUD22 CDC27 PF09507.10 EFX04974.1 - 0.84 9.0 27.0 1.6 8.0 27.0 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 EFX04974.1 - 5.8 5.6 15.0 10 4.8 15.0 1.4 1 0 0 1 1 1 0 Presenilin Transket_pyr PF02779.24 EFX04975.1 - 1.6e-46 158.2 0.0 2.1e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFX04975.1 - 1.8e-37 128.0 0.2 1e-36 125.5 0.0 2.2 3 0 0 3 3 3 1 Transketolase, C-terminal domain AA_permease PF00324.21 EFX04976.1 - 4.9e-108 361.8 45.8 6e-108 361.5 45.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX04976.1 - 1.3e-27 96.8 47.3 1.6e-27 96.4 47.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1612 PF07756.12 EFX04976.1 - 0.23 11.7 1.7 15 5.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) RRM_1 PF00076.22 EFX04977.1 - 1.4e-08 34.4 0.0 2.6e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFX04977.1 - 0.00059 19.8 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFX04977.1 - 0.0019 18.0 0.0 0.0029 17.4 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EFX04977.1 - 0.012 15.6 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif Tyrosinase PF00264.20 EFX04978.1 - 1.1e-48 166.5 0.0 1.4e-48 166.1 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase CFEM PF05730.11 EFX04979.1 - 3.4e-06 27.0 16.4 3.4e-06 27.0 16.4 2.3 2 1 1 3 3 3 1 CFEM domain Borrelia_rep PF03183.13 EFX04979.1 - 1.9 8.6 5.8 7.7 6.7 5.8 2.1 1 0 0 1 1 1 0 Borrelia repeat protein ADH_zinc_N PF00107.26 EFX04980.1 - 2e-23 82.8 0.2 3e-23 82.2 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX04980.1 - 8.3e-20 70.7 1.1 1.6e-19 69.7 1.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF1993 PF09351.10 EFX04981.1 - 3.8e-53 179.9 0.1 4.3e-53 179.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DUF3155 PF11352.8 EFX04981.1 - 0.17 12.4 0.0 0.27 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3155) Methyltransf_23 PF13489.6 EFX04982.1 - 4.3e-19 68.9 0.0 6.7e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX04982.1 - 1e-09 38.9 0.0 2.4e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX04982.1 - 3.1e-09 36.8 0.0 1.5e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX04982.1 - 4.7e-09 36.9 0.0 3.2e-08 34.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX04982.1 - 5.7e-08 33.3 0.0 1.5e-07 31.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFX04982.1 - 0.0049 16.4 0.0 0.011 15.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EFX04982.1 - 0.0064 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 EFX04982.1 - 0.022 14.9 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 EFX04982.1 - 0.029 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EFX04982.1 - 0.033 13.7 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase PX PF00787.24 EFX04983.1 - 3.4e-25 88.2 0.0 4.9e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 PX domain Fungal_trans_2 PF11951.8 EFX04986.1 - 6.8e-50 170.0 8.0 8.5e-50 169.7 8.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04986.1 - 5.6e-06 26.4 7.6 1.3e-05 25.2 7.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SnoaL_4 PF13577.6 EFX04987.1 - 3.2e-17 62.9 0.3 9e-17 61.4 0.0 2.0 3 0 0 3 3 3 1 SnoaL-like domain Fungal_trans PF04082.18 EFX04987.1 - 0.0081 15.2 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidase_2 PF01510.25 EFX04988.1 - 5.7e-11 43.0 0.0 1.1e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase PG_binding_1 PF01471.18 EFX04988.1 - 1e-05 25.6 0.0 1.8e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.10 EFX04988.1 - 0.00038 20.7 0.0 0.00088 19.5 0.0 1.6 1 0 0 1 1 1 1 Predicted Peptidoglycan domain Autophagy_N PF03986.13 EFX04991.1 - 3e-44 150.3 0.4 8.5e-44 148.8 0.0 1.9 2 1 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EFX04991.1 - 2.6e-15 56.7 0.1 4.7e-15 55.9 0.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EFX04991.1 - 5.4e-07 29.0 0.7 1.5e-06 27.5 0.7 1.8 1 1 0 1 1 1 1 Autophagocytosis associated protein C-terminal CENP-B_dimeris PF09026.10 EFX04991.1 - 0.68 10.4 15.1 0.091 13.2 9.8 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FA_desaturase PF00487.24 EFX04992.1 - 3.5e-27 95.9 30.6 5.5e-27 95.2 30.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EFX04992.1 - 5.7e-07 29.8 0.0 9.5e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Fungal_trans PF04082.18 EFX04993.1 - 4.8e-16 58.6 1.0 1.6e-15 56.9 0.3 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX04993.1 - 2.6e-05 24.3 13.4 5.1e-05 23.3 13.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EFX04994.1 - 4.5e-29 101.3 0.0 7.9e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX04994.1 - 7e-29 101.0 0.1 1.9e-28 99.6 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX04994.1 - 0.019 14.9 0.1 0.03 14.2 0.1 1.3 1 0 0 1 1 1 0 KR domain Pyr_redox_3 PF13738.6 EFX04994.1 - 0.11 11.7 0.0 1 8.5 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX04994.1 - 0.13 11.4 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EFX04995.1 - 8.8e-28 97.2 32.3 1.5e-27 96.5 32.3 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily ADH_N PF08240.12 EFX04995.1 - 4.8e-25 87.6 1.8 9.4e-25 86.6 1.8 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX04995.1 - 2.9e-23 82.3 0.1 6.6e-23 81.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX04995.1 - 7.5e-07 28.8 0.1 1.4e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFX04995.1 - 0.00055 21.0 0.0 0.0013 19.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 EFX04995.1 - 0.00068 20.0 2.1 0.024 15.1 0.4 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EFX04995.1 - 0.0028 16.9 0.2 0.0028 16.9 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain ADH_N_assoc PF13823.6 EFX04995.1 - 0.0046 16.8 0.0 0.0086 16.0 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Pyr_redox_3 PF13738.6 EFX04995.1 - 0.047 12.9 0.5 0.083 12.1 0.5 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX04995.1 - 0.058 12.5 2.3 0.099 11.7 2.3 1.3 1 0 0 1 1 1 0 FAD binding domain DUF2649 PF10854.8 EFX04995.1 - 2.8 8.3 4.2 1.3 9.4 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2649) FAD_binding_3 PF01494.19 EFX04996.1 - 9.5e-21 74.4 1.1 1.3e-13 51.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.14 EFX04996.1 - 5.5e-07 28.8 4.8 0.0027 16.6 0.2 2.1 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 EFX04996.1 - 0.00033 20.0 2.7 0.0066 15.7 0.8 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX04996.1 - 0.00052 20.2 1.5 0.00052 20.2 1.5 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFX04996.1 - 0.00085 18.8 0.5 0.0013 18.2 0.5 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX04996.1 - 0.0023 17.1 6.2 0.0023 17.1 6.2 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EFX04996.1 - 0.0055 15.5 4.1 0.012 14.4 2.6 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFX04996.1 - 0.0074 15.9 11.1 0.76 9.3 7.4 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 EFX04996.1 - 0.048 12.7 5.2 0.087 11.9 5.2 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX04996.1 - 0.051 12.6 5.8 0.21 10.6 5.9 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EFX04996.1 - 0.053 12.8 0.5 0.089 12.0 0.5 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EFX04996.1 - 0.072 12.4 3.5 3.5 6.8 0.8 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Methyltransf_16 PF10294.9 EFX04996.1 - 0.26 11.0 0.5 0.44 10.3 0.1 1.6 2 0 0 2 2 1 0 Lysine methyltransferase 3HCDH_N PF02737.18 EFX04996.1 - 0.28 11.1 3.4 0.53 10.2 3.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFX04996.1 - 0.37 11.4 5.1 0.36 11.4 3.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Bac_rhamnosid6H PF17389.2 EFX04997.1 - 5.9e-18 65.2 0.6 9.8e-16 57.9 0.1 2.3 1 1 1 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_36 PF17167.4 EFX04997.1 - 0.031 13.0 0.1 0.094 11.4 0.1 1.8 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain Bac_rhamnosid PF05592.11 EFX04997.1 - 0.075 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain Spherulin4 PF12138.8 EFX04998.1 - 4.6e-56 190.1 0.0 5.4e-56 189.9 0.0 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 DIOX_N PF14226.6 EFX04999.1 - 3.3e-29 102.0 0.0 4.7e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX04999.1 - 8e-23 80.8 0.0 2.7e-22 79.2 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily adh_short_C2 PF13561.6 EFX05000.1 - 2.5e-49 168.0 0.1 3.1e-49 167.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX05000.1 - 3.4e-46 157.2 0.1 4.4e-46 156.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX05000.1 - 4.4e-09 36.5 0.9 8.9e-09 35.5 0.9 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX05000.1 - 0.013 15.0 0.7 0.063 12.7 0.7 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EFX05000.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Peptidase_M20 PF01546.28 EFX05001.1 - 5.5e-28 98.1 0.4 8.4e-28 97.5 0.1 1.5 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX05001.1 - 7.2e-18 64.5 0.1 1.3e-17 63.6 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFX05001.1 - 2.6e-06 27.3 0.0 9e-06 25.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 AA_permease PF00324.21 EFX05002.1 - 4e-88 296.1 33.8 4.5e-88 296.0 33.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX05002.1 - 4.6e-32 111.4 36.4 6e-32 111.0 36.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2157 PF09925.9 EFX05002.1 - 2.9 7.7 8.3 16 5.3 1.0 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) Pec_lyase_C PF00544.19 EFX05003.1 - 6.6e-43 146.7 10.1 9.4e-43 146.2 10.1 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EFX05003.1 - 3.8e-05 23.6 17.5 0.0014 18.5 5.3 2.3 1 1 1 2 2 2 2 Right handed beta helix region CAMSAP_CC1 PF17095.5 EFX05004.1 - 0.12 12.2 2.5 0.3 11.0 2.5 1.6 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin DUF829 PF05705.14 EFX05005.1 - 2e-53 181.8 0.0 2.3e-53 181.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Na_H_Exchanger PF00999.21 EFX05006.1 - 7.1e-19 67.8 46.2 2.9e-17 62.6 33.2 3.7 2 1 0 2 2 2 2 Sodium/hydrogen exchanger family Isochorismatase PF00857.20 EFX05007.1 - 4.6e-47 160.4 0.0 5.4e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family zf-CCCH PF00642.24 EFX05009.1 - 8.6e-08 31.9 1.7 1.7e-07 31.0 1.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EFX05009.1 - 1.1e-07 31.6 5.9 1.7e-07 31.0 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFX05009.1 - 4.8e-07 29.5 6.8 8.2e-07 28.8 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX05009.1 - 7.2e-07 29.0 7.6 1.2e-06 28.3 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFX05009.1 - 7.5e-07 29.1 4.7 1.7e-06 27.9 4.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFX05009.1 - 1.1e-06 28.5 8.1 1.7e-06 27.8 8.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EFX05009.1 - 2.8e-05 24.2 3.4 5.7e-05 23.2 3.4 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf_CCCH_4 PF18345.1 EFX05009.1 - 5.6e-05 23.1 4.9 0.0001 22.2 4.9 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_2 PF13639.6 EFX05009.1 - 9.9e-05 22.6 6.9 0.00018 21.8 6.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-CCCH_4 PF18044.1 EFX05009.1 - 0.00018 21.2 2.2 0.00018 21.2 2.2 1.9 2 0 0 2 2 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 EFX05009.1 - 0.00044 20.4 4.7 0.0011 19.1 4.7 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFX05009.1 - 0.0011 18.7 5.1 0.0021 17.9 5.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Cript PF10235.9 EFX05009.1 - 0.08 13.5 1.7 0.2 12.2 1.7 1.8 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT zf-CCCH_2 PF14608.6 EFX05009.1 - 0.17 12.4 3.2 0.32 11.5 3.2 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-rbx1 PF12678.7 EFX05009.1 - 0.28 11.5 3.0 0.65 10.3 3.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF4719 PF15843.5 EFX05009.1 - 3.6 7.6 7.8 0.45 10.6 0.8 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4719) AA_permease_2 PF13520.6 EFX05011.1 - 1e-62 212.4 47.6 1.4e-62 211.9 47.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX05011.1 - 9.4e-22 77.2 37.9 1.2e-21 76.8 37.9 1.0 1 0 0 1 1 1 1 Amino acid permease HeLo PF14479.6 EFX05012.1 - 5.4e-36 124.4 5.4 6.6e-36 124.1 5.4 1.1 1 0 0 1 1 1 1 Prion-inhibition and propagation HET-s_218-289 PF11558.8 EFX05012.1 - 5.7e-22 77.5 1.0 1.2e-21 76.5 0.4 1.9 2 0 0 2 2 2 1 Het-s 218-289 YkyA PF10368.9 EFX05012.1 - 0.22 11.2 2.9 0.2 11.3 0.4 1.8 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Ead_Ea22 PF13935.6 EFX05012.1 - 0.23 12.1 6.4 0.29 11.8 3.8 2.1 1 1 1 2 2 2 0 Ead/Ea22-like protein dCMP_cyt_deam_1 PF00383.23 EFX05013.1 - 3.3e-21 75.0 0.0 1.1e-20 73.4 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFX05013.1 - 4.1e-16 59.0 0.1 4.1e-07 29.8 0.0 2.4 2 0 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 EFX05013.1 - 5.1e-05 23.4 2.9 0.087 12.9 0.1 2.5 2 0 0 2 2 2 2 Bd3614-like deaminase PMT PF02366.18 EFX05014.1 - 4.4e-78 262.2 14.8 9.7e-78 261.1 14.8 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EFX05014.1 - 1.8e-66 223.6 9.2 1.8e-66 223.6 9.2 2.3 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EFX05014.1 - 4e-42 144.2 0.0 7.1e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 MIR domain Peptidase_M19 PF01244.21 EFX05015.1 - 8.2e-110 366.9 0.0 1e-109 366.6 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) UCH PF00443.29 EFX05016.1 - 1.3e-48 165.7 0.0 1.7e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFX05016.1 - 1.5e-14 54.3 3.6 6.7e-14 52.2 3.6 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFX05016.1 - 6.6e-05 22.6 0.1 6.6e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin family SR-25 PF10500.9 EFX05016.1 - 0.0072 16.0 11.1 0.0072 16.0 11.1 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein XRN_M PF17846.1 EFX05016.1 - 0.44 9.5 2.1 0.78 8.6 2.1 1.3 1 0 0 1 1 1 0 Xrn1 helical domain ASD2 PF08687.11 EFX05016.1 - 0.51 9.8 6.2 0.2 11.2 3.2 1.7 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Secretin_N_2 PF07655.13 EFX05016.1 - 2.1 9.0 10.7 1.7 9.2 3.3 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain Vfa1 PF08432.10 EFX05016.1 - 2.8 8.2 10.5 0.19 12.0 5.1 1.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Period_C PF12114.8 EFX05016.1 - 5.5 6.5 14.2 1 8.9 6.1 2.3 2 0 0 2 2 2 0 Period protein 2/3C-terminal region tRNA_synt_1c_R2 PF04557.15 EFX05016.1 - 5.7 7.9 7.0 19 6.2 7.0 1.9 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF917 PF06032.12 EFX05017.1 - 8.9e-125 416.1 0.6 8.9e-125 416.1 0.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 EFX05017.1 - 1.2e-29 103.2 0.2 6.8e-27 94.3 0.0 2.9 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EFX05017.1 - 4.1e-28 98.5 6.3 1.6e-24 86.7 1.2 3.2 2 1 0 3 3 3 2 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 EFX05017.1 - 5.4e-05 22.8 7.9 0.0015 18.1 0.2 3.0 3 0 0 3 3 3 2 BadF/BadG/BcrA/BcrD ATPase family MutL PF13941.6 EFX05017.1 - 0.00062 18.5 0.6 0.064 11.8 0.0 2.4 2 0 0 2 2 2 2 MutL protein ROK PF00480.20 EFX05017.1 - 0.0014 18.2 0.4 0.0067 15.9 0.1 2.4 2 0 0 2 2 2 1 ROK family StbA PF06406.11 EFX05017.1 - 0.017 14.4 0.5 1.9 7.7 0.2 2.2 2 0 0 2 2 2 0 StbA protein FtsA PF14450.6 EFX05017.1 - 0.25 11.8 0.9 29 5.2 0.0 3.4 3 0 0 3 3 3 0 Cell division protein FtsA Oxidored_FMN PF00724.20 EFX05018.1 - 2e-49 168.7 0.0 9.6e-38 130.3 0.0 2.0 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family RST PF12174.8 EFX05018.1 - 0.22 11.5 0.0 0.39 10.7 0.0 1.3 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain adh_short_C2 PF13561.6 EFX05019.1 - 1.3e-52 178.7 0.6 1.6e-52 178.4 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX05019.1 - 2.2e-45 154.5 0.4 3e-45 154.1 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX05019.1 - 4.1e-12 46.4 1.9 7.2e-12 45.6 1.9 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX05019.1 - 0.03 13.8 0.1 0.038 13.4 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family COX6A PF02046.15 EFX05020.1 - 4e-50 169.0 0.1 4.9e-50 168.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa zf-CCCH PF00642.24 EFX05021.1 - 7.7e-08 32.1 16.8 2.9e-05 23.9 5.7 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFX05021.1 - 8.9e-08 32.0 26.9 3e-05 23.9 8.4 2.9 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 EFX05021.1 - 1.6e-06 27.7 28.1 0.00018 21.2 7.6 3.5 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 EFX05021.1 - 0.00015 22.4 8.1 0.00053 20.6 1.2 3.0 2 1 1 3 3 2 2 Torus domain RRM_1 PF00076.22 EFX05021.1 - 0.0036 17.1 0.0 0.2 11.5 0.0 3.2 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4 PF00097.25 EFX05021.1 - 0.012 15.5 13.1 0.027 14.4 12.5 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Bet_v_1 PF00407.19 EFX05021.1 - 0.054 13.4 1.1 0.15 11.9 0.0 2.2 3 0 0 3 3 3 0 Pathogenesis-related protein Bet v I family zf-RING_UBOX PF13445.6 EFX05021.1 - 0.17 11.9 8.6 0.57 10.3 8.6 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFX05021.1 - 0.18 12.0 14.2 0.56 10.4 14.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EFX05021.1 - 0.19 11.6 11.3 0.45 10.4 11.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 PF14608.6 EFX05021.1 - 1.2 9.8 15.5 2.1 8.9 2.0 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-C3HC4_2 PF13923.6 EFX05021.1 - 3.1 7.7 13.9 0.28 11.1 8.8 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-CCCH_3 PF15663.5 EFX05021.1 - 4.4 7.5 16.4 0.09 13.0 5.0 2.7 2 1 0 2 2 2 0 Zinc-finger containing family NYN PF01936.18 EFX05022.1 - 8.2e-06 26.4 0.0 0.00025 21.6 0.0 2.3 1 1 0 1 1 1 1 NYN domain Peptidase_S66 PF02016.15 EFX05023.1 - 7.5e-26 90.6 0.0 1.4e-25 89.7 0.0 1.5 1 1 0 1 1 1 1 LD-carboxypeptidase N-terminal domain Peptidase_S66C PF17676.1 EFX05023.1 - 1.1e-08 35.6 0.0 1.9e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 LD-carboxypeptidase C-terminal domain S-methyl_trans PF02574.16 EFX05023.1 - 0.013 15.3 0.1 0.016 15.0 0.1 1.2 1 0 0 1 1 1 0 Homocysteine S-methyltransferase Metallophos PF00149.28 EFX05024.1 - 4.4e-19 69.8 0.3 6.6e-19 69.2 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFX05024.1 - 3e-16 60.0 0.2 7.9e-16 58.7 0.2 1.8 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 EFX05024.1 - 2.6e-14 53.6 0.6 7.9e-14 52.0 0.3 2.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 EFX05024.1 - 0.0068 16.9 0.0 0.018 15.6 0.0 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain DUF4267 PF14087.6 EFX05024.1 - 0.028 14.5 0.1 0.052 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) Dioxygenase_C PF00775.21 EFX05025.1 - 1.1e-39 135.8 0.0 1.4e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EFX05025.1 - 2.3e-25 88.3 0.0 3.6e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus SpaA PF17802.1 EFX05025.1 - 0.02 15.2 0.1 0.05 13.9 0.1 1.7 1 0 0 1 1 1 0 Prealbumin-like fold domain CarboxypepD_reg PF13620.6 EFX05025.1 - 0.087 13.1 0.0 0.39 11.0 0.0 2.0 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Pkinase_fungal PF17667.1 EFX05026.1 - 0.003 16.4 0.0 0.0041 15.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EFX05026.1 - 0.0031 16.9 0.0 0.004 16.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFX05026.1 - 0.018 15.0 0.0 0.043 13.7 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFX05026.1 - 0.022 14.1 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EFX05026.1 - 0.064 12.5 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Methyltransf_PK PF05891.12 EFX05027.1 - 1.2e-65 221.1 0.0 3.4e-32 111.7 0.0 2.0 2 0 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EFX05027.1 - 0.024 15.3 0.0 12 6.7 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_2 PF00891.18 EFX05027.1 - 0.11 11.7 0.0 0.34 10.2 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain MFS_1 PF07690.16 EFX05028.1 - 1.7e-32 112.7 18.0 2.8e-32 112.0 18.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05030.1 - 6.2e-82 275.9 20.4 7.1e-82 275.7 20.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05030.1 - 1.5e-31 109.7 30.4 5e-24 84.9 10.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX05030.1 - 0.00011 20.8 1.1 0.00011 20.8 1.1 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EFX05030.1 - 0.17 10.7 18.0 0.023 13.6 6.3 2.3 1 1 1 2 2 2 0 MFS_1 like family YtpI PF14007.6 EFX05030.1 - 0.45 10.7 7.6 2.8 8.2 1.5 2.9 2 0 0 2 2 2 0 YtpI-like protein SET PF00856.28 EFX05031.1 - 3e-12 47.3 0.0 7.8e-11 42.7 0.0 2.2 1 1 0 1 1 1 1 SET domain Sugar_tr PF00083.24 EFX05033.1 - 4.5e-84 282.9 26.7 5.2e-84 282.7 26.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05033.1 - 5.6e-30 104.5 32.7 3e-25 88.9 9.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFX05033.1 - 8.7e-08 31.8 3.9 8.7e-08 31.8 3.9 2.0 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EFX05033.1 - 9.9e-07 27.5 1.7 9.9e-07 27.5 1.7 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EFX05033.1 - 1.3 7.8 23.1 0.26 10.1 3.0 2.7 2 1 0 2 2 2 0 MFS_1 like family Brr6_like_C_C PF10104.9 EFX05034.1 - 6.3e-42 142.5 0.8 8.4e-42 142.1 0.8 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Fumble PF03630.14 EFX05035.1 - 7.4e-145 482.2 0.1 9.8e-145 481.8 0.1 1.1 1 0 0 1 1 1 1 Fumble TauD PF02668.16 EFX05037.1 - 1e-34 120.6 0.4 3.4e-34 118.9 0.4 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF4417 PF14386.6 EFX05037.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4417) ADH_zinc_N PF00107.26 EFX05038.1 - 1.2e-13 51.2 0.0 3.4e-13 49.7 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX05038.1 - 5.6e-09 35.8 0.1 0.00032 20.3 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFX05038.1 - 0.007 17.4 0.0 0.014 16.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TRAF6_Z2 PF18048.1 EFX05038.1 - 0.016 15.3 0.4 0.029 14.5 0.4 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 DUF960 PF06124.11 EFX05039.1 - 0.03 15.0 0.0 0.48 11.1 0.0 2.1 2 0 0 2 2 2 0 Staphylococcal protein of unknown function (DUF960) MFS_1 PF07690.16 EFX05040.1 - 2.5e-15 56.3 52.8 2.5e-13 49.7 52.8 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Pox_A14 PF05767.12 EFX05040.1 - 0.072 13.3 2.5 0.14 12.3 0.3 2.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF2254 PF10011.9 EFX05040.1 - 0.44 9.3 2.2 49 2.6 3.3 2.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2254) TauD PF02668.16 EFX05042.1 - 2.6e-30 106.1 0.2 3.1e-29 102.6 0.2 2.5 2 1 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family ATP-synt_ab_Xtn PF16886.5 EFX05042.1 - 0.12 12.2 0.0 0.81 9.6 0.0 2.1 2 0 0 2 2 2 0 ATPsynthase alpha/beta subunit N-term extension MFS_1 PF07690.16 EFX05043.1 - 1.5e-23 83.3 33.7 3.7e-16 59.0 13.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05043.1 - 2.1e-19 69.7 27.9 3.4e-17 62.5 27.9 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter OapA_N PF08525.11 EFX05043.1 - 0.19 11.7 0.5 4.7 7.3 0.8 2.6 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif Spo7 PF03907.13 EFX05043.1 - 0.26 10.7 2.1 0.44 10.0 2.1 1.3 1 0 0 1 1 1 0 Spo7-like protein DHHC PF01529.20 EFX05043.1 - 7.8 6.6 10.9 0.73 9.9 2.1 2.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF2052 PF09747.9 EFX05044.1 - 4.5e-16 59.6 15.4 4.5e-14 53.1 15.4 2.4 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) LPMO_10 PF03067.15 EFX05046.1 - 6.2e-11 43.3 0.6 1.3e-10 42.3 0.6 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading zf-C2HC_2 PF13913.6 EFX05048.1 - 0.0046 16.8 3.4 0.56 10.2 0.5 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type CpXC PF14353.6 EFX05048.1 - 0.01 15.9 0.5 0.078 13.0 0.5 2.6 1 1 0 1 1 1 0 CpXC protein zf-C2H2 PF00096.26 EFX05048.1 - 0.6 10.7 5.0 0.17 12.4 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Spc7 PF08317.11 EFX05048.1 - 1.2 8.0 13.9 1.7 7.5 7.1 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein zf-C2H2_4 PF13894.6 EFX05048.1 - 2.3 9.3 4.6 1.1 10.2 0.8 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger VWA PF00092.28 EFX05049.1 - 0.17 12.1 0.0 5.6 7.2 0.0 2.6 2 1 0 2 2 2 0 von Willebrand factor type A domain MFS_1 PF07690.16 EFX05050.1 - 7.2e-25 87.7 66.1 1.1e-20 73.8 39.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFX05050.1 - 0.0073 15.2 8.5 0.064 12.1 5.6 2.3 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 EFX05050.1 - 0.48 9.2 18.2 0.0085 15.0 8.5 2.4 2 2 0 2 2 2 0 Sugar (and other) transporter Abhydrolase_6 PF12697.7 EFX05053.1 - 3.8e-09 37.5 0.7 3.8e-09 37.5 0.7 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX05053.1 - 1.5e-06 27.7 0.1 2.1e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFX05053.1 - 5.6e-06 26.2 0.1 1.1e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFX05053.1 - 8.7e-05 22.1 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 EFX05053.1 - 0.00055 18.7 0.1 0.006 15.3 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EFX05053.1 - 0.001 19.0 0.1 0.016 15.1 0.0 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold UPF0227 PF05728.12 EFX05053.1 - 0.2 11.6 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Hist_deacetyl PF00850.19 EFX05054.1 - 1.3e-58 198.9 0.0 1.7e-58 198.6 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Retrotrans_gag PF03732.17 EFX05055.1 - 6.4e-08 32.8 0.1 1.1e-07 32.0 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein MMM1 PF10296.9 EFX05056.1 - 0.00043 19.4 0.0 0.075 12.1 0.0 2.1 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 EFX05056.1 - 0.21 12.0 0.0 0.48 10.9 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DLIC PF05783.11 EFX05056.1 - 0.89 8.3 1.7 1.3 7.8 1.7 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) MFS_1 PF07690.16 EFX05057.1 - 5.3e-21 74.9 61.7 3.4e-18 65.7 40.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YccF PF03733.13 EFX05058.1 - 0.03 15.0 1.3 0.03 15.0 1.3 4.4 4 1 0 4 4 4 0 Inner membrane component domain LSM PF01423.22 EFX05059.1 - 6.1e-18 64.3 0.0 7.6e-18 64.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFX05059.1 - 0.023 14.8 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Fungal_trans PF04082.18 EFX05060.1 - 7.7e-12 44.8 0.4 1.3e-11 44.1 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EFX05061.1 - 2.7e-67 227.0 1.7 2.8e-67 227.0 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EFX05061.1 - 4.8e-59 199.3 0.0 1.3e-58 197.9 0.0 1.8 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EFX05061.1 - 4e-50 170.8 1.7 1.2e-49 169.2 1.7 1.8 1 1 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EFX05061.1 - 6.9e-41 140.8 0.3 1.4e-40 139.8 0.3 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EFX05061.1 - 2.1e-35 121.3 0.1 5.4e-35 120.0 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EFX05061.1 - 1.1e-17 64.5 0.0 2.6e-16 60.1 0.0 2.7 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EFX05061.1 - 7.8e-16 59.3 0.0 5.8e-15 56.5 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFX05061.1 - 3.2e-11 43.3 0.0 1.5e-10 41.1 0.0 2.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFX05061.1 - 2.2e-09 37.1 0.0 7.8e-09 35.3 0.0 1.9 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_12 PF08242.12 EFX05061.1 - 2e-05 25.2 0.0 9.4e-05 23.1 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX05061.1 - 0.00024 21.0 0.0 0.0006 19.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EFX05061.1 - 0.00037 20.3 0.0 0.00081 19.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Sacchrp_dh_NADP PF03435.18 EFX05061.1 - 0.0005 20.3 0.4 0.091 13.0 0.0 3.3 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Methyltransf_31 PF13847.6 EFX05061.1 - 0.00072 19.4 0.0 0.0023 17.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain SAT PF16073.5 EFX05061.1 - 0.0022 17.8 2.1 0.0088 15.8 0.2 2.5 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_25 PF13649.6 EFX05061.1 - 0.0025 18.5 0.0 0.012 16.3 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EFX05061.1 - 0.0029 17.2 0.0 0.0089 15.6 0.0 1.8 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_11 PF08241.12 EFX05061.1 - 0.0068 17.0 0.0 0.033 14.8 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EFX05061.1 - 0.0069 16.7 1.0 0.027 14.8 0.3 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site TM1506 PF08973.10 EFX05061.1 - 0.14 11.9 0.3 0.32 10.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) RAC_head PF16717.5 EFX05062.1 - 1.6e-30 106.0 0.3 1.6e-30 106.0 0.3 3.6 3 1 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 EFX05062.1 - 1e-18 67.2 1.5 3.3e-18 65.6 1.5 2.0 1 0 0 1 1 1 1 DnaJ domain V_ATPase_I PF01496.19 EFX05062.1 - 0.34 8.8 5.7 0.5 8.2 5.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family S4 PF01479.25 EFX05063.1 - 2.3e-13 49.6 1.5 2.3e-13 49.6 1.5 2.5 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 EFX05063.1 - 1.3e-05 26.0 0.0 2e-05 25.4 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Uds1 PF15456.6 EFX05063.1 - 0.017 15.3 0.4 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 Up-regulated During Septation PAP2_3 PF14378.6 EFX05065.1 - 2.5e-25 89.3 14.9 3.8e-20 72.4 3.7 2.4 3 0 0 3 3 3 2 PAP2 superfamily PAP2_C PF14360.6 EFX05065.1 - 0.035 14.6 0.0 0.035 14.6 0.0 3.1 3 0 0 3 3 3 0 PAP2 superfamily C-terminal DUF485 PF04341.12 EFX05065.1 - 5.5 7.0 8.4 9.3 6.3 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function, DUF485 PalH PF08733.10 EFX05065.1 - 6.5 5.7 7.3 9.8 5.1 1.2 2.1 2 0 0 2 2 2 0 PalH/RIM21 MFS_1 PF07690.16 EFX05067.1 - 2.6e-35 122.0 13.1 2.6e-35 122.0 13.1 1.8 1 1 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFX05067.1 - 0.0012 18.2 0.7 0.0012 18.2 0.7 2.1 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB Peptidase_S8 PF00082.22 EFX05069.1 - 2.4e-46 158.4 0.0 1.1e-45 156.2 0.0 2.0 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EFX05069.1 - 1.3e-09 38.8 0.0 3.4e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Fn3-like domain F-box-like PF12937.7 EFX05071.1 - 0.0016 18.3 1.2 0.0037 17.1 1.2 1.6 1 0 0 1 1 1 1 F-box-like p25-alpha PF05517.12 EFX05071.1 - 0.0078 16.4 0.2 0.012 15.8 0.2 1.2 1 0 0 1 1 1 1 p25-alpha F-box PF00646.33 EFX05071.1 - 0.054 13.4 0.6 0.1 12.5 0.6 1.4 1 0 0 1 1 1 0 F-box domain DUF1604 PF07713.13 EFX05071.1 - 0.55 10.1 4.0 0.24 11.3 1.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1604) TFIIA PF03153.13 EFX05072.1 - 0.29 11.1 11.8 0.31 11.0 11.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_L21e PF01157.18 EFX05073.1 - 2.8e-46 155.5 4.8 4.5e-46 154.9 4.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e DUF5486 PF17588.2 EFX05073.1 - 0.26 11.2 2.1 5.1 7.1 0.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5486) Methyltransf_25 PF13649.6 EFX05074.1 - 1.1e-16 61.2 0.0 1.9e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05074.1 - 7.2e-15 55.1 0.0 9.5e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05074.1 - 1.4e-12 48.1 0.0 2.6e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX05074.1 - 1.7e-11 44.2 0.0 2.4e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05074.1 - 2.8e-09 37.6 0.0 4.7e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX05074.1 - 0.00019 20.8 0.0 0.00025 20.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EFX05074.1 - 0.0006 18.8 0.0 0.00087 18.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 EFX05074.1 - 0.0044 16.4 0.0 0.0058 16.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 EFX05074.1 - 0.016 14.9 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) CMAS PF02353.20 EFX05074.1 - 0.017 14.4 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pox_MCEL PF03291.16 EFX05074.1 - 0.017 14.3 0.0 0.03 13.4 0.0 1.3 1 1 0 1 1 1 0 mRNA capping enzyme MTS PF05175.14 EFX05074.1 - 0.018 14.6 0.0 0.035 13.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EFX05074.1 - 0.028 14.5 0.0 0.078 13.1 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 EFX05074.1 - 0.073 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EFX05074.1 - 0.21 11.3 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Metallophos PF00149.28 EFX05075.1 - 0.0031 18.0 0.0 0.0041 17.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Bot1p PF12298.8 EFX05076.1 - 1.4e-43 149.1 2.1 2.1e-43 148.4 0.1 1.9 1 1 1 2 2 2 1 Eukaryotic mitochondrial regulator protein PHO4 PF01384.20 EFX05077.1 - 8.8e-100 334.0 22.5 1.1e-99 333.7 22.5 1.1 1 0 0 1 1 1 1 Phosphate transporter family ANAPC5 PF12862.7 EFX05077.1 - 4.5e-12 45.9 0.1 1.2e-11 44.5 0.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 TPR_19 PF14559.6 EFX05077.1 - 0.00092 19.7 2.5 0.49 10.9 0.2 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFX05077.1 - 0.97 9.8 7.0 7.6 6.9 1.1 3.5 2 1 0 2 2 2 0 Tetratricopeptide repeat UPF0444 PF15475.6 EFX05077.1 - 4.4 7.7 6.8 3.2 8.1 0.4 2.6 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 AA_permease_2 PF13520.6 EFX05078.1 - 1.4e-42 146.1 57.6 1.7e-42 145.8 57.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX05078.1 - 3.3e-24 85.3 52.8 1.8e-23 82.9 52.8 1.9 1 1 0 1 1 1 1 Amino acid permease Mcp5_PH PF12814.7 EFX05079.1 - 2.4e-44 150.3 0.1 6.3e-44 149.0 0.1 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EFX05079.1 - 0.00012 22.5 0.0 0.00034 21.1 0.0 1.7 1 0 0 1 1 1 1 PH domain HrpB7 PF09486.10 EFX05079.1 - 0.0054 17.1 4.2 0.0054 17.1 4.2 4.6 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB7) HAP1_N PF04849.13 EFX05079.1 - 0.24 10.5 34.1 3 7.0 1.3 3.8 2 1 0 2 2 2 0 HAP1 N-terminal conserved region Leu_zip PF15294.6 EFX05079.1 - 0.33 10.4 26.4 0.043 13.3 2.0 3.3 2 1 1 3 3 3 0 Leucine zipper XhlA PF10779.9 EFX05079.1 - 2 8.7 9.3 0.16 12.2 2.5 2.7 2 0 0 2 2 2 0 Haemolysin XhlA BLOC1_2 PF10046.9 EFX05079.1 - 4.3 7.7 8.0 4.1 7.8 0.8 3.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lactamase_B PF00753.27 EFX05080.1 - 1.5e-06 28.4 2.0 1.2e-05 25.4 1.7 2.5 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFX05080.1 - 0.0034 16.9 0.2 0.0075 15.8 0.2 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain FBPase PF00316.20 EFX05082.1 - 1.1e-27 96.7 2.3 5.3e-26 91.3 0.0 3.1 3 0 0 3 3 3 2 Fructose-1-6-bisphosphatase, N-terminal domain Epimerase PF01370.21 EFX05083.1 - 4.7e-13 49.2 0.1 1.3e-12 47.7 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX05083.1 - 2.4e-11 43.2 0.0 3.5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFX05083.1 - 2.3e-09 37.4 0.3 4e-09 36.6 0.3 1.6 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFX05083.1 - 6.8e-08 32.3 0.1 1.6e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFX05083.1 - 4.5e-06 26.0 0.0 6.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFX05083.1 - 0.0009 18.5 0.0 0.089 11.9 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EFX05083.1 - 0.0013 18.2 0.0 0.043 13.3 0.0 2.3 2 1 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.13 EFX05083.1 - 0.0047 16.5 0.1 0.0094 15.5 0.1 1.5 1 0 0 1 1 1 1 NmrA-like family MFS_1 PF07690.16 EFX05084.1 - 1.1e-29 103.4 51.9 1.5e-29 103.0 51.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily SPT_ssu-like PF11779.8 EFX05084.1 - 0.53 10.0 4.9 0.67 9.6 1.0 2.9 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like Glyco_hydro_16 PF00722.21 EFX05085.1 - 8e-08 31.9 0.0 2e-07 30.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Spt20 PF12090.8 EFX05085.1 - 0.23 11.1 2.5 0.3 10.7 2.5 1.2 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 EFX05085.1 - 1.1 9.4 9.5 2.4 8.3 9.5 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 ADH_N PF08240.12 EFX05087.1 - 3.7e-18 65.4 4.3 8.3e-18 64.3 4.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX05087.1 - 8.9e-13 48.4 0.0 1.5e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EFX05087.1 - 1.4e-05 24.6 0.0 2.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFX05087.1 - 0.0049 16.2 0.0 0.0087 15.4 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 EFX05087.1 - 0.0072 16.5 0.1 0.023 14.9 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EFX05087.1 - 0.022 14.8 0.0 0.038 14.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EFX05087.1 - 0.027 14.4 0.1 0.045 13.6 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EFX05087.1 - 0.14 13.3 0.0 0.25 12.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 EFX05088.1 - 7.4e-19 68.2 0.3 4e-18 65.8 0.3 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX05088.1 - 3.7e-08 32.9 1.0 1.6e-06 27.6 0.7 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX05088.1 - 9.6e-06 25.4 2.3 0.00041 20.0 1.3 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX05088.1 - 7e-05 23.0 0.9 0.00017 21.8 0.6 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX05088.1 - 0.00026 20.2 0.7 0.00043 19.5 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EFX05088.1 - 0.00053 19.2 0.5 0.0025 17.0 0.5 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFX05088.1 - 0.002 16.9 0.4 0.0035 16.1 0.4 1.3 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EFX05088.1 - 0.0025 17.1 0.1 0.0048 16.2 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 EFX05088.1 - 0.0041 16.0 0.2 0.059 12.2 0.2 2.1 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 EFX05088.1 - 0.008 15.6 0.6 0.013 14.9 0.6 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFX05088.1 - 0.023 14.0 0.0 0.053 12.8 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX05088.1 - 0.043 14.4 0.6 0.089 13.4 0.6 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX05088.1 - 0.061 13.3 0.6 10 6.1 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EFX05088.1 - 0.077 12.0 2.8 0.95 8.4 2.8 2.1 1 1 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EFX05088.1 - 0.18 11.6 0.4 0.4 10.5 0.4 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AA_permease_2 PF13520.6 EFX05089.1 - 2.3e-87 293.6 35.9 2.9e-87 293.2 35.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX05089.1 - 2.1e-18 66.2 33.2 2.7e-18 65.8 33.2 1.1 1 0 0 1 1 1 1 Amino acid permease PsbN PF02468.15 EFX05089.1 - 7.6 6.5 8.4 0.59 10.0 2.2 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) IMS PF00817.20 EFX05090.1 - 8.2e-35 120.0 0.0 1.3e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 EFX05090.1 - 2e-15 56.1 11.2 9.2e-09 34.8 2.0 2.7 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 EFX05090.1 - 9.5e-08 32.8 0.0 3.7e-07 30.9 0.0 2.0 2 1 0 2 2 2 1 impB/mucB/samB family C-terminal domain zf-C2H2 PF00096.26 EFX05090.1 - 0.0062 16.9 7.3 0.63 10.6 0.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX05090.1 - 0.046 14.6 6.9 2.7 9.1 0.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger IMS_HHH PF11798.8 EFX05090.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif OrfB_Zn_ribbon PF07282.11 EFX05090.1 - 1.1 9.3 3.9 4.4 7.3 0.6 2.6 2 0 0 2 2 2 0 Putative transposase DNA-binding domain OPT PF03169.15 EFX05091.1 - 9.9e-152 506.7 37.3 5.7e-151 504.2 37.3 1.8 1 1 0 1 1 1 1 OPT oligopeptide transporter protein DIOX_N PF14226.6 EFX05092.1 - 2.9e-19 70.0 0.0 4.7e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX05092.1 - 7.1e-18 65.0 0.0 1.6e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RE_LlaMI PF09562.10 EFX05092.1 - 0.089 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 LlaMI restriction endonuclease DHHC PF01529.20 EFX05093.1 - 5.3e-20 71.9 2.6 5.3e-20 71.9 2.6 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase zf-CRD PF17979.1 EFX05093.1 - 0.034 14.3 0.1 0.053 13.6 0.1 1.2 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions PHO4 PF01384.20 EFX05093.1 - 0.1 11.6 0.0 4.9 6.1 0.0 2.1 1 1 1 2 2 2 0 Phosphate transporter family FMO-like PF00743.19 EFX05094.1 - 1.6e-15 56.5 0.0 1.8e-12 46.4 0.0 2.4 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EFX05094.1 - 6.7e-14 51.8 0.0 4.1e-12 45.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX05094.1 - 6.6e-07 28.8 0.0 3.5e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFX05094.1 - 7.4e-07 28.7 0.0 2e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX05094.1 - 1.1e-06 28.8 0.0 1.6e-05 25.0 0.0 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFX05094.1 - 0.0049 17.4 0.4 5.6 7.6 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX05094.1 - 0.013 15.4 2.8 3.6 7.6 0.1 4.0 4 0 0 4 4 4 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EFX05094.1 - 0.024 13.7 0.1 0.042 12.9 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EFX05094.1 - 0.027 13.7 0.1 0.062 12.5 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Rbx_binding PF18113.1 EFX05094.1 - 0.076 12.8 0.1 3.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Rubredoxin binding C-terminal domain Shikimate_DH PF01488.20 EFX05094.1 - 0.096 12.8 0.0 25 4.9 0.0 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.12 EFX05094.1 - 0.096 11.7 0.1 0.51 9.3 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 EFX05094.1 - 0.11 12.0 1.0 1.3 8.5 0.1 2.8 2 1 1 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EFX05094.1 - 0.7 8.5 1.9 1.2 7.8 0.6 1.9 2 0 0 2 2 2 0 HI0933-like protein Pkinase PF00069.25 EFX05098.1 - 0.0057 16.1 0.0 0.0093 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PAM2 PF07145.15 EFX05098.1 - 0.44 10.4 5.6 11 5.9 0.1 3.7 4 0 0 4 4 4 0 Ataxin-2 C-terminal region TFIIA PF03153.13 EFX05098.1 - 1.4 8.9 8.7 2.3 8.1 8.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MSA-2c PF12238.8 EFX05098.1 - 1.9 8.5 8.3 3.7 7.5 8.3 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c Sec2p PF06428.11 EFX05099.1 - 5.8e-24 83.9 14.4 5.8e-24 83.9 14.4 3.6 3 0 0 3 3 3 1 GDP/GTP exchange factor Sec2p Beta-lactamase PF00144.24 EFX05100.1 - 2.5e-45 155.2 1.7 5.2e-45 154.1 1.7 1.4 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EFX05100.1 - 0.023 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase CFEM PF05730.11 EFX05101.1 - 1.1e-15 57.5 30.2 2.1e-08 34.2 8.8 2.7 1 1 2 3 3 3 2 CFEM domain hEGF PF12661.7 EFX05101.1 - 8.5 7.2 10.5 22 5.8 1.6 3.4 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFX05101.1 - 8.9 6.7 11.5 24 5.3 1.9 3.1 2 0 0 2 2 2 0 EGF-like domain p450 PF00067.22 EFX05103.1 - 3.4e-59 200.8 0.0 6.5e-59 199.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EFX05104.1 - 5.7e-18 65.3 1.9 1.6e-16 60.5 1.9 2.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX05104.1 - 1.5e-07 31.3 0.2 1.3e-05 24.9 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX05104.1 - 0.00025 20.4 0.3 0.041 13.1 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EFX05104.1 - 0.022 13.8 0.0 1.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Squalene epoxidase NAD_binding_8 PF13450.6 EFX05104.1 - 0.051 13.8 0.4 0.11 12.7 0.4 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 EFX05104.1 - 0.21 11.4 0.1 0.33 10.8 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFX05104.1 - 0.47 11.0 1.4 1.3 9.6 1.4 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX05104.1 - 0.51 9.6 1.8 0.84 8.9 1.8 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase zf-C3HC4_3 PF13920.6 EFX05106.1 - 2.2e-09 37.0 3.6 2.8e-09 36.7 3.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX05106.1 - 6e-09 35.7 6.1 7.9e-09 35.3 6.1 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFX05106.1 - 1.1e-08 34.8 6.7 1.6e-08 34.3 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFX05106.1 - 3.8e-08 33.5 5.4 5.2e-08 33.1 5.4 1.2 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFX05106.1 - 9.1e-07 28.6 4.2 1.6e-06 27.9 4.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFX05106.1 - 9.2e-07 28.8 3.4 4e-06 26.8 1.9 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFX05106.1 - 1.1e-05 25.2 5.1 1.6e-05 24.7 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFX05106.1 - 3.5e-05 23.6 5.4 5.4e-05 23.0 5.4 1.2 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFX05106.1 - 0.00014 21.5 7.1 0.00054 19.7 7.1 1.8 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 EFX05106.1 - 0.0061 16.5 2.5 0.014 15.3 2.6 1.5 1 1 0 1 1 1 1 zinc-ribbons zf-rbx1 PF12678.7 EFX05106.1 - 0.014 15.6 2.9 0.026 14.8 2.9 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EFX05106.1 - 0.021 15.0 6.3 0.32 11.2 7.2 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EFX05106.1 - 0.051 13.7 4.1 0.082 13.0 4.1 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1272 PF06906.11 EFX05106.1 - 0.062 13.4 4.7 0.11 12.6 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-ANAPC11 PF12861.7 EFX05106.1 - 0.067 13.3 1.7 0.11 12.5 1.7 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RgpF PF05045.12 EFX05106.1 - 0.11 11.2 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Rhamnan synthesis protein F zinc_ribbon_11 PF11682.8 EFX05106.1 - 0.19 11.7 2.0 0.27 11.3 2.0 1.2 1 0 0 1 1 1 0 Probable zinc-ribbon zf-P11 PF03854.14 EFX05106.1 - 0.93 9.2 5.8 2.3 7.9 5.8 1.6 1 1 0 1 1 1 0 P-11 zinc finger zf-C3H2C3 PF17122.5 EFX05106.1 - 1.5 8.9 9.5 2.9 8.0 9.5 1.5 1 0 0 1 1 1 0 Zinc-finger FMO-like PF00743.19 EFX05107.1 - 9.4e-15 54.0 0.3 2.1e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EFX05107.1 - 1.4e-11 44.1 0.0 1.1e-06 28.1 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFX05107.1 - 1.6e-11 44.3 0.0 3.2e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX05107.1 - 1.8e-09 37.2 0.0 1.9e-05 24.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX05107.1 - 1.6e-08 34.1 0.1 8.2e-06 25.3 0.0 3.2 1 1 2 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX05107.1 - 8.9e-08 32.3 0.0 1.7e-05 24.9 0.0 3.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EFX05107.1 - 3e-06 27.1 0.0 0.00019 21.1 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FB_lectin PF07367.11 EFX05107.1 - 0.012 15.6 0.5 0.025 14.5 0.5 1.6 1 0 0 1 1 1 0 Fungal fruit body lectin Amino_oxidase PF01593.24 EFX05107.1 - 0.054 12.8 0.0 12 5.1 0.0 2.8 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase LBR_tudor PF09465.10 EFX05107.1 - 0.056 13.3 1.0 0.3 10.9 0.1 2.5 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain Shikimate_DH PF01488.20 EFX05107.1 - 0.15 12.1 0.0 3.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_1 PF00667.20 EFX05108.1 - 2.8e-42 144.8 0.0 4e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFX05108.1 - 1.9e-23 83.3 0.0 2.8e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFX05108.1 - 3.9e-17 62.9 0.0 3.6e-16 59.8 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Fungal_trans PF04082.18 EFX05109.1 - 3.7e-11 42.5 0.6 1e-10 41.1 0.0 1.9 3 0 0 3 3 3 1 Fungal specific transcription factor domain Dynamin_N PF00350.23 EFX05112.1 - 2.1e-39 135.3 0.0 6.3e-39 133.7 0.0 1.8 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 EFX05112.1 - 2.8e-20 72.7 0.0 4.5e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EFX05112.1 - 0.00013 22.0 0.0 0.0012 18.9 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EFX05112.1 - 0.00086 19.4 0.5 0.012 15.7 0.0 3.1 4 0 0 4 4 4 1 Dynamin GTPase effector domain AAA_15 PF13175.6 EFX05112.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain DUF1499 PF07386.11 EFX05112.1 - 0.23 12.0 1.2 0.99 10.0 0.1 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1499) HMG_box PF00505.19 EFX05114.1 - 1.5e-21 76.5 0.1 2.3e-21 76.0 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFX05114.1 - 6.3e-07 29.9 0.0 1.1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain Glyco_hydro_3_C PF01915.22 EFX05115.1 - 2.8e-55 187.5 0.0 8.4e-55 185.9 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX05115.1 - 3.8e-55 187.5 0.0 6.9e-55 186.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX05115.1 - 6.9e-20 70.9 0.4 1.5e-19 69.8 0.4 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EFX05115.1 - 0.00014 21.7 0.0 0.00033 20.5 0.0 1.6 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.11 EFX05115.1 - 0.014 15.7 0.1 0.04 14.2 0.1 1.8 1 0 0 1 1 1 0 CARDB PPC PF04151.15 EFX05115.1 - 0.067 14.3 0.1 0.42 11.8 0.1 2.5 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain RHS_repeat PF05593.14 EFX05115.1 - 0.65 10.6 3.2 0.7 10.5 1.1 2.2 2 0 0 2 2 2 0 RHS Repeat Fungal_trans PF04082.18 EFX05116.1 - 3e-39 134.6 0.0 4.7e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EFX05116.1 - 7.2e-07 29.3 12.7 0.0038 17.6 2.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX05116.1 - 1.8e-05 25.2 10.4 0.012 16.4 1.7 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger Trypan_PARP PF05887.11 EFX05116.1 - 1.2 9.2 5.5 0.28 11.2 1.0 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 EFX05117.1 - 1e-40 139.8 0.3 1.2e-22 80.5 0.3 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05117.1 - 1.8e-13 50.4 0.5 7e-09 35.3 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Methyltransf_23 PF13489.6 EFX05118.1 - 1.1e-19 70.9 0.0 1.5e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05118.1 - 6.2e-14 52.4 0.0 1.2e-13 51.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05118.1 - 1.8e-13 51.0 0.0 7e-13 49.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05118.1 - 1.1e-08 35.7 0.0 1.3e-07 32.3 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05118.1 - 7.3e-08 32.3 0.0 0.0015 18.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EFX05118.1 - 1.7e-06 27.5 0.1 2.7e-05 23.6 0.1 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EFX05118.1 - 0.0015 17.9 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_16 PF10294.9 EFX05118.1 - 0.0095 15.7 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_8 PF05148.15 EFX05118.1 - 0.011 15.6 0.0 0.069 13.0 0.0 2.0 1 1 0 2 2 2 0 Hypothetical methyltransferase FtsJ PF01728.19 EFX05118.1 - 0.036 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 EFX05118.1 - 0.052 12.9 0.0 0.12 11.8 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFX05118.1 - 0.057 13.0 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain GidB PF02527.15 EFX05118.1 - 0.082 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G NAD_binding_8 PF13450.6 EFX05119.1 - 6.9e-09 35.8 0.0 1.6e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFX05119.1 - 7.6e-09 35.4 0.0 2.1e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX05119.1 - 9.2e-07 28.3 0.4 1.6e-06 27.5 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFX05119.1 - 1.4e-06 28.2 0.4 4.2e-06 26.6 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX05119.1 - 3.7e-05 23.1 0.0 0.00019 20.8 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX05119.1 - 0.0003 19.6 0.1 0.00045 19.0 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EFX05119.1 - 0.00032 20.1 0.1 0.00054 19.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFX05119.1 - 0.00075 18.8 0.3 0.0015 17.8 0.3 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFX05119.1 - 0.0011 18.3 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX05119.1 - 0.0012 18.0 0.1 0.0018 17.5 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EFX05119.1 - 0.0094 16.5 0.3 0.029 14.9 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX05119.1 - 0.019 13.9 0.4 0.033 13.1 0.4 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Amino_oxidase PF01593.24 EFX05119.1 - 0.05 12.9 0.0 0.93 8.7 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase IlvN PF07991.12 EFX05119.1 - 0.07 12.7 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Glyco_hydro_18 PF00704.28 EFX05124.1 - 3.7e-55 187.9 2.7 6.3e-55 187.1 2.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EFX05124.1 - 6.3e-26 90.2 1.3 4.4e-05 23.5 0.1 4.9 4 0 0 4 4 4 4 LysM domain Chitin_bind_1 PF00187.19 EFX05124.1 - 0.00042 20.7 9.6 0.00042 20.7 9.6 3.4 3 0 0 3 3 3 1 Chitin recognition protein HTH_23 PF13384.6 EFX05124.1 - 0.12 12.2 0.0 15 5.5 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain F-box PF00646.33 EFX05125.1 - 9.2e-05 22.2 0.1 0.00049 19.9 0.1 2.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFX05125.1 - 0.0058 16.5 0.0 0.031 14.2 0.0 2.3 1 0 0 1 1 1 1 F-box-like FAD_binding_4 PF01565.23 EFX05126.1 - 2.2e-14 53.4 3.2 9.1e-14 51.4 3.2 2.0 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFX05126.1 - 0.0051 16.9 0.0 0.022 14.9 0.0 2.0 1 0 0 1 1 1 1 Berberine and berberine like Glyco_hydro_17 PF00332.18 EFX05128.1 - 8.9e-10 38.6 1.5 1.3e-07 31.6 0.3 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 F-box-like PF12937.7 EFX05129.1 - 9.1e-08 31.9 0.6 2.4e-07 30.5 0.6 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFX05129.1 - 3.4e-07 30.0 0.3 7.7e-07 28.8 0.3 1.6 1 0 0 1 1 1 1 F-box domain DSHCT PF08148.12 EFX05130.1 - 2.1e-43 147.8 0.6 3.9e-43 146.9 0.6 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EFX05130.1 - 3.9e-18 65.8 0.0 7.8e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 EFX05130.1 - 2e-16 60.7 0.0 4.1e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain Ski2_N PF17911.1 EFX05130.1 - 4.8e-12 45.8 0.0 3.1e-06 27.0 0.0 2.5 2 0 0 2 2 2 2 Ski2 N-terminal region Helicase_C PF00271.31 EFX05130.1 - 9e-07 29.2 0.0 2.1e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX05130.1 - 2.4e-06 27.6 0.0 4.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Cwf_Cwc_15 PF04889.12 EFX05130.1 - 0.01 15.6 14.8 0.022 14.5 14.8 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 EFX05130.1 - 0.072 12.4 12.9 0.11 11.8 12.9 1.2 1 0 0 1 1 1 0 BUD22 RNA_pol_3_Rpc31 PF11705.8 EFX05130.1 - 0.11 12.8 17.7 0.25 11.6 17.7 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.13 EFX05130.1 - 0.65 9.9 11.5 1.1 9.2 11.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 EFX05130.1 - 2.8 6.0 14.3 4.7 5.3 14.3 1.2 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 EFX05130.1 - 3.4 6.1 16.1 5.3 5.5 16.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Methyltransf_23 PF13489.6 EFX05131.1 - 0.0015 18.3 0.0 0.019 14.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain GTP_cyclohydroI PF01227.22 EFX05132.1 - 1.6e-73 246.0 0.1 2e-73 245.6 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EFX05132.1 - 0.0072 16.5 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein Transp_cyt_pur PF02133.15 EFX05133.1 - 6e-27 94.5 30.9 8.5e-27 94.0 30.9 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CN_hydrolase PF00795.22 EFX05134.1 - 1.1e-38 133.1 0.0 1.4e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zinc_ribbon_10 PF10058.9 EFX05136.1 - 1.5e-17 63.0 0.1 2.3e-17 62.4 0.1 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Swi3 PF07962.12 EFX05138.1 - 1.7e-29 101.6 0.3 2.5e-29 101.1 0.3 1.2 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Asp_Glu_race PF01177.22 EFX05141.1 - 8.3e-08 32.3 0.1 1.3e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase AroM PF07302.11 EFX05141.1 - 0.16 11.4 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 AroM protein Glyco_hydro_18 PF00704.28 EFX05142.1 - 2.3e-72 244.4 0.2 2.8e-72 244.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EFX05142.1 - 9e-07 29.3 21.7 2.2e-06 28.0 21.5 1.7 1 1 0 1 1 1 1 Chitin recognition protein MFS_1 PF07690.16 EFX05143.1 - 5.7e-46 157.1 48.6 9.2e-46 156.4 48.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Snf7 PF03357.21 EFX05144.1 - 0.00092 18.8 23.6 0.00092 18.8 23.6 1.5 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 EFX05144.1 - 0.042 13.8 8.3 0.072 13.0 8.3 1.5 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DltD PF04914.12 EFX05144.1 - 0.28 10.5 12.2 0.4 10.0 12.2 1.1 1 0 0 1 1 1 0 DltD protein Vfa1 PF08432.10 EFX05144.1 - 1.3 9.3 9.7 2.5 8.4 9.7 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CEL_III_C PF18054.1 EFX05144.1 - 1.9 8.6 5.9 3 7.9 5.9 1.4 1 0 0 1 1 1 0 CEL-III C-terminal p450 PF00067.22 EFX05145.1 - 1.6e-61 208.5 0.0 2.1e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NADH-u_ox-rdase PF10785.9 EFX05146.1 - 5.5e-29 100.7 0.1 1.1e-28 99.7 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 EFX05146.1 - 8.2e-24 83.4 0.0 1.3e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Fumerase_C PF05683.12 EFX05146.1 - 0.054 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Fumarase C-terminus Asparaginase PF00710.20 EFX05147.1 - 1.4e-49 168.3 0.4 2.2e-49 167.6 0.4 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFX05147.1 - 2.7e-15 56.6 0.0 2.2e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain Glucosamine_iso PF01182.20 EFX05148.1 - 2.1e-22 80.2 0.0 3.1e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.13 EFX05148.1 - 0.031 13.4 0.1 0.059 12.5 0.1 1.4 1 0 0 1 1 1 0 Putative sugar-binding domain FA_synthesis PF02504.15 EFX05148.1 - 0.26 10.3 3.5 1.1 8.3 0.6 2.1 1 1 1 2 2 2 0 Fatty acid synthesis protein Glyco_hydro_15 PF00723.21 EFX05149.1 - 2.5e-100 336.4 2.0 3e-100 336.1 2.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EFX05149.1 - 1.2e-33 114.9 0.1 3.2e-33 113.5 0.1 1.8 1 0 0 1 1 1 1 Starch binding domain DUF3498 PF12004.8 EFX05149.1 - 2.2 7.4 6.4 3.3 6.8 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) MFS_1 PF07690.16 EFX05151.1 - 2.4e-27 95.8 35.2 8.9e-16 57.7 8.8 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily TRI12 PF06609.13 EFX05151.1 - 0.00061 18.3 1.7 0.0073 14.8 1.6 2.0 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFX05151.1 - 0.003 16.5 18.9 73 2.0 2.8 2.8 3 1 0 3 3 3 0 Sugar (and other) transporter PufQ PF05398.11 EFX05151.1 - 0.11 12.6 0.4 0.39 10.9 0.4 2.0 1 0 0 1 1 1 0 PufQ cytochrome subunit AA_permease PF00324.21 EFX05152.1 - 2.4e-94 316.7 36.2 2.7e-94 316.5 36.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX05152.1 - 1.4e-15 57.1 40.7 1.8e-15 56.8 40.7 1.0 1 0 0 1 1 1 1 Amino acid permease NmrA PF05368.13 EFX05154.1 - 7.4e-18 64.9 0.0 9.6e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX05154.1 - 1.9e-14 54.0 0.4 6.1e-14 52.3 0.1 1.9 1 1 1 2 2 2 1 NAD(P)H-binding DUF1806 PF08830.10 EFX05154.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1806) GRIP PF01465.20 EFX05155.1 - 1.8e-13 50.2 0.0 4.8e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 GRIP domain GAS PF13851.6 EFX05155.1 - 0.00032 20.1 116.4 0.00086 18.7 18.9 7.2 2 2 3 6 6 6 4 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EFX05155.1 - 0.003 16.5 22.5 0.003 16.5 22.5 6.6 2 2 4 6 6 6 4 Spc7 kinetochore protein DUF4407 PF14362.6 EFX05155.1 - 0.0049 16.3 14.3 0.0049 16.3 14.3 8.1 1 1 8 9 9 9 5 Domain of unknown function (DUF4407) LtuB PF17455.2 EFX05155.1 - 1 10.1 2.5 13 6.5 0.1 3.3 2 0 0 2 2 2 0 Late transcription unit B HLH PF00010.26 EFX05156.1 - 4.9e-16 58.4 0.0 8.2e-16 57.7 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.21 EFX05156.1 - 0.044 13.9 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 bZIP transcription factor Ndc1_Nup PF09531.10 EFX05156.1 - 0.73 8.5 9.9 0.92 8.1 9.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EFX05156.1 - 3 6.3 8.2 3.7 6.0 8.2 1.1 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 EFX05156.1 - 6.3 6.8 6.1 9.8 6.2 6.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Aldo_ket_red PF00248.21 EFX05157.1 - 7.2e-66 222.4 0.0 8.9e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.32 EFX05158.1 - 1.7e-15 57.1 6.9 8.3e-10 39.1 0.1 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05158.1 - 0.00095 19.4 0.0 0.21 11.9 0.0 3.8 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX05158.1 - 0.0079 15.2 0.0 0.055 12.4 0.0 2.0 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein SH3_16 PF18348.1 EFX05158.1 - 0.052 13.3 0.0 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain GMC_oxred_N PF00732.19 EFX05159.1 - 2.4e-46 158.5 0.0 3e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX05159.1 - 1.4e-37 129.4 0.0 2.1e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EFX05159.1 - 2.9e-05 23.3 0.0 5e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFX05159.1 - 0.00056 20.1 0.0 0.0017 18.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX05159.1 - 0.0024 17.5 0.1 0.015 14.9 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX05159.1 - 0.0033 16.7 0.0 0.0053 16.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX05159.1 - 0.008 15.3 0.1 0.41 9.7 0.0 2.5 3 0 0 3 3 3 1 FAD binding domain Trp_halogenase PF04820.14 EFX05159.1 - 0.044 12.6 0.0 0.065 12.1 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EFX05159.1 - 0.19 11.0 0.0 0.31 10.2 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 EFX05159.1 - 0.21 12.2 0.0 1.1 9.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase bZIP_2 PF07716.15 EFX05160.1 - 1.7e-06 28.0 18.3 5e-06 26.5 18.3 1.9 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EFX05160.1 - 6.5e-05 23.0 13.9 0.00014 21.9 13.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EFX05160.1 - 0.11 13.1 10.2 0.24 11.9 10.2 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor SprA-related PF12118.8 EFX05160.1 - 0.16 11.1 8.1 0.14 11.3 1.9 2.2 2 0 0 2 2 2 0 SprA-related family MFS_1 PF07690.16 EFX05161.1 - 4.5e-28 98.2 26.1 4.5e-28 98.2 26.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Carbam_trans_C PF16861.5 EFX05161.1 - 0.19 11.3 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus Fungal_trans PF04082.18 EFX05162.1 - 2.1e-12 46.6 0.0 4e-12 45.7 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05162.1 - 0.00047 20.2 7.0 0.0012 18.9 7.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4202 PF13875.6 EFX05162.1 - 0.12 12.2 0.0 3 7.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4202) Dynamin_N PF00350.23 EFX05163.1 - 2.2e-14 53.9 0.0 6.7e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EFX05163.1 - 6.2e-07 29.5 0.1 2.2e-05 24.5 0.1 2.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFX05163.1 - 1.4e-06 28.3 0.1 2e-05 24.6 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EFX05163.1 - 0.00062 20.2 1.9 0.0033 17.8 0.0 2.9 3 1 0 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 EFX05163.1 - 0.0034 17.9 0.0 0.0094 16.5 0.0 1.8 1 0 0 1 1 1 1 ABC transporter Sec20 PF03908.13 EFX05163.1 - 0.015 15.2 0.9 0.063 13.2 0.2 2.6 2 0 0 2 2 2 0 Sec20 AAA_18 PF13238.6 EFX05163.1 - 0.033 14.7 0.0 0.11 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFX05163.1 - 0.083 13.2 0.0 1.2 9.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain P22_Tail-4 PF11650.8 EFX05163.1 - 0.1 12.5 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 P22 tail accessory factor AAA_29 PF13555.6 EFX05163.1 - 0.14 12.0 0.1 0.33 10.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EFX05163.1 - 0.15 12.3 0.0 1.1 9.4 0.0 2.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Wbp11 PF09429.10 EFX05163.1 - 0.38 11.2 5.0 1.3 9.5 5.0 1.9 1 0 0 1 1 1 0 WW domain binding protein 11 WD40 PF00400.32 EFX05165.1 - 4.2e-14 52.7 0.4 0.32 12.0 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05165.1 - 0.0099 16.2 0.0 32 4.9 0.0 3.7 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SOG2 PF10428.9 EFX05165.1 - 0.52 9.4 6.2 0.9 8.7 6.2 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Alpha-amylase PF00128.24 EFX05166.1 - 1.2e-66 225.6 0.1 1.7e-66 225.1 0.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain CBM_20 PF00686.19 EFX05166.1 - 7.3e-33 112.4 0.3 1.9e-32 111.0 0.3 1.8 1 0 0 1 1 1 1 Starch binding domain DUF1966 PF09260.11 EFX05166.1 - 4.3e-28 97.4 1.1 2e-27 95.3 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1966) Glyco_hydro_76 PF03663.14 EFX05167.1 - 1.3e-37 130.2 17.4 2e-37 129.6 17.4 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFX05167.1 - 4e-05 22.9 1.6 0.006 15.7 0.1 3.2 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EFX05167.1 - 0.00065 18.3 0.2 0.019 13.5 0.1 2.1 1 1 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 GlcNAc_2-epim PF07221.11 EFX05167.1 - 0.06 12.6 0.9 2 7.6 0.1 3.0 3 0 0 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) TauD PF02668.16 EFX05168.1 - 2.9e-37 128.9 0.1 3.6e-37 128.6 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EFX05169.1 - 4.5e-39 134.4 43.9 3.8e-38 131.3 43.6 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05169.1 - 9.1e-14 51.1 8.0 9.1e-14 51.1 8.0 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter DUF5337 PF17272.2 EFX05169.1 - 0.18 11.7 1.3 1.9 8.4 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5337) Zn_clus PF00172.18 EFX05170.1 - 0.00048 20.2 12.4 0.00076 19.6 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EFX05171.1 - 1.7e-21 76.5 18.6 2.1e-21 76.2 18.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MPS-4 PF17523.2 EFX05171.1 - 0.11 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 DUF4231 PF14015.6 EFX05171.1 - 0.88 10.1 2.7 0.65 10.5 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Fungal_trans_2 PF11951.8 EFX05174.1 - 4.1e-28 98.3 0.4 1.8e-27 96.2 0.4 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain F-box_4 PF15966.5 EFX05175.1 - 0.00046 20.0 3.4 0.00051 19.9 0.1 2.5 3 0 0 3 3 3 1 F-box F-box PF00646.33 EFX05175.1 - 0.00084 19.2 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 F-box domain Baculo_LEF5_C PF11792.8 EFX05175.1 - 0.056 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain AnkUBD PF18418.1 EFX05175.1 - 0.16 12.1 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain Zn_clus PF00172.18 EFX05176.1 - 1.4e-06 28.3 9.5 2.3e-06 27.6 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexokinase_2 PF03727.16 EFX05177.1 - 5.5e-60 202.8 0.1 8.5e-45 153.1 0.0 2.1 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 EFX05177.1 - 1.4e-58 198.1 0.0 2e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase adh_short_C2 PF13561.6 EFX05178.1 - 1.1e-47 162.6 0.2 1.2e-47 162.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX05178.1 - 4.3e-39 134.0 0.2 5.3e-39 133.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX05178.1 - 8.3e-11 42.1 0.1 1.7e-10 41.1 0.1 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EFX05178.1 - 0.00027 20.5 0.1 0.00042 19.9 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ThiF PF00899.21 EFX05178.1 - 0.011 15.1 2.0 0.023 14.1 0.1 1.9 1 1 1 2 2 2 0 ThiF family GDP_Man_Dehyd PF16363.5 EFX05178.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Dak1_2 PF13684.6 EFX05178.1 - 0.057 12.5 0.1 0.096 11.7 0.1 1.4 1 0 0 1 1 1 0 Dihydroxyacetone kinase family ETF PF01012.21 EFX05178.1 - 0.12 12.2 2.7 0.067 13.1 0.7 1.7 2 0 0 2 2 2 0 Electron transfer flavoprotein domain RuvX PF03652.15 EFX05178.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction resolvase Pex16 PF08610.10 EFX05179.1 - 1.5e-127 425.2 0.0 2.5e-127 424.5 0.0 1.3 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Totivirus_coat PF05518.11 EFX05179.1 - 0.091 10.8 3.9 0.12 10.4 3.9 1.1 1 0 0 1 1 1 0 Totivirus coat protein Aldedh PF00171.22 EFX05180.1 - 5.3e-148 493.3 0.0 6.3e-148 493.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NCD1 PF04904.13 EFX05180.1 - 0.18 11.9 0.0 0.46 10.5 0.0 1.7 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) Fungal_trans_2 PF11951.8 EFX05181.1 - 6.1e-05 22.0 0.8 7.4e-05 21.7 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.26 EFX05182.1 - 2.6e-24 85.6 0.7 8.6e-24 84.0 0.2 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX05182.1 - 2.7e-17 64.1 0.1 6.2e-17 62.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX05182.1 - 1.3e-08 34.6 0.1 4.1e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain SRR1 PF07985.12 EFX05183.1 - 5.6e-10 39.1 0.0 1.1e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 SRR1 DUF5129 PF17173.4 EFX05183.1 - 0.08 12.1 0.6 0.11 11.5 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) NMT1 PF09084.11 EFX05184.1 - 1.6e-75 253.8 0.0 2.1e-75 253.4 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 EFX05184.1 - 4.5e-08 33.1 0.0 0.082 12.6 0.0 3.7 3 1 1 4 4 4 2 NMT1-like family Dak1 PF02733.17 EFX05184.1 - 0.15 10.9 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Dak1 domain FMN_red PF03358.15 EFX05184.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 NADPH-dependent FMN reductase Sugar_tr PF00083.24 EFX05185.1 - 5.2e-128 427.7 28.4 6e-128 427.5 28.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05185.1 - 6.4e-20 71.4 47.4 6.6e-15 54.9 20.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4293 PF14126.6 EFX05185.1 - 1.6 8.9 4.4 0.43 10.8 0.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) AA_permease_2 PF13520.6 EFX05186.1 - 1.6e-57 195.3 49.7 1.9e-57 195.0 49.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX05186.1 - 8.1e-21 74.2 43.3 1.1e-20 73.8 43.3 1.1 1 0 0 1 1 1 1 Amino acid permease PUL PF08324.11 EFX05187.1 - 1.5e-57 195.0 1.7 2e-57 194.5 1.7 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 EFX05187.1 - 2.2e-22 78.9 15.7 3.7e-07 30.7 1.0 7.4 8 0 0 8 8 8 3 WD domain, G-beta repeat PFU PF09070.11 EFX05187.1 - 8.8e-07 29.2 0.2 1.5e-06 28.4 0.2 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) FlgD_ig PF13860.6 EFX05187.1 - 0.034 14.0 0.7 3.3 7.6 0.1 3.1 3 0 0 3 3 3 0 FlgD Ig-like domain PQQ_3 PF13570.6 EFX05187.1 - 1 10.0 4.1 3.3 8.3 0.3 3.8 2 1 1 3 3 3 0 PQQ-like domain NmrA PF05368.13 EFX05188.1 - 4e-23 82.2 0.0 4.9e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFX05188.1 - 4.8e-21 75.5 0.0 1.1e-20 74.4 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_11 PF14833.6 EFX05188.1 - 0.082 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase SWIRM PF04433.17 EFX05189.1 - 6.7e-13 48.8 0.1 1.5e-11 44.4 0.0 2.4 2 0 0 2 2 2 1 SWIRM domain TFIIA PF03153.13 EFX05189.1 - 1.3 9.0 17.0 1.8 8.5 17.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OPT PF03169.15 EFX05190.1 - 1.7e-175 585.2 55.4 2e-175 585.0 55.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.6 EFX05190.1 - 0.032 13.6 0.9 0.12 11.7 0.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) E1-E2_ATPase PF00122.20 EFX05190.1 - 0.14 11.7 0.4 0.65 9.5 0.4 2.2 1 0 0 1 1 1 0 E1-E2 ATPase Glyco_hydro_2_N PF02837.18 EFX05191.1 - 9.6e-43 146.0 0.0 1e-42 145.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_16 PF00722.21 EFX05192.1 - 5.2e-44 149.8 3.3 1e-43 148.9 3.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Myb_DNA-binding PF00249.31 EFX05193.1 - 0.00064 19.9 0.1 0.07 13.3 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX05193.1 - 0.00092 19.4 0.1 0.075 13.3 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Glyco_transf_15 PF01793.16 EFX05194.1 - 2.7e-94 316.1 5.9 1.1e-93 314.0 5.9 1.7 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Myb_DNA-binding PF00249.31 EFX05195.1 - 1.5e-09 37.9 0.2 2.5e-09 37.2 0.2 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX05195.1 - 0.00017 21.8 0.0 0.00048 20.3 0.0 1.8 1 1 0 1 1 1 1 Myb-like DNA-binding domain cwf18 PF08315.12 EFX05195.1 - 0.017 15.8 3.6 0.031 14.9 3.6 1.3 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor ARS2 PF04959.13 EFX05195.1 - 1.1 9.5 11.8 2.2 8.6 11.8 1.6 1 0 0 1 1 1 0 Arsenite-resistance protein 2 Lin-8 PF03353.15 EFX05195.1 - 8.7 5.8 8.3 13 5.3 8.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Chs7 PF12271.8 EFX05196.1 - 1.7e-120 401.7 14.4 2e-120 401.5 14.4 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3382 PF11862.8 EFX05196.1 - 0.024 14.9 3.9 0.025 14.9 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3382) Cas_Csy4 PF09618.10 EFX05198.1 - 1.9 8.6 6.8 0.62 10.2 0.6 2.7 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Csy4) Phage_holin_3_7 PF05449.11 EFX05199.1 - 0.19 11.8 3.5 0.5 10.4 3.5 1.7 1 0 0 1 1 1 0 Putative 3TM holin, Phage_holin_3 COPIIcoated_ERV PF07970.12 EFX05200.1 - 2.2e-87 292.6 0.0 3.7e-87 291.8 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFX05200.1 - 1.5e-29 102.1 0.0 4.3e-29 100.7 0.0 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Acetyltransf_7 PF13508.7 EFX05202.1 - 9.9e-07 29.1 0.0 1.6e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX05202.1 - 1.4e-06 28.5 0.0 2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX05202.1 - 0.00023 21.1 0.0 0.00046 20.1 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX05202.1 - 0.034 14.1 0.0 0.097 12.6 0.0 1.8 1 1 0 1 1 1 0 FR47-like protein NDT80_PhoG PF05224.12 EFX05204.1 - 1e-45 156.2 0.3 1.5e-43 149.2 0.0 2.1 2 0 0 2 2 2 2 NDT80 / PhoG like DNA-binding family Kinesin PF00225.23 EFX05205.1 - 7.7e-82 274.9 0.0 1.1e-81 274.4 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFX05205.1 - 1.7e-20 73.5 0.0 3e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding DUF1690 PF07956.11 EFX05205.1 - 8.1e-05 23.1 4.0 8.1e-05 23.1 4.0 2.2 2 0 0 2 2 2 1 Protein of Unknown function (DUF1690) DUF3701 PF12482.8 EFX05205.1 - 0.0089 16.1 0.1 0.044 13.9 0.0 2.1 2 0 0 2 2 2 1 Phage integrase protein HHH_5 PF14520.6 EFX05205.1 - 0.021 15.4 1.9 1.6 9.4 0.0 3.1 3 0 0 3 3 3 0 Helix-hairpin-helix domain HHH_3 PF12836.7 EFX05205.1 - 0.038 14.2 0.0 5.3 7.4 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif HHH PF00633.23 EFX05205.1 - 0.077 12.9 0.1 7.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif Neuropep_like PF15161.6 EFX05205.1 - 0.12 12.0 0.4 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Neuropeptide-like HAUS6_N PF14661.6 EFX05205.1 - 2.2 7.8 5.7 6.3 6.3 5.7 1.8 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Malic_M PF03949.15 EFX05206.1 - 9.2e-91 303.7 0.0 1.8e-90 302.7 0.0 1.5 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFX05206.1 - 6.4e-69 231.4 0.0 1.1e-68 230.6 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Cerato-platanin PF07249.12 EFX05207.1 - 0.00036 20.6 0.5 0.0011 19.1 0.1 2.2 2 0 0 2 2 2 1 Cerato-platanin RNA_pol_Rpb2_6 PF00562.28 EFX05208.1 - 7.9e-115 384.0 0.1 1.1e-114 383.6 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFX05208.1 - 1.7e-31 109.4 0.0 2.7e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EFX05208.1 - 1.8e-28 98.5 0.0 4.6e-28 97.2 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 EFX05208.1 - 9.5e-26 89.6 0.0 2e-25 88.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EFX05208.1 - 1.4e-23 83.6 0.0 2.3e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EFX05208.1 - 1.5e-15 57.4 0.0 1.1e-13 51.3 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 zinc_ribbon_15 PF17032.5 EFX05208.1 - 0.068 13.9 0.1 0.16 12.8 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon family zf-HIT PF04438.16 EFX05209.1 - 1.4e-09 37.6 4.4 2.2e-09 37.0 4.4 1.3 1 0 0 1 1 1 1 HIT zinc finger zinc_ribbon_2 PF13240.6 EFX05209.1 - 0.74 9.6 5.6 3.1 7.6 0.8 2.4 2 0 0 2 2 2 0 zinc-ribbon domain ARHGEF5_35 PF15441.6 EFX05209.1 - 0.82 8.6 6.4 1.2 8.1 6.4 1.2 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 zf-B_box PF00643.24 EFX05209.1 - 1.4 9.1 6.6 4 7.7 6.7 1.6 1 1 0 1 1 1 0 B-box zinc finger DHC_N1 PF08385.12 EFX05210.1 - 1.3e-123 413.6 0.3 1.3e-123 413.6 0.3 3.7 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EFX05210.1 - 1.7e-121 405.2 0.0 1.2e-120 402.5 0.0 2.4 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFX05210.1 - 2.6e-116 389.0 2.9 2.6e-116 389.0 2.9 5.3 4 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EFX05210.1 - 7.8e-74 247.5 0.0 2.7e-73 245.7 0.0 2.1 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_8 PF12780.7 EFX05210.1 - 9.9e-65 218.4 0.0 3.7e-63 213.3 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.7 EFX05210.1 - 5.7e-41 140.7 3.4 5.7e-41 140.7 3.4 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFX05210.1 - 7.1e-41 139.7 0.0 2.6e-35 121.6 0.0 4.7 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_5 PF07728.14 EFX05210.1 - 5.2e-31 107.5 0.0 2.4e-11 43.8 0.0 6.0 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EFX05210.1 - 3.9e-28 97.9 0.0 7.6e-26 90.6 0.0 3.3 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EFX05210.1 - 2.7e-24 85.8 0.0 6.2e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain PAP2 PF01569.21 EFX05210.1 - 2.8e-18 66.0 0.5 5.3e-18 65.1 0.5 1.4 1 0 0 1 1 1 1 PAP2 superfamily Dynein_AAA_lid PF17852.1 EFX05210.1 - 5.2e-15 55.7 0.0 1.9e-14 53.9 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EFX05210.1 - 4.5e-14 52.9 5.2 0.012 15.9 0.0 6.6 7 1 0 7 7 4 3 AAA domain AAA PF00004.29 EFX05210.1 - 8.5e-14 52.1 0.0 0.0022 18.4 0.0 4.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFX05210.1 - 3.7e-11 43.4 5.9 0.0044 17.2 0.0 6.7 6 0 0 6 6 5 3 AAA domain AAA_18 PF13238.6 EFX05210.1 - 9.7e-11 42.3 0.2 0.11 13.1 0.0 5.1 4 0 0 4 4 4 3 AAA domain T2SSE PF00437.20 EFX05210.1 - 5.3e-07 29.0 0.0 0.021 13.9 0.0 3.7 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_16 PF13191.6 EFX05210.1 - 2e-06 28.3 17.6 1.4 9.3 0.0 8.9 9 0 0 9 9 6 2 AAA ATPase domain Mg_chelatase PF01078.21 EFX05210.1 - 1.2e-05 24.9 0.5 0.73 9.2 0.0 4.2 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EFX05210.1 - 1.6e-05 24.7 1.8 2.9 7.5 0.0 5.6 5 1 0 5 5 4 1 AAA domain AAA_19 PF13245.6 EFX05210.1 - 3.8e-05 24.0 0.8 0.3 11.4 0.0 4.9 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.6 EFX05210.1 - 5.4e-05 22.9 0.0 2.5 7.9 0.0 3.6 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_25 PF13481.6 EFX05210.1 - 8.8e-05 22.2 0.1 0.065 12.8 0.0 3.7 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.27 EFX05210.1 - 0.00013 22.4 0.0 5.3 7.6 0.0 4.2 3 0 0 3 3 3 0 ABC transporter FtsK_SpoIIIE PF01580.18 EFX05210.1 - 0.0003 20.2 0.0 3.2 7.1 0.0 3.8 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_lid_1 PF17857.1 EFX05210.1 - 0.00044 20.4 0.0 0.0024 18.1 0.0 2.4 2 0 0 2 2 1 1 AAA+ lid domain UbiA PF01040.18 EFX05210.1 - 0.00072 18.9 1.4 0.00072 18.9 1.4 1.8 2 0 0 2 2 2 1 UbiA prenyltransferase family AAA_24 PF13479.6 EFX05210.1 - 0.0019 18.0 2.8 13 5.5 0.0 5.6 6 0 0 6 6 6 0 AAA domain TrwB_AAD_bind PF10412.9 EFX05210.1 - 0.0026 16.7 0.1 0.79 8.6 0.0 3.5 3 0 0 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 EFX05210.1 - 0.0076 15.5 0.0 3.1 7.0 0.0 3.9 4 0 0 4 4 3 1 Zeta toxin BRE1 PF08647.11 EFX05210.1 - 0.01 15.9 0.4 0.01 15.9 0.4 4.1 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase IstB_IS21 PF01695.17 EFX05210.1 - 0.012 15.3 1.0 0.97 9.1 0.0 4.1 4 0 0 4 4 4 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EFX05210.1 - 0.016 15.1 0.1 43 4.0 0.0 4.0 3 0 0 3 3 3 0 NTPase RNA_helicase PF00910.22 EFX05210.1 - 0.021 15.2 0.3 30 5.1 0.0 4.3 4 0 0 4 4 4 0 RNA helicase G-alpha PF00503.20 EFX05210.1 - 0.023 13.9 0.0 5.1 6.2 0.0 4.1 4 1 0 4 4 3 0 G-protein alpha subunit Viral_helicase1 PF01443.18 EFX05210.1 - 0.029 14.1 0.0 8.7 6.0 0.0 3.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 EFX05210.1 - 0.03 14.2 0.1 7.4 6.4 0.0 3.8 4 0 0 4 4 4 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EFX05210.1 - 0.045 13.8 0.1 0.96 9.6 0.0 3.2 3 0 0 3 3 3 0 50S ribosome-binding GTPase HWE_HK PF07536.14 EFX05210.1 - 0.08 13.7 3.1 19 6.0 0.1 5.3 4 0 0 4 4 4 0 HWE histidine kinase NACHT PF05729.12 EFX05210.1 - 0.09 12.7 4.7 34 4.3 0.1 4.7 5 0 0 5 5 3 0 NACHT domain DUF3450 PF11932.8 EFX05210.1 - 0.1 11.9 13.8 0.35 10.2 0.8 3.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Phage_GP20 PF06810.11 EFX05210.1 - 0.13 12.0 8.5 0.79 9.5 4.5 3.2 2 0 0 2 2 2 0 Phage minor structural protein GP20 MbeB_N PF04837.12 EFX05210.1 - 0.36 11.2 2.2 2.7 8.3 0.1 3.0 2 0 0 2 2 2 0 MbeB-like, N-term conserved region AAA_17 PF13207.6 EFX05210.1 - 1.1 9.6 3.4 1.6e+02 2.7 0.0 4.6 4 0 0 4 4 3 0 AAA domain DUF87 PF01935.17 EFX05210.1 - 1.5 8.9 5.5 3.7 7.6 0.0 4.2 4 0 0 4 4 3 0 Helicase HerA, central domain AAA_23 PF13476.6 EFX05210.1 - 5.5 7.4 10.0 62 4.0 0.0 5.7 6 1 0 6 6 5 0 AAA domain GDI PF00996.18 EFX05211.1 - 3.6e-193 642.0 0.0 4e-193 641.8 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EFX05211.1 - 0.098 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Kinetochor_Ybp2 PF08568.10 EFX05212.1 - 1e-98 331.5 0.0 1e-69 235.7 0.0 2.6 2 1 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin DUF4607 PF15380.6 EFX05212.1 - 0.0081 15.7 0.1 0.017 14.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4607) MSC PF09402.10 EFX05212.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain SNF2_N PF00176.23 EFX05213.1 - 4.5e-64 216.4 0.2 1.4e-63 214.7 0.2 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX05213.1 - 1.7e-20 73.4 0.0 5e-20 71.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX05213.1 - 1.7e-06 28.1 0.0 4.4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EFX05213.1 - 0.0046 16.2 0.0 0.11 11.6 0.0 2.9 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 EFX05213.1 - 0.0047 16.2 2.3 0.005 16.1 0.0 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EFX05213.1 - 0.029 14.1 1.4 0.046 13.4 0.0 2.0 3 0 0 3 3 3 0 SWI2/SNF2 ATPase DUF4603 PF15376.6 EFX05213.1 - 4.7 4.5 8.4 6.7 4.0 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Palm_thioest PF02089.15 EFX05214.1 - 7.9e-75 251.8 0.0 9.3e-75 251.6 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 EFX05214.1 - 0.042 13.2 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 EFX05214.1 - 0.089 12.4 0.0 0.15 11.6 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold THOC2_N PF16134.5 EFX05215.1 - 1.8e-243 809.8 0.0 4.2e-243 808.6 0.0 1.6 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EFX05215.1 - 3e-90 302.5 0.0 3e-90 302.5 0.0 1.6 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EFX05215.1 - 3.4e-27 94.3 0.1 8.5e-27 93.0 0.1 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Spt20 PF12090.8 EFX05215.1 - 0.11 12.1 9.3 0.3 10.6 9.3 1.8 1 0 0 1 1 1 0 Spt20 family Lactonase PF10282.9 EFX05216.1 - 0.087 12.1 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Complex1_LYR PF05347.15 EFX05217.1 - 4.1e-18 65.2 0.1 3.1e-17 62.3 0.1 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFX05217.1 - 7.8e-07 29.8 0.1 2.7e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 Complex1_LYR-like Aldo_ket_red PF00248.21 EFX05219.1 - 2.8e-38 131.8 0.0 5.9e-28 97.9 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Ku PF02735.16 EFX05220.1 - 8.9e-44 149.6 0.0 2.1e-43 148.4 0.0 1.5 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EFX05220.1 - 4.8e-27 95.2 0.0 7.2e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EFX05220.1 - 6.8e-25 87.6 0.2 1.9e-24 86.1 0.2 1.8 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EFX05220.1 - 1.1e-07 31.5 0.0 3.1e-07 30.0 0.0 1.8 2 0 0 2 2 2 1 SAP domain BCS1_N PF08740.11 EFX05221.1 - 3.5e-53 180.4 1.8 3.5e-53 180.4 1.8 2.7 3 0 0 3 3 2 1 BCS1 N terminal AAA PF00004.29 EFX05221.1 - 7.6e-17 62.0 0.0 9.9e-08 32.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFX05221.1 - 0.0011 18.9 0.0 0.0079 16.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFX05221.1 - 0.003 17.2 0.0 0.0072 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX05221.1 - 0.0052 17.2 2.1 0.0079 16.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFX05221.1 - 0.021 14.6 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PPV_E1_C PF00519.17 EFX05221.1 - 0.038 12.8 0.3 0.12 11.2 0.0 1.9 2 1 0 3 3 3 0 Papillomavirus helicase DUF2052 PF09747.9 EFX05221.1 - 0.14 12.3 27.6 0.62 10.2 13.0 3.4 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 EFX05221.1 - 0.24 9.6 37.6 0.1 10.9 6.2 2.7 3 0 0 3 3 3 0 CDC45-like protein AAA_18 PF13238.6 EFX05221.1 - 0.25 11.9 0.1 0.25 11.9 0.1 3.4 3 1 0 3 3 2 0 AAA domain SAPS PF04499.15 EFX05221.1 - 0.75 8.5 18.1 1 8.1 0.1 2.6 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein TFIIF_alpha PF05793.12 EFX05221.1 - 1 7.9 64.5 0.0094 14.6 30.0 3.1 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM60A PF15396.6 EFX05221.1 - 3.5 7.6 23.4 1.2 9.1 13.9 2.6 2 0 0 2 2 2 0 Protein Family FAM60A Cu_amine_oxid PF01179.20 EFX05222.1 - 8.1e-158 525.6 0.0 1.1e-157 525.2 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Prefoldin_2 PF01920.20 EFX05222.1 - 2.5e-21 75.6 4.3 4.9e-21 74.7 4.3 1.5 1 0 0 1 1 1 1 Prefoldin subunit Cu_amine_oxidN2 PF02727.16 EFX05222.1 - 1.3e-05 25.3 0.1 2.6e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EFX05222.1 - 2.1e-05 24.8 0.0 6.2e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Vfa1 PF08432.10 EFX05222.1 - 1.2 9.5 5.7 1.9 8.8 5.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AAA_23 PF13476.6 EFX05222.1 - 5.6 7.4 6.8 9 6.7 6.8 1.2 1 0 0 1 1 1 0 AAA domain 14-3-3 PF00244.20 EFX05223.1 - 1.3e-06 28.1 0.1 3.6e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 14-3-3 protein DUF3493 PF11998.8 EFX05224.1 - 0.36 11.0 3.0 1.9 8.7 0.1 2.8 3 0 0 3 3 3 0 Low psii accumulation1 / Rep27 Amidoligase_2 PF12224.8 EFX05225.1 - 2.3e-19 70.0 0.0 1.5e-14 54.3 0.0 2.1 2 0 0 2 2 2 2 Putative amidoligase enzyme Vma12 PF11712.8 EFX05226.1 - 1.3e-41 142.0 0.0 5.2e-41 140.0 0.0 2.0 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase zf-C2H2_3 PF13878.6 EFX05226.1 - 3.6e-09 36.3 0.2 7.4e-09 35.3 0.2 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO DUF3464 PF11947.8 EFX05226.1 - 0.12 12.1 1.1 0.53 10.0 1.1 2.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 GILT PF03227.16 EFX05227.1 - 5.4e-18 65.2 0.1 9.4e-18 64.4 0.1 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) TLD PF07534.16 EFX05228.1 - 8.4e-26 90.9 0.0 5.9e-25 88.1 0.0 2.0 1 1 0 1 1 1 1 TLD DUF1773 PF08593.10 EFX05228.1 - 2.7e-15 57.2 1.5 4e-15 56.6 0.6 1.8 2 0 0 2 2 2 1 Domain of unknown function FAA_hydrolase PF01557.18 EFX05229.1 - 7.9e-53 179.3 0.0 1.2e-52 178.7 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EFX05229.1 - 2.7e-26 91.8 0.0 4.9e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Ribonuc_L-PSP PF01042.21 EFX05230.1 - 6.1e-34 116.6 0.0 6.8e-34 116.5 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP HPIP PF15226.6 EFX05230.1 - 0.11 12.9 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family SIR2 PF02146.17 EFX05231.1 - 1.2e-30 106.8 0.0 1.8e-30 106.2 0.0 1.3 1 1 0 1 1 1 1 Sir2 family zf-C3HC PF07967.13 EFX05234.1 - 5.2e-37 126.9 0.0 1.7e-34 118.7 0.0 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 EFX05234.1 - 1.3e-25 89.3 1.9 2e-25 88.7 0.1 2.3 2 0 0 2 2 2 1 Rsm1-like BIR PF00653.21 EFX05234.1 - 0.0015 19.2 0.2 0.03 15.0 0.1 2.3 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain MgpC PF05220.12 EFX05234.1 - 0.084 12.2 0.0 0.084 12.2 0.0 1.5 2 0 0 2 2 2 0 MgpC protein precursor Fungal_trans_2 PF11951.8 EFX05235.1 - 3.2e-11 42.7 0.1 6.4e-07 28.5 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05235.1 - 4e-05 23.7 11.0 7.4e-05 22.8 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hamartin PF04388.12 EFX05235.1 - 3.4 6.2 9.0 5.2 5.6 9.0 1.2 1 0 0 1 1 1 0 Hamartin protein Peptidase_M24 PF00557.24 EFX05237.1 - 3.2e-40 138.1 0.0 5.1e-39 134.1 0.0 2.2 1 1 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EFX05237.1 - 6.5e-06 26.8 0.0 1.2e-05 26.0 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain PGI PF00342.19 EFX05238.1 - 3.1e-226 751.7 0.6 3.5e-226 751.5 0.6 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Pkinase PF00069.25 EFX05239.1 - 3.8e-70 236.2 0.0 5e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05239.1 - 1.1e-29 103.6 0.0 1.4e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFX05239.1 - 0.0012 17.9 0.1 0.013 14.5 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFX05239.1 - 0.0017 18.3 0.0 0.0038 17.2 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFX05239.1 - 0.008 15.3 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EFX05239.1 - 0.0094 15.3 0.0 0.018 14.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFX05239.1 - 0.15 11.4 0.5 0.53 9.6 0.2 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Complex1_LYR_2 PF13233.6 EFX05241.1 - 4.1e-22 78.7 0.0 5e-22 78.4 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like DUF2477 PF10631.9 EFX05241.1 - 0.12 13.0 0.1 0.16 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Xan_ur_permease PF00860.20 EFX05242.1 - 5.6e-61 206.4 34.6 1.9e-60 204.6 34.6 1.7 1 1 0 1 1 1 1 Permease family Calreticulin PF00262.18 EFX05243.1 - 1.1e-165 550.9 18.3 1.5e-165 550.5 18.3 1.1 1 0 0 1 1 1 1 Calreticulin family Big_2 PF02368.18 EFX05243.1 - 0.047 13.6 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) Abhydrolase_6 PF12697.7 EFX05244.1 - 9.3e-05 23.1 0.0 0.00049 20.8 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EFX05244.1 - 0.027 14.0 0.0 0.94 8.9 0.0 2.3 1 1 2 3 3 3 0 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EFX05244.1 - 0.041 13.5 0.0 7.1 6.2 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 EFX05244.1 - 0.052 13.2 0.0 0.43 10.2 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase PGAP1 PF07819.13 EFX05244.1 - 0.082 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein bZIP_1 PF00170.21 EFX05245.1 - 3.5e-07 30.2 15.0 3.9e-07 30.1 13.4 2.0 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFX05245.1 - 0.0037 17.3 14.2 0.0037 17.3 14.2 2.7 1 1 1 2 2 2 1 Basic region leucine zipper mCpol PF18182.1 EFX05245.1 - 0.042 14.2 0.1 0.072 13.4 0.1 1.4 1 0 0 1 1 1 0 minimal CRISPR polymerase domain CCDC-167 PF15188.6 EFX05245.1 - 0.092 13.1 5.5 0.22 11.9 5.5 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 ERM PF00769.19 EFX05245.1 - 0.15 11.9 22.3 0.22 11.3 22.3 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family AAA_23 PF13476.6 EFX05245.1 - 0.92 10.0 6.7 1.3 9.5 6.7 1.3 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 EFX05245.1 - 1.2 7.0 5.4 1.5 6.6 5.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_S19 PF00203.21 EFX05246.1 - 9.8e-29 99.1 0.0 1.1e-28 98.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19 Cyclin_N PF00134.23 EFX05247.1 - 9e-10 38.4 0.3 2.3e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain APH PF01636.23 EFX05248.1 - 2.7e-17 63.5 0.1 3.7e-17 63.1 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFX05248.1 - 0.0099 15.5 0.3 0.017 14.7 0.3 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Zds_C PF08632.10 EFX05249.1 - 7.1e-29 99.3 0.7 1.2e-28 98.6 0.7 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF4278 PF14105.6 EFX05249.1 - 0.29 11.6 1.7 1.2 9.6 1.7 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) DUF2456 PF10445.9 EFX05250.1 - 2.1e-16 59.7 1.8 2.1e-16 59.7 1.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2456) PAT1 PF09770.9 EFX05251.1 - 0 1240.2 1.4 0 1239.8 1.4 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Herpes_HEPA PF03324.14 EFX05251.1 - 0.023 15.1 0.0 0.058 13.9 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus DNA helicase/primase complex associated protein SUR7 PF06687.12 EFX05253.1 - 1.2e-28 100.3 15.8 1.6e-28 99.8 15.8 1.2 1 0 0 1 1 1 1 SUR7/PalI family Sporozoite_P67 PF05642.11 EFX05253.1 - 0.18 9.9 0.8 0.22 9.6 0.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4995 PF16386.5 EFX05253.1 - 0.55 10.3 0.1 0.55 10.3 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function Alpha-L-AF_C PF06964.12 EFX05255.1 - 3.9e-27 95.4 0.0 6.1e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Glyco_hydro_44 PF12891.7 EFX05255.1 - 0.034 14.1 1.9 0.14 12.1 1.9 1.9 1 1 0 1 1 1 0 Glycoside hydrolase family 44 MARVEL PF01284.23 EFX05257.1 - 1.2e-09 38.4 2.1 1.6e-09 38.0 2.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain SPC25 PF06703.11 EFX05257.1 - 0.12 12.2 0.3 0.13 12.0 0.3 1.2 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) ERAP1_C PF11838.8 EFX05258.1 - 6.9e-87 291.9 0.0 1.2e-86 291.1 0.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EFX05258.1 - 2.5e-84 282.2 0.6 3.9e-84 281.6 0.2 1.6 2 0 0 2 2 2 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EFX05258.1 - 2.2e-51 174.7 0.3 4.8e-51 173.6 0.1 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain HSP70 PF00012.20 EFX05259.1 - 1.7e-258 858.8 4.4 2e-258 858.6 4.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFX05259.1 - 8.1e-17 61.0 0.0 8e-16 57.7 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EFX05259.1 - 0.0023 17.7 0.0 0.0055 16.5 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EFX05259.1 - 0.012 16.0 1.9 5.3 7.5 0.2 3.1 3 2 0 3 3 3 0 Cell division protein FtsA Hydantoinase_A PF01968.18 EFX05259.1 - 0.031 13.6 0.1 0.06 12.6 0.1 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase StbA PF06406.11 EFX05259.1 - 0.043 13.0 0.0 0.084 12.1 0.0 1.4 1 0 0 1 1 1 0 StbA protein CdiA_C PF18451.1 EFX05259.1 - 0.088 13.0 0.6 1.1 9.6 0.3 3.0 2 1 1 3 3 3 0 Contact-dependent growth inhibition CdiA C-terminal domain MutS_III PF05192.18 EFX05259.1 - 2.8 8.1 4.7 15 5.8 0.6 2.6 2 1 0 2 2 2 0 MutS domain III FAA_hydrolase PF01557.18 EFX05260.1 - 2.3e-60 204.0 0.0 2.8e-60 203.7 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family SBP_bac_6 PF13343.6 EFX05260.1 - 0.042 13.3 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein GCV_T PF01571.21 EFX05261.1 - 1.8e-09 37.3 0.0 2.8e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GMC_oxred_N PF00732.19 EFX05262.1 - 8.1e-59 199.4 0.0 1.1e-58 199.0 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX05262.1 - 2.5e-32 112.4 0.0 5.9e-32 111.2 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFX05262.1 - 3.3e-06 26.5 0.9 0.019 14.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EFX05262.1 - 0.00055 19.1 0.2 0.0014 17.8 0.2 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFX05262.1 - 0.0026 17.9 0.4 0.012 15.9 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFX05262.1 - 0.0057 15.9 0.4 0.013 14.7 0.1 1.6 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EFX05262.1 - 0.012 15.2 2.8 0.06 12.9 2.8 2.0 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX05262.1 - 0.013 14.7 0.1 0.037 13.2 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase VWA PF00092.28 EFX05263.1 - 2.7e-05 24.5 0.0 9.9e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFX05263.1 - 0.0045 17.6 0.0 0.0088 16.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EFX05263.1 - 0.048 13.8 0.0 0.098 12.8 0.0 1.5 1 1 0 1 1 1 0 vWA found in TerF C terminus HET PF06985.11 EFX05265.1 - 0.0074 16.6 0.0 0.021 15.2 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) adh_short PF00106.25 EFX05266.1 - 2.3e-35 121.8 0.2 3.2e-35 121.4 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX05266.1 - 1.4e-26 93.5 0.7 1.8e-26 93.1 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EFX05266.1 - 0.011 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Dynamin_N PF00350.23 EFX05269.1 - 5e-23 82.0 0.0 7e-22 78.3 0.0 2.2 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFX05269.1 - 0.00022 20.5 0.0 0.00059 19.1 0.0 1.7 1 0 0 1 1 1 1 Dynamin central region Roc PF08477.13 EFX05269.1 - 0.022 15.0 0.0 0.27 11.5 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EFX05269.1 - 0.082 12.7 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFX05269.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 EFX05269.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MFS_1 PF07690.16 EFX05270.1 - 1.1e-47 162.7 40.3 1.1e-47 162.7 40.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05270.1 - 8e-11 41.5 17.3 2.2e-10 40.0 17.5 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 EFX05270.1 - 5.5e-07 29.2 8.3 7e-07 28.9 6.9 1.9 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 EFX05270.1 - 0.0029 16.1 2.0 0.0041 15.6 2.0 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector OATP PF03137.20 EFX05270.1 - 3.8 5.7 19.1 0.94 7.7 9.5 2.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DIE2_ALG10 PF04922.12 EFX05271.1 - 4.2e-119 398.4 4.8 6.7e-119 397.7 4.8 1.3 1 0 0 1 1 1 1 DIE2/ALG10 family MARVEL PF01284.23 EFX05273.1 - 0.0034 17.4 20.3 0.038 14.0 19.9 2.2 1 1 1 2 2 2 1 Membrane-associating domain Peptidase_M56 PF05569.11 EFX05273.1 - 0.056 12.6 0.3 0.082 12.1 0.3 1.3 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF588 PF04535.12 EFX05273.1 - 0.12 12.1 8.9 0.07 12.9 6.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF588) DUF2070 PF09843.9 EFX05273.1 - 2.8 6.1 7.7 3.8 5.7 7.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HPTransfase PF10090.9 EFX05274.1 - 0.037 13.8 0.1 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain EBP PF05241.12 EFX05275.1 - 6.4e-70 234.2 6.9 7.5e-70 234.0 6.9 1.1 1 0 0 1 1 1 1 Emopamil binding protein CitMHS PF03600.16 EFX05275.1 - 0.49 9.5 7.1 0.04 13.1 2.4 1.5 2 0 0 2 2 2 0 Citrate transporter zf-C2H2_4 PF13894.6 EFX05276.1 - 0.00015 22.3 12.8 0.03 15.1 1.1 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EFX05276.1 - 0.00024 21.3 1.1 0.23 11.6 0.1 2.2 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 EFX05276.1 - 0.00086 19.6 11.9 0.11 13.0 0.5 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFX05276.1 - 0.02 15.3 0.9 0.02 15.3 0.9 3.0 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2HE PF16278.5 EFX05276.1 - 0.15 12.5 0.1 0.51 10.8 0.1 1.9 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 EFX05276.1 - 0.69 10.3 5.6 2.6 8.4 0.3 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf_ZIC PF18366.1 EFX05276.1 - 1.6 8.9 3.4 0.87 9.7 0.5 2.1 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_6 PF13912.6 EFX05276.1 - 2.5 8.2 9.5 0.28 11.2 2.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.16 EFX05277.1 - 1.6e-29 102.9 34.4 9.5e-25 87.3 9.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05277.1 - 3.7e-08 32.7 2.6 3.7e-08 32.7 2.6 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EFX05277.1 - 4 5.7 12.4 0.2 10.0 2.2 3.1 3 1 0 4 4 4 0 Transmembrane secretion effector bZIP_2 PF07716.15 EFX05278.1 - 1.4e-12 47.5 12.4 2.3e-12 46.8 12.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EFX05278.1 - 0.00032 20.7 8.0 0.0006 19.9 8.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor XhlA PF10779.9 EFX05278.1 - 0.00089 19.4 2.6 0.0017 18.5 2.6 1.4 1 0 0 1 1 1 1 Haemolysin XhlA bZIP_Maf PF03131.17 EFX05278.1 - 0.013 16.0 6.6 0.026 15.0 6.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Shugoshin_N PF07558.11 EFX05278.1 - 0.018 14.9 0.1 0.031 14.1 0.1 1.4 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region TSC22 PF01166.18 EFX05278.1 - 0.026 14.8 0.2 0.052 13.9 0.2 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family LCD1 PF09798.9 EFX05278.1 - 0.11 11.0 1.0 0.14 10.7 1.0 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein Matrilin_ccoil PF10393.9 EFX05278.1 - 0.2 11.5 0.8 0.37 10.7 0.8 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin APC_u14 PF16635.5 EFX05278.1 - 0.21 12.1 3.9 0.65 10.6 3.9 1.8 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr FUSC PF04632.12 EFX05278.1 - 0.31 9.5 1.2 0.39 9.2 1.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GIT_CC PF16559.5 EFX05278.1 - 0.52 10.2 2.7 0.34 10.8 0.7 1.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 EFX05278.1 - 1.6 9.2 8.3 0.12 12.8 3.0 1.8 2 0 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 EFX05278.1 - 7.1 7.3 6.3 6.3 7.5 3.1 2.1 1 1 1 2 2 2 0 Initiation control protein YabA PhyH PF05721.13 EFX05279.1 - 1.9e-11 44.6 0.0 2.8e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFX05279.1 - 1e-06 27.8 0.0 0.046 12.5 0.0 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF1479) tRNA-synt_1d PF00750.19 EFX05280.1 - 4.8e-30 104.7 0.0 6.4e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DUF676 PF05057.14 EFX05281.1 - 7.2e-43 146.6 0.0 1.6e-28 99.7 0.0 3.1 2 1 0 2 2 2 2 Putative serine esterase (DUF676) Gly_transf_sug PF04488.15 EFX05282.1 - 6.4e-10 39.5 0.0 1.5e-09 38.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EFX05282.1 - 0.076 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Peptidase_M20 PF01546.28 EFX05283.1 - 6.1e-23 81.6 0.0 2.7e-22 79.5 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EFX05283.1 - 1.1e-08 35.6 15.8 0.041 14.8 0.0 7.4 7 1 0 7 7 7 3 WD domain, G-beta repeat Peptidase_M28 PF04389.17 EFX05283.1 - 0.00017 21.3 0.0 0.00036 20.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 ANAPC4_WD40 PF12894.7 EFX05283.1 - 0.0033 17.7 0.1 2.8 8.3 0.0 4.0 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain M20_dimer PF07687.14 EFX05283.1 - 0.0066 16.3 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain PQQ_3 PF13570.6 EFX05283.1 - 2 9.0 4.6 9.5 6.9 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain Beta_elim_lyase PF01212.21 EFX05284.1 - 2.8e-66 223.8 0.3 6.4e-66 222.6 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EFX05284.1 - 3e-06 26.6 0.0 5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFX05284.1 - 0.09 11.3 0.0 0.18 10.3 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme bZIP_1 PF00170.21 EFX05284.1 - 0.1 12.7 6.6 0.22 11.6 6.6 1.5 1 0 0 1 1 1 0 bZIP transcription factor MFS_1 PF07690.16 EFX05285.1 - 1.6e-14 53.6 17.7 3.7e-14 52.4 17.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 EFX05285.1 - 5.1e-08 32.9 4.2 7.9e-08 32.3 4.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2104 PF09877.9 EFX05285.1 - 0.49 10.7 6.0 0.13 12.6 0.8 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2104) HCMVantigenic_N PF12154.8 EFX05285.1 - 5 7.3 6.9 6.2 7.0 1.2 2.7 2 0 0 2 2 2 0 Glycoprotein B N-terminal antigenic domain of HCMV Pkinase PF00069.25 EFX05286.1 - 3.1e-69 233.3 0.0 4e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05286.1 - 1.2e-32 113.2 0.0 1.7e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EFX05286.1 - 1.1e-10 42.0 2.1 4.2e-10 40.2 2.1 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EFX05286.1 - 3.3e-06 26.3 0.1 4.9e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C2 PF00168.30 EFX05286.1 - 0.017 15.4 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 C2 domain Kinase-like PF14531.6 EFX05286.1 - 0.019 14.3 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HAUS6_N PF14661.6 EFX05287.1 - 3.2e-62 210.1 0.2 6.9e-62 209.0 0.2 1.6 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus DprA_WH PF17782.1 EFX05287.1 - 0.42 10.7 3.7 5.8 7.1 1.8 3.4 2 0 0 2 2 2 0 DprA winged helix domain Hydrolase_4 PF12146.8 EFX05288.1 - 2.2e-13 50.1 0.1 2.9e-13 49.6 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFX05288.1 - 1.2e-11 45.6 6.3 1.2e-11 45.6 6.3 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX05288.1 - 1.1e-10 41.7 0.4 1.5e-10 41.1 0.4 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 EFX05288.1 - 0.00083 18.5 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_2 PF02230.16 EFX05288.1 - 0.0018 18.1 0.1 0.15 11.9 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EFX05288.1 - 0.0021 17.9 0.3 0.0035 17.2 0.3 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 EFX05288.1 - 0.012 15.1 0.0 0.038 13.6 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family AXE1 PF05448.12 EFX05288.1 - 0.023 13.4 0.3 0.097 11.3 0.4 1.8 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Ser_hydrolase PF06821.13 EFX05288.1 - 0.046 13.6 0.4 0.093 12.6 0.4 1.4 1 0 0 1 1 1 0 Serine hydrolase PGAP1 PF07819.13 EFX05288.1 - 0.088 12.5 0.1 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 PGAP1-like protein Mg_trans_NIPA PF05653.14 EFX05289.1 - 1.4e-91 306.7 27.4 1.8e-91 306.3 27.4 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EFX05289.1 - 5.4e-06 26.6 6.6 5.4e-06 26.6 6.6 3.1 3 0 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 EFX05289.1 - 0.0012 18.4 1.4 0.0012 18.4 1.4 2.3 2 0 0 2 2 2 1 Solute carrier family 35 DUF5362 PF17319.2 EFX05289.1 - 0.18 11.7 0.1 0.18 11.7 0.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5362) DUF805 PF05656.14 EFX05289.1 - 9.2 6.7 13.9 4.6 7.7 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Deltameth_res PF16020.5 EFX05289.1 - 9.3 6.2 9.1 0.78 9.7 0.1 3.3 2 1 1 3 3 3 0 Deltamethrin resistance 2-Hacid_dh_C PF02826.19 EFX05291.1 - 1.6e-41 141.6 0.0 2e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX05291.1 - 1.5e-09 37.6 0.0 2e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain DUF3640 PF12342.8 EFX05291.1 - 0.019 14.7 0.4 0.49 10.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3640) NAD_binding_2 PF03446.15 EFX05291.1 - 0.029 14.5 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase MFS_1 PF07690.16 EFX05292.1 - 3e-21 75.8 50.5 2.1e-19 69.7 26.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Mucin PF01456.17 EFX05293.1 - 0.00031 20.8 18.2 0.00031 20.8 18.2 2.4 1 1 1 2 2 2 1 Mucin-like glycoprotein DUF4551 PF15087.6 EFX05293.1 - 0.0015 17.5 5.8 0.0018 17.2 5.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) CFEM PF05730.11 EFX05293.1 - 0.0034 17.4 8.6 0.0098 16.0 8.6 1.8 1 0 0 1 1 1 1 CFEM domain Macoilin PF09726.9 EFX05293.1 - 6.9 5.1 14.8 11 4.5 14.8 1.3 1 0 0 1 1 1 0 Macoilin family Securin PF04856.13 EFX05294.1 - 0.042 13.8 0.0 0.26 11.2 0.0 2.1 2 1 0 2 2 2 0 Securin sister-chromatid separation inhibitor Pribosyltran PF00156.27 EFX05296.1 - 1.5e-15 57.1 0.9 2.1e-15 56.6 0.9 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFX05296.1 - 0.061 12.8 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase COX15-CtaA PF02628.15 EFX05297.1 - 9.4e-108 360.1 12.9 1.2e-107 359.8 12.9 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein PRTase_2 PF15609.6 EFX05297.1 - 0.046 13.2 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase ELFV_dehydrog PF00208.21 EFX05298.1 - 2.5e-85 286.1 5.3 3.1e-85 285.8 5.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EFX05298.1 - 6.2e-51 171.7 0.0 1.3e-50 170.6 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 EFX05298.1 - 0.00039 20.8 0.9 0.00095 19.6 0.9 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding CFEM PF05730.11 EFX05299.1 - 4.4e-12 45.9 7.8 7.4e-12 45.2 7.8 1.4 1 0 0 1 1 1 1 CFEM domain Glyco_hydro_61 PF03443.14 EFX05300.1 - 0.011 15.7 0.5 6 6.7 0.1 2.6 3 0 0 3 3 3 0 Glycosyl hydrolase family 61 NSP2-B_epitope PF14757.6 EFX05300.1 - 0.19 11.4 1.9 0.28 10.8 1.9 1.2 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein ATG22 PF11700.8 EFX05301.1 - 1.9e-110 369.7 17.8 2.2e-110 369.5 17.8 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EFX05301.1 - 2.2e-07 30.1 34.6 0.0025 16.8 0.3 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily S-AdoMet_synt_N PF00438.20 EFX05301.1 - 0.69 10.6 1.8 1.6 9.5 0.1 2.3 3 0 0 3 3 3 0 S-adenosylmethionine synthetase, N-terminal domain ANAPC10 PF03256.16 EFX05303.1 - 8.3e-48 162.5 0.0 1.2e-47 162.0 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Ada3 PF10198.9 EFX05304.1 - 8.5e-58 194.2 0.0 9.9e-57 190.7 0.0 2.4 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 Methyltransf_23 PF13489.6 EFX05306.1 - 1.3e-18 67.4 0.0 3.7e-18 65.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05306.1 - 1.5e-10 41.6 0.0 3.4e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05306.1 - 1.7e-08 35.0 0.0 3.1e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05306.1 - 1.7e-06 28.6 0.0 6e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05306.1 - 6.8e-06 26.0 0.0 5e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX05306.1 - 0.0054 16.3 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EFX05306.1 - 0.0054 16.1 0.0 0.0074 15.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 EFX05306.1 - 0.02 14.4 0.0 0.039 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 EFX05306.1 - 0.065 12.5 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EFX05306.1 - 0.075 12.4 0.0 0.32 10.3 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EFX05306.1 - 0.23 10.8 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EFX05306.1 - 0.23 11.2 0.0 0.35 10.6 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Osteopontin PF00865.18 EFX05308.1 - 6.7 6.1 21.5 9.7 5.6 20.9 1.5 1 1 0 1 1 1 0 Osteopontin Glyco_trans_1_4 PF13692.6 EFX05309.1 - 6.2e-09 36.4 0.0 4.9e-07 30.3 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFX05309.1 - 7.8e-05 23.2 10.4 8.7e-05 23.0 9.1 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EFX05309.1 - 0.024 15.0 0.0 0.049 14.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFX05309.1 - 0.085 12.9 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Mito_carr PF00153.27 EFX05310.1 - 2.8e-29 100.9 0.2 3.7e-15 55.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Rad51 PF08423.11 EFX05311.1 - 4.2e-05 22.9 0.0 6.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Rad51 AAA_24 PF13479.6 EFX05311.1 - 0.045 13.5 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATP-synt_Eps PF04627.13 EFX05312.1 - 2.6e-24 84.9 1.0 3.1e-24 84.7 1.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain RCR PF12273.8 EFX05313.1 - 1.2e-25 90.4 5.5 1.5e-25 90.1 5.5 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Rhabdo_glycop PF00974.18 EFX05313.1 - 0.029 12.8 0.5 0.039 12.4 0.5 1.1 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein DUF4131 PF13567.6 EFX05313.1 - 0.037 13.7 0.3 0.045 13.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) LA-virus_coat PF09220.10 EFX05313.1 - 0.07 11.7 0.2 0.094 11.3 0.2 1.1 1 0 0 1 1 1 0 L-A virus, major coat protein DUF2207 PF09972.9 EFX05313.1 - 0.24 10.1 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4381 PF14316.6 EFX05313.1 - 1.1 9.5 3.2 1.8 8.8 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) She9_MDM33 PF05546.11 EFX05313.1 - 1.3 8.8 2.1 1.8 8.3 1.3 1.5 2 0 0 2 2 2 0 She9 / Mdm33 family Amidohydro_1 PF01979.20 EFX05314.1 - 1.4e-72 244.9 0.0 2.2e-72 244.3 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX05314.1 - 3.6e-07 30.0 9.4 1.8e-06 27.7 0.5 3.4 3 1 1 4 4 4 2 Amidohydrolase family DAD PF02109.16 EFX05315.1 - 8e-51 170.9 2.5 1.2e-50 170.4 2.5 1.3 1 0 0 1 1 1 1 DAD family Pex14_N PF04695.13 EFX05315.1 - 0.018 15.7 4.7 0.026 15.2 4.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AJAP1_PANP_C PF15298.6 EFX05315.1 - 1.3 9.2 14.2 17 5.6 15.2 1.9 2 0 0 2 2 2 0 AJAP1/PANP C-terminus Enolase_C PF00113.22 EFX05316.1 - 1.2e-149 497.4 0.0 1.6e-149 497.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EFX05316.1 - 2.2e-57 192.8 0.1 4e-57 192.0 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EFX05316.1 - 4.6e-06 26.3 0.0 9e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EFX05316.1 - 0.015 14.4 0.3 0.3 10.2 0.2 2.6 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase C-terminus Fungal_trans_2 PF11951.8 EFX05317.1 - 1.1e-50 172.6 0.1 1.7e-50 172.0 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05317.1 - 5.1e-08 32.9 8.4 8.9e-08 32.1 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pmp3 PF01679.17 EFX05318.1 - 4.9e-12 45.8 3.5 8.5e-12 45.1 3.5 1.4 1 0 0 1 1 1 1 Proteolipid membrane potential modulator HCV_capsid PF01543.17 EFX05318.1 - 0.052 13.8 1.0 0.092 13.0 1.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus capsid protein p450 PF00067.22 EFX05320.1 - 2.8e-60 204.4 0.0 3.7e-60 204.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cyclin_N PF00134.23 EFX05322.1 - 1.3e-14 54.0 0.0 2.6e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EFX05322.1 - 4.4e-09 36.9 0.4 1.4e-08 35.2 0.0 2.0 2 0 0 2 2 2 1 Cyclin Mannitol_dh_C PF08125.13 EFX05323.1 - 1.5e-39 136.0 0.1 2.5e-39 135.3 0.1 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EFX05323.1 - 5.9e-20 72.0 0.4 4.4e-19 69.1 0.1 2.1 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.14 EFX05323.1 - 1.2e-05 25.0 0.6 0.00048 19.7 0.2 2.4 1 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF3842 PF12953.7 EFX05323.1 - 0.094 13.1 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) SH3_1 PF00018.28 EFX05324.1 - 5.1e-28 96.4 0.0 6.3e-14 51.3 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EFX05324.1 - 4.9e-18 64.7 0.7 1.5e-08 34.3 0.1 3.1 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 EFX05324.1 - 2.3e-13 50.1 0.0 4.3e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EFX05324.1 - 6.9e-12 44.9 0.0 3.1e-07 30.0 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EFX05324.1 - 8.6e-09 35.2 0.4 1.4e-08 34.5 0.4 1.3 1 0 0 1 1 1 1 PB1 domain Rad60-SLD PF11976.8 EFX05324.1 - 0.015 15.1 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Oxidored_FMN PF00724.20 EFX05325.1 - 9.9e-36 123.7 0.0 1.3e-35 123.3 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family p450 PF00067.22 EFX05326.1 - 2.7e-49 168.2 0.0 8.7e-41 140.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 DUF1729 PF08354.10 EFX05327.1 - 1e-159 531.1 0.0 1.8e-159 530.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EFX05327.1 - 2.6e-88 296.6 0.0 7.9e-87 291.7 0.0 2.9 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 EFX05327.1 - 1.5e-53 180.6 1.3 2.8e-53 179.7 0.1 2.2 2 0 0 2 2 2 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 EFX05327.1 - 8.3e-38 128.7 0.0 1.8e-37 127.7 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 EFX05327.1 - 5.2e-37 126.7 0.1 1.1e-35 122.5 0.0 2.5 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta SAT PF16073.5 EFX05327.1 - 3.6e-35 121.9 0.0 1e-34 120.3 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 EFX05327.1 - 2.3e-23 82.8 0.0 7.7e-23 81.1 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Cellulase PF00150.18 EFX05328.1 - 1.2e-52 179.1 5.1 1.4e-52 178.8 5.1 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PBP1_TM PF14812.6 EFX05329.1 - 0.25 11.7 3.0 0.44 11.0 3.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Dopey_N PF04118.14 EFX05330.1 - 2.2e-114 381.7 0.0 5.4e-114 380.4 0.0 1.7 1 0 0 1 1 1 1 Dopey, N-terminal BTAD PF03704.17 EFX05330.1 - 0.07 13.6 1.3 0.65 10.4 0.1 3.2 3 0 0 3 3 3 0 Bacterial transcriptional activator domain Sel1 PF08238.12 EFX05332.1 - 5.1e-10 39.7 8.7 0.0048 17.5 0.0 3.7 3 0 0 3 3 3 3 Sel1 repeat Tannase PF07519.11 EFX05333.1 - 1.6e-91 307.6 0.5 1.9e-91 307.3 0.5 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EFX05333.1 - 0.0024 17.4 0.2 0.033 13.7 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFX05333.1 - 0.035 13.4 0.0 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFX05333.1 - 0.05 13.2 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold NPC1_N PF16414.5 EFX05334.1 - 6.8e-81 271.4 9.3 9.2e-81 271.0 9.3 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EFX05334.1 - 4e-71 240.2 9.4 7e-47 160.0 0.1 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 EFX05334.1 - 7.4e-50 168.7 6.7 7.4e-50 168.7 6.7 3.1 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EFX05334.1 - 0.0003 19.8 8.3 0.0003 19.8 8.3 2.8 2 1 0 2 2 2 1 MMPL family Folate_rec PF03024.14 EFX05334.1 - 0.0003 20.7 1.0 0.0003 20.7 1.0 2.1 2 0 0 2 2 2 1 Folate receptor family ACR_tran PF00873.19 EFX05334.1 - 0.3 8.7 18.5 0.0076 14.0 10.6 1.9 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family DUF2061 PF09834.9 EFX05334.1 - 1.9 9.0 7.2 2.2 8.8 2.5 3.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2061) PI-PLC-X PF00388.19 EFX05335.1 - 2.6e-05 23.8 0.0 0.0013 18.3 0.0 2.2 2 0 0 2 2 2 2 Phosphatidylinositol-specific phospholipase C, X domain DUF2780 PF11075.8 EFX05335.1 - 0.035 14.2 0.1 0.061 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) WD40 PF00400.32 EFX05336.1 - 1.7e-21 76.1 9.5 5.1e-06 27.1 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05336.1 - 0.00099 19.4 0.1 2.9 8.3 0.1 3.8 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Zn_Tnp_IS1595 PF12760.7 EFX05336.1 - 0.0042 17.0 2.7 0.0083 16.1 2.7 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain PD40 PF07676.12 EFX05336.1 - 0.049 13.6 0.1 26 4.9 0.0 4.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Aminotran_1_2 PF00155.21 EFX05337.1 - 3e-61 207.6 0.0 3.5e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFX05337.1 - 0.11 11.0 0.0 0.28 9.7 0.0 1.8 2 1 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Tyosinase_C PF18132.1 EFX05338.1 - 6.4e-31 107.5 0.0 1.1e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Tyrosinase PF00264.20 EFX05338.1 - 7.2e-21 75.5 1.4 1.2e-20 74.8 0.2 1.9 2 0 0 2 2 2 1 Common central domain of tyrosinase Peptidase_C13 PF01650.18 EFX05339.1 - 6.6e-39 134.0 0.1 1.1e-38 133.2 0.1 1.3 1 0 0 1 1 1 1 Peptidase C13 family TFIIIC_delta PF12657.7 EFX05339.1 - 1.4e-15 57.7 0.0 2.6e-14 53.6 0.0 2.3 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EFX05339.1 - 5.7e-13 48.7 0.2 1.4e-12 47.5 0.2 1.6 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex TatD_DNase PF01026.21 EFX05340.1 - 5.4e-46 157.0 0.6 3.2e-45 154.5 0.6 1.9 1 1 0 1 1 1 1 TatD related DNase Peptidase_C50 PF03568.17 EFX05341.1 - 5.3e-159 529.6 0.0 9.5e-159 528.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 EFX05341.1 - 0.00022 20.8 2.4 0.0086 15.5 0.0 3.7 2 1 0 2 2 2 1 CHAT domain TPR_12 PF13424.6 EFX05341.1 - 0.012 15.8 6.1 10 6.5 0.1 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFX05341.1 - 6.8 7.6 6.2 1.9e+02 3.1 1.0 4.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Amidohydro_2 PF04909.14 EFX05342.1 - 3.3e-25 89.5 0.0 4.3e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Peptidase_M20 PF01546.28 EFX05343.1 - 2.2e-31 109.2 0.0 1.3e-30 106.6 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX05343.1 - 4e-14 52.5 0.0 7.2e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFX05343.1 - 0.00027 20.7 0.0 0.0016 18.2 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M28 Cu-oxidase_3 PF07732.15 EFX05344.1 - 1.1e-38 131.9 1.7 9.3e-38 128.9 0.1 2.7 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFX05344.1 - 2.3e-33 114.9 1.1 6.9e-30 103.6 0.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EFX05344.1 - 1.3e-24 87.1 0.0 2.7e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Multicopper oxidase DUF3328 PF11807.8 EFX05344.1 - 0.14 11.9 0.2 0.23 11.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) SnoaL_4 PF13577.6 EFX05345.1 - 3.3e-22 78.9 0.0 3.8e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain Pro-kuma_activ PF09286.11 EFX05346.1 - 1.5e-25 90.2 0.4 4.7e-25 88.6 0.3 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFX05346.1 - 0.0011 18.4 4.3 0.0019 17.5 0.4 2.4 2 0 0 2 2 2 1 Subtilase family Acetyltransf_10 PF13673.7 EFX05347.1 - 1.1e-10 41.5 0.0 1.6e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX05347.1 - 3.3e-08 33.8 0.0 4.7e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX05347.1 - 1.2e-07 32.0 0.0 1.9e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX05347.1 - 0.014 15.3 0.0 0.036 14.0 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 EFX05347.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase TetR_C_14 PF17754.1 EFX05347.1 - 0.13 12.2 0.8 0.24 11.4 0.2 1.8 2 1 0 2 2 2 0 MftR C-terminal domain tRNA-synt_2b PF00587.25 EFX05348.1 - 2.1e-13 50.6 0.0 3.2e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFX05348.1 - 2.5e-08 34.1 0.6 1.1e-07 32.1 0.6 1.9 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Dscam_C PF12355.8 EFX05348.1 - 1.1 10.3 4.5 4.7 8.2 2.6 2.4 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Ribosomal_60s PF00428.19 EFX05349.1 - 1.2 9.8 6.5 2 9.1 0.4 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cmc1 PF08583.10 EFX05350.1 - 4.6e-17 61.8 0.8 5.3e-17 61.6 0.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CnrY PF17524.2 EFX05350.1 - 0.009 16.2 0.1 0.011 16.0 0.1 1.3 1 0 0 1 1 1 1 Anti-sigma factor CnrY NDUF_B7 PF05676.13 EFX05350.1 - 0.054 13.2 0.1 0.073 12.8 0.1 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Hydrolase_6 PF13344.6 EFX05350.1 - 0.12 12.5 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase 4HBT_3 PF13622.6 EFX05351.1 - 3.8e-21 76.5 0.5 5.1e-21 76.0 0.5 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Rhomboid PF01694.22 EFX05354.1 - 1.9e-33 115.6 8.4 1.9e-33 115.6 8.4 1.9 2 0 0 2 2 2 1 Rhomboid family PEPCK_N PF17297.2 EFX05354.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain DUF3093 PF11292.8 EFX05354.1 - 0.62 10.3 6.2 7.2 6.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3093) DUF1129 PF06570.11 EFX05354.1 - 0.79 9.2 4.0 8.8 5.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) VKOR PF07884.14 EFX05354.1 - 6.4 7.0 9.2 0.47 10.7 2.7 2.3 2 1 1 3 3 3 0 Vitamin K epoxide reductase family SH3_1 PF00018.28 EFX05355.1 - 1.4e-10 40.6 0.1 3.2e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFX05355.1 - 2.3e-10 40.1 0.2 6.9e-10 38.6 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EFX05355.1 - 4.9e-07 29.3 0.0 1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NMT_C PF02799.15 EFX05356.1 - 1e-83 280.0 0.0 1.5e-83 279.5 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EFX05356.1 - 4.1e-68 228.3 0.0 6.8e-68 227.5 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EFX05356.1 - 0.0041 17.2 0.1 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Coilin_N PF15862.5 EFX05356.1 - 2.5 7.9 5.1 4.4 7.1 4.0 1.9 2 0 0 2 2 2 0 Coilin N-terminus Grg1 PF11034.8 EFX05357.1 - 6.4e-29 100.0 12.7 7.1e-29 99.8 12.7 1.0 1 0 0 1 1 1 1 Glucose-repressible protein Grg1 Mannosyl_trans3 PF11051.8 EFX05358.1 - 2.3e-55 187.9 0.0 6.4e-34 117.6 0.0 2.1 1 1 1 2 2 2 2 Mannosyltransferase putative MFS_1 PF07690.16 EFX05359.1 - 2.1e-47 161.8 34.5 2.1e-47 161.8 34.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05359.1 - 9.9e-14 51.0 1.8 9.9e-14 51.0 1.8 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFX05359.1 - 7.2e-05 21.4 6.9 0.0001 20.9 1.9 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF4110 PF13422.6 EFX05360.1 - 1.6e-30 105.0 0.2 1.6e-30 105.0 0.2 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) WLM PF08325.10 EFX05360.1 - 5.1e-26 91.9 0.0 5.1e-26 91.9 0.0 3.8 5 0 0 5 5 5 1 WLM domain Kelch_3 PF13415.6 EFX05360.1 - 1.2e-20 73.2 12.8 3.3e-08 33.6 0.3 5.3 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EFX05360.1 - 4.7e-19 68.1 21.8 9.3e-07 28.8 0.0 6.7 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFX05360.1 - 1.9e-14 53.3 3.8 0.0032 17.7 0.1 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EFX05360.1 - 1.2e-13 50.7 9.1 7.3e-07 29.0 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EFX05360.1 - 4.1e-13 48.7 4.7 0.0086 16.0 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFX05360.1 - 8.5e-09 34.9 1.3 0.0019 17.7 0.0 4.8 4 0 0 4 4 4 2 Kelch motif DUF45 PF01863.17 EFX05360.1 - 1.5e-05 25.1 1.7 1.5e-05 25.1 1.7 2.1 2 0 0 2 2 2 1 Protein of unknown function DUF45 zf-RING_10 PF16685.5 EFX05360.1 - 0.46 10.7 3.7 1.1 9.4 3.7 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 ADH_N_2 PF16884.5 EFX05362.1 - 1.5e-27 95.6 0.0 2.5e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFX05362.1 - 4.5e-18 65.5 0.0 8e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX05362.1 - 1.3e-07 32.8 0.0 2.8e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAAA-beta PF15508.6 EFX05362.1 - 0.11 12.9 0.0 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase NAD_kinase PF01513.21 EFX05363.1 - 2.2e-64 217.5 0.0 3.7e-64 216.7 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EFX05363.1 - 0.043 13.4 0.0 0.64 9.6 0.0 2.3 1 1 1 2 2 2 0 Diacylglycerol kinase catalytic domain DUF3597 PF12200.8 EFX05363.1 - 0.12 12.9 0.4 0.12 12.9 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Clr5 PF14420.6 EFX05364.1 - 8.4e-18 64.3 0.8 1.7e-17 63.4 0.4 1.8 2 0 0 2 2 2 1 Clr5 domain DUF3368 PF11848.8 EFX05364.1 - 0.039 13.7 0.0 0.086 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) CAP59_mtransfer PF11735.8 EFX05365.1 - 1.5e-47 162.3 0.0 2.1e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DEAD PF00270.29 EFX05366.1 - 5.5e-40 137.0 0.0 1.3e-39 135.8 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX05366.1 - 3.8e-29 101.3 0.0 9.8e-29 99.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GAGA_bind PF06217.12 EFX05366.1 - 0.00041 20.7 5.3 0.0011 19.3 1.7 2.5 2 0 0 2 2 2 1 GAGA binding protein-like family ResIII PF04851.15 EFX05366.1 - 0.0035 17.3 0.0 0.048 13.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CPSF100_C PF13299.6 EFX05366.1 - 0.8 9.9 16.6 0.12 12.6 5.0 3.5 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 EFX05366.1 - 2.2 7.5 33.6 0.22 10.8 1.5 2.9 3 0 0 3 3 3 0 BUD22 SAPS PF04499.15 EFX05366.1 - 5.2 5.7 6.6 4.2 6.0 3.6 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Coilin_N PF15862.5 EFX05366.1 - 7.4 6.4 18.4 17 5.2 0.1 2.7 2 0 0 2 2 2 0 Coilin N-terminus TMEM171 PF15471.6 EFX05367.1 - 8 5.3 6.6 14 4.6 6.6 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Nuf2 PF03800.14 EFX05368.1 - 2.1e-36 125.1 0.0 5e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 EFX05368.1 - 4.2e-33 113.9 15.1 4.2e-33 113.9 15.1 3.3 3 0 0 3 3 3 1 Designed helical repeat protein 10 domain DUF515 PF04415.12 EFX05368.1 - 0.13 10.7 3.0 0.19 10.1 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) GIT_CC PF16559.5 EFX05368.1 - 1.1 9.2 11.6 2.6 8.0 1.9 3.8 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor 3HCDH_N PF02737.18 EFX05368.1 - 5.3 6.9 8.8 15 5.4 2.2 2.6 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Troponin PF00992.20 EFX05368.1 - 7.2 6.9 32.2 6.1 7.1 15.6 2.9 3 1 0 3 3 3 0 Troponin Peptidase_M16 PF00675.20 EFX05369.1 - 9.2e-17 61.4 0.2 1.8e-16 60.5 0.2 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFX05369.1 - 3.5e-14 53.2 0.0 6e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain MAD PF05557.13 EFX05370.1 - 5.2e-59 200.3 42.8 1.9e-48 165.3 0.0 2.9 2 1 1 3 3 3 3 Mitotic checkpoint protein NRIP1_repr_3 PF15689.5 EFX05370.1 - 0.3 11.4 3.1 1.5 9.2 0.2 3.2 2 0 0 2 2 2 0 Nuclear receptor-interacting protein 1 repression 3 XhlA PF10779.9 EFX05370.1 - 0.49 10.6 12.6 0.16 12.2 0.3 4.7 3 1 1 4 4 4 0 Haemolysin XhlA Ribosomal_S7 PF00177.21 EFX05371.1 - 0.23 11.1 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e TFIID_30kDa PF03540.13 EFX05372.1 - 1.8e-25 88.6 0.3 2.7e-25 88.1 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.6 EFX05372.1 - 0.039 14.5 1.2 0.11 13.1 1.2 1.7 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 TAF4 PF05236.14 EFX05372.1 - 0.052 13.3 0.0 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Ras PF00071.22 EFX05373.1 - 8e-66 220.6 0.5 9.2e-66 220.4 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX05373.1 - 8.7e-36 122.8 0.5 1.3e-35 122.3 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX05373.1 - 3.4e-16 59.2 0.1 4e-16 59.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFX05373.1 - 1e-05 25.5 0.4 0.13 12.2 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFX05373.1 - 2e-05 24.6 0.0 0.0001 22.3 0.0 1.9 1 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX05373.1 - 0.0001 21.9 0.3 0.0003 20.4 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFX05373.1 - 0.00026 20.4 0.1 0.00033 20.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFX05373.1 - 0.00035 20.0 0.0 0.00047 19.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFX05373.1 - 0.0018 17.8 0.1 0.01 15.4 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 EFX05373.1 - 0.0025 18.2 0.1 0.21 12.0 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX05373.1 - 0.0086 16.5 0.0 0.011 16.1 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain LANC_like PF05147.13 EFX05373.1 - 0.027 13.0 0.1 0.11 11.0 0.0 2.0 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein AAA_22 PF13401.6 EFX05373.1 - 0.039 14.2 0.0 0.069 13.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EFX05373.1 - 0.052 12.8 0.0 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 Septin AAA_29 PF13555.6 EFX05373.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 EFX05373.1 - 0.068 12.6 0.0 0.21 11.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.14 EFX05373.1 - 0.075 13.0 0.0 0.13 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EFX05373.1 - 0.088 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EFX05373.1 - 0.1 13.1 0.1 0.17 12.4 0.1 1.6 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 EFX05373.1 - 0.11 12.2 0.1 0.97 9.2 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EFX05373.1 - 0.18 11.4 0.1 1.5 8.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain Glyco_hydro_72 PF03198.14 EFX05374.1 - 1e-112 376.5 0.1 1.3e-112 376.2 0.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EFX05374.1 - 2.3e-05 24.0 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 EFX05375.1 - 2.2e-29 102.6 0.0 3.1e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05375.1 - 6.6e-11 42.0 0.0 9.1e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-binding PF00249.31 EFX05377.1 - 6.5e-16 58.2 0.0 3.5e-09 36.7 0.1 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX05377.1 - 1.9e-13 50.4 0.2 9.8e-09 35.3 0.0 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFX05377.1 - 0.038 14.2 0.0 6.2 7.1 0.0 2.3 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 DIOX_N PF14226.6 EFX05378.1 - 1.8e-34 119.0 0.0 3.4e-34 118.1 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX05378.1 - 1.4e-11 44.8 0.0 2.6e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TfoX_N PF04993.13 EFX05378.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 TfoX N-terminal domain Glyco_hydro_47 PF01532.20 EFX05379.1 - 3e-155 517.6 0.0 1.3e-97 327.6 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 Sld5 PF05916.11 EFX05379.1 - 9.2e-23 80.8 0.0 2.4e-22 79.5 0.0 1.8 1 0 0 1 1 1 1 GINS complex protein CLU PF13236.6 EFX05380.1 - 3.3e-76 256.0 0.0 5.6e-76 255.2 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFX05380.1 - 5.5e-53 179.6 0.0 1.3e-52 178.4 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EFX05380.1 - 1.4e-25 89.4 11.9 2.9e-13 49.9 0.4 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EFX05380.1 - 6.1e-23 81.0 1.3 1.2e-22 80.1 0.1 2.2 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EFX05380.1 - 3e-20 71.4 7.8 7.2e-07 28.9 0.1 5.6 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFX05380.1 - 0.00088 19.3 6.7 0.0018 18.3 0.4 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX05380.1 - 0.015 15.4 0.4 0.015 15.4 0.4 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF727 PF05303.12 EFX05380.1 - 0.017 15.2 0.2 0.055 13.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF727) TPR_17 PF13431.6 EFX05380.1 - 0.09 13.2 2.2 12 6.5 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFX05380.1 - 0.4 11.4 5.3 15 6.5 0.1 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFX05380.1 - 0.42 10.5 4.3 0.18 11.7 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFX05380.1 - 1 10.2 4.0 2 9.2 0.4 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TMEM174 PF15029.6 EFX05381.1 - 0.002 17.9 0.2 0.0026 17.5 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein 174 DSPc PF00782.20 EFX05383.1 - 4.8e-11 42.6 0.0 1e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFX05383.1 - 9.4e-06 25.4 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFX05383.1 - 0.056 13.4 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFX05383.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 EFX05383.1 - 0.18 11.5 0.0 0.5 10.0 0.0 1.7 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Mannosidase_ig PF17786.1 EFX05384.1 - 5.7e-13 49.3 0.0 1.4e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EFX05384.1 - 1e-10 42.3 0.1 2.4e-10 41.0 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EFX05384.1 - 0.0016 18.4 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 EFX05384.1 - 0.0042 16.8 0.1 0.021 14.6 0.0 2.1 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2_C PF02836.17 EFX05384.1 - 0.059 12.5 0.2 0.18 10.8 0.2 1.7 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Ig_GlcNase PF18368.1 EFX05384.1 - 0.075 13.2 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 Exo-beta-D-glucosaminidase Ig-fold domain Pkinase PF00069.25 EFX05385.1 - 2e-60 204.4 0.0 4.4e-60 203.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05385.1 - 1.2e-33 116.6 0.0 3e-33 115.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EFX05385.1 - 7e-19 67.4 0.1 1.2e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 EFX05385.1 - 2e-06 27.0 0.0 3.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFX05385.1 - 6.4e-05 22.4 0.1 0.00014 21.3 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFX05385.1 - 0.00073 18.9 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFX05385.1 - 0.0061 16.5 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.11 EFX05385.1 - 0.021 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) zf-RING_2 PF13639.6 EFX05386.1 - 8.8e-12 45.2 6.7 1.4e-11 44.6 6.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFX05386.1 - 6.9e-08 32.2 6.5 1.1e-07 31.5 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFX05386.1 - 9.3e-08 31.7 0.9 1.7e-07 30.8 0.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EFX05386.1 - 2.2e-07 30.7 4.4 3.5e-07 30.0 4.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFX05386.1 - 1.6e-06 28.3 8.6 5.4e-06 26.6 8.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFX05386.1 - 9.4e-06 25.5 4.1 1.5e-05 24.9 4.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFX05386.1 - 0.0014 18.6 1.0 0.0014 18.6 1.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFX05386.1 - 0.0017 18.2 2.8 0.0026 17.6 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFX05386.1 - 0.0028 17.6 2.5 0.0067 16.5 2.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFX05386.1 - 0.015 15.1 6.1 0.025 14.3 6.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EFX05386.1 - 0.079 12.8 4.9 0.15 11.9 4.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EFX05386.1 - 0.13 12.5 3.2 0.32 11.2 3.2 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 EFX05386.1 - 0.37 10.7 5.6 0.67 9.9 5.6 1.5 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 EFX05386.1 - 0.44 10.2 4.8 0.87 9.3 4.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type OAD_gamma PF04277.13 EFX05386.1 - 0.57 10.8 0.0 0.57 10.8 0.0 3.2 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain RINGv PF12906.7 EFX05386.1 - 0.72 10.0 3.6 1.6 8.9 3.6 1.7 1 1 0 1 1 1 0 RING-variant domain zf-C3HC4_4 PF15227.6 EFX05386.1 - 1.4 9.1 4.8 3 8.1 4.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 EFX05386.1 - 9.3 6.3 8.5 0.3 11.1 1.2 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Acyl-CoA_dh_1 PF00441.24 EFX05387.1 - 3.5e-40 137.7 3.0 5.4e-40 137.0 3.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFX05387.1 - 2.1e-28 99.2 0.2 8e-28 97.4 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFX05387.1 - 2.9e-23 81.9 0.0 5.7e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFX05387.1 - 2.3e-15 57.1 0.4 3.5e-15 56.5 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EFX05387.1 - 0.0042 16.8 0.0 0.012 15.3 0.0 1.7 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal AgrD PF05931.11 EFX05387.1 - 0.031 14.3 0.2 0.55 10.3 0.0 2.8 3 0 0 3 3 3 0 Staphylococcal AgrD protein GSK-3_bind PF05350.12 EFX05389.1 - 0.11 11.8 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding SGL PF08450.12 EFX05390.1 - 9.7e-21 74.5 0.0 1.9e-20 73.5 0.0 1.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFX05390.1 - 3.8e-05 23.8 0.0 0.00018 21.6 0.0 2.0 2 0 0 2 2 2 1 Arylesterase Str_synth PF03088.16 EFX05390.1 - 0.0027 17.8 0.0 0.007 16.5 0.0 1.7 1 1 0 1 1 1 1 Strictosidine synthase NHL PF01436.21 EFX05390.1 - 0.053 13.6 5.6 0.18 11.9 0.0 3.7 4 0 0 4 4 4 0 NHL repeat Reg_prop PF07494.11 EFX05390.1 - 0.071 13.4 0.0 8.4 7.0 0.0 3.5 3 0 0 3 3 3 0 Two component regulator propeller WD40 PF00400.32 EFX05390.1 - 5.6 8.0 5.7 4.7 8.3 0.1 3.7 5 0 0 5 5 5 0 WD domain, G-beta repeat WD40 PF00400.32 EFX05391.1 - 2.1e-17 63.2 11.3 0.00069 20.4 0.0 9.1 8 1 0 8 8 8 5 WD domain, G-beta repeat RRF PF01765.19 EFX05391.1 - 4.4e-07 30.0 0.0 8.1e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Ribosome recycling factor 2OG-FeII_Oxy_3 PF13640.6 EFX05392.1 - 1.3e-09 38.8 0.0 1.8e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1275 PF06912.11 EFX05393.1 - 0.1 12.5 0.8 0.25 11.3 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1275) Pro-kuma_activ PF09286.11 EFX05394.1 - 5.9e-41 140.1 0.0 2e-40 138.4 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Amidohydro_1 PF01979.20 EFX05395.1 - 2.3e-21 76.5 0.0 3.5e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFX05395.1 - 4.5e-13 49.5 0.0 3.9e-05 23.3 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family MFS_1 PF07690.16 EFX05395.1 - 1.1e-12 47.5 30.4 2.2e-12 46.6 26.9 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Abp2 PF09441.10 EFX05396.1 - 1.7e-82 275.6 0.0 3.8e-82 274.4 0.0 1.5 2 0 0 2 2 2 1 ARS binding protein 2 CTP_transf_like PF01467.26 EFX05397.1 - 0.042 14.0 1.5 0.34 11.1 1.5 2.2 1 1 0 1 1 1 0 Cytidylyltransferase-like DUF4177 PF13783.6 EFX05397.1 - 0.18 12.1 0.1 3.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4177) CorA PF01544.18 EFX05398.1 - 3.1e-11 43.2 0.0 3e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Glyoxalase PF00903.25 EFX05399.1 - 2.2e-10 40.8 0.0 2.9e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EFX05399.1 - 0.047 14.5 0.0 0.099 13.4 0.0 1.6 1 1 0 1 1 1 0 Glyoxalase-like domain Arf PF00025.21 EFX05400.1 - 2.1e-41 141.3 0.0 8.6e-36 123.0 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Ras PF00071.22 EFX05400.1 - 1e-16 60.9 0.0 4.6e-14 52.3 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFX05400.1 - 1.1e-12 48.2 0.0 4e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFX05400.1 - 4.1e-07 29.5 0.1 1.4e-06 27.7 0.0 1.8 2 1 0 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFX05400.1 - 8.3e-07 28.6 0.0 1.4e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFX05400.1 - 1.6e-05 25.0 0.1 0.00032 20.8 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFX05400.1 - 5.9e-05 22.6 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFX05400.1 - 0.0044 16.6 0.0 0.016 14.8 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gaa1 PF04114.14 EFX05401.1 - 0.31 10.0 5.5 1 8.3 2.4 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component Glutaredoxin PF00462.24 EFX05402.1 - 6.8e-17 61.4 0.0 2e-16 59.9 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EFX05402.1 - 5.8e-13 48.7 0.0 1.4e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFX05402.1 - 0.0038 17.5 0.0 2.8 8.3 0.0 2.7 1 1 1 2 2 2 2 Thioredoxin-like HyaE PF07449.11 EFX05402.1 - 0.014 15.4 0.0 0.068 13.1 0.0 2.0 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Disulph_isomer PF06491.11 EFX05402.1 - 0.016 15.3 0.0 0.38 10.8 0.0 2.5 2 1 1 3 3 3 0 Disulphide isomerase PsbY PF06298.11 EFX05403.1 - 0.00075 19.4 0.9 0.0013 18.6 0.9 1.3 1 0 0 1 1 1 1 Photosystem II protein Y (PsbY) FeoB_associated PF12669.7 EFX05403.1 - 0.043 14.2 0.4 0.071 13.5 0.4 1.2 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Kelch_5 PF13854.6 EFX05404.1 - 6.4e-06 26.0 2.7 1.8 8.7 0.0 4.2 3 0 0 3 3 3 3 Kelch motif NAM-associated PF14303.6 EFX05404.1 - 0.028 15.1 1.1 4.6 7.9 0.0 3.0 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain Mid2 PF04478.12 EFX05404.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Plasmodium_Vir PF05795.11 EFX05404.1 - 0.087 12.2 0.1 0.18 11.2 0.1 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein His_Phos_1 PF00300.22 EFX05405.1 - 2.6e-13 50.1 0.0 4.5e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_S9 PF00326.21 EFX05405.1 - 4.2e-09 36.2 0.1 1.5e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFX05405.1 - 4.4e-09 36.0 0.1 1.4e-08 34.3 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.12 EFX05405.1 - 1.3e-08 33.9 0.1 2.4e-06 26.5 0.1 2.7 2 1 0 2 2 2 2 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 EFX05405.1 - 2.6e-08 33.8 0.0 4e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 EFX05405.1 - 2.4e-07 30.7 0.4 7.7e-07 29.0 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX05405.1 - 2.9e-06 28.1 5.2 5.2e-06 27.2 5.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EFX05405.1 - 7.2e-05 22.8 0.0 0.0062 16.5 0.0 2.2 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal GIIM PF08388.11 EFX05405.1 - 0.088 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Group II intron, maturase-specific domain DLH PF01738.18 EFX05405.1 - 0.12 11.9 0.0 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family adh_short PF00106.25 EFX05407.1 - 3.7e-30 104.9 0.0 5.2e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX05407.1 - 6.1e-17 62.0 0.0 1.7e-16 60.5 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SMC_Nse1 PF07574.13 EFX05409.1 - 4.8e-58 196.3 0.0 6.2e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EFX05409.1 - 1.8e-12 47.4 7.9 2.8e-12 46.8 7.9 1.3 1 0 0 1 1 1 1 RING-like domain C1_1 PF00130.22 EFX05409.1 - 0.097 12.6 3.1 0.22 11.4 3.1 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HAD_SAK_1 PF10307.9 EFX05409.1 - 0.23 11.2 0.0 0.36 10.6 0.0 1.2 1 0 0 1 1 1 0 HAD domain family 1 in Swiss Army Knife RNA repair proteins zf-HC5HC2H PF13771.6 EFX05409.1 - 0.66 10.3 4.5 1.3 9.3 4.5 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain DEAD PF00270.29 EFX05410.1 - 5.7e-16 58.8 0.0 1.8e-15 57.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EFX05410.1 - 6e-14 52.4 0.0 2.9e-13 50.2 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFX05410.1 - 4.3e-07 30.3 0.0 1.1e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Importin_rep_6 PF18829.1 EFX05410.1 - 0.018 15.2 0.3 0.043 13.9 0.3 1.6 1 0 0 1 1 1 0 Importin repeat 6 RhoGEF PF00621.20 EFX05411.1 - 1.6e-23 83.9 0.0 5.7e-23 82.1 0.0 1.9 2 0 0 2 2 2 1 RhoGEF domain DUF3507 PF12015.8 EFX05411.1 - 3.8e-05 23.5 0.0 7.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Nod1 PF17114.5 EFX05411.1 - 0.02 15.0 0.0 0.052 13.7 0.0 1.7 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 Pyr_redox_2 PF07992.14 EFX05412.1 - 5.4e-42 144.0 4.1 8.6e-42 143.4 4.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 EFX05412.1 - 1e-16 61.0 10.0 2.6e-12 46.9 5.6 2.5 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rieske_2 PF13806.6 EFX05412.1 - 7.1e-16 58.0 0.0 2.6e-15 56.2 0.0 2.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 EFX05412.1 - 3.8e-14 52.4 0.0 3e-13 49.5 0.0 2.5 3 0 0 3 3 3 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EFX05412.1 - 2.7e-13 50.3 6.7 3.3e-12 46.8 2.2 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR_ferr PF03460.17 EFX05412.1 - 6.8e-10 38.7 0.0 1.9e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain NIR_SIR PF01077.22 EFX05412.1 - 8.4e-08 31.9 0.0 4.2e-06 26.3 0.0 2.5 1 1 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rubredoxin_C PF18267.1 EFX05412.1 - 6.8e-05 22.7 0.1 0.081 12.9 0.0 2.9 2 0 0 2 2 2 2 Rubredoxin NAD+ reductase C-terminal domain NAD_binding_9 PF13454.6 EFX05412.1 - 0.0016 18.4 0.7 0.92 9.5 0.0 3.4 2 1 1 3 3 3 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EFX05412.1 - 0.027 14.9 1.0 0.42 11.1 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 EFX05412.1 - 0.04 13.2 3.5 3.5 6.9 0.5 2.7 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EFX05412.1 - 0.055 13.7 1.6 9.5 6.5 0.2 3.2 3 0 0 3 3 3 0 TrkA-N domain NAD_binding_8 PF13450.6 EFX05412.1 - 0.1 12.9 0.5 2.9 8.2 0.1 3.0 3 0 0 3 3 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFX05412.1 - 0.13 11.5 0.0 0.7 9.1 0.0 2.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ATP19 PF11022.8 EFX05413.1 - 2e-27 95.3 0.0 2.4e-27 95.1 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Abhydrolase_1 PF00561.20 EFX05414.1 - 2.5e-11 43.7 0.0 1.5e-09 37.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX05414.1 - 3.4e-07 31.1 0.0 4.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX05414.1 - 4.3e-06 26.2 0.0 0.0014 17.9 0.0 2.0 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 EFX05414.1 - 0.00072 18.3 0.0 0.0014 17.4 0.0 1.4 1 1 0 1 1 1 1 Ndr family GCP_N_terminal PF17681.1 EFX05415.1 - 3.4e-26 92.6 0.0 5.2e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFX05415.1 - 9.6e-24 84.4 0.0 3e-23 82.8 0.0 1.7 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Tubulin_3 PF14881.6 EFX05416.1 - 1.3e-70 236.7 0.0 2e-70 236.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EFX05416.1 - 8.7e-41 138.9 0.4 1.7e-40 138.0 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EFX05416.1 - 0.021 15.0 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain NOA36 PF06524.12 EFX05416.1 - 8.2 5.7 6.0 14 4.9 6.0 1.3 1 0 0 1 1 1 0 NOA36 protein NGP1NT PF08153.12 EFX05417.1 - 1.1e-41 142.0 0.4 1.1e-41 142.0 0.4 1.8 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EFX05417.1 - 1.6e-19 70.1 0.0 2.9e-15 56.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EFX05417.1 - 3.6e-06 26.6 0.0 1.4e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFX05417.1 - 8.8e-06 25.9 0.0 0.0038 17.3 0.0 3.4 2 1 1 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 EFX05417.1 - 0.00045 20.2 0.0 0.0011 18.9 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EFX05417.1 - 0.0029 17.1 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFX05417.1 - 0.0046 16.5 0.0 0.12 11.9 0.0 2.7 1 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EFX05417.1 - 0.028 13.7 0.0 0.19 11.1 0.0 2.2 3 0 0 3 3 3 0 AIG1 family MMR_HSR1_Xtn PF16897.5 EFX05417.1 - 0.1 12.6 0.0 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Mucin PF01456.17 EFX05418.1 - 1.1 9.3 22.9 0.022 14.8 14.5 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein DnaJ PF00226.31 EFX05419.1 - 2e-23 82.2 3.9 7.3e-23 80.5 3.9 2.1 1 0 0 1 1 1 1 DnaJ domain TcA_RBD PF18518.1 EFX05419.1 - 0.025 14.9 0.2 0.078 13.3 0.1 1.9 2 0 0 2 2 2 0 TcA receptor binding domain zf-HIT PF04438.16 EFX05419.1 - 0.044 13.7 2.9 0.078 12.9 2.9 1.4 1 0 0 1 1 1 0 HIT zinc finger C1_2 PF03107.16 EFX05419.1 - 0.097 13.0 4.8 0.18 12.1 4.8 1.4 1 0 0 1 1 1 0 C1 domain TRM PF02005.16 EFX05420.1 - 9e-107 357.5 0.0 2.1e-106 356.3 0.0 1.6 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Auto_anti-p27 PF06677.12 EFX05420.1 - 0.06 13.5 4.4 0.18 12.0 1.1 2.9 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Mo-co_dimer PF03404.16 EFX05421.1 - 3.8e-58 195.4 0.1 8.1e-58 194.3 0.1 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 EFX05421.1 - 7.1e-57 191.8 0.0 1.2e-56 191.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.24 EFX05421.1 - 2.4e-30 104.8 0.0 4e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFX05421.1 - 4.3e-27 94.9 0.0 3.1e-26 92.2 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EFX05421.1 - 1.9e-21 75.9 0.0 3.8e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EFX05421.1 - 1.6e-05 25.1 0.0 0.019 15.1 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain p450 PF00067.22 EFX05422.1 - 1e-76 258.6 0.0 1.2e-76 258.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-MYND PF01753.18 EFX05423.1 - 0.0001 22.3 5.4 0.00027 20.9 5.4 1.7 1 0 0 1 1 1 1 MYND finger Clr5 PF14420.6 EFX05423.1 - 0.15 12.3 0.1 0.32 11.3 0.1 1.6 1 0 0 1 1 1 0 Clr5 domain zf-C6H2 PF15801.5 EFX05423.1 - 0.15 12.4 2.6 0.39 11.1 2.6 1.8 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Ecl1 PF12855.7 EFX05424.1 - 2.2 9.4 9.1 5.2 8.2 9.2 1.7 1 1 0 1 1 1 0 ECL1/2/3 zinc binding proteins Kri1_C PF12936.7 EFX05425.1 - 2.7e-28 98.0 0.0 2.7e-28 98.0 0.0 4.4 6 0 0 6 6 6 1 KRI1-like family C-terminal Kri1 PF05178.12 EFX05425.1 - 6.4e-27 94.1 18.7 6.4e-27 94.1 18.7 5.8 6 1 1 7 7 7 1 KRI1-like family Acetyltransf_1 PF00583.25 EFX05426.1 - 5.4e-09 36.3 0.1 7.7e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX05426.1 - 0.00035 20.9 0.1 0.00053 20.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFX05426.1 - 0.061 13.3 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RCC1 PF00415.18 EFX05427.1 - 6.1e-08 33.2 5.5 0.0028 18.3 0.2 3.3 2 1 1 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFX05427.1 - 0.00011 21.9 0.6 0.00011 21.9 0.6 2.2 2 1 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat Ribosomal_S5 PF00333.20 EFX05427.1 - 0.012 15.6 0.2 0.023 14.7 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain SH3_9 PF14604.6 EFX05428.1 - 7.3e-26 89.8 5.0 7.5e-13 48.1 0.6 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EFX05428.1 - 1.3e-22 79.2 3.6 1.2e-11 44.1 0.3 2.4 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 EFX05428.1 - 6.3e-17 61.5 0.0 1.5e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 EFX05428.1 - 2.7e-15 55.8 0.4 2e-06 27.3 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain Dynamin_M PF01031.20 EFX05429.1 - 5.2e-110 367.2 0.0 8.2e-110 366.5 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EFX05429.1 - 1.3e-56 191.2 0.0 2.5e-56 190.3 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EFX05429.1 - 7.7e-31 106.1 1.2 7.7e-31 106.1 1.2 1.8 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFX05429.1 - 2e-06 27.9 0.1 0.04 14.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Thioredoxin PF00085.20 EFX05430.1 - 1.7e-61 204.6 6.6 1.9e-30 104.9 0.1 4.2 4 1 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 EFX05430.1 - 1.1e-46 159.0 2.7 9.7e-34 116.9 0.7 3.4 2 2 1 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.17 EFX05430.1 - 2.7e-10 39.9 2.6 4.5e-10 39.1 1.3 1.8 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_7 PF13899.6 EFX05430.1 - 1.6e-09 37.8 0.1 0.00095 19.3 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_8 PF13905.6 EFX05430.1 - 7.3e-09 35.8 0.1 0.046 14.1 0.0 4.3 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EFX05430.1 - 1.1e-08 35.0 2.1 0.015 15.2 0.1 3.6 3 0 0 3 3 3 2 AhpC/TSA family Redoxin PF08534.10 EFX05430.1 - 8.7e-08 32.0 4.1 0.056 13.1 0.0 3.4 3 0 0 3 3 3 3 Redoxin OST3_OST6 PF04756.13 EFX05430.1 - 1.6e-07 31.0 0.1 0.025 13.9 0.0 3.0 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFX05430.1 - 1.2e-06 29.0 0.6 0.045 14.2 0.0 3.5 2 1 0 2 2 2 2 Thioredoxin-like domain ERp29_N PF07912.13 EFX05430.1 - 0.00067 19.8 0.4 3.1 8.0 0.0 4.1 3 2 0 3 3 3 1 ERp29, N-terminal domain Thioredoxin_3 PF13192.6 EFX05430.1 - 0.074 13.1 0.5 0.67 10.0 0.0 2.6 2 1 0 2 2 2 0 Thioredoxin domain Thioredoxin_4 PF13462.6 EFX05430.1 - 0.09 12.9 7.1 0.47 10.6 0.2 3.5 3 1 0 3 3 3 0 Thioredoxin Ribosomal_S17e PF00833.18 EFX05431.1 - 8.1e-60 200.1 0.4 9.3e-60 199.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal S17 Metallophos PF00149.28 EFX05432.1 - 6.3e-35 121.5 0.3 1.1e-34 120.8 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFX05432.1 - 7.8e-16 58.3 0.0 1.3e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain SOG2 PF10428.9 EFX05432.1 - 1.6 7.9 17.0 2.1 7.4 17.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Pex14_N PF04695.13 EFX05433.1 - 0.88 10.2 7.1 0.94 10.1 7.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pro-rich PF15240.6 EFX05433.1 - 1.4 9.2 26.9 1.7 8.9 26.9 1.1 1 0 0 1 1 1 0 Proline-rich DUF2076 PF09849.9 EFX05433.1 - 4.1 7.4 17.1 5.2 7.0 17.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SWI-SNF_Ssr4 PF08549.10 EFX05433.1 - 8.3 4.9 5.3 8.4 4.9 5.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PSDC PF12588.8 EFX05434.1 - 5.6e-55 185.2 0.0 8.3e-55 184.6 0.0 1.3 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 EFX05434.1 - 8.5e-36 123.4 0.0 1.8e-35 122.3 0.0 1.5 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.6 EFX05434.1 - 0.011 15.6 0.1 0.57 10.0 0.2 2.4 2 0 0 2 2 2 0 Biotin-lipoyl like Peptidase_M23 PF01551.22 EFX05434.1 - 0.15 12.3 0.0 0.43 10.8 0.0 1.8 1 0 0 1 1 1 0 Peptidase family M23 Chromo_shadow PF01393.19 EFX05435.1 - 1.9e-19 69.5 0.6 3.6e-15 55.8 0.0 2.7 3 0 0 3 3 3 2 Chromo shadow domain Chromo PF00385.24 EFX05435.1 - 4e-12 45.9 0.0 8.8e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain YukD PF08817.10 EFX05436.1 - 0.00073 20.2 0.0 0.0013 19.4 0.0 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 EFX05436.1 - 0.0036 17.0 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S15 PF00312.22 EFX05437.1 - 4.2e-23 81.4 0.6 3e-22 78.6 0.1 2.4 3 0 0 3 3 3 1 Ribosomal protein S15 zf-C2H2 PF00096.26 EFX05438.1 - 9.6e-06 25.8 14.1 0.00033 20.9 0.6 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX05438.1 - 0.0018 19.0 0.7 0.0018 19.0 0.7 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EFX05438.1 - 0.0074 16.3 0.9 0.017 15.1 0.9 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EFX05438.1 - 0.027 14.8 2.7 0.064 13.6 2.7 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) HCMVantigenic_N PF12154.8 EFX05438.1 - 0.84 9.8 3.9 2.8 8.1 3.9 1.8 1 0 0 1 1 1 0 Glycoprotein B N-terminal antigenic domain of HCMV Antimicrobial_5 PF08026.11 EFX05438.1 - 1.7 8.8 6.1 7.9 6.6 6.1 2.3 1 0 0 1 1 1 0 Bee antimicrobial peptide FOXP-CC PF16159.5 EFX05438.1 - 9.9 6.9 9.1 8.9 7.0 1.6 2.7 1 1 1 2 2 2 0 FOXP coiled-coil domain polyprenyl_synt PF00348.17 EFX05439.1 - 9e-75 251.0 0.0 2e-68 230.2 0.0 2.1 2 0 0 2 2 2 2 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EFX05439.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Kinesin PF00225.23 EFX05440.1 - 6e-112 373.8 0.0 8.7e-112 373.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFX05440.1 - 8.1e-26 90.8 0.0 1.8e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Spc7 PF08317.11 EFX05440.1 - 0.048 12.5 6.2 0.081 11.8 6.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Virulence_RhuM PF13310.6 EFX05440.1 - 0.057 12.7 1.5 0.11 11.7 1.5 1.4 1 0 0 1 1 1 0 Virulence protein RhuM family SIKE PF05769.11 EFX05440.1 - 0.094 12.6 9.1 0.24 11.3 8.4 1.9 1 1 1 2 2 2 0 SIKE family GAS PF13851.6 EFX05440.1 - 0.19 11.0 8.8 0.38 10.1 8.8 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF87 PF01935.17 EFX05440.1 - 0.22 11.6 2.7 0.85 9.7 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain DUF5094 PF17015.5 EFX05440.1 - 1.4 9.0 3.9 3.1 7.9 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) ING PF12998.7 EFX05440.1 - 1.5 9.5 6.9 0.66 10.6 4.1 1.8 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DNA_pol_phi PF04931.13 EFX05440.1 - 2.1 6.4 12.5 3.4 5.7 11.7 1.6 2 0 0 2 2 2 0 DNA polymerase phi MFS_1 PF07690.16 EFX05441.1 - 1e-28 100.3 29.2 1e-28 100.3 29.2 3.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05441.1 - 7.3e-08 31.7 7.2 1.4e-07 30.8 7.2 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 EFX05441.1 - 0.00064 18.4 9.3 0.00064 18.4 9.3 2.1 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 EFX05441.1 - 0.86 8.4 6.1 0.22 10.4 0.6 2.2 2 1 1 3 3 3 0 MFS_1 like family CUE PF02845.16 EFX05443.1 - 0.0063 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF1771 PF08590.10 EFX05443.1 - 0.026 14.9 8.9 0.083 13.3 8.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) TTRAP PF14203.6 EFX05443.1 - 0.09 12.8 0.1 0.9 9.6 0.0 2.2 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein Solute_trans_a PF03619.16 EFX05444.1 - 3.2e-86 289.1 25.4 3.8e-86 288.9 25.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha MMS1_N PF10433.9 EFX05445.1 - 4e-119 398.4 0.0 5.7e-119 397.9 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFX05445.1 - 1.7e-58 198.5 0.0 6.2e-30 104.6 0.0 2.7 2 0 0 2 2 2 2 CPSF A subunit region R3H-assoc PF13902.6 EFX05445.1 - 3.8e-30 105.0 2.3 7.4e-30 104.1 2.3 1.5 1 0 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.22 EFX05445.1 - 0.0073 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 R3H domain ANAPC4_WD40 PF12894.7 EFX05445.1 - 0.0073 16.6 0.0 4.6 7.6 0.0 4.2 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Cation_efflux PF01545.21 EFX05446.1 - 3.4e-49 167.3 4.0 4.5e-49 166.9 4.0 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFX05446.1 - 0.00013 22.0 0.0 0.00041 20.4 0.0 1.9 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Eaf7 PF07904.13 EFX05447.1 - 9.7e-23 80.6 0.0 2.3e-22 79.4 0.0 1.6 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 MARVEL PF01284.23 EFX05448.1 - 0.053 13.5 20.3 0.075 13.1 20.3 1.2 1 0 0 1 1 1 0 Membrane-associating domain 7TMR-DISM_7TM PF07695.11 EFX05448.1 - 0.3 11.0 19.2 1.4 8.8 12.4 2.1 1 1 0 2 2 2 0 7TM diverse intracellular signalling DUF4293 PF14126.6 EFX05448.1 - 3.8 7.7 9.2 1.3 9.3 6.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Methyltransf_23 PF13489.6 EFX05449.1 - 8.4e-23 81.0 0.0 1.4e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05449.1 - 2.6e-11 44.1 0.0 7.3e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05449.1 - 2.3e-10 40.5 0.0 1.9e-09 37.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05449.1 - 1.4e-08 35.4 0.0 1.2e-07 32.4 0.0 2.5 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05449.1 - 3.5e-07 30.8 0.0 1.7e-06 28.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFX05449.1 - 0.00062 19.3 0.0 0.0044 16.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EFX05449.1 - 0.0024 17.6 0.0 0.0077 16.0 0.0 1.7 2 0 0 2 2 2 1 Lysine methyltransferase PrmA PF06325.13 EFX05449.1 - 0.0044 16.5 0.0 0.0079 15.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EFX05449.1 - 0.0048 16.2 0.0 0.041 13.2 0.0 2.3 3 0 0 3 3 3 1 O-methyltransferase domain FtsJ PF01728.19 EFX05449.1 - 0.053 13.6 0.0 0.076 13.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EFX05449.1 - 0.055 12.9 0.0 0.94 8.9 0.0 2.3 2 0 0 2 2 2 0 Putative methyltransferase Xpo1 PF08389.12 EFX05450.1 - 5.1e-28 98.0 2.4 5.1e-27 94.8 0.2 3.4 3 1 1 4 4 4 1 Exportin 1-like protein Adaptin_N PF01602.20 EFX05450.1 - 3.5e-06 25.9 0.5 0.00036 19.2 0.1 2.4 2 0 0 2 2 2 2 Adaptin N terminal region UME PF08064.13 EFX05450.1 - 0.00076 19.4 0.6 0.47 10.4 0.0 3.8 4 0 0 4 4 4 1 UME (NUC010) domain IBN_N PF03810.19 EFX05450.1 - 0.0009 19.1 0.0 0.014 15.3 0.0 2.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain NUC173 PF08161.12 EFX05450.1 - 0.0058 16.3 0.3 9.2 5.9 0.0 4.2 4 0 0 4 4 4 1 NUC173 domain Importin_rep_3 PF18806.1 EFX05450.1 - 0.057 13.5 1.3 0.23 11.5 0.1 2.6 3 0 0 3 3 3 0 Importin 13 repeat DUF1149 PF06619.11 EFX05450.1 - 0.14 12.5 0.1 0.46 10.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1149) GTP_EFTU PF00009.27 EFX05451.1 - 5.3e-56 189.2 0.0 8.1e-56 188.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EFX05451.1 - 1.9e-18 66.3 0.0 3.8e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFX05451.1 - 8.9e-12 44.9 0.0 3.6e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 Elongation factor G C-terminus RF3_C PF16658.5 EFX05451.1 - 7e-06 25.9 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 EFX05451.1 - 0.00024 21.4 0.0 0.0007 19.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFX05451.1 - 0.086 12.9 0.1 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase SRF-TF PF00319.18 EFX05453.1 - 1.4e-22 78.9 0.3 2.1e-22 78.3 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Cu-oxidase_2 PF07731.14 EFX05454.1 - 3.7e-12 46.1 0.6 2.1e-11 43.7 0.0 2.4 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EFX05454.1 - 0.0094 16.1 0.0 0.046 13.8 0.0 2.2 2 0 0 2 2 2 1 Multicopper oxidase EF-hand_9 PF14658.6 EFX05455.1 - 0.02 15.2 0.0 0.6 10.5 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 EFX05455.1 - 0.024 14.5 0.2 3.6 7.5 0.1 3.1 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_7 PF13499.6 EFX05455.1 - 0.07 13.6 0.0 1.5 9.3 0.0 2.5 1 1 0 1 1 1 0 EF-hand domain pair IBR PF01485.21 EFX05456.1 - 3.3e-06 27.2 35.5 5e-05 23.4 8.1 3.6 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFX05456.1 - 0.0024 17.7 2.8 0.0024 17.7 2.8 3.7 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Cation_efflux PF01545.21 EFX05457.1 - 8.5e-51 172.5 7.9 1.1e-50 172.2 7.9 1.1 1 0 0 1 1 1 1 Cation efflux family vATP-synt_AC39 PF01992.16 EFX05458.1 - 3.2e-107 358.9 0.0 3.6e-107 358.7 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Tht1 PF04163.12 EFX05460.1 - 0.0051 15.6 0.1 0.0051 15.6 0.1 3.1 3 0 0 3 3 3 1 Tht1-like nuclear fusion protein zf-RING_2 PF13639.6 EFX05461.1 - 1.9e-10 40.9 9.4 4.6e-10 39.7 9.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFX05461.1 - 8.1e-09 35.1 3.7 8.1e-09 35.1 3.7 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFX05461.1 - 3.2e-07 30.1 8.7 8e-07 28.8 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX05461.1 - 1.9e-05 24.4 8.7 4.4e-05 23.3 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX05461.1 - 5.5e-05 23.0 7.1 0.00012 22.0 7.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFX05461.1 - 9e-05 22.7 7.8 0.00045 20.5 7.8 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFX05461.1 - 0.00011 22.2 5.7 0.00011 22.2 5.7 2.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EFX05461.1 - 0.0017 18.4 1.7 0.0037 17.3 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EFX05461.1 - 0.01 15.6 5.8 0.019 14.8 5.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX05461.1 - 0.011 15.6 7.8 0.024 14.5 7.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 STE2 PF02116.15 EFX05461.1 - 0.099 11.9 1.1 0.15 11.4 1.1 1.1 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR zf-C3HC4_4 PF15227.6 EFX05461.1 - 0.17 12.1 9.5 0.35 11.1 9.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EFX05461.1 - 0.22 11.2 3.4 0.47 10.1 3.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type YdjO PF14169.6 EFX05461.1 - 0.5 10.1 2.7 14 5.5 0.7 3.1 2 1 1 3 3 3 0 Cold-inducible protein YdjO zf-RING_4 PF14570.6 EFX05461.1 - 1.3 8.8 6.8 2.5 8.0 6.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EFX05461.1 - 1.6 8.7 5.7 3.1 7.8 5.7 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3H2C3 PF17122.5 EFX05461.1 - 1.7 8.8 5.0 7.7 6.6 5.0 2.1 1 1 0 1 1 1 0 Zinc-finger FAR1 PF03101.15 EFX05462.1 - 4e-05 24.2 0.1 0.0001 23.0 0.1 1.7 1 0 0 1 1 1 1 FAR1 DNA-binding domain Med9 PF07544.13 EFX05462.1 - 0.0032 17.5 1.5 0.0032 17.5 1.5 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Golgin_A5 PF09787.9 EFX05462.1 - 0.0063 16.0 2.4 0.011 15.2 2.4 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 HIP1_clath_bdg PF16515.5 EFX05462.1 - 0.014 16.0 3.6 0.056 14.1 3.6 2.0 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Nnf1 PF03980.14 EFX05462.1 - 0.023 15.1 2.4 0.055 13.9 2.4 1.7 1 0 0 1 1 1 0 Nnf1 Phosphodiest PF01663.22 EFX05462.1 - 0.031 13.9 0.0 0.074 12.6 0.0 1.5 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase XLF PF09302.11 EFX05462.1 - 0.064 13.4 0.5 0.11 12.6 0.5 1.3 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF3165 PF11364.8 EFX05462.1 - 0.34 11.3 1.4 0.61 10.5 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3165) ApoLp-III PF07464.11 EFX05462.1 - 1.4 9.0 5.5 0.16 12.1 0.7 1.9 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) HIG_1_N PF04588.13 EFX05463.1 - 1.1e-05 25.5 1.9 1.1e-05 25.5 1.9 2.3 3 0 0 3 3 3 1 Hypoxia induced protein conserved region Mersacidin PF16934.5 EFX05464.1 - 0.084 12.7 0.2 0.16 11.8 0.2 1.5 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) Amidase PF01425.21 EFX05466.1 - 3.4e-66 224.1 0.0 5.4e-65 220.1 0.0 2.0 1 1 0 1 1 1 1 Amidase p450 PF00067.22 EFX05467.1 - 1.6e-27 96.4 0.0 1.9e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_2 PF02230.16 EFX05468.1 - 6.2e-26 91.5 0.2 1.1e-15 58.1 0.5 2.9 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFX05468.1 - 3e-08 33.4 0.1 8.7e-08 31.9 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 EFX05468.1 - 0.00046 19.9 0.0 0.00089 19.0 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EFX05468.1 - 0.00053 19.7 0.0 0.002 17.8 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold LIP PF03583.14 EFX05468.1 - 0.0018 17.7 0.0 0.0028 17.1 0.0 1.2 1 0 0 1 1 1 1 Secretory lipase DLH PF01738.18 EFX05468.1 - 0.0021 17.7 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFX05468.1 - 0.011 15.0 0.2 0.082 12.2 0.0 2.2 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFX05468.1 - 0.025 14.4 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EFX05468.1 - 0.037 13.9 0.0 0.055 13.4 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_4 PF08386.10 EFX05468.1 - 0.055 13.6 0.0 0.099 12.8 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein DHO_dh PF01180.21 EFX05469.1 - 2.3e-62 210.9 0.0 3.1e-50 171.1 0.0 2.2 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Mpv17_PMP22 PF04117.12 EFX05469.1 - 3.9e-13 49.4 0.2 1.4e-12 47.7 0.2 2.0 1 0 0 1 1 1 1 Mpv17 / PMP22 family zf-RING_5 PF14634.6 EFX05469.1 - 0.0021 18.0 3.5 0.0067 16.4 3.5 1.8 1 0 0 1 1 1 1 zinc-RING finger domain FMN_dh PF01070.18 EFX05469.1 - 0.0058 15.7 1.0 0.012 14.7 0.2 1.8 2 0 0 2 2 2 1 FMN-dependent dehydrogenase zf-RING_UBOX PF13445.6 EFX05469.1 - 0.0066 16.5 2.3 0.017 15.1 2.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFX05469.1 - 0.0096 15.8 3.2 0.0096 15.8 3.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX05469.1 - 0.023 14.6 4.2 0.093 12.6 4.2 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFX05469.1 - 0.071 13.0 3.8 0.2 11.6 3.8 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFX05469.1 - 6.6 7.2 13.4 0.039 14.3 3.0 2.5 2 0 0 2 2 2 0 Ring finger domain Methyltransf_4 PF02390.17 EFX05470.1 - 1.9e-47 161.0 0.0 1e-44 152.1 0.0 2.1 1 1 1 2 2 2 2 Putative methyltransferase Methyltransf_32 PF13679.6 EFX05470.1 - 0.027 14.5 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05470.1 - 0.036 14.8 0.0 0.095 13.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain FmrO PF07091.11 EFX05470.1 - 0.066 12.7 0.0 0.096 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) MTS PF05175.14 EFX05470.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain GTP_EFTU PF00009.27 EFX05471.1 - 1.5e-56 191.1 0.2 2.7e-56 190.2 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EFX05471.1 - 9.6e-32 108.9 0.0 1.8e-31 108.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EFX05471.1 - 1.9e-28 98.6 0.0 4.4e-28 97.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFX05471.1 - 1.9e-21 75.9 0.0 3.8e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFX05471.1 - 5.8e-16 58.6 0.1 1.3e-15 57.5 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFX05471.1 - 3e-07 30.3 0.0 8.4e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain DUF442 PF04273.13 EFX05471.1 - 0.12 12.5 0.1 5.2 7.2 0.0 3.5 4 0 0 4 4 4 0 Putative phosphatase (DUF442) Egh16-like PF11327.8 EFX05472.1 - 8.4e-21 75.2 2.3 1e-20 74.9 2.3 1.0 1 0 0 1 1 1 1 Egh16-like virulence factor Trehalase PF01204.18 EFX05473.1 - 2e-116 389.8 2.4 2.2e-115 386.4 2.4 2.0 1 1 0 1 1 1 1 Trehalase MFS_1 PF07690.16 EFX05474.1 - 1.4e-26 93.3 48.4 2.2e-26 92.7 48.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05474.1 - 4.3e-06 25.8 10.1 4.3e-06 25.8 10.1 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter Ferric_reduct PF01794.19 EFX05475.1 - 3.1e-21 75.8 17.1 3.1e-21 75.8 17.1 2.1 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EFX05475.1 - 2e-08 34.3 0.0 2.9e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_6 PF08030.12 EFX05475.1 - 2.1e-07 31.2 0.0 2e-05 24.8 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Abhydrolase_3 PF07859.13 EFX05476.1 - 7.4e-51 173.0 1.2 1.8e-50 171.7 0.0 2.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold TPR_MLP1_2 PF07926.12 EFX05476.1 - 3.2e-37 127.5 27.3 3.2e-37 127.5 27.3 18.2 7 4 9 17 17 17 5 TPR/MLP1/MLP2-like protein COesterase PF00135.28 EFX05476.1 - 4.3e-09 35.8 0.0 3.4e-08 32.8 0.0 2.6 1 0 0 1 1 1 1 Carboxylesterase family ADIP PF11559.8 EFX05476.1 - 0.0014 18.7 6.1 0.0014 18.7 6.1 20.0 8 4 12 20 20 20 5 Afadin- and alpha -actinin-Binding Abhydrolase_6 PF12697.7 EFX05476.1 - 0.0019 18.8 8.7 0.0019 18.8 8.7 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family ZapB PF06005.12 EFX05476.1 - 0.0033 17.8 5.9 0.0033 17.8 5.9 27.3 13 9 9 22 22 22 1 Cell division protein ZapB Say1_Mug180 PF10340.9 EFX05476.1 - 0.17 10.7 0.0 0.31 9.9 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase RNA_pol_Rpc82 PF05645.13 EFX05477.1 - 3.6e-42 144.9 0.0 4.2e-40 138.1 0.0 2.2 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EFX05477.1 - 3.5e-16 59.0 0.8 9.2e-14 51.3 0.0 3.5 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EFX05477.1 - 0.00012 21.9 0.0 1.1 9.2 0.0 3.2 2 1 1 3 3 3 2 TFIIE alpha subunit DUF4766 PF15973.5 EFX05477.1 - 0.0043 17.6 4.6 0.044 14.4 3.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4766) HTH_20 PF12840.7 EFX05477.1 - 0.98 9.5 7.6 0.62 10.2 0.4 3.5 3 0 0 3 3 3 0 Helix-turn-helix domain GCP_C_terminal PF04130.13 EFX05478.1 - 1.6e-73 247.9 0.0 2.1e-73 247.5 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFX05478.1 - 2.9e-26 92.8 0.0 6.2e-26 91.7 0.0 1.5 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal Ank_2 PF12796.7 EFX05479.1 - 6.1e-70 231.8 8.0 3.3e-19 69.3 0.6 7.7 3 1 5 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX05479.1 - 2.9e-58 193.5 18.6 6.7e-11 42.5 0.0 9.6 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 EFX05479.1 - 7.2e-56 184.3 29.6 8.2e-07 29.2 0.1 10.5 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 EFX05479.1 - 1.1e-49 165.8 25.7 8.9e-10 38.6 0.1 7.3 2 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX05479.1 - 2.4e-48 156.5 9.8 1.7e-05 24.8 0.1 10.8 12 0 0 12 12 10 9 Ankyrin repeat NACHT PF05729.12 EFX05479.1 - 1.2e-10 41.5 0.1 2.9e-08 33.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EFX05479.1 - 1.9e-07 31.6 1.0 9.1e-07 29.4 0.1 2.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFX05479.1 - 0.00024 21.4 0.0 0.00092 19.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain DUF4432 PF14486.6 EFX05479.1 - 0.00056 18.8 4.0 20 3.8 0.0 6.5 2 1 6 8 8 8 0 Domain of unknown function (DUF4432) AAA PF00004.29 EFX05479.1 - 0.005 17.3 0.0 0.042 14.3 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EFX05479.1 - 0.011 15.7 0.1 0.13 12.1 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EFX05479.1 - 0.1 11.8 4.0 0.1 11.8 0.1 2.4 2 1 1 3 3 3 0 KAP family P-loop domain AAA_14 PF13173.6 EFX05479.1 - 0.16 12.0 0.2 0.86 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain FAD_binding_3 PF01494.19 EFX05480.1 - 4.6e-80 269.5 0.0 5.8e-80 269.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX05480.1 - 0.0075 15.5 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX05480.1 - 0.01 16.0 0.2 0.033 14.4 0.2 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFX05480.1 - 0.077 12.1 0.2 0.15 11.1 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EFX05480.1 - 0.11 11.6 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EFX05480.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EFX05480.1 - 0.65 9.0 2.2 1.5 7.8 0.7 2.1 3 0 0 3 3 3 0 Glucose inhibited division protein A MIF4G PF02854.19 EFX05482.1 - 4.3e-44 150.7 0.0 1.8e-20 73.5 0.0 3.4 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 EFX05482.1 - 1e-41 142.8 6.5 1e-41 142.8 6.5 3.5 3 0 0 3 3 3 1 Up-frameshift suppressor 2 TraF PF13728.6 EFX05482.1 - 0.75 9.6 4.2 18 5.1 0.5 2.9 2 0 0 2 2 2 0 F plasmid transfer operon protein Astro_capsid_p PF12226.8 EFX05482.1 - 2.3 7.3 11.5 5.1 6.1 11.5 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF4419 PF14388.6 EFX05483.1 - 8.6e-106 353.7 0.0 1e-105 353.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) UPF0121 PF03661.13 EFX05483.1 - 0.052 13.0 0.1 0.072 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0121) Cytochrom_C1 PF02167.15 EFX05484.1 - 1.5e-92 309.2 0.0 1.9e-92 308.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EFX05484.1 - 0.0086 16.4 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EFX05484.1 - 0.028 15.6 0.0 0.18 13.0 0.0 2.3 2 0 0 2 2 2 0 Cytochrome c GTP_EFTU PF00009.27 EFX05485.1 - 2.6e-33 115.2 1.2 6.2e-33 114.0 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFX05485.1 - 3.8e-19 68.8 0.0 1e-18 67.4 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EFX05485.1 - 7.3e-09 35.9 8.9 5.1e-07 30.0 0.1 3.5 4 0 0 4 4 4 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFX05485.1 - 1.3e-07 31.4 0.1 6e-07 29.3 0.1 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EFX05485.1 - 6.4e-07 29.5 0.2 1.1e-05 25.4 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EFX05485.1 - 0.00029 21.0 0.0 0.001 19.3 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFX05485.1 - 0.0013 18.6 0.1 0.0058 16.4 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Ras PF00071.22 EFX05485.1 - 0.034 13.7 0.0 0.16 11.5 0.0 2.3 1 1 0 1 1 1 0 Ras family AAA_22 PF13401.6 EFX05485.1 - 0.091 13.0 0.3 1.7 8.9 0.3 2.7 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFX05485.1 - 0.11 12.4 0.3 2.3 8.1 0.2 3.2 2 1 0 2 2 2 0 RsgA GTPase Sugar_tr PF00083.24 EFX05486.1 - 7.3e-35 120.7 25.4 2.2e-32 112.5 25.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05486.1 - 6e-21 74.7 40.9 3.1e-12 46.1 13.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily VIT1 PF01988.19 EFX05486.1 - 0.049 13.5 0.1 0.049 13.5 0.1 3.2 3 1 0 3 3 3 0 VIT family Glyco_hydro_18 PF00704.28 EFX05487.1 - 2.4e-63 214.7 1.5 3.8e-63 214.1 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EFX05487.1 - 3e-08 34.0 16.9 3e-08 34.0 16.9 5.4 5 1 0 5 5 5 2 Chitin recognition protein DUF1007 PF06226.13 EFX05487.1 - 0.076 13.0 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) ANAPC4_WD40 PF12894.7 EFX05488.1 - 3.4e-07 30.5 0.0 0.0003 21.0 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EFX05488.1 - 9.1e-05 22.8 2.6 5.6 7.6 0.0 5.3 5 0 0 5 5 5 1 PQQ-like domain CDC45 PF02724.14 EFX05488.1 - 0.012 13.9 7.5 0.016 13.6 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EFX05488.1 - 0.043 13.9 6.7 0.07 13.2 6.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein WD40 PF00400.32 EFX05488.1 - 0.51 11.3 7.0 1.9e+02 3.1 0.1 6.1 7 0 0 7 7 7 0 WD domain, G-beta repeat RNA_polI_A34 PF08208.11 EFX05488.1 - 4.6 7.3 12.9 8.6 6.4 12.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 PI31_Prot_N PF11566.8 EFX05489.1 - 8e-52 175.3 0.0 1e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EFX05489.1 - 3.9e-16 60.0 18.0 3.9e-16 60.0 18.0 2.7 2 1 0 2 2 2 1 PI31 proteasome regulator NUP214 PF16755.5 EFX05490.1 - 3.1e-07 30.0 0.0 5.7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 EFX05490.1 - 8.1e-05 22.9 0.0 0.0014 18.9 0.0 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFX05490.1 - 0.037 14.9 0.0 0.12 13.3 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat MS_channel PF00924.18 EFX05491.1 - 3.5e-19 69.2 1.5 6.5e-19 68.3 1.5 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 EFX05491.1 - 0.0048 16.3 0.0 0.0048 16.3 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 EFX05491.1 - 0.023 14.2 0.1 0.067 12.8 0.1 1.8 1 0 0 1 1 1 0 EF hand Use1 PF09753.9 EFX05491.1 - 0.046 13.4 1.5 0.099 12.4 1.5 1.5 1 0 0 1 1 1 0 Membrane fusion protein Use1 EF-hand_7 PF13499.6 EFX05491.1 - 0.1 13.1 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair DUF3270 PF11674.8 EFX05491.1 - 0.49 10.6 7.9 2.2 8.5 7.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) TauD PF02668.16 EFX05492.1 - 2.4e-26 93.1 0.0 3.9e-26 92.4 0.0 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Rad4 PF03835.15 EFX05493.1 - 3.6e-32 111.1 0.2 1.2e-31 109.3 0.2 1.9 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EFX05493.1 - 7.4e-28 96.8 0.3 1.6e-27 95.7 0.3 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EFX05493.1 - 1e-19 70.1 0.3 2.3e-19 69.0 0.3 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EFX05493.1 - 1.3e-14 54.9 1.3 1.3e-14 54.9 1.3 6.1 6 2 0 6 6 6 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EFX05493.1 - 0.046 14.2 0.0 0.22 12.0 0.0 2.3 1 1 0 1 1 1 0 Transglutaminase-like superfamily Glyco_hydro_7 PF00840.20 EFX05494.1 - 1.1e-99 334.1 0.0 8.6e-98 327.9 0.0 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 7 DHDPS PF00701.22 EFX05495.1 - 4.3e-35 120.8 0.0 6.9e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Smim3 PF17307.2 EFX05495.1 - 0.17 11.4 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 Small integral membrane protein 3 Transferase PF02458.15 EFX05496.1 - 3e-18 65.7 0.0 4.8e-14 51.9 0.0 2.5 2 1 0 2 2 2 2 Transferase family AMP-binding PF00501.28 EFX05497.1 - 1.8e-213 708.8 0.0 7e-76 255.5 0.0 3.8 4 0 0 4 4 4 3 AMP-binding enzyme Condensation PF00668.20 EFX05497.1 - 6.1e-160 532.8 0.0 2.3e-36 125.5 0.0 6.4 6 1 1 7 7 7 6 Condensation domain PP-binding PF00550.25 EFX05497.1 - 3.4e-40 136.2 10.2 3e-08 33.9 0.0 5.8 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFX05497.1 - 2.2e-09 38.2 0.0 0.23 12.5 0.0 4.3 4 0 0 4 4 4 3 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EFX05497.1 - 0.00069 18.4 0.1 0.77 8.3 0.0 3.4 3 0 0 3 3 3 2 Transferase family WES_acyltransf PF03007.16 EFX05497.1 - 0.0014 18.5 0.2 16 5.1 0.0 4.7 5 0 0 5 5 5 2 Wax ester synthase-like Acyl-CoA acyltransferase domain Imm2 PF14426.6 EFX05497.1 - 0.087 12.9 0.4 13 5.9 0.1 3.3 3 0 0 3 3 3 0 Immunity protein Imm2 RsfS PF02410.15 EFX05498.1 - 3.6e-12 46.6 0.0 1.5e-11 44.6 0.0 2.2 2 1 0 2 2 2 1 Ribosomal silencing factor during starvation HTH_23 PF13384.6 EFX05498.1 - 0.036 13.9 1.0 11 6.0 0.1 2.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 EFX05498.1 - 0.057 12.8 3.0 2.1 7.8 0.6 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Rep_fac_C PF08542.11 EFX05499.1 - 2.4e-23 82.4 0.0 5.6e-23 81.2 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFX05499.1 - 7.4e-13 48.6 0.0 2.3e-09 37.3 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EFX05499.1 - 3.1e-12 47.1 0.0 6e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EFX05499.1 - 6.6e-07 29.4 0.0 1.2e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX05499.1 - 2.2e-06 28.2 0.0 0.00022 21.6 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFX05499.1 - 4.8e-05 23.6 0.1 0.07 13.4 0.0 2.5 1 1 1 2 2 2 2 AAA domain RuvB_N PF05496.12 EFX05499.1 - 5.6e-05 22.9 0.0 0.00015 21.6 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 EFX05499.1 - 6.3e-05 22.8 0.0 9.8e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 EFX05499.1 - 0.00026 20.9 0.0 0.00058 19.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFX05499.1 - 0.0021 17.5 0.0 0.027 13.9 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EFX05499.1 - 0.0025 17.8 0.0 0.0045 16.9 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 EFX05499.1 - 0.0025 17.6 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit MeaB PF03308.16 EFX05499.1 - 0.006 15.6 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 EFX05499.1 - 0.0098 15.3 0.0 3.4 7.0 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein AAA_assoc_2 PF16193.5 EFX05499.1 - 0.011 16.1 0.0 0.036 14.4 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain KTI12 PF08433.10 EFX05499.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 EFX05499.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFX05499.1 - 0.014 15.4 0.0 0.059 13.4 0.0 2.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 EFX05499.1 - 0.019 14.9 0.2 0.067 13.1 0.1 1.9 1 1 1 2 2 2 0 NTPase AAA_11 PF13086.6 EFX05499.1 - 0.02 14.7 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EFX05499.1 - 0.042 13.6 0.1 0.58 9.9 0.0 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_19 PF13245.6 EFX05499.1 - 0.047 14.0 0.2 0.13 12.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain MipZ PF09140.11 EFX05499.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 ATPase MipZ AAA_18 PF13238.6 EFX05499.1 - 0.14 12.7 0.0 0.26 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFX05499.1 - 0.18 12.2 0.0 0.75 10.2 0.0 2.1 1 1 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EFX05499.1 - 0.23 10.7 0.2 3.8 6.7 0.2 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mif2_N PF15624.6 EFX05500.1 - 3.6e-39 134.6 0.9 3.6e-39 134.6 0.9 3.3 2 1 1 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CENP-C_C PF11699.8 EFX05500.1 - 1.5e-32 111.6 0.1 2.2e-32 111.1 0.1 1.3 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 EFX05500.1 - 6.2e-07 29.0 0.0 1.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Adaptin_N PF01602.20 EFX05501.1 - 2.3e-99 333.4 0.0 2.7e-99 333.1 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFX05501.1 - 5.3e-16 59.1 0.1 2.6e-15 56.8 0.0 2.2 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFX05501.1 - 1.8e-10 41.1 6.9 4.1e-05 23.9 0.0 5.4 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 EFX05501.1 - 1.1e-06 28.4 4.0 0.13 12.5 0.0 5.7 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EFX05501.1 - 7.2e-06 26.4 5.1 0.0025 18.3 0.1 5.2 4 1 2 6 6 6 1 HEAT-like repeat VHS PF00790.19 EFX05501.1 - 0.014 15.2 0.1 3.5 7.5 0.0 3.0 4 0 0 4 4 4 0 VHS domain Cohesin_HEAT PF12765.7 EFX05501.1 - 0.036 14.4 0.1 0.84 10.0 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.8 EFX05501.1 - 0.19 11.3 0.0 3.8 7.0 0.0 2.8 3 0 0 3 3 3 0 CLASP N terminal DAO PF01266.24 EFX05502.1 - 8.5e-31 107.8 2.9 1.2e-30 107.3 2.9 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX05502.1 - 0.0041 17.3 0.2 0.0091 16.2 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFX05502.1 - 0.0044 16.3 0.0 0.007 15.6 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFX05502.1 - 0.091 12.0 0.0 0.4 9.9 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX05502.1 - 0.12 11.6 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EFX05503.1 - 7.9e-27 94.1 31.7 7.9e-27 94.1 31.7 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Far-17a_AIG1 PF04750.14 EFX05504.1 - 1.4e-49 168.1 8.0 1.6e-49 167.9 8.0 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF1356 PF07092.12 EFX05504.1 - 0.025 13.9 0.1 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) PGG PF13962.6 EFX05504.1 - 0.065 13.1 1.9 0.23 11.3 1.8 1.9 2 0 0 2 2 2 0 Domain of unknown function Forkhead PF00250.18 EFX05505.1 - 1.5e-34 118.1 0.8 3.7e-34 116.8 0.8 1.7 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EFX05505.1 - 5.9e-10 39.4 0.0 1.1e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain Linker_histone PF00538.19 EFX05505.1 - 0.12 12.8 0.2 0.31 11.4 0.2 1.7 1 0 0 1 1 1 0 linker histone H1 and H5 family Glyco_hydro_18 PF00704.28 EFX05506.1 - 9.7e-55 186.5 0.0 1.1e-54 186.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DHDPS PF00701.22 EFX05507.1 - 1.7e-41 141.8 0.0 2.1e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Hira PF07569.11 EFX05509.1 - 5.4e-83 278.1 0.0 5.4e-83 278.1 0.0 2.1 3 0 0 3 3 3 1 TUP1-like enhancer of split WD40 PF00400.32 EFX05509.1 - 2.4e-32 110.5 19.0 1.6e-05 25.5 0.0 9.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05509.1 - 2.8e-13 50.0 0.4 0.056 13.7 0.1 6.0 4 1 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EFX05509.1 - 2.5e-11 43.1 0.8 2.5e-11 43.1 0.8 2.0 2 0 0 2 2 2 1 HIRA B motif Ge1_WD40 PF16529.5 EFX05509.1 - 0.00015 20.8 2.2 0.63 8.9 0.0 5.0 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFX05509.1 - 0.0056 16.6 0.2 25 4.9 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 EFX05509.1 - 0.018 13.1 0.1 0.084 10.9 0.0 2.1 3 0 0 3 3 3 0 IKI3 family Rhodanese PF00581.20 EFX05510.1 - 1.7e-11 44.6 0.0 2.7e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Rcd1 PF04078.13 EFX05511.1 - 3.6e-126 419.7 5.5 4.1e-126 419.6 5.5 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Yip1 PF04893.17 EFX05512.1 - 5e-12 45.9 16.2 5e-12 45.9 16.2 1.5 1 1 0 1 1 1 1 Yip1 domain AFG1_ATPase PF03969.16 EFX05517.1 - 1.3e-98 330.3 0.0 4.9e-94 315.2 0.0 2.4 2 1 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 EFX05517.1 - 0.00019 21.3 0.1 0.094 12.5 0.0 2.7 2 1 0 2 2 2 2 Bacterial dnaA protein AAA_16 PF13191.6 EFX05517.1 - 0.00019 21.8 0.1 0.13 12.6 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 EFX05517.1 - 0.0011 19.0 0.0 0.0025 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFX05517.1 - 0.0066 16.9 0.0 0.029 14.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX05517.1 - 0.016 15.5 0.0 0.053 13.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFX05517.1 - 0.027 14.5 0.0 0.18 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EFX05517.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE UvrD-helicase PF00580.21 EFX05517.1 - 0.083 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain NACHT PF05729.12 EFX05517.1 - 0.086 12.8 0.0 0.49 10.3 0.0 2.1 2 0 0 2 2 2 0 NACHT domain DCB PF16213.5 EFX05518.1 - 1.2e-46 158.6 4.2 1.5e-45 155.1 2.6 2.7 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EFX05518.1 - 8.5e-40 136.2 0.1 8.5e-40 136.2 0.1 2.8 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 EFX05518.1 - 1.1e-25 90.0 1.8 2.9e-22 78.7 0.7 3.1 3 0 0 3 3 3 2 C-terminal region of Mon2 protein DUF1981 PF09324.10 EFX05518.1 - 2.7e-05 24.0 0.4 0.085 12.7 0.0 4.6 4 0 0 4 4 4 2 Domain of unknown function (DUF1981) HSF_DNA-bind PF00447.17 EFX05519.1 - 2.2e-29 101.9 0.5 3.5e-29 101.3 0.5 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding PLDc_2 PF13091.6 EFX05520.1 - 5.6e-18 65.1 0.0 1.6e-09 37.8 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFX05520.1 - 0.016 15.4 0.5 0.43 10.9 0.1 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif Regulator_TrmB PF11495.8 EFX05520.1 - 0.029 13.6 0.0 6.9 5.8 0.0 2.6 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB FMN_red PF03358.15 EFX05521.1 - 1.5e-08 34.5 0.1 3.4e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFX05521.1 - 3.8e-05 23.5 0.0 5.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EFX05521.1 - 0.0023 18.2 0.1 0.03 14.5 0.1 2.3 1 1 0 1 1 1 1 Flavodoxin MutS_V PF00488.21 EFX05522.1 - 2.4e-67 226.6 0.1 5.1e-67 225.6 0.1 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFX05522.1 - 6.9e-42 143.8 0.1 1.6e-41 142.7 0.1 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EFX05522.1 - 4.3e-33 113.9 0.1 1.6e-32 112.1 0.0 2.0 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EFX05522.1 - 1.1e-13 51.6 0.0 5e-13 49.5 0.0 2.1 1 1 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EFX05522.1 - 6.3e-12 45.7 0.0 1.4e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.6 EFX05522.1 - 0.036 13.8 0.0 0.085 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFX05522.1 - 0.036 14.5 0.1 0.1 13.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 EFX05522.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EFX05522.1 - 0.13 12.0 0.7 0.58 9.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SPT6_acidic PF14632.6 EFX05522.1 - 7.4 7.2 13.3 72 4.1 13.3 2.4 1 1 0 1 1 1 0 Acidic N-terminal SPT6 DEAD PF00270.29 EFX05523.1 - 3.5e-49 167.0 0.0 8.1e-49 165.8 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase DBP10CT PF08147.12 EFX05523.1 - 3.5e-23 81.6 1.4 1e-22 80.1 1.4 1.9 1 0 0 1 1 1 1 DBP10CT (NUC160) domain Helicase_C PF00271.31 EFX05523.1 - 3.6e-23 82.0 0.0 4.8e-22 78.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX05523.1 - 4.9e-07 29.9 0.0 1.4e-06 28.4 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SLY PF12485.8 EFX05523.1 - 0.076 13.7 0.5 0.19 12.4 0.5 1.7 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein GRASP55_65 PF04495.14 EFX05524.1 - 9.3e-48 162.0 0.0 4.2e-46 156.7 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EFX05524.1 - 0.0097 15.7 0.0 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PALP PF00291.25 EFX05525.1 - 2.5e-62 211.0 6.5 2.6e-31 109.1 4.2 2.2 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EFX05525.1 - 4.6e-37 125.7 0.0 6.1e-19 67.6 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Transp_cyt_pur PF02133.15 EFX05526.1 - 7.8e-134 446.8 43.8 9.9e-132 439.8 43.8 2.1 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MARVEL PF01284.23 EFX05527.1 - 0.01 15.8 15.5 0.031 14.3 10.1 2.1 1 1 0 2 2 2 0 Membrane-associating domain GRA6 PF05084.13 EFX05527.1 - 0.53 10.2 3.4 6.3 6.7 0.1 2.4 1 1 1 2 2 2 0 Granule antigen protein (GRA6) adh_short_C2 PF13561.6 EFX05528.1 - 4.4e-53 180.2 8.1 5.6e-53 179.9 8.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX05528.1 - 2.5e-40 138.0 5.3 3.3e-40 137.7 5.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX05528.1 - 2.9e-11 43.6 4.0 4.5e-11 43.0 4.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX05528.1 - 0.0051 16.3 1.4 0.0087 15.6 1.4 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EFX05528.1 - 0.067 12.5 0.2 0.15 11.4 0.1 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PmbA_TldD PF01523.16 EFX05528.1 - 0.29 11.0 3.5 0.47 10.2 3.5 1.4 1 1 0 1 1 1 0 Putative modulator of DNA gyrase EcsC PF12787.7 EFX05530.1 - 1.1 8.9 4.5 13 5.3 2.3 2.7 2 1 0 2 2 2 0 EcsC protein family CoA_binding_2 PF13380.6 EFX05531.1 - 3.1e-26 92.2 0.1 4e-26 91.8 0.1 1.1 1 0 0 1 1 1 1 CoA binding domain NUC153 PF08159.12 EFX05532.1 - 2.1e-11 43.4 1.0 2.1e-11 43.4 1.0 3.5 3 0 0 3 3 3 2 NUC153 domain EF-hand_7 PF13499.6 EFX05533.1 - 7.9e-13 48.7 0.4 1.4e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EFX05533.1 - 6.9e-12 45.5 0.0 1.5e-05 25.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EFX05533.1 - 1.9e-10 39.8 0.6 0.00027 20.6 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EFX05533.1 - 9.3e-10 37.4 0.3 0.001 18.5 0.0 3.6 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EFX05533.1 - 1.8e-08 34.1 0.3 0.00035 20.4 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair HTH_51 PF18558.1 EFX05534.1 - 2.3e-23 81.9 0.0 7.9e-23 80.2 0.0 2.0 2 0 0 2 2 1 1 Helix-turn-helix domain Acyl_transf_1 PF00698.21 EFX05534.1 - 1.6e-19 70.6 0.1 2.7e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EFX05534.1 - 1.9e-15 56.9 0.1 3.9e-15 55.9 0.1 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 EFX05534.1 - 5.3e-15 56.0 0.1 3.4e-14 53.4 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EFX05534.1 - 1.1e-12 48.2 2.3 2.8e-12 46.8 2.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_3 PF07859.13 EFX05534.1 - 5.5e-11 42.7 0.0 2.2e-10 40.8 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Methyltransf_23 PF13489.6 EFX05534.1 - 3.7e-10 39.9 0.0 4.2e-09 36.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05534.1 - 6e-09 36.5 0.0 2.2e-08 34.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_S9 PF00326.21 EFX05534.1 - 1.3e-07 31.4 0.0 0.00013 21.6 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Methyltransf_31 PF13847.6 EFX05534.1 - 1.8e-07 31.1 0.0 5.8e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05534.1 - 1.6e-05 25.5 0.0 5.7e-05 23.7 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Abhydrolase_6 PF12697.7 EFX05534.1 - 1.8e-05 25.5 8.8 2.7e-05 24.9 2.6 3.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX05534.1 - 0.0065 15.8 0.0 0.98 8.6 0.0 2.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DLH PF01738.18 EFX05534.1 - 0.061 12.9 0.0 3.1 7.3 0.0 2.6 2 0 0 2 2 2 0 Dienelactone hydrolase family Thioesterase PF00975.20 EFX05534.1 - 0.071 13.2 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain DUF938 PF06080.12 EFX05534.1 - 0.079 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 EFX05534.1 - 0.086 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.17 EFX05534.1 - 0.098 12.3 0.0 0.22 11.1 0.0 1.5 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_33 PF10017.9 EFX05534.1 - 0.17 11.0 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent AA_permease PF00324.21 EFX05535.1 - 9.6e-128 426.8 37.3 1.2e-127 426.5 37.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX05535.1 - 1.7e-38 132.6 36.8 2.3e-38 132.2 36.8 1.0 1 0 0 1 1 1 1 Amino acid permease Trm112p PF03966.16 EFX05536.1 - 5.3e-13 49.3 0.1 6.5e-13 49.1 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.6 EFX05536.1 - 0.049 14.1 0.4 0.08 13.5 0.4 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain NurA PF09376.10 EFX05537.1 - 0.088 12.5 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 NurA domain FGGY_C PF02782.16 EFX05538.1 - 3e-25 89.1 0.0 7.8e-25 87.8 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFX05538.1 - 1.8e-15 57.2 0.0 1.1e-10 41.5 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Glyco_hydro_76 PF03663.14 EFX05539.1 - 7.1e-123 410.7 12.5 8.7e-123 410.4 12.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFX05539.1 - 0.094 11.8 4.2 0.72 8.9 0.3 2.5 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 PIG-P PF08510.12 EFX05541.1 - 2.8e-49 166.0 0.0 6e-49 165.0 0.0 1.5 1 1 0 1 1 1 1 PIG-P CDC45 PF02724.14 EFX05541.1 - 0.00016 20.1 0.1 0.00016 20.1 0.1 1.3 2 0 0 2 2 2 1 CDC45-like protein MORN PF02493.20 EFX05541.1 - 0.34 10.9 3.5 4.8 7.3 0.1 2.8 2 0 0 2 2 2 0 MORN repeat DPM2 PF07297.12 EFX05541.1 - 0.36 11.2 7.1 0.6 10.5 7.1 1.2 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Cnd2 PF05786.14 EFX05541.1 - 1.6 7.3 9.2 3 6.4 9.2 1.4 1 0 0 1 1 1 0 Condensin complex subunit 2 Bestrophin PF01062.21 EFX05542.1 - 1.1e-33 116.9 0.0 2.4e-33 115.8 0.0 1.4 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Fungal_lectin_2 PF18647.1 EFX05543.1 - 9.1e-44 148.1 1.9 1.8e-43 147.1 1.9 1.5 1 0 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin Lipase_GDSL_2 PF13472.6 EFX05543.1 - 5.5e-09 36.7 6.6 4.2e-08 33.8 1.9 2.9 2 2 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFX05543.1 - 1.4e-07 31.7 0.1 2e-06 27.9 0.1 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PH_RBD PF12068.8 EFX05543.1 - 0.02 14.4 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Rab-binding domain (RBD) FtsK_alpha PF17854.1 EFX05543.1 - 0.039 14.1 0.0 0.089 13.0 0.0 1.5 1 0 0 1 1 1 0 FtsK alpha domain Arg_decarbox_C PF17944.1 EFX05543.1 - 0.041 14.4 0.1 0.098 13.2 0.1 1.6 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension SBF PF01758.16 EFX05544.1 - 1.5e-34 119.3 10.0 4.9e-25 88.4 6.0 2.5 1 1 1 2 2 2 2 Sodium Bile acid symporter family Peptidase_M48_N PF16491.5 EFX05544.1 - 1.4 8.8 0.0 1.4 8.8 0.0 3.7 3 1 0 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices zf-H2C2_2 PF13465.6 EFX05546.1 - 4.3e-06 26.9 11.5 7.7e-06 26.1 1.1 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-Di19 PF05605.12 EFX05546.1 - 0.00022 21.4 4.5 0.00049 20.3 4.5 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EFX05546.1 - 0.00024 21.7 15.1 0.026 15.3 5.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EFX05546.1 - 0.054 14.0 14.6 0.16 12.5 7.3 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EFX05546.1 - 0.4 11.0 8.5 3.8 7.9 0.8 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AMP-binding PF00501.28 EFX05547.1 - 4.7e-69 233.0 0.0 8.5e-69 232.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFX05547.1 - 2.5e-62 210.4 0.0 7.6e-62 208.8 0.0 1.9 2 1 1 3 3 3 1 Male sterility protein adh_short PF00106.25 EFX05547.1 - 2.4e-48 164.2 3.6 2.4e-48 164.2 3.6 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX05547.1 - 3.2e-37 128.3 5.6 6.3e-37 127.4 5.6 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX05547.1 - 6.8e-17 61.9 8.1 2.2e-13 50.5 4.5 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EFX05547.1 - 1.2e-16 60.9 1.1 8.2e-12 45.1 0.0 2.8 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EFX05547.1 - 1.3e-11 44.7 0.0 3.5e-11 43.3 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EFX05547.1 - 2.5e-07 30.0 0.6 0.00095 18.2 0.0 2.9 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFX05547.1 - 6.1e-07 29.5 8.1 2.1e-06 27.8 3.6 3.0 2 1 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFX05547.1 - 0.00029 20.1 1.3 0.04 13.1 0.6 2.6 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFX05547.1 - 0.0017 17.9 0.0 0.87 8.9 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase AMP-binding_C PF13193.6 EFX05547.1 - 0.0044 18.0 0.5 0.021 15.8 0.3 2.5 2 0 0 2 2 1 1 AMP-binding enzyme C-terminal domain THF_DHG_CYH_C PF02882.19 EFX05547.1 - 0.0085 15.4 0.3 0.02 14.2 0.3 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NmrA PF05368.13 EFX05547.1 - 0.014 14.9 6.0 1.4 8.5 0.0 3.1 3 0 0 3 3 3 0 NmrA-like family ADH_zinc_N_2 PF13602.6 EFX05548.1 - 1.3e-18 68.3 0.0 2.6e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFX05548.1 - 6.2e-15 55.3 0.1 1.1e-14 54.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aminotran_1_2 PF00155.21 EFX05549.1 - 1.2e-34 120.0 0.0 1.4e-34 119.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Sec7 PF01369.20 EFX05550.1 - 1.1e-28 100.2 0.2 2.5e-28 99.0 0.0 1.6 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 EFX05550.1 - 1.1e-16 61.2 0.0 3.5e-16 59.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain GN3L_Grn1 PF08701.11 EFX05550.1 - 0.84 9.8 6.5 2.1 8.5 6.5 1.6 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase Spt20 PF12090.8 EFX05550.1 - 1.8 8.1 17.1 3.7 7.1 17.1 1.4 1 0 0 1 1 1 0 Spt20 family DUF3591 PF12157.8 EFX05551.1 - 1.4e-172 574.4 0.5 1.8e-172 573.9 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 EFX05551.1 - 0.012 15.5 1.1 0.032 14.1 1.1 1.8 1 0 0 1 1 1 0 Zinc knuckle Aldedh PF00171.22 EFX05552.1 - 1e-133 446.2 0.1 1.2e-133 446.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ApbA PF02558.16 EFX05553.1 - 5.2e-28 97.6 0.0 1.4e-27 96.2 0.0 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EFX05553.1 - 7.6e-24 84.3 0.0 1.6e-23 83.3 0.0 1.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ABC_membrane PF00664.23 EFX05555.1 - 1.8e-41 142.6 11.0 2.3e-41 142.3 11.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFX05555.1 - 1e-32 113.5 0.0 2.2e-32 112.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFX05555.1 - 4.2e-05 23.1 0.0 0.013 14.9 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFX05555.1 - 0.00021 21.2 0.0 0.0078 16.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFX05555.1 - 0.00042 20.6 0.0 0.0025 18.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX05555.1 - 0.00054 20.4 0.4 0.0016 18.8 0.1 2.0 2 1 0 2 2 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFX05555.1 - 0.0091 15.9 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_24 PF13479.6 EFX05555.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFX05555.1 - 0.018 14.8 0.1 0.069 12.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFX05555.1 - 0.019 15.0 0.0 0.048 13.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.6 EFX05555.1 - 0.022 14.8 0.0 0.13 12.3 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 EFX05555.1 - 0.026 14.8 0.0 0.096 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFX05555.1 - 0.027 14.1 0.3 0.18 11.3 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 EFX05555.1 - 0.087 13.4 0.0 0.3 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFX05555.1 - 0.088 13.0 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFX05555.1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain SbcCD_C PF13558.6 EFX05555.1 - 0.092 13.0 0.8 2.1 8.7 0.6 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EFX05555.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EFX05555.1 - 0.14 12.6 0.0 0.27 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFX05555.1 - 0.16 12.4 0.0 1.4 9.4 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mre11_DNA_bind PF04152.14 EFX05556.1 - 3.2e-52 177.3 0.3 8.8e-52 175.8 0.3 1.8 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EFX05556.1 - 2e-13 51.3 2.9 4.4e-13 50.2 2.1 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Myb_DNA-binding PF00249.31 EFX05556.1 - 1.3e-08 34.9 0.0 3e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 EFX05556.1 - 6.4e-08 32.8 0.0 1.7e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain CagZ PF09053.10 EFX05556.1 - 0.062 12.9 0.0 0.63 9.6 0.0 2.3 2 0 0 2 2 2 0 CagZ Glyco_hydro_18 PF00704.28 EFX05557.1 - 4.1e-65 220.6 0.1 4.9e-65 220.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PBP1_TM PF14812.6 EFX05557.1 - 0.19 12.1 2.6 0.61 10.5 2.6 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GDA1_CD39 PF01150.17 EFX05558.1 - 1.6e-99 333.4 0.0 2.1e-99 333.1 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Herpes_pp85 PF04637.12 EFX05559.1 - 3.9 5.8 5.2 4.4 5.6 5.2 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) IF4E PF01652.18 EFX05560.1 - 8.2e-36 123.2 0.0 1.1e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1151 PF06625.11 EFX05560.1 - 0.075 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) RRN3 PF05327.11 EFX05561.1 - 2.6e-161 538.0 0.1 5.2e-161 537.0 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 LTV PF04180.14 EFX05561.1 - 0.057 13.2 9.0 0.32 10.7 1.0 2.3 2 0 0 2 2 2 0 Low temperature viability protein Ppx-GppA PF02541.16 EFX05562.1 - 5.6e-30 104.8 0.0 1e-27 97.3 0.0 2.1 1 1 0 1 1 1 1 Ppx/GppA phosphatase family StbA PF06406.11 EFX05562.1 - 0.027 13.7 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 StbA protein EutA PF06277.11 EFX05562.1 - 0.19 10.5 0.3 0.29 9.9 0.3 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA DUF5321 PF17254.2 EFX05564.1 - 2e-52 176.8 0.1 2.8e-52 176.4 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5321) WD40 PF00400.32 EFX05565.1 - 1.9e-05 25.3 6.0 0.023 15.5 0.3 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat TFIIA PF03153.13 EFX05565.1 - 0.14 12.2 6.7 0.016 15.2 2.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 EFX05565.1 - 0.16 11.0 7.8 0.33 10.0 7.8 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Nop14 PF04147.12 EFX05565.1 - 0.22 9.7 8.5 0.38 8.9 8.5 1.3 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EFX05565.1 - 1.7 6.7 19.4 2.5 6.1 19.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 EFX05565.1 - 3.1 7.6 12.2 7.9 6.3 12.2 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region TRAP_alpha PF03896.16 EFX05565.1 - 4 6.6 8.3 10 5.2 8.3 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PQ-loop PF04193.14 EFX05566.1 - 5e-40 135.1 8.7 1.7e-20 72.5 1.9 2.7 2 0 0 2 2 2 2 PQ loop repeat LRS4 PF10422.9 EFX05566.1 - 0.58 9.7 4.5 1.2 8.7 4.5 1.4 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 IBR PF01485.21 EFX05567.1 - 4.6e-22 78.0 35.8 8.8e-15 54.7 2.9 4.2 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 EFX05567.1 - 9.2e-14 51.7 0.0 1.7e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EFX05567.1 - 5.2e-05 23.5 7.4 5.2e-05 23.5 7.4 3.7 3 1 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EFX05567.1 - 0.00077 19.4 5.9 0.00077 19.4 5.9 3.8 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFX05567.1 - 0.015 15.2 7.1 0.015 15.2 7.1 4.1 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFX05567.1 - 0.027 14.6 0.6 0.027 14.6 0.6 4.4 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING DUF1633 PF07794.11 EFX05567.1 - 0.028 12.6 3.0 0.039 12.1 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) zf-RING_11 PF17123.5 EFX05567.1 - 0.075 12.8 7.4 0.23 11.2 7.4 1.9 1 0 0 1 1 1 0 RING-like zinc finger FoP_duplication PF13865.6 EFX05567.1 - 5.3 7.7 13.5 11 6.6 13.5 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 zf-RING_6 PF14835.6 EFX05567.1 - 9 6.3 19.9 0.11 12.4 2.3 3.1 3 0 0 3 3 3 0 zf-RING of BARD1-type protein NAD_binding_8 PF13450.6 EFX05568.1 - 2.2e-11 43.8 0.2 5.1e-11 42.6 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EFX05568.1 - 5.2e-09 35.9 0.1 1.2e-07 31.4 0.1 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EFX05568.1 - 2e-08 34.0 0.5 3e-08 33.5 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EFX05568.1 - 1e-06 28.6 1.5 3.4e-05 23.6 0.3 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX05568.1 - 2.3e-06 27.0 0.4 4.8e-06 25.9 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFX05568.1 - 5.5e-06 25.8 0.2 1.1e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFX05568.1 - 2e-05 24.0 0.0 3.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX05568.1 - 8.7e-05 21.9 0.4 0.00019 20.8 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFX05568.1 - 9.8e-05 21.6 0.1 0.00015 21.0 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFX05568.1 - 9.9e-05 21.2 0.7 0.00015 20.6 0.7 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EFX05568.1 - 0.0001 21.7 1.0 0.0002 20.7 1.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFX05568.1 - 0.00096 19.7 0.1 0.0024 18.4 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX05568.1 - 0.0013 17.6 0.3 0.0024 16.8 0.3 1.3 1 0 0 1 1 1 1 Tryptophan halogenase IlvN PF07991.12 EFX05568.1 - 0.0026 17.4 0.1 0.0046 16.5 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lycopene_cycl PF05834.12 EFX05568.1 - 0.035 13.2 0.2 0.055 12.5 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EFX05568.1 - 0.036 13.3 0.1 0.086 12.1 0.1 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EFX05568.1 - 0.053 14.0 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding MCRA PF06100.11 EFX05568.1 - 0.084 11.6 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 MCRA family NAD_binding_9 PF13454.6 EFX05568.1 - 0.17 11.8 0.6 0.33 10.9 0.1 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding C5HCH PF17982.1 EFX05569.1 - 0.084 13.1 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 NSD Cys-His rich domain Pkinase PF00069.25 EFX05570.1 - 0.00014 21.3 0.0 0.00047 19.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain SDH_C PF18317.1 EFX05570.1 - 0.072 12.9 0.2 0.19 11.5 0.2 1.7 1 0 0 1 1 1 0 Shikimate 5'-dehydrogenase C-terminal domain DIOX_N PF14226.6 EFX05571.1 - 1.3e-20 74.3 0.0 7.1e-20 71.9 0.0 2.2 3 0 0 3 3 3 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX05571.1 - 3.2e-11 43.6 0.0 5.3e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CcmD PF04995.14 EFX05572.1 - 0.02 15.0 0.4 0.052 13.6 0.4 1.7 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF3419 PF11899.8 EFX05573.1 - 8.5e-155 515.7 0.0 1.1e-154 515.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EFX05573.1 - 5.3e-14 52.4 0.0 7.4e-13 48.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05573.1 - 3.2e-09 37.4 0.0 2.9e-08 34.3 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05573.1 - 1.9e-08 34.9 0.0 1.1e-06 29.2 0.0 3.3 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05573.1 - 4.1e-07 30.5 0.0 8.2e-05 23.2 0.0 3.6 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05573.1 - 2.2e-05 24.3 0.0 4.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX05573.1 - 0.00021 20.7 0.0 0.021 14.1 0.0 2.3 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EFX05573.1 - 0.0042 16.9 0.0 0.0071 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF4573 PF15140.6 EFX05574.1 - 8.3e-09 35.5 3.9 0.0012 18.6 0.0 4.2 4 1 1 5 5 5 2 Domain of unknown function (DUF4573) DUF4868 PF16162.5 EFX05574.1 - 5.8e-05 23.1 25.3 0.0047 16.9 1.6 6.6 2 1 6 8 8 8 4 Domain of unknown function (DUF4868) CagA PF03507.13 EFX05574.1 - 8.8 6.2 8.3 7 6.5 0.4 4.2 2 1 2 4 4 4 0 CagA exotoxin Zn_clus PF00172.18 EFX05575.1 - 0.00023 21.2 11.7 0.00043 20.4 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phage_Mu_Gam PF07352.12 EFX05575.1 - 0.95 9.4 4.5 0.59 10.0 2.3 1.8 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein MAP65_ASE1 PF03999.12 EFX05575.1 - 3.6 6.2 10.2 7.2 5.2 10.2 1.4 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Cornichon PF03311.14 EFX05576.1 - 2.6e-50 169.8 12.1 3e-50 169.6 12.1 1.0 1 0 0 1 1 1 1 Cornichon protein Rieske PF00355.26 EFX05577.1 - 2.6e-11 43.3 0.0 4.3e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EFX05577.1 - 1.7e-08 34.8 0.6 4.4e-08 33.5 0.1 2.0 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region tRNA_bind PF01588.20 EFX05578.1 - 2.7e-22 78.7 0.1 6.3e-22 77.5 0.1 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EFX05578.1 - 0.0015 18.5 0.1 0.0028 17.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_L12 PF00542.19 EFX05579.1 - 2.4e-20 72.7 5.5 3.9e-20 72.0 3.4 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EFX05579.1 - 1.9e-13 49.9 4.4 1.9e-13 49.9 4.4 3.0 4 1 0 4 4 4 1 Ribosomal protein L7/L12 dimerisation domain ROS_MUCR PF05443.11 EFX05579.1 - 0.014 15.4 1.6 0.032 14.3 0.5 2.1 2 1 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Na_Ca_ex PF01699.24 EFX05581.1 - 8.3e-27 94.0 25.9 1.2e-13 51.3 7.0 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Otopetrin PF03189.13 EFX05581.1 - 0.0041 16.0 4.5 0.0075 15.1 4.5 1.3 1 0 0 1 1 1 1 Otopetrin AA_kinase PF00696.28 EFX05582.1 - 1.6e-35 122.9 0.0 2e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Amino acid kinase family Sda PF08970.10 EFX05582.1 - 0.081 12.7 0.0 0.23 11.2 0.0 1.7 2 0 0 2 2 2 0 Sporulation inhibitor A TPR_1 PF00515.28 EFX05584.1 - 3.1e-05 23.6 7.5 0.17 11.8 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFX05584.1 - 0.00033 21.2 1.6 0.00033 21.2 1.6 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFX05584.1 - 0.0014 18.5 11.0 0.0098 15.9 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFX05584.1 - 0.012 16.1 2.8 0.048 14.2 2.8 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFX05584.1 - 0.017 15.8 3.7 0.017 15.8 3.7 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX05584.1 - 0.03 14.5 0.6 0.092 13.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat FmdA_AmdA PF03069.15 EFX05585.1 - 5.8e-175 581.5 0.0 8.8e-175 581.0 0.0 1.3 1 0 0 1 1 1 1 Acetamidase/Formamidase family EI24 PF07264.11 EFX05585.1 - 1e-09 38.9 3.6 8e-09 36.0 3.6 2.2 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-H2C2_2 PF13465.6 EFX05586.1 - 4.4e-09 36.4 19.6 3e-05 24.2 3.0 4.4 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EFX05586.1 - 2.3e-05 24.6 14.0 0.00055 20.2 4.5 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX05586.1 - 0.063 14.2 3.1 0.063 14.2 3.1 4.3 3 1 1 4 4 4 0 C2H2-type zinc finger FOXP-CC PF16159.5 EFX05586.1 - 0.2 12.3 0.2 0.2 12.3 0.2 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain F-box PF00646.33 EFX05587.1 - 0.00028 20.7 0.0 0.00098 18.9 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFX05587.1 - 0.018 14.9 0.7 0.059 13.3 0.0 2.2 2 0 0 2 2 2 0 F-box-like TRP PF06011.12 EFX05588.1 - 4.2e-136 454.1 15.1 5.9e-136 453.6 15.1 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EFX05588.1 - 1.1e-37 129.5 4.6 1.1e-37 129.5 4.6 1.9 2 0 0 2 2 2 1 ML-like domain Mit_ribos_Mrp51 PF11709.8 EFX05589.1 - 1.1e-131 439.8 0.0 1.3e-131 439.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit NAD_binding_11 PF14833.6 EFX05591.1 - 4.1e-63 211.1 1.6 2e-30 105.6 0.3 2.5 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase SBD_N PF07005.11 EFX05591.1 - 8.1e-54 182.8 0.1 3.4e-53 180.7 0.0 2.0 2 0 0 2 2 2 1 Sugar-binding N-terminal domain NAD_binding_2 PF03446.15 EFX05591.1 - 8e-49 165.8 2.5 3.3e-33 115.1 0.5 3.2 3 0 0 3 3 3 2 NAD binding domain of 6-phosphogluconate dehydrogenase NBD_C PF17042.5 EFX05591.1 - 6.4e-39 134.2 0.3 6.4e-39 134.2 0.3 2.6 3 0 0 3 3 3 1 Nucleotide-binding C-terminal domain F420_oxidored PF03807.17 EFX05591.1 - 1.5e-09 38.3 0.4 4.2e-05 24.1 0.1 3.3 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EFX05591.1 - 6.5e-05 22.4 0.1 0.024 14.0 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh PF00984.19 EFX05591.1 - 7.6e-05 22.8 0.8 0.34 11.1 0.1 3.3 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.18 EFX05591.1 - 0.00021 21.2 0.6 0.00021 21.2 0.6 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 EFX05591.1 - 0.009 16.3 0.0 5.8 7.2 0.0 2.9 2 0 0 2 2 2 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EFX05591.1 - 0.5 9.9 3.2 9 5.8 0.1 3.6 5 0 0 5 5 5 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EFX05591.1 - 2 8.0 8.7 0.23 11.1 0.7 2.7 2 1 1 3 3 3 0 Ketopantoate reductase PanE/ApbA bZIP_1 PF00170.21 EFX05593.1 - 0.0006 19.9 7.3 0.00092 19.3 7.3 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EFX05593.1 - 0.012 15.7 8.3 0.018 15.1 8.3 1.3 1 0 0 1 1 1 0 Basic region leucine zipper PTPA PF03095.15 EFX05595.1 - 3.2e-107 358.4 0.0 1.5e-106 356.2 0.0 1.9 1 1 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Zip PF02535.22 EFX05595.1 - 0.022 14.0 0.3 0.03 13.5 0.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter FAM76 PF16046.5 EFX05595.1 - 0.14 11.5 2.2 0.21 10.9 2.2 1.1 1 0 0 1 1 1 0 FAM76 protein Sporozoite_P67 PF05642.11 EFX05595.1 - 0.52 8.3 6.6 9.6 4.1 7.2 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen NicO PF03824.16 EFX05595.1 - 6.9 5.9 7.1 15 4.8 7.1 1.5 1 0 0 1 1 1 0 High-affinity nickel-transport protein MMS1_N PF10433.9 EFX05596.1 - 3.6e-65 220.5 0.0 1.3e-64 218.7 0.0 1.9 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Glyco_hydro_76 PF03663.14 EFX05597.1 - 5.2e-38 131.5 5.3 4.1e-37 128.6 5.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Reprolysin_3 PF13582.6 EFX05598.1 - 7.7e-05 23.2 0.0 0.00014 22.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EFX05598.1 - 0.0021 18.2 0.1 0.0036 17.5 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Astacin PF01400.24 EFX05598.1 - 0.0055 16.3 0.5 0.21 11.2 0.4 2.9 3 1 0 3 3 3 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 EFX05598.1 - 0.0066 16.1 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EFX05598.1 - 0.053 12.5 0.5 0.12 11.3 0.6 1.6 2 0 0 2 2 2 0 Peptidase M66 Peptidase_M10 PF00413.24 EFX05598.1 - 0.067 13.0 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Matrixin Reprolysin_2 PF13574.6 EFX05598.1 - 0.15 12.0 0.2 0.35 10.7 0.2 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Acetyltransf_3 PF13302.7 EFX05599.1 - 4.6e-18 66.2 0.0 5.9e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX05599.1 - 1.9e-07 31.3 0.0 4.8e-06 26.8 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFX05599.1 - 0.00016 21.6 0.0 0.0069 16.3 0.0 2.3 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 EFX05599.1 - 0.0036 17.0 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX05599.1 - 0.013 15.9 0.0 1.3 9.5 0.0 2.4 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain adh_short PF00106.25 EFX05600.1 - 4.2e-40 137.3 0.2 9.7e-40 136.1 0.2 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX05600.1 - 4.9e-33 114.6 0.3 2.9e-32 112.1 0.3 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX05600.1 - 8.2e-13 48.7 1.4 1e-09 38.6 0.0 2.3 2 1 0 2 2 2 2 KR domain Sacchrp_dh_NADP PF03435.18 EFX05600.1 - 0.00038 20.7 0.2 0.001 19.4 0.2 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFX05600.1 - 0.0021 18.0 1.5 0.0021 18.0 1.5 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EFX05600.1 - 0.011 15.3 0.2 0.022 14.2 0.1 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EFX05600.1 - 0.11 12.7 0.2 0.26 11.6 0.1 1.6 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.14 EFX05600.1 - 0.15 10.8 0.2 0.2 10.3 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Abhydrolase_1 PF00561.20 EFX05601.1 - 0.0062 16.2 0.0 0.0094 15.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX05601.1 - 0.14 11.4 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 WD40 PF00400.32 EFX05602.1 - 8.9e-12 45.3 17.6 0.098 13.6 0.0 6.1 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 EFX05602.1 - 0.11 11.1 3.2 19 3.7 0.1 3.6 3 1 1 4 4 4 0 Nucleoporin Nup120/160 SH3_2 PF07653.17 EFX05603.1 - 0.01 15.5 0.0 0.037 13.7 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain SAC3_GANP PF03399.16 EFX05604.1 - 8.4e-23 81.2 1.1 9.7e-21 74.4 1.2 2.2 1 1 0 1 1 1 1 SAC3/GANP family Bap31 PF05529.12 EFX05605.1 - 6.4e-47 158.8 6.7 8.5e-47 158.4 6.7 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EFX05605.1 - 2.2e-15 56.4 5.9 3.8e-15 55.6 5.9 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain Filament PF00038.21 EFX05605.1 - 0.00021 21.0 0.2 0.00031 20.4 0.2 1.2 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.11 EFX05605.1 - 0.01 14.7 1.1 0.014 14.3 1.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DHR10 PF18595.1 EFX05605.1 - 0.019 15.0 0.7 0.03 14.4 0.7 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Transcrip_act PF04949.13 EFX05605.1 - 0.049 13.5 0.2 0.086 12.7 0.2 1.4 1 0 0 1 1 1 0 Transcriptional activator TRAF_BIRC3_bd PF16673.5 EFX05605.1 - 0.11 12.3 0.2 10 6.0 0.0 2.3 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain She9_MDM33 PF05546.11 EFX05605.1 - 0.11 12.2 0.3 0.23 11.2 0.3 1.5 1 0 0 1 1 1 0 She9 / Mdm33 family DUF3138 PF11336.8 EFX05605.1 - 0.19 10.3 0.4 0.28 9.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DivIC PF04977.15 EFX05605.1 - 0.57 10.0 6.8 1.6 8.6 1.8 3.0 2 1 0 3 3 3 0 Septum formation initiator Coq4 PF05019.13 EFX05606.1 - 5.7e-89 297.2 0.0 6.6e-89 297.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 HSP70 PF00012.20 EFX05607.1 - 2.5e-163 544.5 2.7 4e-163 543.8 2.7 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFX05607.1 - 2e-11 43.3 0.0 1.5e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Ketoacyl-synt_C PF02801.22 EFX05607.1 - 0.02 14.9 0.0 0.075 13.0 0.0 2.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain FtsA PF14450.6 EFX05607.1 - 0.3 11.5 5.5 4.1 7.9 0.1 3.7 3 2 0 4 4 4 0 Cell division protein FtsA AAA PF00004.29 EFX05610.1 - 2.3e-09 37.7 0.0 6.8e-09 36.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFX05610.1 - 6.3e-06 26.5 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX05610.1 - 5.8e-05 23.5 0.2 0.00031 21.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFX05610.1 - 0.00011 21.9 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFX05610.1 - 0.00015 21.8 0.0 0.00038 20.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EFX05610.1 - 0.00019 21.6 0.6 0.0046 17.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EFX05610.1 - 0.00051 20.0 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EFX05610.1 - 0.0073 16.1 2.3 0.026 14.2 2.3 1.9 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFX05610.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EFX05610.1 - 0.027 14.5 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFX05610.1 - 0.04 14.2 0.5 0.15 12.4 0.5 2.0 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFX05610.1 - 0.043 13.7 1.4 0.05 13.5 0.1 1.8 2 0 0 2 2 1 0 NTPase Zeta_toxin PF06414.12 EFX05610.1 - 0.075 12.3 0.4 0.17 11.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 EFX05610.1 - 0.083 13.4 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Serglycin PF04360.12 EFX05610.1 - 0.088 12.7 1.7 2 8.4 0.8 3.4 3 0 0 3 3 3 0 Serglycin IstB_IS21 PF01695.17 EFX05610.1 - 0.17 11.6 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EFX05610.1 - 0.18 11.8 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFX05610.1 - 1.3 9.2 0.0 1.3 9.2 0.0 3.3 5 0 0 5 5 4 0 AAA domain MscL PF01741.18 EFX05611.1 - 9.3e-19 67.9 0.1 1.2e-18 67.6 0.1 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.15 EFX05611.1 - 0.0016 18.4 2.5 0.0026 17.7 2.5 1.3 1 0 0 1 1 1 1 BED zinc finger C1_1 PF00130.22 EFX05611.1 - 0.0062 16.4 1.2 0.0091 15.9 1.2 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 EFX05611.1 - 0.13 12.3 0.5 0.19 11.8 0.5 1.2 1 0 0 1 1 1 0 Double zinc ribbon Hexokinase_1 PF00349.21 EFX05612.1 - 1.8e-45 155.3 0.0 2.4e-45 154.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EFX05612.1 - 1.9e-42 145.4 0.0 2.4e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Docking PF08990.11 EFX05614.1 - 0.081 12.6 0.1 0.58 9.8 0.1 2.3 2 0 0 2 2 2 0 Erythronolide synthase docking Peptidase_M3 PF01432.20 EFX05615.1 - 6.5e-150 500.4 0.0 8.9e-150 499.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 AltA1 PF16541.5 EFX05616.1 - 4.3e-16 59.7 0.3 8.1e-16 58.9 0.1 1.5 1 1 1 2 2 2 1 Alternaria alternata allergen 1 Glyco_hydro_3_C PF01915.22 EFX05617.1 - 1.9e-58 197.8 0.0 4e-58 196.7 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EFX05617.1 - 1.2e-44 153.0 0.0 9.2e-44 150.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EFX05617.1 - 4.7e-16 58.7 0.2 1.3e-15 57.2 0.2 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EFX05617.1 - 7.4e-14 51.8 0.0 1.4e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Pkinase PF00069.25 EFX05618.1 - 4.3e-23 82.0 0.1 3.1e-22 79.2 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05618.1 - 3.4e-16 59.3 0.0 1e-15 57.7 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase NACHT PF05729.12 EFX05618.1 - 4.1e-07 30.1 0.0 1.2e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain DcpS PF05652.12 EFX05619.1 - 9.9e-33 113.1 0.0 4.2e-32 111.1 0.0 2.0 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EFX05619.1 - 7e-30 103.8 0.0 1.5e-29 102.8 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding PHP PF02811.19 EFX05619.1 - 2.3e-09 37.8 0.0 5.1e-09 36.6 0.0 1.6 1 1 0 1 1 1 1 PHP domain NMO PF03060.15 EFX05620.1 - 5e-53 180.6 0.1 6.9e-53 180.2 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFX05620.1 - 1.9e-08 33.7 0.0 4e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFX05620.1 - 0.00018 20.6 0.5 0.00028 20.0 0.5 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 EFX05620.1 - 0.062 12.5 0.0 0.22 10.7 0.0 1.9 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Vps53_N PF04100.12 EFX05621.1 - 4.6e-98 328.7 0.0 1.1e-97 327.5 0.0 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal Sec6 PF06046.13 EFX05621.1 - 8.4e-08 31.0 0.0 0.0004 18.9 0.0 2.3 2 0 0 2 2 2 2 Exocyst complex component Sec6 DUF2451 PF10474.9 EFX05621.1 - 5e-05 23.2 0.3 0.0001 22.2 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EFX05621.1 - 5.6e-05 22.6 0.6 9.5e-05 21.8 0.6 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 EFX05621.1 - 0.013 14.1 1.9 0.046 12.3 0.7 2.0 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 VPS53_C PF16854.5 EFX05621.1 - 0.023 14.6 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF5082 PF16888.5 EFX05621.1 - 0.12 12.6 0.1 0.38 11.0 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) COG2 PF06148.11 EFX05621.1 - 4.9 7.3 6.6 6.7 6.8 1.4 3.6 3 2 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DAHP_synth_1 PF00793.20 EFX05622.1 - 1.9e-99 332.0 0.0 2.3e-99 331.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Orn_Arg_deC_N PF02784.16 EFX05622.1 - 0.12 11.7 0.0 0.38 10.1 0.0 1.7 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain p450 PF00067.22 EFX05623.1 - 2.3e-34 118.9 0.0 3.9e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Hydantoinase_B PF02538.14 EFX05624.1 - 2.9e-211 702.4 0.2 3.8e-211 702.0 0.2 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EFX05624.1 - 1.9e-90 303.0 0.0 3.6e-90 302.1 0.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFX05624.1 - 1.1e-54 184.8 0.0 2.1e-53 180.7 0.0 2.3 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region RabGAP-TBC PF00566.18 EFX05625.1 - 6.8e-17 61.8 0.0 8.6e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rho_GDI PF02115.17 EFX05627.1 - 1.3e-59 201.2 0.1 3.6e-59 199.8 0.1 1.6 1 1 0 1 1 1 1 RHO protein GDP dissociation inhibitor UCH_C PF18031.1 EFX05628.1 - 0.046 13.6 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolases Sterol-sensing PF12349.8 EFX05629.1 - 7.6e-31 107.0 9.7 1.3e-30 106.2 8.3 2.1 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EFX05629.1 - 1.4e-06 26.7 3.8 2.2e-06 26.1 3.8 1.2 1 0 0 1 1 1 1 Patched family WD40 PF00400.32 EFX05629.1 - 0.55 11.2 3.8 2.6 9.0 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat PUB_1 PF18486.1 EFX05630.1 - 0.0059 16.4 0.0 0.13 12.1 0.1 2.4 2 0 0 2 2 2 1 PNGase/UBA- or UBX-containing domain PT PF04886.12 EFX05630.1 - 0.57 9.8 7.1 5.6 6.6 4.1 2.3 2 0 0 2 2 2 0 PT repeat TFIIF_alpha PF05793.12 EFX05630.1 - 7.5 5.0 11.9 11 4.5 11.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) OPT PF03169.15 EFX05631.1 - 1.3e-205 684.7 34.0 1.5e-205 684.5 34.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SUIM_assoc PF16619.5 EFX05632.1 - 0.00071 19.6 0.1 0.0025 17.8 0.1 1.9 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Zn_clus PF00172.18 EFX05632.1 - 0.002 18.2 9.8 0.0042 17.2 9.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CBP_BcsF PF11120.8 EFX05632.1 - 0.002 18.2 0.4 0.52 10.5 0.0 2.7 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsF CDC14 PF08045.11 EFX05632.1 - 0.02 14.0 2.1 0.037 13.1 2.1 1.4 1 0 0 1 1 1 0 Cell division control protein 14, SIN component AnfO_nitrog PF09582.10 EFX05632.1 - 0.022 14.1 1.0 0.036 13.4 1.0 1.2 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Med26_M PF15694.5 EFX05632.1 - 0.061 13.4 6.2 0.12 12.4 6.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain Peptidase_U57 PF05582.12 EFX05632.1 - 0.075 12.3 1.3 0.12 11.6 1.3 1.2 1 0 0 1 1 1 0 YabG peptidase U57 AraC_N PF06719.13 EFX05632.1 - 0.097 12.3 2.4 0.42 10.3 0.5 2.4 2 0 0 2 2 2 0 AraC-type transcriptional regulator N-terminus Fungal_trans PF04082.18 EFX05632.1 - 0.17 10.9 0.1 0.34 9.9 0.1 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain UCH_1 PF13423.6 EFX05632.1 - 6.3 6.3 7.4 1.2 8.6 3.3 1.7 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase ADH_N PF08240.12 EFX05633.1 - 4.8e-27 94.0 1.6 1.1e-26 92.9 1.6 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX05633.1 - 4.5e-17 62.2 0.2 1.3e-15 57.5 0.2 2.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX05633.1 - 7.4e-10 38.7 0.1 0.00038 20.0 0.1 2.6 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 EFX05633.1 - 0.0047 16.5 0.3 0.0095 15.5 0.3 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EFX05633.1 - 0.013 14.8 0.8 0.013 14.8 0.8 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 EFX05633.1 - 0.014 14.8 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 ThiF family ADH_zinc_N_2 PF13602.6 EFX05633.1 - 0.023 15.8 0.0 0.047 14.7 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase NADH_4Fe-4S PF10589.9 EFX05633.1 - 0.029 14.4 0.8 0.43 10.7 0.6 2.6 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Shikimate_DH PF01488.20 EFX05633.1 - 0.041 13.9 0.0 0.088 12.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 EFX05633.1 - 0.062 13.4 0.4 0.12 12.5 0.4 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_8 PF13450.6 EFX05633.1 - 0.063 13.5 1.6 0.43 10.9 0.7 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 EFX05633.1 - 0.074 12.9 0.4 0.12 12.2 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFX05633.1 - 0.18 11.2 0.1 0.3 10.4 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ifi-6-16 PF06140.13 EFX05635.1 - 7.7e-08 32.2 25.8 1.3e-07 31.4 25.8 1.4 1 0 0 1 1 1 1 Interferon-induced 6-16 family FAM176 PF14851.6 EFX05635.1 - 0.0054 16.4 4.2 1.4 8.5 2.4 2.1 2 0 0 2 2 2 2 FAM176 family NOA36 PF06524.12 EFX05635.1 - 0.045 13.1 1.3 0.055 12.8 1.3 1.1 1 0 0 1 1 1 0 NOA36 protein CPSF100_C PF13299.6 EFX05635.1 - 0.051 13.8 0.1 0.071 13.3 0.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BCLP PF12304.8 EFX05635.1 - 0.074 12.6 0.2 0.11 12.0 0.2 1.3 1 0 0 1 1 1 0 Beta-casein like protein Hydantoinase_B PF02538.14 EFX05636.1 - 1.6e-211 703.2 0.5 2.1e-211 702.8 0.5 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EFX05636.1 - 3.3e-99 331.8 0.0 1.4e-98 329.7 0.0 1.9 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFX05636.1 - 2e-59 200.3 0.6 2.5e-57 193.5 0.0 2.4 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region DNA_binding_1 PF01035.20 EFX05637.1 - 4e-30 103.8 0.3 9.4e-30 102.6 0.3 1.6 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain MFS_1 PF07690.16 EFX05638.1 - 9.3e-32 110.3 24.9 1.2e-31 109.9 24.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily T2SSE_N PF05157.15 EFX05639.1 - 0.042 14.1 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein E, N-terminal domain SQS_PSY PF00494.19 EFX05640.1 - 0.0035 16.9 0.0 0.0039 16.7 0.0 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF1275 PF06912.11 EFX05641.1 - 1.4e-36 126.3 16.0 2.5e-36 125.4 16.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) DEAD PF00270.29 EFX05641.1 - 3.9e-20 72.4 0.0 1.5e-19 70.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EFX05641.1 - 9.2e-20 71.1 5.0 2.9e-19 69.5 5.0 2.0 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.31 EFX05641.1 - 6.5e-19 68.3 0.0 4.8e-16 59.1 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RQC PF09382.10 EFX05641.1 - 1e-09 38.2 0.1 2.1e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 EFX05641.1 - 2.5e-05 24.2 0.0 6e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 EFX05641.1 - 0.00011 22.3 0.0 0.00025 21.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RSN1_7TM PF02714.15 EFX05642.1 - 1.2e-89 300.3 20.4 1.2e-89 300.3 20.4 1.9 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFX05642.1 - 4.3e-44 150.0 3.6 4.3e-44 150.0 3.6 3.6 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFX05642.1 - 1.2e-35 123.3 0.1 1.9e-35 122.6 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EFX05642.1 - 4.9e-31 106.7 0.2 1.7e-30 105.1 0.1 1.9 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter DUF1330 PF07045.11 EFX05642.1 - 0.038 14.3 0.0 0.094 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) NAD_binding_1 PF00175.21 EFX05644.1 - 5.7e-18 65.5 0.0 9e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFX05644.1 - 4.5e-10 39.8 0.0 8.7e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFX05644.1 - 0.0032 17.6 0.0 0.0065 16.6 0.0 1.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Aldo_ket_red PF00248.21 EFX05645.1 - 7.3e-38 130.4 0.0 9.2e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family TauD PF02668.16 EFX05647.1 - 1.8e-33 116.5 0.0 2.6e-33 116.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family LssY_C PF14067.6 EFX05647.1 - 0.039 13.5 0.1 0.41 10.2 0.0 2.3 3 0 0 3 3 3 0 LssY C-terminus O-FucT PF10250.9 EFX05648.1 - 1e-05 25.4 0.0 2.1e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF4478 PF14793.6 EFX05648.1 - 0.18 11.7 0.0 0.47 10.3 0.0 1.6 1 1 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases Cutinase PF01083.22 EFX05649.1 - 1.1e-38 133.0 0.6 1.3e-38 132.7 0.6 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EFX05649.1 - 0.00041 20.0 0.1 0.00059 19.4 0.1 1.3 1 0 0 1 1 1 1 PE-PPE domain DUF2974 PF11187.8 EFX05649.1 - 0.013 15.1 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 EFX05649.1 - 0.017 15.8 0.1 0.019 15.6 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DLH PF01738.18 EFX05649.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family ALG3 PF05208.13 EFX05650.1 - 4.5e-147 490.2 7.3 5.4e-147 489.9 7.3 1.0 1 0 0 1 1 1 1 ALG3 protein Fungal_trans PF04082.18 EFX05651.1 - 4.5e-08 32.5 0.1 7.2e-08 31.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pro_isomerase PF00160.21 EFX05652.1 - 1.3e-49 168.5 0.1 1.5e-49 168.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ferric_reduct PF01794.19 EFX05653.1 - 3.9e-24 85.1 5.7 1.3e-23 83.5 5.8 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFX05653.1 - 3.8e-20 72.6 0.0 2.7e-17 63.3 0.0 2.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFX05653.1 - 8.7e-15 54.8 0.0 2.8e-13 49.9 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain CPSF73-100_C PF11718.8 EFX05655.1 - 1.2e-84 283.2 0.1 1.8e-84 282.6 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EFX05655.1 - 1e-29 103.0 0.0 2.2e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EFX05655.1 - 1.3e-18 67.7 0.8 3.1e-18 66.5 0.8 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EFX05655.1 - 9.5e-18 64.3 0.1 1.7e-17 63.5 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EFX05655.1 - 5.7e-13 48.6 0.0 1.2e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 EFX05655.1 - 1.6e-06 28.1 0.1 3.8e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EFX05655.1 - 2.9e-05 23.7 0.5 6.9e-05 22.4 0.5 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EFX05655.1 - 0.055 12.7 0.0 0.093 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative beta-lactamase-like family RNA_pol_Rpc4 PF05132.14 EFX05655.1 - 0.85 10.0 3.0 0.31 11.5 0.2 1.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 MEA1 PF06910.11 EFX05655.1 - 1.3 9.7 0.0 1.3 9.7 0.0 3.0 3 0 0 3 3 3 0 Male enhanced antigen 1 (MEA1) DUF4746 PF15928.5 EFX05655.1 - 4.7 6.5 8.6 10 5.4 4.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) MMU163 PF17119.5 EFX05656.1 - 7e-85 284.1 5.4 1.9e-82 276.2 5.4 2.0 1 1 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis Tom5 PF10642.9 EFX05656.1 - 0.14 12.2 0.3 0.33 11.0 0.3 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase tRNA-synt_1d PF00750.19 EFX05657.1 - 2.2e-24 86.1 0.2 3e-24 85.6 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFX05657.1 - 1.4e-14 54.3 0.1 2.6e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain TcdA_TcdB PF12919.7 EFX05657.1 - 0.064 12.5 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain N-SET PF11764.8 EFX05658.1 - 3.4e-56 190.1 0.2 3.4e-56 190.1 0.2 3.3 4 0 0 4 4 4 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EFX05658.1 - 5e-25 86.9 0.9 1.8e-24 85.2 0.9 2.0 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 EFX05658.1 - 3.1e-19 70.0 0.0 3.1e-19 70.0 0.0 4.4 2 2 1 3 3 3 1 SET domain CorA PF01544.18 EFX05660.1 - 1.9e-08 34.0 0.2 2.9e-08 33.4 0.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PH_6 PF15406.6 EFX05661.1 - 1.4e-46 157.3 3.6 1.4e-46 157.3 3.6 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EFX05661.1 - 0.00011 22.6 0.1 0.00032 21.2 0.1 1.9 1 1 0 1 1 1 1 PH domain PH_4 PF15404.6 EFX05661.1 - 0.0086 15.9 0.0 0.0086 15.9 0.0 2.4 3 0 0 3 3 3 1 Pleckstrin homology domain PH_13 PF16652.5 EFX05661.1 - 0.017 15.0 1.7 0.018 14.8 0.2 1.8 1 1 1 2 2 2 0 Pleckstrin homology domain NCD2 PF04905.13 EFX05661.1 - 0.33 10.9 2.1 5.7 6.9 0.1 2.7 2 0 0 2 2 2 0 NAB conserved region 2 (NCD2) Peptidase_M20 PF01546.28 EFX05662.1 - 2.6e-30 105.7 0.0 5e-30 104.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX05662.1 - 7.7e-13 48.3 0.1 2.9e-12 46.4 0.0 2.1 2 1 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFX05662.1 - 0.055 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 5-FTHF_cyc-lig PF01812.20 EFX05663.1 - 9.3e-31 107.1 0.0 1.5e-30 106.4 0.0 1.3 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family OPT PF03169.15 EFX05664.1 - 5.2e-129 431.7 47.5 6e-129 431.5 47.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein HET PF06985.11 EFX05665.1 - 1.6e-18 67.5 0.0 5.9e-18 65.6 0.0 2.0 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) IBR PF01485.21 EFX05666.1 - 5.7e-13 48.9 3.8 5.7e-13 48.9 3.8 3.8 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zinc_ribbon_2 PF13240.6 EFX05666.1 - 0.073 12.8 0.2 0.073 12.8 0.2 4.0 5 0 0 5 5 5 0 zinc-ribbon domain DUF4927 PF16279.5 EFX05666.1 - 0.14 13.2 0.9 3.6 8.7 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4927) Zn-ribbon_8 PF09723.10 EFX05666.1 - 0.27 11.4 0.3 0.27 11.4 0.3 4.7 3 2 2 5 5 5 0 Zinc ribbon domain zf_UBZ PF18439.1 EFX05666.1 - 2.5 7.8 14.5 1.1 8.9 0.2 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-ribbon_3 PF13248.6 EFX05666.1 - 3.3 7.2 20.9 0.21 11.0 0.6 4.3 4 0 0 4 4 4 0 zinc-ribbon domain Sugar_tr PF00083.24 EFX05667.1 - 1.8e-70 238.0 25.5 2.1e-70 237.8 25.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05667.1 - 2.9e-14 52.8 30.4 2.7e-12 46.3 25.4 2.9 1 1 1 3 3 3 3 Major Facilitator Superfamily 4HBT PF03061.22 EFX05669.1 - 5.1e-09 36.4 0.2 3.1e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 Thioesterase superfamily Pex14_N PF04695.13 EFX05669.1 - 0.0095 16.6 0.6 0.016 15.9 0.6 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CAP_N PF01213.19 EFX05669.1 - 0.88 9.0 4.4 1.5 8.3 4.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FAD_binding_3 PF01494.19 EFX05670.1 - 1.5e-65 221.8 0.0 1.9e-65 221.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFX05670.1 - 0.0014 19.2 0.0 0.26 11.9 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFX05670.1 - 0.0062 15.8 0.0 0.62 9.2 0.0 3.4 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFX05670.1 - 0.08 11.6 0.1 1.4 7.5 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 EFX05670.1 - 0.13 12.5 0.1 0.4 11.0 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RPAP2_Rtr1 PF04181.13 EFX05673.1 - 2.2e-20 72.7 0.0 4e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family YnfE PF17452.2 EFX05674.1 - 0.11 12.8 0.9 0.16 12.3 0.9 1.4 1 1 0 1 1 1 0 Uncharacterized YnfE-like Egh16-like PF11327.8 EFX05675.1 - 4.4e-13 50.0 4.5 4.4e-13 50.0 4.5 1.9 1 1 1 2 2 2 1 Egh16-like virulence factor Kelch_5 PF13854.6 EFX05676.1 - 4.1e-41 138.4 6.7 6.2e-07 29.3 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EFX05676.1 - 2.5e-39 132.6 12.3 7.1e-09 35.1 1.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFX05676.1 - 1.2e-35 120.6 9.3 9.7e-07 28.9 0.1 6.7 4 2 2 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFX05676.1 - 7.2e-35 118.8 14.9 1.1e-08 34.9 0.3 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EFX05676.1 - 1.3e-33 114.6 22.8 3.8e-08 33.4 0.1 8.0 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFX05676.1 - 4.9e-30 102.3 8.0 2.9e-06 27.0 0.3 6.6 6 0 0 6 6 6 6 Kelch motif FAM27 PF15832.5 EFX05676.1 - 1.3 9.7 10.5 0.18 12.3 2.8 3.0 3 0 0 3 3 3 0 FAM27 D and E protein family Prefoldin_2 PF01920.20 EFX05677.1 - 2.2e-19 69.3 0.8 2.8e-19 69.0 0.8 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF2205 PF10224.9 EFX05677.1 - 0.0039 17.2 0.9 0.0054 16.7 0.9 1.2 1 0 0 1 1 1 1 Short coiled-coil protein SAS-6_N PF16531.5 EFX05677.1 - 0.016 15.8 0.1 0.019 15.5 0.1 1.1 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal EAP30 PF04157.16 EFX05677.1 - 0.018 14.3 0.2 0.018 14.3 0.2 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family SLATT_1 PF18181.1 EFX05677.1 - 0.038 13.9 0.5 0.046 13.6 0.5 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Retrotran_gag_2 PF14223.6 EFX05677.1 - 0.063 13.0 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF2089 PF09862.9 EFX05677.1 - 0.081 13.0 0.0 0.084 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) Chi-conotoxin PF16981.5 EFX05677.1 - 0.22 11.8 0.3 0.43 10.9 0.3 1.5 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily DUF2205 PF10224.9 EFX05678.1 - 0.015 15.2 1.0 0.035 14.1 1.0 1.5 1 0 0 1 1 1 0 Short coiled-coil protein TACC_C PF05010.14 EFX05678.1 - 0.055 13.3 0.2 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF842 PF05811.13 EFX05678.1 - 0.18 11.5 0.8 0.38 10.5 0.8 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) KTI12 PF08433.10 EFX05679.1 - 1.3e-64 218.3 0.0 2.2e-64 217.5 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EFX05679.1 - 0.00011 22.4 0.0 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFX05679.1 - 0.11 13.1 0.0 0.4 11.2 0.0 2.2 1 1 0 1 1 1 0 AAA domain Cpn60_TCP1 PF00118.24 EFX05680.1 - 7.3e-150 499.8 12.0 8.3e-150 499.6 12.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mei5 PF10376.9 EFX05680.1 - 0.053 13.4 0.3 0.16 11.8 0.2 1.8 2 0 0 2 2 2 0 Double-strand recombination repair protein Amidohydro_1 PF01979.20 EFX05681.1 - 1e-26 94.1 0.1 2e-17 63.5 0.1 2.2 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 EFX05681.1 - 6.8e-13 48.9 0.1 1.4e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family Myb_DNA-bind_6 PF13921.6 EFX05682.1 - 4.3e-13 49.3 1.0 7.6e-08 32.5 0.7 3.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFX05682.1 - 4.6e-12 45.9 16.3 2.4e-07 30.8 3.3 4.0 5 1 0 5 5 5 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFX05682.1 - 7.7e-05 23.0 4.0 0.0025 18.1 0.2 3.0 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EFX05682.1 - 1.1 9.6 0.0 1.1 9.6 0.0 5.3 5 2 2 7 7 7 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Pkinase PF00069.25 EFX05683.1 - 4.6e-61 206.5 0.1 1.8e-60 204.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05683.1 - 1.6e-35 122.7 0.0 2.7e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EFX05683.1 - 2.4e-23 82.0 18.3 5.5e-13 48.8 5.2 2.6 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EFX05683.1 - 6.9e-21 73.9 27.5 6.2e-13 48.4 8.5 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EFX05683.1 - 1e-14 54.9 1.5 4.6e-14 52.8 1.5 2.3 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EFX05683.1 - 0.043 13.1 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EFX05683.1 - 0.071 12.0 0.0 0.14 11.0 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain zf-RING_9 PF13901.6 EFX05683.1 - 5.6 6.9 20.2 3 7.8 6.2 2.6 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon NUDIX PF00293.28 EFX05685.1 - 4.4e-10 39.7 0.0 9.8e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain F-box-like PF12937.7 EFX05685.1 - 1.3e-05 25.0 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like Ribosomal_L6 PF00347.23 EFX05686.1 - 1.1e-21 77.3 0.0 3.3e-10 40.5 0.0 2.5 2 0 0 2 2 2 2 Ribosomal protein L6 DUF87 PF01935.17 EFX05687.1 - 6.4e-05 23.2 0.1 0.0012 19.0 0.1 2.2 1 1 0 1 1 1 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EFX05687.1 - 0.008 15.6 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF853 PF05872.12 EFX05687.1 - 0.058 12.0 0.0 0.26 9.9 0.0 2.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) AAA_16 PF13191.6 EFX05687.1 - 0.062 13.7 0.0 1.6 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EFX05687.1 - 0.085 13.1 0.0 4.3 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFX05687.1 - 0.087 12.1 0.0 0.24 10.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 EFX05687.1 - 0.14 12.0 0.4 5.5 6.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Fungal_trans PF04082.18 EFX05688.1 - 7.4e-24 84.2 0.1 2.6e-23 82.4 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05688.1 - 2.2e-09 37.3 11.6 3.8e-09 36.5 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sad1_UNC PF07738.13 EFX05689.1 - 5e-09 36.3 0.0 2.5e-07 30.8 0.0 2.4 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Trypan_PARP PF05887.11 EFX05689.1 - 0.9 9.5 30.6 0.054 13.5 16.4 2.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Nexin_C PF08628.12 EFX05689.1 - 6.3 7.4 12.6 0.16 12.5 4.0 2.4 2 0 0 2 2 2 0 Sorting nexin C terminal Macoilin PF09726.9 EFX05691.1 - 0.36 9.3 11.3 0.46 9.0 11.3 1.1 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 EFX05691.1 - 0.53 9.2 8.4 0.67 8.9 8.4 1.1 1 0 0 1 1 1 0 Mitoguardin SPX PF03105.19 EFX05691.1 - 1.1 9.1 9.2 1.4 8.8 9.2 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 EFX05691.1 - 2.3 7.0 9.5 2.6 6.8 9.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pet127 PF08634.10 EFX05692.1 - 1.5e-116 388.7 3.6 1.5e-116 388.7 3.6 2.1 2 0 0 2 2 2 1 Mitochondrial protein Pet127 DUF4448 PF14610.6 EFX05693.1 - 2.4e-37 128.6 0.2 4.1e-37 127.8 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) SKG6 PF08693.10 EFX05693.1 - 3.7 7.1 7.9 0.12 11.8 0.6 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Rad60-SLD PF11976.8 EFX05694.1 - 2.2e-19 69.1 0.2 2.6e-19 68.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFX05694.1 - 3.2e-11 42.8 0.2 3.7e-11 42.6 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin family UPF0121 PF03661.13 EFX05695.1 - 3.4e-31 108.5 7.6 4.6e-31 108.1 7.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) T_cell_tran_alt PF15128.6 EFX05695.1 - 2.7 7.9 5.7 0.55 10.1 0.3 2.6 3 0 0 3 3 3 0 T-cell leukemia translocation-altered Abhydrolase_6 PF12697.7 EFX05696.1 - 2e-19 71.1 11.1 2.1e-19 71.0 8.2 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX05696.1 - 1.1e-06 28.5 0.7 0.043 13.5 0.1 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX05696.1 - 0.0028 17.0 0.0 0.005 16.1 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EFX05696.1 - 0.2 11.4 0.0 0.47 10.2 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sulfatase PF00884.23 EFX05697.1 - 2.6e-46 158.4 0.2 1.9e-43 149.1 0.1 3.0 2 1 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 EFX05697.1 - 6.1e-07 29.3 0.2 1.6e-05 24.7 0.0 2.5 2 2 1 3 3 3 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EFX05697.1 - 0.00012 22.3 0.1 0.00036 20.7 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Sulfatase_C PF14707.6 EFX05697.1 - 0.0011 19.7 0.0 0.0024 18.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 EFX05697.1 - 0.0064 15.6 0.0 0.02 14.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1501) GDP_Man_Dehyd PF16363.5 EFX05698.1 - 4.3e-47 161.1 0.0 9.2e-47 160.0 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFX05698.1 - 1.1e-46 159.3 0.0 1.3e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX05698.1 - 3.4e-15 55.8 0.0 1.9e-14 53.4 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFX05698.1 - 8.3e-14 51.4 0.1 5.6e-12 45.4 0.1 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFX05698.1 - 1.6e-13 50.4 0.0 2.3e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EFX05698.1 - 5.5e-09 35.8 0.1 8.6e-09 35.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EFX05698.1 - 1.2e-07 31.2 0.0 1.4e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 EFX05698.1 - 5.6e-06 26.4 0.0 1.1e-05 25.5 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFX05698.1 - 0.00075 19.4 0.0 0.0023 17.9 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding adh_short_C2 PF13561.6 EFX05698.1 - 0.0014 18.3 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 EFX05698.1 - 0.0069 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Thrombin_light PF09396.10 EFX05698.1 - 0.071 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Thrombin light chain UDPG_MGDP_dh_N PF03721.14 EFX05698.1 - 0.16 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Fungal_trans_2 PF11951.8 EFX05699.1 - 3.7e-29 101.7 0.1 6.2e-11 41.7 0.1 3.1 2 1 1 3 3 3 3 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05699.1 - 5.3e-09 36.1 11.6 8.7e-09 35.4 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Orthopox_A49R PF06489.11 EFX05699.1 - 0.039 14.2 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus A49R protein AT_hook PF02178.19 EFX05699.1 - 0.78 9.8 6.5 2.4 8.3 6.5 1.8 1 0 0 1 1 1 0 AT hook motif Tim17 PF02466.19 EFX05700.1 - 1e-31 109.6 8.0 1.3e-31 109.2 8.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family IBN_N PF03810.19 EFX05701.1 - 3.4e-09 36.5 0.0 3.1e-08 33.4 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFX05701.1 - 0.0054 16.8 0.2 0.54 10.3 0.0 4.1 5 1 0 5 5 5 1 Exportin 1-like protein DUF5301 PF17225.3 EFX05703.1 - 0.16 12.4 2.6 0.25 11.8 1.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5300) XRN_M PF17846.1 EFX05703.1 - 1.5 7.7 6.3 2 7.3 6.3 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DUF5093 PF17011.5 EFX05703.1 - 4.2 7.7 8.5 0.49 10.7 4.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) WD40 PF00400.32 EFX05704.1 - 5.3e-13 49.2 11.8 4e-06 27.5 0.0 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat SLAC1 PF03595.17 EFX05705.1 - 1.1e-79 268.1 50.0 1.3e-79 267.8 50.0 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Cu_amine_oxid PF01179.20 EFX05707.1 - 8.8e-129 430.0 4.7 1.1e-128 429.7 4.7 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EFX05707.1 - 3.4e-35 119.6 0.5 8.3e-35 118.4 0.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 EFX05707.1 - 0.009 16.2 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain NifU_N PF01592.16 EFX05709.1 - 2.5e-52 176.4 0.0 2.5e-52 176.4 0.0 1.5 2 0 0 2 2 2 1 NifU-like N terminal domain Methyltransf_15 PF09445.10 EFX05711.1 - 7.8e-40 136.2 0.0 1.1e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EFX05711.1 - 0.00019 21.2 0.0 0.00028 20.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_5 PF01795.19 EFX05711.1 - 0.0061 16.1 0.0 0.0081 15.7 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltransf_25 PF13649.6 EFX05711.1 - 0.0085 16.8 0.0 0.016 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CDC45 PF02724.14 EFX05711.1 - 0.015 13.6 13.3 0.019 13.3 13.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Cons_hypoth95 PF03602.15 EFX05711.1 - 0.039 13.6 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MID_MedPIWI PF18296.1 EFX05711.1 - 0.065 13.0 1.3 0.084 12.6 1.3 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Methyltransf_11 PF08241.12 EFX05711.1 - 0.16 12.7 0.0 0.28 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Herpes_capsid PF06112.11 EFX05711.1 - 0.18 11.8 6.7 0.28 11.3 6.7 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SID-1_RNA_chan PF13965.6 EFX05711.1 - 0.45 8.9 1.8 0.56 8.6 1.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RNA_polI_A34 PF08208.11 EFX05711.1 - 0.95 9.5 13.2 1.3 9.0 13.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 PPL5 PF18168.1 EFX05711.1 - 1.3 8.3 8.1 1.8 7.8 8.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 RNA_pol_3_Rpc31 PF11705.8 EFX05711.1 - 1.5 9.0 26.7 2.5 8.3 26.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.10 EFX05711.1 - 2.3 8.9 26.3 4.5 8.0 26.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) NPR3 PF03666.13 EFX05711.1 - 2.5 6.8 16.1 3.4 6.3 16.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Smg8_Smg9 PF10220.9 EFX05711.1 - 2.8 6.1 9.2 3.3 5.9 9.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF913 PF06025.12 EFX05711.1 - 2.9 6.8 11.2 4.1 6.3 11.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NOA36 PF06524.12 EFX05711.1 - 3.1 7.0 26.9 5.1 6.3 26.9 1.3 1 0 0 1 1 1 0 NOA36 protein FGF-BP1 PF06473.12 EFX05711.1 - 4.2 7.1 7.6 6.9 6.4 7.6 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) GEMIN8 PF15348.6 EFX05711.1 - 5.5 7.2 16.1 9.1 6.5 16.1 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Aminotran_1_2 PF00155.21 EFX05713.1 - 1.1e-35 123.5 0.0 1.4e-35 123.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFX05713.1 - 3.8e-05 23.1 0.0 6.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EFX05713.1 - 8.2e-05 21.3 0.0 0.00013 20.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFX05713.1 - 0.00011 21.4 0.0 0.00016 20.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V EMP70 PF02990.16 EFX05714.1 - 2.7e-206 686.3 7.2 2.7e-206 686.3 7.2 1.3 2 0 0 2 2 2 1 Endomembrane protein 70 DUF1282 PF06930.12 EFX05715.1 - 0.0071 16.1 1.2 0.011 15.5 1.2 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1282) TMEM154 PF15102.6 EFX05716.1 - 0.04 13.8 0.2 0.08 12.8 0.2 1.5 1 0 0 1 1 1 0 TMEM154 protein family PTP_tm PF18861.1 EFX05716.1 - 0.071 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Macoilin PF09726.9 EFX05716.1 - 2.4 6.6 4.4 3.3 6.1 4.4 1.1 1 0 0 1 1 1 0 Macoilin family PI-PLC-C1 PF16670.5 EFX05717.1 - 0.22 10.6 0.0 0.35 9.9 0.0 1.3 2 0 0 2 2 2 0 Phosphoinositide phospholipase C, Ca2+-dependent Ras PF00071.22 EFX05718.1 - 7.6e-57 191.4 0.1 1.2e-56 190.8 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX05718.1 - 2e-30 105.5 0.0 3.5e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase EamA PF00892.20 EFX05718.1 - 1.6e-12 47.8 33.3 2.1e-07 31.2 4.4 3.2 3 0 0 3 3 3 2 EamA-like transporter family Arf PF00025.21 EFX05718.1 - 2.5e-12 46.6 0.0 3.7e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF3955 PF13127.6 EFX05718.1 - 4.4e-10 39.2 0.8 2.2e-09 37.0 0.8 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3955) MMR_HSR1 PF01926.23 EFX05718.1 - 2.2e-07 30.9 0.0 4e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFX05718.1 - 1.3e-05 24.6 0.0 3e-05 23.5 0.0 1.6 2 0 0 2 2 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFX05718.1 - 0.00021 21.2 0.0 0.023 14.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFX05718.1 - 0.00027 20.5 0.1 0.0033 17.0 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SLC35F PF06027.12 EFX05718.1 - 0.00038 20.1 8.1 0.00038 20.1 8.1 1.8 2 1 0 2 2 2 1 Solute carrier family 35 UAA PF08449.11 EFX05718.1 - 0.00083 18.7 8.5 0.00083 18.7 8.5 1.6 2 0 0 2 2 2 1 UAA transporter family PUNUT PF16913.5 EFX05718.1 - 0.0043 16.3 1.2 0.0043 16.3 1.2 2.2 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport SRPRB PF09439.10 EFX05718.1 - 0.016 14.6 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EFX05718.1 - 0.029 14.7 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain CRT-like PF08627.10 EFX05718.1 - 0.035 13.1 1.5 0.095 11.6 0.1 2.2 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like AAA_24 PF13479.6 EFX05718.1 - 0.056 13.2 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFX05718.1 - 0.077 12.2 0.2 2 7.5 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 EFX05718.1 - 0.091 13.1 0.0 0.23 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EFX05718.1 - 0.1 12.3 0.1 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EFX05718.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Septin CoA_binding_3 PF13727.6 EFX05718.1 - 0.18 11.8 0.0 0.18 11.8 0.0 2.7 4 0 0 4 4 2 0 CoA-binding domain AAA_7 PF12775.7 EFX05718.1 - 0.19 11.2 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TPT PF03151.16 EFX05718.1 - 0.46 9.8 8.9 0.37 10.1 1.5 2.2 2 0 0 2 2 2 0 Triose-phosphate Transporter family DUF1772 PF08592.11 EFX05718.1 - 2.6 8.4 0.0 2.6 8.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1772) AAA_5 PF07728.14 EFX05719.1 - 1e-132 436.9 0.2 5.2e-22 78.3 0.0 9.8 10 0 0 10 10 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EFX05719.1 - 2.2e-37 127.5 3.8 4.6e-11 42.9 0.2 5.9 5 0 0 5 5 5 3 Midasin AAA lid domain AAA PF00004.29 EFX05719.1 - 3e-29 102.1 0.0 0.00016 22.1 0.0 7.0 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX05719.1 - 7e-29 101.4 39.2 2.9e-06 27.8 0.3 10.5 9 2 1 10 10 9 6 AAA ATPase domain AAA_lid_5 PF17865.1 EFX05719.1 - 1.6e-28 98.8 0.1 1.9e-27 95.4 0.0 2.9 3 0 0 3 3 2 1 Midasin AAA lid domain AAA_7 PF12775.7 EFX05719.1 - 1.3e-26 93.2 0.1 0.00028 20.4 0.0 6.9 7 0 0 7 7 7 5 P-loop containing dynein motor region AAA_3 PF07726.11 EFX05719.1 - 5.7e-26 90.9 0.1 6.3e-10 39.0 0.0 7.4 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 EFX05719.1 - 6.5e-26 90.8 0.0 1.9e-05 24.8 0.0 7.1 7 0 0 7 7 6 5 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 EFX05719.1 - 1.7e-22 80.1 0.1 0.00061 20.1 0.0 8.1 7 0 0 7 7 7 4 AAA domain AAA_6 PF12774.7 EFX05719.1 - 1.3e-21 76.9 0.0 0.012 14.6 0.0 9.4 9 0 0 9 9 9 4 Hydrolytic ATP binding site of dynein motor region AAA_33 PF13671.6 EFX05719.1 - 1.5e-18 67.4 0.4 0.048 13.8 0.0 7.6 7 0 0 7 7 6 4 AAA domain TsaE PF02367.17 EFX05719.1 - 8.9e-18 64.5 4.5 0.0018 18.3 0.1 6.6 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EFX05719.1 - 1.8e-17 63.5 0.0 0.075 12.7 0.0 6.8 7 0 0 7 7 6 4 Sigma-54 interaction domain AAA_18 PF13238.6 EFX05719.1 - 5.2e-17 62.6 0.3 0.032 14.8 0.0 7.5 7 0 0 7 7 6 3 AAA domain NACHT PF05729.12 EFX05719.1 - 8.2e-15 55.1 9.8 0.095 12.6 0.3 7.1 5 1 0 5 5 5 5 NACHT domain AAA_14 PF13173.6 EFX05719.1 - 1.5e-13 50.9 0.0 0.13 12.3 0.0 7.2 7 0 0 7 7 6 2 AAA domain ABC_tran PF00005.27 EFX05719.1 - 6.5e-13 49.4 6.9 0.09 13.3 0.0 6.9 7 0 0 7 7 6 3 ABC transporter RsgA_GTPase PF03193.16 EFX05719.1 - 3.1e-12 46.7 2.4 0.056 13.3 0.1 6.3 7 0 0 7 7 6 1 RsgA GTPase Sigma54_activ_2 PF14532.6 EFX05719.1 - 3.6e-12 46.6 1.7 0.0014 18.7 0.0 6.6 7 0 0 7 7 6 2 Sigma-54 interaction domain RNA_helicase PF00910.22 EFX05719.1 - 6.5e-12 45.8 0.1 1.1 9.7 0.0 6.2 6 0 0 6 6 6 2 RNA helicase AAA_28 PF13521.6 EFX05719.1 - 1e-11 45.4 0.5 1.4 9.2 0.0 8.0 8 0 0 8 8 7 1 AAA domain AAA_29 PF13555.6 EFX05719.1 - 3.7e-10 39.4 0.8 2.2 8.1 0.0 6.8 7 0 0 7 7 6 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EFX05719.1 - 1e-09 38.1 7.1 2.1 7.7 0.0 9.0 9 1 0 9 9 9 2 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EFX05719.1 - 1e-09 37.9 2.7 0.081 12.0 0.1 6.2 7 0 0 7 7 6 2 Type II/IV secretion system protein Rad17 PF03215.15 EFX05719.1 - 1.1e-09 38.5 2.7 0.79 9.6 0.0 6.1 6 0 0 6 6 6 2 Rad17 P-loop domain AAA_25 PF13481.6 EFX05719.1 - 1.9e-09 37.4 7.1 0.13 11.8 0.0 6.3 6 0 0 6 6 5 2 AAA domain RuvB_N PF05496.12 EFX05719.1 - 2e-09 37.4 6.5 0.19 11.5 0.0 6.7 8 0 0 8 8 6 2 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EFX05719.1 - 2.3e-09 37.2 0.7 0.73 9.5 0.0 6.3 6 0 0 6 6 6 1 IstB-like ATP binding protein AAA_24 PF13479.6 EFX05719.1 - 1.4e-08 34.7 0.0 1.8 8.3 0.0 6.0 6 0 0 6 6 5 1 AAA domain DUF815 PF05673.13 EFX05719.1 - 5.3e-08 32.3 0.9 3.9 6.5 0.0 5.5 6 0 0 6 6 5 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 EFX05719.1 - 1.2e-07 32.1 4.1 3.4 8.0 0.1 6.3 6 0 0 6 6 5 0 AAA domain PduV-EutP PF10662.9 EFX05719.1 - 2.1e-07 30.8 1.1 0.12 12.1 0.0 5.3 6 0 0 6 6 5 1 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 EFX05719.1 - 3.8e-06 26.3 8.5 3.3 7.0 0.1 6.7 7 0 0 7 7 6 1 Zeta toxin NTPase_1 PF03266.15 EFX05719.1 - 4e-06 26.8 3.3 2.7 7.9 0.0 5.5 5 0 0 5 5 5 1 NTPase SRP54 PF00448.22 EFX05719.1 - 5e-06 26.3 2.8 0.44 10.1 0.1 4.9 6 0 0 6 6 4 1 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 EFX05719.1 - 5.5e-06 26.5 0.0 0.24 11.3 0.0 5.3 5 0 0 5 5 5 1 ATPase domain predominantly from Archaea TniB PF05621.11 EFX05719.1 - 6.1e-06 25.8 0.0 1.8 8.0 0.0 5.8 7 0 0 7 7 5 1 Bacterial TniB protein Roc PF08477.13 EFX05719.1 - 1.8e-05 25.0 0.4 17 5.7 0.1 6.0 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase TIP49 PF06068.13 EFX05719.1 - 8.3e-05 21.9 1.2 0.17 11.0 0.0 4.6 5 0 0 5 5 5 1 TIP49 P-loop domain NB-ARC PF00931.22 EFX05719.1 - 8.8e-05 21.8 0.0 17 4.5 0.0 5.2 5 0 0 5 5 5 0 NB-ARC domain CbiA PF01656.23 EFX05719.1 - 9.2e-05 22.5 0.0 3.8 7.6 0.0 5.0 5 1 0 5 5 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 EFX05719.1 - 0.00021 21.4 0.4 31 4.7 0.0 5.8 6 0 0 6 6 5 0 50S ribosome-binding GTPase dNK PF01712.19 EFX05719.1 - 0.00027 20.8 0.7 4.5 7.1 0.0 4.9 5 0 0 5 5 5 0 Deoxynucleoside kinase ATP_bind_1 PF03029.17 EFX05719.1 - 0.00049 20.0 2.5 14 5.4 0.0 5.0 5 0 0 5 5 4 0 Conserved hypothetical ATP binding protein ResIII PF04851.15 EFX05719.1 - 0.00083 19.4 0.1 5.9 6.9 0.0 4.7 5 0 0 5 5 5 0 Type III restriction enzyme, res subunit DAP3 PF10236.9 EFX05719.1 - 0.0013 18.0 3.9 5.7 6.0 0.0 5.0 6 0 0 6 6 5 0 Mitochondrial ribosomal death-associated protein 3 DEAD PF00270.29 EFX05719.1 - 0.039 13.7 0.3 39 3.9 0.0 4.2 4 0 0 4 4 4 0 DEAD/DEAH box helicase AAA_21 PF13304.6 EFX05719.1 - 0.044 13.6 0.0 20 4.9 0.0 4.2 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Cytidylate_kin PF02224.18 EFX05719.1 - 0.11 12.3 1.9 11 5.7 0.0 4.4 5 0 0 5 5 5 0 Cytidylate kinase MeaB PF03308.16 EFX05719.1 - 0.13 11.2 1.3 4.4 6.2 0.2 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Septin PF00735.18 EFX05719.1 - 0.14 11.4 0.2 12 5.1 0.0 3.6 5 0 0 5 5 4 0 Septin ATPase PF06745.13 EFX05719.1 - 0.15 11.4 0.1 39 3.5 0.0 3.9 4 0 0 4 4 4 0 KaiC SKI PF01202.22 EFX05719.1 - 0.2 11.8 2.9 13 5.9 0.0 3.9 4 0 0 4 4 3 0 Shikimate kinase MobB PF03205.14 EFX05719.1 - 0.55 10.1 2.2 20 5.1 0.1 4.2 5 0 0 5 5 4 0 Molybdopterin guanine dinucleotide synthesis protein B Mito_carr PF00153.27 EFX05720.1 - 9.8e-46 153.6 2.5 1.9e-18 66.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1857 PF08982.11 EFX05721.1 - 3.7e-47 159.8 0.0 4.2e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) Gar1 PF04410.14 EFX05723.1 - 2.7e-35 121.4 4.4 5.5e-18 65.2 0.0 3.0 3 0 0 3 3 3 2 Gar1/Naf1 RNA binding region SH3_9 PF14604.6 EFX05723.1 - 3.4e-10 39.6 0.0 6.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFX05723.1 - 0.00019 21.0 0.0 0.00034 20.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain DNA_pol_phi PF04931.13 EFX05723.1 - 4.3 5.3 14.6 8.8 4.3 14.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_S21 PF01165.20 EFX05724.1 - 2.7e-18 65.4 2.5 4.8e-18 64.6 2.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 muHD PF10291.9 EFX05725.1 - 3.5e-62 210.2 0.0 6.9e-62 209.3 0.0 1.5 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EFX05725.1 - 5e-07 29.9 1.5 1.1e-06 28.9 0.0 2.3 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain GCP_C_terminal PF04130.13 EFX05725.1 - 0.065 12.7 0.3 0.11 12.0 0.3 1.3 1 0 0 1 1 1 0 Gamma tubulin complex component C-terminal BPL_N PF09825.9 EFX05725.1 - 0.1 11.7 6.0 0.16 11.0 6.0 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF4169 PF13770.6 EFX05725.1 - 1.1 9.6 5.6 0.56 10.5 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4169) MFS_1 PF07690.16 EFX05726.1 - 9.1e-19 67.6 56.1 6.2e-10 38.5 32.2 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF4713 PF15831.5 EFX05726.1 - 0.24 11.9 5.0 0.29 11.6 0.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) IDO PF01231.18 EFX05727.1 - 6e-146 486.6 0.0 6.9e-146 486.4 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DLEU7 PF15760.5 EFX05727.1 - 0.14 11.6 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 Leukemia-associated protein 7 MitMem_reg PF13012.6 EFX05729.1 - 7.9e-09 35.9 0.0 2.4e-08 34.4 0.0 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFX05729.1 - 1e-08 35.1 0.0 2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Senescence PF06911.12 EFX05730.1 - 5.4e-52 176.8 7.7 1.1e-51 175.8 7.7 1.5 1 0 0 1 1 1 1 Senescence-associated protein She9_MDM33 PF05546.11 EFX05731.1 - 1.3e-77 260.1 3.2 2e-77 259.5 3.2 1.3 1 0 0 1 1 1 1 She9 / Mdm33 family ADIP PF11559.8 EFX05731.1 - 0.028 14.5 2.2 4.1 7.5 1.2 3.0 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding AAA_5 PF07728.14 EFX05731.1 - 0.072 13.1 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) BCAS2 PF05700.11 EFX05731.1 - 0.1 12.3 5.4 0.05 13.3 1.0 2.4 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) DUF4407 PF14362.6 EFX05731.1 - 1.3 8.3 9.7 3.5 6.9 9.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sfi1 PF08457.10 EFX05732.1 - 1.2e-60 205.7 90.5 2.9e-59 201.1 88.4 2.1 2 0 0 2 2 2 2 Sfi1 spindle body protein Radial_spoke PF04712.12 EFX05732.1 - 1.5 7.7 12.7 4.4 6.1 1.9 3.4 3 0 0 3 3 3 0 Radial spokehead-like protein YL1 PF05764.13 EFX05732.1 - 1.6 8.7 35.9 2.4 8.2 4.4 5.7 4 1 0 5 5 5 0 YL1 nuclear protein CPSF100_C PF13299.6 EFX05732.1 - 2.4 8.3 10.4 6 7.0 0.5 3.6 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Sigma70_ner PF04546.13 EFX05732.1 - 5.5 6.8 38.3 1.8 8.4 4.3 4.5 4 0 0 4 4 4 0 Sigma-70, non-essential region adh_short PF00106.25 EFX05733.1 - 1.2e-34 119.5 0.1 1.6e-34 119.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX05733.1 - 8.5e-24 84.4 0.0 1e-23 84.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX05733.1 - 0.00042 20.3 1.3 0.00081 19.4 1.3 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFX05733.1 - 0.005 16.7 0.8 0.01 15.7 0.2 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 EFX05733.1 - 0.014 14.9 0.2 0.025 14.1 0.2 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 EFX05733.1 - 0.027 13.8 0.1 0.046 13.1 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 4HBT PF03061.22 EFX05734.1 - 0.05 14.0 0.1 0.35 11.2 0.1 2.2 2 0 0 2 2 2 0 Thioesterase superfamily p450 PF00067.22 EFX05735.1 - 0.00013 20.8 0.0 0.00015 20.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_1 PF00175.21 EFX05736.1 - 1e-31 109.8 0.0 1.6e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFX05736.1 - 9.8e-27 93.2 0.0 1.8e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 EFX05736.1 - 2.3e-18 66.1 0.1 3.8e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EFX05736.1 - 0.00047 20.3 0.0 0.0051 17.0 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EFX05736.1 - 0.095 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain CusF_Ec PF11604.8 EFX05736.1 - 0.11 12.5 0.0 4.3 7.4 0.0 2.4 2 0 0 2 2 2 0 Copper binding periplasmic protein CusF ATP-synt_S1 PF05827.12 EFX05738.1 - 1.7e-05 24.7 0.1 3.1e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) VASt PF16016.5 EFX05740.1 - 4.2e-41 140.9 0.3 7.3e-40 136.9 0.0 2.2 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EFX05740.1 - 1.2e-22 80.0 0.0 2e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 GRAM domain 4F5 PF04419.14 EFX05741.1 - 9.6e-06 26.4 9.1 9.6e-06 26.4 9.1 1.6 1 1 1 2 2 2 1 4F5 protein family zf-met2 PF12907.7 EFX05741.1 - 0.0028 17.7 0.5 0.0059 16.7 0.5 1.6 1 0 0 1 1 1 1 Zinc-binding Eapp_C PF10238.9 EFX05741.1 - 0.11 12.6 2.9 0.12 12.4 2.9 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein NAD_binding_2 PF03446.15 EFX05742.1 - 1.2e-26 93.7 0.4 2e-26 93.1 0.4 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFX05742.1 - 2e-09 37.8 0.0 4.1e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EFX05742.1 - 0.043 13.9 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Zn_clus PF00172.18 EFX05743.1 - 1.1e-08 35.0 7.8 1.1e-08 35.0 7.8 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sas10_Utp3 PF04000.15 EFX05744.1 - 5.6e-15 55.7 2.3 5.6e-15 55.7 2.3 1.7 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Pes-10 PF07149.11 EFX05744.1 - 0.5 9.4 2.8 0.77 8.8 2.8 1.2 1 0 0 1 1 1 0 Pes-10 CDV3 PF15359.6 EFX05744.1 - 1.2 9.7 6.6 0.27 11.7 3.0 1.8 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 TIM21 PF08294.11 EFX05745.1 - 1.2e-43 148.5 0.2 1.6e-43 148.1 0.2 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EFX05745.1 - 3.4e-06 26.8 0.0 9.9e-06 25.3 0.0 1.8 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Asp4 PF16996.5 EFX05745.1 - 0.11 12.3 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 Per1 PF04080.13 EFX05746.1 - 6.5e-105 350.5 2.5 8.3e-105 350.1 2.5 1.1 1 0 0 1 1 1 1 Per1-like family CCD PF07860.11 EFX05746.1 - 0.031 14.3 0.6 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 WisP family C-Terminal Region Spt5-NGN PF03439.13 EFX05747.1 - 8e-25 86.6 0.0 1.3e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 EFX05747.1 - 1.7e-20 73.9 11.4 1.7e-20 73.9 11.4 3.6 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 EFX05747.1 - 1.6e-19 70.3 28.9 2.5e-18 66.4 19.2 4.6 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.29 EFX05747.1 - 8.7e-10 38.2 25.3 4.5e-08 32.8 1.7 4.8 6 0 0 6 6 6 2 KOW motif DUF3912 PF13051.6 EFX05747.1 - 0.00027 21.1 0.9 0.017 15.4 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3912) Thioredoxin PF00085.20 EFX05748.1 - 1.2e-25 89.5 0.0 1.5e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EFX05748.1 - 7.9e-05 22.4 0.0 9.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFX05748.1 - 0.00047 20.6 0.1 0.012 16.1 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFX05748.1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like XPC-binding PF09280.11 EFX05748.1 - 0.066 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 XPC-binding domain OST3_OST6 PF04756.13 EFX05748.1 - 0.13 11.5 0.0 0.22 10.9 0.0 1.3 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family RRM_1 PF00076.22 EFX05749.1 - 8.4e-70 230.6 0.0 9e-17 60.7 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFX05749.1 - 1e-06 28.7 0.0 0.088 12.9 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif RRM_occluded PF16842.5 EFX05749.1 - 3.4e-06 26.8 0.2 4.3 7.3 0.0 5.1 6 0 0 6 6 6 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EFX05749.1 - 9.1e-05 22.1 0.0 0.049 13.2 0.0 3.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EFX05749.1 - 0.00036 20.4 0.0 9.8 6.0 0.0 4.4 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 EFX05749.1 - 0.0052 16.8 0.1 6.9 6.8 0.0 4.3 4 0 0 4 4 4 1 RNA binding motif Limkain-b1 PF11608.8 EFX05749.1 - 0.019 15.0 0.1 3.4 7.8 0.0 4.2 4 0 0 4 4 4 0 Limkain b1 CaM-KIIN PF15170.6 EFX05749.1 - 0.15 12.2 0.7 0.46 10.7 0.2 2.1 2 0 0 2 2 2 0 Calcium/calmodulin-dependent protein kinase II inhibitor Smg4_UPF3 PF03467.15 EFX05749.1 - 0.29 11.1 0.0 0.29 11.1 0.0 5.1 5 2 0 5 5 5 0 Smg-4/UPF3 family DUF4140 PF13600.6 EFX05749.1 - 0.53 10.7 0.0 0.53 10.7 0.0 4.4 4 1 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) Prp19 PF08606.11 EFX05750.1 - 2.6e-30 104.2 3.1 5.7e-30 103.1 3.1 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EFX05750.1 - 6.7e-14 52.0 0.0 0.0034 17.6 0.0 4.6 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFX05750.1 - 4.3e-11 43.2 3.2 0.23 12.4 0.0 6.6 6 0 0 6 6 6 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFX05750.1 - 8.2e-07 28.4 0.0 7.2e-06 25.3 0.0 2.0 1 1 0 1 1 1 1 Coatomer WD associated region WD40_like PF17005.5 EFX05750.1 - 3.2e-05 23.4 0.0 0.0044 16.4 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain zf-RING_5 PF14634.6 EFX05750.1 - 0.00036 20.4 2.1 0.0007 19.5 2.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFX05750.1 - 0.0031 17.5 0.4 0.0071 16.4 0.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 EFX05750.1 - 0.0034 17.2 0.3 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EFX05750.1 - 0.0066 16.3 0.4 0.017 15.0 0.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF5114 PF17141.4 EFX05750.1 - 0.0083 16.6 0.1 0.045 14.3 0.1 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5114) VID27 PF08553.10 EFX05750.1 - 0.0085 15.2 0.1 0.0085 15.2 0.1 1.7 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain V_ATPase_I_N PF18670.1 EFX05750.1 - 0.016 15.6 0.2 0.056 13.8 0.2 1.9 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain zf-C3HC4_2 PF13923.6 EFX05750.1 - 0.02 14.7 0.3 0.045 13.6 0.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cytochrom_D1 PF02239.16 EFX05750.1 - 0.034 12.7 0.1 4 5.9 0.0 2.4 2 0 0 2 2 2 0 Cytochrome D1 heme domain zf-C3HC4 PF00097.25 EFX05750.1 - 0.048 13.5 0.6 0.092 12.6 0.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EFX05750.1 - 0.13 11.6 0.3 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EFX05750.1 - 0.16 12.1 0.2 0.63 10.2 0.1 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFX05750.1 - 0.24 11.8 0.8 0.53 10.7 0.8 1.5 1 0 0 1 1 1 0 Ring finger domain IceA2 PF05862.11 EFX05750.1 - 0.49 10.3 1.7 3.8 7.5 0.0 3.2 3 0 0 3 3 3 0 Helicobacter pylori IceA2 protein zf-C3HC4_3 PF13920.6 EFX05750.1 - 0.55 10.1 3.4 0.44 10.5 1.0 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SR-25 PF10500.9 EFX05751.1 - 0.17 11.5 17.9 0.087 12.4 9.5 2.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Response_reg PF00072.24 EFX05752.1 - 2.4e-17 63.1 0.1 1e-12 48.2 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 EFX05752.1 - 2.3e-12 47.4 0.0 5.6e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFX05752.1 - 6.1e-08 32.6 0.1 6.1e-08 32.6 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EFX05752.1 - 0.00031 20.9 1.6 0.19 12.0 0.0 4.2 4 1 0 4 4 4 1 PAS fold PAS_9 PF13426.7 EFX05752.1 - 0.00043 20.5 0.0 0.017 15.4 0.0 3.1 2 1 0 2 2 2 1 PAS domain DUF4141 PF13605.6 EFX05752.1 - 0.0014 17.8 0.1 0.0039 16.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4141) PAS PF00989.25 EFX05752.1 - 0.0031 17.5 2.0 0.0057 16.6 0.0 2.6 2 2 2 4 4 4 1 PAS fold GAF_2 PF13185.6 EFX05752.1 - 0.0031 17.8 0.4 0.22 11.8 0.0 3.2 3 0 0 3 3 3 1 GAF domain PAS_8 PF13188.7 EFX05752.1 - 0.0044 17.0 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 EFX05752.1 - 0.032 14.5 0.9 0.14 12.5 0.1 2.3 2 0 0 2 2 2 0 PAS fold Ribosomal_L1 PF00687.21 EFX05755.1 - 2.3e-45 154.9 0.2 2.8e-45 154.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family M20_dimer PF07687.14 EFX05757.1 - 2e-06 27.7 0.1 3.6e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EFX05757.1 - 0.0011 18.7 0.2 0.0017 18.1 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 zf-C2H2_4 PF13894.6 EFX05758.1 - 0.0008 20.0 13.2 0.2 12.6 0.7 4.0 3 1 0 3 3 3 2 C2H2-type zinc finger DUF1677 PF07911.13 EFX05758.1 - 0.015 15.6 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1677) zf-C2H2 PF00096.26 EFX05758.1 - 0.11 13.0 15.0 0.86 10.2 2.9 3.8 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 EFX05758.1 - 1.8 8.9 5.5 2.5 8.5 1.0 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF4222 PF13973.6 EFX05758.1 - 2.7 7.7 6.6 8.3 6.1 1.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4222) Acetyltransf_7 PF13508.7 EFX05759.1 - 0.00072 19.9 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFX05759.1 - 0.026 14.6 0.0 0.067 13.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX05759.1 - 0.089 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family NACHT PF05729.12 EFX05760.1 - 1.6e-08 34.6 0.1 6.4e-08 32.7 0.1 2.1 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFX05760.1 - 1.2e-06 29.0 1.1 1e-05 26.0 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain KAP_NTPase PF07693.14 EFX05760.1 - 4e-05 23.0 0.0 0.29 10.3 0.1 2.5 1 1 1 2 2 2 2 KAP family P-loop domain AAA_22 PF13401.6 EFX05760.1 - 0.00038 20.7 0.8 0.0031 17.8 0.0 2.7 2 2 1 3 3 3 1 AAA domain NB-ARC PF00931.22 EFX05760.1 - 0.0012 18.1 0.3 0.014 14.6 0.0 2.9 3 1 0 3 3 3 1 NB-ARC domain AAA_5 PF07728.14 EFX05760.1 - 0.0036 17.3 0.2 0.09 12.8 0.1 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 EFX05760.1 - 0.0052 16.1 0.8 0.017 14.3 0.0 2.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 EFX05760.1 - 0.0094 16.3 0.0 0.3 11.5 0.0 2.8 2 0 0 2 2 2 1 RNA helicase TrwB_AAD_bind PF10412.9 EFX05760.1 - 0.048 12.6 2.8 11 4.8 0.0 3.7 4 0 0 4 4 4 0 Type IV secretion-system coupling protein DNA-binding domain AAA_11 PF13086.6 EFX05760.1 - 0.12 12.1 2.8 3.3 7.4 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA PF00004.29 EFX05760.1 - 0.13 12.7 0.0 0.62 10.5 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFX05760.1 - 4.5 7.8 5.5 1.4 9.5 0.3 2.9 3 1 0 3 3 3 0 AAA domain Rhodanese PF00581.20 EFX05761.1 - 3.5e-14 53.2 0.0 4.5e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain His_Phos_2 PF00328.22 EFX05762.1 - 3.8e-110 368.8 0.0 2.1e-109 366.4 0.0 2.1 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EFX05762.1 - 6.9e-36 122.3 0.0 1.4e-35 121.3 0.0 1.5 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EFX05762.1 - 2.5e-07 30.5 0.0 4.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Fungal_trans PF04082.18 EFX05764.1 - 9.7e-17 60.9 0.8 1.7e-16 60.1 0.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05764.1 - 1.3e-07 31.6 7.7 3.8e-07 30.1 7.7 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HNH_2 PF13391.6 EFX05765.1 - 0.056 13.6 0.1 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 HNH endonuclease DUF1194 PF06707.11 EFX05765.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) DASH_Ask1 PF08655.10 EFX05766.1 - 5.9e-17 61.3 0.1 1e-16 60.6 0.1 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 CHCH PF06747.13 EFX05767.1 - 0.025 14.7 0.6 0.051 13.7 0.6 1.6 1 1 0 1 1 1 0 CHCH domain Pet191_N PF10203.9 EFX05767.1 - 0.043 14.1 4.2 0.25 11.7 4.2 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Nop PF01798.18 EFX05769.1 - 2.2e-77 259.6 0.8 2.2e-77 259.6 0.8 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFX05769.1 - 9.2e-18 64.4 0.8 3.2e-17 62.6 0.1 2.5 2 0 0 2 2 2 1 NOP5NT (NUC127) domain HIG_1_N PF04588.13 EFX05771.1 - 1.2e-23 83.0 2.4 2.1e-23 82.3 2.4 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region zf-AN1 PF01428.16 EFX05772.1 - 1.2e-23 83.0 24.7 6.1e-12 45.5 9.9 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EFX05772.1 - 0.042 14.1 2.8 0.042 14.1 2.8 2.8 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 EFX05772.1 - 0.25 11.7 15.1 1.1 9.6 6.2 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Amidase PF01425.21 EFX05773.1 - 2.2e-80 270.8 0.0 5.7e-57 193.7 0.1 2.1 1 1 1 2 2 2 2 Amidase MFS_1 PF07690.16 EFX05775.1 - 1.6e-31 109.6 22.9 2e-31 109.2 22.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05775.1 - 1.1e-17 64.1 5.7 2.3e-17 63.0 5.7 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.13 EFX05775.1 - 3.9e-05 22.3 1.1 5.6e-05 21.7 1.1 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector PUCC PF03209.15 EFX05775.1 - 0.0013 17.8 8.3 0.0013 17.8 8.3 1.9 2 0 0 2 2 2 1 PUCC protein Vma12 PF11712.8 EFX05775.1 - 0.034 14.2 0.7 0.093 12.8 0.7 1.7 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF697 PF05128.12 EFX05775.1 - 0.055 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF697) OATP PF03137.20 EFX05775.1 - 0.16 10.2 8.7 0.12 10.7 2.2 2.6 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Homoserine_dh PF00742.19 EFX05776.1 - 1.2e-51 175.1 0.0 1.6e-51 174.7 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EFX05776.1 - 9.5e-19 68.2 0.0 1.6e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain CHASE2 PF05226.11 EFX05776.1 - 0.023 14.4 0.0 0.028 14.2 0.0 1.1 1 0 0 1 1 1 0 CHASE2 domain ApbA PF02558.16 EFX05776.1 - 0.16 11.6 0.2 0.36 10.5 0.2 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2OG-FeII_Oxy_3 PF13640.6 EFX05777.1 - 0.0009 20.1 0.1 0.0015 19.4 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-Fe_Oxy_2 PF10014.9 EFX05777.1 - 0.11 12.2 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 2OG-Fe dioxygenase Cyt-b5 PF00173.28 EFX05778.1 - 1.2e-16 60.6 2.1 1.3e-16 60.5 0.2 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EFX05778.1 - 4.2e-13 49.8 18.4 7.4e-13 49.0 17.3 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 EFX05778.1 - 0.014 15.6 0.1 0.029 14.6 0.1 1.5 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region ATP-synt_I PF03899.15 EFX05778.1 - 3.2 8.2 6.1 2.8 8.4 0.4 2.3 2 0 0 2 2 2 0 ATP synthase I chain 2OG-FeII_Oxy_2 PF13532.6 EFX05779.1 - 8.8e-27 94.6 0.0 2.1e-23 83.6 0.0 2.3 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily DUF2781 PF10914.8 EFX05780.1 - 7e-38 130.3 5.8 8.2e-38 130.1 5.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Vps5 PF09325.10 EFX05781.1 - 7e-10 38.8 0.9 1.1e-09 38.2 0.9 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EFX05781.1 - 3.9e-07 30.0 0.0 7.1e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 PX domain TPR_17 PF13431.6 EFX05781.1 - 0.052 13.9 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Seryl_tRNA_N PF02403.22 EFX05781.1 - 0.054 13.7 3.8 0.062 13.5 2.4 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TPR_12 PF13424.6 EFX05781.1 - 0.096 13.0 3.2 0.11 12.8 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NST1 PF13945.6 EFX05781.1 - 0.23 11.6 2.7 0.44 10.6 2.7 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator AbiEii PF08843.11 EFX05782.1 - 0.0009 19.3 0.0 0.0018 18.3 0.0 1.3 1 1 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system AIM24 PF01987.17 EFX05784.1 - 1.9e-51 174.7 0.1 2.4e-51 174.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF2201_N PF13203.6 EFX05785.1 - 0.065 12.8 0.2 0.079 12.5 0.2 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Furin-like PF00757.20 EFX05785.1 - 0.093 12.6 9.2 0.15 11.9 9.2 1.3 1 1 0 1 1 1 0 Furin-like cysteine rich region ABC_tran PF00005.27 EFX05787.1 - 7.9e-48 162.4 0.6 1.6e-27 96.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EFX05787.1 - 7.1e-23 81.9 0.8 3.6e-06 27.0 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFX05787.1 - 3.5e-22 79.0 50.8 5.8e-18 65.1 23.0 3.0 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_29 PF13555.6 EFX05787.1 - 1.8e-09 37.2 4.3 0.00073 19.2 0.3 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain SMC_N PF02463.19 EFX05787.1 - 1e-07 31.6 4.6 0.15 11.5 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFX05787.1 - 1.9e-07 31.1 1.7 0.0065 16.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EFX05787.1 - 1.6e-06 28.8 2.5 0.029 14.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFX05787.1 - 0.00012 22.5 2.7 0.52 10.7 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain DUF4162 PF13732.6 EFX05787.1 - 0.00071 20.2 0.0 1 10.1 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 EFX05787.1 - 0.00084 19.2 0.1 0.74 9.5 0.1 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 EFX05787.1 - 0.002 17.9 6.3 1.6 8.4 0.1 3.9 4 0 0 4 4 4 2 AAA domain MeaB PF03308.16 EFX05787.1 - 0.0029 16.7 0.6 0.25 10.3 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 EFX05787.1 - 0.0046 16.6 4.3 0.28 10.8 0.1 2.7 3 0 0 3 3 3 2 AAA domain SRP54 PF00448.22 EFX05787.1 - 0.011 15.4 0.2 6.3 6.4 0.1 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EFX05787.1 - 0.012 14.9 1.0 2.6 7.3 0.2 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 EFX05787.1 - 0.027 14.7 0.1 7.5 6.8 0.0 3.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFX05787.1 - 0.17 11.8 0.0 14 5.6 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain G-alpha PF00503.20 EFX05787.1 - 0.39 9.8 0.8 3.6 6.7 0.3 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AIG1 PF04548.16 EFX05787.1 - 0.94 8.8 2.6 2.4 7.4 0.5 2.3 2 0 0 2 2 2 0 AIG1 family AAA PF00004.29 EFX05787.1 - 1.4 9.4 3.6 22 5.5 0.1 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Mak10 PF04112.13 EFX05788.1 - 3.2e-24 85.3 0.0 5.4e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase CTK3 PF12243.8 EFX05789.1 - 2.2e-47 160.1 0.1 3.2e-47 159.6 0.1 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EFX05789.1 - 1.2e-19 70.2 11.4 1.2e-19 70.2 11.4 1.6 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus adh_short PF00106.25 EFX05790.1 - 4e-37 127.6 1.4 9.6e-37 126.3 1.4 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX05790.1 - 1.3e-27 96.9 0.4 1.9e-27 96.3 0.4 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX05790.1 - 1.6e-11 44.4 0.6 2.1e-11 44.1 0.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX05790.1 - 1.4e-08 34.5 0.1 1.8e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFX05790.1 - 1.8e-05 24.7 1.0 2.6e-05 24.2 1.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EFX05790.1 - 0.0023 17.2 0.7 0.027 13.6 0.7 2.4 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EFX05790.1 - 0.01 15.0 0.2 0.015 14.4 0.2 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFX05790.1 - 0.035 13.1 0.2 0.044 12.8 0.2 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFX05790.1 - 0.051 12.7 0.2 0.08 12.0 0.2 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DUF3842 PF12953.7 EFX05790.1 - 0.091 13.1 0.3 0.17 12.3 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) DUF3801 PF12687.7 EFX05790.1 - 0.15 12.1 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) DUF3402 PF11882.8 EFX05791.1 - 6.9e-201 668.3 0.1 1.2e-200 667.5 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EFX05791.1 - 1.9e-97 325.9 0.0 2.9e-97 325.3 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein NOA36 PF06524.12 EFX05791.1 - 0.55 9.5 4.6 0.88 8.8 4.6 1.2 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 EFX05791.1 - 0.65 9.4 4.6 1.2 8.5 4.6 1.4 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EFX05791.1 - 7.9 4.4 7.6 12 3.8 7.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi GMC_oxred_N PF00732.19 EFX05792.1 - 2.1e-09 37.2 0.0 8.4e-09 35.2 0.0 1.9 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX05792.1 - 2.6e-08 34.5 2.9 9.6e-08 32.7 0.4 2.9 3 0 0 3 3 3 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EFX05792.1 - 0.00052 19.2 0.4 0.00093 18.4 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFX05792.1 - 0.0027 17.1 0.0 0.0057 16.1 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EFX05792.1 - 0.0057 15.8 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EFX05792.1 - 0.0082 15.4 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX05792.1 - 0.029 14.6 0.3 0.11 12.8 0.3 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain UDPG_MGDP_dh_N PF03721.14 EFX05792.1 - 0.36 10.4 0.8 1.6 8.3 0.2 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Tyrosinase PF00264.20 EFX05793.1 - 2.2e-49 168.7 5.1 8.4e-49 166.8 3.3 2.2 2 0 0 2 2 2 1 Common central domain of tyrosinase SprB PF13573.6 EFX05793.1 - 0.053 13.3 3.0 0.15 11.8 3.0 1.8 1 0 0 1 1 1 0 SprB repeat Ribosomal_L34 PF00468.17 EFX05793.1 - 0.098 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L34 Yippee-Mis18 PF03226.14 EFX05794.1 - 1.1e-15 57.7 0.2 1.3e-15 57.5 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EFX05794.1 - 0.032 14.4 0.2 0.051 13.8 0.2 1.3 1 0 0 1 1 1 0 C-terminal domain of RIG-I NUDIX PF00293.28 EFX05795.1 - 1.3e-16 60.8 0.1 2.5e-16 59.9 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EFX05795.1 - 2.8e-15 56.8 0.4 8.7e-14 52.0 0.1 2.5 2 1 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EFX05795.1 - 1.1e-08 34.6 0.6 1.9e-08 33.8 0.6 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain ATP-synt_G PF04718.15 EFX05796.1 - 2.1e-32 111.9 0.5 3.8e-32 111.1 0.1 1.6 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Pap_E4 PF02711.14 EFX05796.1 - 0.25 12.3 2.6 0.42 11.6 2.6 1.3 1 0 0 1 1 1 0 E4 protein Sporozoite_P67 PF05642.11 EFX05796.1 - 1.3 7.0 4.8 1.6 6.7 4.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SR-25 PF10500.9 EFX05796.1 - 1.6 8.3 10.5 2.2 7.8 10.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 EFX05796.1 - 8.4 4.5 5.4 10 4.3 5.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DHR10 PF18595.1 EFX05798.1 - 0.12 12.4 2.2 0.17 11.9 0.4 2.2 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain CdvA PF18822.1 EFX05798.1 - 0.18 11.6 5.5 0.49 10.2 0.2 3.5 4 0 0 4 4 4 0 CdvA-like coiled-coil domain Baculo_PEP_C PF04513.12 EFX05798.1 - 0.23 11.5 4.9 5.8 7.0 0.1 3.5 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Peptidase_S8 PF00082.22 EFX05799.1 - 2.5e-41 141.9 10.0 5.8e-41 140.7 8.2 2.1 2 0 0 2 2 2 1 Subtilase family fn3_5 PF06280.12 EFX05799.1 - 7.9e-14 52.3 1.4 1.3e-12 48.5 0.3 3.0 3 0 0 3 3 3 1 Fn3-like domain PA PF02225.22 EFX05799.1 - 1.1e-07 31.8 0.1 5.1e-07 29.6 0.1 2.2 1 0 0 1 1 1 1 PA domain FlgD_ig PF13860.6 EFX05799.1 - 0.0069 16.2 0.1 0.027 14.3 0.1 2.0 1 0 0 1 1 1 1 FlgD Ig-like domain Sugar_tr PF00083.24 EFX05800.1 - 7.8e-90 301.9 24.0 9.1e-90 301.7 24.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05800.1 - 1.7e-31 109.4 51.7 7.9e-24 84.2 26.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFX05800.1 - 6.6e-06 24.7 1.2 6.6e-06 24.7 1.2 2.2 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family TssN PF17555.2 EFX05800.1 - 0.53 9.6 4.6 0.1 12.0 0.4 1.9 2 1 0 2 2 2 0 Type VI secretion system, TssN tRNA-synt_1b PF00579.25 EFX05801.1 - 3.6e-23 82.3 0.0 5.4e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) SET PF00856.28 EFX05802.1 - 1.5e-13 51.5 0.0 4.4e-13 50.0 0.0 1.8 1 1 0 1 1 1 1 SET domain SAF PF08666.12 EFX05802.1 - 0.06 14.0 0.0 15 6.3 0.0 2.7 2 0 0 2 2 2 0 SAF domain TPR_8 PF13181.6 EFX05802.1 - 0.15 12.3 1.3 1.2 9.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFX05802.1 - 0.39 11.7 1.8 0.73 10.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CBFD_NFYB_HMF PF00808.23 EFX05803.1 - 5.3e-26 90.7 1.4 9.4e-26 89.9 1.4 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFX05803.1 - 1.3e-06 28.8 0.0 1.9e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 EFX05803.1 - 0.0022 18.0 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 EFX05803.1 - 0.0031 17.5 0.0 0.0051 16.8 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 EFX05803.1 - 0.029 14.5 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EFX05803.1 - 0.1 13.1 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A SelK_SelG PF10961.8 EFX05803.1 - 2.7 8.7 7.4 0.14 12.7 1.0 2.2 2 1 1 3 3 3 0 Selenoprotein SelK_SelG RNA_pol PF00940.19 EFX05804.1 - 3.3e-186 619.1 0.0 5.1e-186 618.5 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EFX05804.1 - 1.8e-102 343.2 6.0 1.8e-102 343.2 6.0 2.4 2 0 0 2 2 2 2 DNA-directed RNA polymerase N-terminal PK PF00224.21 EFX05805.1 - 1.7e-170 566.5 4.2 2.1e-170 566.2 4.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EFX05805.1 - 4.8e-35 120.3 0.0 1.2e-34 119.1 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EFX05805.1 - 0.00053 19.2 0.5 0.0025 17.0 0.2 2.1 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family MazE_antitoxin PF04014.18 EFX05805.1 - 0.11 12.4 0.0 1.7 8.6 0.0 2.9 3 0 0 3 3 3 0 Antidote-toxin recognition MazE, bacterial antitoxin DJ-1_PfpI PF01965.24 EFX05806.1 - 3.4e-11 43.2 0.0 8.8e-10 38.6 0.0 2.4 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EFX05806.1 - 7.6e-10 38.8 0.0 1e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 ThiJ/PfpI family-like GATase_3 PF07685.14 EFX05806.1 - 0.076 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain CN_hydrolase PF00795.22 EFX05807.1 - 8e-49 166.3 0.0 1.1e-48 165.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF1356 PF07092.12 EFX05808.1 - 0.085 12.1 0.2 1.1 8.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1356) DUF373 PF04123.13 EFX05808.1 - 0.58 9.5 5.2 0.84 9.0 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF3185 PF11381.8 EFX05808.1 - 2.2 8.3 9.5 2.7 8.1 7.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) K_oxygenase PF13434.6 EFX05810.1 - 5.5e-107 357.9 0.0 5.9e-105 351.2 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFX05810.1 - 5.4e-07 29.1 0.0 2.3e-05 23.8 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX05810.1 - 1.1e-05 24.9 0.0 0.0013 18.1 0.0 3.4 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX05810.1 - 0.0003 20.8 0.0 0.0028 17.7 0.0 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding PilX PF13681.6 EFX05810.1 - 0.083 13.3 0.1 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 Type IV pilus assembly protein PilX C-term Copper-fist PF00649.18 EFX05811.1 - 3.1e-21 74.6 2.0 3.1e-21 74.6 2.0 3.6 1 1 3 4 4 4 1 Copper fist DNA binding domain Fungal_trans PF04082.18 EFX05814.1 - 0.0022 17.1 0.0 0.004 16.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ras PF00071.22 EFX05815.1 - 1.5e-57 193.7 0.0 1.7e-57 193.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX05815.1 - 3.5e-34 117.6 0.0 5.1e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX05815.1 - 1.4e-13 50.7 0.0 2.8e-13 49.7 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFX05815.1 - 7.7e-06 25.6 0.0 1.1e-05 25.1 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFX05815.1 - 4.4e-05 23.5 0.0 0.00014 22.0 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFX05815.1 - 0.00018 20.9 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EFX05815.1 - 0.0008 19.8 0.1 0.0011 19.4 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain Ferrochelatase PF00762.19 EFX05816.1 - 9e-98 327.2 0.0 1.1e-97 326.9 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase eRF1_1 PF03463.15 EFX05818.1 - 6.4e-33 113.5 0.1 1.1e-32 112.7 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EFX05818.1 - 9.1e-16 58.3 0.0 2.2e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EFX05818.1 - 1e-15 58.2 0.1 1.7e-15 57.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 Guanylate_cyc_2 PF09778.9 EFX05818.1 - 0.081 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Guanylylate cyclase DUF3494 PF11999.8 EFX05820.1 - 2.3e-54 184.2 18.4 3.1e-54 183.8 18.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3494) HhH-GPD PF00730.25 EFX05821.1 - 0.0014 19.1 0.0 0.0033 17.9 0.0 1.6 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein TT_ORF2 PF02957.15 EFX05821.1 - 0.1 13.5 0.4 6.7 7.6 0.0 2.6 2 0 0 2 2 2 0 TT viral ORF2 AAA_7 PF12775.7 EFX05822.1 - 0.035 13.6 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Methyltransf_11 PF08241.12 EFX05823.1 - 1.1e-18 67.6 0.0 3.3e-18 66.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05823.1 - 1.6e-16 60.8 0.0 3.2e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05823.1 - 3.9e-11 43.0 0.0 5.2e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05823.1 - 2.3e-08 34.7 0.0 3.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX05823.1 - 4.3e-07 29.5 0.0 6.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFX05823.1 - 0.026 14.3 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 EFX05823.1 - 0.096 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_18 PF12847.7 EFX05823.1 - 0.17 11.8 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain ECH_1 PF00378.20 EFX05824.1 - 4.4e-54 183.4 0.0 1.7e-53 181.5 0.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFX05824.1 - 9.3e-26 91.1 0.7 2.2e-25 89.9 0.7 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase MFS_1 PF07690.16 EFX05825.1 - 1.3e-13 50.6 20.0 1.8e-13 50.1 20.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4500 PF14937.6 EFX05825.1 - 0.091 12.8 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) DHHC PF01529.20 EFX05826.1 - 2.1e-28 99.1 0.2 2.1e-28 99.1 0.2 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase SNRNP27 PF08648.12 EFX05829.1 - 5.9e-05 23.1 0.3 0.0002 21.4 0.3 2.0 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2_jaz PF12171.8 EFX05829.1 - 0.00011 22.4 0.1 0.00016 21.8 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX05829.1 - 0.0098 16.3 0.3 0.015 15.7 0.3 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Atg14 PF10186.9 EFX05829.1 - 0.32 10.0 6.0 0.035 13.2 1.4 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3340 PF11818.8 EFX05829.1 - 2.6 8.2 14.3 0.46 10.6 5.0 2.1 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) DUF4192 PF13830.6 EFX05829.1 - 4.1 7.4 22.1 0.15 12.1 13.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) KAR9 PF08580.10 EFX05830.1 - 2.7e-172 574.9 0.0 2.7e-172 574.9 0.0 2.0 2 0 0 2 2 2 1 Yeast cortical protein KAR9 PLU-1 PF08429.11 EFX05830.1 - 0.28 10.3 2.8 1.2 8.2 0.0 2.7 2 1 1 3 3 3 0 PLU-1-like protein Syntaxin-6_N PF09177.11 EFX05830.1 - 9 6.9 8.7 4.6 7.9 1.5 3.5 2 2 2 4 4 4 0 Syntaxin 6, N-terminal Fungal_trans PF04082.18 EFX05831.1 - 2.6e-17 62.7 0.0 4e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05831.1 - 1.7e-06 28.0 9.3 1.7e-06 28.0 9.3 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FtsJ PF01728.19 EFX05832.1 - 9.6e-62 208.2 0.0 1.3e-61 207.8 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase HAD_SAK_1 PF10307.9 EFX05833.1 - 7e-75 251.3 0.0 9.5e-75 250.9 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins Arginase PF00491.21 EFX05834.1 - 1.3e-78 264.3 0.5 3.6e-69 233.4 0.0 2.0 2 0 0 2 2 2 2 Arginase family AP_endonuc_2 PF01261.24 EFX05835.1 - 1.1e-37 129.5 1.7 1.5e-37 129.1 1.7 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel SKG6 PF08693.10 EFX05836.1 - 3e-06 26.5 4.5 3e-06 26.5 4.5 2.4 3 0 0 3 3 3 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EFX05836.1 - 9.6e-05 22.2 0.3 0.00015 21.6 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Podoplanin PF05808.11 EFX05836.1 - 0.00017 21.7 2.9 0.00032 20.9 2.9 1.5 1 0 0 1 1 1 1 Podoplanin WSC PF01822.19 EFX05836.1 - 0.00027 21.1 9.3 0.00063 19.9 9.3 1.6 1 0 0 1 1 1 1 WSC domain Amnionless PF14828.6 EFX05836.1 - 0.0016 17.4 0.1 0.0021 16.9 0.1 1.2 1 0 0 1 1 1 1 Amnionless Rax2 PF12768.7 EFX05836.1 - 0.005 16.3 0.1 0.0082 15.6 0.1 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity PTP_tm PF18861.1 EFX05836.1 - 0.0054 16.7 0.4 0.011 15.8 0.4 1.5 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Sulf_transp PF04143.14 EFX05836.1 - 0.0086 15.7 0.4 0.012 15.2 0.4 1.2 1 0 0 1 1 1 1 Sulphur transport EphA2_TM PF14575.6 EFX05836.1 - 0.012 16.5 0.1 0.041 14.7 0.0 2.0 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2207 PF09972.9 EFX05836.1 - 0.022 13.5 0.1 0.029 13.1 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM154 PF15102.6 EFX05836.1 - 0.025 14.5 2.0 0.047 13.6 2.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family DUF5305 PF17231.2 EFX05836.1 - 0.03 13.7 2.6 0.055 12.9 2.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Romo1 PF10247.9 EFX05836.1 - 0.051 13.9 0.3 0.26 11.7 0.1 2.1 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 RIFIN PF02009.16 EFX05836.1 - 0.065 13.1 0.2 0.08 12.8 0.2 1.2 1 0 0 1 1 1 0 Rifin Tmemb_9 PF05434.11 EFX05836.1 - 0.075 12.9 0.3 1 9.3 0.9 2.2 2 0 0 2 2 2 0 TMEM9 DUF4381 PF14316.6 EFX05836.1 - 0.096 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Stevor PF17410.2 EFX05836.1 - 0.15 11.6 0.6 0.34 10.4 0.6 1.6 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame MtrF PF09472.10 EFX05836.1 - 0.19 11.1 2.5 0.44 10.0 2.5 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF3185 PF11381.8 EFX05836.1 - 1.2 9.2 7.0 11 6.1 6.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3185) Fes1 PF08609.10 EFX05837.1 - 0.019 15.8 0.5 0.1 13.5 0.5 2.3 1 0 0 1 1 1 0 Nucleotide exchange factor Fes1 Spt20 PF12090.8 EFX05837.1 - 0.36 10.4 7.6 0.71 9.5 7.6 1.4 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 EFX05837.1 - 9.7 6.3 14.5 0.53 10.4 7.7 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Peptidase_S49_N PF08496.10 EFX05837.1 - 9.8 6.2 10.9 0.59 10.2 1.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal p450 PF00067.22 EFX05838.1 - 3.4e-73 247.0 0.0 4.5e-73 246.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 EFX05838.1 - 2.9e-26 92.4 0.0 6.5e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EFX05838.1 - 1.4e-21 77.1 0.0 1.7e-20 73.6 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EFX05838.1 - 2.6e-11 44.1 0.0 7.1e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFX05838.1 - 0.04 14.1 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Flavodoxin_NdrI PF07972.11 EFX05838.1 - 0.058 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 NrdI Flavodoxin like Chitin_synth_2 PF03142.15 EFX05839.1 - 5e-23 81.5 5.8 8.2e-20 70.9 4.1 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EFX05839.1 - 5.9e-16 59.0 11.0 5.9e-16 59.0 11.0 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EFX05839.1 - 5e-12 46.2 0.1 1.3e-11 44.8 0.1 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFX05839.1 - 0.0087 15.9 0.2 4.3 7.1 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 HORMA PF02301.18 EFX05840.1 - 3.6e-08 33.3 0.0 0.0001 22.0 0.0 2.2 2 0 0 2 2 2 2 HORMA domain YL1 PF05764.13 EFX05840.1 - 0.065 13.3 5.4 0.039 14.1 3.8 1.3 1 1 0 1 1 1 0 YL1 nuclear protein DNA_pol_phi PF04931.13 EFX05840.1 - 1.3 7.1 4.6 1.9 6.5 4.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFX05840.1 - 6.3 6.0 6.7 9.3 5.5 6.7 1.2 1 0 0 1 1 1 0 NOA36 protein NACHT PF05729.12 EFX05841.1 - 5.6e-05 23.1 0.0 0.00043 20.2 0.0 2.4 3 0 0 3 3 3 1 NACHT domain Torsin PF06309.11 EFX05841.1 - 0.0037 17.3 0.0 0.013 15.6 0.0 1.8 2 0 0 2 2 2 1 Torsin WD40 PF00400.32 EFX05841.1 - 0.0069 17.2 0.1 0.072 14.0 0.0 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat CNF1 PF05785.12 EFX05841.1 - 0.0085 15.4 0.0 3.1 7.0 0.0 2.3 2 0 0 2 2 2 2 Rho-activating domain of cytotoxic necrotizing factor RNA_helicase PF00910.22 EFX05841.1 - 0.017 15.5 0.0 0.042 14.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 EFX05841.1 - 0.019 14.2 0.0 0.041 13.1 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 EFX05841.1 - 0.039 14.2 0.0 0.93 9.8 0.0 3.2 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EFX05841.1 - 0.11 12.9 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain PQQ_3 PF13570.6 EFX05841.1 - 0.38 11.3 6.7 4.9 7.8 0.4 4.4 4 0 0 4 4 4 0 PQQ-like domain Acetyltransf_1 PF00583.25 EFX05842.1 - 5.7e-11 42.7 0.0 7.3e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX05842.1 - 6.4e-08 32.6 0.0 8.5e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX05842.1 - 4e-06 27.2 0.1 6.7e-06 26.4 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX05842.1 - 0.0035 17.3 0.7 0.42 10.6 0.1 2.3 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_9 PF13527.7 EFX05842.1 - 0.061 13.4 0.0 0.22 11.6 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EFX05843.1 - 1.1e-68 231.5 0.0 2e-68 230.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX05843.1 - 5.8e-36 124.1 0.0 1.6e-35 122.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase SWIB PF02201.18 EFX05843.1 - 3.3e-12 46.1 0.0 8.7e-12 44.8 0.0 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain TFIIA PF03153.13 EFX05843.1 - 1.5e-05 25.2 27.2 1.5e-05 25.2 27.2 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Kinase-like PF14531.6 EFX05843.1 - 0.001 18.5 0.2 0.081 12.2 0.0 2.7 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EFX05843.1 - 0.0038 16.2 0.0 0.0072 15.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFX05843.1 - 0.012 15.6 0.0 0.012 15.6 0.0 2.8 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EFX05843.1 - 0.02 14.2 0.0 0.02 14.2 0.0 1.7 2 0 0 2 2 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFX05843.1 - 0.037 13.7 5.3 4.4 6.9 0.0 3.5 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 TERB2 PF15101.6 EFX05843.1 - 0.97 9.5 6.8 2.7 8.0 6.8 1.7 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Med15 PF09606.10 EFX05843.1 - 2.2 6.8 54.0 0.2 10.3 49.0 1.7 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal EPL1 PF10513.9 EFX05843.1 - 2.4 8.6 7.0 1.4 9.3 3.0 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like RTA1 PF04479.13 EFX05844.1 - 4.3e-66 222.5 4.6 5.4e-66 222.1 4.6 1.1 1 0 0 1 1 1 1 RTA1 like protein CrgA PF06781.12 EFX05844.1 - 0.37 10.9 0.2 0.37 10.9 0.2 2.8 4 0 0 4 4 4 0 Cell division protein CrgA DUF4233 PF14017.6 EFX05844.1 - 3.1 8.2 13.8 1.2 9.5 0.2 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF4233) DUF1748 PF08520.10 EFX05846.1 - 8.2e-34 115.3 0.1 1.1e-33 115.0 0.1 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) MFS_1 PF07690.16 EFX05847.1 - 1.1e-14 54.1 33.5 1.1e-14 54.1 33.5 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFX05847.1 - 1.8e-05 24.5 5.5 1.8e-05 24.5 5.5 3.4 2 1 3 5 5 5 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EFX05847.1 - 1.9e-05 23.7 5.3 3.4e-05 22.9 5.3 1.6 1 0 0 1 1 1 1 Sugar (and other) transporter PUCC PF03209.15 EFX05847.1 - 0.0086 15.1 0.1 0.0086 15.1 0.1 2.4 2 1 1 3 3 3 1 PUCC protein bZIP_1 PF00170.21 EFX05848.1 - 0.00013 22.0 5.8 0.00027 20.9 5.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor p450 PF00067.22 EFX05849.1 - 3.6e-49 167.8 0.0 5.7e-49 167.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Phage_GPD PF05954.11 EFX05850.1 - 0.67 9.2 4.1 0.36 10.1 0.6 1.9 2 0 0 2 2 2 0 Phage late control gene D protein (GPD) DUF2014 PF09427.10 EFX05851.1 - 7.8e-104 346.7 0.2 1.5e-103 345.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 EFX05851.1 - 2.4e-16 59.4 1.1 5.1e-16 58.4 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CopD PF05425.13 EFX05851.1 - 2.6 8.5 6.5 1.7 9.1 1.2 2.7 2 0 0 2 2 2 0 Copper resistance protein D LysM PF01476.20 EFX05852.1 - 2.6e-22 78.6 0.2 2.7e-05 24.1 0.0 5.5 5 0 0 5 5 5 5 LysM domain HRI1 PF16815.5 EFX05853.1 - 1.6e-73 247.2 2.2 1.8e-73 247.0 2.2 1.0 1 0 0 1 1 1 1 Protein HRI1 p450 PF00067.22 EFX05854.1 - 3.5e-67 227.1 0.0 4.6e-67 226.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AAA PF00004.29 EFX05855.1 - 2.4e-47 160.7 0.0 4.7e-42 143.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX05855.1 - 1.8e-08 34.1 0.1 6.5e-08 32.3 0.0 2.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 EFX05855.1 - 2.7e-07 31.2 0.1 0.0017 18.8 0.3 3.5 2 1 0 2 2 2 2 AAA ATPase domain IstB_IS21 PF01695.17 EFX05855.1 - 3.1e-06 27.1 0.0 0.00011 22.1 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 EFX05855.1 - 1.1e-05 25.6 0.0 2.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Bromodomain PF00439.25 EFX05855.1 - 0.00055 20.0 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 Bromodomain RuvB_N PF05496.12 EFX05855.1 - 0.00063 19.5 0.1 0.026 14.3 0.0 2.6 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain TMP_2 PF06791.13 EFX05855.1 - 0.0015 18.2 0.4 0.085 12.5 0.5 2.3 2 0 0 2 2 2 1 Prophage tail length tape measure protein AAA_22 PF13401.6 EFX05855.1 - 0.0018 18.6 0.2 0.059 13.6 0.2 3.0 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.14 EFX05855.1 - 0.0021 18.1 0.0 0.0087 16.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFX05855.1 - 0.012 14.8 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 EFX05855.1 - 0.013 16.0 0.0 0.052 14.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EFX05855.1 - 0.024 13.7 0.0 0.19 10.8 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 EFX05855.1 - 0.031 14.7 0.0 0.084 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 EFX05855.1 - 0.031 14.5 0.0 0.031 14.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFX05855.1 - 0.037 14.6 0.0 0.43 11.1 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.6 EFX05855.1 - 0.06 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EFX05855.1 - 0.065 12.6 0.9 0.17 11.2 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 EFX05855.1 - 0.066 12.4 0.1 7.5 5.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activ_2 PF14532.6 EFX05855.1 - 0.089 12.9 0.0 2.9 8.0 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain NACHT PF05729.12 EFX05855.1 - 0.1 12.5 0.1 0.92 9.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EFX05855.1 - 0.14 11.9 0.4 5.3 6.7 0.0 3.0 4 0 0 4 4 3 0 Sigma-54 interaction domain AAA_3 PF07726.11 EFX05855.1 - 0.14 12.0 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EFX05855.1 - 0.15 12.1 0.0 0.77 9.8 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ketoacyl-synt PF00109.26 EFX05857.1 - 5.7e-74 248.9 0.1 3.3e-73 246.4 0.0 2.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFX05857.1 - 1.2e-33 115.6 0.3 2.3e-33 114.7 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SAT PF16073.5 EFX05857.1 - 1.5e-10 41.3 0.0 2.7e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis KAsynt_C_assoc PF16197.5 EFX05857.1 - 1.5e-08 35.1 0.0 1.2e-07 32.1 0.0 2.3 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EFX05857.1 - 8.1e-07 28.7 0.1 1.4e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 EFX05857.1 - 0.0013 18.5 0.8 0.0053 16.6 0.2 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Acetyltransf_18 PF18014.1 EFX05857.1 - 0.031 14.1 0.0 0.47 10.3 0.0 2.6 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain His_Phos_1 PF00300.22 EFX05860.1 - 0.00065 19.4 5.0 2.8 7.6 0.0 4.3 4 1 1 5 5 5 3 Histidine phosphatase superfamily (branch 1) Vps8 PF12816.7 EFX05861.1 - 5.8e-73 244.6 0.0 1.7e-72 243.1 0.0 1.9 3 0 0 3 3 3 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EFX05861.1 - 6.2e-05 22.9 0.0 0.98 9.3 0.0 3.6 2 1 1 3 3 3 2 Region in Clathrin and VPS zf-RING_5 PF14634.6 EFX05861.1 - 0.003 17.5 0.1 0.0078 16.1 0.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3H2C3 PF17122.5 EFX05861.1 - 0.013 15.5 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger zf-RING_UBOX PF13445.6 EFX05861.1 - 0.029 14.4 0.3 0.069 13.2 0.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EFX05861.1 - 0.038 14.3 0.1 0.09 13.1 0.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 EFX05861.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Nup84_Nup100 PF04121.13 EFX05864.1 - 1.6e-151 505.9 0.0 1.9e-151 505.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TEX19 PF15553.6 EFX05865.1 - 0.0057 16.6 0.1 0.007 16.3 0.1 1.2 1 0 0 1 1 1 1 Testis-expressed protein 19 zf-Di19 PF05605.12 EFX05866.1 - 0.022 15.0 0.0 0.047 14.0 0.0 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EFX05866.1 - 0.052 14.4 0.1 0.12 13.3 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EFX05866.1 - 0.059 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Bap31_Bap29_C PF18035.1 EFX05866.1 - 0.09 12.8 0.5 0.26 11.3 0.5 1.7 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain zf-C2H2 PF00096.26 EFX05866.1 - 0.13 12.8 0.1 0.25 11.9 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-ribbon_3 PF13248.6 EFX05866.1 - 0.21 11.0 0.2 0.41 10.1 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain CBF PF03914.17 EFX05867.1 - 5.1e-54 182.8 0.3 5.1e-54 182.8 0.3 2.9 3 0 0 3 3 3 1 CBF/Mak21 family Cyclin_C PF02984.19 EFX05867.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.8 1 0 0 1 1 1 0 Cyclin, C-terminal domain Ligase_CoA PF00549.19 EFX05868.1 - 1.4e-33 115.9 0.3 1.8e-15 57.1 0.0 2.5 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.19 EFX05868.1 - 1.4e-14 54.5 0.1 4.3e-14 53.0 0.1 1.8 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 EFX05868.1 - 8.2e-10 38.6 0.1 2.8e-06 27.2 0.0 3.4 2 1 1 3 3 3 2 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_2 PF08442.10 EFX05868.1 - 0.12 11.9 0.0 0.38 10.3 0.0 1.8 1 1 0 1 1 1 0 ATP-grasp domain IPK PF03770.16 EFX05869.1 - 1.3e-52 178.6 0.0 2.5e-52 177.6 0.0 1.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase Monellin PF09200.10 EFX05869.1 - 0.046 13.6 0.2 0.1 12.5 0.2 1.6 1 0 0 1 1 1 0 Monellin Dus PF01207.17 EFX05871.1 - 5.7e-36 124.2 0.0 7.5e-25 87.7 0.0 2.9 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EFX05871.1 - 5.7 7.0 9.6 11 6.1 1.2 2.6 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FNIP_N PF14636.6 EFX05872.1 - 3.4e-41 141.8 0.0 3.4e-41 141.8 0.0 4.6 3 1 1 5 5 5 1 Folliculin-interacting protein N-terminus RNA_pol_N PF01194.17 EFX05873.1 - 2.1e-30 104.8 1.9 2.5e-30 104.5 1.9 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 EFX05873.1 - 0.059 13.6 0.4 0.094 13.0 0.4 1.4 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Aminotran_1_2 PF00155.21 EFX05874.1 - 2.3e-62 211.3 0.0 2.7e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DAO PF01266.24 EFX05875.1 - 5.1e-35 121.7 3.7 5.8e-35 121.5 3.7 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFX05875.1 - 0.00073 19.7 0.2 0.0017 18.5 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX05875.1 - 0.005 16.1 0.0 0.0077 15.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX05875.1 - 0.0085 15.2 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EFX05875.1 - 0.011 16.3 0.1 0.023 15.2 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX05875.1 - 0.014 14.7 0.1 0.025 13.8 0.1 1.4 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 EFX05875.1 - 0.1 12.2 0.1 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 EFX05875.1 - 0.12 11.5 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A LRRFIP PF09738.9 EFX05878.1 - 0.077 12.5 1.6 0.12 11.8 1.6 1.2 1 0 0 1 1 1 0 LRRFIP family TFCD_C PF12612.8 EFX05880.1 - 9.4e-16 58.2 0.0 6.9e-15 55.4 0.0 2.4 1 1 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 EFX05880.1 - 0.49 10.8 0.0 0.49 10.8 0.0 6.7 7 0 0 7 7 7 0 HEAT repeat AhpC-TSA_2 PF13911.6 EFX05881.1 - 2.4e-10 40.6 0.0 4.2e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EFX05881.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Acid_PPase PF12689.7 EFX05882.1 - 4.2e-54 182.9 0.0 6.3e-54 182.3 0.0 1.3 1 0 0 1 1 1 1 Acid Phosphatase Glyco_trans_4_4 PF13579.6 EFX05882.1 - 0.0074 16.7 0.5 0.0074 16.7 0.5 2.1 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain HAD PF12710.7 EFX05882.1 - 0.31 11.4 2.6 21 5.5 1.4 3.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 EFX05883.1 - 4.4e-19 68.6 65.0 1.9e-11 43.5 26.7 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFX05883.1 - 0.00018 20.2 39.4 0.0012 17.5 8.5 3.2 2 1 1 3 3 3 2 MFS/sugar transport protein SBF_like PF13593.6 EFX05884.1 - 8.7e-87 291.3 14.2 1e-86 291.1 14.2 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 EFX05884.1 - 2.4e-09 37.2 6.3 2.4e-09 37.2 6.3 1.6 2 0 0 2 2 2 1 Sodium Bile acid symporter family Serglycin PF04360.12 EFX05885.1 - 0.00025 21.0 2.1 0.00025 21.0 2.1 3.4 3 0 0 3 3 3 1 Serglycin F-box PF00646.33 EFX05886.1 - 0.00076 19.3 0.0 0.00076 19.3 0.0 2.6 2 1 0 2 2 2 1 F-box domain PRANC PF09372.10 EFX05886.1 - 0.012 16.0 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 PRANC domain F-box-like PF12937.7 EFX05886.1 - 0.043 13.7 0.0 0.043 13.7 0.0 3.0 3 1 0 3 3 3 0 F-box-like F-box_4 PF15966.5 EFX05886.1 - 0.057 13.3 1.0 0.27 11.1 0.1 2.3 1 1 0 2 2 2 0 F-box MFS_1 PF07690.16 EFX05887.1 - 1.5e-16 60.3 44.5 2.4e-08 33.3 25.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX05887.1 - 7.1e-14 51.5 19.3 8.1e-13 48.0 19.0 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter DUF4078 PF13300.6 EFX05888.1 - 2.2e-15 56.7 3.1 2.2e-15 56.7 3.1 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) DUF903 PF06004.12 EFX05888.1 - 0.046 13.6 0.9 0.11 12.4 0.9 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) Cwf_Cwc_15 PF04889.12 EFX05888.1 - 1.6 8.4 18.1 0.062 13.0 11.1 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Aldedh PF00171.22 EFX05888.1 - 7.8 4.9 6.4 13 4.2 6.4 1.3 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Ion_trans PF00520.31 EFX05889.1 - 9.4e-08 31.6 23.1 1.2e-06 28.0 23.1 2.3 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 EFX05889.1 - 5.1e-06 25.4 12.3 0.0015 17.3 1.1 2.2 1 1 1 2 2 2 2 Polycystin cation channel Pinin_SDK_N PF04697.13 EFX05889.1 - 0.0047 17.6 0.1 0.029 15.0 0.1 2.1 1 1 0 1 1 1 1 pinin/SDK conserved region PNTB_4TM PF12769.7 EFX05889.1 - 0.028 14.9 1.2 0.059 13.8 0.2 2.1 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Peptidase_M28 PF04389.17 EFX05890.1 - 6.1e-31 107.6 0.1 8.4e-31 107.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFX05890.1 - 3.6e-06 26.8 0.0 6.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Tam41_Mmp37 PF09139.11 EFX05891.1 - 2e-125 418.5 0.0 2.5e-125 418.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial DUF21 PF01595.20 EFX05892.1 - 5.3e-33 114.2 0.0 9.7e-33 113.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain IF-2B PF01008.17 EFX05892.1 - 2.7e-24 85.9 0.0 5.6e-24 84.8 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.28 EFX05892.1 - 1.7e-12 47.5 0.0 4.7e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain CBS PF00571.28 EFX05892.1 - 0.00016 22.1 0.3 0.043 14.2 0.0 3.2 3 0 0 3 3 3 1 CBS domain E1_dh PF00676.20 EFX05893.1 - 2.6e-86 289.3 0.0 3e-86 289.1 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EFX05893.1 - 0.0014 18.4 0.1 0.014 15.2 0.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF3106 PF11304.8 EFX05893.1 - 0.096 13.2 1.5 0.17 12.4 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) DXP_synthase_N PF13292.6 EFX05893.1 - 0.15 11.2 0.0 0.49 9.6 0.0 1.7 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase HEAT PF02985.22 EFX05894.1 - 0.07 13.4 5.4 1.3 9.5 0.0 4.9 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 EFX05894.1 - 0.17 12.4 2.7 30 5.2 0.0 4.2 4 0 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 EFX05894.1 - 1.8 8.7 0.0 1.8 8.7 0.0 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Nop25 PF09805.9 EFX05895.1 - 3.9e-39 134.2 16.0 3.9e-39 134.2 16.0 2.5 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) DDE_Tnp_1_6 PF13751.6 EFX05895.1 - 6.6 7.0 9.6 0.23 11.7 2.4 2.0 2 0 0 2 2 2 0 Transposase DDE domain Reticulon PF02453.17 EFX05896.1 - 8.3e-33 113.6 3.0 1.1e-32 113.1 3.0 1.2 1 0 0 1 1 1 1 Reticulon DD_K PF12121.8 EFX05896.1 - 0.55 10.4 3.3 1.2 9.3 3.3 1.5 1 0 0 1 1 1 0 Dermaseptin DUF1043 PF06295.12 EFX05896.1 - 1.7 8.6 5.4 0.26 11.3 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) AAA_lid_2 PF17863.1 EFX05897.1 - 8.6e-05 22.3 0.1 0.00039 20.2 0.1 2.1 2 0 0 2 2 2 1 AAA lid domain AAA_3 PF07726.11 EFX05897.1 - 0.066 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KH_2 PF07650.17 EFX05897.1 - 0.082 12.7 0.0 0.2 11.5 0.0 1.6 2 0 0 2 2 2 0 KH domain Myb_Cef PF11831.8 EFX05898.1 - 9.7e-41 139.9 5.8 9.7e-41 139.9 5.8 3.6 3 2 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EFX05898.1 - 3.1e-23 81.7 2.4 1.8e-11 44.0 0.2 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX05898.1 - 2.7e-21 75.6 4.2 3.4e-14 52.8 0.9 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EFX05898.1 - 0.034 14.2 0.2 0.23 11.5 0.0 2.5 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Aminotran_3 PF00202.21 EFX05899.1 - 4.6e-92 308.8 0.0 6e-92 308.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFX05899.1 - 4.3e-06 26.1 0.0 1.5e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFX05899.1 - 0.00099 18.2 0.0 0.1 11.5 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V HECT PF00632.25 EFX05900.1 - 1.6e-72 244.6 0.0 2.8e-72 243.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HEAT PF02985.22 EFX05900.1 - 3.6e-06 26.8 0.7 0.022 15.0 0.1 4.4 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 EFX05900.1 - 0.00043 20.7 0.6 0.029 14.9 0.1 3.8 5 0 0 5 5 5 1 HEAT-like repeat Arm PF00514.23 EFX05900.1 - 0.00083 19.3 6.3 0.071 13.2 0.1 5.2 5 1 1 6 6 6 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFX05900.1 - 0.062 13.7 0.1 17 5.9 0.0 3.4 1 1 2 3 3 3 0 HEAT repeats V-ATPase_H_C PF11698.8 EFX05900.1 - 0.26 11.4 1.3 29 4.8 0.1 4.0 3 1 1 4 4 4 0 V-ATPase subunit H RRN3 PF05327.11 EFX05900.1 - 0.5 8.8 2.0 1.1 7.7 2.0 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Roughex PF06020.11 EFX05900.1 - 0.58 9.2 9.3 1.6 7.7 9.3 1.8 1 0 0 1 1 1 0 Drosophila roughex protein BUD22 PF09073.10 EFX05900.1 - 0.72 9.1 13.6 1.8 7.8 10.3 2.2 2 0 0 2 2 2 0 BUD22 Adaptin_N PF01602.20 EFX05900.1 - 6.7 5.1 8.5 0.41 9.2 0.0 2.9 4 0 0 4 4 4 0 Adaptin N terminal region Ribosomal_L1 PF00687.21 EFX05901.1 - 8.6e-59 198.7 0.5 8.6e-59 198.7 0.5 1.8 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family DUF724 PF05266.14 EFX05903.1 - 0.00032 20.6 0.1 0.00064 19.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Filament PF00038.21 EFX05903.1 - 0.033 13.8 0.1 0.086 12.4 0.1 1.6 1 0 0 1 1 1 0 Intermediate filament protein SOAR PF16533.5 EFX05903.1 - 0.19 11.7 1.3 0.34 10.9 0.5 1.8 2 0 0 2 2 2 0 STIM1 Orai1-activating region Spc7 PF08317.11 EFX05903.1 - 0.29 10.0 1.5 0.66 8.8 1.5 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 EFX05903.1 - 2.7 8.7 8.1 0.32 11.6 0.9 3.2 4 0 0 4 4 4 0 SlyX Abhydrolase_1 PF00561.20 EFX05905.1 - 2.2e-38 132.4 0.0 2.7e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX05905.1 - 0.025 13.8 0.0 0.083 12.1 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFX05905.1 - 0.1 13.2 8.8 0.17 12.5 8.8 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Methyltransf_23 PF13489.6 EFX05906.1 - 1.9e-18 66.8 0.0 1.5e-17 64.0 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX05906.1 - 7.7e-16 58.6 0.0 2e-13 50.9 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05906.1 - 1.4e-14 54.5 0.0 5.2e-13 49.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05906.1 - 1.4e-10 41.8 0.0 5.2e-08 33.5 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05906.1 - 2.2e-08 34.0 0.0 0.0094 15.8 0.0 3.1 2 1 1 3 3 3 2 Methyltransferase domain Ubie_methyltran PF01209.18 EFX05906.1 - 4e-07 29.6 0.0 2.1e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFX05906.1 - 0.0015 18.0 0.0 0.008 15.7 0.0 2.1 3 0 0 3 3 3 1 Putative methyltransferase MTS PF05175.14 EFX05906.1 - 0.0076 15.8 0.0 0.037 13.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_8 PF05148.15 EFX05906.1 - 0.026 14.4 0.0 0.06 13.2 0.0 1.7 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_16 PF10294.9 EFX05906.1 - 0.042 13.6 0.0 0.086 12.6 0.0 1.4 2 0 0 2 2 2 0 Lysine methyltransferase HTH_ABP1_N PF18107.1 EFX05907.1 - 2.6e-25 87.9 1.7 8.7e-25 86.2 1.7 1.9 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 EFX05907.1 - 1.2e-17 63.7 2.6 3.5e-17 62.2 0.2 2.6 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain SUIM_assoc PF16619.5 EFX05907.1 - 0.012 15.6 0.1 0.012 15.6 0.1 2.6 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 HTH_32 PF13565.6 EFX05907.1 - 0.021 15.4 1.9 0.36 11.5 1.1 2.7 2 0 0 2 2 2 0 Homeodomain-like domain TFIIA PF03153.13 EFX05907.1 - 0.11 12.5 13.4 0.015 15.4 9.4 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spore_YhcN_YlaJ PF09580.10 EFX05907.1 - 1.1 9.3 4.9 1 9.4 3.1 1.8 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Spt20 PF12090.8 EFX05907.1 - 1.5 8.4 6.5 2.7 7.5 6.5 1.4 1 0 0 1 1 1 0 Spt20 family Med15 PF09606.10 EFX05907.1 - 3.7 6.1 24.4 0.016 13.9 15.3 1.6 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4259 PF14078.6 EFX05907.1 - 4.7 7.9 12.4 11 6.8 2.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) GTP1_OBG PF01018.22 EFX05907.1 - 9.3 5.8 7.9 3.3 7.3 3.0 2.4 3 0 0 3 3 3 0 GTP1/OBG LysM PF01476.20 EFX05908.1 - 1.7e-13 50.4 1.3 0.0021 18.1 0.1 4.8 5 0 0 5 5 5 4 LysM domain HTH_Tnp_1 PF01527.20 EFX05908.1 - 1.2e-07 32.0 0.0 0.31 11.4 0.0 3.6 4 0 0 4 4 4 3 Transposase Mad3_BUB1_I PF08311.12 EFX05909.1 - 4.4e-43 146.2 0.9 1.6e-42 144.4 0.2 2.3 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EFX05909.1 - 4.5e-08 32.8 0.0 1.3e-07 31.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.11 EFX05909.1 - 1.1e-05 25.5 0.0 3.4e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Mad3/BUB1 homology region 2 Pkinase_Tyr PF07714.17 EFX05909.1 - 0.013 14.8 0.0 0.07 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein tyrosine kinase ADH_N PF08240.12 EFX05910.1 - 2.5e-24 85.3 2.3 4.1e-24 84.6 2.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX05910.1 - 2.4e-10 40.5 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX05910.1 - 0.00082 20.4 0.0 0.0015 19.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX05910.1 - 0.0028 17.2 0.9 0.72 9.3 0.1 3.1 3 0 0 3 3 3 1 Glucose dehydrogenase C-terminus S1-like PF14444.6 EFX05910.1 - 0.015 15.3 0.3 0.37 10.8 0.1 2.5 2 0 0 2 2 2 0 S1-like Glyco_transf_15 PF01793.16 EFX05911.1 - 2.7e-130 434.4 7.3 3.2e-130 434.1 7.3 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Cas_csx3 PF09620.10 EFX05912.1 - 0.057 13.3 0.1 0.34 10.8 0.0 2.0 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_csx3) CwsA PF10814.8 EFX05912.1 - 0.065 13.4 0.9 6.7 6.9 0.5 2.1 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA GST_C_2 PF13410.6 EFX05913.1 - 2.1e-10 40.5 0.5 4.4e-08 33.0 0.1 2.3 1 1 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFX05913.1 - 4.7e-10 39.6 0.0 7.3e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFX05913.1 - 1e-08 35.3 0.1 5.5e-08 32.9 0.0 1.9 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFX05913.1 - 1.1e-07 32.1 0.0 2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFX05913.1 - 3e-07 30.7 0.0 5.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFX05913.1 - 2.2e-06 27.9 0.0 3.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFX05913.1 - 0.00088 19.0 0.1 0.0017 18.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain HpcH_HpaI PF03328.14 EFX05914.1 - 1.1e-35 122.8 0.1 1.5e-35 122.4 0.1 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Methyltransf_31 PF13847.6 EFX05914.1 - 0.1 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UQ_con PF00179.26 EFX05915.1 - 4.2e-35 120.4 0.0 4.7e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFX05915.1 - 0.032 13.9 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RNA_pol_Rpb2_6 PF00562.28 EFX05916.1 - 2.3e-122 408.9 0.1 3.7e-122 408.2 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFX05916.1 - 1.2e-55 188.2 0.0 1.8e-55 187.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EFX05916.1 - 1e-31 109.2 0.3 2.3e-31 108.1 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EFX05916.1 - 2.6e-24 85.9 0.4 6.1e-23 81.4 0.4 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EFX05916.1 - 8.2e-22 77.3 0.2 2e-21 76.0 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EFX05916.1 - 1.7e-20 72.9 0.0 3.5e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EFX05916.1 - 7.8e-11 42.4 0.1 3e-10 40.5 0.1 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF202 PF02656.15 EFX05917.1 - 7e-06 26.4 3.4 3.3e-05 24.2 2.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Na_Ca_ex PF01699.24 EFX05918.1 - 4.3e-44 150.1 40.8 1.7e-23 83.3 16.5 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Vps52 PF04129.12 EFX05919.1 - 1e-122 410.5 0.0 1.3e-122 410.1 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EFX05919.1 - 0.004 15.6 0.2 0.004 15.6 0.2 1.8 2 0 0 2 2 2 1 Exocyst complex component Sec3 Metallophos PF00149.28 EFX05920.1 - 2e-35 123.1 0.5 2.7e-35 122.7 0.5 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFX05920.1 - 0.0085 16.5 0.3 0.023 15.1 0.3 1.7 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 EFX05920.1 - 0.11 12.7 0.0 0.16 12.1 0.0 1.4 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain GFA PF04828.14 EFX05921.1 - 8.2e-11 42.1 0.0 1e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DUF3128 PF11326.8 EFX05922.1 - 2e-25 89.0 2.5 3.3e-25 88.2 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Tropomyosin_1 PF12718.7 EFX05923.1 - 8.8e-52 175.1 28.9 1e-51 174.8 28.9 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EFX05923.1 - 5.1e-07 29.3 28.9 0.00068 19.1 7.3 3.0 1 1 2 3 3 3 3 Tropomyosin ATG16 PF08614.11 EFX05923.1 - 0.00021 21.6 29.3 0.22 11.7 17.7 2.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) KLRAQ PF10205.9 EFX05923.1 - 0.00074 19.7 17.9 0.0061 16.8 4.1 3.1 1 1 2 3 3 3 2 Predicted coiled-coil domain-containing protein DUF4200 PF13863.6 EFX05923.1 - 0.0012 19.2 29.4 0.0087 16.5 11.6 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.9 EFX05923.1 - 0.0012 18.8 5.1 0.0012 18.8 5.1 2.8 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.11 EFX05923.1 - 0.0022 16.9 27.9 0.0093 14.9 14.0 2.0 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like TACC_C PF05010.14 EFX05923.1 - 0.0043 16.9 19.9 0.15 11.8 19.4 2.2 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Surfac_D-trimer PF09006.11 EFX05923.1 - 0.0055 16.6 0.0 0.021 14.7 0.0 2.1 2 0 0 2 2 1 1 Lung surfactant protein D coiled-coil trimerisation GAS PF13851.6 EFX05923.1 - 0.008 15.5 26.6 0.19 11.1 11.0 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EFX05923.1 - 0.0089 14.9 29.2 0.024 13.5 16.0 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein Lebercilin PF15619.6 EFX05923.1 - 0.018 14.7 31.4 0.46 10.1 15.7 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.8 EFX05923.1 - 0.025 14.7 27.2 0.038 14.1 7.7 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 EFX05923.1 - 0.061 13.4 27.8 0.31 11.1 11.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 EFX05923.1 - 0.073 13.5 21.8 0.13 12.7 21.8 1.4 1 0 0 1 1 1 0 Fez1 Cortex-I_coil PF09304.10 EFX05923.1 - 0.085 13.1 19.7 3.4 7.9 4.7 3.3 1 1 2 3 3 3 0 Cortexillin I, coiled coil HMMR_C PF15908.5 EFX05923.1 - 0.11 12.8 18.1 0.049 13.9 4.3 2.5 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal APG6_N PF17675.1 EFX05923.1 - 0.12 12.9 36.3 0.24 11.9 20.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 EFX05923.1 - 0.12 12.1 21.3 0.097 12.5 7.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3450 PF11932.8 EFX05923.1 - 0.13 11.5 23.3 0.65 9.3 8.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CENP-K PF11802.8 EFX05923.1 - 0.22 11.1 19.0 0.25 10.9 4.3 2.2 1 1 1 2 2 2 0 Centromere-associated protein K DUF3584 PF12128.8 EFX05923.1 - 0.29 8.6 23.4 0.62 7.5 23.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Lectin_N PF03954.14 EFX05923.1 - 0.39 10.5 12.1 0.52 10.1 2.9 2.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain HrpB7 PF09486.10 EFX05923.1 - 0.5 10.7 16.1 0.43 11.0 14.6 1.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Syntaxin-6_N PF09177.11 EFX05923.1 - 0.54 10.9 15.2 1.4 9.5 4.8 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 EFX05923.1 - 0.85 9.7 12.0 0.35 10.9 1.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Taxilin PF09728.9 EFX05923.1 - 1 8.5 27.8 2 7.5 27.8 1.5 1 1 0 1 1 1 0 Myosin-like coiled-coil protein ERM PF00769.19 EFX05923.1 - 1.1 9.1 34.8 0.15 11.8 16.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family HOOK PF05622.12 EFX05923.1 - 1.3 7.1 25.7 1.8 6.6 25.7 1.1 1 0 0 1 1 1 0 HOOK protein BRE1 PF08647.11 EFX05923.1 - 1.4 9.1 28.5 3.5 7.8 13.6 2.5 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase TMF_TATA_bd PF12325.8 EFX05923.1 - 1.5 9.0 23.1 20 5.4 14.6 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding FlaC_arch PF05377.11 EFX05923.1 - 1.5 9.2 17.5 13 6.3 2.3 4.4 1 1 4 5 5 5 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 EFX05923.1 - 1.7 8.8 12.0 2.8 8.1 2.4 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family KELK PF15796.5 EFX05923.1 - 2.2 8.8 28.7 0.42 11.1 2.5 3.4 2 2 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Cep57_MT_bd PF06657.13 EFX05923.1 - 2.3 8.7 18.3 1.2 9.7 1.8 3.5 2 2 2 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Atg14 PF10186.9 EFX05923.1 - 2.4 7.2 18.7 0.74 8.8 9.5 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec34 PF04136.15 EFX05923.1 - 2.9 7.8 14.8 0.53 10.1 2.7 2.2 1 1 1 2 2 2 0 Sec34-like family Laminin_II PF06009.12 EFX05923.1 - 2.9 7.9 14.5 0.51 10.4 4.2 2.7 1 1 1 2 2 2 0 Laminin Domain II Fmp27_WPPW PF10359.9 EFX05923.1 - 3.5 6.4 19.8 0.093 11.6 7.3 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain LPP PF04728.13 EFX05923.1 - 4 7.9 7.7 17 5.9 0.1 3.6 3 1 1 4 4 4 0 Lipoprotein leucine-zipper Spc29 PF17082.5 EFX05923.1 - 4.1 7.2 13.0 14 5.4 2.3 2.8 1 1 1 2 2 2 0 Spindle Pole Component 29 Seryl_tRNA_N PF02403.22 EFX05923.1 - 4.5 7.5 24.3 1.6 9.0 0.4 3.0 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Jnk-SapK_ap_N PF09744.9 EFX05923.1 - 4.5 7.5 29.4 0.66 10.2 15.5 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 EFX05923.1 - 4.6 6.5 20.7 9.4 5.5 20.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DHR10 PF18595.1 EFX05923.1 - 4.6 7.3 33.4 12 5.9 22.7 2.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain KASH_CCD PF14662.6 EFX05923.1 - 5.8 6.7 28.7 5.8 6.7 10.6 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.12 EFX05923.1 - 6.1 7.3 24.7 5.8 7.4 9.3 3.1 1 1 2 3 3 3 0 Centromere protein H (CENP-H) FUSC PF04632.12 EFX05923.1 - 9.3 4.7 7.0 10 4.5 7.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GDP_Man_Dehyd PF16363.5 EFX05924.1 - 1.1e-49 169.6 0.0 6.1e-49 167.2 0.0 1.8 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFX05924.1 - 4.8e-40 137.5 0.7 2.4e-39 135.2 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFX05924.1 - 5.3e-14 52.0 0.0 2.6e-13 49.7 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFX05924.1 - 5.5e-14 52.0 0.4 9.9e-14 51.1 0.0 1.6 1 1 1 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EFX05924.1 - 1.1e-10 41.2 0.0 1.6e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EFX05924.1 - 3e-09 36.3 0.4 6e-09 35.3 0.0 1.6 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Zn_clus PF00172.18 EFX05925.1 - 2.9e-07 30.5 6.2 5.4e-07 29.6 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF413 PF04219.12 EFX05925.1 - 0.052 13.6 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF DUF3459 PF11941.8 EFX05925.1 - 0.073 13.4 2.4 0.22 11.9 1.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3459) FAD_binding_1 PF00667.20 EFX05927.1 - 5.6e-64 215.7 0.0 4.5e-63 212.8 0.0 2.4 3 0 0 3 3 3 1 FAD binding domain NAD_binding_1 PF00175.21 EFX05927.1 - 5.3e-10 39.9 0.0 2.1e-09 38.0 0.0 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 EFX05927.1 - 9.6e-07 29.1 0.2 2.9e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II POR PF01558.18 EFX05927.1 - 5.7e-06 26.5 0.0 1.1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase POR_N PF01855.19 EFX05927.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg DUF2213 PF09979.9 EFX05927.1 - 0.16 12.0 0.1 3.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2213) RRM_1 PF00076.22 EFX05928.1 - 1.3e-43 146.7 0.4 1.3e-21 76.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EFX05928.1 - 6e-24 85.0 0.6 2e-23 83.3 0.1 2.2 2 0 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_3 PF08777.11 EFX05928.1 - 0.00061 19.8 0.3 0.0088 16.1 0.0 2.8 3 1 0 3 3 3 1 RNA binding motif RRM_occluded PF16842.5 EFX05928.1 - 0.00075 19.3 0.0 0.13 12.2 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EFX05928.1 - 0.0071 16.6 0.1 0.12 12.5 0.1 3.1 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EFX05928.1 - 0.055 13.6 0.0 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif Bromodomain PF00439.25 EFX05929.1 - 1.1e-15 57.4 0.0 2.7e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Bromodomain BTB PF00651.31 EFX05929.1 - 0.00081 19.6 0.0 0.0016 18.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain PQ-loop PF04193.14 EFX05930.1 - 1.4e-21 76.0 10.4 1.4e-12 47.2 0.2 3.0 3 1 0 3 3 3 2 PQ loop repeat YlaC PF10777.9 EFX05930.1 - 0.018 14.9 0.9 0.062 13.1 0.1 2.2 2 0 0 2 2 2 0 Inner membrane protein YlaC DUF2070 PF09843.9 EFX05930.1 - 0.06 11.6 0.7 0.09 11.0 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PRA1 PF03208.19 EFX05930.1 - 0.19 11.3 2.2 0.54 9.9 2.2 1.8 1 0 0 1 1 1 0 PRA1 family protein DUF4131 PF13567.6 EFX05930.1 - 2.4 7.8 8.1 1.1 8.8 0.4 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2304 PF10066.9 EFX05930.1 - 8.8 6.6 9.7 2 8.6 0.5 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) RNA12 PF10443.9 EFX05931.1 - 2.8e-155 517.4 0.0 1e-124 416.7 0.1 2.1 2 0 0 2 2 2 2 RNA12 protein RRM_1 PF00076.22 EFX05931.1 - 7.6e-05 22.4 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 EFX05931.1 - 0.00062 19.8 0.0 0.0061 16.5 0.0 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFX05931.1 - 0.0014 19.0 0.1 0.0014 19.0 0.1 3.0 3 1 1 4 4 4 1 AAA ATPase domain DUF2487 PF10673.9 EFX05931.1 - 0.017 15.1 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) baeRF_family10 PF18854.1 EFX05931.1 - 0.027 14.7 0.2 0.074 13.3 0.2 1.8 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 TLD PF07534.16 EFX05932.1 - 0.0052 17.0 0.0 0.0068 16.6 0.0 1.2 1 0 0 1 1 1 1 TLD dCMP_cyt_deam_2 PF08211.12 EFX05932.1 - 0.17 12.1 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DnaJ PF00226.31 EFX05933.1 - 1.6e-24 85.8 0.2 1.6e-24 85.8 0.2 1.9 2 0 0 2 2 2 1 DnaJ domain TFIIA PF03153.13 EFX05933.1 - 0.00021 21.4 13.0 0.00026 21.1 13.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MRVI1 PF05781.12 EFX05933.1 - 0.29 9.8 2.3 0.39 9.4 2.3 1.3 1 0 0 1 1 1 0 MRVI1 protein PAT1 PF09770.9 EFX05933.1 - 0.37 9.0 11.2 0.4 8.9 11.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 EFX05933.1 - 0.4 10.2 9.3 0.59 9.6 9.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 EFX05933.1 - 1.1 9.3 4.5 1.4 8.9 4.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 EFX05933.1 - 4 7.0 21.1 7.3 6.1 21.1 1.4 1 0 0 1 1 1 0 Spt20 family Pro_isomerase PF00160.21 EFX05934.1 - 9.9e-49 165.6 0.0 1.5e-48 165.1 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 EFX05934.1 - 0.003 17.6 0.0 0.0067 16.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 EFX05934.1 - 0.082 13.1 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 U-box domain Abhydrolase_3 PF07859.13 EFX05935.1 - 1.1e-09 38.5 0.0 1.3e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold BIR PF00653.21 EFX05936.1 - 6.1e-47 158.2 5.1 1.1e-22 80.5 2.2 2.4 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain CCP_MauG PF03150.14 EFX05936.1 - 0.4 11.3 3.9 5.4 7.7 3.9 2.8 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase WD40 PF00400.32 EFX05937.1 - 2.1e-19 69.5 19.2 0.00013 22.7 0.5 6.9 6 2 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05937.1 - 4.1e-13 49.4 4.3 0.00015 22.0 0.0 4.2 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EFX05937.1 - 0.00044 20.2 9.1 0.16 11.9 0.2 3.9 2 2 1 3 3 3 2 Transcription factor IIIC subunit delta N-term Nup160 PF11715.8 EFX05937.1 - 0.011 14.4 1.2 0.97 8.0 0.2 2.5 1 1 0 2 2 2 0 Nucleoporin Nup120/160 TAF4 PF05236.14 EFX05938.1 - 1.5e-27 97.0 0.0 5.2e-23 82.2 0.0 2.7 2 1 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family Keratin_2_head PF16208.5 EFX05938.1 - 1.4 9.0 25.8 3.5 7.8 25.8 1.6 1 0 0 1 1 1 0 Keratin type II head PLAC8 PF04749.17 EFX05939.1 - 1.1e-22 80.9 14.5 1.4e-22 80.5 14.5 1.2 1 0 0 1 1 1 1 PLAC8 family DIT1_PvcA PF05141.12 EFX05940.1 - 3.2e-83 279.4 0.0 4.6e-83 278.9 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein AMP-binding PF00501.28 EFX05940.1 - 3.6e-11 42.3 0.3 9.6e-08 31.0 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 EFX05940.1 - 1.2e-07 32.0 0.0 3.6e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Transferase PF02458.15 EFX05940.1 - 1.3e-05 24.1 0.0 0.0072 15.0 0.0 2.9 3 0 0 3 3 3 2 Transferase family PWI PF01480.17 EFX05941.1 - 7.4e-14 51.8 0.4 1.5e-13 50.8 0.4 1.6 1 0 0 1 1 1 1 PWI domain RGS PF00615.19 EFX05942.1 - 8.7e-09 35.7 0.0 1.5e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PAS_9 PF13426.7 EFX05942.1 - 2.6e-05 24.4 0.0 0.0031 17.7 0.0 3.3 3 0 0 3 3 3 1 PAS domain PIR PF00399.19 EFX05943.1 - 0.0022 17.5 2.7 0.0022 17.5 2.7 6.2 4 1 0 4 4 4 3 Yeast PIR protein repeat LIM PF00412.22 EFX05944.1 - 4.6e-22 78.0 14.8 2e-09 37.5 3.4 3.9 4 0 0 4 4 4 3 LIM domain DUF2321 PF10083.9 EFX05944.1 - 0.022 14.4 0.1 0.022 14.4 0.1 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) Sec3_C PF09763.9 EFX05944.1 - 0.37 9.1 0.1 0.64 8.3 0.1 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 TNFR_c6 PF00020.18 EFX05944.1 - 3 8.3 12.1 2.7 8.4 0.1 4.1 4 0 0 4 4 4 0 TNFR/NGFR cysteine-rich region DZR PF12773.7 EFX05944.1 - 7.8 6.6 22.2 1.4 9.0 8.4 3.9 2 1 2 4 4 4 0 Double zinc ribbon Band_7 PF01145.25 EFX05945.1 - 7.3e-32 110.8 0.6 1.4e-31 109.9 0.6 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EFX05945.1 - 6.5e-21 74.2 1.8 1.6e-20 72.9 1.8 1.7 1 0 0 1 1 1 1 C-terminal region of band_7 DLH PF01738.18 EFX05945.1 - 1.1e-17 64.4 0.0 3.6e-16 59.4 0.0 2.9 2 1 0 2 2 2 1 Dienelactone hydrolase family Methyltransf_25 PF13649.6 EFX05945.1 - 2.8e-15 56.8 0.1 4.8e-14 52.8 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05945.1 - 7.2e-14 52.2 0.0 4.1e-13 49.8 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX05945.1 - 1.1e-07 31.8 0.0 2.3e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05945.1 - 4.3e-06 27.4 0.0 1.8e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX05945.1 - 0.00012 21.5 0.0 0.00049 19.5 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFX05945.1 - 0.0004 20.2 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Pox_A11 PF05061.13 EFX05945.1 - 0.043 13.1 0.4 0.071 12.4 0.4 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein MTS PF05175.14 EFX05945.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase small domain DUF3597 PF12200.8 EFX05946.1 - 2.3 8.8 8.0 2.9 8.4 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Glyco_transf_22 PF03901.17 EFX05947.1 - 1.4e-84 284.7 17.4 1.7e-84 284.5 17.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family UvrD-helicase PF00580.21 EFX05948.1 - 4.4e-60 203.8 0.0 1.1e-58 199.3 0.0 2.2 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EFX05948.1 - 5e-60 203.7 0.0 1.2e-59 202.4 0.0 1.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EFX05948.1 - 2.5e-29 102.5 0.0 9.1e-29 100.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EFX05948.1 - 4.7e-13 48.8 0.0 1e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EFX05948.1 - 2.6e-09 37.1 7.3 1.4e-05 24.9 0.1 3.1 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EFX05948.1 - 5.7e-06 26.2 0.0 0.011 15.5 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 EFX05948.1 - 0.00034 20.3 0.1 0.0016 18.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFX05948.1 - 0.68 9.2 2.3 9.9 5.4 0.0 2.9 2 1 1 3 3 3 0 Zeta toxin Abhydrolase_1 PF00561.20 EFX05950.1 - 4.1e-13 49.6 0.2 2.1e-11 43.9 0.2 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX05950.1 - 8.5e-09 35.0 0.0 1.3e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 EFX05950.1 - 0.054 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Ribosomal_L36 PF00444.18 EFX05951.1 - 4.4e-20 71.6 11.5 9.1e-20 70.6 11.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L36 DUF4636 PF15468.6 EFX05951.1 - 0.2 11.4 1.3 0.23 11.1 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) MDMPI_N PF11716.8 EFX05952.1 - 0.021 15.5 0.6 0.12 13.1 0.1 2.3 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain Pinin_SDK_N PF04697.13 EFX05952.1 - 3 8.5 5.6 0.81 10.3 0.1 2.3 2 0 0 2 2 2 0 pinin/SDK conserved region Ubie_methyltran PF01209.18 EFX05953.1 - 8.9e-64 215.0 0.0 1.2e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFX05953.1 - 5.8e-15 55.8 0.0 4.1e-14 53.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX05953.1 - 4.8e-11 43.2 0.0 5.4e-10 39.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX05953.1 - 1.9e-10 41.3 0.0 3.3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX05953.1 - 4.8e-09 36.2 0.0 6.9e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFX05953.1 - 5.1e-06 26.4 0.0 6.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX05953.1 - 0.024 14.2 0.0 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_8 PF05148.15 EFX05953.1 - 0.074 12.9 0.0 0.25 11.2 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase AF-4 PF05110.13 EFX05954.1 - 0.0022 16.2 10.8 0.0022 16.2 10.8 1.4 2 0 0 2 2 2 1 AF-4 proto-oncoprotein Apt1 PF10351.9 EFX05954.1 - 0.054 12.3 0.5 0.075 11.9 0.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sugar_tr PF00083.24 EFX05955.1 - 5.2e-50 170.6 18.0 7e-50 170.2 18.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFX05955.1 - 8.7e-18 64.4 31.1 8.7e-18 64.4 31.1 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily WD40 PF00400.32 EFX05956.1 - 7.9e-30 102.5 5.3 2.3e-07 31.4 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05956.1 - 3.7e-12 46.4 0.0 0.018 15.3 0.0 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX05956.1 - 0.14 10.7 2.3 4.3 5.9 0.0 2.9 1 1 0 3 3 3 0 Nucleoporin Nup120/160 DHHA2 PF02833.14 EFX05957.1 - 1.3e-32 112.9 0.0 1.8e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EFX05957.1 - 3.7e-11 43.1 0.0 7.7e-11 42.1 0.0 1.5 1 1 0 1 1 1 1 DHH family NAD_binding_2 PF03446.15 EFX05960.1 - 9.7e-37 126.6 1.6 1.9e-36 125.6 1.6 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFX05960.1 - 1.7e-29 102.5 1.4 1.9e-29 102.4 0.2 1.7 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase OCD_Mu_crystall PF02423.15 EFX05960.1 - 3.2e-07 29.6 0.0 5.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 EFX05960.1 - 1.7e-06 28.5 1.8 2.5e-05 24.8 0.1 2.3 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 EFX05960.1 - 8.4e-05 23.4 0.1 0.00018 22.3 0.1 1.6 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TrkA_N PF02254.18 EFX05960.1 - 0.00084 19.6 0.8 0.0056 16.9 0.0 2.3 2 0 0 2 2 2 1 TrkA-N domain 3HCDH_N PF02737.18 EFX05960.1 - 0.0017 18.3 2.9 1.3 8.9 0.0 2.9 2 1 1 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EFX05960.1 - 0.0037 17.3 0.0 0.0075 16.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ECH_1 PF00378.20 EFX05960.1 - 0.0079 15.5 4.2 0.013 14.9 0.2 2.7 3 0 0 3 3 3 1 Enoyl-CoA hydratase/isomerase NAD_Gly3P_dh_N PF01210.23 EFX05960.1 - 0.23 11.4 3.9 0.24 11.4 0.2 2.5 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rad4 PF03835.15 EFX05961.1 - 6.4e-27 94.0 0.4 1.4e-26 93.0 0.0 1.8 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EFX05961.1 - 6.3e-25 87.4 0.1 1.1e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EFX05961.1 - 1.8e-19 69.3 0.0 3.4e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EFX05961.1 - 6.9e-18 65.4 11.7 2.9e-17 63.4 0.2 4.0 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EFX05961.1 - 0.00024 21.5 0.4 0.0026 18.2 0.3 2.8 2 1 0 2 2 2 1 Transglutaminase-like superfamily YL1 PF05764.13 EFX05961.1 - 0.0051 17.0 1.8 0.0051 17.0 1.8 2.6 3 0 0 3 3 3 1 YL1 nuclear protein BSP_II PF05432.11 EFX05961.1 - 6.9 6.3 8.8 0.25 11.0 1.6 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Pex14_N PF04695.13 EFX05961.1 - 8.6 7.0 12.6 1.3 9.7 7.0 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mon1 PF03164.14 EFX05962.1 - 1.7e-149 498.3 0.0 2.1e-149 498.0 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Brix PF04427.18 EFX05963.1 - 5.4e-24 85.4 0.0 7.5e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Brix domain RRN3 PF05327.11 EFX05963.1 - 0.0085 14.7 3.8 0.012 14.2 3.8 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 HRI1 PF16815.5 EFX05964.1 - 4.7e-37 127.9 0.1 5.5e-37 127.7 0.1 1.0 1 0 0 1 1 1 1 Protein HRI1 DUF4131 PF13567.6 EFX05964.1 - 0.18 11.5 0.1 0.75 9.4 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) RCC1 PF00415.18 EFX05965.1 - 5e-27 94.3 12.4 5.2e-10 39.8 0.2 6.2 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFX05965.1 - 2.5e-26 90.9 19.7 1.5e-07 31.1 1.1 4.3 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Reg_prop PF07494.11 EFX05965.1 - 0.051 13.8 0.0 17 6.1 0.0 3.1 3 0 0 3 3 3 0 Two component regulator propeller Colicin_Ia PF11504.8 EFX05965.1 - 0.1 12.7 0.2 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 Colicin Ia Fungal_trans PF04082.18 EFX05966.1 - 2.6e-10 39.8 0.0 4.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX05966.1 - 7e-07 29.3 9.6 1.5e-06 28.2 9.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IGPD PF00475.18 EFX05967.1 - 4.4e-59 198.9 0.8 7.7e-59 198.1 0.8 1.4 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Arb1 PF09692.10 EFX05968.1 - 9e-71 239.2 0.3 9.4e-65 219.3 0.0 2.2 1 1 1 2 2 2 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 ABC2_membrane PF01061.24 EFX05969.1 - 6.6e-39 133.5 20.5 6.6e-39 133.5 20.5 2.1 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EFX05969.1 - 2.1e-24 86.6 0.0 3.5e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFX05969.1 - 7e-06 25.4 27.9 7e-06 25.4 27.9 2.3 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFX05969.1 - 2e-05 24.6 0.0 0.15 11.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system PDR_CDR PF06422.12 EFX05969.1 - 0.011 15.7 1.0 0.22 11.5 0.1 3.1 3 0 0 3 3 3 0 CDR ABC transporter AAA_29 PF13555.6 EFX05969.1 - 0.014 15.1 0.1 0.034 13.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EFX05969.1 - 0.033 14.7 0.0 0.083 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFX05969.1 - 0.047 13.6 0.0 0.089 12.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EFX05969.1 - 0.048 13.2 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EFX05969.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EFX05969.1 - 0.1 13.0 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 EFX05969.1 - 0.19 11.8 0.0 0.73 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC2_membrane_2 PF12679.7 EFX05969.1 - 1.1 8.5 18.1 0.02 14.2 6.0 2.4 1 1 1 2 2 2 0 ABC-2 family transporter protein hEGF PF12661.7 EFX05969.1 - 1.2 9.9 19.7 3.6 8.4 7.3 4.5 3 0 0 3 3 3 0 Human growth factor-like EGF EGF_2 PF07974.13 EFX05969.1 - 3.6 8.0 34.1 0.17 12.3 12.5 3.5 3 0 0 3 3 2 0 EGF-like domain HET PF06985.11 EFX05970.1 - 1e-27 97.3 0.7 3.3e-26 92.4 1.6 2.7 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) DUF4693 PF15764.5 EFX05970.1 - 0.038 13.6 0.2 0.071 12.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4693) AP_endonuc_2 PF01261.24 EFX05970.1 - 0.05 13.0 0.1 3.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel PRAS PF15798.5 EFX05970.1 - 0.083 13.5 0.4 0.23 12.1 0.4 1.7 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 DUF1617 PF07761.12 EFX05970.1 - 0.15 12.1 1.1 0.27 11.3 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1617) DUF1338 PF07063.13 EFX05971.1 - 8.3e-107 357.1 0.0 9.6e-107 356.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) ADH_N PF08240.12 EFX05972.1 - 2.5e-31 107.8 0.4 2.5e-31 107.8 0.4 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX05972.1 - 1.8e-24 86.2 0.6 3e-24 85.4 0.6 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFX05972.1 - 1.9e-10 40.6 0.6 3.4e-10 39.8 0.6 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EFX05972.1 - 6.2e-08 33.8 0.1 1.8e-07 32.3 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFX05972.1 - 0.00057 19.2 2.4 0.00099 18.5 2.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EFX05972.1 - 0.0033 16.7 0.1 0.0055 16.0 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TmoB PF06234.12 EFX05972.1 - 0.0065 16.5 1.8 2.1 8.5 0.2 2.9 3 0 0 3 3 3 2 Toluene-4-monooxygenase system protein B (TmoB) UDPG_MGDP_dh_N PF03721.14 EFX05972.1 - 0.011 15.3 0.1 0.022 14.4 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 EFX05972.1 - 0.044 14.5 0.1 0.089 13.5 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain HI0933_like PF03486.14 EFX05972.1 - 0.088 11.5 0.3 0.13 10.9 0.3 1.3 1 0 0 1 1 1 0 HI0933-like protein FtsJ PF01728.19 EFX05972.1 - 0.18 11.9 0.1 0.33 11.1 0.1 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase ProRS-C_1 PF09180.11 EFX05973.1 - 1.1e-20 73.6 0.0 2.4e-20 72.5 0.0 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EFX05973.1 - 4.1e-20 72.5 0.0 1.1e-19 71.1 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFX05973.1 - 3.5e-15 55.9 0.0 9e-15 54.6 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain Actin PF00022.19 EFX05974.1 - 2.8e-136 454.3 0.0 3.2e-136 454.2 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFX05974.1 - 0.00018 20.4 0.0 0.0056 15.5 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein MutL PF13941.6 EFX05974.1 - 0.041 12.5 0.0 0.059 12.0 0.0 1.1 1 0 0 1 1 1 0 MutL protein Ribosom_S12_S23 PF00164.25 EFX05975.1 - 1.4e-30 105.2 0.3 2.2e-30 104.6 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Glyco_hydro_53 PF07745.13 EFX05976.1 - 4.3e-98 328.4 0.0 4.9e-98 328.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 ArfGap PF01412.18 EFX05978.1 - 2.6e-36 124.3 0.5 5.4e-36 123.2 0.5 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF4337 PF14235.6 EFX05978.1 - 2.9 8.0 5.6 0.31 11.2 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Rad51 PF08423.11 EFX05979.1 - 1.2e-35 123.0 0.0 6.6e-33 114.0 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 EFX05979.1 - 0.00037 20.1 0.1 0.00082 19.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EFX05979.1 - 0.00042 19.9 0.1 0.013 14.9 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 EFX05979.1 - 0.0011 18.4 0.0 0.0025 17.2 0.0 1.6 2 0 0 2 2 2 1 KaiC ABC_tran PF00005.27 EFX05979.1 - 0.0064 17.0 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EFX05979.1 - 0.015 15.6 0.0 0.032 14.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EFX05979.1 - 0.1 11.9 0.3 1.2 8.4 0.3 2.0 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain E1-E2_ATPase PF00122.20 EFX05980.1 - 1.5e-49 168.0 0.3 1.5e-49 168.0 0.3 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFX05980.1 - 1.9e-35 123.1 1.0 3.5e-35 122.2 1.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFX05980.1 - 7.1e-21 74.4 3.7 1.9e-12 47.4 0.2 3.9 4 0 0 4 4 4 2 Heavy-metal-associated domain HAD PF12710.7 EFX05980.1 - 3.7e-06 27.5 0.0 1e-05 26.1 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFX05980.1 - 4.7e-05 23.2 0.1 0.00012 21.9 0.1 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Importin_rep_3 PF18806.1 EFX05980.1 - 0.026 14.5 0.0 0.078 13.0 0.0 1.8 1 0 0 1 1 1 0 Importin 13 repeat Thioredoxin PF00085.20 EFX05982.1 - 4.3e-25 87.7 0.1 5e-25 87.5 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EFX05982.1 - 1.2e-07 31.4 0.1 1.3e-07 31.3 0.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFX05982.1 - 7.4e-07 29.6 0.2 1.9e-05 25.0 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EFX05982.1 - 5e-05 23.0 0.1 6.5e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 EFX05982.1 - 0.00016 22.0 0.0 0.00034 20.9 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EFX05982.1 - 0.0002 21.3 0.0 0.00023 21.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EFX05982.1 - 0.00033 20.8 0.0 0.00051 20.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 EFX05982.1 - 0.0017 18.3 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 EFX05982.1 - 0.0022 18.0 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_9 PF14595.6 EFX05982.1 - 0.0031 17.3 0.0 0.0037 17.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.24 EFX05982.1 - 0.029 14.6 0.5 0.086 13.1 0.4 1.8 1 1 0 1 1 1 0 Glutaredoxin NPV_P10 PF05531.12 EFX05983.1 - 1.4 9.4 5.5 1.7 9.2 0.1 3.5 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein CENP-N PF05238.13 EFX05984.1 - 1.2e-134 449.8 0.0 1.3e-134 449.6 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Zn_clus PF00172.18 EFX05985.1 - 8.9e-05 22.5 8.7 0.00016 21.7 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ndc1_Nup PF09531.10 EFX05985.1 - 0.0098 14.6 4.4 0.015 14.1 4.4 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup DUF1631 PF07793.11 EFX05985.1 - 0.1 11.0 5.4 0.14 10.5 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) TFIIA PF03153.13 EFX05985.1 - 0.18 11.7 9.8 0.28 11.1 9.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_C58 PF03543.14 EFX05985.1 - 0.33 10.7 2.3 0.58 9.8 2.3 1.3 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Acetyltransf_1 PF00583.25 EFX05986.1 - 6.2e-08 32.9 0.0 1.4e-07 31.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFX05986.1 - 7.3e-07 29.2 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFX05986.1 - 1.3e-06 28.7 0.0 2.4e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX05986.1 - 3e-05 23.9 0.0 0.0004 20.3 0.0 2.3 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.7 EFX05986.1 - 3.8e-05 23.8 0.0 0.0002 21.5 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFX05986.1 - 0.032 14.3 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Fungal_trans PF04082.18 EFX05987.1 - 3e-25 88.8 0.1 2.4e-24 85.8 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF2433 PF10360.9 EFX05989.1 - 8.7e-49 164.7 0.0 1.9e-48 163.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) TFIIA PF03153.13 EFX05989.1 - 0.047 13.7 6.4 0.076 13.0 6.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 EFX05989.1 - 3.9 6.0 5.4 5 5.7 5.4 1.1 1 0 0 1 1 1 0 Hamartin protein SPX PF03105.19 EFX05989.1 - 7.5 6.4 11.1 4.1 7.2 0.1 2.1 2 0 0 2 2 2 0 SPX domain Actin PF00022.19 EFX05990.1 - 1e-18 67.2 0.0 2.4e-11 42.9 0.0 3.4 3 1 0 3 3 3 3 Actin SUR7 PF06687.12 EFX05991.1 - 5.5e-10 39.2 0.1 8.1e-10 38.7 0.1 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EFX05991.1 - 0.21 11.5 4.7 0.36 10.7 4.7 1.3 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Hist_deacetyl PF00850.19 EFX05992.1 - 4.2e-49 167.7 0.0 7.2e-49 166.9 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain DUF1774 PF08611.10 EFX05992.1 - 2e-30 104.9 4.8 4.5e-30 103.8 4.8 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1774) ACPS PF01648.20 EFX05992.1 - 0.00028 21.0 0.1 0.00084 19.5 0.1 1.9 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EFX05992.1 - 0.023 14.8 0.9 11 6.2 0.1 3.0 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain MFS_1 PF07690.16 EFX05993.1 - 7.6e-27 94.2 23.6 1.9e-22 79.7 2.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF3040 PF11239.8 EFX05993.1 - 0.48 10.7 4.8 8.2 6.8 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Utp21 PF04192.12 EFX05995.1 - 5.9e-77 258.3 0.0 8e-77 257.9 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EFX05995.1 - 6.7e-13 48.9 19.3 0.0062 17.4 0.4 8.1 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX05995.1 - 1.1e-09 38.5 0.0 0.012 15.8 0.0 5.9 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX05995.1 - 0.00012 20.8 0.3 0.71 8.4 0.1 3.8 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFX05995.1 - 0.00014 20.6 0.0 0.022 13.3 0.0 2.4 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 EFX05995.1 - 0.21 10.3 0.0 0.58 8.8 0.0 1.6 1 1 0 1 1 1 0 Nup133 N terminal like Glyco_hydro_18 PF00704.28 EFX05996.1 - 2.7e-58 198.1 0.1 3.7e-58 197.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EFX05996.1 - 3.5e-10 40.2 9.4 3.5e-10 40.2 9.4 3.0 2 1 0 2 2 2 1 Chitin recognition protein Abhydrolase_6 PF12697.7 EFX05997.1 - 7.1e-14 52.9 4.4 1.2e-13 52.2 4.4 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX05997.1 - 8.1e-12 45.3 0.4 1.1e-06 28.4 0.2 2.9 2 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX05997.1 - 6.1e-11 42.0 2.2 5.1e-06 25.9 0.5 2.9 2 1 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EFX05997.1 - 0.0089 15.6 0.1 1.8 8.0 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family UPF0227 PF05728.12 EFX05997.1 - 0.025 14.5 0.0 6 6.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 EFX05997.1 - 0.031 14.0 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 EFX05997.1 - 0.034 13.8 0.3 0.67 9.6 0.1 2.2 2 0 0 2 2 2 0 Putative esterase Abhydrolase_4 PF08386.10 EFX05997.1 - 0.079 13.1 0.0 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 TAP-like protein DUF2048 PF09752.9 EFX05997.1 - 0.53 9.3 1.8 0.85 8.6 1.8 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 p450 PF00067.22 EFX05998.1 - 8e-33 113.9 0.0 3.4e-28 98.6 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 SLD5_C PF16922.5 EFX05999.1 - 7.5e-12 45.3 0.0 1.4e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EFX05999.1 - 4.8e-08 33.4 1.1 1.3e-07 32.1 0.7 2.0 2 1 0 2 2 2 1 GINS complex protein Nup54 PF13874.6 EFX05999.1 - 0.12 12.4 0.1 0.21 11.7 0.1 1.5 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Aminotran_3 PF00202.21 EFX06000.1 - 2.4e-81 273.5 0.0 3.1e-81 273.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III CRAL_TRIO PF00650.20 EFX06001.1 - 2e-23 82.8 0.0 3.3e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFX06001.1 - 8.5e-08 32.3 0.0 1.9e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain TED PF08341.11 EFX06001.1 - 0.15 12.5 0.0 0.75 10.2 0.0 2.1 1 1 0 1 1 1 0 Thioester domain XRN1_DBM PF18245.1 EFX06001.1 - 3.6 7.7 6.5 13 5.9 0.5 2.8 3 0 0 3 3 3 0 5-3 exonuclease XRN1 DCP1-binding motif DUF3818 PF12825.7 EFX06002.1 - 3.2e-51 174.3 0.0 3e-32 112.0 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EFX06002.1 - 9.1e-39 132.4 0.0 1.4e-38 131.8 0.0 1.3 1 0 0 1 1 1 1 PX-associated DUF3944 PF13099.6 EFX06002.1 - 0.019 14.8 0.0 0.057 13.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) GAS2 PF02187.17 EFX06003.1 - 2.4e-06 27.5 0.0 5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Inp1 PF12634.7 EFX06004.1 - 6.6e-45 152.5 1.2 7.6e-45 152.3 0.0 1.7 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 SUIM_assoc PF16619.5 EFX06004.1 - 0.078 13.0 6.1 0.29 11.2 6.1 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Inositol_P PF00459.25 EFX06006.1 - 4.3e-50 170.7 1.4 1.1e-49 169.4 1.4 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family Putative_PNPOx PF01243.20 EFX06007.1 - 0.0012 18.9 0.0 3.5 7.9 0.0 3.4 3 0 0 3 3 3 2 Pyridoxamine 5'-phosphate oxidase NAD_binding_6 PF08030.12 EFX06007.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain CorA PF01544.18 EFX06008.1 - 0.0018 17.7 0.9 0.0018 17.7 0.9 2.2 1 1 1 2 2 2 1 CorA-like Mg2+ transporter protein COX4_pro_2 PF07835.12 EFX06008.1 - 0.096 12.8 0.2 0.2 11.8 0.2 1.5 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV HD PF01966.22 EFX06010.1 - 3.8e-06 27.1 0.0 6.5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 HD domain AA_permease_2 PF13520.6 EFX06011.1 - 2.5e-81 273.7 27.9 3e-81 273.4 27.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX06011.1 - 3.6e-18 65.4 25.7 4.5e-18 65.1 25.7 1.1 1 0 0 1 1 1 1 Amino acid permease Cupin_8 PF13621.6 EFX06012.1 - 1.5e-59 201.8 0.0 1.8e-59 201.6 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EFX06012.1 - 0.00046 19.8 0.5 0.24 10.8 0.1 2.2 2 0 0 2 2 2 2 Cupin superfamily protein AvrM_N PF18247.1 EFX06012.1 - 0.14 12.1 0.0 0.75 9.8 0.0 2.0 2 0 0 2 2 2 0 Flax-rust effector AvrM N-terminal domain CAF1C_H4-bd PF12265.8 EFX06013.1 - 7.1e-15 55.0 0.0 2.5e-14 53.3 0.0 2.0 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EFX06013.1 - 1.7e-12 47.6 8.3 4.6e-06 27.3 0.1 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX06013.1 - 3.5e-08 33.6 0.1 0.0007 19.9 0.0 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CAP59_mtransfer PF11735.8 EFX06014.1 - 7.5e-65 219.0 0.0 9.7e-65 218.6 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Alpha-amylase PF00128.24 EFX06016.1 - 5.1e-113 378.1 0.0 7.4e-113 377.5 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EFX06016.1 - 0.0027 17.8 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Alpha-amylase_C PF02806.18 EFX06016.1 - 0.039 14.4 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain GHL5 PF14872.6 EFX06016.1 - 0.12 10.4 0.0 0.38 8.7 0.0 1.6 2 0 0 2 2 2 0 Hypothetical glycoside hydrolase 5 MMR_HSR1 PF01926.23 EFX06018.1 - 3.1e-14 53.0 0.1 1.2e-13 51.1 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX06018.1 - 9.9e-07 28.5 0.0 1e-05 25.2 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFX06018.1 - 0.0001 22.4 0.0 0.00075 19.6 0.0 2.2 1 1 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 EFX06018.1 - 0.00097 19.1 0.0 0.031 14.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFX06018.1 - 0.0032 17.0 0.0 0.034 13.7 0.1 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B TniB PF05621.11 EFX06018.1 - 0.0035 16.8 0.0 0.0076 15.7 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 EFX06018.1 - 0.019 14.7 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFX06018.1 - 0.021 15.4 1.2 0.034 14.6 0.1 1.9 2 0 0 2 2 2 0 ABC transporter OB_NTP_bind PF07717.16 EFX06019.1 - 7.2e-21 74.4 0.0 1.5e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFX06019.1 - 1e-17 64.4 0.8 3.3e-17 62.7 0.0 2.4 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFX06019.1 - 2e-12 47.4 0.0 4.9e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EFX06019.1 - 2.2e-10 40.7 0.6 4.9e-10 39.6 0.6 1.6 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 EFX06019.1 - 3.7e-06 26.8 0.2 7.4e-06 25.8 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EFX06019.1 - 0.00018 20.7 0.0 0.00038 19.6 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EFX06019.1 - 0.0002 21.6 0.2 0.00068 19.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFX06019.1 - 0.0026 17.5 0.1 0.0095 15.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EFX06019.1 - 0.0036 16.6 0.2 0.015 14.5 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EFX06019.1 - 0.0038 17.6 0.1 0.0081 16.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EFX06019.1 - 0.04 13.4 0.1 0.093 12.2 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 EFX06019.1 - 0.047 14.1 0.5 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 EFX06019.1 - 0.054 13.5 0.2 0.57 10.2 0.2 2.3 1 1 0 1 1 1 0 AAA domain Microtub_bd PF16796.5 EFX06019.1 - 0.074 13.0 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Microtubule binding AAA_33 PF13671.6 EFX06019.1 - 0.097 12.8 0.0 0.34 11.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EFX06019.1 - 0.17 11.5 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EFX06019.1 - 0.37 11.3 1.8 0.92 10.0 0.2 2.4 2 1 0 2 2 2 0 ABC transporter DUF1604 PF07713.13 EFX06020.1 - 1.4e-40 136.9 3.3 2e-40 136.5 0.6 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EFX06020.1 - 1.9e-06 27.6 3.3 9.1e-06 25.5 1.3 2.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EFX06020.1 - 0.0024 17.9 4.1 0.01 15.9 0.2 3.5 4 0 0 4 4 4 1 G-patch domain MbtH PF03621.13 EFX06020.1 - 0.073 12.5 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 MbtH-like protein FB_lectin PF07367.11 EFX06021.1 - 5e-27 94.5 0.0 6.1e-27 94.3 0.0 1.0 1 0 0 1 1 1 1 Fungal fruit body lectin tRNA-synt_2 PF00152.20 EFX06022.1 - 9.1e-72 241.8 0.1 1.2e-71 241.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFX06022.1 - 6e-10 39.0 0.1 1.3e-09 37.9 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFX06022.1 - 2.2e-08 33.9 0.1 0.0016 18.0 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) UCR_Fe-S_N PF10399.9 EFX06022.1 - 0.16 11.3 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal GATase PF00117.28 EFX06023.1 - 1.4e-09 38.0 0.0 1.9e-09 37.6 0.0 1.3 1 1 0 1 1 1 1 Glutamine amidotransferase class-I HAD PF12710.7 EFX06024.1 - 7.9e-21 75.3 0.1 1.3e-20 74.6 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Epimerase PF01370.21 EFX06024.1 - 8.2e-08 32.0 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFX06024.1 - 0.0053 16.2 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFX06024.1 - 0.0081 15.3 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Spt20 PF12090.8 EFX06025.1 - 0.015 14.9 3.0 0.019 14.6 3.0 1.3 1 0 0 1 1 1 0 Spt20 family Myotoxins PF00819.17 EFX06025.1 - 0.15 12.3 0.3 0.45 10.8 0.3 1.8 1 0 0 1 1 1 0 Myotoxin, crotamine TFIIA PF03153.13 EFX06025.1 - 0.2 11.7 5.9 0.26 11.2 5.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EAP30 PF04157.16 EFX06026.1 - 1.2e-40 139.3 2.5 1.6e-40 138.8 2.5 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EFX06026.1 - 3.3e-23 80.9 0.8 3.3e-23 80.9 0.8 2.2 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 EFX06026.1 - 4.8e-23 81.2 0.0 7.4e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 EFX06026.1 - 0.0027 17.6 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 GRAM domain zf-Sec23_Sec24 PF04810.15 EFX06026.1 - 0.0051 16.8 4.0 0.056 13.5 0.2 2.3 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EFX06026.1 - 0.021 14.1 0.8 0.021 14.1 0.8 2.6 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others DZR PF12773.7 EFX06026.1 - 3.1 7.9 5.3 0.85 9.7 0.3 2.2 2 1 0 2 2 2 0 Double zinc ribbon CAP PF00188.26 EFX06028.1 - 1.3e-13 51.8 3.8 2.1e-13 51.2 3.8 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rootletin PF15035.6 EFX06029.1 - 0.00076 19.5 0.9 0.00085 19.4 0.9 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion CREPT PF16566.5 EFX06029.1 - 0.028 14.6 0.2 0.069 13.3 0.0 1.5 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DNA_topoisoIV PF00521.20 EFX06030.1 - 3.4e-118 395.2 0.0 1.4e-117 393.2 0.0 1.9 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFX06030.1 - 2.9e-48 163.4 2.9 1.3e-47 161.3 2.9 2.3 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFX06030.1 - 4.7e-25 88.0 0.7 9.6e-25 87.0 0.7 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EFX06030.1 - 1.1e-11 45.3 0.0 2.6e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EFX06030.1 - 5.7e-06 26.5 0.0 2.5e-05 24.4 0.0 2.2 1 0 0 1 1 1 1 Toprim domain APAF1_C PF17908.1 EFX06030.1 - 0.12 12.4 0.6 0.34 10.9 0.6 1.8 1 0 0 1 1 1 0 APAF-1 helical domain Abhydrolase_3 PF07859.13 EFX06031.1 - 0.0002 21.3 1.2 0.0031 17.4 1.1 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX06031.1 - 0.00073 20.2 7.1 0.0018 18.9 7.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX06031.1 - 0.003 16.9 0.0 0.027 13.7 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF3089 PF11288.8 EFX06031.1 - 0.0047 16.5 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Thioesterase PF00975.20 EFX06031.1 - 0.023 14.8 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_1 PF00561.20 EFX06031.1 - 0.083 12.5 0.2 0.63 9.6 0.0 2.3 2 2 0 2 2 2 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EFX06031.1 - 0.11 12.4 0.0 14 5.5 0.0 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal COesterase PF00135.28 EFX06031.1 - 0.16 10.8 0.9 5.4 5.8 0.4 2.4 2 1 1 3 3 3 0 Carboxylesterase family Peptidase_S9 PF00326.21 EFX06031.1 - 0.18 11.3 4.4 20 4.5 4.4 2.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Inositol_P PF00459.25 EFX06032.1 - 7.4e-64 215.9 0.0 1e-63 215.5 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family Glyco_hydro_127 PF07944.12 EFX06033.1 - 4.3e-21 75.0 0.1 4.8e-20 71.6 0.0 2.2 2 0 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.13 EFX06033.1 - 0.0044 16.1 0.3 0.034 13.2 0.1 2.1 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 YvfG PF09628.10 EFX06033.1 - 0.11 12.9 0.0 2.2 8.7 0.0 2.3 2 0 0 2 2 2 0 YvfG protein Cys_Met_Meta_PP PF01053.20 EFX06035.1 - 6.7e-142 472.5 0.0 7.7e-142 472.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFX06035.1 - 3.7e-09 36.2 0.1 5.1e-09 35.8 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EFX06035.1 - 1.5e-07 31.1 0.0 2.8e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EFX06035.1 - 3.3e-07 29.6 0.1 6.4e-07 28.6 0.1 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFX06035.1 - 8e-06 25.3 0.1 1.6e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 EFX06035.1 - 0.0036 16.1 0.1 0.0056 15.4 0.1 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Met_gamma_lyase PF06838.11 EFX06035.1 - 0.012 14.2 0.0 0.016 13.8 0.0 1.3 1 0 0 1 1 1 0 Methionine gamma-lyase IMPDH PF00478.25 EFX06035.1 - 0.091 11.7 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain MGS PF02142.22 EFX06035.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 MGS-like domain GDC-P PF02347.16 EFX06035.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein ADH_zinc_N PF00107.26 EFX06035.1 - 0.12 12.3 0.1 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase GEN1_C PF18380.1 EFX06036.1 - 1.5e-29 103.0 0.1 1.5e-29 103.0 0.1 2.7 3 0 0 3 3 3 1 Holliday junction resolvase Gen1 C-terminal domain XPG_I PF00867.18 EFX06036.1 - 1.4e-24 86.2 0.0 2.9e-24 85.2 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EFX06036.1 - 3.9e-08 33.7 0.0 8.1e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain Lactonase PF10282.9 EFX06037.1 - 1.5e-12 47.4 0.0 4e-12 46.1 0.0 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Aldedh PF00171.22 EFX06038.1 - 4.6e-164 546.3 0.8 5.2e-164 546.1 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EFX06038.1 - 0.00077 19.0 0.0 0.018 14.5 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) Fungal_trans PF04082.18 EFX06040.1 - 3.4e-24 85.3 0.0 5.6e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06040.1 - 9.4e-09 35.3 13.5 1.8e-08 34.4 13.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dus PF01207.17 EFX06041.1 - 1.7e-44 152.2 1.2 3e-44 151.4 0.0 2.0 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) MTCP1 PF08991.10 EFX06043.1 - 5.5e-21 74.6 1.6 7.2e-21 74.2 1.6 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EFX06043.1 - 0.21 11.8 2.4 0.32 11.2 2.4 1.2 1 0 0 1 1 1 0 CHCH domain CN_hydrolase PF00795.22 EFX06044.1 - 7.8e-48 163.1 0.3 1.1e-47 162.6 0.3 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Spb1_C PF07780.12 EFX06045.1 - 5.5e-84 281.0 16.3 5.5e-84 281.0 16.3 3.6 4 0 0 4 4 4 1 Spb1 C-terminal domain FtsJ PF01728.19 EFX06045.1 - 1.7e-55 187.9 0.1 3.2e-55 187.0 0.1 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EFX06045.1 - 6e-48 162.8 9.5 6e-48 162.8 9.5 4.6 4 1 0 4 4 4 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 EFX06045.1 - 0.0042 16.9 0.0 0.015 15.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EFX06045.1 - 0.021 14.5 0.3 0.086 12.5 0.0 2.1 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F zf-RRN7 PF11781.8 EFX06046.1 - 2.8e-09 36.5 2.6 4.7e-09 35.8 2.6 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Corona_nucleoca PF00937.18 EFX06046.1 - 0.002 17.3 6.7 0.0042 16.2 6.7 1.5 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein RSRP PF17069.5 EFX06046.1 - 0.16 11.5 12.0 0.28 10.7 12.0 1.4 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 TP2 PF01254.18 EFX06046.1 - 0.29 11.8 7.0 0.65 10.6 7.0 1.5 1 0 0 1 1 1 0 Nuclear transition protein 2 Transformer PF06495.11 EFX06046.1 - 0.39 10.8 9.3 0.048 13.8 4.6 1.8 2 0 0 2 2 2 0 Fruit fly transformer protein PRP38_assoc PF12871.7 EFX06046.1 - 8.7 7.0 20.2 0.37 11.4 13.5 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term GSDH PF07995.11 EFX06047.1 - 0.018 14.4 0.2 0.41 9.9 0.2 2.7 2 1 0 2 2 2 0 Glucose / Sorbosone dehydrogenase Peptidase_S10 PF00450.22 EFX06048.1 - 2.6e-57 195.1 0.0 4.4e-57 194.4 0.0 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase RNA_pol_I_A49 PF06870.12 EFX06049.1 - 2.8e-94 316.2 0.2 3.4e-94 315.9 0.2 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Ceramidase_alk PF04734.13 EFX06050.1 - 1.7e-199 663.7 0.5 8.7e-199 661.4 0.5 1.8 1 1 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EFX06050.1 - 5.7e-61 205.2 0.1 9.1e-61 204.6 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal KilA-N PF04383.13 EFX06051.1 - 0.0024 17.7 0.0 0.0054 16.6 0.0 1.6 1 0 0 1 1 1 1 KilA-N domain DUF4179 PF13786.6 EFX06051.1 - 0.18 12.3 1.7 0.5 10.9 1.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) FSA_C PF10479.9 EFX06051.1 - 6.2 4.8 11.0 9.6 4.2 11.0 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus IML1 PF12257.8 EFX06053.1 - 1.7e-114 381.8 0.1 2.3e-114 381.4 0.1 1.2 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EFX06053.1 - 7e-25 86.9 0.0 1.9e-24 85.5 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) HSP70 PF00012.20 EFX06054.1 - 4.3e-223 741.8 4.1 4.9e-223 741.7 4.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFX06054.1 - 2.3e-15 56.3 0.3 5.3e-14 51.8 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EFX06054.1 - 0.00031 20.5 0.0 0.00066 19.5 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EFX06054.1 - 0.069 12.1 0.9 0.24 10.3 0.4 2.1 2 1 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.6 EFX06054.1 - 0.082 13.3 0.6 25 5.4 0.0 3.2 3 0 0 3 3 3 0 Cell division protein FtsA Ank_2 PF12796.7 EFX06055.1 - 1.2e-41 141.2 11.8 4.4e-08 33.6 0.0 13.4 8 5 6 15 15 15 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX06055.1 - 2.8e-27 94.7 20.7 0.0058 17.2 0.0 16.6 17 3 4 21 21 21 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06055.1 - 9.6e-17 59.4 15.3 2.6 8.9 0.0 18.1 21 0 0 21 21 21 3 Ankyrin repeat Ank_5 PF13857.6 EFX06055.1 - 9.3e-13 48.1 4.7 0.00033 20.9 0.0 8.9 10 0 0 10 10 10 3 Ankyrin repeats (many copies) Ank PF00023.30 EFX06055.1 - 1.8e-10 40.8 34.0 0.0017 18.7 0.0 15.6 19 0 0 19 19 19 2 Ankyrin repeat U-box PF04564.15 EFX06056.1 - 1.3e-21 76.5 0.0 2.9e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 U-box domain TPR_2 PF07719.17 EFX06056.1 - 4.4e-09 35.8 1.5 0.0018 18.2 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFX06056.1 - 2.3e-07 30.4 0.8 1.5e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 TPR repeat TPR_17 PF13431.6 EFX06056.1 - 8.5e-07 28.9 1.1 0.041 14.3 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX06056.1 - 3.3e-06 26.7 4.1 0.53 10.2 1.7 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFX06056.1 - 0.00021 21.7 4.2 0.27 11.8 0.5 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX06056.1 - 0.00086 19.9 0.1 2.4 9.2 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 EFX06056.1 - 0.0013 19.5 12.0 0.0027 18.4 12.0 1.5 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_12 PF13424.6 EFX06056.1 - 0.0044 17.3 3.2 0.072 13.4 0.4 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-Nse PF11789.8 EFX06056.1 - 0.0063 16.3 0.0 0.14 12.0 0.0 2.5 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TPR_16 PF13432.6 EFX06056.1 - 0.012 16.3 1.2 3.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-NOSIP PF15906.5 EFX06056.1 - 0.057 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein eIF-1a PF01176.19 EFX06057.1 - 4.7e-14 51.9 0.0 1e-13 50.8 0.0 1.6 2 0 0 2 2 2 1 Translation initiation factor 1A / IF-1 zf-U1 PF06220.12 EFX06058.1 - 5.2e-08 32.5 0.2 8.5e-08 31.8 0.2 1.4 1 0 0 1 1 1 1 U1 zinc finger UQ_con PF00179.26 EFX06059.1 - 7.7e-12 45.0 0.0 1.9e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Complex1_LYR PF05347.15 EFX06059.1 - 3e-05 24.0 0.0 9.6e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Complex 1 protein (LYR family) RWD PF05773.22 EFX06059.1 - 0.022 15.1 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 RWD domain Fructosamin_kin PF03881.14 EFX06060.1 - 1.1e-17 64.2 0.0 1.3e-17 64.0 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase Ig_6 PF18452.1 EFX06060.1 - 0.21 11.2 0.0 0.37 10.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Toxin_7 PF05980.12 EFX06061.1 - 0.54 10.5 9.0 1.4 9.2 9.0 1.7 1 0 0 1 1 1 0 Toxin 7 SPX PF03105.19 EFX06061.1 - 2.6 7.9 9.0 2.9 7.7 9.0 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 EFX06061.1 - 6.8 5.4 10.0 7.9 5.2 10.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MCD_N PF17408.2 EFX06064.1 - 0.98 9.6 3.3 14 5.9 0.1 3.1 2 1 1 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain Mcl1_mid PF12341.8 EFX06066.1 - 3.6e-96 322.0 0.0 1.7e-94 316.5 0.0 2.2 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 EFX06066.1 - 3.4e-19 68.9 0.0 3.3e-08 33.7 0.1 5.9 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFX06066.1 - 1.1e-18 67.3 3.7 6.6e-07 29.9 0.0 7.6 7 1 1 8 8 8 4 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFX06066.1 - 0.00021 20.5 0.0 0.001 18.2 0.0 1.9 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 EFX06066.1 - 0.00023 21.1 0.0 0.0066 16.3 0.0 2.6 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EFX06066.1 - 0.012 13.7 0.2 0.032 12.3 0.1 1.6 1 1 1 2 2 2 0 IKI3 family Ge1_WD40 PF16529.5 EFX06066.1 - 0.024 13.6 0.0 5.2 5.9 0.1 2.8 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFX06066.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.4 1 1 0 1 1 1 0 WD40-like domain DNA_pol_alpha_N PF12254.8 EFX06066.1 - 0.45 10.6 4.6 1.3 9.2 4.6 1.8 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal MRP-L47 PF06984.13 EFX06067.1 - 1.2e-23 83.0 0.0 1.9e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NACHT PF05729.12 EFX06068.1 - 2.4e-10 40.6 0.0 5.5e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFX06068.1 - 0.00069 19.9 0.0 0.0082 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFX06068.1 - 0.0043 16.3 0.0 0.0063 15.7 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFX06068.1 - 0.0081 16.6 0.5 0.054 13.9 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFX06068.1 - 0.01 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_7 PF12775.7 EFX06068.1 - 0.028 13.9 0.0 0.047 13.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Hpr_kinase_C PF07475.12 EFX06068.1 - 0.035 13.6 0.0 3.9 7.0 0.0 2.6 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain ATPase PF06745.13 EFX06068.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC RNA_helicase PF00910.22 EFX06068.1 - 0.067 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase MeaB PF03308.16 EFX06068.1 - 0.081 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EFX06068.1 - 0.081 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFX06068.1 - 0.091 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EFX06068.1 - 0.098 13.2 0.0 0.29 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EFX06068.1 - 0.11 11.6 0.0 0.33 10.1 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF815) NTPase_1 PF03266.15 EFX06068.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 NTPase TPR_MalT PF17874.1 EFX06068.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region Abi_C PF14355.6 EFX06068.1 - 0.19 11.8 0.2 2.4 8.3 0.0 2.5 3 0 0 3 3 3 0 Abortive infection C-terminus Cohesin_load PF10345.9 EFX06069.1 - 2.3e-117 393.0 0.1 2.3e-117 393.0 0.1 2.8 2 1 0 2 2 2 1 Cohesin loading factor RabGAP-TBC PF00566.18 EFX06070.1 - 2.2e-47 161.5 0.0 4.3e-47 160.5 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HGD-D PF06050.13 EFX06070.1 - 0.088 12.6 0.4 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component Rnk_N PF14760.6 EFX06070.1 - 0.11 13.0 3.5 16 6.1 0.1 3.6 2 0 0 2 2 2 0 Rnk N-terminus CENP-K PF11802.8 EFX06070.1 - 1.2 8.7 5.7 2.1 7.9 0.1 2.3 2 0 0 2 2 2 0 Centromere-associated protein K IFT57 PF10498.9 EFX06070.1 - 3.4 6.5 10.4 0.57 9.1 0.2 2.5 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 EFX06070.1 - 7.3 5.4 14.9 2 7.2 4.8 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein WD40 PF00400.32 EFX06071.1 - 1.7e-13 50.8 11.2 0.011 16.6 0.1 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX06071.1 - 1.1e-07 32.1 0.1 0.098 13.0 0.0 5.6 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_23 PF13489.6 EFX06072.1 - 1.7e-18 67.0 0.0 2.9e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX06072.1 - 1.3e-12 48.3 0.0 3.4e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06072.1 - 1.2e-11 45.1 0.0 2.8e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ABC_tran PF00005.27 EFX06072.1 - 2e-11 44.5 0.0 3.9e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter Methyltransf_31 PF13847.6 EFX06072.1 - 6.6e-08 32.5 0.0 1.9e-06 27.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX06072.1 - 6.5e-06 25.6 0.0 3.8e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFX06072.1 - 3e-05 24.7 0.0 0.00017 22.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain AAA_24 PF13479.6 EFX06072.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain MTS PF05175.14 EFX06072.1 - 0.0029 17.2 0.0 0.019 14.5 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX06072.1 - 0.018 14.5 0.0 0.048 13.1 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase PRK PF00485.18 EFX06072.1 - 0.019 14.7 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 EFX06072.1 - 0.025 14.3 0.1 0.063 13.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EFX06072.1 - 0.046 14.0 0.0 0.079 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain GidB PF02527.15 EFX06072.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DUF87 PF01935.17 EFX06072.1 - 0.083 13.0 0.2 0.26 11.3 0.1 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_21 PF13304.6 EFX06072.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Methyltransf_PK PF05891.12 EFX06072.1 - 0.13 11.8 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 EFX06072.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Med4 PF10018.9 EFX06073.1 - 7.4e-33 113.9 0.0 1.4e-32 113.0 0.0 1.5 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 DAP10 PF07213.11 EFX06076.1 - 0.021 14.8 0.2 0.021 14.8 0.2 2.1 2 0 0 2 2 2 0 DAP10 membrane protein TMEM154 PF15102.6 EFX06076.1 - 0.067 13.1 0.2 0.13 12.1 0.1 1.5 1 1 0 1 1 1 0 TMEM154 protein family USP8_dimer PF08969.11 EFX06077.1 - 0.032 14.4 0.6 0.074 13.2 0.2 1.8 2 0 0 2 2 2 0 USP8 dimerisation domain Mannosyl_trans2 PF04188.13 EFX06078.1 - 4.5e-54 184.4 0.6 6.6e-54 183.9 0.6 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) YTH PF04146.15 EFX06078.1 - 3.2e-36 124.8 0.8 1.7e-35 122.4 0.8 2.0 1 1 0 1 1 1 1 YT521-B-like domain BRI3BP PF14965.6 EFX06078.1 - 0.24 10.9 2.0 0.69 9.4 2.0 1.7 1 0 0 1 1 1 0 Negative regulator of p53/TP53 TGF_beta_GS PF08515.12 EFX06078.1 - 0.3 10.6 1.3 0.64 9.6 1.3 1.6 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Mo25 PF08569.11 EFX06079.1 - 1.5e-127 425.5 0.0 1.8e-127 425.3 0.0 1.0 1 0 0 1 1 1 1 Mo25-like Herpes_UL6 PF01763.16 EFX06080.1 - 6.6e-05 21.6 0.0 9.1e-05 21.2 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus UL6 like DUF2520 PF10728.9 EFX06080.1 - 0.048 13.4 1.2 0.18 11.6 1.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF2520) SLATT_6 PF18169.1 EFX06080.1 - 0.1 12.2 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 Tht1 PF04163.12 EFX06081.1 - 0.08 11.7 1.8 0.12 11.1 1.8 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein BCLP PF12304.8 EFX06082.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Beta-casein like protein HRG PF16954.5 EFX06082.1 - 0.49 10.8 3.4 2.5 8.6 0.9 2.6 2 1 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Sin_N PF04801.13 EFX06083.1 - 7.6e-20 71.5 0.0 7.8e-10 38.5 0.0 2.8 2 1 1 3 3 3 2 Sin-like protein conserved region SR-25 PF10500.9 EFX06083.1 - 5.9 6.4 10.9 6.7 6.3 2.1 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Aha1_N PF09229.11 EFX06084.1 - 8.2e-39 132.9 0.4 8.2e-39 132.9 0.4 1.6 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EFX06084.1 - 9.4e-19 67.9 0.5 1.7e-18 67.0 0.5 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DNA_photolyase PF00875.18 EFX06084.1 - 0.079 13.0 0.4 0.53 10.3 0.3 2.1 2 0 0 2 2 2 0 DNA photolyase DUF3752 PF12572.8 EFX06085.1 - 3.2e-36 125.2 39.5 2.2e-21 76.9 7.8 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF3752) Pro_isomerase PF00160.21 EFX06086.1 - 2.1e-46 158.1 0.3 2.7e-46 157.7 0.3 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TFIIA PF03153.13 EFX06087.1 - 3.7e-96 323.7 9.6 4.2e-96 323.5 9.6 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 EFX06087.1 - 0.18 10.9 8.3 0.31 10.1 8.3 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Cwf_Cwc_15 PF04889.12 EFX06087.1 - 0.59 9.8 16.3 1.2 8.8 16.4 1.6 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3295 PF11702.8 EFX06087.1 - 0.95 8.8 6.8 0.057 12.8 1.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) DNA_pol_phi PF04931.13 EFX06087.1 - 4.4 5.3 10.3 6.1 4.8 10.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Aldolase_II PF00596.21 EFX06088.1 - 1.1e-39 136.3 0.0 1.7e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain NRDD PF13597.6 EFX06089.1 - 9.1e-174 579.3 0.0 1.1e-173 579.1 0.0 1.0 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Radical_SAM PF04055.21 EFX06089.1 - 1.3e-11 45.2 0.0 3.7e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EFX06089.1 - 8.2e-08 32.4 0.0 6e-07 29.6 0.0 2.4 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 EFX06089.1 - 1.4e-06 28.6 0.0 5.2e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain Meleagrin PF08189.11 EFX06090.1 - 0.13 11.9 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Meleagrin/Cygnin family Bromodomain PF00439.25 EFX06091.1 - 5.7e-38 128.9 0.2 6.7e-18 64.5 0.0 2.3 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EFX06091.1 - 9.9e-14 51.2 0.0 1.7e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 BAH domain DUF913 PF06025.12 EFX06091.1 - 0.011 14.7 0.6 0.48 9.3 0.0 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) CK2S PF15011.6 EFX06091.1 - 0.059 13.3 0.6 0.24 11.3 0.1 2.1 2 0 0 2 2 2 0 Casein Kinase 2 substrate Pilosulin PF17499.2 EFX06091.1 - 4.3 7.6 5.3 9.4 6.5 5.3 1.5 1 0 0 1 1 1 0 Ant venom peptides Aldo_ket_red PF00248.21 EFX06092.1 - 1.1e-67 228.4 0.0 1.2e-67 228.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FAS_I_H PF18314.1 EFX06093.1 - 8.9e-77 257.3 0.1 2.7e-76 255.7 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EFX06093.1 - 1.2e-75 253.3 0.1 3.4e-75 251.8 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EFX06093.1 - 6.4e-20 71.8 0.1 1.4e-19 70.7 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EFX06093.1 - 2.4e-18 66.3 0.0 5.9e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EFX06093.1 - 6e-12 45.6 0.1 1.9e-11 44.0 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EFX06093.1 - 0.024 14.6 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 KR domain Acetyltransf_3 PF13302.7 EFX06094.1 - 4.8e-24 85.6 0.0 5.7e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFX06094.1 - 5.9e-05 23.3 0.0 0.0009 19.5 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family eIF-5a PF01287.20 EFX06095.1 - 3.6e-28 97.5 1.7 4.9e-28 97.0 1.7 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EFX06095.1 - 0.0024 17.8 0.8 0.012 15.6 0.0 2.3 3 0 0 3 3 3 1 Elongation factor P (EF-P) KOW-like domain Tmemb_14 PF03647.13 EFX06096.1 - 2e-23 83.0 6.5 2.3e-23 82.7 6.5 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 EFX06096.1 - 0.059 13.7 1.0 0.39 11.0 1.0 2.2 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 19 CytB6-F_Fe-S PF08802.10 EFX06096.1 - 4.2 7.5 6.4 22 5.2 0.7 2.7 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit RR_TM4-6 PF06459.12 EFX06097.1 - 1.3 8.8 9.8 2.1 8.1 9.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MFS_1 PF07690.16 EFX06098.1 - 2.3e-25 89.3 44.9 5.1e-16 58.5 18.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EFX06098.1 - 3.4 5.8 10.8 0.092 11.0 0.4 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Aminotran_5 PF00266.19 EFX06100.1 - 6.4e-06 25.4 0.0 1.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DUF1018 PF06252.12 EFX06101.1 - 0.72 10.9 5.2 0.34 11.9 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1018) NACHT PF05729.12 EFX06102.1 - 0.0036 17.2 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFX06102.1 - 0.14 12.6 0.1 0.28 11.6 0.1 1.5 1 1 1 2 2 2 0 AAA ATPase domain DUF2011 PF09428.10 EFX06103.1 - 6.1e-14 52.0 0.0 7e-13 48.6 0.0 2.3 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2011) Methyltransf_16 PF10294.9 EFX06104.1 - 3.9e-17 62.5 0.0 4.2e-16 59.2 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EFX06104.1 - 0.019 15.7 0.2 0.049 14.3 0.2 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFX06104.1 - 0.038 13.8 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EFX06104.1 - 0.067 12.6 0.3 0.11 11.9 0.3 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFX06104.1 - 0.15 11.6 0.0 0.4 10.2 0.1 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Asp PF00026.23 EFX06105.1 - 8.7e-63 212.6 8.4 8.7e-63 212.6 8.4 1.4 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX06105.1 - 1.3e-08 35.3 3.6 1.3e-08 35.3 3.6 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EFX06105.1 - 0.034 14.8 0.3 9.7 6.9 0.1 3.0 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 EFX06105.1 - 0.11 13.1 0.0 14 6.3 0.0 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Cation_efflux PF01545.21 EFX06106.1 - 4.2e-48 163.7 0.9 5.4e-48 163.4 0.9 1.1 1 0 0 1 1 1 1 Cation efflux family NicO PF03824.16 EFX06106.1 - 0.0054 16.1 6.8 0.0089 15.4 6.8 1.4 1 0 0 1 1 1 1 High-affinity nickel-transport protein Nicastrin PF05450.15 EFX06106.1 - 0.15 11.5 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 Nicastrin Zip PF02535.22 EFX06106.1 - 7.1 5.7 30.9 11 5.2 0.4 3.0 1 1 2 3 3 3 0 ZIP Zinc transporter TP_methylase PF00590.20 EFX06107.1 - 7.8e-23 81.5 0.0 1.3e-22 80.8 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Fungal_trans PF04082.18 EFX06108.1 - 8.2e-27 93.9 0.1 3.6e-22 78.7 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06108.1 - 3.9e-09 36.5 8.4 6.6e-09 35.7 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GATase_7 PF13537.6 EFX06109.1 - 1.1e-08 35.1 0.0 1.9e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFX06109.1 - 6.6e-08 32.8 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EFX06109.1 - 5.1e-07 29.3 0.3 1.8e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain DUF116 PF01976.17 EFX06109.1 - 0.1 12.1 0.3 0.6 9.6 0.3 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF116 SPRY PF00622.28 EFX06111.1 - 0.00036 20.6 0.2 0.0015 18.6 0.0 2.1 2 1 1 3 3 3 1 SPRY domain ANAPC4_WD40 PF12894.7 EFX06112.1 - 5.8e-18 65.0 5.9 1.6e-05 25.1 0.1 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFX06112.1 - 4.4e-15 55.8 21.9 0.00013 22.7 0.2 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.11 EFX06112.1 - 4.4e-07 30.0 0.1 3.7e-05 23.7 0.1 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFX06112.1 - 5.9e-06 25.5 0.1 0.00035 19.6 0.0 3.2 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Pterin_bind PF00809.22 EFX06113.1 - 6.4e-79 265.1 1.6 8.9e-79 264.6 1.6 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EFX06113.1 - 1.5e-36 125.3 0.0 5.2e-36 123.6 0.0 1.9 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) tRNA-synt_2b PF00587.25 EFX06114.1 - 7.1e-34 117.3 0.0 1.1e-33 116.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFX06114.1 - 3.2e-06 27.2 0.0 8.4e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain ABC2_membrane PF01061.24 EFX06115.1 - 4.9e-77 258.1 55.0 1.5e-42 145.4 22.7 3.0 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EFX06115.1 - 3.8e-33 114.9 0.0 6.6e-16 59.1 0.0 2.5 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EFX06115.1 - 5.2e-33 112.8 10.4 1.1e-28 98.9 0.1 4.1 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EFX06115.1 - 2.9e-15 56.7 0.0 8e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EFX06115.1 - 3e-08 34.2 0.3 0.0086 16.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EFX06115.1 - 3.5e-05 23.5 0.0 0.00083 19.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFX06115.1 - 0.00015 22.3 0.0 0.0014 19.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFX06115.1 - 0.00026 20.9 0.1 0.0017 18.3 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase ABC2_membrane_3 PF12698.7 EFX06115.1 - 0.00068 18.8 10.6 0.00068 18.8 10.6 2.8 3 0 0 3 3 3 1 ABC-2 family transporter protein AAA_33 PF13671.6 EFX06115.1 - 0.00071 19.7 0.1 0.044 13.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFX06115.1 - 0.00073 20.0 0.0 1 9.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFX06115.1 - 0.0013 18.5 1.0 0.059 13.1 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFX06115.1 - 0.0031 17.8 0.2 1.2 9.4 0.1 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFX06115.1 - 0.0048 16.5 1.4 0.33 10.5 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFX06115.1 - 0.012 15.5 0.6 1.8 8.4 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_21 PF13304.6 EFX06115.1 - 0.015 15.1 0.0 2.3 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EFX06115.1 - 0.019 14.7 1.8 1 9.0 0.2 2.6 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EFX06115.1 - 0.043 14.2 0.2 0.72 10.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EFX06115.1 - 0.05 13.0 0.0 0.95 8.9 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EFX06115.1 - 0.14 12.4 0.2 2.1 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFX06115.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFX06115.1 - 0.15 11.8 0.1 7.7 6.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EFX06115.1 - 0.17 11.6 0.3 4.4 6.9 0.1 2.9 2 1 1 3 3 3 0 Thymidylate kinase AMP-binding PF00501.28 EFX06116.1 - 1.7e-71 241.1 0.0 2.3e-71 240.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFX06116.1 - 2.8e-61 206.9 0.0 4.2e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFX06116.1 - 1.1e-08 34.8 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EFX06116.1 - 9.9e-08 32.2 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_10 PF13460.6 EFX06116.1 - 2.8e-06 27.3 0.2 2.2e-05 24.4 0.0 2.4 2 1 0 2 2 2 1 NAD(P)H-binding AMP-binding_C PF13193.6 EFX06116.1 - 0.00035 21.5 0.0 0.0027 18.6 0.0 2.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 EFX06116.1 - 0.00073 18.6 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFX06116.1 - 0.0066 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 EFX06117.1 - 7.7e-11 41.5 24.1 7.7e-11 41.5 24.1 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX06117.1 - 2.1e-06 26.9 0.2 6.5e-06 25.3 0.0 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter Proteasome PF00227.26 EFX06118.1 - 1.2e-45 155.3 0.0 1.5e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EFX06118.1 - 5.8e-14 51.2 0.1 5.8e-14 51.2 0.1 1.9 2 0 0 2 2 2 1 Proteasome beta subunits C terminal NDT80_PhoG PF05224.12 EFX06119.1 - 1.1e-30 107.3 0.0 1.1e-30 107.3 0.0 2.6 4 0 0 4 4 4 1 NDT80 / PhoG like DNA-binding family DnaJ PF00226.31 EFX06120.1 - 3.8e-14 52.5 0.8 1.1e-13 51.0 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain TGT PF01702.18 EFX06121.1 - 3e-134 447.6 0.0 3.6e-134 447.4 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.16 EFX06122.1 - 3.8e-40 137.9 26.3 3.8e-40 137.9 26.3 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFX06122.1 - 0.0071 16.1 2.7 0.02 14.6 2.7 1.8 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Folate_carrier PF01770.18 EFX06122.1 - 0.15 10.8 6.9 0.019 13.7 1.1 2.2 2 1 1 3 3 3 0 Reduced folate carrier DUF1772 PF08592.11 EFX06122.1 - 0.55 10.5 13.2 19 5.5 3.7 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) ESSS PF10183.9 EFX06122.1 - 0.94 9.7 3.3 1.3 9.2 0.2 2.7 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) TauD PF02668.16 EFX06123.1 - 3.4e-53 181.2 0.1 4.6e-53 180.7 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans_2 PF11951.8 EFX06124.1 - 2.5e-23 82.5 3.1 3.2e-23 82.2 3.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Carn_acyltransf PF00755.20 EFX06125.1 - 1.5e-210 700.8 0.0 5.6e-182 606.5 0.0 2.0 2 0 0 2 2 2 2 Choline/Carnitine o-acyltransferase MFS_1 PF07690.16 EFX06126.1 - 6e-25 87.9 21.2 7.5e-25 87.6 21.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Methyltransf_23 PF13489.6 EFX06127.1 - 9.7e-12 45.0 0.0 1.4e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06127.1 - 1.5e-06 28.8 0.0 2.9e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX06127.1 - 0.00012 22.7 0.0 0.00052 20.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX06127.1 - 0.00079 20.1 0.0 0.0063 17.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX06127.1 - 0.027 14.3 0.0 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Amidoligase_2 PF12224.8 EFX06128.1 - 8.3e-11 42.0 0.0 8.1e-10 38.8 0.0 1.9 1 1 0 1 1 1 1 Putative amidoligase enzyme FAA_hydrolase PF01557.18 EFX06129.1 - 8.1e-44 149.9 0.1 1.2e-43 149.3 0.1 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family S1 PF00575.23 EFX06129.1 - 0.16 12.3 1.4 0.72 10.2 0.3 2.5 2 1 0 2 2 2 0 S1 RNA binding domain Fungal_trans PF04082.18 EFX06130.1 - 1.4e-18 66.9 0.1 2.5e-18 66.1 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06130.1 - 2.3e-06 27.6 10.4 4.3e-06 26.7 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.14 EFX06130.1 - 0.07 12.5 1.8 0.16 11.4 1.8 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MTP18 PF10558.9 EFX06131.1 - 1.2e-81 272.7 0.6 1.5e-81 272.4 0.6 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF3333 PF11812.8 EFX06131.1 - 0.12 12.5 0.1 7.4 6.8 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3333) DUF3716 PF12511.8 EFX06132.1 - 8.6e-14 51.3 6.0 1.4e-13 50.6 6.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) CENP-C_C PF11699.8 EFX06132.1 - 0.0045 17.2 0.0 0.009 16.2 0.0 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like zf-C2H2_aberr PF17017.5 EFX06132.1 - 0.042 14.0 0.0 4.2 7.5 0.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger Cwf_Cwc_15 PF04889.12 EFX06132.1 - 1.3 8.7 9.6 2.1 8.0 9.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Glyoxalase PF00903.25 EFX06133.1 - 1.1e-06 28.9 3.0 1.1e-06 28.9 3.0 2.3 2 2 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Sod_Cu PF00080.20 EFX06134.1 - 7.9e-09 35.8 0.0 1.3e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) RIFIN PF02009.16 EFX06135.1 - 0.031 14.2 2.3 0.029 14.3 2.3 1.1 1 0 0 1 1 1 0 Rifin Mucin PF01456.17 EFX06135.1 - 5.5 7.0 35.9 12 5.9 35.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Med3 PF11593.8 EFX06135.1 - 9 5.4 25.9 12 5.0 25.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Na_H_Exchanger PF00999.21 EFX06136.1 - 1.6e-61 208.2 38.7 2.6e-61 207.5 38.7 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family zf-C2H2 PF00096.26 EFX06137.1 - 0.056 13.9 12.1 0.48 11.0 2.6 3.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX06137.1 - 0.23 12.4 7.3 13 7.0 0.4 3.6 2 1 0 2 2 2 0 C2H2-type zinc finger Peptidase_C48 PF02902.19 EFX06138.1 - 7.2e-05 22.7 0.1 0.00012 22.0 0.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 EFX06138.1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Vaccinia virus I7 processing peptidase Hydrolase_6 PF13344.6 EFX06139.1 - 2.1e-22 79.2 0.0 3.9e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFX06139.1 - 4.9e-13 48.9 0.0 2.3e-12 46.8 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like SET PF00856.28 EFX06140.1 - 0.031 14.7 0.0 4.1 7.8 0.0 2.8 1 1 0 1 1 1 0 SET domain Pkinase PF00069.25 EFX06141.1 - 4.4e-49 167.2 0.0 7.2e-33 114.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFX06141.1 - 5.3e-21 75.1 0.0 1.9e-19 70.0 0.0 3.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFX06141.1 - 7e-06 25.6 0.0 1.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFX06141.1 - 0.0018 18.2 0.0 0.079 12.9 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family MFS_1 PF07690.16 EFX06143.1 - 8.6e-29 100.6 45.8 1.5e-28 99.8 45.1 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EFX06143.1 - 0.00039 19.8 22.2 0.0064 15.8 10.3 2.4 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Orf78 PF06024.12 EFX06143.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Dcc1 PF09724.9 EFX06145.1 - 2.5e-07 30.3 0.0 3.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Ribosomal_S2 PF00318.20 EFX06146.1 - 2.8e-26 92.1 0.2 1.7e-14 53.6 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EFX06146.1 - 2.4e-05 25.6 14.2 4.2e-05 24.8 14.2 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Peptidase_S28 PF05577.12 EFX06147.1 - 4.2e-49 167.5 0.0 1.5e-48 165.7 0.0 1.7 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EFX06147.1 - 0.044 13.2 0.1 0.1 12.1 0.1 1.5 1 1 1 2 2 2 0 Prolyl oligopeptidase family QCR10 PF09796.9 EFX06148.1 - 2e-26 91.8 0.5 2.5e-26 91.5 0.5 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) CbiD PF01888.17 EFX06148.1 - 0.19 11.0 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 CbiD 2-Hacid_dh_C PF02826.19 EFX06149.1 - 8.1e-39 132.8 0.0 2.2e-38 131.4 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX06149.1 - 4.6e-23 81.3 0.0 6.8e-23 80.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 EFX06149.1 - 0.00019 21.0 0.0 0.00053 19.6 0.0 1.7 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 EFX06149.1 - 0.00044 20.8 0.2 0.0028 18.2 0.0 2.3 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EFX06149.1 - 0.0077 16.5 2.1 2.5 8.3 0.1 3.1 3 1 0 3 3 3 2 Saccharopine dehydrogenase NADP binding domain XdhC_C PF13478.6 EFX06149.1 - 0.017 15.7 0.0 0.059 13.9 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 EFX06149.1 - 0.028 14.5 0.4 0.11 12.6 0.4 1.9 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ThiF PF00899.21 EFX06149.1 - 0.22 10.8 0.9 0.61 9.4 0.9 1.7 1 0 0 1 1 1 0 ThiF family DUF2749 PF10907.8 EFX06149.1 - 0.24 11.6 1.7 0.83 9.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Pro_isomerase PF00160.21 EFX06150.1 - 5.9e-50 169.6 0.1 1.8e-49 168.1 0.1 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EFX06150.1 - 2.8e-09 37.4 0.0 8e-05 23.3 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX06150.1 - 0.0022 18.3 0.0 0.27 11.6 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFX06150.1 - 0.0077 14.9 0.0 0.62 8.6 0.0 2.9 3 0 0 3 3 3 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFX06150.1 - 0.14 11.1 0.2 2.5 7.0 0.0 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Fungal_trans PF04082.18 EFX06151.1 - 3.5e-17 62.3 0.0 5.4e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain BCS1_N PF08740.11 EFX06151.1 - 0.016 15.2 0.9 0.029 14.3 0.9 1.3 1 0 0 1 1 1 0 BCS1 N terminal Zn_clus PF00172.18 EFX06151.1 - 0.22 11.6 4.6 0.39 10.9 4.6 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FMO-like PF00743.19 EFX06152.1 - 2.1e-07 29.8 1.1 0.036 12.5 0.2 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFX06152.1 - 5.8e-07 29.7 0.3 2.8e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFX06152.1 - 0.0039 16.4 1.0 6.2 5.9 0.1 3.9 3 2 1 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EFX06152.1 - 0.0044 17.0 0.2 0.79 9.7 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFX06152.1 - 0.015 14.6 0.0 2 7.6 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFX06152.1 - 0.17 11.1 0.0 7 5.8 0.0 2.2 2 0 0 2 2 2 0 Thi4 family Abhydrolase_1 PF00561.20 EFX06153.1 - 1.6e-48 165.6 0.0 2.4e-48 165.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX06153.1 - 0.083 13.5 8.6 0.61 10.7 8.6 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX06153.1 - 0.19 11.0 0.0 14 4.9 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DnaJ PF00226.31 EFX06154.1 - 4.2e-12 46.0 0.1 4.2e-12 46.0 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain Nop53 PF07767.11 EFX06154.1 - 0.22 10.9 25.8 0.4 10.0 25.8 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Borrelia_P83 PF05262.11 EFX06154.1 - 6.7 5.1 18.1 8.7 4.7 18.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Myb_DNA-bind_2 PF08914.11 EFX06155.1 - 9.7e-15 54.5 4.5 4.8e-14 52.3 0.4 2.4 2 0 0 2 2 2 1 Rap1 Myb domain Rap1-DNA-bind PF09197.10 EFX06155.1 - 8.1e-09 36.0 1.5 2.3e-06 28.2 0.2 2.9 2 0 0 2 2 2 2 Rap1, DNA-binding BRCT_2 PF16589.5 EFX06155.1 - 3.8e-05 24.0 0.0 9.5e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain ARID PF01388.21 EFX06155.1 - 0.00027 21.5 0.0 0.00065 20.3 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF768 PF05589.11 EFX06155.1 - 0.044 13.8 0.0 14 5.8 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF768) EamA PF00892.20 EFX06156.1 - 0.046 13.9 14.2 0.56 10.4 14.2 2.0 1 1 0 1 1 1 0 EamA-like transporter family TMEM234 PF10639.9 EFX06156.1 - 0.068 13.2 1.0 0.1 12.7 1.0 1.2 1 0 0 1 1 1 0 Putative transmembrane family 234 SNF2_N PF00176.23 EFX06157.1 - 1.5e-21 76.5 0.0 2.3e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX06157.1 - 1.1e-05 25.7 0.0 3e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain rhaM PF05336.13 EFX06157.1 - 0.058 13.5 0.1 0.15 12.1 0.1 1.8 1 1 0 1 1 1 0 L-rhamnose mutarotase zf-RING_5 PF14634.6 EFX06157.1 - 3.3 7.8 10.3 0.35 10.8 5.2 2.1 2 0 0 2 2 2 0 zinc-RING finger domain OTU PF02338.19 EFX06158.1 - 0.00041 20.8 0.0 0.00067 20.2 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease CLP1_N PF16573.5 EFX06160.1 - 6.6e-25 87.2 0.0 9.7e-25 86.6 0.0 1.3 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EFX06160.1 - 4.5e-23 81.9 0.0 1.2e-22 80.5 0.0 1.8 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 EFX06160.1 - 1.2e-22 80.7 0.0 1.7e-21 76.9 0.0 2.6 2 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EFX06160.1 - 0.13 12.7 0.1 0.25 11.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain Mito_carr PF00153.27 EFX06162.1 - 1.8e-47 159.2 10.8 2.1e-15 56.4 0.2 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein SR-25 PF10500.9 EFX06162.1 - 0.0022 17.7 0.7 0.0035 17.0 0.7 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RIFIN PF02009.16 EFX06162.1 - 0.034 14.0 0.7 0.056 13.3 0.7 1.3 1 0 0 1 1 1 0 Rifin SOBP PF15279.6 EFX06162.1 - 0.45 11.1 2.3 0.68 10.5 2.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Herpes_pp85 PF04637.12 EFX06162.1 - 8.3 4.7 5.9 13 4.1 5.9 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Acyl_transf_3 PF01757.22 EFX06163.1 - 1.7e-27 96.4 17.4 6.2e-27 94.5 17.4 1.8 1 1 0 1 1 1 1 Acyltransferase family Sof1 PF04158.14 EFX06164.1 - 1e-31 109.0 12.8 2.6e-31 107.7 12.8 1.8 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EFX06164.1 - 1.1e-23 83.0 7.7 7.6e-06 26.6 0.0 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX06164.1 - 8.6e-11 42.0 0.1 0.042 14.2 0.0 3.8 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFX06164.1 - 4.7e-05 23.4 0.2 0.009 15.9 0.0 2.9 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Arylsulfotran_2 PF14269.6 EFX06164.1 - 6.1e-05 22.5 0.1 0.0023 17.3 0.2 2.6 2 1 1 3 3 3 1 Arylsulfotransferase (ASST) BBS2_Mid PF14783.6 EFX06164.1 - 0.00058 19.9 0.0 4.2 7.5 0.0 4.1 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 EFX06164.1 - 0.00086 17.7 0.0 0.019 13.3 0.0 2.1 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 EFX06164.1 - 0.0015 17.4 0.1 0.52 9.0 0.0 2.5 2 1 0 2 2 2 2 Nup133 N terminal like Ge1_WD40 PF16529.5 EFX06164.1 - 0.015 14.3 0.0 21 4.0 0.0 3.3 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribonuc_red_lgC PF02867.15 EFX06165.1 - 1e-193 644.6 0.0 1.3e-193 644.3 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EFX06165.1 - 2e-23 82.2 0.1 7.1e-23 80.4 0.1 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EFX06165.1 - 9.6e-18 64.5 0.0 1.9e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 ATP cone domain GLTT PF01744.20 EFX06165.1 - 1.8 8.4 4.1 1.2 9.0 0.8 2.5 3 0 0 3 3 3 0 GLTT repeat (6 copies) Ribosomal_L40e PF01020.17 EFX06166.1 - 4.2e-22 77.8 9.2 4.5e-22 77.7 9.2 1.0 1 0 0 1 1 1 1 Ribosomal L40e family zinc_ribbon_2 PF13240.6 EFX06166.1 - 0.028 14.1 2.4 1.1 9.0 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DEAD PF00270.29 EFX06167.1 - 6.9e-45 153.0 0.0 1.4e-44 151.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX06167.1 - 4.1e-23 81.8 0.0 3.2e-22 79.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFX06167.1 - 9.6e-23 80.2 0.1 3.3e-22 78.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFX06167.1 - 2.4e-06 27.7 0.0 1.2e-05 25.4 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Exo5 PF09810.9 EFX06168.1 - 3.7e-130 434.7 0.0 4.3e-130 434.5 0.0 1.0 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EFX06168.1 - 7.5e-05 22.8 0.0 0.72 9.7 0.0 3.2 2 1 0 2 2 2 2 PD-(D/E)XK nuclease superfamily Fungal_trans PF04082.18 EFX06169.1 - 9.9e-31 106.7 0.0 1.9e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06169.1 - 7.4e-07 29.2 12.3 1.4e-06 28.3 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rad10 PF03834.14 EFX06170.1 - 0.063 13.3 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Ras PF00071.22 EFX06172.1 - 5.5e-41 139.9 0.0 1.1e-40 138.9 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFX06172.1 - 9.4e-30 103.3 0.0 1.3e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX06172.1 - 4.9e-11 42.4 0.0 1e-10 41.4 0.0 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX06172.1 - 0.00037 20.5 0.0 0.00055 20.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFX06172.1 - 0.00066 19.1 0.0 0.00084 18.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFX06172.1 - 0.0083 15.7 0.0 0.03 13.9 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EFX06172.1 - 0.013 15.7 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EFX06172.1 - 0.013 14.9 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EFX06172.1 - 0.019 14.7 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EFX06172.1 - 0.037 13.9 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 EFX06172.1 - 0.053 14.0 0.0 0.095 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EFX06172.1 - 0.069 13.1 0.0 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EFX06172.1 - 0.081 13.3 0.0 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EFX06172.1 - 0.096 12.4 2.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EFX06172.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFX06172.1 - 0.23 11.0 0.0 0.36 10.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region CdvA PF18822.1 EFX06174.1 - 0.0084 15.9 1.6 0.014 15.2 1.6 1.3 1 0 0 1 1 1 1 CdvA-like coiled-coil domain Ish1 PF10281.9 EFX06174.1 - 0.051 13.9 0.0 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein HTH_39 PF14090.6 EFX06174.1 - 0.075 12.8 0.4 0.2 11.5 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain bZIP_1 PF00170.21 EFX06174.1 - 0.13 12.3 6.7 0.58 10.3 7.4 1.7 2 1 0 2 2 2 0 bZIP transcription factor TSC22 PF01166.18 EFX06174.1 - 0.42 11.0 2.5 24 5.3 2.5 2.6 1 1 0 1 1 1 0 TSC-22/dip/bun family DAGK_cat PF00781.24 EFX06175.1 - 3e-10 39.8 0.0 1.1e-09 38.0 0.0 1.9 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain MFS_1 PF07690.16 EFX06176.1 - 8.5e-23 80.8 14.4 9.7e-23 80.6 14.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily BLM10_mid PF16507.5 EFX06177.1 - 5.2e-203 675.4 0.0 3.1e-201 669.6 0.0 2.6 3 0 0 3 3 3 2 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EFX06177.1 - 7.4e-22 77.1 0.0 2.3e-21 75.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EFX06177.1 - 1.9e-19 69.7 0.1 4.5e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal HEAT PF02985.22 EFX06177.1 - 0.087 13.1 4.5 6.7 7.3 0.1 4.9 5 0 0 5 5 5 0 HEAT repeat TEA PF01285.18 EFX06178.1 - 1.6e-27 95.4 0.0 4.6e-27 93.9 0.0 1.9 1 0 0 1 1 1 1 TEA/ATTS domain Zip PF02535.22 EFX06178.1 - 5.6 6.1 20.2 0.42 9.8 4.9 2.6 2 0 0 2 2 2 0 ZIP Zinc transporter CPSF100_C PF13299.6 EFX06178.1 - 7.6 6.7 9.1 4.7 7.4 1.5 2.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1308 PF07000.11 EFX06179.1 - 1.7e-08 34.5 0.0 7.2e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) FLILHELTA PF10306.9 EFX06179.1 - 0.083 13.3 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA Iso_dh PF00180.20 EFX06180.1 - 5.6e-97 325.0 0.0 7.6e-97 324.6 0.0 1.2 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CHASE3 PF05227.13 EFX06180.1 - 0.16 11.9 0.4 0.52 10.2 0.4 1.8 1 1 0 1 1 1 0 CHASE3 domain F-box-like PF12937.7 EFX06183.1 - 0.38 10.7 3.6 0.55 10.2 0.0 3.1 4 0 0 4 4 4 0 F-box-like SOBP PF15279.6 EFX06184.1 - 6.8 7.2 9.3 8.9 6.8 9.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein MitMem_reg PF13012.6 EFX06185.1 - 2.7e-36 124.4 0.0 5.6e-36 123.4 0.0 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFX06185.1 - 4.3e-30 104.1 0.0 7.7e-30 103.3 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Transferase PF02458.15 EFX06189.1 - 2.7e-14 52.7 0.0 3.8e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Transferase family Alanine_zipper PF11839.8 EFX06190.1 - 0.0041 17.4 21.1 0.0041 17.4 21.1 4.7 2 1 3 5 5 2 1 Alanine-zipper, major outer membrane lipoprotein Fib_alpha PF08702.10 EFX06190.1 - 0.018 15.2 7.0 0.041 14.1 7.0 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 EFX06190.1 - 0.037 12.0 7.8 0.054 11.4 7.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prominin PF05478.11 EFX06190.1 - 0.045 11.7 6.8 0.061 11.3 6.8 1.2 1 0 0 1 1 1 0 Prominin TMPIT PF07851.13 EFX06190.1 - 0.049 12.9 7.8 0.083 12.1 7.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein CDK5_activator PF03261.15 EFX06190.1 - 0.063 12.8 14.9 0.11 12.0 14.9 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein MIS13 PF08202.11 EFX06190.1 - 0.099 11.9 11.2 0.19 11.0 11.2 1.5 1 0 0 1 1 1 0 Mis12-Mtw1 protein family LMBR1 PF04791.16 EFX06190.1 - 0.17 10.7 5.5 0.24 10.2 5.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein GAS PF13851.6 EFX06190.1 - 0.25 10.6 14.4 0.019 14.3 7.9 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding JIP_LZII PF16471.5 EFX06190.1 - 0.3 11.3 1.8 0.69 10.1 1.8 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II FapA PF03961.13 EFX06190.1 - 0.31 9.6 3.9 0.52 8.8 3.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tweety PF04906.13 EFX06190.1 - 0.35 9.5 12.8 4 6.0 11.1 2.1 2 0 0 2 2 2 0 Tweety BLOC1_2 PF10046.9 EFX06190.1 - 0.42 11.0 9.6 0.91 9.9 9.6 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Miga PF10265.9 EFX06190.1 - 0.85 8.5 0.0 0.85 8.5 0.0 2.9 1 1 2 3 3 2 0 Mitoguardin Fmp27_WPPW PF10359.9 EFX06190.1 - 0.89 8.3 12.4 1.7 7.4 12.4 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4179 PF13786.6 EFX06190.1 - 2.1 8.9 17.2 0.097 13.2 0.4 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4179) DUF2935 PF11155.8 EFX06190.1 - 4 7.8 7.8 7.4 6.9 7.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) 5_nucleotid PF05761.14 EFX06190.1 - 8.5 5.2 7.4 13 4.5 7.4 1.2 1 0 0 1 1 1 0 5' nucleotidase family DUF4200 PF13863.6 EFX06190.1 - 9.4 6.7 17.7 0.16 12.4 7.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) FSH1 PF03959.13 EFX06191.1 - 2.7e-48 164.4 0.0 4.5e-48 163.7 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Frataxin_Cyay PF01491.16 EFX06192.1 - 4.9e-36 123.1 0.0 6.4e-36 122.7 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain Glyco_hydro38C2 PF17677.1 EFX06192.1 - 0.0061 16.6 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain APH PF01636.23 EFX06193.1 - 1.5e-13 51.3 0.2 6e-13 49.3 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Sigma70_ner PF04546.13 EFX06194.1 - 0.014 15.3 0.5 0.03 14.2 0.5 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region TPR_10 PF13374.6 EFX06195.1 - 1.6e-51 170.8 22.5 6.8e-09 35.3 0.0 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 EFX06195.1 - 2.5e-49 165.5 22.8 2.1e-16 59.9 0.1 6.2 3 1 3 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 EFX06195.1 - 5.9e-21 72.9 12.3 0.00022 21.0 0.0 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_4 PF07721.14 EFX06195.1 - 4.7e-17 60.8 0.0 0.17 12.6 0.0 7.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFX06195.1 - 4e-16 58.1 0.3 0.17 11.8 0.0 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFX06195.1 - 2.6e-12 45.9 4.5 1 9.7 0.0 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_3 PF07720.12 EFX06195.1 - 1.2e-11 44.4 10.2 0.11 12.6 0.0 5.8 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFX06195.1 - 5.2e-10 38.7 6.2 3.2 8.2 0.0 6.7 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EFX06195.1 - 2.6e-09 36.9 4.9 1.6e-08 34.3 1.5 2.6 1 1 1 2 2 2 2 MalT-like TPR region TPR_17 PF13431.6 EFX06195.1 - 4.4e-07 29.8 2.7 12 6.6 0.0 6.2 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFX06195.1 - 5.1e-07 30.1 3.6 0.4 11.2 0.0 6.2 5 1 2 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX06195.1 - 2.4e-06 28.1 6.9 0.022 15.4 0.1 6.4 5 2 0 5 5 5 1 Tetratricopeptide repeat AAA_22 PF13401.6 EFX06195.1 - 3.4e-06 27.4 0.0 1.4e-05 25.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain TPR_20 PF14561.6 EFX06195.1 - 0.00035 20.8 1.5 22 5.5 0.0 5.4 2 2 3 5 5 5 0 Tetratricopeptide repeat NB-ARC PF00931.22 EFX06195.1 - 0.00037 19.8 0.0 0.00074 18.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ANAPC3 PF12895.7 EFX06195.1 - 0.015 15.5 2.2 36 4.7 0.1 4.9 4 1 0 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 AAA_16 PF13191.6 EFX06195.1 - 0.027 14.9 0.3 0.14 12.6 0.3 2.3 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 EFX06195.1 - 0.029 13.8 0.0 0.08 12.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein Pro_3_hydrox_C PF05373.11 EFX06195.1 - 0.051 13.7 0.3 0.14 12.2 0.3 1.8 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal TPR_14 PF13428.6 EFX06195.1 - 0.33 11.9 13.9 59 4.9 0.0 7.3 7 1 1 8 8 7 0 Tetratricopeptide repeat CLN3 PF02487.17 EFX06196.1 - 5.7e-157 522.9 4.1 6.7e-157 522.6 4.1 1.0 1 0 0 1 1 1 1 CLN3 protein ADK PF00406.22 EFX06198.1 - 1.9e-58 196.9 0.0 2.4e-58 196.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFX06198.1 - 3.8e-23 82.4 0.1 8.4e-23 81.3 0.0 1.6 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 EFX06198.1 - 1.8e-17 63.0 0.0 7.9e-17 61.0 0.0 2.1 3 0 0 3 3 3 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EFX06198.1 - 7e-05 23.4 0.0 0.00014 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFX06198.1 - 0.00015 21.9 0.0 0.00028 21.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFX06198.1 - 0.16 11.6 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase Ysc84 PF04366.12 EFX06199.1 - 2.3e-48 163.2 0.4 3.9e-48 162.4 0.4 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator TERB2 PF15101.6 EFX06199.1 - 0.13 12.3 6.4 0.25 11.4 6.4 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TFIIA PF03153.13 EFX06199.1 - 0.19 11.7 24.3 0.017 15.2 19.3 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 EFX06199.1 - 0.32 9.9 7.9 0.46 9.4 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 EFX06199.1 - 0.87 9.1 31.9 0.5 9.9 27.8 2.0 2 0 0 2 2 2 0 Spt20 family Nro1 PF12753.7 EFX06199.1 - 0.98 8.3 4.1 1.5 7.7 4.1 1.1 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 CPSF100_C PF13299.6 EFX06199.1 - 1.3 9.2 4.4 0.76 9.9 1.6 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.6 EFX06199.1 - 7.7 4.3 23.1 12 3.6 23.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Fungal_trans_2 PF11951.8 EFX06200.1 - 2.3e-14 53.1 0.1 8.6e-09 34.7 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06200.1 - 1.4e-08 34.7 11.0 2.5e-08 33.9 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DLEU7 PF15760.5 EFX06200.1 - 0.2 11.1 2.2 0.48 9.9 2.2 1.6 1 0 0 1 1 1 0 Leukemia-associated protein 7 DUF3498 PF12004.8 EFX06201.1 - 2.5 7.2 6.3 4.9 6.2 6.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) SelP_N PF04592.14 EFX06201.1 - 3.8 6.9 13.5 7.8 5.8 13.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Amidohydro_3 PF07969.11 EFX06202.1 - 6.2e-16 58.9 0.7 1.2e-08 34.9 0.1 3.2 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 EFX06202.1 - 3.2e-12 46.4 0.1 3.3e-08 33.2 0.1 2.4 2 0 0 2 2 2 2 Amidohydrolase family TPR_12 PF13424.6 EFX06203.1 - 7.7e-37 125.5 16.2 6.8e-15 55.1 1.6 5.6 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 EFX06203.1 - 2.4e-32 109.9 8.6 1e-10 41.1 0.1 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat Ank_2 PF12796.7 EFX06203.1 - 1.3e-31 109.0 7.9 3.3e-14 53.2 0.6 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EFX06203.1 - 1.5e-16 60.0 6.7 1e-06 28.9 0.4 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFX06203.1 - 2.8e-15 56.4 3.3 3.1e-05 24.4 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX06203.1 - 2.3e-13 50.1 6.7 9.9e-05 22.6 0.1 4.6 2 1 3 5 5 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06203.1 - 4.8e-13 48.0 1.7 0.015 15.8 0.1 5.0 5 0 0 5 5 4 3 Ankyrin repeat TPR_7 PF13176.6 EFX06203.1 - 5e-08 32.4 6.6 0.22 11.6 0.1 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFX06203.1 - 2e-07 30.6 6.2 0.15 12.2 0.3 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX06203.1 - 5e-07 29.3 6.5 0.076 12.9 0.5 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFX06203.1 - 6.3e-05 23.4 6.2 0.42 11.1 0.2 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFX06203.1 - 0.0014 19.2 3.4 2.7 8.7 0.0 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFX06203.1 - 0.0018 18.5 3.3 0.36 11.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 EFX06203.1 - 0.01 16.3 2.6 5.9 7.8 0.1 3.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX06203.1 - 0.02 15.1 5.0 5.5 7.5 0.6 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Ndc1_Nup PF09531.10 EFX06204.1 - 2e-184 614.8 4.1 2.2e-184 614.6 4.1 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup MFS_1 PF07690.16 EFX06205.1 - 9e-32 110.4 35.1 9e-32 110.4 35.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EFX06205.1 - 9.3e-06 24.3 3.0 9.3e-06 24.3 3.0 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) RIBIOP_C PF04950.12 EFX06206.1 - 1.1e-104 350.0 0.0 1.8e-104 349.2 0.0 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFX06206.1 - 2.9e-19 68.9 0.0 7.9e-19 67.5 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Ima1_N PF09779.9 EFX06207.1 - 4e-38 131.3 4.6 7.5e-38 130.4 4.6 1.5 1 0 0 1 1 1 1 Ima1 N-terminal domain DZR PF12773.7 EFX06207.1 - 0.7 10.0 5.5 3.2 7.8 0.4 2.5 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EFX06207.1 - 1.4 8.4 4.4 28 4.3 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Gcd10p PF04189.13 EFX06208.1 - 1.5e-119 398.6 0.0 1.8e-119 398.3 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family rRNA_proc-arch PF13234.6 EFX06209.1 - 2.4e-91 306.4 2.5 5.9e-91 305.1 0.0 2.6 3 0 0 3 3 3 1 rRNA-processing arch domain DSHCT PF08148.12 EFX06209.1 - 7.8e-48 162.2 2.8 1.4e-47 161.4 1.9 1.9 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EFX06209.1 - 5.6e-18 65.3 0.0 1.3e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX06209.1 - 1.8e-06 28.2 0.1 1.4e-05 25.4 0.1 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX06209.1 - 1.9e-05 24.7 0.0 6.4e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EFX06209.1 - 0.061 12.4 0.0 0.17 10.9 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 EFX06209.1 - 0.15 12.4 0.0 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AA_permease_2 PF13520.6 EFX06210.1 - 1.5e-60 205.2 55.6 1.9e-60 204.9 55.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EFX06210.1 - 5.8e-26 91.1 46.4 7.9e-26 90.7 46.4 1.1 1 0 0 1 1 1 1 Amino acid permease Aldedh PF00171.22 EFX06211.1 - 2.7e-186 619.6 0.1 3.1e-186 619.4 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EFX06211.1 - 0.11 11.9 0.0 1.2 8.5 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) Ank_2 PF12796.7 EFX06213.1 - 6.5e-70 231.8 2.5 9.2e-19 67.8 0.1 5.7 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX06213.1 - 4.4e-56 186.6 3.7 6.2e-12 45.8 0.1 7.2 5 2 1 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06213.1 - 3.5e-53 171.4 6.6 2.4e-05 24.4 0.0 11.2 11 0 0 11 11 11 11 Ankyrin repeat Ank PF00023.30 EFX06213.1 - 1.9e-51 170.3 16.2 2.9e-05 24.3 0.0 11.1 10 1 1 11 11 11 10 Ankyrin repeat Ank_5 PF13857.6 EFX06213.1 - 1.4e-42 143.2 12.9 4.5e-07 30.0 0.0 10.7 2 2 9 11 11 11 11 Ankyrin repeats (many copies) Plectin PF00681.20 EFX06213.1 - 6.7e-05 22.7 0.0 3.7 7.5 0.0 4.7 5 0 0 5 5 5 2 Plectin repeat DUF1843 PF08898.10 EFX06213.1 - 0.029 14.9 8.0 14 6.2 0.7 5.0 5 1 0 5 5 5 0 Domain of unknown function (DUF1843) NICE-3 PF07406.11 EFX06214.1 - 0.0065 16.5 0.1 2.5 8.1 0.1 2.4 2 0 0 2 2 2 2 NICE-3 protein DUF4129 PF13559.6 EFX06214.1 - 0.048 13.9 0.0 0.16 12.3 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) adh_short PF00106.25 EFX06215.1 - 1.1e-30 106.6 0.0 1.6e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX06215.1 - 1.5e-24 86.9 0.1 2.2e-24 86.3 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFX06215.1 - 0.057 12.9 0.1 0.21 11.0 0.0 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family KR PF08659.10 EFX06215.1 - 0.09 12.7 0.4 0.25 11.2 0.4 1.7 1 1 0 1 1 1 0 KR domain 3Beta_HSD PF01073.19 EFX06215.1 - 0.13 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HSP70 PF00012.20 EFX06216.1 - 1.2e-57 195.5 23.3 1.5e-57 195.1 0.1 3.1 3 0 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 EFX06216.1 - 0.0015 17.4 0.2 0.0093 14.8 0.2 2.2 1 1 0 1 1 1 1 MreB/Mbl protein HHH_8 PF14716.6 EFX06216.1 - 0.032 14.6 2.0 3.7 8.0 0.0 3.0 3 0 0 3 3 3 0 Helix-hairpin-helix domain Peptidase_M22 PF00814.25 EFX06216.1 - 0.046 13.4 0.3 0.27 10.9 0.2 2.2 2 0 0 2 2 2 0 Glycoprotease family DUF3484 PF11983.8 EFX06216.1 - 2.2 9.5 4.3 3.5 8.8 0.0 3.4 3 1 0 3 3 3 0 Membrane-attachment and polymerisation-promoting switch bZIP_1 PF00170.21 EFX06217.1 - 1e-08 35.1 10.3 1e-08 35.1 10.3 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFX06217.1 - 0.018 15.1 10.0 0.018 15.1 10.0 2.5 2 0 0 2 2 2 0 Basic region leucine zipper TFIIA PF03153.13 EFX06217.1 - 1.2 9.1 40.9 0.61 10.0 34.4 2.4 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 EFX06217.1 - 1.9 8.3 19.8 0.41 10.5 0.7 2.6 2 0 0 2 2 2 0 Septum formation initiator tRNA_U5-meth_tr PF05958.11 EFX06218.1 - 4.5e-09 35.7 0.0 6.2e-08 32.0 0.0 2.4 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 EFX06218.1 - 4.7e-05 24.0 0.0 0.00011 22.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX06218.1 - 9e-05 22.3 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFX06218.1 - 0.0037 16.7 0.1 0.0066 15.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EFX06218.1 - 0.018 14.7 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 EFX06218.1 - 0.021 15.5 0.0 0.052 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.22 EFX06219.1 - 9.2e-48 161.9 0.0 1.2e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX06219.1 - 5.2e-20 71.9 0.0 1.1e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX06219.1 - 2.3e-05 23.9 0.0 5.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EFX06219.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ThiF PF00899.21 EFX06220.1 - 6.8e-71 238.5 0.1 9.9e-71 237.9 0.1 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EFX06220.1 - 1.6e-23 83.1 2.9 8.1e-23 80.8 0.3 2.7 3 0 0 3 3 3 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EFX06220.1 - 2.9e-06 27.4 0.1 0.00066 19.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EFX06220.1 - 0.0021 18.5 0.4 0.0067 16.9 0.1 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFX06220.1 - 0.0041 17.2 0.3 0.022 14.8 0.1 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 EFX06220.1 - 0.031 13.5 0.1 0.082 12.1 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX06220.1 - 0.1 13.2 0.1 0.44 11.1 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FeoA PF04023.14 EFX06220.1 - 0.11 12.7 0.0 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 FeoA domain Snf7 PF03357.21 EFX06221.1 - 6.8e-43 146.2 3.0 7.7e-43 146.1 3.0 1.1 1 0 0 1 1 1 1 Snf7 CLZ PF16526.5 EFX06221.1 - 8.4e-05 22.9 4.6 0.16 12.4 0.0 3.7 2 1 1 3 3 3 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 EFX06221.1 - 0.00038 20.9 4.3 0.036 14.5 1.8 2.9 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF848 PF05852.11 EFX06221.1 - 0.0028 17.8 5.0 0.0052 16.9 5.0 1.5 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) Wtap PF17098.5 EFX06221.1 - 0.0033 17.4 7.6 0.01 15.7 7.6 1.7 1 1 0 1 1 1 1 WTAP/Mum2p family DUF3584 PF12128.8 EFX06221.1 - 0.0092 13.6 7.3 0.013 13.1 7.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) THF_DHG_CYH PF00763.23 EFX06221.1 - 0.026 14.8 0.3 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain FlaC_arch PF05377.11 EFX06221.1 - 0.056 13.9 5.4 16 6.0 0.0 3.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4201 PF13870.6 EFX06221.1 - 0.11 12.3 9.4 0.11 12.3 6.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF2205 PF10224.9 EFX06221.1 - 0.12 12.4 6.5 0.061 13.3 2.0 2.5 1 1 1 2 2 2 0 Short coiled-coil protein Cob_adeno_trans PF01923.18 EFX06221.1 - 0.27 11.4 3.7 12 6.0 3.7 2.1 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Prominin PF05478.11 EFX06221.1 - 0.32 8.9 2.1 0.38 8.7 2.1 1.2 1 0 0 1 1 1 0 Prominin YabA PF06156.13 EFX06221.1 - 0.46 11.1 6.9 3.2 8.5 5.4 2.4 1 1 1 2 2 2 0 Initiation control protein YabA FlxA PF14282.6 EFX06221.1 - 0.64 10.0 8.7 0.29 11.1 5.9 1.8 1 1 1 2 2 2 0 FlxA-like protein DUF2730 PF10805.8 EFX06221.1 - 0.67 10.1 8.9 1.7 8.8 3.6 3.0 1 1 3 4 4 4 0 Protein of unknown function (DUF2730) FapA PF03961.13 EFX06221.1 - 0.9 8.1 6.7 3.5 6.1 0.5 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A BLOC1_2 PF10046.9 EFX06221.1 - 1.1 9.7 8.8 1.5 9.2 3.4 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 EFX06221.1 - 1.6 9.1 4.0 4.5 7.6 1.3 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) NYD-SP28_assoc PF14775.6 EFX06221.1 - 1.6 8.9 6.8 25 5.1 0.1 2.7 1 1 1 2 2 2 0 Sperm tail C-terminal domain TMPIT PF07851.13 EFX06221.1 - 1.8 7.8 5.8 2.7 7.1 5.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein p450 PF00067.22 EFX06222.1 - 2e-33 115.8 0.0 1.6e-31 109.6 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.16 EFX06223.1 - 2.4e-37 128.7 29.2 2.4e-37 128.7 29.2 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Ilm1 PF10311.9 EFX06223.1 - 0.059 13.0 0.3 12 5.5 0.1 2.7 1 1 1 2 2 2 0 Increased loss of mitochondrial DNA protein 1 MWFE PF15879.5 EFX06223.1 - 0.089 13.0 0.0 0.48 10.6 0.0 2.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase MWFE subunit MFS_1 PF07690.16 EFX06224.1 - 3.3e-16 59.2 27.4 6.6e-16 58.2 27.4 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EFX06224.1 - 3.1e-11 43.2 7.7 6.1e-11 42.3 6.5 2.1 1 1 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1_like PF12832.7 EFX06224.1 - 1.4e-05 24.1 5.0 1.4e-05 24.1 5.0 1.8 2 0 0 2 2 2 1 MFS_1 like family PUCC PF03209.15 EFX06224.1 - 0.088 11.8 14.5 0.024 13.6 7.0 2.9 3 0 0 3 3 3 0 PUCC protein Sugar_tr PF00083.24 EFX06224.1 - 0.18 10.6 21.3 0.0069 15.3 10.4 2.8 3 0 0 3 3 3 0 Sugar (and other) transporter EutQ PF06249.12 EFX06225.1 - 5.5e-11 42.5 0.0 6.5e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 EFX06225.1 - 3.4e-10 39.5 0.0 5.1e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 EFX06225.1 - 1.5e-05 24.6 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EFX06225.1 - 0.015 15.0 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_1 PF00190.22 EFX06225.1 - 0.016 14.8 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Cupin AraC_binding PF02311.19 EFX06225.1 - 0.066 13.1 0.0 0.088 12.7 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain Pirin PF02678.16 EFX06225.1 - 0.076 13.0 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Pirin adh_short_C2 PF13561.6 EFX06226.1 - 1.1e-50 172.4 4.8 1.3e-50 172.2 4.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX06226.1 - 2.4e-42 144.6 3.0 2.9e-42 144.3 3.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX06226.1 - 2.6e-09 37.2 0.4 3.8e-09 36.7 0.4 1.2 1 0 0 1 1 1 1 KR domain Dak1_2 PF13684.6 EFX06226.1 - 0.02 14.0 0.1 0.03 13.4 0.1 1.3 1 0 0 1 1 1 0 Dihydroxyacetone kinase family R3H PF01424.22 EFX06227.1 - 1.6e-10 40.8 0.1 3.3e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EFX06227.1 - 0.0033 17.2 0.1 0.0097 15.7 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) K_channel_TID PF07941.11 EFX06227.1 - 3 8.4 6.4 11 6.5 0.8 3.4 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain CtaG_Cox11 PF04442.14 EFX06228.1 - 3.3e-58 196.0 0.0 7.2e-58 194.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Amino_oxidase PF01593.24 EFX06228.1 - 1.5e-16 60.8 0.1 6.5e-16 58.7 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFX06228.1 - 3.2e-12 46.5 0.1 8.7e-12 45.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX06228.1 - 0.00059 19.5 1.6 0.0091 15.6 0.6 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX06228.1 - 0.0006 19.8 0.0 1.7 8.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFX06228.1 - 0.011 14.9 0.0 0.042 13.1 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFX06228.1 - 0.041 13.2 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EFX06228.1 - 0.056 12.1 0.0 1 8.0 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EFX06228.1 - 0.092 13.3 0.0 0.41 11.3 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Acetyltransf_8 PF13523.6 EFX06230.1 - 2.7e-39 134.2 0.1 4.6e-39 133.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MCU PF04678.13 EFX06230.1 - 2e-22 80.2 0.4 3.2e-22 79.5 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Spt20 PF12090.8 EFX06232.1 - 4.1e-45 154.2 0.0 4.1e-45 154.2 0.0 3.8 2 1 1 3 3 3 1 Spt20 family RIFIN PF02009.16 EFX06232.1 - 1.3 8.8 4.0 3.2 7.6 4.0 1.6 1 0 0 1 1 1 0 Rifin WDCP PF15390.6 EFX06232.1 - 7.8 4.7 6.8 12 4.1 6.3 1.4 1 1 0 1 1 1 0 WD repeat and coiled-coil-containing protein family GREB1 PF15782.5 EFX06232.1 - 9.1 3.3 18.5 13 2.7 18.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Fungal_trans PF04082.18 EFX06233.1 - 1.4e-07 30.8 0.0 2.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06233.1 - 0.00011 22.3 17.7 0.00022 21.3 17.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lectin_leg-like PF03388.13 EFX06233.1 - 0.16 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Legume-like lectin family MDD_C PF18376.1 EFX06234.1 - 1.7e-62 210.5 0.1 2.7e-62 209.9 0.1 1.3 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain PNK3P PF08645.11 EFX06234.1 - 7.3e-50 168.8 0.0 2.2e-49 167.3 0.0 1.9 1 1 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EFX06234.1 - 6.6e-23 81.5 0.0 1.6e-20 73.7 0.0 2.7 1 1 0 1 1 1 1 AAA domain GHMP_kinases_N PF00288.26 EFX06234.1 - 3.5e-08 33.6 0.8 3.5e-08 33.6 0.8 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain PTH2 PF01981.16 EFX06235.1 - 5.3e-38 129.9 0.1 7.1e-38 129.5 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 S10_plectin PF03501.15 EFX06236.1 - 6.7e-38 128.7 0.1 8.2e-38 128.4 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF5549 PF17703.1 EFX06236.1 - 4.8 6.8 9.4 7 6.3 9.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5549) Pro-kuma_activ PF09286.11 EFX06237.1 - 6.5e-45 152.9 0.0 1.9e-44 151.4 0.0 1.8 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain ChpXY PF10216.9 EFX06239.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 CO2 hydration protein (ChpXY) BTB_2 PF02214.22 EFX06241.1 - 2.9e-05 24.3 0.0 0.0026 18.1 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain RabGAP-TBC PF00566.18 EFX06242.1 - 3.7e-48 164.0 0.1 2.3e-47 161.5 0.1 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Cnn_1N PF07989.11 EFX06242.1 - 0.00022 21.3 5.5 0.00022 21.3 5.5 2.8 1 1 1 2 2 2 1 Centrosomin N-terminal motif 1 HALZ PF02183.18 EFX06242.1 - 0.1 12.8 0.3 0.1 12.8 0.3 3.3 4 0 0 4 4 4 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 EFX06242.1 - 1.4 9.4 8.0 5.1 7.6 0.7 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) YabA PF06156.13 EFX06242.1 - 2.1 9.0 11.2 1.9e+02 2.7 11.1 2.8 1 1 0 1 1 1 0 Initiation control protein YabA ADIP PF11559.8 EFX06242.1 - 4 7.5 24.3 1.4 9.0 8.9 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Mod_r PF07200.13 EFX06242.1 - 4.5 7.4 18.0 2.2 8.4 6.5 2.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein OrsD PF12013.8 EFX06244.1 - 0.22 12.0 4.8 0.44 11.0 4.8 1.5 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D Histone PF00125.24 EFX06245.1 - 2.1e-18 66.9 0.0 2.7e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EFX06245.1 - 8.2e-13 47.8 0.1 2.1e-12 46.6 0.1 1.7 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EFX06245.1 - 2.8e-05 24.3 0.0 4.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Macoilin PF09726.9 EFX06247.1 - 1.6 7.2 9.4 0.11 11.1 2.9 1.9 2 0 0 2 2 2 0 Macoilin family Phage_H_T_join PF05521.11 EFX06247.1 - 8.3 7.0 8.3 1.3 9.5 0.3 3.3 3 0 0 3 3 3 0 Phage head-tail joining protein Methyltransf_25 PF13649.6 EFX06248.1 - 2.5e-25 89.0 0.0 3.8e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06248.1 - 4.2e-24 85.0 0.0 6.6e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX06248.1 - 1.2e-23 83.6 0.0 1.5e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX06248.1 - 1.2e-15 58.1 0.0 1.9e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX06248.1 - 1e-13 51.1 0.0 1.9e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFX06248.1 - 2e-13 50.5 0.0 3.2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFX06248.1 - 2.1e-09 37.2 0.0 3.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EFX06248.1 - 1.2e-08 34.9 0.0 1.9e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EFX06248.1 - 5.2e-06 26.0 0.0 2.4e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 Putative methyltransferase NodS PF05401.11 EFX06248.1 - 8e-06 25.6 0.0 1.8e-05 24.5 0.0 1.5 1 1 1 2 2 2 1 Nodulation protein S (NodS) CMAS PF02353.20 EFX06248.1 - 3.3e-05 23.3 0.0 4.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DUF938 PF06080.12 EFX06248.1 - 0.00015 21.6 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltr_RsmB-F PF01189.17 EFX06248.1 - 0.00058 19.5 0.0 0.00091 18.9 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_32 PF13679.6 EFX06248.1 - 0.0024 17.9 0.0 0.0037 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EFX06248.1 - 0.0026 17.9 0.0 0.0044 17.1 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.16 EFX06248.1 - 0.0027 16.3 0.0 0.0049 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CheR PF01739.18 EFX06248.1 - 0.0035 16.9 0.0 0.094 12.2 0.0 2.1 1 1 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_24 PF13578.6 EFX06248.1 - 0.013 16.5 0.0 0.2 12.7 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 EFX06248.1 - 0.02 14.5 0.0 0.05 13.2 0.0 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.7 EFX06248.1 - 0.022 14.7 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 EFX06248.1 - 0.027 13.7 0.1 0.038 13.3 0.1 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_8 PF05148.15 EFX06248.1 - 0.11 12.3 0.0 0.67 9.8 0.0 1.9 1 1 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_9 PF08003.11 EFX06248.1 - 0.11 11.4 0.0 0.23 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) RrnaAD PF00398.20 EFX06248.1 - 0.21 10.6 0.0 0.3 10.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PAP2 PF01569.21 EFX06249.1 - 1.6e-20 73.3 2.4 4.3e-20 71.9 2.4 1.8 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EFX06249.1 - 0.0014 18.4 2.2 0.0041 16.8 2.2 2.0 1 0 0 1 1 1 1 PAP2 superfamily WD40 PF00400.32 EFX06250.1 - 7.7e-27 93.0 9.2 0.00055 20.7 0.1 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 EFX06250.1 - 7.3e-12 45.0 3.5 1.5e-11 44.0 3.5 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EFX06250.1 - 8.5e-07 29.2 0.2 0.46 10.8 0.0 3.9 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EFX06250.1 - 1.7e-06 27.7 0.5 5.2e-06 26.2 0.5 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EFX06250.1 - 0.0095 14.6 0.7 3.8 6.0 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 DUF5593 PF18007.1 EFX06250.1 - 2.1 9.1 9.3 5.2 7.8 0.8 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5593) GHL15 PF14885.6 EFX06251.1 - 0.05 13.6 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 HbrB PF08539.11 EFX06252.1 - 1.8e-51 174.5 0.0 1.8e-51 174.5 0.0 3.5 3 0 0 3 3 3 1 HbrB-like Vps39_2 PF10367.9 EFX06252.1 - 3.5e-25 88.6 2.5 4.1e-24 85.1 0.0 2.8 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EFX06252.1 - 3.6e-19 69.0 0.0 3.6e-19 69.0 0.0 3.7 3 1 1 4 4 4 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 EFX06252.1 - 0.00082 19.1 0.0 0.002 17.8 0.0 1.6 1 0 0 1 1 1 1 CNH domain FHIPEP PF00771.20 EFX06252.1 - 9.9 4.5 12.1 11 4.3 10.2 2.0 2 0 0 2 2 2 0 FHIPEP family Glycos_transf_1 PF00534.20 EFX06253.1 - 8.3e-29 100.3 0.0 1.2e-27 96.6 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFX06253.1 - 1.7e-13 51.2 0.1 5e-13 49.6 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFX06253.1 - 5.3e-11 42.8 1.8 5.2e-10 39.6 1.8 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EFX06253.1 - 0.0001 22.8 9.5 0.0001 22.8 9.5 2.8 2 2 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EFX06253.1 - 0.027 14.8 0.2 0.14 12.5 0.2 2.0 1 1 0 1 1 1 0 Glycosyl transferases group 1 ALG11_N PF15924.5 EFX06253.1 - 0.26 11.3 0.1 11 6.0 0.0 2.2 2 0 0 2 2 2 0 ALG11 mannosyltransferase N-terminus DBR1 PF05011.13 EFX06254.1 - 3.5e-47 160.3 0.0 5.4e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EFX06254.1 - 0.00011 22.8 0.5 0.00041 20.9 0.2 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase MatE PF01554.18 EFX06256.1 - 1.3e-46 158.2 34.2 9.7e-32 109.8 10.4 2.5 3 0 0 3 3 3 2 MatE Como_SCP PF02248.16 EFX06256.1 - 0.3 10.7 1.4 0.29 10.7 0.2 1.5 2 0 0 2 2 2 0 Small coat protein Polysacc_synt_C PF14667.6 EFX06256.1 - 5.5 7.0 35.5 0.049 13.7 13.1 4.2 1 1 1 3 3 3 0 Polysaccharide biosynthesis C-terminal domain DNA_pol_delta_4 PF04081.13 EFX06257.1 - 4.6e-35 120.8 5.4 2.9e-34 118.2 5.4 1.9 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 OB_NTP_bind PF07717.16 EFX06258.1 - 3.5e-21 75.4 0.0 7.7e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFX06258.1 - 1.5e-18 67.1 0.0 3.9e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFX06258.1 - 2.9e-10 40.4 0.0 2e-09 37.8 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFX06258.1 - 8.2e-07 29.4 0.0 2.2e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EFX06258.1 - 7.8e-06 25.8 0.1 1.6e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EFX06258.1 - 0.0016 18.2 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFX06258.1 - 0.0029 17.3 0.0 0.007 16.0 0.0 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_23 PF13476.6 EFX06258.1 - 0.0056 17.2 0.0 0.01 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFX06258.1 - 0.012 15.9 0.0 0.034 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFX06258.1 - 0.056 12.5 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 EFX06258.1 - 0.061 13.3 0.1 8.1 6.4 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 EFX06258.1 - 0.11 12.0 0.1 0.47 10.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Tubulin PF00091.25 EFX06260.1 - 2.6e-67 226.9 0.0 3.7e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFX06260.1 - 6.3e-50 168.6 0.1 1e-49 167.9 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFX06260.1 - 0.0026 17.5 0.0 0.0073 16.0 0.0 1.7 2 0 0 2 2 2 1 Tubulin domain ATG22 PF11700.8 EFX06261.1 - 6.7e-130 433.9 28.7 7.9e-130 433.7 28.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EFX06261.1 - 8.6e-09 34.8 33.1 0.00054 19.0 8.3 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF5056 PF16479.5 EFX06261.1 - 0.077 13.2 0.0 0.28 11.5 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) Pkinase PF00069.25 EFX06262.1 - 1.5e-48 165.5 0.0 1.9e-48 165.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX06262.1 - 5.9e-38 130.6 0.0 8.2e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFX06262.1 - 0.0005 19.0 0.0 0.0018 17.1 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFX06262.1 - 0.017 14.4 0.0 0.055 12.8 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EFX06262.1 - 0.044 12.7 0.0 0.89 8.4 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EFX06262.1 - 0.14 11.5 0.0 0.33 10.3 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aldo_ket_red PF00248.21 EFX06263.1 - 7e-76 255.2 0.0 7.9e-76 255.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CENP-X PF09415.10 EFX06264.1 - 3.2e-22 78.6 0.0 3.2e-22 78.6 0.0 2.1 2 1 0 2 2 2 1 CENP-S associating Centromere protein X Ald_Xan_dh_C2 PF02738.18 EFX06265.1 - 1.6e-200 667.2 1.2 2.4e-200 666.7 1.2 1.3 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EFX06265.1 - 3.8e-43 147.2 0.0 7.9e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EFX06265.1 - 1.1e-33 115.5 2.3 3.8e-32 110.5 0.1 2.8 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EFX06265.1 - 5.2e-30 103.3 0.1 1.4e-29 101.9 0.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.22 EFX06265.1 - 1.6e-28 99.3 0.8 5.8e-28 97.5 0.3 2.2 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.27 EFX06265.1 - 1.5e-07 31.3 0.1 1.5e-07 31.3 0.1 3.0 2 1 1 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 EFX06265.1 - 0.075 13.0 0.1 0.24 11.4 0.1 1.8 1 0 0 1 1 1 0 DUF218 domain DUF1741 PF08427.10 EFX06266.1 - 5.9e-67 225.7 1.5 3.7e-58 197.0 0.2 2.6 2 1 1 3 3 3 2 Domain of unknown function (DUF1741) Thiolase_N PF00108.23 EFX06267.1 - 2.3e-16 59.9 0.0 1.1e-15 57.8 0.0 2.0 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFX06267.1 - 2.4e-10 40.1 0.2 2.3e-09 37.0 0.2 2.6 1 1 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EFX06267.1 - 0.00029 20.6 0.1 0.015 15.1 0.0 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 EFX06267.1 - 0.001 19.1 2.1 0.058 13.4 0.0 3.5 4 0 0 4 4 4 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 EFX06267.1 - 0.0059 16.2 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 EFX06267.1 - 0.071 11.8 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) SNAP PF14938.6 EFX06269.1 - 4.6e-113 377.3 17.7 5.2e-113 377.2 17.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFX06269.1 - 4.9e-10 39.5 12.0 0.00034 20.8 0.5 3.4 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFX06269.1 - 8e-08 31.8 21.1 0.48 10.7 0.0 6.9 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFX06269.1 - 9.2e-07 28.6 13.9 0.19 12.0 0.1 5.5 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFX06269.1 - 2.2e-06 27.9 8.8 0.067 13.9 0.0 5.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFX06269.1 - 2.8e-05 24.6 13.1 5.9 8.0 0.1 6.2 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFX06269.1 - 0.00026 20.7 15.5 4.1 7.4 0.4 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat RPN7 PF10602.9 EFX06269.1 - 0.0024 17.6 3.3 0.5 10.1 0.1 3.3 1 1 3 4 4 4 2 26S proteasome subunit RPN7 TPR_7 PF13176.6 EFX06269.1 - 0.0054 16.7 7.3 1.8 8.8 0.1 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat PhageMin_Tail PF10145.9 EFX06269.1 - 0.013 15.3 1.1 0.037 13.9 0.4 2.0 2 0 0 2 2 2 0 Phage-related minor tail protein BTAD PF03704.17 EFX06269.1 - 0.033 14.6 1.7 1 9.8 0.2 2.7 1 1 1 2 2 2 0 Bacterial transcriptional activator domain HemY_N PF07219.13 EFX06269.1 - 0.11 12.7 7.4 0.29 11.3 0.0 3.5 2 1 3 5 5 5 0 HemY protein N-terminus TPR_19 PF14559.6 EFX06269.1 - 0.3 11.6 14.4 0.49 10.9 0.4 4.5 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFX06269.1 - 2.1 9.1 20.5 1.5 9.5 1.4 5.7 2 1 3 5 5 5 0 Tetratricopeptide repeat Ctr PF04145.15 EFX06270.1 - 1.7e-26 93.6 6.0 4e-26 92.4 6.0 1.6 1 1 0 1 1 1 1 Ctr copper transporter family Oxidored_q3 PF00499.20 EFX06270.1 - 3.5 7.3 12.1 1.1 8.9 7.9 1.9 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 ALG11_N PF15924.5 EFX06272.1 - 6.6e-83 277.9 0.0 9.3e-83 277.4 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EFX06272.1 - 1.4e-24 86.6 0.0 2.2e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFX06272.1 - 1.4e-11 44.9 0.0 4e-11 43.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFX06272.1 - 0.0051 16.8 0.1 0.015 15.3 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Phage_P2_GpE PF06528.12 EFX06272.1 - 0.016 14.7 2.3 0.32 10.6 0.2 2.9 2 0 0 2 2 2 0 Phage P2 GpE Glu-tRNAGln PF02686.15 EFX06273.1 - 5.3e-06 26.6 0.0 1.8e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Creb_binding PF09030.10 EFX06273.1 - 0.27 12.0 0.2 0.27 12.0 0.2 1.8 2 0 0 2 2 2 0 Creb binding SART-1 PF03343.13 EFX06274.1 - 8.5e-165 549.9 47.2 1e-164 549.6 47.2 1.0 1 0 0 1 1 1 1 SART-1 family Fungal_trans PF04082.18 EFX06275.1 - 4.8e-16 58.6 0.0 9.3e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3632 PF12311.8 EFX06276.1 - 3.2e-37 128.6 1.1 5e-37 128.0 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) DEAD PF00270.29 EFX06278.1 - 0.072 12.8 0.0 0.097 12.4 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase FUSC-like PF12805.7 EFX06279.1 - 0.49 9.4 2.1 0.78 8.8 0.5 1.9 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS Fungal_trans PF04082.18 EFX06280.1 - 1e-27 96.9 0.2 2.4e-27 95.6 0.2 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06280.1 - 3.2e-08 33.5 13.4 3.2e-08 33.5 13.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 EFX06280.1 - 0.15 12.2 0.1 0.15 12.2 0.1 3.4 3 2 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TSC22 PF01166.18 EFX06280.1 - 8.2 6.8 5.9 0.45 10.9 0.1 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family AIP3 PF03915.13 EFX06281.1 - 1.6e-148 495.2 9.9 2.7e-148 494.4 9.9 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 DUF1664 PF07889.12 EFX06281.1 - 0.00012 22.1 7.0 0.2 11.7 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 EFX06281.1 - 0.09 12.9 5.0 0.93 9.6 0.4 3.2 3 0 0 3 3 3 0 RasGAP C-terminus Baculo_PEP_C PF04513.12 EFX06281.1 - 0.098 12.7 9.0 0.71 9.9 1.0 3.6 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 EFX06281.1 - 0.18 12.3 7.1 0.34 11.4 0.2 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Occludin_ELL PF07303.13 EFX06281.1 - 0.25 12.1 1.8 35 5.2 0.2 3.0 2 0 0 2 2 2 0 Occludin homology domain ADIP PF11559.8 EFX06281.1 - 0.44 10.6 0.0 0.44 10.6 0.0 3.1 4 0 0 4 4 2 0 Afadin- and alpha -actinin-Binding Macoilin PF09726.9 EFX06281.1 - 0.44 9.0 11.6 0.044 12.4 1.9 2.5 2 0 0 2 2 2 0 Macoilin family Fmp27_WPPW PF10359.9 EFX06281.1 - 0.49 9.2 5.8 3.1 6.5 2.2 2.4 2 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF4449 PF14613.6 EFX06281.1 - 0.96 9.5 5.9 0.33 11.1 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) IFT57 PF10498.9 EFX06281.1 - 1.1 8.2 7.2 0.54 9.2 1.4 2.4 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 AAA_13 PF13166.6 EFX06281.1 - 1.2 7.7 5.7 2.1 6.9 5.7 1.4 1 0 0 1 1 1 0 AAA domain FH2 PF02181.23 EFX06281.1 - 1.3 8.1 7.2 7.5 5.6 0.9 2.4 2 0 0 2 2 2 0 Formin Homology 2 Domain Prominin PF05478.11 EFX06281.1 - 1.3 6.9 3.2 2.1 6.2 3.2 1.2 1 0 0 1 1 1 0 Prominin GLTP PF08718.11 EFX06281.1 - 2 8.7 4.0 0.75 10.1 0.7 1.9 2 0 0 2 2 1 0 Glycolipid transfer protein (GLTP) ApoLp-III PF07464.11 EFX06281.1 - 2.4 8.2 7.5 0.69 10.0 1.2 2.9 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Bacillus_HBL PF05791.11 EFX06281.1 - 2.7 7.8 4.8 12 5.6 1.5 2.6 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) WXG100 PF06013.12 EFX06281.1 - 2.9 8.2 11.2 0.35 11.1 2.6 3.7 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Lectin_N PF03954.14 EFX06281.1 - 3.3 7.5 7.3 1.3 8.8 0.3 3.3 3 1 1 4 4 3 0 Hepatic lectin, N-terminal domain EzrA PF06160.12 EFX06281.1 - 3.4 5.7 9.0 1.6 6.8 1.7 2.2 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA KxDL PF10241.9 EFX06281.1 - 5 7.5 6.4 23 5.3 2.1 3.0 2 0 0 2 2 2 0 Uncharacterized conserved protein TMPIT PF07851.13 EFX06281.1 - 5.2 6.2 5.8 3 7.0 0.4 2.3 2 0 0 2 2 2 0 TMPIT-like protein ISG65-75 PF11727.8 EFX06281.1 - 5.2 6.2 9.8 11 5.2 3.3 2.7 1 1 1 2 2 2 0 Invariant surface glycoprotein DUF16 PF01519.16 EFX06281.1 - 6.6 7.3 9.1 4.7 7.7 3.2 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.12 EFX06281.1 - 7.4 6.6 21.0 0.53 10.4 4.8 3.6 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 EFX06281.1 - 9.2 7.0 6.6 9.8 6.9 1.4 2.9 2 0 0 2 2 2 0 Initiation control protein YabA DEAD PF00270.29 EFX06282.1 - 1.4e-32 112.9 0.0 5.7e-16 58.8 0.0 2.2 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX06282.1 - 9.7e-21 74.2 0.0 2e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFX06282.1 - 5.6e-19 68.1 0.0 1.2e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFX06282.1 - 0.018 15.1 0.0 0.044 13.8 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFX06282.1 - 0.21 10.8 0.0 0.36 10.0 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Collagen PF01391.18 EFX06283.1 - 4.3e-11 42.4 59.3 8.7e-08 31.8 26.9 2.6 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) Rad52_Rad22 PF04098.15 EFX06283.1 - 0.18 11.7 2.0 0.23 11.4 2.0 1.1 1 0 0 1 1 1 0 Rad52/22 family double-strand break repair protein ATG27 PF09451.10 EFX06284.1 - 1.6e-94 316.7 0.0 1.9e-94 316.5 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EFX06284.1 - 0.00021 21.4 0.0 0.0058 16.7 0.0 2.2 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat Aminotran_3 PF00202.21 EFX06286.1 - 6.7e-110 367.5 0.3 8.4e-110 367.2 0.3 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Sde2_N_Ubi PF13019.6 EFX06287.1 - 9e-63 211.0 0.1 1.3e-62 210.4 0.1 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Sugar_tr PF00083.24 EFX06288.1 - 2e-44 152.2 10.6 5e-29 101.5 0.1 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFX06288.1 - 1.3e-16 60.5 21.7 1.4e-08 34.1 1.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFX06288.1 - 4.8e-06 25.4 12.5 0.001 17.7 2.6 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein DLP_helical PF18709.1 EFX06290.1 - 0.13 11.4 0.0 12 4.9 0.0 2.5 2 0 0 2 2 2 0 Dynamin-like helical domain Baculo_PEP_C PF04513.12 EFX06290.1 - 0.15 12.1 13.5 0.19 11.8 2.9 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nuc_recep-AF1 PF11825.8 EFX06290.1 - 0.35 10.9 3.1 0.19 11.8 0.5 1.9 2 0 0 2 2 2 0 Nuclear/hormone receptor activator site AF-1 Bacillus_HBL PF05791.11 EFX06290.1 - 0.5 10.2 2.0 1.1 9.0 0.2 2.3 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF5367 PF17329.2 EFX06290.1 - 5.1 7.3 7.8 71 3.6 0.0 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5367) ADH_N PF08240.12 EFX06291.1 - 1.1e-28 99.3 0.4 1.9e-28 98.5 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX06291.1 - 5e-14 52.4 2.3 8.3e-14 51.7 2.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX06291.1 - 5.6e-11 43.6 0.2 9.9e-11 42.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase L51_S25_CI-B8 PF05047.16 EFX06292.1 - 4.7e-20 71.2 0.0 7.9e-20 70.5 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ADH_N PF08240.12 EFX06294.1 - 5.2e-22 77.8 2.2 5.2e-22 77.8 2.2 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 EFX06294.1 - 1.2e-10 41.1 1.9 1.2e-10 41.1 1.9 1.9 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 EFX06294.1 - 1.9e-05 24.7 0.2 0.0016 18.4 0.0 3.0 3 1 0 3 3 3 1 Zinc-binding dehydrogenase Zn_clus PF00172.18 EFX06296.1 - 0.0013 18.8 6.1 0.0032 17.5 6.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-met PF12874.7 EFX06296.1 - 0.0025 18.1 0.2 0.0074 16.7 0.2 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 EFX06296.1 - 0.024 14.6 6.9 0.024 14.6 6.9 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2 PF00096.26 EFX06296.1 - 0.034 14.6 3.0 0.11 12.9 3.0 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 EFX06296.1 - 0.047 14.2 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_jaz PF12171.8 EFX06296.1 - 0.054 13.8 0.2 0.13 12.6 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Rad50_zn_hook PF04423.14 EFX06296.1 - 0.076 12.9 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2H2_4 PF13894.6 EFX06296.1 - 2.4 9.2 4.2 9.3 7.4 4.2 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger Zn_ribbon_recom PF13408.6 EFX06296.1 - 6.4 7.4 8.8 20 5.8 8.8 1.9 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Hexapep PF00132.24 EFX06297.1 - 5.7e-06 25.8 2.6 0.0085 15.8 0.5 3.1 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFX06297.1 - 1.2e-05 25.7 0.2 1.2e-05 25.7 0.2 2.5 2 0 0 2 2 2 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 EFX06297.1 - 0.00023 20.9 0.0 0.00043 20.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 EFX06297.1 - 0.00065 18.8 1.3 0.0019 17.2 1.3 1.6 1 1 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 EFX06297.1 - 0.0021 16.3 0.1 0.0037 15.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EFX06297.1 - 0.052 13.3 3.9 8.8 6.2 1.3 3.2 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Gp_dh_C PF02800.20 EFX06298.1 - 1.6e-60 203.2 0.4 5.4e-47 159.3 0.1 2.2 1 1 1 2 2 2 2 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EFX06298.1 - 7e-39 132.3 0.1 1.6e-38 131.1 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Peptidase_M20 PF01546.28 EFX06299.1 - 1.2e-29 103.5 0.0 4e-29 101.8 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFX06299.1 - 9.1e-12 44.9 0.2 1.2e-10 41.2 0.2 2.2 1 1 0 1 1 1 1 Peptidase dimerisation domain KxDL PF10241.9 EFX06300.1 - 8.2e-29 99.7 3.5 1.1e-28 99.3 3.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein Phage_TAC_11 PF11836.8 EFX06300.1 - 0.02 15.0 0.1 0.03 14.4 0.1 1.2 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 DUF4890 PF16231.5 EFX06300.1 - 0.11 13.1 4.9 0.16 12.5 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4890) Filament_head PF04732.14 EFX06300.1 - 0.32 11.9 6.8 0.77 10.7 6.8 1.6 1 0 0 1 1 1 0 Intermediate filament head (DNA binding) region SUIM_assoc PF16619.5 EFX06302.1 - 1.2 9.3 8.8 0.2 11.7 4.1 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RasGEF PF00617.19 EFX06303.1 - 5.9e-50 169.9 0.0 2.2e-49 168.1 0.0 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFX06303.1 - 6.5e-15 55.3 0.0 3.8e-14 52.8 0.0 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_9 PF14604.6 EFX06303.1 - 1.1e-06 28.4 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFX06303.1 - 3e-05 23.5 0.0 7.5e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain Gelsolin PF00626.22 EFX06304.1 - 1.3e-28 98.7 0.0 4.1e-12 45.8 0.0 3.4 3 0 0 3 3 3 3 Gelsolin repeat ADH_zinc_N PF00107.26 EFX06304.1 - 4.1e-11 43.0 0.4 9.8e-11 41.8 0.4 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFX06304.1 - 8.4e-10 38.5 0.0 2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TRF PF08558.10 EFX06305.1 - 4.4e-29 101.8 0.6 1.3e-27 97.0 0.6 2.2 1 1 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EFX06305.1 - 3.8e-05 23.8 0.0 8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX06305.1 - 0.16 12.2 0.0 0.49 10.7 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain HNH_2 PF13391.6 EFX06306.1 - 5.4e-08 32.9 0.1 1.1e-07 31.8 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease PH_10 PF15411.6 EFX06307.1 - 1.8e-41 141.3 0.1 4.1e-41 140.1 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 EFX06307.1 - 1.3e-32 111.9 0.0 2.6e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 EFX06307.1 - 3.3e-29 102.4 0.4 5.9e-29 101.6 0.4 1.4 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 EFX06307.1 - 1.6e-08 34.3 0.1 3.7e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 PB1 domain BRO1 PF03097.18 EFX06308.1 - 3e-119 398.3 0.1 4.3e-119 397.8 0.1 1.2 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EFX06308.1 - 4.4e-78 262.6 0.9 4.4e-78 262.6 0.9 2.5 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF4734 PF15881.5 EFX06308.1 - 0.36 11.0 3.9 0.3 11.3 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) Steroid_dh PF02544.16 EFX06309.1 - 4.9e-19 68.8 0.1 1.8e-11 44.3 0.1 2.3 2 0 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EFX06309.1 - 0.00012 21.7 2.9 0.00012 21.7 0.9 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) Zn_clus PF00172.18 EFX06310.1 - 2.9e-09 36.9 6.9 4.6e-09 36.3 6.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EFX06310.1 - 2.1e-07 30.1 0.5 0.011 14.5 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain SNARE PF05739.19 EFX06312.1 - 8.6e-17 60.9 1.6 1.7e-16 59.9 1.6 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 EFX06312.1 - 3.4e-10 40.2 11.2 8.2e-06 26.1 1.3 3.6 2 2 1 3 3 3 2 Syntaxin-like protein Syntaxin PF00804.25 EFX06312.1 - 2.2e-09 37.3 7.3 3.6e-09 36.6 7.3 1.3 1 0 0 1 1 1 1 Syntaxin Prominin PF05478.11 EFX06312.1 - 0.0013 16.8 2.3 0.002 16.2 2.3 1.4 1 1 0 1 1 1 1 Prominin Synaptobrevin PF00957.21 EFX06312.1 - 0.031 14.1 0.4 0.083 12.7 0.4 1.7 1 0 0 1 1 1 0 Synaptobrevin K_channel_TID PF07941.11 EFX06312.1 - 1.6 9.3 11.8 0.22 12.0 3.6 2.9 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain DUF16 PF01519.16 EFX06312.1 - 2.6 8.6 8.2 6.5 7.3 6.0 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 ABC_tran PF00005.27 EFX06313.1 - 3.3e-28 98.9 0.0 1.6e-18 67.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFX06313.1 - 6.1e-13 49.1 19.4 2.9e-11 43.5 8.3 3.6 2 2 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EFX06313.1 - 5.9e-09 36.1 0.0 0.00054 19.9 0.0 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX06313.1 - 3.8e-06 26.5 0.1 0.22 10.9 0.0 3.0 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EFX06313.1 - 0.0033 16.8 0.0 0.015 14.6 0.0 2.0 2 0 0 2 2 2 1 FtsK/SpoIIIE family SbcCD_C PF13558.6 EFX06313.1 - 0.01 16.0 3.1 0.97 9.7 0.0 3.2 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EFX06313.1 - 0.014 15.8 0.1 0.035 14.5 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFX06313.1 - 0.015 15.5 0.2 0.086 13.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 EFX06313.1 - 0.066 13.0 0.0 4.7 6.9 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF87 PF01935.17 EFX06313.1 - 0.071 13.2 0.2 0.13 12.4 0.2 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 EFX06313.1 - 0.078 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFX06313.1 - 0.1 12.5 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase MobB PF03205.14 EFX06313.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.17 EFX06313.1 - 0.15 11.8 0.4 4.1 7.1 0.1 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF1240 PF06836.12 EFX06313.1 - 1.8 9.2 4.8 0.62 10.6 1.2 2.0 2 0 0 2 2 1 0 Protein of unknown function (DUF1240) Fur_reg_FbpB PF13040.6 EFX06314.1 - 0.37 10.4 2.8 0.41 10.2 0.1 2.2 2 0 0 2 2 2 0 Fur-regulated basic protein B DUF423 PF04241.15 EFX06315.1 - 8.8e-25 86.7 1.7 1.6e-24 85.9 1.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Cyt-b5 PF00173.28 EFX06317.1 - 5.1e-12 45.8 0.1 7.5e-12 45.2 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Subtilosin_A PF11420.8 EFX06320.1 - 0.11 12.5 0.4 0.25 11.3 0.4 1.6 1 0 0 1 1 1 0 Bacteriocin subtilosin A Abhydrolase_3 PF07859.13 EFX06321.1 - 3.6e-58 196.9 0.0 1.7e-56 191.4 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFX06321.1 - 2.1e-09 36.8 0.0 5.2e-09 35.5 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EFX06321.1 - 0.0036 16.8 0.0 0.6 9.6 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EFX06321.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF1697 PF08002.11 EFX06322.1 - 0.045 14.2 0.7 0.086 13.3 0.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1697) zf-C4H2 PF10146.9 EFX06322.1 - 0.062 13.6 3.3 0.081 13.2 3.3 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein SlyX PF04102.12 EFX06322.1 - 0.087 13.5 0.5 0.087 13.5 0.5 2.3 1 1 1 2 2 2 0 SlyX DUF4407 PF14362.6 EFX06322.1 - 0.16 11.3 8.8 0.18 11.1 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BAF1_ABF1 PF04684.13 EFX06322.1 - 0.21 10.6 5.3 0.24 10.4 5.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AAA_13 PF13166.6 EFX06322.1 - 0.23 10.1 3.4 0.28 9.8 3.4 1.0 1 0 0 1 1 1 0 AAA domain Fez1 PF06818.15 EFX06322.1 - 0.24 11.8 5.1 0.32 11.4 5.1 1.1 1 0 0 1 1 1 0 Fez1 XhlA PF10779.9 EFX06322.1 - 0.26 11.5 0.2 0.26 11.5 0.2 1.8 2 0 0 2 2 2 0 Haemolysin XhlA FliD_N PF02465.18 EFX06322.1 - 0.3 11.8 5.5 0.54 11.0 5.5 1.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus V_ATPase_I PF01496.19 EFX06322.1 - 0.69 7.8 2.2 0.83 7.5 2.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SKA1 PF07160.12 EFX06322.1 - 1.1 9.0 6.3 1.9 8.3 6.3 1.4 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF16 PF01519.16 EFX06322.1 - 2 9.0 6.0 0.63 10.5 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Methyltransf_2 PF00891.18 EFX06323.1 - 5.3e-22 78.1 0.0 8.5e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain HET PF06985.11 EFX06323.1 - 2.8e-16 60.2 0.1 1.2e-15 58.2 0.0 2.0 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) NUDIX_4 PF14815.6 EFX06324.1 - 2.1e-18 66.3 0.0 5e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 EFX06324.1 - 4.6e-17 62.4 0.0 1.3e-16 60.9 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EFX06324.1 - 1.3e-06 28.0 0.1 4.9e-06 26.1 0.1 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif PBP1_TM PF14812.6 EFX06324.1 - 0.16 12.3 6.3 0.69 10.3 6.3 2.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 EFX06324.1 - 1.3 7.2 3.2 2.1 6.5 3.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Aconitase PF00330.20 EFX06325.1 - 2.1e-107 360.0 1.1 1.7e-106 357.0 1.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFX06325.1 - 6.8e-28 97.6 0.0 1.2e-27 96.8 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain JmjC PF02373.22 EFX06326.1 - 2.2e-37 128.0 0.4 4.3e-37 127.0 0.4 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 EFX06326.1 - 1.3e-18 67.2 4.6 2.3e-18 66.3 4.6 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EFX06326.1 - 1.7e-15 57.0 3.7 3.7e-15 56.0 3.7 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.17 EFX06326.1 - 2.3e-11 43.5 0.7 5e-11 42.4 0.7 1.6 1 0 0 1 1 1 1 jmjN domain HLH PF00010.26 EFX06327.1 - 1.2e-05 25.1 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain UDPGT PF00201.18 EFX06328.1 - 2.8e-11 42.9 0.0 3.8e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase MFS_1 PF07690.16 EFX06329.1 - 2.3e-46 158.4 29.9 5.3e-40 137.4 13.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX06329.1 - 1.1e-09 37.7 8.4 1.1e-09 37.7 8.4 3.0 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EFX06329.1 - 1.2e-08 33.9 1.8 1.8e-08 33.3 1.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EFX06329.1 - 0.0054 15.1 0.1 0.013 13.8 0.1 1.6 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Septin PF00735.18 EFX06330.1 - 1.5e-110 368.9 0.4 1.8e-110 368.7 0.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EFX06330.1 - 8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFX06330.1 - 1.2e-05 24.7 0.0 2.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EFX06330.1 - 3e-05 24.0 0.2 0.00037 20.4 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFX06330.1 - 0.00021 20.9 0.6 0.009 15.6 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFX06330.1 - 0.00094 19.3 0.3 1.3 9.1 0.2 2.6 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 EFX06330.1 - 0.0033 17.8 0.0 0.0074 16.7 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EFX06330.1 - 0.0048 16.4 0.0 0.028 13.9 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region NB-ARC PF00931.22 EFX06330.1 - 0.0059 15.8 0.1 0.011 15.0 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EFX06330.1 - 0.0062 16.8 0.1 0.013 15.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFX06330.1 - 0.017 15.7 0.6 0.025 15.1 0.4 1.7 1 1 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.12 EFX06330.1 - 0.026 13.9 0.1 0.21 10.9 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Roc PF08477.13 EFX06330.1 - 0.066 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EFX06330.1 - 0.072 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family G-alpha PF00503.20 EFX06330.1 - 0.074 12.2 1.1 0.25 10.5 0.7 2.1 1 1 1 2 2 2 0 G-protein alpha subunit T2SSE PF00437.20 EFX06330.1 - 0.074 12.1 0.1 0.23 10.5 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Ras PF00071.22 EFX06330.1 - 0.08 12.5 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 Ras family Microtub_bd PF16796.5 EFX06330.1 - 0.092 12.7 0.1 0.57 10.1 0.0 2.1 2 0 0 2 2 2 0 Microtubule binding AAA_29 PF13555.6 EFX06330.1 - 0.19 11.5 0.0 0.4 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 EFX06331.1 - 5e-18 65.2 0.0 8.1e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX06331.1 - 9.2e-06 25.9 0.0 4.4e-05 23.7 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFX06331.1 - 0.098 12.7 0.0 0.22 11.6 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Aim19 PF10315.9 EFX06332.1 - 2.3e-07 31.1 0.6 1.5e-06 28.5 0.2 2.0 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 19 DUF5429 PF17494.2 EFX06332.1 - 2.1 8.4 8.1 1.2 9.3 0.5 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5429) RabGAP-TBC PF00566.18 EFX06333.1 - 1.7e-44 152.0 0.0 4.1e-44 150.8 0.0 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain USP8_interact PF08941.10 EFX06333.1 - 1.8 8.3 7.3 0.71 9.7 3.7 2.1 2 0 0 2 2 2 0 USP8 interacting HMA PF00403.26 EFX06334.1 - 2.2e-16 60.0 0.8 3.3e-16 59.5 0.3 1.5 2 0 0 2 2 2 1 Heavy-metal-associated domain CTU2 PF10288.9 EFX06334.1 - 0.087 13.1 0.5 0.21 11.8 0.1 1.7 1 1 1 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 IU_nuc_hydro PF01156.19 EFX06335.1 - 1.6e-33 116.6 0.0 1.8e-33 116.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF1593 PF07632.11 EFX06335.1 - 0.0054 16.2 0.0 0.0075 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Epimerase PF01370.21 EFX06336.1 - 2.4e-16 59.9 0.3 8.3e-16 58.2 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX06336.1 - 2.5e-11 43.1 0.0 1.9e-10 40.3 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFX06336.1 - 2.8e-11 43.1 0.2 3.3e-10 39.6 0.2 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EFX06336.1 - 2.3e-08 34.1 0.8 3.7e-08 33.5 0.8 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFX06336.1 - 9.7e-08 31.8 0.0 1.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFX06336.1 - 6.5e-05 22.2 0.0 9.7e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EFX06336.1 - 0.0014 18.1 0.0 0.004 16.6 0.0 1.8 2 1 0 2 2 2 1 short chain dehydrogenase F420_oxidored PF03807.17 EFX06336.1 - 0.0026 18.3 0.0 0.0072 16.9 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 EFX06336.1 - 0.066 12.7 0.2 0.1 12.1 0.2 1.5 1 1 0 1 1 1 0 NmrA-like family GXWXG PF14231.6 EFX06336.1 - 0.14 12.3 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 GXWXG protein HECT PF00632.25 EFX06337.1 - 1.9e-77 260.7 0.0 2.7e-77 260.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SprA-related PF12118.8 EFX06338.1 - 1.1 8.4 14.0 1.2 8.2 14.0 1.0 1 0 0 1 1 1 0 SprA-related family ADH_N PF08240.12 EFX06339.1 - 2.3e-30 104.7 0.5 4e-30 103.9 0.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFX06339.1 - 8.9e-22 77.5 0.1 1.4e-21 76.8 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFX06339.1 - 0.0002 22.4 0.0 0.00036 21.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SNF2_N PF00176.23 EFX06340.1 - 3.7e-09 35.8 0.0 0.0002 20.2 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFX06340.1 - 7.7e-05 23.0 0.0 0.00016 22.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain BING4CT PF08149.11 EFX06341.1 - 2.4e-39 133.0 0.0 1.1e-35 121.2 0.0 3.2 3 0 0 3 3 3 2 BING4CT (NUC141) domain WD40 PF00400.32 EFX06341.1 - 4.1e-07 30.6 0.7 0.041 14.8 0.0 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EFX06341.1 - 0.001 18.2 0.1 0.0022 17.1 0.0 1.5 2 0 0 2 2 2 1 Coatomer WD associated region DOCK_N PF16172.5 EFX06343.1 - 2.5e-120 401.9 0.0 3.7e-120 401.3 0.0 1.3 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EFX06343.1 - 2.3e-34 118.9 0.0 3.8e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 EFX06343.1 - 8.2e-29 100.6 3.4 1.2e-27 96.7 3.4 2.6 1 1 0 1 1 1 1 Dock homology region 2 SH3_1 PF00018.28 EFX06343.1 - 0.00026 20.5 0.0 0.00055 19.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFX06343.1 - 0.045 13.6 0.0 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 Variant SH3 domain SH3_2 PF07653.17 EFX06343.1 - 0.13 11.9 0.0 0.35 10.6 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain FAM91_C PF14648.6 EFX06344.1 - 0.0025 16.8 2.7 0.0046 15.8 2.7 1.4 1 0 0 1 1 1 1 FAM91 C-terminus APH PF01636.23 EFX06344.1 - 0.0093 15.9 0.2 0.0093 15.9 0.2 3.8 2 2 1 3 3 3 1 Phosphotransferase enzyme family YABBY PF04690.13 EFX06344.1 - 1.3 9.5 8.3 6.7 7.2 5.9 2.7 2 0 0 2 2 2 0 YABBY protein NPR3 PF03666.13 EFX06344.1 - 5.9 5.6 14.0 0.33 9.7 6.9 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2052 PF09747.9 EFX06344.1 - 7.1 6.7 35.1 0.051 13.7 1.9 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) His_Phos_1 PF00300.22 EFX06346.1 - 1.3e-22 80.4 3.5 3.1e-21 76.0 3.5 2.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pyridoxal_deC PF00282.19 EFX06347.1 - 6.4e-75 252.2 0.0 9.6e-75 251.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain OKR_DC_1 PF01276.20 EFX06347.1 - 0.084 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain ATP-synt_F6 PF05511.11 EFX06347.1 - 0.085 13.3 0.2 0.26 11.7 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 PPI_Ypi1 PF07491.11 EFX06349.1 - 3.7e-23 81.1 5.0 1.5e-22 79.1 5.0 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor KH_1 PF00013.29 EFX06349.1 - 4.6e-09 36.0 0.0 1.9e-07 30.8 0.0 2.9 3 0 0 3 3 3 1 KH domain ATLF PF07737.11 EFX06349.1 - 0.034 13.4 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain DLIC PF05783.11 EFX06349.1 - 0.35 9.7 2.5 0.83 8.4 2.5 1.6 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AtuA PF07287.11 EFX06350.1 - 8.2e-124 412.9 0.0 1e-123 412.6 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Dynamin_N PF00350.23 EFX06352.1 - 8e-33 113.9 0.2 1.8e-32 112.7 0.2 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EFX06352.1 - 7.5e-23 81.2 0.1 3.5e-19 69.1 0.0 3.0 4 0 0 4 4 4 2 Dynamin central region MMR_HSR1 PF01926.23 EFX06352.1 - 3.1e-05 24.0 0.3 0.0014 18.7 0.3 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EFX06352.1 - 0.0003 20.9 0.2 0.0039 17.3 0.0 3.0 3 0 0 3 3 3 1 Dynamin GTPase effector domain HBM PF16591.5 EFX06352.1 - 0.01 15.3 3.2 0.034 13.6 1.9 2.3 2 0 0 2 2 2 1 Helical bimodular sensor domain Roc PF08477.13 EFX06352.1 - 0.037 14.2 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EFX06352.1 - 0.044 13.3 0.1 11 5.6 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_21 PF13304.6 EFX06352.1 - 0.092 12.5 0.1 1.9 8.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system RUN PF02759.19 EFX06352.1 - 0.1 12.6 0.3 1.4 8.8 0.1 2.7 2 1 1 3 3 3 0 RUN domain DEAD_2 PF06733.15 EFX06354.1 - 1.2e-57 194.4 0.5 1.2e-57 194.4 0.5 1.9 2 0 0 2 2 2 1 DEAD_2 HBB PF06777.11 EFX06354.1 - 2e-49 167.9 2.3 5.9e-44 150.0 0.8 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EFX06354.1 - 2.8e-42 144.8 0.2 1.1e-41 142.9 0.0 2.1 3 0 0 3 3 3 1 Helicase C-terminal domain ResIII PF04851.15 EFX06354.1 - 0.00029 20.9 0.1 0.0084 16.1 0.1 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFX06354.1 - 0.0044 16.8 0.0 0.96 9.2 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase SNF2_N PF00176.23 EFX06354.1 - 0.0048 15.7 0.0 0.083 11.6 0.0 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain PhoH PF02562.16 EFX06354.1 - 0.13 11.7 0.1 6.5 6.2 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 EFX06354.1 - 0.15 12.3 1.7 11 6.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain Smg4_UPF3 PF03467.15 EFX06355.1 - 7.4e-47 159.6 0.0 1.9e-46 158.2 0.0 1.8 1 0 0 1 1 1 1 Smg-4/UPF3 family RRM_1 PF00076.22 EFX06355.1 - 8.5e-07 28.7 0.3 2.1e-05 24.2 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIGA PF08288.12 EFX06356.1 - 1.3e-47 160.3 3.2 1.7e-47 159.9 1.0 2.2 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EFX06356.1 - 4.3e-29 101.7 1.5 6.4e-29 101.1 0.3 1.9 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EFX06356.1 - 7.7e-28 97.2 0.0 1.4e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFX06356.1 - 9e-24 84.4 0.1 2.3e-23 83.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFX06356.1 - 4.4e-14 53.2 0.0 2.4e-13 50.9 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EFX06356.1 - 9.2e-07 29.0 0.1 1.9e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EFX06356.1 - 8.6e-05 22.9 0.1 0.00033 21.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Ank_2 PF12796.7 EFX06358.1 - 3.2e-07 30.8 0.4 0.0016 19.0 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFX06358.1 - 0.00011 22.4 4.0 0.0094 16.3 0.4 3.9 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFX06358.1 - 0.00067 20.2 0.5 0.17 12.5 0.0 4.4 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06358.1 - 0.0086 16.5 1.5 0.11 13.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFX06358.1 - 0.047 14.1 3.2 0.4 11.2 0.2 3.3 3 0 0 3 3 3 0 Ankyrin repeat Macoilin PF09726.9 EFX06358.1 - 0.17 10.4 6.1 0.26 9.8 6.1 1.2 1 0 0 1 1 1 0 Macoilin family EF-hand_4 PF12763.7 EFX06359.1 - 1.5e-29 102.0 0.0 1.3e-11 44.3 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 EFX06359.1 - 1.5e-06 28.0 0.0 3.4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 EFX06359.1 - 3.4e-06 27.4 0.0 0.0013 19.1 0.0 3.8 4 0 0 4 4 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EFX06359.1 - 0.00058 19.6 0.0 0.53 10.4 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain DUF812 PF05667.11 EFX06359.1 - 0.0011 17.9 15.8 0.0011 17.9 15.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.12 EFX06359.1 - 0.0027 17.7 24.8 0.0027 17.7 24.8 2.9 2 1 1 3 3 2 2 TPR/MLP1/MLP2-like protein BicD PF09730.9 EFX06359.1 - 0.0046 15.4 20.6 0.0073 14.8 20.6 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D EF-hand_1 PF00036.32 EFX06359.1 - 0.01 15.3 0.0 7.3 6.4 0.0 3.7 3 0 0 3 3 3 0 EF hand PRKG1_interact PF15898.5 EFX06359.1 - 0.016 16.1 10.0 0.016 16.1 10.0 3.6 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain GAS PF13851.6 EFX06359.1 - 0.017 14.5 33.9 0.044 13.1 13.8 2.7 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EFX06359.1 - 0.044 14.2 17.0 5.4 7.5 0.1 4.7 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 EFX06359.1 - 0.12 11.3 33.2 1.3 7.8 21.2 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Lebercilin PF15619.6 EFX06359.1 - 0.13 11.9 33.5 0.19 11.4 33.5 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF4201 PF13870.6 EFX06359.1 - 0.17 11.6 26.6 1.6 8.4 5.7 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) APG6_N PF17675.1 EFX06359.1 - 0.35 11.4 36.8 0.39 11.2 17.1 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region CortBP2 PF09727.9 EFX06359.1 - 0.38 10.6 26.4 1.2 9.1 11.2 3.2 3 0 0 3 3 3 0 Cortactin-binding protein-2 CENP-F_leu_zip PF10473.9 EFX06359.1 - 0.82 9.7 34.0 0.13 12.2 11.0 3.6 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 EFX06359.1 - 1.3 6.4 28.7 2.1 5.8 28.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 EFX06359.1 - 1.5 8.9 18.7 0.14 12.2 7.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fmp27_WPPW PF10359.9 EFX06359.1 - 1.7 7.4 21.6 0.44 9.3 9.1 2.2 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF724 PF05266.14 EFX06359.1 - 2.8 7.7 25.0 0.14 12.0 8.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF724) FliJ PF02050.16 EFX06359.1 - 2.8 8.2 34.0 10 6.4 17.5 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein TMF_TATA_bd PF12325.8 EFX06359.1 - 3.2 8.0 28.9 12 6.1 7.5 3.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Golgin_A5 PF09787.9 EFX06359.1 - 3.2 7.1 31.6 16 4.9 31.7 1.7 1 1 0 1 1 1 0 Golgin subfamily A member 5 Seryl_tRNA_N PF02403.22 EFX06359.1 - 3.4 7.9 26.3 33 4.8 3.8 3.6 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 EFX06359.1 - 3.6 7.8 44.8 0.068 13.4 21.4 3.4 2 1 2 4 4 3 0 Autophagy protein 16 (ATG16) Leu_zip PF15294.6 EFX06359.1 - 3.6 7.0 25.5 1.5 8.3 22.0 1.8 1 1 1 2 2 2 0 Leucine zipper PI3K_P85_iSH2 PF16454.5 EFX06359.1 - 4 7.0 26.6 0.8 9.3 2.2 3.2 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Occludin_ELL PF07303.13 EFX06359.1 - 5.5 7.8 16.6 7.5 7.3 3.8 4.1 2 1 2 4 4 4 0 Occludin homology domain NYD-SP28_assoc PF14775.6 EFX06359.1 - 6.7 6.9 7.3 1.5 8.9 2.2 2.5 2 1 0 2 2 2 0 Sperm tail C-terminal domain DUF4618 PF15397.6 EFX06359.1 - 7 6.0 23.7 52 3.1 1.1 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Ribosomal_S15 PF00312.22 EFX06359.1 - 7.8 6.8 7.0 8.7 6.6 0.5 2.6 2 1 0 2 2 2 0 Ribosomal protein S15 Filament PF00038.21 EFX06359.1 - 8 5.9 28.2 1.5e+02 1.7 27.9 2.3 1 1 0 1 1 1 0 Intermediate filament protein AIP3 PF03915.13 EFX06359.1 - 8.7 5.3 21.5 15 4.6 21.5 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Laminin_II PF06009.12 EFX06359.1 - 8.9 6.3 23.0 6.8 6.7 6.4 2.7 1 1 1 2 2 2 0 Laminin Domain II DASH_Dad1 PF08649.10 EFX06360.1 - 5.1e-26 90.6 1.4 6.5e-26 90.3 1.4 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 Epimerase PF01370.21 EFX06361.1 - 1.4e-17 64.0 0.0 2.1e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFX06361.1 - 4.2e-08 32.5 0.0 9.5e-08 31.4 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFX06361.1 - 9.5e-08 32.1 0.3 1.5e-07 31.5 0.3 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFX06361.1 - 6.2e-07 29.2 0.6 1.1e-06 28.5 0.6 1.4 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EFX06361.1 - 9.3e-06 25.3 0.0 2.7e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFX06361.1 - 0.0002 20.6 0.2 0.00022 20.5 0.2 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EFX06361.1 - 0.00097 18.6 0.1 0.0023 17.4 0.1 1.6 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EFX06361.1 - 0.0012 18.1 0.0 0.0028 16.8 0.0 1.6 2 0 0 2 2 2 1 Male sterility protein AlaDh_PNT_C PF01262.21 EFX06361.1 - 0.041 13.2 3.0 0.12 11.7 0.1 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DFP PF04127.15 EFX06361.1 - 0.056 13.3 0.1 0.096 12.5 0.1 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein F420_oxidored PF03807.17 EFX06361.1 - 0.057 14.0 0.2 0.14 12.8 0.1 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent KR PF08659.10 EFX06361.1 - 0.074 12.9 1.5 0.33 10.8 1.5 2.0 1 1 0 1 1 1 0 KR domain Sacchrp_dh_NADP PF03435.18 EFX06361.1 - 0.086 13.1 0.2 0.15 12.3 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Cupredoxin_1 PF13473.6 EFX06362.1 - 0.0092 16.1 0.1 0.025 14.7 0.1 1.7 2 0 0 2 2 2 1 Cupredoxin-like domain Cu_bind_like PF02298.17 EFX06362.1 - 0.023 14.7 0.2 0.055 13.5 0.2 1.7 1 1 0 1 1 1 0 Plastocyanin-like domain SR-25 PF10500.9 EFX06362.1 - 2.2 7.9 16.6 3.2 7.3 16.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MGC-24 PF05283.11 EFX06362.1 - 6.7 7.2 13.7 1.4 9.3 9.2 1.9 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Herpes_capsid PF06112.11 EFX06362.1 - 8.4 6.4 21.5 14 5.7 21.5 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein NAD_binding_10 PF13460.6 EFX06364.1 - 2.8e-12 46.9 0.0 6.4e-12 45.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EFX06364.1 - 1.8e-05 24.4 0.0 8e-05 22.3 0.0 1.8 1 1 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EFX06364.1 - 0.00036 20.0 0.0 0.027 13.9 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 EFX06364.1 - 0.00043 20.8 0.1 0.0015 19.1 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 EFX06364.1 - 0.0014 18.1 0.0 1.1 8.7 0.0 2.4 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 EFX06364.1 - 0.0043 17.5 0.4 0.034 14.6 0.1 2.4 2 1 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFX06364.1 - 0.012 15.6 0.0 0.096 12.8 0.0 2.3 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EFX06364.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EFX06364.1 - 0.026 14.8 0.2 0.081 13.2 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EFX06364.1 - 0.035 14.3 0.2 1.9 8.8 0.1 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Glyco_transf_4 PF13439.6 EFX06364.1 - 0.15 12.1 0.1 0.82 9.6 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Methyltransf_23 PF13489.6 EFX06365.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Kp4 PF09044.10 EFX06369.1 - 6.4e-31 107.0 5.9 9.1e-31 106.5 5.9 1.2 1 0 0 1 1 1 1 Kp4 Aldo_ket_red PF00248.21 EFX06370.1 - 7.8e-44 150.0 0.0 1.3e-43 149.2 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family E1-E2_ATPase PF00122.20 EFX06371.1 - 0.23 10.9 3.7 0.15 11.6 1.8 1.6 1 1 1 2 2 2 0 E1-E2 ATPase IMS PF00817.20 EFX06372.1 - 2e-29 102.5 0.0 4.3e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C2 PF00168.30 EFX06372.1 - 2.2e-24 85.7 0.0 9.4e-14 51.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain IMS_C PF11799.8 EFX06372.1 - 7.2e-05 23.5 0.0 0.00022 21.9 0.0 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain MAPEG PF01124.18 EFX06373.1 - 2.5e-16 59.7 3.1 3.6e-16 59.3 3.1 1.3 1 0 0 1 1 1 1 MAPEG family Rxt3 PF08642.10 EFX06374.1 - 2.5e-14 54.1 2.2 3.1e-14 53.8 0.0 2.3 2 1 0 2 2 2 1 Histone deacetylation protein Rxt3 Peroxidase_2 PF01328.17 EFX06375.1 - 3.5e-40 138.5 0.0 4.7e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 NB-ARC PF00931.22 EFX06376.1 - 1e-14 54.3 0.0 2e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 EFX06376.1 - 3.1e-10 40.2 17.0 2.8e-06 27.5 3.7 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat AAA_16 PF13191.6 EFX06376.1 - 4.2e-06 27.3 0.6 5.9e-05 23.5 0.0 3.0 2 2 0 2 2 2 1 AAA ATPase domain TPR_10 PF13374.6 EFX06376.1 - 5.7e-05 22.8 12.7 0.73 9.8 0.1 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat AAA_22 PF13401.6 EFX06376.1 - 0.00041 20.6 0.0 0.0045 17.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain zf-C2H2_2 PF12756.7 EFX06376.1 - 0.00091 19.5 7.1 0.0029 17.9 7.1 1.9 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF629 PF04780.12 EFX06376.1 - 0.0025 16.4 4.3 0.0046 15.5 4.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF629) ATPase_2 PF01637.18 EFX06376.1 - 0.0037 17.2 0.0 0.0076 16.2 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea HeLo PF14479.6 EFX06376.1 - 0.03 14.2 0.2 0.11 12.3 0.2 2.0 1 0 0 1 1 1 0 Prion-inhibition and propagation TPR_2 PF07719.17 EFX06376.1 - 0.036 14.2 0.3 0.036 14.2 0.3 3.9 5 0 0 5 5 3 0 Tetratricopeptide repeat AAA_25 PF13481.6 EFX06376.1 - 0.067 12.8 0.0 0.3 10.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFX06376.1 - 0.082 12.8 0.0 0.25 11.2 0.0 1.9 1 0 0 1 1 1 0 NACHT domain TPR_7 PF13176.6 EFX06376.1 - 0.18 11.9 4.7 2.8 8.2 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFX06376.1 - 0.23 12.4 16.5 0.74 10.8 0.2 5.7 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFX06376.1 - 0.4 10.6 4.2 1.3 8.9 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFX06376.1 - 0.61 10.4 5.0 71 4.0 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C2H2_9 PF16293.5 EFX06376.1 - 0.91 9.4 4.4 4.7 7.1 0.5 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.6 EFX06376.1 - 4.2 8.0 10.1 0.2 12.2 0.6 3.0 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.12 EFX06376.1 - 4.4 7.7 12.4 4.9 7.5 2.1 3.2 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-4CXXC_R1 PF10497.9 EFX06376.1 - 5.5 7.3 8.6 1.8 8.8 5.4 1.9 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 adh_short PF00106.25 EFX06377.1 - 2.6e-06 27.1 0.0 6.5e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFX06377.1 - 3.9e-06 26.6 0.0 6.2e-06 25.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Arm PF00514.23 EFX06377.1 - 0.17 12.0 0.3 3.3 7.9 0.0 2.5 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat RdRP PF05183.12 EFX06378.1 - 2.6e-181 604.3 0.0 3.3e-181 603.9 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF3533 PF12051.8 EFX06379.1 - 4.9e-49 167.3 0.2 6.6e-49 166.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Mur_ligase_M PF08245.12 EFX06379.1 - 1.1e-05 25.6 0.0 3.3e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Mur ligase middle domain Phage_head_chap PF11113.8 EFX06379.1 - 0.16 12.1 0.2 0.84 9.8 0.0 2.1 2 0 0 2 2 2 0 Head assembly gene product FAD_binding_6 PF00970.24 EFX06380.1 - 7.8e-32 109.6 0.0 1.2e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFX06380.1 - 1.6e-30 106.0 0.0 2.5e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFX06380.1 - 3.8e-06 27.1 0.0 0.00013 22.2 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EFX06380.1 - 0.0023 18.1 0.0 0.038 14.2 0.0 2.1 1 1 1 2 2 2 1 Siderophore-interacting FAD-binding domain AAA_22 PF13401.6 EFX06381.1 - 0.012 15.8 0.0 0.033 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX06381.1 - 0.039 14.3 0.3 0.16 12.3 0.3 2.2 1 1 0 1 1 1 0 AAA ATPase domain LSM14 PF12701.7 EFX06382.1 - 1.8e-30 104.9 0.1 2.9e-30 104.2 0.1 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EFX06382.1 - 8.2e-19 68.4 3.2 8.2e-19 68.4 3.2 2.2 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.6 EFX06382.1 - 1.9e-06 27.9 0.0 3.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain ORC6 PF05460.13 EFX06383.1 - 8.1e-31 107.6 8.0 6e-30 104.7 3.3 2.3 2 1 0 2 2 2 2 Origin recognition complex subunit 6 (ORC6) AA_permease_2 PF13520.6 EFX06384.1 - 1.4e-39 136.1 47.2 2.6e-30 105.6 16.5 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EFX06384.1 - 8e-18 64.3 45.8 2.7e-16 59.2 45.8 2.0 1 1 0 1 1 1 1 Amino acid permease GAPT PF11770.8 EFX06384.1 - 0.092 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Abhydrolase_3 PF07859.13 EFX06385.1 - 1.5e-35 122.9 0.0 5.9e-25 88.4 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Fzo_mitofusin PF04799.13 EFX06386.1 - 0.11 12.0 0.3 0.16 11.5 0.3 1.1 1 0 0 1 1 1 0 fzo-like conserved region DAO PF01266.24 EFX06387.1 - 4.4e-38 131.8 10.4 5e-38 131.6 10.4 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX06387.1 - 4.9e-06 26.0 1.2 0.0062 15.8 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFX06387.1 - 0.00016 21.7 4.3 0.13 12.3 0.7 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFX06387.1 - 0.00031 20.9 0.3 0.00031 20.9 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFX06387.1 - 0.00087 18.5 6.5 0.081 12.0 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX06387.1 - 0.0028 16.8 2.6 0.16 11.0 0.2 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein ApbA PF02558.16 EFX06387.1 - 0.0047 16.6 3.7 0.0083 15.8 3.7 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EFX06387.1 - 0.011 15.6 1.9 0.019 14.8 1.9 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFX06387.1 - 0.044 14.4 1.7 0.1 13.2 1.7 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EFX06387.1 - 0.067 13.6 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFX06387.1 - 0.074 13.1 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 EFX06387.1 - 0.12 11.5 0.1 0.24 10.5 0.0 1.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) GMC_oxred_N PF00732.19 EFX06387.1 - 0.13 11.6 0.0 4.8 6.5 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase Mqo PF06039.15 EFX06387.1 - 0.48 8.9 1.0 0.58 8.6 0.0 1.5 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Trp_halogenase PF04820.14 EFX06387.1 - 3 6.6 8.1 1.3 7.8 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Amidase PF01425.21 EFX06390.1 - 6.6e-47 160.5 3.3 1.1e-45 156.4 1.9 2.5 1 1 1 2 2 2 2 Amidase SOG2 PF10428.9 EFX06393.1 - 4.3e-77 260.4 0.7 6.8e-51 174.0 0.1 4.7 4 2 0 5 5 5 2 RAM signalling pathway protein LRR_8 PF13855.6 EFX06393.1 - 5e-20 71.0 1.6 5.1e-10 39.0 0.2 2.5 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFX06393.1 - 2.1e-11 43.8 2.1 0.00099 19.5 0.2 3.7 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFX06393.1 - 0.003 17.5 1.6 4.9 7.5 0.0 4.0 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.33 EFX06393.1 - 0.0083 16.5 1.6 15 6.6 0.0 4.8 4 0 0 4 4 4 1 Leucine Rich Repeat TFIIA PF03153.13 EFX06393.1 - 0.35 10.8 20.5 0.71 9.8 20.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 EFX06393.1 - 0.86 8.7 12.6 1.2 8.3 10.7 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal eIF-3_zeta PF05091.12 EFX06393.1 - 2.5 7.0 5.7 3.7 6.4 5.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Clat_adaptor_s PF01217.20 EFX06395.1 - 8.3e-42 142.5 0.0 2.4e-41 141.0 0.0 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Tetraspanin PF00335.20 EFX06396.1 - 5.3e-05 23.1 0.0 0.00011 22.0 0.0 1.6 1 1 0 1 1 1 1 Tetraspanin family DUF1056 PF06341.11 EFX06397.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1056) DUF647 PF04884.14 EFX06398.1 - 7.8e-100 333.5 4.2 9.8e-100 333.1 4.2 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis GNAT_like PF18407.1 EFX06398.1 - 0.096 13.0 1.3 0.41 11.0 0.0 2.4 3 0 0 3 3 3 0 GCN5-related N-acetyltransferase like domain DUF3328 PF11807.8 EFX06399.1 - 1.8e-26 93.3 0.1 2.4e-26 92.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) RasGEF PF00617.19 EFX06400.1 - 1.9e-48 165.0 0.3 3e-48 164.4 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFX06400.1 - 1.8e-14 53.8 0.1 3.9e-14 52.8 0.1 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF974 PF06159.13 EFX06401.1 - 1.4e-77 260.8 0.0 2e-77 260.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) MMR_HSR1 PF01926.23 EFX06401.1 - 0.0032 17.5 0.0 3.5 7.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF1678 PF07913.11 EFX06402.1 - 0.065 13.0 0.9 0.2 11.4 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1678) SseC PF04888.12 EFX06402.1 - 0.19 11.3 5.7 0.37 10.3 5.7 1.5 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Dynamin_M PF01031.20 EFX06402.1 - 0.21 10.8 9.8 0.41 9.8 9.8 1.4 1 0 0 1 1 1 0 Dynamin central region DUF445 PF04286.12 EFX06402.1 - 0.37 10.5 17.2 0.85 9.4 16.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF445) SUIM_assoc PF16619.5 EFX06404.1 - 0.038 14.0 5.2 0.094 12.8 5.2 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 EFX06404.1 - 1.5 8.4 6.1 2.3 7.7 6.1 1.2 1 0 0 1 1 1 0 Spt20 family DUF917 PF06032.12 EFX06405.1 - 3.2e-120 401.2 4.1 6.5e-120 400.1 0.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 EFX06405.1 - 5.1e-28 98.0 0.3 1.1e-26 93.6 0.0 3.0 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EFX06405.1 - 6.6e-28 97.8 13.9 2.4e-25 89.4 10.2 3.5 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase Shikimate_dh_N PF08501.11 EFX06405.1 - 0.0095 16.2 0.0 0.03 14.6 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Cu_amine_oxidN1 PF07833.11 EFX06405.1 - 0.15 12.5 0.1 0.4 11.2 0.1 1.6 1 0 0 1 1 1 0 Copper amine oxidase N-terminal domain StbA PF06406.11 EFX06405.1 - 0.2 10.9 0.7 4.1 6.6 0.2 2.9 2 0 0 2 2 2 0 StbA protein FtsA PF14450.6 EFX06405.1 - 0.7 10.4 3.5 11 6.5 0.0 3.3 2 1 0 2 2 2 0 Cell division protein FtsA Lysine_decarbox PF03641.14 EFX06406.1 - 4.6e-29 101.2 0.0 6.1e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFX06406.1 - 6.9e-08 32.2 0.8 1.5e-07 31.1 0.8 1.5 1 1 0 1 1 1 1 SLOG cluster4 family Phage_SSB PF16773.5 EFX06406.1 - 0.069 13.2 0.0 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 Lactococcus phage single-stranded DNA binding protein DUF4191 PF13829.6 EFX06407.1 - 0.14 11.5 0.6 0.34 10.2 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Bcr-Abl_Oligo PF09036.10 EFX06407.1 - 6.2 6.9 13.2 2.4 8.2 2.2 3.5 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain COX7C PF02935.16 EFX06409.1 - 4.6e-19 68.4 2.2 7.2e-19 67.8 2.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc IPK PF03770.16 EFX06410.1 - 7.1e-55 185.9 0.0 1.2e-54 185.1 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase zf-C2H2 PF00096.26 EFX06411.1 - 5e-08 33.0 11.1 4e-05 23.8 1.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX06411.1 - 1.3e-07 31.8 11.3 0.00025 21.6 1.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EFX06411.1 - 0.0042 16.9 1.9 0.0092 15.9 1.9 1.6 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.6 EFX06411.1 - 0.0059 17.0 4.8 0.0059 17.0 4.8 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EFX06411.1 - 0.0064 16.7 0.7 0.12 12.7 0.1 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFX06411.1 - 0.0081 16.5 0.1 0.029 14.7 0.1 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EFX06411.1 - 0.02 14.9 0.2 0.02 14.9 0.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger PyrI_C PF02748.15 EFX06411.1 - 0.078 12.9 0.5 0.15 12.0 0.5 1.5 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain HMGL-like PF00682.19 EFX06412.1 - 1.7e-40 139.2 0.1 5.4e-29 101.6 0.0 2.5 2 0 0 2 2 2 2 HMGL-like CN_hydrolase PF00795.22 EFX06412.1 - 2.1e-29 102.7 0.0 8.3e-29 100.7 0.0 2.0 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase BPL_LplA_LipB PF03099.19 EFX06412.1 - 0.00023 21.1 0.0 0.00061 19.7 0.0 1.7 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Methyltransf_23 PF13489.6 EFX06413.1 - 4.2e-18 65.7 0.0 5.9e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX06413.1 - 2.2e-11 44.3 0.0 5.6e-11 43.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06413.1 - 3e-10 40.6 0.0 5.3e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX06413.1 - 4.9e-06 27.2 0.0 4.1e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX06413.1 - 1.6e-05 24.4 0.0 0.054 12.8 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFX06413.1 - 0.00078 19.3 0.0 0.37 10.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EFX06413.1 - 0.0026 17.3 0.0 0.009 15.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EFX06413.1 - 0.0068 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EFX06413.1 - 0.024 14.0 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EFX06413.1 - 0.025 14.3 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.12 EFX06413.1 - 0.11 12.2 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF938) FtsJ PF01728.19 EFX06413.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase MFS_1 PF07690.16 EFX06414.1 - 5.7e-46 157.1 56.1 6.9e-46 156.8 52.8 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX06414.1 - 6.1e-23 81.1 22.0 8.6e-23 80.6 22.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EFX06414.1 - 3.7e-13 49.1 31.4 2e-12 46.7 5.7 3.4 3 0 0 3 3 3 3 Sugar (and other) transporter OATP PF03137.20 EFX06414.1 - 0.019 13.2 12.6 0.13 10.5 0.0 3.6 2 2 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family Bromodomain PF00439.25 EFX06415.1 - 6.7e-08 32.5 0.1 2.2e-07 30.8 0.1 1.8 1 1 0 1 1 1 1 Bromodomain Myb_DNA-binding PF00249.31 EFX06416.1 - 1.1e-13 51.1 0.0 2.4e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFX06416.1 - 6.4e-05 22.8 0.3 6.4e-05 22.8 0.3 2.3 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFX06416.1 - 0.03 14.6 3.8 1.3 9.3 0.6 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain LRR_4 PF12799.7 EFX06417.1 - 1.2e-24 86.0 21.5 1.7e-05 25.1 0.3 8.0 4 1 6 10 10 10 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFX06417.1 - 2.2e-17 62.6 27.3 1.2e-06 28.2 2.0 6.5 4 2 2 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 EFX06417.1 - 6.7e-11 42.0 6.7 1.3e-05 24.8 0.2 3.4 1 1 0 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EFX06417.1 - 0.037 14.5 19.7 13 6.9 0.2 9.4 9 1 0 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.6 EFX06417.1 - 0.35 11.0 21.4 14 6.0 0.1 8.1 10 0 0 10 10 10 0 Leucine Rich repeat NUP50 PF08911.11 EFX06417.1 - 1.6 9.4 6.5 0.64 10.7 2.0 3.0 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) FAD_binding_3 PF01494.19 EFX06419.1 - 7.5e-18 64.9 0.0 6.8e-10 38.7 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.24 EFX06419.1 - 4.3e-06 26.3 0.0 0.00023 20.6 0.0 2.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EFX06419.1 - 0.0098 15.1 0.1 0.5 9.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFX06419.1 - 0.011 16.3 0.5 2.3 8.9 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX06419.1 - 0.018 14.3 0.4 0.74 9.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX06419.1 - 0.05 12.5 0.7 1.9 7.2 0.1 2.2 1 1 1 2 2 2 0 Tryptophan halogenase NAD_binding_8 PF13450.6 EFX06419.1 - 0.15 12.3 0.0 0.39 11.0 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RseC_MucC PF04246.12 EFX06419.1 - 0.21 11.6 1.1 0.71 9.8 0.1 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC p450 PF00067.22 EFX06420.1 - 7.7e-55 186.5 0.0 4.1e-54 184.1 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Stirrup PF09061.6 EFX06420.1 - 0.0098 16.1 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 1 Stirrup Zn_clus PF00172.18 EFX06422.1 - 9.2e-06 25.7 4.7 1.8e-05 24.8 4.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Secretin_N_2 PF07655.13 EFX06422.1 - 9.1 6.9 15.5 1.4 9.5 10.8 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain Beta-lactamase PF00144.24 EFX06423.1 - 7e-36 124.1 3.4 1.1e-35 123.5 3.4 1.3 1 0 0 1 1 1 1 Beta-lactamase DUF3990 PF13151.6 EFX06424.1 - 0.00095 18.9 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) Rtt106 PF08512.12 EFX06425.1 - 2.8e-30 104.5 0.0 8.3e-30 103.0 0.0 1.7 2 0 0 2 2 2 1 Histone chaperone Rttp106-like bPH_2 PF03703.14 EFX06425.1 - 0.014 15.6 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial PH domain PH_18 PF18469.1 EFX06425.1 - 0.028 14.4 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain AAA PF00004.29 EFX06427.1 - 5.1e-55 185.5 0.0 1.6e-38 132.1 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFX06427.1 - 1.4e-11 45.1 0.1 9.6e-05 22.8 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EFX06427.1 - 4.6e-11 43.1 0.3 0.00013 22.2 0.0 4.0 2 2 1 3 3 3 2 AAA domain AAA_lid_3 PF17862.1 EFX06427.1 - 1.8e-10 40.4 0.0 4.6e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFX06427.1 - 7.5e-08 32.5 0.0 0.002 18.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 EFX06427.1 - 1e-07 31.6 0.0 1.9e-06 27.6 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 EFX06427.1 - 2.4e-07 30.3 0.0 0.0095 15.2 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EFX06427.1 - 6.6e-07 29.9 0.0 0.013 16.1 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EFX06427.1 - 2e-06 28.0 0.0 0.087 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EFX06427.1 - 2e-06 28.0 0.0 3.5e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EFX06427.1 - 3e-06 26.8 0.1 0.0058 16.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFX06427.1 - 3.7e-06 26.8 0.0 0.088 12.5 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein RuvB_N PF05496.12 EFX06427.1 - 4e-06 26.7 0.5 0.061 13.1 0.1 3.2 3 1 1 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EFX06427.1 - 4e-06 26.7 0.0 0.0039 16.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EFX06427.1 - 9.4e-06 25.6 2.3 0.062 13.2 0.1 3.6 4 0 0 4 4 3 1 NACHT domain RNA_helicase PF00910.22 EFX06427.1 - 1.1e-05 25.8 0.0 0.024 15.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 EFX06427.1 - 1.7e-05 24.8 0.0 0.22 11.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EFX06427.1 - 2e-05 24.6 0.0 0.15 12.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EFX06427.1 - 2.2e-05 24.5 0.1 7.6 6.4 0.0 4.1 2 2 1 4 4 4 0 ATPase domain predominantly from Archaea PhoH PF02562.16 EFX06427.1 - 5.2e-05 22.8 0.4 0.073 12.5 0.0 2.7 3 0 0 3 3 3 2 PhoH-like protein AAA_7 PF12775.7 EFX06427.1 - 7.4e-05 22.3 0.3 0.077 12.5 0.0 2.7 3 0 0 3 3 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EFX06427.1 - 0.0001 22.6 0.0 0.25 11.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFX06427.1 - 0.00017 21.3 0.0 0.38 10.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 EFX06427.1 - 0.00021 20.6 0.1 0.28 10.3 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.26 EFX06427.1 - 0.00029 20.6 0.0 0.79 9.4 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 EFX06427.1 - 0.00041 19.8 1.3 0.072 12.4 0.1 2.8 2 1 1 3 3 3 1 KaiC AAA_19 PF13245.6 EFX06427.1 - 0.0005 20.4 0.1 0.54 10.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 EFX06427.1 - 0.00097 19.7 0.4 0.069 13.7 0.1 2.5 2 0 0 2 2 2 1 ABC transporter AAA_25 PF13481.6 EFX06427.1 - 0.0021 17.7 4.9 0.94 9.0 0.2 3.7 3 2 0 4 4 3 2 AAA domain DUF2075 PF09848.9 EFX06427.1 - 0.0022 17.3 0.8 0.36 10.0 0.1 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 EFX06427.1 - 0.0027 16.9 0.0 0.55 9.3 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Cytidylate_kin PF02224.18 EFX06427.1 - 0.008 15.9 0.1 1.1 9.0 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase ResIII PF04851.15 EFX06427.1 - 0.011 15.8 0.3 12 5.9 0.4 3.0 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EFX06427.1 - 0.012 15.4 0.0 0.61 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 EFX06427.1 - 0.012 15.0 0.3 7.9 5.8 0.0 3.4 3 1 1 4 4 4 0 Bacterial TniB protein AAA_17 PF13207.6 EFX06427.1 - 0.027 14.9 0.4 11 6.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EFX06427.1 - 0.032 13.3 0.0 4.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 EFX06427.1 - 0.039 13.7 0.0 6.1 6.7 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 EFX06427.1 - 0.045 13.7 0.0 8.3 6.3 0.0 2.8 3 0 0 3 3 3 0 Rad17 P-loop domain DEAD PF00270.29 EFX06427.1 - 0.045 13.5 0.6 20 4.9 0.1 3.7 2 2 2 4 4 4 0 DEAD/DEAH box helicase AAA_3 PF07726.11 EFX06427.1 - 0.072 13.0 0.0 0.44 10.4 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 EFX06427.1 - 0.13 12.3 0.0 33 4.6 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFX06427.1 - 0.15 11.3 0.1 12 5.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin IPT PF01745.16 EFX06427.1 - 0.15 11.4 0.3 1.5 8.2 0.1 2.2 2 0 0 2 2 2 0 Isopentenyl transferase FAD_binding_3 PF01494.19 EFX06428.1 - 2.6e-17 63.1 0.0 1.2e-11 44.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFX06428.1 - 1.9e-06 27.7 5.6 0.014 15.0 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX06428.1 - 2.9e-06 26.7 0.3 0.002 17.4 0.6 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX06428.1 - 2.4e-05 23.6 3.5 4.1e-05 22.9 3.1 1.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFX06428.1 - 2.8e-05 24.3 2.5 0.00027 21.1 1.7 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFX06428.1 - 8.1e-05 21.8 0.4 0.00015 20.9 0.4 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EFX06428.1 - 0.019 13.7 0.6 0.16 10.6 0.9 1.9 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 EFX06428.1 - 0.026 13.9 2.0 0.05 12.9 2.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Rossmann-like PF10727.9 EFX06428.1 - 0.06 13.2 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 Rossmann-like domain Amino_oxidase PF01593.24 EFX06428.1 - 0.079 12.2 0.7 11 5.2 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.22 EFX06428.1 - 0.11 11.6 2.1 0.19 10.8 2.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 EFX06428.1 - 0.12 11.6 0.6 0.24 10.6 0.6 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EFX06428.1 - 0.34 10.1 0.9 0.67 9.1 0.9 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ceramidase PF05875.12 EFX06429.1 - 1.4e-52 178.8 6.5 1.6e-52 178.5 6.5 1.1 1 0 0 1 1 1 1 Ceramidase TrkA_C PF02080.21 EFX06430.1 - 0.079 12.8 0.1 4.9 7.1 0.0 2.1 2 0 0 2 2 2 0 TrkA-C domain Sulfatase PF00884.23 EFX06431.1 - 1.1e-61 209.0 1.2 1.6e-61 208.4 1.2 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFX06431.1 - 0.00016 21.4 2.4 0.0055 16.4 2.5 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EFX06431.1 - 0.0078 16.5 0.2 0.017 15.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Esterase_phd PF10503.9 EFX06432.1 - 0.00028 20.5 0.1 0.00052 19.6 0.1 1.5 1 1 0 1 1 1 1 Esterase PHB depolymerase AXE1 PF05448.12 EFX06432.1 - 0.00044 19.0 0.0 0.0012 17.6 0.0 1.6 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 EFX06432.1 - 0.00046 19.7 0.1 0.00089 18.8 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EFX06432.1 - 0.003 17.4 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EFX06432.1 - 0.0073 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 EFX06432.1 - 0.15 11.6 0.1 0.36 10.3 0.1 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family Bromodomain PF00439.25 EFX06434.1 - 2.6e-36 123.6 0.6 5.7e-21 74.4 0.0 3.2 3 0 0 3 3 3 2 Bromodomain BET PF17035.5 EFX06434.1 - 5.3e-06 26.5 0.6 1.2e-05 25.3 0.6 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Cnn_1N PF07989.11 EFX06435.1 - 2.9e-06 27.3 13.2 7e-06 26.1 13.2 1.7 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 Tmemb_cc2 PF10267.9 EFX06435.1 - 9.4 5.3 13.7 0.72 8.9 5.5 2.3 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DNA_pol_A_exo1 PF01612.20 EFX06436.1 - 4.6e-07 29.7 0.0 6.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease AAA PF00004.29 EFX06437.1 - 7.7e-44 149.3 0.0 1.3e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX06437.1 - 1.9e-14 53.2 0.0 4.3e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFX06437.1 - 1.1e-07 31.9 0.0 2.7e-07 30.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFX06437.1 - 1.4e-07 31.8 0.0 2.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Prot_ATP_ID_OB PF16450.5 EFX06437.1 - 3.5e-06 26.9 3.0 9.2e-06 25.5 3.0 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EFX06437.1 - 4.4e-06 27.2 0.0 0.00011 22.6 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFX06437.1 - 2.5e-05 24.6 0.2 0.006 16.9 0.2 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFX06437.1 - 5.8e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFX06437.1 - 0.00057 20.4 0.0 0.019 15.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFX06437.1 - 0.001 18.4 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EFX06437.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFX06437.1 - 0.0028 17.4 0.0 0.0052 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EFX06437.1 - 0.0032 17.3 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFX06437.1 - 0.0081 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EFX06437.1 - 0.0087 15.4 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 KaiC TsaE PF02367.17 EFX06437.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFX06437.1 - 0.011 16.0 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Prot_ATP_OB_N PF17758.1 EFX06437.1 - 0.012 15.3 0.2 0.045 13.4 0.2 2.1 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain DUF815 PF05673.13 EFX06437.1 - 0.021 14.0 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EFX06437.1 - 0.023 14.4 0.0 0.097 12.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EFX06437.1 - 0.027 14.0 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EFX06437.1 - 0.03 13.8 0.0 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EFX06437.1 - 0.031 14.0 0.0 0.1 12.3 0.0 1.9 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.6 EFX06437.1 - 0.034 14.2 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFX06437.1 - 0.035 14.5 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EFX06437.1 - 0.052 13.1 0.1 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EFX06437.1 - 0.061 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 HR1 PF02185.16 EFX06437.1 - 0.072 13.2 1.6 0.17 12.0 1.6 1.6 1 0 0 1 1 1 0 Hr1 repeat Zeta_toxin PF06414.12 EFX06437.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Patatin PF01734.22 EFX06438.1 - 7.4e-14 52.4 0.0 4.5e-13 49.9 0.0 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase RVT_thumb PF06817.14 EFX06439.1 - 0.11 12.4 0.0 3.6 7.5 0.0 2.2 2 0 0 2 2 2 0 Reverse transcriptase thumb domain HRG PF16954.5 EFX06440.1 - 0.23 11.9 0.3 0.23 11.9 0.3 1.8 2 0 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene THRAP3_BCLAF1 PF15440.6 EFX06440.1 - 9 5.2 8.6 16 4.3 8.6 1.3 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Metallophos PF00149.28 EFX06441.1 - 3.4e-33 115.9 0.2 5.6e-33 115.2 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EFX06441.1 - 0.008 15.8 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain JmjN PF02375.17 EFX06441.1 - 0.077 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 jmjN domain Glyco_hydro_12 PF01670.16 EFX06442.1 - 5.4e-49 167.1 9.9 1.5e-48 165.6 9.9 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 CBM_1 PF00734.18 EFX06442.1 - 2.2e-10 40.3 13.3 2.2e-10 40.3 13.3 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain SDA1 PF05285.12 EFX06443.1 - 4.7e-80 269.6 62.4 4.7e-80 269.6 62.4 2.9 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EFX06443.1 - 7e-19 67.9 0.0 2.1e-18 66.4 0.0 1.9 1 0 0 1 1 1 1 NUC130/3NT domain LRR_6 PF13516.6 EFX06446.1 - 0.056 13.5 3.8 6.1 7.2 0.0 4.1 5 0 0 5 5 5 0 Leucine Rich repeat Y_phosphatase2 PF03162.13 EFX06447.1 - 1.8e-45 154.5 0.0 2.8e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFX06447.1 - 1.4e-12 48.1 0.0 4.7e-12 46.4 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFX06447.1 - 0.0026 17.4 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFX06447.1 - 0.0036 17.1 0.0 0.0068 16.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain MliC PF09864.9 EFX06447.1 - 0.13 12.2 0.1 0.32 11.0 0.1 1.6 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme DUF1768 PF08719.11 EFX06448.1 - 1e-50 172.1 0.1 1.3e-50 171.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) MINDY_DUB PF04424.13 EFX06449.1 - 4.6e-24 84.7 0.0 7.3e-24 84.0 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase GCN5L1 PF06320.13 EFX06450.1 - 3.8e-11 43.1 0.3 3.8e-11 43.1 0.3 2.2 3 0 0 3 3 3 1 GCN5-like protein 1 (GCN5L1) Ribosomal_L37 PF08561.10 EFX06452.1 - 1.5 9.4 6.6 0.27 11.8 0.9 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 CDC73_N PF16050.5 EFX06452.1 - 6.8 5.9 6.8 22 4.3 0.2 3.0 3 0 0 3 3 3 0 Paf1 complex subunit CDC73 N-terminal LysM PF01476.20 EFX06453.1 - 1.5e-19 69.8 4.5 7e-06 26.0 0.0 5.7 6 0 0 6 6 6 4 LysM domain ArsB PF02040.15 EFX06454.1 - 9e-12 45.0 19.2 1.6e-07 31.0 7.0 2.3 2 0 0 2 2 2 2 Arsenical pump membrane protein adh_short PF00106.25 EFX06455.1 - 1.6e-18 66.9 0.6 1.7e-13 50.5 0.7 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX06455.1 - 8.7e-14 51.6 1.2 3.8e-10 39.7 1.7 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX06455.1 - 0.00018 21.5 0.4 0.00031 20.7 0.4 1.4 1 0 0 1 1 1 1 KR domain cobW PF02492.19 EFX06456.1 - 2.8e-34 118.3 0.0 3.7e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EFX06456.1 - 4e-05 22.7 0.5 0.013 14.5 0.1 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EFX06456.1 - 0.0039 17.7 0.0 0.0056 17.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFX06456.1 - 0.0085 16.2 0.0 0.035 14.2 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase BNR PF02012.20 EFX06456.1 - 0.054 13.5 2.3 23 5.6 0.1 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat ResIII PF04851.15 EFX06456.1 - 0.18 11.8 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Pyr_redox_2 PF07992.14 EFX06457.1 - 2.7e-43 148.3 0.2 6.4e-43 147.1 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFX06457.1 - 1.3e-32 112.3 1.0 5.9e-32 110.2 0.4 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFX06457.1 - 7.1e-17 61.7 0.0 2.5e-16 60.0 0.0 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Helicase_C PF00271.31 EFX06457.1 - 2.1e-14 53.8 0.0 1.3e-12 48.0 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pyr_redox_3 PF13738.6 EFX06457.1 - 6.2e-10 38.8 0.0 9.6e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase RecQ_Zn_bind PF16124.5 EFX06457.1 - 8.9e-05 23.1 0.1 0.00025 21.7 0.1 1.8 1 0 0 1 1 1 1 RecQ zinc-binding DEAD PF00270.29 EFX06457.1 - 9.1e-05 22.3 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase K_oxygenase PF13434.6 EFX06457.1 - 0.015 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) OPT PF03169.15 EFX06458.1 - 1.8e-125 420.0 40.4 2e-125 419.8 40.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Methyltransf_23 PF13489.6 EFX06460.1 - 1.8e-23 83.2 0.0 2.7e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX06460.1 - 3.6e-10 39.8 0.0 1.9e-06 27.8 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EFX06460.1 - 3.5e-07 30.8 0.0 1.4e-06 28.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06460.1 - 3.1e-06 27.8 0.0 7.4e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX06460.1 - 0.015 16.0 0.0 0.15 12.8 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 EFX06460.1 - 0.039 13.4 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain SPX PF03105.19 EFX06461.1 - 4.9e-42 145.2 0.0 1e-27 98.1 0.0 2.2 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 EFX06461.1 - 2.7e-35 122.4 34.1 3.8e-35 121.8 34.1 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EFX06461.1 - 3.1e-27 95.6 36.1 3.1e-27 95.6 36.1 2.3 2 1 1 3 3 3 2 Citrate transporter UL42 PF17638.2 EFX06461.1 - 3.8 7.5 7.4 14 5.7 7.4 2.0 1 0 0 1 1 1 0 HCMV UL42 Fe-S_biosyn PF01521.20 EFX06462.1 - 9.4e-18 64.4 0.0 1.2e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Myb_DNA-binding PF00249.31 EFX06463.1 - 3.2e-32 110.5 0.2 1.1e-13 51.1 0.0 3.4 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFX06463.1 - 1.2e-27 95.9 0.0 9.6e-10 38.6 0.0 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 EFX06463.1 - 0.0006 19.8 0.0 5.1 7.1 0.0 3.1 1 1 2 3 3 3 3 SLIDE Myb_DNA-bind_7 PF15963.5 EFX06463.1 - 0.042 13.8 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 Myb DNA-binding like HATPase_c_3 PF13589.6 EFX06464.1 - 3.5e-05 23.6 0.0 6.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFX06464.1 - 0.00021 21.8 0.0 0.00032 21.2 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ADC PF06314.11 EFX06465.1 - 2e-42 145.4 0.0 2.5e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Zn_clus PF00172.18 EFX06466.1 - 0.0046 17.0 7.4 0.01 15.9 7.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M28 PF04389.17 EFX06467.1 - 1.1e-25 90.5 0.0 1.6e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFX06467.1 - 1.9e-09 37.4 1.9 3.3e-09 36.6 1.9 1.4 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EFX06467.1 - 0.00097 18.9 0.0 0.004 16.9 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 DENN PF02141.21 EFX06468.1 - 5.2e-57 192.8 0.0 8e-57 192.2 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EFX06468.1 - 1.1e-14 54.9 0.0 2.6e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EFX06468.1 - 5.4e-14 51.9 0.9 1.3e-13 50.7 0.9 1.7 1 0 0 1 1 1 1 dDENN domain CHAT PF12770.7 EFX06468.1 - 0.029 13.8 0.0 0.065 12.6 0.0 1.5 1 0 0 1 1 1 0 CHAT domain C1_2 PF03107.16 EFX06468.1 - 0.039 14.3 10.4 0.085 13.2 10.4 1.5 1 0 0 1 1 1 0 C1 domain SPA PF08616.10 EFX06468.1 - 0.067 13.2 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Stabilization of polarity axis C1_1 PF00130.22 EFX06468.1 - 0.28 11.1 10.8 0.53 10.2 10.8 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EFX06468.1 - 0.87 9.5 9.8 2 8.4 9.8 1.6 1 0 0 1 1 1 0 PHD-finger COesterase PF00135.28 EFX06469.1 - 1.4e-72 245.3 0.0 1.8e-72 244.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFX06469.1 - 0.3 10.9 1.7 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold ERCC4 PF02732.15 EFX06470.1 - 1.6e-18 67.4 0.0 3.6e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain Pinin_SDK_memA PF04696.13 EFX06470.1 - 0.12 12.4 16.6 0.34 11.0 16.6 1.7 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region eIF3_subunit PF08597.10 EFX06470.1 - 0.55 10.1 18.1 1.1 9.1 18.1 1.5 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Borrelia_P83 PF05262.11 EFX06470.1 - 0.81 8.1 13.3 1.2 7.5 13.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein NARP1 PF12569.8 EFX06470.1 - 1.6 7.5 11.0 2.5 6.9 11.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 EFX06470.1 - 2.1 6.5 9.4 3.3 5.9 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein CBM-like PF14683.6 EFX06471.1 - 3.7e-27 95.2 0.1 9.3e-27 93.9 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EFX06471.1 - 2.6e-14 52.8 1.8 9.2e-14 51.0 1.8 2.0 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EFX06471.1 - 2.6e-10 40.4 1.1 6.7e-10 39.1 1.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFX06471.1 - 0.0017 18.3 0.2 0.023 14.7 0.2 2.6 2 1 0 2 2 2 1 CarboxypepD_reg-like domain SpaA PF17802.1 EFX06471.1 - 0.085 13.2 0.1 0.26 11.6 0.1 1.8 1 0 0 1 1 1 0 Prealbumin-like fold domain DUF2012 PF09430.10 EFX06471.1 - 0.13 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Pirin PF02678.16 EFX06472.1 - 3.5e-30 104.2 0.0 6.5e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EFX06472.1 - 1.9e-23 82.8 0.0 1.3e-21 76.8 0.0 2.3 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EFX06472.1 - 5.8e-07 29.1 1.5 5.6e-06 26.0 0.5 2.6 2 1 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 EFX06472.1 - 0.011 15.5 0.1 0.13 11.9 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF861) DS PF01916.17 EFX06473.1 - 8.6e-130 432.2 0.0 1e-129 431.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase V-SNARE PF05008.15 EFX06474.1 - 4.1e-22 78.4 0.7 1.2e-21 76.8 0.7 1.9 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EFX06474.1 - 1.2e-18 67.2 3.0 3.4e-18 65.7 3.0 1.9 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF726 PF05277.12 EFX06474.1 - 4e-18 65.5 0.0 6.2e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Sec20 PF03908.13 EFX06474.1 - 0.01 15.7 0.8 0.027 14.4 0.8 1.7 1 0 0 1 1 1 0 Sec20 Synaptobrevin PF00957.21 EFX06474.1 - 0.03 14.1 1.3 0.056 13.2 0.4 1.9 1 1 1 2 2 2 0 Synaptobrevin FAM76 PF16046.5 EFX06474.1 - 0.075 12.4 0.2 0.17 11.2 0.2 1.6 1 0 0 1 1 1 0 FAM76 protein Fusion_gly PF00523.18 EFX06474.1 - 0.13 10.5 0.6 0.23 9.7 0.6 1.4 1 0 0 1 1 1 0 Fusion glycoprotein F0 SNARE PF05739.19 EFX06474.1 - 0.18 11.8 3.1 0.11 12.4 0.5 2.1 2 0 0 2 2 2 0 SNARE domain DUF4407 PF14362.6 EFX06474.1 - 1.2 8.4 13.0 0.029 13.7 5.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF1542 PF07564.11 EFX06474.1 - 1.3 9.1 4.2 7.9 6.7 0.2 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) Use1 PF09753.9 EFX06474.1 - 1.8 8.2 5.9 20 4.8 5.9 2.6 1 1 0 1 1 1 0 Membrane fusion protein Use1 DUF1674 PF07896.12 EFX06475.1 - 9.1e-16 58.1 4.4 2.3e-15 56.8 4.4 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Cu_amine_oxid PF01179.20 EFX06476.1 - 3.8e-155 516.8 0.0 6.2e-155 516.1 0.0 1.3 1 1 0 1 1 1 1 Copper amine oxidase, enzyme domain SGL PF08450.12 EFX06476.1 - 4.1e-44 151.0 0.3 6.6e-44 150.3 0.3 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Cu_amine_oxidN2 PF02727.16 EFX06476.1 - 0.00021 21.5 0.0 0.00042 20.5 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain TssO PF17561.2 EFX06477.1 - 0.096 12.8 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO Amnionless PF14828.6 EFX06478.1 - 0.011 14.5 0.0 0.014 14.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless HemY_N PF07219.13 EFX06478.1 - 0.028 14.6 0.1 0.028 14.6 0.1 2.5 2 1 1 3 3 3 0 HemY protein N-terminus Ctr PF04145.15 EFX06478.1 - 0.054 14.1 1.3 0.31 11.7 0.0 2.1 1 1 1 2 2 2 0 Ctr copper transporter family TMEM65 PF10507.9 EFX06478.1 - 0.15 12.0 0.1 0.32 11.0 0.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 65 Striatin PF08232.12 EFX06479.1 - 3.6e-40 138.1 0.6 8.3e-40 136.9 0.6 1.6 1 0 0 1 1 1 1 Striatin family WD40 PF00400.32 EFX06479.1 - 1.9e-25 88.6 21.1 0.00018 22.2 0.1 7.9 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX06479.1 - 4.8e-05 23.6 0.1 0.56 10.5 0.0 4.6 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFX06479.1 - 0.053 12.5 0.1 0.78 8.6 0.0 2.8 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CALCOCO1 PF07888.11 EFX06479.1 - 0.12 11.2 3.6 0.19 10.6 3.6 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADH_N_2 PF16884.5 EFX06479.1 - 0.18 11.7 0.1 0.5 10.3 0.0 1.7 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase DUF4482 PF14818.6 EFX06479.1 - 0.52 11.2 4.4 0.22 12.4 1.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Trypan_PARP PF05887.11 EFX06481.1 - 0.0042 17.1 29.0 0.01 15.8 29.0 1.6 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Neisseria_TspB PF05616.13 EFX06481.1 - 0.15 10.5 10.7 0.23 9.9 10.7 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Nucleo_P87 PF07267.11 EFX06481.1 - 9.9 4.9 11.5 14 4.4 11.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Fungal_trans PF04082.18 EFX06482.1 - 1.7e-14 53.5 0.0 2.7e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06482.1 - 5.9e-07 29.5 7.0 1.2e-06 28.6 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med3 PF11593.8 EFX06482.1 - 0.17 11.0 0.7 0.28 10.3 0.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4050 PF13259.6 EFX06483.1 - 1.7e-57 194.7 0.0 1.7e-57 194.7 0.0 3.4 3 1 0 3 3 3 1 Protein of unknown function (DUF4050) EF-hand_6 PF13405.6 EFX06484.1 - 2.9e-08 33.0 0.1 0.0073 16.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFX06484.1 - 1.6e-05 24.1 0.2 8.8e-05 21.8 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 EFX06484.1 - 5.9e-05 22.3 0.4 0.0026 17.2 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EFX06484.1 - 0.00015 22.1 0.1 0.00034 21.0 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair MRC1 PF09444.10 EFX06484.1 - 0.078 13.5 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 MRC1-like domain EF-hand_8 PF13833.6 EFX06484.1 - 0.13 12.2 0.1 7.1 6.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair Methyltransf_23 PF13489.6 EFX06485.1 - 4.7e-20 72.1 0.0 7.1e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX06485.1 - 4.9e-15 56.0 0.0 2.2e-14 53.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06485.1 - 5.3e-15 55.8 0.0 1.2e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX06485.1 - 8.8e-11 42.4 0.0 6.4e-10 39.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX06485.1 - 4.7e-09 36.2 0.0 0.0032 17.3 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EFX06485.1 - 2.5e-07 30.3 0.0 8.6e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFX06485.1 - 0.0069 15.9 0.0 0.04 13.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EFX06485.1 - 0.014 15.5 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EFX06485.1 - 0.017 14.6 0.0 0.042 13.3 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_16 PF10294.9 EFX06485.1 - 0.042 13.6 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.12 EFX06485.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_8 PF05148.15 EFX06485.1 - 0.15 11.9 0.0 0.52 10.1 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase PNP_UDP_1 PF01048.20 EFX06486.1 - 1.4e-12 47.4 1.7 1.1e-11 44.5 1.7 2.3 1 1 0 1 1 1 1 Phosphorylase superfamily DUF3328 PF11807.8 EFX06487.1 - 3.8e-25 89.0 0.0 4.9e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) GET2 PF08690.10 EFX06488.1 - 3.1e-35 122.4 0.0 4.2e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 NUC173 PF08161.12 EFX06489.1 - 4.8e-70 235.4 0.0 3.5e-67 226.0 0.0 3.5 3 0 0 3 3 3 2 NUC173 domain HEAT PF02985.22 EFX06489.1 - 0.00034 20.6 1.0 1.6 9.2 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 EFX06489.1 - 0.028 14.8 10.4 0.079 13.4 0.5 4.5 4 1 0 4 4 4 0 HEAT repeats Q_salvage PF10343.9 EFX06490.1 - 2.9e-125 417.5 0.0 3.4e-125 417.3 0.0 1.0 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family Peptidase_M1 PF01433.20 EFX06492.1 - 2.2e-79 266.0 0.2 3.1e-79 265.6 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFX06492.1 - 2.9e-64 217.6 0.3 1.4e-63 215.3 0.2 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFX06492.1 - 6.7e-41 140.5 0.1 1.1e-39 136.5 0.0 2.4 2 1 0 2 2 2 1 Peptidase M1 N-terminal domain DUF2525 PF10733.9 EFX06492.1 - 0.13 12.6 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2525) Fungal_trans PF04082.18 EFX06493.1 - 2.7e-19 69.2 0.0 4e-18 65.4 0.0 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06493.1 - 3.1e-09 36.8 9.6 5.4e-09 36.0 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Thr_synth_N PF14821.6 EFX06494.1 - 3.2e-27 94.6 0.0 7.9e-27 93.3 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EFX06494.1 - 2.4e-17 63.3 0.1 3.1e-16 59.7 0.1 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Clr5 PF14420.6 EFX06495.1 - 1.1e-09 38.4 0.0 1.9e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Clr5 domain Meleagrin PF08189.11 EFX06496.1 - 0.18 11.5 2.2 0.22 11.2 0.6 2.0 2 0 0 2 2 2 0 Meleagrin/Cygnin family DUF4680 PF15730.5 EFX06496.1 - 1.1 9.7 5.5 1.8 8.9 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) CorA PF01544.18 EFX06497.1 - 4.4e-06 26.2 2.2 1.6e-05 24.3 2.2 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein HCV_NS2 PF01538.18 EFX06497.1 - 0.044 13.4 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 Zn_clus PF00172.18 EFX06499.1 - 2.1e-07 30.9 9.3 2.1e-07 30.9 9.3 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EFX06499.1 - 2.2e-06 26.9 0.0 4.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Opi1 PF08618.10 EFX06499.1 - 5 6.3 12.1 1.6 7.9 6.5 2.5 2 1 0 2 2 2 0 Transcription factor Opi1 HEAT_2 PF13646.6 EFX06500.1 - 2.2e-19 69.6 31.6 1.8e-09 37.9 2.7 5.3 2 1 4 6 6 5 5 HEAT repeats NACHT PF05729.12 EFX06500.1 - 4.8e-18 65.6 0.0 1.1e-17 64.4 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Cnd1 PF12717.7 EFX06500.1 - 6.8e-11 42.5 5.4 0.031 14.3 0.0 4.6 2 1 2 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFX06500.1 - 4e-08 32.8 14.4 4.7 7.7 0.0 8.2 7 0 0 7 7 7 1 HEAT repeat NLRC4_HD2 PF17776.1 EFX06500.1 - 1.1e-06 29.3 0.5 3.4e-06 27.6 0.5 1.9 1 0 0 1 1 1 1 NLRC4 helical domain HD2 CTP_transf_3 PF02348.19 EFX06500.1 - 4.1e-05 23.6 1.3 0.016 15.1 0.1 2.5 1 1 1 2 2 2 2 Cytidylyltransferase NB-ARC PF00931.22 EFX06500.1 - 6.7e-05 22.2 0.0 0.00017 20.9 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain Adaptin_N PF01602.20 EFX06500.1 - 0.00011 21.0 8.7 0.24 9.9 0.2 3.3 1 1 2 3 3 3 3 Adaptin N terminal region RTP1_C1 PF10363.9 EFX06500.1 - 0.00014 22.0 2.2 0.38 10.9 0.7 4.4 3 1 0 3 3 1 1 Required for nuclear transport of RNA pol II C-terminus 1 AAA_22 PF13401.6 EFX06500.1 - 0.0008 19.7 0.3 0.037 14.3 0.0 3.1 2 1 0 2 2 2 1 AAA domain Cohesin_HEAT PF12765.7 EFX06500.1 - 0.0018 18.5 13.4 1.8 8.9 0.8 6.2 7 0 0 7 7 7 2 HEAT repeat associated with sister chromatid cohesion AAA_18 PF13238.6 EFX06500.1 - 0.0029 18.2 0.0 0.023 15.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFX06500.1 - 0.0033 17.8 0.0 0.0033 17.8 0.0 3.8 2 2 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 EFX06500.1 - 0.0049 17.3 0.0 0.023 15.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Abhydrolase_6 PF12697.7 EFX06500.1 - 0.0078 16.8 0.1 0.028 15.0 0.1 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family NTPase_1 PF03266.15 EFX06500.1 - 0.028 14.3 1.0 0.11 12.4 0.2 2.3 2 1 1 3 3 2 0 NTPase Dopey_N PF04118.14 EFX06500.1 - 0.029 13.5 0.5 0.54 9.3 0.1 2.9 3 1 0 3 3 3 0 Dopey, N-terminal HEAT_EZ PF13513.6 EFX06500.1 - 0.037 14.6 20.3 0.65 10.6 0.0 6.4 3 2 4 7 7 7 0 HEAT-like repeat AAA_14 PF13173.6 EFX06500.1 - 0.16 12.0 0.0 1 9.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain PSII_Pbs27 PF13326.6 EFX06500.1 - 0.2 12.0 6.9 87 3.4 0.1 5.4 5 0 0 5 5 5 0 Photosystem II Pbs27 Arm PF00514.23 EFX06500.1 - 0.22 11.6 0.5 81 3.5 0.1 4.1 4 0 0 4 4 3 0 Armadillo/beta-catenin-like repeat Pigment_DH PF06324.11 EFX06500.1 - 0.44 10.7 2.8 84 3.6 0.0 4.9 7 0 0 7 7 7 0 Pigment-dispersing hormone (PDH) HR1 PF02185.16 EFX06500.1 - 7.7 6.7 10.0 1.3e+02 2.8 0.1 5.5 2 1 4 6 6 6 0 Hr1 repeat DUF1992 PF09350.10 EFX06501.1 - 1.2e-18 67.0 0.2 2.8e-18 65.8 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) MgsA_C PF12002.8 EFX06502.1 - 1.3e-59 200.9 0.1 2.4e-59 200.0 0.1 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EFX06502.1 - 7e-23 80.8 0.1 1.9e-22 79.4 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EFX06502.1 - 6.3e-14 52.5 0.0 1.2e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFX06502.1 - 2.2e-09 37.2 0.0 4.6e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EFX06502.1 - 3.7e-07 30.0 0.1 2.2e-05 24.2 0.1 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EFX06502.1 - 1.6e-05 25.4 1.9 0.0086 16.5 0.0 3.1 2 2 1 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.21 EFX06502.1 - 4e-05 23.1 0.1 0.065 12.6 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EFX06502.1 - 9.6e-05 22.7 0.1 0.00033 21.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFX06502.1 - 0.00029 20.9 0.0 0.00053 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFX06502.1 - 0.00047 20.2 0.0 0.0029 17.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFX06502.1 - 0.0011 18.2 0.0 0.0017 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EFX06502.1 - 0.0038 16.5 0.0 0.0064 15.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 EFX06502.1 - 0.0046 16.8 0.0 0.017 15.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EFX06502.1 - 0.0086 16.1 0.3 1.4 8.9 0.0 2.8 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit RNF220 PF15926.5 EFX06502.1 - 0.011 15.4 0.1 0.018 14.7 0.1 1.4 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 AAA_19 PF13245.6 EFX06502.1 - 0.023 15.0 0.2 0.13 12.6 0.1 2.0 1 1 1 2 2 2 0 AAA domain SKI PF01202.22 EFX06502.1 - 0.035 14.2 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate kinase DNA_pol3_delta2 PF13177.6 EFX06502.1 - 0.037 13.8 0.0 1.4 8.7 0.0 2.2 1 1 1 2 2 2 0 DNA polymerase III, delta subunit Sigma54_activ_2 PF14532.6 EFX06502.1 - 0.043 13.9 0.0 0.085 13.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain CPT PF07931.12 EFX06502.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.6 EFX06502.1 - 0.079 13.5 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFX06502.1 - 0.079 13.2 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFX06502.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EFX06502.1 - 0.14 11.6 0.0 0.39 10.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein Pho88 PF10032.9 EFX06503.1 - 2.8e-81 271.1 0.0 3.2e-81 271.0 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Atg8 PF02991.16 EFX06504.1 - 1.2e-50 170.1 0.2 1.4e-50 169.8 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EFX06504.1 - 3.8e-07 30.4 0.0 4.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Band_7 PF01145.25 EFX06505.1 - 6.8e-29 101.1 3.3 1.1e-28 100.5 3.3 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EFX06505.1 - 0.0072 16.0 0.6 0.011 15.4 0.6 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family T3SS_needle_E PF08988.10 EFX06505.1 - 0.073 13.2 0.2 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Pyr_redox_2 PF07992.14 EFX06506.1 - 1.5e-13 50.6 0.0 1.6e-11 44.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFX06506.1 - 4.4e-12 45.2 0.1 9.6e-11 40.8 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX06506.1 - 6.5e-12 45.3 0.0 9.7e-11 41.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX06506.1 - 9.9e-07 28.9 0.1 3.4e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFX06506.1 - 2.7e-05 23.5 0.0 0.00044 19.5 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.19 EFX06506.1 - 0.017 14.5 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EFX06506.1 - 0.033 14.2 0.9 1.1 9.2 0.1 3.2 3 1 0 3 3 3 0 FAD-NAD(P)-binding DAO PF01266.24 EFX06506.1 - 0.079 12.5 0.9 6.6 6.2 0.1 3.4 2 1 1 3 3 3 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFX06506.1 - 0.13 12.8 0.2 3.4 8.3 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 EFX06507.1 - 2e-25 89.7 0.0 3.3e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFX06507.1 - 6.8e-14 51.8 0.0 1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HET PF06985.11 EFX06507.1 - 0.00034 21.0 0.0 0.00082 19.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) His_Phos_2 PF00328.22 EFX06508.1 - 2.5e-08 33.7 1.3 1.5e-07 31.1 1.3 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Phage_holin_2_4 PF16082.5 EFX06508.1 - 0.041 13.6 1.2 0.11 12.3 1.2 1.7 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like LIM_bind PF01803.16 EFX06510.1 - 2e-58 197.8 0.0 2e-58 197.8 0.0 4.3 2 1 0 3 3 3 1 LIM-domain binding protein Plasmodium_HRP PF05403.11 EFX06510.1 - 0.35 10.6 42.7 0.56 10.0 42.7 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) HET PF06985.11 EFX06511.1 - 1.3e-29 103.5 2.1 1.3e-29 103.5 2.1 2.0 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) PRKCSH PF07915.13 EFX06512.1 - 2.9e-20 73.1 1.2 5.4e-20 72.2 1.2 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein GST_N_3 PF13417.6 EFX06513.1 - 0.0026 18.1 0.0 0.006 17.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFX06513.1 - 0.0033 17.8 0.0 0.0061 16.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PPR_2 PF13041.6 EFX06514.1 - 3e-14 52.9 0.0 3.2e-05 24.0 0.0 4.4 3 1 1 4 4 4 4 PPR repeat family PPR PF01535.20 EFX06514.1 - 2.5e-11 43.0 1.6 0.0001 22.3 0.0 4.8 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.6 EFX06514.1 - 3.9e-07 30.0 0.0 0.082 13.0 0.0 3.8 3 1 0 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFX06514.1 - 3e-05 23.6 0.9 2.3 8.0 0.1 4.3 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 EFX06514.1 - 0.011 15.1 0.1 0.022 14.1 0.1 1.5 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP Ldi PF18566.1 EFX06514.1 - 0.019 14.4 0.3 1.5 8.2 0.1 2.3 1 1 1 2 2 2 0 Linalool dehydratase/isomerase LsmAD PF06741.13 EFX06516.1 - 7.6e-28 96.9 1.1 7.6e-28 96.9 1.1 2.0 3 0 0 3 3 3 1 LsmAD domain CVNH PF08881.10 EFX06518.1 - 1.9e-27 95.9 0.6 2.6e-27 95.5 0.0 1.5 2 0 0 2 2 2 1 CVNH domain LysM PF01476.20 EFX06518.1 - 3.7e-13 49.3 0.0 7.1e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.15 EFX06518.1 - 1.9e-08 34.0 13.3 1.9e-08 34.0 13.3 3.1 4 0 0 4 4 4 1 Glycine zipper 2TM domain DUF456 PF04306.13 EFX06518.1 - 0.16 12.2 1.9 0.26 11.6 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) TraT PF05818.12 EFX06518.1 - 1.2 8.8 3.5 2.3 7.8 3.5 1.5 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF2076 PF09849.9 EFX06518.1 - 1.9 8.5 9.4 3.4 7.6 9.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DDRGK PF09756.9 EFX06518.1 - 2.2 7.8 10.6 33 4.0 11.9 1.9 2 0 0 2 2 2 0 DDRGK domain VIT1 PF01988.19 EFX06521.1 - 2.5e-74 249.8 1.1 3e-74 249.5 1.1 1.0 1 0 0 1 1 1 1 VIT family SieB PF14163.6 EFX06521.1 - 0.031 13.8 0.1 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 Super-infection exclusion protein B 7TMR-DISM_7TM PF07695.11 EFX06521.1 - 0.031 14.2 4.0 0.058 13.3 4.0 1.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling PDGLE PF13190.6 EFX06521.1 - 0.07 13.0 0.0 0.33 10.9 0.0 2.1 1 1 0 1 1 1 0 PDGLE domain SpoVAC_SpoVAEB PF03862.13 EFX06521.1 - 0.075 13.3 5.9 0.16 12.2 5.9 1.6 1 0 0 1 1 1 0 SpoVAC/SpoVAEB sporulation membrane protein TBCA PF02970.16 EFX06521.1 - 0.31 11.4 4.1 0.51 10.7 4.1 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A Sec6 PF06046.13 EFX06522.1 - 7.1e-160 533.1 0.0 1.1e-159 532.5 0.0 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.12 EFX06522.1 - 0.0016 17.5 4.2 0.0016 17.5 4.2 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal TBCC_N PF16752.5 EFX06522.1 - 0.058 13.8 5.6 1.3 9.5 0.9 3.8 2 1 1 3 3 3 0 Tubulin-specific chaperone C N-terminal domain Sds3 PF08598.11 EFX06522.1 - 0.068 13.2 0.5 0.23 11.5 0.5 1.9 1 1 0 1 1 1 0 Sds3-like DUF755 PF05501.11 EFX06522.1 - 0.12 12.7 0.5 0.23 11.8 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) XPA_C PF05181.12 EFX06523.1 - 4.9e-27 93.7 2.4 9.6e-27 92.7 2.4 1.5 1 0 0 1 1 1 1 XPA protein C-terminus ArfGap PF01412.18 EFX06523.1 - 0.028 14.5 2.9 0.028 14.5 2.9 2.3 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf DUF5540 PF17694.1 EFX06523.1 - 0.17 12.5 1.7 0.23 12.0 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5540) zf-C3HC4_3 PF13920.6 EFX06523.1 - 2.1 8.2 10.1 2 8.3 7.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) XPA_N PF01286.18 EFX06523.1 - 2.3 8.3 12.1 0.24 11.5 7.3 1.9 2 0 0 2 2 2 0 XPA protein N-terminal DNA_binding_1 PF01035.20 EFX06524.1 - 6.7e-25 87.0 0.0 8.6e-25 86.7 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF4224 PF13986.6 EFX06524.1 - 0.0024 17.7 0.1 0.062 13.2 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4224) Steroid_dh PF02544.16 EFX06525.1 - 4.1e-21 75.5 0.9 1.2e-20 74.0 0.1 2.1 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EFX06525.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) PEMT PF04191.13 EFX06525.1 - 0.027 14.9 0.3 0.21 12.0 0.0 2.4 3 0 0 3 3 3 0 Phospholipid methyltransferase Asparaginase_2 PF01112.18 EFX06526.1 - 2.1e-37 128.8 8.7 4.7e-36 124.4 8.7 2.3 1 1 0 1 1 1 1 Asparaginase IncF PF17626.2 EFX06526.1 - 0.038 14.3 0.0 0.81 10.1 0.0 2.4 2 0 0 2 2 2 0 Inclusion membrane protein F Trp_syntA PF00290.20 EFX06527.1 - 3.6e-96 321.0 1.1 1.9e-95 318.6 0.1 2.1 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.25 EFX06527.1 - 3.4e-47 161.3 2.1 3.4e-47 161.3 2.1 2.3 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme HET PF06985.11 EFX06528.1 - 0.00051 20.4 0.7 0.021 15.1 0.0 2.7 3 0 0 3 3 3 2 Heterokaryon incompatibility protein (HET) Ferric_reduct PF01794.19 EFX06529.1 - 4.2e-28 98.0 6.8 4.2e-28 98.0 6.8 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EFX06529.1 - 9.1e-12 45.0 0.0 1.6e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EFX06529.1 - 1.8e-10 41.2 0.0 2.5e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EFX06529.1 - 0.0042 17.7 0.0 0.014 16.1 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain DUF1195 PF06708.11 EFX06529.1 - 1.2 8.9 5.1 10 5.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1195) Na_Ca_ex PF01699.24 EFX06530.1 - 7.9e-23 81.1 32.2 9.8e-14 51.6 14.6 4.2 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EFX06530.1 - 1.7e-16 60.6 10.5 1.7e-16 60.6 10.5 4.0 3 0 0 3 3 3 1 Inner membrane component domain GPI2 PF06432.11 EFX06530.1 - 0.008 15.7 0.5 0.26 10.7 0.0 2.9 2 1 0 2 2 2 1 Phosphatidylinositol N-acetylglucosaminyltransferase zf-CSL PF05207.13 EFX06532.1 - 5.6e-20 70.8 1.8 1.2e-19 69.8 0.2 2.2 2 0 0 2 2 2 1 CSL zinc finger Avl9 PF09794.9 EFX06532.1 - 0.17 10.6 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Transport protein Avl9 Gon7 PF08738.10 EFX06533.1 - 3.3e-10 40.0 0.6 1.5e-09 37.9 0.6 1.7 1 1 0 1 1 1 1 Gon7 family DUF3138 PF11336.8 EFX06533.1 - 0.12 11.0 4.4 0.14 10.7 4.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Kinesin PF00225.23 EFX06534.1 - 6e-88 295.0 0.2 2.5e-87 292.9 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFX06534.1 - 1.4e-16 60.8 0.0 1.4e-13 51.0 0.0 3.1 2 0 0 2 2 2 2 Microtubule binding THOC7 PF05615.13 EFX06534.1 - 3.3e-05 24.2 8.2 3.3e-05 24.2 8.2 10.0 9 2 2 11 11 11 4 Tho complex subunit 7 DUF812 PF05667.11 EFX06534.1 - 5.2e-05 22.4 10.3 5.2e-05 22.4 10.3 5.3 2 2 1 4 4 4 1 Protein of unknown function (DUF812) CENP-B_dimeris PF09026.10 EFX06534.1 - 0.16 12.4 4.3 0.54 10.7 4.3 2.0 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Fib_alpha PF08702.10 EFX06534.1 - 7.7 6.7 80.8 0.78 9.9 6.5 10.4 6 3 5 11 11 11 0 Fibrinogen alpha/beta chain family LicD PF04991.13 EFX06535.1 - 1.2e-21 77.9 4.1 4.4e-14 53.2 1.5 2.2 1 1 1 2 2 2 2 LicD family DUF1977 PF09320.11 EFX06536.1 - 3.1e-25 88.5 0.1 6.4e-25 87.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EFX06536.1 - 2e-19 69.4 0.1 3.1e-19 68.9 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Aldo_ket_red PF00248.21 EFX06537.1 - 1.3e-41 142.7 0.0 2.3e-39 135.4 0.0 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family SPO22 PF08631.10 EFX06538.1 - 0.00013 21.6 0.0 0.00027 20.5 0.0 1.4 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like DUF3099 PF11298.8 EFX06539.1 - 0.44 10.7 2.6 1.4 9.1 2.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) Metallophos PF00149.28 EFX06540.1 - 4.2e-32 112.3 0.0 9.8e-28 98.1 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EFX06540.1 - 0.042 13.5 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain TMEM51 PF15345.6 EFX06541.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 DUF2561 PF10812.8 EFX06541.1 - 9.6 6.2 9.9 3.3 7.7 3.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2561) adh_short_C2 PF13561.6 EFX06543.1 - 2.6e-54 184.3 6.4 3.6e-54 183.8 6.4 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX06543.1 - 1.4e-46 158.5 1.0 1.8e-46 158.1 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX06543.1 - 1.8e-07 31.2 2.8 6.6e-07 29.4 2.8 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFX06543.1 - 0.0089 15.5 0.1 0.027 13.9 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Aldo_ket_red PF00248.21 EFX06544.1 - 7.4e-74 248.6 0.0 8.4e-74 248.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_L28 PF00830.19 EFX06545.1 - 1.8e-17 63.2 1.8 2.7e-17 62.7 1.8 1.2 1 0 0 1 1 1 1 Ribosomal L28 family Pro-kuma_activ PF09286.11 EFX06546.1 - 4.8e-27 95.0 0.1 1.5e-25 90.2 0.1 2.4 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFX06546.1 - 0.00021 20.7 0.1 0.00048 19.5 0.1 1.5 1 0 0 1 1 1 1 Subtilase family Zn_ribbon_SprT PF17283.2 EFX06547.1 - 1.1 9.2 11.1 0.17 11.8 2.2 2.7 2 1 1 3 3 3 0 SprT-like zinc ribbon domain DUF2072 PF09845.9 EFX06547.1 - 2.5 8.4 11.3 17 5.7 11.3 2.1 1 1 0 1 1 1 0 Zn-ribbon containing protein AIF-MLS PF14962.6 EFX06547.1 - 5.4 6.9 7.1 8.6 6.3 7.1 1.2 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Glyco_hydro_16 PF00722.21 EFX06548.1 - 6.2e-41 139.8 4.8 6.2e-41 139.8 4.8 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 DUF3123 PF11321.8 EFX06548.1 - 0.18 12.5 2.3 0.33 11.6 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Alg14 PF08660.11 EFX06549.1 - 8.6e-44 149.5 0.2 1.9e-43 148.4 0.0 1.6 2 0 0 2 2 2 1 Oligosaccharide biosynthesis protein Alg14 like Kp4 PF09044.10 EFX06550.1 - 1.5e-32 112.3 2.7 1.9e-32 111.9 2.7 1.1 1 0 0 1 1 1 1 Kp4 MU117 PF15474.6 EFX06550.1 - 0.0031 18.3 2.7 0.0068 17.2 2.7 1.6 1 1 0 1 1 1 1 Meiotically up-regulated gene family SPOR PF05036.13 EFX06550.1 - 0.086 13.2 0.0 2.5 8.5 0.0 2.1 2 0 0 2 2 2 0 Sporulation related domain Ank_2 PF12796.7 EFX06551.1 - 3.1e-36 123.8 5.1 5.4e-11 42.9 0.0 4.6 2 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX06551.1 - 1e-29 102.5 18.3 7.1e-07 29.7 0.1 6.9 3 3 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06551.1 - 1.2e-29 99.0 9.7 0.0001 22.5 0.0 8.1 9 0 0 9 9 9 6 Ankyrin repeat Ank PF00023.30 EFX06551.1 - 1.2e-24 85.6 18.1 0.00042 20.6 0.0 7.7 7 1 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 EFX06551.1 - 6.4e-14 51.8 21.2 3.4e-05 24.0 0.3 6.0 4 2 2 6 6 6 3 Ankyrin repeats (many copies) FA PF08736.11 EFX06551.1 - 0.077 13.1 0.1 7.4 6.7 0.0 3.0 3 0 0 3 3 3 0 FERM adjacent (FA) Reductase_C PF14759.6 EFX06551.1 - 0.23 12.0 2.8 17 6.0 0.0 4.0 4 0 0 4 4 4 0 Reductase C-terminal DPBB_1 PF03330.18 EFX06552.1 - 3e-07 30.6 3.0 4e-07 30.2 0.1 2.8 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 EFX06552.1 - 3.6e-05 23.6 0.3 9.3e-05 22.3 0.1 1.9 2 0 0 2 2 2 1 Barwin family Pollen_allerg_1 PF01357.21 EFX06552.1 - 0.025 14.6 0.6 0.063 13.3 0.6 1.7 1 0 0 1 1 1 0 Pollen allergen tRNA_edit PF04073.15 EFX06552.1 - 0.05 13.7 1.2 0.091 12.8 1.2 1.5 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain BNR PF02012.20 EFX06552.1 - 0.13 12.4 0.8 0.4 10.9 0.8 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat LmjF365940-deam PF14421.6 EFX06553.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases MFS_1 PF07690.16 EFX06554.1 - 7.1e-38 130.4 49.0 7.1e-38 130.4 49.0 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EFX06554.1 - 1.6e-15 56.6 23.0 3e-15 55.7 22.9 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EFX06554.1 - 0.066 11.5 10.1 0.13 10.5 1.9 2.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family UNC45-central PF11701.8 EFX06555.1 - 4.7e-54 182.5 0.0 1.2e-53 181.2 0.0 1.7 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central HEAT_2 PF13646.6 EFX06555.1 - 1.8 9.0 22.2 2.3 8.7 2.7 5.9 3 1 3 6 6 6 0 HEAT repeats Aminotran_1_2 PF00155.21 EFX06556.1 - 2.4e-87 293.5 0.0 2.8e-87 293.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II zf-C2H2 PF00096.26 EFX06557.1 - 0.0015 18.9 26.5 0.0026 18.1 0.7 4.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFX06557.1 - 0.0042 17.4 0.4 0.0042 17.4 0.4 3.7 6 0 0 6 6 6 1 Zinc-finger double domain GATA PF00320.27 EFX06557.1 - 0.18 11.4 2.2 0.39 10.3 0.1 2.6 2 0 0 2 2 2 0 GATA zinc finger zf-CHCC PF10276.9 EFX06557.1 - 0.25 11.4 10.1 0.91 9.6 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger domain HypA PF01155.19 EFX06557.1 - 1.1 9.3 3.8 2.2 8.3 3.8 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_4 PF13894.6 EFX06557.1 - 2.3 9.3 27.6 0.12 13.3 1.1 5.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-BED PF02892.15 EFX06557.1 - 2.5 8.2 15.2 0.53 10.3 0.4 3.8 4 0 0 4 4 4 0 BED zinc finger PyrI_C PF02748.15 EFX06557.1 - 5.4 7.0 8.9 24 4.9 5.5 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain RhoGAP PF00620.27 EFX06558.1 - 1e-11 44.9 0.0 1.8e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Helo_like_N PF17111.5 EFX06558.1 - 0.016 14.5 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Methyltransf_23 PF13489.6 EFX06559.1 - 1.8e-15 57.2 0.0 3.5e-15 56.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFX06559.1 - 3.3e-11 43.7 0.0 6.1e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFX06559.1 - 7.7e-11 42.5 0.0 1.6e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFX06559.1 - 2.7e-08 34.4 0.0 1.4e-07 32.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFX06559.1 - 2.1e-05 24.3 0.0 0.00049 19.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFX06559.1 - 0.00018 21.0 0.0 0.00074 18.9 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFX06559.1 - 0.002 17.7 0.0 0.0096 15.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EFX06559.1 - 0.0064 16.6 0.0 0.016 15.3 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EFX06559.1 - 0.0085 15.6 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 EFX06559.1 - 0.053 13.3 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase FSA_C PF10479.9 EFX06559.1 - 3.1 5.8 4.4 4.6 5.2 4.4 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF4235 PF14019.6 EFX06560.1 - 0.014 15.5 8.5 1.1 9.4 0.0 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4235) 60KD_IMP PF02096.20 EFX06561.1 - 0.00018 21.5 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 60Kd inner membrane protein DUF4560 PF15118.6 EFX06561.1 - 0.037 13.9 0.0 0.097 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4560) DUF2824 PF11039.8 EFX06561.1 - 0.22 11.5 0.0 0.36 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2824) RTP1_C1 PF10363.9 EFX06563.1 - 4.9e-25 87.9 1.3 1.3e-23 83.3 0.1 3.2 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EFX06563.1 - 1.4e-13 50.2 1.3 3.7e-13 48.9 1.3 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT_2 PF13646.6 EFX06563.1 - 1.6 9.2 12.4 2.9 8.3 1.2 4.8 4 1 0 4 4 4 0 HEAT repeats Pox_Ag35 PF03286.14 EFX06563.1 - 3.4 7.4 6.7 0.29 10.9 0.7 2.2 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Tcf25 PF04910.14 EFX06564.1 - 9.6e-51 172.9 0.0 1.4e-50 172.4 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 DUF4746 PF15928.5 EFX06564.1 - 0.068 12.6 0.1 0.068 12.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Apt1 PF10351.9 EFX06564.1 - 2.6 6.8 5.4 4.8 5.9 5.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Guanylate_kin PF00625.21 EFX06565.1 - 2.2e-56 190.4 0.0 2.5e-56 190.3 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 EFX06565.1 - 4.5e-05 23.6 0.1 0.00014 22.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFX06565.1 - 0.00021 21.4 0.1 0.0012 19.0 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EFX06565.1 - 0.00024 20.9 0.2 0.62 9.7 0.2 2.4 1 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFX06565.1 - 0.00093 19.5 0.0 0.0021 18.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFX06565.1 - 0.0015 18.5 0.0 0.0043 17.0 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase DUF4914 PF16260.5 EFX06565.1 - 0.003 15.7 0.0 0.0038 15.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4914) AAA_16 PF13191.6 EFX06565.1 - 0.0047 17.3 0.0 0.0055 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFX06565.1 - 0.0072 16.9 0.2 0.037 14.6 0.2 2.1 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFX06565.1 - 0.017 15.0 0.5 0.23 11.3 0.5 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EFX06565.1 - 0.05 13.9 0.0 0.071 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 EFX06565.1 - 0.067 13.0 0.0 3 7.6 0.0 2.5 2 1 1 3 3 3 0 Deoxynucleoside kinase adh_short_C2 PF13561.6 EFX06566.1 - 5.1e-54 183.3 3.6 4.1e-52 177.1 3.6 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX06566.1 - 3.2e-46 157.3 1.9 3.8e-46 157.0 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFX06566.1 - 9.5e-14 51.7 0.9 1.7e-13 50.9 0.9 1.4 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFX06566.1 - 0.0043 17.0 0.4 0.0079 16.1 0.4 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CFEM PF05730.11 EFX06568.1 - 4.9e-13 49.0 7.6 9.1e-13 48.1 7.6 1.5 1 0 0 1 1 1 1 CFEM domain PRR20 PF15708.5 EFX06568.1 - 0.19 11.6 0.1 0.3 10.9 0.1 1.2 1 0 0 1 1 1 0 Proline-rich protein family 20 Ribosomal_S7 PF00177.21 EFX06569.1 - 9.3e-37 126.0 1.8 1.2e-36 125.6 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Rav1p_C PF12234.8 EFX06570.1 - 5.7e-281 933.5 0.3 7.7e-281 933.1 0.3 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal WD40 PF00400.32 EFX06570.1 - 0.059 14.3 7.9 7.7 7.6 0.2 5.7 5 0 0 5 5 5 0 WD domain, G-beta repeat G0-G1_switch_2 PF15103.6 EFX06570.1 - 0.2 12.1 0.0 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 Methyltransf_31 PF13847.6 EFX06571.1 - 0.033 14.0 0.1 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain NB-ARC PF00931.22 EFX06572.1 - 3.7e-13 49.2 0.0 5.7e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EFX06572.1 - 1.6e-07 31.9 0.0 3.7e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain TPR_12 PF13424.6 EFX06572.1 - 3.7e-07 30.3 1.0 4e-05 23.8 0.3 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat ATPase_2 PF01637.18 EFX06572.1 - 0.00016 21.7 0.0 0.0014 18.6 0.0 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea TPR_7 PF13176.6 EFX06572.1 - 0.00023 20.9 0.7 7 6.9 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFX06572.1 - 0.00059 19.6 0.5 4.4 7.3 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat AAA_22 PF13401.6 EFX06572.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TPR_8 PF13181.6 EFX06572.1 - 5.2 7.5 4.9 44 4.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Chromo PF00385.24 EFX06573.1 - 2.5e-09 36.9 0.6 5.3e-09 35.9 0.6 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SUIM_assoc PF16619.5 EFX06573.1 - 0.21 11.7 5.0 0.57 10.3 1.3 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Phostensin_N PF13916.6 EFX06573.1 - 0.39 11.1 4.0 0.78 10.1 0.3 3.0 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Tnp_P_element_C PF12596.8 EFX06574.1 - 2.9e-05 24.5 29.0 75 3.9 0.4 11.5 1 1 10 11 11 11 0 87kDa Transposase Alpha_E2_glycop PF00943.19 EFX06574.1 - 3.5e-05 22.7 23.3 4 6.1 0.1 9.3 1 1 8 10 10 10 8 Alphavirus E2 glycoprotein DUF1523 PF07509.11 EFX06574.1 - 0.066 12.6 7.0 4.3 6.7 0.2 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF1523) ATS3 PF06232.11 EFX06575.1 - 0.12 12.3 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Embryo-specific protein 3, (ATS3) DEAD PF00270.29 EFX06576.1 - 2.7e-33 115.2 0.0 1.9e-15 57.1 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX06576.1 - 2.2e-21 76.3 0.0 6.1e-21 74.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX06576.1 - 9.5e-05 22.5 3.4 0.00037 20.5 0.0 3.2 2 2 0 2 2 2 1 Type III restriction enzyme, res subunit Tcp11 PF05794.13 EFX06577.1 - 8.8e-92 308.5 0.1 8.8e-92 308.5 0.1 2.1 3 0 0 3 3 3 1 T-complex protein 11 PBP1_TM PF14812.6 EFX06578.1 - 0.022 15.1 1.5 0.05 14.0 1.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TT_ORF2 PF02957.15 EFX06578.1 - 0.084 13.8 0.7 0.2 12.6 0.1 1.9 2 0 0 2 2 2 0 TT viral ORF2 DEAD PF00270.29 EFX06579.1 - 1.4e-40 139.0 0.1 5.8e-40 136.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFX06579.1 - 5.7e-18 65.3 0.0 1.6e-16 60.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFX06579.1 - 5e-07 29.9 0.0 8.1e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EFX06579.1 - 0.0025 17.6 0.2 0.007 16.1 0.2 1.8 1 0 0 1 1 1 1 AAA domain Fungal_trans PF04082.18 EFX06580.1 - 9.7e-26 90.4 0.0 1.9e-25 89.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EFX06580.1 - 2.6e-07 30.6 13.5 6e-07 29.5 13.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NYD-SP28_assoc PF14775.6 EFX06580.1 - 0.19 11.9 1.5 0.49 10.5 1.5 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain PRKG1_interact PF15898.5 EFX06580.1 - 1.6 9.6 5.9 4.2 8.3 5.9 1.7 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Zn_clus PF00172.18 EFX06581.1 - 0.0034 17.5 8.1 0.015 15.4 8.1 2.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CHCC PF10276.9 EFX06581.1 - 0.11 12.6 2.8 2 8.5 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger domain ATAD4 PF15321.6 EFX06581.1 - 0.39 12.1 1.4 1.7 10.1 0.2 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Spt20 PF12090.8 EFX06581.1 - 6.9 6.2 9.7 0.081 12.5 1.9 1.7 2 0 0 2 2 2 0 Spt20 family adh_short_C2 PF13561.6 EFX06582.1 - 9.5e-43 146.4 1.3 4.5e-38 131.1 0.5 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFX06582.1 - 8.7e-38 129.7 0.2 2.4e-28 98.9 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EFX06582.1 - 9.6e-05 22.4 1.3 0.0006 19.8 1.2 2.1 1 1 0 1 1 1 1 KR domain MFS_1 PF07690.16 EFX06583.1 - 7.2e-37 127.1 41.2 2.6e-36 125.3 41.2 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFX06583.1 - 7.7e-09 34.9 14.4 7.7e-09 34.9 14.4 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter DnaJ PF00226.31 EFX06584.1 - 0.00016 21.7 0.0 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain TRI9 PF08195.11 EFX06585.1 - 0.24 11.3 6.2 0.33 10.9 6.2 1.2 1 0 0 1 1 1 0 TRI9 protein Fungal_trans PF04082.18 EFX06586.1 - 0.00054 19.1 0.0 0.00094 18.3 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain PAPA-1 PF04795.12 EFX06587.1 - 4.7e-28 97.8 3.8 4.7e-28 97.8 3.8 2.0 2 0 0 2 2 2 1 PAPA-1-like conserved region GMC_oxred_N PF00732.19 EFX06588.1 - 8.3e-26 91.0 0.0 1.2e-23 83.9 0.1 3.0 2 1 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX06588.1 - 5.3e-24 85.4 0.0 9.1e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EFX06588.1 - 0.00014 21.2 0.0 0.00065 19.0 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX06588.1 - 0.014 14.5 0.1 0.16 11.0 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EFX06588.1 - 0.022 14.0 0.0 3.1 7.0 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HHH PF00633.23 EFX06588.1 - 0.03 14.2 0.1 3.2 7.8 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif NAD_binding_8 PF13450.6 EFX06588.1 - 0.038 14.2 0.3 0.038 14.2 0.3 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFX06588.1 - 0.21 10.3 0.1 0.3 9.7 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.16 EFX06589.1 - 2.1e-31 109.1 32.3 2.1e-31 109.1 32.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Actin PF00022.19 EFX06591.1 - 4.1e-86 289.1 0.0 4.8e-53 180.2 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFX06591.1 - 0.033 13.0 0.0 1.9 7.2 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein AcetylCoA_hydro PF02550.15 EFX06592.1 - 7e-49 166.5 0.0 1e-48 165.9 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EFX06592.1 - 8.2e-41 139.5 0.0 1.2e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain DUF1995 PF09353.10 EFX06593.1 - 0.071 13.1 0.0 0.091 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1995) PRK PF00485.18 EFX06595.1 - 0.00011 22.0 0.0 0.0027 17.5 0.0 2.4 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 EFX06595.1 - 0.00029 20.7 0.1 0.001 19.0 0.0 1.9 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.6 EFX06595.1 - 0.0021 18.3 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFX06595.1 - 0.013 16.0 0.0 0.052 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EFX06595.1 - 0.059 13.2 0.0 0.98 9.2 0.0 2.5 3 0 0 3 3 3 0 Deoxynucleoside kinase G-alpha PF00503.20 EFX06595.1 - 0.28 10.3 0.0 0.37 9.9 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA PF00004.29 EFX06596.1 - 3e-16 60.0 0.0 5.7e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EFX06596.1 - 1.3e-15 57.5 0.0 3.9e-15 56.0 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFX06596.1 - 1.9e-12 47.3 0.0 7.6e-12 45.3 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_30 PF13604.6 EFX06596.1 - 8.4e-08 32.2 0.0 2.4e-07 30.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EFX06596.1 - 1.1e-07 32.0 0.0 2.5e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 EFX06596.1 - 1.1e-06 28.5 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFX06596.1 - 2.1e-06 28.3 0.1 1.3e-05 25.7 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_assoc_2 PF16193.5 EFX06596.1 - 3.5e-06 27.2 0.3 1.1e-05 25.7 0.1 1.9 2 0 0 2 2 1 1 AAA C-terminal domain AAA_11 PF13086.6 EFX06596.1 - 1.1e-05 25.4 0.1 6.1e-05 22.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFX06596.1 - 1.3e-05 25.4 0.1 0.00013 22.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFX06596.1 - 2.6e-05 24.2 0.1 0.0002 21.4 0.1 2.6 2 1 1 3 3 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFX06596.1 - 5.1e-05 23.3 0.0 0.00037 20.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.11 EFX06596.1 - 5.4e-05 23.1 0.0 0.00051 19.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EFX06596.1 - 5.4e-05 22.5 0.0 8.6e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DNA_pol3_delta PF06144.13 EFX06596.1 - 9.5e-05 22.2 0.0 0.00016 21.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 EFX06596.1 - 0.00018 21.3 0.0 0.00082 19.1 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EFX06596.1 - 0.00056 20.3 0.1 0.0027 18.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFX06596.1 - 0.0031 17.8 0.1 0.01 16.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFX06596.1 - 0.0046 16.3 0.1 0.084 12.2 0.0 2.5 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 EFX06596.1 - 0.0064 15.9 0.0 0.039 13.3 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein ResIII PF04851.15 EFX06596.1 - 0.0066 16.5 0.0 0.049 13.6 0.0 2.0 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFX06596.1 - 0.011 15.5 0.1 0.075 12.8 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase PhoH PF02562.16 EFX06596.1 - 0.012 15.1 0.0 1.5 8.2 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.6 EFX06596.1 - 0.013 16.1 0.0 0.023 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFX06596.1 - 0.03 13.9 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EFX06596.1 - 0.042 13.4 0.0 0.13 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EFX06596.1 - 0.042 13.1 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 EFX06596.1 - 0.086 12.5 0.0 0.42 10.3 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EFX06596.1 - 0.086 13.2 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EFX06596.1 - 0.097 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea FMO-like PF00743.19 EFX06597.1 - 1.1e-11 43.9 0.1 1.1e-10 40.6 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EFX06597.1 - 4.8e-10 39.5 0.1 1.5e-09 37.9 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX06597.1 - 1.1e-09 38.0 0.0 4.8e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX06597.1 - 1.4e-08 34.3 0.0 4.2e-07 29.4 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFX06597.1 - 1.8e-07 30.7 0.7 1.9e-06 27.4 0.8 2.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFX06597.1 - 3.5e-06 26.8 3.0 0.0039 16.8 0.1 3.2 2 1 1 3 3 3 2 FAD dependent oxidoreductase Mqo PF06039.15 EFX06597.1 - 0.0012 17.5 0.5 0.23 10.0 0.0 2.5 3 0 0 3 3 3 2 Malate:quinone oxidoreductase (Mqo) NAD_binding_9 PF13454.6 EFX06597.1 - 0.0028 17.6 2.7 0.41 10.6 0.3 3.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EFX06597.1 - 0.0029 16.9 0.1 0.012 14.9 0.0 1.9 2 0 0 2 2 2 1 Thi4 family RRM_1 PF00076.22 EFX06598.1 - 1.4e-15 56.9 0.0 7e-08 32.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFX06598.1 - 0.00031 20.8 0.0 0.00043 20.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 EFX06598.1 - 0.12 12.3 0.0 1.5 8.7 0.0 2.0 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ras PF00071.22 EFX06599.1 - 2.7e-63 212.4 0.2 3.1e-63 212.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFX06599.1 - 2.7e-35 121.2 0.2 3.9e-35 120.7 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFX06599.1 - 4.6e-13 49.0 0.1 5.9e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFX06599.1 - 7.9e-08 32.4 0.1 1.2e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFX06599.1 - 0.00034 20.2 0.1 0.0017 17.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFX06599.1 - 0.00043 19.7 0.1 0.00063 19.2 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFX06599.1 - 0.00055 19.9 0.9 0.017 15.0 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFX06599.1 - 0.0029 17.9 0.0 0.019 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EFX06599.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EFX06599.1 - 0.017 15.1 0.1 0.046 13.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFX06599.1 - 0.018 15.4 0.1 0.031 14.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFX06599.1 - 0.022 15.3 0.1 0.03 14.8 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EFX06599.1 - 0.029 14.1 0.1 0.063 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFX06599.1 - 0.032 13.6 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA_21 PF13304.6 EFX06599.1 - 0.093 12.5 0.5 0.14 12.0 0.5 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SpoIIID PF12116.8 EFX06599.1 - 0.097 12.8 0.1 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D FeoB_N PF02421.18 EFX06599.1 - 0.1 12.1 0.0 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_7 PF12775.7 EFX06599.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF953 PF06110.11 EFX06600.1 - 1.6e-15 56.7 0.0 2e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 EFX06600.1 - 0.002 18.1 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EFX06600.1 - 0.036 13.8 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Aldo_ket_red PF00248.21 EFX06601.1 - 2.6e-69 233.7 0.0 2.9e-69 233.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TetR_C_12 PF16914.5 EFX06601.1 - 0.092 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional repressor C-terminal Amidoligase_2 PF12224.8 EFX06603.1 - 6e-12 45.8 0.0 1.1e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 Putative amidoligase enzyme B12D PF06522.11 EFX06604.1 - 1.3e-05 24.9 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit DSPc PF00782.20 EFX06605.1 - 2.2e-08 34.0 0.0 0.00067 19.5 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Clathrin PF00637.20 EFX06606.1 - 3.8e-21 75.5 1.3 5.2e-20 71.8 0.3 3.0 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.8 EFX06606.1 - 6.2e-19 68.0 0.1 1.6e-18 66.6 0.1 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal HATPase_c_3 PF13589.6 EFX06606.1 - 4.1e-13 49.3 0.0 8.2e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-C3H2C3 PF17122.5 EFX06606.1 - 3.1e-06 27.1 2.7 3.1e-06 27.1 2.7 2.2 2 0 0 2 2 2 1 Zinc-finger zf-RING_5 PF14634.6 EFX06606.1 - 5e-05 23.2 0.5 9.5e-05 22.3 0.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain MutL_C PF08676.11 EFX06606.1 - 0.00088 19.1 0.3 0.0038 17.0 0.1 2.2 2 1 0 2 2 2 1 MutL C terminal dimerisation domain TPR_11 PF13414.6 EFX06606.1 - 0.015 15.0 1.9 0.02 14.6 0.2 2.1 2 0 0 2 2 2 0 TPR repeat zf-RING_2 PF13639.6 EFX06606.1 - 0.03 14.7 1.3 0.082 13.3 1.3 1.8 1 0 0 1 1 1 0 Ring finger domain HATPase_c PF02518.26 EFX06606.1 - 0.038 14.5 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-RING_UBOX PF13445.6 EFX06606.1 - 0.057 13.5 1.2 0.14 12.2 1.2 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EFX06606.1 - 0.11 12.4 0.3 0.24 11.3 0.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFX06606.1 - 0.14 12.2 0.9 0.39 10.8 0.9 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EFX06606.1 - 0.16 11.8 9.0 0.89 9.4 9.0 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFX06606.1 - 0.4 11.0 3.9 1.1 9.6 3.9 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain TPR_14 PF13428.6 EFX06606.1 - 2.5 9.2 11.2 22 6.2 0.0 4.7 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 EFX06608.1 - 2.6e-13 50.1 0.0 0.059 13.7 0.0 4.3 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L32p PF01783.23 EFX06608.1 - 6.3e-12 45.6 6.5 1.5e-11 44.4 6.5 1.6 1 0 0 1 1 1 1 Ribosomal L32p protein family WD40 PF00400.32 EFX06608.1 - 4.3e-08 33.7 12.5 0.0013 19.5 0.2 6.2 6 1 0 6 6 6 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EFX06608.1 - 5.6e-05 21.8 0.0 0.00032 19.4 0.1 1.9 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 EFX06608.1 - 0.00057 18.7 0.1 0.0073 15.0 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Hira PF07569.11 EFX06608.1 - 0.068 12.9 0.1 6.6 6.4 0.0 2.3 2 0 0 2 2 2 0 TUP1-like enhancer of split Nbas_N PF15492.6 EFX06608.1 - 0.081 12.2 0.5 0.42 9.9 0.1 2.4 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 EFX06608.1 - 0.24 10.4 0.0 0.39 9.7 0.0 1.2 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain AAA PF00004.29 EFX06609.1 - 1.5e-34 119.3 0.0 5.1e-34 117.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX06609.1 - 1.2e-11 44.2 0.0 2.7e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EFX06609.1 - 4e-10 40.3 0.7 9.1e-07 29.4 0.0 3.3 3 2 1 4 4 3 1 AAA ATPase domain DUF815 PF05673.13 EFX06609.1 - 2.3e-05 23.7 0.0 3.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFX06609.1 - 2.4e-05 24.6 0.3 0.0074 16.6 0.0 3.1 3 1 1 4 4 3 1 AAA domain AAA_14 PF13173.6 EFX06609.1 - 7.9e-05 22.7 0.0 0.00043 20.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFX06609.1 - 0.00016 21.9 0.0 0.00029 21.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFX06609.1 - 0.00018 21.5 0.1 0.00079 19.4 0.1 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFX06609.1 - 0.00032 20.5 0.0 0.00056 19.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFX06609.1 - 0.00035 20.9 0.0 0.00081 19.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EFX06609.1 - 0.002 18.7 0.0 0.004 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFX06609.1 - 0.0025 18.1 0.0 0.0098 16.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EFX06609.1 - 0.0029 17.6 0.0 0.095 12.6 0.0 2.2 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EFX06609.1 - 0.0046 16.7 0.0 0.012 15.3 0.0 1.6 2 0 0 2 2 2 1 IstB-like ATP binding protein TsaE PF02367.17 EFX06609.1 - 0.0056 16.7 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 EFX06609.1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFX06609.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EFX06609.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EFX06609.1 - 0.03 13.9 0.0 0.067 12.7 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_2 PF07724.14 EFX06609.1 - 0.046 13.8 0.0 0.32 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 EFX06609.1 - 0.07 12.4 0.1 0.13 11.5 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 EFX06609.1 - 0.071 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFX06609.1 - 0.079 13.3 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EFX06609.1 - 0.085 12.3 0.0 0.25 10.7 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein NACHT PF05729.12 EFX06609.1 - 0.09 12.7 0.0 0.26 11.2 0.0 1.7 2 0 0 2 2 1 0 NACHT domain AAA_3 PF07726.11 EFX06609.1 - 0.1 12.4 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFX06609.1 - 0.11 11.9 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF853 PF05872.12 EFX06609.1 - 0.11 11.0 0.0 9.5 4.7 0.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) AAA_25 PF13481.6 EFX06609.1 - 0.13 11.8 0.0 1.9 8.0 0.1 2.6 4 0 0 4 4 3 0 AAA domain Bac_DnaA PF00308.18 EFX06609.1 - 0.13 12.0 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 EFX06609.1 - 0.2 10.7 0.0 0.32 10.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DIOX_N PF14226.6 EFX06610.1 - 8.1e-25 87.9 0.3 8.1e-25 87.9 0.3 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFX06610.1 - 4.8e-09 36.6 0.0 1.1e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3045 PF11243.8 EFX06610.1 - 0.075 13.2 0.1 3.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3045) Tfb4 PF03850.14 EFX06611.1 - 9e-85 284.5 0.0 1.2e-84 284.1 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 ALS_ss_C PF10369.9 EFX06612.1 - 5.7e-15 55.3 0.0 7.7e-14 51.7 0.0 2.6 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 EFX06612.1 - 8.2e-15 54.3 0.2 1.6e-14 53.3 0.2 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EFX06612.1 - 9.4e-08 31.8 0.0 1.9e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EFX06612.1 - 0.089 12.8 0.0 23 5.0 0.0 2.7 2 0 0 2 2 2 0 ACT domain Arb2 PF09757.9 EFX06614.1 - 1.3e-97 325.9 0.1 2e-97 325.4 0.1 1.3 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 EFX06614.1 - 2.1e-78 263.9 0.0 3.3e-78 263.3 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Brix PF04427.18 EFX06614.1 - 4.6e-40 137.8 0.0 8.5e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 Brix domain ATP-synt PF00231.19 EFX06614.1 - 0.08 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 ATP synthase Asp PF00026.23 EFX06615.1 - 6.5e-61 206.5 0.0 7.9e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFX06615.1 - 1.7e-07 31.7 3.0 0.00075 19.8 0.0 2.9 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EFX06615.1 - 0.033 14.0 0.0 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EFX06615.1 - 0.16 12.6 0.3 10 6.9 0.1 3.1 2 1 0 2 2 2 0 Aspartyl protease Aldedh PF00171.22 EFX06616.1 - 4.3e-123 411.2 0.0 1.7e-61 208.2 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family GATase_6 PF13522.6 EFX06617.1 - 6.7e-17 62.0 0.0 1.2e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EFX06617.1 - 2.6e-14 53.2 0.0 6.2e-14 52.0 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EFX06617.1 - 1.4e-05 24.6 0.1 2.7e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EFX06617.1 - 3.4e-05 22.9 0.0 5.7e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Aminotran_1_2 PF00155.21 EFX06618.1 - 2.4e-64 217.8 0.0 2.8e-64 217.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EFX06618.1 - 0.00023 20.6 0.0 0.00057 19.3 0.0 1.6 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EFX06618.1 - 0.0016 17.0 0.0 0.006 15.2 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EFX06618.1 - 0.013 14.8 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.19 EFX06618.1 - 0.062 12.3 0.0 0.3 10.0 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class-V FPP PF05911.11 EFX06619.1 - 2e-06 26.3 15.7 2e-06 26.3 15.7 1.7 2 0 0 2 2 2 1 Filament-like plant protein, long coiled-coil CALCOCO1 PF07888.11 EFX06619.1 - 4e-05 22.7 26.3 0.024 13.5 14.1 2.2 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like CdvA PF18822.1 EFX06619.1 - 0.00049 19.9 7.3 0.00049 19.9 7.3 2.8 3 0 0 3 3 3 1 CdvA-like coiled-coil domain Golgin_A5 PF09787.9 EFX06619.1 - 0.00054 19.5 21.1 0.00054 19.5 21.1 1.9 2 0 0 2 2 2 1 Golgin subfamily A member 5 Jnk-SapK_ap_N PF09744.9 EFX06619.1 - 0.00072 19.8 30.8 0.058 13.6 9.8 2.7 2 1 1 3 3 2 2 JNK_SAPK-associated protein-1 FAM184 PF15665.5 EFX06619.1 - 0.00088 19.1 21.1 0.0016 18.3 21.1 1.3 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B ATG16 PF08614.11 EFX06619.1 - 0.0017 18.6 38.2 0.0069 16.6 19.8 3.2 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) Cortex-I_coil PF09304.10 EFX06619.1 - 0.002 18.3 3.0 0.002 18.3 3.0 3.3 1 1 2 3 3 3 1 Cortexillin I, coiled coil Tropomyosin PF00261.20 EFX06619.1 - 0.002 17.6 25.7 0.002 17.6 25.7 1.9 2 0 0 2 2 2 1 Tropomyosin Myosin_tail_1 PF01576.19 EFX06619.1 - 0.0027 15.6 22.2 0.0048 14.8 22.2 1.3 1 0 0 1 1 1 1 Myosin tail DUF3584 PF12128.8 EFX06619.1 - 0.0039 14.8 22.3 0.0069 14.0 22.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) BLOC1_2 PF10046.9 EFX06619.1 - 0.0077 16.5 15.3 0.66 10.3 1.9 2.9 1 1 1 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 EFX06619.1 - 0.01 16.0 32.0 0.01 16.0 32.0 2.4 2 1 0 2 2 1 1 Tropomyosin like BST2 PF16716.5 EFX06619.1 - 0.018 15.6 28.4 0.026 15.1 1.7 3.9 2 1 2 4 4 4 0 Bone marrow stromal antigen 2 AAA_32 PF13654.6 EFX06619.1 - 0.045 12.5 12.6 0.064 12.0 12.6 1.2 1 0 0 1 1 1 0 AAA domain Flg_hook PF02120.16 EFX06619.1 - 0.052 13.4 2.4 9.7 6.2 0.0 2.8 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK BCAS2 PF05700.11 EFX06619.1 - 0.06 13.0 19.0 0.11 12.1 5.5 2.3 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) EzrA PF06160.12 EFX06619.1 - 0.12 10.5 15.5 0.19 9.8 15.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ABC_tran_CTD PF16326.5 EFX06619.1 - 0.13 12.5 25.7 1.3 9.3 10.8 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 EFX06619.1 - 0.27 11.2 8.4 0.75 9.8 1.7 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoO PF09769.9 EFX06619.1 - 0.31 11.0 7.1 2.8 7.9 1.2 2.9 1 1 2 3 3 3 0 Apolipoprotein O PspA_IM30 PF04012.12 EFX06619.1 - 0.32 10.6 27.4 7.7 6.0 20.8 2.3 1 1 0 1 1 1 0 PspA/IM30 family Prominin PF05478.11 EFX06619.1 - 0.39 8.6 4.0 0.61 8.0 4.0 1.4 1 0 0 1 1 1 0 Prominin APG6_N PF17675.1 EFX06619.1 - 0.4 11.2 38.6 0.036 14.6 14.3 2.5 2 1 1 3 3 2 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 EFX06619.1 - 0.41 10.7 32.8 0.11 12.5 12.2 2.5 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tektin PF03148.14 EFX06619.1 - 0.41 9.3 23.3 0.074 11.8 6.5 3.2 1 1 2 3 3 3 0 Tektin family SOGA PF11365.8 EFX06619.1 - 0.43 11.7 15.9 0.63 11.2 11.4 2.8 3 0 0 3 3 2 0 Protein SOGA SecD-TM1 PF13721.6 EFX06619.1 - 0.44 11.0 2.7 1 9.9 2.7 1.6 1 0 0 1 1 1 0 SecD export protein N-terminal TM region Nsp1_C PF05064.13 EFX06619.1 - 0.5 10.2 14.5 0.16 11.8 10.3 2.2 1 1 1 2 2 2 0 Nsp1-like C-terminal region TPR_MLP1_2 PF07926.12 EFX06619.1 - 0.55 10.3 37.6 1.6 8.8 8.5 3.9 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein YscO PF07321.12 EFX06619.1 - 0.74 9.8 30.8 4.5 7.2 6.8 3.2 1 1 2 3 3 3 0 Type III secretion protein YscO bZIP_2 PF07716.15 EFX06619.1 - 1 9.5 18.3 4.2 7.5 1.1 3.9 1 1 1 3 3 3 0 Basic region leucine zipper DUF4164 PF13747.6 EFX06619.1 - 1 9.7 25.9 0.23 11.8 3.8 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4164) DUF812 PF05667.11 EFX06619.1 - 1.1 8.1 27.5 0.0072 15.3 17.5 2.2 2 1 0 2 2 1 0 Protein of unknown function (DUF812) SesA PF17107.5 EFX06619.1 - 1.1 9.4 9.7 2 8.6 9.7 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Tup_N PF08581.10 EFX06619.1 - 1.3 9.4 17.2 1.3 9.4 3.9 3.1 2 1 1 3 3 3 0 Tup N-terminal CLZ PF16526.5 EFX06619.1 - 1.7 9.1 20.1 4.7 7.6 4.3 3.6 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.12 EFX06619.1 - 1.7 8.6 21.6 0.02 14.9 9.0 2.7 2 1 0 3 3 2 0 Laminin Domain II FUSC PF04632.12 EFX06619.1 - 1.9 6.9 7.6 3.1 6.2 7.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family FlaC_arch PF05377.11 EFX06619.1 - 2.1 8.8 16.1 0.6 10.5 1.7 3.5 4 0 0 4 4 3 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.20 EFX06619.1 - 2.1 8.3 29.3 0.31 11.0 2.6 3.6 2 1 2 4 4 4 0 Prefoldin subunit Vac_Fusion PF02346.16 EFX06619.1 - 2.2 7.9 5.4 7.9 6.2 0.6 2.8 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Filament PF00038.21 EFX06619.1 - 2.2 7.8 27.7 0.29 10.7 17.3 2.4 2 1 1 3 3 2 0 Intermediate filament protein CorA PF01544.18 EFX06619.1 - 2.3 7.4 8.9 3.5 6.9 8.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF148 PF02520.17 EFX06619.1 - 2.4 8.3 16.7 8 6.6 1.2 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF148 FH2 PF02181.23 EFX06619.1 - 3 6.9 15.2 8.2 5.4 14.4 2.0 1 1 0 1 1 1 0 Formin Homology 2 Domain AAA_13 PF13166.6 EFX06619.1 - 3 6.4 24.9 0.057 12.1 7.3 2.3 2 1 1 3 3 2 0 AAA domain IZUMO PF15005.6 EFX06619.1 - 3.2 8.3 7.9 5.6 7.5 7.9 1.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Fez1 PF06818.15 EFX06619.1 - 3.6 8.0 28.9 20 5.6 28.9 2.0 1 1 0 1 1 1 0 Fez1 Exonuc_VII_L PF02601.15 EFX06619.1 - 4.1 6.9 19.1 11 5.4 19.1 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 EFX06619.1 - 5 7.5 28.4 13 6.1 8.5 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) NPV_P10 PF05531.12 EFX06619.1 - 5.2 7.6 11.2 17 5.9 5.6 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fmp27_WPPW PF10359.9 EFX06619.1 - 5.2 5.8 21.9 5.1 5.8 10.6 2.3 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain CENP-Q PF13094.6 EFX06619.1 - 5.4 7.2 27.9 0.49 10.6 22.1 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Seryl_tRNA_N PF02403.22 EFX06619.1 - 6.2 7.1 29.7 6.3 7.1 7.6 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 EFX06619.1 - 6.4 6.0 28.2 0.24 10.7 8.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EFX06619.1 - 6.5 6.9 19.0 0.89 9.7 13.0 2.2 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family Noelin-1 PF12308.8 EFX06619.1 - 6.7 6.8 7.9 2.5 8.2 3.6 2.3 1 1 1 2 2 2 0 Neurogenesis glycoprotein Rootletin PF15035.6 EFX06619.1 - 7 6.6 23.8 4.8 7.2 4.8 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Uso1_p115_C PF04871.13 EFX06619.1 - 7.1 7.0 37.8 1.5 9.2 11.9 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region HrpB7 PF09486.10 EFX06619.1 - 7.7 6.9 23.2 5.8 7.3 6.0 2.5 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) YlqD PF11068.8 EFX06619.1 - 8.7 6.7 24.8 2.8 8.3 16.7 2.6 2 1 1 3 3 2 0 YlqD protein zf-TRAF PF02176.18 EFX06620.1 - 6.4e-10 39.6 24.1 9.2e-08 32.7 6.1 3.7 1 1 2 3 3 3 3 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 EFX06620.1 - 4e-08 33.0 7.4 4e-08 33.0 7.4 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFX06620.1 - 6.9e-07 29.0 6.5 6.9e-07 29.0 6.5 4.1 3 1 2 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFX06620.1 - 1.4e-06 28.5 5.3 1.4e-06 28.5 5.3 4.0 3 1 1 4 4 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EFX06620.1 - 2.4e-06 27.4 3.3 2.4e-06 27.4 3.3 3.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFX06620.1 - 8.7e-06 25.5 3.4 8.7e-06 25.5 3.4 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFX06620.1 - 0.00045 20.1 3.9 0.00045 20.1 3.9 3.2 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFX06620.1 - 0.0038 17.1 4.7 0.0038 17.1 4.7 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFX06620.1 - 0.0088 16.3 4.3 0.0088 16.3 4.3 3.5 3 2 0 3 3 3 1 RING-H2 zinc finger domain RdRP_2 PF00978.21 EFX06620.1 - 0.029 13.3 0.1 0.052 12.4 0.1 1.3 1 0 0 1 1 1 0 RNA dependent RNA polymerase zf-P11 PF03854.14 EFX06620.1 - 0.033 13.8 0.5 0.033 13.8 0.5 3.1 2 1 1 3 3 3 0 P-11 zinc finger zf-C3HC4_4 PF15227.6 EFX06620.1 - 0.19 11.9 15.3 0.082 13.1 6.4 3.0 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Sgf11 PF08209.11 EFX06620.1 - 0.37 10.4 4.2 11 5.7 0.0 3.3 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) Mito_carr PF00153.27 EFX06621.1 - 1.4e-43 146.7 8.1 1.6e-15 56.8 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3533 PF12051.8 EFX06623.1 - 4.1e-20 72.0 4.0 5.1e-20 71.7 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Y_phosphatase PF00102.27 EFX06625.1 - 6.6e-58 196.1 0.0 3.2e-31 108.7 0.0 3.4 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Rhodanese PF00581.20 EFX06625.1 - 6e-12 46.0 0.0 2.2e-11 44.2 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EFX06625.1 - 0.064 13.1 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFX06625.1 - 0.065 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Cyto_heme_lyase PF01265.17 EFX06626.1 - 2.2e-37 129.2 15.2 1.2e-36 126.8 0.7 3.5 1 1 0 2 2 2 2 Cytochrome c/c1 heme lyase DUF5427 PF10310.9 EFX06626.1 - 2 7.3 5.4 2.6 6.9 5.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) MFS_1 PF07690.16 EFX06627.1 - 4.2e-14 52.2 8.4 4.2e-14 52.2 8.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EFX06627.1 - 0.00028 20.5 12.0 0.0025 17.3 0.7 3.4 3 1 0 3 3 3 2 Nodulin-like Hydrolase_4 PF12146.8 EFX06628.1 - 0.0003 20.1 0.0 0.00038 19.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EFX06628.1 - 0.0028 17.2 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EFX06628.1 - 0.0047 17.5 0.0 0.005 17.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.8 EFX06628.1 - 0.029 13.9 0.0 0.037 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Ser_hydrolase PF06821.13 EFX06628.1 - 0.2 11.5 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase Cutinase PF01083.22 EFX06628.1 - 0.21 11.5 0.0 2.2 8.2 0.0 2.0 1 1 0 2 2 2 0 Cutinase Glyco_hydro_43 PF04616.14 EFX06629.1 - 2e-38 132.4 1.3 3.1e-38 131.7 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 MAP65_ASE1 PF03999.12 EFX06630.1 - 0.73 8.5 10.7 0.86 8.2 10.7 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Apt1 PF10351.9 EFX06630.1 - 2.7 6.8 10.3 2.6 6.8 10.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EFX06630.1 - 8.3 5.1 7.9 9.9 4.8 7.9 1.1 1 0 0 1 1 1 0 Presenilin 2-Hacid_dh_C PF02826.19 EFX06631.1 - 4.3e-45 153.3 0.0 5.8e-45 152.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX06631.1 - 0.0017 18.0 0.0 0.0036 17.0 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EFX06631.1 - 0.01 16.4 0.2 0.11 13.0 0.1 2.2 2 0 0 2 2 2 1 XdhC Rossmann domain NAD_binding_7 PF13241.6 EFX06631.1 - 0.032 14.7 0.1 0.09 13.2 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding ELFV_dehydrog PF00208.21 EFX06631.1 - 0.18 11.5 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Met_10 PF02475.16 EFX06632.1 - 0.00013 21.8 0.0 0.00095 19.0 0.0 2.1 2 0 0 2 2 2 1 Met-10+ like-protein p450 PF00067.22 EFX06633.1 - 1.1e-62 212.3 0.0 1.3e-62 212.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M41 PF01434.18 EFX06634.1 - 5.6e-57 192.7 0.1 1.4e-56 191.4 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EFX06634.1 - 3.5e-37 127.8 0.0 7.9e-37 126.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFX06634.1 - 1.6e-09 37.4 0.1 3.4e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFX06634.1 - 4.9e-06 26.6 0.1 2.2e-05 24.4 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFX06634.1 - 6.2e-05 22.4 0.0 0.00013 21.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EFX06634.1 - 6.4e-05 23.4 0.8 0.00055 20.4 0.8 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFX06634.1 - 0.00016 22.0 0.4 0.035 14.4 0.1 3.3 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 EFX06634.1 - 0.0019 17.9 0.0 0.0041 16.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EFX06634.1 - 0.0035 17.1 0.1 0.0082 15.9 0.1 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EFX06634.1 - 0.0062 16.7 0.0 0.022 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFX06634.1 - 0.013 15.7 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EFX06634.1 - 0.022 14.1 0.2 0.045 13.1 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFX06634.1 - 0.037 14.6 0.0 0.094 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFX06634.1 - 0.044 13.0 1.2 0.73 9.1 0.5 2.5 1 1 1 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EFX06634.1 - 0.069 12.7 1.1 1.1 8.8 0.3 2.4 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 EFX06634.1 - 0.079 12.5 0.2 0.52 9.8 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 EFX06634.1 - 0.085 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain EMC1_C PF07774.13 EFX06634.1 - 0.2 11.3 0.4 0.88 9.2 0.1 2.0 2 0 0 2 2 2 0 ER membrane protein complex subunit 1, C-terminal FMO-like PF00743.19 EFX06635.1 - 2e-13 49.6 0.0 5.2e-13 48.3 0.0 1.5 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX06635.1 - 2.5e-09 36.8 0.0 7.7e-09 35.2 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFX06635.1 - 5.4e-06 25.8 0.0 1.3e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFX06635.1 - 1.2e-05 25.4 0.1 0.00014 22.0 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFX06635.1 - 8.6e-05 21.9 0.0 0.00023 20.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EFX06635.1 - 0.017 14.5 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RsmJ PF04378.13 EFX06635.1 - 0.044 13.0 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ DUF3748 PF12566.8 EFX06635.1 - 0.09 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) GIDA PF01134.22 EFX06635.1 - 0.15 11.2 0.1 5.2 6.0 0.4 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A DAO PF01266.24 EFX06635.1 - 7.5 6.0 8.0 23 4.4 1.6 3.0 1 1 0 3 3 3 0 FAD dependent oxidoreductase Cellulase PF00150.18 EFX06636.1 - 3e-44 151.6 0.0 4.5e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SOG2 PF10428.9 EFX06636.1 - 0.26 10.4 13.2 0.35 10.0 13.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 EFX06636.1 - 9.9 4.9 11.0 18 4.0 11.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain OTCace_N PF02729.21 EFX06637.1 - 4e-42 143.7 0.0 6e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EFX06637.1 - 7.8e-36 123.5 0.0 1.2e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Glyco_hydro_4 PF02056.16 EFX06637.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase AMP-binding PF00501.28 EFX06638.1 - 6.5e-39 133.7 0.0 1e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFX06638.1 - 0.00077 20.4 0.0 0.0015 19.4 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ABC_tran PF00005.27 EFX06639.1 - 6.8e-41 140.0 0.2 2.7e-27 95.9 0.0 2.6 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EFX06639.1 - 2.6e-14 53.6 14.5 2e-07 31.0 0.6 4.5 3 2 1 4 4 4 2 ABC transporter transmembrane region AAA_21 PF13304.6 EFX06639.1 - 1.7e-11 44.5 4.0 0.0045 16.8 0.1 3.3 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFX06639.1 - 1e-10 41.4 1.5 0.00016 21.2 0.1 3.4 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFX06639.1 - 2.2e-07 31.3 1.3 0.02 15.2 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFX06639.1 - 2.3e-07 30.5 2.3 0.016 15.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFX06639.1 - 8e-06 25.9 1.0 0.039 13.8 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFX06639.1 - 9.9e-06 25.6 0.1 0.09 12.9 0.0 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EFX06639.1 - 1.1e-05 25.9 0.2 0.26 11.7 0.2 2.8 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 EFX06639.1 - 4.7e-05 23.5 1.0 0.013 15.6 0.2 2.5 2 0 0 2 2 2 1 Dynamin family AAA_23 PF13476.6 EFX06639.1 - 4.7e-05 24.0 1.3 0.21 12.1 0.4 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EFX06639.1 - 7.8e-05 22.5 0.0 0.39 10.4 0.0 2.4 2 1 0 2 2 2 2 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EFX06639.1 - 0.00063 19.2 0.6 0.72 9.2 0.1 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family DUF87 PF01935.17 EFX06639.1 - 0.00077 19.6 0.9 0.088 12.9 0.0 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_18 PF13238.6 EFX06639.1 - 0.00078 20.0 0.0 2.2 8.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EFX06639.1 - 0.00099 18.2 0.4 0.36 9.9 0.2 2.5 2 1 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 EFX06639.1 - 0.0013 18.3 0.5 2.3 7.7 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EFX06639.1 - 0.0029 17.8 0.0 0.27 11.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain Adeno_IVa2 PF02456.15 EFX06639.1 - 0.0043 15.9 0.5 0.045 12.5 0.1 2.1 2 0 0 2 2 2 1 Adenovirus IVa2 protein cobW PF02492.19 EFX06639.1 - 0.0055 16.3 1.5 0.054 13.1 0.3 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EFX06639.1 - 0.0088 16.0 0.8 2.2 8.2 0.1 2.9 3 0 0 3 3 3 1 NACHT domain AAA_24 PF13479.6 EFX06639.1 - 0.0094 15.7 0.0 4 7.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFX06639.1 - 0.025 14.3 0.3 2 8.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.14 EFX06639.1 - 0.029 14.4 1.3 8.7 6.3 0.1 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EFX06639.1 - 0.031 13.5 0.2 0.34 10.2 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EFX06639.1 - 0.037 14.4 0.1 23 5.4 0.0 3.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFX06639.1 - 0.039 13.5 0.1 4.4 6.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 EFX06639.1 - 0.045 13.5 0.0 6.5 6.5 0.0 3.2 3 1 0 3 3 3 0 DEAD/DEAH box helicase dNK PF01712.19 EFX06639.1 - 0.13 12.1 0.0 7.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_28 PF13521.6 EFX06639.1 - 0.13 12.5 0.2 5.8 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EFX06639.1 - 0.17 11.6 0.1 3.2 7.5 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Roc PF08477.13 EFX06639.1 - 0.18 12.0 0.4 25 5.1 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EFX06639.1 - 0.19 12.1 0.0 34 4.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 EFX06639.1 - 0.19 11.1 0.1 9 5.6 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA12 PF10443.9 EFX06639.1 - 0.21 10.2 0.3 0.63 8.7 0.0 1.8 2 0 0 2 2 2 0 RNA12 protein Pox_A32 PF04665.12 EFX06639.1 - 0.23 10.9 1.5 23 4.3 0.1 2.9 3 0 0 3 3 3 0 Poxvirus A32 protein A_deaminase PF00962.22 EFX06640.1 - 2.6e-67 227.5 0.0 3e-67 227.3 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Ploopntkinase1 PF18748.1 EFX06640.1 - 0.21 11.1 0.0 19 4.7 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 Acetyltransf_1 PF00583.25 EFX06641.1 - 2.9e-09 37.2 0.0 7.9e-09 35.8 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFX06641.1 - 1.3e-06 28.7 0.0 3.8e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 EFX06641.1 - 2.9e-06 27.9 0.0 0.057 14.1 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFX06641.1 - 2.1e-05 24.4 0.0 0.0044 17.0 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFX06641.1 - 0.00034 20.7 0.0 0.001 19.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFX06641.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFX06641.1 - 0.0023 18.0 0.0 0.0039 17.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EFX06641.1 - 0.1 13.3 0.0 2.8 8.6 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Phosphoesterase PF04185.14 EFX06642.1 - 7.6e-33 114.2 0.8 4.3e-32 111.7 0.8 1.9 1 1 0 1 1 1 1 Phosphoesterase family Sulfatase PF00884.23 EFX06642.1 - 0.023 14.1 0.1 0.049 13.0 0.1 1.4 1 1 0 1 1 1 0 Sulfatase Ribosomal_S8e PF01201.22 EFX06643.1 - 3.7e-57 192.3 1.0 4.2e-57 192.1 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e SMAP PF15477.6 EFX06643.1 - 0.1 13.6 1.4 0.19 12.7 0.2 2.0 2 0 0 2 2 2 0 Small acidic protein family ABC_tran PF00005.27 EFX06644.1 - 6.2e-43 146.6 0.0 1.4e-24 87.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFX06644.1 - 1.1e-30 107.2 25.2 5.3e-17 62.4 7.3 3.6 3 1 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EFX06644.1 - 4.8e-09 36.0 1.7 0.091 12.2 0.0 4.2 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFX06644.1 - 4.6e-07 29.9 1.4 0.2 11.4 0.0 4.1 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 EFX06644.1 - 6e-07 29.1 0.1 0.0028 17.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_29 PF13555.6 EFX06644.1 - 6.6e-07 29.0 0.9 0.027 14.2 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFX06644.1 - 1e-06 29.2 2.8 0.004 17.6 0.3 2.7 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFX06644.1 - 2.3e-06 27.6 0.8 0.01 15.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 EFX06644.1 - 2.9e-06 27.5 0.9 0.0022 18.2 0.1 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFX06644.1 - 3e-06 27.5 1.5 0.016 15.5 0.3 3.1 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EFX06644.1 - 1.5e-05 24.9 0.3 0.1 12.3 0.1 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Dynamin_N PF00350.23 EFX06644.1 - 1.8e-05 24.9 1.7 0.044 13.8 0.1 2.6 2 0 0 2 2 2 2 Dynamin family AAA_23 PF13476.6 EFX06644.1 - 3.1e-05 24.6 0.0 0.046 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EFX06644.1 - 3.2e-05 23.6 5.6 0.0018 17.9 0.2 3.4 4 0 0 4 4 3 1 AAA domain RsgA_GTPase PF03193.16 EFX06644.1 - 6e-05 23.0 1.8 0.27 11.1 0.2 2.4 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 EFX06644.1 - 7.9e-05 21.8 3.1 0.022 13.8 0.1 2.6 3 0 0 3 3 3 2 Type II/IV secretion system protein DUF87 PF01935.17 EFX06644.1 - 0.00024 21.3 6.0 0.0037 17.4 0.1 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain NACHT PF05729.12 EFX06644.1 - 0.0012 18.8 0.8 0.9 9.4 0.1 2.8 2 0 0 2 2 2 1 NACHT domain SbcCD_C PF13558.6 EFX06644.1 - 0.0016 18.6 0.4 8.4 6.7 0.0 4.2 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit Pox_A32 PF04665.12 EFX06644.1 - 0.0026 17.3 0.6 0.79 9.1 0.0 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_30 PF13604.6 EFX06644.1 - 0.0031 17.3 7.3 0.92 9.2 1.9 4.0 3 1 0 3 3 3 1 AAA domain ABC_ATPase PF09818.9 EFX06644.1 - 0.004 16.0 1.7 0.17 10.7 0.1 3.1 4 0 0 4 4 4 1 Predicted ATPase of the ABC class cobW PF02492.19 EFX06644.1 - 0.0082 15.7 5.9 0.68 9.5 0.2 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 EFX06644.1 - 0.009 15.3 0.2 1.7 7.9 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 EFX06644.1 - 0.01 15.6 0.2 1.9 8.1 0.0 2.7 3 0 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 EFX06644.1 - 0.013 14.4 0.3 3.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NB-ARC PF00931.22 EFX06644.1 - 0.013 14.7 0.2 0.57 9.3 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain Adeno_IVa2 PF02456.15 EFX06644.1 - 0.041 12.7 0.2 6.8 5.4 0.1 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein Septin PF00735.18 EFX06644.1 - 0.061 12.6 0.1 1.5 8.0 0.0 2.1 2 0 0 2 2 2 0 Septin DUF2075 PF09848.9 EFX06644.1 - 0.11 11.7 0.4 1.4 8.1 0.2 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EFX06644.1 - 0.11 12.3 2.1 6.3 6.7 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 EFX06644.1 - 0.12 12.5 0.1 15 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 EFX06644.1 - 0.13 11.4 1.1 8.8 5.4 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_18 PF13238.6 EFX06644.1 - 0.16 12.5 2.7 12 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EFX06644.1 - 0.2 11.9 0.0 6.9 6.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EFX06644.1 - 0.24 10.9 0.3 5.7 6.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 EFX06644.1 - 0.41 10.9 3.4 7.1 6.8 0.7 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EFX06644.1 - 0.73 9.8 3.3 27 4.7 0.1 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF4022 PF13214.6 EFX06644.1 - 3.1 8.1 6.2 55 4.1 0.1 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4022) DENN PF02141.21 EFX06645.1 - 3.2e-39 134.8 0.1 5.3e-39 134.1 0.1 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain zf-HIT PF04438.16 EFX06645.1 - 5.1e-10 39.0 9.8 8.9e-10 38.3 9.8 1.4 1 0 0 1 1 1 1 HIT zinc finger uDENN PF03456.18 EFX06645.1 - 1.1e-06 29.3 0.5 4.9e-06 27.2 0.0 2.4 2 0 0 2 2 2 1 uDENN domain zf-MYND PF01753.18 EFX06645.1 - 0.02 15.0 7.2 0.041 14.0 7.2 1.5 1 0 0 1 1 1 0 MYND finger Elongin_A PF06881.11 EFX06645.1 - 0.031 14.8 5.0 0.12 12.9 5.0 2.0 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A YL1_C PF08265.11 EFX06645.1 - 0.18 11.6 0.0 0.45 10.3 0.0 1.6 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain DUF3450 PF11932.8 EFX06645.1 - 6.9 5.9 16.7 1.5 8.1 3.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) LIP PF03583.14 EFX06646.1 - 3.3e-81 272.8 0.1 5.1e-81 272.1 0.1 1.1 1 0 0 1 1 1 1 Secretory lipase Sperm_Ag_HE2 PF05324.13 EFX06646.1 - 0.16 12.5 0.1 0.35 11.4 0.1 1.5 1 0 0 1 1 1 0 Sperm antigen HE2 Baculo_Y142 PF04913.12 EFX06647.1 - 0.1 11.2 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Baculovirus Y142 protein Ufd2P_core PF10408.9 EFX06648.1 - 2.7e-212 706.8 1.3 3.3e-212 706.5 1.3 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EFX06648.1 - 3.1e-26 91.3 0.8 1.1e-25 89.6 0.8 2.0 1 0 0 1 1 1 1 U-box domain Efg1 PF10153.9 EFX06648.1 - 0.38 11.1 2.7 0.41 11.0 0.5 2.1 2 0 0 2 2 2 0 rRNA-processing protein Efg1 OmpH PF03938.14 EFX06648.1 - 0.74 10.2 6.7 0.49 10.7 3.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF2203 PF09969.9 EFX06648.1 - 1.4 9.7 3.7 0.65 10.7 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) P21-Arc PF04062.14 EFX06650.1 - 1e-71 240.5 0.0 4.3e-71 238.5 0.0 1.8 2 0 0 2 2 2 1 ARP2/3 complex ARPC3 (21 kDa) subunit tRNA-synt_His PF13393.6 EFX06651.1 - 1.3e-39 136.3 0.8 1.7e-38 132.7 0.8 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EFX06651.1 - 7.2e-08 32.5 0.0 1.6e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EFX06651.1 - 0.0028 16.8 0.0 0.052 12.6 0.0 2.3 1 1 1 2 2 2 1 tRNA synthetases class II (D, K and N) 2OG-FeII_Oxy_2 PF13532.6 EFX06651.1 - 0.051 13.8 0.0 0.096 12.9 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily HGTP_anticodon2 PF12745.7 EFX06651.1 - 0.13 11.8 0.0 0.36 10.3 0.0 1.7 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs MRP-S25 PF13741.6 EFX06654.1 - 6.6e-66 222.2 5.2 1.4e-62 211.2 5.2 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EFX06654.1 - 0.026 14.8 2.0 0.051 13.8 1.8 1.8 1 1 0 1 1 1 0 Mitochondrial ribosomal protein S23 PRMT5_TIM PF17285.2 EFX06655.1 - 4.3e-71 239.1 0.0 5.9e-71 238.7 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 EFX06655.1 - 1.5e-64 217.0 0.0 3.4e-64 215.8 0.0 1.5 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EFX06655.1 - 1.2e-58 197.9 0.0 2e-58 197.1 0.0 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain DUF3445 PF11927.8 EFX06656.1 - 2e-57 194.4 0.0 1.1e-44 152.8 0.0 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3445) Abhydrolase_1 PF00561.20 EFX06657.1 - 4.8e-10 39.5 0.2 2.1e-09 37.4 0.0 1.8 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFX06657.1 - 4.8e-10 40.4 11.3 4.8e-10 40.4 11.3 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFX06657.1 - 0.00063 19.1 0.1 0.0016 17.7 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 EthD PF07110.11 EFX06657.1 - 0.0048 18.0 0.1 0.23 12.6 0.0 3.2 2 1 0 2 2 2 1 EthD domain Ndr PF03096.14 EFX06657.1 - 0.083 11.6 0.0 0.28 9.9 0.0 1.7 1 1 0 1 1 1 0 Ndr family GNAT_like PF18407.1 EFX06657.1 - 0.82 10.1 5.1 5.7 7.4 0.2 3.3 3 0 0 3 3 3 0 GCN5-related N-acetyltransferase like domain zf-H2C2_2 PF13465.6 EFX06658.1 - 6.6e-16 57.9 23.9 4e-06 27.0 0.2 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 EFX06658.1 - 7.2e-16 57.7 31.6 1.4e-06 28.4 0.2 4.9 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFX06658.1 - 1.8e-05 25.2 27.0 0.11 13.3 2.4 5.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFX06658.1 - 0.02 15.2 1.2 10 6.5 0.1 3.6 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 EFX06658.1 - 1.6 9.5 12.3 0.14 12.9 3.9 2.9 1 1 2 3 3 3 0 TRAF-type zinc finger zf-met PF12874.7 EFX06658.1 - 2.8 8.5 10.5 10 6.7 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EFX06658.1 - 5.7 7.1 7.0 4.1 7.5 0.2 2.5 1 1 2 3 3 3 0 Aberrant zinc-finger FOXP-CC PF16159.5 EFX06658.1 - 7.4 7.3 13.6 20 5.9 0.1 4.1 3 1 1 4 4 4 0 FOXP coiled-coil domain Amidase PF01425.21 EFX06659.1 - 1.2e-83 281.6 0.0 6.5e-83 279.2 0.0 2.1 2 1 0 2 2 2 1 Amidase LssY_C PF14067.6 EFX06659.1 - 0.1 12.1 0.1 0.24 10.9 0.2 1.5 2 0 0 2 2 2 0 LssY C-terminus Fusion_gly_K PF01621.17 EFX06659.1 - 0.21 10.6 0.1 0.32 10.0 0.1 1.2 1 0 0 1 1 1 0 Cell fusion glycoprotein K Podoplanin PF05808.11 EFX06660.1 - 0.015 15.4 0.6 0.03 14.4 0.6 1.5 1 0 0 1 1 1 0 Podoplanin COX14 PF14880.6 EFX06660.1 - 0.04 13.8 0.1 0.088 12.7 0.1 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly CYYR1 PF10873.8 EFX06660.1 - 0.068 13.6 0.2 0.068 13.6 0.2 2.5 3 0 0 3 3 3 0 Cysteine and tyrosine-rich protein 1 PTR2 PF00854.21 EFX06661.1 - 4.2e-43 147.7 1.1 5.7e-43 147.2 1.1 1.1 1 0 0 1 1 1 1 POT family G_glu_transpept PF01019.21 EFX06662.1 - 4.5e-155 517.3 2.8 5.2e-155 517.1 2.8 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase SpdB PF05122.13 EFX06662.1 - 0.38 10.9 0.1 0.38 10.9 0.1 2.8 3 0 0 3 3 3 0 Mobile element transfer protein Ribosomal_S25 PF03297.15 EFX06663.1 - 1e-37 128.4 7.3 1.1e-37 128.3 7.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein RNA_pol_Rpc34 PF05158.12 EFX06663.1 - 0.00038 19.9 1.4 0.00047 19.6 0.3 1.5 1 1 1 2 2 2 1 RNA polymerase Rpc34 subunit HTH_24 PF13412.6 EFX06663.1 - 0.01 15.4 0.1 0.016 14.8 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_DeoR PF08220.12 EFX06663.1 - 0.05 13.4 0.2 0.073 12.8 0.2 1.4 1 1 0 1 1 1 0 DeoR-like helix-turn-helix domain MarR_2 PF12802.7 EFX06663.1 - 0.061 13.2 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 MarR family TrmB PF01978.19 EFX06663.1 - 0.074 12.9 0.4 0.096 12.6 0.4 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EFX06663.1 - 0.08 12.9 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 HTH domain Rrf2 PF02082.20 EFX06663.1 - 0.093 13.1 0.1 0.14 12.6 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator Pex14_N PF04695.13 EFX06664.1 - 5.4e-25 88.9 2.5 5.4e-25 88.9 2.5 3.3 2 1 1 3 3 3 2 Peroxisomal membrane anchor protein (Pex14p) conserved region RecX PF02631.16 EFX06664.1 - 0.011 16.2 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 RecX family Coprogen_oxidas PF01218.18 EFX06665.1 - 3.2e-134 446.3 0.0 4e-134 446.0 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase SWIM PF04434.17 EFX06665.1 - 0.33 10.7 1.5 34 4.2 0.0 2.5 2 0 0 2 2 2 0 SWIM zinc finger WLM PF08325.10 EFX06666.1 - 1.3e-47 162.4 0.0 3e-47 161.2 0.0 1.6 1 1 1 2 2 2 1 WLM domain DUF45 PF01863.17 EFX06666.1 - 0.0074 16.3 2.5 0.0079 16.3 0.9 1.7 2 0 0 2 2 2 1 Protein of unknown function DUF45 Aminotran_5 PF00266.19 EFX06666.1 - 0.032 13.2 0.0 0.046 12.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V ssDBP PF17878.1 EFX06666.1 - 0.12 12.6 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Single-stranded DNA-binding protein HET PF06985.11 EFX06667.1 - 2.5e-20 73.3 0.0 7.3e-20 71.8 0.0 1.9 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.7 EFX06667.1 - 2.8e-09 37.4 0.6 6.7e-08 33.0 0.1 2.9 2 2 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX06667.1 - 3e-07 30.8 0.4 0.0052 17.3 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFX06667.1 - 1.1e-06 28.7 1.2 0.068 13.5 0.1 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06667.1 - 6.1e-05 23.1 0.5 0.23 12.2 0.1 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFX06667.1 - 0.0024 18.3 2.1 9.5 6.9 0.2 4.0 4 0 0 4 4 4 1 Ankyrin repeat adh_short PF00106.25 EFX06668.1 - 3.2e-18 65.9 0.0 1.7e-15 57.0 0.2 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFX06668.1 - 4.2e-10 39.6 0.1 2.3e-07 30.6 0.2 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFX06668.1 - 5.7e-07 29.6 0.7 1.3e-06 28.4 0.2 1.8 2 0 0 2 2 2 1 KR domain Perilipin PF03036.16 EFX06670.1 - 0.0035 16.4 0.0 0.0065 15.5 0.0 1.6 1 1 0 1 1 1 1 Perilipin family PET10 PF17316.2 EFX06670.1 - 0.12 11.9 0.0 0.3 10.6 0.0 1.6 1 1 1 2 2 2 0 Petite colonies protein 10 Ank_2 PF12796.7 EFX06671.1 - 4.5e-61 203.4 12.9 1.1e-17 64.4 0.3 4.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFX06671.1 - 4.1e-45 151.6 14.4 7.8e-10 39.1 0.1 7.1 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EFX06671.1 - 7.2e-43 143.2 12.0 6.7e-07 29.5 0.0 8.1 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 EFX06671.1 - 3.4e-33 109.9 1.4 0.00024 21.3 0.0 8.3 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 EFX06671.1 - 9.3e-27 92.8 7.4 1.9e-07 31.2 0.2 6.1 2 2 3 6 6 6 5 Ankyrin repeats (many copies) NACHT_N PF17100.5 EFX06671.1 - 2e-17 63.8 2.3 2e-17 63.8 2.3 2.2 2 1 0 2 2 2 1 N-terminal domain of NWD NACHT-NTPase NACHT PF05729.12 EFX06671.1 - 2.1e-05 24.5 0.1 0.0035 17.3 0.0 3.0 3 0 0 3 3 3 1 NACHT domain AAA_16 PF13191.6 EFX06671.1 - 0.011 16.2 0.1 0.041 14.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Sec16_C PF12931.7 EFX06673.1 - 2.5e-09 37.2 0.2 1.1e-08 35.1 0.3 1.9 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 SRA1 PF07304.11 EFX06673.1 - 5e-09 36.1 0.1 5e-09 36.1 0.1 3.2 3 1 1 4 4 4 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 EFX06673.1 - 2.8e-06 28.0 0.1 0.092 13.6 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFX06673.1 - 0.00057 20.1 0.3 0.0061 16.8 0.1 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Prp18 PF02840.15 EFX06673.1 - 0.16 12.0 0.1 0.49 10.4 0.1 1.8 1 0 0 1 1 1 0 Prp18 domain DUF3328 PF11807.8 EFX06675.1 - 8.9e-28 97.6 0.0 1.1e-27 97.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Fungal_trans PF04082.18 EFX06676.1 - 9.4e-12 44.5 0.0 1.5e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2407_C PF13373.6 EFX06677.1 - 4.9e-37 127.2 0.0 8.1e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EFX06677.1 - 6.1e-19 68.5 0.0 2.5e-09 37.6 0.0 2.3 2 0 0 2 2 2 2 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EFX06677.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Ribosomal_L19e PF01280.20 EFX06677.1 - 0.15 12.1 0.6 0.36 10.9 0.6 1.6 1 0 0 1 1 1 0 Ribosomal protein L19e ER_lumen_recept PF00810.18 EFX06678.1 - 2.7e-54 184.0 8.0 4.7e-54 183.2 8.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EFX06678.1 - 0.0053 16.5 10.5 0.21 11.4 0.8 3.6 3 1 1 4 4 4 2 PQ loop repeat Aminotran_1_2 PF00155.21 EFX06679.1 - 1.4e-65 221.9 0.0 3.3e-65 220.6 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II AA_permease PF00324.21 EFX06681.1 - 1.6e-98 330.4 33.4 1.9e-98 330.2 33.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EFX06681.1 - 5.3e-30 104.6 36.9 6.9e-30 104.2 36.9 1.0 1 0 0 1 1 1 1 Amino acid permease B277 PF17623.2 EFX06681.1 - 2.1 7.3 3.6 8.5 5.4 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function RNA_pol_Rpb1_5 PF04998.17 EFX06682.1 - 2.7e-86 289.3 0.1 4.3e-86 288.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFX06682.1 - 3.2e-68 229.1 0.1 6.2e-68 228.2 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EFX06682.1 - 1.8e-31 109.7 0.0 2.7e-30 105.8 0.0 2.7 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 EFX06682.1 - 7.4e-28 97.5 0.0 1.8e-27 96.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 DDHD PF02862.17 EFX06682.1 - 1.4e-23 84.2 0.1 2.9e-21 76.7 0.0 3.7 2 1 0 2 2 2 1 DDHD domain RNA_pol_Rpb1_4 PF05000.17 EFX06682.1 - 3.6e-15 55.8 0.0 1.4e-14 53.9 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Abhydrolase_6 PF12697.7 EFX06682.1 - 6.1 7.4 10.0 0.26 11.9 1.7 2.8 3 1 0 3 3 3 0 Alpha/beta hydrolase family Utp12 PF04003.12 EFX06683.1 - 5.5e-22 78.1 0.0 8.6e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family UTP15_C PF09384.10 EFX06683.1 - 0.14 11.9 0.0 0.35 10.5 0.0 1.7 1 1 0 1 1 1 0 UTP15 C terminal S36_mt PF10937.8 EFX06684.1 - 6.3e-38 130.9 0.2 7.5e-38 130.7 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Skp1_POZ PF03931.15 EFX06685.1 - 1.6e-07 31.3 0.0 2.3e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain OAS1_C PF10421.9 EFX06685.1 - 0.028 13.9 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus BTB PF00651.31 EFX06685.1 - 0.041 14.1 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Pyr_redox_2 PF07992.14 EFX06686.1 - 2.1e-22 79.7 0.0 5.5e-19 68.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EFX06686.1 - 1.4e-17 63.4 0.2 2.3e-14 52.8 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFX06686.1 - 2.7e-14 53.1 0.0 2.9e-12 46.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX06686.1 - 1.7e-12 47.4 0.1 8.2e-10 38.8 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFX06686.1 - 1.9e-11 43.7 0.0 1.7e-10 40.6 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EFX06686.1 - 1.6e-08 34.6 0.1 0.01 15.4 0.0 3.4 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFX06686.1 - 4.9e-08 33.1 0.3 0.31 11.0 0.0 4.2 4 0 0 4 4 4 2 FAD-NAD(P)-binding Pyr_redox PF00070.27 EFX06686.1 - 0.00013 22.5 0.7 0.32 11.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX06686.1 - 0.00025 20.2 1.2 0.00061 19.0 0.0 2.1 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 EFX06686.1 - 0.00062 19.1 0.9 0.16 11.2 0.1 2.5 3 0 0 3 3 3 2 Thi4 family GIDA PF01134.22 EFX06686.1 - 0.0012 18.0 0.5 3.2 6.7 0.1 3.1 3 0 0 3 3 3 2 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EFX06686.1 - 0.0037 16.4 0.0 0.82 8.7 0.0 3.5 3 1 0 3 3 3 1 Lycopene cyclase protein HI0933_like PF03486.14 EFX06686.1 - 0.0058 15.4 3.8 0.1 11.3 0.1 3.4 4 1 0 4 4 4 1 HI0933-like protein Amino_oxidase PF01593.24 EFX06686.1 - 0.011 15.1 1.1 3 7.0 0.0 3.6 3 1 0 4 4 4 0 Flavin containing amine oxidoreductase NAD_binding_7 PF13241.6 EFX06686.1 - 0.014 15.9 0.0 2.4 8.6 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFX06686.1 - 0.029 14.4 0.1 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EFX06686.1 - 0.65 9.6 2.0 2.4 7.8 0.7 2.4 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA OCD_Mu_crystall PF02423.15 EFX06687.1 - 1.3e-12 47.3 2.0 3e-10 39.5 1.1 3.1 2 1 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EFX06687.1 - 2.8e-09 37.2 0.2 5e-06 26.6 0.2 2.2 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EFX06687.1 - 0.011 15.0 0.6 0.022 14.0 0.6 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EFX06687.1 - 0.021 15.1 0.1 0.036 14.3 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFX06687.1 - 0.027 14.4 0.8 0.056 13.3 0.8 1.6 1 1 0 1 1 1 0 NAD(P)H-binding GFO_IDH_MocA PF01408.22 EFX06687.1 - 0.027 15.3 0.3 0.044 14.6 0.3 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold NmrA PF05368.13 EFX06687.1 - 0.042 13.4 0.1 0.059 12.9 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family NAD_binding_7 PF13241.6 EFX06687.1 - 0.12 12.8 0.3 0.24 11.9 0.3 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Abhydrolase_6 PF12697.7 EFX06688.1 - 6.3e-17 62.9 6.1 8.2e-17 62.5 6.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX06688.1 - 7.4e-16 58.6 0.0 3.9e-15 56.2 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFX06688.1 - 1.4e-09 37.5 0.1 1e-08 34.7 0.1 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EFX06688.1 - 0.00022 21.1 0.0 0.027 14.3 0.0 2.6 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Chlorophyllase2 PF12740.7 EFX06688.1 - 0.047 12.6 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme F-box PF00646.33 EFX06689.1 - 0.0079 16.1 0.0 0.02 14.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFX06689.1 - 0.13 12.1 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 F-box-like GMC_oxred_N PF00732.19 EFX06690.1 - 1.7e-77 260.7 0.0 2.4e-77 260.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFX06690.1 - 2.6e-35 122.1 0.0 5.6e-35 121.0 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EFX06690.1 - 0.00023 20.4 1.0 0.00024 20.3 0.1 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EFX06690.1 - 0.0054 16.4 3.5 0.044 13.4 3.5 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFX06690.1 - 0.011 14.9 0.2 2.9 6.9 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.14 EFX06690.1 - 0.016 14.4 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EFX06690.1 - 0.094 13.0 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 EFX06690.1 - 0.13 12.8 0.2 0.33 11.5 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFX06690.1 - 0.18 12.1 0.2 0.53 10.6 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain F-box PF00646.33 EFX06692.1 - 0.0016 18.3 0.9 0.0016 18.3 0.9 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFX06692.1 - 0.0068 16.3 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 F-box-like BC10 PF06726.12 EFX06693.1 - 6.1e-17 61.6 11.3 9.4e-17 61.0 11.3 1.3 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Cir_N PF10197.9 EFX06694.1 - 1.3e-06 28.5 2.2 1.3e-06 28.5 2.2 4.5 3 1 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR FTZ PF03867.14 EFX06694.1 - 1.1 8.8 5.5 0.24 10.9 1.1 1.9 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Glyco_hydro_18 PF00704.28 EFX06695.1 - 1.7e-59 202.1 2.9 2.9e-59 201.4 2.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Hydrolase_4 PF12146.8 EFX06696.1 - 1.2e-11 44.4 0.1 3e-11 43.1 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFX06696.1 - 2.1e-11 44.9 13.2 2.7e-11 44.5 13.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFX06696.1 - 2e-10 40.8 0.1 6.1e-10 39.2 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_M56 PF05569.11 EFX06698.1 - 0.06 12.5 0.0 0.06 12.5 0.0 2.4 1 1 1 2 2 2 0 BlaR1 peptidase M56 Amnionless PF14828.6 EFX06698.1 - 0.062 12.1 0.1 0.062 12.1 0.1 1.7 1 1 0 2 2 2 0 Amnionless Phage_holin_2_4 PF16082.5 EFX06698.1 - 6.4 6.6 6.4 0.63 9.8 0.3 2.6 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Pkinase PF00069.25 EFX06699.1 - 6e-12 45.5 0.0 8.4e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFX06699.1 - 0.00029 19.8 0.1 0.00036 19.4 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFX06699.1 - 0.011 15.7 0.1 0.052 13.5 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 EFX06699.1 - 0.019 14.3 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.14 EFX06699.1 - 0.059 12.7 1.1 0.089 12.1 0.5 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhyH PF05721.13 EFX06701.1 - 4.4e-20 72.8 0.0 5.3e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFX06701.1 - 0.17 10.6 0.0 0.3 9.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) 2-Hacid_dh_C PF02826.19 EFX06702.1 - 2e-52 177.2 0.0 2.7e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFX06702.1 - 1.9e-15 56.7 0.0 2.4e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFX06702.1 - 7.8e-07 29.4 0.2 1.4e-06 28.5 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFX06702.1 - 0.025 15.2 0.0 0.054 14.1 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EFX06702.1 - 0.096 12.3 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EFX06702.1 - 0.17 11.8 0.2 0.24 11.3 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Mito_carr PF00153.27 EFX06704.1 - 5.5e-67 221.8 3.0 2.6e-24 85.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Dcc1 PF09724.9 EFX06704.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 His_Phos_2 PF00328.22 EFX06705.1 - 6.3e-35 121.2 0.0 8.3e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) COX6B PF02297.17 EFX06706.1 - 2.1e-18 66.3 5.4 2.5e-18 66.1 5.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EFX06706.1 - 0.01 15.8 1.4 0.017 15.1 1.4 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EFX06706.1 - 0.047 13.6 0.8 0.047 13.6 0.8 1.5 1 1 0 1 1 1 0 APOBEC-like C-terminal domain ketoacyl-synt PF00109.26 EFX06706.1 - 0.11 12.1 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Ank_2 PF12796.7 EFX06707.1 - 4.2e-12 46.5 0.2 7.9e-11 42.4 0.2 2.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFX06707.1 - 9.5e-10 38.5 0.0 1.6e-05 25.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFX06707.1 - 3.6e-09 36.7 0.0 0.0019 18.6 0.0 3.4 3 1 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EFX06707.1 - 1e-08 35.5 0.0 0.00059 20.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFX06707.1 - 3.6e-08 33.0 0.0 0.034 14.7 0.0 4.4 4 1 0 4 4 4 2 Ankyrin repeat CorA PF01544.18 EFX06707.1 - 0.00011 21.6 0.1 0.00021 20.7 0.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Fungal_trans PF04082.18 EFX06708.1 - 3.4e-10 39.4 0.0 6.5e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_8 PF13450.6 EFX06708.1 - 9.7e-08 32.1 0.7 2.7e-07 30.7 0.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX06708.1 - 7.5e-07 29.0 0.5 1.5e-06 28.1 0.5 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFX06708.1 - 8.9e-06 25.3 0.3 1.7e-05 24.3 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFX06708.1 - 5.4e-05 22.6 0.0 0.00011 21.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFX06708.1 - 0.00096 18.3 3.0 0.0022 17.2 2.8 1.7 1 1 1 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 EFX06708.1 - 0.003 16.8 2.7 0.83 8.8 1.2 2.2 2 0 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.24 EFX06708.1 - 0.012 14.9 0.1 0.021 14.1 0.1 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GIDA PF01134.22 EFX06708.1 - 0.017 14.2 0.9 0.026 13.6 0.9 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EFX06708.1 - 0.025 13.9 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EFX06708.1 - 0.031 13.0 1.1 0.045 12.5 1.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EFX06708.1 - 0.055 14.0 1.1 0.18 12.4 1.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.12 EFX06708.1 - 0.089 12.4 0.0 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lipase_GDSL_2 PF13472.6 EFX06710.1 - 5.8e-17 62.6 0.5 8.6e-17 62.1 0.5 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.6 EFX06710.1 - 7.9e-06 26.1 0.0 1.6e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFX06710.1 - 1.3e-05 25.3 0.2 3.8e-05 23.8 0.2 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase FF PF01846.19 EFX06711.1 - 4.7e-10 39.5 0.1 4.7e-10 39.5 0.1 3.4 4 0 0 4 4 4 1 FF domain NAD_binding_8 PF13450.6 EFX06712.1 - 1e-08 35.3 0.3 1.4e-08 34.9 0.3 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFX06712.1 - 1.1e-06 28.4 0.3 1.4e-06 28.2 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFX06712.1 - 4.4e-05 22.9 0.1 5.1e-05 22.7 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EFX06712.1 - 0.00011 21.4 0.8 0.00011 21.4 0.8 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFX06712.1 - 0.0003 20.1 0.2 0.0003 20.1 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFX06712.1 - 0.0007 18.6 0.2 0.00079 18.4 0.2 1.0 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.17 EFX06712.1 - 0.0011 18.3 0.2 0.0013 18.1 0.2 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EFX06712.1 - 0.0046 17.5 0.1 0.0051 17.4 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFX06712.1 - 0.0073 15.6 0.3 0.009 15.3 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 EFX06712.1 - 0.0092 15.4 0.1 0.013 14.8 0.1 1.2 1 0 0 1 1 1 1 ThiF family NAD_binding_9 PF13454.6 EFX06712.1 - 0.018 15.1 0.2 0.024 14.6 0.2 1.3 1 1 0 1 1 1 0 FAD-NAD(P)-binding GIDA PF01134.22 EFX06712.1 - 0.024 13.8 0.4 0.024 13.8 0.4 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 EFX06712.1 - 0.11 12.1 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EFX06712.1 - 0.11 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EFX06712.1 - 0.19 10.4 1.0 0.23 10.1 1.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 EFX06712.1 - 0.26 10.3 0.7 0.32 10.0 0.7 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Grosmannia_clavigera_kw1407-Sanger-454-IlluminaPA_2.0/GCA_000143105.2_Sanger-454-IlluminaPA_2.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Grosmannia_clavigera_kw1407-Sanger-454-IlluminaPA_2.0/GCA_000143105.2_Sanger-454-IlluminaPA_2.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Grosmannia_clavigera_kw1407-Sanger-454-IlluminaPA_2.0/GCA_000143105.2_Sanger-454-IlluminaPA_2.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Grosmannia_clavigera_kw1407-Sanger-454-IlluminaPA_2.0/GCA_000143105.2_Sanger-454-IlluminaPA_2.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 21:02:21 2019 # [ok]