# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- zf-U11-48K PF05253.7 EFW98400.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger UQ_con PF00179.21 EFW98401.1 - 8.8e-10 38.1 0.0 1.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EFW98401.1 - 0.0079 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 RWD domain BRE PF06113.7 EFW98401.1 - 0.084 11.9 0.1 0.12 11.3 0.1 1.1 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) MFS_1 PF07690.11 EFW98402.1 - 1.2e-29 103.1 24.8 1.7e-29 102.6 17.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFW98402.1 - 0.00066 18.3 11.4 0.00066 18.3 7.9 2.5 3 1 0 3 3 3 1 Sugar (and other) transporter Mur_ligase_M PF08245.7 EFW98403.1 - 0.0052 16.8 0.0 0.11 12.5 0.0 2.3 1 1 0 1 1 1 1 Mur ligase middle domain Molybdopterin PF00384.17 EFW98404.1 - 1.7e-74 251.0 0.0 1.3e-72 244.9 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 PF10588.4 EFW98404.1 - 5.1e-19 67.2 0.1 1.5e-18 65.7 0.1 1.9 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.1 EFW98404.1 - 5.7e-19 67.7 0.1 1.5e-18 66.3 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF1982 PF09326.6 EFW98404.1 - 2.6e-14 53.1 0.0 8.6e-14 51.4 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1982) Fer2 PF00111.22 EFW98404.1 - 6e-08 32.3 0.6 6e-08 32.3 0.4 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.17 EFW98404.1 - 0.00073 19.3 0.1 0.025 14.3 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4_15 PF13459.1 EFW98404.1 - 0.061 13.9 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fer4 PF00037.22 EFW98404.1 - 0.11 12.1 1.1 3.1 7.5 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.6 EFW98404.1 - 0.12 12.2 1.7 1.2 9.0 1.2 2.4 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster DIOX_N PF14226.1 EFW98405.1 - 4.1e-24 85.3 0.0 7e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFW98405.1 - 5.7e-19 68.2 0.0 8.7e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Tom37 PF10568.4 EFW98406.1 - 0.0091 16.2 0.1 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein AUX_IAA PF02309.11 EFW98407.1 - 1 9.0 5.6 1.6 8.4 3.9 1.3 1 1 0 1 1 1 0 AUX/IAA family Zn_clus PF00172.13 EFW98408.1 - 1.9e-06 27.6 11.0 3.6e-06 26.7 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFW98408.1 - 2e-05 23.5 0.1 0.00041 19.3 0.0 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain FAD_binding_7 PF03441.9 EFW98409.1 - 7.8e-100 333.6 0.3 1.5e-99 332.7 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 EFW98409.1 - 3.8e-38 130.8 0.1 6.7e-38 130.0 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase DUSP PF06337.7 EFW98409.1 - 0.02 15.3 0.0 0.039 14.3 0.0 1.5 1 0 0 1 1 1 0 DUSP domain PPP4R2 PF09184.6 EFW98411.1 - 2.2e-10 40.5 1.6 2.2e-10 40.5 1.1 4.2 3 1 0 3 3 3 1 PPP4R2 Aldo_ket_red PF00248.16 EFW98412.1 - 2.5e-43 147.9 0.0 3e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_Tnp_4 PF13613.1 EFW98412.1 - 0.072 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HTH_AsnC-type PF13404.1 EFW98412.1 - 0.074 12.5 0.2 0.7 9.4 0.0 2.5 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Ala_racemase_N PF01168.15 EFW98412.1 - 0.098 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain Ribosomal_L3 PF00297.17 EFW98413.1 - 1.1e-30 106.8 1.5 4.4e-29 101.6 1.0 2.2 1 1 0 1 1 1 1 Ribosomal protein L3 SMN PF06003.7 EFW98414.1 - 2.4e-05 23.5 0.1 3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Strep_67kDa_ant PF06100.6 EFW98415.1 - 6.9e-115 384.2 0.0 8.1e-47 159.7 0.0 3.0 3 0 0 3 3 3 3 Streptococcal 67 kDa myosin-cross-reactive antigen like family NAD_binding_8 PF13450.1 EFW98415.1 - 0.00036 20.5 0.1 0.0016 18.4 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DUF406 PF04175.7 EFW98415.1 - 0.014 15.8 0.8 0.037 14.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF406) eIF3g PF12353.3 EFW98417.1 - 1.9e-41 140.9 0.9 2.9e-41 140.3 0.6 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 EFW98417.1 - 8.7e-17 60.5 0.1 1.5e-16 59.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98417.1 - 1.9e-13 50.2 0.1 3.2e-13 49.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW98417.1 - 2.8e-07 30.2 0.0 4.7e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L19 PF01245.15 EFW98418.1 - 5.7e-17 61.5 0.0 9.1e-17 60.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 OB_NTP_bind PF07717.11 EFW98419.1 - 2.5e-24 85.2 0.0 4.9e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFW98419.1 - 2.9e-20 72.1 0.0 8.5e-20 70.6 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFW98419.1 - 4.3e-10 39.3 0.0 9.9e-10 38.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFW98419.1 - 1.8e-05 24.8 0.0 4.8e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 EFW98419.1 - 0.00015 21.3 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase cobW PF02492.14 EFW98419.1 - 0.027 13.9 0.2 0.12 11.7 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 EFW98419.1 - 0.033 14.0 0.2 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EFW98419.1 - 0.036 13.1 0.0 0.1 11.6 0.0 1.7 1 1 0 1 1 1 0 Zeta toxin T2SE PF00437.15 EFW98419.1 - 0.046 12.6 0.1 0.098 11.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.1 EFW98419.1 - 1.3 8.7 5.8 0.43 10.3 0.1 3.0 4 0 0 4 4 4 0 Part of AAA domain Terpene_synth_C PF03936.11 EFW98420.1 - 1.1e-18 67.4 0.1 1.4e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain PSD2 PF07624.6 EFW98420.1 - 0.027 14.0 0.0 0.072 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) DUF2334 PF10096.4 EFW98420.1 - 0.08 12.3 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Abhydrolase_6 PF12697.2 EFW98422.1 - 8.5e-16 58.5 0.1 1.1e-15 58.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFW98422.1 - 0.0017 18.1 0.0 0.0032 17.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family PFK PF00365.15 EFW98422.1 - 0.079 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Phosphofructokinase AA_kinase PF00696.23 EFW98422.1 - 0.087 12.3 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Amino acid kinase family TRP PF06011.7 EFW98423.1 - 1.6e-91 307.1 24.7 6e-91 305.1 17.2 1.7 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFW98423.1 - 9e-28 97.0 1.1 1.4e-27 96.4 0.8 1.2 1 0 0 1 1 1 1 ML-like domain LtrA PF06772.6 EFW98424.1 - 7.3e-12 44.8 30.7 6.3e-11 41.7 21.3 2.2 1 1 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF3337 PF11816.3 EFW98425.1 - 6.1e-48 163.9 0.0 1.5e-45 156.0 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3337) WD40 PF00400.27 EFW98425.1 - 1.5e-26 91.2 15.6 3.9e-07 29.6 0.1 7.2 8 0 0 8 8 8 5 WD domain, G-beta repeat Nup160 PF11715.3 EFW98425.1 - 0.026 12.6 1.3 0.083 11.0 0.3 2.0 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Peroxin-13_N PF04088.8 EFW98426.1 - 5.6e-57 192.1 0.0 9.8e-57 191.3 0.0 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.12 EFW98426.1 - 7.9e-08 31.6 0.0 1.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EFW98426.1 - 1.8e-07 30.6 0.3 2.7e-06 26.8 0.2 2.2 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFW98426.1 - 5e-06 25.8 0.2 0.00017 20.9 0.2 2.2 1 1 0 1 1 1 1 SH3 domain CENP-T PF15511.1 EFW98428.1 - 7.7e-120 400.9 12.0 1.2e-119 400.2 8.3 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T CENP-S PF15630.1 EFW98428.1 - 1.3e-11 44.4 0.0 2.3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Kinetochore component CENP-S Histone PF00125.19 EFW98428.1 - 0.00015 21.8 0.0 0.00044 20.3 0.0 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFW98428.1 - 0.051 13.6 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-CSL PF05207.8 EFW98431.1 - 0.14 11.6 2.0 0.21 11.1 0.2 2.0 2 0 0 2 2 2 0 CSL zinc finger GFA PF04828.9 EFW98431.1 - 4.7 7.2 9.6 0.081 12.8 1.4 2.0 2 1 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Cys_Met_Meta_PP PF01053.15 EFW98432.1 - 2.6e-152 506.6 0.0 2.9e-152 506.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EFW98432.1 - 4.6e-14 52.2 0.2 7.7e-14 51.5 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 EFW98432.1 - 7.9e-11 41.5 0.0 2.3e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFW98432.1 - 1.8e-08 33.5 0.5 7.1e-08 31.5 0.1 2.0 2 1 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFW98432.1 - 7.9e-08 31.7 0.0 1.3e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.11 EFW98432.1 - 0.0015 17.2 0.0 0.0023 16.6 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.6 EFW98432.1 - 0.0042 15.4 0.0 0.0055 15.0 0.0 1.1 1 0 0 1 1 1 1 Methionine gamma-lyase Radical_SAM PF04055.16 EFW98432.1 - 0.14 12.3 0.1 2.6 8.1 0.0 2.5 2 1 1 3 3 3 0 Radical SAM superfamily Pyridoxal_deC PF00282.14 EFW98433.1 - 6.9e-15 54.3 0.0 1.6e-14 53.1 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 EFW98433.1 - 3.1e-07 29.4 0.0 4.7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFW98433.1 - 8.3e-06 25.0 0.0 1.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Mito_carr PF00153.22 EFW98434.1 - 5.7e-44 147.7 7.1 5.4e-16 58.0 0.0 3.8 2 1 1 3 3 3 3 Mitochondrial carrier protein NOT2_3_5 PF04153.13 EFW98435.1 - 3.5e-31 107.8 0.5 5.5e-31 107.2 0.4 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family JmjC PF02373.17 EFW98437.1 - 1.6e-10 41.2 0.0 4.1e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.4 EFW98437.1 - 0.00033 20.7 8.7 0.00033 20.7 6.0 2.4 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.6 EFW98437.1 - 0.02 14.3 0.0 0.083 12.3 0.0 2.0 2 0 0 2 2 2 0 Cupin domain API5 PF05918.6 EFW98437.1 - 9.8 4.5 10.1 14 3.9 7.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) AAA PF00004.24 EFW98438.1 - 1.6e-77 258.1 0.0 7.7e-45 152.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFW98438.1 - 1.7e-17 63.3 0.0 3.4e-10 39.3 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFW98438.1 - 3e-12 46.7 0.1 0.0026 17.9 0.0 4.7 3 2 0 3 3 3 2 AAA domain AAA_16 PF13191.1 EFW98438.1 - 2.6e-11 43.8 5.6 8.5e-05 22.6 0.0 4.3 4 2 0 4 4 3 2 AAA ATPase domain AAA_14 PF13173.1 EFW98438.1 - 2.3e-09 37.2 0.0 0.0013 18.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EFW98438.1 - 2.3e-09 37.0 0.3 0.00046 19.9 0.0 3.6 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EFW98438.1 - 3.8e-09 36.5 2.5 0.00099 18.9 0.0 3.7 3 2 0 3 3 2 2 AAA domain AAA_17 PF13207.1 EFW98438.1 - 4.5e-08 33.9 0.0 0.023 15.5 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EFW98438.1 - 8.4e-08 31.8 0.3 0.0083 15.8 0.1 3.6 3 1 0 3 3 3 2 Part of AAA domain AAA_2 PF07724.9 EFW98438.1 - 2e-07 31.1 0.0 0.0018 18.2 0.0 3.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 EFW98438.1 - 2.9e-07 30.0 0.0 0.0079 15.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.17 EFW98438.1 - 8.3e-07 29.1 0.0 0.034 14.3 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.7 EFW98438.1 - 1.8e-06 27.2 0.1 0.0087 15.1 0.0 2.7 3 0 0 3 3 3 2 Zeta toxin Sigma54_activ_2 PF14532.1 EFW98438.1 - 2.2e-06 27.7 0.0 0.063 13.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.22 EFW98438.1 - 2.3e-06 27.9 0.4 0.014 15.7 0.1 3.3 3 1 0 3 3 3 2 ABC transporter Mg_chelatase PF01078.16 EFW98438.1 - 5.1e-06 25.7 0.0 0.057 12.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 EFW98438.1 - 6.1e-06 25.7 5.5 0.39 10.0 0.0 4.6 2 2 2 4 4 4 1 AAA domain Sigma54_activat PF00158.21 EFW98438.1 - 6.3e-06 25.7 0.0 0.031 13.7 0.0 2.8 3 0 0 3 3 2 2 Sigma-54 interaction domain TIP49 PF06068.8 EFW98438.1 - 6.7e-06 25.0 0.1 0.094 11.4 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus NB-ARC PF00931.17 EFW98438.1 - 7e-06 25.1 0.1 0.93 8.2 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain AAA_28 PF13521.1 EFW98438.1 - 8e-06 25.9 0.0 0.21 11.5 0.0 3.1 2 1 0 2 2 2 2 AAA domain DUF815 PF05673.8 EFW98438.1 - 1.4e-05 24.1 0.0 0.18 10.6 0.0 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF815) AAA_18 PF13238.1 EFW98438.1 - 3.4e-05 24.1 0.0 0.29 11.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 EFW98438.1 - 3.5e-05 23.0 0.0 0.02 13.9 0.0 2.6 2 0 0 2 2 2 1 KaiC NACHT PF05729.7 EFW98438.1 - 5.4e-05 22.9 0.6 1.3 8.6 0.1 4.0 3 1 0 3 3 3 1 NACHT domain ATP-synt_ab PF00006.20 EFW98438.1 - 5.8e-05 22.6 0.1 0.31 10.5 0.0 2.6 3 0 0 3 3 2 2 ATP synthase alpha/beta family, nucleotide-binding domain Arch_ATPase PF01637.13 EFW98438.1 - 0.00015 21.5 0.0 0.21 11.2 0.0 3.2 2 2 1 3 3 3 1 Archaeal ATPase Rad17 PF03215.10 EFW98438.1 - 0.00028 19.6 0.0 0.29 9.7 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_24 PF13479.1 EFW98438.1 - 0.00045 19.8 0.1 0.38 10.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain PhoH PF02562.11 EFW98438.1 - 0.00045 19.5 0.6 0.16 11.2 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.10 EFW98438.1 - 0.0005 19.9 0.0 0.98 9.2 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Bac_DnaA PF00308.13 EFW98438.1 - 0.002 17.8 0.1 1.5 8.4 0.1 3.3 2 1 0 2 2 2 1 Bacterial dnaA protein SKI PF01202.17 EFW98438.1 - 0.0021 17.9 0.0 0.87 9.4 0.0 2.7 2 0 0 2 2 2 1 Shikimate kinase AAA_11 PF13086.1 EFW98438.1 - 0.0046 16.5 0.0 5.4 6.5 0.0 2.9 3 1 0 3 3 3 0 AAA domain Parvo_NS1 PF01057.12 EFW98438.1 - 0.0047 15.8 0.1 2 7.2 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_3 PF07726.6 EFW98438.1 - 0.013 15.1 0.0 2.1 7.9 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EFW98438.1 - 0.023 14.5 0.1 0.12 12.2 0.0 2.2 2 0 0 2 2 1 0 Vps4 C terminal oligomerisation domain NTPase_1 PF03266.10 EFW98438.1 - 0.024 14.3 0.0 5.6 6.6 0.0 2.8 2 0 0 2 2 2 0 NTPase DUF258 PF03193.11 EFW98438.1 - 0.033 13.3 0.0 0.18 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_PrkA PF08298.6 EFW98438.1 - 0.035 12.8 0.0 0.1 11.3 0.0 1.6 2 0 0 2 2 2 0 PrkA AAA domain AAA_10 PF12846.2 EFW98438.1 - 0.044 13.2 0.4 3.3 7.0 0.0 3.3 2 2 0 3 3 3 0 AAA-like domain AAA_23 PF13476.1 EFW98438.1 - 0.046 14.0 0.1 0.52 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.5 EFW98438.1 - 0.047 12.9 0.0 4.8 6.3 0.0 2.9 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit LcrG PF07216.7 EFW98438.1 - 0.058 13.4 3.7 7.2 6.7 0.0 3.6 3 0 0 3 3 3 0 LcrG protein DEAD PF00270.24 EFW98438.1 - 0.068 12.6 0.2 1.1 8.7 0.0 2.6 3 0 0 3 3 2 0 DEAD/DEAH box helicase DUF2075 PF09848.4 EFW98438.1 - 0.081 11.8 0.0 9 5.1 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UPF0079 PF02367.12 EFW98438.1 - 0.088 12.4 0.0 9.5 5.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 IPT PF01745.11 EFW98438.1 - 0.12 11.4 0.2 14 4.7 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase PduV-EutP PF10662.4 EFW98438.1 - 0.13 11.6 0.0 9.1 5.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Methyltransf_11 PF08241.7 EFW98439.1 - 7.2e-09 36.0 0.0 1.3e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW98439.1 - 2.5e-08 34.4 0.0 5.2e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFW98439.1 - 1e-07 31.8 0.0 1.5e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW98439.1 - 1.4e-05 25.0 0.1 3.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW98439.1 - 1.7e-05 25.2 0.0 3.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW98439.1 - 0.00097 18.7 0.0 0.0028 17.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW98439.1 - 0.0024 18.2 0.0 0.0046 17.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFW98439.1 - 0.014 14.5 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DREV PF05219.7 EFW98439.1 - 0.2 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Cyclin PF08613.6 EFW98440.1 - 3.8e-28 98.7 0.0 7.2e-28 97.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EFW98440.1 - 1.7e-05 24.3 0.0 2.9e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ndc1_Nup PF09531.5 EFW98440.1 - 1.3 7.4 2.9 1.7 6.9 2.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.4 EFW98440.1 - 7.9 4.5 31.2 11 4.1 21.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HTH_Tnp_1 PF01527.15 EFW98441.1 - 0.057 13.3 2.7 0.2 11.6 0.0 2.9 3 0 0 3 3 3 0 Transposase DUF3885 PF13021.1 EFW98441.1 - 0.061 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) Biotin_carb_C PF02785.14 EFW98441.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain DUF1771 PF08590.5 EFW98442.1 - 2e-24 85.3 8.3 5.8e-24 83.8 5.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.16 EFW98442.1 - 4.1e-16 58.9 0.4 4.1e-16 58.9 0.3 2.1 2 0 0 2 2 2 1 Smr domain Zip PF02535.17 EFW98442.1 - 0.32 9.9 1.8 0.36 9.7 1.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Nfu_N PF08712.6 EFW98443.1 - 3.5e-26 90.6 0.0 7.9e-26 89.5 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 EFW98443.1 - 3.7e-22 77.8 0.1 6.7e-22 77.0 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Zn_clus PF00172.13 EFW98445.1 - 8.8e-10 38.3 9.0 8.8e-10 38.3 6.3 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.2 EFW98446.1 - 0.01 15.5 0.1 0.022 14.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like VEFS-Box PF09733.4 EFW98447.1 - 1.2e-09 37.9 0.3 1.2e-09 37.9 0.2 1.6 2 0 0 2 2 2 1 VEFS-Box of polycomb protein ATP-synt_C PF00137.16 EFW98448.1 - 2.2e-26 91.5 28.6 2.9e-15 55.8 5.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Zn_clus PF00172.13 EFW98449.1 - 2.3e-05 24.2 8.0 3.9e-05 23.4 5.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TerY-C PF15616.1 EFW98449.1 - 0.41 10.5 3.6 0.94 9.4 2.5 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain DUF1961 PF09224.6 EFW98450.1 - 1.6e-82 275.8 0.0 1.8e-82 275.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) SKG6 PF08693.5 EFW98451.1 - 2.6e-10 39.4 1.2 8.7e-10 37.7 0.8 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CcmD PF04995.9 EFW98451.1 - 0.0099 15.5 2.0 0.02 14.6 1.4 1.4 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) Rax2 PF12768.2 EFW98451.1 - 0.026 13.7 0.1 0.044 13.0 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity EphA2_TM PF14575.1 EFW98451.1 - 0.099 13.0 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rifin_STEVOR PF02009.11 EFW98451.1 - 0.46 10.0 0.0 0.46 10.0 0.0 2.9 1 1 2 3 3 3 0 Rifin/stevor family BTB PF00651.26 EFW98453.1 - 0.0003 20.7 0.0 0.00049 20.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF834 PF05754.9 EFW98453.1 - 0.044 13.5 2.6 0.15 11.9 1.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF834) DUF4066 PF13278.1 EFW98454.1 - 3.4e-22 78.4 0.0 2.5e-19 69.1 0.0 2.0 2 0 0 2 2 2 2 Putative amidotransferase DJ-1_PfpI PF01965.19 EFW98454.1 - 0.0029 17.0 0.0 0.0079 15.6 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family CENP-H PF05837.7 EFW98455.1 - 5.3e-21 74.7 2.7 3.4e-20 72.1 0.5 2.1 2 0 0 2 2 2 1 Centromere protein H (CENP-H) FAM176 PF14851.1 EFW98455.1 - 0.11 12.1 1.0 3.5 7.3 0.1 2.2 2 0 0 2 2 2 0 FAM176 family THP2 PF09432.5 EFW98455.1 - 0.17 11.7 1.2 0.34 10.7 0.1 1.8 2 0 0 2 2 2 0 Tho complex subunit THP2 DUF2721 PF11026.3 EFW98455.1 - 0.31 10.6 2.0 14 5.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) PBP1_TM PF14812.1 EFW98455.1 - 5.9 7.2 10.1 12 6.3 0.8 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TPR_11 PF13414.1 EFW98456.1 - 1.5e-12 46.9 6.2 1e-09 37.9 0.8 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFW98456.1 - 4.5e-07 29.2 9.7 0.0053 16.5 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFW98456.1 - 5.1e-07 29.5 3.7 0.00085 19.2 1.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFW98456.1 - 4.4e-05 22.9 5.4 0.052 13.1 0.7 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFW98456.1 - 0.002 17.7 2.2 0.062 13.0 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFW98456.1 - 0.015 15.7 2.6 0.85 10.2 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFW98456.1 - 0.018 15.7 8.2 0.26 12.0 3.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 EFW98456.1 - 0.057 13.2 1.6 0.21 11.4 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFW98456.1 - 0.26 12.0 3.7 59 4.7 1.8 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Pyr_redox_3 PF13738.1 EFW98457.1 - 9.6e-21 74.7 0.0 7e-20 71.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFW98457.1 - 1.9e-10 39.5 0.1 1.2e-09 37.0 0.0 2.0 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFW98457.1 - 1.8e-07 30.4 0.1 0.0011 18.0 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFW98457.1 - 2.8e-07 30.4 0.0 7.4e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFW98457.1 - 6.4e-07 29.2 1.5 0.00013 21.7 0.0 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.19 EFW98457.1 - 0.0013 17.7 0.3 0.043 12.7 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFW98457.1 - 0.002 18.0 0.3 1.3 8.8 0.2 2.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFW98457.1 - 0.0023 18.3 0.4 16 5.9 0.0 3.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFW98457.1 - 0.0046 16.0 0.2 0.089 11.8 0.0 2.2 2 0 0 2 2 2 1 Thi4 family IlvN PF07991.7 EFW98457.1 - 0.013 14.9 0.6 0.62 9.4 0.0 2.4 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Malic_M PF03949.10 EFW98457.1 - 0.017 14.7 0.1 1 8.8 0.0 2.2 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain HI0933_like PF03486.9 EFW98457.1 - 0.2 10.1 0.4 0.72 8.2 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein 2-Hacid_dh_C PF02826.14 EFW98457.1 - 0.21 10.7 0.1 0.78 8.8 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_hydro_3 PF00933.16 EFW98458.1 - 5e-45 153.7 0.0 6.6e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFW98458.1 - 1.7e-10 40.8 0.4 1.6e-08 34.3 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain ADH_zinc_N_2 PF13602.1 EFW98458.1 - 1.9e-08 35.2 0.0 6.3e-08 33.5 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFW98458.1 - 3.5e-05 23.3 0.0 9.6e-05 21.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Cofilin_ADF PF00241.15 EFW98459.1 - 3.7e-33 114.1 0.1 4.4e-33 113.8 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PP2C PF00481.16 EFW98460.1 - 3.9e-40 137.8 0.0 7.2e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Glyco_hydro_63 PF03200.11 EFW98460.1 - 8.2e-07 27.2 2.8 4.1e-05 21.6 0.1 2.8 2 1 0 2 2 2 2 Mannosyl oligosaccharide glucosidase PP2C_2 PF13672.1 EFW98460.1 - 0.0043 16.4 0.6 0.021 14.2 0.1 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.7 EFW98460.1 - 0.0096 15.6 0.1 0.23 11.1 0.0 2.7 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) COesterase PF00135.23 EFW98461.1 - 1.5e-62 212.0 0.0 2e-62 211.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFW98461.1 - 9.7e-07 28.5 0.3 0.00066 19.3 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_C97 PF05903.9 EFW98463.1 - 4.5e-31 107.6 0.0 5.7e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 EFW98463.1 - 0.0016 18.3 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Sds3 PF08598.6 EFW98464.1 - 3e-27 95.4 0.3 3e-27 95.4 0.2 4.9 3 2 0 3 3 3 1 Sds3-like Med15 PF09606.5 EFW98464.1 - 0.061 11.5 47.7 0.1 10.8 33.1 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal tRNA-synt_1e PF01406.14 EFW98465.1 - 8.2e-115 383.0 0.0 1.2e-114 382.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 EFW98465.1 - 9.8e-07 27.7 0.3 0.035 12.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.13 EFW98465.1 - 0.0044 15.7 0.1 0.99 8.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.17 EFW98465.1 - 0.069 11.1 0.0 1.4 6.8 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (I, L, M and V) DLIC PF05783.6 EFW98466.1 - 0.83 8.2 3.0 1.9 7.0 2.0 1.5 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Sds3 PF08598.6 EFW98467.1 - 5.3e-47 160.0 3.2 2.3e-46 157.9 2.2 2.0 1 1 0 1 1 1 1 Sds3-like FMN_bind PF04205.9 EFW98467.1 - 0.034 14.3 0.2 0.17 12.0 0.0 2.3 2 1 0 2 2 2 0 FMN-binding domain Transcrip_reg PF01709.15 EFW98469.1 - 4.9e-50 169.8 0.0 6.3e-50 169.4 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator NAD_binding_8 PF13450.1 EFW98470.1 - 4.1e-10 39.5 0.1 8.5e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFW98470.1 - 2.7e-07 30.0 0.0 5.2e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.1 EFW98470.1 - 6.2e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFW98470.1 - 0.0045 16.8 0.0 0.021 14.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFW98470.1 - 0.012 14.7 0.1 0.022 13.8 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 EFW98470.1 - 0.031 14.0 0.2 1.1 9.0 0.0 2.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.9 EFW98470.1 - 0.034 12.6 0.1 0.05 12.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.2 EFW98470.1 - 0.042 12.9 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase TrkA_N PF02254.13 EFW98470.1 - 0.05 13.5 0.0 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain DAO PF01266.19 EFW98470.1 - 0.055 12.3 0.0 0.12 11.2 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFW98470.1 - 0.085 11.6 0.2 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.12 EFW98470.1 - 0.091 11.8 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.7 EFW98470.1 - 0.13 11.1 0.3 0.25 10.2 0.2 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Fungal_trans PF04082.13 EFW98471.1 - 2.1e-14 53.0 0.1 4.6e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW98471.1 - 0.00047 20.0 5.5 0.0011 18.8 3.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP_bind_3 PF01171.15 EFW98472.1 - 3.5e-36 124.4 0.0 3.1e-25 88.7 0.0 2.2 2 0 0 2 2 2 2 PP-loop family Arf PF00025.16 EFW98474.1 - 3.9e-74 247.6 0.0 4.7e-74 247.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFW98474.1 - 2e-14 53.2 0.0 2.4e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 EFW98474.1 - 6.1e-12 44.9 0.5 4.3e-08 32.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 EFW98474.1 - 1.1e-11 44.3 0.0 1.3e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFW98474.1 - 2.1e-09 37.9 0.0 2.9e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 EFW98474.1 - 2.2e-09 36.8 0.0 2.5e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFW98474.1 - 1.1e-06 28.5 0.0 1.6e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFW98474.1 - 2.2e-06 27.2 0.0 0.00033 20.1 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 EFW98474.1 - 0.0066 15.7 0.9 0.032 13.5 0.6 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B ArgK PF03308.11 EFW98474.1 - 0.0067 15.2 0.3 0.054 12.2 0.1 2.3 2 1 0 2 2 2 1 ArgK protein DUF3986 PF13143.1 EFW98474.1 - 0.087 13.2 0.2 0.25 11.8 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3986) WD40 PF00400.27 EFW98475.1 - 8.8e-13 47.6 16.0 0.00093 18.9 0.1 7.5 9 0 0 9 9 9 3 WD domain, G-beta repeat DUF4175 PF13779.1 EFW98475.1 - 6.5 4.3 31.9 0.12 10.1 16.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Ycf1 PF05758.7 EFW98475.1 - 8.9 3.8 10.1 13 3.3 7.0 1.1 1 0 0 1 1 1 0 Ycf1 Peptidase_C14 PF00656.17 EFW98477.1 - 9.4e-68 228.5 0.0 1.3e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Mito_carr PF00153.22 EFW98478.1 - 8.5e-60 198.4 1.0 1.7e-20 72.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_26 PF13659.1 EFW98478.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain NUDIX PF00293.23 EFW98479.1 - 1.2e-28 99.4 0.0 1.7e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain AAA_6 PF12774.2 EFW98479.1 - 0.072 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region D1 cobW PF02492.14 EFW98480.1 - 1.3e-44 151.7 0.1 1.7e-44 151.3 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EFW98480.1 - 9.2e-06 25.2 0.0 1.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_19 PF13245.1 EFW98480.1 - 0.0047 16.6 0.2 0.016 14.9 0.1 1.9 1 1 0 1 1 1 1 Part of AAA domain ATP_bind_1 PF03029.12 EFW98480.1 - 0.0061 16.1 0.1 0.38 10.2 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 EFW98480.1 - 0.0087 14.8 1.2 1.2 7.8 0.0 2.7 3 0 0 3 3 3 1 ArgK protein GTP_EFTU PF00009.22 EFW98480.1 - 0.021 14.2 0.0 6 6.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 EFW98480.1 - 0.023 14.7 0.0 0.079 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Arch_ATPase PF01637.13 EFW98480.1 - 0.024 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_23 PF13476.1 EFW98480.1 - 0.036 14.3 0.1 0.061 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFW98480.1 - 0.04 14.0 0.2 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EFW98480.1 - 0.04 13.3 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 EFW98480.1 - 0.055 12.9 0.1 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFW98480.1 - 0.058 13.7 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EFW98480.1 - 0.071 12.1 0.0 0.21 10.6 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.18 EFW98480.1 - 0.073 13.0 0.5 0.16 11.9 0.4 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Miro PF08477.8 EFW98480.1 - 0.092 13.2 0.2 0.59 10.6 0.0 2.3 3 0 0 3 3 2 0 Miro-like protein DUF258 PF03193.11 EFW98480.1 - 0.11 11.6 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MobB PF03205.9 EFW98480.1 - 0.11 12.1 0.1 0.22 11.2 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 EFW98480.1 - 0.11 12.3 0.0 0.37 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 EFW98480.1 - 0.15 11.6 0.9 1.5 8.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EFW98480.1 - 0.16 10.8 1.2 0.2 10.4 0.1 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Zn_clus PF00172.13 EFW98481.1 - 2.2e-06 27.4 12.2 3.4e-06 26.8 8.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RibD_C PF01872.12 EFW98482.1 - 4.5e-33 114.5 0.0 5.3e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain DUF382 PF04037.8 EFW98483.1 - 7.9e-62 206.8 0.2 1.9e-61 205.5 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.11 EFW98483.1 - 2.8e-20 71.4 6.3 6e-20 70.3 4.4 1.6 1 0 0 1 1 1 1 PSP tRNA-synt_1 PF00133.17 EFW98484.1 - 5e-149 497.0 0.0 6.4e-149 496.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EFW98484.1 - 4.8e-21 74.8 0.0 4e-12 45.5 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EFW98484.1 - 2.2e-15 56.7 0.0 3.6e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.9 EFW98484.1 - 2e-06 27.2 3.3 3.6e-06 26.4 2.3 1.5 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.14 EFW98484.1 - 0.065 12.3 0.0 1.8 7.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.1 EFW98484.1 - 0.18 11.1 0.0 0.78 9.0 0.0 1.9 2 0 0 2 2 2 0 Leucyl-tRNA synthetase, Domain 2 TIG PF01833.19 EFW98486.1 - 1.7e-13 50.3 0.4 6.3e-13 48.5 0.3 2.0 1 0 0 1 1 1 1 IPT/TIG domain Ank PF00023.25 EFW98486.1 - 5.6e-13 47.9 2.8 3.2e-08 32.9 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 EFW98486.1 - 1.5e-11 44.4 0.0 3.9e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFW98486.1 - 4.5e-11 42.6 1.6 9.2e-11 41.6 0.3 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFW98486.1 - 1.7e-06 28.3 0.3 6.3e-05 23.3 0.2 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98486.1 - 4.2e-06 26.4 0.4 0.0026 17.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Cytochrom_C PF00034.16 EFW98487.1 - 9.1e-10 39.2 0.0 1.3e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 EFW98487.1 - 3e-09 36.8 2.0 1.9e-08 34.3 1.4 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 EFW98487.1 - 0.019 14.4 2.6 0.034 13.6 0.4 2.2 1 1 2 3 3 3 0 Cytochrome c-550 domain AAA PF00004.24 EFW98488.1 - 6.9e-36 123.3 0.1 1e-33 116.3 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) BSD PF03909.12 EFW98488.1 - 6e-25 86.7 2.8 1e-14 53.9 0.1 2.7 2 0 0 2 2 2 2 BSD domain TFIIH_BTF_p62_N PF08567.6 EFW98488.1 - 4.8e-19 67.7 0.0 1.1e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain AAA_22 PF13401.1 EFW98488.1 - 1.1e-06 28.7 1.6 0.0079 16.3 0.1 4.3 3 1 0 3 3 3 1 AAA domain AAA_14 PF13173.1 EFW98488.1 - 5e-05 23.2 0.0 0.019 14.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFW98488.1 - 0.0002 21.4 4.8 0.0036 17.3 0.0 4.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 EFW98488.1 - 0.00029 21.6 0.3 0.0025 18.6 0.0 3.0 3 1 0 3 3 1 1 AAA domain IstB_IS21 PF01695.12 EFW98488.1 - 0.00051 19.5 0.0 0.0016 17.8 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 EFW98488.1 - 0.0013 18.6 0.2 0.023 14.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.7 EFW98488.1 - 0.002 17.2 0.0 0.0041 16.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFW98488.1 - 0.0077 15.9 2.3 0.031 14.0 0.4 2.8 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 EFW98488.1 - 0.0083 16.0 0.1 0.11 12.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFW98488.1 - 0.015 15.6 0.0 0.068 13.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFW98488.1 - 0.02 14.0 0.2 0.17 10.9 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 EFW98488.1 - 0.03 13.8 0.0 4.5 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EFW98488.1 - 0.047 13.4 0.1 0.14 11.9 0.1 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 EFW98488.1 - 0.13 12.3 0.0 0.49 10.4 0.0 2.0 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.17 EFW98488.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.21 EFW98488.1 - 0.16 11.4 0.1 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 EFW98488.1 - 0.29 10.7 0.4 23 4.6 0.0 3.1 3 1 0 3 3 3 0 Archaeal ATPase TIP49 PF06068.8 EFW98488.1 - 0.8 8.3 1.8 0.6 8.7 0.0 1.6 2 0 0 2 2 2 0 TIP49 C-terminus Ras PF00071.17 EFW98489.1 - 3.5e-56 189.0 0.0 4e-56 188.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFW98489.1 - 8.9e-16 58.4 0.0 1.3e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFW98489.1 - 1.4e-07 30.9 0.0 2.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFW98489.1 - 0.0004 19.6 0.0 0.00057 19.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 EFW98489.1 - 0.037 13.1 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EFW98489.1 - 0.11 12.0 0.0 11 5.4 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ALIX_LYPXL_bnd PF13949.1 EFW98489.1 - 0.13 11.2 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV IBR PF01485.16 EFW98492.1 - 3.3e-12 46.0 26.1 4e-11 42.6 5.1 3.8 3 1 0 3 3 3 2 IBR domain zf-C3HC4_2 PF13923.1 EFW98492.1 - 0.0064 16.5 5.9 0.0064 16.5 4.1 3.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFW98492.1 - 0.0073 16.1 5.2 0.0073 16.1 3.6 3.3 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 EFW98492.1 - 0.017 14.8 4.7 0.017 14.8 3.3 3.8 2 1 1 3 3 3 0 zinc-RING finger domain zf-RING_4 PF14570.1 EFW98492.1 - 2.1 8.0 19.8 0.93 9.1 3.0 3.5 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain adh_short PF00106.20 EFW98493.1 - 2.3e-19 69.9 1.6 2.3e-19 69.9 1.1 1.8 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW98493.1 - 3.6e-09 36.7 0.1 8.3e-09 35.5 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFW98493.1 - 0.031 14.2 0.5 0.4 10.6 0.0 2.3 2 0 0 2 2 2 0 NADH(P)-binding Epimerase PF01370.16 EFW98493.1 - 0.092 12.1 0.2 0.18 11.2 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GFA PF04828.9 EFW98494.1 - 6e-14 51.7 2.2 7.1e-07 29.0 2.7 2.9 2 1 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme zf-dskA_traR PF01258.12 EFW98494.1 - 5.2 6.9 10.2 2 8.2 0.0 2.9 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger RPE65 PF03055.10 EFW98495.1 - 5.7e-121 404.4 0.0 6.4e-121 404.2 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein HSP70 PF00012.15 EFW98496.1 - 2.4e-08 32.3 0.1 1.1e-06 26.8 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein DUF2439 PF10382.4 EFW98496.1 - 0.092 12.9 0.1 2.3 8.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) DUF1183 PF06682.7 EFW98496.1 - 6.3 6.3 7.4 0.31 10.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) Kinesin PF00225.18 EFW98497.1 - 1.9e-97 325.9 1.0 3.7e-97 325.0 0.7 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bind PF13931.1 EFW98497.1 - 0.00037 20.6 0.0 0.00037 20.6 0.0 3.2 3 0 0 3 3 3 1 Kinesin-associated microtubule-binding Rer1 PF03248.8 EFW98499.1 - 1.6e-82 275.3 4.4 1.8e-82 275.1 3.1 1.0 1 0 0 1 1 1 1 Rer1 family Ndc1_Nup PF09531.5 EFW98499.1 - 5.4 5.3 10.8 12 4.1 7.5 1.5 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GSIII_N PF12437.3 EFW98500.1 - 0.11 11.8 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal Spt20 PF12090.3 EFW98500.1 - 0.67 9.2 5.1 1.2 8.4 3.5 1.4 1 0 0 1 1 1 0 Spt20 family Het-C PF07217.6 EFW98501.1 - 1.3e-262 872.4 0.0 1.8e-262 871.9 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C AATase PF07247.7 EFW98502.1 - 9.5e-11 40.9 0.0 3.6e-10 39.0 0.0 1.7 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 EFW98502.1 - 6.5e-07 28.4 0.0 2.8e-05 23.1 0.0 2.1 2 0 0 2 2 2 2 Condensation domain SPRY PF00622.23 EFW98503.1 - 0.04 14.0 0.0 0.31 11.1 0.0 2.2 2 1 0 2 2 2 0 SPRY domain MARVEL PF01284.18 EFW98504.1 - 1.1e-21 77.1 21.3 1.4e-21 76.8 14.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain cwf21 PF08312.7 EFW98505.1 - 8.2e-15 54.3 5.9 8.2e-15 54.3 4.1 2.3 2 0 0 2 2 2 1 cwf21 domain GvpG PF05120.7 EFW98505.1 - 0.83 9.4 6.4 3.4 7.5 0.0 2.6 2 1 0 2 2 2 0 Gas vesicle protein G DUF4210 PF13915.1 EFW98506.1 - 5e-25 87.5 1.2 7.9e-25 86.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.1 EFW98506.1 - 1.6e-21 75.9 1.4 3e-21 75.0 0.9 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis p450 PF00067.17 EFW98507.1 - 4.7e-45 153.9 0.0 5.8e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lact_bio_phlase PF09508.5 EFW98507.1 - 0.18 9.4 0.0 0.27 8.8 0.0 1.1 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase GWT1 PF06423.7 EFW98508.1 - 6e-38 130.0 0.0 1.6e-37 128.6 0.0 1.8 1 0 0 1 1 1 1 GWT1 AMP-binding PF00501.23 EFW98509.1 - 2.4e-79 266.6 0.0 3.3e-79 266.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FSH1 PF03959.8 EFW98510.1 - 3.7e-29 101.7 0.0 1.4e-28 99.7 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 EFW98510.1 - 3.9e-07 30.1 3.5 0.0084 16.0 0.1 2.6 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFW98510.1 - 5.2e-06 26.2 0.0 1.4e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFW98510.1 - 1e-05 25.0 0.3 0.0025 17.2 0.2 3.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase PE-PPE PF08237.6 EFW98510.1 - 0.048 13.0 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain MerC PF03203.9 EFW98511.1 - 1.5 9.1 6.7 2.5 8.5 2.6 2.4 2 1 0 2 2 2 0 MerC mercury resistance protein DUF3285 PF11688.3 EFW98511.1 - 8.8 6.0 6.2 39 3.9 0.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) Sec1 PF00995.18 EFW98512.1 - 4.7e-135 451.3 0.0 5.7e-135 451.1 0.0 1.1 1 0 0 1 1 1 1 Sec1 family MatE PF01554.13 EFW98512.1 - 1.6e-52 177.4 26.6 1.4e-26 93.0 6.4 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 EFW98512.1 - 2.1e-08 34.0 12.1 1.9e-05 24.5 3.0 2.8 2 0 0 2 2 2 2 Polysaccharide biosynthesis C-terminal domain Apo-CIII PF05778.7 EFW98512.1 - 0.11 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) Cu_bind_like PF02298.12 EFW98513.1 - 0.029 14.1 0.2 0.22 11.3 0.2 2.2 1 1 0 1 1 1 0 Plastocyanin-like domain DAO PF01266.19 EFW98514.1 - 1.1e-49 169.2 6.9 1.3e-49 169.0 4.8 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFW98514.1 - 8.9e-06 25.8 0.8 0.00052 20.1 0.5 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFW98514.1 - 0.0033 17.3 0.8 0.0076 16.2 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFW98514.1 - 0.0036 17.2 0.3 0.0082 16.0 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFW98514.1 - 0.0051 15.7 5.4 0.013 14.3 2.1 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 EFW98514.1 - 0.0067 15.5 0.1 0.012 14.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 EFW98514.1 - 0.034 13.9 0.8 0.33 10.7 0.2 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.17 EFW98514.1 - 0.69 8.6 3.0 1 8.1 2.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Glyco_transf_90 PF05686.7 EFW98516.1 - 1.5e-14 53.4 8.6 1.5e-10 40.3 5.6 3.0 2 1 0 2 2 2 2 Glycosyl transferase family 90 Kelch_4 PF13418.1 EFW98517.1 - 8.8e-28 95.8 8.0 7.9e-09 35.1 0.0 6.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 EFW98517.1 - 5.2e-24 83.3 3.8 5.8e-05 23.0 0.0 5.6 4 1 1 5 5 5 4 Kelch motif Kelch_5 PF13854.1 EFW98517.1 - 6e-22 77.1 6.7 1e-05 25.3 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 EFW98517.1 - 2e-21 75.2 0.4 6.1e-05 22.4 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.1 EFW98517.1 - 7.2e-19 67.4 10.2 1.2e-07 31.6 0.0 6.1 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 EFW98517.1 - 8.8e-18 63.3 5.2 0.0001 21.9 0.0 5.3 5 0 0 5 5 5 4 Kelch motif BTB PF00651.26 EFW98517.1 - 2.6e-07 30.6 0.0 1.8e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 EFW98517.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch zf-RING_6 PF14835.1 EFW98518.1 - 0.047 13.4 4.6 0.074 12.8 3.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 EFW98518.1 - 0.88 9.2 8.1 1.4 8.6 5.6 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3984 PF13136.1 EFW98519.1 - 6e-44 150.5 28.3 6e-44 150.5 19.6 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3984) Nucleoplasmin PF03066.10 EFW98519.1 - 0.051 13.1 6.9 0.085 12.3 4.8 1.4 1 0 0 1 1 1 0 Nucleoplasmin Nop14 PF04147.7 EFW98519.1 - 0.16 9.8 10.2 0.22 9.3 7.1 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 EFW98519.1 - 0.5 8.3 6.2 0.73 7.7 4.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.4 EFW98519.1 - 0.6 8.7 26.7 0.0094 14.7 13.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.7 EFW98519.1 - 1 8.9 8.1 1.8 8.1 5.6 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.7 EFW98519.1 - 9.7 5.3 11.1 14 4.8 7.7 1.2 1 0 0 1 1 1 0 SDA1 TPT PF03151.11 EFW98520.1 - 1.3e-28 99.6 12.8 1.3e-28 99.6 8.8 2.6 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 EFW98520.1 - 0.081 12.9 38.1 0.099 12.6 9.9 2.8 3 0 0 3 3 3 0 EamA-like transporter family UAA PF08449.6 EFW98520.1 - 4.1 6.2 26.5 51 2.6 18.4 2.1 1 1 0 1 1 1 0 UAA transporter family DUF4452 PF14618.1 EFW98521.1 - 1.2e-42 145.4 10.2 1.5e-42 145.2 7.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) MFS_1 PF07690.11 EFW98522.1 - 1.9e-34 118.9 40.4 1.9e-34 118.9 28.0 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily adh_short PF00106.20 EFW98523.1 - 3.9e-24 85.4 3.6 4.1e-21 75.6 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EFW98523.1 - 7.8e-11 42.2 0.0 1e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFW98523.1 - 4.6e-08 32.9 3.3 1.5e-06 27.9 0.0 2.6 1 1 1 2 2 2 2 KR domain DUF1776 PF08643.5 EFW98523.1 - 0.076 12.1 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Amidohydro_1 PF01979.15 EFW98524.1 - 6.2e-58 197.0 2.1 2e-57 195.3 1.8 1.6 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.15 EFW98524.1 - 1.7e-48 163.7 0.3 4.1e-48 162.5 0.2 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.13 EFW98524.1 - 1.1e-39 134.3 0.0 3e-39 133.0 0.0 1.8 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.15 EFW98524.1 - 1.3e-39 134.0 0.3 3.5e-39 132.6 0.0 1.8 2 0 0 2 2 2 1 Urease beta subunit Amidohydro_5 PF13594.1 EFW98524.1 - 5.5e-08 32.5 1.5 1.6e-07 31.0 1.1 1.8 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_2 PF04909.9 EFW98524.1 - 0.0039 16.8 0.3 0.011 15.2 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 EFW98524.1 - 0.1 11.7 8.4 0.17 11.0 2.4 2.8 1 1 1 2 2 2 0 Amidohydrolase family RINGv PF12906.2 EFW98525.1 - 5.4e-07 29.5 5.9 5.4e-07 29.5 4.1 2.3 2 0 0 2 2 2 1 RING-variant domain Ribosomal_L27e PF01777.13 EFW98526.1 - 2.2e-37 127.0 4.6 2.8e-37 126.6 3.2 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 EFW98526.1 - 0.0029 17.2 2.4 0.0042 16.7 0.6 2.1 2 0 0 2 2 2 1 KOW motif DUF1922 PF09082.5 EFW98526.1 - 0.038 14.0 0.1 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) Tubulin PF00091.20 EFW98527.1 - 2e-62 210.8 0.0 2.7e-62 210.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFW98527.1 - 3.7e-43 146.5 0.0 5.5e-43 146.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 EFW98527.1 - 5.9e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain MFS_1 PF07690.11 EFW98529.1 - 2e-18 66.2 38.1 3.4e-14 52.3 11.0 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily Urb2 PF10441.4 EFW98531.1 - 2.1e-46 158.3 0.0 5.8e-46 156.8 0.0 1.8 2 0 0 2 2 2 1 Urb2/Npa2 family Cyclin_N PF00134.18 EFW98532.1 - 4e-12 45.8 0.1 1.9e-11 43.6 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.14 EFW98532.1 - 0.15 11.9 0.1 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Transcription factor TFIIB repeat MOSC_N PF03476.11 EFW98534.1 - 3.3e-08 33.2 0.0 8.5e-08 31.9 0.0 1.7 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 EFW98534.1 - 0.023 14.1 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 MOSC domain DUF4440 PF14534.1 EFW98534.1 - 0.035 14.3 0.5 0.098 12.8 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4440) RasGEF PF00617.14 EFW98535.1 - 2.8e-63 213.0 0.0 4.9e-63 212.2 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EFW98535.1 - 1.4e-26 92.5 0.4 3.8e-26 91.1 0.3 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.23 EFW98535.1 - 7.1e-16 57.3 0.1 1.4e-15 56.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFW98535.1 - 2.2e-14 52.7 0.2 4.6e-14 51.7 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFW98535.1 - 3.5e-13 48.8 0.1 8.2e-13 47.6 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.21 EFW98535.1 - 0.00013 21.7 0.0 0.00024 20.8 0.0 1.5 1 0 0 1 1 1 1 WW domain UDPGT PF00201.13 EFW98536.1 - 1.6e-14 53.3 0.0 2.2e-13 49.6 0.0 1.9 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.1 EFW98536.1 - 1.3e-05 24.5 0.0 4.5e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 EFW98536.1 - 0.22 11.1 0.0 0.37 10.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain MFS_1 PF07690.11 EFW98538.1 - 9.8e-35 119.8 88.3 1.3e-25 89.8 34.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 EFW98538.1 - 0.00043 20.0 5.2 0.016 14.9 0.4 3.3 4 0 0 4 4 4 2 MFS_1 like family DUF1129 PF06570.6 EFW98538.1 - 0.18 11.1 0.1 0.18 11.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Peptidase_S15 PF02129.13 EFW98538.1 - 0.23 10.8 0.1 0.35 10.2 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) CHD5 PF04420.9 EFW98539.1 - 9.3e-53 178.1 0.0 1.1e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 CHD5-like protein PcfJ PF14284.1 EFW98539.1 - 0.03 13.8 0.1 0.045 13.2 0.1 1.2 1 0 0 1 1 1 0 PcfJ-like protein DUF1515 PF07439.6 EFW98539.1 - 0.18 11.6 1.9 0.22 11.3 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) PS-DH PF14765.1 EFW98540.1 - 1e-51 175.8 0.5 2.5e-51 174.6 0.3 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 EFW98540.1 - 6e-42 144.0 2.5 5e-41 141.0 1.7 2.1 1 1 0 1 1 1 1 Acyl transferase domain Methyltransf_12 PF08242.7 EFW98540.1 - 5.5e-18 65.2 0.0 1.5e-17 63.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFW98540.1 - 8.2e-12 45.1 0.0 1.8e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW98540.1 - 1.1e-09 38.8 0.0 2.8e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain FAD_binding_4 PF01565.18 EFW98540.1 - 4.1e-09 36.0 0.1 4.1e-06 26.3 0.0 2.8 2 0 0 2 2 2 2 FAD binding domain Methyltransf_31 PF13847.1 EFW98540.1 - 4.2e-08 32.9 0.0 1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFW98540.1 - 4.6e-08 33.4 0.1 1.7e-07 31.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW98540.1 - 5.2e-06 26.7 0.0 1.5e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFW98540.1 - 1.4e-05 24.3 0.0 2.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFW98540.1 - 5.3e-05 23.2 0.2 0.00076 19.4 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFW98540.1 - 0.0047 16.3 0.0 0.014 14.8 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase NodS PF05401.6 EFW98540.1 - 0.012 14.9 0.0 0.029 13.7 0.0 1.6 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ribosomal_L23 PF00276.15 EFW98541.1 - 2.6e-12 46.5 0.0 4.9e-09 36.0 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L23 DUF2848 PF11010.3 EFW98541.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2848) Fungal_trans PF04082.13 EFW98542.1 - 3e-09 36.1 1.2 4.8e-09 35.4 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW98542.1 - 7.8e-07 28.9 12.7 1.5e-06 28.0 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPP_enzyme_M PF00205.17 EFW98542.1 - 0.017 14.8 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DUF3245 PF11595.3 EFW98543.1 - 0.023 14.9 3.2 0.023 14.9 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) RR_TM4-6 PF06459.7 EFW98543.1 - 2.7 7.7 8.0 3.5 7.4 5.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ras PF00071.17 EFW98544.1 - 1.2e-53 180.8 0.0 1.3e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFW98544.1 - 1.5e-17 64.1 0.0 2.1e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFW98544.1 - 7.5e-07 28.5 0.0 1e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PH PF00169.24 EFW98545.1 - 2.4e-24 85.4 1.7 3.3e-13 49.7 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_9 PF15410.1 EFW98545.1 - 9.1e-10 38.7 1.0 3.3e-05 24.0 0.1 3.6 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.1 EFW98545.1 - 5.4e-06 26.6 10.2 0.0044 17.2 0.1 4.1 3 2 0 3 3 3 2 Pleckstrin homology domain Mito_carr PF00153.22 EFW98546.1 - 7.4e-60 198.6 8.4 1.3e-21 76.0 0.1 4.4 4 1 0 4 4 4 3 Mitochondrial carrier protein MFS_1 PF07690.11 EFW98547.1 - 3.8e-29 101.4 37.3 3.8e-29 101.4 25.8 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1625 PF07787.7 EFW98547.1 - 0.35 10.0 1.6 0.73 9.0 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1625) zf-C2H2 PF00096.21 EFW98548.1 - 4.7e-09 36.0 12.0 0.034 14.4 0.8 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFW98548.1 - 5.3e-05 23.2 15.5 0.069 13.5 1.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger Neur_chan_memb PF02932.11 EFW98548.1 - 2.2 8.0 13.3 0.16 11.8 0.9 2.6 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Pyr_redox_3 PF13738.1 EFW98549.1 - 7.5e-22 78.3 0.0 7.9e-21 75.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFW98549.1 - 8.2e-13 48.6 0.0 6.6e-08 32.6 0.0 3.0 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFW98549.1 - 8.9e-11 40.6 0.1 7.2e-09 34.3 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFW98549.1 - 2.9e-07 29.7 0.1 9e-06 24.8 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 EFW98549.1 - 3.3e-06 27.3 0.5 0.058 13.8 0.0 3.7 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFW98549.1 - 1.6e-05 23.9 2.0 0.016 14.0 0.0 2.7 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 EFW98549.1 - 5e-05 23.2 0.0 0.0017 18.3 0.0 3.2 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 EFW98549.1 - 6.8e-05 22.0 0.5 0.032 13.2 0.0 2.6 3 0 0 3 3 3 2 FAD binding domain SnoaL_2 PF12680.2 EFW98549.1 - 0.00036 20.9 1.4 0.005 17.2 0.0 2.8 2 1 0 2 2 2 1 SnoaL-like domain 3HCDH_N PF02737.13 EFW98549.1 - 0.0015 18.2 0.2 0.07 12.7 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFW98549.1 - 0.016 15.3 0.1 4.5 7.3 0.0 3.1 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 EFW98549.1 - 0.027 14.2 2.0 5.6 6.7 0.0 3.5 4 0 0 4 4 4 0 FAD-NAD(P)-binding TrkA_N PF02254.13 EFW98549.1 - 0.03 14.3 0.1 6.8 6.7 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.9 EFW98549.1 - 0.048 12.1 0.0 0.48 8.8 0.0 2.5 3 0 0 3 3 3 0 HI0933-like protein 2-Hacid_dh_C PF02826.14 EFW98549.1 - 0.09 11.9 0.0 2.4 7.2 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.19 EFW98549.1 - 0.22 10.3 5.1 6.9 5.4 0.1 3.2 2 1 1 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.17 EFW98549.1 - 0.39 9.5 1.0 7.3 5.3 0.0 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A Aldose_epim PF01263.15 EFW98550.1 - 1.8e-44 152.0 0.0 2.6e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase YABBY PF04690.8 EFW98551.1 - 0.26 11.5 2.7 0.4 10.9 1.9 1.3 1 0 0 1 1 1 0 YABBY protein Glyoxalase PF00903.20 EFW98552.1 - 1e-18 67.5 0.6 2e-15 56.8 0.0 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EFW98552.1 - 2.7e-13 49.8 0.6 4.2e-06 26.7 0.0 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFW98552.1 - 1.9e-09 38.0 1.8 4.2e-05 24.0 0.0 2.8 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.1 EFW98552.1 - 3.2e-07 30.4 2.5 0.0067 16.3 0.0 3.5 3 1 0 3 3 3 2 Glyoxalase-like domain DUF2840 PF11000.3 EFW98552.1 - 0.071 12.6 0.2 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) Cellulase PF00150.13 EFW98553.1 - 7.3e-10 38.5 0.0 0.00014 21.1 0.0 2.6 1 1 1 2 2 2 2 Cellulase (glycosyl hydrolase family 5) PTS-HPr PF00381.14 EFW98553.1 - 0.029 14.2 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 PTS HPr component phosphorylation site Ecl1 PF12855.2 EFW98554.1 - 2.5e-07 29.8 1.0 4.7e-07 28.9 0.7 1.5 1 0 0 1 1 1 1 Life-span regulatory factor GATA PF00320.22 EFW98555.1 - 7.7e-16 57.1 5.9 7.7e-16 57.1 4.1 2.0 2 0 0 2 2 2 1 GATA zinc finger PAS PF00989.19 EFW98555.1 - 6.8e-09 35.5 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.6 EFW98555.1 - 7.4e-09 35.6 0.0 1.5e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 EFW98555.1 - 8.9e-07 29.2 0.0 1.9e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.5 EFW98555.1 - 0.00062 19.7 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.1 EFW98555.1 - 0.0024 17.7 0.1 0.0057 16.5 0.0 1.6 2 0 0 2 2 2 1 PAS domain TF_Zn_Ribbon PF08271.7 EFW98555.1 - 0.2 11.0 0.9 0.86 8.9 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding Epiglycanin_C PF14654.1 EFW98555.1 - 0.31 11.0 6.7 0.66 9.9 4.6 1.5 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region CHZ PF09649.5 EFW98556.1 - 3.9e-13 48.3 1.4 3.9e-13 48.3 1.0 2.0 2 0 0 2 2 2 1 Histone chaperone domain CHZ DUF3246 PF11596.3 EFW98556.1 - 0.53 9.5 8.1 0.62 9.3 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) TPR_11 PF13414.1 EFW98557.1 - 0.0091 15.6 1.2 0.094 12.3 0.1 2.3 2 0 0 2 2 2 1 TPR repeat Snf7 PF03357.16 EFW98558.1 - 1e-34 119.3 5.7 1.2e-34 119.1 4.0 1.1 1 0 0 1 1 1 1 Snf7 VWA_2 PF13519.1 EFW98558.1 - 0.071 13.2 0.0 3 7.9 0.0 2.2 1 1 1 2 2 2 0 von Willebrand factor type A domain zf-Tim10_DDP PF02953.10 EFW98559.1 - 1.4e-22 78.7 2.9 1.6e-22 78.5 2.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 EFW98559.1 - 0.12 11.8 1.7 0.15 11.5 1.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) WD40 PF00400.27 EFW98560.1 - 1.8e-18 65.6 16.7 1.7e-09 37.1 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF913 PF06025.7 EFW98561.1 - 7.4e-95 317.8 3.6 1.6e-94 316.7 0.0 3.1 3 0 0 3 3 3 1 Domain of Unknown Function (DUF913) HECT PF00632.20 EFW98561.1 - 3.5e-93 312.2 0.0 5.8e-93 311.5 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 EFW98561.1 - 8.6e-78 261.9 0.0 8.6e-78 261.9 0.0 3.1 4 0 0 4 4 4 1 Domain of Unknown Function (DUF908) DUF4414 PF14377.1 EFW98561.1 - 1.4e-29 102.1 8.2 1.4e-29 102.1 5.7 3.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4414) Xpo1 PF08389.7 EFW98561.1 - 0.33 10.8 3.1 18 5.2 0.2 3.6 3 0 0 3 3 3 0 Exportin 1-like protein adh_short PF00106.20 EFW98562.1 - 5.3e-31 107.7 3.2 7.7e-31 107.2 2.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW98562.1 - 9.4e-15 55.0 0.1 1.2e-14 54.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFW98562.1 - 2.9e-10 40.0 1.6 4.6e-10 39.4 1.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFW98562.1 - 1.1e-05 25.5 0.5 2e-05 24.6 0.3 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFW98562.1 - 0.006 16.0 0.2 0.026 13.9 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ApbA PF02558.11 EFW98562.1 - 0.038 13.4 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DAO PF01266.19 EFW98562.1 - 0.052 12.4 0.1 0.075 11.9 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Polysacc_synt_2 PF02719.10 EFW98562.1 - 0.076 11.9 0.0 0.19 10.6 0.0 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Ssl1 PF04056.9 EFW98563.1 - 1.6e-61 207.2 0.0 2.2e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 EFW98563.1 - 1.9e-16 59.7 6.0 1.9e-16 59.7 4.2 2.6 3 1 0 3 3 3 1 TFIIH C1-like domain VWA_2 PF13519.1 EFW98563.1 - 7.9e-10 39.1 0.1 1.5e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EFW98563.1 - 0.093 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain DZR PF12773.2 EFW98563.1 - 0.24 11.2 18.2 3.8 7.3 4.5 3.5 1 1 1 2 2 2 0 Double zinc ribbon WW PF00397.21 EFW98566.1 - 1.9e-07 30.8 7.1 3.3e-07 30.0 4.9 1.4 1 0 0 1 1 1 1 WW domain Ribonuc_red_sm PF00268.16 EFW98567.1 - 1.6e-120 401.3 2.9 2e-120 401.0 2.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain p450 PF00067.17 EFW98568.1 - 1.3e-64 218.4 0.0 1.6e-64 218.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RhaA PF06134.6 EFW98568.1 - 0.069 12.0 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 L-rhamnose isomerase (RhaA) FAD_binding_4 PF01565.18 EFW98569.1 - 1.7e-15 56.7 0.6 1.7e-15 56.7 0.4 1.5 2 0 0 2 2 2 1 FAD binding domain Citrate_synt PF00285.16 EFW98570.1 - 4.5e-103 344.7 0.0 6.1e-103 344.2 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase ORC4_C PF14629.1 EFW98572.1 - 1.1e-60 204.5 0.0 1.7e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 EFW98572.1 - 3.4e-18 66.3 1.4 7.7e-18 65.1 0.4 2.2 2 0 0 2 2 2 1 AAA ATPase domain PHD_2 PF13831.1 EFW98572.1 - 3.3e-11 42.3 1.9 5.7e-11 41.5 1.3 1.4 1 0 0 1 1 1 1 PHD-finger PHD PF00628.24 EFW98572.1 - 2.2e-10 40.0 4.6 3.7e-10 39.3 3.2 1.4 1 0 0 1 1 1 1 PHD-finger NACHT PF05729.7 EFW98572.1 - 2.6e-06 27.1 0.1 3.5e-05 23.5 0.0 2.5 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 EFW98572.1 - 3.1e-05 24.1 0.0 9.7e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EFW98572.1 - 3.3e-05 24.0 0.0 0.00014 22.0 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 EFW98572.1 - 0.00041 19.3 0.0 0.0007 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) C1_1 PF00130.17 EFW98572.1 - 0.0015 18.2 0.2 0.0035 17.0 0.1 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.11 EFW98572.1 - 0.0067 16.3 0.3 0.014 15.3 0.2 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger C1_3 PF07649.7 EFW98572.1 - 0.0085 16.1 2.8 0.021 14.8 1.9 1.7 1 0 0 1 1 1 1 C1-like domain Arch_ATPase PF01637.13 EFW98572.1 - 0.038 13.6 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 EFW98572.1 - 0.039 13.3 0.1 11 5.3 0.0 2.6 2 0 0 2 2 2 0 AAA-like domain AAA_5 PF07728.9 EFW98572.1 - 0.062 13.0 0.1 0.58 9.8 0.0 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 EFW98572.1 - 0.076 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Prok-RING_1 PF14446.1 EFW98572.1 - 0.11 12.3 2.5 0.23 11.2 1.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 KAP_NTPase PF07693.9 EFW98572.1 - 0.14 11.1 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain DZR PF12773.2 EFW98572.1 - 2.3 8.0 4.8 6.8 6.5 3.3 1.8 1 1 0 1 1 1 0 Double zinc ribbon COX4 PF02936.9 EFW98573.1 - 4.4e-48 162.6 0.0 5.1e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1104 PF06518.6 EFW98573.1 - 0.078 13.1 0.6 0.12 12.5 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) Ni_hydr_CYTB PF01292.15 EFW98573.1 - 0.091 12.1 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Transp_cyt_pur PF02133.10 EFW98574.1 - 1.2e-28 99.8 27.1 9.5e-28 96.9 18.8 1.9 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin GFO_IDH_MocA PF01408.17 EFW98575.1 - 1.5e-17 64.2 0.3 3.1e-17 63.1 0.2 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_11 PF08241.7 EFW98575.1 - 6.8e-11 42.5 0.3 9.3e-10 38.8 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW98575.1 - 7.8e-07 29.3 0.4 1.8e-05 25.0 0.1 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW98575.1 - 0.0046 17.4 0.0 0.023 15.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW98575.1 - 0.0055 16.7 0.4 0.027 14.4 0.2 2.2 2 0 0 2 2 2 1 Methyltransferase domain F420_oxidored PF03807.12 EFW98575.1 - 0.0098 16.2 0.1 0.023 15.1 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Methyltransf_23 PF13489.1 EFW98575.1 - 0.023 14.4 0.0 0.067 12.9 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFW98575.1 - 0.034 14.7 0.4 0.15 12.6 0.1 2.3 2 0 0 2 2 2 0 Methyltransferase domain HMG_box PF00505.14 EFW98576.1 - 4.6e-25 87.6 0.9 6.7e-25 87.1 0.6 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFW98576.1 - 3.5e-18 65.7 1.2 4.8e-18 65.2 0.8 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 EFW98576.1 - 0.002 17.9 0.6 0.0039 16.9 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box 5 DUF1014 PF06244.7 EFW98576.1 - 0.037 14.2 0.4 0.1 12.7 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1014) CH PF00307.26 EFW98577.1 - 1.9e-40 137.2 0.3 1.1e-20 73.7 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.5 EFW98577.1 - 2.6e-26 91.3 0.0 6.6e-26 90.0 0.0 1.7 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.3 EFW98577.1 - 1.7e-13 50.0 0.1 2.4e-08 33.4 0.1 2.6 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.1 EFW98577.1 - 0.00038 20.1 0.1 0.0043 16.8 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 EFW98577.1 - 0.0012 18.4 1.1 0.041 13.5 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 EFW98577.1 - 0.016 14.4 0.2 0.16 11.3 0.0 2.5 2 0 0 2 2 2 0 EF hand UPF0149 PF03695.8 EFW98577.1 - 0.03 14.1 1.0 0.17 11.7 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0149) EF-hand_7 PF13499.1 EFW98577.1 - 0.068 13.3 0.3 0.34 11.0 0.2 2.2 1 0 0 1 1 1 0 EF-hand domain pair Ank_2 PF12796.2 EFW98578.1 - 6.3e-28 96.9 0.0 2e-17 63.2 0.0 2.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) DIL PF01843.14 EFW98578.1 - 8.9e-18 64.1 6.3 1.5e-11 44.0 0.3 2.8 2 1 1 3 3 3 2 DIL domain Ank PF00023.25 EFW98578.1 - 1.1e-16 59.6 0.0 2e-06 27.3 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 EFW98578.1 - 6.3e-13 48.5 0.1 2e-07 31.0 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFW98578.1 - 1.1e-12 48.0 0.2 1.2e-05 25.7 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98578.1 - 2.2e-11 42.8 0.3 0.013 15.6 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat YL1 PF05764.8 EFW98579.1 - 3.8e-41 141.2 26.7 3.8e-41 141.2 18.5 4.6 4 1 0 4 4 4 1 YL1 nuclear protein YL1_C PF08265.6 EFW98579.1 - 2.7e-12 45.9 0.9 4.4e-12 45.3 0.6 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Nop14 PF04147.7 EFW98581.1 - 0.0075 14.2 2.0 0.0087 14.0 1.4 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 EFW98581.1 - 0.11 10.5 2.6 0.16 9.9 1.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.1 EFW98581.1 - 0.22 11.6 12.0 0.18 11.9 6.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Sigma70_ner PF04546.8 EFW98581.1 - 0.57 9.7 3.6 0.98 8.9 2.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.6 EFW98581.1 - 1.3 8.7 4.7 0.41 10.4 1.2 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal Spt5_N PF11942.3 EFW98581.1 - 9.5 6.9 13.9 1 10.0 5.5 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal AA_permease PF00324.16 EFW98586.1 - 6.6e-85 285.2 30.9 8.4e-85 284.9 21.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFW98586.1 - 1.4e-22 79.8 31.6 2e-22 79.3 21.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2665 PF11654.3 EFW98586.1 - 0.0024 17.4 0.2 0.0085 15.6 0.1 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2665) Mito_carr PF00153.22 EFW98587.1 - 1.3e-58 194.7 0.6 8.2e-21 73.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein KOW PF00467.24 EFW98588.1 - 0.0002 20.9 0.3 0.00034 20.1 0.2 1.4 1 0 0 1 1 1 1 KOW motif GYF PF02213.11 EFW98589.1 - 1.1e-09 37.7 0.3 2.1e-09 36.8 0.2 1.5 1 0 0 1 1 1 1 GYF domain Gluconate_2-dh3 PF13618.1 EFW98589.1 - 0.082 13.0 2.7 0.22 11.6 1.8 1.8 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 DAO PF01266.19 EFW98590.1 - 5.2e-33 114.4 0.2 7e-33 114.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase PGM_PMM_I PF02878.11 EFW98591.1 - 3.9e-32 110.6 0.0 5.7e-32 110.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 EFW98591.1 - 1.8e-23 82.6 0.0 3e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 EFW98591.1 - 1.5e-15 57.3 0.1 4.2e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EFW98591.1 - 7.2e-10 38.7 0.0 1.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Amidase PF01425.16 EFW98592.1 - 4.9e-87 292.5 7.6 3.3e-86 289.8 5.3 2.1 1 1 0 1 1 1 1 Amidase HEV_ORF1 PF02444.11 EFW98592.1 - 0.0046 17.1 0.7 0.02 15.0 0.5 2.1 1 0 0 1 1 1 1 Hepatitis E virus ORF-2 (Putative capsid protein) CDC73 PF05179.9 EFW98593.1 - 1.9e-42 145.5 0.1 1.8e-41 142.3 0.0 2.2 2 1 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family Amidohydro_2 PF04909.9 EFW98595.1 - 1.5e-14 54.2 8.4 2.4e-14 53.5 5.8 1.3 1 1 0 1 1 1 1 Amidohydrolase Na_H_Exchanger PF00999.16 EFW98596.1 - 7.5e-44 149.7 18.6 1e-43 149.3 12.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family LSM PF01423.17 EFW98598.1 - 3.4e-12 45.7 0.0 7e-12 44.7 0.0 1.5 1 1 0 1 1 1 1 LSM domain DUF2892 PF11127.3 EFW98599.1 - 7.6 6.4 10.9 2 8.3 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) VTC PF09359.5 EFW98600.1 - 2.3e-87 292.6 0.0 2.1e-86 289.4 0.0 2.1 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 EFW98600.1 - 2.7e-21 76.6 6.1 1.2e-18 67.9 4.2 2.9 1 1 0 1 1 1 1 SPX domain DUF202 PF02656.10 EFW98600.1 - 1.5e-08 34.7 7.6 4.8e-08 33.0 5.3 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF202) Pkinase PF00069.20 EFW98602.1 - 4e-64 216.2 0.0 8.2e-64 215.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW98602.1 - 5.9e-37 127.1 0.0 2.2e-31 108.9 0.1 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFW98602.1 - 1.4e-06 27.4 0.1 0.0017 17.3 0.1 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EFW98602.1 - 0.00049 19.9 0.1 0.0036 17.0 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFW98602.1 - 0.022 13.8 0.2 0.061 12.3 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EFW98602.1 - 0.036 13.4 0.1 0.078 12.3 0.1 1.5 1 0 0 1 1 1 0 RIO1 family ketoacyl-synt PF00109.21 EFW98603.1 - 1.8e-53 181.5 0.0 1.5e-50 172.0 0.0 2.2 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFW98603.1 - 4.3e-40 136.2 0.1 1.9e-39 134.1 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 EFW98603.1 - 8.7e-07 28.5 0.3 1.2e-06 28.1 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain MOFRL PF05161.8 EFW98603.1 - 0.052 13.6 0.1 0.38 10.8 0.1 2.2 2 0 0 2 2 2 0 MOFRL family 4F5 PF04419.9 EFW98604.1 - 9.2e-09 35.9 16.2 9.2e-09 35.9 11.3 2.1 2 0 0 2 2 2 1 4F5 protein family DUF724 PF05266.9 EFW98604.1 - 0.96 9.0 7.8 1.1 8.8 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Sec62 PF03839.11 EFW98604.1 - 2 7.7 5.3 2.2 7.6 3.6 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Dsh_C PF12316.3 EFW98604.1 - 4.5 7.3 6.8 4.8 7.2 4.7 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Cys_Met_Meta_PP PF01053.15 EFW98606.1 - 7.8e-102 340.4 0.0 1.4e-81 273.7 0.0 3.0 1 1 2 3 3 3 3 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EFW98606.1 - 2.6e-13 49.6 0.0 4e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFW98606.1 - 1.2e-10 40.7 0.1 1.9e-10 40.0 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFW98606.1 - 2.4e-08 33.4 0.3 3.7e-08 32.8 0.2 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EFW98606.1 - 0.0019 17.3 0.1 0.0056 15.8 0.1 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase SelA PF03841.8 EFW98606.1 - 0.013 14.2 0.0 0.05 12.3 0.0 1.8 1 1 0 1 1 1 0 L-seryl-tRNA selenium transferase SLA_LP_auto_ag PF05889.8 EFW98606.1 - 0.029 12.8 0.0 0.046 12.1 0.0 1.2 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) GDC-P PF02347.11 EFW98606.1 - 0.038 12.6 0.0 0.057 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein Sugar_tr PF00083.19 EFW98607.1 - 5.4e-76 255.9 21.2 7e-76 255.6 14.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Pribosyltran_N PF13793.1 EFW98607.1 - 7.7e-38 128.8 0.0 1.8e-37 127.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase MFS_1 PF07690.11 EFW98607.1 - 6.8e-30 103.9 21.9 1.3e-29 103.0 15.2 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Pribosyl_synth PF14572.1 EFW98607.1 - 2.1e-26 92.8 3.7 6.1e-24 84.7 2.1 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain BT1 PF03092.11 EFW98607.1 - 0.0026 16.5 3.2 0.013 14.1 2.2 1.9 1 1 0 1 1 1 1 BT1 family Pribosyltran PF00156.22 EFW98607.1 - 0.0071 16.0 0.4 0.019 14.7 0.3 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pex14_N PF04695.8 EFW98607.1 - 0.12 12.4 0.6 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GMC_oxred_N PF00732.14 EFW98608.1 - 2.7e-60 204.0 0.0 6.8e-60 202.7 0.0 1.6 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFW98608.1 - 4.3e-32 111.3 0.0 7.9e-32 110.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 EFW98608.1 - 0.0026 16.7 0.1 0.0045 15.9 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 EFW98608.1 - 0.019 13.9 0.2 0.062 12.1 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW98608.1 - 0.028 14.4 0.4 0.094 12.7 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 EFW98608.1 - 0.028 13.0 0.1 0.039 12.5 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase UFD1 PF03152.9 EFW98609.1 - 1.2e-64 216.6 0.0 1.5e-64 216.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DAO PF01266.19 EFW98610.1 - 1.8e-48 165.2 0.2 2.7e-48 164.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFW98610.1 - 6.3e-07 28.5 3.1 5.7e-06 25.4 2.2 2.2 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EFW98610.1 - 3.7e-06 26.2 0.3 0.0015 17.6 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFW98610.1 - 0.00076 18.4 0.2 0.1 11.5 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFW98610.1 - 0.0017 18.3 0.2 0.008 16.1 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFW98610.1 - 0.0031 17.4 0.0 0.0065 16.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EFW98610.1 - 0.012 15.2 0.2 0.025 14.2 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.12 EFW98610.1 - 0.019 14.0 0.4 0.3 10.1 0.1 2.2 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.14 EFW98610.1 - 0.028 13.4 0.8 0.64 9.0 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.9 EFW98610.1 - 0.068 11.6 0.3 0.098 11.1 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.22 EFW98610.1 - 0.078 13.3 0.1 0.4 11.1 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TruD PF01142.13 EFW98611.1 - 4e-54 183.7 0.0 2.4e-50 171.3 0.0 3.3 3 0 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) DUF3090 PF11290.3 EFW98611.1 - 0.079 12.4 0.2 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) p12I PF12233.3 EFW98612.1 - 0.15 12.3 0.6 1.3 9.3 0.1 2.3 2 0 0 2 2 2 0 Human adult T cell leukemia/lymphoma virus protein DEAD PF00270.24 EFW98613.1 - 8e-40 136.0 0.0 3.3e-39 134.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW98613.1 - 2.9e-27 94.3 0.1 6.1e-27 93.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFW98613.1 - 9.8e-05 21.2 0.0 0.00013 20.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFW98613.1 - 0.012 15.4 0.3 0.026 14.3 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit BTV_NS2 PF04514.7 EFW98613.1 - 3.4 6.4 5.8 5.1 5.8 4.0 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Cwf_Cwc_15 PF04889.7 EFW98613.1 - 5.1 6.7 12.5 8.6 5.9 8.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pro-kuma_activ PF09286.6 EFW98614.1 - 3.6e-43 147.0 0.0 6.7e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFW98614.1 - 5.7e-05 22.4 0.2 0.00011 21.4 0.1 1.4 1 0 0 1 1 1 1 Subtilase family CRA PF06589.6 EFW98615.1 - 0.085 12.1 0.1 0.17 11.1 0.1 1.4 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) CLASP_N PF12348.3 EFW98616.1 - 6.3e-127 421.5 0.4 2.5e-87 291.9 0.0 2.3 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.17 EFW98616.1 - 0.0008 19.2 0.3 3.1 8.1 0.0 5.1 6 0 0 6 6 6 1 HEAT repeat DUF2999 PF11212.3 EFW98616.1 - 0.029 14.3 0.1 0.18 11.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2999) HEAT_2 PF13646.1 EFW98616.1 - 0.034 14.4 2.8 0.6 10.4 0.1 4.2 3 2 0 3 3 3 0 HEAT repeats Condensin2nSMC PF12422.3 EFW98616.1 - 0.19 11.4 0.0 0.54 9.9 0.0 1.7 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit Rgp1 PF08737.5 EFW98617.1 - 9.5e-109 364.2 0.0 1.8e-108 363.3 0.0 1.5 1 0 0 1 1 1 1 Rgp1 Ribonuclease_3 PF00636.21 EFW98617.1 - 8.8e-35 119.5 0.0 1.9e-17 63.7 0.0 3.4 2 1 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EFW98617.1 - 2.3e-21 76.0 0.0 8.9e-11 41.8 0.0 3.6 2 1 0 2 2 2 2 Ribonuclease-III-like DEAD PF00270.24 EFW98617.1 - 6.1e-14 51.8 0.1 1.3e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Dicer_dimer PF03368.9 EFW98617.1 - 5.2e-11 42.1 0.0 1.5e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.26 EFW98617.1 - 5.8e-11 42.1 0.0 1.8e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW98617.1 - 1.6e-06 28.0 1.4 2.8e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Phage_int_SAM_5 PF13102.1 EFW98617.1 - 0.25 11.3 0.9 0.67 9.9 0.6 1.6 1 0 0 1 1 1 0 Phage integrase SAM-like domain HATPase_c PF02518.21 EFW98618.1 - 9.6e-24 83.2 0.0 1.9e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.6 EFW98618.1 - 6.8e-22 77.3 2.5 9.8e-13 48.0 0.5 3.7 3 0 0 3 3 3 3 PAS fold HisKA PF00512.20 EFW98618.1 - 4e-21 74.7 0.1 1.1e-20 73.3 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 EFW98618.1 - 5.1e-19 68.3 0.0 1.5e-18 66.8 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.1 EFW98618.1 - 6.9e-16 58.5 0.0 4.5e-08 33.4 0.0 3.3 2 1 0 2 2 2 2 PAS domain PAS PF00989.19 EFW98618.1 - 9.1e-10 38.3 0.0 0.0002 21.0 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 EFW98618.1 - 2.1e-08 34.1 0.4 2.5e-06 27.5 0.2 3.1 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.1 EFW98618.1 - 0.02 14.8 0.0 0.49 10.3 0.0 2.4 2 0 0 2 2 2 0 PAS domain SCO1-SenC PF02630.9 EFW98619.1 - 3.7e-58 195.9 0.0 4.9e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 EFW98619.1 - 0.00031 20.3 0.0 0.00055 19.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFW98619.1 - 0.059 12.9 0.0 0.8 9.2 0.0 2.1 1 1 0 1 1 1 0 Redoxin PCI PF01399.22 EFW98620.1 - 6.4e-19 68.2 0.1 1.8e-18 66.8 0.1 1.8 1 0 0 1 1 1 1 PCI domain Neugrin PF06413.6 EFW98620.1 - 1.6e-12 47.7 0.7 1.6e-12 47.7 0.5 2.0 2 0 0 2 2 2 1 Neugrin MRP-L20 PF12824.2 EFW98620.1 - 2.3e-05 24.4 2.9 7.2e-05 22.8 2.0 1.9 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 TPR_8 PF13181.1 EFW98620.1 - 0.00073 19.1 0.8 25 4.9 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DDRGK PF09756.4 EFW98620.1 - 0.00087 18.7 0.2 0.00087 18.7 0.2 2.2 2 0 0 2 2 2 1 DDRGK domain ASFV_J13L PF05568.6 EFW98620.1 - 0.0016 18.0 5.0 0.004 16.7 3.4 1.7 1 0 0 1 1 1 1 African swine fever virus J13L protein TPR_7 PF13176.1 EFW98620.1 - 0.0037 16.9 3.1 4.6 7.2 0.3 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat HTH_Crp_2 PF13545.1 EFW98620.1 - 0.054 13.2 0.1 0.29 10.9 0.0 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HEV_ORF1 PF02444.11 EFW98621.1 - 3 8.0 9.9 0.7 10.1 3.0 2.7 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) LSM PF01423.17 EFW98624.1 - 4.7e-19 67.7 0.0 5.5e-19 67.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EFW98624.1 - 0.00051 19.9 0.1 0.00063 19.6 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.2 EFW98624.1 - 0.074 12.8 0.1 0.091 12.5 0.1 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain IceA2 PF05862.6 EFW98624.1 - 0.13 11.9 1.0 0.17 11.6 0.1 1.7 2 0 0 2 2 2 0 Helicobacter pylori IceA2 protein FAD_binding_1 PF00667.15 EFW98625.1 - 4e-61 206.2 0.0 5.7e-61 205.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EFW98625.1 - 7.6e-34 116.7 0.6 1.6e-33 115.7 0.4 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EFW98625.1 - 3.3e-21 75.9 0.0 2.5e-20 73.0 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 EFW98625.1 - 0.067 13.1 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain Shikimate_DH PF01488.15 EFW98625.1 - 0.1 12.6 0.1 0.62 10.1 0.1 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Choline_transpo PF04515.7 EFW98626.1 - 5.5e-12 45.0 19.3 5.5e-12 45.0 13.4 3.1 3 0 0 3 3 3 2 Plasma-membrane choline transporter Ribosomal_L7Ae PF01248.21 EFW98628.1 - 3.5e-28 96.9 0.7 4.4e-28 96.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PucR PF07905.6 EFW98628.1 - 0.092 12.3 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family Pkinase PF00069.20 EFW98630.1 - 1.1e-60 205.0 0.0 1.5e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW98630.1 - 2.7e-32 111.8 0.0 6.1e-31 107.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EFW98630.1 - 0.0076 15.0 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase SURF1 PF02104.10 EFW98631.1 - 4e-59 200.0 0.0 5.3e-59 199.6 0.0 1.2 1 0 0 1 1 1 1 SURF1 family RRM_1 PF00076.17 EFW98632.1 - 3.4e-60 199.5 0.0 9.5e-21 73.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98632.1 - 1.3e-42 143.6 0.0 7.8e-15 54.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW98632.1 - 2.6e-29 100.8 0.0 1e-10 41.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFW98632.1 - 1.6e-07 30.9 0.0 0.0085 15.8 0.0 3.5 3 0 0 3 3 3 3 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 EFW98632.1 - 0.00044 20.1 0.0 0.92 9.4 0.0 2.4 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_3 PF08777.6 EFW98632.1 - 0.029 14.2 0.0 0.53 10.1 0.0 2.5 3 0 0 3 3 3 0 RNA binding motif Ras PF00071.17 EFW98633.1 - 9.4e-44 148.6 0.1 1.2e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFW98633.1 - 3.5e-12 46.8 0.1 7.4e-12 45.8 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 EFW98633.1 - 3.7e-06 26.4 0.0 4.9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 EFW98633.1 - 2.6e-05 23.5 0.1 3.1e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family BTB PF00651.26 EFW98634.1 - 3.5e-06 26.9 0.0 5.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Hormone_2 PF00123.15 EFW98634.1 - 0.017 14.9 0.0 0.044 13.6 0.0 1.8 1 0 0 1 1 1 0 Peptide hormone ATP_synt_H PF05493.8 EFW98635.1 - 3e-26 91.2 2.7 3.4e-26 91.0 1.9 1.0 1 0 0 1 1 1 1 ATP synthase subunit H Polysacc_synt_C PF14667.1 EFW98635.1 - 0.036 13.8 0.4 0.043 13.6 0.3 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain AmiS_UreI PF02293.10 EFW98635.1 - 0.045 13.4 0.1 0.053 13.1 0.1 1.0 1 0 0 1 1 1 0 AmiS/UreI family transporter ARL6IP6 PF15062.1 EFW98635.1 - 0.075 12.9 0.2 0.1 12.5 0.1 1.3 1 1 0 1 1 1 0 Haemopoietic lineage transmembrane helix YfhO PF09586.5 EFW98635.1 - 0.1 10.6 0.2 0.096 10.6 0.2 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4131 PF13567.1 EFW98635.1 - 0.47 9.8 2.9 0.49 9.7 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) FixQ PF05545.6 EFW98635.1 - 2 8.1 4.8 0.77 9.4 0.1 2.1 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ SE PF08491.5 EFW98636.1 - 1.1e-94 316.4 0.0 1.3e-94 316.0 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 EFW98636.1 - 9.5e-13 47.9 0.0 1.3e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFW98636.1 - 1.7e-09 37.0 0.4 4.9e-07 28.9 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.17 EFW98636.1 - 0.00013 20.9 0.1 0.14 11.0 0.1 2.0 2 0 0 2 2 2 2 Glucose inhibited division protein A 3HCDH_N PF02737.13 EFW98636.1 - 0.00065 19.4 0.1 0.0012 18.4 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.1 EFW98636.1 - 0.001 19.0 0.3 0.0024 17.8 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.15 EFW98636.1 - 0.0011 19.0 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.9 EFW98636.1 - 0.0016 18.3 0.6 0.0041 17.0 0.4 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFW98636.1 - 0.0022 17.1 0.0 0.0042 16.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 EFW98636.1 - 0.0024 16.7 1.6 0.019 13.8 0.5 2.0 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.9 EFW98636.1 - 0.0035 16.0 0.4 0.86 8.1 0.2 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.18 EFW98636.1 - 0.0054 16.4 0.0 0.0095 15.6 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.7 EFW98636.1 - 0.0063 15.4 0.2 0.02 13.8 0.1 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.2 EFW98636.1 - 0.0063 15.6 0.3 0.01 14.9 0.2 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFW98636.1 - 0.028 14.8 0.8 0.056 13.8 0.2 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.20 EFW98636.1 - 0.048 13.5 0.3 0.091 12.6 0.2 1.4 1 0 0 1 1 1 0 short chain dehydrogenase ApbA PF02558.11 EFW98636.1 - 0.064 12.6 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 EFW98636.1 - 0.07 13.1 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_2 PF03446.10 EFW98636.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HI0933_like PF03486.9 EFW98636.1 - 0.15 10.5 0.2 0.21 9.9 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein RNase_H PF00075.19 EFW98637.1 - 1.4e-27 96.6 0.0 3.9e-27 95.1 0.0 1.8 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 EFW98637.1 - 3.5e-24 84.5 4.8 5.2e-12 45.5 0.3 2.8 2 0 0 2 2 2 2 Caulimovirus viroplasmin dCMP_cyt_deam_1 PF00383.17 EFW98637.1 - 4e-09 36.0 0.3 8.1e-07 28.6 0.2 3.6 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region Myc_N PF01056.13 EFW98637.1 - 0.0095 15.1 2.8 0.027 13.6 2.0 1.7 1 0 0 1 1 1 1 Myc amino-terminal region Bd3614-deam PF14439.1 EFW98637.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.4 3 0 0 3 3 3 0 Bd3614-like deaminase DUF4611 PF15387.1 EFW98637.1 - 0.35 11.0 13.3 0.021 14.9 5.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nucleoplasmin PF03066.10 EFW98637.1 - 0.37 10.3 9.5 0.75 9.3 6.6 1.4 1 0 0 1 1 1 0 Nucleoplasmin Ribosomal_60s PF00428.14 EFW98637.1 - 0.54 10.6 19.6 0.064 13.6 6.3 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.8 EFW98637.1 - 1.7 6.3 9.0 2.7 5.6 6.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.5 EFW98637.1 - 6.6 7.0 14.2 0.68 10.1 6.3 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ank_2 PF12796.2 EFW98638.1 - 7.8e-79 260.1 1.1 3.5e-19 68.9 0.0 6.0 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFW98638.1 - 4.5e-48 160.2 9.3 2.1e-07 30.9 0.0 8.6 2 1 9 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.25 EFW98638.1 - 3.4e-47 155.9 1.1 3.2e-05 23.5 0.1 9.7 9 0 0 9 9 9 9 Ankyrin repeat Ank_4 PF13637.1 EFW98638.1 - 9.3e-41 137.5 0.3 6.2e-10 39.3 0.0 7.0 3 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98638.1 - 1.8e-36 120.4 0.0 0.0012 18.8 0.0 10.7 10 0 0 10 10 10 8 Ankyrin repeat NACHT PF05729.7 EFW98638.1 - 1e-05 25.2 0.2 2.4e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EFW98638.1 - 4.1e-05 23.6 0.0 0.00014 21.9 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFW98638.1 - 0.011 15.9 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EFW98638.1 - 0.12 11.9 0.1 0.36 10.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFW98638.1 - 0.12 12.6 0.0 0.35 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.17 EFW98639.1 - 4.8e-20 70.9 0.4 2.6e-12 46.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98639.1 - 1.8e-12 47.0 0.8 3.4e-08 33.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW98639.1 - 0.0016 18.2 0.8 1 9.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LSM PF01423.17 EFW98641.1 - 8.1e-09 34.9 0.0 1.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EFW98641.1 - 0.0014 18.5 0.0 0.0023 17.7 0.0 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain tRNA-synt_2 PF00152.15 EFW98644.1 - 3.4e-69 233.1 0.0 4.3e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFW98644.1 - 1e-10 41.3 0.0 1.8e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EFW98644.1 - 3.6e-05 23.0 0.0 0.0062 15.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-like PF12869.2 EFW98644.1 - 0.0064 15.9 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 tRNA_anti-like tRNA-synt_2b PF00587.20 EFW98644.1 - 0.078 12.5 0.0 4.8 6.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) DUF2293 PF10056.4 EFW98645.1 - 4.9e-21 74.4 0.4 2.6e-20 72.1 0.1 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) DCP2 PF05026.8 EFW98647.1 - 6e-32 109.4 0.5 1.3e-31 108.3 0.3 1.6 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 EFW98647.1 - 4.2e-14 52.3 0.0 8e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.1 EFW98648.1 - 5.1e-35 119.6 0.3 7.1e-35 119.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) GFO_IDH_MocA PF01408.17 EFW98649.1 - 2.9e-14 53.6 0.3 2.2e-13 50.7 0.2 2.2 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EFW98649.1 - 0.00096 18.9 0.1 0.0028 17.4 0.1 1.9 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain AAA PF00004.24 EFW98650.1 - 5.9e-18 65.3 0.0 1e-17 64.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFW98650.1 - 2.7e-05 24.9 0.0 0.00012 22.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFW98650.1 - 0.00017 21.2 0.0 0.00034 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFW98650.1 - 0.00018 21.6 0.1 0.00065 19.8 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 EFW98650.1 - 0.00096 19.4 0.2 0.0045 17.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFW98650.1 - 0.0062 16.5 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 EFW98650.1 - 0.009 15.9 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFW98650.1 - 0.014 15.2 0.1 0.04 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 EFW98650.1 - 0.044 12.8 0.0 0.044 12.8 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus ArgK PF03308.11 EFW98650.1 - 0.054 12.2 0.1 1.4 7.5 0.1 2.2 2 0 0 2 2 2 0 ArgK protein AAA_28 PF13521.1 EFW98650.1 - 0.073 13.0 0.2 0.32 10.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.17 EFW98650.1 - 0.082 11.7 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.1 EFW98650.1 - 0.082 12.6 0.3 0.2 11.4 0.2 1.6 1 0 0 1 1 1 0 Part of AAA domain PAT1 PF09770.4 EFW98650.1 - 1.9 6.6 15.2 2.9 6.0 10.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Mod_r PF07200.8 EFW98651.1 - 0.012 15.5 8.4 0.012 15.5 5.8 3.5 4 1 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DivIC PF04977.10 EFW98651.1 - 0.013 14.9 4.4 0.013 14.9 3.1 4.9 5 1 1 6 6 6 0 Septum formation initiator IncA PF04156.9 EFW98651.1 - 0.36 10.4 20.0 7.2 6.1 10.4 4.1 2 2 1 3 3 3 0 IncA protein NPV_P10 PF05531.7 EFW98651.1 - 0.58 10.4 23.9 1.5 9.1 0.1 6.0 5 2 2 7 7 7 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 EFW98651.1 - 0.79 8.8 20.4 9.7 5.2 0.1 3.7 3 1 0 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 EFW98651.1 - 3.5 7.4 16.0 3.9 7.2 2.6 4.1 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 EFW98651.1 - 4.1 5.7 23.5 0.82 8.0 10.0 2.6 2 1 0 2 2 2 0 AAA domain DUF904 PF06005.7 EFW98651.1 - 6.8 7.0 18.4 2.3 8.5 4.5 4.5 3 1 0 3 3 3 0 Protein of unknown function (DUF904) UPF0075 PF03702.9 EFW98652.1 - 6e-57 193.1 0.0 1.2e-56 192.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0075) SIS_2 PF13580.1 EFW98652.1 - 0.00012 21.8 0.1 0.0004 20.1 0.0 1.9 1 1 0 1 1 1 1 SIS domain SIS PF01380.17 EFW98652.1 - 0.00012 21.6 0.7 0.00044 19.8 0.0 2.1 2 0 0 2 2 2 1 SIS domain Catalase PF00199.14 EFW98653.1 - 7.9e-160 531.7 1.5 6.7e-99 331.1 0.9 2.0 1 1 1 2 2 2 2 Catalase Catalase-rel PF06628.7 EFW98653.1 - 1.5e-14 53.6 0.0 3e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive CLTH PF10607.4 EFW98654.1 - 6.2e-32 110.2 0.0 1e-31 109.5 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 EFW98654.1 - 9.6e-18 63.6 1.0 2.1e-17 62.5 0.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 EFW98654.1 - 4.6e-05 23.1 0.4 8e-05 22.3 0.3 1.4 1 0 0 1 1 1 1 Ring finger domain Rtf2 PF04641.7 EFW98654.1 - 0.00013 21.2 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_5 PF14634.1 EFW98654.1 - 0.0013 18.3 0.3 0.0022 17.6 0.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFW98654.1 - 0.021 14.4 0.8 0.039 13.6 0.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFW98654.1 - 0.026 14.5 0.8 0.048 13.7 0.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFW98654.1 - 0.041 13.5 0.4 0.074 12.7 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFW98654.1 - 0.13 12.1 0.7 0.28 11.1 0.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PALP PF00291.20 EFW98655.1 - 1.3e-62 211.8 0.1 1.9e-62 211.2 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SNARE PF05739.14 EFW98656.1 - 3.6e-10 39.3 1.7 5.1e-10 38.9 1.2 1.2 1 0 0 1 1 1 1 SNARE domain Peptidase_G2 PF11962.3 EFW98656.1 - 0.1 11.6 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase_G2, IMC autoproteolytic cleavage domain DUF1421 PF07223.6 EFW98656.1 - 1.9 8.2 4.1 2.3 7.9 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1421) VPS9 PF02204.13 EFW98657.1 - 1.3e-16 60.4 0.0 2.8e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 EFW98657.1 - 2.1e-16 59.5 0.5 7.5e-11 41.9 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFW98657.1 - 1.3e-11 44.6 0.0 1.2e-07 31.9 0.0 3.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFW98657.1 - 6.4e-10 39.2 0.0 0.0071 16.8 0.0 5.1 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98657.1 - 6.3e-09 35.2 0.1 0.2 11.9 0.0 5.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.25 EFW98657.1 - 5.4e-06 25.9 2.3 0.023 14.4 0.0 4.6 5 1 0 5 5 5 2 Ankyrin repeat PX PF00787.19 EFW98657.1 - 0.099 12.4 0.0 0.3 10.9 0.0 1.8 1 0 0 1 1 1 0 PX domain OmpH PF03938.9 EFW98657.1 - 0.16 11.9 2.0 0.29 11.0 1.4 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Arv1 PF04161.8 EFW98658.1 - 2e-46 158.5 0.0 3e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 Arv1-like family Chs3p PF12271.3 EFW98659.1 - 5e-93 311.2 6.9 5.8e-93 311.0 4.8 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit FixQ PF05545.6 EFW98659.1 - 8.2 6.1 7.5 0.73 9.5 0.1 2.9 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ CUE PF02845.11 EFW98660.1 - 2.5e-11 42.8 0.0 4.6e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 CUE domain Calcipressin PF04847.7 EFW98661.1 - 5.7e-43 146.6 0.4 1.4e-42 145.3 0.3 1.7 1 1 0 1 1 1 1 Calcipressin TrkH PF02386.11 EFW98663.1 - 7.8e-117 389.8 17.6 1.7e-116 388.6 7.6 2.1 2 0 0 2 2 2 2 Cation transport protein PC_rep PF01851.17 EFW98665.1 - 2.3e-22 77.8 15.4 1.7e-06 27.9 0.1 9.3 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EFW98665.1 - 5.2e-07 29.8 0.8 0.15 12.3 0.0 4.2 4 0 0 4 4 4 2 HEAT repeats DUF4109 PF13397.1 EFW98665.1 - 0.15 12.4 0.4 0.45 10.9 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4109) TPT PF03151.11 EFW98666.1 - 2.2e-38 131.2 1.6 2.2e-38 131.2 1.1 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 EFW98666.1 - 1e-07 31.1 10.2 6.2e-07 28.6 7.0 2.0 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 EFW98666.1 - 7.7e-06 25.9 30.8 0.001 19.1 6.3 3.0 3 1 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.10 EFW98666.1 - 0.0099 14.9 0.4 0.32 10.0 0.1 2.2 2 0 0 2 2 2 1 Nucleotide-sugar transporter Transp_cyt_pur PF02133.10 EFW98667.1 - 2.4e-47 161.5 26.4 3.4e-47 161.0 18.3 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin AAA_18 PF13238.1 EFW98668.1 - 1.4e-05 25.3 0.0 7.1e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFW98668.1 - 0.0059 16.4 0.6 0.025 14.4 0.4 2.0 1 1 0 1 1 1 1 AAA domain EPSP_synthase PF00275.15 EFW98669.1 - 2.4e-128 428.1 0.0 5.5e-128 426.9 0.0 1.6 2 0 0 2 2 2 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 EFW98669.1 - 8.2e-102 339.5 0.0 1.3e-101 338.9 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.10 EFW98669.1 - 3.2e-62 210.1 0.0 5e-62 209.4 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 EFW98669.1 - 8.9e-34 116.6 0.0 2.8e-32 111.7 0.0 2.4 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.6 EFW98669.1 - 1.5e-22 79.4 0.0 3.9e-22 78.0 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.1 EFW98669.1 - 1.5e-08 34.3 0.0 3.5e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.15 EFW98669.1 - 1.1e-07 31.9 0.0 3.2e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_17 PF13207.1 EFW98669.1 - 2e-06 28.5 0.0 4.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFW98669.1 - 0.1 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EFW98669.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin HAD_2 PF13419.1 EFW98670.1 - 1.1e-25 90.8 0.3 1.4e-25 90.5 0.2 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFW98670.1 - 0.0085 16.5 0.0 0.022 15.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mitofilin PF09731.4 EFW98671.1 - 3.4e-140 468.4 2.6 4.2e-140 468.1 1.8 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein UDPG_MGDP_dh PF00984.14 EFW98672.1 - 5.1e-29 100.3 0.0 1.1e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 EFW98672.1 - 3.9e-22 78.3 0.0 3.9e-17 62.3 0.0 2.5 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh_N PF03721.9 EFW98672.1 - 1.1e-21 77.0 0.0 2.5e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-RING_2 PF13639.1 EFW98674.1 - 6.1e-14 51.5 4.8 1.1e-13 50.7 3.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFW98674.1 - 1.4e-07 31.4 0.6 2.8e-07 30.5 0.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EFW98674.1 - 1e-06 28.2 3.2 1.9e-06 27.4 2.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFW98674.1 - 9.2e-06 25.5 5.1 9.2e-06 25.5 3.5 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFW98674.1 - 1.1e-05 25.0 2.3 1.8e-05 24.3 1.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFW98674.1 - 7.5e-05 22.3 2.0 0.00014 21.4 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFW98674.1 - 0.0024 17.6 0.8 0.0047 16.7 0.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 EFW98674.1 - 0.016 14.8 1.9 0.03 13.9 1.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-HC5HC2H PF13771.1 EFW98674.1 - 0.074 13.2 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING-like PF08746.6 EFW98674.1 - 0.088 12.8 2.9 0.15 12.0 2.0 1.4 1 0 0 1 1 1 0 RING-like domain PHD PF00628.24 EFW98674.1 - 0.36 10.5 2.5 0.88 9.3 1.8 1.7 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 EFW98674.1 - 0.66 9.7 2.9 4.7 7.0 0.9 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 WD40 PF00400.27 EFW98675.1 - 4.6e-06 26.3 14.0 0.0089 15.8 0.0 6.7 7 1 1 8 8 8 3 WD domain, G-beta repeat GrpE PF01025.14 EFW98676.1 - 3.9e-48 163.1 4.8 3.9e-48 163.1 3.4 1.8 1 1 1 2 2 2 1 GrpE Bap31 PF05529.7 EFW98676.1 - 0.16 11.4 0.8 0.28 10.6 0.5 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like BSP PF04450.7 EFW98677.1 - 9.3e-74 247.3 0.0 1.7e-73 246.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase of plants and bacteria ETC_C1_NDUFA5 PF04716.9 EFW98677.1 - 4e-20 71.1 0.6 4e-20 71.1 0.4 2.4 2 0 0 2 2 2 1 ETC complex I subunit conserved region RNA_pol_I_TF PF04090.7 EFW98677.1 - 0.021 14.0 0.0 0.17 11.1 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase I specific initiation factor Apt1 PF10351.4 EFW98677.1 - 0.47 9.2 8.9 0.99 8.1 6.2 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Nop14 PF04147.7 EFW98677.1 - 1.4 6.7 43.9 0.016 13.1 13.5 2.3 2 0 0 2 2 2 0 Nop14-like family MIP-T3 PF10243.4 EFW98678.1 - 0.049 12.1 0.2 0.049 12.1 0.2 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF515 PF04415.7 EFW98679.1 - 4.8 5.3 8.3 3.2 5.9 4.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF515) zinc_ribbon_6 PF14599.1 EFW98680.1 - 2.6e-25 87.9 0.4 2.6e-25 87.9 0.2 3.8 3 2 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.7 EFW98680.1 - 1.8e-14 53.6 22.0 1.8e-14 53.6 15.2 3.3 3 0 0 3 3 3 2 CHY zinc finger zf-RING_2 PF13639.1 EFW98680.1 - 6.6e-07 29.0 7.0 6.6e-07 29.0 4.8 3.3 4 1 0 4 4 4 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFW98680.1 - 9.1e-06 25.2 8.0 9.1e-06 25.2 5.6 4.7 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFW98680.1 - 0.0045 16.6 11.7 0.0045 16.6 8.1 4.4 4 2 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFW98680.1 - 0.0046 16.9 9.1 0.0046 16.9 6.3 4.8 3 2 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2_4 PF13894.1 EFW98680.1 - 0.22 11.9 0.1 0.22 11.9 0.0 5.4 6 1 0 6 6 6 0 C2H2-type zinc finger WD40 PF00400.27 EFW98681.1 - 3.4e-18 64.7 18.3 8.3e-07 28.6 0.1 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFW98681.1 - 0.0027 16.5 0.2 0.082 11.6 0.1 2.4 2 0 0 2 2 2 1 Nup133 N terminal like MraZ PF02381.13 EFW98681.1 - 0.0068 16.1 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 2 MraZ protein TFIIF_alpha PF05793.7 EFW98681.1 - 0.15 10.4 13.9 0.21 9.9 9.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.7 EFW98681.1 - 2.6 5.8 10.5 3.3 5.5 7.3 1.1 1 0 0 1 1 1 0 Nop14-like family FAD_binding_3 PF01494.14 EFW98682.1 - 9.3e-09 34.7 0.2 0.001 18.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 EFW98682.1 - 2.7e-06 27.3 0.2 6.5e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFW98682.1 - 0.00015 22.0 1.0 0.00033 21.0 0.3 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 EFW98682.1 - 0.0059 16.3 0.0 0.0084 15.8 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_2 PF07992.9 EFW98682.1 - 0.0064 16.3 0.2 0.0099 15.7 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFW98682.1 - 0.0077 15.1 0.2 0.01 14.7 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFW98682.1 - 0.0097 14.8 0.1 0.28 10.0 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 EFW98682.1 - 0.015 15.0 0.2 0.034 13.9 0.1 1.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EFW98682.1 - 0.016 15.3 0.2 0.017 15.1 0.1 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFW98682.1 - 0.027 13.3 1.5 0.037 12.8 0.6 1.6 1 1 1 2 2 2 0 FAD binding domain Thi4 PF01946.12 EFW98682.1 - 0.081 11.9 0.1 0.16 11.0 0.1 1.5 1 1 0 1 1 1 0 Thi4 family MFS_1 PF07690.11 EFW98683.1 - 1.1e-11 44.0 17.4 1.3e-11 43.8 12.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFW98683.1 - 4.9e-07 28.6 0.2 5.5e-07 28.5 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 EFW98683.1 - 0.0018 16.7 0.6 0.0023 16.4 0.4 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein DUF3816 PF12822.2 EFW98683.1 - 8.4 6.2 13.6 1.1 9.1 2.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3816) His_Phos_2 PF00328.17 EFW98684.1 - 8.2e-09 35.2 0.0 0.0012 18.3 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) MR_MLE_C PF13378.1 EFW98685.1 - 0.088 12.7 0.0 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Enolase C-terminal domain-like Zn_clus PF00172.13 EFW98686.1 - 9.5e-05 22.2 9.2 9.5e-05 22.2 6.4 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.8 EFW98686.1 - 0.17 11.9 2.2 0.31 11.1 1.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region KAR9 PF08580.5 EFW98686.1 - 2.6 6.1 4.7 3.5 5.8 3.3 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Fungal_trans PF04082.13 EFW98687.1 - 2.6e-29 101.8 0.0 6.2e-29 100.6 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW98687.1 - 6.2e-09 35.6 8.7 9.7e-09 35.0 6.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BAF1_ABF1 PF04684.8 EFW98687.1 - 0.54 9.0 10.1 1.1 8.0 7.0 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2076 PF09849.4 EFW98688.1 - 7.5e-10 39.2 7.3 8.6e-10 39.0 5.1 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 EFW98688.1 - 0.00045 20.0 3.7 0.00064 19.5 2.6 1.3 1 0 0 1 1 1 1 CHCH domain Gly-zipper_YMGG PF13441.1 EFW98688.1 - 0.32 10.5 4.6 0.54 9.8 3.2 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Nucleoporin_FG PF13634.1 EFW98688.1 - 9.3 6.5 16.1 15 5.8 11.2 1.4 1 1 0 1 1 1 0 Nucleoporin FG repeat region Hus1 PF04005.7 EFW98689.1 - 0.099 11.5 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Hus1-like protein 6PF2K PF01591.13 EFW98690.1 - 2.3e-67 226.3 0.0 1.8e-47 161.3 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EFW98690.1 - 3e-25 89.1 0.1 3.1e-24 85.8 0.0 2.5 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EFW98690.1 - 8.1e-07 29.0 0.0 7.5e-05 22.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFW98690.1 - 0.0061 17.3 0.1 0.032 15.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain CARD PF00619.16 EFW98690.1 - 0.012 15.4 0.4 0.039 13.7 0.3 1.9 1 1 0 1 1 1 0 Caspase recruitment domain KTI12 PF08433.5 EFW98690.1 - 0.017 14.3 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 EFW98690.1 - 0.12 11.4 0.0 0.49 9.4 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin Cpn60_TCP1 PF00118.19 EFW98693.1 - 3.8e-116 388.5 8.7 4.9e-116 388.2 6.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PEMT PF04191.8 EFW98694.1 - 9.9e-57 189.5 7.5 1.8e-35 121.2 0.7 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase TMF_DNA_bd PF12329.3 EFW98694.1 - 0.031 14.0 2.5 0.081 12.7 1.7 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.3 EFW98694.1 - 0.093 12.4 3.1 0.21 11.2 2.2 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Mnd1 PF03962.10 EFW98694.1 - 0.22 11.1 1.1 0.53 9.9 0.8 1.5 1 0 0 1 1 1 0 Mnd1 family bZIP_1 PF00170.16 EFW98694.1 - 0.24 11.4 2.0 0.59 10.1 1.4 1.7 1 0 0 1 1 1 0 bZIP transcription factor UPF0242 PF06785.6 EFW98694.1 - 1.5 7.4 2.4 2.4 6.7 1.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) PUF PF00806.14 EFW98695.1 - 6.1e-56 182.8 10.3 2.9e-07 29.5 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat ALS_ss_C PF10369.4 EFW98695.1 - 0.063 12.9 0.1 2.4 7.9 0.0 2.6 2 0 0 2 2 2 0 Small subunit of acetolactate synthase DUF1043 PF06295.7 EFW98697.1 - 0.17 11.4 0.1 0.38 10.3 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) DUF4106 PF13388.1 EFW98698.1 - 0.051 12.5 0.2 0.081 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Pyr_redox_2 PF07992.9 EFW98699.1 - 5.4e-15 55.8 0.3 7.8e-15 55.2 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFW98699.1 - 7.9e-12 45.4 0.1 2e-09 37.7 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFW98699.1 - 0.00013 21.0 0.0 0.002 17.1 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 EFW98699.1 - 0.00027 21.0 0.2 0.058 13.4 0.0 2.9 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFW98699.1 - 0.84 8.4 9.5 0.43 9.4 0.0 3.0 3 1 1 4 4 4 0 FAD dependent oxidoreductase TIP49 PF06068.8 EFW98700.1 - 3.7e-174 579.0 3.7 4.4e-174 578.8 2.6 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 EFW98700.1 - 3.9e-09 36.7 0.5 7.6e-06 26.1 0.0 3.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFW98700.1 - 1.9e-08 33.6 0.5 1.1e-05 24.5 0.0 2.9 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 EFW98700.1 - 1.5e-06 27.3 0.6 2.6e-06 26.5 0.4 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.1 EFW98700.1 - 1.4e-05 25.1 0.0 0.00064 19.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFW98700.1 - 0.00035 20.7 0.0 0.27 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 EFW98700.1 - 0.0025 17.0 1.0 0.022 13.8 0.3 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 EFW98700.1 - 0.0038 17.1 0.0 1.4 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 EFW98700.1 - 0.0041 16.6 0.1 1.1 8.7 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.1 EFW98700.1 - 0.0051 16.2 0.3 0.012 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFW98700.1 - 0.015 15.0 1.1 0.046 13.4 0.5 2.1 1 1 0 1 1 1 0 Part of AAA domain AAA_28 PF13521.1 EFW98700.1 - 0.016 15.1 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFW98700.1 - 0.06 13.6 0.0 0.35 11.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EFW98700.1 - 0.062 12.3 0.4 0.13 11.3 0.3 1.5 1 0 0 1 1 1 0 Zeta toxin SprB PF13573.1 EFW98700.1 - 0.14 11.7 0.1 0.34 10.5 0.1 1.6 1 0 0 1 1 1 0 SprB repeat Chorismate_bind PF00425.13 EFW98701.1 - 7e-88 294.2 0.0 1.2e-87 293.5 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 EFW98701.1 - 1.8e-34 118.8 0.0 3.4e-34 117.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 EFW98701.1 - 1e-29 102.0 0.0 2.7e-29 100.7 0.0 1.7 1 0 0 1 1 1 1 GMP synthase C terminal domain Anth_synt_I_N PF04715.8 EFW98701.1 - 7.9e-29 100.4 0.1 1.1e-24 87.0 0.0 3.3 3 0 0 3 3 3 1 Anthranilate synthase component I, N terminal region NAD_synthase PF02540.12 EFW98701.1 - 3e-10 39.4 0.1 1.7e-06 27.1 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 EFW98701.1 - 4.7e-06 26.1 0.0 1.5e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 Peptidase C26 Asn_synthase PF00733.16 EFW98701.1 - 0.00016 21.3 0.1 0.00028 20.4 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 EFW98701.1 - 0.0095 15.2 0.0 0.032 13.4 0.0 1.8 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EFW98701.1 - 0.025 13.1 0.1 0.044 12.3 0.1 1.4 1 0 0 1 1 1 0 tRNA methyl transferase ATP_bind_3 PF01171.15 EFW98701.1 - 0.066 12.7 0.0 0.62 9.5 0.0 2.1 2 0 0 2 2 2 0 PP-loop family PAPS_reduct PF01507.14 EFW98701.1 - 0.24 11.1 0.0 0.42 10.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family D123 PF07065.9 EFW98702.1 - 5.9e-75 252.1 0.0 1.3e-73 247.7 0.0 2.6 1 1 0 1 1 1 1 D123 COesterase PF00135.23 EFW98703.1 - 4.5e-68 230.2 0.0 7.5e-68 229.5 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family DUF3716 PF12511.3 EFW98704.1 - 6.4e-16 57.7 9.5 1e-15 57.0 6.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Asp_protease_2 PF13650.1 EFW98704.1 - 0.037 14.5 0.0 0.33 11.4 0.0 2.5 1 1 1 2 2 2 0 Aspartyl protease PG_binding_1 PF01471.13 EFW98705.1 - 0.0018 18.2 1.2 0.72 9.8 0.0 3.2 3 0 0 3 3 3 2 Putative peptidoglycan binding domain Tropomyosin_1 PF12718.2 EFW98705.1 - 0.016 15.0 1.6 0.038 13.8 1.1 1.6 1 0 0 1 1 1 0 Tropomyosin like PG_binding_3 PF09374.5 EFW98705.1 - 0.042 13.8 0.1 3.1 7.8 0.0 2.7 2 0 0 2 2 2 0 Predicted Peptidoglycan domain Spc7 PF08317.6 EFW98705.1 - 0.11 11.1 0.5 0.17 10.5 0.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.7 EFW98705.1 - 0.81 8.6 5.2 1.3 7.9 3.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 MbeD_MobD PF04899.7 EFW98705.1 - 3.4 7.6 6.3 27 4.7 4.3 2.2 1 1 0 1 1 1 0 MbeD/MobD like FAD-oxidase_C PF02913.14 EFW98707.1 - 4.5e-39 134.2 1.4 1.1e-38 132.9 0.9 1.8 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EFW98707.1 - 1e-37 128.6 0.1 2.2e-37 127.6 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain Na_Ca_ex PF01699.19 EFW98707.1 - 3.3e-22 78.6 31.4 1.7e-20 73.0 10.3 3.5 2 1 0 2 2 2 2 Sodium/calcium exchanger protein PSP1 PF04468.7 EFW98708.1 - 3.6e-30 103.8 0.8 3.6e-30 103.8 0.5 1.7 2 0 0 2 2 2 1 PSP1 C-terminal conserved region CAP_GLY PF01302.20 EFW98709.1 - 5.7e-21 73.9 0.9 8.4e-21 73.4 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 EFW98709.1 - 6.1e-17 61.6 0.0 9.3e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.18 EFW98709.1 - 0.068 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family HET PF06985.6 EFW98710.1 - 1.6e-30 106.1 0.2 3.1e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Utp11 PF03998.8 EFW98711.1 - 3.5e-48 164.5 29.3 4.8e-48 164.0 20.3 1.2 1 0 0 1 1 1 1 Utp11 protein ProSAAS PF07259.7 EFW98711.1 - 0.03 13.8 1.6 0.061 12.8 0.0 2.1 1 1 1 2 2 2 0 ProSAAS precursor CENP-B_dimeris PF09026.5 EFW98711.1 - 1.3 9.3 8.9 2 8.6 2.6 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AKAP7_NLS PF10469.4 EFW98712.1 - 2e-20 73.3 0.0 2.9e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Enkurin PF13864.1 EFW98712.1 - 0.17 12.0 0.1 0.17 12.0 0.1 1.6 2 0 0 2 2 2 0 Calmodulin-binding BatA PF07584.6 EFW98712.1 - 4.5 7.5 7.5 1.8 8.8 1.5 2.4 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF814 PF05670.8 EFW98713.1 - 8.6e-21 73.6 0.0 1.5e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Ribosomal_L3 PF00297.17 EFW98714.1 - 2.1e-115 384.6 8.0 2.5e-115 384.4 5.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 LIP PF03583.9 EFW98715.1 - 9.1e-69 231.8 0.5 1.3e-68 231.3 0.3 1.1 1 0 0 1 1 1 1 Secretory lipase RIO1 PF01163.17 EFW98716.1 - 3e-41 140.8 0.1 2.3e-29 102.0 0.0 2.1 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.6 EFW98716.1 - 5.1e-30 103.3 0.0 9.2e-30 102.5 0.0 1.4 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 EFW98716.1 - 8.5e-07 28.9 0.2 0.0051 16.5 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EFW98716.1 - 5.7e-05 22.2 0.1 0.00096 18.2 0.1 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_27 PF13463.1 EFW98716.1 - 0.064 13.5 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR_2 PF12802.2 EFW98716.1 - 0.081 12.5 0.4 0.64 9.7 0.1 2.6 3 1 0 3 3 3 0 MarR family Fungal_trans PF04082.13 EFW98717.1 - 8.2e-17 60.9 2.7 1.5e-16 60.1 1.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.1 EFW98717.1 - 2.3e-08 33.9 12.2 1.7e-05 24.8 4.1 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFW98717.1 - 6.4e-05 22.9 13.0 0.0041 17.3 3.6 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFW98717.1 - 0.00026 21.1 14.7 0.035 14.4 4.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type PMT PF02366.13 EFW98718.1 - 1.1e-76 257.4 16.5 1.1e-76 257.4 11.4 2.1 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EFW98718.1 - 1.1e-34 119.5 0.2 1.5e-34 119.1 0.1 1.2 1 0 0 1 1 1 1 MIR domain DUF2976 PF11190.3 EFW98718.1 - 0.012 15.0 3.6 0.061 12.8 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) WD40 PF00400.27 EFW98719.1 - 5.9e-17 60.8 1.7 1.2e-09 37.6 0.1 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.3 EFW98719.1 - 0.041 12.0 0.1 0.98 7.4 0.0 2.3 2 1 0 2 2 2 0 Nucleoporin Nup120/160 DUF867 PF05908.6 EFW98719.1 - 0.072 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF867) GRAB PF10375.4 EFW98720.1 - 0.013 15.1 0.7 0.013 15.1 0.5 2.9 3 0 0 3 3 3 0 GRIP-related Arf-binding domain Rootletin PF15035.1 EFW98720.1 - 0.02 14.8 56.0 0.039 13.9 9.9 3.8 1 1 3 4 4 4 0 Ciliary rootlet component, centrosome cohesion DUF3584 PF12128.3 EFW98720.1 - 0.024 11.9 49.6 0.034 11.4 34.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Prominin PF05478.6 EFW98720.1 - 0.18 9.3 11.4 0.087 10.3 1.5 2.3 2 0 0 2 2 2 0 Prominin ETRAMP PF09716.5 EFW98720.1 - 0.61 10.0 4.5 4.7 7.2 0.2 2.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) CENP-F_leu_zip PF10473.4 EFW98720.1 - 4.7 7.0 61.4 0.21 11.4 14.9 4.2 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Snapin_Pallidin PF14712.1 EFW98720.1 - 9.3 6.6 24.9 0.92 9.8 4.3 4.0 2 2 1 3 3 3 0 Snapin/Pallidin Pec_lyase_C PF00544.14 EFW98721.1 - 2e-19 69.8 5.6 3.3e-19 69.1 3.9 1.3 1 0 0 1 1 1 1 Pectate lyase MR_MLE_N PF02746.11 EFW98721.1 - 0.038 13.9 0.9 0.87 9.5 0.2 2.5 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain His_Phos_1 PF00300.17 EFW98722.1 - 9.7e-32 110.2 0.0 2.3e-31 109.0 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 EFW98722.1 - 0.0023 17.3 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PHD PF00628.24 EFW98723.1 - 4.1e-12 45.5 7.0 8.9e-12 44.5 4.9 1.6 1 0 0 1 1 1 1 PHD-finger Proteasome PF00227.21 EFW98724.1 - 1.9e-54 183.8 0.1 3e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFW98724.1 - 1.8e-12 46.3 0.1 1.8e-12 46.3 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Terminase_5 PF06056.7 EFW98724.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) IL6 PF00489.12 EFW98724.1 - 0.069 12.7 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Nol1_Nop2_Fmu PF01189.12 EFW98725.1 - 5.5e-101 337.6 0.0 7.7e-101 337.1 0.0 1.2 1 0 0 1 1 1 1 NOL1/NOP2/sun family FtsJ PF01728.14 EFW98725.1 - 0.024 14.6 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 EFW98725.1 - 0.028 14.9 0.3 0.16 12.5 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Fibrillarin PF01269.12 EFW98725.1 - 0.2 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin zf-HIT PF04438.11 EFW98726.1 - 9.5e-11 41.1 11.5 1.4e-10 40.6 8.0 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.13 EFW98726.1 - 1.1e-05 25.1 10.2 1.9e-05 24.4 7.1 1.4 1 0 0 1 1 1 1 MYND finger PolC_DP2 PF03833.8 EFW98726.1 - 0.7 7.4 2.5 0.91 7.1 1.7 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-B_box PF00643.19 EFW98726.1 - 1.2 9.0 7.0 2 8.3 4.9 1.3 1 0 0 1 1 1 0 B-box zinc finger API5 PF05918.6 EFW98726.1 - 2.5 6.5 6.1 3.5 6.0 4.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) adh_short PF00106.20 EFW98727.1 - 3.5e-19 69.3 0.8 4.2e-19 69.0 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFW98727.1 - 4.6e-08 32.9 0.3 7.5e-08 32.2 0.1 1.5 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.10 EFW98727.1 - 0.0037 16.2 0.0 0.0047 15.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein VitK2_biosynth PF02621.9 EFW98727.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Menaquinone biosynthesis DUF221 PF02714.10 EFW98728.1 - 1.7e-104 349.2 24.5 1.7e-104 349.2 17.0 2.3 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFW98728.1 - 7.2e-37 126.3 2.5 7.2e-37 126.3 1.7 3.3 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EFW98728.1 - 1.1e-16 60.5 0.0 2.3e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 EFW98728.1 - 3.7e-11 43.3 7.5 1.1e-05 25.8 2.5 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF4463) Cytochrom_B561 PF03188.11 EFW98729.1 - 3e-15 56.2 3.7 3e-15 56.2 2.6 1.9 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 PepSY_TM_1 PF13172.1 EFW98729.1 - 0.13 12.0 0.0 0.13 12.0 0.0 3.8 4 0 0 4 4 4 0 PepSY-associated TM helix DUF2427 PF10348.4 EFW98729.1 - 0.13 11.8 8.9 0.16 11.5 1.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) PepSY_TM_3 PF13706.1 EFW98729.1 - 0.26 10.7 0.0 0.26 10.7 0.0 3.8 5 0 0 5 5 5 0 PepSY-associated TM helix ATP1G1_PLM_MAT8 PF02038.11 EFW98729.1 - 8 5.5 6.0 6.7 5.8 0.0 2.8 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family Pkinase PF00069.20 EFW98730.1 - 5.1e-58 196.2 0.0 6.2e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW98730.1 - 1.7e-35 122.3 0.0 2.8e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW98730.1 - 5.8e-08 32.0 0.0 8.6e-08 31.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like SSI PF00720.12 EFW98731.1 - 0.054 13.4 0.1 0.069 13.0 0.1 1.1 1 0 0 1 1 1 0 Subtilisin inhibitor-like CRM1_C PF08767.6 EFW98732.1 - 1.9e-129 431.1 1.2 1.9e-129 431.1 0.8 3.5 5 0 0 5 5 5 1 CRM1 C terminal Xpo1 PF08389.7 EFW98732.1 - 1.1e-40 138.9 7.4 1.1e-40 138.9 5.1 3.4 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.14 EFW98732.1 - 2.6e-13 49.6 0.1 1.3e-12 47.4 0.1 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain RNase_T PF00929.19 EFW98733.1 - 4.6e-19 69.2 0.0 1.6e-18 67.5 0.0 1.7 1 1 0 1 1 1 1 Exonuclease ILVD_EDD PF00920.16 EFW98733.1 - 0.067 11.5 0.1 0.088 11.2 0.0 1.1 1 0 0 1 1 1 0 Dehydratase family HET PF06985.6 EFW98735.1 - 1e-35 122.8 0.9 1.8e-35 122.0 0.6 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ZZ PF00569.12 EFW98735.1 - 5.1e-08 32.3 6.2 9.6e-08 31.4 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Proteasome PF00227.21 EFW98737.1 - 1.4e-55 187.5 0.0 5.4e-32 110.6 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.4 EFW98737.1 - 2.1e-11 42.9 0.3 4.4e-11 41.8 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RhoGAP PF00620.22 EFW98738.1 - 2.7e-46 156.9 1.7 3.2e-46 156.7 0.0 2.0 3 0 0 3 3 3 1 RhoGAP domain LIM PF00412.17 EFW98738.1 - 6.5e-14 51.7 18.0 3.2e-09 36.6 1.7 2.4 2 0 0 2 2 2 2 LIM domain DASH_Hsk3 PF08227.6 EFW98738.1 - 0.5 10.5 2.9 8.8 6.6 0.1 2.8 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Zn-ribbon_8 PF09723.5 EFW98738.1 - 1.2 9.1 18.6 0.39 10.6 1.0 4.1 4 0 0 4 4 4 0 Zinc ribbon domain Desulfoferrod_N PF06397.7 EFW98738.1 - 1.3 8.4 9.8 12 5.3 0.6 3.5 2 1 1 3 3 3 0 Desulfoferrodoxin, N-terminal domain CCDC155 PF14662.1 EFW98738.1 - 1.7 8.2 22.8 1.1 8.8 12.7 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 zinc_ribbon_2 PF13240.1 EFW98738.1 - 2 7.9 9.5 2.9 7.4 0.0 4.3 4 1 0 4 4 4 0 zinc-ribbon domain Macoilin PF09726.4 EFW98738.1 - 2.6 6.2 29.1 1.3e+02 0.5 20.1 2.2 1 1 0 1 1 1 0 Transmembrane protein SlyX PF04102.7 EFW98738.1 - 3.7 7.9 12.5 0.16 12.3 0.8 3.3 2 1 0 2 2 2 0 SlyX V_ATPase_I PF01496.14 EFW98738.1 - 8.2 4.1 6.8 12 3.5 4.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DcpS_C PF11969.3 EFW98739.1 - 1.3e-12 47.9 0.8 7.3e-12 45.5 0.6 1.9 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 EFW98739.1 - 0.0022 18.4 3.9 0.036 14.6 2.7 2.3 1 1 0 1 1 1 1 HIT domain DUF2024 PF09630.5 EFW98739.1 - 0.04 13.6 0.2 0.14 11.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) Zn_clus PF00172.13 EFW98740.1 - 8.2e-08 32.0 8.3 1.4e-07 31.3 5.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFW98740.1 - 0.00027 19.6 0.6 0.00051 18.7 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ferric_reduct PF01794.14 EFW98741.1 - 3.6e-16 59.3 7.9 1e-15 57.9 5.5 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EFW98741.1 - 3.8e-14 52.4 0.0 8.7e-14 51.2 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EFW98741.1 - 1.2e-13 51.2 0.0 2.5e-09 37.2 0.0 2.9 3 0 0 3 3 3 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EFW98741.1 - 0.00092 19.7 0.1 0.071 13.6 0.0 3.1 4 0 0 4 4 4 1 Oxidoreductase NAD-binding domain DUF4405 PF14358.1 EFW98741.1 - 5.4 7.2 10.3 0.24 11.5 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) TPR_12 PF13424.1 EFW98742.1 - 2.6e-16 59.3 13.0 7.6e-08 32.1 3.0 4.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.1 EFW98742.1 - 4.9e-08 32.6 13.9 0.012 15.5 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat AAA_16 PF13191.1 EFW98742.1 - 0.00015 21.8 0.1 0.00015 21.8 0.0 3.2 3 1 1 4 4 4 1 AAA ATPase domain NB-ARC PF00931.17 EFW98742.1 - 0.0016 17.3 0.0 0.039 12.8 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain Arch_ATPase PF01637.13 EFW98742.1 - 0.0046 16.6 0.0 0.0093 15.6 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase IstB_IS21 PF01695.12 EFW98742.1 - 0.0054 16.1 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.7 EFW98742.1 - 0.035 13.7 0.0 0.97 9.0 0.0 2.9 3 0 0 3 3 3 0 NACHT domain AAA_22 PF13401.1 EFW98742.1 - 0.047 13.8 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Apc3 PF12895.2 EFW98742.1 - 0.73 10.0 4.5 2.1 8.5 0.9 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MFS_1 PF07690.11 EFW98743.1 - 1.5e-27 96.2 69.5 2.1e-20 72.7 22.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ITAM_Cys-rich PF10538.4 EFW98743.1 - 3.9 7.1 6.7 4.2 6.9 0.4 2.4 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif KH_1 PF00013.24 EFW98744.1 - 5.4e-41 138.0 11.9 5.7e-14 51.5 0.7 3.5 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EFW98744.1 - 1.2e-33 114.1 11.4 1.3e-11 43.8 1.3 3.7 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EFW98744.1 - 5.6e-12 45.0 6.4 0.0039 16.7 0.3 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EFW98744.1 - 9e-08 31.6 4.1 0.14 11.8 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 EFW98744.1 - 0.002 17.8 2.0 1.5 8.7 0.0 3.5 3 0 0 3 3 3 2 NusA-like KH domain dUTPase PF00692.14 EFW98744.1 - 0.12 11.8 0.0 18 4.7 0.0 3.0 3 0 0 3 3 3 0 dUTPase Nic96 PF04097.9 EFW98745.1 - 9.7e-196 651.5 0.0 1.3e-195 651.1 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Diphthamide_syn PF01866.12 EFW98746.1 - 1.5e-105 352.8 0.0 2e-105 352.4 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein DUF2890 PF11081.3 EFW98746.1 - 2.7 8.0 10.2 4.3 7.3 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Med3 PF11593.3 EFW98746.1 - 7 5.7 11.0 9.8 5.2 7.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal WD40 PF00400.27 EFW98747.1 - 3.8e-15 55.1 0.3 0.00011 21.8 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat LisH PF08513.6 EFW98747.1 - 6.7e-06 25.6 0.0 1.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 LisH eIF2A PF08662.6 EFW98747.1 - 0.0046 16.6 0.1 3 7.5 0.0 3.6 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A TruB_C PF09142.6 EFW98747.1 - 0.17 11.5 1.0 9 6.0 0.0 3.1 2 1 1 3 3 3 0 tRNA Pseudouridine synthase II, C terminal IKI3 PF04762.7 EFW98747.1 - 0.17 9.6 0.0 0.36 8.5 0.0 1.5 1 0 0 1 1 1 0 IKI3 family Transferase PF02458.10 EFW98749.1 - 6.5e-29 100.6 0.0 2.4e-17 62.4 0.0 3.4 3 1 0 3 3 3 2 Transferase family Sugar_tr PF00083.19 EFW98750.1 - 2.4e-41 141.7 20.8 3e-41 141.4 14.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFW98750.1 - 6.2e-17 61.3 24.1 1.1e-16 60.5 16.7 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily PUF PF00806.14 EFW98751.1 - 5.6e-28 94.8 4.3 7.1e-06 25.2 0.0 7.6 8 0 0 8 8 8 6 Pumilio-family RNA binding repeat MRP-S33 PF08293.6 EFW98751.1 - 1.5e-24 85.7 0.0 4e-24 84.3 0.0 1.8 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 tRNA-synt_2d PF01409.15 EFW98752.1 - 2.6e-49 167.6 0.0 5.3e-25 88.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 EFW98752.1 - 4.1e-24 84.5 0.0 8.1e-24 83.6 0.0 1.5 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF3811 PF11656.3 EFW98752.1 - 0.064 13.3 0.1 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 YjbD family (DUF3811) tRNA-synt_2 PF00152.15 EFW98752.1 - 0.2 10.3 0.5 0.68 8.6 0.0 2.0 3 0 0 3 3 3 0 tRNA synthetases class II (D, K and N) Aminotran_4 PF01063.14 EFW98753.1 - 6.7e-08 32.2 0.1 0.0037 16.7 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class IV P5CR_dimer PF14748.1 EFW98753.1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation DMRL_synthase PF00885.14 EFW98755.1 - 8.8e-45 151.9 0.0 1.1e-25 90.0 0.0 2.0 2 0 0 2 2 2 2 6,7-dimethyl-8-ribityllumazine synthase Gly-zipper_OmpA PF13436.1 EFW98756.1 - 0.0094 15.6 6.7 0.092 12.4 0.8 2.4 1 1 1 2 2 2 2 Glycine-zipper containing OmpA-like membrane domain DUF2530 PF10745.4 EFW98756.1 - 0.17 11.8 4.3 2.4 8.1 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Gly-zipper_Omp PF13488.1 EFW98756.1 - 0.2 11.3 14.2 3.5 7.3 9.7 2.3 1 1 1 2 2 2 0 Glycine zipper Rick_17kDa_Anti PF05433.10 EFW98756.1 - 0.2 11.3 16.7 10 5.9 11.6 2.4 1 1 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.1 EFW98756.1 - 0.88 9.1 12.7 3.4 7.2 8.8 2.0 1 1 0 1 1 1 0 YMGG-like Gly-zipper CLASP_N PF12348.3 EFW98758.1 - 0.00039 19.8 0.0 0.32 10.3 0.0 4.1 3 0 0 3 3 3 2 CLASP N terminal Vac14_Fab1_bd PF12755.2 EFW98758.1 - 0.0033 17.7 0.0 0.63 10.4 0.0 4.4 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT PF02985.17 EFW98758.1 - 0.008 16.1 26.1 0.19 11.8 0.0 9.8 11 0 0 11 11 11 3 HEAT repeat Skp1 PF01466.14 EFW98759.1 - 7.1e-40 134.9 2.2 1.1e-39 134.2 1.5 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 EFW98759.1 - 7.6e-18 64.3 0.0 1.8e-17 63.1 0.0 1.6 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF4375 PF14300.1 EFW98759.1 - 0.0045 16.9 0.2 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4375) DAO PF01266.19 EFW98760.1 - 1.2e-27 96.8 2.1 1.2e-27 96.7 0.4 1.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW98760.1 - 0.0008 19.3 0.1 0.0023 17.8 0.0 1.8 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFW98760.1 - 0.0015 18.8 0.1 0.56 10.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFW98760.1 - 0.0023 18.0 0.0 0.056 13.4 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFW98760.1 - 0.0036 17.2 0.0 3.4 7.4 0.1 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFW98760.1 - 0.0038 15.9 0.1 0.92 8.0 0.1 2.3 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.1 EFW98760.1 - 0.066 12.9 0.5 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Mqo PF06039.10 EFW98760.1 - 0.23 9.5 0.0 0.34 9.0 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Pkinase PF00069.20 EFW98761.1 - 4.1e-18 65.4 0.0 3.3e-08 32.9 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain FHA PF00498.21 EFW98761.1 - 2e-09 37.4 1.0 6.4e-09 35.8 0.1 2.1 2 0 0 2 2 2 1 FHA domain Pkinase_Tyr PF07714.12 EFW98761.1 - 9.9e-06 24.7 0.0 0.059 12.4 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase SNARE PF05739.14 EFW98762.1 - 1.9e-08 33.8 4.0 3.7e-08 32.9 2.8 1.5 1 0 0 1 1 1 1 SNARE domain DUF1876 PF08962.6 EFW98762.1 - 0.32 10.8 2.9 16 5.3 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1876) HrpB7 PF09486.5 EFW98762.1 - 1.4 8.8 9.0 2.8 7.8 1.2 3.2 2 2 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) RRM_1 PF00076.17 EFW98763.1 - 6.9e-15 54.4 0.5 2.4e-14 52.7 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98763.1 - 1.5e-10 40.9 0.0 3.1e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW98763.1 - 2.7e-08 33.5 0.0 7.2e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 EFW98763.1 - 0.001 17.6 37.8 0.001 17.6 26.2 2.1 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 ABC2_membrane PF01061.19 EFW98765.1 - 5.5e-44 149.8 24.2 7e-40 136.4 9.0 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 EFW98765.1 - 9.3e-33 113.4 0.0 2e-22 79.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 EFW98765.1 - 3.7e-29 100.4 1.1 3.5e-26 90.8 0.1 2.5 2 0 0 2 2 2 2 CDR ABC transporter SMC_N PF02463.14 EFW98765.1 - 3.5e-07 29.6 0.0 0.046 12.9 0.0 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EFW98765.1 - 0.0008 18.6 0.0 0.0016 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 EFW98765.1 - 0.0015 17.9 0.2 0.0056 16.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFW98765.1 - 0.0033 17.4 0.4 0.0088 16.0 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 EFW98765.1 - 0.0069 15.8 0.1 0.018 14.5 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 EFW98765.1 - 0.0076 16.2 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 EFW98765.1 - 0.021 14.4 0.2 0.047 13.3 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 EFW98765.1 - 0.03 14.1 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFW98765.1 - 0.037 14.1 0.0 0.081 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFW98765.1 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 EFW98765.1 - 0.052 13.4 0.0 0.47 10.4 0.0 2.3 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.7 EFW98765.1 - 0.071 12.7 0.0 0.3 10.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.1 EFW98765.1 - 0.079 13.7 0.0 0.2 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 EFW98765.1 - 0.13 11.7 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 EFW98765.1 - 0.15 11.5 0.1 0.42 10.1 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 EFW98765.1 - 0.16 11.4 0.1 0.33 10.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain Tom37_C PF11801.3 EFW98766.1 - 1.1e-21 77.4 0.0 1.1e-20 74.1 0.0 2.0 1 1 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.4 EFW98766.1 - 7.5e-16 58.1 0.0 3.2e-15 56.1 0.0 2.1 2 1 0 2 2 2 1 Outer mitochondrial membrane transport complex protein F-box PF00646.28 EFW98767.1 - 0.00018 21.0 1.0 0.00018 21.0 0.7 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EFW98767.1 - 0.012 15.3 0.1 0.047 13.4 0.0 2.1 1 0 0 1 1 1 0 F-box-like p450 PF00067.17 EFW98768.1 - 9e-45 153.0 0.0 1.2e-44 152.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RNA_pol_Rpb5_C PF01191.14 EFW98768.1 - 0.13 11.8 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain FMN_dh PF01070.13 EFW98769.1 - 6.3e-93 311.4 0.2 1.4e-92 310.3 0.1 1.5 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EFW98769.1 - 1.5e-16 59.9 0.0 4e-16 58.5 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EFW98769.1 - 7e-06 25.1 0.1 1.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.9 EFW98769.1 - 0.002 17.2 0.8 0.099 11.6 0.1 2.2 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.20 EFW98769.1 - 0.0048 15.8 0.8 0.0097 14.8 0.0 1.8 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain DGF-1_5 PF11038.3 EFW98769.1 - 0.0063 15.7 0.1 0.014 14.6 0.1 1.5 1 0 0 1 1 1 1 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 ImcF-related_N PF14331.1 EFW98769.1 - 0.04 12.8 0.1 0.069 12.0 0.1 1.3 1 0 0 1 1 1 0 ImcF-related N-terminal domain Hamartin PF04388.7 EFW98770.1 - 5.3e-36 124.5 7.1 5.3e-36 124.5 4.9 1.8 2 0 0 2 2 2 1 Hamartin protein GAS PF13851.1 EFW98770.1 - 2.2 7.3 39.8 0.9 8.6 14.5 2.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding PIG-U PF06728.8 EFW98771.1 - 1e-125 419.5 27.7 1.2e-125 419.3 19.2 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mannosyl_trans PF05007.8 EFW98771.1 - 9.8e-06 25.3 0.8 9.8e-06 25.3 0.5 1.7 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) AAA_12 PF13087.1 EFW98772.1 - 1.3e-07 31.2 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain MHC_II_alpha PF00993.15 EFW98772.1 - 0.086 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain DUF2415 PF10313.4 EFW98773.1 - 2.5e-11 43.0 0.0 6.9e-11 41.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) ECH PF00378.15 EFW98774.1 - 6.8e-66 221.8 0.1 8.4e-66 221.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family PilI PF10623.4 EFW98774.1 - 0.042 13.7 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 Plasmid conjugative transfer protein PilI DUF4098 PF13345.1 EFW98775.1 - 2.2e-06 27.5 9.8 7.4e-06 25.8 0.1 4.2 3 1 1 4 4 4 2 Domain of unknown function (DUF4098) Blt1 PF12754.2 EFW98776.1 - 4.5e-29 102.0 0.0 8.8e-29 101.0 0.0 1.5 1 1 0 1 1 1 1 Cell-cycle control medial ring component ubiquitin PF00240.18 EFW98776.1 - 0.012 15.0 0.1 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family ATP-synt_ab PF00006.20 EFW98777.1 - 1.6e-60 204.2 0.0 2.5e-60 203.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.18 EFW98777.1 - 7.9e-24 83.6 0.5 2.3e-23 82.1 0.1 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab_C PF00306.22 EFW98777.1 - 1.2e-23 83.6 0.3 2.4e-23 82.7 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain Alpha-amylase_C PF02806.13 EFW98777.1 - 2.7e-20 72.3 0.0 8e-20 70.7 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 EFW98777.1 - 2e-17 63.5 0.1 1.8e-13 50.5 0.1 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.13 EFW98777.1 - 9.8e-17 60.7 0.0 1.9e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Arch_ATPase PF01637.13 EFW98777.1 - 0.036 13.7 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase AAA_25 PF13481.1 EFW98777.1 - 0.038 13.4 0.2 0.2 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EFW98777.1 - 0.041 13.0 0.1 0.096 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MobB PF03205.9 EFW98777.1 - 0.061 13.0 0.1 3.2 7.4 0.0 2.9 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 EFW98777.1 - 0.068 13.3 0.1 2.5 8.2 0.0 3.0 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EFW98777.1 - 0.072 12.7 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain KaiC PF06745.8 EFW98777.1 - 0.11 11.5 0.1 0.21 10.6 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.1 EFW98777.1 - 0.15 12.0 0.1 0.85 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 EFW98777.1 - 0.16 12.1 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF2012 PF09430.5 EFW98779.1 - 1.7e-09 37.5 0.0 2.7e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Serglycin PF04360.7 EFW98779.1 - 1.1 8.9 3.6 1.9 8.2 2.5 1.4 1 0 0 1 1 1 0 Serglycin HET PF06985.6 EFW98780.1 - 4e-27 95.0 1.1 7.5e-27 94.1 0.8 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) CMS1 PF14617.1 EFW98781.1 - 7.2e-80 267.6 0.2 9.1e-80 267.3 0.1 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.24 EFW98781.1 - 8.6e-05 22.0 0.0 0.00023 20.6 0.0 1.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_60s PF00428.14 EFW98781.1 - 0.18 12.1 1.0 0.39 11.1 0.7 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein PAS_3 PF08447.6 EFW98782.1 - 3.1e-11 43.2 0.0 3.2e-09 36.7 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.1 EFW98782.1 - 5.8e-11 42.6 0.0 1.5e-05 25.3 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.19 EFW98782.1 - 1.1e-09 38.0 0.0 0.00015 21.5 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.1 EFW98782.1 - 2.6e-06 27.3 0.0 9.4e-06 25.5 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.5 EFW98782.1 - 4.1e-05 23.5 0.0 0.0079 16.2 0.0 2.5 2 0 0 2 2 2 1 PAS fold Paf1 PF03985.8 EFW98783.1 - 3.5e-52 177.6 0.0 1.9e-45 155.4 0.0 2.0 2 0 0 2 2 2 2 Paf1 Pkinase PF00069.20 EFW98784.1 - 9.5e-13 47.8 0.0 2.8e-08 33.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFW98784.1 - 7.8e-05 21.8 0.0 0.00011 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF572 PF04502.8 EFW98784.1 - 0.43 9.7 3.4 0.63 9.1 2.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) UCH PF00443.24 EFW98785.1 - 7.6e-38 130.1 0.0 1.3e-31 109.7 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFW98785.1 - 4.2e-12 46.1 0.3 1.3e-07 31.3 0.0 3.4 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUF4611 PF15387.1 EFW98786.1 - 0.21 11.7 7.0 0.55 10.4 4.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.6 EFW98786.1 - 4.8 4.9 17.2 0.11 10.3 2.2 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Bystin PF05291.6 EFW98788.1 - 3.4e-113 377.5 0.0 4.3e-113 377.2 0.0 1.1 1 0 0 1 1 1 1 Bystin Rrn6 PF10214.4 EFW98789.1 - 1.5e-59 201.9 0.0 3.6e-44 151.0 0.0 2.1 2 0 0 2 2 2 2 RNA polymerase I-specific transcription-initiation factor PITH PF06201.8 EFW98789.1 - 7.8e-40 136.1 0.0 1.3e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 PITH domain Coa1 PF08695.5 EFW98790.1 - 1.1e-37 128.0 0.0 2.3e-37 127.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Trypsin_2 PF13365.1 EFW98790.1 - 3e-05 23.9 0.0 0.00019 21.3 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_C3 PF00548.15 EFW98790.1 - 0.28 10.9 0.8 0.52 10.0 0.5 1.4 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) Aldolase_II PF00596.16 EFW98791.1 - 3.5e-37 127.7 0.7 4.8e-37 127.3 0.5 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ATP-grasp_2 PF08442.5 EFW98793.1 - 1.5e-77 259.5 3.0 1.7e-77 259.4 0.6 1.9 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.14 EFW98793.1 - 2.2e-24 85.7 0.9 4.2e-24 84.8 0.6 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.1 EFW98793.1 - 1.3e-06 27.7 0.2 4.3e-06 26.0 0.1 1.9 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 EFW98793.1 - 0.00011 21.8 0.8 0.005 16.4 0.1 2.6 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.1 EFW98793.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain PRP38 PF03371.10 EFW98794.1 - 1.8e-61 206.7 0.0 2.2e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Ank_2 PF12796.2 EFW98795.1 - 1.1e-16 60.9 0.1 1.7e-06 28.2 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFW98795.1 - 7.9e-13 48.1 1.6 1.6e-07 31.3 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 EFW98795.1 - 1.8e-10 40.0 3.6 1.4e-06 27.8 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 EFW98795.1 - 7.7e-10 39.0 0.3 0.0019 18.6 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98795.1 - 6.7e-06 25.8 1.0 0.00097 19.1 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeat Ribosom_S12_S23 PF00164.20 EFW98796.1 - 9.8e-41 138.0 0.4 1.1e-40 137.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ank_2 PF12796.2 EFW98798.1 - 2.3e-49 165.6 4.4 1.5e-15 57.2 0.0 4.2 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) SPX PF03105.14 EFW98798.1 - 5.1e-30 105.1 8.8 2.2e-17 63.7 0.6 2.2 1 1 1 2 2 2 2 SPX domain Ank PF00023.25 EFW98798.1 - 1.4e-22 78.2 7.1 4.2e-06 26.3 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.1 EFW98798.1 - 2e-19 69.5 4.5 4.9e-11 42.8 0.0 5.4 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98798.1 - 5.1e-15 54.0 5.1 0.00028 20.8 0.0 6.5 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.1 EFW98798.1 - 3.6e-14 52.4 10.6 0.00072 19.7 0.0 6.7 2 1 4 6 6 6 5 Ankyrin repeats (many copies) GDPD PF03009.12 EFW98798.1 - 1.9e-10 40.6 0.0 6.1e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family DASH_Dad2 PF08654.5 EFW98799.1 - 9.6e-31 105.8 5.1 2e-30 104.7 3.5 1.5 1 1 0 1 1 1 1 DASH complex subunit Dad2 Baculo_PEP_C PF04513.7 EFW98799.1 - 0.078 12.8 3.4 0.1 12.3 2.4 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.7 EFW98799.1 - 0.14 12.4 2.3 0.29 11.4 1.6 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Arm PF00514.18 EFW98800.1 - 2.3e-10 39.9 15.7 0.054 13.3 0.2 9.2 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EFW98800.1 - 3.7e-06 27.1 12.7 0.8 10.0 0.2 5.6 4 1 1 5 5 5 2 HEAT repeats V-ATPase_H_N PF03224.9 EFW98800.1 - 0.0043 16.2 0.0 0.31 10.1 0.0 2.5 2 0 0 2 2 2 1 V-ATPase subunit H Ric8 PF10165.4 EFW98800.1 - 0.019 13.7 0.7 5.5 5.7 0.1 2.7 3 0 0 3 3 3 0 Guanine nucleotide exchange factor synembryn CENP-B_dimeris PF09026.5 EFW98800.1 - 0.024 14.8 11.0 0.71 10.1 3.5 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 EFW98800.1 - 0.06 12.9 4.1 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EFW98800.1 - 0.076 13.3 10.6 3.6 7.9 0.2 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spt5_N PF11942.3 EFW98800.1 - 0.079 13.5 10.4 0.86 10.2 3.2 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal BAF1_ABF1 PF04684.8 EFW98800.1 - 0.1 11.4 3.7 0.23 10.2 2.6 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor HEAT PF02985.17 EFW98800.1 - 0.11 12.5 21.3 4.5 7.6 0.0 8.4 10 0 0 10 10 9 0 HEAT repeat FAM176 PF14851.1 EFW98800.1 - 0.36 10.4 3.5 2.4 7.8 0.7 2.3 2 0 0 2 2 2 0 FAM176 family Nucleoplasmin PF03066.10 EFW98800.1 - 1.1 8.7 12.1 2.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Nucleoplasmin HEAT_EZ PF13513.1 EFW98800.1 - 1.6 9.3 22.8 2.4 8.7 0.1 7.3 6 1 1 7 7 6 0 HEAT-like repeat Nop14 PF04147.7 EFW98800.1 - 2.5 5.8 7.7 0.4 8.5 1.5 1.9 2 0 0 2 2 2 0 Nop14-like family SbcCD_C PF13558.1 EFW98801.1 - 1.8e-11 43.8 0.0 7.1e-11 41.8 0.0 2.2 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.1 EFW98801.1 - 0.00027 21.0 0.1 0.0021 18.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 EFW98801.1 - 0.00042 19.6 10.8 0.00042 19.6 7.5 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_2 PF07724.9 EFW98802.1 - 8.1e-33 113.7 0.0 2.3e-32 112.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 EFW98802.1 - 6.3e-13 49.0 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 EFW98802.1 - 3.9e-09 36.2 0.0 8.2e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 EFW98802.1 - 2.4e-06 27.2 0.0 5.5e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EFW98802.1 - 0.00018 22.2 0.5 0.00074 20.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EFW98802.1 - 0.00079 18.8 0.8 0.0063 15.9 0.0 2.3 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_22 PF13401.1 EFW98802.1 - 0.00084 19.4 0.1 0.0041 17.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFW98802.1 - 0.0011 18.9 0.0 0.0024 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain MCM PF00493.18 EFW98802.1 - 0.0013 17.6 0.0 0.0026 16.6 0.0 1.4 1 0 0 1 1 1 1 MCM2/3/5 family ResIII PF04851.10 EFW98802.1 - 0.0047 16.7 0.5 0.8 9.4 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_29 PF13555.1 EFW98802.1 - 0.0084 15.6 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFW98802.1 - 0.011 15.6 0.1 0.078 12.9 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain AAA_21 PF13304.1 EFW98802.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 EFW98802.1 - 0.025 13.6 0.0 0.035 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 EFW98802.1 - 0.035 13.5 0.0 7 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 EFW98802.1 - 0.085 12.0 0.0 0.27 10.3 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 EFW98802.1 - 0.087 12.3 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 EFW98803.1 - 5.7e-26 91.0 0.0 3.6e-13 49.3 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW98803.1 - 1.8e-20 72.5 0.1 3.6e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW98803.1 - 0.00015 21.6 0.1 0.01 15.6 0.0 3.0 2 2 0 2 2 2 1 Type III restriction enzyme, res subunit Nop14 PF04147.7 EFW98803.1 - 0.0013 16.7 5.9 0.0013 16.7 4.1 3.0 3 0 0 3 3 3 1 Nop14-like family Use1 PF09753.4 EFW98803.1 - 0.99 8.7 10.8 2.6 7.4 7.5 1.6 1 0 0 1 1 1 0 Membrane fusion protein Use1 BMFP PF04380.8 EFW98805.1 - 0.047 13.8 0.2 0.3 11.2 0.0 2.3 2 0 0 2 2 2 0 Membrane fusogenic activity HMG_box PF00505.14 EFW98806.1 - 3.4e-06 27.2 0.0 9e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFW98806.1 - 0.00048 20.4 0.0 0.0018 18.5 0.0 2.0 1 0 0 1 1 1 1 HMG-box domain P_C PF06640.6 EFW98808.1 - 0.021 14.8 0.1 0.029 14.3 0.1 1.2 1 0 0 1 1 1 0 P protein C-terminus SMC_N PF02463.14 EFW98809.1 - 1.9e-70 236.5 0.0 5.4e-70 235.0 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EFW98809.1 - 1.7e-22 79.6 0.6 1e-21 77.0 0.1 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EFW98809.1 - 3.2e-13 50.3 0.5 2.1e-05 24.6 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EFW98809.1 - 6.3e-10 39.7 22.4 6.3e-10 39.7 15.5 6.3 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.1 EFW98809.1 - 0.0009 18.7 0.1 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 EFW98809.1 - 0.059 12.5 33.2 0.14 11.3 1.0 7.0 3 2 5 8 8 8 0 Reovirus sigma C capsid protein DUF4250 PF14056.1 EFW98809.1 - 0.066 12.9 0.3 0.76 9.5 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) HLH PF00010.21 EFW98810.1 - 8.7e-09 34.9 0.0 1.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Umbravirus_LDM PF04817.7 EFW98810.1 - 0.034 13.3 0.2 0.035 13.2 0.2 1.1 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family Vasculin PF15337.1 EFW98810.1 - 0.061 13.8 0.0 0.089 13.2 0.0 1.3 1 0 0 1 1 1 0 Vascular protein family Vasculin-like 1 DUF1542 PF07564.6 EFW98810.1 - 0.34 10.9 2.5 0.95 9.5 0.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Abhydrolase_5 PF12695.2 EFW98811.1 - 1.2e-05 25.1 0.2 3.8e-05 23.4 0.2 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFW98811.1 - 0.019 14.5 0.1 0.038 13.5 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.9 EFW98811.1 - 0.034 13.4 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) WD40 PF00400.27 EFW98813.1 - 4e-05 23.3 12.7 0.02 14.7 0.1 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat adh_short PF00106.20 EFW98814.1 - 7.6e-19 68.2 0.0 1.7e-18 67.0 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW98814.1 - 3.7e-05 23.6 0.0 5.4e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 EFW98814.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 EFW98814.1 - 0.003 17.5 0.0 0.0054 16.7 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFW98814.1 - 0.0073 15.7 0.0 0.029 13.8 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.5 EFW98814.1 - 0.034 13.7 0.1 0.18 11.4 0.1 2.2 1 1 0 1 1 1 0 KR domain Aldo_ket_red PF00248.16 EFW98815.1 - 1.1e-13 50.7 0.0 1.3e-06 27.4 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family NRPS PF08415.5 EFW98815.1 - 0.0015 18.2 0.9 0.077 12.7 0.1 3.3 3 1 1 4 4 4 1 Nonribosomal peptide synthase Peptidase_M24 PF00557.19 EFW98816.1 - 9.1e-47 159.3 0.1 1.1e-46 159.0 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-MYND PF01753.13 EFW98816.1 - 0.00015 21.5 2.4 0.00033 20.4 1.7 1.6 1 0 0 1 1 1 1 MYND finger Cpn60_TCP1 PF00118.19 EFW98817.1 - 5e-160 533.3 0.1 5.7e-160 533.1 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Aldedh PF00171.17 EFW98818.1 - 1e-87 294.4 0.0 1.3e-87 294.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PTPLA PF04387.9 EFW98819.1 - 6e-48 162.3 11.9 7e-47 158.9 5.6 2.3 1 1 1 2 2 2 2 Protein tyrosine phosphatase-like protein, PTPLA Glyco_hydro_16 PF00722.16 EFW98820.1 - 5.5e-13 48.6 0.0 8.9e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SRP9-21 PF05486.7 EFW98821.1 - 1e-22 79.6 0.0 1.4e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) DUF4195 PF13836.1 EFW98821.1 - 0.081 12.6 0.5 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4195) CBFD_NFYB_HMF PF00808.18 EFW98822.1 - 1.7e-15 56.8 0.1 3.8e-15 55.7 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFW98822.1 - 0.0015 18.6 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Glu_synthase PF01645.12 EFW98823.1 - 3.3e-160 533.0 0.1 7.3e-160 531.8 0.0 1.6 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.16 EFW98823.1 - 1.2e-139 465.0 0.0 1.6e-139 464.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 EFW98823.1 - 7.5e-119 396.2 0.0 1.3e-118 395.4 0.0 1.4 1 0 0 1 1 1 1 Glutamate synthase central domain GXGXG PF01493.14 EFW98823.1 - 1.3e-66 223.5 3.6 2.3e-66 222.6 2.5 1.4 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 EFW98823.1 - 6.4e-23 80.4 0.1 1.5e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 EFW98823.1 - 1.6e-17 64.0 0.0 7.1e-17 61.9 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFW98823.1 - 1.3e-10 41.6 0.2 0.00067 19.7 0.1 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFW98823.1 - 6.4e-09 35.7 0.1 2.7e-08 33.6 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFW98823.1 - 9.2e-08 32.3 0.1 0.00017 21.9 0.1 3.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 EFW98823.1 - 1.7e-06 27.3 0.3 3e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 EFW98823.1 - 1.6e-05 23.9 0.2 1.6e-05 23.9 0.2 2.6 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFW98823.1 - 3.4e-05 22.8 0.1 0.00018 20.5 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 EFW98823.1 - 5.5e-05 21.8 0.3 5.5e-05 21.8 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.2 EFW98823.1 - 0.00022 20.4 0.1 0.00053 19.1 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFW98823.1 - 0.00032 19.8 0.1 0.00067 18.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.1 EFW98823.1 - 0.00036 20.7 0.5 0.45 10.8 0.1 3.0 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 EFW98823.1 - 0.00052 19.6 0.0 0.0095 15.5 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.14 EFW98823.1 - 0.01 14.0 0.1 1 7.4 0.0 2.7 2 1 1 3 3 3 0 Flavin-binding monooxygenase-like NAD_Gly3P_dh_N PF01210.18 EFW98823.1 - 0.022 14.4 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Thi4 PF01946.12 EFW98823.1 - 0.025 13.7 0.1 0.025 13.7 0.1 2.7 4 0 0 4 4 3 0 Thi4 family NAD_binding_9 PF13454.1 EFW98823.1 - 0.03 14.1 0.1 0.23 11.2 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.17 EFW98823.1 - 0.033 13.0 2.0 0.067 12.0 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Shikimate_DH PF01488.15 EFW98823.1 - 0.073 13.1 0.1 20 5.2 0.0 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 EFW98823.1 - 0.13 11.4 0.2 1 8.4 0.0 2.3 3 0 0 3 3 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 EFW98823.1 - 0.14 11.7 0.1 0.44 10.1 0.0 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EFW98823.1 - 0.64 10.4 2.5 1.2 9.6 0.1 2.6 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent DIOX_N PF14226.1 EFW98824.1 - 2e-18 66.9 0.0 3.2e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFW98824.1 - 2.7e-17 62.8 0.0 4.7e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Myco_19_kDa PF05481.7 EFW98825.1 - 0.43 10.3 2.9 0.51 10.1 2.0 1.2 1 1 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen DUF3446 PF11928.3 EFW98825.1 - 1.7 8.9 8.2 3.7 7.7 5.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3446) Oxysterol_BP PF01237.13 EFW98826.1 - 5.2e-83 278.4 0.0 6e-83 278.2 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein PPTA PF01239.17 EFW98828.1 - 5.3e-06 25.5 8.0 0.0078 15.5 0.1 3.6 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat Glyco_transf_34 PF05637.7 EFW98829.1 - 2.1e-64 217.2 0.0 2.9e-64 216.8 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 EFW98829.1 - 0.032 13.5 0.0 0.068 12.4 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function, DUF273 zf-C2H2_4 PF13894.1 EFW98830.1 - 0.092 13.1 1.1 7.4 7.1 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger RRN7 PF11781.3 EFW98830.1 - 0.32 10.5 2.3 9.4 5.8 0.2 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2H2_4 PF13894.1 EFW98832.1 - 0.011 16.0 0.2 0.029 14.6 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFW98832.1 - 0.051 13.9 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type WD40 PF00400.27 EFW98833.1 - 1.4e-06 27.9 8.6 0.0001 22.0 0.0 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Condensation PF00668.15 EFW98834.1 - 2.8e-06 26.3 0.1 3e-06 26.2 0.1 1.0 1 0 0 1 1 1 1 Condensation domain Ank_2 PF12796.2 EFW98835.1 - 1.6e-15 57.1 0.3 1.9e-08 34.4 0.0 2.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFW98835.1 - 5.6e-11 41.6 0.2 0.00024 20.7 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 EFW98835.1 - 3.1e-06 27.2 0.1 0.00035 20.7 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98835.1 - 4.1e-06 26.5 0.0 0.043 14.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat vWA-TerF-like PF10138.4 EFW98835.1 - 1.4e-05 24.9 0.0 2.9e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 vWA found in TerF C terminus Ank_4 PF13637.1 EFW98835.1 - 0.002 18.6 0.2 0.016 15.6 0.1 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) PrkA PF06798.7 EFW98835.1 - 0.041 13.1 0.1 4.8 6.3 0.0 2.3 2 0 0 2 2 2 0 PrkA serine protein kinase C-terminal domain XRCC4 PF06632.7 EFW98836.1 - 9.6e-10 37.8 7.9 9.6e-10 37.8 5.5 2.1 1 1 1 2 2 2 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 NOA36 PF06524.7 EFW98836.1 - 0.05 12.8 5.7 0.068 12.4 4.0 1.1 1 0 0 1 1 1 0 NOA36 protein PEP-utilisers_N PF05524.8 EFW98836.1 - 0.84 9.4 8.4 0.15 11.8 2.8 2.0 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal ORC5_C PF14630.1 EFW98837.1 - 9.9e-69 231.7 0.0 3.5e-68 229.9 0.0 1.8 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 EFW98837.1 - 6.4e-11 42.5 2.7 2.7e-10 40.5 1.9 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFW98837.1 - 0.028 14.5 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 EFW98837.1 - 0.054 12.3 0.0 0.082 11.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein FGGY_C PF02782.11 EFW98839.1 - 3.6e-47 160.5 3.5 5.8e-47 159.8 2.4 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFW98839.1 - 9.1e-17 61.1 0.4 5.1e-15 55.4 0.3 3.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 EFW98839.1 - 0.0035 16.6 0.4 0.0062 15.8 0.0 1.8 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family DUF3209 PF11483.3 EFW98839.1 - 0.03 14.6 0.1 0.09 13.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) HMGL-like PF00682.14 EFW98840.1 - 2.3e-65 220.6 0.0 3.3e-65 220.0 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 EFW98840.1 - 5.8e-25 87.6 0.0 1.3e-24 86.4 0.0 1.7 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF1751 PF08551.5 EFW98841.1 - 7.6e-27 93.5 3.2 1.8e-26 92.3 2.2 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Cation_efflux PF01545.16 EFW98842.1 - 4.2e-28 98.2 13.7 5.3e-28 97.9 9.5 1.1 1 0 0 1 1 1 1 Cation efflux family Med3 PF11593.3 EFW98842.1 - 5.3 6.1 6.0 9.2 5.3 4.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Asp_protease_2 PF13650.1 EFW98843.1 - 0.041 14.3 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease Cyclase PF04199.8 EFW98844.1 - 2.3e-15 56.6 0.0 3.3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Mob1_phocein PF03637.12 EFW98845.1 - 1.5e-25 89.9 0.1 2.3e-25 89.2 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family DUF383 PF04063.9 EFW98846.1 - 1.4e-67 226.9 0.3 4.7e-67 225.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.8 EFW98846.1 - 1.2e-21 75.9 0.9 4e-21 74.3 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF384) Trp_repressor PF01371.14 EFW98846.1 - 0.1 12.5 1.1 0.45 10.4 0.2 2.4 2 0 0 2 2 2 0 Trp repressor protein YTH PF04146.10 EFW98847.1 - 4e-55 185.2 0.0 6.1e-55 184.6 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.17 EFW98847.1 - 2.4e-05 23.8 0.2 0.00015 21.2 0.0 2.3 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98847.1 - 0.0085 16.0 0.0 0.027 14.4 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) TPR_1 PF00515.23 EFW98848.1 - 2.3e-54 178.8 35.3 1.9e-08 33.5 0.0 11.0 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_11 PF13414.1 EFW98848.1 - 2.5e-52 174.4 43.0 6e-13 48.2 1.8 6.6 2 2 5 8 8 8 8 TPR repeat TPR_2 PF07719.12 EFW98848.1 - 1e-46 153.0 26.5 9.5e-07 28.2 0.0 10.7 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.1 EFW98848.1 - 8e-39 128.5 24.8 2.2e-07 30.1 0.0 10.3 9 1 1 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.1 EFW98848.1 - 3.2e-35 120.0 14.5 1e-08 35.5 0.0 6.7 5 1 3 8 8 7 7 Tetratricopeptide repeat TPR_12 PF13424.1 EFW98848.1 - 7.8e-32 109.0 17.0 7.9e-08 32.1 0.1 6.7 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_14 PF13428.1 EFW98848.1 - 6.1e-30 100.9 13.0 7.1e-05 23.1 0.0 9.6 3 2 7 10 10 10 9 Tetratricopeptide repeat TPR_17 PF13431.1 EFW98848.1 - 1.7e-29 99.5 21.5 0.00016 21.6 0.0 10.5 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_19 PF14559.1 EFW98848.1 - 2.1e-25 88.8 18.3 3.5e-06 27.2 0.2 6.8 6 1 0 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.1 EFW98848.1 - 3.7e-24 83.4 19.0 8.9e-05 22.7 0.0 10.3 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.1 EFW98848.1 - 8.9e-24 81.3 10.9 0.00064 19.3 0.0 9.4 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.1 EFW98848.1 - 3.7e-15 55.5 11.1 0.0022 17.7 0.1 7.0 2 2 6 8 8 8 5 Tetratricopeptide repeat Apc3 PF12895.2 EFW98848.1 - 4.5e-15 55.5 10.2 9.8e-09 35.2 1.4 4.2 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 EFW98848.1 - 1e-12 47.7 7.4 0.00042 19.4 0.8 4.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_21 PF09976.4 EFW98848.1 - 1.9e-07 31.1 6.4 0.0029 17.5 0.0 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 EFW98848.1 - 0.00034 20.6 4.5 0.21 11.6 0.0 4.4 5 1 1 6 6 3 1 Tetratricopeptide repeat DUF2225 PF09986.4 EFW98848.1 - 0.0011 18.4 1.5 1.4 8.3 0.0 2.6 1 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_10 PF13374.1 EFW98848.1 - 0.036 13.9 16.4 6.1 6.9 0.0 6.9 8 0 0 8 8 7 0 Tetratricopeptide repeat MIT PF04212.13 EFW98848.1 - 0.047 13.5 11.9 1.4 8.8 1.0 5.0 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain ChAPs PF09295.5 EFW98848.1 - 0.1 11.3 1.2 27 3.3 0.1 3.2 2 1 2 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.1 EFW98848.1 - 0.66 9.0 15.2 11 5.0 0.1 4.8 3 1 1 5 5 5 0 Soluble NSF attachment protein, SNAP Foie-gras_1 PF11817.3 EFW98848.1 - 0.87 9.0 7.4 2.2 7.7 0.8 3.4 1 1 3 4 4 4 0 Foie gras liver health family 1 RabGAP-TBC PF00566.13 EFW98849.1 - 1.4e-29 103.1 0.0 2.5e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain YchF-GTPase_C PF06071.8 EFW98850.1 - 3e-33 113.4 0.6 6.5e-33 112.3 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 EFW98850.1 - 3.4e-13 49.5 0.0 8.6e-13 48.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFW98850.1 - 0.00025 20.3 0.0 0.0005 19.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.16 EFW98850.1 - 0.0079 16.0 0.0 0.023 14.5 0.0 1.8 1 1 0 1 1 1 1 TGS domain Dynamin_N PF00350.18 EFW98850.1 - 0.019 14.7 0.6 7.1 6.4 0.0 3.2 1 1 1 3 3 3 0 Dynamin family AAA_14 PF13173.1 EFW98850.1 - 0.022 14.6 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFW98850.1 - 0.027 14.1 0.6 3.9 7.1 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B BetaGal_dom3 PF13363.1 EFW98850.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 GN3L_Grn1 PF08701.6 EFW98850.1 - 0.57 10.1 0.1 0.57 10.1 0.0 2.7 3 0 0 3 3 3 0 GNL3L/Grn1 putative GTPase Corona_nucleoca PF00937.13 EFW98851.1 - 0.087 11.7 5.1 0.11 11.4 3.5 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein HATPase_c_3 PF13589.1 EFW98852.1 - 1.6e-13 50.4 0.0 4.1e-13 49.1 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EFW98852.1 - 1.1e-07 31.5 0.0 2.1e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.14 EFW98852.1 - 0.00063 19.1 0.0 0.0015 17.9 0.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Helicase_C_3 PF13625.1 EFW98853.1 - 6.9e-25 87.2 0.0 1.1e-23 83.3 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW98853.1 - 9.9e-15 54.8 0.0 2.1e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFW98853.1 - 2e-11 43.2 0.2 4.1e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFW98853.1 - 3.7e-11 42.7 0.0 8.5e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1338 PF07063.8 EFW98853.1 - 0.039 13.0 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1338) DAO PF01266.19 EFW98854.1 - 1.2e-45 155.9 10.3 1.5e-45 155.6 7.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW98854.1 - 0.00041 20.3 2.4 0.00048 20.0 0.4 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFW98854.1 - 0.0022 18.0 0.4 0.0097 15.9 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFW98854.1 - 0.016 14.9 0.1 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFW98854.1 - 0.12 12.8 0.2 0.23 11.9 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HCV_NS4b PF01001.14 EFW98855.1 - 0.37 10.1 3.9 9.7 5.5 0.0 2.6 2 1 1 3 3 3 0 Hepatitis C virus non-structural protein NS4b NuiA PF07924.6 EFW98856.1 - 0.005 16.7 0.2 0.033 14.0 0.1 2.1 1 1 0 1 1 1 1 Nuclease A inhibitor-like protein Transp_cyt_pur PF02133.10 EFW98857.1 - 1.5e-17 63.2 37.1 2.8e-17 62.3 25.0 1.8 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sld5 PF05916.6 EFW98858.1 - 2.3e-12 47.1 0.0 5.3e-12 45.9 0.0 1.6 1 1 0 1 1 1 1 GINS complex protein Apc15p PF05841.6 EFW98859.1 - 3.5e-16 60.0 0.6 3.5e-16 60.0 0.4 2.6 3 0 0 3 3 3 1 Apc15p protein XPG_N PF00752.12 EFW98861.1 - 3.6e-33 113.8 0.0 1.2e-32 112.2 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 EFW98861.1 - 2.4e-25 88.4 0.0 5.6e-25 87.2 0.0 1.7 1 0 0 1 1 1 1 XPG I-region Rep_4 PF05797.6 EFW98861.1 - 3.9 6.1 8.6 0.21 10.2 0.2 2.4 2 0 0 2 2 2 0 Yeast trans-acting factor (REP1/REP2) Mid2 PF04478.7 EFW98862.1 - 2e-08 33.7 1.8 2.4e-08 33.5 0.1 2.1 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor MecA PF05389.7 EFW98862.1 - 0.13 11.7 0.3 0.21 11.1 0.2 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Yip1 PF04893.12 EFW98863.1 - 1.1e-13 51.0 12.0 2e-13 50.1 8.3 1.4 1 0 0 1 1 1 1 Yip1 domain Serglycin PF04360.7 EFW98863.1 - 0.0068 16.1 6.9 0.014 15.1 4.8 1.6 1 0 0 1 1 1 1 Serglycin YIF1 PF03878.10 EFW98863.1 - 0.67 9.0 4.0 0.96 8.5 2.8 1.1 1 0 0 1 1 1 0 YIF1 DUF1282 PF06930.7 EFW98863.1 - 0.85 9.2 9.8 1.8 8.1 6.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) 7TM_transglut PF14402.1 EFW98863.1 - 1 8.2 8.5 1.4 7.7 5.9 1.1 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase FAD_binding_3 PF01494.14 EFW98864.1 - 1.1e-73 248.3 0.0 1.4e-73 247.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 EFW98864.1 - 4.1e-40 137.1 0.0 6.4e-40 136.5 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox PF00070.22 EFW98864.1 - 3e-05 24.3 0.0 0.0004 20.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFW98864.1 - 0.0016 17.4 0.0 0.047 12.6 0.0 2.4 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW98864.1 - 0.0035 17.3 0.1 0.038 14.0 0.0 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain XdhC_C PF13478.1 EFW98864.1 - 0.006 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 XdhC Rossmann domain Lycopene_cycl PF05834.7 EFW98864.1 - 0.0078 15.1 0.0 0.023 13.6 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.12 EFW98864.1 - 0.0088 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Thi4 family GDI PF00996.13 EFW98864.1 - 0.012 13.9 0.0 0.018 13.3 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Pyr_redox_2 PF07992.9 EFW98864.1 - 0.014 15.3 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFW98864.1 - 0.03 12.7 0.0 0.058 11.8 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.13 EFW98864.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.16 EFW98864.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 ThiF family Lung_7-TM_R PF06814.8 EFW98865.1 - 3.9e-66 223.0 16.7 5e-66 222.6 11.5 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor EMP24_GP25L PF01105.19 EFW98865.1 - 0.096 12.3 0.1 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF1980 PF09323.5 EFW98865.1 - 0.2 11.3 4.6 0.049 13.3 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) GWT1 PF06423.7 EFW98865.1 - 0.23 11.5 6.5 4.6 7.3 0.7 2.8 3 0 0 3 3 3 0 GWT1 DUF4131 PF13567.1 EFW98865.1 - 5.9 6.2 15.0 0.04 13.3 1.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Ras PF00071.17 EFW98866.1 - 2.3e-48 163.6 0.0 1.4e-37 128.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 EFW98866.1 - 2.7e-15 56.8 0.0 3.7e-14 53.2 0.0 2.1 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFW98866.1 - 1.9e-08 33.7 0.0 7.4e-08 31.8 0.0 1.9 2 1 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFW98866.1 - 0.00019 21.3 0.0 0.00039 20.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFW98866.1 - 0.00022 20.7 0.0 0.00063 19.2 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFW98866.1 - 0.00058 19.0 0.0 0.0033 16.6 0.0 1.9 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 EFW98866.1 - 0.027 14.6 0.1 0.15 12.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFW98866.1 - 0.075 13.0 0.2 0.37 10.7 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.2 EFW98866.1 - 0.12 11.8 0.0 0.36 10.2 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain ACBP PF00887.14 EFW98867.1 - 2.5e-29 100.7 0.0 4.1e-29 100.0 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein VSG_B PF13206.1 EFW98867.1 - 0.043 12.9 0.7 0.05 12.7 0.0 1.4 2 0 0 2 2 2 0 Trypanosomal VSG domain DUF2062 PF09835.4 EFW98868.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) DUF2752 PF10825.3 EFW98868.1 - 2.4 8.2 4.7 0.55 10.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) Inhibitor_I9 PF05922.11 EFW98870.1 - 0.025 15.1 0.0 0.03 14.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase inhibitor I9 DUF3186 PF11382.3 EFW98870.1 - 0.089 11.9 0.1 0.089 11.9 0.1 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF3186) DUF4141 PF13605.1 EFW98870.1 - 0.31 10.2 3.2 0.41 9.8 1.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4141) AMP-binding PF00501.23 EFW98872.1 - 1.1e-90 304.0 0.1 1.4e-90 303.7 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFW98872.1 - 1.1e-22 80.8 0.7 1.3e-20 74.0 0.3 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ras PF00071.17 EFW98873.1 - 2.1e-58 196.2 0.2 2.4e-58 196.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFW98873.1 - 3.8e-19 69.3 0.1 6.2e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFW98873.1 - 2e-15 56.4 0.0 2.4e-15 56.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFW98873.1 - 3.1e-08 33.2 0.0 4.3e-08 32.8 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFW98873.1 - 3.5e-08 32.8 0.0 4.4e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFW98873.1 - 7.4e-06 25.9 0.1 1.7e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFW98873.1 - 0.016 14.3 0.3 0.064 12.4 0.0 2.0 2 1 0 3 3 3 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFW98873.1 - 0.035 14.2 0.1 2.4 8.3 0.0 2.4 1 1 1 2 2 2 0 AAA domain Amidase02_C PF12123.3 EFW98873.1 - 0.093 12.3 0.0 0.63 9.7 0.0 2.1 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase G-alpha PF00503.15 EFW98873.1 - 0.13 10.8 0.3 9.7 4.7 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit Metallophos_2 PF12850.2 EFW98876.1 - 4.1e-14 52.6 0.0 5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EFW98876.1 - 0.088 12.1 0.0 0.88 8.9 0.0 2.1 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase AAA_33 PF13671.1 EFW98877.1 - 0.00017 21.4 0.1 0.00027 20.8 0.1 1.3 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.15 EFW98877.1 - 0.0032 17.1 0.1 1.6 8.3 0.0 2.3 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_18 PF13238.1 EFW98877.1 - 0.051 13.8 0.0 0.12 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.13 EFW98878.1 - 3.1e-77 258.6 0.0 4.1e-77 258.2 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EFW98878.1 - 8.1e-29 100.7 0.0 1.5e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EFW98878.1 - 2.8e-08 33.7 0.1 4.8e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 EFW98878.1 - 2.4e-05 23.6 0.0 3.4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 EFW98878.1 - 0.00025 21.8 0.3 0.013 16.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain Pescadillo_N PF06732.6 EFW98879.1 - 1.3e-111 372.4 1.1 2.6e-111 371.4 0.0 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT PF00533.21 EFW98879.1 - 9.2e-09 35.3 0.0 3.1e-08 33.6 0.0 2.0 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RRM_6 PF14259.1 EFW98880.1 - 0.003 17.5 0.1 3.2 7.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF1168 PF06658.7 EFW98881.1 - 1.1e-33 115.6 13.6 1.1e-33 115.6 9.5 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) DUF4407 PF14362.1 EFW98881.1 - 1.5 7.7 10.2 1.8 7.4 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Alpha_GJ PF03229.8 EFW98881.1 - 1.6 9.0 10.8 0.46 10.8 4.8 2.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J DUF2413 PF10310.4 EFW98881.1 - 1.7 7.3 10.5 2.2 7.0 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Menin PF05053.8 EFW98881.1 - 5.7 4.9 9.1 7.4 4.5 6.3 1.1 1 0 0 1 1 1 0 Menin 7TMR-HDED PF07697.6 EFW98883.1 - 0.088 12.5 6.1 0.15 11.7 4.3 1.3 1 0 0 1 1 1 0 7TM-HD extracellular Prothymosin PF03247.9 EFW98883.1 - 0.31 11.2 6.0 0.92 9.6 4.2 1.8 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF2501 PF10696.4 EFW98883.1 - 0.6 10.1 2.2 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2501) APG6 PF04111.7 EFW98883.1 - 2.5 7.0 5.2 4 6.4 3.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1682 PF07946.9 EFW98883.1 - 3 6.5 8.3 4.9 5.9 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MFS_1 PF07690.11 EFW98884.1 - 2e-29 102.3 27.0 2.7e-29 101.9 18.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.14 EFW98885.1 - 2e-38 131.2 0.0 9.3e-38 129.1 0.0 1.8 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFW98885.1 - 9.6e-05 21.8 0.0 0.00013 21.4 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Bac_rhodopsin PF01036.13 EFW98887.1 - 1.9e-27 96.0 24.3 2.5e-27 95.6 16.8 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF1349 PF07081.6 EFW98888.1 - 1.2e-15 57.3 0.0 2.7e-15 56.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) Pkinase PF00069.20 EFW98889.1 - 1.3e-52 178.5 0.0 2.9e-52 177.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW98889.1 - 1.5e-23 83.2 0.0 3.5e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFW98889.1 - 0.00061 19.5 0.1 0.00061 19.5 0.1 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFW98889.1 - 0.011 15.0 2.7 0.012 14.9 0.2 2.1 2 1 0 2 2 2 0 RIO1 family Choline_kinase PF01633.15 EFW98889.1 - 0.28 10.7 1.2 0.58 9.6 0.2 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF3614 PF12267.3 EFW98889.1 - 0.5 10.6 3.2 1.7 8.9 2.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) Thi4 PF01946.12 EFW98890.1 - 3.6e-103 343.6 0.2 4.4e-103 343.3 0.2 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 EFW98890.1 - 1.6e-08 33.9 0.7 1.1e-07 31.0 0.5 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW98890.1 - 1.3e-05 25.1 1.1 4e-05 23.5 0.8 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFW98890.1 - 0.0001 21.3 3.3 0.00052 18.9 0.5 2.4 2 1 1 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.7 EFW98890.1 - 0.00011 21.2 1.1 0.00044 19.2 0.3 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 EFW98890.1 - 0.00049 20.0 0.1 0.0007 19.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFW98890.1 - 0.00055 20.0 0.3 0.00099 19.2 0.2 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFW98890.1 - 0.00058 19.6 1.7 0.001 18.8 0.0 2.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_oxidored PF12831.2 EFW98890.1 - 0.0064 15.6 0.3 0.012 14.6 0.2 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 EFW98890.1 - 0.027 13.3 0.1 0.096 11.5 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.9 EFW98890.1 - 0.055 11.9 0.6 0.085 11.3 0.4 1.2 1 0 0 1 1 1 0 HI0933-like protein Hpt PF01627.18 EFW98891.1 - 5.2e-12 45.6 0.0 8.9e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Hpt domain MOZART1 PF12554.3 EFW98892.1 - 2.7e-23 81.1 0.9 3.1e-23 80.9 0.6 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated G-alpha PF00503.15 EFW98893.1 - 5.4e-134 446.7 2.2 6.6e-134 446.4 1.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EFW98893.1 - 1.4e-15 56.9 1.0 2.2e-10 40.0 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.15 EFW98893.1 - 0.00089 18.7 0.0 0.0038 16.7 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger Miro PF08477.8 EFW98893.1 - 0.0012 19.2 0.1 2.2 8.8 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 EFW98893.1 - 0.0074 15.4 2.2 0.54 9.3 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 EFW98893.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 EFW98893.1 - 0.028 13.8 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MCM PF00493.18 EFW98893.1 - 0.063 12.0 0.0 0.1 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM2/3/5 family FtsK_SpoIIIE PF01580.13 EFW98893.1 - 0.083 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 EFW98893.1 - 0.13 12.2 0.0 15 5.6 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Septin PF00735.13 EFW98894.1 - 4e-13 49.0 0.0 1e-09 37.8 0.0 2.4 3 0 0 3 3 3 2 Septin Sigma54_activat PF00158.21 EFW98894.1 - 0.0018 17.7 0.0 0.98 8.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain MMR_HSR1 PF01926.18 EFW98894.1 - 0.0024 17.7 0.0 0.011 15.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFW98894.1 - 0.0033 17.9 0.1 0.0088 16.5 0.1 1.7 1 0 0 1 1 1 1 Miro-like protein FtsK_SpoIIIE PF01580.13 EFW98894.1 - 0.0041 16.6 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_29 PF13555.1 EFW98894.1 - 0.017 14.6 0.2 0.76 9.3 0.2 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain DUF258 PF03193.11 EFW98894.1 - 0.028 13.6 0.0 0.099 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 EFW98894.1 - 0.03 14.6 0.0 0.054 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 EFW98894.1 - 0.05 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EFW98894.1 - 0.053 12.6 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin T2SE PF00437.15 EFW98894.1 - 0.063 12.1 0.0 0.13 11.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF815 PF05673.8 EFW98894.1 - 0.067 12.0 0.1 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.1 EFW98894.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFW98894.1 - 0.088 13.1 0.1 0.26 11.5 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_22 PF13401.1 EFW98894.1 - 0.093 12.8 0.0 0.64 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 EFW98894.1 - 0.099 12.2 0.3 0.4 10.3 0.1 2.1 2 0 0 2 2 2 0 NACHT domain UPF0079 PF02367.12 EFW98894.1 - 0.14 11.7 0.1 0.52 9.9 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Lon_C PF05362.8 EFW98895.1 - 1.1e-64 217.5 0.0 2.2e-64 216.5 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.24 EFW98895.1 - 1.4e-22 80.2 0.1 4.5e-22 78.6 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) LON PF02190.11 EFW98895.1 - 2.4e-20 73.0 0.0 8.2e-20 71.3 0.0 1.9 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain ChlI PF13541.1 EFW98895.1 - 1.4e-07 31.0 0.0 3.4e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 EFW98895.1 - 1.7e-07 31.0 0.7 7.1e-07 29.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFW98895.1 - 1.8e-07 31.3 1.4 6.7e-07 29.4 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 EFW98895.1 - 2e-05 24.0 0.0 3.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.6 EFW98895.1 - 5.8e-05 22.7 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFW98895.1 - 6.5e-05 23.7 0.0 0.0002 22.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFW98895.1 - 9.7e-05 21.5 0.1 0.00031 19.8 0.1 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFW98895.1 - 0.00038 20.6 0.0 0.0032 17.6 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFW98895.1 - 0.00088 19.1 0.0 0.0024 17.7 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EFW98895.1 - 0.00098 19.0 1.4 0.0032 17.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFW98895.1 - 0.002 17.5 0.0 0.0047 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFW98895.1 - 0.0046 16.6 0.2 0.026 14.2 0.0 2.4 2 0 0 2 2 1 1 Part of AAA domain AAA_2 PF07724.9 EFW98895.1 - 0.0048 16.8 1.3 0.03 14.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.8 EFW98895.1 - 0.0094 14.7 0.0 0.021 13.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus NB-ARC PF00931.17 EFW98895.1 - 0.014 14.2 0.3 0.03 13.1 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain DUF258 PF03193.11 EFW98895.1 - 0.015 14.5 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Rad17 PF03215.10 EFW98895.1 - 0.028 13.1 0.0 0.044 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein MobB PF03205.9 EFW98895.1 - 0.029 14.0 0.0 0.072 12.7 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 EFW98895.1 - 0.032 13.3 2.3 0.064 12.3 0.0 2.2 1 1 1 2 2 2 0 Zeta toxin AAA_18 PF13238.1 EFW98895.1 - 0.032 14.5 0.0 0.079 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFW98895.1 - 0.04 13.5 0.1 0.22 11.1 0.0 2.3 1 1 2 3 3 3 0 Archaeal ATPase RNA_helicase PF00910.17 EFW98895.1 - 0.048 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 EFW98895.1 - 0.052 13.2 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain UPF0079 PF02367.12 EFW98895.1 - 0.054 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_24 PF13479.1 EFW98895.1 - 0.054 13.0 0.1 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 EFW98895.1 - 0.26 9.9 0.1 0.4 9.2 0.1 1.2 1 0 0 1 1 1 0 G-protein alpha subunit APG6 PF04111.7 EFW98895.1 - 0.35 9.8 9.0 0.53 9.2 6.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.1 EFW98895.1 - 0.81 9.9 6.8 2.3 8.4 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_11 PF13086.1 EFW98895.1 - 1.9 7.9 6.8 3.4 7.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.6 EFW98895.1 - 2.3 6.7 8.7 4.9 5.7 6.1 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein ABC_tran PF00005.22 EFW98895.1 - 2.5 8.4 5.9 2.5 8.3 0.0 2.6 1 1 1 2 2 2 0 ABC transporter MFS_1 PF07690.11 EFW98896.1 - 3.5e-15 55.5 51.6 4.7e-14 51.8 35.3 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Fringe PF02434.11 EFW98897.1 - 9.7e-06 24.9 0.0 7.7e-05 22.0 0.0 2.0 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.16 EFW98897.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase Methyltransf_25 PF13649.1 EFW98898.1 - 1.4e-10 41.3 0.0 2.5e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW98898.1 - 1.8e-10 41.3 0.0 2.9e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFW98898.1 - 2.2e-10 40.8 0.0 3.4e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFW98898.1 - 5.5e-09 35.9 0.0 8.9e-09 35.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW98898.1 - 1.9e-07 30.8 0.0 2.5e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW98898.1 - 3.2e-07 30.7 0.0 5.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW98898.1 - 3.7e-06 26.9 0.0 8.4e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EFW98898.1 - 0.01 14.5 0.0 0.013 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_4 PF02390.12 EFW98898.1 - 0.025 13.6 0.0 0.54 9.2 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.9 EFW98898.1 - 0.04 13.2 0.0 0.19 11.0 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 EFW98898.1 - 0.042 12.9 0.0 0.054 12.5 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Glyco_hydro_cc PF11790.3 EFW98899.1 - 1.3e-59 201.5 2.7 2.1e-59 200.8 1.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core BCNT PF07572.7 EFW98901.1 - 5.1e-22 77.6 0.3 1e-21 76.6 0.2 1.5 1 0 0 1 1 1 1 Bucentaur or craniofacial development IER PF05760.7 EFW98901.1 - 0.46 10.3 5.5 0.83 9.5 3.8 1.4 1 0 0 1 1 1 0 Immediate early response protein (IER) DNA_mis_repair PF01119.14 EFW98903.1 - 5e-30 103.3 0.0 7.8e-30 102.7 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 EFW98903.1 - 3e-11 43.1 0.0 5.1e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EFW98903.1 - 2.7e-10 39.9 0.0 5.9e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Thioredoxin_8 PF13905.1 EFW98903.1 - 0.081 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like OPT PF03169.10 EFW98904.1 - 1.2e-144 483.1 30.5 1.4e-144 482.8 21.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein RNase_PH PF01138.16 EFW98905.1 - 1.6e-16 60.7 0.2 1e-15 58.2 0.1 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 TPR_19 PF14559.1 EFW98905.1 - 0.23 11.8 2.5 0.37 11.1 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFW98905.1 - 0.62 10.6 6.4 0.24 11.9 2.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_1 PF00076.17 EFW98906.1 - 5.3e-11 41.9 0.1 9.7e-08 31.5 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98906.1 - 2.1e-09 37.1 0.1 1.4e-05 25.0 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW98906.1 - 6.9e-08 32.2 0.0 0.00034 20.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Daxx PF03344.10 EFW98906.1 - 0.018 13.5 5.0 0.024 13.1 3.4 1.2 1 0 0 1 1 1 0 Daxx Family Mito_carr PF00153.22 EFW98907.1 - 5.4e-44 147.8 8.6 5.3e-17 61.3 0.3 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Complex1_LYR PF05347.10 EFW98907.1 - 3.1e-06 26.8 1.6 8.6e-06 25.4 1.1 1.8 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFW98907.1 - 0.26 11.5 3.7 0.16 12.2 0.8 2.0 2 0 0 2 2 2 0 Complex1_LYR-like Ank PF00023.25 EFW98908.1 - 7.4e-17 60.2 0.0 8.8e-11 41.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Methyltransf_23 PF13489.1 EFW98908.1 - 1.1e-15 57.6 0.0 2.7e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ank_4 PF13637.1 EFW98908.1 - 1.4e-15 57.2 0.1 5.1e-09 36.4 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFW98908.1 - 9.3e-14 51.5 0.0 2.7e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFW98908.1 - 3e-12 46.3 0.1 5.4e-09 36.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW98908.1 - 1.6e-09 37.0 0.0 1.4e-06 27.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Methyltransf_11 PF08241.7 EFW98908.1 - 2.3e-08 34.3 0.1 1.8e-07 31.5 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW98908.1 - 1.4e-07 32.0 0.0 8.6e-07 29.5 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW98908.1 - 7.2e-07 28.9 0.3 3.6e-06 26.6 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW98908.1 - 5.1e-06 26.8 0.0 8.4e-05 22.9 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW98908.1 - 0.00027 21.2 0.0 0.00091 19.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFW98908.1 - 0.00038 19.5 0.0 0.00093 18.3 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFW98908.1 - 0.0012 18.8 0.0 0.0052 16.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFW98908.1 - 0.0016 18.4 0.1 0.02 14.8 0.0 2.3 2 0 0 2 2 2 1 FtsJ-like methyltransferase MTS PF05175.9 EFW98908.1 - 0.0019 17.6 0.0 0.006 15.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EFW98908.1 - 0.0051 15.9 4.7 0.0055 15.8 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.13 EFW98908.1 - 0.044 12.8 0.0 0.099 11.7 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family AAA_13 PF13166.1 EFW98908.1 - 0.082 11.3 8.2 0.14 10.5 5.7 1.3 1 0 0 1 1 1 0 AAA domain FAD-oxidase_C PF02913.14 EFW98909.1 - 1.8e-58 197.7 0.0 2.6e-58 197.2 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EFW98909.1 - 6.3e-37 126.1 0.2 1.1e-36 125.3 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Na_Ca_ex PF01699.19 EFW98911.1 - 1.1e-05 25.0 21.8 0.017 14.7 4.7 3.3 2 2 0 2 2 2 2 Sodium/calcium exchanger protein COX2_TM PF02790.10 EFW98911.1 - 0.057 13.3 1.4 0.82 9.6 0.0 3.1 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain Proteasome PF00227.21 EFW98912.1 - 2.5e-28 98.6 0.2 5e-28 97.6 0.1 1.4 1 1 0 1 1 1 1 Proteasome subunit PI3_PI4_kinase PF00454.22 EFW98913.1 - 1.8e-39 135.6 0.0 9.5e-39 133.2 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 EFW98913.1 - 1.6e-22 79.5 0.0 4.3e-22 78.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Erythro_esteras PF05139.9 EFW98913.1 - 0.035 13.2 0.0 0.083 12.0 0.0 1.6 1 0 0 1 1 1 0 Erythromycin esterase DUF829 PF05705.9 EFW98914.1 - 1.1e-39 136.6 0.0 1.4e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Desmo_N PF06771.6 EFW98914.1 - 0.039 13.8 0.0 9.8 6.1 0.0 2.3 2 0 0 2 2 2 0 Viral Desmoplakin N-terminus Nif11 PF07862.6 EFW98914.1 - 0.14 12.0 0.1 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function HTH_12 PF08461.5 EFW98915.1 - 0.013 15.1 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain DUF3300 PF11737.3 EFW98915.1 - 0.035 13.3 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3300) IER PF05760.7 EFW98915.1 - 0.051 13.4 0.4 0.076 12.9 0.3 1.2 1 0 0 1 1 1 0 Immediate early response protein (IER) GCFC PF07842.7 EFW98916.1 - 9.8e-61 205.5 7.4 9.8e-61 205.5 5.2 1.9 1 1 1 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.18 EFW98916.1 - 1e-15 57.2 1.2 2.8e-15 55.8 0.9 1.8 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.3 EFW98916.1 - 2.5e-12 46.8 9.3 2.5e-12 46.8 6.5 2.8 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.2 EFW98916.1 - 1.2e-07 31.4 0.8 4e-07 29.7 0.6 2.0 1 0 0 1 1 1 1 DExH-box splicing factor binding site CLASP_N PF12348.3 EFW98916.1 - 0.00035 20.0 0.0 0.0041 16.5 0.0 2.2 2 0 0 2 2 2 1 CLASP N terminal Adaptin_N PF01602.15 EFW98916.1 - 0.0063 14.9 0.1 2.5 6.3 0.0 2.2 2 0 0 2 2 2 2 Adaptin N terminal region HEAT PF02985.17 EFW98916.1 - 0.009 16.0 0.3 1.1 9.4 0.0 3.9 4 0 0 4 4 4 1 HEAT repeat DUF4209 PF13910.1 EFW98916.1 - 0.19 11.8 0.0 0.57 10.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4209) Cep57_CLD_2 PF14197.1 EFW98916.1 - 0.19 11.6 18.7 2 8.3 5.4 3.1 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 APG6 PF04111.7 EFW98916.1 - 2.1 7.3 15.0 0.086 11.8 4.6 2.4 2 0 0 2 2 2 0 Autophagy protein Apg6 LysM PF01476.15 EFW98917.1 - 1.6e-09 37.4 0.0 5.8e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 LysM domain DEAD PF00270.24 EFW98918.1 - 6.3e-23 81.0 0.0 1.2e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.5 EFW98918.1 - 5.2e-10 39.7 1.9 7.6e-10 39.2 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) Ran_BP1 PF00638.13 EFW98918.1 - 2.6e-09 37.1 0.2 0.00022 21.2 0.0 2.3 2 0 0 2 2 2 2 RanBP1 domain Helicase_C PF00271.26 EFW98918.1 - 1.8e-07 30.9 0.0 7.8e-07 28.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain EBV-NA3 PF05009.7 EFW98918.1 - 7.7 5.6 6.9 22 4.1 4.1 2.0 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Fungal_trans PF04082.13 EFW98919.1 - 3.8e-26 91.5 0.0 5.8e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Herpes_UL6 PF01763.11 EFW98920.1 - 0.05 11.7 1.9 0.15 10.1 1.1 1.7 1 1 1 2 2 2 0 Herpesvirus UL6 like Fzo_mitofusin PF04799.8 EFW98920.1 - 0.081 12.3 1.1 0.14 11.5 0.7 1.3 1 0 0 1 1 1 0 fzo-like conserved region AAA_11 PF13086.1 EFW98920.1 - 0.15 11.6 0.9 0.17 11.4 0.7 1.1 1 0 0 1 1 1 0 AAA domain DASH_Dam1 PF08653.5 EFW98920.1 - 0.16 11.7 1.2 2 8.2 0.1 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 HSCB_C PF07743.8 EFW98920.1 - 0.25 11.8 3.4 0.65 10.4 0.4 2.3 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain Transposase_24 PF03004.9 EFW98920.1 - 0.67 9.8 5.2 6 6.7 0.1 2.5 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) PIF1 PF05970.9 EFW98921.1 - 4.1e-34 118.1 0.0 1.3e-22 80.2 0.0 3.3 3 0 0 3 3 3 3 PIF1-like helicase AAA_30 PF13604.1 EFW98921.1 - 4.9e-16 58.9 0.0 1e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.9 EFW98921.1 - 1.5e-08 32.9 0.2 4.3e-07 28.1 0.0 2.5 3 0 0 3 3 3 1 Helicase AAA_22 PF13401.1 EFW98921.1 - 4.7e-07 30.0 0.0 9.4e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFW98921.1 - 9.4e-07 28.5 1.1 2.5e-06 27.1 0.5 2.0 1 1 1 2 2 1 1 Part of AAA domain UvrD_C_2 PF13538.1 EFW98921.1 - 2.1e-06 27.8 0.0 5.8e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 EFW98921.1 - 0.00013 21.5 0.3 0.58 9.6 0.0 2.8 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 EFW98921.1 - 0.00065 19.4 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 EFW98921.1 - 0.0043 16.5 0.0 0.0091 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain APS_kinase PF01583.15 EFW98921.1 - 0.0059 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase IstB_IS21 PF01695.12 EFW98921.1 - 0.0074 15.7 0.1 0.89 8.9 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein PhoH PF02562.11 EFW98921.1 - 0.0084 15.3 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_33 PF13671.1 EFW98921.1 - 0.012 15.4 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 EFW98921.1 - 0.019 14.6 0.0 4 7.1 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_17 PF13207.1 EFW98921.1 - 0.019 15.7 2.4 0.02 15.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EFW98921.1 - 0.021 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 EFW98921.1 - 0.021 15.1 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.1 EFW98921.1 - 0.023 14.2 0.1 2.1 7.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EFW98921.1 - 0.027 14.7 0.2 0.098 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 EFW98921.1 - 0.027 14.6 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.24 EFW98921.1 - 0.03 13.8 0.1 0.45 9.9 0.0 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_14 PF13173.1 EFW98921.1 - 0.054 13.3 0.0 0.17 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFW98921.1 - 0.066 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Helicase_RecD PF05127.9 EFW98921.1 - 0.069 12.7 0.5 0.33 10.5 0.0 2.3 2 1 0 2 2 2 0 Helicase Rad17 PF03215.10 EFW98921.1 - 0.12 11.0 0.0 0.19 10.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein RNA_helicase PF00910.17 EFW98921.1 - 0.19 11.9 0.0 0.75 9.9 0.0 2.0 1 1 0 1 1 1 0 RNA helicase DUF1900 PF08954.6 EFW98922.1 - 1.6e-49 166.8 0.0 6.6e-48 161.6 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 EFW98922.1 - 9.3e-34 114.8 0.0 1.6e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.27 EFW98922.1 - 2.1e-25 87.6 1.5 1.3e-07 31.2 0.3 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat eIF2A PF08662.6 EFW98922.1 - 0.0018 18.0 0.0 0.0043 16.7 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EFW98922.1 - 0.0027 15.8 2.2 0.51 8.3 0.2 2.5 2 1 1 3 3 3 2 Nucleoporin Nup120/160 alpha-hel2 PF14456.1 EFW98922.1 - 0.089 11.5 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Alpha-helical domain 2 UPF0061 PF02696.9 EFW98923.1 - 4e-115 384.8 0.0 6.6e-115 384.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family HSP70 PF00012.15 EFW98924.1 - 1.8e-266 884.8 16.4 2.1e-266 884.6 11.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFW98924.1 - 4.2e-15 55.1 5.4 5.5e-13 48.2 1.0 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 EFW98924.1 - 8.9e-07 28.7 0.2 0.00073 19.2 0.0 2.5 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 EFW98924.1 - 0.00078 19.2 7.0 0.8 9.5 0.1 4.6 1 1 2 3 3 3 2 Cell division protein FtsA DUF4363 PF14276.1 EFW98924.1 - 0.29 10.8 2.8 0.63 9.7 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Tom22 PF04281.8 EFW98924.1 - 0.46 10.0 8.4 1 8.8 5.8 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Hydantoinase_A PF01968.13 EFW98924.1 - 2.3 7.2 7.9 1.3 8.1 0.0 3.5 3 1 0 4 4 4 0 Hydantoinase/oxoprolinase Maf PF02545.9 EFW98925.1 - 1.9e-37 128.2 0.0 5.4e-37 126.8 0.0 1.7 1 1 0 1 1 1 1 Maf-like protein DUF4557 PF15101.1 EFW98925.1 - 0.0048 16.7 10.0 0.012 15.4 7.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4557) FHIPEP PF00771.15 EFW98925.1 - 0.24 9.6 2.4 0.39 8.9 1.7 1.2 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.11 EFW98925.1 - 0.62 9.8 1.9 1.8 8.3 1.0 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ctr PF04145.10 EFW98925.1 - 1.5 8.8 2.7 5.2 7.1 1.8 2.0 1 0 0 1 1 1 0 Ctr copper transporter family zf-DHHC PF01529.15 EFW98925.1 - 1.6 8.1 2.6 1 8.7 0.1 1.9 2 0 0 2 2 2 0 DHHC palmitoyltransferase AUX_IAA PF02309.11 EFW98925.1 - 2.5 7.7 9.0 0.73 9.5 1.5 2.4 2 0 0 2 2 2 0 AUX/IAA family Serinc PF03348.10 EFW98925.1 - 2.8 6.5 5.4 4.7 5.8 3.7 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3373 PF11853.3 EFW98925.1 - 4.2 5.7 5.2 6 5.2 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) RR_TM4-6 PF06459.7 EFW98925.1 - 4.3 7.1 7.8 14 5.4 5.4 1.8 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1980 PF09323.5 EFW98925.1 - 5.4 6.7 6.1 11 5.7 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) RCC1_2 PF13540.1 EFW98926.1 - 9.7e-14 50.5 9.7 8.4e-06 25.2 0.2 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 EFW98926.1 - 2e-09 37.5 10.6 3e-06 27.3 0.0 5.2 4 2 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Fungal_trans PF04082.13 EFW98927.1 - 4.7e-05 22.3 0.0 0.00019 20.4 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain RRM_5 PF13893.1 EFW98928.1 - 4.6e-06 26.3 0.1 7.9e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFW98928.1 - 1.5e-05 24.5 0.0 2.8e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW98928.1 - 3e-05 23.9 0.0 8.4e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.8 EFW98928.1 - 0.00087 19.4 0.0 0.0032 17.6 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase II-binding domain. PAT1 PF09770.4 EFW98928.1 - 4.3 5.4 19.3 6.1 4.9 13.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RPA_C PF08784.6 EFW98929.1 - 1e-12 48.3 0.7 1.6e-12 47.7 0.1 1.6 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 EFW98929.1 - 4.3e-08 32.8 0.1 2.5e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Tubulin_2 PF13809.1 EFW98929.1 - 0.066 12.1 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 Tubulin like Ribosomal_S6e PF01092.14 EFW98930.1 - 1.7e-59 199.0 0.2 2.9e-59 198.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Cadherin_C PF01049.12 EFW98930.1 - 0.06 13.3 0.5 0.1 12.6 0.4 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic region Sugar_tr PF00083.19 EFW98931.1 - 8e-106 354.3 11.7 1.2e-104 350.4 8.1 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_72 PF03198.9 EFW98931.1 - 2.2e-102 342.3 0.0 3.1e-102 341.7 0.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase MFS_1 PF07690.11 EFW98931.1 - 3.7e-24 85.0 37.2 3.4e-23 81.9 18.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_2_C PF02836.12 EFW98931.1 - 0.0016 17.3 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain RAP1 PF07218.6 EFW98931.1 - 7.3 4.5 3.2 11 3.9 2.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SAPS PF04499.10 EFW98932.1 - 7.8e-190 631.5 0.0 2.2e-188 626.7 0.0 2.1 1 1 0 1 1 1 1 SIT4 phosphatase-associated protein DUF3123 PF11321.3 EFW98932.1 - 0.052 13.8 1.6 7.1 6.9 1.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Pil1 PF13805.1 EFW98933.1 - 6.4e-156 517.4 0.4 7.9e-156 517.1 0.3 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.6 EFW98933.1 - 1.3 8.3 8.8 0.3 10.4 2.9 2.2 2 1 0 2 2 2 0 FAM92 protein Rotamase PF00639.16 EFW98934.1 - 6.5e-18 65.2 0.0 1.2e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 EFW98934.1 - 6.7e-17 61.8 0.7 1.3e-16 60.9 0.0 1.7 1 1 1 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 EFW98934.1 - 2.7e-06 28.0 0.9 4.1e-06 27.4 0.1 1.7 1 1 1 2 2 2 1 PPIC-type PPIASE domain HC2 PF07382.6 EFW98934.1 - 0.4 10.5 4.4 0.47 10.2 3.1 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Ctf8 PF09696.5 EFW98936.1 - 4.3e-30 104.0 0.0 5.2e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 Ctf8 HOOK PF05622.7 EFW98937.1 - 5.4e-08 31.1 29.8 5.4e-08 31.1 20.6 4.2 2 2 1 3 3 3 1 HOOK protein LMBR1 PF04791.11 EFW98937.1 - 0.00077 18.1 0.0 5 5.5 0.0 3.1 2 2 0 2 2 2 1 LMBR1-like membrane protein CH PF00307.26 EFW98937.1 - 0.00088 19.2 0.1 0.0023 17.9 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain Pol_alpha_B_N PF08418.5 EFW98938.1 - 7.4e-05 22.4 3.2 9.7e-05 22.0 2.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal PGA2 PF07543.7 EFW98938.1 - 0.039 13.7 9.0 0.07 12.9 6.2 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 Pex16 PF08610.5 EFW98938.1 - 1 8.2 4.6 1.5 7.7 3.2 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) ORC6 PF05460.8 EFW98938.1 - 5.6 5.9 15.1 6.8 5.6 8.7 1.8 1 1 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Syja_N PF02383.13 EFW98939.1 - 3.5e-82 275.7 0.0 4.7e-82 275.3 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Acetyltransf_7 PF13508.1 EFW98940.1 - 1.7e-07 31.3 0.1 3.3e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFW98940.1 - 5.1e-06 26.4 0.0 1.2e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 EFW98940.1 - 0.00017 21.4 0.1 0.0003 20.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFW98940.1 - 0.00073 19.6 0.1 0.0016 18.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFW98940.1 - 0.0089 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.5 EFW98940.1 - 0.05 13.3 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein Velvet PF11754.3 EFW98941.1 - 2.5e-67 226.4 0.0 3.9e-67 225.7 0.0 1.3 1 0 0 1 1 1 1 Velvet factor Ribosomal_60s PF00428.14 EFW98941.1 - 0.025 14.9 9.0 0.65 10.4 1.0 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Shadoo PF14999.1 EFW98941.1 - 1.6 8.5 16.5 1.8 8.4 4.9 2.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective RGS PF00615.14 EFW98942.1 - 7.8e-34 116.3 0.0 1.7e-33 115.1 0.0 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.16 EFW98942.1 - 1.2e-19 69.8 0.0 3e-14 52.5 0.0 3.1 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DEAD PF00270.24 EFW98944.1 - 1.2e-42 145.3 0.0 3.1e-42 143.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EFW98944.1 - 1.1e-22 79.3 0.6 2.3e-22 78.3 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EFW98944.1 - 9.3e-18 63.8 0.0 2.1e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Neuropeptide_S PF14993.1 EFW98944.1 - 0.047 13.3 0.1 0.32 10.6 0.0 2.2 2 0 0 2 2 2 0 Neuropeptide S precursor protein Spore_coat_CotO PF14153.1 EFW98944.1 - 0.26 10.7 8.8 0.41 10.0 6.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO ResIII PF04851.10 EFW98944.1 - 0.75 9.6 3.8 0.61 9.8 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2457 PF10446.4 EFW98944.1 - 0.75 8.4 16.9 1.2 7.7 11.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CMV_1a PF12467.3 EFW98944.1 - 6.5 7.0 11.6 12 6.2 8.0 1.4 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family FAD_binding_3 PF01494.14 EFW98945.1 - 1.2e-12 47.5 0.6 0.0012 17.9 0.1 3.1 3 0 0 3 3 3 3 FAD binding domain DAO PF01266.19 EFW98945.1 - 1.1e-05 24.5 0.1 0.00061 18.7 0.0 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW98945.1 - 0.0002 21.2 0.3 0.0013 18.6 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFW98945.1 - 0.002 18.2 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EFW98945.1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.22 EFW98945.1 - 0.032 14.6 0.0 0.14 12.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 EFW98945.1 - 0.089 12.2 0.1 0.18 11.2 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.9 EFW98945.1 - 0.099 12.5 0.1 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_28 PF02636.12 EFW98946.1 - 9.5e-74 247.9 0.0 1.2e-73 247.6 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase SSP160 PF06933.6 EFW98946.1 - 7.7 4.3 21.6 13 3.6 15.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 UPF0183 PF03676.9 EFW98950.1 - 2e-32 112.3 0.0 7.5e-22 77.4 0.0 3.4 3 0 0 3 3 3 3 Uncharacterised protein family (UPF0183) Herpes_LMP2 PF07415.6 EFW98950.1 - 2.1 6.8 5.0 4.6 5.7 3.4 1.5 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Tim54 PF11711.3 EFW98950.1 - 7.8 4.9 10.2 1.1 7.7 3.4 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Aminotran_1_2 PF00155.16 EFW98951.1 - 4.1e-63 213.5 0.0 6.7e-63 212.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II RFC1 PF08519.7 EFW98951.1 - 6.1e-57 191.7 0.0 1.4e-56 190.5 0.0 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.24 EFW98951.1 - 1.9e-09 37.8 0.0 6.3e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.21 EFW98951.1 - 1.7e-08 34.4 0.0 4.2e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA_22 PF13401.1 EFW98951.1 - 1.6e-05 25.0 0.0 5.7e-05 23.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFW98951.1 - 8.7e-05 22.2 1.1 0.0004 20.0 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_16 PF13191.1 EFW98951.1 - 0.0003 20.8 0.2 0.0065 16.4 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain Rad17 PF03215.10 EFW98951.1 - 0.00083 18.1 0.0 0.0019 16.9 0.0 1.5 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 EFW98951.1 - 0.00084 20.1 0.0 0.00084 20.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.1 EFW98951.1 - 0.013 15.4 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFW98951.1 - 0.018 15.3 2.4 0.02 15.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EFW98951.1 - 0.026 14.2 0.0 0.091 12.4 0.0 2.0 2 0 0 2 2 2 0 NTPase DNA_pol3_delta PF06144.8 EFW98951.1 - 0.028 13.9 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit RuvB_N PF05496.7 EFW98951.1 - 0.053 12.5 0.0 0.098 11.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus NACHT PF05729.7 EFW98951.1 - 0.06 13.0 0.0 0.86 9.2 0.0 2.5 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 EFW98951.1 - 0.13 12.4 0.0 0.48 10.6 0.0 2.1 2 0 0 2 2 1 0 RNA helicase DSPc PF00782.15 EFW98952.1 - 3e-27 94.8 0.0 1.6e-21 76.2 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFW98952.1 - 3.9e-05 23.1 0.0 0.00034 20.0 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Vps51 PF08700.6 EFW98953.1 - 5.4e-15 54.9 0.0 8.4e-14 51.1 0.0 2.6 2 0 0 2 2 2 1 Vps51/Vps67 SNF2_N PF00176.18 EFW98954.1 - 4.9e-83 278.3 0.8 4.9e-83 278.3 0.5 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.20 EFW98954.1 - 1.9e-19 69.3 0.2 5.3e-19 67.9 0.1 1.8 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.26 EFW98954.1 - 1.9e-19 69.2 0.4 7.2e-17 61.0 0.0 3.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.1 EFW98954.1 - 5.7e-17 61.6 0.1 5.7e-17 61.6 0.1 3.9 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.6 EFW98954.1 - 1.1e-12 47.1 1.0 1.1e-12 47.1 0.7 1.9 2 0 0 2 2 2 1 QLQ HSA PF07529.8 EFW98954.1 - 1.1e-12 47.5 13.1 1.1e-12 47.5 9.1 2.4 2 0 0 2 2 2 1 HSA TSA PF03249.8 EFW98954.1 - 0.43 9.0 11.0 0.96 7.9 7.6 1.5 1 0 0 1 1 1 0 Type specific antigen MT-A70 PF05063.9 EFW98955.1 - 7e-24 84.3 0.0 5.1e-23 81.5 0.0 1.9 1 1 0 1 1 1 1 MT-A70 Methyltransf_26 PF13659.1 EFW98955.1 - 0.44 10.6 5.5 0.063 13.3 0.5 2.1 2 2 0 2 2 2 0 Methyltransferase domain OSCP PF00213.13 EFW98956.1 - 1.8e-40 138.6 1.3 2.1e-40 138.4 0.9 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Shufflon_N PF04917.7 EFW98956.1 - 0.042 12.9 0.1 0.058 12.4 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Shugoshin_N PF07558.6 EFW98957.1 - 1.2e-14 53.6 2.7 2.6e-14 52.6 1.9 1.6 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.6 EFW98957.1 - 7e-12 44.5 6.7 7e-12 44.5 4.7 2.9 3 0 0 3 3 3 1 Shugoshin C terminus Mod_r PF07200.8 EFW98957.1 - 0.021 14.7 0.9 0.055 13.3 0.6 1.7 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein AKNA PF12443.3 EFW98957.1 - 0.04 13.9 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 AT-hook-containing transcription factor TP6A_N PF04406.9 EFW98958.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Type IIB DNA topoisomerase MFS_1 PF07690.11 EFW98959.1 - 3.1e-32 111.6 26.7 3.1e-32 111.6 18.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily ACT_7 PF13840.1 EFW98959.1 - 0.11 12.0 0.5 0.42 10.1 0.3 2.0 1 0 0 1 1 1 0 ACT domain Ribosomal_S8 PF00410.14 EFW98960.1 - 4.1e-25 88.0 0.1 5.8e-25 87.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 ADH_zinc_N PF00107.21 EFW98961.1 - 7e-14 51.4 0.6 1.3e-12 47.3 0.4 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFW98961.1 - 6.8e-06 25.8 0.0 0.00088 19.0 0.0 2.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 EFW98961.1 - 0.0025 17.8 0.4 0.0038 17.2 0.3 1.3 1 0 0 1 1 1 1 NADH(P)-binding ADH_zinc_N_2 PF13602.1 EFW98961.1 - 0.0029 18.4 0.1 0.0061 17.4 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.20 EFW98961.1 - 0.0043 16.9 1.0 0.0073 16.2 0.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Eno-Rase_NADH_b PF12242.3 EFW98961.1 - 0.0077 16.0 0.3 0.022 14.5 0.2 1.9 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.15 EFW98961.1 - 0.012 15.7 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.16 EFW98961.1 - 0.12 11.9 0.7 0.33 10.5 0.1 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Sas10 PF09368.5 EFW98962.1 - 6.6e-22 77.4 8.0 6.6e-22 77.4 5.5 2.9 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 EFW98962.1 - 1.2e-07 31.8 1.5 2.1e-07 31.0 0.0 2.3 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DUF4094 PF13334.1 EFW98962.1 - 1.5 9.2 6.8 8.2 6.8 4.7 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Aldo_ket_red PF00248.16 EFW98963.1 - 2.6e-42 144.6 0.1 3.1e-42 144.3 0.1 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family XH PF03469.9 EFW98963.1 - 0.047 13.3 0.0 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 XH domain Proteasom_PSMB PF10508.4 EFW98964.1 - 0.0039 15.5 0.2 0.44 8.7 0.1 2.2 2 0 0 2 2 2 2 Proteasome non-ATPase 26S subunit p450 PF00067.17 EFW98965.1 - 1.1e-45 156.0 0.0 1.7e-45 155.4 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 HSP20 PF00011.16 EFW98966.1 - 5.9e-16 58.2 0.1 1e-10 41.3 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family Sod_Fe_C PF02777.13 EFW98967.1 - 1.2e-37 127.9 0.4 2.3e-37 127.0 0.2 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EFW98967.1 - 2e-30 104.8 1.2 3.7e-30 104.0 0.8 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Phycobilisome PF00502.14 EFW98968.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome protein Uso1_p115_head PF04869.9 EFW98969.1 - 2.3e-87 292.6 0.0 7e-87 291.0 0.0 1.8 1 1 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Methyltransf_31 PF13847.1 EFW98969.1 - 2.8e-11 43.2 0.0 7.1e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFW98969.1 - 7.7e-11 41.6 0.0 7.7e-11 41.6 0.0 2.6 3 1 0 4 4 4 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 EFW98969.1 - 9.6e-11 42.2 0.5 5.6e-10 39.7 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Uso1_p115_C PF04871.8 EFW98969.1 - 1e-10 41.6 25.4 1e-10 41.6 17.6 4.2 2 1 2 4 4 4 1 Uso1 / p115 like vesicle tethering protein, C terminal region Methyltransf_11 PF08241.7 EFW98969.1 - 1.4e-07 31.8 0.2 1.5e-06 28.5 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW98969.1 - 3.4e-07 30.3 0.0 3.4e-07 30.3 0.0 2.4 2 1 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 EFW98969.1 - 2.6e-06 26.9 0.0 7.5e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 EFW98969.1 - 5.2e-06 26.2 0.0 1.5e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW98969.1 - 0.00012 22.4 0.0 0.0006 20.1 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW98969.1 - 0.00029 21.2 1.7 0.002 18.5 0.0 3.1 3 0 0 3 3 3 1 Methyltransferase domain CMAS PF02353.15 EFW98969.1 - 0.00046 19.3 0.0 0.0011 18.0 0.0 1.6 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.4 EFW98969.1 - 0.0022 17.4 0.0 0.0051 16.2 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.14 EFW98969.1 - 0.0025 17.3 0.0 0.0052 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.6 EFW98969.1 - 0.012 14.3 0.0 0.012 14.3 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1698) TehB PF03848.9 EFW98969.1 - 0.04 13.0 0.1 0.1 11.7 0.1 1.6 1 1 0 1 1 1 0 Tellurite resistance protein TehB DUF1162 PF06650.7 EFW98970.1 - 1.8e-90 302.8 0.1 5.9e-87 291.4 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1162) Chorein_N PF12624.2 EFW98970.1 - 4.6e-43 145.5 0.1 1.6e-42 143.7 0.0 2.1 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter ATG_C PF09333.6 EFW98970.1 - 2e-05 24.6 0.1 8.8e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 ATG C terminal domain zf-CHY PF05495.7 EFW98971.1 - 3.6e-13 49.4 20.8 4.7e-13 49.1 14.4 1.1 1 0 0 1 1 1 1 CHY zinc finger zinc_ribbon_2 PF13240.1 EFW98971.1 - 0.22 11.0 0.1 0.22 11.0 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain HypA PF01155.14 EFW98971.1 - 2.2 8.0 10.4 0.076 12.7 2.4 1.9 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Glyco_hydro_18 PF00704.23 EFW98972.1 - 2.6e-44 152.1 4.8 7.3e-44 150.6 1.6 2.6 3 0 0 3 3 3 1 Glycosyl hydrolases family 18 Hce2 PF14856.1 EFW98972.1 - 9.1e-29 99.2 2.6 9.1e-29 99.2 1.8 2.5 2 0 0 2 2 2 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.15 EFW98972.1 - 1.3e-13 50.6 0.1 5.5e-08 32.5 0.0 2.7 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.14 EFW98972.1 - 0.00078 19.3 4.4 0.00078 19.3 3.1 4.7 5 0 0 5 5 5 1 Chitin recognition protein DUF3142 PF11340.3 EFW98972.1 - 0.02 14.5 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Lipase_3 PF01764.20 EFW98973.1 - 1.6e-05 24.5 0.0 4e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EFW98973.1 - 0.049 13.3 0.0 0.16 11.7 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.7 EFW98973.1 - 0.054 13.2 0.1 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Ribonuclease_3 PF00636.21 EFW98974.1 - 4.3e-14 52.9 0.1 1.2e-13 51.5 0.0 1.8 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EFW98974.1 - 2.1e-09 37.3 0.0 5.4e-09 36.0 0.0 1.7 2 0 0 2 2 2 1 Ribonuclease-III-like dsrm PF00035.20 EFW98974.1 - 0.0074 16.8 0.0 0.017 15.6 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif 2OG-FeII_Oxy PF03171.15 EFW98975.1 - 9.2e-14 51.5 0.0 1.9e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CAP_N PF01213.14 EFW98975.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DIOX_N PF14226.1 EFW98975.1 - 0.14 12.6 0.1 0.37 11.3 0.0 1.7 1 1 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal FAD_binding_3 PF01494.14 EFW98976.1 - 2.3e-21 76.2 0.0 3.3e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 EFW98976.1 - 4e-06 26.7 0.1 1.2e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFW98976.1 - 4e-05 22.6 0.0 0.00016 20.7 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFW98976.1 - 5.2e-05 23.2 0.0 0.00067 19.5 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFW98976.1 - 0.00019 21.7 0.0 0.00062 20.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFW98976.1 - 0.0017 16.9 0.0 0.0028 16.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein SE PF08491.5 EFW98976.1 - 0.0034 16.2 0.0 0.0075 15.1 0.0 1.5 2 0 0 2 2 2 1 Squalene epoxidase FAD_oxidored PF12831.2 EFW98976.1 - 0.01 14.9 0.1 0.03 13.4 0.1 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.17 EFW98976.1 - 0.019 13.8 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.13 EFW98976.1 - 0.035 13.7 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EFW98976.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Glyco_tranf_2_3 PF13641.1 EFW98977.1 - 1.2e-14 54.7 0.2 1.6e-14 54.2 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EFW98977.1 - 1.8e-07 30.6 0.0 3.1e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.1 EFW98977.1 - 0.00032 20.4 5.7 0.00032 20.4 4.0 1.4 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 EFW98977.1 - 0.017 14.7 0.1 0.041 13.5 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase family 2 Cupin_8 PF13621.1 EFW98978.1 - 5e-38 131.0 0.0 8.1e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.9 EFW98978.1 - 2.2e-10 40.3 0.0 1.5e-08 34.4 0.0 2.3 1 1 1 2 2 2 2 Leucine carboxyl methyltransferase Cupin_4 PF08007.7 EFW98978.1 - 0.0057 15.9 0.0 0.0099 15.1 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Kelch_4 PF13418.1 EFW98978.1 - 0.022 14.5 0.1 0.15 11.8 0.1 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain RNA_pol_A_bac PF01000.21 EFW98980.1 - 8.9e-32 109.5 0.0 1.4e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EFW98980.1 - 7.8e-12 44.1 0.0 1e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF3453 PF11935.3 EFW98981.1 - 7.7e-65 218.6 0.0 1.5e-64 217.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) Allantoicase PF03561.10 EFW98982.1 - 8.3e-99 327.2 0.0 2.4e-50 169.9 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat p450 PF00067.17 EFW98984.1 - 2.7e-37 128.3 0.0 4.3e-37 127.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 RGS PF00615.14 EFW98985.1 - 3.9e-10 39.8 0.0 5.5e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Zn_clus PF00172.13 EFW98986.1 - 5.3e-10 39.0 10.5 1.1e-09 38.0 7.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CLN6 PF15156.1 EFW98986.1 - 0.14 11.2 0.0 11 5.0 0.1 2.1 2 0 0 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 6 Reprolysin_5 PF13688.1 EFW98987.1 - 1.5e-54 184.9 9.1 1.5e-54 184.9 6.3 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 EFW98987.1 - 1.4e-42 145.6 3.2 3.2e-42 144.5 2.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 EFW98987.1 - 4.1e-42 144.0 2.4 7.3e-42 143.2 1.6 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 EFW98987.1 - 5.2e-17 62.5 0.2 1.6e-16 60.9 0.1 1.9 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.14 EFW98987.1 - 0.0014 18.4 0.0 0.0033 17.2 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide SKG6 PF08693.5 EFW98987.1 - 0.4 10.0 6.5 0.032 13.5 1.1 1.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF2392 PF10288.4 EFW98988.1 - 6.2e-19 68.3 0.0 3.5e-18 65.8 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2392) Mito_carr PF00153.22 EFW98989.1 - 2e-27 94.6 6.3 2.3e-12 46.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PPTA PF01239.17 EFW98990.1 - 1.3e-33 112.9 9.9 7.6e-09 34.5 0.2 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat Glyco_transf_22 PF03901.12 EFW98991.1 - 1.8e-45 155.7 20.9 2.9e-23 82.5 5.4 2.1 1 1 1 2 2 2 2 Alg9-like mannosyltransferase family ABC_membrane PF00664.18 EFW98992.1 - 6.8e-39 133.9 19.3 1.2e-31 110.2 7.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFW98992.1 - 1e-35 122.9 0.0 1.3e-16 61.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFW98992.1 - 1.1e-06 28.8 0.1 0.0033 17.4 0.1 2.3 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 EFW98992.1 - 1.1e-06 28.0 0.2 0.00026 20.3 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EFW98992.1 - 0.001 18.5 0.1 0.0032 16.9 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFW98992.1 - 0.0014 18.6 0.0 0.0096 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 EFW98992.1 - 0.002 17.3 0.2 0.0092 15.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFW98992.1 - 0.0068 17.2 0.0 0.034 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.4 EFW98992.1 - 0.011 14.3 0.5 0.028 13.0 0.1 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_18 PF13238.1 EFW98992.1 - 0.024 14.9 0.0 0.05 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 EFW98992.1 - 0.045 13.6 0.1 0.19 11.6 0.1 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.1 EFW98992.1 - 0.1 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 EFW98992.1 - 0.12 12.1 0.0 0.9 9.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Trypan_PARP PF05887.6 EFW98992.1 - 0.22 11.3 0.1 0.46 10.3 0.1 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) XRN_N PF03159.13 EFW98993.1 - 9.7e-74 247.7 0.1 9e-64 215.0 0.0 2.6 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus RasGAP PF00616.14 EFW98993.1 - 5.6e-44 150.1 0.0 1e-43 149.3 0.0 1.5 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.1 EFW98993.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain tRNA-synt_2b PF00587.20 EFW98994.1 - 5.6e-46 156.2 0.0 7.9e-46 155.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFW98994.1 - 8.7e-07 28.8 0.0 1.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain PPR_2 PF13041.1 EFW98995.1 - 1.3e-14 53.8 0.0 0.00014 21.7 0.0 6.6 6 1 2 8 8 8 4 PPR repeat family PPR PF01535.15 EFW98995.1 - 4.4e-14 51.3 0.0 0.43 10.6 0.0 8.2 9 0 0 9 9 9 4 PPR repeat PPR_3 PF13812.1 EFW98995.1 - 1.2e-12 47.0 20.1 0.47 10.8 0.0 11.3 11 0 0 11 11 11 4 Pentatricopeptide repeat domain PPR_1 PF12854.2 EFW98995.1 - 1.1e-05 24.7 0.5 0.093 12.2 0.0 4.7 5 0 0 5 5 5 1 PPR repeat TPR_14 PF13428.1 EFW98995.1 - 0.019 15.5 28.9 4.7 8.1 0.3 9.8 9 2 2 11 11 11 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFW98995.1 - 7.1 7.3 14.1 11 6.7 1.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3445 PF11927.3 EFW98997.1 - 1.7e-60 204.5 0.0 2e-60 204.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Peptidase_M3 PF01432.15 EFW98998.1 - 8.3e-25 87.7 0.1 2.6e-13 49.8 0.0 2.1 1 1 1 2 2 2 2 Peptidase family M3 E1-E2_ATPase PF00122.15 EFW98999.1 - 9.1e-65 217.9 6.9 2.3e-64 216.5 4.8 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EFW98999.1 - 5.9e-23 82.4 0.0 1.2e-22 81.3 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFW98999.1 - 2.3e-13 50.7 0.0 6.7e-13 49.2 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFW98999.1 - 4e-10 39.0 0.8 3.7e-09 35.9 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EFW98999.1 - 0.0012 18.4 0.1 0.0028 17.2 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFW98999.1 - 0.083 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit Sugar_tr PF00083.19 EFW99000.1 - 1.9e-100 336.6 19.0 2.2e-100 336.3 13.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFW99000.1 - 2.2e-24 85.8 36.0 5.1e-23 81.3 21.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Innate_immun PF12782.2 EFW99000.1 - 0.19 10.9 4.6 0.29 10.3 3.2 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Peptidase_S8 PF00082.17 EFW99001.1 - 7e-22 77.8 0.1 1.2e-21 77.0 0.1 1.4 1 0 0 1 1 1 1 Subtilase family Patatin PF01734.17 EFW99001.1 - 2.9e-06 27.3 0.3 1.2e-05 25.3 0.2 2.1 2 1 0 2 2 2 1 Patatin-like phospholipase Pex16 PF08610.5 EFW99002.1 - 0.38 9.6 2.6 0.74 8.7 1.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Nop14 PF04147.7 EFW99002.1 - 2.1 6.1 9.1 3 5.6 6.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF912 PF06024.7 EFW99002.1 - 2.3 8.2 5.4 6.4 6.8 3.7 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Cu_amine_oxid PF01179.15 EFW99003.1 - 3.2e-156 520.2 0.0 3.9e-156 519.9 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 EFW99003.1 - 6.9e-08 32.4 1.2 3.1e-07 30.3 0.1 2.5 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.11 EFW99003.1 - 2.4e-06 27.4 0.0 5.1e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain PAN_1 PF00024.21 EFW99004.1 - 1.1 9.0 4.8 1.5 8.5 3.3 1.3 1 0 0 1 1 1 0 PAN domain DUF1640 PF07798.6 EFW99005.1 - 5.4e-09 36.3 1.3 8.4e-09 35.7 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Transferase PF02458.10 EFW99006.1 - 5.8e-05 21.7 0.0 0.00026 19.5 0.0 1.7 1 1 0 1 1 1 1 Transferase family FAM198 PF15051.1 EFW99006.1 - 0.036 12.7 0.0 0.071 11.7 0.0 1.4 2 0 0 2 2 2 0 FAM198 protein PhnG PF06754.7 EFW99006.1 - 0.084 12.4 0.2 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnG MCR_beta PF02241.13 EFW99006.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain Mob1_phocein PF03637.12 EFW99007.1 - 1.8e-69 232.8 0.0 2.3e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family AA_permease PF00324.16 EFW99008.1 - 1.1e-75 254.7 32.5 1.3e-75 254.5 22.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFW99008.1 - 1.7e-24 86.2 33.7 2.2e-24 85.7 23.3 1.2 1 0 0 1 1 1 1 Amino acid permease DUF543 PF04418.7 EFW99009.1 - 3e-28 97.5 0.0 3.2e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) DUF2456 PF10445.4 EFW99009.1 - 0.063 13.2 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) Mus7 PF09462.5 EFW99010.1 - 1.1e-134 450.5 0.3 1.7e-134 450.0 0.2 1.3 1 0 0 1 1 1 1 Mus7/MMS22 family zf-C2H2_4 PF13894.1 EFW99010.1 - 0.0013 18.9 9.9 3 8.4 0.2 4.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFW99010.1 - 0.6 10.3 2.0 4.6 7.5 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.13 EFW99010.1 - 0.7 10.3 2.6 1.8 9.0 1.8 1.7 1 0 0 1 1 1 0 TRAF-type zinc finger zf-C2H2 PF00096.21 EFW99010.1 - 1.5 9.3 18.6 0.15 12.4 0.4 4.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type EzrA PF06160.7 EFW99010.1 - 5.5 5.0 0.0 9.3 4.2 0.0 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA MOR2-PAG1_N PF14222.1 EFW99012.1 - 3.6e-195 649.8 0.0 1.3e-194 647.9 0.0 1.9 2 0 0 2 2 2 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 EFW99012.1 - 5.6e-79 265.5 0.3 1.8e-78 263.9 0.0 2.1 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 EFW99012.1 - 4.4e-27 94.1 10.0 1.2e-07 29.7 0.5 6.0 3 1 2 6 6 6 5 Cell morphogenesis central region Zip PF02535.17 EFW99012.1 - 0.034 13.1 2.2 0.24 10.3 0.9 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2722 PF10846.3 EFW99013.1 - 1.7e-06 27.3 5.6 3e-06 26.5 2.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) HET PF06985.6 EFW99014.1 - 7.1e-24 84.5 0.0 1.5e-23 83.4 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_C48 PF02902.14 EFW99015.1 - 3e-20 72.7 0.0 4.8e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain CAF-1_p150 PF11600.3 EFW99015.1 - 2.6e-05 23.6 8.4 5.4e-05 22.6 5.8 1.4 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Spindle_Spc25 PF08234.7 EFW99016.1 - 1.1e-20 73.4 0.0 2.1e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Macoilin PF09726.4 EFW99016.1 - 0.024 12.9 9.3 0.03 12.6 6.5 1.1 1 0 0 1 1 1 0 Transmembrane protein HAT PF02184.11 EFW99016.1 - 0.064 13.0 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 HAT (Half-A-TPR) repeat SLA_LP_auto_ag PF05889.8 EFW99016.1 - 0.083 11.3 0.9 0.12 10.8 0.6 1.3 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) FMN_dh PF01070.13 EFW99018.1 - 4.9e-107 357.8 0.0 6e-107 357.5 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 EFW99018.1 - 0.0001 21.3 0.0 0.00015 20.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 EFW99018.1 - 0.00091 18.4 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFW99018.1 - 0.0012 17.7 1.2 0.0059 15.5 0.3 2.0 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.16 EFW99018.1 - 0.12 11.2 0.2 1.2 8.0 0.0 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase DAG1 PF05454.6 EFW99019.1 - 0.04 13.0 0.2 0.064 12.4 0.1 1.3 1 1 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Elong-fact-P_C PF09285.6 EFW99021.1 - 0.025 13.9 0.1 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P, C-terminal Augurin PF15187.1 EFW99021.1 - 3.1 7.7 5.1 16 5.3 0.6 2.2 1 1 0 2 2 2 0 Oesophageal cancer-related gene 4 2OG-FeII_Oxy_2 PF13532.1 EFW99022.1 - 4.7e-28 98.3 0.0 7.1e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.7 EFW99022.1 - 3.7e-09 36.3 2.3 6.8e-09 35.5 1.6 1.4 1 0 0 1 1 1 1 GRF zinc finger 2OG-FeII_Oxy PF03171.15 EFW99022.1 - 0.0019 18.4 0.1 0.0085 16.3 0.1 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1040 PF06288.8 EFW99023.1 - 0.15 12.3 0.0 15 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1040) UbiA PF01040.13 EFW99024.1 - 3e-32 111.8 21.2 4e-32 111.4 14.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Amidase PF01425.16 EFW99025.1 - 1.9e-63 214.8 1.8 4.5e-63 213.6 1.3 1.7 1 0 0 1 1 1 1 Amidase Clr5 PF14420.1 EFW99025.1 - 2.5e-21 75.3 0.8 5.5e-21 74.2 0.2 1.9 2 0 0 2 2 2 1 Clr5 domain Rad60-SLD_2 PF13881.1 EFW99025.1 - 0.094 12.6 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF1793 PF08760.6 EFW99025.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1793) SET PF00856.23 EFW99026.1 - 8.8e-20 71.6 0.2 8.8e-20 71.6 0.1 2.9 2 0 0 2 2 2 1 SET domain IKI3 PF04762.7 EFW99027.1 - 5.7e-281 934.5 0.0 1e-280 933.7 0.0 1.4 2 0 0 2 2 2 1 IKI3 family DUF1014 PF06244.7 EFW99028.1 - 1.3e-22 80.3 7.3 2.9e-22 79.1 5.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) DUF4551 PF15087.1 EFW99028.1 - 0.32 9.2 4.1 0.4 8.9 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hamartin PF04388.7 EFW99028.1 - 0.65 8.5 6.1 0.71 8.4 4.2 1.2 1 0 0 1 1 1 0 Hamartin protein SET PF00856.23 EFW99029.1 - 0.00017 21.9 0.0 0.00039 20.7 0.0 1.6 1 0 0 1 1 1 1 SET domain Phosphodiest PF01663.17 EFW99030.1 - 3.7e-11 42.9 0.2 7.6e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFW99030.1 - 1.9e-05 24.0 0.0 5.1e-05 22.6 0.0 1.6 1 1 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.13 EFW99030.1 - 0.00015 21.2 0.1 0.00027 20.3 0.1 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily adh_short PF00106.20 EFW99031.1 - 2.9e-21 76.1 2.4 4.3e-21 75.5 1.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFW99031.1 - 1.2e-09 38.0 1.0 2.7e-09 36.9 0.7 1.5 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFW99031.1 - 6e-06 26.1 0.0 8.6e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFW99031.1 - 4.5e-05 23.5 1.9 0.00012 22.1 1.0 1.8 2 1 0 2 2 2 1 NADH(P)-binding Shikimate_DH PF01488.15 EFW99031.1 - 0.0017 18.4 0.4 0.0032 17.5 0.3 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase CoA_binding_2 PF13380.1 EFW99031.1 - 0.0033 17.5 0.3 0.01 15.9 0.2 1.9 1 0 0 1 1 1 1 CoA binding domain THF_DHG_CYH_C PF02882.14 EFW99031.1 - 0.0035 16.4 1.4 0.22 10.5 0.1 2.2 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain F420_oxidored PF03807.12 EFW99031.1 - 0.0063 16.9 0.1 0.054 13.9 0.2 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Eno-Rase_NADH_b PF12242.3 EFW99031.1 - 0.036 13.8 0.7 0.082 12.6 0.5 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NmrA PF05368.8 EFW99031.1 - 0.036 13.2 0.2 0.085 12.0 0.1 1.6 2 0 0 2 2 2 0 NmrA-like family Epimerase PF01370.16 EFW99031.1 - 0.045 13.1 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_transf_4 PF13439.1 EFW99031.1 - 0.074 12.7 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 NAD_binding_7 PF13241.1 EFW99031.1 - 0.14 12.4 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding DFP PF04127.10 EFW99031.1 - 0.2 11.2 0.9 0.35 10.4 0.6 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein AMP-binding_C PF13193.1 EFW99031.1 - 0.58 11.1 2.3 4.9 8.1 0.1 2.9 3 1 0 3 3 2 0 AMP-binding enzyme C-terminal domain ECH PF00378.15 EFW99032.1 - 2.6e-26 92.2 0.0 3e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Npa1 PF11707.3 EFW99033.1 - 1.3e-78 264.2 0.0 1.8e-78 263.8 0.0 1.2 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Glycos_transf_1 PF00534.15 EFW99034.1 - 2.8e-21 75.7 0.0 5.1e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFW99034.1 - 5.5e-09 36.2 0.0 2e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EFW99034.1 - 0.019 15.1 0.0 0.092 13.0 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 Peptidase_M3 PF01432.15 EFW99035.1 - 4.9e-100 335.7 0.0 6.7e-100 335.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Mito_carr PF00153.22 EFW99036.1 - 5.5e-61 202.2 3.7 1.6e-23 82.2 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.27 EFW99036.1 - 3.6e-21 72.7 2.8 1.5e-06 27.1 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 EFW99036.1 - 2e-19 69.4 3.9 2.1e-11 43.7 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EFW99036.1 - 3.7e-18 63.9 4.1 3.7e-06 26.0 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 EFW99036.1 - 2.2e-17 62.3 3.8 4.7e-06 26.1 0.1 3.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 EFW99036.1 - 8.5e-13 47.0 12.5 0.00032 20.3 0.4 4.1 4 0 0 4 4 4 3 EF-hand domain SPARC_Ca_bdg PF10591.4 EFW99036.1 - 1.9e-07 31.0 0.0 0.001 19.0 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 EFW99036.1 - 0.0036 17.0 0.3 0.041 13.6 0.1 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Fungal_trans PF04082.13 EFW99037.1 - 8.6e-10 37.9 0.0 1.3e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW99037.1 - 6.7e-07 29.1 9.3 1.3e-06 28.2 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3138 PF11336.3 EFW99037.1 - 0.17 10.0 6.3 0.53 8.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) HATPase_c PF02518.21 EFW99038.1 - 3.8e-28 97.4 0.0 8e-28 96.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EFW99038.1 - 9.4e-23 80.3 0.1 2.1e-22 79.2 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EFW99038.1 - 9.6e-19 67.1 0.9 9.6e-19 67.1 0.7 2.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.1 EFW99038.1 - 3.3e-14 53.2 0.0 2.4e-13 50.4 0.0 2.5 2 1 0 2 2 1 1 AAA ATPase domain GAF_2 PF13185.1 EFW99038.1 - 3.3e-11 43.8 0.0 8.2e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.1 EFW99038.1 - 1.3e-08 34.9 0.0 3.5e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.20 EFW99038.1 - 5.9e-08 32.1 0.0 1.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain TPR_8 PF13181.1 EFW99038.1 - 0.00014 21.3 1.4 0.023 14.4 0.0 3.7 3 0 0 3 3 2 1 Tetratricopeptide repeat AAA_22 PF13401.1 EFW99038.1 - 0.00059 19.9 0.9 0.12 12.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain Pkinase_Tyr PF07714.12 EFW99038.1 - 0.00084 18.4 0.0 0.0022 17.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase ArgK PF03308.11 EFW99038.1 - 0.0034 16.1 0.1 0.015 14.0 0.1 1.9 2 0 0 2 2 2 1 ArgK protein HATPase_c_3 PF13589.1 EFW99038.1 - 0.0058 16.2 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NACHT PF05729.7 EFW99038.1 - 0.012 15.3 0.1 0.35 10.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain TPR_19 PF14559.1 EFW99038.1 - 0.017 15.4 2.3 0.086 13.1 0.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFW99038.1 - 0.041 13.7 6.4 31 4.8 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Gasdermin PF04598.7 EFW99038.1 - 0.31 9.7 3.3 0.39 9.4 0.0 2.1 2 0 0 2 2 2 0 Gasdermin family Pkinase PF00069.20 EFW99039.1 - 1.6e-11 43.8 0.0 3.9e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99039.1 - 4e-05 22.8 0.0 0.00012 21.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99039.1 - 0.068 12.1 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like ATG11 PF10377.4 EFW99040.1 - 9.3e-40 135.5 0.0 3.7e-39 133.5 0.0 2.2 1 0 0 1 1 1 1 Autophagy-related protein 11 Transposase_24 PF03004.9 EFW99040.1 - 0.0012 18.7 10.6 0.0032 17.3 3.3 3.3 2 1 0 2 2 2 1 Plant transposase (Ptta/En/Spm family) Mt_ATP-synt_D PF05873.7 EFW99040.1 - 0.028 14.0 0.4 0.13 11.8 0.3 2.2 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) DUF3461 PF11944.3 EFW99040.1 - 5 6.9 9.4 11 5.8 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF3461) Fungal_trans_2 PF11951.3 EFW99042.1 - 3.7e-14 52.1 1.5 1.3e-13 50.3 0.1 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW99042.1 - 1.2e-06 28.2 12.6 2e-06 27.5 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vps39_2 PF10367.4 EFW99042.1 - 0.82 9.8 4.2 2.4 8.3 2.9 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Daxx PF03344.10 EFW99042.1 - 0.99 7.8 8.5 1.5 7.2 5.9 1.2 1 0 0 1 1 1 0 Daxx Family Myb_DNA-binding PF00249.26 EFW99043.1 - 5.9e-11 42.2 3.6 1.2e-08 34.8 0.1 2.7 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFW99043.1 - 4.9e-06 26.5 4.5 0.00035 20.6 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain PAP_central PF04928.12 EFW99044.1 - 3.1e-100 334.1 0.0 4e-100 333.8 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 EFW99044.1 - 7.1e-42 142.5 0.0 1.2e-41 141.8 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 EFW99044.1 - 1.3e-07 31.8 0.0 3.3e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap PF03813.9 EFW99044.1 - 0.049 11.1 0.0 0.087 10.3 0.0 1.3 1 0 0 1 1 1 0 Nrap protein Aa_trans PF01490.13 EFW99045.1 - 3.1e-71 240.0 25.1 4e-71 239.6 17.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Asp PF00026.18 EFW99045.1 - 2.7e-56 191.1 10.6 4e-56 190.5 7.3 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFW99045.1 - 1.3e-08 34.9 1.3 3.1e-08 33.7 0.4 2.2 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal MFS_1 PF07690.11 EFW99046.1 - 2.6e-37 128.3 14.0 2.6e-37 128.3 9.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFW99046.1 - 1.9e-09 36.6 4.4 1.9e-09 36.6 3.1 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 EFW99046.1 - 3.2e-08 32.4 15.3 7.2e-06 24.6 1.9 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 EFW99046.1 - 0.00089 18.9 5.8 0.2 11.4 0.0 4.0 2 1 1 3 3 3 2 MFS_1 like family Nuc_H_symport PF03825.11 EFW99046.1 - 0.0024 16.6 1.4 0.0074 15.1 1.0 1.8 1 0 0 1 1 1 1 Nucleoside H+ symporter TRI12 PF06609.8 EFW99046.1 - 0.011 13.9 0.9 0.016 13.4 0.6 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFW99046.1 - 0.067 11.3 5.3 0.24 9.4 1.0 2.3 2 0 0 2 2 2 0 Transmembrane secretion effector Thymidylat_synt PF00303.14 EFW99047.1 - 1.3e-113 378.5 0.0 1.4e-113 378.3 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase VPS9 PF02204.13 EFW99049.1 - 1.2e-21 76.7 0.0 2e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CNH PF00780.17 EFW99050.1 - 4e-78 262.6 0.0 1.1e-77 261.2 0.0 1.6 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 EFW99050.1 - 5e-43 146.2 0.0 1e-42 145.3 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.15 EFW99050.1 - 1.7e-35 122.5 0.0 3.1e-35 121.6 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.16 EFW99050.1 - 4.8e-14 51.8 0.0 8.8e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Coiled-coil_56 PF09813.4 EFW99052.1 - 5.8e-05 23.0 0.1 7.7e-05 22.6 0.1 1.3 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 56 Ribosomal_L16 PF00252.13 EFW99053.1 - 1.4e-29 102.5 0.4 2e-29 102.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Aminotran_5 PF00266.14 EFW99054.1 - 6.7e-23 81.0 0.0 9.3e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.14 EFW99054.1 - 0.004 17.0 0.1 0.027 14.3 0.0 2.1 2 0 0 2 2 2 1 B12 binding domain Transferase PF02458.10 EFW99055.1 - 9e-30 103.4 0.0 6.1e-26 90.8 0.0 3.1 1 1 0 1 1 1 1 Transferase family DEAD PF00270.24 EFW99056.1 - 6.6e-41 139.6 0.1 2.3e-40 137.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99056.1 - 5.6e-19 67.7 0.1 1.4e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW99056.1 - 0.068 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit adh_short PF00106.20 EFW99057.1 - 5.8e-28 97.8 0.1 8.4e-28 97.3 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFW99057.1 - 5.3e-12 45.7 0.2 8e-12 45.1 0.1 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFW99057.1 - 2e-10 40.8 0.0 2.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 EFW99057.1 - 9.6e-06 25.3 0.6 2.8e-05 23.8 0.3 1.8 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.14 EFW99057.1 - 0.015 14.4 0.0 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Polysacc_synt_2 PF02719.10 EFW99057.1 - 0.032 13.1 0.0 0.041 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Rep_fac_C PF08542.6 EFW99058.1 - 3.4e-21 75.0 0.0 7.7e-21 73.8 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EFW99058.1 - 1.1e-10 41.4 0.0 2.1e-10 40.5 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 EFW99058.1 - 3.1e-06 27.3 0.3 3e-05 24.1 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 EFW99058.1 - 1.2e-05 25.5 0.1 2.4e-05 24.5 0.1 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EFW99058.1 - 0.00018 21.3 0.1 0.00038 20.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFW99058.1 - 0.00029 20.8 3.9 0.046 13.7 2.7 3.3 1 1 0 1 1 1 1 AAA ATPase domain SNF2_N PF00176.18 EFW99058.1 - 0.0059 15.4 0.1 0.0084 14.9 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Sigma54_activ_2 PF14532.1 EFW99058.1 - 0.0072 16.3 0.1 0.23 11.4 0.1 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain ABC_tran PF00005.22 EFW99058.1 - 0.02 15.2 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter T4SS-DNA_transf PF02534.9 EFW99058.1 - 0.022 13.3 0.1 0.095 11.2 0.0 1.8 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer AAA_10 PF12846.2 EFW99058.1 - 0.031 13.7 0.2 2.1 7.7 0.0 2.3 1 1 0 2 2 2 0 AAA-like domain Rad17 PF03215.10 EFW99058.1 - 0.049 12.3 0.0 0.063 11.9 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 EFW99058.1 - 0.12 12.0 0.0 0.29 10.8 0.0 1.7 1 1 0 1 1 1 0 Archaeal ATPase AAA_5 PF07728.9 EFW99058.1 - 0.2 11.3 0.7 0.88 9.3 0.5 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) zf-C3HC4 PF00097.20 EFW99059.1 - 1.5e-07 30.9 4.9 1.5e-07 30.9 3.4 4.8 6 0 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFW99059.1 - 7.3e-07 28.9 5.8 7.3e-07 28.9 4.0 4.2 4 2 0 4 4 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFW99059.1 - 9.2e-07 28.7 1.9 9.2e-07 28.7 1.3 4.8 4 3 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 EFW99059.1 - 2.3e-06 27.3 0.3 2.3e-06 27.3 0.2 3.1 3 0 0 3 3 3 1 zf-RING of BARD1-type protein SH3_9 PF14604.1 EFW99059.1 - 1.7e-05 24.3 0.2 1.7e-05 24.3 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain zf-RING_5 PF14634.1 EFW99059.1 - 5.4e-05 22.8 4.3 5.4e-05 22.8 3.0 4.8 6 0 0 6 6 4 1 zinc-RING finger domain SH3_1 PF00018.23 EFW99059.1 - 8.6e-05 21.8 0.0 0.00017 20.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain zf-C3HC4_4 PF15227.1 EFW99059.1 - 0.00051 19.8 4.5 0.00051 19.8 3.1 3.7 4 2 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFW99059.1 - 0.0034 17.0 1.7 0.0088 15.7 1.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger SH3_2 PF07653.12 EFW99059.1 - 0.071 12.6 0.2 0.15 11.5 0.1 1.5 1 0 0 1 1 1 0 Variant SH3 domain HypA PF01155.14 EFW99059.1 - 5 6.8 13.0 1.7 8.3 0.3 3.6 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family Ribosomal_L9_N PF01281.14 EFW99060.1 - 1.3e-06 27.4 0.0 2.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain CHAD PF05235.9 EFW99060.1 - 0.00015 21.4 0.1 0.00021 20.9 0.1 1.2 1 0 0 1 1 1 1 CHAD domain Ribosomal_L9_C PF03948.9 EFW99060.1 - 0.0061 16.6 0.0 0.09 12.8 0.0 2.5 3 0 0 3 3 3 1 Ribosomal protein L9, C-terminal domain BCDHK_Adom3 PF10436.4 EFW99061.1 - 4.4e-68 227.9 0.0 6.4e-68 227.4 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EFW99061.1 - 3.1e-17 62.2 0.0 6.7e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFW99061.1 - 0.034 13.8 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aminotran_3 PF00202.16 EFW99062.1 - 6.6e-51 173.1 0.0 9.8e-51 172.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III OST3_OST6 PF04756.8 EFW99063.1 - 5.1e-22 78.1 1.2 8.6e-22 77.4 0.8 1.3 1 0 0 1 1 1 1 OST3 / OST6 family Acyl_transf_1 PF00698.16 EFW99063.1 - 4.7e-18 65.5 0.7 1.2e-14 54.3 0.2 2.5 3 0 0 3 3 3 2 Acyl transferase domain zf-RING_2 PF13639.1 EFW99063.1 - 3.5e-09 36.3 7.7 0.00015 21.5 1.4 2.8 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.1 EFW99063.1 - 7.5e-09 35.4 13.1 8.2e-05 22.5 1.3 2.8 3 0 0 3 3 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFW99063.1 - 6e-06 25.8 10.5 0.0014 18.2 2.1 2.9 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFW99063.1 - 1.6e-05 24.4 7.6 0.0014 18.2 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFW99063.1 - 1.7e-05 24.4 4.1 3.4e-05 23.4 0.2 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 EFW99063.1 - 0.00012 21.7 2.8 0.00012 21.7 1.9 3.1 2 2 0 2 2 2 1 zinc-RING finger domain FYVE PF01363.16 EFW99063.1 - 0.0011 18.7 7.2 0.0017 18.2 1.7 2.7 2 0 0 2 2 2 1 FYVE zinc finger Rtf2 PF04641.7 EFW99063.1 - 0.0024 17.1 5.8 0.79 8.8 3.2 2.9 2 1 0 2 2 2 2 Rtf2 RING-finger Rad50_zn_hook PF04423.9 EFW99063.1 - 0.0031 16.9 2.6 0.13 11.7 0.3 2.5 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C3HC4_4 PF15227.1 EFW99063.1 - 0.014 15.2 12.1 0.58 10.0 1.5 3.3 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Thioredoxin PF00085.15 EFW99063.1 - 0.029 14.0 0.0 0.078 12.6 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin zf-RING_4 PF14570.1 EFW99063.1 - 0.59 9.7 5.4 0.13 11.8 0.1 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.7 EFW99063.1 - 8.4 6.2 12.8 5.8 6.7 0.8 3.0 3 0 0 3 3 3 0 zinc-ribbons NDUF_B12 PF08122.7 EFW99064.1 - 3e-16 58.8 1.9 4.4e-16 58.3 1.3 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Zn_clus PF00172.13 EFW99065.1 - 8.4e-08 31.9 13.5 1.8e-07 30.9 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PXA PF02194.10 EFW99066.1 - 7.2e-31 107.1 0.0 2.3e-30 105.5 0.0 1.9 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.7 EFW99066.1 - 6.1e-17 61.7 1.2 1.7e-16 60.3 0.0 2.5 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.19 EFW99066.1 - 0.00049 19.8 0.0 0.0087 15.8 0.0 2.5 2 0 0 2 2 2 1 PX domain UNC-93 PF05978.11 EFW99067.1 - 3.3e-06 26.6 7.6 7.8e-06 25.4 5.3 1.7 1 1 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 EFW99067.1 - 1.4e-05 24.0 31.2 1.4e-05 24.0 21.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily EMP24_GP25L PF01105.19 EFW99068.1 - 1.3e-52 178.1 0.0 1.5e-52 178.0 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2846 PF11008.3 EFW99068.1 - 0.064 13.0 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2846) SecE PF00584.15 EFW99069.1 - 4.2e-12 45.4 0.1 4.7e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Kei1 PF08552.6 EFW99071.1 - 3e-45 154.1 5.0 5.8e-45 153.2 3.4 1.4 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 K-cyclin_vir_C PF09080.5 EFW99071.1 - 1 9.5 7.6 1.3 9.2 3.7 2.1 1 1 1 2 2 2 0 K cyclin, C terminal SPC12 PF06645.8 EFW99071.1 - 2.6 7.8 9.0 0.36 10.6 2.4 2.4 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) SH3_9 PF14604.1 EFW99072.1 - 5e-13 48.4 0.0 1.1e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.12 EFW99072.1 - 8.5e-13 47.9 0.0 1.4e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.23 EFW99072.1 - 8.9e-12 44.2 0.0 1.8e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.24 EFW99072.1 - 1.2e-07 31.8 0.0 3.1e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EFW99072.1 - 9.6e-06 25.8 0.1 3e-05 24.2 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_2 PF07653.12 EFW99072.1 - 0.00021 20.6 0.0 0.00044 19.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.25 EFW99072.1 - 0.006 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Agenet PF05641.7 EFW99072.1 - 0.12 12.5 0.0 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Agenet domain Glyco_hydro_61 PF03443.9 EFW99073.1 - 0.0031 17.3 2.2 0.0075 16.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 TFIIA PF03153.8 EFW99073.1 - 8.2 6.2 8.1 12 5.6 5.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NAD_binding_4 PF07993.7 EFW99074.1 - 2e-41 141.5 0.0 3.2e-41 140.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 EFW99074.1 - 1.1e-35 122.8 0.0 2.2e-35 121.9 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Fungal_trans PF04082.13 EFW99074.1 - 2.2e-27 95.5 0.1 4.1e-27 94.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Epimerase PF01370.16 EFW99074.1 - 7.1e-15 55.0 0.0 1.4e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Zn_clus PF00172.13 EFW99074.1 - 1.4e-07 31.3 10.8 1.4e-07 31.3 7.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PP-binding PF00550.20 EFW99074.1 - 2e-07 31.1 0.1 2.4e-06 27.7 0.0 2.6 2 0 0 2 2 2 1 Phosphopantetheine attachment site KR PF08659.5 EFW99074.1 - 2.8e-05 23.8 0.5 8.4e-05 22.3 0.3 1.7 1 1 0 1 1 1 1 KR domain adh_short PF00106.20 EFW99074.1 - 0.00013 21.9 0.2 0.00043 20.2 0.1 2.0 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.14 EFW99074.1 - 0.0015 17.2 0.0 0.0069 15.1 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 EFW99074.1 - 0.05 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Rib_5-P_isom_A PF06026.9 EFW99075.1 - 2.6e-42 144.0 0.0 1.4e-40 138.3 0.0 2.1 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DUF830 PF05708.7 EFW99075.1 - 0.032 14.2 0.0 0.063 13.2 0.0 1.5 2 0 0 2 2 2 0 Orthopoxvirus protein of unknown function (DUF830) ABC_membrane PF00664.18 EFW99076.1 - 1.2e-85 287.2 33.9 6.5e-43 147.1 6.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFW99076.1 - 6.9e-68 227.2 0.0 6.3e-33 113.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFW99076.1 - 3.4e-12 46.0 0.0 0.0012 18.1 0.0 3.9 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFW99076.1 - 1.4e-09 38.3 0.7 0.86 9.5 0.0 4.2 3 1 1 4 4 4 3 AAA domain AAA_29 PF13555.1 EFW99076.1 - 1.6e-08 33.9 3.2 0.0003 20.2 0.1 3.6 4 0 0 4 4 3 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 EFW99076.1 - 2.2e-07 29.8 3.3 0.014 14.0 0.1 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_17 PF13207.1 EFW99076.1 - 2.4e-06 28.3 0.0 0.13 13.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFW99076.1 - 4.8e-06 26.6 5.3 0.0087 16.0 0.2 3.6 2 2 1 3 3 3 2 AAA ATPase domain DUF258 PF03193.11 EFW99076.1 - 1.7e-05 24.0 0.1 0.13 11.4 0.0 2.7 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 EFW99076.1 - 0.00034 20.0 1.2 0.63 9.4 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFW99076.1 - 0.00042 20.4 0.7 3 8.0 0.0 3.8 3 1 0 3 3 3 2 AAA domain SbcCD_C PF13558.1 EFW99076.1 - 0.00082 19.2 2.0 0.85 9.5 0.1 3.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 EFW99076.1 - 0.0025 17.7 0.1 0.8 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFW99076.1 - 0.0035 17.2 0.0 5 7.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.12 EFW99076.1 - 0.0045 16.8 0.2 3.6 7.3 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_14 PF13173.1 EFW99076.1 - 0.0045 16.8 0.0 7.9 6.3 0.0 3.5 4 0 0 4 4 4 0 AAA domain AAA_5 PF07728.9 EFW99076.1 - 0.0057 16.3 0.1 5.7 6.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EFW99076.1 - 0.0059 16.9 0.0 5.3 7.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.15 EFW99076.1 - 0.024 13.3 0.0 2.8 6.5 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit DUF815 PF05673.8 EFW99076.1 - 0.043 12.7 0.0 8.9 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_23 PF13476.1 EFW99076.1 - 0.056 13.7 0.0 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 EFW99076.1 - 0.069 12.8 0.1 1.8 8.1 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase MobB PF03205.9 EFW99076.1 - 0.091 12.4 0.7 15 5.2 0.0 3.1 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EFW99076.1 - 0.096 12.1 3.0 13 5.1 0.2 3.5 4 0 0 4 4 4 0 AAA-like domain MMR_HSR1 PF01926.18 EFW99076.1 - 0.24 11.3 0.8 15 5.6 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase zf-H2C2_2 PF13465.1 EFW99077.1 - 5.7e-08 32.6 10.2 1.2e-06 28.4 0.9 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFW99077.1 - 6e-07 29.4 22.8 9.7e-05 22.4 1.1 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.2 EFW99077.1 - 0.0034 17.5 2.0 0.02 15.0 0.4 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EFW99077.1 - 0.0045 17.2 19.5 0.01 16.1 1.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFW99077.1 - 0.078 13.1 0.2 0.078 13.1 0.1 3.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Pex16 PF08610.5 EFW99077.1 - 4.8 6.0 5.7 8.1 5.3 4.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) ADIP PF11559.3 EFW99078.1 - 6e-39 133.3 1.1 6e-39 133.3 0.8 2.7 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding F-box PF00646.28 EFW99078.1 - 5e-07 29.2 1.3 1.7e-06 27.5 0.2 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EFW99078.1 - 0.0002 21.0 0.5 0.00047 19.8 0.3 1.7 1 0 0 1 1 1 1 F-box-like TPR_11 PF13414.1 EFW99078.1 - 0.00037 20.0 0.1 0.0017 17.9 0.1 2.1 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 EFW99078.1 - 0.00095 19.7 2.3 0.00095 19.7 1.6 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFW99078.1 - 0.0011 19.3 2.6 0.0011 19.3 1.8 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat CENP-B_dimeris PF09026.5 EFW99078.1 - 0.034 14.3 34.3 0.014 15.6 5.7 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain GET2 PF08690.5 EFW99078.1 - 2.1 7.5 10.0 4.8 6.3 6.9 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 DASH_Hsk3 PF08227.6 EFW99079.1 - 1.8e-14 53.6 4.0 3.2e-14 52.8 2.7 1.4 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like GIT_SHD PF08518.6 EFW99081.1 - 6.6e-23 79.7 4.2 4.3e-13 48.3 1.0 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Filament PF00038.16 EFW99081.1 - 0.0037 16.7 30.4 0.06 12.8 3.4 2.3 2 0 0 2 2 2 2 Intermediate filament protein SlyX PF04102.7 EFW99081.1 - 0.029 14.7 29.4 0.41 11.0 0.1 5.2 3 1 1 4 4 4 0 SlyX FUSC PF04632.7 EFW99081.1 - 0.2 10.0 17.9 0.43 8.9 12.4 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-Q PF13094.1 EFW99081.1 - 0.4 10.6 36.8 1.2 9.1 13.5 4.6 4 1 0 4 4 4 0 CENP-Q, a CENPA-CAD centromere complex subunit TPR_MLP1_2 PF07926.7 EFW99081.1 - 1 9.0 35.0 0.079 12.6 1.3 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pkinase PF00069.20 EFW99083.1 - 6.3e-59 199.2 0.1 7.3e-59 199.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99083.1 - 1.4e-18 66.8 0.0 2e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFW99083.1 - 2e-06 27.7 0.0 0.00013 21.8 0.1 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFW99083.1 - 0.01 14.9 0.1 0.019 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFW99083.1 - 0.017 14.1 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like YrbL-PhoP_reg PF10707.4 EFW99083.1 - 0.021 14.1 0.3 0.31 10.3 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Pantoate_ligase PF02569.10 EFW99084.1 - 1.7e-81 273.0 0.0 3.9e-81 271.9 0.0 1.6 1 1 0 1 1 1 1 Pantoate-beta-alanine ligase ATP-sulfurylase PF01747.12 EFW99084.1 - 0.029 13.6 0.6 0.052 12.8 0.1 1.6 2 0 0 2 2 2 0 ATP-sulfurylase DUF2427 PF10348.4 EFW99085.1 - 0.38 10.3 7.4 0.76 9.3 4.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) AA_permease_C PF13906.1 EFW99085.1 - 5.7 6.8 8.1 0.12 12.2 0.3 2.2 3 0 0 3 3 3 0 C-terminus of AA_permease CsbD PF05532.7 EFW99086.1 - 7.2e-20 70.4 17.7 1.6e-10 40.4 1.2 3.1 2 1 1 3 3 3 3 CsbD-like Pentaxin PF00354.12 EFW99086.1 - 0.14 11.5 0.2 0.19 11.1 0.2 1.2 1 0 0 1 1 1 0 Pentaxin family Peptidase_A4 PF01828.12 EFW99087.1 - 1.2e-81 272.8 8.4 1.4e-81 272.5 5.9 1.1 1 0 0 1 1 1 1 Peptidase A4 family CCT_2 PF09425.5 EFW99087.1 - 0.19 11.3 0.3 0.28 10.7 0.2 1.3 1 0 0 1 1 1 0 Divergent CCT motif HSDR_N_2 PF13588.1 EFW99088.1 - 7.6e-05 22.4 0.0 0.21 11.3 0.0 2.4 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase PF00069.20 EFW99088.1 - 0.0011 18.1 0.0 0.0023 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 EFW99088.1 - 0.0027 16.8 0.0 0.0066 15.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFW99088.1 - 0.041 13.6 1.0 1.8 8.2 0.3 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family ThiF PF00899.16 EFW99089.1 - 1.9e-10 40.6 0.0 1.3e-06 28.2 0.3 2.3 1 1 1 2 2 2 2 ThiF family Pkinase PF00069.20 EFW99090.1 - 1.3e-35 122.7 0.0 1.7e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99090.1 - 2.4e-14 53.0 0.0 3.2e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFW99090.1 - 0.017 14.8 0.0 0.53 9.9 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pyrid_oxidase_2 PF13883.1 EFW99091.1 - 1e-45 155.5 0.0 1.3e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase UQ_con PF00179.21 EFW99092.1 - 9.1e-50 167.7 0.0 1.1e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFW99092.1 - 9.5e-07 28.6 0.0 1.3e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFW99092.1 - 0.00059 19.7 0.1 0.00084 19.2 0.1 1.4 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 EFW99092.1 - 0.0029 17.2 0.0 0.0039 16.8 0.0 1.3 1 0 0 1 1 1 1 UEV domain L51_S25_CI-B8 PF05047.11 EFW99093.1 - 5.5e-11 42.0 0.0 7e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CH PF00307.26 EFW99094.1 - 1.1e-62 208.8 0.0 6.6e-16 58.2 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.1 EFW99094.1 - 1.6e-06 28.1 0.8 2.8e-05 24.1 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 EFW99094.1 - 8.7e-05 21.5 0.8 1 8.8 0.2 3.6 3 0 0 3 3 3 2 EF hand CAMSAP_CH PF11971.3 EFW99094.1 - 0.022 14.4 0.0 31 4.2 0.0 3.5 3 0 0 3 3 3 0 CAMSAP CH domain Rep_4 PF05797.6 EFW99094.1 - 0.13 10.9 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) EF-hand_6 PF13405.1 EFW99094.1 - 0.38 10.7 4.0 0.96 9.5 0.1 3.2 4 0 0 4 4 4 0 EF-hand domain Aldedh PF00171.17 EFW99095.1 - 2.5e-136 454.6 0.0 3e-136 454.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EFW99095.1 - 3.7e-05 22.6 0.1 8.7e-05 21.4 0.0 1.5 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Malate_synthase PF01274.17 EFW99097.1 - 6.4e-235 780.0 0.0 7.3e-235 779.9 0.0 1.0 1 0 0 1 1 1 1 Malate synthase PQ-loop PF04193.9 EFW99098.1 - 1e-24 85.8 2.5 1.5e-13 50.0 0.1 2.4 2 0 0 2 2 2 2 PQ loop repeat eIF-6 PF01912.13 EFW99099.1 - 7.2e-79 263.4 0.6 1e-78 262.9 0.4 1.2 1 0 0 1 1 1 1 eIF-6 family DUF2201_N PF13203.1 EFW99099.1 - 2.4 7.2 8.5 5.8 5.9 3.5 2.3 1 1 1 2 2 2 0 Putative metallopeptidase domain Sigma70_ner PF04546.8 EFW99099.1 - 4.2 6.9 6.7 10 5.6 4.7 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.7 EFW99099.1 - 6.7 4.4 14.2 13 3.5 9.9 1.3 1 0 0 1 1 1 0 Nop14-like family Pkinase PF00069.20 EFW99101.1 - 2.4e-73 246.5 0.0 4e-73 245.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99101.1 - 1.9e-37 128.7 0.2 9.2e-35 119.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFW99101.1 - 2.6e-09 36.4 0.0 4.4e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFW99101.1 - 0.0017 18.1 0.0 0.0079 15.9 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFW99101.1 - 0.002 17.2 1.2 0.006 15.6 0.0 2.3 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFW99101.1 - 0.013 15.0 0.3 0.013 15.0 0.2 2.2 3 0 0 3 3 3 0 Choline/ethanolamine kinase Zn_clus PF00172.13 EFW99102.1 - 9.2e-08 31.8 9.2 1.5e-07 31.1 6.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFW99102.1 - 1.7e-06 27.1 0.1 2.7e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Metallophos PF00149.23 EFW99103.1 - 2.4e-11 43.3 1.5 4.2e-11 42.6 1.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase OPT PF03169.10 EFW99104.1 - 4.6e-188 626.5 53.8 5.2e-188 626.3 37.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DnaJ PF00226.26 EFW99105.1 - 3e-05 23.6 0.0 6.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DUF3395 PF11875.3 EFW99105.1 - 0.0025 17.4 0.0 0.0025 17.4 0.0 2.4 1 1 0 2 2 2 1 Domain of unknown function (DUF3395) DUF624 PF04854.9 EFW99105.1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF624 CDC45 PF02724.9 EFW99105.1 - 4.5 5.1 24.2 0.69 7.8 2.1 2.9 3 0 0 3 3 3 0 CDC45-like protein AMP-binding PF00501.23 EFW99106.1 - 1e-68 231.7 0.0 2.7e-66 223.6 0.0 2.2 1 1 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.21 EFW99106.1 - 1.7e-61 207.9 0.7 4e-61 206.7 0.2 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFW99106.1 - 9e-14 51.3 0.0 2.4e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFW99106.1 - 7.1e-05 22.9 0.0 0.00027 21.1 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 EFW99106.1 - 0.00058 18.9 0.2 0.001 18.1 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Pkinase PF00069.20 EFW99109.1 - 3.8e-58 196.6 0.0 5.9e-58 196.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99109.1 - 1.4e-35 122.6 0.0 2.5e-25 89.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFW99109.1 - 0.00029 19.8 0.0 0.00082 18.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like NCA2 PF08637.5 EFW99109.1 - 0.0032 16.4 0.1 0.053 12.4 0.0 2.2 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 APH PF01636.18 EFW99109.1 - 0.097 12.3 0.0 0.097 12.3 0.0 3.5 2 2 1 3 3 3 0 Phosphotransferase enzyme family APG6 PF04111.7 EFW99110.1 - 9.7e-126 419.0 0.0 1.1e-125 418.8 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Apg6 Rpr2 PF04032.11 EFW99110.1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF3142 PF11340.3 EFW99110.1 - 0.15 11.6 0.9 0.72 9.4 0.1 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3142) bZIP_2 PF07716.10 EFW99110.1 - 0.41 10.5 10.6 0.1 12.4 5.0 1.8 2 0 0 2 2 2 0 Basic region leucine zipper IncA PF04156.9 EFW99110.1 - 1 8.9 11.4 1.6 8.2 7.9 1.4 1 0 0 1 1 1 0 IncA protein V_ATPase_I PF01496.14 EFW99110.1 - 1.8 6.3 6.3 2.4 5.8 4.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lge1 PF11488.3 EFW99110.1 - 6.4 7.0 7.5 36 4.6 5.2 2.2 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF4337 PF14235.1 EFW99110.1 - 6.6 6.5 10.9 13 5.6 7.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ssu72 PF04722.8 EFW99111.1 - 1.9e-85 285.1 0.0 2.2e-85 284.9 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein HECT PF00632.20 EFW99112.1 - 3e-90 302.5 0.0 4.2e-90 302.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 EFW99112.1 - 3.1e-32 110.0 21.8 2.7e-11 43.1 3.4 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.25 EFW99112.1 - 2.5e-17 62.4 0.1 6.4e-17 61.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain Dynamin_N PF00350.18 EFW99113.1 - 2.2e-15 56.9 0.0 6.3e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 Dynamin family ABC_tran PF00005.22 EFW99113.1 - 5.5e-05 23.4 0.0 0.0018 18.6 0.0 2.7 2 0 0 2 2 2 1 ABC transporter MMR_HSR1 PF01926.18 EFW99113.1 - 7.8e-05 22.6 0.0 0.0035 17.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 EFW99113.1 - 0.0031 16.6 0.0 0.058 12.4 0.0 2.9 4 0 0 4 4 4 1 AIG1 family AAA_22 PF13401.1 EFW99113.1 - 0.013 15.6 0.3 4.6 7.3 0.0 4.3 4 1 1 5 5 5 0 AAA domain AAA_17 PF13207.1 EFW99113.1 - 0.016 15.9 0.0 0.12 13.1 0.0 2.6 3 0 0 3 3 1 0 AAA domain IIGP PF05049.8 EFW99113.1 - 0.028 13.2 0.4 0.89 8.3 0.0 2.9 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) DUF258 PF03193.11 EFW99113.1 - 0.032 13.4 0.0 0.22 10.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SMC_N PF02463.14 EFW99113.1 - 0.068 12.3 0.0 0.19 10.9 0.0 1.7 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Miro PF08477.8 EFW99113.1 - 0.079 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 EFW99113.1 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EFW99113.1 - 0.76 10.0 2.6 0.7 10.1 0.0 2.1 3 0 0 3 3 2 0 AAA domain APG6 PF04111.7 EFW99113.1 - 0.85 8.6 7.7 2.6 7.0 0.1 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 Ank_2 PF12796.2 EFW99114.1 - 1.1e-75 249.9 37.8 3e-17 62.7 0.6 5.7 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFW99114.1 - 9.3e-45 149.6 18.3 1.6e-07 31.3 0.3 9.4 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.25 EFW99114.1 - 1.2e-43 144.7 23.1 4.4e-06 26.2 0.1 10.9 11 0 0 11 11 11 9 Ankyrin repeat Ank_4 PF13637.1 EFW99114.1 - 1.2e-41 140.3 10.5 2.8e-08 34.0 0.1 7.9 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99114.1 - 7e-39 127.9 10.6 2.6e-05 24.0 0.0 10.9 10 0 0 10 10 10 9 Ankyrin repeat DUF2450 PF10475.4 EFW99114.1 - 0.44 9.3 2.3 11 4.8 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function N-terminal domain (DUF2450) vATP-synt_E PF01991.13 EFW99115.1 - 1e-55 188.1 2.6 1.2e-55 187.9 1.8 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Sedlin_N PF04628.8 EFW99116.1 - 1.2e-15 57.5 0.0 1.4e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region CDC50 PF03381.10 EFW99117.1 - 4.1e-98 327.9 0.0 5.2e-98 327.6 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family RdRP PF05183.7 EFW99118.1 - 2.9e-175 584.3 0.0 3.9e-175 583.8 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase FAD-oxidase_C PF02913.14 EFW99118.1 - 2.5e-54 184.2 0.6 5e-54 183.2 0.4 1.5 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EFW99118.1 - 1.5e-33 115.2 0.0 3.1e-33 114.2 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain LuxQ-periplasm PF09308.5 EFW99118.1 - 0.72 9.1 0.0 1.3 8.2 0.0 1.3 1 0 0 1 1 1 0 LuxQ, periplasmic WD40 PF00400.27 EFW99120.1 - 3.2e-24 83.8 16.4 5.3e-08 32.4 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 EFW99120.1 - 0.0098 14.2 1.7 3.8 5.7 0.0 3.8 3 1 1 4 4 4 1 Cytochrome D1 heme domain PQQ_3 PF13570.1 EFW99120.1 - 0.12 12.6 2.4 12 6.3 0.1 3.5 4 0 0 4 4 4 0 PQQ-like domain PD40 PF07676.7 EFW99120.1 - 0.14 11.8 2.0 0.35 10.5 0.1 2.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat MBOAT PF03062.14 EFW99121.1 - 1.6e-35 122.7 25.6 1.6e-35 122.7 17.7 2.8 2 2 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EFW99121.1 - 0.00025 21.0 5.7 0.00025 21.0 4.0 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Nic96 PF04097.9 EFW99121.1 - 0.24 9.4 0.0 0.37 8.8 0.0 1.1 1 0 0 1 1 1 0 Nup93/Nic96 SASP PF00269.15 EFW99121.1 - 0.42 10.4 3.5 44 4.0 0.0 3.4 3 0 0 3 3 3 0 Small, acid-soluble spore proteins, alpha/beta type Lipoprotein_3 PF00938.12 EFW99122.1 - 0.025 14.3 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein MFS_1 PF07690.11 EFW99123.1 - 3e-18 65.6 35.3 9.4e-18 64.0 22.5 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily CLTH PF10607.4 EFW99124.1 - 1.6e-28 99.2 0.0 2.6e-28 98.5 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain adh_short PF00106.20 EFW99125.1 - 5e-28 98.1 9.3 3.2e-27 95.4 4.5 2.5 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW99125.1 - 5.5e-15 55.7 1.6 4.5e-13 49.5 1.1 2.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFW99125.1 - 2.7e-14 53.2 4.2 3.2e-12 46.4 2.9 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFW99125.1 - 0.00082 18.8 0.5 0.0025 17.2 0.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 EFW99125.1 - 0.025 13.7 0.0 0.037 13.1 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.1 EFW99125.1 - 0.031 14.2 1.0 0.06 13.3 0.7 1.5 1 1 0 1 1 1 0 NADH(P)-binding 2-Hacid_dh_C PF02826.14 EFW99125.1 - 0.089 11.9 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NapE PF06796.6 EFW99126.1 - 0.21 10.8 0.3 2.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE UMP1 PF05348.6 EFW99127.1 - 2e-18 66.6 0.1 5.2e-18 65.2 0.0 1.7 1 1 0 1 1 1 1 Proteasome maturation factor UMP1 U3_snoRNA_assoc PF08297.6 EFW99128.1 - 3.1e-06 27.3 0.2 3.1e-06 27.3 0.1 2.7 2 1 0 2 2 2 1 U3 snoRNA associated Spt5_N PF11942.3 EFW99128.1 - 0.46 11.1 22.3 15 6.2 0.0 2.6 2 1 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF572 PF04502.8 EFW99128.1 - 0.78 8.8 17.7 1 8.4 12.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) MRP-S31 PF15433.1 EFW99128.1 - 2.6 7.3 9.4 3.3 7.0 6.5 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Hydrolase_like2 PF13246.1 EFW99129.1 - 9.1e-13 47.9 0.1 8.8e-12 44.8 0.0 2.4 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 EFW99129.1 - 7.5e-12 44.7 0.0 2.8e-11 42.9 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 EFW99129.1 - 1.1e-11 45.3 0.0 3.4e-11 43.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFW99129.1 - 1.3e-10 42.0 2.6 1.5e-06 28.7 0.6 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFW99129.1 - 0.016 14.8 0.5 0.038 13.5 0.4 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PBP1_TM PF14812.1 EFW99129.1 - 0.53 10.6 5.2 2.9 8.2 3.6 2.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aminotran_3 PF00202.16 EFW99130.1 - 5.4e-98 327.9 0.0 7.1e-98 327.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III RasGAP_C PF03836.10 EFW99132.1 - 1.1e-47 161.2 3.0 3.4e-47 159.6 2.1 1.9 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.14 EFW99132.1 - 3.9e-43 147.4 0.0 1e-42 146.0 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase IQ PF00612.22 EFW99132.1 - 1.4e-15 55.3 52.2 0.066 12.8 0.3 14.2 16 0 0 16 16 16 9 IQ calmodulin-binding motif CH PF00307.26 EFW99132.1 - 7.2e-08 32.4 0.0 2.4e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain TPR_4 PF07721.9 EFW99134.1 - 0.0043 17.3 1.6 0.0043 17.3 1.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TauD PF02668.11 EFW99135.1 - 3.1e-39 135.1 0.4 9.8e-39 133.5 0.3 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PPR_2 PF13041.1 EFW99136.1 - 6.4e-32 109.3 1.0 2.1e-11 43.6 0.1 5.7 4 2 2 6 6 6 4 PPR repeat family PPR_1 PF12854.2 EFW99136.1 - 2.8e-23 81.0 0.7 7.9e-10 38.0 0.0 6.1 7 0 0 7 7 7 4 PPR repeat PPR PF01535.15 EFW99136.1 - 7.5e-15 53.7 6.2 0.00024 20.8 0.0 6.2 6 0 0 6 6 6 3 PPR repeat PPR_3 PF13812.1 EFW99136.1 - 1.8e-11 43.3 1.5 0.0041 17.3 0.0 5.5 5 0 0 5 5 5 3 Pentatricopeptide repeat domain RNase_PH PF01138.16 EFW99137.1 - 9.2e-20 71.2 0.0 7.5e-19 68.3 0.0 2.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 GDI PF00996.13 EFW99138.1 - 4.7e-36 124.0 0.0 2e-35 121.9 0.0 1.9 2 1 0 2 2 2 1 GDP dissociation inhibitor F_bP_aldolase PF01116.15 EFW99139.1 - 3.5e-97 324.9 0.0 4e-97 324.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Torsin PF06309.6 EFW99139.1 - 0.11 12.4 0.1 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Torsin Methyltransf_11 PF08241.7 EFW99140.1 - 8e-15 55.1 0.0 1.7e-14 54.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99140.1 - 4.6e-12 46.5 0.0 7.1e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW99140.1 - 7.3e-12 45.5 0.0 2e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFW99140.1 - 2.4e-10 40.3 0.0 3.4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW99140.1 - 1.2e-09 37.9 0.0 1.4e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW99140.1 - 3.2e-08 33.5 0.1 6.1e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99140.1 - 3.6e-07 30.5 0.0 6.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFW99140.1 - 0.0018 17.3 0.0 0.0025 16.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 EFW99140.1 - 0.003 16.9 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain UPF0146 PF03686.8 EFW99140.1 - 0.0054 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0146) MetW PF07021.7 EFW99140.1 - 0.089 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RrnaAD PF00398.15 EFW99140.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase ABC_tran PF00005.22 EFW99141.1 - 3.7e-42 143.8 0.0 3.5e-30 105.1 0.0 3.3 2 1 1 3 3 3 2 ABC transporter ABC_membrane PF00664.18 EFW99141.1 - 1.6e-30 106.4 25.1 1.7e-21 76.8 7.9 3.3 4 0 0 4 4 4 2 ABC transporter transmembrane region SMC_N PF02463.14 EFW99141.1 - 1.7e-08 33.9 0.5 0.00033 19.9 0.1 3.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFW99141.1 - 1.3e-06 28.5 0.9 0.0025 17.8 0.2 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFW99141.1 - 2.1e-05 23.9 0.7 0.067 12.7 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 EFW99141.1 - 2.3e-05 23.9 0.0 0.03 13.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 EFW99141.1 - 0.00014 22.2 0.2 0.0096 16.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 EFW99141.1 - 0.00047 19.1 0.0 0.028 13.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.12 EFW99141.1 - 0.0014 18.4 2.0 0.21 11.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_22 PF13401.1 EFW99141.1 - 0.002 18.2 0.1 6.4 6.9 0.0 3.3 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EFW99141.1 - 0.002 18.0 0.1 0.35 10.8 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFW99141.1 - 0.0024 17.0 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_21 PF13304.1 EFW99141.1 - 0.0026 17.7 0.8 3.4 7.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_10 PF12846.2 EFW99141.1 - 0.0088 15.5 0.5 3.5 6.9 0.0 2.7 2 1 1 3 3 3 1 AAA-like domain Miro PF08477.8 EFW99141.1 - 0.021 15.3 0.3 4.3 7.8 0.1 2.6 2 0 0 2 2 2 0 Miro-like protein Zeta_toxin PF06414.7 EFW99141.1 - 0.036 13.1 0.5 4.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.4 EFW99141.1 - 0.057 12.3 0.1 1.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 EFW99141.1 - 0.063 12.9 0.0 0.7 9.5 0.0 2.6 2 0 0 2 2 2 0 NACHT domain ArgK PF03308.11 EFW99141.1 - 0.079 11.7 0.1 0.17 10.6 0.0 1.5 2 0 0 2 2 2 0 ArgK protein AAA_17 PF13207.1 EFW99141.1 - 0.086 13.6 0.0 12 6.7 0.0 3.0 2 0 0 2 2 2 0 AAA domain SprT-like PF10263.4 EFW99142.1 - 9e-12 44.9 0.0 1.3e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 SprT-like family Adaptin_N PF01602.15 EFW99144.1 - 5.5e-130 434.1 9.7 6.8e-130 433.8 6.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EFW99144.1 - 1.6e-17 63.9 1.3 4.2e-17 62.5 0.0 2.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFW99144.1 - 2e-14 53.6 6.5 3.9e-09 36.6 0.3 4.5 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.17 EFW99144.1 - 1.6e-08 33.9 4.8 0.0021 17.9 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 EFW99144.1 - 9.2e-05 22.8 6.3 0.13 12.7 0.1 5.6 5 1 1 6 6 6 1 HEAT-like repeat CLASP_N PF12348.3 EFW99144.1 - 0.00015 21.2 1.9 0.13 11.6 0.0 3.3 3 0 0 3 3 3 2 CLASP N terminal Atx10homo_assoc PF09759.4 EFW99144.1 - 0.0003 20.4 0.0 0.32 10.7 0.0 3.9 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.18 EFW99144.1 - 0.013 15.3 1.4 2.5 8.0 0.0 4.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF4042 PF13251.1 EFW99144.1 - 0.017 14.6 0.1 1.8 7.9 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) RRP7 PF12923.2 EFW99145.1 - 2.4e-35 121.3 3.0 2.4e-35 121.3 2.1 1.9 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) FERM_M PF00373.13 EFW99145.1 - 0.087 13.0 0.4 0.21 11.7 0.3 1.6 1 1 0 1 1 1 0 FERM central domain DUF1068 PF06364.7 EFW99145.1 - 2.1 7.8 6.3 0.21 11.1 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) SMC_N PF02463.14 EFW99146.1 - 9.3e-25 87.1 0.1 1.5e-24 86.5 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFW99146.1 - 3.9e-11 43.6 20.9 3.9e-11 43.6 14.5 5.3 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.1 EFW99146.1 - 2e-07 31.3 0.2 0.00065 19.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain Reo_sigmaC PF04582.7 EFW99146.1 - 0.0036 16.5 4.6 0.18 10.9 0.0 3.4 2 1 1 3 3 3 2 Reovirus sigma C capsid protein AAA_29 PF13555.1 EFW99146.1 - 0.004 16.6 0.0 0.0085 15.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EFW99146.1 - 0.013 14.8 0.0 0.086 12.2 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.1 EFW99146.1 - 0.058 12.4 8.8 0.43 9.5 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.22 EFW99146.1 - 0.29 11.4 0.0 0.29 11.4 0.0 5.5 3 2 0 3 3 3 0 ABC transporter AAA_13 PF13166.1 EFW99146.1 - 1.7 6.9 0.0 1.7 6.9 0.0 4.2 3 2 1 4 4 4 0 AAA domain MOZ_SAS PF01853.13 EFW99147.1 - 8.3e-84 279.5 0.1 1.2e-83 279.0 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 EFW99147.1 - 4.3e-16 58.3 0.0 1e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.19 EFW99147.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFW99147.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DDHD PF02862.12 EFW99148.1 - 4.5e-71 239.2 6.0 2.7e-70 236.6 0.0 3.2 2 1 0 2 2 2 1 DDHD domain DUF2404 PF10296.4 EFW99148.1 - 0.001 19.1 0.0 0.0025 17.9 0.0 1.6 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Dabb PF07876.7 EFW99149.1 - 3e-24 85.2 0.0 3.4e-24 85.1 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Pex24p PF06398.6 EFW99151.1 - 1e-85 287.6 0.0 1.3e-85 287.4 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Lyase_1 PF00206.15 EFW99152.1 - 3.8e-111 371.2 0.0 5.3e-111 370.7 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 EFW99152.1 - 1.8e-22 79.1 0.0 3.9e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus CENP-O PF09496.5 EFW99153.1 - 3.9e-20 71.8 0.0 9.5e-20 70.6 0.0 1.7 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component DUF159 PF02586.9 EFW99154.1 - 3.8e-44 150.7 0.0 6.1e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 NAD_binding_1 PF00175.16 EFW99155.1 - 2.6e-28 98.7 0.0 4.1e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFW99155.1 - 4.2e-21 74.9 0.0 7.8e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EFW99155.1 - 5.8e-09 36.0 0.0 4.4e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 EFW99155.1 - 0.00071 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain Syntaxin-18_N PF10496.4 EFW99156.1 - 3.8e-11 42.6 0.0 9.6e-11 41.3 0.0 1.7 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.14 EFW99156.1 - 0.0087 15.7 0.9 0.024 14.3 0.6 1.7 1 0 0 1 1 1 1 SNARE domain UPF0086 PF01868.11 EFW99157.1 - 9.3e-24 82.9 0.1 1.9e-23 81.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Gastrin PF00918.12 EFW99157.1 - 0.33 11.7 3.4 0.79 10.5 2.4 1.6 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Fungal_trans PF04082.13 EFW99158.1 - 2e-07 30.1 0.0 3.7e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW99158.1 - 8.1e-06 25.6 11.0 2e-05 24.4 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.24 EFW99159.1 - 7e-38 129.7 0.0 1.1e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99159.1 - 2e-24 85.2 0.0 6.2e-23 80.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW99159.1 - 2.2e-06 27.6 0.0 5.5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sas10_Utp3 PF04000.10 EFW99161.1 - 2.8e-13 49.8 0.0 4.9e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF1192 PF06698.6 EFW99161.1 - 0.014 15.1 0.9 0.22 11.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) LicD PF04991.8 EFW99162.1 - 3.4e-37 128.5 3.2 1.2e-35 123.4 2.2 2.1 1 1 0 1 1 1 1 LicD family F-box PF00646.28 EFW99163.1 - 0.0051 16.4 0.6 0.0051 16.4 0.4 2.4 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.2 EFW99163.1 - 0.027 14.2 0.9 0.099 12.3 0.6 2.0 1 0 0 1 1 1 0 F-box-like MCM PF00493.18 EFW99164.1 - 1.6e-91 306.5 2.7 1.5e-50 171.8 0.1 2.2 1 1 1 2 2 2 2 MCM2/3/5 family MCM_N PF14551.1 EFW99164.1 - 1.7e-14 54.3 0.2 8.4e-14 52.1 0.0 2.2 2 1 0 2 2 2 1 MCM N-terminal domain DEAD PF00270.24 EFW99167.1 - 9.8e-28 96.7 0.0 4.1e-17 62.1 0.0 3.0 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99167.1 - 1.8e-23 82.1 0.0 4.2e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SecA_DEAD PF07517.9 EFW99167.1 - 0.051 12.8 0.0 4.4 6.5 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain RNase_H PF00075.19 EFW99168.1 - 6.6e-06 26.4 0.0 8.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 RNase H Cyclin PF08613.6 EFW99171.1 - 8.6e-13 48.9 0.0 1.6e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EFW99171.1 - 0.012 15.2 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain Methyltransf_23 PF13489.1 EFW99172.1 - 7e-20 71.3 0.1 1.9e-19 69.9 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFW99172.1 - 9.3e-17 61.3 0.0 8.1e-15 55.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW99172.1 - 1e-11 44.6 0.0 2.5e-10 40.1 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99172.1 - 2e-11 44.4 0.0 1e-09 38.9 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99172.1 - 1.7e-09 38.0 0.1 5e-08 33.3 0.0 2.9 2 2 1 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW99172.1 - 3.7e-08 33.6 0.0 1.1e-07 32.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFW99172.1 - 1.5e-05 24.2 0.0 0.00021 20.4 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFW99172.1 - 2.5e-05 24.2 0.0 0.00023 21.1 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 EFW99172.1 - 0.00016 21.7 0.0 0.002 18.1 0.0 2.1 1 1 1 2 2 2 1 FtsJ-like methyltransferase MTS PF05175.9 EFW99172.1 - 0.00044 19.6 0.0 0.0012 18.2 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.12 EFW99172.1 - 0.0016 17.5 0.0 0.0034 16.4 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.13 EFW99172.1 - 0.0056 15.9 0.0 0.0073 15.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PrmA PF06325.8 EFW99172.1 - 0.02 14.0 0.0 0.029 13.4 0.0 1.3 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_PK PF05891.7 EFW99172.1 - 0.026 13.8 0.6 0.057 12.7 0.1 1.7 2 1 0 2 2 2 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.4 EFW99172.1 - 0.035 13.5 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase RRM_1 PF00076.17 EFW99173.1 - 8.6e-17 60.5 0.0 1.6e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99173.1 - 8.3e-16 57.7 0.0 1.6e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99173.1 - 4.6e-06 26.3 0.0 7.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Packaging_FI PF14000.1 EFW99173.1 - 0.0093 16.1 1.2 0.013 15.6 0.8 1.3 1 0 0 1 1 1 1 DNA packaging protein FI WD40_alt PF14077.1 EFW99173.1 - 0.056 13.0 0.8 0.1 12.2 0.5 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif Nup35_RRM_2 PF14605.1 EFW99173.1 - 0.097 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif IncA PF04156.9 EFW99173.1 - 0.28 10.7 4.1 0.37 10.3 2.8 1.1 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 EFW99173.1 - 1.4 7.9 4.2 1.6 7.7 2.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4337 PF14235.1 EFW99173.1 - 2.2 8.0 4.0 3 7.6 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Tbf5 PF06331.7 EFW99174.1 - 6e-27 93.2 2.2 6.7e-27 93.0 1.5 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 RGS PF00615.14 EFW99175.1 - 2.2e-12 47.1 0.0 1.4e-10 41.2 0.0 2.3 1 1 0 1 1 1 1 Regulator of G protein signaling domain Pkinase PF00069.20 EFW99176.1 - 1.1e-75 254.1 0.0 1.5e-75 253.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99176.1 - 3.3e-37 127.9 0.0 4.8e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 EFW99176.1 - 3.4e-14 52.7 0.2 1.2e-13 51.0 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 EFW99176.1 - 6.7e-06 25.2 0.0 1.9e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 EFW99176.1 - 0.0032 16.8 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 EFW99176.1 - 0.014 14.0 0.0 0.022 13.3 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC APH PF01636.18 EFW99176.1 - 0.028 14.1 0.1 0.21 11.2 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2841 PF11001.3 EFW99177.1 - 4.5e-37 126.7 4.1 6.9e-37 126.1 2.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Nucleoporin_C PF03177.9 EFW99179.1 - 6.5e-81 272.6 0.7 8.4e-81 272.2 0.5 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EFW99179.1 - 1.1e-70 238.5 0.0 1.5e-70 238.1 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Acetyltransf_1 PF00583.19 EFW99180.1 - 1.1e-09 38.1 0.0 1.9e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFW99180.1 - 4.5e-08 33.1 0.0 6.7e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Glyoxalase PF00903.20 EFW99180.1 - 0.0012 18.8 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Acetyltransf_10 PF13673.1 EFW99180.1 - 0.0082 16.2 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFW99180.1 - 0.027 14.3 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.11 EFW99181.1 - 1.7e-51 175.0 61.5 5.4e-37 127.3 24.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HLH PF00010.21 EFW99182.1 - 1.6e-10 40.4 0.0 5.4e-10 38.8 0.0 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DivIC PF04977.10 EFW99182.1 - 0.0039 16.6 1.1 0.0072 15.7 0.8 1.4 1 0 0 1 1 1 1 Septum formation initiator Myb_DNA-bind_6 PF13921.1 EFW99183.1 - 4.5e-12 45.8 0.1 1.1e-05 25.3 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFW99183.1 - 1.1e-11 44.5 0.4 3.3e-06 27.0 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Hexapep PF00132.19 EFW99184.1 - 5.8e-12 44.5 18.3 5.9e-07 28.7 5.7 3.3 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFW99184.1 - 5e-11 41.9 16.4 3.8e-06 26.3 5.2 2.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.3 EFW99184.1 - 5.7e-10 39.0 0.0 1.4e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Zn_clus PF00172.13 EFW99184.1 - 8.8e-10 38.3 8.7 1.6e-09 37.4 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nop53 PF07767.6 EFW99185.1 - 2.3e-96 323.1 26.6 2.8e-96 322.8 18.4 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Fungal_trans PF04082.13 EFW99187.1 - 1.9e-20 72.8 0.0 2.9e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW99187.1 - 1.5e-05 24.7 9.8 1.5e-05 24.7 6.8 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tyrosinase PF00264.15 EFW99188.1 - 1.2e-46 159.7 3.9 2.4e-46 158.6 2.7 1.6 1 0 0 1 1 1 1 Common central domain of tyrosinase DAO PF01266.19 EFW99189.1 - 1.8e-46 158.6 5.3 3e-46 157.9 3.7 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFW99189.1 - 6.2e-06 25.3 2.5 1.4e-05 24.1 1.7 1.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 EFW99189.1 - 4.6e-05 23.3 0.2 0.00016 21.5 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EFW99189.1 - 0.0021 17.2 0.1 0.0045 16.1 0.0 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 EFW99189.1 - 0.0035 16.4 0.2 0.0061 15.6 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFW99189.1 - 0.075 12.8 0.2 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF3328 PF11807.3 EFW99190.1 - 1.8e-28 99.7 0.1 2.3e-28 99.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Myb_DNA-bind_3 PF12776.2 EFW99192.1 - 6.9e-18 65.0 0.2 1.2e-17 64.2 0.2 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF883 PF05957.8 EFW99194.1 - 0.023 15.0 6.8 0.049 14.0 4.7 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Chorion_S16 PF05836.7 EFW99194.1 - 7.2 6.5 7.9 4.9 7.0 2.1 2.3 2 0 0 2 2 2 0 Chorion protein S16 Nnf1 PF03980.9 EFW99195.1 - 1.9e-19 69.6 0.2 1.3e-18 67.0 0.0 2.2 2 0 0 2 2 2 1 Nnf1 PalH PF08733.5 EFW99196.1 - 0.18 10.5 1.9 0.26 10.0 1.3 1.3 1 0 0 1 1 1 0 PalH/RIM21 DsbD_2 PF13386.1 EFW99196.1 - 0.88 9.2 11.5 1.4 8.6 7.9 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region TauD PF02668.11 EFW99197.1 - 7e-44 150.4 0.0 1e-43 149.8 0.0 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.1 EFW99197.1 - 0.023 15.1 0.1 1.5 9.4 0.0 2.4 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Peptidase_C80 PF11713.3 EFW99197.1 - 0.048 13.4 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase C80 family Ribosomal_L31e PF01198.14 EFW99200.1 - 1.6e-37 126.9 1.2 2.1e-37 126.6 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e DUF4412 PF14371.1 EFW99200.1 - 0.13 12.8 0.0 0.21 12.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4412) IMPDH PF00478.20 EFW99201.1 - 2.3e-131 437.8 1.8 2.8e-131 437.5 1.2 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 EFW99201.1 - 5.8e-17 61.2 0.4 2.3e-08 33.7 0.1 2.4 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 EFW99201.1 - 2.3e-09 36.8 2.8 0.00047 19.3 1.8 2.5 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.13 EFW99201.1 - 3.5e-08 32.6 0.6 1.6e-06 27.2 0.2 2.3 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EFW99201.1 - 0.00021 20.6 2.2 7 5.8 0.1 2.5 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 EFW99201.1 - 0.023 13.7 0.9 0.068 12.2 0.1 1.9 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG cNMP_binding PF00027.24 EFW99202.1 - 6.7e-41 138.0 0.0 3.6e-21 74.7 0.0 2.5 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain RNase_H2_suC PF08615.6 EFW99203.1 - 5.1e-24 84.6 0.0 6.8e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) APH PF01636.18 EFW99204.1 - 1.3e-16 61.1 1.8 1.2e-07 31.7 0.0 3.5 2 1 1 3 3 3 3 Phosphotransferase enzyme family zf-AN1 PF01428.11 EFW99204.1 - 0.00026 20.7 7.0 0.00052 19.8 4.9 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger DUF1253 PF06862.7 EFW99207.1 - 2.7e-152 507.2 0.0 4e-152 506.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DEAD PF00270.24 EFW99207.1 - 0.028 13.8 0.0 0.39 10.1 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase TFIIA PF03153.8 EFW99207.1 - 3.7 7.3 23.9 6.9 6.4 16.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FRG2 PF15315.1 EFW99207.1 - 4 7.3 13.3 8.1 6.3 9.2 1.5 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Herpes_LMP1 PF05297.6 EFW99207.1 - 4.3 6.1 6.9 7.7 5.3 4.8 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Ycf1 PF05758.7 EFW99207.1 - 4.4 4.8 5.1 6.6 4.3 3.5 1.3 1 0 0 1 1 1 0 Ycf1 eIF-5_eIF-2B PF01873.12 EFW99208.1 - 1.2e-44 150.9 0.3 1.8e-44 150.3 0.2 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Lar_restr_allev PF14354.1 EFW99208.1 - 0.062 13.6 0.5 0.3 11.4 0.3 2.3 2 1 0 2 2 2 0 Restriction alleviation protein Lar Arc_trans_TRASH PF08394.5 EFW99208.1 - 0.8 9.9 6.3 1.6 8.9 0.1 2.4 1 1 1 2 2 2 0 Archaeal TRASH domain DUF3807 PF12720.2 EFW99209.1 - 3.5e-07 30.5 6.2 3.6e-05 23.9 0.4 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3807) Oxidored_q6 PF01058.17 EFW99210.1 - 1.4e-22 79.6 0.0 2.2e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Tyrosinase PF00264.15 EFW99211.1 - 3.8e-47 161.3 0.0 5e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase SnoaL PF07366.7 EFW99212.1 - 0.0048 16.4 0.0 0.015 14.8 0.0 1.8 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 EFW99212.1 - 0.075 13.4 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 SnoaL-like domain RNase_P_p30 PF01876.11 EFW99213.1 - 2.7e-37 127.3 0.0 1.3e-36 125.0 0.0 2.0 1 1 0 1 1 1 1 RNase P subunit p30 GFA PF04828.9 EFW99213.1 - 0.0013 18.6 2.0 0.0013 18.6 1.4 3.4 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Plasmodium_HRP PF05403.6 EFW99213.1 - 0.064 12.8 2.3 0.11 12.0 1.6 1.3 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Ctr PF04145.10 EFW99214.1 - 9.9e-30 103.4 0.1 2e-29 102.5 0.0 1.5 1 0 0 1 1 1 1 Ctr copper transporter family RRM_6 PF14259.1 EFW99214.1 - 2.2e-06 27.5 0.0 4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFW99214.1 - 0.00072 19.1 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRI PF08236.6 EFW99215.1 - 3.2e-21 75.0 1.4 6.4e-21 74.0 0.9 1.5 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 EFW99215.1 - 8e-20 71.7 0.2 8e-20 71.7 0.1 3.2 3 2 0 3 3 3 1 SET domain Med26 PF08711.6 EFW99215.1 - 0.015 14.7 1.1 0.07 12.6 0.1 2.4 2 0 0 2 2 2 0 TFIIS helical bundle-like domain WW PF00397.21 EFW99215.1 - 0.14 12.0 2.3 0.15 11.9 0.4 2.0 2 0 0 2 2 2 0 WW domain BAR PF03114.13 EFW99216.1 - 4.9e-61 206.1 9.8 6.6e-61 205.7 6.8 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 EFW99216.1 - 1.1e-13 50.3 0.1 1.1e-13 50.3 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 EFW99216.1 - 2.1e-12 46.3 0.1 5e-12 45.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFW99216.1 - 5.5e-11 41.7 1.2 1.1e-10 40.8 0.0 2.1 3 0 0 3 3 3 1 Variant SH3 domain DUF605 PF04652.11 EFW99216.1 - 0.00067 19.1 2.4 0.00089 18.7 1.6 1.2 1 0 0 1 1 1 1 Vta1 like DUF3287 PF11690.3 EFW99216.1 - 1.8 8.6 5.1 1.6 8.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) MFS_1 PF07690.11 EFW99217.1 - 3.4e-35 121.3 23.4 3.4e-35 121.3 16.2 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFW99217.1 - 6.7e-12 44.7 5.3 9.5e-12 44.2 3.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter Sensor PF13796.1 EFW99217.1 - 0.0015 18.1 7.3 0.0015 18.1 5.0 2.3 1 1 1 2 2 2 1 Putative sensor DUF1049 PF06305.6 EFW99217.1 - 3.8 7.0 7.5 6.7 6.2 0.1 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1049) Ran_BP1 PF00638.13 EFW99218.1 - 9.2e-15 54.7 0.1 3.4e-14 52.9 0.1 1.9 1 1 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.1 EFW99218.1 - 1.1e-10 41.6 152.9 2.7e-05 24.3 22.8 11.2 2 2 8 10 10 10 6 Nucleoporin FG repeat region DUF2431 PF10354.4 EFW99219.1 - 2.7e-50 170.5 0.0 3.3e-50 170.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltransf_26 PF13659.1 EFW99219.1 - 6.4e-06 26.1 0.5 1.2e-05 25.2 0.3 1.5 1 1 0 1 1 1 1 Methyltransferase domain PBP1_TM PF14812.1 EFW99221.1 - 0.95 9.8 5.1 2.5 8.4 3.5 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-CCHC_3 PF13917.1 EFW99222.1 - 1.4e-10 40.7 1.0 2.6e-10 39.8 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF1522 PF07482.6 EFW99223.1 - 0.013 15.6 0.4 0.013 15.6 0.3 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1522) Bundlin PF05307.6 EFW99223.1 - 0.41 10.5 3.9 0.63 9.9 1.9 2.0 1 1 0 1 1 1 0 Bundlin Glyco_hydro_72 PF03198.9 EFW99224.1 - 4.6e-120 400.3 1.1 5.4e-120 400.1 0.8 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 EFW99224.1 - 3.3e-08 33.0 0.7 2.6e-07 30.1 0.5 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4630 PF15443.1 EFW99225.1 - 0.029 14.1 1.4 0.038 13.7 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4630) SR-25 PF10500.4 EFW99225.1 - 2.4 7.5 12.6 4.7 6.6 8.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_L14e PF01929.12 EFW99226.1 - 1.4e-26 92.6 3.6 4.3e-26 91.0 2.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.24 EFW99226.1 - 0.00012 21.6 0.0 0.00035 20.1 0.0 1.8 1 0 0 1 1 1 1 KOW motif Glyco_tran_28_C PF04101.11 EFW99227.1 - 6.2e-14 51.9 0.0 1.8e-13 50.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SRF-TF PF00319.13 EFW99228.1 - 7.4e-24 82.7 0.4 1.1e-23 82.2 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) PH_9 PF15410.1 EFW99229.1 - 1.1e-05 25.5 0.0 2.3e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EFW99229.1 - 0.0011 19.1 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 PH domain Ribosomal_L11_N PF03946.9 EFW99229.1 - 0.11 11.9 0.1 0.33 10.4 0.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain Aminotran_1_2 PF00155.16 EFW99230.1 - 6.5e-84 281.9 0.0 7.4e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Lyase_1 PF00206.15 EFW99231.1 - 3.8e-87 292.3 0.0 5e-87 291.9 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 EFW99231.1 - 7.6e-25 86.7 0.2 1.5e-24 85.8 0.2 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Isy1 PF06246.7 EFW99232.1 - 4.9e-85 285.0 0.0 5.5e-85 284.8 0.0 1.0 1 0 0 1 1 1 1 Isy1-like splicing family DUF310 PF03750.8 EFW99232.1 - 0.16 12.1 0.3 7.3 6.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF310) ABC_membrane PF00664.18 EFW99233.1 - 3.2e-80 269.5 39.7 9.3e-49 166.2 8.1 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFW99233.1 - 1.7e-50 170.8 0.0 3.5e-30 105.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFW99233.1 - 6.4e-11 41.9 0.0 0.00015 21.0 0.0 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFW99233.1 - 4.3e-07 30.1 0.4 0.041 13.8 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFW99233.1 - 1.5e-06 27.6 0.1 0.051 13.0 0.0 3.1 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 EFW99233.1 - 2.1e-05 24.0 0.0 0.03 13.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFW99233.1 - 2.5e-05 24.2 0.1 0.36 10.8 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.1 EFW99233.1 - 5.3e-05 23.3 0.4 0.17 11.8 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.1 EFW99233.1 - 7.1e-05 23.2 0.0 0.0097 16.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFW99233.1 - 0.00014 21.1 0.0 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 EFW99233.1 - 0.0011 19.3 0.2 3.1 8.3 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein RNA_helicase PF00910.17 EFW99233.1 - 0.0028 17.7 0.0 0.17 12.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Dynamin_N PF00350.18 EFW99233.1 - 0.0042 16.9 0.5 0.47 10.2 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.1 EFW99233.1 - 0.0056 16.2 1.2 1.6 8.2 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFW99233.1 - 0.027 14.6 1.6 2.7 8.1 0.0 3.1 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.8 EFW99233.1 - 0.04 12.8 0.1 2.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.13 EFW99233.1 - 0.047 13.1 0.0 3.3 7.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 EFW99233.1 - 0.071 12.5 0.3 4.9 6.6 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.7 EFW99233.1 - 0.14 11.2 0.1 5.1 6.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.1 EFW99233.1 - 0.15 12.9 0.2 6.5 7.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 EFW99233.1 - 1.3 8.7 3.7 1.2 8.8 0.0 2.4 3 0 0 3 3 2 0 Domain of unknown function DUF87 XPC-binding PF09280.6 EFW99234.1 - 1.6e-24 85.0 12.1 3e-24 84.2 8.4 1.5 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.26 EFW99234.1 - 6.7e-20 70.3 4.6 1.5e-09 37.3 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.18 EFW99234.1 - 4.3e-19 67.6 0.4 6.6e-19 67.0 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EFW99234.1 - 4.4e-10 39.1 0.4 8e-10 38.2 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.5 EFW99234.1 - 0.00029 20.3 0.0 0.31 10.6 0.0 2.4 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain DUF2407 PF10302.4 EFW99234.1 - 0.0012 18.9 0.0 0.0026 17.9 0.0 1.6 2 0 0 2 2 1 1 DUF2407 ubiquitin-like domain MCM_N PF14551.1 EFW99234.1 - 0.0032 17.9 0.1 0.0081 16.6 0.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Ubiquitin_2 PF14560.1 EFW99234.1 - 0.0034 17.5 0.1 0.01 16.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 EFW99234.1 - 0.005 16.7 0.1 0.011 15.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like eIF-5a PF01287.15 EFW99234.1 - 0.0068 16.3 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Rap1_C PF11626.3 EFW99234.1 - 0.15 11.9 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Tyrosinase PF00264.15 EFW99235.1 - 5e-39 134.7 6.6 7.7e-39 134.1 4.6 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase SUZ PF12752.2 EFW99236.1 - 4.1e-14 52.8 3.8 4.1e-14 52.8 2.6 2.4 3 0 0 3 3 3 1 SUZ domain R3H PF01424.17 EFW99236.1 - 3.4e-07 29.8 0.0 6.9e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 R3H domain ABC_tran PF00005.22 EFW99237.1 - 2.2e-21 76.5 0.0 4.8e-10 39.8 0.0 3.5 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFW99237.1 - 1.7e-08 34.8 0.0 0.027 14.4 0.0 4.0 4 0 0 4 4 4 2 AAA domain SbcCD_C PF13558.1 EFW99237.1 - 7e-08 32.2 0.0 0.00018 21.3 0.0 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 EFW99237.1 - 4.9e-06 27.3 0.0 0.19 12.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFW99237.1 - 0.00011 21.6 0.1 0.023 14.2 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFW99237.1 - 0.00016 21.6 0.8 0.3 11.0 0.2 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 EFW99237.1 - 0.00038 20.6 0.0 0.35 11.0 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFW99237.1 - 0.00066 19.5 0.0 0.55 10.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 EFW99237.1 - 0.0066 15.8 0.7 1.8 7.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain Miro PF08477.8 EFW99237.1 - 0.0068 16.8 0.0 0.53 10.8 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein AAA_23 PF13476.1 EFW99237.1 - 0.0076 16.5 0.3 0.16 12.2 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EFW99237.1 - 0.0079 15.6 0.0 3.5 6.9 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain ATP_bind_1 PF03029.12 EFW99237.1 - 0.0082 15.7 0.0 4.2 6.8 0.0 2.2 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein AAA PF00004.24 EFW99237.1 - 0.01 16.0 0.0 0.41 10.8 0.0 2.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFW99237.1 - 0.018 14.9 0.0 8.4 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EFW99237.1 - 0.022 14.4 0.1 7.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 EFW99237.1 - 0.032 14.3 0.0 1 9.5 0.0 2.3 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.4 EFW99237.1 - 0.033 13.6 0.0 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 EFW99237.1 - 0.041 13.5 0.0 2.3 7.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.1 EFW99237.1 - 0.05 13.5 0.0 4.7 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EFW99237.1 - 0.061 13.6 0.0 10 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EFW99237.1 - 0.15 11.2 0.0 5.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 cobW PF02492.14 EFW99237.1 - 0.24 10.8 0.0 0.8 9.1 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.5 EFW99237.1 - 0.26 10.4 0.0 17 4.5 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 EFW99237.1 - 0.27 10.7 0.0 4.5 6.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.1 EFW99237.1 - 0.28 9.5 0.1 0.4 9.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain MPC PF03650.8 EFW99238.1 - 1.6e-40 137.7 0.3 2.4e-40 137.2 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) TadE PF07811.7 EFW99238.1 - 0.073 12.9 0.2 0.073 12.9 0.1 2.5 2 0 0 2 2 2 0 TadE-like protein WD40 PF00400.27 EFW99239.1 - 2.1e-21 74.9 3.2 0.00043 20.0 0.0 6.2 5 2 0 5 5 5 5 WD domain, G-beta repeat BCAS2 PF05700.6 EFW99240.1 - 3.9e-38 131.1 1.7 5e-38 130.7 1.2 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Presenilin PF01080.12 EFW99241.1 - 0.41 9.4 2.4 0.48 9.1 1.7 1.1 1 0 0 1 1 1 0 Presenilin Myb_DNA-binding PF00249.26 EFW99242.1 - 4.1e-06 26.7 0.0 8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFW99242.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain tRNA-synt_2 PF00152.15 EFW99243.1 - 8.9e-71 238.3 0.0 1.1e-70 238.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFW99243.1 - 0.06 13.2 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Aminotran_1_2 PF00155.16 EFW99246.1 - 6.9e-19 68.0 0.0 1e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 EFW99246.1 - 0.1 11.1 0.0 0.71 8.3 0.0 1.9 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase SH3_1 PF00018.23 EFW99247.1 - 3.5e-08 32.7 0.0 7.1e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFW99247.1 - 2.3e-07 30.2 0.0 5.2e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFW99247.1 - 0.00016 21.1 0.0 0.00039 19.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Atg14 PF10186.4 EFW99248.1 - 1.5e-73 247.4 0.0 1.8e-73 247.1 0.0 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 ECM11 PF15463.1 EFW99248.1 - 0.21 11.8 6.6 0.4 10.9 4.6 1.5 1 0 0 1 1 1 0 Extracellular mutant protein 11 Mito_carr PF00153.22 EFW99249.1 - 1.4e-61 204.2 3.9 1.3e-25 88.9 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein NB-ARC PF00931.17 EFW99250.1 - 4.5e-22 78.2 0.0 7e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.1 EFW99250.1 - 8.5e-14 51.2 1.3 0.00049 19.9 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFW99250.1 - 3.9e-10 39.2 2.7 0.052 13.2 0.0 4.4 2 1 3 5 5 5 4 TPR repeat AAA_16 PF13191.1 EFW99250.1 - 3.7e-05 23.7 3.9 0.086 12.8 0.1 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 EFW99250.1 - 0.00025 21.1 0.0 0.00088 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain TPR_10 PF13374.1 EFW99250.1 - 0.014 15.2 5.1 37 4.4 0.1 5.5 4 1 1 5 5 5 0 Tetratricopeptide repeat Arch_ATPase PF01637.13 EFW99250.1 - 0.045 13.4 0.0 0.14 11.8 0.0 1.8 1 1 0 1 1 1 0 Archaeal ATPase Apc3 PF12895.2 EFW99250.1 - 0.1 12.7 0.0 2 8.6 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EFW99250.1 - 2.5 8.9 14.5 2.3 9.1 0.1 6.0 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFW99250.1 - 5.1 7.8 10.4 1.6 9.5 0.0 4.2 3 1 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 EFW99251.1 - 5.4e-55 186.3 0.0 1e-54 185.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99251.1 - 6.2e-19 68.0 0.0 1.1e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFW99251.1 - 0.074 12.7 0.6 0.27 10.9 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family SCA7 PF08313.7 EFW99252.1 - 1.3e-34 117.6 0.7 1.3e-34 117.6 0.5 1.9 2 0 0 2 2 2 1 SCA7, zinc-binding domain Nop14 PF04147.7 EFW99252.1 - 0.048 11.5 8.0 0.091 10.6 5.5 1.4 1 0 0 1 1 1 0 Nop14-like family HAD_2 PF13419.1 EFW99255.1 - 2.5e-12 47.3 0.0 2.4e-11 44.1 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFW99255.1 - 4e-05 24.1 0.0 0.00017 22.0 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFW99255.1 - 7.9e-05 22.2 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like PdxJ PF03740.8 EFW99256.1 - 0.17 10.9 0.0 0.22 10.6 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ Aldedh PF00171.17 EFW99257.1 - 6e-71 239.1 0.0 1.2e-70 238.1 0.0 1.4 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_S4e PF00900.15 EFW99258.1 - 2.2e-31 107.3 0.2 4.3e-31 106.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.7 EFW99258.1 - 4.4e-17 61.6 4.0 9.4e-17 60.5 2.8 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.24 EFW99258.1 - 2.3e-05 23.9 2.0 7.4e-05 22.3 0.2 2.8 3 0 0 3 3 3 1 KOW motif S4 PF01479.20 EFW99258.1 - 0.00059 19.2 0.0 0.0011 18.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain MFS_1 PF07690.11 EFW99259.1 - 3e-52 177.5 17.0 3e-52 177.5 11.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFW99259.1 - 1.2e-10 40.5 12.8 1.2e-10 40.5 8.8 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter Pyr_redox_2 PF07992.9 EFW99260.1 - 4.2e-19 69.2 0.0 5.7e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFW99260.1 - 6.2e-12 45.7 0.0 5.6e-10 39.4 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.27 EFW99260.1 - 2.6e-06 26.2 0.1 5.7e-06 25.2 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 EFW99260.1 - 6e-05 22.5 0.4 0.00018 21.0 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 EFW99260.1 - 0.00016 21.7 0.5 0.00043 20.3 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 EFW99260.1 - 0.0018 17.5 0.4 0.0049 16.1 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 EFW99260.1 - 0.078 12.6 0.0 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair RRM_1 PF00076.17 EFW99262.1 - 2.2e-10 39.9 0.0 3.1e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99262.1 - 5e-08 32.8 0.0 7.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99262.1 - 8.3e-08 31.9 0.0 1.2e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFW99262.1 - 0.00029 20.5 0.0 0.00045 19.9 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif F-box PF00646.28 EFW99263.1 - 1.6e-06 27.5 0.4 4e-06 26.3 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFW99263.1 - 0.0022 17.6 1.5 0.0087 15.7 0.2 2.4 2 0 0 2 2 2 1 F-box-like ApbA PF02558.11 EFW99264.1 - 2.3e-24 85.5 0.0 3.5e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 EFW99264.1 - 2.6e-22 79.1 0.0 3.9e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF4336 PF14234.1 EFW99265.1 - 5.8e-16 58.5 0.1 2.9e-11 43.0 0.0 2.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4336) Coatomer_E PF04733.9 EFW99266.1 - 2.2e-56 191.1 8.3 2.5e-56 190.9 5.8 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_15 PF13429.1 EFW99266.1 - 9.1e-07 28.2 8.6 0.00012 21.2 0.6 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFW99266.1 - 2.3e-06 27.8 22.7 0.018 15.3 3.2 3.9 3 2 1 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 EFW99266.1 - 3.8e-05 24.2 18.8 0.0013 19.3 0.7 4.7 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFW99266.1 - 4.3e-05 23.7 23.5 0.00024 21.4 0.8 6.1 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFW99266.1 - 0.00022 20.9 6.1 0.21 11.4 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 EFW99266.1 - 0.00023 20.7 0.4 0.00023 20.7 0.3 3.3 3 1 1 4 4 4 1 TPR repeat TPR_2 PF07719.12 EFW99266.1 - 0.00049 19.7 8.6 0.0041 16.9 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFW99266.1 - 0.0013 18.3 0.0 0.035 13.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 EFW99266.1 - 0.0032 17.5 4.2 0.41 10.8 0.3 3.0 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 EFW99266.1 - 0.0032 17.5 0.8 0.65 10.3 0.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFW99266.1 - 0.0062 16.9 5.0 0.26 11.8 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.3 EFW99266.1 - 0.0097 14.7 4.0 0.71 8.5 0.3 2.3 1 1 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_5 PF12688.2 EFW99266.1 - 0.031 14.2 11.7 0.85 9.6 0.3 3.3 2 1 1 3 3 3 0 Tetratrico peptide repeat TPR_1 PF00515.23 EFW99266.1 - 0.035 13.7 1.3 2.2 8.0 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 EFW99266.1 - 0.35 10.7 6.8 1.8 8.5 0.0 4.6 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFW99266.1 - 0.36 10.7 14.1 0.23 11.4 0.4 4.4 3 2 3 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFW99266.1 - 0.62 10.6 30.9 0.78 10.3 0.9 5.9 6 1 0 6 6 5 0 Tetratricopeptide repeat ADH_N PF08240.7 EFW99267.1 - 2.5e-20 72.2 0.1 5.7e-20 71.0 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFW99267.1 - 4.9e-20 71.3 0.1 1e-19 70.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 EFW99267.1 - 0.084 12.4 1.4 0.18 11.3 1.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mitoc_L55 PF09776.4 EFW99267.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 Strep_his_triad PF04270.8 EFW99267.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Streptococcal histidine triad protein GAF_2 PF13185.1 EFW99268.1 - 0.0055 17.2 0.1 0.027 14.9 0.0 1.8 1 1 0 1 1 1 1 GAF domain NMD3 PF04981.8 EFW99269.1 - 2.8e-72 242.6 1.2 4.1e-72 242.1 0.8 1.3 1 0 0 1 1 1 1 NMD3 family GHMP_kinases_N PF00288.21 EFW99269.1 - 1.7e-14 53.6 3.0 5.9e-14 51.8 2.1 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFW99269.1 - 1.1e-07 31.9 0.0 2.9e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal DZR PF12773.2 EFW99269.1 - 0.069 12.9 6.4 1.4 8.7 1.8 2.8 2 1 0 2 2 2 0 Double zinc ribbon TFIIA PF03153.8 EFW99269.1 - 0.58 9.9 9.0 0.94 9.3 6.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF35_N PF12172.3 EFW99269.1 - 0.91 9.5 6.3 0.097 12.6 0.2 2.6 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Zn_clus PF00172.13 EFW99270.1 - 0.0088 15.9 5.4 0.016 15.0 3.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNase_T PF00929.19 EFW99271.1 - 6.4e-25 88.3 0.0 9.4e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Exonuclease adh_short PF00106.20 EFW99272.1 - 3.5e-12 46.5 0.1 8.9e-12 45.2 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFW99272.1 - 3.2e-05 23.6 0.0 6.9e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFW99272.1 - 0.031 13.6 0.0 0.15 11.5 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFW99272.1 - 0.13 12.3 0.1 0.38 10.7 0.0 1.9 1 1 0 1 1 1 0 NADH(P)-binding Acyltransferase PF01553.16 EFW99273.1 - 3.2e-19 68.6 0.0 8e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Asp PF00026.18 EFW99274.1 - 4.7e-70 236.3 10.1 5.9e-70 236.0 7.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFW99274.1 - 3.3e-06 27.1 0.0 2.5e-05 24.2 0.0 2.4 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFW99274.1 - 8.1e-06 26.2 6.2 0.0018 18.7 1.4 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 EFW99274.1 - 0.0048 16.4 0.1 0.014 14.9 0.0 1.9 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Acyl_transf_3 PF01757.17 EFW99275.1 - 2.5e-31 108.7 16.1 3.7e-31 108.2 11.1 1.3 1 0 0 1 1 1 1 Acyltransferase family DUF1049 PF06305.6 EFW99275.1 - 7.2 6.1 7.6 1.2 8.6 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) MFS_1 PF07690.11 EFW99276.1 - 8.8e-08 31.2 10.0 1e-07 31.0 7.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Ribosomal_L17 PF01196.14 EFW99277.1 - 1.4e-31 108.9 0.0 3e-31 107.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L17 BBP1_C PF15272.1 EFW99277.1 - 0.2 11.1 0.9 0.36 10.3 0.6 1.3 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Prog_receptor PF02161.10 EFW99278.1 - 0.0091 14.8 9.2 0.015 14.1 6.4 1.3 1 0 0 1 1 1 1 Progesterone receptor DUF572 PF04502.8 EFW99278.1 - 0.22 10.7 10.5 0.37 9.9 7.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Pex26 PF07163.7 EFW99278.1 - 0.37 9.6 4.9 0.19 10.6 1.6 1.8 2 0 0 2 2 2 0 Pex26 protein MARVEL PF01284.18 EFW99279.1 - 3.6e-22 78.7 11.5 4.2e-22 78.5 7.9 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF3098 PF11297.3 EFW99279.1 - 0.087 12.5 1.5 0.2 11.3 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) Cation_ATPase_C PF00689.16 EFW99279.1 - 1.3 8.4 6.7 94 2.4 4.6 2.5 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus MpPF26 PF07666.6 EFW99279.1 - 4.2 7.2 9.6 34 4.3 4.4 2.4 2 1 0 2 2 2 0 M penetrans paralogue family 26 FA_desaturase PF00487.19 EFW99279.1 - 4.4 6.6 10.9 0.38 10.1 3.5 1.8 1 1 1 2 2 2 0 Fatty acid desaturase BTB PF00651.26 EFW99280.1 - 4e-25 87.9 0.0 2.5e-12 46.7 0.1 3.4 3 0 0 3 3 3 2 BTB/POZ domain Ank_4 PF13637.1 EFW99280.1 - 8.2e-08 32.5 0.0 2.8e-07 30.8 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFW99280.1 - 9e-08 32.3 0.0 2.3e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFW99280.1 - 1.1e-06 28.6 0.0 3.3e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 EFW99280.1 - 1.3e-06 27.8 0.1 4.8e-06 26.1 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 EFW99280.1 - 0.001 19.1 0.0 0.0048 17.0 0.0 2.2 1 0 0 1 1 1 1 Ankyrin repeat Mt_ATP-synt_D PF05873.7 EFW99281.1 - 9.9e-17 61.0 1.7 1.2e-16 60.7 1.2 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Dor1 PF04124.7 EFW99281.1 - 0.043 12.2 0.8 0.053 11.9 0.6 1.1 1 0 0 1 1 1 0 Dor1-like family Phage_GP20 PF06810.6 EFW99281.1 - 0.056 12.8 0.7 2.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 Tropomyosin_1 PF12718.2 EFW99281.1 - 0.067 13.0 1.0 8.7 6.1 0.2 2.2 2 0 0 2 2 2 0 Tropomyosin like RasGAP_C PF03836.10 EFW99281.1 - 0.14 11.8 0.4 0.4 10.3 0.0 1.8 2 0 0 2 2 2 0 RasGAP C-terminus MFS_1 PF07690.11 EFW99282.1 - 2.1e-30 105.6 33.2 5.6e-24 84.5 4.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFW99282.1 - 0.0045 15.2 1.2 0.0073 14.5 0.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ceramidase PF05875.7 EFW99283.1 - 7.9e-62 208.7 11.6 1.1e-61 208.2 8.0 1.1 1 0 0 1 1 1 1 Ceramidase DUF202 PF02656.10 EFW99283.1 - 1.8 8.8 9.8 3.4 7.9 3.4 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF202) DUF308 PF03729.8 EFW99283.1 - 2.3 8.2 13.5 0.086 12.8 1.7 3.3 3 1 0 3 3 3 0 Short repeat of unknown function (DUF308) Ribosomal_L18e PF00828.14 EFW99284.1 - 4.3e-24 85.3 0.1 7.6e-24 84.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Adap_comp_sub PF00928.16 EFW99285.1 - 1.3e-53 181.8 0.0 2e-53 181.1 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family But2 PF09792.4 EFW99286.1 - 0.00021 21.0 0.0 0.00075 19.2 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Cyclase PF04199.8 EFW99287.1 - 1.2e-17 64.1 0.0 1.6e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase UPF0047 PF01894.12 EFW99288.1 - 1.6e-40 137.5 0.0 1.8e-40 137.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 FtsJ PF01728.14 EFW99289.1 - 4e-61 206.1 0.0 4.9e-61 205.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 EFW99289.1 - 4.4e-05 23.2 0.0 6.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99289.1 - 0.0039 17.7 0.0 0.032 14.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain DEAD PF00270.24 EFW99290.1 - 3.7e-39 133.9 0.0 6.3e-39 133.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99290.1 - 3.9e-18 65.0 0.0 8e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 EFW99290.1 - 1.1e-15 56.9 0.0 2.4e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 EFW99290.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFW99291.1 - 0.0021 18.2 0.0 0.016 15.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 EFW99291.1 - 0.094 12.9 0.1 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFW99291.1 - 0.12 13.2 0.0 0.36 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain NTF2 PF02136.15 EFW99292.1 - 1e-24 87.1 0.3 1.6e-24 86.5 0.2 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 EFW99292.1 - 7.6e-08 31.8 0.0 1.3e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99292.1 - 1.5e-06 28.0 0.0 3.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99292.1 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFW99292.1 - 0.031 14.0 0.0 0.081 12.7 0.0 1.8 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif NAC PF01849.13 EFW99293.1 - 1.1e-24 85.7 0.2 2.5e-24 84.5 0.0 1.7 2 0 0 2 2 2 1 NAC domain UBA PF00627.26 EFW99293.1 - 2.6e-05 23.8 1.1 4.6e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Ribosomal_S13 PF00416.17 EFW99293.1 - 0.11 12.9 2.0 1.2 9.6 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein S13/S18 Daxx PF03344.10 EFW99293.1 - 0.18 10.2 20.5 0.14 10.6 9.5 2.0 2 0 0 2 2 2 0 Daxx Family SelP_N PF04592.9 EFW99293.1 - 0.53 9.6 15.8 0.031 13.6 7.3 1.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region CDC45 PF02724.9 EFW99293.1 - 0.63 8.0 15.0 0.02 12.9 4.3 1.9 2 0 0 2 2 2 0 CDC45-like protein CAF1-p150_C2 PF15539.1 EFW99293.1 - 3.9 6.4 6.9 8.9 5.3 3.4 2.0 2 0 0 2 2 2 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term Myc_N PF01056.13 EFW99293.1 - 7 5.7 15.0 0.22 10.6 3.7 2.1 2 0 0 2 2 2 0 Myc amino-terminal region JAB PF01398.16 EFW99295.1 - 5.1e-17 61.6 0.0 7.3e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 EFW99295.1 - 6.1e-08 32.7 0.0 1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function NIR_SIR PF01077.17 EFW99296.1 - 1.6e-51 173.7 0.0 9.2e-45 151.8 0.0 2.5 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 EFW99296.1 - 6.1e-29 99.4 0.0 3e-14 52.3 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 EFW99296.1 - 7.5e-28 97.3 0.0 2.2e-27 95.7 0.0 1.9 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.14 EFW99296.1 - 1.6e-08 34.3 1.0 2.6e-08 33.6 0.2 1.7 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Flavodoxin_5 PF12724.2 EFW99296.1 - 0.024 14.6 0.0 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain Glyco_hydro_35 PF01301.14 EFW99297.1 - 1.1e-74 251.7 2.1 1.6e-74 251.0 1.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.1 EFW99297.1 - 6.5e-50 168.0 1.2 4.1e-24 85.0 0.0 2.9 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.4 EFW99297.1 - 3.9e-40 137.1 4.8 7.2e-40 136.2 3.3 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.1 EFW99297.1 - 1.7e-11 43.3 0.0 8e-11 41.1 0.0 2.2 1 1 0 1 1 1 1 Beta-galactosidase, domain 3 Cellulase PF00150.13 EFW99297.1 - 0.0033 16.6 0.1 0.044 12.9 0.0 2.5 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF1183 PF06682.7 EFW99299.1 - 5.9e-59 200.2 15.1 5.1e-56 190.5 10.5 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1183) DUF2763 PF10961.3 EFW99299.1 - 4.2 7.8 12.1 2.5 8.5 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) DUF155 PF02582.9 EFW99300.1 - 5.9e-59 198.8 0.1 9.7e-59 198.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 E1-E2_ATPase PF00122.15 EFW99300.1 - 1.3e-54 184.6 0.1 1.3e-54 184.6 0.1 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 EFW99300.1 - 3.3e-44 151.8 5.0 3.3e-44 151.8 3.5 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 EFW99300.1 - 2.1e-43 146.2 1.1 4.5e-12 45.9 0.0 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain HAD PF12710.2 EFW99300.1 - 4.1e-14 53.2 0.0 1.1e-13 51.8 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFW99300.1 - 4.8e-05 23.0 3.5 0.00012 21.7 0.7 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DSBA PF01323.15 EFW99300.1 - 0.12 11.9 3.6 3.2 7.2 0.0 3.6 3 0 0 3 3 3 0 DSBA-like thioredoxin domain DNA_pol_phi PF04931.8 EFW99300.1 - 3.4 5.3 7.4 4.9 4.8 5.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi RRM_1 PF00076.17 EFW99301.1 - 4.5e-07 29.4 0.0 5.8e-05 22.6 0.0 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99301.1 - 7.2e-07 29.1 0.0 2.3e-06 27.4 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99301.1 - 1.6e-05 24.6 0.0 0.00019 21.1 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mg_trans_NIPA PF05653.9 EFW99302.1 - 2e-15 56.5 11.1 6.7e-15 54.8 7.7 1.7 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.15 EFW99302.1 - 7.1e-05 22.8 15.4 0.00011 22.2 0.1 3.3 2 1 1 3 3 3 2 EamA-like transporter family Robl_LC7 PF03259.12 EFW99303.1 - 1.7e-07 30.7 0.0 3.2e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 Roadblock/LC7 domain IncA PF04156.9 EFW99304.1 - 0.0089 15.6 10.4 0.0089 15.6 7.2 3.9 1 1 2 3 3 3 1 IncA protein Reo_sigmaC PF04582.7 EFW99304.1 - 0.042 13.0 18.5 0.19 10.8 0.8 3.2 1 1 2 3 3 3 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 EFW99304.1 - 0.14 10.6 44.7 0.56 8.5 19.7 2.2 1 1 1 2 2 2 0 AAA domain NPV_P10 PF05531.7 EFW99304.1 - 1.7 8.9 23.8 0.17 12.1 0.4 5.0 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein CAF1 PF04857.15 EFW99305.1 - 1e-65 221.6 0.0 1.3e-65 221.3 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease dsDNA_bind PF01984.15 EFW99307.1 - 1.6e-29 102.0 18.6 1.6e-29 102.0 12.9 2.6 2 0 0 2 2 2 1 Double-stranded DNA-binding domain ApbA_C PF08546.6 EFW99307.1 - 3.1e-16 59.4 0.8 5.4e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFW99307.1 - 2.8e-11 43.0 0.0 8.4e-11 41.5 0.0 1.8 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Spt20 PF12090.3 EFW99307.1 - 0.086 12.1 1.5 0.16 11.3 1.0 1.4 1 0 0 1 1 1 0 Spt20 family Fes1 PF08609.5 EFW99307.1 - 0.25 11.8 0.8 1 9.9 0.5 2.1 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 EF-1_beta_acid PF10587.4 EFW99307.1 - 0.29 11.3 8.6 0.072 13.2 1.8 3.1 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region Aldo_ket_red PF00248.16 EFW99308.1 - 6.2e-58 195.8 0.0 8.1e-58 195.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family HET PF06985.6 EFW99310.1 - 2.3e-24 86.1 1.5 3.9e-24 85.3 1.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Zn_clus PF00172.13 EFW99311.1 - 9.3e-08 31.8 8.7 9.3e-08 31.8 6.0 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFW99311.1 - 2.3e-05 23.2 0.2 3.5e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain UPF0075 PF03702.9 EFW99312.1 - 8e-83 278.3 0.0 9.3e-83 278.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0075) WD40 PF00400.27 EFW99313.1 - 5.7e-30 102.1 14.2 1.3e-08 34.3 0.0 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat eIF2A PF08662.6 EFW99313.1 - 1.8e-06 27.7 0.2 0.038 13.7 0.0 3.4 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 EFW99313.1 - 0.092 12.2 0.0 2.7 7.5 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain A_deaminase PF00962.17 EFW99314.1 - 1.6e-43 148.8 0.0 4.7e-43 147.3 0.0 1.7 2 0 0 2 2 2 1 Adenosine/AMP deaminase Acyltransferase PF01553.16 EFW99315.1 - 4.9e-05 22.7 0.0 0.0001 21.7 0.0 1.7 1 1 0 1 1 1 1 Acyltransferase Ank_2 PF12796.2 EFW99316.1 - 3.4e-43 145.8 0.1 2.3e-15 56.7 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99316.1 - 4.4e-38 127.2 0.0 1.6e-06 27.6 0.0 6.1 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.1 EFW99316.1 - 1.2e-34 117.5 13.0 1.2e-08 34.9 0.1 4.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFW99316.1 - 5e-31 106.5 3.4 5.6e-07 29.8 0.0 5.1 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99316.1 - 1.1e-30 102.6 0.0 0.00078 19.4 0.0 6.1 6 0 0 6 6 6 6 Ankyrin repeat OmpA PF00691.15 EFW99316.1 - 0.58 10.6 2.5 88 3.6 0.0 3.6 1 1 2 3 3 3 0 OmpA family Neil1-DNA_bind PF09292.5 EFW99316.1 - 4.6 7.1 5.6 2.1e+02 1.7 0.0 4.2 5 0 0 5 5 5 0 Endonuclease VIII-like 1, DNA bind TFR_dimer PF04253.10 EFW99317.1 - 7.2e-18 64.3 0.0 1.3e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 EFW99317.1 - 6.4e-16 58.5 0.0 1.1e-15 57.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFW99317.1 - 4.6e-08 32.6 0.1 1.1e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.10 EFW99317.1 - 0.077 12.2 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Nicastrin GvpD PF07088.6 EFW99318.1 - 0.022 13.1 0.1 0.034 12.4 0.1 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein DUF3053 PF11254.3 EFW99318.1 - 0.13 11.4 2.2 0.92 8.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) Fib_alpha PF08702.5 EFW99318.1 - 3.9 7.5 6.9 18 5.4 1.2 2.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family N2227 PF07942.7 EFW99319.1 - 1.3e-55 188.2 0.0 1.8e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 EFW99319.1 - 4.9e-08 32.8 0.0 9.9e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFW99319.1 - 9.8e-08 32.3 0.0 7.3e-07 29.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW99319.1 - 3.1e-05 23.9 0.0 9.3e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99319.1 - 3.9e-05 24.0 0.0 0.00014 22.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99319.1 - 7.1e-05 23.3 0.0 0.00023 21.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW99319.1 - 0.0023 18.2 0.0 0.0075 16.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW99319.1 - 0.004 16.7 0.0 0.075 12.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.1 EFW99319.1 - 0.0044 17.8 0.1 0.016 15.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFW99319.1 - 0.024 14.2 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.12 EFW99319.1 - 0.036 13.0 0.0 0.1 11.5 0.0 1.7 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Bin3 PF06859.7 EFW99319.1 - 0.051 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Sulfatase PF00884.18 EFW99320.1 - 2e-54 184.9 0.0 2.7e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.3 EFW99320.1 - 3.6e-22 77.9 2.2 4.7e-22 77.5 0.7 1.9 2 0 0 2 2 2 1 Choline sulfatase enzyme C terminal Med8 PF10232.4 EFW99320.1 - 9.7e-20 71.0 2.2 2.5e-19 69.7 1.5 1.6 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Phosphodiest PF01663.17 EFW99320.1 - 9.3e-08 31.7 0.0 2.3e-07 30.4 0.0 1.6 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CENP-B_dimeris PF09026.5 EFW99320.1 - 0.95 9.7 10.3 2.3 8.4 7.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.4 EFW99320.1 - 1.1 7.8 11.5 1.7 7.2 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.6 EFW99320.1 - 2.5 7.8 6.9 5.1 6.8 4.8 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP1_TM PF14812.1 EFW99320.1 - 3.2 8.1 10.8 8.8 6.7 7.5 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 EFW99320.1 - 3.7 7.0 13.2 6.4 6.2 9.1 1.2 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 EFW99320.1 - 8.5 5.5 6.4 13 4.9 4.4 1.2 1 0 0 1 1 1 0 NOA36 protein DDOST_48kD PF03345.9 EFW99321.1 - 3e-143 477.3 0.0 3.9e-143 476.9 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Beach PF02138.13 EFW99321.1 - 9.9e-107 356.3 0.0 1.5e-106 355.8 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 EFW99321.1 - 5.6e-13 48.6 0.1 1.7e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 EFW99321.1 - 4.4e-12 46.5 0.0 1.2e-11 45.1 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.27 EFW99321.1 - 1.4e-07 31.1 4.3 0.0044 16.8 0.0 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Nop14 PF04147.7 EFW99321.1 - 0.9 7.3 7.4 1.6 6.5 5.1 1.3 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.9 EFW99321.1 - 2.3 7.6 5.9 4.2 6.8 4.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Fmp27_WPPW PF10359.4 EFW99321.1 - 6.3 5.1 2.3 9.9 4.4 1.6 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Spc7_N PF15402.1 EFW99322.1 - 4.4e-153 511.5 117.8 2.2e-130 436.4 63.1 5.4 2 1 1 3 3 3 2 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.6 EFW99322.1 - 1.1e-85 287.1 7.0 1.1e-85 287.1 4.9 1.5 2 0 0 2 2 2 1 Spc7 kinetochore protein Spc7_C2 PF15577.1 EFW99322.1 - 2e-12 46.5 0.3 4.1e-12 45.5 0.2 1.5 1 0 0 1 1 1 1 Spc7_C2 Sugar_tr PF00083.19 EFW99323.1 - 7.2e-85 285.2 21.0 8.3e-85 285.0 14.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFW99323.1 - 3.9e-31 108.0 45.9 4.6e-26 91.3 17.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Keratin_assoc PF09775.4 EFW99323.1 - 0.056 12.9 0.1 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Keratinocyte-associated protein 2 FCH PF00611.18 EFW99324.1 - 5.2e-24 84.2 3.8 9.4e-24 83.4 0.0 3.2 3 2 1 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.1 EFW99324.1 - 5.7e-22 77.0 0.5 4.8e-12 45.2 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.17 EFW99324.1 - 1.4e-14 53.5 5.6 2.1e-14 52.9 3.9 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.23 EFW99324.1 - 4.7e-14 51.4 0.1 2.2e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_3 PF08239.6 EFW99324.1 - 0.00011 22.2 0.4 0.0042 17.2 0.1 2.5 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_2 PF07653.12 EFW99324.1 - 0.0039 16.6 0.0 0.56 9.7 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain LOH1CR12 PF10158.4 EFW99324.1 - 0.055 13.2 0.2 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Tumour suppressor protein Allexi_40kDa PF05549.6 EFW99324.1 - 0.13 11.4 3.7 0.1 11.8 0.2 2.3 2 1 1 3 3 3 0 Allexivirus 40kDa protein Spc7 PF08317.6 EFW99324.1 - 0.15 10.7 13.6 0.65 8.6 1.1 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein C1_2 PF03107.11 EFW99324.1 - 0.55 10.3 7.8 0.96 9.6 5.4 1.4 1 0 0 1 1 1 0 C1 domain Ins_P5_2-kin PF06090.7 EFW99325.1 - 4.3e-33 114.6 0.0 5.5e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Fungal_trans_2 PF11951.3 EFW99326.1 - 1.4e-09 37.0 0.1 2.3e-09 36.3 0.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain MRP-S28 PF10213.4 EFW99327.1 - 1.5e-44 151.1 0.0 2.5e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein LTXXQ PF07813.7 EFW99327.1 - 1.8e-05 25.1 5.3 0.51 10.8 0.0 3.4 3 0 0 3 3 3 2 LTXXQ motif family protein Jnk-SapK_ap_N PF09744.4 EFW99327.1 - 0.11 12.4 0.8 0.2 11.6 0.6 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Fibrinogen_BP PF08017.6 EFW99328.1 - 5.2e-07 28.2 0.5 6.3e-07 27.9 0.3 1.0 1 0 0 1 1 1 1 Fibrinogen binding protein S_100 PF01023.14 EFW99328.1 - 0.0083 15.4 13.9 23 4.4 0.0 5.6 6 0 0 6 6 6 5 S-100/ICaBP type calcium binding domain Aminotran_5 PF00266.14 EFW99329.1 - 2e-93 313.1 0.0 2.4e-93 312.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFW99329.1 - 7.4e-09 35.1 0.0 8.8e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EFW99329.1 - 5.9e-06 25.5 0.1 3e-05 23.2 0.1 1.9 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family SIS_2 PF13580.1 EFW99329.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 SIS domain Ras PF00071.17 EFW99330.1 - 9.8e-49 164.8 0.1 1.2e-48 164.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFW99330.1 - 2e-12 47.6 0.0 3.7e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFW99330.1 - 5.3e-12 45.3 0.3 6.4e-12 45.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFW99330.1 - 3e-07 30.0 0.0 3.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFW99330.1 - 0.0033 16.6 0.1 0.0041 16.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF1907 PF08925.6 EFW99331.1 - 6.2e-95 317.5 0.0 7.1e-95 317.3 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) Myb_DNA-bind_6 PF13921.1 EFW99332.1 - 0.057 13.5 0.0 0.21 11.6 0.0 2.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain PCI PF01399.22 EFW99333.1 - 4.5e-05 23.7 0.0 8.8e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 PCI domain DUF3246 PF11596.3 EFW99333.1 - 0.023 14.0 0.9 0.023 14.0 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) ERM PF00769.14 EFW99333.1 - 0.034 13.6 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF1687 PF07955.6 EFW99334.1 - 4.6e-19 68.7 0.3 3.5e-18 65.8 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) ArsC PF03960.10 EFW99334.1 - 0.052 13.6 0.0 1.6 8.8 0.0 2.3 1 1 0 1 1 1 0 ArsC family Pneumo_att_G PF05539.6 EFW99334.1 - 0.13 11.6 2.7 0.14 11.4 1.8 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Pkinase PF00069.20 EFW99335.1 - 1.7e-58 197.8 0.0 2.2e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99335.1 - 1.6e-25 89.6 0.0 2.3e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99335.1 - 0.00013 21.0 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFW99335.1 - 0.015 15.0 7.2 0.2 11.3 0.0 3.3 3 1 0 4 4 4 0 Phosphotransferase enzyme family Kdo PF06293.9 EFW99335.1 - 0.021 13.8 0.0 0.04 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acatn PF13000.2 EFW99336.1 - 2e-119 399.6 22.6 3.3e-69 233.8 7.4 3.9 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 SPT16 PF08644.6 EFW99337.1 - 1.4e-56 190.5 0.1 1.4e-56 190.5 0.0 3.4 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 EFW99337.1 - 1.1e-53 181.1 3.3 1.5e-53 180.6 0.2 2.6 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 EFW99337.1 - 9.2e-24 84.1 0.0 1.6e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 EFW99337.1 - 1.5e-21 76.1 0.1 4.1e-21 74.7 0.0 1.8 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Arylsulfotran_2 PF14269.1 EFW99338.1 - 1.7e-43 148.8 0.0 2.6e-43 148.2 0.0 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 EFW99338.1 - 4.9e-12 45.1 0.1 6.8e-12 44.6 0.1 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Cwf_Cwc_15 PF04889.7 EFW99339.1 - 2.9 7.5 16.3 20 4.7 11.3 2.3 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sulfotransfer_3 PF13469.1 EFW99340.1 - 0.0067 17.3 2.3 0.0067 17.3 1.6 1.6 1 1 1 2 2 2 1 Sulfotransferase family TauD PF02668.11 EFW99341.1 - 3.1e-54 184.3 0.6 3.9e-54 184.0 0.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family BRE1 PF08647.6 EFW99342.1 - 3.2e-28 97.5 8.9 3.2e-28 97.5 6.2 5.2 5 0 0 5 5 5 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.1 EFW99342.1 - 3.3e-09 36.6 9.9 5.7e-09 35.8 6.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFW99342.1 - 3.3e-08 33.1 10.1 6e-08 32.2 7.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFW99342.1 - 3.9e-08 32.8 8.4 6.5e-08 32.1 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFW99342.1 - 1.3e-07 31.3 7.5 2.2e-07 30.5 5.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFW99342.1 - 1.4e-07 31.0 9.8 2.6e-07 30.1 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFW99342.1 - 3.1e-05 23.5 5.7 7.6e-05 22.3 3.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EFW99342.1 - 0.00018 21.2 7.2 0.00041 20.1 5.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Snapin_Pallidin PF14712.1 EFW99342.1 - 0.0053 17.0 4.3 0.0053 17.0 3.0 6.4 5 2 1 7 7 7 1 Snapin/Pallidin zf-RING_6 PF14835.1 EFW99342.1 - 0.0071 16.0 2.7 0.016 15.0 1.8 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.1 EFW99342.1 - 0.014 14.9 2.2 0.026 14.0 1.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.2 EFW99342.1 - 0.019 15.0 8.0 0.056 13.5 5.6 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger zf-RING_4 PF14570.1 EFW99342.1 - 0.091 12.3 6.9 0.51 9.9 5.0 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Vac_Fusion PF02346.11 EFW99342.1 - 0.2 11.1 11.2 4.3 6.8 0.0 5.5 7 0 0 7 7 7 0 Chordopoxvirus fusion protein DUF1272 PF06906.6 EFW99342.1 - 0.26 11.1 5.5 0.52 10.1 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Reo_sigmaC PF04582.7 EFW99342.1 - 0.66 9.0 23.6 0.63 9.1 3.1 3.9 1 1 2 4 4 4 0 Reovirus sigma C capsid protein DUF2018 PF09442.5 EFW99342.1 - 0.93 10.1 5.5 5.2 7.6 0.2 3.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) FYVE PF01363.16 EFW99342.1 - 1.8 8.5 10.9 20 5.1 7.6 2.3 1 1 1 2 2 2 0 FYVE zinc finger zf-C2H2_6 PF13912.1 EFW99342.1 - 2.2 8.3 4.8 2.6 8.0 0.0 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger FCH PF00611.18 EFW99343.1 - 1.7e-19 69.8 2.7 2.7e-19 69.1 0.0 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.23 EFW99343.1 - 6e-14 51.1 0.0 1.2e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EFW99343.1 - 3.5e-12 45.6 0.0 1.4e-11 43.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.1 EFW99343.1 - 8.8e-11 41.2 0.1 1.7e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Pkinase PF00069.20 EFW99344.1 - 3.5e-75 252.4 0.0 4.5e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99344.1 - 1.6e-35 122.4 0.0 2.8e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99344.1 - 0.012 14.6 0.0 0.027 13.4 0.0 1.6 1 1 0 1 1 1 0 Kinase-like PHF5 PF03660.9 EFW99345.1 - 4.5e-52 174.6 9.9 5e-52 174.4 6.9 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.2 EFW99345.1 - 0.84 9.4 15.4 0.19 11.5 5.4 2.8 1 1 2 3 3 3 0 Double zinc ribbon Prok-RING_1 PF14446.1 EFW99345.1 - 1.9 8.2 16.1 2.9 7.6 0.5 3.0 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 PHD PF00628.24 EFW99345.1 - 7.2 6.3 15.4 0.2 11.4 4.4 2.5 1 1 1 2 2 2 0 PHD-finger PolC_DP2 PF03833.8 EFW99345.1 - 9.4 3.7 6.8 9.7 3.7 4.7 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 tRNA-synt_1 PF00133.17 EFW99346.1 - 8.7e-199 661.4 0.0 1.1e-198 661.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EFW99346.1 - 2e-25 89.3 0.0 4.5e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EFW99346.1 - 5e-19 68.2 1.7 1.6e-07 30.3 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 EFW99346.1 - 0.0035 16.5 0.0 0.024 13.7 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain WD40 PF00400.27 EFW99347.1 - 4e-47 156.4 30.3 1.4e-07 31.1 0.5 10.6 11 0 0 11 11 11 8 WD domain, G-beta repeat Nup160 PF11715.3 EFW99347.1 - 0.0043 15.2 1.4 0.029 12.4 0.1 2.8 4 0 0 4 4 4 1 Nucleoporin Nup120/160 PD40 PF07676.7 EFW99347.1 - 0.013 15.1 0.2 2 8.1 0.0 4.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat NHL PF01436.16 EFW99347.1 - 0.12 12.3 1.2 0.66 10.0 0.1 3.0 2 0 0 2 2 2 0 NHL repeat VQ PF05678.9 EFW99347.1 - 0.19 10.7 1.2 0.41 9.7 0.8 1.6 1 0 0 1 1 1 0 VQ motif PQQ_3 PF13570.1 EFW99347.1 - 0.96 9.8 25.1 1.7 8.9 0.1 6.8 7 1 1 8 8 8 0 PQQ-like domain DUF1077 PF06417.7 EFW99348.1 - 1.1e-51 173.4 1.5 1.3e-51 173.1 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) NUDIX_2 PF13869.1 EFW99349.1 - 5.2e-81 270.4 0.0 6.1e-81 270.2 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase F-box PF00646.28 EFW99350.1 - 4.9e-06 26.0 0.3 1e-05 25.0 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFW99350.1 - 8.9e-06 25.3 0.1 1.6e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 F-box-like cwf18 PF08315.7 EFW99352.1 - 1.1e-36 126.0 11.1 2.5e-36 124.9 3.3 2.8 2 1 0 2 2 2 1 cwf18 pre-mRNA splicing factor Abhydrolase_3 PF07859.8 EFW99354.1 - 1.2e-28 100.1 0.1 2e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFW99354.1 - 0.0023 17.8 2.4 0.0023 17.8 1.7 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFW99354.1 - 0.028 14.1 0.0 1.5 8.5 0.1 2.3 1 1 1 2 2 2 0 Alpha/beta hydrolase family DUF3123 PF11321.3 EFW99355.1 - 6.6 7.0 9.1 9.4 6.5 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) TPR_11 PF13414.1 EFW99356.1 - 1.5e-10 40.5 12.0 5.7e-10 38.7 5.5 2.5 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 EFW99356.1 - 9.7e-07 28.6 9.0 2.5e-06 27.3 6.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFW99356.1 - 0.00019 20.9 3.3 0.04 13.7 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFW99356.1 - 0.00026 20.6 11.9 0.018 14.9 0.8 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFW99356.1 - 0.00028 20.3 5.9 0.22 11.2 0.3 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFW99356.1 - 0.0067 17.0 5.8 0.0067 17.0 4.0 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat CDV3 PF15359.1 EFW99356.1 - 0.015 15.3 2.3 0.044 13.8 1.6 1.8 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 TPR_6 PF13174.1 EFW99356.1 - 0.042 14.3 4.8 34 5.1 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFW99356.1 - 0.81 9.7 7.3 0.78 9.7 0.7 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Vfa1 PF08432.5 EFW99356.1 - 1 9.3 8.7 0.063 13.2 2.1 1.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PS_Dcarbxylase PF02666.10 EFW99357.1 - 2.4e-52 177.2 0.0 3.4e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 EFW99357.1 - 8.1e-34 115.3 0.1 8.6e-18 63.9 0.0 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.1 EFW99357.1 - 0.00087 19.3 0.2 0.0033 17.5 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 EFW99357.1 - 0.0014 17.7 0.0 0.004 16.3 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 EFW99357.1 - 0.01 15.6 0.5 0.044 13.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain CEP76-C2 PF15627.1 EFW99357.1 - 0.015 14.8 0.0 1.6 8.2 0.0 2.5 2 0 0 2 2 2 0 CEP76 C2 domain EF-hand_5 PF13202.1 EFW99357.1 - 0.025 13.9 0.0 0.08 12.3 0.0 1.9 1 0 0 1 1 1 0 EF hand GCS PF03074.11 EFW99358.1 - 1.4e-151 504.7 0.0 2.9e-122 408.3 0.0 2.6 2 1 1 3 3 3 2 Glutamate-cysteine ligase SCP2 PF02036.12 EFW99359.1 - 7.7e-21 74.3 1.0 1e-20 73.9 0.7 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 EFW99359.1 - 0.00017 21.5 0.1 0.00024 21.0 0.1 1.4 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.1 EFW99359.1 - 0.002 17.5 0.0 0.0024 17.2 0.0 1.1 1 0 0 1 1 1 1 Sterol carrier protein domain Scm3 PF10384.4 EFW99360.1 - 3.3e-15 55.3 0.0 8e-15 54.0 0.0 1.7 1 0 0 1 1 1 1 Centromere protein Scm3 FAD_binding_4 PF01565.18 EFW99361.1 - 1.1e-23 83.2 2.4 2.1e-23 82.3 1.6 1.5 1 0 0 1 1 1 1 FAD binding domain Seipin PF06775.9 EFW99362.1 - 1.4e-44 151.9 0.0 1.9e-44 151.5 0.0 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) B3_4 PF03483.12 EFW99363.1 - 1.4e-24 86.4 0.1 2.7e-24 85.5 0.1 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 EFW99363.1 - 1.5e-14 53.5 0.0 2e-13 49.9 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase B5 domain MFS_2 PF13347.1 EFW99363.1 - 0.0097 14.3 0.1 0.0097 14.3 0.0 2.5 2 1 1 3 3 3 2 MFS/sugar transport protein OATP PF03137.15 EFW99363.1 - 0.12 10.3 0.0 0.2 9.6 0.0 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Rad60-SLD_2 PF13881.1 EFW99364.1 - 1.1e-11 44.6 0.1 2.7e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EFW99364.1 - 5.1e-05 22.5 0.0 0.0001 21.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 EFW99364.1 - 0.00054 20.1 0.1 0.0014 18.7 0.0 1.7 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ER_lumen_recept PF00810.13 EFW99367.1 - 3.2e-35 121.7 9.5 4.9e-35 121.1 6.6 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor BioY PF02632.9 EFW99367.1 - 1.1 8.8 4.6 0.54 9.9 0.7 2.1 2 0 0 2 2 2 0 BioY family Sec1 PF00995.18 EFW99368.1 - 1.1e-145 486.5 0.0 1.2e-145 486.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Peptidase_S8 PF00082.17 EFW99369.1 - 1.2e-52 178.8 8.7 1.7e-52 178.3 6.1 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EFW99369.1 - 5.6e-19 68.4 0.0 1e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Ipi1_N PF12333.3 EFW99370.1 - 2.8e-17 62.5 0.0 1.4e-16 60.2 0.0 2.3 1 1 0 1 1 1 1 Rix1 complex component involved in 60S ribosome maturation DUF4129 PF13559.1 EFW99372.1 - 0.8 9.7 9.3 1.1e+02 2.9 6.4 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) Tetraspannin PF00335.15 EFW99373.1 - 3.3e-06 26.5 10.1 4.8e-06 26.0 7.0 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4064 PF13273.1 EFW99373.1 - 0.21 11.7 2.3 1.3 9.1 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DEAD PF00270.24 EFW99374.1 - 2.9e-32 111.4 0.0 1.3e-31 109.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99374.1 - 3.9e-22 77.9 0.0 8.1e-22 76.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 EFW99374.1 - 0.00072 19.2 0.5 0.0085 15.8 0.0 2.6 3 0 0 3 3 3 1 Part of AAA domain AAA_22 PF13401.1 EFW99374.1 - 0.0093 16.1 0.1 0.36 10.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 EFW99374.1 - 0.021 14.3 0.0 0.073 12.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain Chitin_synth_1 PF01644.12 EFW99376.1 - 3.5e-82 274.0 0.1 5.5e-82 273.4 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EFW99376.1 - 3.6e-32 109.8 0.1 8.4e-32 108.7 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EFW99376.1 - 2.6e-21 75.6 4.9 1.1e-19 70.2 0.0 2.3 1 1 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 EFW99376.1 - 2e-09 37.4 0.8 2e-09 37.4 0.5 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFW99376.1 - 7.3e-07 29.2 0.0 1.4e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Nucleoside_tran PF01733.13 EFW99377.1 - 3.9e-29 101.8 29.4 7.6e-22 77.8 1.8 4.0 4 1 0 4 4 4 3 Nucleoside transporter Pinin_SDK_memA PF04696.8 EFW99377.1 - 5.4e-18 64.8 13.0 5.4e-18 64.8 9.0 2.0 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region ATP-synt_8 PF00895.15 EFW99377.1 - 0.0052 16.9 0.8 0.02 15.1 0.5 2.0 1 0 0 1 1 1 1 ATP synthase protein 8 COesterase PF00135.23 EFW99378.1 - 1.8e-89 300.9 0.0 2e-89 300.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFW99378.1 - 5.8e-06 26.0 0.1 1.1e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold MARVEL PF01284.18 EFW99379.1 - 5.7e-12 45.6 14.6 4.7e-11 42.6 10.0 2.0 1 1 1 2 2 2 2 Membrane-associating domain zf-C2H2 PF00096.21 EFW99380.1 - 7e-11 41.8 14.2 1.8e-05 24.8 1.1 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFW99380.1 - 8.9e-09 35.0 8.7 0.00015 21.8 0.3 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFW99380.1 - 1.5e-07 31.3 12.4 1.4e-06 28.3 0.9 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EFW99380.1 - 0.049 13.8 0.1 0.049 13.8 0.1 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 EFW99380.1 - 0.48 10.2 5.3 0.2 11.4 0.2 2.6 2 0 0 2 2 2 0 BED zinc finger BAF1_ABF1 PF04684.8 EFW99380.1 - 1.1 8.0 26.5 1.9 7.2 18.4 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Aldedh PF00171.17 EFW99381.1 - 2.4e-117 392.1 0.5 3.1e-117 391.7 0.4 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF2359 PF10151.4 EFW99381.1 - 0.01 14.4 0.2 0.015 13.8 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2359) Ceramidase_alk PF04734.8 EFW99382.1 - 2.5e-274 911.3 0.0 2.9e-274 911.1 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase tRNA-synt_1b PF00579.20 EFW99383.1 - 5.4e-57 193.1 0.0 7e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) ECR1_N PF14382.1 EFW99384.1 - 4.5e-11 41.8 0.1 1.2e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region DUF4536 PF15055.1 EFW99384.1 - 3.8e-05 23.6 0.3 3.8e-05 23.6 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) EXOSC1 PF10447.4 EFW99384.1 - 0.011 15.7 0.0 0.077 12.9 0.0 2.1 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 ECH PF00378.15 EFW99385.1 - 3.1e-41 141.1 0.1 5.5e-41 140.2 0.1 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 EFW99385.1 - 0.0042 17.2 1.2 0.0058 16.7 0.1 1.7 2 0 0 2 2 2 1 2-enoyl-CoA Hydratase C-terminal region Whi5 PF08528.6 EFW99387.1 - 2.1e-06 27.1 0.0 3.7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Whi5 like PPR_2 PF13041.1 EFW99388.1 - 3.6e-45 151.7 2.0 3.2e-08 33.4 0.0 13.6 9 2 6 15 15 15 10 PPR repeat family PPR PF01535.15 EFW99388.1 - 2.8e-24 83.3 19.0 0.00082 19.1 0.0 13.4 15 0 0 15 15 15 5 PPR repeat PPR_1 PF12854.2 EFW99388.1 - 1.3e-21 75.7 0.2 3.2e-08 32.9 0.0 9.5 10 0 0 10 10 10 4 PPR repeat PPR_3 PF13812.1 EFW99388.1 - 3.1e-21 73.8 29.5 4.8e-05 23.3 0.0 14.7 17 0 0 17 17 17 5 Pentatricopeptide repeat domain RPM2 PF08579.6 EFW99388.1 - 0.0011 19.0 0.0 0.063 13.4 0.0 3.6 4 0 0 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) ATP13 PF12921.2 EFW99388.1 - 0.11 11.9 0.1 29 4.0 0.0 3.7 4 0 0 4 4 4 0 Mitochondrial ATPase expression MR_MLE_C PF13378.1 EFW99389.1 - 1.1e-30 105.8 0.3 2.3e-30 104.8 0.1 1.6 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.11 EFW99389.1 - 4.1e-16 59.0 0.0 8.1e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MR_MLE PF01188.16 EFW99389.1 - 8.2e-10 39.0 0.0 2.8e-09 37.3 0.0 1.9 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain DUF1989 PF09347.5 EFW99390.1 - 6.6e-48 162.2 0.2 6.1e-47 159.1 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1989) Polysacc_deac_1 PF01522.16 EFW99390.1 - 9.5e-19 67.2 0.0 1.8e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.4 EFW99390.1 - 7.6e-05 22.2 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) HNH_2 PF13391.1 EFW99391.1 - 4.5e-15 55.1 0.0 7.7e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease Ribosomal_S19 PF00203.16 EFW99392.1 - 1.1e-33 114.7 0.4 1.5e-33 114.2 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ofd1_CTDD PF10637.4 EFW99393.1 - 1.2e-94 316.3 0.6 2.5e-85 285.8 1.4 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 EFW99393.1 - 2.9e-15 56.6 0.0 1e-14 54.8 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EFW99393.1 - 0.058 13.0 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DPPIV_N PF00930.16 EFW99394.1 - 9.1e-96 320.5 0.0 1.2e-95 320.1 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EFW99394.1 - 3.8e-52 176.6 1.0 6.4e-52 175.8 0.7 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFW99394.1 - 8.6e-11 41.7 2.0 1.1e-10 41.3 0.3 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 EFW99394.1 - 1.4e-05 24.6 1.9 0.00081 18.8 0.5 2.3 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PD40 PF07676.7 EFW99394.1 - 0.047 13.3 0.0 0.28 10.8 0.0 2.3 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat CHB_HEX PF03173.8 EFW99394.1 - 0.053 12.9 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 Putative carbohydrate binding domain PAF-AH_p_II PF03403.8 EFW99394.1 - 0.06 11.6 0.0 0.2 9.8 0.0 1.8 2 1 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF1640 PF07798.6 EFW99395.1 - 4.5e-62 209.2 6.3 5.3e-62 208.9 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) cwf21 PF08312.7 EFW99395.1 - 0.06 13.2 1.9 0.084 12.7 0.5 1.9 2 1 0 2 2 2 0 cwf21 domain ATP-synt_ab PF00006.20 EFW99396.1 - 6.3e-61 205.6 0.0 8.6e-61 205.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EFW99396.1 - 4.3e-18 65.8 0.1 8.1e-18 64.9 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EFW99396.1 - 2.8e-12 46.6 0.8 5.8e-12 45.6 0.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 EFW99396.1 - 0.00024 20.9 0.5 0.00054 19.8 0.4 1.6 1 0 0 1 1 1 1 HAS barrel domain Peptidase_S8 PF00082.17 EFW99397.1 - 7.2e-53 179.5 1.6 7.2e-53 179.5 1.1 2.1 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 EFW99397.1 - 4.7e-27 93.5 1.0 1.1e-26 92.4 0.7 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF2834 PF11196.3 EFW99397.1 - 0.043 13.9 0.4 0.1 12.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) zf-CCHC PF00098.18 EFW99399.1 - 6.6e-18 63.7 24.2 1.3e-08 34.3 0.7 4.5 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_2 PF13696.1 EFW99399.1 - 5.9e-06 25.6 7.5 0.039 13.4 0.0 3.3 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.1 EFW99399.1 - 0.00025 20.6 7.9 1.1 9.0 0.0 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.1 EFW99399.1 - 0.0013 18.3 13.9 0.31 10.7 0.3 3.5 3 0 0 3 3 3 3 Zinc knuckle PHD PF00628.24 EFW99399.1 - 0.16 11.6 11.9 2.9 7.6 0.2 3.3 2 1 1 3 3 3 0 PHD-finger Lar_restr_allev PF14354.1 EFW99399.1 - 6 7.2 10.3 6.6 7.1 1.8 2.5 1 1 1 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.2 EFW99399.1 - 7.6 6.4 15.7 1.9 8.3 2.4 3.0 2 1 1 3 3 3 0 Double zinc ribbon Rpr2 PF04032.11 EFW99399.1 - 8.8 6.2 11.0 16 5.4 2.0 2.4 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Saccharop_dh PF03435.13 EFW99401.1 - 6.2e-21 74.8 0.2 8.5e-21 74.3 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 EFW99401.1 - 0.12 12.7 0.0 0.34 11.2 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Ribosomal_L37ae PF01780.14 EFW99402.1 - 5.6e-38 128.7 9.9 6.1e-38 128.5 6.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.2 EFW99402.1 - 0.015 15.1 5.8 0.024 14.4 4.0 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-DHHC PF01529.15 EFW99402.1 - 0.022 14.1 1.1 0.027 13.8 0.8 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase PHD PF00628.24 EFW99402.1 - 1.4 8.6 7.3 8.6 6.1 0.1 2.1 1 1 1 2 2 2 0 PHD-finger Piwi PF02171.12 EFW99403.1 - 7.6e-69 231.9 0.0 1.1e-68 231.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain DUF1785 PF08699.5 EFW99403.1 - 4.2e-13 48.4 0.1 8.8e-13 47.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PAZ PF02170.17 EFW99403.1 - 9.7e-12 44.3 0.0 5.4e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 PAZ domain SIS PF01380.17 EFW99404.1 - 9.3e-57 190.2 0.1 7.5e-30 103.2 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 EFW99404.1 - 1.4e-28 99.6 0.0 1e-19 70.4 0.0 2.4 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EFW99404.1 - 9.9e-21 74.0 0.0 2.2e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EFW99404.1 - 2.1e-12 46.8 0.0 4.9e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 EFW99404.1 - 4.3e-07 28.8 0.0 7.4e-07 28.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DUF4637 PF15470.1 EFW99404.1 - 0.005 16.4 0.0 0.0094 15.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4637) PTSIIB_sorb PF03830.10 EFW99404.1 - 0.012 15.5 0.1 0.12 12.2 0.0 2.3 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component SIS_2 PF13580.1 EFW99404.1 - 0.079 12.6 0.0 0.44 10.2 0.0 2.2 2 0 0 2 2 2 0 SIS domain zf-CCCH PF00642.19 EFW99405.1 - 0.11 12.1 5.8 0.2 11.3 4.0 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) CDC45 PF02724.9 EFW99405.1 - 1.2 7.0 4.0 1.9 6.3 2.8 1.2 1 0 0 1 1 1 0 CDC45-like protein PhoD PF09423.5 EFW99406.1 - 2.7e-05 22.9 0.1 0.00018 20.2 0.1 1.9 1 1 0 1 1 1 1 PhoD-like phosphatase Pkinase PF00069.20 EFW99407.1 - 1e-66 224.7 0.0 1.7e-66 224.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99407.1 - 9.3e-31 106.8 0.0 1.7e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99407.1 - 0.00017 20.6 0.0 0.0005 19.1 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFW99407.1 - 0.031 13.3 0.9 0.065 12.2 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EFW99407.1 - 0.045 13.0 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 EFW99407.1 - 0.073 12.7 0.0 0.073 12.7 0.0 2.7 3 1 1 4 4 4 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 EFW99407.1 - 0.18 10.5 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase T2SE PF00437.15 EFW99408.1 - 0.00021 20.3 0.0 0.00035 19.5 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 EFW99408.1 - 0.00047 20.2 0.1 0.0046 17.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mur_ligase_M PF08245.7 EFW99408.1 - 0.0068 16.4 0.4 0.024 14.7 0.2 2.0 2 0 0 2 2 2 1 Mur ligase middle domain ABC_tran PF00005.22 EFW99408.1 - 0.047 13.9 0.0 0.047 13.9 0.0 2.6 2 1 0 2 2 2 0 ABC transporter FtsK_SpoIIIE PF01580.13 EFW99408.1 - 0.064 12.7 1.4 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family PhoH PF02562.11 EFW99408.1 - 0.066 12.4 0.0 0.21 10.7 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_23 PF13476.1 EFW99408.1 - 0.09 13.0 0.0 0.09 13.0 0.0 3.3 2 1 0 2 2 1 0 AAA domain AAA_14 PF13173.1 EFW99408.1 - 0.11 12.4 1.0 4.5 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 EFW99408.1 - 0.11 11.9 0.3 0.25 10.7 0.1 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.1 EFW99408.1 - 0.11 12.2 0.1 0.29 10.9 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 EFW99408.1 - 0.87 9.3 0.0 0.87 9.3 0.0 2.9 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AhpC-TSA PF00578.16 EFW99409.1 - 8.4e-16 57.7 0.0 4.7e-12 45.6 0.0 2.2 1 1 1 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 EFW99409.1 - 5.5e-08 32.4 0.0 5.6e-06 25.9 0.0 2.2 1 1 1 2 2 2 2 Redoxin AhpC-TSA_2 PF13911.1 EFW99409.1 - 0.0025 17.7 0.0 0.015 15.2 0.0 2.1 2 1 1 3 3 3 1 AhpC/TSA antioxidant enzyme Velvet PF11754.3 EFW99410.1 - 2e-54 184.3 0.0 3.7e-54 183.4 0.0 1.4 1 0 0 1 1 1 1 Velvet factor Glyco_transf_28 PF03033.15 EFW99411.1 - 1.3e-17 63.8 0.0 4.4e-17 62.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 EFW99411.1 - 3.7e-05 22.4 0.0 6.7e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 EFW99411.1 - 0.0031 17.1 0.0 0.0069 16.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Dabb PF07876.7 EFW99412.1 - 2.1e-21 76.1 0.3 1.5e-20 73.4 0.2 1.8 1 1 0 1 1 1 1 Stress responsive A/B Barrel Domain RNase_T PF00929.19 EFW99413.1 - 3.1e-19 69.8 0.0 5.1e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 EFW99413.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 3'-5' exonuclease Noc2 PF03715.8 EFW99414.1 - 7e-109 363.2 0.0 2.2e-108 361.6 0.0 1.8 1 1 0 1 1 1 1 Noc2p family KR PF08659.5 EFW99415.1 - 1.4e-60 204.0 0.7 5.5e-60 202.1 0.4 2.2 2 0 0 2 2 1 1 KR domain ketoacyl-synt PF00109.21 EFW99415.1 - 2.5e-60 204.1 0.5 1.2e-59 201.8 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFW99415.1 - 7.7e-54 183.1 0.1 2.2e-53 181.6 0.1 1.8 1 0 0 1 1 1 1 Acyl transferase domain adh_short PF00106.20 EFW99415.1 - 4.6e-46 156.7 2.5 6.3e-46 156.3 0.2 2.6 2 0 0 2 2 2 1 short chain dehydrogenase PS-DH PF14765.1 EFW99415.1 - 9.3e-46 156.3 2.4 2.6e-45 154.8 1.7 1.8 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 EFW99415.1 - 5.3e-34 116.6 0.0 1.6e-33 115.0 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.1 EFW99415.1 - 6.1e-17 62.7 0.1 4.6e-16 59.8 0.0 2.7 2 0 0 2 2 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFW99415.1 - 1.8e-16 59.8 0.1 4.3e-16 58.6 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 EFW99415.1 - 1.8e-07 31.3 0.1 5.2e-07 29.8 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.7 EFW99415.1 - 4.7e-06 26.9 0.0 1.5e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.7 EFW99415.1 - 0.00079 19.1 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_23 PF13489.1 EFW99415.1 - 0.0017 18.1 0.0 0.0065 16.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain CoA_trans PF01144.18 EFW99415.1 - 0.0037 16.4 0.0 0.01 15.0 0.0 1.7 1 0 0 1 1 1 1 Coenzyme A transferase NAD_binding_10 PF13460.1 EFW99415.1 - 0.0068 16.4 3.0 0.018 15.0 0.1 3.2 3 0 0 3 3 3 1 NADH(P)-binding NmrA PF05368.8 EFW99415.1 - 0.014 14.6 0.0 0.03 13.5 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family 3Beta_HSD PF01073.14 EFW99415.1 - 0.022 13.4 0.0 0.036 12.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFW99415.1 - 0.097 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFW99415.1 - 0.19 10.6 0.0 0.33 9.8 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF2619 PF10942.3 EFW99415.1 - 0.22 11.5 1.1 0.51 10.3 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2619) DUF3712 PF12505.3 EFW99416.1 - 8.1e-25 87.2 3.6 8.1e-25 87.2 2.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) DUF3602 PF12223.3 EFW99417.1 - 5.3e-16 58.7 20.3 8.1e-13 48.5 4.3 2.7 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) DUF3129 PF11327.3 EFW99418.1 - 4e-55 186.4 14.5 5e-55 186.1 10.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3129) CAP59_mtransfer PF11735.3 EFW99419.1 - 2e-75 253.1 0.0 2.9e-75 252.6 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 tRNA-synt_His PF13393.1 EFW99420.1 - 3.2e-30 105.2 0.6 9.6e-29 100.4 0.4 2.7 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 EFW99420.1 - 1.8e-16 60.2 0.0 2.6e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 EFW99420.1 - 3.8e-07 29.2 0.1 0.00026 19.8 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class II (D, K and N) HGTP_anticodon PF03129.15 EFW99420.1 - 0.0029 17.4 0.0 0.0068 16.3 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.15 EFW99420.1 - 0.088 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) ApoLp-III PF07464.6 EFW99422.1 - 0.062 13.3 6.7 0.12 12.3 4.7 1.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) TAF4 PF05236.9 EFW99422.1 - 0.22 10.7 6.1 0.063 12.5 2.4 1.4 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family DUF972 PF06156.8 EFW99422.1 - 1 9.7 9.2 0.82 10.0 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF948 PF06103.6 EFW99422.1 - 1.3 8.8 5.5 0.88 9.4 0.1 2.5 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) APG6 PF04111.7 EFW99422.1 - 2.2 7.2 8.5 2.6 7.0 5.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4600 PF15372.1 EFW99422.1 - 2.3 8.4 8.2 1.1 9.4 4.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) FlaC_arch PF05377.6 EFW99422.1 - 6 6.8 9.0 13 5.7 0.0 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) H_lectin PF09458.5 EFW99423.1 - 3.7e-06 26.5 0.1 9.3e-05 22.0 0.0 2.3 1 1 1 2 2 2 2 H-type lectin domain Fib_alpha PF08702.5 EFW99423.1 - 0.0074 16.4 0.1 0.011 15.9 0.1 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 EFW99423.1 - 0.014 15.1 1.0 0.02 14.6 0.7 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 EFW99423.1 - 0.08 13.3 0.7 0.13 12.6 0.5 1.3 1 0 0 1 1 1 0 SlyX SET PF00856.23 EFW99424.1 - 3.2e-14 53.5 0.0 1.6e-13 51.3 0.0 2.1 2 1 0 2 2 2 1 SET domain Cullin PF00888.17 EFW99426.1 - 1.1e-111 374.2 0.0 3.4e-111 372.6 0.0 1.8 2 0 0 2 2 2 1 Cullin family PI3_PI4_kinase PF00454.22 EFW99426.1 - 1.3e-43 149.1 0.0 2.3e-43 148.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 EFW99426.1 - 1.1e-33 116.2 0.1 3.6e-33 114.4 0.1 2.0 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair Cullin_Nedd8 PF10557.4 EFW99426.1 - 1.1e-24 86.0 0.0 2.7e-24 84.7 0.0 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain FATC PF02260.15 EFW99426.1 - 3.1e-07 29.7 0.2 9.5e-07 28.1 0.1 1.9 1 0 0 1 1 1 1 FATC domain Sugar_tr PF00083.19 EFW99427.1 - 9.3e-46 156.3 33.2 1.6e-44 152.2 23.0 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFW99427.1 - 2.7e-16 59.2 38.7 8.6e-09 34.5 9.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF606 PF04657.8 EFW99427.1 - 0.018 15.1 2.9 0.018 15.1 2.0 4.1 4 1 0 4 4 4 0 Protein of unknown function, DUF606 BT1 PF03092.11 EFW99427.1 - 0.027 13.1 6.6 0.27 9.8 4.6 2.2 1 1 0 1 1 1 0 BT1 family ABC_tran PF00005.22 EFW99428.1 - 7.3e-32 110.5 0.0 1.7e-31 109.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EFW99428.1 - 7.6e-15 55.0 10.9 1.3e-14 54.3 7.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 EFW99428.1 - 1.8e-06 27.3 0.0 1.8e-05 24.1 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFW99428.1 - 6.5e-06 26.3 0.9 0.0029 17.5 0.0 2.8 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EFW99428.1 - 0.00011 21.4 0.0 0.00033 19.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFW99428.1 - 0.0024 18.7 0.0 0.0078 17.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 EFW99428.1 - 0.0088 15.9 0.1 0.044 13.6 0.1 2.1 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.7 EFW99428.1 - 0.013 14.6 0.1 0.035 13.2 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.1 EFW99428.1 - 0.023 14.2 0.1 0.077 12.5 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1385 PF07136.6 EFW99428.1 - 0.04 12.9 2.7 1 8.3 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1385) AAA_16 PF13191.1 EFW99428.1 - 0.046 13.7 0.1 0.24 11.3 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 EFW99428.1 - 0.065 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Peptidase_M28 PF04389.12 EFW99429.1 - 4.9e-39 133.8 0.0 7.8e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 DUF3224 PF11528.3 EFW99430.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3224) G-patch PF01585.18 EFW99431.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 G-patch domain Amino_oxidase PF01593.19 EFW99432.1 - 3.8e-56 191.0 0.0 4.9e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFW99432.1 - 1.5e-09 37.7 0.0 3.7e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFW99432.1 - 0.00079 18.4 0.1 0.0016 17.4 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFW99432.1 - 0.00096 19.2 0.0 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFW99432.1 - 0.0058 15.5 0.0 0.0088 14.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 EFW99432.1 - 0.024 13.7 0.6 0.047 12.7 0.4 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.9 EFW99432.1 - 0.11 10.9 0.0 0.18 10.2 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein DUF4229 PF14012.1 EFW99433.1 - 0.033 14.0 0.2 0.15 11.9 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) APC_CDC26 PF10471.4 EFW99434.1 - 0.0012 19.5 15.1 0.0012 19.5 10.5 4.3 2 2 0 2 2 2 1 Anaphase-promoting complex APC subunit 1 DNA_pol_B PF00136.16 EFW99435.1 - 1.6e-145 485.4 4.1 2.4e-145 484.9 2.8 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EFW99435.1 - 2.8e-78 263.0 0.2 1e-77 261.1 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 EFW99435.1 - 1.7e-21 75.9 3.6 4.8e-21 74.5 2.5 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.1 EFW99435.1 - 0.0016 18.2 0.1 0.0069 16.2 0.1 2.2 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_2 PF03175.8 EFW99435.1 - 0.028 13.0 2.2 1.4 7.4 0.0 3.4 4 0 0 4 4 4 0 DNA polymerase type B, organellar and viral DUF2614 PF11023.3 EFW99435.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2614) C1_1 PF00130.17 EFW99435.1 - 2.9 7.6 8.6 2.4 7.9 0.3 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Metallophos PF00149.23 EFW99436.1 - 2.7e-06 26.9 0.6 1.1e-05 24.9 0.4 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Git3 PF11710.3 EFW99437.1 - 3.8e-17 62.5 11.2 1.7e-16 60.3 7.8 2.0 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 EFW99437.1 - 4.8e-09 35.7 7.1 7.2e-09 35.1 4.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3_C PF11970.3 EFW99437.1 - 1.2e-06 28.2 0.2 5.6e-06 26.0 0.1 2.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term TPR_1 PF00515.23 EFW99438.1 - 1.8e-07 30.4 4.3 0.036 13.6 0.4 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFW99438.1 - 2e-06 28.0 5.6 1.1 9.6 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFW99438.1 - 3.1e-06 26.7 10.3 0.00077 19.0 0.0 4.9 4 3 2 6 6 6 3 TPR repeat TPR_17 PF13431.1 EFW99438.1 - 5.7e-06 26.1 0.5 12 6.4 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFW99438.1 - 1.4e-05 24.5 7.5 0.00051 19.6 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EFW99438.1 - 2.5e-05 24.0 3.0 0.18 11.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFW99438.1 - 0.00074 20.1 17.6 1.4 9.6 0.2 5.9 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFW99438.1 - 0.0013 18.4 1.5 0.23 11.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFW99438.1 - 0.0018 18.7 13.5 19 6.2 0.0 5.9 4 3 3 7 7 7 0 Tetratricopeptide repeat DUF3856 PF12968.2 EFW99438.1 - 0.0052 16.6 0.5 0.022 14.5 0.1 2.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_5 PF12688.2 EFW99438.1 - 0.014 15.4 0.2 2.5 8.1 0.0 2.7 3 0 0 3 3 2 0 Tetratrico peptide repeat TPR_12 PF13424.1 EFW99438.1 - 0.017 15.0 16.3 0.2 11.6 0.0 4.9 5 2 1 6 6 6 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.11 EFW99438.1 - 0.019 14.7 0.4 1.5 8.6 0.0 3.0 3 0 0 3 3 3 0 Exonuclease VII small subunit Apc3 PF12895.2 EFW99438.1 - 0.027 14.6 2.8 1.2 9.3 0.0 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 EFW99438.1 - 0.043 13.7 19.4 0.16 11.9 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFW99438.1 - 0.067 13.6 0.5 0.067 13.6 0.3 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF4243 PF14027.1 EFW99439.1 - 5e-72 243.1 2.9 1e-71 242.1 2.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) DUF676 PF05057.9 EFW99439.1 - 0.00012 21.4 0.0 0.00019 20.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EFW99439.1 - 0.00039 20.0 0.0 0.00069 19.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 EFW99439.1 - 0.0038 16.9 0.0 0.0088 15.8 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.7 EFW99439.1 - 0.032 13.7 0.0 0.069 12.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Mito_carr PF00153.22 EFW99440.1 - 3.9e-51 170.7 6.0 2.5e-19 68.7 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.20 EFW99441.1 - 4.5e-17 62.0 0.0 6.8e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99441.1 - 3.3e-06 26.3 0.0 4.2e-05 22.7 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase zf-HC5HC2H_2 PF13832.1 EFW99442.1 - 1.5e-21 76.4 10.5 3.2e-19 68.9 0.1 3.8 3 0 0 3 3 3 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFW99442.1 - 5.6e-17 61.6 1.0 5.6e-17 61.6 0.7 4.5 5 0 0 5 5 5 1 PHD-like zinc-binding domain BAH PF01426.13 EFW99442.1 - 2.6e-14 52.9 0.1 6.2e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 BAH domain PHD PF00628.24 EFW99442.1 - 4.7e-12 45.3 52.4 1.9e-06 27.4 5.0 6.1 6 0 0 6 6 6 3 PHD-finger PHD_2 PF13831.1 EFW99442.1 - 1.4e-08 33.9 3.6 1.4e-08 33.9 2.5 4.9 5 0 0 5 5 5 2 PHD-finger FYVE_2 PF02318.11 EFW99442.1 - 0.0011 18.8 3.5 0.0011 18.8 2.4 3.8 5 0 0 5 5 5 1 FYVE-type zinc finger DUF2599 PF10783.4 EFW99442.1 - 0.0014 19.2 1.8 0.008 16.7 0.2 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2599) Prok-RING_1 PF14446.1 EFW99442.1 - 0.0017 18.0 36.5 0.0093 15.6 1.4 4.4 4 0 0 4 4 4 3 Prokaryotic RING finger family 1 C1_1 PF00130.17 EFW99442.1 - 0.0061 16.2 1.5 0.0061 16.2 1.0 5.2 5 1 0 5 5 5 3 Phorbol esters/diacylglycerol binding domain (C1 domain) SAS4 PF15460.1 EFW99443.1 - 4.2e-35 119.6 0.3 1e-34 118.3 0.2 1.7 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Adaptin_binding PF10199.4 EFW99443.1 - 0.5 10.6 11.0 0.017 15.3 2.6 2.3 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 WD40 PF00400.27 EFW99446.1 - 5.4e-23 79.9 9.3 5.1e-06 26.1 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 EFW99446.1 - 0.0011 17.2 0.9 0.0011 17.2 0.6 2.2 1 1 2 3 3 3 1 Nucleoporin Nup120/160 DUF726 PF05277.7 EFW99447.1 - 2.4e-127 424.5 1.8 3.8e-127 423.9 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Lipase_GDSL_2 PF13472.1 EFW99448.1 - 2.7e-25 89.5 0.0 3.5e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFW99448.1 - 1.5e-09 38.0 0.0 4.2e-09 36.5 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CUE PF02845.11 EFW99448.1 - 0.032 13.7 0.0 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 CUE domain Syntaxin-6_N PF09177.6 EFW99449.1 - 2.9e-22 78.8 0.0 2.3e-21 75.9 0.0 2.1 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 EFW99449.1 - 2.3e-12 46.4 4.7 2.3e-12 46.4 3.3 3.1 3 1 1 4 4 4 1 SNARE domain Myosin_tail_1 PF01576.14 EFW99449.1 - 0.0024 15.6 1.5 0.065 10.9 0.0 2.0 2 0 0 2 2 2 2 Myosin tail PilJ PF13675.1 EFW99449.1 - 0.039 14.2 2.4 0.23 11.8 0.0 2.3 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF745 PF05335.8 EFW99449.1 - 0.17 11.3 1.1 0.56 9.7 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DegS PF05384.6 EFW99449.1 - 0.19 10.9 3.8 0.084 12.0 0.5 2.0 3 0 0 3 3 3 0 Sensor protein DegS Arrestin_C PF02752.17 EFW99450.1 - 2e-11 44.1 0.5 2.6e-09 37.3 0.4 3.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain MFS_1 PF07690.11 EFW99451.1 - 4.1e-14 52.0 51.8 2.2e-12 46.3 10.4 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily Ribosomal_60s PF00428.14 EFW99452.1 - 4.1e-27 94.4 12.5 4.7e-27 94.2 8.7 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Carb_kinase PF01256.12 EFW99453.1 - 1.1e-51 175.5 0.2 2e-51 174.6 0.1 1.5 1 1 0 1 1 1 1 Carbohydrate kinase HK PF02110.10 EFW99453.1 - 0.0007 18.8 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family RNA_pol_Rpb1_1 PF04997.7 EFW99454.1 - 5.8e-111 370.9 0.0 1.1e-110 370.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 EFW99454.1 - 2.3e-101 338.7 0.2 5.1e-101 337.5 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EFW99454.1 - 2.8e-70 235.5 0.0 6.9e-70 234.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 EFW99454.1 - 7.1e-51 172.6 2.7 1.6e-50 171.5 1.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 EFW99454.1 - 3.6e-45 153.5 0.0 7.9e-45 152.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 EFW99454.1 - 1e-40 138.5 4.1 8.5e-40 135.5 3.6 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 EFW99454.1 - 3.3e-36 123.2 0.1 7.9e-36 122.0 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 EFW99454.1 - 9 6.7 182.6 0.1 12.7 6.0 12.9 7 3 7 15 15 15 0 RNA polymerase Rpb1 C-terminal repeat AA_permease_2 PF13520.1 EFW99455.1 - 8.2e-39 133.3 55.8 1.1e-38 132.9 38.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFW99455.1 - 1.5e-17 63.1 47.0 2e-17 62.6 32.6 1.1 1 0 0 1 1 1 1 Amino acid permease CH PF00307.26 EFW99457.1 - 6.4e-10 39.0 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF3439 PF11921.3 EFW99457.1 - 0.012 15.4 3.7 0.03 14.0 2.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF155 PF02582.9 EFW99458.1 - 2.6e-53 180.4 0.3 4.2e-53 179.8 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 ABC_membrane_2 PF06472.10 EFW99459.1 - 1.8e-102 342.3 0.4 2.8e-102 341.6 0.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EFW99459.1 - 1.5e-17 64.1 0.0 4.5e-17 62.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 EFW99459.1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFW99459.1 - 0.02 14.8 0.0 0.061 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 EFW99459.1 - 0.062 12.8 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.14 EFW99459.1 - 0.12 11.6 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFW99459.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thg1 PF04446.7 EFW99460.1 - 2.5e-47 159.8 0.0 3.7e-47 159.3 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.1 EFW99460.1 - 9.8e-38 128.5 0.0 1.4e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain Ribophorin_II PF05817.9 EFW99461.1 - 1.4e-23 83.0 0.6 4.1e-23 81.4 0.4 1.6 1 1 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II UCR_6-4kD PF08997.5 EFW99461.1 - 0.14 11.9 0.2 0.29 10.8 0.1 1.6 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Zn_clus PF00172.13 EFW99462.1 - 2.3e-08 33.8 12.0 4.3e-08 32.9 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFW99462.1 - 0.0004 19.1 1.8 0.00076 18.1 0.7 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain GlcNAc_2-epim PF07221.6 EFW99462.1 - 0.0085 15.1 0.6 0.44 9.5 0.1 2.3 2 0 0 2 2 2 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) DUF2175 PF09943.4 EFW99463.1 - 0.15 12.1 0.0 0.49 10.4 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) PH PF00169.24 EFW99464.1 - 2.8e-05 24.2 0.0 0.00019 21.5 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_9 PF15410.1 EFW99464.1 - 0.016 15.3 0.0 0.044 13.9 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3328 PF11807.3 EFW99466.1 - 7.6e-25 87.8 2.1 1.2e-24 87.2 1.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) GCV_T PF01571.16 EFW99467.1 - 2e-59 200.5 0.0 2.7e-59 200.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 EFW99467.1 - 3.2e-22 78.3 0.4 6.5e-22 77.3 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain DUF3659 PF12396.3 EFW99467.1 - 0.0065 16.1 0.1 0.024 14.3 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3659) Ribosomal_L10 PF00466.15 EFW99468.1 - 2.9e-16 59.1 0.0 5.4e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Tenui_NCP PF04876.7 EFW99468.1 - 0.17 11.4 0.1 0.26 10.8 0.1 1.2 1 0 0 1 1 1 0 Tenuivirus major non-capsid protein Fungal_trans PF04082.13 EFW99469.1 - 1.2e-07 30.9 0.1 2.2e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFW99469.1 - 5.9e-06 26.0 13.9 5.9e-06 26.0 9.7 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_22 PF13401.1 EFW99470.1 - 0.0012 19.0 0.0 0.0053 16.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFW99470.1 - 0.0052 16.7 0.0 0.012 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EFW99470.1 - 0.018 14.8 0.0 0.051 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFW99470.1 - 0.048 14.4 0.1 0.28 11.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain FAM212 PF15342.1 EFW99470.1 - 0.072 12.7 0.2 5.1 6.7 0.0 2.7 2 0 0 2 2 2 0 FAM212 family AAA_28 PF13521.1 EFW99470.1 - 0.081 12.8 0.1 0.24 11.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFW99470.1 - 0.11 11.9 0.1 0.31 10.4 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain ABC_tran PF00005.22 EFW99470.1 - 0.18 12.1 0.0 0.46 10.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Cerato-platanin PF07249.7 EFW99471.1 - 4.8e-58 194.3 5.7 5.5e-58 194.1 4.0 1.0 1 0 0 1 1 1 1 Cerato-platanin Arf PF00025.16 EFW99472.1 - 2e-15 56.4 0.0 8.8e-15 54.3 0.0 1.9 1 1 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.17 EFW99472.1 - 0.00044 19.6 0.0 0.00081 18.8 0.0 1.4 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 EFW99472.1 - 0.0098 15.0 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.22 EFW99472.1 - 0.02 15.1 0.0 0.051 13.8 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Miro PF08477.8 EFW99472.1 - 0.029 14.8 0.0 0.051 14.0 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein cobW PF02492.14 EFW99472.1 - 0.1 12.0 0.1 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IF-2B PF01008.12 EFW99473.1 - 1.7e-35 122.4 0.0 2.8e-35 121.6 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family FA_desaturase PF00487.19 EFW99474.1 - 2e-20 73.3 11.5 2.3e-20 73.1 8.0 1.1 1 0 0 1 1 1 1 Fatty acid desaturase DUF2360 PF10152.4 EFW99475.1 - 0.13 12.5 4.6 0.064 13.5 1.1 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) CENP-B_dimeris PF09026.5 EFW99475.1 - 6.4 7.0 18.4 0.27 11.4 6.0 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Pneumo_phosprot PF02478.11 EFW99476.1 - 8.7 5.7 8.1 0.23 10.9 0.7 1.8 2 1 0 2 2 2 0 Pneumovirus phosphoprotein p450 PF00067.17 EFW99477.1 - 6.8e-48 163.3 0.0 7.7e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Yos1 PF08571.5 EFW99479.1 - 3.8e-31 107.0 1.0 4.2e-31 106.8 0.7 1.0 1 0 0 1 1 1 1 Yos1-like Tim44 PF04280.10 EFW99480.1 - 4.9e-34 117.4 1.1 7e-34 116.9 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain CDC45 PF02724.9 EFW99480.1 - 0.044 11.8 14.5 0.058 11.4 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Ebola_NP PF05505.7 EFW99480.1 - 8.4 4.3 15.6 12 3.7 10.8 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Med14 PF08638.6 EFW99481.1 - 3.1e-64 215.8 0.0 6e-64 214.8 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 AAA PF00004.24 EFW99482.1 - 1.2e-42 145.2 0.0 2.2e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFW99482.1 - 6.4e-08 32.7 0.0 4.6e-06 26.7 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 EFW99482.1 - 1.6e-06 27.9 0.1 3.7e-05 23.4 0.0 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFW99482.1 - 1.9e-06 27.8 0.0 7.6e-06 25.9 0.0 2.0 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EFW99482.1 - 2.8e-06 27.4 0.0 0.001 19.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 EFW99482.1 - 7.2e-06 25.2 0.0 1.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 EFW99482.1 - 0.00022 20.2 0.0 0.00049 19.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 EFW99482.1 - 0.00032 20.3 0.0 0.00075 19.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 EFW99482.1 - 0.00032 20.9 0.2 0.0082 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFW99482.1 - 0.00059 20.6 0.5 0.0019 19.0 0.1 2.3 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.1 EFW99482.1 - 0.0013 18.6 0.0 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFW99482.1 - 0.0017 18.2 0.0 0.0061 16.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 EFW99482.1 - 0.0017 17.1 0.0 0.0031 16.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 EFW99482.1 - 0.0026 17.1 0.0 0.0053 16.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 EFW99482.1 - 0.0035 16.5 0.0 0.0065 15.6 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EFW99482.1 - 0.0049 17.0 0.0 0.0096 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Zeta_toxin PF06414.7 EFW99482.1 - 0.005 15.9 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Sigma54_activat PF00158.21 EFW99482.1 - 0.0072 15.8 0.0 0.025 14.0 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_25 PF13481.1 EFW99482.1 - 0.0084 15.5 0.1 0.046 13.1 0.1 2.1 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.6 EFW99482.1 - 0.0088 15.6 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 EFW99482.1 - 0.017 14.7 0.2 0.24 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EFW99482.1 - 0.019 14.5 0.1 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFW99482.1 - 0.023 14.6 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 EFW99482.1 - 0.023 14.5 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.1 EFW99482.1 - 0.024 14.7 0.0 0.063 13.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain KaiC PF06745.8 EFW99482.1 - 0.025 13.6 0.0 0.097 11.7 0.0 2.0 2 0 0 2 2 2 0 KaiC Arch_ATPase PF01637.13 EFW99482.1 - 0.026 14.2 0.0 0.15 11.7 0.0 2.2 1 1 0 1 1 1 0 Archaeal ATPase Thymidylate_kin PF02223.12 EFW99482.1 - 0.028 13.7 0.0 1.4 8.2 0.0 2.6 3 0 0 3 3 2 0 Thymidylate kinase PhoH PF02562.11 EFW99482.1 - 0.031 13.5 0.0 0.056 12.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.7 EFW99482.1 - 0.039 13.6 0.0 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain UPF0079 PF02367.12 EFW99482.1 - 0.048 13.2 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 EFW99482.1 - 0.079 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 EFW99482.1 - 0.1 11.4 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DAP3 PF10236.4 EFW99482.1 - 0.12 11.3 0.1 1.1 8.1 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.1 EFW99482.1 - 0.37 11.1 6.0 4.8 7.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF4200 PF13863.1 EFW99482.1 - 0.86 9.5 5.9 0.12 12.3 1.0 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) HSP70 PF00012.15 EFW99483.1 - 9e-08 30.4 0.1 7.4e-06 24.1 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein HCNGP PF07818.8 EFW99484.1 - 2.1e-16 59.7 0.0 3.5e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 HCNGP-like protein Pkinase PF00069.20 EFW99485.1 - 2.8e-34 118.4 0.0 9.1e-20 70.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99485.1 - 1.8e-10 40.3 0.0 8.7e-06 24.9 0.0 3.1 2 2 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 EFW99485.1 - 8.1e-06 25.7 0.1 0.00015 21.5 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EFW99485.1 - 0.0071 15.3 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Tim17 PF02466.14 EFW99486.1 - 9.2e-22 77.4 0.0 1.6e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family FMN_dh PF01070.13 EFW99487.1 - 3.6e-98 328.7 0.2 4.5e-98 328.3 0.2 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EFW99487.1 - 3.4e-22 78.0 0.0 7.5e-22 76.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.20 EFW99487.1 - 7.9e-06 24.9 0.0 0.002 17.0 0.0 2.7 3 0 0 3 3 3 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 EFW99487.1 - 2.6e-05 23.3 0.0 2.6e-05 23.3 0.0 1.5 2 0 0 2 2 2 1 Conserved region in glutamate synthase Ribosomal_S17 PF00366.15 EFW99488.1 - 2.1e-29 101.3 0.3 3.2e-29 100.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 G6PD_C PF02781.11 EFW99489.1 - 1.4e-131 437.6 0.0 1.9e-131 437.2 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 EFW99489.1 - 1.5e-62 211.0 0.0 2.3e-62 210.4 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain CZB PF13682.1 EFW99489.1 - 0.011 15.8 0.1 0.024 14.7 0.0 1.6 1 0 0 1 1 1 0 Chemoreceptor zinc-binding domain ATP-synt_E PF05680.7 EFW99490.1 - 7e-25 86.8 0.2 7.5e-25 86.7 0.1 1.1 1 0 0 1 1 1 1 ATP synthase E chain EFhand_Ca_insen PF08726.5 EFW99490.1 - 0.022 14.7 0.1 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Ca2+ insensitive EF hand DUF349 PF03993.7 EFW99490.1 - 0.04 14.0 0.2 0.056 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) MMS19_N PF14500.1 EFW99491.1 - 2.1e-32 112.4 0.4 1.7e-30 106.2 0.1 3.3 2 1 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.3 EFW99491.1 - 3.4e-17 62.2 0.4 6.6e-17 61.3 0.3 1.4 1 0 0 1 1 1 1 RNAPII transcription regulator C-terminal NRN1 PF15056.1 EFW99491.1 - 0.19 11.6 0.0 2.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Neuritin protein family Peptidase_A4 PF01828.12 EFW99492.1 - 3e-53 179.9 9.2 5e-53 179.2 6.4 1.3 1 0 0 1 1 1 1 Peptidase A4 family TPR_1 PF00515.23 EFW99493.1 - 2.3e-23 80.7 4.1 5e-07 29.0 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.12 EFW99493.1 - 3.1e-22 76.6 10.0 3.6e-06 26.4 0.1 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 EFW99493.1 - 5.1e-22 77.2 10.2 1.1e-11 44.2 0.9 4.3 3 1 1 4 4 4 4 TPR repeat TPR_14 PF13428.1 EFW99493.1 - 1.6e-18 65.5 9.8 2.3e-06 27.7 0.1 6.5 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFW99493.1 - 3.2e-15 56.2 7.0 1e-05 25.7 0.0 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 EFW99493.1 - 7.6e-15 54.6 7.6 2.8e-07 30.3 0.9 3.7 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 EFW99493.1 - 2.6e-14 53.4 17.1 6.9e-08 32.9 0.2 4.4 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFW99493.1 - 8.8e-14 50.1 4.7 0.0083 15.8 0.0 6.0 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 EFW99493.1 - 1.4e-13 49.8 9.2 0.00093 19.2 0.0 5.8 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFW99493.1 - 1.5e-10 40.0 6.5 0.0025 17.4 0.0 5.4 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.1 EFW99493.1 - 3.2e-09 36.5 3.1 0.00038 20.2 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.1 EFW99493.1 - 8e-09 35.5 8.4 0.00024 21.1 0.0 4.2 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 EFW99493.1 - 1.2e-07 31.7 2.3 0.19 12.2 0.0 5.7 5 1 0 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 EFW99493.1 - 9.2e-07 28.9 4.3 0.00038 20.5 0.2 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 EFW99493.1 - 0.00019 20.6 2.3 0.18 10.7 0.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 EFW99493.1 - 0.0028 17.5 6.7 2 8.4 0.2 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat CRISPR_Cse2 PF09485.5 EFW99493.1 - 0.011 15.7 1.6 0.022 14.8 0.2 2.2 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) TPR_3 PF07720.7 EFW99493.1 - 0.14 12.0 1.3 42 4.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribul_P_3_epim PF00834.14 EFW99494.1 - 5.5e-64 214.9 0.0 3.9e-63 212.1 0.0 1.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.9 EFW99494.1 - 0.0064 15.5 1.1 0.0086 15.1 0.8 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG Bac_luciferase PF00296.15 EFW99494.1 - 0.034 13.2 0.9 0.034 13.2 0.6 1.5 2 0 0 2 2 2 0 Luciferase-like monooxygenase OMPdecase PF00215.19 EFW99494.1 - 0.063 12.6 0.3 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Dmrt1 PF12374.3 EFW99494.1 - 0.13 12.5 0.1 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 DUF1403 PF07183.6 EFW99495.1 - 0.017 14.5 0.3 0.022 14.1 0.2 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1403) DUF3418 PF11898.3 EFW99495.1 - 0.064 11.6 0.4 0.066 11.6 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) SERTA PF06031.8 EFW99495.1 - 0.14 11.4 0.1 0.26 10.6 0.1 1.4 1 0 0 1 1 1 0 SERTA motif tRNA_int_end_N2 PF12928.2 EFW99496.1 - 1.8e-12 46.5 3.1 4.4e-12 45.2 2.2 1.6 1 1 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Yae1_N PF09811.4 EFW99497.1 - 9.9e-11 40.9 5.0 2e-10 40.0 3.5 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal CR6_interact PF10147.4 EFW99497.1 - 0.004 16.5 2.3 0.0069 15.7 1.6 1.3 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF1690 PF07956.6 EFW99497.1 - 1.1 9.1 4.9 1.9 8.4 3.4 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF1675 PF07897.6 EFW99497.1 - 3.1 7.5 15.5 20 4.9 10.2 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1675) Stm1_N PF09598.5 EFW99498.1 - 0.31 11.7 5.4 0.58 10.9 1.9 3.1 2 0 0 2 2 2 0 Stm1 UQ_con PF00179.21 EFW99499.1 - 1.8e-36 124.6 0.0 2.8e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EFW99499.1 - 0.0083 16.0 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 EFW99499.1 - 0.03 14.0 0.1 0.13 12.0 0.0 2.1 2 1 0 2 2 2 0 Prokaryotic E2 family B Cortexin PF11057.3 EFW99500.1 - 0.067 12.7 0.3 0.16 11.6 0.2 1.6 1 0 0 1 1 1 0 Cortexin of kidney Fmp27_WPPW PF10359.4 EFW99500.1 - 0.38 9.1 0.1 0.57 8.5 0.0 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Ycf9 PF01737.12 EFW99500.1 - 2.4 7.6 9.2 0.11 11.9 0.1 3.2 3 1 0 3 3 3 0 YCF9 CarbpepA_inh PF02977.10 EFW99502.1 - 1.2 8.7 14.4 0.58 9.7 0.3 3.4 3 0 0 3 3 3 0 Carboxypeptidase A inhibitor SIMPL PF04402.9 EFW99502.1 - 1.2 8.9 6.6 0.31 10.8 0.7 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF541) DUF2580 PF10824.3 EFW99502.1 - 1.7 9.0 11.5 7.5 6.9 2.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2580) TIM PF00121.13 EFW99503.1 - 7.4e-87 290.4 0.1 8.3e-87 290.2 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase zf-ZPR1 PF03367.8 EFW99504.1 - 4.4e-102 338.0 0.1 9.3e-52 174.4 0.0 3.1 2 1 0 2 2 2 2 ZPR1 zinc-finger domain UPF0547 PF10571.4 EFW99504.1 - 3.2 7.5 6.7 8.3 6.2 0.0 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 RNB PF00773.14 EFW99505.1 - 2.8e-75 253.6 0.0 2.8e-75 253.6 0.0 3.1 3 0 0 3 3 3 1 RNB domain Ycf1 PF05758.7 EFW99505.1 - 0.0013 16.6 8.2 0.0024 15.6 5.7 1.5 1 0 0 1 1 1 1 Ycf1 Spore_coat_CotO PF14153.1 EFW99505.1 - 0.0052 16.2 19.1 0.0052 16.2 13.3 3.3 3 0 0 3 3 3 1 Spore coat protein CotO DUF4239 PF14023.1 EFW99505.1 - 0.091 12.1 0.1 0.091 12.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) Neur_chan_memb PF02932.11 EFW99505.1 - 2.9 7.7 19.6 1.8 8.4 7.0 3.4 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.5 EFW99505.1 - 5.1 5.3 14.2 7.9 4.7 9.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ribosomal_L35Ae PF01247.13 EFW99506.1 - 9.6e-42 140.6 1.1 1.1e-41 140.5 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 EFW99506.1 - 7.6e-06 25.7 0.2 0.019 14.8 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain Big_4 PF07532.6 EFW99506.1 - 0.072 12.6 0.0 0.099 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) WW PF00397.21 EFW99507.1 - 7.4e-08 32.1 0.1 1.5e-07 31.1 0.1 1.5 1 0 0 1 1 1 1 WW domain FMO-like PF00743.14 EFW99508.1 - 7.7e-28 96.9 0.0 5.1e-14 51.3 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFW99508.1 - 2.3e-17 63.7 0.1 1e-16 61.6 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFW99508.1 - 1.7e-07 30.4 0.1 4.7e-06 25.7 0.0 2.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFW99508.1 - 2e-06 27.8 0.1 0.022 14.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFW99508.1 - 0.0019 17.9 0.1 0.12 12.1 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFW99508.1 - 0.011 15.7 0.0 0.034 14.1 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RRM_1 PF00076.17 EFW99509.1 - 6.7e-13 48.0 0.0 1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99509.1 - 2.3e-09 37.1 0.0 3.6e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99509.1 - 9.7e-08 31.7 0.0 1.5e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HET PF06985.6 EFW99510.1 - 2.1e-21 76.5 4.9 3.9e-20 72.4 3.4 2.3 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Podoplanin PF05808.6 EFW99511.1 - 5.4e-05 22.8 0.4 5.4e-05 22.8 0.3 2.1 2 1 0 2 2 2 1 Podoplanin VSP PF03302.8 EFW99511.1 - 0.0012 17.5 0.2 0.002 16.8 0.1 1.3 1 0 0 1 1 1 1 Giardia variant-specific surface protein SKG6 PF08693.5 EFW99511.1 - 0.008 15.4 1.9 0.008 15.4 1.3 2.8 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.10 EFW99511.1 - 0.0086 15.6 0.6 0.021 14.3 0.4 1.6 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 DUF1180 PF06679.7 EFW99511.1 - 0.021 14.7 0.9 0.087 12.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Mid2 PF04478.7 EFW99511.1 - 0.031 13.6 0.1 0.056 12.8 0.1 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Rifin_STEVOR PF02009.11 EFW99511.1 - 0.045 13.3 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 Rifin/stevor family Amnionless PF14828.1 EFW99511.1 - 0.19 10.1 0.1 0.27 9.6 0.0 1.1 1 0 0 1 1 1 0 Amnionless Methyltransf_11 PF08241.7 EFW99512.1 - 6.1e-06 26.6 0.0 9.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99512.1 - 3.1e-05 24.5 0.0 4.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW99512.1 - 3.4e-05 23.4 0.0 4.8e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW99512.1 - 0.00016 21.7 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW99512.1 - 0.00044 20.5 0.0 0.00086 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99512.1 - 0.0013 19.2 0.0 0.0025 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFW99512.1 - 0.073 12.7 0.3 0.45 10.2 0.1 2.2 1 1 1 2 2 2 0 Methyltransferase domain SET PF00856.23 EFW99513.1 - 4.9e-11 43.1 0.0 5.7e-10 39.7 0.0 2.3 1 1 0 1 1 1 1 SET domain Epimerase PF01370.16 EFW99514.1 - 5e-20 71.9 0.0 7.2e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EFW99514.1 - 1.2e-07 30.9 0.1 2.9e-07 29.6 0.1 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 EFW99514.1 - 4.7e-05 23.3 0.0 0.00026 20.9 0.0 2.2 3 0 0 3 3 3 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EFW99514.1 - 0.00045 20.2 0.1 0.0029 17.6 0.1 2.1 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFW99514.1 - 0.0011 17.7 0.0 0.0027 16.4 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFW99514.1 - 0.0028 16.6 0.0 0.0056 15.6 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein KR PF08659.5 EFW99514.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 KR domain Saccharop_dh PF03435.13 EFW99514.1 - 0.074 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase IQ PF00612.22 EFW99515.1 - 2.8e-06 26.4 2.7 1.1e-05 24.6 1.8 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lyase_1 PF00206.15 EFW99516.1 - 5.3e-18 65.2 0.2 1e-17 64.2 0.1 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 EFW99516.1 - 8.7e-10 38.4 0.0 2.5e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus PIP5K PF01504.13 EFW99517.1 - 1.7e-59 200.9 0.3 3.1e-59 200.1 0.2 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 EFW99517.1 - 1.3e-24 86.7 0.0 2.2e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 EFW99517.1 - 7.1e-13 48.2 7.3 1.6e-12 47.1 5.0 1.6 1 0 0 1 1 1 1 FYVE zinc finger DUF2404 PF10296.4 EFW99517.1 - 0.0094 16.0 0.0 0.034 14.2 0.0 1.9 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) DUF2470 PF10615.4 EFW99518.1 - 2.4e-13 50.1 0.1 3.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Guanylate_kin PF00625.16 EFW99518.1 - 0.035 13.5 0.0 0.051 13.0 0.0 1.1 1 0 0 1 1 1 0 Guanylate kinase ADK PF00406.17 EFW99519.1 - 9.3e-35 119.7 0.0 9.5e-21 74.2 0.0 2.1 1 1 1 2 2 2 2 Adenylate kinase ADK_lid PF05191.9 EFW99519.1 - 5.7e-12 45.0 0.0 1e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.1 EFW99519.1 - 9.3e-07 29.2 0.0 0.0035 17.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EFW99519.1 - 2.4e-05 25.1 0.0 7.1e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFW99519.1 - 0.00073 19.4 0.0 0.0046 16.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFW99519.1 - 0.045 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CDP-OH_P_transf PF01066.16 EFW99521.1 - 8.3e-17 61.3 3.4 8.3e-17 61.3 2.4 2.7 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase p450 PF00067.17 EFW99522.1 - 1.5e-42 145.6 0.0 2.1e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HpcH_HpaI PF03328.9 EFW99524.1 - 1.2e-28 99.4 0.0 9.4e-28 96.5 0.0 2.2 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 EFW99524.1 - 5.3e-10 38.6 0.0 0.00034 19.5 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold BolA PF01722.13 EFW99525.1 - 1.3e-25 89.1 0.2 1.7e-25 88.7 0.1 1.1 1 0 0 1 1 1 1 BolA-like protein DUF846 PF05832.7 EFW99526.1 - 5.6e-51 171.9 3.6 6.8e-51 171.7 2.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) VMA21 PF09446.5 EFW99527.1 - 4.1e-14 52.2 6.6 5.8e-14 51.7 4.6 1.2 1 0 0 1 1 1 1 VMA21-like domain DUF3611 PF12263.3 EFW99527.1 - 0.092 12.1 0.1 0.24 10.7 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3611) Bacillus_HBL PF05791.6 EFW99528.1 - 1.7e-05 24.3 2.9 0.012 15.0 0.5 2.3 1 1 1 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) Yippee-Mis18 PF03226.9 EFW99528.1 - 0.00013 21.9 1.2 0.00033 20.6 0.8 1.6 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Filament PF00038.16 EFW99528.1 - 0.00024 20.6 2.4 0.00024 20.6 1.7 2.7 2 1 2 4 4 3 2 Intermediate filament protein DUF1664 PF07889.7 EFW99528.1 - 0.00035 20.3 4.7 0.0037 17.0 0.8 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) GAS PF13851.1 EFW99528.1 - 0.0021 17.2 2.1 0.0053 15.9 1.5 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding WEMBL PF05701.6 EFW99528.1 - 0.0033 15.9 1.4 0.0033 15.9 1.0 2.0 1 1 0 2 2 2 1 Weak chloroplast movement under blue light Reo_sigmaC PF04582.7 EFW99528.1 - 0.0033 16.6 2.7 0.073 12.2 1.5 2.0 1 1 1 2 2 2 1 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 EFW99528.1 - 0.004 16.9 0.3 1.5 8.6 0.3 2.9 2 1 1 3 3 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_II PF06009.7 EFW99528.1 - 0.005 16.6 1.2 0.018 14.7 0.5 1.9 1 1 0 1 1 1 1 Laminin Domain II Spectrin PF00435.16 EFW99528.1 - 0.0053 17.0 1.0 0.0053 17.0 0.7 3.2 2 1 0 3 3 3 1 Spectrin repeat THOC7 PF05615.8 EFW99528.1 - 0.061 13.6 2.0 0.19 11.9 0.5 2.3 1 1 1 2 2 2 0 Tho complex subunit 7 Syntaxin-6_N PF09177.6 EFW99528.1 - 0.083 13.3 1.6 0.45 10.9 1.1 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal NPV_P10 PF05531.7 EFW99528.1 - 0.15 12.3 3.5 14 5.9 0.2 3.5 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein TBPIP PF07106.8 EFW99528.1 - 0.15 11.5 8.1 0.023 14.2 1.0 2.6 2 1 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Helitron_like_N PF14214.1 EFW99528.1 - 0.23 11.1 1.3 0.37 10.4 0.2 1.8 2 0 0 2 2 2 0 Helitron helicase-like domain at N-terminus YlqD PF11068.3 EFW99528.1 - 0.28 11.1 9.1 4.7 7.2 2.7 3.2 1 1 2 3 3 3 0 YlqD protein Tropomyosin PF00261.15 EFW99528.1 - 0.44 9.5 5.4 0.21 10.6 0.1 2.5 2 1 0 2 2 2 0 Tropomyosin Seryl_tRNA_N PF02403.17 EFW99528.1 - 0.5 10.3 3.1 2.3 8.2 0.7 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Prefoldin_2 PF01920.15 EFW99528.1 - 0.59 9.9 5.9 5.3 6.8 0.3 3.7 1 1 0 3 3 3 0 Prefoldin subunit COG2 PF06148.6 EFW99528.1 - 0.73 9.7 3.0 24 4.8 2.0 2.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4200 PF13863.1 EFW99528.1 - 0.87 9.5 6.2 23 4.9 1.2 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) HrpB7 PF09486.5 EFW99528.1 - 0.92 9.4 8.0 0.93 9.4 3.5 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Lectin_N PF03954.9 EFW99528.1 - 1.1 8.6 11.0 1.6 8.1 0.1 2.8 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain CENP-F_leu_zip PF10473.4 EFW99528.1 - 1.5 8.6 11.7 0.16 11.8 1.2 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.7 EFW99528.1 - 1.5 9.2 15.2 21 5.5 0.2 4.8 3 1 2 5 5 4 0 SlyX Atg14 PF10186.4 EFW99528.1 - 2.3 7.0 7.4 12 4.7 5.2 2.0 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TMF_TATA_bd PF12325.3 EFW99528.1 - 2.4 7.9 13.1 3 7.5 0.0 3.9 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.5 EFW99528.1 - 3.8 7.6 7.9 0.73 9.9 0.7 2.8 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Med9 PF07544.8 EFW99528.1 - 4.1 7.2 7.6 0.54 10.0 1.4 2.4 3 1 1 4 4 2 0 RNA polymerase II transcription mediator complex subunit 9 Mnd1 PF03962.10 EFW99528.1 - 5.2 6.6 10.2 0.24 11.0 2.0 2.3 2 1 1 3 3 3 0 Mnd1 family IncA PF04156.9 EFW99528.1 - 8.2 5.9 12.5 96 2.4 8.7 2.5 1 1 0 1 1 1 0 IncA protein WXG100 PF06013.7 EFW99528.1 - 8.5 6.4 8.7 8.8 6.4 1.8 3.1 2 1 1 3 3 2 0 Proteins of 100 residues with WXG Dynamitin PF04912.9 EFW99529.1 - 1.3e-28 99.8 1.0 4.6e-14 52.0 0.9 3.0 2 1 0 2 2 2 2 Dynamitin Tropomyosin_1 PF12718.2 EFW99529.1 - 0.02 14.7 14.1 0.067 13.0 3.1 3.3 3 0 0 3 3 3 0 Tropomyosin like Phage_GP20 PF06810.6 EFW99529.1 - 0.09 12.2 5.9 0.061 12.7 1.2 2.4 3 0 0 3 3 3 0 Phage minor structural protein GP20 BLOC1_2 PF10046.4 EFW99529.1 - 0.18 11.9 2.8 3.7 7.7 0.0 3.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATP-synt_E PF05680.7 EFW99529.1 - 0.27 11.2 7.9 0.13 12.2 2.5 2.4 2 0 0 2 2 2 0 ATP synthase E chain GrpE PF01025.14 EFW99529.1 - 0.33 10.4 6.7 0.82 9.2 2.6 2.6 2 1 0 2 2 2 0 GrpE DivIC PF04977.10 EFW99529.1 - 0.36 10.3 12.7 0.34 10.4 0.2 3.4 3 0 0 3 3 3 0 Septum formation initiator FH2 PF02181.18 EFW99529.1 - 0.41 9.4 2.0 15 4.2 0.0 2.9 3 0 0 3 3 3 0 Formin Homology 2 Domain FimP PF09766.4 EFW99529.1 - 0.43 9.5 2.5 0.74 8.8 1.8 1.3 1 0 0 1 1 1 0 Fms-interacting protein DUF1127 PF06568.6 EFW99529.1 - 1 8.8 11.1 0.53 9.7 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1127) Lebercilin PF15619.1 EFW99529.1 - 1.4 8.2 9.9 0.073 12.4 2.4 2.1 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4446 PF14584.1 EFW99529.1 - 1.7 8.4 4.1 5 6.9 0.9 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) CENP-F_leu_zip PF10473.4 EFW99529.1 - 4.5 7.1 10.5 0.4 10.5 2.4 2.5 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.3 EFW99529.1 - 8.1 6.3 13.5 0.37 10.6 2.3 2.9 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Ribosomal_S8 PF00410.14 EFW99530.1 - 1.4e-26 92.8 0.0 2e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 PP2C PF00481.16 EFW99531.1 - 4.9e-57 193.2 0.0 1e-56 192.1 0.0 1.6 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_4 PF12799.2 EFW99531.1 - 1.5e-49 164.9 64.3 2.5e-06 26.9 0.7 12.8 9 3 4 13 13 13 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFW99531.1 - 1.3e-35 120.9 53.9 6.3e-07 29.0 0.2 9.8 4 3 7 11 11 11 11 Leucine rich repeat Guanylate_cyc PF00211.15 EFW99531.1 - 2e-28 98.9 0.0 1.4e-27 96.3 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 EFW99531.1 - 1.7e-18 63.8 64.5 0.31 11.2 0.0 20.9 20 2 0 20 20 20 6 Leucine Rich Repeat LRR_7 PF13504.1 EFW99531.1 - 1.8e-13 48.3 46.9 0.51 10.7 0.1 17.8 18 0 0 18 18 18 4 Leucine rich repeat Ad_cyc_g-alpha PF08509.6 EFW99531.1 - 4.8e-13 48.2 0.1 1.3e-12 46.8 0.1 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_9 PF14580.1 EFW99531.1 - 0.0035 16.9 12.2 0.57 9.7 0.5 3.9 3 1 1 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.1 EFW99531.1 - 0.0041 17.0 47.6 9.7 6.6 0.1 16.1 16 2 3 19 19 19 2 Leucine Rich repeat Ribosomal_L10 PF00466.15 EFW99532.1 - 2.7e-25 88.2 0.1 6.9e-25 86.8 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 EFW99532.1 - 1e-16 61.0 8.5 1.1e-16 60.9 3.6 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein TSP9 PF11493.3 EFW99532.1 - 0.019 15.4 1.5 0.043 14.3 1.0 1.6 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 Val_tRNA-synt_C PF10458.4 EFW99532.1 - 0.53 10.4 4.9 1.2 9.2 3.4 1.5 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm ATP-synt_ab PF00006.20 EFW99533.1 - 3.8e-23 82.1 0.0 6e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.18 EFW99533.1 - 8.9e-16 57.8 2.8 1.8e-15 56.8 2.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 EFW99533.1 - 0.0014 18.5 0.7 0.0049 16.7 0.4 2.0 2 1 0 2 2 2 1 HAS barrel domain AAA_25 PF13481.1 EFW99533.1 - 0.08 12.3 0.1 0.19 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain RbcS PF12338.3 EFW99533.1 - 0.89 9.3 4.9 33 4.3 0.1 3.2 3 0 0 3 3 3 0 Ribulose-1,5-bisphosphate carboxylase small subunit PKD_channel PF08016.7 EFW99534.1 - 0.079 11.3 8.6 0.28 9.5 0.6 2.2 2 0 0 2 2 2 0 Polycystin cation channel LETM1 PF07766.8 EFW99535.1 - 5e-109 363.4 1.0 6.9e-109 363.0 0.7 1.2 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.22 EFW99535.1 - 6.9e-06 25.4 0.2 0.0088 15.5 0.0 3.6 4 0 0 4 4 4 2 SAP domain DEAD PF00270.24 EFW99536.1 - 1.4e-11 44.2 0.0 6.6e-11 41.9 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99536.1 - 8.8e-09 35.1 0.0 2.4e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 EFW99536.1 - 0.0018 18.3 0.0 0.0071 16.4 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix domain ResIII PF04851.10 EFW99536.1 - 0.0029 17.4 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2192 PF09958.4 EFW99536.1 - 0.24 10.5 0.0 0.43 9.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) Pkinase PF00069.20 EFW99537.1 - 5.9e-46 156.7 0.0 1.2e-45 155.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99537.1 - 2.2e-17 62.9 0.0 7.6e-17 61.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 EFW99537.1 - 0.13 11.6 0.0 0.13 11.6 0.0 2.4 2 1 1 3 3 3 0 RIO1 family PsaA_PsaB PF00223.14 EFW99537.1 - 0.36 8.8 0.0 0.53 8.3 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein MRG PF05712.8 EFW99538.1 - 3.5e-33 114.1 0.0 6.6e-33 113.2 0.0 1.4 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 EFW99538.1 - 4.7e-05 23.0 1.7 0.00012 21.7 1.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain BAF1_ABF1 PF04684.8 EFW99538.1 - 0.031 13.1 0.5 0.042 12.7 0.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Chromo PF00385.19 EFW99538.1 - 0.094 12.4 0.8 0.23 11.1 0.5 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DUF3439 PF11921.3 EFW99541.1 - 6.9 6.4 15.7 18 5.1 10.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.7 EFW99541.1 - 9.4 3.8 6.7 13 3.3 4.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DNA_pol_A PF00476.15 EFW99542.1 - 9.4e-99 330.6 0.0 1.3e-98 330.1 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family A WD40 PF00400.27 EFW99543.1 - 9.2e-17 60.2 4.4 6.5e-07 28.9 0.0 6.9 7 0 0 7 7 7 2 WD domain, G-beta repeat PCI PF01399.22 EFW99543.1 - 2e-10 40.8 0.0 5.5e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 PCI domain Serglycin PF04360.7 EFW99543.1 - 0.00032 20.4 0.4 0.00032 20.4 0.3 2.8 2 0 0 2 2 2 1 Serglycin RPN7 PF10602.4 EFW99543.1 - 0.003 16.9 0.1 0.0074 15.6 0.0 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN7 DUF3731 PF12531.3 EFW99543.1 - 0.058 12.9 1.6 4 6.8 0.1 2.3 2 0 0 2 2 2 0 DNA-K related protein Mlf1IP PF10248.4 EFW99543.1 - 0.13 11.8 0.0 0.33 10.5 0.0 1.6 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein DUF3414 PF11894.3 EFW99544.1 - 0 1269.9 3.8 0 1269.6 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) Ribosomal_S28e PF01200.13 EFW99545.1 - 1.6e-29 101.4 0.9 2.3e-29 100.9 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S28e ThiS PF02597.15 EFW99545.1 - 5.4e-07 29.9 0.0 1.3e-06 28.7 0.0 1.7 1 1 0 1 1 1 1 ThiS family IBR PF01485.16 EFW99546.1 - 2.6e-08 33.5 21.0 7.8e-06 25.6 3.0 3.5 4 0 0 4 4 4 2 IBR domain Cullin PF00888.17 EFW99547.1 - 8.6e-114 381.2 0.0 2.9e-113 379.4 0.0 1.8 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 EFW99547.1 - 2.1e-26 91.5 1.1 6.1e-26 90.0 0.8 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF2688 PF10892.3 EFW99547.1 - 0.029 14.0 0.1 9.3 6.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) IF4E PF01652.13 EFW99548.1 - 1.8e-59 199.9 0.1 2.2e-59 199.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DnaJ PF00226.26 EFW99549.1 - 2.1e-26 91.4 2.6 3.6e-26 90.6 1.8 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EFW99549.1 - 1.1e-20 73.2 0.0 2e-17 62.8 0.0 2.7 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EFW99549.1 - 1.9e-14 53.4 17.7 5.2e-14 52.0 12.3 1.8 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 EFW99549.1 - 0.058 13.0 9.5 0.11 12.1 1.6 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family zinc-ribbons_6 PF07191.7 EFW99549.1 - 0.18 11.5 5.8 5.1 6.9 1.0 2.5 2 0 0 2 2 2 0 zinc-ribbons DUF2614 PF11023.3 EFW99549.1 - 0.29 10.9 5.3 5.8 6.7 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2614) zf-RING_3 PF14369.1 EFW99549.1 - 0.63 10.0 3.5 21 5.1 0.1 2.9 3 0 0 3 3 3 0 zinc-finger Atg14 PF10186.4 EFW99550.1 - 0.13 11.1 0.2 0.23 10.3 0.1 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1765 PF08578.5 EFW99551.1 - 6.4e-46 155.5 0.3 1.3e-45 154.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) PGAP1 PF07819.8 EFW99551.1 - 1.6e-08 34.4 0.0 4.3e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 EFW99551.1 - 6.6e-05 22.2 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) WD40 PF00400.27 EFW99551.1 - 0.017 14.9 2.1 1.5 8.7 0.0 4.3 3 0 0 3 3 3 0 WD domain, G-beta repeat DKCLD PF08068.7 EFW99551.1 - 0.021 14.7 0.1 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 DKCLD (NUC011) domain Ank PF00023.25 EFW99552.1 - 1.1e-16 59.6 0.2 6.5e-07 28.8 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 EFW99552.1 - 7.6e-16 58.2 2.0 3.8e-09 36.7 1.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFW99552.1 - 6e-11 42.5 0.3 1.1e-05 25.8 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99552.1 - 4.5e-10 38.7 0.2 0.031 14.5 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 EFW99552.1 - 6.2e-08 32.6 0.5 0.0033 17.6 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Shikimate_DH PF01488.15 EFW99552.1 - 0.0036 17.3 0.1 0.0073 16.4 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase vWA-TerF-like PF10138.4 EFW99552.1 - 0.015 15.1 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus Pga1 PF10333.4 EFW99553.1 - 0.02 14.5 0.4 0.044 13.4 0.0 1.7 2 0 0 2 2 2 0 GPI-Mannosyltransferase II co-activator fn3 PF00041.16 EFW99553.1 - 0.075 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III domain L51_S25_CI-B8 PF05047.11 EFW99554.1 - 1.4e-14 53.5 0.1 2.2e-14 52.9 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain SPT2 PF08243.6 EFW99555.1 - 1e-08 35.4 23.1 3.7e-08 33.6 16.1 1.8 1 1 0 1 1 1 1 SPT2 chromatin protein Nop14 PF04147.7 EFW99555.1 - 1.1 7.0 12.1 1.6 6.5 8.4 1.2 1 0 0 1 1 1 0 Nop14-like family SNARE_assoc PF09335.6 EFW99556.1 - 8.6e-15 55.0 5.2 8.6e-15 55.0 3.6 2.2 1 1 1 2 2 2 1 SNARE associated Golgi protein DUF883 PF05957.8 EFW99556.1 - 0.064 13.6 0.3 0.064 13.6 0.2 2.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) BAH PF01426.13 EFW99557.1 - 5.9e-05 22.8 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 BAH domain PHD PF00628.24 EFW99557.1 - 0.0044 16.6 2.9 0.013 15.1 2.0 1.8 1 0 0 1 1 1 1 PHD-finger zf-RING-like PF08746.6 EFW99557.1 - 0.0064 16.4 0.3 0.017 15.1 0.2 1.6 1 0 0 1 1 1 1 RING-like domain FANCL_C PF11793.3 EFW99557.1 - 0.93 9.4 6.1 0.23 11.4 0.9 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING_2 PF13639.1 EFW99557.1 - 1.3 8.8 4.1 3 7.7 0.5 2.4 2 0 0 2 2 2 0 Ring finger domain F_actin_cap_B PF01115.12 EFW99558.1 - 2.7e-102 341.1 0.0 4.8e-102 340.2 0.0 1.4 1 0 0 1 1 1 1 F-actin capping protein, beta subunit SNF2_N PF00176.18 EFW99558.1 - 3.7e-57 193.4 0.0 5.8e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFW99558.1 - 2.2e-12 46.6 0.1 1.1e-11 44.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ABC2_membrane PF01061.19 EFW99559.1 - 9e-76 253.6 51.4 2.1e-39 134.9 13.5 3.9 3 1 1 4 4 4 3 ABC-2 type transporter ABC_tran PF00005.22 EFW99559.1 - 1.7e-37 128.7 0.0 2e-18 66.9 0.0 2.3 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 EFW99559.1 - 1.9e-29 101.3 0.0 4.2e-27 93.8 0.0 2.6 2 0 0 2 2 2 1 CDR ABC transporter ABC2_membrane_3 PF12698.2 EFW99559.1 - 5.4e-09 35.5 32.8 8.3e-06 25.0 10.4 2.5 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_25 PF13481.1 EFW99559.1 - 3.6e-07 29.7 0.1 0.002 17.5 0.1 2.7 3 0 0 3 3 3 2 AAA domain ABC_trans_N PF14510.1 EFW99559.1 - 1.3e-06 28.3 0.1 3.2e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_16 PF13191.1 EFW99559.1 - 5.8e-05 23.1 0.5 0.011 15.6 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFW99559.1 - 8.6e-05 22.6 0.0 0.026 14.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFW99559.1 - 0.00042 19.5 0.0 0.0046 16.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_28 PF13521.1 EFW99559.1 - 0.0018 18.2 0.5 0.34 10.8 0.2 2.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 EFW99559.1 - 0.0023 17.4 0.7 0.31 10.4 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 EFW99559.1 - 0.0024 17.3 0.5 0.079 12.5 0.1 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.1 EFW99559.1 - 0.0035 17.2 0.0 1.2 9.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.1 EFW99559.1 - 0.012 15.9 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 EFW99559.1 - 0.015 15.0 0.3 4.3 7.1 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain Arch_ATPase PF01637.13 EFW99559.1 - 0.02 14.5 0.0 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase AAA_17 PF13207.1 EFW99559.1 - 0.023 15.5 0.0 1.3 9.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EFW99559.1 - 0.037 13.5 0.2 1.5 8.3 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation UPF0079 PF02367.12 EFW99559.1 - 0.14 11.8 0.5 3.6 7.2 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Miro PF08477.8 EFW99559.1 - 0.15 12.6 0.0 4.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein Zeta_toxin PF06414.7 EFW99559.1 - 0.17 10.9 0.2 8.8 5.3 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_21 PF13304.1 EFW99559.1 - 0.18 11.7 0.0 2 8.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain NACHT PF05729.7 EFW99559.1 - 0.19 11.3 0.6 3.7 7.1 0.2 2.3 2 0 0 2 2 2 0 NACHT domain MFS_1 PF07690.11 EFW99560.1 - 1.4e-33 116.0 18.8 1.4e-33 116.0 13.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Coatomer_WDAD PF04053.9 EFW99561.1 - 6.2e-168 559.1 0.0 9.2e-168 558.6 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 EFW99561.1 - 6.9e-44 146.2 8.0 9.5e-10 37.9 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 EFW99561.1 - 0.00021 19.5 2.4 0.23 9.5 1.4 3.5 1 1 1 2 2 2 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 EFW99561.1 - 0.026 14.3 0.0 4.7 7.0 0.0 3.1 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Cys_Met_Meta_PP PF01053.15 EFW99562.1 - 5.5e-117 390.3 0.3 1.8e-98 329.3 0.0 2.0 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EFW99562.1 - 0.00042 19.1 0.1 0.00065 18.5 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFW99562.1 - 0.0012 17.9 1.8 0.0029 16.7 0.9 1.8 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 EFW99562.1 - 0.066 12.1 0.1 0.18 10.7 0.0 1.5 1 1 1 2 2 2 0 Aminotransferase class I and II GDPD PF03009.12 EFW99563.1 - 7.8e-67 225.4 0.0 2.5e-66 223.8 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_4 PF13637.1 EFW99563.1 - 1.4e-33 114.6 3.3 1.5e-11 44.4 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFW99563.1 - 2.6e-33 114.2 0.1 1.8e-11 44.1 0.0 4.6 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) SPX PF03105.14 EFW99563.1 - 1.3e-29 103.8 2.8 2.8e-16 60.1 0.7 3.3 1 1 1 2 2 2 2 SPX domain Ank PF00023.25 EFW99563.1 - 4.6e-26 89.2 5.4 2.1e-06 27.2 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 EFW99563.1 - 1.3e-23 82.4 2.3 5.6e-06 26.4 0.0 6.8 4 1 3 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99563.1 - 3.7e-16 57.6 4.0 0.00056 19.8 0.0 7.0 6 0 0 6 6 6 4 Ankyrin repeat TraD PF06412.6 EFW99563.1 - 0.059 12.9 0.0 0.21 11.2 0.0 1.9 1 0 0 1 1 1 0 Conjugal transfer protein TraD RmlD_sub_bind PF04321.12 EFW99565.1 - 2.4e-57 194.0 0.0 3.6e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 EFW99565.1 - 2.4e-25 89.3 0.0 3.2e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFW99565.1 - 6.2e-10 38.2 0.1 3e-09 35.9 0.1 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFW99565.1 - 7e-10 38.2 0.1 6e-08 31.9 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 EFW99565.1 - 1.1e-09 37.6 0.5 1.7e-07 30.4 0.4 2.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EFW99565.1 - 4.5e-07 30.0 0.1 7.1e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding Semialdhyde_dh PF01118.19 EFW99565.1 - 0.0042 17.3 0.0 0.046 14.0 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EFW99565.1 - 0.0046 16.8 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.8 EFW99565.1 - 0.016 14.4 1.8 0.38 9.9 0.3 2.9 2 1 0 2 2 2 0 NmrA-like family adh_short PF00106.20 EFW99565.1 - 0.027 14.3 0.2 0.34 10.8 0.1 2.4 1 1 0 1 1 1 0 short chain dehydrogenase Ldh_1_N PF00056.18 EFW99565.1 - 0.15 11.8 1.1 3.8 7.3 0.1 2.6 2 2 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DRIM PF07539.7 EFW99566.1 - 1.7e-32 111.7 0.0 2.1e-31 108.2 0.0 3.0 4 0 0 4 4 4 1 Down-regulated in metastasis RNA_polI_A34 PF08208.6 EFW99566.1 - 0.0017 18.0 0.4 0.0017 18.0 0.3 1.9 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 CLASP_N PF12348.3 EFW99566.1 - 0.059 12.7 0.1 19 4.4 0.0 3.8 3 0 0 3 3 3 0 CLASP N terminal Ycf1 PF05758.7 EFW99566.1 - 0.11 10.1 0.8 0.22 9.1 0.5 1.4 1 0 0 1 1 1 0 Ycf1 HEAT_2 PF13646.1 EFW99566.1 - 0.11 12.7 32.3 0.18 12.1 0.1 8.8 8 3 0 8 8 8 0 HEAT repeats SMN PF06003.7 EFW99566.1 - 0.13 11.3 2.3 0.29 10.1 1.6 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) HEAT PF02985.17 EFW99566.1 - 0.6 10.3 0.0 0.6 10.3 0.0 9.5 10 1 1 11 11 11 0 HEAT repeat HEAT_EZ PF13513.1 EFW99566.1 - 0.66 10.5 36.8 0.77 10.3 0.7 10.4 10 0 0 10 10 10 0 HEAT-like repeat Nop14 PF04147.7 EFW99566.1 - 1.3 6.8 24.8 0.36 8.7 6.9 2.5 2 0 0 2 2 2 0 Nop14-like family RAP1 PF07218.6 EFW99566.1 - 3.7 5.5 0.4 6.1 4.8 0.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) zf-C3HC4_3 PF13920.1 EFW99567.1 - 1.3e-10 40.7 7.1 1.9e-10 40.2 4.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFW99567.1 - 6.8e-09 35.4 9.0 1.1e-08 34.7 6.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFW99567.1 - 4.4e-08 33.0 8.7 6.8e-08 32.4 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFW99567.1 - 6.6e-07 28.9 8.3 1e-06 28.3 5.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFW99567.1 - 4e-06 26.3 8.1 6.3e-06 25.7 5.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFW99567.1 - 6.3e-05 22.7 2.9 0.00011 21.9 2.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 EFW99567.1 - 0.001 18.9 7.8 0.0018 18.1 5.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 EFW99567.1 - 0.0016 17.9 3.3 0.0032 16.9 2.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.2 EFW99567.1 - 0.071 13.2 2.4 0.14 12.2 1.6 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger PolC_DP2 PF03833.8 EFW99567.1 - 0.074 10.7 0.5 0.098 10.3 0.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-CHY PF05495.7 EFW99567.1 - 0.23 11.6 6.3 0.39 10.9 4.3 1.2 1 0 0 1 1 1 0 CHY zinc finger zf-RING_4 PF14570.1 EFW99567.1 - 0.29 10.7 5.8 0.48 10.0 4.0 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 EFW99567.1 - 0.46 10.2 9.1 0.06 13.0 1.4 2.2 2 0 0 2 2 2 0 RING-type zinc-finger ATP-grasp_2 PF08442.5 EFW99569.1 - 3.3e-08 33.1 0.0 5.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Pro_isomerase PF00160.16 EFW99570.1 - 3.4e-40 137.7 0.0 7e-40 136.7 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4604 PF15377.1 EFW99570.1 - 0.021 15.0 1.6 0.021 15.0 1.1 4.2 2 2 2 4 4 4 0 Domain of unknown function (DUF4604) Glyco_hydro_72 PF03198.9 EFW99571.1 - 2.9e-115 384.5 0.0 3.5e-115 384.3 0.0 1.0 1 0 0 1 1 1 1 Glucanosyltransferase MFS_1 PF07690.11 EFW99572.1 - 3.4e-30 104.9 37.4 4.8e-30 104.4 25.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily VPS28 PF03997.7 EFW99573.1 - 2.8e-51 173.8 0.0 3.8e-51 173.3 0.0 1.2 1 0 0 1 1 1 1 VPS28 protein PX PF00787.19 EFW99575.1 - 9.7e-18 64.0 0.0 1.5e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 PX domain Pro_isomerase PF00160.16 EFW99576.1 - 1.4e-39 135.7 0.0 1.6e-39 135.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ago_hook PF10427.4 EFW99576.1 - 0.14 12.1 0.6 0.19 11.7 0.4 1.1 1 0 0 1 1 1 0 Argonaute hook CTDII PF01556.13 EFW99577.1 - 2.2e-15 56.3 0.0 1.5e-14 53.6 0.0 2.0 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EFW99577.1 - 4.8e-05 23.3 5.3 9.3e-05 22.3 3.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Ferritin_2 PF13668.1 EFW99578.1 - 1.1e-37 129.0 0.0 2e-37 128.2 0.0 1.5 1 0 0 1 1 1 1 Ferritin-like domain DUF455 PF04305.9 EFW99578.1 - 0.066 12.4 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF455) DUF3425 PF11905.3 EFW99580.1 - 7.4e-16 58.2 1.3 4.4e-15 55.7 0.9 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) PAP1 PF08601.5 EFW99580.1 - 6.6 6.3 8.0 3.9 7.0 3.4 1.9 2 0 0 2 2 2 0 Transcription factor PAP1 Glyco_transf_22 PF03901.12 EFW99581.1 - 8.9e-38 130.3 7.2 1.5e-37 129.6 5.0 1.4 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Eno-Rase_NADH_b PF12242.3 EFW99581.1 - 0.045 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RRM_1 PF00076.17 EFW99582.1 - 7.4e-23 79.9 0.0 1.1e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99582.1 - 1.1e-15 57.3 0.0 1.7e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99582.1 - 1.3e-10 40.9 0.0 1.9e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PH_10 PF15411.1 EFW99583.1 - 1.9e-26 92.4 0.4 3.8e-26 91.5 0.1 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain VWA_3 PF13768.1 EFW99583.1 - 5.2e-10 39.2 0.0 3.1e-09 36.7 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain zf-RING_2 PF13639.1 EFW99583.1 - 2.9e-08 33.4 5.6 5.6e-08 32.4 3.9 1.5 1 0 0 1 1 1 1 Ring finger domain VWA PF00092.23 EFW99583.1 - 1.5e-06 28.0 0.0 2.9e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-C3HC4_3 PF13920.1 EFW99583.1 - 0.00025 20.6 2.3 0.00045 19.8 1.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFW99583.1 - 0.00031 20.4 5.2 0.00052 19.6 3.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFW99583.1 - 0.002 18.1 4.7 0.0038 17.2 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFW99583.1 - 0.0033 17.5 1.9 0.0071 16.4 1.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EFW99583.1 - 0.014 15.0 4.7 0.026 14.1 3.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.24 EFW99583.1 - 0.051 13.7 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 PH domain zf-C4_Topoisom PF01396.14 EFW99583.1 - 0.092 12.2 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Topoisomerase DNA binding C4 zinc finger DUF1147 PF06615.6 EFW99583.1 - 0.11 12.2 0.4 0.36 10.7 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) zf-RING-like PF08746.6 EFW99583.1 - 0.75 9.8 4.1 1.5 8.9 2.8 1.5 1 0 0 1 1 1 0 RING-like domain MRP-L46 PF11788.3 EFW99584.1 - 1e-21 77.6 0.0 2.6e-21 76.3 0.0 1.7 1 1 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.23 EFW99584.1 - 0.0002 20.9 0.0 0.00036 20.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain CwfJ_C_1 PF04677.10 EFW99585.1 - 1.6e-25 89.1 0.0 3.8e-24 84.6 0.0 2.3 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 EFW99585.1 - 3.7e-21 75.4 0.1 6.5e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 THF_DHG_CYH PF00763.18 EFW99587.1 - 1.7e-19 69.9 0.1 2.5e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 EFW99587.1 - 4.5e-13 48.5 0.1 1.7e-08 33.7 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain U1snRNP70_N PF12220.3 EFW99588.1 - 1.2e-29 102.4 1.3 2.2e-29 101.6 0.6 1.6 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 EFW99588.1 - 4.3e-16 58.2 0.1 1.7e-15 56.3 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99588.1 - 9.7e-13 47.8 0.0 1.7e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99588.1 - 3.3e-10 39.6 0.0 7.1e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) dCMP_cyt_deam_1 PF00383.17 EFW99589.1 - 1.1e-16 60.2 0.0 1.9e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 EFW99589.1 - 0.018 14.8 1.1 0.26 11.1 0.3 2.2 1 1 1 2 2 2 0 Bd3614-like deaminase Fcf1 PF04900.7 EFW99590.1 - 2.1e-27 95.1 0.1 2.1e-27 95.1 0.0 2.4 4 0 0 4 4 4 1 Fcf1 PP2C_2 PF13672.1 EFW99590.1 - 8.7e-06 25.2 0.1 1.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 EFW99590.1 - 0.0027 17.4 0.0 0.0053 16.4 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) YL1 PF05764.8 EFW99590.1 - 0.0052 16.4 11.6 0.0052 16.4 8.0 1.6 2 0 0 2 2 2 1 YL1 nuclear protein Nucleoplasmin PF03066.10 EFW99590.1 - 0.049 13.1 2.0 0.096 12.2 1.4 1.4 1 0 0 1 1 1 0 Nucleoplasmin CDC45 PF02724.9 EFW99590.1 - 1.1 7.2 9.1 2 6.3 6.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.6 EFW99590.1 - 5 5.6 12.9 0.21 10.2 3.5 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_L21p PF00829.16 EFW99591.1 - 0.0035 17.4 0.1 0.71 10.0 0.0 2.2 2 0 0 2 2 2 2 Ribosomal prokaryotic L21 protein Mannosyl_trans3 PF11051.3 EFW99593.1 - 1.1e-70 238.0 0.0 1.1e-69 234.7 0.0 2.3 2 1 0 2 2 2 1 Mannosyltransferase putative Glyco_transf_8 PF01501.15 EFW99593.1 - 0.039 13.2 0.0 0.086 12.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 8 Citrate_synt PF00285.16 EFW99594.1 - 4.8e-19 68.3 0.0 3.3e-16 58.9 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase CoA_binding PF02629.14 EFW99594.1 - 2.4e-18 66.4 0.0 1e-17 64.3 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 EFW99594.1 - 2.8e-14 52.9 0.1 4.6e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 EFW99594.1 - 0.00014 21.4 0.1 0.00067 19.2 0.0 2.1 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EFW99594.1 - 0.074 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain RTC4 PF14474.1 EFW99595.1 - 7.4e-30 103.4 0.0 1.2e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 RTC4-like domain ChaC PF04752.7 EFW99596.1 - 1.8e-43 148.5 0.1 6.9e-43 146.6 0.0 1.8 1 1 0 1 1 1 1 ChaC-like protein tRNA-synt_1g PF09334.6 EFW99597.1 - 3.1e-64 217.0 1.3 5.9e-35 120.6 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Acetyltransf_1 PF00583.19 EFW99597.1 - 9.2e-14 51.2 0.1 2.2e-13 50.0 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFW99597.1 - 3.7e-05 23.3 0.9 0.00012 21.7 0.1 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.1 EFW99597.1 - 0.0026 17.8 0.2 0.012 15.7 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFW99597.1 - 0.0058 16.4 1.7 0.085 12.7 0.1 3.4 5 0 0 5 5 5 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFW99597.1 - 0.024 14.7 0.0 0.057 13.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.1 EFW99597.1 - 0.05 13.3 0.1 0.36 10.6 0.0 2.2 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase DUF2406 PF10295.4 EFW99598.1 - 4.2e-19 68.8 0.2 4.2e-19 68.8 0.1 2.8 2 1 0 2 2 2 1 Uncharacterised protein (DUF2406) Ndc1_Nup PF09531.5 EFW99598.1 - 1.9 6.7 5.9 2.5 6.4 4.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PX PF00787.19 EFW99599.1 - 3.7e-20 71.8 0.6 1e-19 70.3 0.0 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 EFW99599.1 - 2e-10 40.3 6.3 1.2e-05 24.6 0.2 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.13 EFW99599.1 - 2.1e-05 24.1 7.7 0.00033 20.2 0.6 2.1 2 0 0 2 2 2 2 BAR domain Reo_sigmaC PF04582.7 EFW99599.1 - 0.0057 15.8 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein TerB PF05099.8 EFW99599.1 - 0.04 13.6 8.0 2 8.1 1.3 3.2 3 0 0 3 3 3 0 Tellurite resistance protein TerB IncA PF04156.9 EFW99599.1 - 0.43 10.1 6.2 0.97 8.9 0.1 2.4 2 0 0 2 2 2 0 IncA protein DUF4404 PF14357.1 EFW99599.1 - 4.2 7.8 5.8 44 4.5 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) RNA_pol_Rbc25 PF08292.7 EFW99601.1 - 8.1e-28 97.0 0.1 1.3e-27 96.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 EFW99601.1 - 1.9e-13 50.2 0.1 3.8e-13 49.3 0.0 1.5 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 BTB PF00651.26 EFW99602.1 - 5.4e-05 23.1 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain EF-hand_7 PF13499.1 EFW99603.1 - 7.6e-19 67.6 10.5 2.5e-09 37.1 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 EFW99603.1 - 2.1e-18 64.4 12.5 1.7e-05 24.2 0.0 5.3 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.27 EFW99603.1 - 2.8e-17 60.6 19.9 7.2e-07 28.0 0.0 5.8 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 EFW99603.1 - 7.9e-12 44.6 17.2 5.7e-05 22.6 0.0 4.2 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 EFW99603.1 - 5.8e-10 38.0 13.6 9.7e-06 24.6 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_2 PF09068.6 EFW99603.1 - 0.01 15.9 0.1 6.5 6.8 0.0 3.3 3 1 0 3 3 3 0 EF hand Scm3 PF10384.4 EFW99603.1 - 0.18 11.3 0.3 19 4.7 0.0 2.4 2 0 0 2 2 2 0 Centromere protein Scm3 SET PF00856.23 EFW99604.1 - 1.6e-10 41.5 0.6 7.2e-08 32.8 0.0 2.4 2 1 0 2 2 2 2 SET domain zf-MYND PF01753.13 EFW99604.1 - 4.3e-09 36.0 13.0 4.3e-09 36.0 9.0 2.1 2 0 0 2 2 2 1 MYND finger Clathrin PF00637.15 EFW99605.1 - 3.7e-201 658.8 33.2 1.4e-33 115.5 1.0 7.7 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.15 EFW99605.1 - 1.1e-29 100.6 0.5 0.00012 22.0 0.0 7.6 7 0 0 7 7 7 7 Clathrin propeller repeat Clathrin_H_link PF13838.1 EFW99605.1 - 4.4e-27 93.7 0.1 1.8e-26 91.7 0.1 2.2 1 0 0 1 1 1 1 Clathrin-H-link Clathrin-link PF09268.5 EFW99605.1 - 0.00012 20.9 2.5 0.00057 18.8 0.3 2.8 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Ank_3 PF13606.1 EFW99605.1 - 0.052 13.7 0.1 24 5.5 0.0 4.5 5 0 0 5 5 5 0 Ankyrin repeat TPR_7 PF13176.1 EFW99605.1 - 0.1 12.4 8.3 5.5 7.0 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat PPR PF01535.15 EFW99605.1 - 0.58 10.2 3.3 9.5 6.4 0.0 4.7 6 0 0 6 6 6 0 PPR repeat TPR_14 PF13428.1 EFW99605.1 - 0.73 10.6 16.4 16 6.4 0.2 8.0 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFW99605.1 - 5.9 7.0 9.8 12 6.1 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Hormone_4 PF00220.12 EFW99606.1 - 0.63 9.8 3.2 31 4.5 0.2 3.0 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Band_7 PF01145.20 EFW99607.1 - 3.6e-23 82.3 1.7 6.3e-23 81.5 1.2 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 EFW99607.1 - 0.026 14.0 0.1 0.036 13.5 0.1 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus CENP-Q PF13094.1 EFW99608.1 - 3.9e-33 114.7 1.0 5.1e-33 114.3 0.7 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Vps5 PF09325.5 EFW99608.1 - 0.0071 15.6 0.9 0.0071 15.6 0.7 1.6 2 0 0 2 2 2 1 Vps5 C terminal like DUF2353 PF09789.4 EFW99608.1 - 0.051 12.8 2.4 0.068 12.4 1.5 1.3 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Tropomyosin_1 PF12718.2 EFW99608.1 - 0.12 12.2 4.4 0.084 12.7 1.9 1.7 2 0 0 2 2 2 0 Tropomyosin like NPV_P10 PF05531.7 EFW99608.1 - 0.89 9.8 3.5 5.1 7.4 0.2 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ADIP PF11559.3 EFW99608.1 - 1.1 9.1 7.5 0.76 9.6 2.6 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding OmpH PF03938.9 EFW99608.1 - 3.7 7.4 5.9 6.5 6.6 4.0 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CBS PF00571.23 EFW99609.1 - 3.7e-05 23.4 0.0 0.32 10.8 0.0 2.3 2 0 0 2 2 2 2 CBS domain MDMPI_C PF07398.6 EFW99609.1 - 0.062 13.8 1.6 0.062 13.8 1.1 2.6 2 1 1 3 3 3 0 MDMPI C-terminal domain DUF348 PF03990.9 EFW99609.1 - 0.27 10.8 1.8 0.28 10.7 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF348) Sugar_tr PF00083.19 EFW99610.1 - 2.4e-91 306.6 26.9 2.9e-91 306.3 18.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFW99610.1 - 3e-20 72.2 52.7 2e-19 69.5 18.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily CAF1 PF04857.15 EFW99611.1 - 1.1e-27 96.9 0.0 3.9e-21 75.5 0.0 2.1 1 1 1 2 2 2 2 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.15 EFW99611.1 - 0.0016 17.9 0.2 0.63 9.5 0.0 2.3 2 0 0 2 2 2 2 3'-5' exonuclease Zn_clus PF00172.13 EFW99612.1 - 1.9e-08 34.0 5.0 3.7e-08 33.1 3.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFW99612.1 - 1.9e-07 30.2 0.1 5.3e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain ATP-synt_ab PF00006.20 EFW99613.1 - 7.2e-42 143.3 0.0 1e-41 142.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EFW99613.1 - 4e-28 98.1 0.3 2.5e-27 95.5 0.2 2.1 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain Abhydrolase_6 PF12697.2 EFW99614.1 - 1.8e-14 54.1 0.4 1.8e-13 50.9 0.3 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFW99614.1 - 1.6e-11 44.2 0.0 4.7e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFW99614.1 - 6.7e-08 32.3 0.0 2.4e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFW99614.1 - 0.00038 19.7 0.0 0.0013 18.0 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.15 EFW99614.1 - 0.00055 19.4 0.0 0.00085 18.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S15 PF02129.13 EFW99614.1 - 0.012 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Globin PF00042.17 EFW99615.1 - 4.9e-08 33.2 0.0 8.1e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Globin Protoglobin PF11563.3 EFW99615.1 - 0.00012 21.7 0.1 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Protoglobin FAD_binding_6 PF00970.19 EFW99615.1 - 0.0068 16.5 0.0 0.029 14.5 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain DUF106 PF01956.11 EFW99616.1 - 1.2e-39 135.4 4.3 2.8e-38 131.0 2.9 2.1 1 1 0 1 1 1 1 Integral membrane protein DUF106 Pyr_redox PF00070.22 EFW99617.1 - 4.1e-15 55.9 0.4 4.3e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFW99617.1 - 6.9e-09 35.8 3.3 0.0062 16.4 0.1 4.6 2 2 2 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFW99617.1 - 4.3e-08 32.4 1.7 0.06 12.2 0.1 3.2 3 0 0 3 3 3 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFW99617.1 - 3.5e-07 30.4 0.3 0.0042 17.1 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFW99617.1 - 0.00021 20.3 0.0 0.00038 19.5 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 EFW99617.1 - 0.0038 15.9 2.7 0.58 8.7 0.0 2.9 2 1 1 3 3 3 2 Tryptophan halogenase NAD_binding_7 PF13241.1 EFW99617.1 - 0.0079 16.4 0.2 0.47 10.7 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.7 EFW99617.1 - 0.017 14.0 1.8 0.071 12.0 0.0 2.3 2 1 1 3 3 3 0 Lycopene cyclase protein TrkA_N PF02254.13 EFW99617.1 - 0.078 12.9 0.9 0.51 10.3 0.0 2.4 3 0 0 3 3 3 0 TrkA-N domain FAD_binding_2 PF00890.19 EFW99617.1 - 0.084 11.6 0.1 2.2 7.0 0.0 2.7 3 0 0 3 3 3 0 FAD binding domain FAD_binding_3 PF01494.14 EFW99617.1 - 0.41 9.6 2.7 18 4.2 0.4 2.8 2 1 1 3 3 3 0 FAD binding domain Glyco_hydro_28 PF00295.12 EFW99620.1 - 1.4e-82 277.3 9.8 1.8e-82 276.9 6.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 EFW99620.1 - 9e-05 22.2 25.5 0.00058 19.6 12.9 3.0 3 1 0 3 3 3 2 Right handed beta helix region PAN_4 PF14295.1 EFW99620.1 - 0.094 12.4 0.1 0.29 10.8 0.0 1.8 1 0 0 1 1 1 0 PAN domain SPC25 PF06703.6 EFW99621.1 - 4.4e-44 149.9 0.1 6.5e-44 149.3 0.0 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4117 PF13491.1 EFW99621.1 - 0.025 14.0 0.5 0.045 13.2 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4117) DUF4540 PF15073.1 EFW99621.1 - 0.07 13.6 0.1 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4540) Amidase PF01425.16 EFW99622.1 - 9.5e-101 337.7 0.0 1.2e-100 337.4 0.0 1.1 1 0 0 1 1 1 1 Amidase zf-MYND PF01753.13 EFW99622.1 - 0.048 13.5 3.6 0.1 12.4 2.5 1.5 1 0 0 1 1 1 0 MYND finger Herpes_pp38 PF04846.8 EFW99622.1 - 0.1 11.9 0.0 0.29 10.4 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein DUF410 PF04190.8 EFW99623.1 - 1.2e-50 172.4 0.0 1.5e-50 172.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) MutS_V PF00488.16 EFW99624.1 - 2.7e-76 256.0 0.0 4.5e-76 255.3 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFW99624.1 - 2.9e-39 134.9 2.0 1.3e-38 132.8 1.4 2.0 1 1 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EFW99624.1 - 2.4e-18 66.2 0.0 1.4e-17 63.7 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.12 EFW99624.1 - 5.3e-08 33.0 0.0 1.5e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.1 EFW99624.1 - 0.021 14.3 0.1 0.052 13.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EFW99624.1 - 0.45 10.8 0.0 0.86 9.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sporozoite_P67 PF05642.6 EFW99624.1 - 1.9 6.2 5.0 0.21 9.4 0.1 1.8 2 0 0 2 2 2 0 Sporozoite P67 surface antigen OB_NTP_bind PF07717.11 EFW99625.1 - 1.5e-26 92.4 0.0 2.8e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFW99625.1 - 9.6e-24 83.3 0.1 3e-23 81.7 0.0 1.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFW99625.1 - 2.6e-08 33.5 0.0 7.2e-07 28.9 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Meth_synt_2 PF01717.13 EFW99626.1 - 4.7e-145 482.6 0.0 2.1e-137 457.4 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 EFW99626.1 - 1.6e-118 395.4 0.0 2e-107 359.0 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain Peptidase_M1 PF01433.15 EFW99627.1 - 8.1e-07 28.4 0.0 0.58 9.1 0.0 3.3 3 0 0 3 3 3 3 Peptidase family M1 Glutaredoxin PF00462.19 EFW99628.1 - 4.5e-14 52.1 0.0 1.6e-13 50.4 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin LytR_C PF13399.1 EFW99628.1 - 0.038 14.3 0.5 0.069 13.5 0.3 1.4 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator DUF3375 PF11855.3 EFW99628.1 - 0.069 11.8 0.5 0.1 11.3 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) WD40 PF00400.27 EFW99629.1 - 2.2e-07 30.5 1.1 7.5e-05 22.4 0.0 3.6 3 0 0 3 3 3 1 WD domain, G-beta repeat CPSF_A PF03178.10 EFW99629.1 - 0.055 12.5 0.0 0.087 11.8 0.0 1.3 1 0 0 1 1 1 0 CPSF A subunit region PQQ_3 PF13570.1 EFW99629.1 - 0.077 13.3 1.2 6.3 7.2 0.0 3.7 3 0 0 3 3 3 0 PQQ-like domain DAGK_cat PF00781.19 EFW99629.1 - 0.11 11.8 1.4 9.6 5.6 0.0 3.2 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain HMG_box PF00505.14 EFW99630.1 - 4.2e-06 26.9 0.5 0.0078 16.4 0.3 2.8 2 0 0 2 2 2 2 HMG (high mobility group) box DUF4540 PF15073.1 EFW99630.1 - 0.016 15.7 0.3 0.032 14.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4540) DUF3504 PF12012.3 EFW99630.1 - 0.5 10.1 0.0 0.5 10.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) TFIIF_alpha PF05793.7 EFW99630.1 - 1.2 7.4 35.0 1.6 6.9 24.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Atg14 PF10186.4 EFW99630.1 - 3.5 6.4 9.5 0.57 9.0 0.6 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 AMP-binding PF00501.23 EFW99631.1 - 4.7e-69 232.7 0.0 6.2e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFW99631.1 - 6.2e-12 46.2 0.1 1.3e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M28 PF04389.12 EFW99632.1 - 0.0064 16.2 0.0 0.028 14.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M28 RRM_1 PF00076.17 EFW99633.1 - 5.9e-37 125.1 0.0 1.9e-17 62.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99633.1 - 1.4e-23 82.6 0.0 1.3e-12 47.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99633.1 - 2.2e-12 46.6 0.0 1.4e-05 24.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EFW99633.1 - 0.017 14.8 0.2 0.18 11.5 0.0 2.6 3 0 0 3 3 3 0 Limkain b1 ATG22 PF11700.3 EFW99634.1 - 1.3e-189 630.7 19.7 1.5e-189 630.4 13.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 EFW99634.1 - 0.00068 18.4 50.8 0.0065 15.2 5.0 3.4 2 1 1 3 3 3 3 Major Facilitator Superfamily Cpn60_TCP1 PF00118.19 EFW99635.1 - 4e-136 454.4 3.6 4.6e-136 454.2 2.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glyco_hydro_76 PF03663.9 EFW99636.1 - 8.9e-23 81.2 4.8 9.2e-16 58.1 0.1 3.3 3 0 0 3 3 3 3 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 EFW99636.1 - 0.011 14.7 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 WD40 PF00400.27 EFW99637.1 - 1.2e-06 28.1 2.1 0.0019 18.0 0.1 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Ribosomal_S11 PF00411.14 EFW99638.1 - 8.8e-09 35.5 0.0 2.3e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S11 Flp_N PF03930.9 EFW99638.1 - 0.07 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus ALF PF03752.8 EFW99638.1 - 0.083 12.7 0.2 0.083 12.7 0.1 2.7 3 0 0 3 3 3 0 Short repeats of unknown function Glyco_hydro_38 PF01074.17 EFW99639.1 - 7.4e-89 297.6 0.5 1.5e-88 296.6 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 EFW99639.1 - 2.3e-65 221.2 0.0 3.1e-65 220.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 EFW99639.1 - 2.2e-25 88.6 0.0 4.4e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase, middle domain HA2 PF04408.18 EFW99640.1 - 5.4e-26 90.5 0.1 2.8e-25 88.2 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EFW99640.1 - 1e-23 83.3 0.0 4.4e-23 81.2 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Hep_59 PF07052.6 EFW99640.1 - 5.3e-16 58.8 0.0 5.3e-16 58.8 0.0 3.9 3 0 0 3 3 2 1 Hepatocellular carcinoma-associated antigen 59 Helicase_C PF00271.26 EFW99640.1 - 2.4e-10 40.1 0.0 5.9e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFW99640.1 - 1.8e-07 30.8 0.0 3.4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFW99640.1 - 7.4e-05 22.9 0.2 0.00036 20.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 EFW99640.1 - 0.00059 19.7 0.0 0.36 10.6 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T2SE PF00437.15 EFW99640.1 - 0.00086 18.2 0.0 0.0023 16.8 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.4 EFW99640.1 - 0.0017 17.3 0.0 0.0042 16.0 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 EFW99640.1 - 0.015 14.3 0.0 0.031 13.4 0.0 1.4 1 0 0 1 1 1 0 KaiC SRP54 PF00448.17 EFW99640.1 - 0.019 14.3 0.7 0.06 12.7 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_14 PF13173.1 EFW99640.1 - 0.026 14.4 0.1 0.16 11.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.9 EFW99640.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_23 PF13476.1 EFW99640.1 - 0.062 13.6 1.6 0.49 10.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain PPR_2 PF13041.1 EFW99641.1 - 0.04 13.8 0.0 3.5 7.6 0.0 2.5 2 0 0 2 2 2 0 PPR repeat family Proteasome PF00227.21 EFW99643.1 - 3e-26 91.8 0.1 3e-25 88.6 0.1 2.0 1 1 0 1 1 1 1 Proteasome subunit HLH PF00010.21 EFW99645.1 - 3.1e-12 46.0 2.9 6e-12 45.0 1.2 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF2205 PF10224.4 EFW99645.1 - 0.0027 17.2 3.6 0.0034 16.9 0.1 2.6 3 0 0 3 3 3 1 Predicted coiled-coil protein (DUF2205) HALZ PF02183.13 EFW99645.1 - 0.033 13.8 0.1 0.091 12.4 0.1 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF972 PF06156.8 EFW99645.1 - 0.04 14.2 0.9 0.04 14.2 0.6 2.0 2 1 0 2 2 1 0 Protein of unknown function (DUF972) DUF1875 PF08961.5 EFW99645.1 - 0.055 12.7 2.9 0.051 12.8 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1875) DUF1640 PF07798.6 EFW99645.1 - 0.058 13.4 3.4 0.092 12.7 1.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4618 PF15397.1 EFW99645.1 - 0.07 12.4 6.5 0.016 14.5 2.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) ATG16 PF08614.6 EFW99645.1 - 0.72 9.6 9.0 0.089 12.6 3.2 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DivIC PF04977.10 EFW99645.1 - 0.84 9.1 3.5 0.46 9.9 0.2 2.2 2 1 0 2 2 2 0 Septum formation initiator APG6 PF04111.7 EFW99645.1 - 0.94 8.4 4.1 1.6 7.7 2.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 EFW99645.1 - 8 6.0 8.0 0.98 8.9 2.1 1.8 2 1 0 2 2 2 0 IncA protein R-HINP1I PF11463.3 EFW99646.1 - 0.073 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease Malate_DH PF12434.3 EFW99646.1 - 1.3 8.7 7.3 0.21 11.3 0.4 2.9 3 0 0 3 3 3 0 Malate dehydrogenase enzyme Sugar_tr PF00083.19 EFW99647.1 - 3.1e-22 78.7 29.5 6.6e-13 48.0 9.1 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2686 PF10887.3 EFW99647.1 - 0.026 13.2 0.0 0.048 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2686) Alpha_L_fucos PF01120.12 EFW99648.1 - 9.8e-84 281.2 6.5 1.4e-83 280.6 4.5 1.2 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.1 EFW99648.1 - 0.12 12.3 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 DUF3824 PF12868.2 EFW99649.1 - 0.00038 21.3 11.3 0.00038 21.3 7.8 6.9 6 1 1 8 8 8 3 Domain of unknwon function (DUF3824) Gly-zipper_OmpA PF13436.1 EFW99649.1 - 0.12 12.0 0.0 0.12 12.0 0.0 4.9 4 1 1 5 5 5 0 Glycine-zipper containing OmpA-like membrane domain UCH PF00443.24 EFW99650.1 - 1.5e-48 165.2 0.0 2.8e-48 164.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFW99650.1 - 1.3e-21 77.3 0.4 2.9e-21 76.1 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF2422 PF10337.4 EFW99650.1 - 0.025 13.3 1.9 0.042 12.6 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) FHIPEP PF00771.15 EFW99650.1 - 0.24 9.7 0.8 0.35 9.1 0.6 1.1 1 0 0 1 1 1 0 FHIPEP family Peptidase_C98 PF15499.1 EFW99650.1 - 0.36 10.0 4.1 9.3 5.4 2.8 2.5 1 1 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Ycf1 PF05758.7 EFW99650.1 - 8 4.0 6.9 13 3.3 4.8 1.2 1 0 0 1 1 1 0 Ycf1 Rhodanese PF00581.15 EFW99651.1 - 2.4e-12 47.1 0.0 4.8e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain polyprenyl_synt PF00348.12 EFW99652.1 - 5.5e-67 225.3 0.0 6.6e-67 225.0 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase HSF_DNA-bind PF00447.12 EFW99653.1 - 7.6e-29 99.9 0.4 1.5e-28 98.9 0.3 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding DivIC PF04977.10 EFW99653.1 - 0.0052 16.2 3.0 1.1 8.8 0.0 2.6 2 0 0 2 2 2 2 Septum formation initiator ATG16 PF08614.6 EFW99653.1 - 0.018 14.8 0.4 0.018 14.8 0.3 3.0 4 0 0 4 4 4 0 Autophagy protein 16 (ATG16) FHIPEP PF00771.15 EFW99653.1 - 0.068 11.4 0.4 0.1 10.8 0.3 1.1 1 0 0 1 1 1 0 FHIPEP family Kinesin-relat_1 PF12711.2 EFW99653.1 - 0.15 12.5 3.2 0.19 12.1 0.4 2.3 2 0 0 2 2 2 0 Kinesin motor DnaB PF00772.16 EFW99653.1 - 0.15 11.9 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain DUF904 PF06005.7 EFW99653.1 - 3.1 8.1 9.5 3.1 8.1 0.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF904) MFS_1 PF07690.11 EFW99654.1 - 3.8e-33 114.6 27.9 3.8e-33 114.6 19.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1228 PF06779.9 EFW99654.1 - 0.0033 17.3 7.5 0.23 11.4 0.3 3.7 3 0 0 3 3 3 3 Protein of unknown function (DUF1228) BCS1_N PF08740.6 EFW99655.1 - 9.3e-31 106.8 0.0 9.9e-17 61.1 0.0 2.4 1 1 1 2 2 2 2 BCS1 N terminal Brix PF04427.13 EFW99655.1 - 1.9e-24 86.3 0.0 2.9e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Brix domain AAA PF00004.24 EFW99655.1 - 1.1e-17 64.5 0.0 1.9e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFW99655.1 - 3.2e-05 24.7 0.0 0.00011 22.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 EFW99655.1 - 4e-05 23.1 0.0 8.7e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain APG6 PF04111.7 EFW99655.1 - 0.002 17.2 0.1 0.0031 16.6 0.1 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 AAA_16 PF13191.1 EFW99655.1 - 0.0023 17.9 0.1 0.02 14.8 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 EFW99655.1 - 0.0041 16.9 0.0 0.013 15.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EFW99655.1 - 0.0046 15.9 0.0 0.0083 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 EFW99655.1 - 0.0052 16.9 0.0 0.018 15.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.7 EFW99655.1 - 0.025 13.6 0.0 0.049 12.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 EFW99655.1 - 0.03 13.4 0.0 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.1 EFW99655.1 - 0.037 13.6 0.1 0.09 12.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFW99655.1 - 0.037 13.7 0.1 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.1 EFW99655.1 - 0.038 13.9 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFW99655.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFW99655.1 - 0.055 13.1 0.0 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 Archaeal ATPase AAA_19 PF13245.1 EFW99655.1 - 0.058 13.1 0.0 0.25 11.1 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain AAA_29 PF13555.1 EFW99655.1 - 0.067 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.14 EFW99655.1 - 0.077 12.4 0.0 0.63 9.4 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 EFW99655.1 - 0.096 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFW99655.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter KaiC PF06745.8 EFW99655.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 KaiC ATP_bind_1 PF03029.12 EFW99655.1 - 0.16 11.4 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Miro PF08477.8 EFW99655.1 - 0.19 12.2 0.0 0.65 10.5 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein RNA_helicase PF00910.17 EFW99655.1 - 0.22 11.7 0.0 0.46 10.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.1 EFW99655.1 - 0.31 11.3 0.0 0.53 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain PHD PF00628.24 EFW99656.1 - 7.1e-10 38.4 5.3 1.3e-09 37.5 3.7 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 EFW99656.1 - 1.4e-05 24.2 1.9 2.6e-05 23.4 1.3 1.4 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.1 EFW99656.1 - 0.00062 19.4 1.6 0.00062 19.4 1.1 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-PHD-like PF15446.1 EFW99656.1 - 0.0048 16.2 0.4 0.011 15.0 0.2 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain Ribosomal_S24e PF01282.14 EFW99659.1 - 8.7e-35 118.3 0.0 1.5e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e Sugar_tr PF00083.19 EFW99660.1 - 2.3e-71 240.7 27.9 2.3e-71 240.7 19.3 3.7 3 1 0 3 3 3 1 Sugar (and other) transporter AA_permease_2 PF13520.1 EFW99660.1 - 9.3e-39 133.1 38.4 9.3e-39 133.1 26.6 3.9 3 2 0 3 3 3 2 Amino acid permease MFS_1 PF07690.11 EFW99660.1 - 1.4e-30 106.2 26.5 1.4e-30 106.2 18.4 4.5 3 2 1 4 4 4 3 Major Facilitator Superfamily AA_permease PF00324.16 EFW99660.1 - 5.4e-10 38.2 31.9 5.4e-10 38.2 22.1 3.0 3 1 0 3 3 3 1 Amino acid permease Ank_2 PF12796.2 EFW99661.1 - 1.3e-18 67.1 0.3 1.2e-06 28.8 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99661.1 - 2.3e-17 61.8 0.1 8.6e-06 25.3 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 EFW99661.1 - 1e-15 57.7 0.3 4.1e-07 30.3 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFW99661.1 - 2.1e-15 56.3 0.2 5e-07 29.7 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99661.1 - 1.3e-11 43.5 0.1 0.0093 16.1 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Actin PF00022.14 EFW99663.1 - 3.4e-117 391.2 0.0 4.1e-117 390.9 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EFW99663.1 - 0.0011 17.5 0.0 0.0044 15.6 0.0 1.8 1 1 0 1 1 1 1 MreB/Mbl protein GTP_cyclohydro2 PF00925.15 EFW99664.1 - 7.5e-56 188.0 0.0 3.7e-53 179.2 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II DUF1325 PF07039.6 EFW99665.1 - 1.1e-26 92.9 0.7 1.6e-26 92.4 0.0 1.6 2 0 0 2 2 2 1 SGF29 tudor-like domain DUF1296 PF06972.6 EFW99665.1 - 0.067 13.1 0.1 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) Pro-kuma_activ PF09286.6 EFW99666.1 - 8.9e-36 123.0 0.0 1.4e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFW99666.1 - 1.9e-09 37.1 0.0 3.2e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Subtilase family DUF3228 PF11539.3 EFW99666.1 - 0.24 10.4 0.0 0.43 9.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) Arf PF00025.16 EFW99667.1 - 2.7e-74 248.1 0.3 3.1e-74 247.9 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EFW99667.1 - 3.3e-13 49.3 0.0 3.6e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EFW99667.1 - 9.3e-13 47.6 2.3 1.6e-09 36.9 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EFW99667.1 - 4e-11 42.4 0.1 5e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EFW99667.1 - 5e-11 42.1 0.0 6.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 EFW99667.1 - 1e-07 32.4 0.0 1.5e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFW99667.1 - 0.00037 20.4 0.0 0.00048 20.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 EFW99667.1 - 0.04 12.9 0.3 0.068 12.2 0.0 1.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Pkinase PF00069.20 EFW99669.1 - 7.7e-62 208.7 0.0 1.2e-61 208.1 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99669.1 - 5.5e-31 107.5 0.0 2.6e-30 105.3 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99669.1 - 0.0047 15.9 0.0 0.0076 15.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFW99669.1 - 0.012 15.3 0.0 0.16 11.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family PMI_typeI PF01238.16 EFW99671.1 - 1.1e-73 248.3 0.0 1.3e-73 248.1 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I DUF2894 PF11445.3 EFW99672.1 - 0.24 11.6 4.7 0.48 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) Histone PF00125.19 EFW99674.1 - 3.6e-31 107.0 0.4 5.8e-31 106.4 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EFW99674.1 - 4.1e-06 26.8 0.0 6.2e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EFW99674.1 - 0.004 17.1 0.3 0.0074 16.3 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EFW99674.1 - 0.014 15.1 0.1 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.19 EFW99675.1 - 1e-14 54.3 0.1 1.2e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 EFW99675.1 - 0.00014 21.7 0.1 0.00021 21.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 EFW99675.1 - 0.00015 21.8 0.1 0.0002 21.4 0.0 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EFW99675.1 - 0.0005 20.0 0.1 0.00094 19.1 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EFW99675.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.3 1 1 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 EFW99675.1 - 0.036 13.3 0.0 0.036 13.3 0.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T MFS_1 PF07690.11 EFW99676.1 - 5.4e-41 140.4 58.7 1.2e-37 129.4 26.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_3 PF00202.16 EFW99677.1 - 1.5e-79 267.3 0.1 2.1e-79 266.8 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-III FAD_binding_3 PF01494.14 EFW99677.1 - 1.8e-60 204.8 0.5 3.3e-59 200.7 0.4 2.3 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 EFW99677.1 - 3.6e-13 49.4 0.0 7.8e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.5 EFW99677.1 - 0.0011 17.8 0.0 0.0025 16.7 0.0 1.5 1 0 0 1 1 1 1 Squalene epoxidase Cupin_2 PF07883.6 EFW99678.1 - 5.4e-09 35.4 0.0 8.9e-09 34.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 EFW99678.1 - 0.075 12.4 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Cupin BBE PF08031.7 EFW99679.1 - 9.1e-10 38.3 0.0 1.1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Berberine and berberine like Fungal_trans PF04082.13 EFW99680.1 - 1.6e-18 66.5 0.3 1.2e-17 63.6 0.1 2.0 1 1 0 2 2 2 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.21 EFW99682.1 - 1.8e-86 289.7 0.3 4.9e-86 288.3 0.2 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.23 EFW99682.1 - 1.8e-69 234.1 0.2 3.1e-69 233.3 0.2 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Acyl_transf_1 PF00698.16 EFW99682.1 - 2.7e-55 187.9 0.9 4.8e-55 187.1 0.6 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 EFW99682.1 - 2.9e-39 133.5 0.8 2.9e-39 133.5 0.6 3.1 4 0 0 4 4 4 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFW99682.1 - 6.1e-16 58.4 0.1 9e-09 35.4 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFW99682.1 - 2.1e-14 54.1 0.2 2.1e-14 54.1 0.2 3.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Thiolase_N PF00108.18 EFW99682.1 - 2.2e-08 33.4 3.6 2.6e-07 29.9 0.1 2.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain DKCLD PF08068.7 EFW99683.1 - 4.4e-28 96.9 0.1 3.3e-27 94.1 0.0 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 EFW99683.1 - 2.3e-22 79.7 4.0 1.9e-20 73.5 0.2 3.5 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 EFW99683.1 - 3.1e-21 74.8 0.6 6.3e-21 73.8 0.4 1.5 1 0 0 1 1 1 1 PUA domain Med19 PF10278.4 EFW99683.1 - 2.6 7.6 9.0 4.8 6.8 6.2 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CDP-OH_P_transf PF01066.16 EFW99684.1 - 1.3e-13 51.1 2.3 1.3e-13 51.1 1.6 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase eIF-3c_N PF05470.7 EFW99685.1 - 1.8e-174 581.1 18.3 1.8e-174 581.1 12.7 3.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 EFW99685.1 - 6.6e-13 48.8 0.1 3.4e-12 46.5 0.0 2.4 2 0 0 2 2 2 1 PCI domain Nop14 PF04147.7 EFW99685.1 - 0.01 13.8 22.5 0.016 13.1 15.6 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 EFW99685.1 - 0.71 7.8 19.7 1.1 7.2 13.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 EFW99685.1 - 1.1 8.5 19.0 1.9 7.8 13.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAPPC10 PF12584.3 EFW99686.1 - 4.3e-27 94.4 0.0 8.5e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 PYC_OADA PF02436.13 EFW99686.1 - 0.19 11.1 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 Conserved carboxylase domain BRO1 PF03097.13 EFW99688.1 - 0.0013 17.6 0.8 0.0035 16.1 0.6 1.7 1 1 0 1 1 1 1 BRO1-like domain eIF2A PF08662.6 EFW99689.1 - 1.8e-38 132.2 1.7 1e-36 126.4 0.1 3.5 3 2 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A RRM_6 PF14259.1 EFW99689.1 - 1.9e-05 24.5 0.0 4.5e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFW99689.1 - 5e-05 22.8 0.0 0.0001 21.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 EFW99689.1 - 0.00085 19.1 0.6 1.8 8.5 0.0 4.3 5 0 0 5 5 5 1 WD domain, G-beta repeat RRM_5 PF13893.1 EFW99689.1 - 0.00098 18.9 0.0 0.0021 17.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L30_N PF08079.7 EFW99690.1 - 7.8e-24 83.4 19.8 1.3e-23 82.7 13.7 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.15 EFW99690.1 - 3.2e-18 65.0 1.4 3.2e-18 65.0 1.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e ERCC4 PF02732.10 EFW99690.1 - 0.032 14.0 0.4 0.062 13.0 0.3 1.6 1 0 0 1 1 1 0 ERCC4 domain DUF4520 PF15016.1 EFW99691.1 - 0.096 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) C2 PF00168.25 EFW99692.1 - 1.4e-12 47.2 0.2 3e-12 46.2 0.1 1.6 1 0 0 1 1 1 1 C2 domain zf-MYND PF01753.13 EFW99693.1 - 8.4e-08 31.9 19.6 2.4e-07 30.4 13.6 1.9 1 0 0 1 1 1 1 MYND finger BAF1_ABF1 PF04684.8 EFW99693.1 - 0.00031 19.7 1.3 0.00031 19.7 0.9 2.0 3 0 0 3 3 3 1 BAF1 / ABF1 chromatin reorganising factor Ldl_recept_b PF00058.12 EFW99694.1 - 0.0077 16.5 5.7 1 9.7 0.1 5.3 6 2 0 6 6 6 1 Low-density lipoprotein receptor repeat class B SGL PF08450.7 EFW99694.1 - 0.058 12.7 0.0 0.72 9.1 0.0 2.5 2 1 1 3 3 3 0 SMP-30/Gluconolaconase/LRE-like region DUF3445 PF11927.3 EFW99695.1 - 1.7e-57 194.6 0.0 4.8e-43 147.3 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3445) Mito_carr PF00153.22 EFW99696.1 - 1.2e-59 198.0 0.9 4.4e-21 74.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein RhoGAP PF00620.22 EFW99697.1 - 1.6e-28 99.2 0.0 2.7e-28 98.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DUF4124 PF13511.1 EFW99697.1 - 0.94 9.5 8.1 2.9 8.0 1.2 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4124) Scytalone_dh PF02982.9 EFW99698.1 - 1.2e-87 291.5 1.1 1.4e-87 291.2 0.8 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.1 EFW99698.1 - 4e-07 29.9 1.7 6e-07 29.4 1.2 1.2 1 0 0 1 1 1 1 SnoaL-like domain Aminotran_4 PF01063.14 EFW99699.1 - 1.4e-12 47.5 0.0 1.6e-11 44.0 0.0 2.0 1 1 1 2 2 2 1 Aminotransferase class IV Plug_translocon PF10559.4 EFW99699.1 - 0.093 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Plug domain of Sec61p HNH_2 PF13391.1 EFW99700.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 0 HNH endonuclease Band_7 PF01145.20 EFW99701.1 - 5e-09 36.3 0.0 5e-09 36.3 0.0 3.2 2 2 0 2 2 2 1 SPFH domain / Band 7 family Oxysterol_BP PF01237.13 EFW99701.1 - 6.4 5.1 7.6 6.4 5.1 1.7 2.3 1 1 1 2 2 2 0 Oxysterol-binding protein Leo1 PF04004.8 EFW99702.1 - 1.8e-31 109.1 0.0 1.8e-31 109.1 0.0 2.0 2 0 0 2 2 2 1 Leo1-like protein DUF3336 PF11815.3 EFW99702.1 - 8.5e-26 90.1 0.0 1.9e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EFW99702.1 - 4.2e-11 43.1 0.6 4.2e-11 43.1 0.4 2.1 2 0 0 2 2 2 1 Patatin-like phospholipase HgmA PF04209.8 EFW99703.1 - 6.7e-174 578.2 0.0 7.7e-174 578.0 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Actin PF00022.14 EFW99704.1 - 2.3e-159 530.0 0.0 2.6e-159 529.8 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 EFW99704.1 - 0.04 14.3 0.0 0.11 12.9 0.0 1.7 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Proteasome PF00227.21 EFW99705.1 - 1.9e-43 147.9 0.2 2.9e-29 101.7 0.0 2.5 3 0 0 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.4 EFW99705.1 - 2.5e-12 45.8 0.1 1.6e-11 43.2 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature HSF_DNA-bind PF00447.12 EFW99706.1 - 1.1e-33 115.4 0.2 2e-33 114.6 0.1 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.19 EFW99706.1 - 1.2e-20 73.5 0.1 2.3e-20 72.6 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain CENP-Q PF13094.1 EFW99706.1 - 0.025 14.6 0.7 0.047 13.7 0.5 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1759 PF03564.10 EFW99706.1 - 0.045 13.5 0.5 0.11 12.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) CENP-H PF05837.7 EFW99706.1 - 0.36 11.0 3.0 0.71 10.0 2.1 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FMO-like PF00743.14 EFW99707.1 - 4e-20 71.5 0.0 2.9e-06 25.7 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFW99707.1 - 1.4e-19 71.0 0.0 2e-10 41.0 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFW99707.1 - 1.2e-09 37.5 0.0 9.3e-05 21.4 0.0 3.1 3 0 0 3 3 3 3 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFW99707.1 - 5.6e-08 32.6 0.2 0.0077 16.0 0.0 3.4 3 0 0 3 3 3 3 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFW99707.1 - 4.6e-06 26.5 0.0 5e-05 23.2 0.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFW99707.1 - 1.2e-05 25.2 0.0 0.68 9.7 0.0 3.2 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFW99707.1 - 0.0019 17.3 0.1 0.0038 16.3 0.0 1.5 2 0 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.19 EFW99707.1 - 0.016 14.3 0.0 8.5 5.3 0.0 3.1 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase HI0933_like PF03486.9 EFW99707.1 - 0.052 12.0 0.1 0.32 9.4 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein UCH PF00443.24 EFW99708.1 - 2.1e-56 190.9 2.9 2.7e-56 190.6 2.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFW99708.1 - 2.4e-34 119.1 1.3 3.2e-34 118.7 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EFW99708.1 - 2.2e-06 27.6 0.8 2.2e-06 27.6 0.5 2.7 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_3 PF14369.1 EFW99708.1 - 0.6 10.1 0.1 0.6 10.1 0.0 3.9 4 0 0 4 4 4 0 zinc-finger NAD_binding_10 PF13460.1 EFW99709.1 - 1.8e-16 60.6 0.0 2.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFW99709.1 - 3.7e-15 55.8 0.0 4.7e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 EFW99709.1 - 1.2e-14 54.3 0.1 2.5e-14 53.2 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFW99709.1 - 5.4e-11 41.7 0.0 7.8e-11 41.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EFW99709.1 - 1.5e-09 37.2 0.0 7.3e-09 34.9 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EFW99709.1 - 0.00011 21.2 0.3 0.023 13.6 0.2 3.0 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EFW99709.1 - 0.00051 19.9 0.0 0.0041 17.0 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFW99709.1 - 0.0067 16.1 0.0 2.6 7.6 0.0 2.5 3 0 0 3 3 3 2 KR domain Saccharop_dh PF03435.13 EFW99709.1 - 0.0089 15.0 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase ApbA PF02558.11 EFW99709.1 - 0.012 15.0 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.10 EFW99709.1 - 0.07 12.0 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HIM1 PF08732.5 EFW99709.1 - 0.091 11.2 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 HIM1 SnoaL_3 PF13474.1 EFW99709.1 - 0.12 12.4 0.1 5.9 6.9 0.0 2.4 2 0 0 2 2 2 0 SnoaL-like domain GST_N_3 PF13417.1 EFW99710.1 - 4.2e-18 65.3 0.1 1.1e-17 64.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFW99710.1 - 5.4e-13 48.7 0.1 1.1e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFW99710.1 - 7.1e-09 35.7 0.0 1.4e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.19 EFW99710.1 - 0.00096 19.0 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin ArgJ PF01960.13 EFW99713.1 - 6.2e-144 479.1 0.1 7.6e-144 478.8 0.0 1.1 1 0 0 1 1 1 1 ArgJ family E1-E2_ATPase PF00122.15 EFW99714.1 - 1.7e-71 239.8 0.0 3e-71 239.1 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFW99714.1 - 9.7e-44 149.0 0.5 1.9e-43 148.0 0.4 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFW99714.1 - 4.4e-29 102.4 0.0 2.5e-28 99.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFW99714.1 - 5.6e-17 60.9 0.1 1.1e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 EFW99714.1 - 5e-13 49.6 0.0 1.3e-12 48.3 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFW99714.1 - 2.4e-12 46.6 0.0 4.5e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFW99714.1 - 5.9e-05 22.7 0.9 0.00011 21.8 0.6 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase B-block_TFIIIC PF04182.7 EFW99715.1 - 9.3e-14 51.0 0.0 2.4e-13 49.7 0.0 1.7 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC TFIIA PF03153.8 EFW99715.1 - 0.026 14.4 0.1 0.026 14.4 0.1 3.3 3 1 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.27 EFW99716.1 - 1.1e-86 281.9 25.2 1.7e-12 46.7 0.4 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat eIF2A PF08662.6 EFW99716.1 - 1e-07 31.8 0.0 0.0044 16.7 0.0 3.8 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EFW99716.1 - 1.5e-06 26.6 4.8 0.16 10.0 0.0 4.5 4 1 0 4 4 4 3 Nucleoporin Nup120/160 TFIIIC_delta PF12657.2 EFW99716.1 - 0.00022 20.9 4.1 0.74 9.5 0.0 4.4 3 2 2 5 5 5 2 Transcription factor IIIC subunit delta N-term PD40 PF07676.7 EFW99716.1 - 0.00037 20.0 0.8 0.77 9.4 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat NLE PF08154.7 EFW99716.1 - 0.0056 16.6 0.0 0.0098 15.8 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nbas_N PF15492.1 EFW99716.1 - 0.017 14.2 0.4 7.3 5.6 0.0 3.6 2 2 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.16 EFW99716.1 - 0.04 12.5 0.2 3 6.3 0.0 2.8 3 1 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_3 PF13570.1 EFW99716.1 - 8.9 6.7 8.6 12 6.2 0.4 3.6 3 1 1 4 4 4 0 PQQ-like domain CHB_HEX_C_1 PF13290.1 EFW99717.1 - 5.1e-09 35.7 4.3 5.1e-09 35.7 3.0 3.7 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C PF03174.8 EFW99717.1 - 6.5e-09 35.5 13.6 6.5e-08 32.2 2.9 3.8 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 EFW99717.1 - 9.4e-09 35.2 14.6 4.8e-08 32.9 3.5 3.3 3 0 0 3 3 3 2 Fn3 associated F5_F8_type_C PF00754.20 EFW99717.1 - 3.7e-08 33.2 3.3 3.9e-07 29.9 0.1 3.7 5 0 0 5 5 5 1 F5/8 type C domain Peptidase_C48 PF02902.14 EFW99718.1 - 1.4e-09 37.9 0.1 2.4e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF3381 PF11861.3 EFW99719.1 - 1.8 8.0 6.1 3.1 7.3 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Pro-kuma_activ PF09286.6 EFW99720.1 - 9.9e-38 129.3 0.1 3.1e-37 127.7 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Las1 PF04031.8 EFW99722.1 - 4.1e-58 195.4 0.6 6.4e-58 194.7 0.4 1.3 1 0 0 1 1 1 1 Las1-like CoA_transf_3 PF02515.12 EFW99724.1 - 3e-32 111.3 0.0 2.4e-29 101.9 0.0 2.4 2 0 0 2 2 2 2 CoA-transferase family III SKG6 PF08693.5 EFW99726.1 - 0.00015 21.0 0.0 0.0003 20.0 0.0 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.1 EFW99726.1 - 0.036 13.5 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Glyoxalase_2 PF12681.2 EFW99727.1 - 0.00018 22.0 0.1 0.00028 21.4 0.1 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 EFW99727.1 - 0.039 13.9 0.0 0.065 13.2 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Fe-S_biosyn PF01521.15 EFW99728.1 - 2.2e-11 43.6 0.0 9.7e-05 22.2 0.0 2.2 1 1 1 2 2 2 2 Iron-sulphur cluster biosynthesis ubiquitin PF00240.18 EFW99729.1 - 8e-25 86.0 0.1 8.9e-25 85.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EFW99729.1 - 1.7e-15 56.4 0.2 1.8e-15 56.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EFW99729.1 - 5.9e-05 23.2 0.1 0.00017 21.7 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain bZIP_1 PF00170.16 EFW99730.1 - 5.9e-07 29.3 12.2 5.9e-07 29.3 8.4 2.5 3 0 0 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.12 EFW99730.1 - 1.7e-06 28.1 12.3 1.7e-06 28.1 8.5 2.6 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_2 PF07716.10 EFW99730.1 - 4.1e-05 23.3 15.8 0.00011 21.9 8.5 2.9 2 1 0 2 2 2 1 Basic region leucine zipper Endotoxin_N PF03945.9 EFW99730.1 - 0.21 10.9 3.6 0.42 9.9 2.5 1.4 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain Pyr_redox_3 PF13738.1 EFW99731.1 - 1.7e-25 90.2 0.0 4.1e-25 89.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFW99731.1 - 1.1e-08 33.7 0.0 1.8e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFW99731.1 - 6e-07 29.4 0.0 1.8e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFW99731.1 - 6.9e-07 28.4 0.0 5.1e-05 22.3 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFW99731.1 - 2.3e-05 24.3 0.0 0.0018 18.2 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFW99731.1 - 6.8e-05 22.6 1.5 0.0024 17.6 0.1 3.3 3 2 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.12 EFW99731.1 - 0.0083 15.2 0.0 0.067 12.2 0.0 2.0 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.9 EFW99731.1 - 0.094 11.1 0.1 0.15 10.4 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein adh_short PF00106.20 EFW99732.1 - 1.8e-10 41.0 0.4 7.8e-10 38.9 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW99732.1 - 4.3e-05 23.3 0.0 0.00012 21.9 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFW99732.1 - 0.0027 17.3 0.2 0.082 12.5 0.1 2.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFW99732.1 - 0.0032 16.9 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 EFW99732.1 - 0.035 13.9 0.1 0.1 12.3 0.1 1.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PRA1 PF03208.14 EFW99733.1 - 7.9e-38 129.2 0.5 1.2e-37 128.5 0.3 1.3 1 0 0 1 1 1 1 PRA1 family protein Rep_4 PF05797.6 EFW99733.1 - 0.74 8.4 6.5 1.3 7.6 4.5 1.2 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) zf-DHHC PF01529.15 EFW99734.1 - 1e-39 135.7 2.6 2.1e-39 134.7 1.8 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase zf-C2H2_jaz PF12171.3 EFW99734.1 - 0.00071 19.6 1.0 0.33 11.1 0.1 3.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EFW99734.1 - 0.00076 19.6 33.1 0.043 14.1 0.2 6.4 6 0 0 6 6 6 4 Zinc finger, C2H2 type DZR PF12773.2 EFW99734.1 - 0.054 13.3 16.9 0.39 10.5 4.3 3.5 3 0 0 3 3 3 0 Double zinc ribbon Yip1 PF04893.12 EFW99734.1 - 0.056 12.9 5.5 0.6 9.5 1.3 2.3 2 0 0 2 2 2 0 Yip1 domain zf-C2H2_6 PF13912.1 EFW99734.1 - 0.097 12.6 0.2 0.097 12.6 0.1 6.3 7 0 0 7 7 7 0 C2H2-type zinc finger DctQ PF04290.7 EFW99734.1 - 0.25 11.0 11.0 0.089 12.5 0.7 2.6 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3176 PF11374.3 EFW99736.1 - 9.1e-20 70.5 8.7 1.5e-19 69.8 6.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) AA_permease PF00324.16 EFW99737.1 - 2.2e-80 270.3 40.0 2.6e-80 270.0 27.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFW99737.1 - 1.3e-22 79.9 48.1 1.7e-22 79.6 33.3 1.1 1 0 0 1 1 1 1 Amino acid permease Ebp2 PF05890.7 EFW99738.1 - 9.2e-85 284.2 13.0 9.2e-85 284.2 9.0 2.8 1 1 2 3 3 3 1 Eukaryotic rRNA processing protein EBP2 Bac_luciferase PF00296.15 EFW99739.1 - 7.4e-61 205.9 1.4 1.1e-60 205.3 1.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase GPI-anchored PF10342.4 EFW99740.1 - 7.2e-09 36.0 3.8 1.2e-08 35.2 1.9 1.8 1 1 1 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Paramyxo_PNT PF13825.1 EFW99740.1 - 0.77 8.9 4.0 0.97 8.5 2.7 1.1 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus DUF1932 PF09130.6 EFW99741.1 - 1.2e-15 57.0 0.1 3.5e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) F420_oxidored PF03807.12 EFW99741.1 - 2.6e-08 34.1 0.1 7e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 EFW99741.1 - 8.8e-06 25.6 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 EFW99741.1 - 0.0045 16.1 0.0 0.0081 15.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_transf_90 PF05686.7 EFW99742.1 - 3.1e-13 49.1 1.8 1.1e-10 40.8 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferase family 90 MFS_1 PF07690.11 EFW99743.1 - 2.7e-17 62.5 28.3 1.4e-13 50.3 14.5 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily PITH PF06201.8 EFW99744.1 - 4.3e-40 136.9 0.0 5.6e-40 136.6 0.0 1.1 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.15 EFW99744.1 - 5.4e-23 80.6 0.0 9.5e-23 79.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFW99744.1 - 1.3e-07 31.7 0.0 3.3e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFW99744.1 - 3.1e-06 27.2 0.5 0.00072 19.6 0.0 2.6 2 1 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 EFW99744.1 - 0.0044 16.6 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family HyaE PF07449.6 EFW99744.1 - 0.027 14.3 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.1 EFW99744.1 - 0.031 14.2 0.0 0.071 13.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Serglycin PF04360.7 EFW99744.1 - 0.061 13.0 0.1 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Serglycin Redoxin PF08534.5 EFW99744.1 - 0.15 11.5 1.2 0.72 9.3 0.1 2.3 2 1 1 3 3 3 0 Redoxin Pkinase PF00069.20 EFW99745.1 - 1.2e-63 214.7 0.0 1.4e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99745.1 - 1.4e-25 89.8 0.0 1.8e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99745.1 - 1.6e-07 30.6 0.0 8.4e-07 28.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 EFW99745.1 - 0.0009 19.0 0.3 0.013 15.2 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFW99745.1 - 0.057 12.9 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase P34-Arc PF04045.9 EFW99746.1 - 3.7e-99 330.9 0.1 4.5e-99 330.6 0.1 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Orn_Arg_deC_N PF02784.11 EFW99747.1 - 1.1e-79 267.2 0.0 1.5e-79 266.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 EFW99747.1 - 1.1e-28 99.3 0.0 2e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.19 EFW99747.1 - 0.061 12.5 0.0 0.16 11.1 0.0 1.8 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Pex2_Pex12 PF04757.9 EFW99748.1 - 2e-38 132.1 0.1 2.7e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 EFW99748.1 - 2.5e-11 43.2 9.5 3.9e-11 42.5 6.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFW99748.1 - 6.2e-11 42.1 8.5 9.3e-11 41.5 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFW99748.1 - 2.5e-10 39.8 6.4 3.7e-10 39.2 4.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFW99748.1 - 1.4e-09 37.4 6.0 2.1e-09 36.9 4.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFW99748.1 - 9.5e-08 31.6 5.5 1.4e-07 31.0 3.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EFW99748.1 - 7.6e-07 28.9 8.5 1.3e-06 28.1 5.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFW99748.1 - 8e-05 22.2 1.9 0.00016 21.3 1.3 1.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 EFW99748.1 - 0.00014 21.5 3.4 0.00027 20.6 2.3 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 EFW99748.1 - 0.00041 20.4 7.3 0.001 19.1 5.1 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger U-box PF04564.10 EFW99748.1 - 0.006 16.5 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 EFW99748.1 - 0.02 14.4 0.9 0.034 13.6 0.7 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 EFW99748.1 - 0.16 11.5 7.3 0.27 10.8 5.0 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.16 EFW99748.1 - 0.37 10.6 4.1 0.74 9.7 2.9 1.5 1 0 0 1 1 1 0 IBR domain zf-Apc11 PF12861.2 EFW99748.1 - 0.47 10.3 3.7 0.4 10.5 1.4 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Cerato-platanin PF07249.7 EFW99750.1 - 2.4e-05 24.2 1.9 2.8e-05 24.0 0.2 1.9 2 0 0 2 2 2 1 Cerato-platanin AF-4 PF05110.8 EFW99750.1 - 0.33 8.7 9.2 0.51 8.1 6.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ank_2 PF12796.2 EFW99751.1 - 2.3e-80 265.0 13.0 3.1e-23 81.9 0.2 5.7 2 1 4 6 6 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99751.1 - 6.7e-62 202.3 12.7 5.5e-07 29.0 0.0 8.9 9 0 0 9 9 8 8 Ankyrin repeat Ank_3 PF13606.1 EFW99751.1 - 1.8e-50 163.8 1.3 8.8e-05 22.3 0.0 9.8 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.1 EFW99751.1 - 1.4e-36 124.2 7.6 1.2e-08 35.2 0.0 7.5 4 2 3 8 8 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFW99751.1 - 2.5e-35 119.7 22.3 3.3e-09 36.7 0.1 8.4 1 1 7 8 8 8 8 Ankyrin repeats (many copies) NACHT PF05729.7 EFW99751.1 - 8.7e-07 28.7 0.9 4.2e-06 26.5 0.1 2.6 2 0 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.9 EFW99751.1 - 6.4e-06 25.3 0.0 0.02 13.9 0.0 2.3 2 0 0 2 2 2 2 KAP family P-loop domain AAA_22 PF13401.1 EFW99751.1 - 1.3e-05 25.3 0.2 0.0008 19.5 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EFW99751.1 - 2.3e-05 24.4 0.5 0.00017 21.6 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 EFW99751.1 - 0.023 14.8 0.1 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 EFW99751.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Arch_ATPase PF01637.13 EFW99751.1 - 0.079 12.6 0.3 0.73 9.4 0.2 2.3 1 1 0 1 1 1 0 Archaeal ATPase ArgK PF03308.11 EFW99751.1 - 0.16 10.7 0.0 0.29 9.8 0.0 1.3 1 0 0 1 1 1 0 ArgK protein ThiF PF00899.16 EFW99752.1 - 1.1e-39 135.4 0.0 1.8e-39 134.6 0.0 1.4 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 EFW99752.1 - 9.9e-20 69.9 0.1 2.7e-19 68.5 0.1 1.8 1 1 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 EFW99752.1 - 3.1e-09 37.1 0.0 6.6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.15 EFW99752.1 - 0.0004 20.5 0.1 0.0059 16.6 0.1 2.2 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 EFW99752.1 - 0.028 14.6 0.0 0.054 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.14 EFW99752.1 - 0.097 11.6 2.1 0.28 10.2 0.9 1.9 2 0 0 2 2 2 0 FAD binding domain DUF1343 PF07075.6 EFW99753.1 - 1.7e-116 389.0 0.0 2e-116 388.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1343) Fungal_trans PF04082.13 EFW99754.1 - 4.5e-11 42.1 0.1 6.5e-11 41.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Urm1 PF09138.6 EFW99756.1 - 9.4e-33 112.2 0.0 1.1e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 EFW99756.1 - 1.5e-05 25.2 0.0 2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 ThiS family N6-adenineMlase PF10237.4 EFW99757.1 - 1.8e-53 180.4 0.0 2.3e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase tRNA-synt_1 PF00133.17 EFW99758.1 - 4.6e-201 668.9 0.0 3.3e-200 666.0 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EFW99758.1 - 2e-31 108.8 0.5 4.1e-31 107.7 0.4 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EFW99758.1 - 9.6e-13 47.5 0.4 3e-05 22.8 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 EFW99758.1 - 1.9e-10 40.3 0.1 4.5e-07 29.3 0.0 2.7 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1b PF00579.20 EFW99758.1 - 0.067 12.3 0.0 0.19 10.8 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) tRNA-synt_1e PF01406.14 EFW99758.1 - 0.14 11.2 0.0 0.35 9.9 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain HET PF06985.6 EFW99759.1 - 3.4e-20 72.6 0.0 8.2e-20 71.3 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DnaJ PF00226.26 EFW99760.1 - 4.2e-19 68.0 2.3 7.6e-19 67.2 1.6 1.4 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.8 EFW99760.1 - 0.018 15.0 2.1 0.026 14.5 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Sigma70_ECF PF07638.6 EFW99760.1 - 0.081 12.5 0.1 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 ECF sigma factor FLO_LFY PF01698.11 EFW99760.1 - 0.11 11.3 0.4 0.14 10.9 0.2 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Gly-zipper_OmpA PF13436.1 EFW99760.1 - 0.2 11.2 4.4 0.44 10.2 3.1 1.6 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Zn_clus PF00172.13 EFW99761.1 - 2.2 8.2 14.4 3.7 7.5 10.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.24 EFW99764.1 - 1e-35 122.7 0.0 1e-34 119.4 0.0 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFW99764.1 - 6e-24 83.7 0.0 1.3e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW99764.1 - 0.00054 19.8 0.1 0.14 12.0 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4106 PF13388.1 EFW99764.1 - 0.16 10.9 3.3 0.23 10.3 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) CPSase_L_D2 PF02786.12 EFW99765.1 - 1.5e-81 272.6 0.4 2.4e-81 272.0 0.2 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 EFW99765.1 - 4.5e-67 225.2 0.0 7.5e-67 224.5 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 EFW99765.1 - 1.3e-34 118.5 0.0 2.8e-34 117.5 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EFW99765.1 - 2.7e-31 107.7 0.0 7.9e-31 106.2 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 EFW99765.1 - 4e-26 92.1 0.0 6.5e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 HMGL-like ATP-grasp_4 PF13535.1 EFW99765.1 - 4.2e-20 72.2 0.2 1.1e-19 70.8 0.1 1.7 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl PF00364.17 EFW99765.1 - 5.9e-19 67.4 2.6 8.6e-19 66.9 0.7 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 EFW99765.1 - 3.3e-15 55.6 0.0 2.7e-14 52.6 0.0 2.2 2 1 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFW99765.1 - 2.4e-11 43.4 0.0 4.5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.1 EFW99765.1 - 6e-09 35.4 3.1 2.9e-06 26.8 0.0 2.9 2 1 1 3 3 2 2 Biotin-lipoyl like ATP-grasp PF02222.17 EFW99765.1 - 1.3e-08 34.3 0.1 2.5e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EFW99765.1 - 3.1e-06 26.7 0.0 2.3e-05 23.9 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EFW99765.1 - 2.5e-05 24.1 0.0 5.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 EFW99765.1 - 2.7e-05 23.6 0.4 0.0035 16.6 0.0 2.8 3 0 0 3 3 3 1 HlyD family secretion protein HlyD_2 PF12700.2 EFW99765.1 - 0.0026 16.9 0.0 0.44 9.6 0.0 2.2 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_3 PF13437.1 EFW99765.1 - 0.0037 17.5 0.1 6.2 7.2 0.0 3.1 3 0 0 3 3 3 2 HlyD family secretion protein GARS_A PF01071.14 EFW99765.1 - 0.011 15.3 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PYNP_C PF07831.8 EFW99765.1 - 0.33 10.4 2.1 1.7 8.1 0.0 2.9 2 1 1 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain Ank_2 PF12796.2 EFW99766.1 - 4.3e-17 62.2 0.1 3.7e-11 43.2 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99766.1 - 4.1e-13 48.4 0.0 0.0011 18.6 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 EFW99766.1 - 7.6e-06 25.9 0.0 0.016 15.4 0.0 3.9 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99766.1 - 3.7e-05 23.5 0.0 0.39 11.0 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 EFW99766.1 - 0.00011 22.5 0.0 0.14 12.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) VWA_2 PF13519.1 EFW99766.1 - 0.0058 16.7 0.0 0.028 14.5 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 EFW99766.1 - 0.043 13.6 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 vWA found in TerF C terminus HATPase_c_3 PF13589.1 EFW99767.1 - 2.2e-06 27.3 0.1 5.7e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3883 PF13020.1 EFW99767.1 - 0.00014 21.5 0.0 0.00029 20.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) CENP-F_leu_zip PF10473.4 EFW99767.1 - 0.032 14.1 8.5 0.07 12.9 5.9 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 EFW99767.1 - 0.11 12.1 2.5 0.22 11.0 1.8 1.4 1 0 0 1 1 1 0 IncA protein YlqD PF11068.3 EFW99767.1 - 0.22 11.5 4.7 0.37 10.8 1.2 2.7 3 0 0 3 3 3 0 YlqD protein DUF972 PF06156.8 EFW99767.1 - 0.4 11.0 2.8 1.3 9.4 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF972) TBPIP PF07106.8 EFW99767.1 - 0.58 9.6 3.4 1.3 8.5 2.3 1.5 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) NACHT PF05729.7 EFW99768.1 - 2.9e-16 59.5 0.1 6.3e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EFW99768.1 - 0.0018 18.4 0.1 0.0088 16.1 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EFW99768.1 - 0.045 13.7 0.1 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 EFW99768.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain KAP_NTPase PF07693.9 EFW99768.1 - 0.38 9.7 5.2 0.72 8.7 0.5 2.9 3 1 1 4 4 4 0 KAP family P-loop domain Pkinase PF00069.20 EFW99769.1 - 1.9e-43 148.5 0.0 3.2e-43 147.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.7 EFW99769.1 - 4.3e-40 136.5 0.0 7.4e-40 135.7 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.12 EFW99769.1 - 1.1e-22 80.3 0.0 9.7e-22 77.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.1 EFW99769.1 - 0.00031 20.2 0.0 0.0009 18.7 0.0 1.7 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.16 EFW99769.1 - 0.0011 18.3 0.1 1.9 8.1 0.0 2.8 2 0 0 2 2 2 2 PQQ enzyme repeat Kdo PF06293.9 EFW99769.1 - 0.0029 16.7 0.0 0.0056 15.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFW99769.1 - 0.0055 16.4 4.7 0.008 15.9 0.0 3.0 3 0 0 3 3 3 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EFW99769.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.6 EFW99769.1 - 0.76 8.5 0.0 1.2 7.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EXS PF03124.9 EFW99770.1 - 1.6e-88 297.0 0.0 4.3e-88 295.6 0.0 1.6 1 1 0 1 1 1 1 EXS family PAS_9 PF13426.1 EFW99773.1 - 3.9e-30 104.2 0.0 3.7e-16 59.3 0.0 3.4 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.6 EFW99773.1 - 6.3e-17 61.4 0.0 9.1e-11 41.7 0.0 3.5 3 0 0 3 3 3 3 PAS fold GATA PF00320.22 EFW99773.1 - 3.5e-15 55.0 7.4 7.2e-15 54.0 5.1 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS PF00989.19 EFW99773.1 - 7.1e-14 51.5 0.0 4.7e-05 23.1 0.0 3.6 3 1 0 3 3 3 3 PAS fold PAS_11 PF14598.1 EFW99773.1 - 3.9e-11 42.8 0.0 0.00034 20.5 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.5 EFW99773.1 - 5.2e-10 39.3 0.0 0.0069 16.4 0.0 3.9 4 0 0 4 4 4 2 PAS fold PAS_2 PF08446.6 EFW99773.1 - 0.00042 20.7 0.0 0.011 16.1 0.0 2.9 3 0 0 3 3 3 1 PAS fold Atg14 PF10186.4 EFW99773.1 - 1.2 8.0 4.3 0.15 10.9 0.1 1.5 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Complex1_LYR PF05347.10 EFW99774.1 - 5.5e-17 61.3 3.7 7.2e-17 60.9 2.6 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFW99774.1 - 3.6e-14 52.6 3.5 4.4e-14 52.4 2.4 1.1 1 0 0 1 1 1 1 Complex1_LYR-like dDENN PF03455.14 EFW99774.1 - 0.088 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 dDENN domain Complex1_LYR_2 PF13233.1 EFW99774.1 - 0.13 12.7 0.4 0.17 12.4 0.3 1.2 1 0 0 1 1 1 0 Complex1_LYR-like MutS_V PF00488.16 EFW99775.1 - 0.00017 21.1 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 MutS domain V PGBA_C PF15437.1 EFW99775.1 - 3.2 7.9 6.4 0.6 10.2 1.7 1.8 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal Ribosomal_L5_C PF00673.16 EFW99776.1 - 2.2e-23 81.7 0.0 3.2e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus CaATP_NAI PF12515.3 EFW99776.1 - 0.029 13.8 0.0 0.055 12.9 0.0 1.5 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Ribosomal_L5 PF00281.14 EFW99776.1 - 0.12 12.2 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L5 DUF2205 PF10224.4 EFW99777.1 - 8.1e-30 102.2 0.9 1.4e-29 101.4 0.6 1.4 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) DUF3166 PF11365.3 EFW99777.1 - 0.084 13.3 0.2 0.17 12.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3166) EURL PF06937.6 EFW99777.1 - 0.13 11.6 2.6 0.16 11.3 1.8 1.1 1 0 0 1 1 1 0 EURL protein BPL_LplA_LipB PF03099.14 EFW99778.1 - 1.2e-09 38.2 0.0 2.3e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family polyprenyl_synt PF00348.12 EFW99779.1 - 8.6e-30 103.4 0.0 1.1e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase XFP_C PF09363.5 EFW99779.1 - 1.4e-07 31.1 0.0 2.3e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 XFP C-terminal domain WD40 PF00400.27 EFW99780.1 - 6.8e-70 228.6 20.2 2.3e-09 36.7 0.1 11.7 12 0 0 12 12 12 9 WD domain, G-beta repeat Utp12 PF04003.7 EFW99780.1 - 3.8e-19 68.6 0.4 6.5e-19 67.8 0.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 EFW99780.1 - 7.8e-05 20.9 10.1 0.2 9.7 0.1 6.2 5 2 1 6 6 6 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFW99780.1 - 0.00019 20.3 0.4 2.7 6.6 0.0 4.8 3 2 0 5 5 5 1 Nup133 N terminal like eIF2A PF08662.6 EFW99780.1 - 0.046 13.4 0.0 1.8 8.2 0.0 3.4 3 1 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 EFW99780.1 - 0.054 13.2 1.9 63 3.3 0.0 5.0 6 0 0 6 6 6 0 Ciliary BBSome complex subunit 2, middle region CDtoxinA PF03498.9 EFW99780.1 - 0.056 12.8 0.0 4.6 6.6 0.0 2.5 2 0 0 2 2 2 0 Cytolethal distending toxin A/C family Lgl_C PF08596.5 EFW99780.1 - 0.18 10.2 0.0 0.38 9.1 0.0 1.5 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal Band_7 PF01145.20 EFW99780.1 - 0.32 10.8 2.8 3 7.7 0.1 2.3 2 0 0 2 2 2 0 SPFH domain / Band 7 family Evr1_Alr PF04777.8 EFW99781.1 - 1.3e-24 85.8 0.1 1.9e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Erv1 / Alr family COG4 PF08318.7 EFW99782.1 - 1.2e-82 277.3 0.0 2e-81 273.3 0.0 2.0 1 1 0 1 1 1 1 COG4 transport protein TMF_TATA_bd PF12325.3 EFW99782.1 - 0.033 13.9 1.5 2.1 8.0 0.1 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding CorA PF01544.13 EFW99783.1 - 1.5e-26 93.1 4.3 1e-22 80.5 1.4 2.3 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Ricin_B_lectin PF00652.17 EFW99783.1 - 1.3e-14 54.3 0.0 1e-06 28.7 0.0 3.9 2 2 1 3 3 3 3 Ricin-type beta-trefoil lectin domain Clavanin PF05452.6 EFW99783.1 - 0.17 11.8 0.1 16 5.5 0.1 2.7 2 0 0 2 2 2 0 Clavanin RAP1 PF07218.6 EFW99784.1 - 2.2 6.2 7.1 3.1 5.7 4.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pkinase PF00069.20 EFW99785.1 - 2.2e-69 233.4 0.0 9.7e-69 231.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99785.1 - 5.6e-50 169.8 0.0 2.6e-49 167.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99785.1 - 6.9e-05 21.9 0.0 0.0055 15.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Rax2 PF12768.2 EFW99786.1 - 7.7e-80 268.0 17.2 3.7e-75 252.7 0.1 5.1 4 1 0 5 5 5 5 Cortical protein marker for cell polarity Kelch_6 PF13964.1 EFW99786.1 - 0.81 9.9 8.2 1.8 8.9 0.1 5.0 5 0 0 5 5 5 0 Kelch motif Cys_Met_Meta_PP PF01053.15 EFW99788.1 - 4.6e-57 193.0 0.0 9.2e-57 192.0 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF2017 PF09438.5 EFW99788.1 - 0.029 13.9 0.2 0.071 12.6 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2017) Aminotran_1_2 PF00155.16 EFW99788.1 - 0.074 11.9 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Cyclin PF08613.6 EFW99789.1 - 1.9e-12 47.8 0.0 3.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EFW99789.1 - 0.0007 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain AIG2_2 PF13772.1 EFW99790.1 - 4.2e-06 26.7 0.0 1.9e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 AIG2-like family Ribosomal_S19e PF01090.14 EFW99791.1 - 1.4e-57 193.0 0.6 1.6e-57 192.8 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_45 PF14947.1 EFW99791.1 - 0.078 12.7 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix NMO PF03060.10 EFW99792.1 - 6.3e-74 249.0 4.4 7.8e-74 248.7 3.1 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFW99792.1 - 2.2e-07 30.0 0.1 1.8e-05 23.7 0.0 2.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EFW99792.1 - 0.16 10.7 10.7 0.028 13.2 4.9 1.5 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Sod_Fe_N PF00081.17 EFW99793.1 - 3.8e-16 59.0 3.0 5.5e-16 58.6 2.0 1.2 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.13 EFW99793.1 - 1.2e-08 34.7 0.0 2.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain ApbA_C PF08546.6 EFW99794.1 - 3.3e-23 82.0 0.0 5e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFW99794.1 - 3.1e-12 46.1 0.0 1e-11 44.5 0.0 1.8 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA UQ_con PF00179.21 EFW99795.1 - 7.6e-21 74.0 0.0 1.1e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFW99795.1 - 0.051 13.3 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 EFW99795.1 - 0.051 13.4 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain Fungal_trans PF04082.13 EFW99796.1 - 3.7e-08 32.5 1.7 4.9e-08 32.1 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain PgpA PF04608.8 EFW99797.1 - 0.094 12.5 1.9 0.14 11.9 0.6 1.8 2 0 0 2 2 2 0 Phosphatidylglycerophosphatase A Vif PF00559.12 EFW99797.1 - 0.17 11.7 0.2 0.17 11.7 0.1 1.5 2 0 0 2 2 2 0 Retroviral Vif (Viral infectivity) protein Lactamase_B PF00753.22 EFW99799.1 - 7.2e-23 81.2 3.6 7.6e-22 77.9 2.5 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFW99799.1 - 2.6e-05 23.8 0.1 3.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain GFA PF04828.9 EFW99800.1 - 1.8e-09 37.3 0.0 2.1e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DUF2197 PF09963.4 EFW99800.1 - 0.082 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) UCR_6-4kD PF08997.5 EFW99801.1 - 1.5 8.5 6.0 0.22 11.2 0.2 2.7 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein LDB19 PF13002.2 EFW99802.1 - 2e-33 115.4 0.1 3.3e-33 114.7 0.1 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.24 EFW99802.1 - 7.7e-06 25.7 0.1 2e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Pkinase PF00069.20 EFW99803.1 - 4.2e-12 45.7 0.0 5.9e-05 22.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99803.1 - 4.4e-05 22.6 0.0 0.13 11.2 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase zf-C2H2_jaz PF12171.3 EFW99804.1 - 2.3e-05 24.4 2.9 2.4e-05 24.3 0.7 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFW99804.1 - 0.14 12.3 0.3 0.23 11.5 0.2 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 EFW99804.1 - 0.33 11.2 3.7 4.6 7.5 0.8 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF2884 PF11101.3 EFW99805.1 - 0.036 13.4 0.9 0.68 9.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) DUF2422 PF10337.4 EFW99806.1 - 4.7e-83 279.5 8.1 4.7e-83 279.5 5.6 3.6 3 2 1 4 4 4 1 Protein of unknown function (DUF2422) FUSC_2 PF13515.1 EFW99806.1 - 8.4e-18 64.5 15.2 8.4e-18 64.5 10.5 3.3 2 1 0 2 2 2 1 Fusaric acid resistance protein-like DUF2421 PF10334.4 EFW99806.1 - 2.6e-07 30.4 0.1 1.4e-06 28.1 0.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2421) RF-1 PF00472.15 EFW99807.1 - 9.4e-26 89.8 2.0 1.2e-25 89.5 1.4 1.1 1 0 0 1 1 1 1 RF-1 domain DUF4502 PF14950.1 EFW99807.1 - 0.21 10.7 3.0 0.26 10.4 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) M20_dimer PF07687.9 EFW99808.1 - 1e-19 70.2 0.0 2.4e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 EFW99808.1 - 2.3e-19 69.6 0.5 3.3e-19 69.1 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.12 EFW99808.1 - 0.14 11.8 0.7 0.26 10.9 0.1 1.8 2 0 0 2 2 2 0 Peptidase family M28 SWIB PF02201.13 EFW99809.1 - 1.7e-22 78.9 1.6 1.4e-21 75.9 0.2 2.3 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.6 EFW99809.1 - 7.5e-15 54.4 1.0 1.9e-14 53.1 0.7 1.7 1 0 0 1 1 1 1 DEK C terminal domain CENP-U PF13097.1 EFW99809.1 - 0.57 10.0 7.6 1.3 8.9 2.9 2.6 2 1 1 3 3 3 0 CENP-A nucleosome associated complex (NAC) subunit RabGAP-TBC PF00566.13 EFW99810.1 - 1.1e-23 83.8 0.0 1.9e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ADH_N PF08240.7 EFW99811.1 - 6.7e-15 54.7 8.8 1.6e-14 53.5 6.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFW99811.1 - 7.5e-13 48.1 0.0 1.2e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFW99811.1 - 0.0006 19.0 0.0 0.00094 18.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 EFW99811.1 - 0.0037 16.7 0.0 0.0071 15.8 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.10 EFW99811.1 - 0.0049 16.7 0.0 0.013 15.2 0.0 1.7 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 EFW99811.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Aa_trans PF01490.13 EFW99812.1 - 2.2e-32 112.0 31.7 4.5e-32 111.0 22.0 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Methyltransf_11 PF08241.7 EFW99813.1 - 2.7e-16 59.8 0.1 4.3e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW99813.1 - 3.3e-15 55.9 0.0 4.6e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFW99813.1 - 3.3e-15 56.1 0.0 4.9e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99813.1 - 5.2e-10 39.8 0.0 1.1e-09 38.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99813.1 - 2.3e-09 37.6 0.0 3.8e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFW99813.1 - 1.4e-08 34.8 0.1 2.8e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW99813.1 - 1.6e-08 34.8 0.1 2.6e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFW99813.1 - 1.2e-07 31.2 0.1 2.3e-07 30.3 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 EFW99813.1 - 3.5e-07 29.5 0.0 4.9e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.14 EFW99813.1 - 3.4e-06 26.7 0.0 6.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 EFW99813.1 - 1.1e-05 24.6 0.0 1.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 EFW99813.1 - 1.3e-05 24.0 0.0 2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.13 EFW99813.1 - 3.2e-05 23.1 0.0 4.5e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.6 EFW99813.1 - 0.00059 19.2 0.0 0.00079 18.8 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.1 EFW99813.1 - 0.0012 18.5 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 EFW99813.1 - 0.011 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW UPF0020 PF01170.13 EFW99813.1 - 0.053 13.1 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 TPMT PF05724.6 EFW99813.1 - 0.053 12.9 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) FmrO PF07091.6 EFW99813.1 - 0.076 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_15 PF09445.5 EFW99813.1 - 0.093 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PrmA PF06325.8 EFW99813.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Peptidase_M16_C PF05193.16 EFW99814.1 - 1.3e-17 64.1 0.0 2.3e-13 50.2 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFW99814.1 - 9.7e-05 22.1 0.0 0.0004 20.1 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) CobT PF06213.7 EFW99814.1 - 0.019 14.1 15.9 0.032 13.3 11.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.9 EFW99814.1 - 0.67 7.9 18.6 0.98 7.3 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Polysacc_deac_1 PF01522.16 EFW99815.1 - 3.8e-24 84.6 0.0 5.6e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DNA_pol_B_thumb PF14791.1 EFW99815.1 - 0.6 9.8 2.3 34 4.2 0.0 3.0 3 0 0 3 3 3 0 DNA polymerase beta thumb Microtub_assoc PF07989.6 EFW99816.1 - 6.2e-27 93.2 3.8 6.2e-27 93.2 2.7 13.0 8 3 4 14 14 14 1 Microtubule associated PACT_coil_coil PF10495.4 EFW99816.1 - 9.2e-06 25.5 0.5 8.2e-05 22.4 0.3 2.8 1 1 0 1 1 1 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein AAA_13 PF13166.1 EFW99816.1 - 0.0001 20.9 121.2 0.0019 16.7 14.6 5.5 1 1 3 5 5 5 4 AAA domain DUF4200 PF13863.1 EFW99816.1 - 0.0011 18.8 11.2 0.0011 18.8 7.8 12.3 5 3 6 11 11 11 2 Domain of unknown function (DUF4200) Reo_sigmaC PF04582.7 EFW99816.1 - 0.0018 17.5 62.8 0.067 12.3 2.6 8.3 1 1 4 8 8 8 5 Reovirus sigma C capsid protein ERM PF00769.14 EFW99816.1 - 0.0021 17.6 44.4 0.0021 17.6 30.8 8.4 2 1 6 9 9 9 3 Ezrin/radixin/moesin family CCDC155 PF14662.1 EFW99816.1 - 0.0033 17.0 7.7 0.0033 17.0 5.4 9.6 2 1 6 9 9 9 3 Coiled-coil region of CCDC155 HALZ PF02183.13 EFW99816.1 - 0.012 15.2 0.7 0.012 15.2 0.5 13.5 14 1 1 15 15 15 0 Homeobox associated leucine zipper Spc7 PF08317.6 EFW99816.1 - 0.016 13.8 153.0 0.0084 14.8 9.8 9.2 2 2 7 10 10 10 0 Spc7 kinetochore protein Filament PF00038.16 EFW99816.1 - 0.65 9.4 185.3 0.94 8.8 15.0 9.8 1 1 7 8 8 8 0 Intermediate filament protein AAA PF00004.24 EFW99817.1 - 2.2e-07 31.1 0.2 1.1e-06 28.8 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 EFW99817.1 - 3.9e-05 22.5 0.0 0.054 12.1 0.0 3.0 3 0 0 3 3 3 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 EFW99817.1 - 0.002 18.2 0.1 0.0077 16.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFW99817.1 - 0.0032 18.2 0.1 0.023 15.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 EFW99817.1 - 0.0064 16.5 0.2 0.021 14.7 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 EFW99817.1 - 0.014 15.1 0.3 0.33 10.7 0.0 3.1 2 0 0 2 2 2 0 Part of AAA domain AAA_5 PF07728.9 EFW99817.1 - 0.068 12.8 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EFW99817.1 - 0.095 13.0 0.0 0.32 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFW99817.1 - 0.23 11.3 0.0 0.97 9.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain M16C_assoc PF08367.6 EFW99818.1 - 3.5e-51 173.4 0.0 4.8e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 EFW99818.1 - 9.6e-30 103.6 0.0 1.4e-16 60.6 0.0 2.5 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFW99818.1 - 5.8e-08 32.6 0.0 7.9e-06 25.7 0.0 3.1 2 1 1 3 3 3 1 Insulinase (Peptidase family M16) 7tm_2 PF00002.19 EFW99819.1 - 1.4e-12 47.1 9.2 2.6e-12 46.3 6.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 EFW99819.1 - 1.8e-11 43.4 9.1 1.8e-11 43.4 6.3 1.6 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.16 EFW99819.1 - 3.3e-08 33.0 1.5 4.8e-08 32.4 1.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.3 EFW99819.1 - 5.7e-07 29.3 11.2 9.4e-07 28.5 7.7 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 TMEM190 PF15431.1 EFW99819.1 - 0.012 15.5 0.1 0.04 13.8 0.1 1.8 2 0 0 2 2 2 0 Transmembrane protein 190 FixP_N PF14715.1 EFW99819.1 - 0.097 12.0 2.7 0.43 9.9 1.9 2.1 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP NVEALA PF14055.1 EFW99819.1 - 0.18 11.5 0.1 0.63 9.7 0.0 1.9 1 0 0 1 1 1 0 NVEALA protein Carb_bind PF10645.4 EFW99820.1 - 2.3e-21 75.3 2.9 6.9e-21 73.8 2.0 1.9 1 0 0 1 1 1 1 Carbohydrate binding Zn_clus PF00172.13 EFW99820.1 - 3.2e-09 36.5 11.4 8.2e-09 35.2 7.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRS1 PF04939.7 EFW99821.1 - 1e-52 177.9 1.7 1.2e-52 177.7 1.2 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DUF2849 PF11011.3 EFW99821.1 - 0.33 11.2 3.5 0.26 11.5 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2849) Ribosomal_L5_C PF00673.16 EFW99822.1 - 6.9e-22 77.0 0.0 9.6e-22 76.5 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 EFW99822.1 - 2.9e-21 74.9 0.0 6.9e-21 73.7 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L5 PCI PF01399.22 EFW99823.1 - 3.8e-09 36.7 0.0 8e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain Pyr_redox_3 PF13738.1 EFW99824.1 - 2e-22 80.2 0.2 4.4e-22 79.1 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFW99824.1 - 3.4e-12 46.2 1.5 9.2e-11 41.6 0.0 3.4 3 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFW99824.1 - 7.5e-07 28.3 0.3 1.7e-05 23.8 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.14 EFW99824.1 - 1.6e-06 26.6 0.1 1.5e-05 23.4 0.0 2.1 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFW99824.1 - 1.1e-05 25.3 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFW99824.1 - 1.8e-05 24.5 0.3 0.0021 17.8 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.19 EFW99824.1 - 2.5e-05 23.3 3.6 3.3e-05 22.9 0.1 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase Mqo PF06039.10 EFW99824.1 - 0.00065 17.9 0.0 0.00099 17.4 0.0 1.2 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) Shikimate_DH PF01488.15 EFW99824.1 - 0.04 14.0 0.2 6.6 6.8 0.0 3.0 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 EFW99824.1 - 0.22 11.2 1.9 2.3 7.9 0.3 2.3 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus adh_short PF00106.20 EFW99825.1 - 1.2e-07 31.8 1.7 3.7e-07 30.2 1.2 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW99825.1 - 0.00011 22.0 0.3 0.00015 21.6 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EFW99825.1 - 0.085 12.2 0.6 0.48 9.8 0.4 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sec8_exocyst PF04048.9 EFW99826.1 - 4.1e-46 156.1 0.2 7.8e-46 155.2 0.2 1.5 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 EFW99826.1 - 4.4e-10 38.9 0.9 8.6e-10 37.9 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) NAAA-beta PF15508.1 EFW99826.1 - 0.12 12.7 0.1 23 5.3 0.0 3.6 2 1 1 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase MFS_1 PF07690.11 EFW99827.1 - 8.9e-37 126.5 35.2 8.9e-37 126.5 24.4 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFW99827.1 - 8e-16 57.6 6.1 2e-15 56.3 0.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter Arrestin_C PF02752.17 EFW99828.1 - 1.4e-15 57.6 0.0 4.3e-15 56.0 0.0 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EFW99828.1 - 9.5e-11 41.7 0.2 0.0002 21.2 0.0 2.4 1 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain zf-H2C2_2 PF13465.1 EFW99829.1 - 6.5e-20 70.3 20.2 5.2e-09 35.9 1.2 4.5 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 EFW99829.1 - 1.4e-13 50.2 23.3 3.3e-05 23.9 0.5 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFW99829.1 - 1e-10 41.1 20.3 0.0035 17.5 0.2 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-ISL3 PF14690.1 EFW99829.1 - 0.024 14.6 3.6 0.07 13.1 2.5 1.9 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C2H2_jaz PF12171.3 EFW99829.1 - 0.095 12.8 2.7 0.44 10.7 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 EFW99829.1 - 1 9.3 4.2 7.1 6.6 0.1 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-met PF12874.2 EFW99829.1 - 1.1 9.5 9.9 5.9 7.2 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DUF3722 PF12519.3 EFW99830.1 - 3.4e-77 259.1 0.0 6.9e-77 258.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3722) Porin_3 PF01459.17 EFW99830.1 - 2.3e-06 27.1 0.1 0.0054 16.0 0.1 2.4 2 0 0 2 2 2 2 Eukaryotic porin Med3 PF11593.3 EFW99830.1 - 9.9 5.2 14.8 1.8 7.7 6.3 2.3 2 1 1 3 3 3 0 Mediator complex subunit 3 fungal DUF4207 PF13904.1 EFW99831.1 - 0.44 9.8 2.3 0.69 9.2 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) Ammonium_transp PF00909.16 EFW99832.1 - 6.5e-111 370.6 21.5 7.8e-111 370.3 14.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family HEAT PF02985.17 EFW99833.1 - 7.2e-21 72.3 10.5 0.0028 17.5 0.0 9.8 9 0 0 9 9 8 5 HEAT repeat HEAT_2 PF13646.1 EFW99833.1 - 1.6e-18 66.7 17.4 2.1e-08 34.3 0.4 8.2 3 3 5 8 8 8 7 HEAT repeats HEAT_EZ PF13513.1 EFW99833.1 - 2e-17 63.1 18.8 7.8e-09 35.7 0.2 9.4 8 1 2 10 10 8 3 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFW99833.1 - 4.5e-12 46.1 0.0 0.007 16.7 0.1 6.9 5 2 2 7 7 7 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 EFW99833.1 - 2.1e-08 33.3 5.7 7.4e-06 24.9 0.1 4.3 4 1 1 5 5 5 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.3 EFW99833.1 - 1.7e-07 30.8 0.7 0.0015 17.8 0.1 5.4 5 1 1 6 6 6 2 CLASP N terminal RIX1 PF08167.7 EFW99833.1 - 1.7e-07 31.0 0.2 0.031 13.9 0.0 5.4 4 1 1 5 5 5 2 rRNA processing/ribosome biogenesis Adaptin_N PF01602.15 EFW99833.1 - 7.8e-06 24.4 1.7 0.0011 17.4 0.3 3.9 4 1 0 4 4 4 1 Adaptin N terminal region Cnd1 PF12717.2 EFW99833.1 - 5.2e-05 23.1 0.3 2.3 8.0 0.1 4.4 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Proteasom_PSMB PF10508.4 EFW99833.1 - 0.00037 18.9 0.2 0.0017 16.7 0.0 2.2 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit V-ATPase_H_N PF03224.9 EFW99833.1 - 0.00072 18.7 4.8 0.15 11.1 0.1 2.8 3 0 0 3 3 3 2 V-ATPase subunit H DUF3554 PF12074.3 EFW99833.1 - 0.0068 15.8 0.0 4.7 6.5 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF3554) DUF3535 PF12054.3 EFW99833.1 - 0.013 14.1 1.9 0.17 10.4 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3535) IBN_N PF03810.14 EFW99833.1 - 0.069 13.0 1.2 0.33 10.9 0.1 2.9 2 1 0 2 2 2 0 Importin-beta N-terminal domain Ipi1_N PF12333.3 EFW99833.1 - 0.092 12.7 0.3 1.4 8.9 0.0 3.2 2 1 1 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation DUF3385 PF11865.3 EFW99833.1 - 0.15 11.9 1.8 78 3.1 0.0 4.7 4 1 0 4 4 4 0 Domain of unknown function (DUF3385) Arm PF00514.18 EFW99833.1 - 0.56 10.1 9.8 5.5 6.9 0.0 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat UNC45-central PF11701.3 EFW99833.1 - 0.84 9.2 3.7 36 3.9 0.1 4.1 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central MFS_1 PF07690.11 EFW99834.1 - 1.8e-26 92.6 22.7 1.8e-26 92.6 15.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily RskA PF10099.4 EFW99834.1 - 0.076 12.7 2.0 5.6 6.6 0.1 2.9 3 0 0 3 3 3 0 Anti-sigma-K factor rskA DUF3237 PF11578.3 EFW99835.1 - 1e-31 109.2 0.0 1.1e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Peptidase_C48 PF02902.14 EFW99836.1 - 2.1e-14 53.6 0.0 1.8e-13 50.6 0.0 2.2 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SNase PF00565.12 EFW99837.1 - 7.3e-21 74.4 0.0 1.4e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Transglut_core PF01841.14 EFW99838.1 - 1.4e-12 47.8 0.3 3.7e-12 46.4 0.2 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.12 EFW99838.1 - 4.6e-06 26.0 0.0 1.4e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFW99838.1 - 3e-05 23.2 0.0 3e-05 23.2 0.0 2.4 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.1 EFW99838.1 - 0.00066 19.2 0.4 0.0018 17.8 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Ank_2 PF12796.2 EFW99839.1 - 1.4e-35 121.5 0.0 2.7e-14 53.2 0.0 4.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99839.1 - 1.5e-31 106.6 0.0 5.7e-05 22.7 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.1 EFW99839.1 - 8.2e-27 93.0 0.3 3.6e-09 36.8 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99839.1 - 1.5e-25 86.6 0.0 0.00074 19.5 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 EFW99839.1 - 2e-20 72.3 0.2 4.5e-07 29.9 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) NACHT PF05729.7 EFW99839.1 - 1.5e-08 34.4 0.0 3.8e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EFW99839.1 - 3.4e-05 23.9 0.0 0.00016 21.7 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFW99839.1 - 0.0003 20.9 0.2 0.0028 17.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain KAP_NTPase PF07693.9 EFW99839.1 - 0.018 14.0 2.0 0.89 8.4 0.1 3.1 2 2 1 3 3 3 0 KAP family P-loop domain RNA_helicase PF00910.17 EFW99839.1 - 0.094 12.8 0.0 0.71 10.0 0.0 2.4 2 1 0 2 2 2 0 RNA helicase TBCA PF02970.11 EFW99840.1 - 2e-17 62.9 4.3 2.9e-17 62.5 3.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor A Mac PF12464.3 EFW99840.1 - 0.12 12.3 1.2 0.49 10.4 0.2 2.1 2 0 0 2 2 2 0 Maltose acetyltransferase CENP-Q PF13094.1 EFW99840.1 - 1.1 9.2 5.4 2.9 7.8 3.7 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Pyr_redox_3 PF13738.1 EFW99841.1 - 3.7e-13 49.9 0.1 7.7e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFW99841.1 - 6.3e-10 39.0 2.0 2.8e-09 36.9 0.6 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFW99841.1 - 3.8e-09 36.7 0.0 4.1e-06 26.8 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFW99841.1 - 6.7e-09 34.4 0.0 1.3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFW99841.1 - 1.1e-08 35.0 0.3 4.6e-08 32.9 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFW99841.1 - 1.3e-06 27.7 0.0 0.0075 15.3 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 EFW99841.1 - 0.00019 21.7 0.3 0.72 10.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFW99841.1 - 0.0013 17.9 0.0 0.0023 17.0 0.0 1.4 1 0 0 1 1 1 1 Thi4 family K_oxygenase PF13434.1 EFW99841.1 - 0.0029 16.5 0.0 0.64 8.8 0.0 3.3 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 EFW99841.1 - 0.017 14.1 0.0 0.038 13.0 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.9 EFW99841.1 - 0.028 12.9 0.0 0.049 12.0 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Peptidase_C12 PF01088.16 EFW99842.1 - 1.3e-45 155.1 0.0 5.4e-44 149.9 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Med3 PF11593.3 EFW99842.1 - 0.095 11.9 0.7 0.14 11.3 0.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Aconitase PF00330.15 EFW99843.1 - 5e-176 585.7 0.0 8.2e-176 585.0 0.0 1.3 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFW99843.1 - 1.2e-42 145.0 0.0 2.2e-42 144.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Transglut_core2 PF13369.1 EFW99844.1 - 8.2e-15 54.5 0.0 3e-14 52.7 0.0 1.9 1 1 0 1 1 1 1 Transglutaminase-like superfamily YccV-like PF08755.6 EFW99844.1 - 1.7e-06 27.8 0.0 5.3e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like F-box-like PF12937.2 EFW99844.1 - 0.0011 18.6 0.3 0.0027 17.3 0.2 1.8 1 0 0 1 1 1 1 F-box-like THOC7 PF05615.8 EFW99845.1 - 1.9e-31 109.1 0.1 1.9e-31 109.1 0.1 1.6 2 0 0 2 2 2 1 Tho complex subunit 7 Sigma70_ner PF04546.8 EFW99845.1 - 0.018 14.6 0.3 0.018 14.6 0.2 3.1 3 0 0 3 3 3 0 Sigma-70, non-essential region zf-C4H2 PF10146.4 EFW99845.1 - 0.035 14.1 0.3 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 Zinc finger-containing protein TMEM247 PF15444.1 EFW99845.1 - 0.069 12.9 1.9 0.085 12.6 0.0 2.1 3 0 0 3 3 3 0 Transmembrane protein 247 LSM PF01423.17 EFW99846.1 - 4.5e-19 67.7 0.1 5.6e-19 67.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain RRM_1 PF00076.17 EFW99847.1 - 4.9e-31 106.1 0.0 2.4e-15 55.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99847.1 - 1.7e-15 56.5 0.0 6.6e-09 35.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99847.1 - 4.6e-14 52.1 0.0 2.2e-06 27.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EFW99847.1 - 0.0042 16.8 0.0 1.8 8.3 0.0 2.4 1 1 1 2 2 2 2 Limkain b1 OB_RNB PF08206.6 EFW99847.1 - 0.01 15.3 0.6 3.9 7.0 0.1 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain UPF0220 PF05255.6 EFW99848.1 - 7.3e-60 200.9 1.4 8.1e-60 200.8 1.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) F-box-like PF12937.2 EFW99849.1 - 0.0032 17.1 0.1 0.0079 15.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like CPSF100_C PF13299.1 EFW99849.1 - 0.88 9.7 7.1 3.8 7.6 5.0 2.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Suf PF05843.9 EFW99849.1 - 7.1 6.2 16.0 1.5 8.4 7.3 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) p450 PF00067.17 EFW99851.1 - 2.4e-55 187.8 0.0 2.9e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Proteasome PF00227.21 EFW99852.1 - 1.3e-48 164.8 0.1 1.4e-48 164.6 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Fungal_trans PF04082.13 EFW99853.1 - 0.00036 19.4 0.4 0.002 17.0 0.1 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain LTV PF04180.9 EFW99854.1 - 1.9e-108 363.6 16.9 2.2e-108 363.4 11.7 1.0 1 0 0 1 1 1 1 Low temperature viability protein DNA_pol_phi PF04931.8 EFW99855.1 - 6e-41 140.0 35.0 2.8e-19 68.4 3.8 4.3 3 1 1 4 4 4 4 DNA polymerase phi HEAT PF02985.17 EFW99855.1 - 0.1 12.7 1.2 1.4 9.2 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat Ank_2 PF12796.2 EFW99856.1 - 4.4e-65 216.0 19.9 1.4e-16 60.5 0.1 5.2 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFW99856.1 - 1.6e-42 143.1 16.2 2.8e-12 46.7 0.1 6.9 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.25 EFW99856.1 - 1.1e-36 122.8 27.4 9.2e-08 31.5 0.1 10.1 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.1 EFW99856.1 - 2.4e-30 101.5 12.5 0.0013 18.7 0.0 10.0 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.1 EFW99856.1 - 3.9e-24 84.1 25.4 1.3e-07 31.5 0.3 8.2 5 2 4 9 9 9 6 Ankyrin repeats (many copies) GTP_EFTU PF00009.22 EFW99856.1 - 7.8e-20 71.1 0.0 1.5e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFW99856.1 - 3.1e-12 46.5 0.0 6.2e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFW99856.1 - 2.1e-08 34.1 0.7 4.6e-08 33.0 0.5 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 CorA PF01544.13 EFW99856.1 - 3e-07 29.7 1.4 1e-06 28.0 1.0 1.9 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein GTP_EFTU_D4 PF14578.1 EFW99856.1 - 0.011 15.3 0.2 0.025 14.2 0.1 1.6 1 0 0 1 1 1 0 Elongation factor Tu domain 4 Miro PF08477.8 EFW99856.1 - 0.15 12.5 0.0 0.59 10.6 0.0 2.1 1 1 0 1 1 1 0 Miro-like protein UBA_4 PF14555.1 EFW99857.1 - 5.4e-13 48.2 0.2 1.2e-12 47.1 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.1 EFW99857.1 - 4.8e-12 45.7 0.1 2.4e-11 43.4 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like UBX PF00789.15 EFW99857.1 - 9.4e-08 32.0 0.0 1.9e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 UBX domain Thioredox_DsbH PF03190.10 EFW99857.1 - 0.059 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Serglycin PF04360.7 EFW99857.1 - 0.11 12.2 1.3 0.31 10.7 0.3 2.0 2 0 0 2 2 2 0 Serglycin Ribosomal_S11 PF00411.14 EFW99859.1 - 1.1e-40 138.2 0.4 1.3e-40 137.9 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF2252 PF10009.4 EFW99859.1 - 0.074 11.9 0.0 0.089 11.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Pkinase PF00069.20 EFW99860.1 - 5.1e-66 222.4 0.0 7.7e-66 221.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99860.1 - 5.3e-46 156.7 0.0 9.9e-46 155.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFW99860.1 - 1.8e-06 27.1 0.0 5.8e-05 22.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.20 EFW99861.1 - 1.1e-66 224.6 0.0 1.8e-66 223.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99861.1 - 6.5e-41 140.1 0.0 9.9e-41 139.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NAD_binding_6 PF08030.7 EFW99861.1 - 8.6e-18 64.7 0.0 1.6e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EFW99861.1 - 1.2e-17 64.1 13.2 2.2e-17 63.3 8.3 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component Kinase-like PF14531.1 EFW99861.1 - 1.4e-09 37.3 0.0 1.6e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like FAD_binding_8 PF08022.7 EFW99861.1 - 2.3e-09 37.0 0.0 6.2e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain Kdo PF06293.9 EFW99861.1 - 0.0022 17.0 0.0 0.0051 15.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFW99861.1 - 0.037 13.7 1.2 0.14 11.8 0.1 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family NAD_binding_1 PF00175.16 EFW99861.1 - 0.055 14.0 0.0 1 9.9 0.0 2.6 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Seadorna_VP7 PF07387.6 EFW99861.1 - 0.53 9.0 0.0 0.83 8.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Lactamase_B PF00753.22 EFW99862.1 - 4.4e-23 81.9 3.6 4.4e-23 81.9 2.5 1.5 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFW99862.1 - 1.1e-06 28.3 0.1 1.3e-06 28.1 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EFW99862.1 - 0.017 14.8 0.1 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DUF3430 PF11912.3 EFW99863.1 - 0.00053 19.8 4.5 0.00062 19.6 3.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3430) TauD PF02668.11 EFW99864.1 - 3.2e-55 187.5 0.6 3.9e-55 187.3 0.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Nucleoplasmin PF03066.10 EFW99865.1 - 0.97 8.9 5.6 1.4 8.4 3.9 1.3 1 0 0 1 1 1 0 Nucleoplasmin Whi5 PF08528.6 EFW99866.1 - 4.2e-12 45.3 0.2 7.1e-12 44.5 0.2 1.4 1 0 0 1 1 1 1 Whi5 like MutS_V PF00488.16 EFW99868.1 - 2.9e-75 252.7 0.0 1e-74 250.9 0.0 1.9 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFW99868.1 - 4e-37 127.9 1.5 1.3e-36 126.2 1.2 1.8 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.15 EFW99868.1 - 3.6e-27 94.6 0.1 9.4e-27 93.2 0.0 1.8 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.12 EFW99868.1 - 1.6e-09 37.9 0.1 1.8e-08 34.5 0.0 2.6 3 0 0 3 3 3 1 MutS domain II CSTF2_hinge PF14327.1 EFW99869.1 - 1.3e-26 92.4 0.3 2.3e-26 91.6 0.2 1.4 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.17 EFW99869.1 - 7.8e-21 73.4 0.0 1.4e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99869.1 - 7e-14 51.5 0.0 1.4e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) R3H PF01424.17 EFW99869.1 - 1.4e-12 47.0 0.1 3.6e-12 45.7 0.1 1.7 1 0 0 1 1 1 1 R3H domain RRM_5 PF13893.1 EFW99869.1 - 8.3e-06 25.5 0.0 1.5e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 EFW99869.1 - 1.9e-05 23.8 3.0 5e-05 22.5 2.1 1.6 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal zf-NF-X1 PF01422.12 EFW99869.1 - 0.0026 17.6 11.5 0.0026 17.6 8.0 12.5 12 1 0 12 12 12 6 NF-X1 type zinc finger Pox_Ag35 PF03286.9 EFW99869.1 - 4.3 6.8 27.3 11 5.4 18.9 1.7 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1510 PF07423.6 EFW99869.1 - 6.6 6.0 37.8 11 5.2 26.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) AMP-binding PF00501.23 EFW99870.1 - 2.1e-44 151.5 0.0 6.8e-30 103.7 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.1 EFW99870.1 - 0.01 16.7 0.0 0.022 15.7 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Myb_DNA-bind_6 PF13921.1 EFW99871.1 - 2.3e-09 37.2 0.1 3.4e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFW99871.1 - 3.7e-05 23.6 0.0 7.3e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rad21_Rec8_N PF04825.8 EFW99873.1 - 6.5e-40 135.5 0.0 1.1e-39 134.7 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 EFW99873.1 - 1.6e-08 33.5 0.7 5.1e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 EFW99873.1 - 0.079 12.5 0.0 0.88 9.0 0.0 2.1 2 0 0 2 2 2 0 ScpA/B protein Pam17 PF08566.5 EFW99874.1 - 2.1e-59 200.0 0.0 3.3e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Glyco_hydro_76 PF03663.9 EFW99876.1 - 3.7e-148 493.8 31.1 5.1e-148 493.3 21.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Taxilin PF09728.4 EFW99877.1 - 2.3e-63 214.1 64.1 2.3e-63 214.1 44.4 2.6 2 1 0 2 2 2 1 Myosin-like coiled-coil protein DUF2828 PF11443.3 EFW99877.1 - 2.8e-54 184.2 0.0 1.3e-31 109.4 0.0 4.1 2 2 1 3 3 3 2 Domain of unknown function (DUF2828) Alg6_Alg8 PF03155.10 EFW99878.1 - 1.4e-125 419.7 21.8 3.7e-82 276.6 4.1 2.5 3 0 0 3 3 3 2 ALG6, ALG8 glycosyltransferase family SURF4 PF02077.10 EFW99878.1 - 8.8e-92 307.2 5.6 8.8e-92 307.2 3.9 2.0 2 0 0 2 2 2 1 SURF4 family HAD_2 PF13419.1 EFW99879.1 - 9.9e-37 126.8 0.0 1.2e-36 126.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFW99879.1 - 0.0023 18.4 0.0 0.13 12.6 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFW99879.1 - 0.0046 16.6 0.0 0.0084 15.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like STAT2_C PF12188.3 EFW99879.1 - 0.0063 16.2 0.0 0.048 13.4 0.0 2.1 2 0 0 2 2 2 1 Signal transducer and activator of transcription 2 C terminal DUF3235 PF11574.3 EFW99879.1 - 0.13 12.4 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) Glyco_transf_20 PF00982.16 EFW99880.1 - 6.9e-164 545.8 0.0 9.5e-164 545.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EFW99880.1 - 2.3e-42 144.4 0.0 3.7e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.6 EFW99880.1 - 0.0032 17.0 0.5 0.0058 16.1 0.3 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Hydrolase_3 PF08282.7 EFW99880.1 - 0.072 12.6 0.0 0.89 9.0 0.0 2.3 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Pkinase PF00069.20 EFW99881.1 - 0.0001 21.5 0.0 0.00018 20.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFW99881.1 - 0.0037 16.3 0.5 0.021 13.8 0.4 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase MFS_1 PF07690.11 EFW99882.1 - 2.1e-23 82.6 25.4 9.5e-23 80.4 17.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3317 PF11779.3 EFW99883.1 - 5.2e-16 57.8 5.0 7.1e-16 57.3 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3317) NmrA PF05368.8 EFW99885.1 - 3.2e-15 56.0 0.0 3.9e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFW99885.1 - 4e-06 26.9 0.0 5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EFW99885.1 - 0.023 14.3 0.0 0.042 13.5 0.0 1.5 1 1 0 1 1 1 0 KR domain BOP1NT PF08145.7 EFW99886.1 - 7.5e-100 333.9 0.3 1e-99 333.5 0.2 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 EFW99886.1 - 4.3e-31 105.6 5.7 4e-14 51.8 1.0 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat MMR_HSR1 PF01926.18 EFW99887.1 - 1.3e-17 63.8 0.1 2.4e-15 56.5 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 EFW99887.1 - 9e-07 28.3 0.4 1.1e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 EFW99887.1 - 0.00018 20.7 0.0 0.00033 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EFW99887.1 - 0.00043 20.1 0.3 0.032 14.0 0.1 2.6 2 0 0 2 2 2 1 Dynamin family AIG1 PF04548.11 EFW99887.1 - 0.0051 15.9 0.0 0.011 14.8 0.0 1.6 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 EFW99887.1 - 0.01 16.2 0.0 0.031 14.7 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein DUF2956 PF11169.3 EFW99888.1 - 0.098 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Bd3614_N PF14442.1 EFW99888.1 - 0.39 10.6 1.9 0.57 10.1 1.3 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Ecm29 PF13001.2 EFW99889.1 - 3e-102 342.7 0.0 7.1e-102 341.4 0.0 1.7 1 0 0 1 1 1 1 Proteasome stabiliser HEAT PF02985.17 EFW99889.1 - 0.00028 20.7 7.8 1.3 9.3 0.0 8.4 11 0 0 11 11 11 1 HEAT repeat BRF1 PF07741.8 EFW99889.1 - 0.021 15.0 1.4 0.7 10.1 0.0 3.4 3 0 0 3 3 3 0 Brf1-like TBP-binding domain Adaptin_N PF01602.15 EFW99889.1 - 0.035 12.4 0.0 0.47 8.7 0.0 2.5 2 0 0 2 2 2 0 Adaptin N terminal region HEAT_EZ PF13513.1 EFW99889.1 - 0.08 13.4 0.1 0.08 13.4 0.1 7.8 8 0 0 8 8 8 0 HEAT-like repeat V4R PF02830.13 EFW99889.1 - 0.17 11.7 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 V4R domain FA_desaturase PF00487.19 EFW99890.1 - 3.7e-24 85.5 16.0 5.7e-24 84.9 11.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 EFW99890.1 - 4.4e-08 33.2 0.0 7.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Prenyltrans PF00432.16 EFW99891.1 - 6.5e-42 140.7 9.0 6.4e-12 44.8 0.0 6.3 6 2 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EFW99891.1 - 1.8e-24 86.2 0.0 4.9e-15 55.9 0.0 4.4 2 2 2 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 EFW99891.1 - 8.4e-09 35.4 0.0 0.62 10.0 0.0 4.9 2 1 1 4 4 4 3 Prenyltransferase-like Cytochrom_C550 PF14495.1 EFW99891.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c-550 domain NmrA PF05368.8 EFW99892.1 - 4.2e-19 68.7 0.0 5.1e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFW99892.1 - 0.0038 17.2 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EFW99892.1 - 0.013 15.1 0.1 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.20 EFW99892.1 - 0.034 14.0 0.8 0.1 12.5 0.1 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Semialdhyde_dh PF01118.19 EFW99892.1 - 0.078 13.2 0.0 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain FAA_hydrolase PF01557.13 EFW99893.1 - 2.5e-60 203.6 0.0 3.3e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family SLX9 PF15341.1 EFW99895.1 - 3.5e-31 108.1 2.1 4.9e-31 107.6 1.5 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DUF4246 PF14033.1 EFW99896.1 - 6.1e-76 256.0 1.5 7e-46 156.8 0.0 3.6 2 1 2 4 4 4 3 Protein of unknown function (DUF4246) Shadoo PF14999.1 EFW99900.1 - 2 8.2 4.5 8.7 6.2 0.3 3.2 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective Peptidase_C14 PF00656.17 EFW99901.1 - 5.1e-71 239.2 0.0 6.8e-71 238.8 0.0 1.0 1 0 0 1 1 1 1 Caspase domain KAR PF15222.1 EFW99901.1 - 0.085 12.9 0.1 0.24 11.4 0.1 1.7 1 0 0 1 1 1 0 Kidney androgen-regulated Raptor_N PF14538.1 EFW99901.1 - 0.16 11.8 0.5 0.65 9.8 0.0 2.1 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain DUF1191 PF06697.7 EFW99902.1 - 0.00023 20.1 0.1 0.00041 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) PilX PF13681.1 EFW99902.1 - 0.079 13.4 0.1 0.079 13.4 0.1 4.2 4 1 0 4 4 4 0 Type IV pilus assembly protein PilX C-term Amnionless PF14828.1 EFW99902.1 - 0.083 11.3 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Amnionless SKG6 PF08693.5 EFW99902.1 - 0.77 9.1 6.2 0.071 12.4 0.3 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain MPC PF03650.8 EFW99904.1 - 6.4e-34 116.4 0.3 7.3e-34 116.2 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) End_beta_barrel PF12195.3 EFW99904.1 - 0.012 15.2 0.1 1.3 8.7 0.0 2.5 1 1 1 2 2 2 0 Beta barrel domain of bacteriophage endosialidase MtN3_slv PF03083.11 EFW99904.1 - 0.065 13.1 0.8 0.12 12.2 0.6 1.5 1 1 0 1 1 1 0 Sugar efflux transporter for intercellular exchange DAP3 PF10236.4 EFW99906.1 - 6.8e-82 274.8 0.0 8.3e-82 274.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 S-methyl_trans PF02574.11 EFW99907.1 - 6.7e-22 78.1 0.0 4e-15 55.9 0.0 2.1 2 0 0 2 2 2 2 Homocysteine S-methyltransferase Ank_2 PF12796.2 EFW99908.1 - 5e-101 331.2 14.5 1.3e-21 76.7 0.5 6.3 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99908.1 - 1.9e-90 292.4 13.8 6.2e-10 38.3 0.0 12.3 12 0 0 12 12 12 10 Ankyrin repeat Ank_3 PF13606.1 EFW99908.1 - 1.1e-66 214.1 6.2 1.2e-06 28.1 0.0 11.6 11 0 0 11 11 11 10 Ankyrin repeat Ank_5 PF13857.1 EFW99908.1 - 8.1e-63 207.0 12.0 2.7e-10 40.1 0.1 10.0 2 2 8 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFW99908.1 - 4.4e-60 199.0 6.3 3.4e-11 43.3 0.0 8.0 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Peptidase_S8 PF00082.17 EFW99908.1 - 6.2e-14 51.8 0.7 2.4e-13 49.8 0.5 2.0 1 1 0 1 1 1 1 Subtilase family Prenyltrans PF00432.16 EFW99909.1 - 1.3e-59 197.4 10.2 1.7e-13 49.8 0.1 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EFW99909.1 - 3.7e-39 133.6 0.0 1.5e-15 57.5 0.0 4.0 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 EFW99909.1 - 2.7e-11 43.4 0.0 0.00014 21.8 0.0 3.4 3 1 0 3 3 3 2 Prenyltransferase-like PhyH PF05721.8 EFW99910.1 - 5.5e-09 36.3 1.3 2e-07 31.2 0.9 2.2 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) MFS_1 PF07690.11 EFW99912.1 - 4.5e-31 107.8 40.8 9.1e-30 103.5 22.1 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 EFW99912.1 - 3.3e-08 32.1 5.5 3.3e-08 32.1 3.8 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Nop14 PF04147.7 EFW99913.1 - 3e-210 700.3 28.9 6.9e-116 388.1 0.0 2.2 1 1 1 2 2 2 2 Nop14-like family Chromo PF00385.19 EFW99914.1 - 1.1e-07 31.3 0.0 3.1e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Zn_clus PF00172.13 EFW99915.1 - 1e-06 28.4 9.1 2.2e-06 27.4 6.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_trans_4_4 PF13579.1 EFW99915.1 - 0.016 15.3 2.5 0.016 15.3 1.8 1.9 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain SNF2_N PF00176.18 EFW99916.1 - 7.4e-68 228.5 0.0 9.8e-68 228.1 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.5 EFW99916.1 - 1.5e-57 194.5 0.7 3.1e-57 193.5 0.5 1.5 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.26 EFW99916.1 - 9.8e-12 44.5 0.0 2.6e-11 43.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EFW99916.1 - 0.00018 20.4 0.0 0.00052 18.9 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 EFW99916.1 - 0.0014 18.5 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFW99916.1 - 0.046 13.8 0.0 0.29 11.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain Ank_2 PF12796.2 EFW99917.1 - 1.9e-204 662.7 0.0 1.4e-18 67.0 0.0 10.3 1 1 14 15 15 15 15 Ankyrin repeats (3 copies) Ank PF00023.25 EFW99917.1 - 8.2e-116 372.5 0.0 2.9e-05 23.6 0.0 19.7 20 0 0 20 20 20 18 Ankyrin repeat Ank_5 PF13857.1 EFW99917.1 - 1.8e-111 361.6 1.9 3.6e-11 42.9 0.0 17.9 4 2 14 18 18 18 17 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFW99917.1 - 2.4e-105 343.2 0.6 8.7e-09 35.6 0.0 14.8 4 2 12 16 16 16 15 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFW99917.1 - 2.7e-90 287.1 0.0 0.0014 18.7 0.0 18.6 18 0 0 18 18 18 18 Ankyrin repeat NACHT PF05729.7 EFW99917.1 - 2.4e-07 30.5 0.6 2.1e-06 27.4 0.0 2.6 2 1 0 2 2 2 1 NACHT domain DUF2384 PF09722.5 EFW99917.1 - 2e-05 24.3 1.2 2e+02 1.9 0.0 9.4 13 0 0 13 13 13 0 Protein of unknown function (DUF2384) AAA_16 PF13191.1 EFW99917.1 - 4.5e-05 23.5 0.1 0.00019 21.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain PGAP1 PF07819.8 EFW99917.1 - 5e-05 22.9 0.0 9.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 EFW99917.1 - 0.00014 21.1 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) AAA_22 PF13401.1 EFW99917.1 - 0.00071 19.7 0.0 0.0028 17.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain Abhydrolase_5 PF12695.2 EFW99917.1 - 0.0027 17.4 0.0 0.014 15.1 0.0 2.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family AAA_29 PF13555.1 EFW99917.1 - 0.052 13.0 0.2 0.14 11.7 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arch_ATPase PF01637.13 EFW99917.1 - 0.26 10.9 0.0 0.5 10.0 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase Amino_oxidase PF01593.19 EFW99918.1 - 1.8e-11 43.8 0.2 4.5e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.19 EFW99918.1 - 6.8e-09 35.0 1.1 4.8e-06 25.7 0.2 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFW99918.1 - 9.8e-09 35.1 1.0 2.8e-08 33.6 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFW99918.1 - 0.0011 19.3 0.0 0.049 14.0 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFW99918.1 - 0.03 14.1 0.0 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFW99918.1 - 0.12 11.0 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Mt_ATP-synt_B PF05405.9 EFW99919.1 - 6.2e-48 162.3 9.0 7.6e-48 162.0 6.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Ribosomal_L6e PF01159.14 EFW99919.1 - 0.03 14.5 2.7 0.051 13.8 1.8 1.4 1 0 0 1 1 1 0 Ribosomal protein L6e Rep_trans PF02486.14 EFW99919.1 - 0.052 13.0 0.5 0.052 13.0 0.3 1.5 2 0 0 2 2 2 0 Replication initiation factor Dak2 PF02734.12 EFW99919.1 - 0.26 10.9 3.2 0.35 10.5 1.4 1.8 1 1 0 1 1 1 0 DAK2 domain adh_short PF00106.20 EFW99920.1 - 1.3e-22 80.5 0.8 1.7e-22 80.1 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFW99920.1 - 4.7e-22 78.9 0.0 6e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFW99920.1 - 0.0013 18.4 0.3 0.0021 17.7 0.2 1.3 1 1 0 1 1 1 1 KR domain DUF4425 PF14466.1 EFW99920.1 - 0.056 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4425) 3HCDH_N PF02737.13 EFW99920.1 - 0.12 11.9 0.4 0.25 10.9 0.1 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MutS_V PF00488.16 EFW99922.1 - 6e-56 189.4 1.1 7.3e-38 130.2 0.1 2.4 3 0 0 3 3 3 2 MutS domain V MutS_III PF05192.13 EFW99922.1 - 8.8e-13 48.5 3.9 9.4e-13 48.4 0.4 2.1 1 1 1 2 2 2 1 MutS domain III MutS_II PF05188.12 EFW99922.1 - 6.1e-06 26.3 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.1 EFW99922.1 - 0.0027 17.2 0.0 0.0065 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain GCV_T_C PF08669.6 EFW99922.1 - 0.0064 16.4 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain AAA_23 PF13476.1 EFW99922.1 - 0.039 14.2 0.0 0.065 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 EFW99922.1 - 0.14 11.3 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.1 EFW99922.1 - 0.16 11.5 0.0 1.3 8.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain DnaJ PF00226.26 EFW99923.1 - 5.1e-09 35.7 0.1 1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain SpoIIE PF07228.7 EFW99923.1 - 0.028 14.1 2.2 0.044 13.4 0.4 1.9 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Syntaxin PF00804.20 EFW99924.1 - 0.3 11.2 2.1 6.8 6.9 0.3 3.0 2 0 0 2 2 2 0 Syntaxin HpcH_HpaI PF03328.9 EFW99925.1 - 2.8e-41 140.8 0.2 3.8e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP_mutase PF13714.1 EFW99925.1 - 0.089 11.9 1.9 1.2 8.3 0.1 3.0 2 1 0 3 3 3 0 Phosphoenolpyruvate phosphomutase CBS PF00571.23 EFW99926.1 - 2.1e-16 59.4 1.5 1.5e-05 24.6 0.1 4.5 4 0 0 4 4 4 4 CBS domain DUF2828 PF11443.3 EFW99928.1 - 6.1e-60 202.9 0.0 6.6e-60 202.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Glyco_hydro_72 PF03198.9 EFW99928.1 - 0.075 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Aldo_ket_red PF00248.16 EFW99929.1 - 1.4e-36 125.7 0.0 2.3e-36 125.0 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family HET PF06985.6 EFW99930.1 - 8.2e-23 81.1 3.4 2.9e-22 79.3 2.3 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Asp PF00026.18 EFW99931.1 - 2e-51 175.1 8.9 1.6e-50 172.1 6.1 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFW99931.1 - 1.5e-06 28.2 0.1 1.5e-06 28.2 0.1 3.4 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Zip PF02535.17 EFW99932.1 - 1.9e-54 184.8 4.7 2.8e-54 184.2 3.3 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter LEM PF03020.10 EFW99932.1 - 0.17 11.3 0.0 7.3 6.1 0.0 2.3 2 0 0 2 2 2 0 LEM domain RAI1 PF08652.6 EFW99933.1 - 2.2e-27 94.6 0.0 3.8e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease PfkB PF00294.19 EFW99934.1 - 2.1e-05 23.8 0.5 0.0024 17.0 0.4 2.6 3 0 0 3 3 3 2 pfkB family carbohydrate kinase PIG-L PF02585.12 EFW99935.1 - 2.9e-25 89.2 0.0 5e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase NatB_MDM20 PF09797.4 EFW99937.1 - 1.1e-54 185.5 0.0 1.8e-54 184.8 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.1 EFW99937.1 - 0.0017 18.6 0.7 0.0085 16.4 0.3 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat PTCB-BRCT PF12738.2 EFW99938.1 - 2.1e-43 145.9 0.5 5.4e-20 71.0 0.0 4.3 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.21 EFW99938.1 - 8.6e-38 128.3 0.0 2.6e-14 53.1 0.0 4.4 4 0 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain HET PF06985.6 EFW99939.1 - 1.4e-31 109.5 0.0 2e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Methyltransf_2 PF00891.13 EFW99940.1 - 2.2e-25 89.2 0.0 7.5e-25 87.5 0.0 1.9 1 1 1 2 2 2 1 O-methyltransferase Rrf2 PF02082.15 EFW99940.1 - 0.14 12.2 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator Hexapep PF00132.19 EFW99941.1 - 1.7e-07 30.3 8.3 0.002 17.5 0.1 3.8 1 1 3 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 EFW99941.1 - 8.6e-05 21.9 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.1 EFW99941.1 - 0.0004 19.8 10.3 0.024 14.1 2.8 3.4 1 1 2 3 3 3 3 Hexapeptide repeat of succinyl-transferase W2 PF02020.13 EFW99941.1 - 0.0075 16.1 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Fucokinase PF07959.7 EFW99941.1 - 0.32 9.5 3.4 1.4 7.4 0.2 2.1 1 1 1 2 2 2 0 L-fucokinase IBR PF01485.16 EFW99942.1 - 9.3e-10 38.2 20.1 6.4e-05 22.7 8.3 2.8 2 0 0 2 2 2 2 IBR domain Erv26 PF04148.8 EFW99943.1 - 7e-23 81.1 0.0 7.6e-23 80.9 0.0 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 RRM_1 PF00076.17 EFW99944.1 - 1.2e-15 56.9 0.0 1.9e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99944.1 - 9.6e-10 38.3 0.0 1.5e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99944.1 - 0.089 12.6 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 EFW99944.1 - 0.67 10.4 36.7 0.031 14.6 16.7 4.1 3 1 1 4 4 4 0 C-terminal duplication domain of Friend of PRMT1 CorA PF01544.13 EFW99945.1 - 2.4e-40 138.3 0.1 3.9e-19 68.7 0.0 2.3 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Rsc14 PF08586.5 EFW99945.1 - 0.015 15.7 0.6 2.2 8.8 0.0 2.6 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Guanylate_kin PF00625.16 EFW99945.1 - 0.14 11.5 0.1 0.37 10.1 0.1 1.6 1 0 0 1 1 1 0 Guanylate kinase SNF2_N PF00176.18 EFW99946.1 - 6.6e-70 235.2 0.0 9.2e-70 234.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFW99946.1 - 4.9e-15 55.1 0.0 1.1e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3328 PF11807.3 EFW99947.1 - 1.5e-12 47.6 0.1 2e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TPR_12 PF13424.1 EFW99948.1 - 3.5e-122 398.5 9.7 3e-20 71.9 0.0 5.2 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.1 EFW99948.1 - 1.3e-102 333.2 2.8 4.2e-14 51.9 0.0 8.6 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_2 PF07719.12 EFW99948.1 - 3.2e-28 95.3 2.7 0.04 13.8 0.0 8.5 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.1 EFW99948.1 - 1.3e-26 90.2 9.6 0.0033 17.0 0.0 7.6 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_1 PF00515.23 EFW99948.1 - 2.6e-24 83.7 2.9 0.073 12.7 0.0 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 EFW99948.1 - 1.9e-23 81.8 1.9 5.8e-05 22.6 0.1 5.0 4 1 1 5 5 5 5 TPR repeat TPR_17 PF13431.1 EFW99948.1 - 3.3e-22 76.7 0.6 0.064 13.4 0.0 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 EFW99948.1 - 5.2e-20 71.5 3.7 0.00071 20.1 0.4 6.1 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_4 PF07721.9 EFW99948.1 - 1.6e-19 68.2 0.0 0.59 10.7 0.0 7.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.1 EFW99948.1 - 1.8e-15 57.0 6.8 0.0041 17.4 0.0 7.7 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 EFW99948.1 - 2.1e-15 56.0 9.1 0.23 12.0 0.0 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 EFW99948.1 - 1.3e-13 49.6 10.9 0.85 9.5 0.0 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 EFW99948.1 - 2.1e-13 49.5 17.0 1 10.1 0.0 8.6 7 2 2 9 9 8 5 Tetratricopeptide repeat Apc3 PF12895.2 EFW99948.1 - 2.7e-12 46.6 0.3 0.011 15.8 0.0 5.2 1 1 5 6 6 6 6 Anaphase-promoting complex, cyclosome, subunit 3 NB-ARC PF00931.17 EFW99948.1 - 4.7e-11 42.0 0.0 7.7e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain DUF4074 PF13293.1 EFW99948.1 - 8.8e-10 38.6 0.0 2.2 8.5 0.0 6.6 3 2 3 6 6 6 1 Domain of unknown function (DUF4074) PPR PF01535.15 EFW99948.1 - 2.8e-09 36.3 0.4 5.2 7.2 0.0 7.0 6 0 0 6 6 6 1 PPR repeat AAA_22 PF13401.1 EFW99948.1 - 2.1e-06 27.8 0.0 1.3e-05 25.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 EFW99948.1 - 1.7e-05 24.5 0.0 3.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PPR_3 PF13812.1 EFW99948.1 - 3.3e-05 23.8 3.3 12 6.4 0.0 6.9 7 0 0 7 7 7 0 Pentatricopeptide repeat domain AAA_16 PF13191.1 EFW99948.1 - 6.6e-05 22.9 0.3 0.019 14.9 0.2 3.7 2 2 0 2 2 2 1 AAA ATPase domain DUF2508 PF10704.4 EFW99948.1 - 0.0014 18.7 5.1 36 4.6 0.0 6.0 6 0 0 6 6 6 0 Protein of unknown function (DUF2508) TPR_3 PF07720.7 EFW99948.1 - 0.0089 15.8 0.0 9 6.2 0.0 5.2 7 0 0 7 7 6 0 Tetratricopeptide repeat AAA_14 PF13173.1 EFW99948.1 - 0.013 15.3 0.5 0.031 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Rab5-bind PF09311.6 EFW99948.1 - 0.31 10.8 6.7 15 5.4 0.0 4.4 2 1 2 5 5 5 0 Rabaptin-like protein DUF1897 PF09005.5 EFW99948.1 - 6.3 6.3 13.4 28 4.2 0.1 5.7 6 0 0 6 6 6 0 Domain of unknown function (DUF1897) Gaa1 PF04114.9 EFW99949.1 - 2.1e-93 313.7 10.9 2.1e-55 188.3 4.1 2.8 2 1 0 2 2 2 2 Gaa1-like, GPI transamidase component Rhomboid PF01694.17 EFW99949.1 - 1.2e-13 51.3 13.0 1.2e-13 51.3 9.0 3.4 3 0 0 3 3 3 1 Rhomboid family UreF PF01730.11 EFW99949.1 - 0.52 10.4 5.3 0.18 11.9 0.8 2.3 2 0 0 2 2 2 0 UreF Polysacc_deac_1 PF01522.16 EFW99950.1 - 2.7e-25 88.3 0.0 4.6e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Peptidase_A4 PF01828.12 EFW99951.1 - 4.7e-65 218.5 18.0 5.7e-65 218.2 12.5 1.1 1 0 0 1 1 1 1 Peptidase A4 family MLANA PF14991.1 EFW99952.1 - 0.03 14.3 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein melan-A TrbC PF04956.8 EFW99952.1 - 0.038 14.0 0.7 0.077 13.0 0.5 1.5 1 0 0 1 1 1 0 TrbC/VIRB2 family DUF2910 PF11139.3 EFW99952.1 - 0.086 11.9 0.2 0.086 11.9 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2910) DUF2976 PF11190.3 EFW99952.1 - 0.087 12.3 0.7 0.2 11.2 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) RRM_1 PF00076.17 EFW99953.1 - 5.7e-47 157.2 0.0 1.5e-16 59.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFW99953.1 - 1.7e-24 85.5 0.0 5.8e-10 39.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFW99953.1 - 1.1e-20 73.1 0.0 1.2e-08 34.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFW99953.1 - 8.7e-06 25.5 0.0 0.00014 21.6 0.0 2.5 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.1 EFW99953.1 - 0.0001 22.0 0.1 0.0032 17.2 0.0 2.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif FAA_hydrolase PF01557.13 EFW99954.1 - 1.3e-50 171.9 0.0 1.8e-50 171.4 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 EFW99954.1 - 6.4e-18 64.7 0.0 1e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal CN_hydrolase PF00795.17 EFW99955.1 - 8.7e-10 38.2 0.0 1.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase IF-2B PF01008.12 EFW99958.1 - 2.7e-71 239.8 0.4 3.2e-71 239.6 0.3 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DNase-RNase PF02577.9 EFW99958.1 - 0.079 12.1 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Bifunctional nuclease MFS_1 PF07690.11 EFW99959.1 - 3e-38 131.4 37.3 2.3e-35 121.9 17.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.8 EFW99959.1 - 2.7e-24 85.7 0.0 4.4e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Sugar_tr PF00083.19 EFW99959.1 - 3.1e-11 42.5 5.7 3.1e-11 42.5 4.0 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter Esterase PF00756.15 EFW99959.1 - 1.9e-10 40.5 0.0 1.4e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.2 EFW99959.1 - 4e-05 23.6 2.6 4e-05 23.6 1.8 2.9 2 2 1 3 3 3 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFW99959.1 - 0.00036 19.7 0.1 0.0011 18.1 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFW99959.1 - 0.0036 17.0 0.3 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFW99959.1 - 0.0085 15.6 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Sec62 PF03839.11 EFW99959.1 - 0.15 11.4 3.8 1.8 7.9 0.1 2.5 2 0 0 2 2 2 0 Translocation protein Sec62 CAP_GLY PF01302.20 EFW99961.1 - 4.8e-15 55.0 0.5 9.8e-15 54.0 0.3 1.5 1 0 0 1 1 1 1 CAP-Gly domain NPV_P10 PF05531.7 EFW99961.1 - 0.0021 18.2 4.1 0.47 10.7 0.6 2.7 2 0 0 2 2 2 2 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.1 EFW99961.1 - 0.016 13.7 10.4 0.0039 15.7 3.8 1.9 1 1 0 2 2 2 0 AAA domain BLOC1_2 PF10046.4 EFW99961.1 - 0.031 14.4 13.9 0.076 13.1 2.8 3.5 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 EFW99961.1 - 0.042 13.0 0.9 1.4 7.9 0.2 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Zn_ribbon_2 PF12674.2 EFW99961.1 - 0.15 12.3 1.5 7 7.0 0.0 2.8 2 0 0 2 2 2 0 Putative zinc ribbon domain FliD_N PF02465.13 EFW99961.1 - 0.66 10.3 7.5 2 8.8 0.0 3.5 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Spc7 PF08317.6 EFW99961.1 - 0.69 8.5 18.1 0.097 11.3 5.3 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein TBPIP PF07106.8 EFW99961.1 - 0.82 9.2 11.8 5.5 6.5 0.1 2.9 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Glutaredoxin2_C PF04399.8 EFW99961.1 - 0.94 9.0 6.5 13 5.3 0.0 3.0 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain Fzo_mitofusin PF04799.8 EFW99961.1 - 1.8 7.9 5.3 1.4 8.3 0.7 2.6 3 0 0 3 3 3 0 fzo-like conserved region Laminin_II PF06009.7 EFW99961.1 - 2.9 7.6 6.8 1.2 8.8 1.3 2.5 2 0 0 2 2 2 0 Laminin Domain II DUF812 PF05667.6 EFW99961.1 - 3.1 6.2 15.6 2.2 6.6 8.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DASH_Dam1 PF08653.5 EFW99961.1 - 3.7 7.3 4.2 1.4 8.7 0.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 Occludin_ELL PF07303.8 EFW99961.1 - 9.5 7.0 7.9 2.6 8.8 1.2 2.8 2 0 0 2 2 2 0 Occludin homology domain WD40 PF00400.27 EFW99965.1 - 4.6e-46 153.1 15.8 1.8e-05 24.4 0.0 12.0 12 1 0 12 12 12 9 WD domain, G-beta repeat Pox_E10 PF04805.7 EFW99967.1 - 3 7.4 5.3 36 3.9 0.1 3.4 3 0 0 3 3 3 0 E10-like protein conserved region Abhydrolase_6 PF12697.2 EFW99968.1 - 3.4e-11 43.4 1.0 6.7e-11 42.5 0.7 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFW99968.1 - 0.00031 20.5 0.0 0.00067 19.4 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 EFW99968.1 - 0.0019 17.8 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_1 PF00561.15 EFW99968.1 - 0.0036 16.8 0.0 0.0061 16.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_8 PF06259.7 EFW99968.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_5 PF12695.2 EFW99969.1 - 5.2e-24 84.6 0.0 9.1e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFW99969.1 - 1.6e-18 67.4 0.2 3.6e-17 63.0 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFW99969.1 - 2.4e-07 30.5 0.2 0.00083 18.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF818 PF05677.7 EFW99969.1 - 5.8e-06 25.2 0.0 8.1e-06 24.7 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.8 EFW99969.1 - 9.6e-05 21.9 0.0 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 EFW99969.1 - 0.00069 19.1 0.2 0.25 10.7 0.0 2.6 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase DLH PF01738.13 EFW99969.1 - 0.00099 18.4 0.0 0.23 10.7 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.16 EFW99969.1 - 0.001 18.3 0.0 0.011 14.9 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.7 EFW99969.1 - 0.001 17.6 0.6 0.15 10.5 0.0 2.9 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.8 EFW99969.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.6 EFW99969.1 - 0.027 14.1 0.0 6.5 6.3 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.3 EFW99969.1 - 0.047 13.5 0.1 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase PGAP1 PF07819.8 EFW99969.1 - 0.2 11.1 0.1 2.6 7.5 0.1 2.3 2 1 0 2 2 2 0 PGAP1-like protein Fungal_trans PF04082.13 EFW99970.1 - 9.4e-13 47.6 0.7 1.3e-12 47.1 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Rsa3 PF14615.1 EFW99971.1 - 9.8e-22 75.9 0.4 6.2e-16 57.4 0.1 2.1 2 0 0 2 2 2 2 Ribosome-assembly protein 3 DUF3138 PF11336.3 EFW99971.1 - 4.2 5.4 6.1 4.1 5.4 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) SMI1_KNR4 PF09346.5 EFW99972.1 - 5.1e-35 120.3 0.0 8.3e-35 119.6 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) CVNH PF08881.5 EFW99973.1 - 0.00022 21.3 0.0 0.00038 20.6 0.0 1.4 1 0 0 1 1 1 1 CVNH domain Formyl_trans_N PF00551.14 EFW99974.1 - 5.5e-33 114.0 0.0 8.2e-33 113.4 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase MCM PF00493.18 EFW99975.1 - 1.2e-134 448.2 0.0 1.7e-134 447.8 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EFW99975.1 - 1.1e-23 84.0 0.1 3.3e-23 82.4 0.0 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EFW99975.1 - 2e-07 30.4 0.0 1.8e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFW99975.1 - 1.4e-06 28.1 0.0 4.2e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 EFW99975.1 - 0.0043 17.4 0.2 0.017 15.4 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EFW99975.1 - 0.015 14.9 0.0 0.049 13.2 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFW99975.1 - 0.15 11.5 0.1 0.91 8.9 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain DER1 PF04511.10 EFW99976.1 - 2.1e-15 56.7 1.9 2.6e-15 56.4 0.4 1.6 1 1 1 2 2 2 1 Der1-like family zf-LYAR PF08790.6 EFW99977.1 - 8.2e-14 51.0 5.0 8.2e-14 51.0 3.4 2.0 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger Macoilin PF09726.4 EFW99977.1 - 3.5 5.7 11.8 6.5 4.9 8.2 1.4 1 0 0 1 1 1 0 Transmembrane protein DDRGK PF09756.4 EFW99977.1 - 8.2 5.7 11.1 0.26 10.6 3.1 1.9 2 0 0 2 2 2 0 DDRGK domain Zip PF02535.17 EFW99977.1 - 9.4 5.1 12.0 17 4.2 8.3 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Ytp1 PF10355.4 EFW99978.1 - 3.7e-109 364.0 6.8 3.7e-109 364.0 4.7 1.7 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EFW99978.1 - 2.3e-31 107.4 5.5 2.3e-31 107.4 3.8 3.6 4 0 0 4 4 4 2 Domain of unknown function (DUF2427) MFS_1 PF07690.11 EFW99979.1 - 5.1e-05 22.1 1.7 6.8e-05 21.7 1.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sensor PF13796.1 EFW99979.1 - 0.018 14.6 2.2 0.025 14.1 0.2 2.0 2 0 0 2 2 2 0 Putative sensor DUF1228 PF06779.9 EFW99979.1 - 0.082 12.9 0.8 0.26 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) Sel1 PF08238.7 EFW99980.1 - 2.1e-12 47.2 0.3 1.9e-06 28.3 0.0 2.7 2 0 0 2 2 2 2 Sel1 repeat Corona_nucleoca PF00937.13 EFW99980.1 - 5.1 5.9 11.7 0.34 9.8 3.1 2.2 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein PI-PLC-X PF00388.14 EFW99981.1 - 2.4e-61 205.4 0.0 4.5e-61 204.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EFW99981.1 - 2.7e-34 117.6 0.1 6e-34 116.5 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 EFW99981.1 - 4.4e-08 32.8 0.0 9.6e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.6 EFW99981.1 - 0.00078 19.4 0.0 0.0038 17.2 0.0 2.1 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like Cupin_5 PF06172.6 EFW99982.1 - 4.5e-43 146.5 0.0 5.2e-43 146.2 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) SNF2_N PF00176.18 EFW99983.1 - 3.6e-74 249.2 0.4 6.2e-74 248.4 0.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFW99983.1 - 2e-14 53.2 0.1 4.3e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFW99983.1 - 7.3e-08 32.4 0.0 1.6e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.8 EFW99983.1 - 0.00064 19.4 3.8 0.00064 19.4 2.6 2.2 2 0 0 2 2 2 1 HSA HDA2-3 PF11496.3 EFW99983.1 - 0.0012 17.7 0.1 0.32 9.7 0.0 2.4 2 0 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 DEAD_2 PF06733.10 EFW99983.1 - 0.27 10.6 0.0 0.56 9.5 0.0 1.4 1 0 0 1 1 1 0 DEAD_2 Cpn60_TCP1 PF00118.19 EFW99984.1 - 6.5e-127 424.0 7.3 8.4e-127 423.7 5.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fes1 PF08609.5 EFW99986.1 - 3.1e-31 107.7 0.7 7.7e-31 106.4 0.5 1.7 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 EFW99986.1 - 2e-06 27.9 8.4 0.00048 20.3 1.0 2.3 1 1 1 2 2 2 2 HEAT repeats Arm PF00514.18 EFW99986.1 - 0.00031 20.4 5.6 0.0024 17.6 0.0 3.1 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 EFW99986.1 - 0.0011 19.4 0.7 0.0011 19.4 0.5 3.3 2 1 2 4 4 4 3 HEAT-like repeat ATP13 PF12921.2 EFW99987.1 - 3.9e-21 74.6 0.1 5.7e-20 70.9 0.0 2.7 3 0 0 3 3 3 1 Mitochondrial ATPase expression OmdA PF13376.1 EFW99987.1 - 0.0013 18.2 0.3 0.031 13.9 0.0 2.4 2 0 0 2 2 2 1 Bacteriocin-protection, YdeI or OmpD-Associated PPR_2 PF13041.1 EFW99987.1 - 0.13 12.2 0.0 14 5.7 0.0 3.1 3 0 0 3 3 3 0 PPR repeat family PPR_3 PF13812.1 EFW99987.1 - 0.9 9.9 3.7 53 4.4 0.1 3.7 4 0 0 4 4 4 0 Pentatricopeptide repeat domain SAC3_GANP PF03399.11 EFW99988.1 - 2.6e-40 138.1 0.0 3.9e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PROCN PF08083.6 EFW99989.1 - 2e-216 718.1 6.0 3.2e-216 717.5 4.2 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 EFW99989.1 - 1.7e-124 413.6 1.1 2.9e-124 412.8 0.7 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 EFW99989.1 - 5.2e-94 311.9 0.0 8.9e-59 197.4 0.0 2.8 2 0 0 2 2 2 2 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 EFW99989.1 - 2.3e-77 257.8 2.6 2.3e-77 257.8 1.8 1.9 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 EFW99989.1 - 1.3e-66 222.3 0.1 2.7e-66 221.3 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.4 EFW99989.1 - 3e-43 145.5 0.1 7.2e-43 144.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.6 EFW99989.1 - 2.5e-41 140.2 0.3 6.1e-41 139.0 0.0 1.9 2 0 0 2 2 2 1 PROCT (NUC072) domain Hom_end_hint PF05203.11 EFW99989.1 - 2.1e-36 125.7 9.7 2.8e-35 121.9 0.5 3.9 2 1 0 2 2 2 1 Hom_end-associated Hint DUF3753 PF12575.3 EFW99989.1 - 0.15 11.9 0.0 0.39 10.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) WBS_methylT PF12589.3 EFW99991.1 - 2.2e-16 60.0 1.9 5.1e-16 58.9 1.3 1.7 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 EFW99991.1 - 1.3e-07 32.0 0.0 2.3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99991.1 - 0.033 14.6 0.0 0.081 13.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain UDP-g_GGTase PF06427.6 EFW99992.1 - 3.8e-54 183.2 0.0 7.1e-54 182.3 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 EFW99992.1 - 1.4e-05 24.5 0.0 2.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Metallopep PF12044.3 EFW99993.1 - 3.6e-162 539.6 0.0 4.5e-162 539.3 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 EFW99993.1 - 6.5e-06 26.0 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain SQS_PSY PF00494.14 EFW99994.1 - 6e-52 176.5 2.5 9.2e-52 175.9 1.8 1.3 1 1 0 1 1 1 1 Squalene/phytoene synthase DUF2984 PF11203.3 EFW99994.1 - 0.058 13.4 0.4 0.51 10.4 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2984) LSM PF01423.17 EFW99996.1 - 1.5e-17 62.9 0.0 2.3e-17 62.2 0.0 1.3 1 1 0 1 1 1 1 LSM domain zf-C3HC4_3 PF13920.1 EFW99997.1 - 2.4e-05 23.9 9.7 2.4e-05 23.9 6.8 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFW99997.1 - 3.3 7.8 23.6 0.056 13.4 8.7 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Na_Ca_ex PF01699.19 EFW99998.1 - 7.9e-33 113.0 36.7 8.2e-21 74.0 8.7 3.4 3 1 0 3 3 3 2 Sodium/calcium exchanger protein SR-25 PF10500.4 EFW99998.1 - 0.26 10.7 16.8 0.12 11.7 6.8 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Methyltransf_11 PF08241.7 EFW99999.1 - 2.5e-19 69.5 0.0 4.7e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFW99999.1 - 2.1e-15 56.6 0.0 3.3e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFW99999.1 - 2.5e-13 50.3 0.0 4.2e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFW99999.1 - 8.4e-13 47.9 0.0 1.8e-12 46.9 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 EFW99999.1 - 2.4e-11 43.6 0.0 3.9e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFW99999.1 - 5.2e-11 42.7 0.0 1e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFW99999.1 - 8e-11 42.5 0.0 1.5e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFW99999.1 - 3.4e-10 39.4 0.0 5e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 EFW99999.1 - 5.9e-10 39.1 0.0 1.5e-09 37.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFW99999.1 - 4.7e-06 26.0 0.0 8e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EFW99999.1 - 0.00019 20.6 0.0 0.00038 19.6 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.7 EFW99999.1 - 0.00029 20.2 0.0 0.00051 19.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW RrnaAD PF00398.15 EFW99999.1 - 0.00083 18.4 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.14 EFW99999.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 EFW99999.1 - 0.007 15.4 0.0 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_8 PF05148.10 EFW99999.1 - 0.018 14.6 0.0 0.22 11.1 0.0 2.2 1 1 0 1 1 1 0 Hypothetical methyltransferase FmrO PF07091.6 EFW99999.1 - 0.034 13.1 0.0 0.092 11.7 0.0 1.4 1 1 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) DOT1 PF08123.8 EFW99999.1 - 0.051 12.8 0.0 0.096 11.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 TehB PF03848.9 EFW99999.1 - 0.065 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.1 EFW99999.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SKG6 PF08693.5 EFX00001.1 - 0.0083 15.4 3.1 0.017 14.4 2.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4293 PF14126.1 EFX00001.1 - 0.024 14.5 0.3 0.039 13.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) Syndecan PF01034.15 EFX00001.1 - 0.21 11.2 1.2 0.42 10.2 0.8 1.4 1 0 0 1 1 1 0 Syndecan domain DUF221 PF02714.10 EFX00002.1 - 4.7e-93 311.5 15.0 7.3e-93 310.9 10.4 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF221 2-Hacid_dh_C PF02826.14 EFX00002.1 - 2.2e-47 160.5 0.2 3.9e-30 104.3 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RSN1_TM PF13967.1 EFX00002.1 - 2.6e-40 137.5 5.7 2.6e-40 137.5 4.0 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport 2-Hacid_dh PF00389.25 EFX00002.1 - 6.1e-24 83.9 0.0 1.2e-23 82.9 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain DUF4463 PF14703.1 EFX00002.1 - 2e-14 53.8 0.1 3.9e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) NAD_binding_2 PF03446.10 EFX00002.1 - 0.006 16.4 0.0 0.028 14.2 0.0 2.0 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_18 PF12847.2 EFX00002.1 - 0.11 13.0 0.0 0.39 11.3 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain AAA PF00004.24 EFX00003.1 - 1.4e-51 174.1 0.0 1.9e-42 144.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 EFX00003.1 - 1.9e-26 91.9 0.3 3.7e-26 90.9 0.2 1.5 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 EFX00003.1 - 3.1e-11 43.5 7.1 1.6e-07 31.4 0.1 4.7 3 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.1 EFX00003.1 - 5.3e-06 26.5 0.3 0.11 12.6 0.0 3.7 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EFX00003.1 - 7.2e-06 25.7 0.1 0.027 14.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) NACHT PF05729.7 EFX00003.1 - 0.00015 21.4 1.2 0.039 13.6 0.0 3.4 3 1 0 3 3 3 1 NACHT domain AAA_19 PF13245.1 EFX00003.1 - 0.00022 20.8 0.0 0.34 10.7 0.0 3.3 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 EFX00003.1 - 0.00033 20.5 0.1 1.1 9.1 0.0 3.0 2 1 0 2 2 2 2 AAA domain KAP_NTPase PF07693.9 EFX00003.1 - 0.00033 19.7 0.6 0.42 9.5 0.0 2.4 1 1 1 2 2 2 2 KAP family P-loop domain AAA_17 PF13207.1 EFX00003.1 - 0.00082 20.1 0.6 0.79 10.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EFX00003.1 - 0.00085 18.7 0.3 0.52 9.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFX00003.1 - 0.0013 17.8 0.0 0.48 9.4 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin RuvB_N PF05496.7 EFX00003.1 - 0.0027 16.7 0.0 0.027 13.5 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EFX00003.1 - 0.0036 17.2 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 EFX00003.1 - 0.004 17.0 0.0 0.52 10.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 EFX00003.1 - 0.0041 17.4 0.6 1.4 9.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 EFX00003.1 - 0.0064 15.9 3.7 1.7 8.0 0.0 4.0 2 2 2 4 4 4 1 AAA domain UPF0079 PF02367.12 EFX00003.1 - 0.0073 15.9 0.1 0.063 12.9 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 EFX00003.1 - 0.012 14.8 0.3 2.7 7.1 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.1 EFX00003.1 - 0.013 15.5 0.0 0.92 9.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain TIP49 PF06068.8 EFX00003.1 - 0.02 13.6 0.1 3.2 6.3 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus DUF815 PF05673.8 EFX00003.1 - 0.028 13.3 0.0 0.16 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.17 EFX00003.1 - 0.035 14.2 0.0 14 5.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Peptidase_M41 PF01434.13 EFX00003.1 - 0.042 13.3 0.1 0.074 12.5 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M41 Sigma54_activat PF00158.21 EFX00003.1 - 0.048 13.1 0.0 0.53 9.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain KaiC PF06745.8 EFX00003.1 - 0.071 12.2 0.2 5.5 6.0 0.0 2.4 2 0 0 2 2 2 0 KaiC AAA_29 PF13555.1 EFX00003.1 - 0.077 12.5 0.3 0.32 10.5 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.22 EFX00003.1 - 0.083 13.1 0.1 5.2 7.3 0.1 2.7 2 0 0 2 2 2 0 ABC transporter Arch_ATPase PF01637.13 EFX00003.1 - 0.11 12.1 0.1 3.8 7.1 0.0 2.7 2 1 1 3 3 3 0 Archaeal ATPase DAP3 PF10236.4 EFX00003.1 - 0.55 9.1 0.2 5.2 5.9 0.0 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 CDC45 PF02724.9 EFX00003.1 - 1.2 7.0 1.1 2 6.3 0.7 1.2 1 0 0 1 1 1 0 CDC45-like protein p450 PF00067.17 EFX00004.1 - 3e-44 151.2 0.0 1.1e-30 106.6 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 CRAL_TRIO PF00650.15 EFX00005.1 - 4.2e-14 52.3 0.0 6.5e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFX00005.1 - 0.075 13.1 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain GIDE PF12483.3 EFX00005.1 - 0.4 10.0 2.6 0.41 10.0 0.2 2.0 2 0 0 2 2 2 0 E3 Ubiquitin ligase Asp PF00026.18 EFX00006.1 - 2.2e-36 125.7 3.7 2.5e-36 125.5 2.6 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX00006.1 - 6.9e-06 26.1 2.3 6.9e-06 26.1 1.6 1.6 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Iso_dh PF00180.15 EFX00007.1 - 9.8e-81 271.3 0.0 1.2e-80 271.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pneumo_att_G PF05539.6 EFX00008.1 - 0.53 9.6 7.0 0.86 8.9 4.9 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G NDUF_B8 PF05821.6 EFX00009.1 - 0.00026 20.6 0.0 0.00036 20.2 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) SBP_bac_3 PF00497.15 EFX00011.1 - 0.033 13.4 0.1 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Elongin_A PF06881.6 EFX00012.1 - 9.8e-16 58.0 0.0 1.7e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A CBF PF03914.12 EFX00014.1 - 7.4e-45 152.3 0.2 6.2e-44 149.3 0.0 2.4 3 0 0 3 3 3 1 CBF/Mak21 family Tyrosinase PF00264.15 EFX00015.1 - 3.2e-55 187.7 1.9 8.2e-55 186.3 1.3 1.7 1 1 0 1 1 1 1 Common central domain of tyrosinase Ivy PF08816.6 EFX00015.1 - 0.031 14.2 1.4 4.7 7.2 0.1 2.8 2 1 0 2 2 2 0 Inhibitor of vertebrate lysozyme (Ivy) Cyclin PF08613.6 EFX00016.1 - 3.1e-38 131.4 1.2 4.2e-23 82.4 0.2 2.4 2 0 0 2 2 2 2 Cyclin Phage_T4_gp36 PF03903.8 EFX00017.1 - 0.069 13.2 0.1 0.076 13.1 0.1 1.2 1 0 0 1 1 1 0 Phage T4 tail fibre hDGE_amylase PF14701.1 EFX00018.1 - 6.3e-174 578.8 0.0 7.9e-174 578.4 0.0 1.1 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 EFX00018.1 - 9.8e-112 373.3 0.0 1.5e-111 372.6 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 EFX00018.1 - 5.9e-87 291.1 0.0 1.1e-86 290.2 0.0 1.4 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 EFX00018.1 - 1.1e-28 98.8 0.0 2.6e-28 97.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 EFX00018.1 - 2.3e-05 23.9 0.1 0.19 11.0 0.0 2.2 2 0 0 2 2 2 2 Alpha amylase, catalytic domain Zw10 PF06248.8 EFX00019.1 - 1.8e-11 42.9 0.0 0.00022 19.5 0.0 2.8 3 0 0 3 3 3 2 Centromere/kinetochore Zw10 Daxx PF03344.10 EFX00019.1 - 2 6.7 10.1 3 6.2 7.0 1.1 1 0 0 1 1 1 0 Daxx Family MIF4G_like PF09088.6 EFX00021.1 - 3.6e-80 267.8 0.2 6.5e-80 267.0 0.1 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.6 EFX00021.1 - 2.5e-42 144.8 0.0 4e-42 144.2 0.0 1.3 1 0 0 1 1 1 1 MIF4G like Kdo PF06293.9 EFX00022.1 - 9.1e-06 24.8 0.0 1.7e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX00022.1 - 2.2e-05 24.3 7.0 2.4e-05 24.1 0.1 2.7 2 2 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.17 EFX00022.1 - 0.028 13.7 0.0 0.057 12.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family FAD_binding_4 PF01565.18 EFX00023.1 - 3.8e-27 94.4 0.7 7.1e-27 93.5 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX00023.1 - 5.6e-13 48.5 0.2 1.4e-12 47.2 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like NAD_Gly3P_dh_N PF01210.18 EFX00025.1 - 1.7e-46 157.8 0.0 3.1e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 EFX00025.1 - 6e-42 142.8 0.3 8.7e-42 142.3 0.2 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus SopE_GEF PF07487.8 EFX00025.1 - 0.11 12.3 0.0 0.79 9.6 0.0 2.2 2 0 0 2 2 2 0 SopE GEF domain PilP PF04351.8 EFX00026.1 - 0.0085 15.9 0.1 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 Pilus assembly protein, PilP Cyanate_lyase PF02560.9 EFX00028.1 - 5.8e-26 89.8 0.0 8.1e-26 89.3 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.1 EFX00028.1 - 2.7e-07 30.6 0.6 4e-07 30.1 0.4 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain DUF640 PF04852.7 EFX00028.1 - 0.00011 22.3 0.0 0.00015 21.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF640) HTH_3 PF01381.17 EFX00028.1 - 0.00066 19.4 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix Sigma70_r4_2 PF08281.7 EFX00028.1 - 0.016 14.6 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 RPAP1_N PF08621.5 EFX00028.1 - 0.067 12.7 0.2 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 RPAP1-like, N-terminal ADH_N PF08240.7 EFX00029.1 - 1.3e-29 102.1 1.0 2.8e-29 101.0 0.7 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX00029.1 - 2.3e-13 49.8 0.3 2.3e-13 49.8 0.2 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ETF PF01012.16 EFX00029.1 - 0.062 13.0 0.1 7.1 6.3 0.0 2.9 2 1 1 3 3 3 0 Electron transfer flavoprotein domain 2-Hacid_dh_C PF02826.14 EFX00029.1 - 0.087 11.9 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SNF2_N PF00176.18 EFX00030.1 - 5.7e-71 238.7 0.0 8.1e-71 238.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 EFX00030.1 - 5.6e-22 77.6 0.0 1.2e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.26 EFX00030.1 - 1.4e-12 47.2 0.0 4e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 EFX00030.1 - 6e-06 26.1 9.8 6e-06 26.1 6.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX00030.1 - 0.0025 17.4 9.7 0.0025 17.4 6.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.10 EFX00030.1 - 0.013 15.3 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UBA PF00627.26 EFX00030.1 - 0.078 12.8 0.2 5.6 6.9 0.0 2.7 2 0 0 2 2 2 0 UBA/TS-N domain zf-RING_2 PF13639.1 EFX00030.1 - 3.2 7.6 18.4 0.058 13.2 7.7 2.0 2 0 0 2 2 2 0 Ring finger domain SUR7 PF06687.7 EFX00031.1 - 1.9e-07 30.8 8.1 3.1e-07 30.1 5.6 1.3 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EFX00031.1 - 5.6e-07 29.6 12.3 5.6e-07 29.6 8.5 2.3 1 1 1 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 Pilus_PilP PF11356.3 EFX00031.1 - 0.16 12.2 2.3 3 8.1 0.2 2.4 2 0 0 2 2 2 0 Type IV pilus biogenesis DUF962 PF06127.6 EFX00031.1 - 0.16 11.8 1.0 3.9 7.4 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Tetraspannin PF00335.15 EFX00031.1 - 1.8 7.7 6.6 5.8 6.1 0.8 2.4 2 0 0 2 2 2 0 Tetraspanin family DUF4293 PF14126.1 EFX00031.1 - 3.7 7.4 8.5 2.8 7.8 0.1 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4293) WD40 PF00400.27 EFX00034.1 - 2.7e-39 131.6 12.5 7.7e-10 38.2 0.0 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat eIF2A PF08662.6 EFX00034.1 - 0.0002 21.1 0.0 0.066 12.9 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Mnd1 PF03962.10 EFX00034.1 - 0.68 9.5 3.7 0.98 9.0 2.6 1.1 1 0 0 1 1 1 0 Mnd1 family Atg14 PF10186.4 EFX00034.1 - 1.9 7.3 5.6 3.1 6.6 3.9 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Aa_trans PF01490.13 EFX00035.1 - 1.2e-58 198.5 31.4 1.6e-58 198.1 21.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein BAF1_ABF1 PF04684.8 EFX00035.1 - 1.8 7.3 4.5 3.5 6.3 3.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2075 PF09848.4 EFX00036.1 - 5.3e-88 295.3 0.0 7.5e-88 294.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 EFX00036.1 - 6.7e-08 32.7 0.2 1.7e-07 31.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 EFX00036.1 - 1.8e-07 31.2 2.4 5.9e-07 29.6 0.3 2.5 2 1 0 2 2 1 1 AAA ATPase domain DUF258 PF03193.11 EFX00036.1 - 0.00014 21.0 0.1 0.00025 20.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 EFX00036.1 - 0.00021 20.9 0.3 0.0023 17.5 0.2 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 EFX00036.1 - 0.00072 19.4 0.0 0.02 14.7 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EFX00036.1 - 0.0027 17.4 0.0 0.0075 16.0 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 EFX00036.1 - 0.0075 15.2 0.1 0.011 14.6 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA PF00004.24 EFX00036.1 - 0.0098 16.0 0.4 0.05 13.7 0.3 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Septin PF00735.13 EFX00036.1 - 0.014 14.3 0.5 0.024 13.6 0.3 1.2 1 0 0 1 1 1 0 Septin Arch_ATPase PF01637.13 EFX00036.1 - 0.015 15.0 0.4 0.071 12.8 0.3 1.9 1 1 0 1 1 1 0 Archaeal ATPase DUF2514 PF10721.4 EFX00036.1 - 0.015 14.9 4.2 0.045 13.4 2.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2514) KAP_NTPase PF07693.9 EFX00036.1 - 0.018 14.0 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain NACHT PF05729.7 EFX00036.1 - 0.018 14.6 0.1 0.088 12.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.18 EFX00036.1 - 0.019 14.8 0.4 0.056 13.4 0.3 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase PIF1 PF05970.9 EFX00036.1 - 0.027 13.4 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase Bac_DnaA PF00308.13 EFX00036.1 - 0.032 13.8 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein ABC_tran PF00005.22 EFX00036.1 - 0.044 14.0 0.6 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.17 EFX00036.1 - 0.046 13.8 0.0 0.096 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DAP3 PF10236.4 EFX00036.1 - 0.068 12.1 0.0 0.2 10.5 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Sigma54_activat PF00158.21 EFX00036.1 - 0.078 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.1 EFX00036.1 - 0.086 13.1 0.2 0.63 10.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain Metallophos PF00149.23 EFX00037.1 - 7.3e-10 38.5 3.9 2.2e-09 36.9 2.7 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase IPP-2 PF04979.9 EFX00038.1 - 1.6e-12 47.8 2.7 1.6e-12 47.8 1.9 1.7 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Syntaxin PF00804.20 EFX00040.1 - 0.023 14.8 2.0 0.52 10.5 0.4 2.9 2 1 1 3 3 3 0 Syntaxin NPV_P10 PF05531.7 EFX00040.1 - 0.026 14.7 1.6 1.9 8.7 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Transcrip_act PF04949.8 EFX00040.1 - 0.036 13.7 0.4 0.21 11.2 0.0 2.3 2 0 0 2 2 2 0 Transcriptional activator Ndc1_Nup PF09531.5 EFX00040.1 - 0.082 11.3 0.0 0.14 10.5 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HAUS-augmin3 PF14932.1 EFX00040.1 - 0.13 11.4 1.7 0.22 10.6 1.2 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ApoLp-III PF07464.6 EFX00040.1 - 0.15 12.0 2.0 0.38 10.7 0.5 2.4 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF1664 PF07889.7 EFX00040.1 - 6.2 6.6 6.9 61 3.4 0.2 3.5 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) 2-Hacid_dh_C PF02826.14 EFX00041.1 - 1.2e-38 132.0 0.0 1.7e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TAFII28 PF04719.9 EFX00041.1 - 9.8e-10 38.1 0.0 1.8e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region 2-Hacid_dh PF00389.25 EFX00041.1 - 6.7e-09 35.3 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFX00041.1 - 1.1e-07 31.8 0.0 2.5e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.10 EFX00041.1 - 0.055 13.6 0.0 0.18 12.0 0.0 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain DUF2361 PF10153.4 EFX00043.1 - 1.1e-30 106.0 8.0 1.1e-30 106.0 5.5 2.5 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2361) BUD22 PF09073.5 EFX00044.1 - 0.29 10.1 11.1 0.48 9.4 7.7 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.9 EFX00044.1 - 6 4.7 9.2 0.75 7.7 2.0 2.0 2 0 0 2 2 2 0 CDC45-like protein HET PF06985.6 EFX00045.1 - 3e-14 53.3 0.0 6.6e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TPR_19 PF14559.1 EFX00046.1 - 0.002 18.3 3.4 0.017 15.4 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat C1_1 PF00130.17 EFX00047.1 - 0.37 10.5 8.3 0.78 9.5 5.8 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ketoacyl-synt PF00109.21 EFX00048.1 - 1.1e-57 195.3 14.3 2.6e-57 194.2 5.6 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFX00048.1 - 7.4e-37 125.8 1.4 1.6e-36 124.7 1.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Ubiq_cyt_C_chap PF03981.7 EFX00048.1 - 2.9e-35 121.1 0.5 6.9e-35 119.9 0.4 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Thiolase_N PF00108.18 EFX00048.1 - 1.2e-05 24.3 0.4 2.6e-05 23.3 0.3 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFX00048.1 - 0.031 13.7 0.1 0.031 13.7 0.1 3.4 3 1 1 4 4 4 0 Thiolase, C-terminal domain Dus PF01207.12 EFX00049.1 - 4.1e-57 193.3 0.0 6.4e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Glyco_hydro_3 PF00933.16 EFX00050.1 - 2.3e-80 269.7 0.0 3.3e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX00050.1 - 3.6e-47 160.7 0.0 5.1e-46 157.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX00050.1 - 3.1e-23 81.5 0.1 5.4e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Peptidase_C2 PF00648.16 EFX00051.1 - 4.4e-24 85.0 0.0 7.2e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 EFX00051.1 - 2.9e-10 39.9 0.0 0.0011 18.5 0.0 3.3 3 0 0 3 3 3 2 Calpain large subunit, domain III MIT PF04212.13 EFX00051.1 - 0.0018 18.0 0.1 0.0041 16.9 0.1 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain ORC6 PF05460.8 EFX00053.1 - 0.0095 15.0 6.3 0.013 14.5 4.3 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Med19 PF10278.4 EFX00053.1 - 9.6 5.8 11.1 15 5.1 7.7 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 4HBT_2 PF13279.1 EFX00054.1 - 1e-17 64.6 0.1 1.6e-17 64.0 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 EFX00054.1 - 0.06 13.4 0.1 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 Thioesterase superfamily Ribosomal_L28e PF01778.12 EFX00056.1 - 3e-29 101.7 1.6 4.1e-29 101.3 0.0 2.0 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.9 EFX00056.1 - 1.6e-26 92.3 3.1 1.6e-26 92.3 2.2 2.4 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.5 EFX00056.1 - 0.00012 21.2 11.0 0.00015 20.9 7.6 1.2 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.7 EFX00056.1 - 0.0012 16.9 20.9 0.0016 16.4 14.5 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.7 EFX00056.1 - 0.035 13.3 19.0 0.052 12.8 13.2 1.2 1 0 0 1 1 1 0 SDA1 CENP-T PF15511.1 EFX00056.1 - 0.056 12.6 9.0 0.073 12.3 6.3 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T RNase_H2-Ydr279 PF09468.5 EFX00056.1 - 0.2 10.8 2.8 0.38 9.9 2.0 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) CDC45 PF02724.9 EFX00056.1 - 0.24 9.3 11.1 0.37 8.7 7.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Na_trans_assoc PF06512.8 EFX00056.1 - 0.31 10.9 7.0 0.51 10.2 4.9 1.4 1 0 0 1 1 1 0 Sodium ion transport-associated Pox_RNA_Pol_19 PF05320.7 EFX00056.1 - 0.48 10.1 7.1 0.97 9.1 4.9 1.5 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF2890 PF11081.3 EFX00056.1 - 1.8 8.6 10.6 0.11 12.5 3.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) TFIIF_alpha PF05793.7 EFX00056.1 - 2 6.7 23.4 3.3 5.9 16.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sigma70_ner PF04546.8 EFX00056.1 - 2.8 7.5 15.3 1.6 8.3 8.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Tom37_C PF11801.3 EFX00056.1 - 5.3 6.8 6.9 0.59 9.9 0.7 2.2 2 1 0 2 2 2 0 Tom37 C-terminal domain K_trans PF02705.11 EFX00057.1 - 9.9e-175 581.9 16.6 1.2e-174 581.6 11.5 1.0 1 0 0 1 1 1 1 K+ potassium transporter UPF0020 PF01170.13 EFX00058.1 - 2.9e-09 36.7 0.2 2.8e-07 30.2 0.1 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 EFX00058.1 - 1.1e-07 31.8 0.0 2.8e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ldh_1_N PF00056.18 EFX00059.1 - 8.4e-43 145.5 0.4 1.2e-42 145.1 0.3 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 EFX00059.1 - 1.3e-42 145.5 0.0 1.8e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 EFX00059.1 - 0.00036 19.3 0.0 0.00051 18.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ketoacyl-synt PF00109.21 EFX00060.1 - 1.8e-73 247.1 0.1 4e-73 246.0 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX00060.1 - 1.6e-67 228.1 1.1 2.9e-67 227.2 0.8 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EFX00060.1 - 2.4e-67 226.1 3.0 2.4e-67 226.1 2.1 2.2 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 EFX00060.1 - 5.7e-54 182.5 2.5 5.7e-54 182.5 1.7 3.2 3 0 0 3 3 3 1 short chain dehydrogenase PS-DH PF14765.1 EFX00060.1 - 9.8e-52 175.9 6.0 2.4e-51 174.6 4.1 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 EFX00060.1 - 1.5e-40 137.7 0.0 4.7e-40 136.1 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.21 EFX00060.1 - 2.6e-23 81.9 0.1 1.9e-22 79.2 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX00060.1 - 1.4e-13 51.8 0.0 8.4e-13 49.3 0.0 2.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 EFX00060.1 - 2.3e-08 34.1 0.1 7.3e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.7 EFX00060.1 - 3.7e-07 29.8 0.2 1e-06 28.4 0.2 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ACP_syn_III PF08545.5 EFX00060.1 - 0.0019 17.8 0.4 0.019 14.6 0.1 2.8 2 1 0 2 2 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.18 EFX00060.1 - 0.0056 15.6 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain AlaDh_PNT_C PF01262.16 EFX00060.1 - 0.046 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Polysacc_synt_2 PF02719.10 EFX00060.1 - 0.15 10.9 0.0 0.28 10.0 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.8 EFX00060.1 - 0.2 10.9 1.5 0.2 10.9 0.1 1.7 2 0 0 2 2 2 0 NmrA-like family BMF PF15185.1 EFX00061.1 - 5.7 6.1 8.1 8 5.6 5.6 1.2 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis Rifin_STEVOR PF02009.11 EFX00063.1 - 0.0011 18.7 0.5 0.0015 18.2 0.3 1.2 1 0 0 1 1 1 1 Rifin/stevor family TMEM154 PF15102.1 EFX00063.1 - 0.025 14.3 3.9 0.07 12.8 2.7 1.8 1 1 0 1 1 1 0 TMEM154 protein family DUF1675 PF07897.6 EFX00063.1 - 1.8 8.3 11.4 3.4 7.4 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Macoilin PF09726.4 EFX00063.1 - 2.2 6.4 15.5 2.9 6.0 10.7 1.1 1 0 0 1 1 1 0 Transmembrane protein FMN_dh PF01070.13 EFX00064.1 - 3.4e-117 391.2 0.0 4.7e-117 390.8 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EFX00064.1 - 1.5e-20 72.7 0.0 2.8e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EFX00064.1 - 4.7e-08 32.3 0.0 7.8e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 EFX00064.1 - 8.7e-05 21.5 5.3 0.00077 18.4 1.4 2.8 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 EFX00064.1 - 0.00042 19.4 0.1 1.1 8.3 0.0 2.7 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 EFX00064.1 - 0.00085 18.6 0.3 1.2 8.3 0.0 2.7 3 0 0 3 3 3 2 Histidine biosynthesis protein Dus PF01207.12 EFX00064.1 - 0.0013 17.6 0.0 0.018 13.8 0.0 2.2 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 EFX00064.1 - 0.0078 15.2 0.1 0.06 12.2 0.0 2.0 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase NMO PF03060.10 EFX00064.1 - 0.12 11.4 1.0 0.14 11.3 0.1 1.5 2 0 0 2 2 2 0 Nitronate monooxygenase APG17 PF04108.7 EFX00065.1 - 2.6e-93 313.0 0.0 3.1e-93 312.8 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 VIT1 PF01988.14 EFX00065.1 - 2.1e-31 109.1 0.0 5.4e-31 107.7 0.0 1.8 1 0 0 1 1 1 1 VIT family Shadoo PF14999.1 EFX00065.1 - 0.21 11.4 13.3 0.043 13.6 2.5 3.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF4451 PF14616.1 EFX00066.1 - 5.1e-24 84.4 0.1 5.1e-24 84.4 0.1 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4451) EF-hand_6 PF13405.1 EFX00067.1 - 6.8e-11 41.1 0.1 0.00032 20.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 EFX00067.1 - 3.7e-10 38.3 0.5 9.4e-05 21.4 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 EFX00067.1 - 6e-09 35.9 0.6 2.8e-07 30.5 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EFX00067.1 - 1.6e-06 27.1 2.1 0.029 13.6 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 EFX00067.1 - 6.1e-06 25.7 0.0 0.053 13.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 EFX00067.1 - 0.025 14.4 0.0 3.7 7.5 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Mgm101p PF06420.7 EFX00068.1 - 1.4e-89 297.8 0.0 1.8e-89 297.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Pkinase PF00069.20 EFX00069.1 - 2.6e-17 62.8 0.0 4.3e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.11 EFX00070.1 - 2.6e-23 82.3 12.7 2.6e-23 82.3 8.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Histone_HNS PF00816.16 EFX00071.1 - 0.082 13.4 1.4 0.082 13.4 0.1 1.7 1 1 1 2 2 2 0 H-NS histone family MAGE_N PF12440.3 EFX00071.1 - 0.77 10.0 5.6 1.1 9.6 3.9 1.3 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Thiolase_N PF00108.18 EFX00072.1 - 1.1e-65 221.2 2.1 2.8e-65 219.9 1.5 1.6 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFX00072.1 - 1.5e-41 140.6 0.4 3.8e-40 136.1 0.0 2.3 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFX00072.1 - 0.0088 15.5 5.2 0.012 15.1 2.1 2.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EFX00072.1 - 0.077 12.6 1.5 2.4 7.8 0.3 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III WW PF00397.21 EFX00073.1 - 8.1e-05 22.4 2.9 0.00018 21.2 2.0 1.6 1 0 0 1 1 1 1 WW domain 2OG-FeII_Oxy PF03171.15 EFX00074.1 - 6.6e-08 32.7 0.0 2.8e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EFX00074.1 - 0.059 13.9 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal NAD_kinase PF01513.16 EFX00075.1 - 5.1e-49 166.5 0.1 1e-31 109.7 0.0 2.1 2 0 0 2 2 2 2 ATP-NAD kinase YbjM PF11045.3 EFX00075.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative inner membrane protein of Enterobacteriaceae YjbE PF11106.3 EFX00075.1 - 6.6 6.7 12.8 3.3 7.7 5.3 2.6 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE bZIP_2 PF07716.10 EFX00076.1 - 0.00067 19.4 10.9 0.00067 19.4 7.5 2.6 2 0 0 2 2 2 1 Basic region leucine zipper AAA_23 PF13476.1 EFX00076.1 - 0.7 10.1 6.3 1.1 9.5 4.4 1.2 1 0 0 1 1 1 0 AAA domain Zip PF02535.17 EFX00076.1 - 2.4 7.1 12.6 0.73 8.7 0.2 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter TB2_DP1_HVA22 PF03134.14 EFX00077.1 - 1.2e-28 98.6 7.1 1.8e-28 98.1 4.9 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Methyltransf_6 PF03737.10 EFX00078.1 - 1e-27 96.9 0.3 8.3e-27 93.9 0.2 2.0 1 1 0 1 1 1 1 Demethylmenaquinone methyltransferase ICMT PF04140.9 EFX00079.1 - 3.5e-27 94.4 1.0 3.5e-27 94.4 0.7 1.8 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 EFX00079.1 - 1.4e-13 50.8 0.4 1.4e-13 50.8 0.3 2.4 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 EFX00079.1 - 0.00039 19.7 0.5 0.00072 18.9 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF973 PF06157.6 EFX00079.1 - 0.15 10.9 0.2 0.25 10.2 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF973) TauD PF02668.11 EFX00080.1 - 1.3e-18 67.6 0.1 4.1e-18 65.9 0.1 1.7 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family BPL_N PF09825.4 EFX00081.1 - 2.3e-117 391.9 0.0 3.4e-117 391.3 0.0 1.2 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.14 EFX00081.1 - 6.2e-14 52.0 0.0 1.2e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family NUDE_C PF04880.8 EFX00082.1 - 5.9e-17 62.5 2.4 5.9e-17 62.5 1.6 4.4 1 1 2 4 4 4 1 NUDE protein, C-terminal conserved region IncA PF04156.9 EFX00082.1 - 7.5e-05 22.4 28.3 0.0066 16.0 11.9 2.6 2 1 1 3 3 3 2 IncA protein DUF904 PF06005.7 EFX00082.1 - 0.0025 18.0 6.4 0.0025 18.0 4.5 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF904) TPR_MLP1_2 PF07926.7 EFX00082.1 - 0.11 12.2 27.3 0.11 12.2 9.6 2.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein EF1G PF00647.14 EFX00082.1 - 0.6 9.8 1.8 0.52 10.0 0.1 1.6 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain Chibby PF14645.1 EFX00082.1 - 0.67 9.8 10.0 2.6 7.9 0.7 2.6 1 1 1 2 2 2 0 Chibby family DUF745 PF05335.8 EFX00082.1 - 1.1 8.7 7.7 2 7.8 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) GFA PF04828.9 EFX00083.1 - 0.051 13.5 0.0 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-ribbon_3 PF13248.1 EFX00083.1 - 0.056 12.6 1.5 0.072 12.3 0.3 1.7 2 0 0 2 2 2 0 zinc-ribbon domain Flavoprotein PF02441.14 EFX00084.1 - 5.1e-37 126.4 0.3 7.5e-37 125.8 0.2 1.3 1 0 0 1 1 1 1 Flavoprotein AAA_2 PF07724.9 EFX00085.1 - 3.9e-46 157.0 0.0 3.2e-45 154.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 EFX00085.1 - 2.7e-25 89.0 0.0 7.4e-13 48.8 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 EFX00085.1 - 1.1e-23 82.9 1.8 1.5e-23 82.5 0.2 2.1 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 EFX00085.1 - 2.6e-13 49.8 0.4 7e-10 38.7 0.0 3.7 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFX00085.1 - 7.8e-12 45.4 0.1 2e-05 24.7 0.0 4.5 3 1 1 4 4 4 2 AAA domain AAA_16 PF13191.1 EFX00085.1 - 6.5e-10 39.2 6.9 9e-06 25.7 0.0 5.7 3 2 4 7 7 7 1 AAA ATPase domain Clp_N PF02861.15 EFX00085.1 - 1.1e-07 31.6 0.1 0.0047 16.8 0.0 3.8 3 0 0 3 3 3 2 Clp amino terminal domain AAA_17 PF13207.1 EFX00085.1 - 1.4e-07 32.3 1.9 0.01 16.6 0.0 3.6 2 2 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 EFX00085.1 - 9.7e-07 28.4 0.0 1.1e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.1 EFX00085.1 - 6e-06 26.5 0.1 0.22 11.8 0.0 3.8 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.1 EFX00085.1 - 0.00016 21.3 1.6 0.13 12.0 0.0 3.6 3 0 0 3 3 3 1 Part of AAA domain AAA_3 PF07726.6 EFX00085.1 - 0.0003 20.3 0.0 0.51 9.9 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 EFX00085.1 - 0.00034 19.6 0.0 0.0011 17.9 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.12 EFX00085.1 - 0.0011 18.4 0.0 0.013 14.9 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.1 EFX00085.1 - 0.0011 18.8 0.0 0.21 11.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EFX00085.1 - 0.0011 18.6 0.0 0.45 10.2 0.0 2.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 EFX00085.1 - 0.0014 18.6 0.0 0.7 9.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EFX00085.1 - 0.0021 17.2 0.8 0.16 11.1 0.0 3.1 3 1 0 4 4 4 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EFX00085.1 - 0.0038 17.3 0.0 0.46 10.6 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Zeta_toxin PF06414.7 EFX00085.1 - 0.0038 16.3 0.2 0.021 13.9 0.0 2.4 4 0 0 4 4 3 1 Zeta toxin AAA_10 PF12846.2 EFX00085.1 - 0.0049 16.3 1.1 0.45 9.9 0.0 3.6 4 1 1 5 5 4 1 AAA-like domain Torsin PF06309.6 EFX00085.1 - 0.0066 16.3 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Torsin Macoilin PF09726.4 EFX00085.1 - 0.014 13.6 7.0 0.026 12.8 4.9 1.3 1 0 0 1 1 1 0 Transmembrane protein ResIII PF04851.10 EFX00085.1 - 0.019 14.7 0.0 0.35 10.6 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_25 PF13481.1 EFX00085.1 - 0.024 14.0 1.7 1.7 7.9 0.0 4.0 4 1 0 5 5 5 0 AAA domain ABC_tran PF00005.22 EFX00085.1 - 0.041 14.1 0.5 0.65 10.2 0.0 3.1 4 0 0 4 4 4 0 ABC transporter Snapin_Pallidin PF14712.1 EFX00085.1 - 0.15 12.4 4.2 4 7.8 0.9 2.9 2 0 0 2 2 2 0 Snapin/Pallidin AAA_23 PF13476.1 EFX00085.1 - 2.1 8.5 0.0 2.1 8.5 0.0 3.1 3 1 0 3 3 1 0 AAA domain DUF607 PF04678.8 EFX00085.1 - 3.6 7.4 6.7 9.8 6.0 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function, DUF607 Cortex-I_coil PF09304.5 EFX00085.1 - 4 7.5 16.7 0.15 12.1 6.1 2.7 3 0 0 3 3 2 0 Cortexillin I, coiled coil ABC_tran PF00005.22 EFX00086.1 - 2.5e-46 157.3 0.0 8e-27 94.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFX00086.1 - 2e-29 102.9 41.1 2.6e-18 66.4 9.6 3.4 3 1 0 3 3 2 2 ABC transporter transmembrane region SMC_N PF02463.14 EFX00086.1 - 3.6e-11 42.7 2.9 2.6e-05 23.5 0.0 4.1 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 EFX00086.1 - 2.2e-09 37.0 0.1 0.00033 20.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.1 EFX00086.1 - 3.5e-07 30.4 0.0 3.6 7.4 0.0 4.6 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.1 EFX00086.1 - 9e-06 25.8 0.4 0.059 13.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX00086.1 - 2.5e-05 23.7 3.3 0.00058 19.3 0.2 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFX00086.1 - 4.2e-05 23.6 0.1 0.18 11.7 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain T2SE PF00437.15 EFX00086.1 - 7.1e-05 21.8 0.8 0.038 12.8 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein DUF2075 PF09848.4 EFX00086.1 - 0.00017 20.7 0.3 0.11 11.4 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 EFX00086.1 - 0.0013 18.4 7.4 0.51 10.1 0.1 4.0 4 0 0 4 4 3 2 Part of AAA domain Arch_ATPase PF01637.13 EFX00086.1 - 0.0014 18.3 0.0 0.079 12.6 0.0 2.6 2 1 0 2 2 2 1 Archaeal ATPase NACHT PF05729.7 EFX00086.1 - 0.0014 18.3 0.5 1.8 8.1 0.0 2.6 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.17 EFX00086.1 - 0.0018 18.3 0.0 0.36 11.0 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Miro PF08477.8 EFX00086.1 - 0.0024 18.3 0.0 0.75 10.3 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein FtsK_SpoIIIE PF01580.13 EFX00086.1 - 0.0031 17.0 0.2 0.42 10.0 0.0 2.9 3 0 0 3 3 3 1 FtsK/SpoIIIE family Dynamin_N PF00350.18 EFX00086.1 - 0.0039 17.0 0.2 1.2 8.9 0.1 2.4 2 0 0 2 2 2 1 Dynamin family AAA_23 PF13476.1 EFX00086.1 - 0.0047 17.2 3.8 0.87 9.8 0.3 2.3 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFX00086.1 - 0.0067 15.6 0.2 3.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EFX00086.1 - 0.013 15.4 0.0 0.74 9.7 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase SbcCD_C PF13558.1 EFX00086.1 - 0.014 15.2 0.1 2.6 8.0 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit cobW PF02492.14 EFX00086.1 - 0.018 14.4 3.3 0.74 9.2 0.1 2.6 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain KaiC PF06745.8 EFX00086.1 - 0.019 14.0 1.7 0.15 11.1 0.0 2.5 3 0 0 3 3 3 0 KaiC AAA_18 PF13238.1 EFX00086.1 - 0.024 14.9 0.4 0.22 11.7 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 EFX00086.1 - 0.028 14.6 0.2 6.6 6.9 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFX00086.1 - 0.05 13.0 0.0 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain 2Fe-2S_thioredx PF01257.14 EFX00086.1 - 0.09 12.3 0.0 2.1 7.9 0.0 2.5 3 0 0 3 3 2 0 Thioredoxin-like [2Fe-2S] ferredoxin PhoH PF02562.11 EFX00086.1 - 0.1 11.8 1.0 12 5.0 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.1 EFX00086.1 - 0.12 11.9 0.0 0.38 10.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_10 PF12846.2 EFX00086.1 - 0.19 11.1 6.9 0.58 9.5 0.1 2.9 4 0 0 4 4 3 0 AAA-like domain MobB PF03205.9 EFX00086.1 - 0.2 11.3 0.5 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TIP49 PF06068.8 EFX00086.1 - 0.21 10.2 0.5 14 4.2 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus DUF87 PF01935.12 EFX00086.1 - 0.26 11.0 3.5 0.32 10.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_17 PF13207.1 EFX00086.1 - 0.27 12.0 3.3 0.25 12.1 0.1 2.6 3 0 0 3 3 1 0 AAA domain UPF0079 PF02367.12 EFX00086.1 - 0.28 10.8 1.2 8 6.1 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_13 PF13166.1 EFX00086.1 - 0.4 9.0 0.4 6.6 5.0 0.0 2.4 3 0 0 3 3 3 0 AAA domain Pox_A32 PF04665.7 EFX00086.1 - 0.55 9.4 1.1 9.6 5.4 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_30 PF13604.1 EFX00086.1 - 0.8 9.2 2.5 20 4.7 0.0 3.2 4 0 0 4 4 3 0 AAA domain AAA_24 PF13479.1 EFX00086.1 - 1.4 8.4 3.3 13 5.3 0.3 2.4 2 0 0 2 2 2 0 AAA domain ILVD_EDD PF00920.16 EFX00087.1 - 8.4e-206 684.4 0.0 9.8e-206 684.1 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family WD40 PF00400.27 EFX00089.1 - 1.4e-69 227.6 12.3 1.4e-10 40.6 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.5 EFX00089.1 - 7.1e-26 90.2 8.7 1.1e-25 89.6 6.1 1.3 1 0 0 1 1 1 1 Tup N-terminal Nup160 PF11715.3 EFX00089.1 - 0.00085 17.5 0.2 0.51 8.4 0.0 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFX00089.1 - 0.0056 15.4 0.1 0.39 9.4 0.1 3.0 1 1 0 2 2 2 1 Nup133 N terminal like Cytochrom_D1 PF02239.11 EFX00089.1 - 0.016 13.5 0.6 0.21 9.8 0.1 2.5 1 1 1 2 2 2 0 Cytochrome D1 heme domain Nbas_N PF15492.1 EFX00089.1 - 0.029 13.4 0.1 16 4.4 0.0 3.0 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal GTP_EFTU PF00009.22 EFX00090.1 - 1.6e-44 151.6 0.4 2.8e-44 150.8 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFX00090.1 - 4.2e-21 74.9 0.0 9.4e-21 73.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFX00090.1 - 7.3e-07 29.2 2.4 9.2e-07 28.8 0.4 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX00090.1 - 1.9e-05 24.6 0.0 5e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Med15 PF09606.5 EFX00090.1 - 6.2 4.8 24.8 9.1 4.3 17.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Methyltransf_18 PF12847.2 EFX00091.1 - 2.9e-11 43.9 0.2 7.9e-11 42.5 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00091.1 - 1.4e-09 37.6 0.0 2e-08 33.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX00091.1 - 6.8e-08 32.5 2.7 1.9e-07 31.1 0.3 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00091.1 - 3.1e-06 27.5 0.1 1.1e-05 25.8 0.1 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX00091.1 - 1.4e-05 24.9 0.0 4.1e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00091.1 - 3.4e-05 24.2 0.0 0.00014 22.3 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain HEAT PF02985.17 EFX00091.1 - 0.0031 17.4 11.1 0.48 10.6 0.0 6.2 7 0 0 7 7 6 1 HEAT repeat Methyltransf_25 PF13649.1 EFX00091.1 - 0.015 15.6 0.0 0.051 13.9 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 EFX00091.1 - 0.018 14.7 0.1 0.068 12.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.7 EFX00091.1 - 0.026 13.9 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW HEAT_EZ PF13513.1 EFX00091.1 - 0.16 12.5 0.0 0.16 12.5 0.0 6.8 8 1 1 9 9 8 0 HEAT-like repeat Hid1 PF12722.2 EFX00091.1 - 4 5.0 1.7 7.7 4.0 1.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rtf2 PF04641.7 EFX00092.1 - 2.1e-45 154.9 0.1 2.6e-45 154.6 0.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_UBOX PF13445.1 EFX00092.1 - 0.00025 20.6 0.1 0.00065 19.3 0.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 EFX00092.1 - 0.00035 20.3 0.7 0.00062 19.5 0.1 1.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 EFX00092.1 - 0.00094 18.8 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain SelP_N PF04592.9 EFX00092.1 - 0.0022 17.4 0.7 0.0034 16.8 0.5 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region zf-C3HC4_2 PF13923.1 EFX00092.1 - 0.015 15.3 0.3 0.033 14.1 0.1 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX00092.1 - 0.055 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 EFX00092.1 - 0.12 11.8 0.1 0.26 10.8 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit UPF0547 PF10571.4 EFX00092.1 - 0.44 10.2 2.5 12 5.6 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Vfa1 PF08432.5 EFX00092.1 - 0.77 9.7 6.9 1.2 9.1 4.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SAPS PF04499.10 EFX00092.1 - 0.97 7.9 4.0 1.3 7.6 2.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TIP41 PF04176.8 EFX00093.1 - 1.2e-65 220.1 0.0 1.7e-65 219.7 0.0 1.2 1 0 0 1 1 1 1 TIP41-like family AA_permease PF00324.16 EFX00094.1 - 5.3e-124 414.1 40.7 6.6e-124 413.8 28.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX00094.1 - 1.9e-30 105.7 43.6 2.7e-30 105.2 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease TPP_enzyme_N PF02776.13 EFX00095.1 - 6.5e-37 126.6 0.0 8.1e-36 123.0 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFX00095.1 - 8.2e-21 74.2 0.0 1.9e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 EFX00095.1 - 2.4e-19 69.3 0.0 5.8e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fungal_lectin PF07938.7 EFX00095.1 - 5.5e-12 45.5 1.5 3.7e-05 23.1 0.0 2.3 1 1 1 2 2 2 2 Fungal fucose-specific lectin Gal-bind_lectin PF00337.17 EFX00095.1 - 1.6e-05 24.2 0.0 3.1e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Galactoside-binding lectin DUF2183 PF09949.4 EFX00096.1 - 4.7e-29 100.2 0.0 8.2e-29 99.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) SR-25 PF10500.4 EFX00096.1 - 2.9 7.3 5.5 4.4 6.7 3.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Abhydrolase_3 PF07859.8 EFX00097.1 - 4.7e-25 88.4 0.1 8.2e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 EFX00097.1 - 3.1e-14 52.3 0.0 4e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 EFX00097.1 - 0.00051 19.8 0.2 0.00093 18.9 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX00097.1 - 0.0042 16.3 0.1 0.011 14.9 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Mito_carr PF00153.22 EFX00099.1 - 5.4e-15 54.8 6.2 6.8e-11 41.7 0.1 4.1 4 1 0 4 4 4 2 Mitochondrial carrier protein NTR2 PF15458.1 EFX00099.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Nineteen complex-related protein 2 CPSF_A PF03178.10 EFX00100.1 - 8.2e-95 317.5 0.0 3.7e-94 315.4 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.4 EFX00100.1 - 7.9e-63 212.3 0.0 1.1e-62 211.8 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term WD40 PF00400.27 EFX00100.1 - 0.035 13.9 0.1 0.12 12.2 0.1 2.0 1 0 0 1 1 1 0 WD domain, G-beta repeat Thymidylate_kin PF02223.12 EFX00101.1 - 0.011 15.0 0.0 0.031 13.6 0.0 1.7 1 0 0 1 1 1 0 Thymidylate kinase PUF PF00806.14 EFX00102.1 - 1.7e-28 96.4 0.0 0.00014 21.1 0.0 5.8 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.17 EFX00102.1 - 1.2e-12 47.2 0.0 2.3e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX00102.1 - 1.2e-05 25.0 0.0 2.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX00102.1 - 2.2e-05 24.3 0.0 6.4e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Suf PF05843.9 EFX00102.1 - 0.11 12.1 6.5 0.2 11.3 4.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Zip PF02535.17 EFX00102.1 - 0.2 10.6 5.6 0.33 9.9 3.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.2 EFX00102.1 - 0.51 7.9 3.6 0.72 7.4 2.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.4 EFX00102.1 - 3.8 5.6 21.2 6.5 4.8 14.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Trypan_PARP PF05887.6 EFX00103.1 - 0.0026 17.5 25.0 0.0026 17.5 17.4 14.4 7 3 8 15 15 15 3 Procyclic acidic repetitive protein (PARP) DUF500 PF04366.7 EFX00105.1 - 2.8e-37 126.9 0.0 4.5e-37 126.2 0.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF500) Aldedh PF00171.17 EFX00106.1 - 2.7e-182 606.2 0.1 3.1e-182 606.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BAR PF03114.13 EFX00107.1 - 3e-61 206.8 4.5 3.7e-61 206.5 3.1 1.1 1 0 0 1 1 1 1 BAR domain HrpB2 PF09487.5 EFX00107.1 - 0.2 11.8 1.3 0.32 11.1 0.2 1.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) BAR_2 PF10455.4 EFX00107.1 - 0.33 9.8 3.9 1.4 7.7 2.7 2.0 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking DnaJ PF00226.26 EFX00107.1 - 0.34 10.6 3.3 1.7 8.4 0.8 2.7 2 1 0 2 2 2 0 DnaJ domain HisKA_3 PF07730.8 EFX00107.1 - 5.7 7.3 6.5 11 6.4 0.3 3.0 3 0 0 3 3 3 0 Histidine kinase Bac_luciferase PF00296.15 EFX00108.1 - 5e-60 203.2 10.0 7.2e-60 202.6 7.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase Whi5 PF08528.6 EFX00111.1 - 5.7e-09 35.3 0.1 9.9e-09 34.5 0.0 1.4 1 0 0 1 1 1 1 Whi5 like Aldedh PF00171.17 EFX00112.1 - 3.2e-134 447.7 0.0 3.9e-128 427.6 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.6 EFX00112.1 - 0.00046 19.4 0.0 0.00091 18.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) PNRC PF15365.1 EFX00113.1 - 5.4e-07 29.5 4.1 5.4e-07 29.5 2.9 3.9 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator DUF3535 PF12054.3 EFX00115.1 - 6.8e-141 469.8 1.7 1.1e-139 465.8 0.7 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 EFX00115.1 - 4.1e-72 242.4 0.0 6.2e-72 241.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 EFX00115.1 - 5.4e-17 60.2 5.6 0.0054 16.7 0.0 8.6 8 0 0 8 8 8 5 HEAT repeat Helicase_C PF00271.26 EFX00115.1 - 8.6e-15 54.3 0.0 1.8e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_EZ PF13513.1 EFX00115.1 - 1.6e-08 34.8 7.6 6.8 7.3 0.0 9.3 9 0 0 9 9 9 3 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFX00115.1 - 2e-08 34.5 0.2 0.22 11.9 0.0 4.1 4 0 0 4 4 4 3 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.1 EFX00115.1 - 2e-07 31.1 15.1 0.0035 17.5 0.0 8.1 7 2 2 9 9 9 2 HEAT repeats CLASP_N PF12348.3 EFX00115.1 - 0.0012 18.1 0.1 1.9 7.8 0.0 3.0 3 0 0 3 3 3 2 CLASP N terminal Cnd1 PF12717.2 EFX00115.1 - 0.012 15.4 0.4 0.37 10.6 0.0 3.5 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Iso_dh PF00180.15 EFX00116.1 - 4.3e-123 410.6 0.0 5.7e-123 410.2 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PHD PF00628.24 EFX00116.1 - 3.3e-08 33.1 3.9 5.2e-08 32.4 2.7 1.3 1 0 0 1 1 1 1 PHD-finger DUF745 PF05335.8 EFX00116.1 - 0.25 10.8 2.7 0.5 9.8 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) PHD_2 PF13831.1 EFX00116.1 - 2 7.8 3.8 3.3 7.0 2.7 1.3 1 0 0 1 1 1 0 PHD-finger Actin PF00022.14 EFX00117.1 - 3.9e-25 88.0 0.0 8.9e-15 53.9 0.0 3.1 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.8 EFX00117.1 - 0.0027 16.3 0.0 0.022 13.3 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Erf4 PF10256.4 EFX00119.1 - 0.0014 18.4 0.0 0.004 16.9 0.0 1.7 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family LicD PF04991.8 EFX00119.1 - 0.067 13.2 0.2 0.093 12.8 0.1 1.1 1 0 0 1 1 1 0 LicD family BLVR PF06375.6 EFX00119.1 - 0.43 10.4 8.4 0.4 10.4 4.8 1.7 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) Peptidase_S49_N PF08496.5 EFX00119.1 - 4 7.2 6.7 7.2 6.3 4.7 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SET PF00856.23 EFX00120.1 - 2.8e-18 66.7 0.1 1.8e-17 64.1 0.0 2.4 2 1 0 2 2 2 1 SET domain ubiquitin PF00240.18 EFX00120.1 - 1.7e-05 24.1 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Pre-SET PF05033.11 EFX00120.1 - 0.00015 21.9 0.5 0.00026 21.2 0.3 1.4 1 0 0 1 1 1 1 Pre-SET motif DUF2407 PF10302.4 EFX00120.1 - 0.0016 18.6 0.0 0.0057 16.8 0.0 1.9 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.3 EFX00120.1 - 0.012 15.2 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Spt5_N PF11942.3 EFX00120.1 - 0.63 10.7 16.5 0.38 11.4 6.4 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.9 EFX00120.1 - 3.6 5.5 14.6 1.7 6.6 6.2 2.2 2 0 0 2 2 2 0 CDC45-like protein DCP1 PF06058.8 EFX00121.1 - 3.7e-10 39.9 0.0 6.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family Peptidase_C97 PF05903.9 EFX00122.1 - 1.9e-06 27.7 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 EFX00122.1 - 0.007 16.3 1.4 0.032 14.1 0.1 2.4 1 1 1 2 2 2 1 Lecithin retinol acyltransferase Pkinase PF00069.20 EFX00123.1 - 7.2e-59 199.0 0.0 1e-58 198.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00123.1 - 1.8e-20 73.0 0.0 3.2e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00123.1 - 2e-05 23.7 0.0 3.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX00123.1 - 0.0002 20.4 0.1 0.00034 19.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX00123.1 - 0.0014 18.3 0.9 0.0054 16.4 0.3 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFX00123.1 - 0.0025 17.1 0.7 0.012 14.9 0.3 2.1 2 1 0 2 2 2 1 RIO1 family PAS_9 PF13426.1 EFX00123.1 - 0.032 14.6 0.0 2.6 8.4 0.0 3.2 4 0 0 4 4 4 0 PAS domain Ank_2 PF12796.2 EFX00124.1 - 1.4e-25 89.4 0.2 4.4e-17 62.1 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX00124.1 - 1.3e-17 62.5 6.0 4.6e-07 29.3 0.4 5.8 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.1 EFX00124.1 - 3.6e-15 55.6 5.7 1.2e-07 31.7 0.2 4.9 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX00124.1 - 2.8e-13 49.9 0.4 0.00012 22.4 0.0 3.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX00124.1 - 5.2e-13 47.8 0.1 0.0007 19.6 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ribosomal_L14 PF00238.14 EFX00126.1 - 4.5e-44 149.1 2.8 5e-44 148.9 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e WD40 PF00400.27 EFX00127.1 - 3.4e-46 153.5 15.0 1.5e-07 30.9 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 EFX00127.1 - 0.039 13.6 0.0 2.1 7.9 0.0 2.5 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 EFX00127.1 - 0.061 12.0 0.0 0.77 8.4 0.0 2.4 2 1 0 2 2 2 0 Nup133 N terminal like MBOAT PF03062.14 EFX00128.1 - 2e-39 135.6 14.3 2e-39 135.6 9.9 3.2 2 1 1 3 3 3 2 MBOAT, membrane-bound O-acyltransferase family Arf PF00025.16 EFX00129.1 - 1.9e-65 219.3 0.0 2.1e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 EFX00129.1 - 3.5e-10 39.1 0.3 1.9e-06 26.8 0.0 2.5 1 1 0 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 EFX00129.1 - 9.6e-08 31.4 0.0 1.2e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EFX00129.1 - 2.5e-07 30.2 0.0 3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX00129.1 - 2.8e-07 31.0 0.0 4.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFX00129.1 - 4.2e-07 29.9 0.0 5.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 EFX00129.1 - 1.3e-05 24.4 0.0 1.5e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EFX00129.1 - 0.004 16.5 0.0 0.2 11.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.14 EFX00129.1 - 0.12 11.8 0.0 8.9 5.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 EFX00129.1 - 0.13 11.7 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation HTH_Tnp_ISL3 PF13542.1 EFX00130.1 - 0.096 11.8 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 tRNA_lig_CPD PF08302.6 EFX00132.1 - 2.5e-77 259.5 0.0 3.6e-77 259.0 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.5 EFX00132.1 - 6.6e-76 254.6 0.0 1.2e-75 253.8 0.0 1.4 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.6 EFX00132.1 - 1.4e-51 174.7 0.0 2.7e-51 173.7 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_33 PF13671.1 EFX00132.1 - 0.036 13.9 1.9 0.073 12.9 0.2 2.4 2 1 0 2 2 2 0 AAA domain SpecificRecomb PF10136.4 EFX00132.1 - 0.082 10.9 0.2 0.12 10.4 0.1 1.2 1 0 0 1 1 1 0 Site-specific recombinase DUF4023 PF13215.1 EFX00132.1 - 1.3 8.8 4.4 3.5 7.4 3.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) Rotamase PF00639.16 EFX00133.1 - 9.9e-23 80.7 0.1 3e-22 79.1 0.0 1.7 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 EFX00133.1 - 9e-16 58.1 0.0 1.2e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 EFX00133.1 - 6.8e-08 32.2 1.7 1.4e-07 31.2 1.2 1.5 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.1 EFX00133.1 - 1.4e-06 28.9 0.0 2.7e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain MAM PF00629.18 EFX00133.1 - 0.0077 16.0 0.2 0.018 14.8 0.1 1.5 1 1 1 2 2 2 1 MAM domain DUF3482 PF11981.3 EFX00133.1 - 3.8 6.6 7.5 2.9 7.0 2.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3482) Amidase PF01425.16 EFX00134.1 - 3.4e-83 279.9 0.0 4.2e-83 279.6 0.0 1.1 1 0 0 1 1 1 1 Amidase PARP PF00644.15 EFX00136.1 - 2.2e-60 203.5 0.0 3.1e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 EFX00136.1 - 2.1e-36 124.5 0.0 3.3e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 EFX00136.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 WGR domain Pkinase PF00069.20 EFX00137.1 - 3.3e-59 200.1 0.0 5.2e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00137.1 - 2.7e-34 118.4 0.0 4.2e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00137.1 - 7.6e-15 54.6 0.0 4.3e-12 45.6 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 EFX00137.1 - 0.1 11.6 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M20 PF01546.23 EFX00138.1 - 3.8e-24 85.2 0.4 5.4e-24 84.7 0.3 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX00138.1 - 1.4e-06 27.9 0.1 3.1e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFX00138.1 - 0.035 13.8 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 DPM2 PF07297.7 EFX00139.1 - 1.1e-34 118.5 2.9 1.3e-34 118.3 2.0 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.7 EFX00139.1 - 7e-06 25.6 0.9 7.8e-06 25.5 0.6 1.1 1 0 0 1 1 1 1 PIG-P DUF4229 PF14012.1 EFX00139.1 - 0.00077 19.3 0.1 0.00077 19.3 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) DUF4083 PF13314.1 EFX00139.1 - 0.0018 18.0 0.3 0.0018 18.0 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4083) COX14 PF14880.1 EFX00139.1 - 0.011 15.3 2.3 0.46 10.1 0.0 2.1 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Cytochrom_C_asm PF01578.15 EFX00139.1 - 0.012 15.1 0.2 0.013 15.0 0.1 1.0 1 0 0 1 1 1 0 Cytochrome C assembly protein DUF1469 PF07332.6 EFX00139.1 - 0.031 13.9 1.0 0.039 13.6 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) TPPK_C PF12555.3 EFX00139.1 - 4.9 6.9 9.0 3.5 7.4 0.7 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal PspC PF04024.7 EFX00139.1 - 5.4 6.5 6.2 16 5.0 0.8 2.2 2 0 0 2 2 2 0 PspC domain HAD_2 PF13419.1 EFX00140.1 - 5.6e-17 62.5 0.0 1.6e-16 61.0 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX00140.1 - 0.0083 15.8 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like SPC12 PF06645.8 EFX00141.1 - 4.7e-26 90.4 0.0 5.6e-26 90.1 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) PTS_2-RNA PF01885.11 EFX00142.1 - 1.5e-51 174.3 0.0 2e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Sec15 PF04091.7 EFX00143.1 - 6e-116 387.1 4.9 6e-116 387.1 3.4 2.1 3 0 0 3 3 3 1 Exocyst complex subunit Sec15-like DUF4201 PF13870.1 EFX00143.1 - 0.0058 16.0 4.4 0.017 14.5 3.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) Mod_r PF07200.8 EFX00143.1 - 0.42 10.5 8.8 0.21 11.4 1.0 3.2 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DAGK_prokar PF01219.14 EFX00143.1 - 0.42 10.2 1.8 25 4.5 0.0 3.1 3 0 0 3 3 3 0 Prokaryotic diacylglycerol kinase AMP-binding PF00501.23 EFX00144.1 - 3.6e-58 196.9 2.4 5.4e-33 114.0 0.0 4.5 2 2 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.6 EFX00144.1 - 2.4e-11 44.2 0.0 7.4e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.7 EFX00144.1 - 0.0082 15.9 0.4 0.023 14.4 0.3 1.7 1 0 0 1 1 1 1 Gas vesicle protein G Transferase PF02458.10 EFX00145.1 - 8.8e-15 54.0 0.0 8.7e-14 50.7 0.0 2.3 1 1 0 1 1 1 1 Transferase family Phosducin PF02114.11 EFX00146.1 - 6.4e-11 41.4 0.1 8e-10 37.8 0.1 2.3 1 1 0 1 1 1 1 Phosducin DUF2847 PF11009.3 EFX00146.1 - 0.038 13.5 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2847) Mhr1 PF12829.2 EFX00148.1 - 2.1e-29 101.1 0.1 3e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination zf-rbx1 PF12678.2 EFX00149.1 - 0.18 11.9 4.5 0.4 10.8 3.1 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_2 PF13639.1 EFX00149.1 - 0.53 10.1 11.5 0.81 9.5 5.5 2.9 2 1 0 2 2 2 0 Ring finger domain Exo_endo_phos PF03372.18 EFX00150.1 - 1.7e-16 60.9 0.8 5e-16 59.4 0.6 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.27 EFX00151.1 - 2.3e-77 252.3 36.1 2.2e-13 49.5 0.1 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat Ank_2 PF12796.2 EFX00151.1 - 1.2e-26 92.8 0.0 1.5e-10 41.2 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX00151.1 - 5.1e-24 82.8 0.1 3.6e-07 29.6 0.0 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 EFX00151.1 - 9.3e-22 76.5 1.4 1.5e-09 37.7 0.0 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX00151.1 - 9e-20 70.6 0.2 7.5e-12 45.4 0.0 4.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX00151.1 - 9.9e-18 62.4 0.1 4.7e-05 23.2 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Nup160 PF11715.3 EFX00151.1 - 5.5e-11 41.3 8.5 0.0071 14.5 0.1 5.4 1 1 4 5 5 5 4 Nucleoporin Nup120/160 NACHT PF05729.7 EFX00151.1 - 7.6e-09 35.4 0.0 1.6e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EFX00151.1 - 6.9e-05 22.9 0.1 0.00025 21.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX00151.1 - 0.00024 21.2 0.0 0.001 19.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain Nucleoporin_N PF08801.6 EFX00151.1 - 0.00061 18.6 5.1 0.094 11.4 0.1 3.8 1 1 0 2 2 2 2 Nup133 N terminal like KAP_NTPase PF07693.9 EFX00151.1 - 0.011 14.7 0.1 2 7.3 0.0 2.3 1 1 1 2 2 2 0 KAP family P-loop domain Cytochrom_D1 PF02239.11 EFX00151.1 - 0.011 14.0 4.7 1.2 7.4 0.2 3.4 1 1 3 4 4 4 0 Cytochrome D1 heme domain Arch_ATPase PF01637.13 EFX00151.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 EFX00151.1 - 0.12 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain His_biosynth PF00977.16 EFX00152.1 - 2.7e-27 95.5 0.0 2.4e-26 92.4 0.0 1.9 1 1 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.12 EFX00152.1 - 0.021 14.1 0.1 0.037 13.2 0.1 1.4 1 0 0 1 1 1 0 PcrB family Ribul_P_3_epim PF00834.14 EFX00152.1 - 0.074 12.1 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Lactamase_B_2 PF12706.2 EFX00153.1 - 1.7e-30 106.0 0.0 3.4e-30 105.0 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 EFX00153.1 - 1.1e-25 88.8 0.0 3.2e-25 87.3 0.0 1.9 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.22 EFX00153.1 - 7.3e-09 35.5 0.0 3.2e-08 33.4 0.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily PUL PF08324.6 EFX00154.1 - 2e-39 135.0 0.0 2.6e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.9 EFX00154.1 - 8.8e-35 119.7 0.0 1.4e-34 119.0 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.15 EFX00154.1 - 1.6e-14 53.3 0.0 3.6e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFX00154.1 - 0.0004 20.5 0.1 0.0019 18.3 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.1 EFX00154.1 - 0.0004 20.1 0.0 0.003 17.3 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain DUF2847 PF11009.3 EFX00154.1 - 0.0084 15.6 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2847) AhpC-TSA PF00578.16 EFX00154.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family TraF PF13728.1 EFX00154.1 - 0.013 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.1 EFX00154.1 - 0.016 15.2 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Redoxin PF08534.5 EFX00154.1 - 0.027 14.0 0.1 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.1 EFX00154.1 - 0.086 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like T4_deiodinase PF00837.12 EFX00154.1 - 0.097 11.6 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Iodothyronine deiodinase EF-hand_1 PF00036.27 EFX00155.1 - 1.4e-22 77.1 3.5 8.3e-07 27.8 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 EFX00155.1 - 6.5e-21 73.7 7.2 9.9e-15 53.9 0.3 3.4 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 EFX00155.1 - 6.5e-20 69.1 1.7 2.1e-06 27.1 0.2 3.6 3 1 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 EFX00155.1 - 7.4e-17 61.2 1.6 1.6e-10 40.9 0.0 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EFX00155.1 - 3.5e-12 45.0 5.1 3.8e-05 22.8 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 EFX00155.1 - 1.2e-10 41.1 0.0 4e-08 33.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 EFX00155.1 - 7.6e-05 22.3 0.0 0.01 15.5 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.8 EFX00155.1 - 0.0067 16.0 0.0 0.42 10.1 0.0 2.2 2 0 0 2 2 2 1 Caleosin related protein FAD_binding_3 PF01494.14 EFX00157.1 - 1.6e-58 198.4 0.0 2e-58 198.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 EFX00157.1 - 1.7e-06 27.7 0.0 3.8e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.19 EFX00157.1 - 1.1e-05 24.5 0.1 5e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX00157.1 - 6.5e-05 22.9 0.0 0.0064 16.4 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX00157.1 - 6.9e-05 22.7 0.1 0.00021 21.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EFX00157.1 - 0.0001 21.4 0.0 0.0002 20.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 EFX00157.1 - 0.0022 16.8 0.0 0.0041 16.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.9 EFX00157.1 - 0.0034 16.0 0.1 0.015 13.9 0.0 1.9 2 0 0 2 2 2 1 Tryptophan halogenase HI0933_like PF03486.9 EFX00157.1 - 0.0035 15.8 0.0 0.0052 15.2 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.7 EFX00157.1 - 0.0088 15.0 0.0 0.014 14.3 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.22 EFX00157.1 - 0.014 15.7 0.1 0.034 14.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX00157.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX00157.1 - 0.11 11.2 0.0 0.37 9.5 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_4 PF01565.18 EFX00158.1 - 5.1e-18 64.8 3.6 5.1e-18 64.8 2.5 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 EFX00158.1 - 0.00027 20.7 0.8 0.00092 19.0 0.6 2.0 1 0 0 1 1 1 1 Berberine and berberine like GARS_A PF01071.14 EFX00159.1 - 4.1e-73 245.0 0.0 6.6e-73 244.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 EFX00159.1 - 8.2e-37 125.6 0.1 3e-36 123.8 0.1 2.1 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.17 EFX00159.1 - 1.1e-31 109.8 0.0 4e-31 108.0 0.0 1.9 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.11 EFX00159.1 - 2.2e-23 82.2 0.7 8.2e-23 80.4 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.19 EFX00159.1 - 6.4e-17 61.5 1.2 2.8e-16 59.5 0.8 2.2 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.1 EFX00159.1 - 7.5e-08 31.4 0.0 2.2e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 EFX00159.1 - 1.7e-06 27.9 0.0 4.5e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EFX00159.1 - 0.14 11.9 0.0 0.41 10.5 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain UDPGT PF00201.13 EFX00160.1 - 7.1e-10 38.0 0.0 1.2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.1 EFX00160.1 - 0.002 17.3 0.0 0.0042 16.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 1 Cbl_N3 PF02762.9 EFX00161.1 - 0.016 14.8 0.1 0.065 12.8 0.0 1.9 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, SH2-like domain DUF1469 PF07332.6 EFX00161.1 - 0.1 12.3 0.4 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) Ank_2 PF12796.2 EFX00162.1 - 2.9e-78 258.2 5.2 5.4e-14 52.2 0.1 7.5 4 2 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX00162.1 - 3.4e-44 148.4 11.1 1.9e-05 25.0 0.1 13.4 6 4 9 15 15 15 12 Ankyrin repeats (many copies) Ank PF00023.25 EFX00162.1 - 7.9e-44 145.3 29.1 2.2e-05 24.0 0.0 15.8 17 0 0 17 17 17 11 Ankyrin repeat Ank_3 PF13606.1 EFX00162.1 - 3.6e-34 113.3 8.5 0.00039 20.3 0.0 15.5 16 1 1 17 17 17 6 Ankyrin repeat Ank_5 PF13857.1 EFX00162.1 - 8.5e-34 114.8 26.1 1e-05 25.6 0.0 11.3 7 4 4 13 13 13 9 Ankyrin repeats (many copies) Med3 PF11593.3 EFX00162.1 - 0.0076 15.5 0.1 0.0076 15.5 0.1 2.9 2 1 1 3 3 3 1 Mediator complex subunit 3 fungal B_lectin PF01453.19 EFX00162.1 - 0.014 15.2 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 D-mannose binding lectin Fcf2 PF08698.6 EFX00163.1 - 9.7e-23 80.0 0.3 2.9e-22 78.5 0.1 1.9 1 1 1 2 2 2 1 Fcf2 pre-rRNA processing Endonuclease_NS PF01223.18 EFX00164.1 - 1.4e-58 197.9 0.0 1.8e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease PX PF00787.19 EFX00165.1 - 4.2e-18 65.1 0.0 1.2e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 EFX00165.1 - 5e-14 52.1 11.0 2.9e-08 33.2 0.3 2.3 2 0 0 2 2 2 2 Vps5 C terminal like MFS_2 PF13347.1 EFX00165.1 - 0.00038 18.9 19.0 0.00043 18.8 10.5 2.6 2 1 0 2 2 2 1 MFS/sugar transport protein Pkinase PF00069.20 EFX00166.1 - 5.2e-69 232.2 0.0 6.6e-69 231.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00166.1 - 1.7e-40 138.7 0.0 2.7e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00166.1 - 1.7e-05 23.9 0.0 6.4e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EFX00166.1 - 0.0011 18.0 0.1 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TauD PF02668.11 EFX00167.1 - 5.7e-27 94.9 0.1 7.6e-27 94.5 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Anillin PF08174.6 EFX00168.1 - 9.4e-30 103.4 0.1 2.7e-29 102.0 0.1 1.8 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.24 EFX00168.1 - 3.8e-08 33.4 0.0 1.3e-07 31.7 0.0 2.0 1 0 0 1 1 1 1 PH domain F-box-like PF12937.2 EFX00169.1 - 6.6e-10 38.5 0.0 2.6e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.1 EFX00169.1 - 4.2e-09 35.5 5.3 0.47 10.6 0.0 6.9 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.28 EFX00169.1 - 5.2e-08 31.8 5.2 0.18 11.9 0.0 6.9 7 1 0 7 7 7 1 Leucine Rich Repeat F-box PF00646.28 EFX00169.1 - 1.6e-06 27.6 0.0 6.6e-06 25.6 0.0 2.1 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.2 EFX00169.1 - 2.8e-06 26.7 3.5 0.88 9.2 0.0 6.0 4 2 1 5 5 5 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX00169.1 - 6.5e-06 25.8 1.7 0.027 14.2 0.0 4.4 3 2 2 5 5 5 1 Leucine rich repeat LRR_7 PF13504.1 EFX00169.1 - 0.00011 21.8 12.1 2.6 8.6 0.1 7.2 8 0 0 8 8 8 2 Leucine rich repeat PRANC PF09372.5 EFX00169.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 PRANC domain DUF2457 PF10446.4 EFX00172.1 - 3e-125 418.5 36.1 3e-125 418.5 25.0 3.5 3 1 0 3 3 3 1 Protein of unknown function (DUF2457) zf-Tim10_DDP PF02953.10 EFX00173.1 - 7.2e-19 66.8 0.5 9.3e-19 66.4 0.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PS-DH PF14765.1 EFX00174.1 - 0.0019 17.3 0.2 0.0027 16.9 0.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase RRM_1 PF00076.17 EFX00176.1 - 1.3e-54 181.6 0.0 4.3e-19 67.9 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX00176.1 - 5e-45 151.3 0.1 1.4e-15 56.9 0.0 5.5 5 0 0 5 5 5 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX00176.1 - 4.3e-19 68.1 0.0 1.8e-06 27.7 0.0 4.1 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BUD22 PF09073.5 EFX00176.1 - 0.001 18.2 38.0 0.001 18.2 26.3 3.8 4 0 0 4 4 4 1 BUD22 DUF3753 PF12575.3 EFX00176.1 - 7.9 6.3 4.5 20 5.0 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) PX PF00787.19 EFX00177.1 - 6.3e-14 51.7 0.0 1e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 PX domain SNARE PF05739.14 EFX00177.1 - 7.6e-07 28.7 6.4 7.6e-07 28.7 4.4 1.7 2 0 0 2 2 2 1 SNARE domain BCIP PF13862.1 EFX00177.1 - 0.0012 18.4 0.1 0.0018 17.8 0.1 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DUF4203 PF13886.1 EFX00178.1 - 8.8e-36 123.3 26.3 1.2e-35 122.8 18.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Ribosomal_L13 PF00572.13 EFX00180.1 - 7.6e-29 100.3 0.0 1.4e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L13 DSBA PF01323.15 EFX00180.1 - 0.052 13.1 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 DSBA-like thioredoxin domain Kinesin PF00225.18 EFX00181.1 - 3.9e-54 183.6 0.0 1.1e-52 178.8 0.0 2.6 1 1 1 2 2 2 2 Kinesin motor domain DUF87 PF01935.12 EFX00181.1 - 0.14 11.9 0.1 6 6.6 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF87 Peptidase_M20 PF01546.23 EFX00182.1 - 1.6e-21 76.6 0.0 2.9e-21 75.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Ribonucleas_3_3 PF14622.1 EFX00182.1 - 7.2e-18 64.7 0.0 7.5e-08 32.3 0.0 2.4 2 0 0 2 2 2 2 Ribonuclease-III-like M20_dimer PF07687.9 EFX00182.1 - 1.2e-05 25.0 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain EXS PF03124.9 EFX00183.1 - 1.6e-84 283.8 33.7 2e-83 280.3 23.4 2.0 1 1 0 1 1 1 1 EXS family SPX PF03105.14 EFX00183.1 - 9.3e-58 196.1 0.0 2.2e-57 194.9 0.0 1.6 2 0 0 2 2 2 1 SPX domain Aldedh PF00171.17 EFX00184.1 - 1.2e-63 215.0 0.0 1.7e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family HypD PF01924.11 EFX00184.1 - 0.088 11.5 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase formation hypA family Glycos_transf_3 PF00591.16 EFX00185.1 - 9.1e-61 205.4 0.0 7.1e-38 130.4 0.0 2.4 1 1 1 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 EFX00185.1 - 4e-07 29.5 2.3 1.9e-06 27.3 0.5 2.5 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain CorA PF01544.13 EFX00186.1 - 1.9e-11 43.5 1.2 2.6e-11 43.1 0.9 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3584 PF12128.3 EFX00186.1 - 0.0032 14.9 2.7 0.0042 14.5 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) PhoU PF01895.14 EFX00186.1 - 0.023 15.1 1.1 0.067 13.6 0.7 1.8 1 1 0 1 1 1 0 PhoU domain Vma12 PF11712.3 EFX00186.1 - 0.027 14.1 0.0 0.061 13.0 0.0 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase 7tm_7 PF08395.7 EFX00186.1 - 0.22 10.5 0.6 0.35 9.8 0.2 1.6 1 1 1 2 2 2 0 7tm Chemosensory receptor Glycos_transf_2 PF00535.21 EFX00187.1 - 5.9e-35 120.4 0.0 7e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EFX00187.1 - 3.2e-13 50.0 0.0 8e-13 48.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EFX00187.1 - 1.7e-10 40.4 0.0 2.2e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EFX00187.1 - 0.00011 21.5 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 EFX00187.1 - 0.12 12.6 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Actin PF00022.14 EFX00188.1 - 1.5e-91 306.7 0.0 1.8e-91 306.5 0.0 1.1 1 0 0 1 1 1 1 Actin Acetyltransf_7 PF13508.1 EFX00190.1 - 3.1e-06 27.2 0.0 7.5e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX00190.1 - 0.00031 20.6 0.2 0.0006 19.8 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFX00190.1 - 0.0023 18.0 0.0 0.0045 17.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GCIP PF13324.1 EFX00191.1 - 4.5e-05 22.8 3.2 0.00045 19.5 1.5 2.8 4 0 0 4 4 4 1 Grap2 and cyclin-D-interacting GET2 PF08690.5 EFX00191.1 - 0.011 15.0 0.8 0.016 14.4 0.6 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 CDC45 PF02724.9 EFX00191.1 - 0.12 10.3 3.8 0.17 9.8 2.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 EFX00191.1 - 0.25 9.2 6.0 0.31 8.9 4.2 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.6 EFX00191.1 - 0.38 8.8 2.3 0.53 8.3 1.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.8 EFX00191.1 - 1.9 8.0 7.9 3.9 7.0 5.5 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.4 EFX00191.1 - 2.3 6.8 17.4 3.4 6.2 12.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 EFX00191.1 - 8.2 5.9 10.4 14 5.1 7.2 1.3 1 0 0 1 1 1 0 Nucleoplasmin Adenylsucc_synt PF00709.16 EFX00192.1 - 5.9e-148 493.0 0.0 6.6e-148 492.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Peptidase_C13 PF01650.13 EFX00194.1 - 0.018 14.3 0.1 0.038 13.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase C13 family MFS_1 PF07690.11 EFX00195.1 - 1.1e-17 63.8 44.3 3.9e-09 35.6 8.3 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily ATG22 PF11700.3 EFX00195.1 - 5.3e-07 28.4 8.6 7.6e-07 27.9 0.1 2.9 2 1 0 3 3 3 2 Vacuole effluxer Atg22 like MFS_2 PF13347.1 EFX00195.1 - 6.4e-05 21.5 15.1 0.00023 19.6 2.9 3.3 3 0 0 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.19 EFX00195.1 - 0.036 12.6 14.6 0.018 13.6 4.4 3.2 3 0 0 3 3 3 0 Sugar (and other) transporter TraL PF07178.6 EFX00195.1 - 0.049 13.6 0.7 7.1 6.7 0.0 3.2 2 1 0 2 2 2 0 TraL protein MFS_1_like PF12832.2 EFX00195.1 - 0.26 11.0 0.1 0.26 11.0 0.1 4.0 5 0 0 5 5 5 0 MFS_1 like family Esterase PF00756.15 EFX00196.1 - 8.4e-53 179.3 0.1 1e-52 179.0 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 EFX00196.1 - 1.3e-06 28.2 0.0 1.8e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX00196.1 - 3.4e-06 27.1 0.2 4.5e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 EFX00196.1 - 0.0021 17.3 0.0 0.006 15.8 0.0 1.7 1 1 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.16 EFX00196.1 - 0.0037 16.5 0.0 0.0052 16.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 EFX00196.1 - 0.0062 16.1 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 EFX00196.1 - 0.017 14.0 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Ras PF00071.17 EFX00197.1 - 7.7e-18 64.3 0.2 4.6e-16 58.6 0.0 2.1 1 1 1 2 2 2 2 Ras family Miro PF08477.8 EFX00197.1 - 1.7e-15 57.5 0.2 1.2e-11 45.1 0.0 3.1 2 1 1 3 3 3 2 Miro-like protein Gtr1_RagA PF04670.7 EFX00197.1 - 0.0061 15.7 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 EFX00197.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Abi PF02517.11 EFX00198.1 - 1.3e-15 57.2 6.6 1.3e-15 57.2 4.6 2.8 2 1 1 3 3 3 1 CAAX protease self-immunity UQ_con PF00179.21 EFX00199.1 - 1e-37 128.6 0.0 1.3e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 EFX00199.1 - 5.4e-07 29.1 0.1 9.6e-07 28.3 0.1 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.1 EFX00199.1 - 0.0016 18.1 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 EFX00199.1 - 0.066 12.8 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain Peptidase_C12 PF01088.16 EFX00200.1 - 2.3e-10 40.0 0.0 2.7e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Isochorismatase PF00857.15 EFX00201.1 - 8.9e-28 97.3 1.4 1.3e-27 96.7 1.0 1.3 1 0 0 1 1 1 1 Isochorismatase family AXH PF08517.7 EFX00201.1 - 0.097 12.8 0.0 0.5 10.5 0.0 2.0 2 0 0 2 2 2 0 Ataxin-1 and HBP1 module (AXH) SSrecog PF03531.9 EFX00202.1 - 1.6e-79 266.3 0.1 3.8e-79 265.1 0.1 1.6 1 1 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 EFX00202.1 - 1.6e-26 92.1 0.2 1.3e-24 85.9 0.0 2.7 3 0 0 3 3 3 1 Histone chaperone Rttp106-like DUF2201_N PF13203.1 EFX00202.1 - 0.22 10.6 0.0 0.22 10.6 0.0 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain CDC45 PF02724.9 EFX00202.1 - 6.2 4.7 13.4 9.8 4.0 9.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Tub_2 PF04525.7 EFX00203.1 - 2.7e-24 85.5 0.0 3.2e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 Tubby C 2 Exo_endo_phos PF03372.18 EFX00204.1 - 3.2e-20 73.1 0.0 4.6e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 EFX00204.1 - 2.3e-12 46.2 9.9 5.6e-08 32.2 0.4 2.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX00204.1 - 9.5e-07 28.4 5.7 3.1e-05 23.6 0.5 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 EFX00204.1 - 0.00014 21.4 6.4 2.1 8.7 0.0 4.7 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 EFX00204.1 - 0.016 15.2 8.4 8.7 7.0 0.1 4.6 4 0 0 4 4 4 0 Leucine rich repeat RseA_N PF03872.8 EFX00204.1 - 0.082 13.2 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain Piwi PF02171.12 EFX00205.1 - 1.7e-51 175.0 0.1 2.3e-40 138.4 0.0 3.1 3 0 0 3 3 3 3 Piwi domain Collagen_bind_2 PF12904.2 EFX00206.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative collagen-binding domain of a collagenase Glyoxalase_3 PF13468.1 EFX00207.1 - 2.2e-22 79.7 0.0 3.9e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain SSB PF00436.20 EFX00208.1 - 9e-17 60.8 0.0 1.1e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family MFS_1 PF07690.11 EFX00209.1 - 7.8e-38 130.0 50.8 1.7e-22 79.6 15.8 3.7 2 1 1 3 3 3 3 Major Facilitator Superfamily Methyltransf_23 PF13489.1 EFX00210.1 - 2.5e-06 27.2 0.1 0.017 14.8 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain MFS_1 PF07690.11 EFX00211.1 - 1.4e-38 132.5 28.5 1.4e-38 132.5 19.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX00211.1 - 4.6e-06 25.1 4.2 7.1e-06 24.5 2.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3099 PF11298.3 EFX00211.1 - 1.3 8.8 5.0 4 7.2 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) Glyco_hydro_43 PF04616.9 EFX00212.1 - 8.3e-93 310.5 0.0 3.2e-92 308.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 FAD_binding_2 PF00890.19 EFX00213.1 - 1.9e-92 310.3 4.6 2.2e-92 310.1 3.2 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 EFX00213.1 - 6.8e-09 35.6 0.7 2.5e-08 33.8 0.2 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 EFX00213.1 - 3.8e-07 29.4 0.3 1.1e-06 27.9 0.2 1.7 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX00213.1 - 6.2e-07 28.6 5.4 1.2e-06 27.7 0.4 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX00213.1 - 7.9e-07 29.1 0.0 0.00015 21.7 0.2 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX00213.1 - 2.4e-05 23.5 0.0 5.8e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.17 EFX00213.1 - 5.8e-05 22.1 0.2 5.8e-05 22.1 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 EFX00213.1 - 0.00016 21.7 0.4 0.00061 19.9 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFX00213.1 - 0.00026 20.1 0.1 0.00043 19.4 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX00213.1 - 0.002 16.6 0.4 0.002 16.6 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.7 EFX00213.1 - 0.008 15.1 0.2 0.014 14.3 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 EFX00213.1 - 0.0083 15.9 0.1 0.022 14.5 0.1 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFX00213.1 - 0.012 15.9 1.0 0.042 14.2 0.7 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4449 PF14613.1 EFX00214.1 - 0.001 18.9 0.0 0.0072 16.2 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) DUF4208 PF13907.1 EFX00214.1 - 0.05 13.8 0.1 0.18 12.0 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Rho_Binding PF08912.6 EFX00214.1 - 0.065 13.5 0.1 0.22 11.8 0.1 1.9 1 0 0 1 1 1 0 Rho Binding Exo70 PF03081.10 EFX00214.1 - 0.2 10.3 2.7 8 5.1 0.1 2.4 2 0 0 2 2 2 0 Exo70 exocyst complex subunit ATP-synt_B PF00430.13 EFX00214.1 - 0.29 10.9 4.2 0.79 9.5 2.9 1.8 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Cep57_CLD_2 PF14197.1 EFX00214.1 - 4.6 7.2 7.8 1.3 9.0 0.0 3.4 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Cnd3 PF12719.2 EFX00217.1 - 1.3e-90 303.4 0.1 5.2e-90 301.4 0.0 2.1 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 EFX00217.1 - 5.5e-08 32.9 19.3 4.1e-05 23.7 0.7 5.8 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.17 EFX00217.1 - 0.0077 16.2 14.7 0.2 11.7 0.0 6.2 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.1 EFX00217.1 - 0.021 15.2 0.8 0.021 15.2 0.6 7.0 4 1 4 8 8 8 0 HEAT-like repeat SelP_N PF04592.9 EFX00219.1 - 0.55 9.5 19.2 0.043 13.1 7.5 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region LrgB PF04172.11 EFX00220.1 - 1.1e-28 99.8 4.3 1.1e-28 99.8 2.9 1.9 2 0 0 2 2 2 1 LrgB-like family DUF1614 PF07758.6 EFX00220.1 - 0.00087 19.0 1.4 0.00087 19.0 1.0 2.4 2 1 1 3 3 3 1 Protein of unknown function (DUF1614) ERp29 PF07749.7 EFX00222.1 - 0.27 11.8 2.3 10 6.8 0.0 2.8 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Porphobil_deam PF01379.15 EFX00223.1 - 5e-74 247.8 0.0 6.6e-74 247.4 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 EFX00223.1 - 2.2e-18 66.1 0.4 3.7e-18 65.3 0.3 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain DUF2834 PF11196.3 EFX00224.1 - 5.2 7.3 10.9 2 8.6 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2834) Clr5 PF14420.1 EFX00225.1 - 2.4e-19 68.9 1.8 4.1e-19 68.2 1.2 1.4 1 0 0 1 1 1 1 Clr5 domain DUF2404 PF10296.4 EFX00226.1 - 8e-07 29.1 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) MUG113 PF13455.1 EFX00227.1 - 1.9e-30 105.1 0.1 2.8e-30 104.6 0.1 1.2 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.4 EFX00227.1 - 3.2e-21 75.5 0.0 5.4e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 T5orf172 domain TPR_2 PF07719.12 EFX00228.1 - 3.6e-23 79.5 26.4 0.0096 15.7 0.1 12.0 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_11 PF13414.1 EFX00228.1 - 3.8e-23 80.8 29.2 4.3e-05 23.0 0.0 10.1 8 2 2 11 11 11 5 TPR repeat TPR_1 PF00515.23 EFX00228.1 - 1.8e-20 71.5 23.1 0.00066 19.1 0.1 11.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_8 PF13181.1 EFX00228.1 - 2.1e-20 70.8 20.4 0.0025 17.4 0.1 11.3 11 1 0 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFX00228.1 - 1.8e-17 63.0 22.7 0.00036 20.3 0.1 9.7 7 3 4 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00228.1 - 2e-14 53.6 23.9 0.0012 19.1 0.1 10.4 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFX00228.1 - 2e-10 39.6 14.5 0.0012 18.4 0.0 9.8 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX00228.1 - 2.3e-08 33.9 21.7 0.074 13.5 0.0 10.5 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX00228.1 - 9.7e-08 31.9 31.9 0.025 15.2 0.0 13.0 14 1 1 15 15 12 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX00228.1 - 0.00016 22.2 49.9 0.0038 17.8 0.1 10.8 11 2 1 12 12 11 4 Tetratricopeptide repeat TPR_10 PF13374.1 EFX00228.1 - 0.06 13.3 16.3 6 6.9 0.0 7.9 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_17 PF13431.1 EFX00228.1 - 3.3 8.1 19.1 1.6 9.1 0.1 7.9 10 0 0 10 10 8 0 Tetratricopeptide repeat Apolipoprotein PF01442.13 EFX00230.1 - 0.00096 18.7 3.8 0.46 9.9 0.0 4.2 3 1 0 3 3 3 1 Apolipoprotein A1/A4/E domain Dynamin_N PF00350.18 EFX00230.1 - 0.044 13.6 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Dynamin family DUF4407 PF14362.1 EFX00230.1 - 0.062 12.2 5.2 0.66 8.8 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Occludin_ELL PF07303.8 EFX00230.1 - 1 10.1 3.8 1.3 9.7 0.6 2.7 2 1 1 3 3 3 0 Occludin homology domain IncA PF04156.9 EFX00230.1 - 1.1 8.8 4.8 5.7 6.4 2.1 2.8 2 1 0 2 2 2 0 IncA protein RNase_P_pop3 PF08228.6 EFX00231.1 - 1.3e-05 25.1 0.0 2.2e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 RNase P subunit Pop3 NRDE PF05742.7 EFX00232.1 - 6.6e-38 130.5 0.0 2.7e-32 112.1 0.0 2.0 2 0 0 2 2 2 2 NRDE protein Methyltransf_23 PF13489.1 EFX00233.1 - 1.4e-19 70.3 0.0 3.3e-19 69.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00233.1 - 5.3e-10 39.6 0.0 9.9e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00233.1 - 6e-08 33.0 0.0 3.2e-07 30.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00233.1 - 6.2e-08 33.2 0.0 4.6e-07 30.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX00233.1 - 8.2e-07 29.3 0.0 2.1e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00233.1 - 2.6e-06 27.1 0.0 1.1e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX00233.1 - 0.00045 19.4 0.0 0.0056 15.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFX00233.1 - 0.016 15.2 0.0 0.067 13.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain CDK2AP PF09806.4 EFX00233.1 - 0.029 14.6 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein MTS PF05175.9 EFX00233.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DUF2457 PF10446.4 EFX00233.1 - 0.24 10.0 5.6 0.38 9.4 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ebola_NP PF05505.7 EFX00233.1 - 1.3 7.0 5.4 1.6 6.6 3.7 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Nop14 PF04147.7 EFX00233.1 - 6.2 4.5 6.5 7.7 4.2 4.5 1.1 1 0 0 1 1 1 0 Nop14-like family Fungal_trans PF04082.13 EFX00234.1 - 1.9e-11 43.3 0.8 3.1e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX00234.1 - 4.2e-06 26.5 15.5 8.3e-06 25.6 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.8 EFX00234.1 - 0.023 14.6 34.2 0.2 11.4 15.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Vpu PF00558.14 EFX00234.1 - 0.23 11.0 0.1 0.59 9.7 0.1 1.6 1 0 0 1 1 1 0 Vpu protein Suf PF05843.9 EFX00234.1 - 1.7 8.2 22.0 0.18 11.4 7.2 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SET PF00856.23 EFX00235.1 - 2.2e-07 31.3 0.0 0.0093 16.2 0.0 3.0 3 0 0 3 3 3 2 SET domain zf-MYND PF01753.13 EFX00235.1 - 0.021 14.6 0.8 0.021 14.6 0.5 2.8 3 1 0 3 3 3 0 MYND finger TPR_11 PF13414.1 EFX00235.1 - 0.9 9.2 5.4 0.25 10.9 0.3 2.5 2 1 0 2 2 2 0 TPR repeat TPR_16 PF13432.1 EFX00235.1 - 2.4 8.9 12.3 0.2 12.3 2.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Colipase-like PF15083.1 EFX00236.1 - 0.00036 20.4 9.4 0.075 12.9 1.2 2.3 2 0 0 2 2 2 2 Colipase-like Gamma-thionin PF00304.15 EFX00236.1 - 0.6 10.1 11.7 2.8 8.0 1.5 2.9 2 0 0 2 2 2 0 Gamma-thionin family Auxin_repressed PF05564.7 EFX00236.1 - 3.1 8.4 7.7 1.1 9.9 0.2 2.3 2 1 0 2 2 2 0 Dormancy/auxin associated protein Calpain_inhib PF00748.14 EFX00236.1 - 5.1 7.4 8.9 0.48 10.7 1.5 2.1 2 0 0 2 2 2 0 Calpain inhibitor Enamelin PF15362.1 EFX00236.1 - 7 4.5 6.1 9.5 4.1 4.2 1.1 1 0 0 1 1 1 0 Enamelin zf-MYND PF01753.13 EFX00237.1 - 5e-05 23.0 13.8 0.00012 21.9 9.6 1.7 1 0 0 1 1 1 1 MYND finger ACPS PF01648.15 EFX00237.1 - 0.013 15.2 0.0 4.2 7.2 0.0 2.4 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase superfamily Ecl1 PF12855.2 EFX00237.1 - 4.9 6.5 7.3 1.9 7.8 2.8 2.0 2 0 0 2 2 2 0 Life-span regulatory factor PXA PF02194.10 EFX00238.1 - 8.4e-36 123.2 0.2 1.3e-35 122.6 0.1 1.2 1 0 0 1 1 1 1 PXA domain MARVEL PF01284.18 EFX00238.1 - 0.034 13.9 0.6 1 9.1 0.2 2.6 2 0 0 2 2 2 0 Membrane-associating domain PalH PF08733.5 EFX00239.1 - 3.6e-108 361.5 0.0 4.6e-108 361.1 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 Lipase_GDSL_2 PF13472.1 EFX00241.1 - 9.1e-19 68.2 0.0 1.6e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFX00241.1 - 1.4e-15 57.8 0.0 2.5e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Acetyltransf_1 PF00583.19 EFX00242.1 - 8.6e-10 38.5 0.0 5.4e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFX00242.1 - 0.00062 19.4 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 EFX00242.1 - 0.00079 19.5 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFX00242.1 - 0.0033 17.3 0.0 0.0066 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFX00242.1 - 0.024 14.8 0.0 0.075 13.2 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFX00242.1 - 0.06 13.4 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Zip PF02535.17 EFX00244.1 - 3.1e-30 105.3 4.4 7.5e-30 104.0 3.0 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter Xpo1 PF08389.7 EFX00245.1 - 1.2e-36 125.8 0.2 2.2e-35 121.7 0.0 3.0 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.17 EFX00245.1 - 3.7e-05 23.4 0.3 3.3 8.0 0.0 5.0 4 0 0 4 4 4 2 HEAT repeat UDPGT PF00201.13 EFX00246.1 - 1e-05 24.2 0.0 1.4e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DEAD PF00270.24 EFX00247.1 - 1.3e-41 141.9 0.7 2.2e-41 141.1 0.5 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX00247.1 - 1.6e-22 79.1 0.1 2.5e-13 49.6 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 EFX00247.1 - 1.8e-05 24.6 0.1 6.6e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DPM3 PF08285.6 EFX00248.1 - 7.4e-30 102.6 0.1 8.1e-30 102.5 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CFEM PF05730.6 EFX00250.1 - 7.2e-11 41.7 10.5 7.2e-11 41.7 7.3 2.4 2 1 0 2 2 2 1 CFEM domain Atrophin-1 PF03154.10 EFX00250.1 - 5.5 4.9 16.9 6.9 4.6 11.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF1675 PF07897.6 EFX00250.1 - 6.8 6.4 9.8 8.4 6.1 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) PRKCSH_1 PF13015.1 EFX00251.1 - 9.4e-28 96.6 1.2 9.4e-28 96.6 0.9 1.9 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH-like PF12999.2 EFX00251.1 - 2.9e-26 92.1 0.5 6.9e-26 90.8 0.0 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH PF07915.8 EFX00251.1 - 9.8e-10 39.1 0.8 4e-09 37.1 0.5 2.1 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein NPV_P10 PF05531.7 EFX00251.1 - 0.021 15.0 1.3 0.12 12.6 0.1 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.12 EFX00251.1 - 0.093 12.3 0.3 0.093 12.3 0.2 3.0 3 1 0 3 3 3 0 Prefoldin subunit DUF3086 PF11285.3 EFX00251.1 - 0.11 11.2 6.9 1.8 7.3 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3086) OmpH PF03938.9 EFX00251.1 - 0.28 11.1 9.3 3.7 7.4 4.1 2.8 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Fib_alpha PF08702.5 EFX00251.1 - 0.74 9.9 7.4 0.88 9.6 0.1 2.7 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family CorA PF01544.13 EFX00251.1 - 0.78 8.7 3.0 1 8.2 0.3 2.2 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Syntaxin-6_N PF09177.6 EFX00251.1 - 0.79 10.1 11.1 8.9 6.7 0.3 3.5 3 0 0 3 3 3 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.7 EFX00251.1 - 0.97 9.1 17.7 2.1 8.0 5.0 3.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Fzo_mitofusin PF04799.8 EFX00251.1 - 1.1 8.5 3.6 4.2 6.7 0.6 2.4 2 0 0 2 2 2 0 fzo-like conserved region PspA_IM30 PF04012.7 EFX00251.1 - 1.3 8.2 17.8 1.3 8.3 6.2 3.2 3 0 0 3 3 3 0 PspA/IM30 family WXG100 PF06013.7 EFX00251.1 - 2.7 8.0 5.6 8.5 6.4 0.0 3.5 4 0 0 4 4 3 0 Proteins of 100 residues with WXG DUF1664 PF07889.7 EFX00251.1 - 3.7 7.3 8.5 4.6 7.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) NuA4 PF09340.5 EFX00251.1 - 4.4 7.0 8.0 27 4.5 0.0 3.7 2 1 1 3 3 3 0 Histone acetyltransferase subunit NuA4 Prefoldin_2 PF01920.15 EFX00251.1 - 4.8 7.0 17.3 2.3 8.0 1.7 3.6 3 1 1 4 4 4 0 Prefoldin subunit PEARLI-4 PF05278.7 EFX00251.1 - 5.4 6.3 11.9 1.3 8.2 5.7 1.8 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4200 PF13863.1 EFX00251.1 - 6.8 6.6 20.2 6.8 6.6 6.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) V_ATPase_I PF01496.14 EFX00251.1 - 7.7 4.2 8.2 2.2 6.0 3.0 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TMF_DNA_bd PF12329.3 EFX00251.1 - 8.5 6.2 22.1 4.3 7.2 1.4 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Med4 PF10018.4 EFX00251.1 - 8.8 5.6 10.6 1.1 8.6 0.8 2.6 3 0 0 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 ApbA_C PF08546.6 EFX00252.1 - 1.1e-32 112.6 0.0 1.8e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFX00252.1 - 3.8e-21 75.1 0.1 6e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Afi1 PF07792.7 EFX00253.1 - 1.1e-64 216.7 2.7 4.9e-63 211.4 1.9 2.5 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 EFX00253.1 - 1.6e-35 121.2 0.0 3e-35 120.3 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 EFX00253.1 - 4.9e-06 25.2 0.1 0.061 11.7 0.0 3.8 3 1 1 4 4 4 2 Transport protein Avl9 TFIIA PF03153.8 EFX00253.1 - 0.02 14.7 19.5 0.042 13.7 13.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRN3 PF05327.6 EFX00253.1 - 0.089 10.8 2.6 0.13 10.3 1.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2347 PF09804.4 EFX00253.1 - 0.14 11.4 0.0 0.84 8.8 0.0 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) Cwf_Cwc_15 PF04889.7 EFX00253.1 - 0.18 11.4 14.1 0.32 10.6 9.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.8 EFX00253.1 - 0.79 9.3 13.4 1.9 8.0 9.3 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.9 EFX00253.1 - 2.2 6.1 13.7 3.9 5.3 9.5 1.3 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.5 EFX00253.1 - 3.2 6.7 17.2 5.3 5.9 11.9 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.7 EFX00253.1 - 6.8 4.4 21.8 10 3.8 15.1 1.2 1 0 0 1 1 1 0 Nop14-like family ABC2_membrane PF01061.19 EFX00255.1 - 1.2e-95 318.6 56.1 1.5e-48 164.7 14.7 2.8 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 EFX00255.1 - 9.9e-39 131.1 5.7 2.1e-33 114.0 0.0 3.1 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.22 EFX00255.1 - 4.8e-35 120.8 0.0 1.6e-16 60.8 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.1 EFX00255.1 - 2.2e-23 82.1 0.0 7.7e-23 80.3 0.0 2.0 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 EFX00255.1 - 5.2e-08 32.5 0.1 8.7e-05 21.9 0.1 2.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX00255.1 - 2.7e-07 30.7 0.1 6.3e-05 23.0 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 EFX00255.1 - 7.2e-07 28.5 0.0 0.00027 20.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 cobW PF02492.14 EFX00255.1 - 2.3e-06 27.1 1.0 0.0014 18.0 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EFX00255.1 - 1.6e-05 24.7 0.1 0.0083 16.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFX00255.1 - 0.00034 20.3 0.3 0.29 10.8 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 EFX00255.1 - 0.00074 20.3 0.0 0.042 14.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX00255.1 - 0.00099 19.2 0.1 1 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFX00255.1 - 0.0013 18.2 0.6 0.042 13.3 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX00255.1 - 0.0015 18.8 0.0 0.069 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.1 EFX00255.1 - 0.0044 17.0 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFX00255.1 - 0.0047 17.1 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EFX00255.1 - 0.0082 16.1 0.2 1.8 8.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 EFX00255.1 - 0.012 15.2 1.3 4.7 6.8 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 EFX00255.1 - 0.021 14.5 1.5 1.9 8.0 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.1 EFX00255.1 - 0.024 14.2 0.1 4 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EFX00255.1 - 0.047 12.7 0.1 4.9 6.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.12 EFX00255.1 - 0.051 13.0 0.2 6.1 6.2 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_24 PF13479.1 EFX00255.1 - 0.088 12.3 1.9 1.5 8.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 EFX00255.1 - 0.12 12.0 0.0 9 5.9 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase Miro PF08477.8 EFX00255.1 - 0.13 12.7 0.0 27 5.2 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein AAA_14 PF13173.1 EFX00255.1 - 0.17 11.7 0.0 23 4.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EFX00255.1 - 0.34 10.3 0.8 5 6.6 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC2_membrane_3 PF12698.2 EFX00255.1 - 2.1 7.2 51.6 2 7.3 13.6 3.5 2 1 1 3 3 3 0 ABC-2 family transporter protein Fasciclin PF02469.17 EFX00256.1 - 7.5e-22 77.6 1.6 1.9e-17 63.4 0.3 3.1 2 1 0 2 2 2 2 Fasciclin domain Swi5 PF07061.6 EFX00258.1 - 3.7e-16 58.6 0.1 5.2e-16 58.1 0.1 1.3 1 0 0 1 1 1 1 Swi5 p450 PF00067.17 EFX00260.1 - 1.4e-84 284.3 0.0 1.6e-84 284.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PLAC8 PF04749.12 EFX00261.1 - 4.3e-23 81.8 12.0 5.5e-23 81.5 8.3 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4246 PF14033.1 EFX00262.1 - 3.9e-156 520.5 0.0 7.4e-156 519.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) Rrp15p PF07890.7 EFX00262.1 - 8.4e-34 116.4 7.6 8.4e-34 116.4 5.3 1.7 2 0 0 2 2 2 1 Rrp15p Ammonium_transp PF00909.16 EFX00263.1 - 1.4e-118 395.8 26.9 1.6e-118 395.6 18.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family CLP_protease PF00574.18 EFX00264.1 - 8.1e-22 77.7 0.3 1.6e-12 47.4 0.0 2.9 2 1 1 3 3 3 2 Clp protease Rod-binding PF10135.4 EFX00265.1 - 0.098 12.6 0.8 0.16 11.9 0.6 1.4 1 0 0 1 1 1 0 Rod binding protein TPR_12 PF13424.1 EFX00266.1 - 5.5e-17 61.4 6.3 8e-08 32.1 0.0 4.5 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00266.1 - 1.1e-09 37.4 3.2 0.0057 16.4 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX00266.1 - 1.7e-07 30.5 0.0 0.0079 15.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX00266.1 - 1.5e-05 24.5 0.8 0.33 10.6 0.1 4.0 4 0 0 4 4 4 2 TPR repeat TPR_16 PF13432.1 EFX00266.1 - 0.00022 21.7 7.0 0.021 15.4 0.1 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFX00266.1 - 0.00049 19.6 0.7 1.3 8.9 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFX00266.1 - 0.00095 19.0 9.2 0.41 10.6 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat NB-ARC PF00931.17 EFX00266.1 - 0.0019 17.1 0.0 0.004 16.0 0.0 1.5 1 1 0 1 1 1 1 NB-ARC domain KaiC PF06745.8 EFX00266.1 - 0.21 10.6 0.0 0.35 9.9 0.0 1.2 1 0 0 1 1 1 0 KaiC Tic20 PF09685.5 EFX00267.1 - 2.3e-05 24.3 1.0 4.4e-05 23.4 0.7 1.4 1 0 0 1 1 1 1 Tic20-like protein Ribosomal_L10 PF00466.15 EFX00267.1 - 0.2 11.5 0.0 2.5 8.0 0.0 2.2 2 1 0 2 2 2 0 Ribosomal protein L10 OPT PF03169.10 EFX00268.1 - 1.7e-179 598.2 52.8 2e-179 598.0 36.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Sec1 PF00995.18 EFX00270.1 - 1.1e-141 473.2 0.0 1.3e-141 473.0 0.0 1.1 1 0 0 1 1 1 1 Sec1 family CDP-OH_P_transf PF01066.16 EFX00270.1 - 1.4e-16 60.6 2.3 3e-16 59.5 1.6 1.5 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase B12-binding PF02310.14 EFX00270.1 - 0.049 13.4 0.1 0.42 10.4 0.0 2.3 2 0 0 2 2 2 0 B12 binding domain BEX PF04538.7 EFX00270.1 - 0.11 12.7 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Brain expressed X-linked like family Glyco_hydro_39 PF01229.12 EFX00271.1 - 7.4e-06 24.6 0.0 1.1e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Ribosomal_S13 PF00416.17 EFX00275.1 - 1.3e-38 131.7 1.1 1.6e-38 131.4 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 ClpS PF02617.12 EFX00275.1 - 0.059 13.0 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS PP28 PF10252.4 EFX00275.1 - 0.079 12.9 0.4 0.16 12.0 0.3 1.5 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 zf-C3HC4_3 PF13920.1 EFX00276.1 - 0.31 10.7 4.3 0.72 9.5 2.9 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peptidase_S49_N PF08496.5 EFX00276.1 - 1 9.1 4.6 2.2 8.0 3.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PNPOx_C PF10590.4 EFX00277.1 - 2.2e-11 43.0 4.3 3e-11 42.6 3.0 1.2 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region AAA PF00004.24 EFX00278.1 - 4.1e-18 65.8 0.0 7.1e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFX00278.1 - 0.0053 15.8 0.0 0.011 14.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EFX00278.1 - 0.0095 16.7 0.1 0.059 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX00278.1 - 0.0097 16.0 0.3 0.049 13.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX00278.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 EFX00278.1 - 0.046 13.5 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EFX00278.1 - 0.051 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 EFX00278.1 - 0.098 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.8 EFX00278.1 - 0.13 10.9 0.1 0.26 9.9 0.1 1.4 1 0 0 1 1 1 0 TIP49 C-terminus Wound_ind PF08186.6 EFX00279.1 - 0.13 12.1 2.2 0.37 10.7 1.5 1.7 1 0 0 1 1 1 0 Wound-inducible basic protein family KH_1 PF00013.24 EFX00280.1 - 2.1e-05 24.0 2.4 5.4e-05 22.7 1.7 1.6 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EFX00280.1 - 0.051 13.2 0.6 0.12 12.1 0.4 1.6 1 0 0 1 1 1 0 KH domain SAM_2 PF07647.12 EFX00281.1 - 4.1e-17 61.7 0.0 8.2e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 EFX00281.1 - 4.1e-15 56.0 0.0 4.9e-13 49.3 0.0 2.4 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.25 EFX00281.1 - 6.7e-15 55.0 0.0 1.3e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) GFA PF04828.9 EFX00282.1 - 1.3e-11 44.2 2.4 2.9e-06 27.1 0.1 2.6 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme zf-ribbon_3 PF13248.1 EFX00282.1 - 0.0012 17.9 0.4 0.81 8.9 0.0 3.2 2 0 0 2 2 2 2 zinc-ribbon domain DUF2321 PF10083.4 EFX00282.1 - 0.0027 17.2 2.7 0.28 10.6 0.0 2.4 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2321) Nudix_N_2 PF14803.1 EFX00282.1 - 0.025 14.2 8.0 0.033 13.8 0.0 3.2 3 0 0 3 3 3 0 Nudix N-terminal zf-NADH-PPase PF09297.6 EFX00282.1 - 0.15 11.6 5.0 0.23 10.9 0.1 2.8 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.1 EFX00282.1 - 0.31 10.5 5.0 1.4 8.4 0.2 3.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4 PF00097.20 EFX00282.1 - 3.7 7.2 9.6 8.1 6.2 0.1 3.6 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) NOB1_Zn_bind PF08772.6 EFX00282.1 - 6 6.7 7.3 6.7 6.6 0.1 3.1 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like MMR_HSR1 PF01926.18 EFX00284.1 - 0.00053 19.9 0.0 0.0015 18.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFX00284.1 - 0.016 14.4 0.0 0.042 13.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AIG1 PF04548.11 EFX00284.1 - 0.048 12.7 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Med10 PF09748.4 EFX00284.1 - 0.077 12.8 0.0 0.94 9.3 0.0 2.5 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex fn3 PF00041.16 EFX00284.1 - 0.093 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type III domain AAA_29 PF13555.1 EFX00284.1 - 0.11 12.0 0.0 0.3 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AOX PF01786.12 EFX00285.1 - 5.9e-84 280.5 0.0 9e-84 280.0 0.0 1.3 1 0 0 1 1 1 1 Alternative oxidase O-FucT PF10250.4 EFX00285.1 - 1.2e-06 27.8 0.0 2.9e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Ran-binding PF05508.6 EFX00287.1 - 9.3e-86 287.4 0.0 1.2e-85 287.1 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein PINIT PF14324.1 EFX00288.1 - 3.2e-39 134.2 0.0 5.6e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.15 EFX00288.1 - 6.2e-22 76.8 3.9 1.1e-21 76.1 2.7 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 EFX00288.1 - 6.3e-07 28.7 0.0 1.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.3 EFX00288.1 - 6.6e-07 28.7 0.7 1.3e-06 27.8 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 EFX00288.1 - 0.028 14.3 2.9 0.052 13.4 2.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Histone PF00125.19 EFX00289.1 - 5.7e-26 90.4 0.2 8.2e-26 89.9 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EFX00289.1 - 0.001 19.1 0.0 0.0013 18.8 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EFX00289.1 - 0.028 14.4 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PDEase_I PF00233.14 EFX00291.1 - 8.6e-42 143.5 4.4 1.3e-39 136.4 0.0 2.6 3 0 0 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase TGS PF02824.16 EFX00292.1 - 2.5e-23 81.6 0.1 4.9e-23 80.7 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 EFX00292.1 - 7.1e-18 64.6 0.0 2.6e-17 62.8 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX00292.1 - 4.1e-09 35.8 0.1 2.4e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EFX00292.1 - 9.1e-05 21.9 0.2 0.36 10.2 0.0 3.8 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 EFX00292.1 - 0.00013 21.8 0.2 0.022 14.6 0.0 2.4 1 1 1 2 2 2 2 Dynamin family ArgK PF03308.11 EFX00292.1 - 0.036 12.8 0.2 0.12 11.1 0.1 1.8 2 0 0 2 2 2 0 ArgK protein ABC_tran PF00005.22 EFX00292.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Pkinase PF00069.20 EFX00293.1 - 3e-58 197.0 0.0 4.3e-58 196.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00293.1 - 9e-20 70.8 0.0 1.4e-18 66.9 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 EFX00294.1 - 1.5e-56 191.4 0.0 2.4e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00294.1 - 8.3e-30 103.7 0.0 1.3e-29 103.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00294.1 - 5.6e-06 25.5 0.0 2.7e-05 23.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 EFX00294.1 - 0.0018 17.3 0.0 0.0036 16.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX00294.1 - 0.012 15.3 0.1 0.038 13.7 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 EFX00294.1 - 0.3 9.8 0.0 0.9 8.2 0.0 1.6 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Sugar_tr PF00083.19 EFX00295.1 - 2.6e-26 92.2 19.4 2.7e-23 82.2 4.8 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFX00295.1 - 1.4e-08 33.8 26.1 3.6e-06 25.9 7.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX00295.1 - 0.0029 16.0 5.0 0.0029 16.0 3.4 2.5 1 1 1 2 2 2 2 MFS/sugar transport protein CBM_21 PF03370.8 EFX00296.1 - 4.1e-31 107.2 0.0 9.4e-31 106.1 0.0 1.6 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit ATP_transf PF09830.4 EFX00297.1 - 3.3e-19 68.4 0.0 5.2e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase Methyltransf_23 PF13489.1 EFX00298.1 - 6.1e-16 58.5 0.0 9.1e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00298.1 - 1.3e-07 32.1 0.0 6e-06 26.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00298.1 - 2.2e-06 27.3 0.0 0.0037 16.8 0.0 2.3 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00298.1 - 2e-05 24.9 0.0 5.4e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00298.1 - 0.00013 22.3 0.0 0.0018 18.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX00298.1 - 0.0018 18.2 0.0 0.0061 16.5 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 EFX00298.1 - 0.0072 15.3 0.0 0.039 12.9 0.0 2.0 2 1 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 EFX00298.1 - 0.018 14.4 0.0 0.043 13.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_25 PF13649.1 EFX00298.1 - 0.02 15.2 0.0 0.11 12.8 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EFX00298.1 - 0.031 13.4 0.0 0.061 12.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 EFX00298.1 - 0.04 13.3 0.0 0.23 10.9 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Ubie_methyltran PF01209.13 EFX00298.1 - 0.08 12.0 0.0 1 8.4 0.0 2.2 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFX00298.1 - 0.092 12.7 0.0 0.88 9.6 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain tRNA-synt_1c PF00749.16 EFX00299.1 - 7.9e-100 333.5 0.1 1e-99 333.1 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EFX00299.1 - 1.2e-36 126.0 0.0 1.9e-36 125.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain MIF4G PF02854.14 EFX00300.1 - 1.6e-18 66.9 0.0 2.2e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.12 EFX00300.1 - 4.6e-18 64.9 0.0 1.6e-17 63.2 0.0 1.9 2 0 0 2 2 2 1 MA3 domain Serglycin PF04360.7 EFX00300.1 - 0.0053 16.4 0.2 0.014 15.1 0.1 1.7 1 0 0 1 1 1 1 Serglycin ADH_N PF08240.7 EFX00301.1 - 4e-30 103.7 0.9 6.9e-30 103.0 0.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX00301.1 - 1.9e-16 59.7 0.1 4.7e-16 58.5 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 EFX00301.1 - 0.00054 19.5 0.0 0.0015 18.1 0.0 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.16 EFX00301.1 - 0.05 13.1 0.1 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Vac_ImportDeg PF09783.4 EFX00302.1 - 2.4e-69 232.3 2.5 3.4e-69 231.8 1.8 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein Gemini_AL1 PF00799.15 EFX00302.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain AAA PF00004.24 EFX00303.1 - 4e-19 69.1 0.0 7e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX00303.1 - 8.1e-05 22.3 0.0 0.0002 21.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EFX00303.1 - 0.00019 22.2 0.0 0.00091 20.0 0.0 2.3 3 0 0 3 3 1 1 AAA domain AAA_16 PF13191.1 EFX00303.1 - 0.00025 21.0 0.0 0.00053 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 EFX00303.1 - 0.00027 20.6 0.2 0.00068 19.3 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain Zot PF05707.7 EFX00303.1 - 0.00027 20.4 0.0 0.016 14.7 0.0 2.6 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_22 PF13401.1 EFX00303.1 - 0.00066 19.8 0.0 0.0033 17.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 EFX00303.1 - 0.0011 18.8 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 EFX00303.1 - 0.0019 18.1 0.0 0.0037 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX00303.1 - 0.0089 16.3 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 EFX00303.1 - 0.013 14.5 0.4 0.046 12.8 0.0 2.0 2 1 0 2 2 2 0 KaiC AAA_25 PF13481.1 EFX00303.1 - 0.015 14.6 0.1 0.096 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 EFX00303.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFX00303.1 - 0.046 12.8 0.0 0.096 11.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 EFX00303.1 - 0.048 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFX00303.1 - 0.05 13.5 0.0 0.21 11.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFX00303.1 - 0.051 12.7 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 EFX00303.1 - 0.099 11.6 0.1 0.21 10.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 EFX00303.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EFX00303.1 - 0.12 11.5 0.1 0.36 10.0 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Biotin_lipoyl PF00364.17 EFX00304.1 - 1.9e-20 72.2 0.1 3.3e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme TPR_8 PF13181.1 EFX00304.1 - 1.7e-07 30.5 0.5 0.0017 17.9 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat E3_binding PF02817.12 EFX00304.1 - 2.6e-06 26.9 0.7 6.4e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 e3 binding domain TPR_14 PF13428.1 EFX00304.1 - 5.1e-06 26.6 16.4 0.32 11.7 0.4 8.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00304.1 - 1.4e-05 24.6 12.2 0.044 13.7 0.2 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00304.1 - 0.00031 21.0 7.9 0.012 15.9 0.3 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat Biotin_lipoyl_2 PF13533.1 EFX00304.1 - 0.00032 20.3 0.0 0.001 18.7 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like TPR_11 PF13414.1 EFX00304.1 - 0.003 17.1 3.6 2.8 7.6 0.1 3.8 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.1 EFX00304.1 - 0.0043 17.1 2.2 0.11 12.7 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFX00304.1 - 0.0067 16.3 10.7 4.1 7.4 0.3 5.6 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFX00304.1 - 0.028 14.0 7.0 0.34 10.6 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX00304.1 - 0.1 13.1 4.1 16 6.2 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat HlyD_2 PF12700.2 EFX00304.1 - 0.45 9.6 0.8 1.8 7.6 0.1 2.2 2 1 0 2 2 2 0 HlyD family secretion protein TPR_7 PF13176.1 EFX00304.1 - 0.91 9.4 3.5 49 4.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFX00304.1 - 4.1 8.2 24.6 0.25 12.0 2.1 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat Glucosamine_iso PF01182.15 EFX00309.1 - 2.9e-54 183.8 0.0 6e-54 182.7 0.0 1.5 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Methyltransf_2 PF00891.13 EFX00311.1 - 5.1e-20 71.7 0.1 4.3e-19 68.6 0.1 1.9 1 1 0 1 1 1 1 O-methyltransferase CheR PF01739.13 EFX00311.1 - 0.053 12.8 0.2 0.081 12.2 0.1 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Peptidase_C14 PF00656.17 EFX00312.1 - 3.9e-44 151.2 0.0 5.8e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Med22 PF06179.7 EFX00312.1 - 2.7e-11 43.4 0.0 4.6e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex TRAM_LAG1_CLN8 PF03798.11 EFX00313.1 - 3.3e-33 114.9 18.0 6e-33 114.0 12.5 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 EFX00313.1 - 2.5e-24 84.5 0.0 8.4e-24 82.8 0.0 2.0 1 0 0 1 1 1 1 TRAM1-like protein dCMP_cyt_deam_1 PF00383.17 EFX00314.1 - 9e-08 31.6 0.0 1.4e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region FAD_binding_4 PF01565.18 EFX00315.1 - 4.7e-17 61.7 3.8 1.1e-16 60.5 2.7 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX00315.1 - 4.6e-08 32.8 0.2 8.3e-08 32.0 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like WD40 PF00400.27 EFX00316.1 - 1.1e-42 142.3 14.3 5.7e-09 35.5 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EFX00316.1 - 2.2e-09 36.9 0.2 4.4e-09 35.9 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX00316.1 - 1.8e-06 27.4 0.0 3.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EFX00316.1 - 2e-05 22.9 0.4 0.078 11.0 0.0 3.4 1 1 2 4 4 4 2 Nucleoporin Nup120/160 PQQ_2 PF13360.1 EFX00316.1 - 0.0053 16.2 0.0 0.023 14.1 0.0 2.0 1 1 0 1 1 1 1 PQQ-like domain Nucleoporin_N PF08801.6 EFX00316.1 - 0.018 13.8 0.3 2.8 6.5 0.0 2.4 2 1 0 2 2 2 0 Nup133 N terminal like DUF3129 PF11327.3 EFX00317.1 - 9e-55 185.3 11.1 9e-55 185.3 7.7 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3129) MYEOV2 PF15004.1 EFX00317.1 - 0.09 13.3 0.0 0.26 11.8 0.0 1.7 2 0 0 2 2 2 0 Myeloma-overexpressed-like I-set PF07679.11 EFX00317.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain Toxin_32 PF08120.6 EFX00317.1 - 0.14 11.7 1.2 2 8.0 0.2 2.8 3 0 0 3 3 3 0 Tamulustoxin family FAT PF02259.18 EFX00319.1 - 2.5e-117 391.7 0.0 6.6e-116 387.1 0.0 2.7 1 1 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 EFX00319.1 - 3.2e-59 200.2 0.6 6.3e-59 199.2 0.4 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.3 EFX00319.1 - 6e-58 195.2 3.3 1.3e-57 194.2 0.4 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) Rapamycin_bind PF08771.6 EFX00319.1 - 1e-42 144.2 1.5 3.4e-42 142.6 0.0 2.8 2 0 0 2 2 2 1 Rapamycin binding domain HEAT_EZ PF13513.1 EFX00319.1 - 7.3e-11 42.2 6.8 8.4e-05 22.9 0.0 9.9 10 1 1 11 11 11 2 HEAT-like repeat FATC PF02260.15 EFX00319.1 - 4.7e-09 35.5 0.2 1.2e-08 34.1 0.1 1.7 1 0 0 1 1 1 1 FATC domain HEAT PF02985.17 EFX00319.1 - 1.7e-07 30.6 20.1 0.017 15.1 0.0 9.9 12 0 0 12 12 12 2 HEAT repeat DUF1772 PF08592.6 EFX00320.1 - 0.022 14.4 1.1 0.022 14.4 0.8 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) DUF3328 PF11807.3 EFX00321.1 - 6.1e-48 163.3 0.1 7.2e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) COG2 PF06148.6 EFX00322.1 - 2.5e-21 75.9 0.5 6.8e-21 74.5 0.3 1.7 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.4 EFX00322.1 - 0.00031 20.7 0.0 0.00056 19.8 0.0 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Vps51 PF08700.6 EFX00322.1 - 0.00099 18.9 0.2 0.0043 16.8 0.1 2.2 1 1 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.7 EFX00322.1 - 0.02 13.3 0.3 0.033 12.6 0.2 1.3 1 0 0 1 1 1 0 Dor1-like family DUF2450 PF10475.4 EFX00322.1 - 0.18 10.6 0.0 0.28 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Zn_clus PF00172.13 EFX00323.1 - 8.7e-09 35.1 9.7 1.5e-08 34.4 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFX00323.1 - 5.1e-08 31.9 0.2 7.8e-08 31.3 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phosphonate-bd PF12974.2 EFX00324.1 - 5e-05 22.7 0.0 9.2e-05 21.9 0.0 1.4 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.15 EFX00324.1 - 8.8e-05 21.8 0.0 0.00038 19.7 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.6 EFX00324.1 - 0.0002 21.0 0.0 0.001 18.7 0.0 2.1 2 1 0 2 2 2 1 NMT1/THI5 like DUF3834 PF12916.2 EFX00324.1 - 0.029 13.3 0.0 0.4 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) DUF2341 PF10102.4 EFX00324.1 - 0.15 12.2 1.1 0.75 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2341) PAT1 PF09770.4 EFX00325.1 - 7.9 4.5 17.2 9.6 4.3 11.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Mito_carr PF00153.22 EFX00327.1 - 7.7e-16 57.5 0.4 0.00043 19.9 0.0 5.3 4 1 0 4 4 4 4 Mitochondrial carrier protein GIDA PF01134.17 EFX00328.1 - 5.4e-149 496.3 0.0 6.9e-149 495.9 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Tyr-DNA_phospho PF06087.7 EFX00328.1 - 2.2e-78 263.8 0.0 2.9e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase GIDA_assoc_3 PF13932.1 EFX00328.1 - 2.2e-12 46.8 0.1 2.2e-11 43.6 0.0 2.7 2 0 0 2 2 2 1 GidA associated domain 3 FAD_oxidored PF12831.2 EFX00328.1 - 2e-06 27.1 2.0 3.4e-06 26.4 1.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX00328.1 - 1.3e-05 25.2 0.6 3.6e-05 23.7 0.4 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX00328.1 - 0.0012 17.7 2.5 0.0012 17.7 1.7 1.9 2 0 0 2 2 2 1 FAD binding domain PLDc_2 PF13091.1 EFX00328.1 - 0.014 15.1 0.0 0.049 13.3 0.0 1.9 2 0 0 2 2 2 0 PLD-like domain HI0933_like PF03486.9 EFX00328.1 - 0.054 11.9 1.5 0.23 9.8 0.5 2.1 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.1 EFX00328.1 - 0.09 13.0 0.2 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 EFX00328.1 - 0.18 11.3 2.1 0.17 11.4 0.1 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PAP_assoc PF03828.14 EFX00330.1 - 1.9e-14 53.3 0.1 3.8e-14 52.3 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EFX00330.1 - 9.5e-07 29.0 0.0 1.8e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain APC_CDC26 PF10471.4 EFX00330.1 - 0.033 14.9 0.2 0.12 13.1 0.2 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 Serglycin PF04360.7 EFX00331.1 - 0.0016 18.1 2.9 0.0035 17.0 2.0 1.5 1 0 0 1 1 1 1 Serglycin Synaptobrevin PF00957.16 EFX00331.1 - 0.01 15.3 0.7 0.021 14.3 0.5 1.4 1 0 0 1 1 1 0 Synaptobrevin CAF1A PF12253.3 EFX00331.1 - 7.2 6.7 13.1 0.58 10.3 1.0 2.4 1 1 1 2 2 2 0 Chromatin assembly factor 1 subunit A His_Phos_1 PF00300.17 EFX00333.1 - 7.6e-22 78.0 0.0 1.3e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PDEase_II PF02112.10 EFX00334.1 - 9.4e-56 189.1 0.0 6.5e-23 81.1 0.0 3.2 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.2 EFX00334.1 - 0.00067 19.2 0.1 0.54 9.7 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain HET PF06985.6 EFX00335.1 - 5.1e-13 49.3 0.2 9.2e-12 45.3 0.0 2.2 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) ABC_tran PF00005.22 EFX00337.1 - 1.1e-27 96.9 0.0 1.6e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 EFX00337.1 - 1.1e-24 86.7 29.1 1.9e-24 85.9 20.2 1.3 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.1 EFX00337.1 - 2.6e-07 30.9 0.1 0.022 14.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 EFX00337.1 - 6.1e-07 28.8 0.0 2.3e-06 26.9 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFX00337.1 - 2.6e-06 27.5 0.1 3.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 EFX00337.1 - 2.7e-06 26.9 0.1 5.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFX00337.1 - 0.00019 20.6 0.1 0.0003 19.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 EFX00337.1 - 0.0002 20.8 0.1 0.00042 19.7 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 EFX00337.1 - 0.00052 20.1 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX00337.1 - 0.00057 19.5 0.3 0.0012 18.6 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 EFX00337.1 - 0.00078 20.2 0.1 0.0016 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EFX00337.1 - 0.00096 18.6 0.1 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain T2SE PF00437.15 EFX00337.1 - 0.0014 17.6 0.3 0.0023 16.8 0.2 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein IstB_IS21 PF01695.12 EFX00337.1 - 0.0014 18.0 0.1 0.0028 17.1 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.1 EFX00337.1 - 0.0019 18.1 0.1 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 EFX00337.1 - 0.0034 17.3 0.0 0.0083 16.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase NTPase_1 PF03266.10 EFX00337.1 - 0.0035 17.0 0.1 0.0093 15.6 0.0 1.7 2 0 0 2 2 2 1 NTPase AAA_15 PF13175.1 EFX00337.1 - 0.0046 16.0 0.0 1.6 7.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 EFX00337.1 - 0.0074 15.9 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.1 EFX00337.1 - 0.0074 15.8 0.4 0.012 15.1 0.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX00337.1 - 0.008 16.4 0.1 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.14 EFX00337.1 - 0.0084 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EFX00337.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFX00337.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 EFX00337.1 - 0.015 15.5 0.1 0.08 13.1 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 EFX00337.1 - 0.017 15.4 0.2 0.029 14.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EFX00337.1 - 0.018 14.6 0.3 0.035 13.7 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 EFX00337.1 - 0.019 14.4 0.2 0.032 13.6 0.2 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_5 PF07728.9 EFX00337.1 - 0.035 13.8 0.0 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 EFX00337.1 - 0.036 13.9 0.0 0.25 11.3 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.17 EFX00337.1 - 0.037 14.2 0.0 0.078 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase SRP54 PF00448.17 EFX00337.1 - 0.069 12.5 0.1 0.14 11.5 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.1 EFX00337.1 - 0.084 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFX00337.1 - 0.089 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase Septin PF00735.13 EFX00337.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_24 PF13479.1 EFX00337.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain NicO PF03824.11 EFX00338.1 - 2.5e-61 207.5 7.5 2.5e-61 207.5 5.2 1.5 2 1 0 2 2 2 1 High-affinity nickel-transport protein RIX1 PF08167.7 EFX00339.1 - 6.7e-45 152.7 0.2 1.6e-44 151.4 0.0 1.8 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis GAGA_bind PF06217.7 EFX00341.1 - 0.47 10.3 8.5 0.75 9.7 5.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family BTV_NS2 PF04514.7 EFX00341.1 - 2.9 6.6 18.5 4 6.2 12.8 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Paramyxo_ncap PF00973.14 EFX00341.1 - 3.7 6.1 7.6 5 5.7 5.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4192 PF13830.1 EFX00341.1 - 6.7 6.2 15.3 15 5.1 10.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4192) DUF1510 PF07423.6 EFX00341.1 - 8.6 5.6 20.9 14 4.9 14.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAPP PF04051.11 EFX00342.1 - 1.6e-43 147.8 0.0 2.7e-43 147.0 0.0 1.4 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component YadA_anchor PF03895.10 EFX00342.1 - 2.6 8.1 12.9 5.2 7.1 8.9 1.4 1 0 0 1 1 1 0 YadA-like C-terminal region Mtc PF03820.12 EFX00343.1 - 2.7e-106 354.7 0.0 2.9e-106 354.5 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier V-SNARE PF05008.10 EFX00344.1 - 0.00033 20.7 3.9 0.00033 20.7 2.7 2.3 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Seryl_tRNA_N PF02403.17 EFX00344.1 - 0.15 12.1 21.1 0.24 11.4 2.1 2.7 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Bacillus_HBL PF05791.6 EFX00344.1 - 1.5 8.1 9.5 3.7 6.8 4.1 2.6 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) GAS PF13851.1 EFX00344.1 - 2.9 7.0 16.8 0.46 9.6 6.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 EFX00344.1 - 5.2 6.6 19.2 5.8 6.4 7.9 2.4 1 1 1 2 2 2 0 IncA protein Abhydrolase_6 PF12697.2 EFX00345.1 - 1.7e-18 67.3 1.9 6.7e-18 65.3 1.3 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX00345.1 - 1.7e-08 34.3 0.0 0.005 16.6 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX00345.1 - 1.2e-05 24.9 0.0 2.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Mito_carr PF00153.22 EFX00346.1 - 4e-53 177.1 4.0 1e-18 66.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L29e PF01779.12 EFX00346.1 - 3.5e-21 74.7 9.3 7.5e-21 73.7 6.4 1.6 1 0 0 1 1 1 1 Ribosomal L29e protein family Hexapep_2 PF14602.1 EFX00347.1 - 1.2e-11 43.9 12.6 5.1e-09 35.5 3.6 3.4 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.19 EFX00347.1 - 1.3e-11 43.4 11.0 2.5e-09 36.1 3.5 3.5 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.3 EFX00347.1 - 1.2e-07 31.6 0.1 3.4e-07 30.1 0.1 1.8 1 0 0 1 1 1 1 Maltose acetyltransferase Metallophos PF00149.23 EFX00348.1 - 1.4e-44 151.8 0.2 1.7e-44 151.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_M18 PF02127.10 EFX00349.1 - 2.6e-162 540.2 0.0 3.1e-162 540.0 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 EFX00349.1 - 2.5e-05 23.2 0.0 0.00026 19.8 0.0 2.4 2 1 1 3 3 3 1 M42 glutamyl aminopeptidase Ribosomal_L23eN PF03939.8 EFX00350.1 - 1.6e-18 66.4 11.8 1.6e-18 66.4 8.2 2.1 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.15 EFX00350.1 - 6.5e-18 64.4 1.9 1.3e-17 63.5 1.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 SRP54 PF00448.17 EFX00352.1 - 4.2e-77 258.0 2.3 9.7e-77 256.8 1.3 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 EFX00352.1 - 5e-25 87.7 5.3 5e-25 87.7 3.7 4.3 2 1 2 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.14 EFX00352.1 - 3.7e-15 55.7 0.4 1e-14 54.3 0.3 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 EFX00352.1 - 5.7e-09 35.6 0.2 1.6e-08 34.2 0.1 1.8 2 0 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EFX00352.1 - 1.6e-07 31.3 0.0 3.7e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX00352.1 - 0.00014 22.6 0.0 0.00038 21.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain CbiA PF01656.18 EFX00352.1 - 0.00022 20.6 0.1 0.00077 18.9 0.1 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 EFX00352.1 - 0.00027 20.6 0.0 0.00071 19.3 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.1 EFX00352.1 - 0.00097 19.0 0.0 0.64 9.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.15 EFX00352.1 - 0.0025 17.4 0.0 0.0055 16.3 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.1 EFX00352.1 - 0.004 17.2 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 EFX00352.1 - 0.0043 16.4 0.1 0.027 13.8 0.0 2.3 2 0 0 2 2 2 1 Thymidylate kinase AAA_16 PF13191.1 EFX00352.1 - 0.0043 17.0 0.1 0.014 15.4 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain ATP_bind_1 PF03029.12 EFX00352.1 - 0.0093 15.5 0.2 0.044 13.3 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.7 EFX00352.1 - 0.01 14.9 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ArgK PF03308.11 EFX00352.1 - 0.012 14.4 4.5 0.014 14.1 0.9 2.5 2 1 0 2 2 2 0 ArgK protein SRPRB PF09439.5 EFX00352.1 - 0.015 14.5 0.8 4.7 6.3 0.6 3.2 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_10 PF12846.2 EFX00352.1 - 0.023 14.1 0.1 0.041 13.3 0.1 1.5 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.24 EFX00352.1 - 0.034 14.3 0.1 0.14 12.3 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EFX00352.1 - 0.045 13.7 0.0 0.097 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFX00352.1 - 0.06 13.6 0.0 0.17 12.2 0.0 1.9 2 1 0 2 2 1 0 AAA domain NTPase_1 PF03266.10 EFX00352.1 - 0.11 12.2 0.9 3 7.5 0.6 2.5 1 1 0 1 1 1 0 NTPase DUF3052 PF11253.3 EFX00352.1 - 0.13 11.8 0.5 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3052) DUF4630 PF15443.1 EFX00354.1 - 0.038 13.8 0.0 0.078 12.7 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4630) Pyridox_ox_2 PF12900.2 EFX00355.1 - 1.6e-29 102.6 0.8 2.4e-29 101.9 0.3 1.5 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Glyco_hydro_3 PF00933.16 EFX00356.1 - 2.5e-79 266.3 0.0 3.8e-79 265.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX00356.1 - 7.9e-63 212.0 0.0 1.7e-62 210.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX00356.1 - 7.3e-16 57.8 0.0 1.6e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EFX00356.1 - 3.6e-10 39.6 0.0 9e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 PA14 domain TPR_12 PF13424.1 EFX00356.1 - 1.3e-09 37.8 6.6 0.0002 21.2 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat NB-ARC PF00931.17 EFX00356.1 - 1.1e-05 24.4 0.0 1.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain Lipase_GDSL_2 PF13472.1 EFX00356.1 - 0.0022 18.1 0.4 0.0082 16.2 0.1 2.2 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family TPR_1 PF00515.23 EFX00356.1 - 0.0027 17.2 0.2 0.95 9.1 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00356.1 - 0.013 15.3 3.7 1.6 8.8 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFX00356.1 - 0.028 14.0 0.3 0.96 9.1 0.0 3.3 2 2 0 2 2 2 0 TPR repeat Paf67 PF10255.4 EFX00356.1 - 0.88 8.3 0.3 1.5 7.6 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 zf-rbx1 PF12678.2 EFX00358.1 - 4.2e-35 119.6 13.5 5.3e-35 119.3 9.4 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EFX00358.1 - 4.3e-17 61.7 9.8 5.6e-17 61.3 6.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 EFX00358.1 - 3.7e-07 29.8 11.9 3.3e-06 26.8 8.3 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFX00358.1 - 0.0015 18.1 11.6 0.026 14.1 8.0 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX00358.1 - 0.0039 16.8 9.7 0.4 10.3 6.8 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX00358.1 - 0.044 13.8 12.6 0.048 13.6 5.4 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.1 EFX00358.1 - 0.42 10.6 9.0 1.3 9.0 6.2 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_5 PF14634.1 EFX00358.1 - 0.67 9.7 12.1 6.7 6.5 8.4 2.4 1 1 0 1 1 1 0 zinc-RING finger domain FANCL_C PF11793.3 EFX00358.1 - 0.7 9.9 9.2 3.6 7.6 6.6 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.1 EFX00358.1 - 1.4 8.6 6.7 34 4.2 4.7 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-HC5HC2H PF13771.1 EFX00358.1 - 2.7 8.1 10.9 1.4e+02 2.7 7.3 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain Ribonuc_P_40 PF08584.6 EFX00359.1 - 5.2e-60 202.8 0.0 7.1e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit EB1 PF03271.12 EFX00360.1 - 5.5e-17 61.5 1.6 1.1e-16 60.6 1.1 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 EFX00360.1 - 6.9e-07 29.2 0.8 1.2e-06 28.4 0.6 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Phi-29_GP3 PF05435.6 EFX00360.1 - 0.028 13.6 0.0 0.052 12.7 0.0 1.4 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 Syja_N PF02383.13 EFX00360.1 - 0.086 11.5 0.0 0.096 11.4 0.0 1.1 1 0 0 1 1 1 0 SacI homology domain p450 PF00067.17 EFX00361.1 - 3.7e-64 216.9 0.0 5e-64 216.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PEPCK_ATP PF01293.15 EFX00362.1 - 5.4e-212 704.4 0.0 6.2e-212 704.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_29 PF13555.1 EFX00362.1 - 0.038 13.5 0.0 0.092 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX00362.1 - 0.045 14.0 0.0 9.8 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 EFX00362.1 - 0.11 12.4 0.1 0.23 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EFX00362.1 - 0.2 11.6 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain SBDS_C PF09377.5 EFX00364.1 - 1.1e-46 157.5 0.0 1.9e-46 156.8 0.0 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.13 EFX00364.1 - 1.5e-27 95.1 0.1 2.6e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Ribosomal_60s PF00428.14 EFX00364.1 - 0.021 15.1 6.2 0.021 15.1 4.3 3.6 2 1 0 2 2 2 0 60s Acidic ribosomal protein Glyco_hydro_72 PF03198.9 EFX00365.1 - 2.1e-121 404.7 4.3 3.5e-121 404.0 3.0 1.3 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 EFX00365.1 - 8.2e-20 71.0 5.8 2.6e-19 69.4 4.0 1.9 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.12 EFX00365.1 - 0.00012 21.0 0.0 0.0002 20.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain zf-H2C2_2 PF13465.1 EFX00366.1 - 2e-14 53.0 8.9 3.1e-08 33.5 0.4 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EFX00366.1 - 4.8e-11 42.3 13.2 8.2e-06 25.8 1.6 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX00366.1 - 2e-10 40.2 14.0 3.1e-05 23.9 1.8 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFX00366.1 - 1.6e-05 24.8 4.4 0.071 13.2 0.2 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX00366.1 - 0.00049 20.1 3.3 0.0095 16.1 0.2 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-Di19 PF05605.7 EFX00366.1 - 0.082 13.0 1.9 0.16 12.0 1.4 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Flu_M1 PF00598.14 EFX00366.1 - 0.24 10.7 0.0 0.41 10.0 0.0 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M1) LIM PF00412.17 EFX00366.1 - 1.8 8.6 4.7 12 6.0 1.5 2.2 1 1 1 2 2 2 0 LIM domain zf-C2H2_6 PF13912.1 EFX00366.1 - 9.4 6.3 12.5 4.5 7.3 0.4 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger Nol1_Nop2_Fmu PF01189.12 EFX00368.1 - 4.2e-15 55.8 0.0 3.1e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 NOL1/NOP2/sun family Sec63 PF02889.11 EFX00369.1 - 9.9e-44 149.8 0.0 2.2e-43 148.6 0.0 1.5 1 1 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.26 EFX00369.1 - 6.2e-16 57.8 0.8 1.3e-15 56.8 0.6 1.6 1 0 0 1 1 1 1 DnaJ domain Acyltransferase PF01553.16 EFX00370.1 - 9.6e-33 112.4 0.0 1.4e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Peptidase_M24 PF00557.19 EFX00371.1 - 3.3e-10 39.8 0.1 4.4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 CUE PF02845.11 EFX00372.1 - 2.7e-05 23.5 0.0 4.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 CUE domain Methyltransf_23 PF13489.1 EFX00374.1 - 1.8e-18 66.7 0.0 2.9e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00374.1 - 4.5e-15 55.9 0.0 7.9e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00374.1 - 1e-08 34.8 0.0 1.7e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00374.1 - 4.2e-08 33.7 0.0 3.9e-07 30.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00374.1 - 7e-08 32.8 0.0 1.8e-07 31.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX00374.1 - 1.5e-06 28.5 0.0 2.9e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX00374.1 - 1.2e-05 24.5 0.0 0.00013 21.1 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EFX00374.1 - 0.00016 20.7 0.0 0.0018 17.3 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX00374.1 - 0.0003 20.8 0.0 0.0011 19.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX00374.1 - 0.0017 17.7 0.0 0.021 14.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_8 PF05148.10 EFX00374.1 - 0.0019 17.8 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_16 PF10294.4 EFX00374.1 - 0.0049 16.3 0.0 0.0084 15.5 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 EFX00374.1 - 0.012 14.7 0.0 0.026 13.6 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 EFX00374.1 - 0.033 13.2 0.0 0.29 10.1 0.0 2.0 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF938 PF06080.7 EFX00374.1 - 0.064 12.7 0.0 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF938) FtsJ PF01728.14 EFX00374.1 - 0.095 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Flavokinase PF01687.12 EFX00375.1 - 2.5e-10 40.3 0.0 4e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase E1-E2_ATPase PF00122.15 EFX00376.1 - 3e-20 72.2 0.0 3e-20 72.2 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 EFX00376.1 - 1.1e-16 61.8 0.2 1.7e-11 44.9 0.1 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFX00376.1 - 9.6e-14 51.9 0.0 4e-09 36.9 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX00376.1 - 5.5e-11 42.2 0.0 2.4e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFX00376.1 - 0.00026 20.6 0.0 0.00077 19.1 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX00376.1 - 0.016 15.4 0.1 0.041 14.1 0.1 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase BP28CT PF08146.7 EFX00377.1 - 5.6e-27 94.3 0.0 2.1e-26 92.5 0.0 2.1 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 EFX00377.1 - 3.5e-25 88.2 8.8 3.9e-24 84.9 0.4 4.2 3 0 0 3 3 3 2 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.17 EFX00377.1 - 0.0091 16.0 17.4 0.012 15.6 0.0 6.7 7 0 0 7 7 7 2 HEAT repeat DIOX_N PF14226.1 EFX00378.1 - 8.8e-25 87.4 0.0 1.3e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX00378.1 - 6.5e-20 71.2 0.0 1e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF898 PF05987.8 EFX00380.1 - 0.032 13.1 7.5 0.043 12.6 5.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) RNA_pol_Rpb6 PF01192.17 EFX00381.1 - 1.4e-21 75.9 0.1 2.3e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-H2C2_2 PF13465.1 EFX00383.1 - 1.9e-05 24.7 4.3 1.9e-05 24.7 3.0 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.21 EFX00383.1 - 2.1e-05 24.5 3.7 2.1e-05 24.5 2.5 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX00383.1 - 0.00032 20.8 0.9 0.00032 20.8 0.6 3.9 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFX00383.1 - 0.0004 20.4 0.8 0.0004 20.4 0.6 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFX00383.1 - 0.1 12.5 2.8 0.37 10.7 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-TRAF PF02176.13 EFX00383.1 - 0.56 10.6 6.8 0.18 12.2 2.4 1.9 2 0 0 2 2 2 0 TRAF-type zinc finger Fungal_trans PF04082.13 EFX00384.1 - 1.3e-14 53.7 0.3 2.7e-14 52.6 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX00384.1 - 6.9e-08 32.2 12.9 1.3e-07 31.3 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_1 PF00583.19 EFX00386.1 - 0.002 18.1 0.0 0.0051 16.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX00386.1 - 0.023 14.8 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFX00386.1 - 0.027 14.6 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFX00386.1 - 0.036 14.0 0.0 0.3 11.0 0.0 2.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Tox-HNH-HHH PF15637.1 EFX00386.1 - 0.058 13.1 0.6 0.23 11.2 0.1 2.2 3 0 0 3 3 3 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif LMBR1 PF04791.11 EFX00387.1 - 1.9e-27 96.0 7.7 7.2e-27 94.0 5.3 1.7 1 1 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_S10 PF00338.17 EFX00388.1 - 1.9e-27 94.9 0.3 2.3e-27 94.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fungal_trans PF04082.13 EFX00389.1 - 1.5e-05 24.0 0.0 2.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HAUS5 PF14817.1 EFX00389.1 - 0.14 10.7 0.1 0.19 10.2 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 ARD PF03079.9 EFX00391.1 - 1.6e-43 148.3 0.0 2e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 EFX00391.1 - 5.7e-09 35.3 0.1 9e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 EFX00391.1 - 3.1e-07 30.1 0.0 4.4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain DUF1498 PF07385.7 EFX00391.1 - 0.032 13.3 0.0 0.056 12.5 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1498) Cupin_1 PF00190.17 EFX00391.1 - 0.049 13.0 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Cupin GSH_synthase PF03199.10 EFX00391.1 - 0.054 13.5 0.0 0.11 12.6 0.0 1.5 1 1 0 1 1 1 0 Eukaryotic glutathione synthase Ank PF00023.25 EFX00392.1 - 1.8e-29 100.0 1.9 6.8e-10 38.2 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.2 EFX00392.1 - 1.1e-27 96.1 0.3 3.2e-17 62.6 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX00392.1 - 2.6e-23 81.9 7.5 1.3e-10 41.4 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX00392.1 - 5.2e-22 75.7 2.7 1.1e-07 31.3 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 EFX00392.1 - 7.2e-22 76.9 6.9 1.2e-11 44.4 0.4 3.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) DUF3321 PF11968.3 EFX00393.1 - 1.2e-83 280.0 0.0 1.6e-83 279.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 EFX00393.1 - 1.1e-06 28.5 0.0 1.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CBFD_NFYB_HMF PF00808.18 EFX00394.1 - 1.4e-19 69.9 0.6 2.2e-19 69.2 0.4 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFX00394.1 - 2.5e-11 43.5 0.1 3.9e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 EFX00394.1 - 0.022 14.5 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF2040 PF09745.4 EFX00395.1 - 2.6e-34 117.7 16.5 2.6e-34 117.7 11.5 4.2 3 1 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) AAA_23 PF13476.1 EFX00395.1 - 3.5 7.9 17.5 0.46 10.7 4.7 2.3 2 0 0 2 2 2 0 AAA domain Fn3_assoc PF13287.1 EFX00396.1 - 0.16 12.0 1.2 0.79 9.8 0.0 2.3 2 0 0 2 2 2 0 Fn3 associated CAF-1_p150 PF11600.3 EFX00396.1 - 0.93 8.8 15.1 0.051 12.9 5.6 2.0 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PAT1 PF09770.4 EFX00396.1 - 2.4 6.2 6.1 3.2 5.8 4.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GCV_H PF01597.14 EFX00397.1 - 6.1e-34 116.3 0.5 7.9e-34 115.9 0.4 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 EFX00397.1 - 0.02 14.5 0.1 0.036 13.6 0.1 1.4 1 0 0 1 1 1 0 Biotin-requiring enzyme RnfC_N PF13375.1 EFX00397.1 - 0.064 12.9 0.2 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Aminotran_5 PF00266.14 EFX00398.1 - 1.2e-10 40.6 0.0 1.9e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Pyridoxal_deC PF00282.14 EFX00398.1 - 0.13 10.7 0.0 0.2 10.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain MrpF_PhaF PF04066.8 EFX00399.1 - 0.11 12.7 0.0 0.11 12.7 0.0 2.6 3 0 0 3 3 3 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) Adaptin_N PF01602.15 EFX00401.1 - 1.1e-92 311.1 3.2 1.7e-92 310.4 2.2 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.7 EFX00401.1 - 2e-62 209.0 0.5 4e-62 208.0 0.3 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.1 EFX00401.1 - 4.4e-61 204.3 0.0 1.2e-60 202.8 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform HEAT_2 PF13646.1 EFX00401.1 - 2.3e-10 40.6 5.2 7.1e-05 23.0 0.0 4.4 1 1 2 3 3 3 3 HEAT repeats Cnd1 PF12717.2 EFX00401.1 - 1.4e-05 25.0 2.4 0.011 15.5 0.0 3.8 2 2 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 EFX00401.1 - 0.00036 20.3 0.7 0.22 11.7 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.1 EFX00401.1 - 0.0013 19.1 1.1 5 7.7 0.0 3.9 3 0 0 3 3 3 2 HEAT-like repeat Abhydrolase_3 PF07859.8 EFX00403.1 - 2.2e-54 184.2 0.1 3.2e-54 183.6 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EFX00403.1 - 6.2e-09 35.1 0.0 1.9e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EFX00403.1 - 0.00091 18.9 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 EFX00403.1 - 0.013 14.7 0.1 0.025 13.8 0.1 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Peptidase_S9 PF00326.16 EFX00403.1 - 0.014 14.5 0.1 0.061 12.5 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 EFX00403.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Pkinase PF00069.20 EFX00404.1 - 4e-49 167.1 0.0 5.7e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00404.1 - 1.2e-22 80.2 0.0 2.8e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EFX00404.1 - 0.026 13.3 0.1 0.038 12.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.1 EFX00404.1 - 0.039 12.9 0.0 0.065 12.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 EFX00404.1 - 0.16 11.3 0.0 0.35 10.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family DUF2575 PF10837.3 EFX00405.1 - 0.057 13.5 0.2 1.2 9.2 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2575) MFS_1 PF07690.11 EFX00406.1 - 2.1e-21 76.0 38.6 5.6e-21 74.6 20.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3237 PF11578.3 EFX00408.1 - 7.3e-22 77.2 0.4 4.1e-17 61.8 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3237) Aldo_ket_red PF00248.16 EFX00409.1 - 1.7e-43 148.4 0.0 1.8e-41 141.8 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.11 EFX00410.1 - 4.2e-26 91.4 48.2 7.7e-26 90.6 28.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Thioesterase PF00975.15 EFX00411.1 - 6.4e-18 65.8 0.1 2.8e-17 63.7 0.0 1.9 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 EFX00411.1 - 2.2e-09 37.5 4.2 4.5e-09 36.5 2.9 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX00411.1 - 0.00019 21.2 0.0 0.00028 20.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFX00411.1 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 EFX00411.1 - 0.016 14.7 0.2 0.024 14.1 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 EFX00411.1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Adap_comp_sub PF00928.16 EFX00412.1 - 1e-85 287.0 0.0 1.3e-85 286.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EFX00412.1 - 6e-05 22.7 0.1 0.00011 21.9 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1081 PF06448.6 EFX00412.1 - 0.054 13.3 0.3 0.13 12.1 0.1 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1081) E1-E2_ATPase PF00122.15 EFX00413.1 - 8.5e-28 96.9 0.1 1.6e-27 96.0 0.1 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EFX00413.1 - 3.4e-24 86.4 0.3 8.8e-24 85.1 0.2 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFX00413.1 - 2.2e-09 37.7 0.0 7.7e-09 35.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 EFX00413.1 - 5.8e-09 35.9 0.0 1.5e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Heavy-metal-associated domain HLH PF00010.21 EFX00414.1 - 5.6e-11 41.9 0.0 9.6e-11 41.2 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PCI PF01399.22 EFX00415.1 - 7.9e-08 32.5 2.2 1.8e-07 31.4 0.1 2.7 2 1 0 2 2 2 1 PCI domain CoA_transf_3 PF02515.12 EFX00417.1 - 6.1e-33 113.6 0.1 1e-32 112.9 0.1 1.4 1 0 0 1 1 1 1 CoA-transferase family III Peptidase_M16_C PF05193.16 EFX00418.1 - 3.5e-33 114.8 0.0 2.5e-17 63.1 0.0 3.3 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFX00418.1 - 1.8e-32 112.1 0.0 5.1e-32 110.6 0.0 1.9 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) CAS_CSE1 PF03378.10 EFX00418.1 - 0.043 12.1 0.9 0.099 10.9 0.6 1.5 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus Xpo1 PF08389.7 EFX00419.1 - 0.24 11.3 7.2 0.26 11.2 0.0 4.2 5 1 0 5 5 5 0 Exportin 1-like protein zf-C2H2 PF00096.21 EFX00421.1 - 6.1 7.3 8.5 10 6.7 1.0 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX00421.1 - 8.6 6.9 7.3 12 6.5 0.8 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger RdRP PF05183.7 EFX00422.1 - 3.4e-106 356.2 0.0 4.8e-106 355.7 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase LrgB PF04172.11 EFX00423.1 - 1.1e-12 47.5 16.8 1.7e-07 30.5 4.9 2.3 2 0 0 2 2 2 2 LrgB-like family PHD PF00628.24 EFX00425.1 - 1.2e-16 60.1 17.6 2.2e-10 40.0 5.6 2.4 2 0 0 2 2 2 2 PHD-finger Orbi_VP6 PF01516.11 EFX00425.1 - 0.0024 17.0 12.0 0.0024 17.0 8.3 3.8 3 0 0 3 3 3 1 Orbivirus helicase VP6 zf-PHD-like PF15446.1 EFX00425.1 - 0.0058 15.9 6.3 0.25 10.6 2.0 2.7 2 0 0 2 2 2 2 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.1 EFX00425.1 - 0.38 10.1 7.2 8 5.8 2.1 2.7 2 0 0 2 2 2 0 PHD-finger Prok-RING_1 PF14446.1 EFX00425.1 - 5.5 6.8 12.3 5.2 6.8 0.7 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DUF4211 PF13926.1 EFX00426.1 - 1e-31 109.4 0.0 3.9e-31 107.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) Topoisom_bac PF01131.15 EFX00429.1 - 5.7e-70 236.1 0.0 2.6e-63 214.2 0.0 3.0 2 1 0 2 2 2 2 DNA topoisomerase Toprim PF01751.17 EFX00429.1 - 2.1e-17 62.9 0.0 6.2e-17 61.4 0.0 1.8 2 0 0 2 2 2 1 Toprim domain Annexin PF00191.15 EFX00430.1 - 2.5e-70 232.3 2.2 3e-20 71.8 0.0 4.5 4 1 0 4 4 4 4 Annexin Acetyltransf_11 PF13720.1 EFX00430.1 - 0.05 13.8 2.4 3.1 8.0 0.0 3.5 4 0 0 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TSLP PF15216.1 EFX00430.1 - 0.21 11.3 0.0 27 4.5 0.0 3.0 3 0 0 3 3 3 0 Thymic stromal lymphopoietin RIO1 PF01163.17 EFX00431.1 - 2.6e-60 203.0 2.3 1.3e-58 197.5 0.0 2.5 2 1 0 2 2 2 1 RIO1 family APH PF01636.18 EFX00431.1 - 0.00024 20.8 0.9 0.00068 19.4 0.2 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFX00431.1 - 0.0092 15.0 0.8 0.24 10.4 0.0 2.5 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2388 PF09498.5 EFX00431.1 - 0.053 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) Nop14 PF04147.7 EFX00431.1 - 0.2 9.5 13.6 0.28 9.0 9.4 1.1 1 0 0 1 1 1 0 Nop14-like family TauD PF02668.11 EFX00433.1 - 4e-26 92.2 0.0 6.9e-26 91.4 0.0 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 EFX00433.1 - 0.00085 18.3 0.0 0.0013 17.7 0.0 1.2 1 0 0 1 1 1 1 CsiD 2OG-FeII_Oxy_3 PF13640.1 EFX00433.1 - 0.045 14.2 0.1 2.7 8.5 0.0 2.4 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Tfb2 PF03849.9 EFX00435.1 - 3.9e-127 423.8 0.0 1.7e-125 418.4 0.0 2.0 2 0 0 2 2 2 2 Transcription factor Tfb2 Helicase_C_3 PF13625.1 EFX00435.1 - 0.00026 20.7 0.2 0.0011 18.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Peptidase_M24 PF00557.19 EFX00436.1 - 6.8e-57 192.3 0.0 9.7e-57 191.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EFX00436.1 - 2.9e-24 84.9 0.0 4.9e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain SAM_decarbox PF01536.11 EFX00437.1 - 6.8e-62 209.0 0.7 1e-22 80.2 0.6 4.9 2 1 1 3 3 3 3 Adenosylmethionine decarboxylase DbpA PF03880.10 EFX00439.1 - 0.056 13.1 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain RRM_5 PF13893.1 EFX00439.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-Q PF13094.1 EFX00440.1 - 0.0002 21.4 0.2 0.00044 20.3 0.2 1.6 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit ImcF-related_N PF14331.1 EFX00440.1 - 0.14 11.0 0.3 0.22 10.3 0.2 1.2 1 0 0 1 1 1 0 ImcF-related N-terminal domain tRNA-synt_1d PF00750.14 EFX00441.1 - 1.8e-51 175.0 0.0 3.4e-51 174.1 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 EFX00441.1 - 7.8e-14 51.6 0.0 1.4e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain Peptidase_S9 PF00326.16 EFX00442.1 - 5.4e-24 84.5 0.3 6.7e-24 84.2 0.2 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFX00442.1 - 4.2e-05 23.3 0.1 5.2e-05 23.0 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2920 PF11144.3 EFX00442.1 - 0.069 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) TMA7 PF09072.5 EFX00444.1 - 9.7e-24 83.6 20.7 1.1e-23 83.4 14.4 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 LptE PF04390.7 EFX00444.1 - 0.1 12.3 0.2 0.13 12.0 0.2 1.1 1 0 0 1 1 1 0 Lipopolysaccharide-assembly DUF2423 PF10338.4 EFX00445.1 - 5.7e-17 61.4 3.9 1.1e-16 60.4 2.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Phosphodiest PF01663.17 EFX00445.1 - 2.8e-14 53.2 2.8 7.4e-13 48.5 2.0 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFX00445.1 - 0.0015 17.7 0.0 0.028 13.5 0.0 2.3 2 1 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.13 EFX00445.1 - 0.011 15.0 0.1 0.028 13.8 0.0 1.6 1 1 0 1 1 1 0 Metalloenzyme superfamily Peptidase_M18 PF02127.10 EFX00447.1 - 6.7e-122 407.0 0.0 8e-122 406.8 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) tRNA_synt_2f PF02092.12 EFX00447.1 - 0.3 9.5 0.0 0.44 9.0 0.0 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit Sen15 PF09631.5 EFX00448.1 - 5.7e-23 81.0 0.0 2.1e-22 79.2 0.0 1.8 1 1 0 1 1 1 1 Sen15 protein Methyltransf_2 PF00891.13 EFX00449.1 - 2.5e-29 102.1 0.0 1.1e-28 100.1 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase MarR_2 PF12802.2 EFX00449.1 - 0.024 14.3 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 MarR family MarR PF01047.17 EFX00449.1 - 0.03 14.0 0.0 0.12 12.0 0.0 2.0 2 0 0 2 2 2 0 MarR family RE_HaeII PF09554.5 EFX00449.1 - 0.2 10.6 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 HaeII restriction endonuclease PLDc_2 PF13091.1 EFX00450.1 - 3.4e-16 59.1 0.0 4.2e-11 42.6 0.0 2.9 3 1 0 3 3 3 2 PLD-like domain PLDc PF00614.17 EFX00450.1 - 0.0018 18.0 0.0 0.024 14.4 0.0 2.4 2 0 0 2 2 2 1 Phospholipase D Active site motif G-gamma PF00631.17 EFX00451.1 - 3.2e-27 94.0 0.0 4e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 GGL domain Adeno_PIX PF03955.9 EFX00452.1 - 0.12 12.8 1.4 0.16 12.5 0.9 1.3 1 1 0 1 1 1 0 Adenovirus hexon-associated protein (IX) zf-CHCC PF10276.4 EFX00453.1 - 5.1e-15 55.0 2.6 7.7e-15 54.4 1.8 1.3 1 0 0 1 1 1 1 Zinc-finger domain PBAN PF05874.6 EFX00454.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Pheromone biosynthesis activating neuropeptide (PBAN) zf-Tim10_DDP PF02953.10 EFX00455.1 - 1e-21 75.9 5.0 1.3e-21 75.6 3.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger STE PF02200.11 EFX00456.1 - 1.8e-61 205.0 0.6 3.4e-61 204.2 0.2 1.6 2 0 0 2 2 2 1 STE like transcription factor zf-C2H2 PF00096.21 EFX00456.1 - 0.00029 20.9 3.8 0.00072 19.7 2.7 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX00456.1 - 0.00084 19.5 2.3 0.0021 18.2 1.6 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger HNH_2 PF13391.1 EFX00457.1 - 0.0023 17.6 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 HNH endonuclease Lipase_3 PF01764.20 EFX00458.1 - 4e-20 71.8 0.0 6.8e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 EFX00458.1 - 0.11 11.8 0.3 5.8 6.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) zf-C2H2_4 PF13894.1 EFX00459.1 - 0.062 13.6 0.8 0.16 12.3 0.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX00459.1 - 0.15 12.4 4.4 0.37 11.2 3.1 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type Fer2 PF00111.22 EFX00460.1 - 1.4e-12 47.1 1.0 1.4e-12 47.1 0.7 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain FAD_binding_4 PF01565.18 EFX00462.1 - 8.3e-20 70.6 1.4 2.2e-19 69.2 0.9 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 EFX00462.1 - 1.4e-05 24.8 0.3 4.1e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Berberine and berberine like Homeobox PF00046.24 EFX00463.1 - 3.7e-19 68.1 3.7 7.1e-19 67.1 2.6 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EFX00463.1 - 0.0051 16.4 0.6 0.015 14.9 0.4 1.8 1 0 0 1 1 1 1 Homeobox KN domain CorA PF01544.13 EFX00464.1 - 0.00011 21.3 3.2 0.00026 20.1 2.2 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Oxidored-like PF09791.4 EFX00465.1 - 5.7e-24 83.2 3.3 1.2e-23 82.3 2.3 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal PI-PLC-X PF00388.14 EFX00466.1 - 2.4e-59 198.9 0.0 3.9e-59 198.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EFX00466.1 - 5.7e-38 129.5 0.5 1.4e-37 128.2 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 EFX00466.1 - 0.016 15.0 0.0 0.65 9.8 0.0 2.5 2 0 0 2 2 2 0 C2 domain EF-hand_like PF09279.6 EFX00466.1 - 0.19 11.7 0.0 14 5.7 0.0 2.5 1 1 1 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like SR-25 PF10500.4 EFX00466.1 - 0.3 10.5 22.8 0.012 15.1 11.3 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.4 EFX00466.1 - 0.94 8.2 7.2 1.2 7.9 4.3 1.5 2 0 0 2 2 2 0 Golgi-body localisation protein domain TFIIF_alpha PF05793.7 EFX00466.1 - 1.1 7.5 12.8 2 6.6 8.8 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Methyltransf_23 PF13489.1 EFX00467.1 - 1.6e-08 34.4 0.0 3.2e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX00467.1 - 8.7e-08 32.4 0.0 1.6e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00467.1 - 2.8e-07 30.9 0.0 1.2e-06 28.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX00467.1 - 1.1e-06 28.6 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00467.1 - 1.7e-06 28.6 0.0 3.4e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00467.1 - 6.3e-06 25.8 0.0 0.047 13.2 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00467.1 - 0.00066 20.1 0.0 0.0027 18.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX00467.1 - 0.062 12.6 0.0 0.63 9.3 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase small domain Methyltransf_32 PF13679.1 EFX00467.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFX00467.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MFS_1 PF07690.11 EFX00468.1 - 2.6e-26 92.1 28.8 4.7e-26 91.3 19.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily FixQ PF05545.6 EFX00468.1 - 0.11 12.1 16.4 0.039 13.5 0.8 4.2 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ OPT PF03169.10 EFX00469.1 - 8.8e-79 265.5 23.7 1.3e-78 264.9 16.5 1.2 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Isochorismatase PF00857.15 EFX00469.1 - 2.8e-18 66.4 0.0 5e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family DUF4231 PF14015.1 EFX00469.1 - 5.3 7.0 12.8 0.45 10.5 1.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Cyclin PF08613.6 EFX00470.1 - 1.2e-37 129.6 0.0 1.7e-37 129.1 0.0 1.2 1 0 0 1 1 1 1 Cyclin ADH_zinc_N_2 PF13602.1 EFX00471.1 - 6.5e-18 65.8 0.0 2.3e-17 64.0 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFX00471.1 - 1.3e-15 57.1 0.1 4.5e-15 55.3 0.0 1.9 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX00471.1 - 9.6e-06 25.3 0.0 0.00039 20.1 0.0 2.7 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 EFX00471.1 - 0.00021 21.3 0.0 0.002 18.1 0.0 2.2 2 0 0 2 2 2 1 NADH(P)-binding DFP PF04127.10 EFX00471.1 - 0.0013 18.4 0.1 0.0026 17.4 0.0 1.5 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein DapB_N PF01113.15 EFX00471.1 - 0.024 14.5 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Phage_holin_6 PF10746.4 EFX00471.1 - 0.063 13.0 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Phage holin family 6 Eno-Rase_NADH_b PF12242.3 EFX00471.1 - 0.1 12.4 1.0 0.21 11.3 0.4 1.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CorA PF01544.13 EFX00473.1 - 4.8e-42 143.9 0.2 7.6e-42 143.3 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein UQ_con PF00179.21 EFX00474.1 - 5.9e-27 93.8 0.1 7.8e-27 93.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Lectin_leg-like PF03388.8 EFX00475.1 - 1.9e-66 223.4 0.0 2.6e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family ATG27 PF09451.5 EFX00475.1 - 0.0027 16.9 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 Lectin_legB PF00139.14 EFX00475.1 - 0.0099 15.2 0.0 0.78 9.0 0.0 2.3 2 0 0 2 2 2 2 Legume lectin domain FAA_hydrolase PF01557.13 EFX00476.1 - 3.6e-64 216.2 0.0 6.2e-64 215.4 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_6 PF12697.2 EFX00476.1 - 2.3e-36 125.7 6.7 3.8e-36 125.1 4.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX00476.1 - 6e-19 68.5 0.1 1.6e-16 60.6 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX00476.1 - 5.4e-15 55.4 0.7 4.4e-14 52.4 0.5 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 EFX00476.1 - 5.5e-12 45.6 3.0 3.9e-06 26.5 0.1 2.3 1 1 1 2 2 2 2 Serine hydrolase Abhydrolase_4 PF08386.5 EFX00476.1 - 7.6e-07 28.9 0.1 1.7e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 TAP-like protein PGAP1 PF07819.8 EFX00476.1 - 0.038 13.5 0.0 0.08 12.5 0.0 1.5 1 1 0 1 1 1 0 PGAP1-like protein Abhydrolase_2 PF02230.11 EFX00476.1 - 0.041 13.3 0.1 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FSH1 PF03959.8 EFX00476.1 - 0.071 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PhoPQ_related PF10142.4 EFX00476.1 - 0.087 11.2 0.0 0.12 10.8 0.0 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Peptidase_S9 PF00326.16 EFX00476.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family TPR_11 PF13414.1 EFX00477.1 - 2.6e-41 139.0 26.9 1.8e-18 65.9 1.3 5.8 4 2 1 5 5 5 4 TPR repeat TPR_1 PF00515.23 EFX00477.1 - 1.4e-32 109.9 17.8 4.8e-07 29.1 0.1 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00477.1 - 5.6e-30 100.8 23.7 1.1e-05 24.9 0.0 8.5 8 1 0 8 8 8 7 Tetratricopeptide repeat DnaJ PF00226.26 EFX00477.1 - 1.1e-28 98.6 6.4 6.6e-28 96.2 2.7 2.6 2 0 0 2 2 2 1 DnaJ domain TPR_16 PF13432.1 EFX00477.1 - 7.1e-20 71.1 38.9 4.4e-07 30.3 0.7 6.8 6 2 1 7 7 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFX00477.1 - 8.4e-17 60.8 20.6 8.7e-07 28.7 0.6 6.3 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00477.1 - 9.4e-17 61.1 25.0 3.5e-07 30.4 0.2 6.2 5 2 2 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 EFX00477.1 - 3.8e-16 57.8 14.5 0.00017 21.5 0.0 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFX00477.1 - 6.3e-15 54.3 28.7 0.00036 20.8 0.2 8.7 4 3 5 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 EFX00477.1 - 1.6e-12 46.2 5.5 0.29 11.0 0.0 7.0 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 EFX00477.1 - 7.5e-12 44.9 14.8 0.012 15.4 0.1 5.2 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 EFX00477.1 - 1.4e-10 40.1 12.5 0.12 12.2 0.0 7.2 8 0 0 8 8 6 4 Tetratricopeptide repeat Apc3 PF12895.2 EFX00477.1 - 5.1e-10 39.3 6.6 0.00028 20.9 0.1 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EFX00477.1 - 5.5e-05 23.3 22.5 0.18 12.3 0.0 9.0 10 1 1 11 11 9 2 Tetratricopeptide repeat SHNi-TPR PF10516.4 EFX00477.1 - 0.00062 18.9 2.9 0.68 9.2 0.0 3.4 3 0 0 3 3 3 2 SHNi-TPR TPR_4 PF07721.9 EFX00477.1 - 0.0012 19.0 7.2 0.015 15.6 0.2 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat DUF928 PF06051.7 EFX00477.1 - 0.0088 15.6 0.4 0.019 14.5 0.3 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF928) BTAD PF03704.12 EFX00477.1 - 0.026 14.8 12.6 7.5 6.8 0.1 4.3 3 1 0 3 3 3 0 Bacterial transcriptional activator domain RRM_3 PF08777.6 EFX00477.1 - 0.073 12.9 0.1 0.073 12.9 0.1 2.3 3 0 0 3 3 1 0 RNA binding motif ChAPs PF09295.5 EFX00477.1 - 0.31 9.7 1.2 0.43 9.2 0.0 1.8 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Fis1_TPR_C PF14853.1 EFX00477.1 - 0.55 10.1 7.3 27 4.7 0.0 4.5 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat DUF89 PF01937.14 EFX00478.1 - 6.8e-131 436.2 0.0 7.7e-131 436.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF4363 PF14276.1 EFX00478.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) p450 PF00067.17 EFX00479.1 - 8.9e-39 133.2 0.0 2.2e-38 131.9 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Ku PF02735.11 EFX00480.1 - 8.6e-28 97.1 0.0 1.4e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 EFX00480.1 - 3.3e-22 79.0 0.0 6.7e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind PF08785.6 EFX00480.1 - 4.2e-13 49.2 0.0 1.2e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Ku C terminal domain like VWA_2 PF13519.1 EFX00480.1 - 5.3e-05 23.3 0.0 0.00012 22.1 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EFX00480.1 - 0.043 13.5 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Prp19_bind PF06991.6 EFX00481.1 - 5.8e-36 124.1 46.5 5.8e-36 124.1 32.2 2.7 1 1 1 2 2 2 1 Splicing factor, Prp19-binding domain Na_H_Exchanger PF00999.16 EFX00483.1 - 7.5e-69 232.0 33.6 9.2e-69 231.7 23.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DnaJ PF00226.26 EFX00484.1 - 3e-07 30.0 0.0 4.1e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 EFX00484.1 - 3.1e-06 27.0 0.1 3.5e-06 26.8 0.0 1.3 1 1 0 1 1 1 1 Pam16 DUF676 PF05057.9 EFX00485.1 - 0.043 13.0 0.0 0.082 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) ssDNA-exonuc_C PF10141.4 EFX00485.1 - 4.5 6.7 6.3 13 5.1 0.6 2.3 2 0 0 2 2 2 0 Single-strand DNA-specific exonuclease, C terminal domain GSH_synth_ATP PF03917.12 EFX00487.1 - 2.7e-103 345.3 0.0 1.2e-102 343.2 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 EFX00487.1 - 3.1e-29 101.1 0.0 6.8e-29 100.0 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic glutathione synthase UCH PF00443.24 EFX00488.1 - 6.7e-74 248.3 0.0 5.4e-73 245.4 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX00488.1 - 8.6e-18 64.7 0.0 1.5e-09 37.7 0.0 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 EFX00488.1 - 4.3e-09 36.6 0.0 1.2e-08 35.2 0.0 1.8 1 0 0 1 1 1 1 DUSP domain zf-FPG_IleRS PF06827.9 EFX00488.1 - 0.022 14.4 1.4 1.9 8.2 0.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Methyltransf_23 PF13489.1 EFX00489.1 - 1.6e-18 66.9 0.0 2.1e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00489.1 - 1.7e-09 37.4 0.0 2.8e-08 33.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00489.1 - 8.6e-08 32.7 0.0 1.6e-06 28.6 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00489.1 - 1.4e-06 28.6 0.0 1.1e-05 25.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00489.1 - 1.1e-05 25.8 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX00489.1 - 0.0023 17.3 0.0 0.042 13.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_16 PF10294.4 EFX00489.1 - 0.0028 17.1 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 EFX00489.1 - 0.0038 17.2 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.1 EFX00489.1 - 0.005 17.1 0.0 0.014 15.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFX00489.1 - 0.029 13.5 0.0 0.13 11.3 0.0 2.0 3 0 0 3 3 3 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EFX00489.1 - 0.032 14.2 0.0 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EFX00489.1 - 0.087 11.8 0.0 0.26 10.3 0.0 1.8 1 0 0 1 1 1 0 Putative methyltransferase F-box-like PF12937.2 EFX00490.1 - 0.46 10.2 0.0 0.46 10.2 0.0 3.6 4 0 0 4 4 4 0 F-box-like Pyr_redox_3 PF13738.1 EFX00491.1 - 1e-19 71.4 0.0 1.9e-18 67.2 0.0 2.6 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX00491.1 - 2e-13 49.3 0.0 1.3e-09 36.8 0.0 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX00491.1 - 1.3e-11 44.3 0.0 4.1e-11 42.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX00491.1 - 3.3e-06 26.9 0.0 3e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 EFX00491.1 - 4.7e-06 25.7 0.0 0.006 15.5 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 EFX00491.1 - 0.00013 20.9 0.0 0.0027 16.6 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFX00491.1 - 0.014 14.3 0.1 0.029 13.2 0.0 1.6 1 1 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.9 EFX00491.1 - 0.018 13.5 0.0 0.031 12.7 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.12 EFX00491.1 - 0.026 13.6 0.0 0.055 12.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 EFX00491.1 - 0.042 13.7 0.0 0.63 9.8 0.0 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX00491.1 - 0.15 10.8 0.0 0.29 9.9 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain DUF356 PF04009.7 EFX00492.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF356) Baculo_PEP_C PF04513.7 EFX00492.1 - 0.23 11.2 16.6 1 9.1 7.0 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3235 PF11574.3 EFX00492.1 - 0.33 11.2 2.3 6.3 7.1 1.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3235) Ornatin PF02088.10 EFX00493.1 - 0.011 15.2 2.5 0.031 13.8 1.8 1.8 1 0 0 1 1 1 0 Ornatin FUN14 PF04930.10 EFX00494.1 - 0.0004 20.6 3.2 0.0046 17.2 2.2 2.1 1 1 0 1 1 1 1 FUN14 family Pyr_redox_3 PF13738.1 EFX00495.1 - 4.7e-20 72.5 0.1 3.2e-19 69.7 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX00495.1 - 1.1e-14 53.5 0.4 4.6e-14 51.5 0.2 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFX00495.1 - 5.5e-09 36.2 0.1 5.1e-07 29.7 0.1 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX00495.1 - 1.6e-07 30.5 0.0 3.3e-05 22.9 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFX00495.1 - 1.9e-06 27.7 0.2 1.9e-06 27.7 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX00495.1 - 9.2e-06 24.7 0.7 2.6e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFX00495.1 - 0.00013 22.3 3.8 0.021 15.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 EFX00495.1 - 0.0012 18.9 0.1 0.089 12.9 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.16 EFX00495.1 - 0.0076 15.8 0.4 0.49 9.9 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 EFX00495.1 - 0.017 14.7 1.0 0.034 13.8 0.7 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 EFX00495.1 - 0.032 14.4 0.0 0.57 10.4 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.1 EFX00495.1 - 0.067 12.9 4.6 0.27 11.0 0.2 3.3 3 1 1 4 4 4 0 FAD-NAD(P)-binding HI0933_like PF03486.9 EFX00495.1 - 0.26 9.6 3.3 0.38 9.1 0.4 2.1 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.19 EFX00495.1 - 0.44 9.3 7.5 0.036 12.9 1.4 1.9 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.12 EFX00495.1 - 0.48 9.4 1.8 1.2 8.1 0.2 2.0 2 0 0 2 2 2 0 Thi4 family Adap_comp_sub PF00928.16 EFX00496.1 - 1.1e-90 303.3 0.0 1.4e-90 302.9 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EFX00496.1 - 1.3e-08 34.6 0.2 2.1e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.4 EFX00496.1 - 0.064 12.4 0.0 0.27 10.3 0.0 1.8 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain BMF PF15185.1 EFX00497.1 - 5.4 6.2 6.5 6.2 6.0 4.5 1.1 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis Voltage_CLC PF00654.15 EFX00498.1 - 1.5e-90 303.7 21.8 2.9e-90 302.8 15.1 1.4 1 0 0 1 1 1 1 Voltage gated chloride channel FUSC PF04632.7 EFX00498.1 - 0.14 10.5 6.8 0.28 9.5 4.7 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF221 PF02714.10 EFX00499.1 - 1.9e-91 306.3 18.4 2.8e-91 305.7 12.8 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFX00499.1 - 2.8e-26 91.9 1.5 2.8e-26 91.9 1.1 2.0 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 EFX00499.1 - 5.5e-17 62.0 0.8 1.1e-16 61.1 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) PseudoU_synth_1 PF01416.15 EFX00500.1 - 3.8e-21 75.4 0.0 1.1e-09 38.5 0.0 2.7 2 0 0 2 2 2 2 tRNA pseudouridine synthase Ribosomal_S8e PF01201.17 EFX00501.1 - 0.65 10.1 6.0 2.4 8.2 0.3 2.5 2 1 0 2 2 2 0 Ribosomal protein S8e DUF2347 PF09804.4 EFX00502.1 - 5.4e-94 314.6 0.0 8.2e-94 314.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 EFX00502.1 - 8.1e-44 149.8 0.9 1.4e-27 96.9 0.8 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4484) SPA PF08616.5 EFX00502.1 - 7.7e-06 25.5 0.0 2.3e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 EFX00502.1 - 0.28 9.6 0.0 4.9 5.5 0.0 2.1 2 0 0 2 2 2 0 Transport protein Avl9 Daxx PF03344.10 EFX00502.1 - 2.9 6.2 5.3 4.8 5.5 3.7 1.2 1 0 0 1 1 1 0 Daxx Family DUF1295 PF06966.7 EFX00503.1 - 1.6e-38 132.3 8.9 2.1e-38 131.9 6.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 EFX00503.1 - 0.042 14.0 0.1 3.7 7.8 0.0 2.5 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family TRI12 PF06609.8 EFX00504.1 - 5e-55 186.8 27.3 5.9e-55 186.5 18.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.11 EFX00504.1 - 4.8e-29 101.1 51.6 4.8e-29 101.1 35.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX00504.1 - 4.5e-09 35.3 8.2 4.5e-09 35.3 5.7 3.6 3 1 0 4 4 4 1 Sugar (and other) transporter MFS_2 PF13347.1 EFX00504.1 - 1.7e-05 23.3 2.2 1.7e-05 23.3 1.6 3.0 1 1 1 3 3 3 1 MFS/sugar transport protein SH3_1 PF00018.23 EFX00505.1 - 2e-05 23.8 0.0 4.5e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFX00505.1 - 0.0091 15.5 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SoxE PF06525.6 EFX00505.1 - 0.032 13.4 0.1 0.095 11.9 0.1 1.7 1 0 0 1 1 1 0 Sulfocyanin (SoxE) Fungal_trans PF04082.13 EFX00506.1 - 3.9e-21 75.1 0.6 5.6e-21 74.5 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX00506.1 - 7.7e-08 32.1 8.9 1.3e-07 31.4 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 EFX00507.1 - 9.8e-95 317.7 24.2 1.2e-94 317.4 16.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX00507.1 - 1.5e-31 109.4 34.3 7.8e-24 84.0 7.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX00507.1 - 0.011 14.1 33.1 0.0067 14.8 3.7 3.4 2 2 1 3 3 3 0 MFS/sugar transport protein Opi1 PF08618.5 EFX00510.1 - 3.6e-83 279.8 2.0 1e-54 186.1 0.1 3.3 2 1 1 3 3 3 3 Transcription factor Opi1 SAC3_GANP PF03399.11 EFX00511.1 - 0.013 15.1 0.4 0.019 14.5 0.3 1.2 1 0 0 1 1 1 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family TIP120 PF08623.5 EFX00512.1 - 8.4e-59 197.9 0.0 5.3e-56 188.8 0.0 4.0 2 1 2 4 4 4 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.1 EFX00512.1 - 1.1e-12 48.1 49.1 0.0036 17.5 0.4 9.3 8 2 3 11 11 11 7 HEAT repeats DUF2435 PF10363.4 EFX00512.1 - 2.9e-07 30.2 7.9 0.0022 17.8 0.2 5.1 6 0 0 6 6 6 3 Protein of unknown function (DUF2435) HEAT PF02985.17 EFX00512.1 - 7.3e-06 25.6 31.9 0.56 10.4 0.0 11.6 14 0 0 14 14 11 3 HEAT repeat Cnd1 PF12717.2 EFX00512.1 - 7.6e-06 25.8 5.8 3.8 7.3 0.0 6.7 7 2 0 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 EFX00512.1 - 0.00018 19.9 12.9 0.022 13.0 0.3 6.1 3 3 2 5 5 5 2 Adaptin N terminal region Ipi1_N PF12333.3 EFX00512.1 - 0.00026 20.9 1.7 0.87 9.5 0.0 4.9 5 0 0 5 5 5 1 Rix1 complex component involved in 60S ribosome maturation UME PF08064.8 EFX00512.1 - 0.043 13.7 5.3 7.9 6.4 0.0 5.8 6 2 1 7 7 7 0 UME (NUC010) domain VHS PF00790.14 EFX00512.1 - 0.063 12.9 0.0 1.6 8.3 0.0 2.9 2 0 0 2 2 2 0 VHS domain DUF3437 PF11919.3 EFX00512.1 - 0.2 11.3 1.3 2.8 7.7 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3437) HEAT_EZ PF13513.1 EFX00512.1 - 0.39 11.2 49.8 1.7 9.2 1.6 12.0 11 3 3 14 14 13 0 HEAT-like repeat Peptidase_S10 PF00450.17 EFX00513.1 - 3.7e-130 434.8 0.7 4.6e-130 434.5 0.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.6 EFX00513.1 - 5.1e-07 29.8 0.0 1.1e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Abhydrolase_6 PF12697.2 EFX00513.1 - 0.00019 21.4 0.1 0.0061 16.4 0.0 2.8 3 1 0 3 3 3 1 Alpha/beta hydrolase family adh_short PF00106.20 EFX00515.1 - 8.7e-07 28.9 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX00515.1 - 6.1e-06 26.0 0.0 1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Hpr_kinase_C PF07475.7 EFX00515.1 - 0.041 13.2 0.0 6.3 6.0 0.1 2.2 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain DUF258 PF03193.11 EFX00515.1 - 0.17 11.0 0.1 0.29 10.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 EFX00515.1 - 0.29 10.2 1.7 1.9 7.5 0.1 2.3 2 1 0 2 2 2 0 Zeta toxin TIM PF00121.13 EFX00516.1 - 2.4e-50 170.8 0.0 2.9e-50 170.6 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase Aminotran_1_2 PF00155.16 EFX00517.1 - 6.7e-62 209.5 0.0 8.7e-62 209.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFX00517.1 - 0.01 15.0 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.14 EFX00517.1 - 0.18 10.5 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFX00517.1 - 0.2 10.6 0.0 0.33 9.9 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family HTH_31 PF13560.1 EFX00518.1 - 0.024 14.8 0.1 0.085 13.0 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain Kinesin PF00225.18 EFX00519.1 - 1.4e-104 349.4 0.3 1.4e-104 349.4 0.2 2.2 2 0 0 2 2 2 1 Kinesin motor domain WEMBL PF05701.6 EFX00519.1 - 0.18 10.2 53.2 0.0065 14.9 32.5 1.7 2 0 0 2 2 2 0 Weak chloroplast movement under blue light AAA_22 PF13401.1 EFX00519.1 - 0.34 11.0 9.2 1.2 9.2 0.3 2.9 2 1 0 2 2 2 0 AAA domain FSH1 PF03959.8 EFX00520.1 - 5.5e-22 78.2 0.0 7.7e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) 2OG-FeII_Oxy PF03171.15 EFX00521.1 - 1.5e-21 76.5 0.0 2.8e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EFX00521.1 - 3.5e-20 72.6 0.0 5.1e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal SET PF00856.23 EFX00522.1 - 4.9e-10 39.9 0.0 1.7e-09 38.1 0.0 1.9 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.6 EFX00522.1 - 4.4e-09 36.3 0.7 8.7e-09 35.3 0.5 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding HTH_Tnp_Tc5 PF03221.11 EFX00523.1 - 9.6e-13 47.7 0.0 4.7e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 EFX00523.1 - 1.8e-05 24.0 0.0 3.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_4 PF13613.1 EFX00523.1 - 0.0083 15.6 0.0 0.026 14.0 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix of DDE superfamily endonuclease MarR PF01047.17 EFX00523.1 - 0.051 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.1 EFX00523.1 - 0.054 13.3 0.0 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_23 PF13384.1 EFX00523.1 - 0.12 12.0 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain DUF3580 PF12117.3 EFX00526.1 - 0.15 12.0 2.2 0.49 10.3 1.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) HlyIII PF03006.15 EFX00527.1 - 3.3e-58 196.7 13.7 3e-56 190.2 9.5 2.5 1 1 0 1 1 1 1 Haemolysin-III related DHFR_1 PF00186.14 EFX00528.1 - 5.8e-31 107.2 0.0 7.8e-31 106.8 0.0 1.3 1 1 0 1 1 1 1 Dihydrofolate reductase zf-C2H2_4 PF13894.1 EFX00529.1 - 1.3e-05 25.1 13.1 0.00059 19.9 1.8 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX00529.1 - 0.0041 17.3 14.5 0.027 14.8 1.0 4.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFX00529.1 - 0.0074 16.5 10.4 0.6 10.5 0.6 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-Di19 PF05605.7 EFX00529.1 - 1 9.5 4.8 0.46 10.6 0.7 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Nop14 PF04147.7 EFX00529.1 - 3.4 5.4 11.4 4.7 5.0 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family PUA PF01472.15 EFX00530.1 - 6e-11 41.9 0.1 5.4e-10 38.8 0.1 2.0 1 1 0 1 1 1 1 PUA domain DER1 PF04511.10 EFX00531.1 - 3.6e-50 170.2 8.9 4.1e-50 170.0 6.2 1.0 1 0 0 1 1 1 1 Der1-like family His_Phos_2 PF00328.17 EFX00532.1 - 2.9e-08 33.4 0.3 8e-07 28.7 0.2 2.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) UFD1 PF03152.9 EFX00533.1 - 1.3e-26 92.7 0.0 2.6e-26 91.8 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Man-6-P_recep PF02157.10 EFX00534.1 - 3.6e-11 42.6 0.0 4.9e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.13 EFX00534.1 - 1.8e-06 27.7 0.1 0.029 14.1 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.5 EFX00534.1 - 0.013 14.7 0.3 0.083 12.1 0.1 2.1 1 1 0 1 1 1 0 Autophagy-related protein 27 Methyltransf_11 PF08241.7 EFX00536.1 - 2.3e-09 37.6 0.0 5.8e-09 36.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX00536.1 - 4.6e-08 32.9 0.0 1.8e-07 30.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX00536.1 - 0.00026 20.1 0.0 0.00042 19.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFX00536.1 - 0.00052 20.4 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFX00536.1 - 0.0026 17.4 0.0 0.0084 15.7 0.0 1.8 2 1 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_31 PF13847.1 EFX00536.1 - 0.01 15.4 0.0 0.11 12.0 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain eIF3_subunit PF08597.5 EFX00538.1 - 9.1e-62 208.8 12.9 1e-61 208.6 9.0 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Daxx PF03344.10 EFX00538.1 - 5.8 5.2 14.1 1.6 7.0 7.3 1.8 2 0 0 2 2 2 0 Daxx Family Nop53 PF07767.6 EFX00538.1 - 8.7 5.2 22.2 0.65 8.9 10.9 1.9 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Cytochrom_B561 PF03188.11 EFX00539.1 - 0.00012 21.8 12.2 0.0003 20.6 8.4 1.7 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 TMEM192 PF14802.1 EFX00539.1 - 0.018 13.9 0.0 0.035 12.9 0.0 1.4 1 0 0 1 1 1 0 TMEM192 family DUF3382 PF11862.3 EFX00539.1 - 0.12 12.2 0.1 0.12 12.2 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) DUF2427 PF10348.4 EFX00539.1 - 0.47 10.0 16.0 17 5.0 0.0 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2427) MARVEL PF01284.18 EFX00539.1 - 2.6 7.8 11.7 4.4 7.1 0.1 2.6 3 1 0 3 3 3 0 Membrane-associating domain Myb_DNA-binding PF00249.26 EFX00540.1 - 0.0013 18.7 0.0 0.0032 17.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_L27 PF01016.14 EFX00541.1 - 3.5e-21 74.7 0.1 8e-21 73.6 0.0 1.7 1 0 0 1 1 1 1 Ribosomal L27 protein ABC_tran PF00005.22 EFX00542.1 - 9.9e-32 110.0 0.0 2.2e-31 108.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EFX00542.1 - 1.5e-21 77.0 8.1 2.2e-21 76.5 5.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 EFX00542.1 - 1.5e-05 24.3 0.0 3.2e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX00542.1 - 0.00055 20.0 0.0 0.043 13.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 EFX00542.1 - 0.0029 17.4 0.3 0.045 13.6 0.2 2.7 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 EFX00542.1 - 0.026 14.0 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 EFX00542.1 - 0.027 13.6 0.0 0.084 12.0 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFX00542.1 - 0.038 13.4 0.0 0.22 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain KH_1 PF00013.24 EFX00543.1 - 5e-39 131.7 12.8 1.5e-14 53.3 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EFX00543.1 - 2.1e-29 100.6 14.4 6e-11 41.7 0.6 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EFX00543.1 - 7.8e-10 38.1 10.4 0.004 16.6 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EFX00543.1 - 6.9e-07 28.8 6.4 0.085 12.5 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 EFX00543.1 - 0.00044 19.9 4.4 0.64 9.8 0.0 3.3 3 0 0 3 3 3 2 NusA-like KH domain dUTPase PF00692.14 EFX00543.1 - 0.004 16.6 0.7 0.71 9.3 0.1 3.1 3 0 0 3 3 3 1 dUTPase Cyto_heme_lyase PF01265.12 EFX00544.1 - 1.1e-74 251.3 0.0 1.3e-74 251.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase CENP-B_dimeris PF09026.5 EFX00545.1 - 6.4 7.0 10.1 12 6.1 7.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF1446 PF07287.6 EFX00546.1 - 6.1e-121 403.2 0.0 7.3e-121 403.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) RAI16-like PF10257.4 EFX00547.1 - 9.9e-81 271.3 0.4 1.4e-80 270.8 0.3 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Rdx PF10262.4 EFX00548.1 - 3.9e-29 100.4 0.0 5.3e-29 100.0 0.0 1.2 1 0 0 1 1 1 1 Rdx family zf-TFIIB PF13453.1 EFX00548.1 - 0.065 12.4 0.1 4.8 6.4 0.1 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger ICMT PF04140.9 EFX00549.1 - 1.6e-12 47.4 0.6 8.1e-10 38.7 0.0 2.5 1 1 1 2 2 2 2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 EFX00549.1 - 2.5e-09 37.1 0.7 2.6e-08 33.9 0.2 2.4 1 1 1 2 2 2 1 Phospholipid methyltransferase Menin PF05053.8 EFX00550.1 - 8.2 4.4 7.2 1.6 6.8 2.5 1.5 2 0 0 2 2 2 0 Menin DUF1762 PF08574.5 EFX00551.1 - 1.3e-07 31.9 13.4 1.3e-07 31.9 9.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1762) STE3 PF02076.10 EFX00552.1 - 2.6e-36 125.1 17.6 3.2e-36 124.8 12.2 1.1 1 0 0 1 1 1 1 Pheromone A receptor 2OG-FeII_Oxy PF03171.15 EFX00553.1 - 0.00032 20.9 0.0 0.00075 19.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.2 EFX00553.1 - 0.017 14.8 0.6 0.093 12.4 0.0 2.7 3 0 0 3 3 3 0 F-box-like DIOX_N PF14226.1 EFX00553.1 - 0.024 15.1 0.0 0.075 13.5 0.0 1.8 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal Pectate_lyase_3 PF12708.2 EFX00554.1 - 3.1e-86 289.1 23.0 1.1e-70 238.2 6.3 3.1 3 1 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 EFX00554.1 - 1.1e-07 31.1 2.4 0.0022 17.4 0.1 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.1 EFX00554.1 - 0.0006 19.6 8.6 0.0006 19.6 6.0 3.9 3 2 2 5 5 5 1 Right handed beta helix region NosD PF05048.8 EFX00554.1 - 0.0014 17.8 5.1 0.0014 17.8 3.5 2.3 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Period_C PF12114.3 EFX00554.1 - 0.16 11.5 0.1 0.58 9.7 0.0 2.0 2 0 0 2 2 2 0 Period protein 2/3C-terminal region COesterase PF00135.23 EFX00556.1 - 2.2e-71 241.2 0.0 2.3e-43 148.7 0.0 2.0 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX00556.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ribosomal_L18e PF00828.14 EFX00557.1 - 9.5e-33 113.3 0.0 1.3e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 DUF3194 PF11419.3 EFX00558.1 - 0.37 11.0 3.8 0.54 10.4 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) SMC_N PF02463.14 EFX00559.1 - 2.7e-62 209.8 16.3 7.3e-62 208.4 11.3 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EFX00559.1 - 3.7e-26 91.4 0.0 1.3e-25 89.6 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EFX00559.1 - 4.4e-21 76.1 0.3 4.4e-21 76.1 0.2 6.5 2 2 4 6 6 6 1 AAA domain AAA_21 PF13304.1 EFX00559.1 - 3.7e-16 59.9 0.0 1.1e-06 28.8 0.0 3.0 3 1 0 3 3 3 2 AAA domain AAA_15 PF13175.1 EFX00559.1 - 4.2e-07 29.3 1.2 0.00026 20.1 0.3 3.6 2 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.1 EFX00559.1 - 0.0005 19.5 0.0 0.0013 18.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Mod_r PF07200.8 EFX00559.1 - 0.0014 18.5 5.8 0.0014 18.5 4.0 7.1 4 2 2 7 7 7 1 Modifier of rudimentary (Mod(r)) protein Reo_sigmaC PF04582.7 EFX00559.1 - 0.0044 16.2 15.2 0.12 11.5 0.1 4.3 3 1 1 4 4 4 3 Reovirus sigma C capsid protein Mito_carr PF00153.22 EFX00560.1 - 8.5e-69 227.3 1.0 2e-22 78.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein BUD22 PF09073.5 EFX00561.1 - 3.8e-59 200.8 62.0 2.3e-46 158.7 19.5 2.4 2 1 1 3 3 3 2 BUD22 ATP-synt_DE_N PF02823.11 EFX00562.1 - 1.6e-19 69.4 0.0 2.4e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain adh_short PF00106.20 EFX00564.1 - 6.6e-13 48.9 0.1 1.3e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX00564.1 - 0.0019 17.9 0.0 0.0041 16.7 0.0 1.6 1 0 0 1 1 1 1 KR domain CAF1A PF12253.3 EFX00565.1 - 8.9e-08 32.1 15.9 1.5e-07 31.4 11.0 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A PPV_E1_N PF00524.13 EFX00565.1 - 0.87 9.8 6.6 1.6 8.9 4.6 1.3 1 0 0 1 1 1 0 E1 Protein, N terminal domain SDA1 PF05285.7 EFX00565.1 - 6.3 5.9 11.5 2.1 7.5 5.8 1.6 2 0 0 2 2 2 0 SDA1 Glyco_hydro_30 PF02055.11 EFX00566.1 - 5.5e-46 156.8 0.2 8.3e-46 156.2 0.1 1.2 1 0 0 1 1 1 1 O-Glycosyl hydrolase family 30 DUF2015 PF09435.5 EFX00567.1 - 1.6e-40 137.8 0.0 1.8e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) EcKinase PF02958.15 EFX00569.1 - 4.2e-23 81.9 0.0 1.1e-12 47.7 0.0 2.2 2 0 0 2 2 2 2 Ecdysteroid kinase DUF1679 PF07914.6 EFX00569.1 - 1.3e-09 37.2 0.0 1.9e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.18 EFX00569.1 - 1.4e-08 34.7 4.0 2.5e-08 33.9 2.7 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family TPR_11 PF13414.1 EFX00570.1 - 1.5e-12 46.9 0.1 5.5e-08 32.3 0.0 2.5 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.12 EFX00570.1 - 2.8e-07 29.9 5.8 0.00076 19.2 0.1 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFX00570.1 - 7.7e-06 25.7 0.4 0.012 15.5 0.1 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX00570.1 - 7e-05 22.2 2.8 0.13 11.9 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX00570.1 - 0.00025 21.6 1.2 0.0092 16.6 0.2 3.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX00570.1 - 0.01 15.5 1.1 1.4 8.8 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00570.1 - 0.015 15.6 1.3 0.074 13.4 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFX00570.1 - 0.13 12.9 6.1 0.12 13.0 0.5 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 EFX00570.1 - 0.13 12.3 0.0 1.9 8.7 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Zn_clus PF00172.13 EFX00570.1 - 0.6 10.0 4.9 1.2 9.0 3.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_2 PF04059.7 EFX00571.1 - 2.8e-27 94.5 0.2 7.5e-27 93.1 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif 2 RRM_1 PF00076.17 EFX00571.1 - 0.0066 16.0 0.0 0.15 11.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX00571.1 - 0.015 15.0 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX00571.1 - 0.038 13.9 0.1 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Fn3_assoc PF13287.1 EFX00571.1 - 0.1 12.6 0.8 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 Fn3 associated MFS_1 PF07690.11 EFX00572.1 - 1.3e-11 43.8 24.7 2.7e-11 42.7 17.0 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX00572.1 - 5.7e-09 35.0 14.1 2.2e-08 33.1 1.7 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter SPACA7 PF15307.1 EFX00572.1 - 0.17 12.0 0.2 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Sperm acrosome-associated protein 7 GFO_IDH_MocA PF01408.17 EFX00573.1 - 5.1e-23 81.8 0.0 9e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EFX00573.1 - 2.7e-05 23.9 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_7 PF13241.1 EFX00573.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Aldolase_II PF00596.16 EFX00574.1 - 7.4e-49 165.8 0.1 9.3e-49 165.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain BTB PF00651.26 EFX00575.1 - 3.6e-06 26.9 0.0 1.4e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain DUF3515 PF12028.3 EFX00575.1 - 0.038 13.2 0.1 0.069 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3515) Aa_trans PF01490.13 EFX00577.1 - 1.5e-27 96.1 34.2 2.4e-27 95.4 23.7 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein S1FA PF04689.8 EFX00577.1 - 1.9 8.3 4.9 3.1 7.7 0.5 2.9 3 0 0 3 3 3 0 DNA binding protein S1FA F_bP_aldolase PF01116.15 EFX00579.1 - 4.3e-79 265.6 0.1 4.8e-79 265.4 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II UAA PF08449.6 EFX00580.1 - 9.6e-14 50.9 16.0 1.2e-13 50.6 11.1 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 EFX00580.1 - 1.8e-10 40.6 5.1 1.8e-10 40.6 3.5 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 EFX00580.1 - 0.00039 20.4 24.4 0.0013 18.8 2.9 2.3 2 0 0 2 2 2 2 EamA-like transporter family UPF0370 PF13980.1 EFX00580.1 - 0.15 11.9 0.1 1.5 8.6 0.0 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0370) AAA PF00004.24 EFX00581.1 - 2.9e-41 140.7 0.0 5e-41 139.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX00581.1 - 5.8e-07 29.7 0.1 0.00019 21.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EFX00581.1 - 1.6e-06 28.1 0.0 3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EFX00581.1 - 1.2e-05 24.3 0.0 2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 EFX00581.1 - 2.6e-05 23.9 0.1 9.3e-05 22.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EFX00581.1 - 0.00029 19.9 0.0 0.00052 19.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFX00581.1 - 0.00038 20.5 1.0 0.00097 19.1 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 EFX00581.1 - 0.0012 18.8 0.8 0.004 17.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFX00581.1 - 0.002 18.0 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 EFX00581.1 - 0.0036 16.9 0.2 0.35 10.5 0.1 2.6 2 1 1 3 3 3 1 NACHT domain AAA_33 PF13671.1 EFX00581.1 - 0.0038 17.1 0.1 0.022 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX00581.1 - 0.0046 17.7 0.7 0.012 16.4 0.1 2.1 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.1 EFX00581.1 - 0.0055 16.4 0.3 0.015 15.0 0.2 1.7 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EFX00581.1 - 0.0068 15.8 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFX00581.1 - 0.0086 15.1 0.0 0.017 14.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 EFX00581.1 - 0.0088 16.3 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 EFX00581.1 - 0.0093 15.5 0.0 0.029 13.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 EFX00581.1 - 0.019 13.7 0.1 0.046 12.4 0.1 1.6 1 1 0 1 1 1 0 TIP49 C-terminus PhoH PF02562.11 EFX00581.1 - 0.026 13.7 1.0 0.21 10.8 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein KaiC PF06745.8 EFX00581.1 - 0.028 13.5 0.2 0.47 9.5 0.1 2.4 1 1 1 2 2 2 0 KaiC NB-ARC PF00931.17 EFX00581.1 - 0.038 12.8 0.0 0.065 12.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.17 EFX00581.1 - 0.044 13.9 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.16 EFX00581.1 - 0.051 12.7 0.1 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.4 EFX00581.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.1 EFX00581.1 - 0.13 11.8 2.8 0.14 11.7 0.2 2.3 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.1 EFX00581.1 - 0.21 10.9 5.3 0.27 10.6 0.3 2.7 2 1 1 3 3 3 0 AAA domain Spore_coat_CotO PF14153.1 EFX00582.1 - 0.00015 21.3 2.2 0.00015 21.3 1.5 1.7 2 0 0 2 2 2 1 Spore coat protein CotO PAT1 PF09770.4 EFX00582.1 - 0.0018 16.6 18.6 0.0026 16.1 12.9 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.8 EFX00582.1 - 0.012 15.6 26.0 0.016 15.2 10.4 3.1 3 0 0 3 3 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4366 PF14283.1 EFX00582.1 - 0.014 14.8 1.5 3 7.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Rifin_STEVOR PF02009.11 EFX00582.1 - 0.038 13.6 0.1 0.038 13.6 0.1 2.0 2 0 0 2 2 1 0 Rifin/stevor family TMEM154 PF15102.1 EFX00582.1 - 0.052 13.2 0.1 0.052 13.2 0.1 3.3 3 0 0 3 3 2 0 TMEM154 protein family DUF4011 PF13195.1 EFX00582.1 - 0.057 13.4 3.5 0.13 12.2 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) eIF-3_zeta PF05091.7 EFX00582.1 - 0.069 11.7 15.2 0.1 11.1 10.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.8 EFX00582.1 - 0.15 11.9 25.9 0.071 13.0 12.9 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pox_G7 PF05503.7 EFX00582.1 - 0.2 10.1 0.5 0.32 9.5 0.3 1.2 1 0 0 1 1 1 0 Poxvirus G7-like AAA_23 PF13476.1 EFX00582.1 - 0.25 11.6 8.7 0.39 11.0 6.0 1.2 1 0 0 1 1 1 0 AAA domain SprA-related PF12118.3 EFX00582.1 - 0.29 10.4 40.3 0.039 13.2 19.1 2.3 2 0 0 2 2 2 0 SprA-related family DUF4175 PF13779.1 EFX00582.1 - 0.3 8.7 33.4 0.47 8.0 23.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF912 PF06024.7 EFX00582.1 - 0.8 9.7 9.0 12 6.0 4.8 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3292 PF11696.3 EFX00582.1 - 1.1 7.0 7.7 0.86 7.3 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) Nucleo_P87 PF07267.6 EFX00582.1 - 1.4 7.5 9.7 2.3 6.7 6.7 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AIF_C PF14721.1 EFX00582.1 - 1.6 8.9 10.1 2.5 8.3 4.6 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EIIBC-GUT_N PF03612.9 EFX00582.1 - 2 7.9 10.2 0.6 9.7 4.3 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Suf PF05843.9 EFX00582.1 - 2.1 8.0 18.5 0.32 10.6 9.5 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) FimP PF09766.4 EFX00582.1 - 2.2 7.2 22.9 3.6 6.5 15.9 1.2 1 0 0 1 1 1 0 Fms-interacting protein DivIC PF04977.10 EFX00582.1 - 4.5 6.8 16.7 8.8 5.8 11.5 1.5 1 0 0 1 1 1 0 Septum formation initiator Activator_LAG-3 PF11498.3 EFX00582.1 - 6.3 5.4 40.0 14 4.3 27.7 1.6 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Ctr PF04145.10 EFX00582.1 - 7 6.6 10.1 4.3 7.3 4.6 2.3 2 0 0 2 2 2 0 Ctr copper transporter family Neur_chan_memb PF02932.11 EFX00582.1 - 7.4 6.3 7.6 5.2 6.8 3.4 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region AUX_IAA PF02309.11 EFX00582.1 - 7.7 6.1 17.5 0.18 11.5 6.5 2.1 2 0 0 2 2 2 0 AUX/IAA family RR_TM4-6 PF06459.7 EFX00582.1 - 8.6 6.1 12.8 1.1 9.0 5.8 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Folate_carrier PF01770.13 EFX00582.1 - 8.9 4.7 7.0 17 3.8 4.8 1.3 1 0 0 1 1 1 0 Reduced folate carrier Pam16 PF03656.8 EFX00583.1 - 7e-34 116.3 0.0 8.6e-34 116.0 0.0 1.0 1 0 0 1 1 1 1 Pam16 Ribonuclease PF00545.15 EFX00584.1 - 0.00041 20.3 0.0 0.00061 19.8 0.0 1.4 1 0 0 1 1 1 1 ribonuclease MDM31_MDM32 PF08118.6 EFX00585.1 - 3.4e-182 606.3 0.0 4.9e-180 599.2 0.0 2.1 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins TraH_2 PF06871.6 EFX00585.1 - 0.041 13.3 0.1 0.075 12.4 0.1 1.3 1 0 0 1 1 1 0 TraH_2 Peptidase_M61 PF05299.7 EFX00585.1 - 0.15 12.0 0.3 1.5 8.7 0.1 2.6 3 0 0 3 3 3 0 M61 glycyl aminopeptidase Mito_fiss_reg PF05308.6 EFX00585.1 - 1.6 8.0 8.1 3.3 6.9 5.6 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3336 PF11815.3 EFX00587.1 - 5.6e-50 168.6 1.9 8.5e-50 168.0 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EFX00587.1 - 4e-21 75.9 4.3 7.3e-21 75.0 0.0 3.0 3 1 0 3 3 3 1 Patatin-like phospholipase WD40 PF00400.27 EFX00589.1 - 4.5e-56 184.8 16.1 1.7e-09 37.1 0.0 8.1 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EFX00589.1 - 2.2e-09 36.0 6.0 0.0049 15.0 0.0 4.2 2 1 2 4 4 4 4 Nucleoporin Nup120/160 F-box PF00646.28 EFX00589.1 - 5.4e-07 29.1 0.8 1.8e-06 27.4 0.1 2.1 1 1 1 2 2 2 1 F-box domain F-box-like PF12937.2 EFX00589.1 - 1.9e-06 27.4 0.8 5.1e-06 26.1 0.6 1.7 1 0 0 1 1 1 1 F-box-like Nucleoporin_N PF08801.6 EFX00589.1 - 0.1 11.3 0.1 1.4 7.5 0.0 2.5 1 1 1 2 2 2 0 Nup133 N terminal like BAG PF02179.11 EFX00590.1 - 2.5e-16 59.5 0.6 2.5e-16 59.5 0.4 1.9 2 0 0 2 2 2 1 BAG domain DUF3759 PF12585.3 EFX00591.1 - 5.7e-36 122.3 9.0 7e-36 122.0 6.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DSPc PF00782.15 EFX00592.1 - 5.9e-24 84.1 0.0 1.1e-21 76.8 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFX00592.1 - 0.00062 19.1 0.0 0.00098 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF2985 PF11204.3 EFX00594.1 - 6e-36 122.0 0.4 9.9e-36 121.3 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Ras PF00071.17 EFX00595.1 - 7.2e-33 113.2 0.0 9.4e-33 112.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX00595.1 - 1.5e-14 54.4 0.0 2e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX00595.1 - 3.4e-10 39.4 0.0 6.3e-10 38.5 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFX00595.1 - 1.2e-05 25.2 0.0 2.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFX00595.1 - 1.4e-05 24.6 0.0 0.00089 18.7 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFX00595.1 - 0.00064 18.9 0.0 0.001 18.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EFX00595.1 - 0.0011 18.1 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 EFX00595.1 - 0.05 13.0 0.1 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.15 EFX00595.1 - 0.053 12.1 0.0 5.3 5.6 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.13 EFX00595.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B Fungal_trans PF04082.13 EFX00596.1 - 2e-15 56.3 0.0 4.6e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain 4HBT PF03061.17 EFX00596.1 - 0.00028 20.9 0.8 0.0054 16.8 0.4 2.5 1 1 1 2 2 2 1 Thioesterase superfamily Zn_clus PF00172.13 EFX00596.1 - 0.16 11.8 11.7 1.8 8.5 8.1 2.2 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF605 PF04652.11 EFX00596.1 - 4.7 6.4 41.1 0.96 8.7 2.5 3.2 3 0 0 3 3 3 0 Vta1 like Radical_SAM PF04055.16 EFX00598.1 - 2.4e-13 50.6 0.3 6.7e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 EFX00598.1 - 1.5e-12 47.3 0.1 6.5e-12 45.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Ribosomal_L1 PF00687.16 EFX00599.1 - 2.3e-28 99.0 0.0 2.8e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family NACHT PF05729.7 EFX00600.1 - 0.085 12.5 0.0 0.55 9.8 0.0 2.3 2 0 0 2 2 2 0 NACHT domain O-FucT PF10250.4 EFX00601.1 - 6.3e-09 35.4 0.0 0.0001 21.5 0.0 2.2 2 0 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase LRR_4 PF12799.2 EFX00602.1 - 2.2e-37 126.0 22.4 6.4e-07 28.8 0.5 9.4 8 1 1 9 9 9 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX00602.1 - 9e-32 108.6 24.6 4.5e-06 26.3 0.5 8.4 6 2 3 9 9 9 8 Leucine rich repeat LRR_1 PF00560.28 EFX00602.1 - 1.6e-13 48.6 38.5 1.4 9.2 0.0 15.5 16 2 1 17 17 17 6 Leucine Rich Repeat LRR_7 PF13504.1 EFX00602.1 - 4.5e-09 35.0 25.1 0.93 9.9 0.0 12.9 15 0 0 15 15 15 3 Leucine rich repeat LRR_6 PF13516.1 EFX00602.1 - 2.8e-07 29.9 24.7 0.27 11.4 0.1 11.1 14 0 0 14 14 14 3 Leucine Rich repeat LRR_9 PF14580.1 EFX00602.1 - 0.031 13.8 5.7 8.5 5.9 0.1 4.0 2 1 2 4 4 4 0 Leucine-rich repeat Pyr_redox_3 PF13738.1 EFX00603.1 - 6.4e-22 78.6 0.1 1.2e-21 77.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX00603.1 - 1e-13 50.4 0.0 2.6e-13 49.0 0.0 1.6 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX00603.1 - 6.2e-10 38.9 0.2 8.7e-09 35.2 0.0 3.0 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX00603.1 - 4.6e-08 32.3 0.2 1.3e-06 27.6 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFX00603.1 - 2.9e-07 30.5 0.0 5.7e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX00603.1 - 0.00089 19.0 6.1 0.061 13.0 0.0 4.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFX00603.1 - 0.0038 17.5 0.9 4.9 7.6 0.1 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX00603.1 - 0.023 13.6 7.4 0.054 12.3 0.2 2.9 2 2 1 3 3 3 0 FAD dependent oxidoreductase DUF1902 PF08972.6 EFX00603.1 - 0.047 13.2 2.3 0.12 11.9 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) Thi4 PF01946.12 EFX00603.1 - 0.18 10.8 0.0 0.8 8.7 0.0 1.9 2 0 0 2 2 2 0 Thi4 family LRR_4 PF12799.2 EFX00604.1 - 1.6e-15 56.3 9.9 1.5e-06 27.7 0.9 4.1 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX00604.1 - 5.6e-14 51.6 30.2 1e-07 31.6 3.1 3.0 1 1 4 5 5 5 5 Leucine rich repeat LRR_1 PF00560.28 EFX00604.1 - 9.5e-11 40.2 7.2 0.25 11.5 0.0 6.2 5 1 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 EFX00604.1 - 3.2e-05 23.4 8.1 13 6.5 0.0 5.9 6 0 0 6 6 6 1 Leucine rich repeat LRR_6 PF13516.1 EFX00604.1 - 0.0011 18.8 8.8 2.5 8.4 0.1 5.3 5 0 0 5 5 5 1 Leucine Rich repeat PAT1 PF09770.4 EFX00604.1 - 0.85 7.7 6.8 1.3 7.1 4.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Fungal_trans PF04082.13 EFX00605.1 - 4.5e-18 65.0 0.0 1e-17 63.8 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX00605.1 - 1.6 8.6 15.1 0.51 10.2 8.3 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.24 EFX00607.1 - 1.6e-32 112.3 0.0 2.6e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX00607.1 - 1.5e-15 56.8 0.0 3.2e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX00607.1 - 0.0024 17.7 0.0 0.0045 16.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1658 PF07871.6 EFX00607.1 - 0.014 14.9 1.8 0.72 9.5 0.5 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) PBD PF00786.23 EFX00608.1 - 0.018 15.4 1.8 0.038 14.3 0.1 2.5 3 0 0 3 3 3 0 P21-Rho-binding domain FAD_binding_3 PF01494.14 EFX00609.1 - 7.8e-18 64.6 2.5 2.3e-17 63.0 1.7 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX00609.1 - 3.6e-05 22.8 3.3 0.021 13.7 0.1 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase mRNA_cap_enzyme PF01331.14 EFX00610.1 - 8.6e-49 165.8 0.0 1.2e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 EFX00610.1 - 2.9e-19 69.3 0.1 2.6e-18 66.2 0.0 2.2 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 EFX00610.1 - 1.3e-06 27.9 0.1 0.00054 19.3 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Pox_ATPase-GT PF10640.4 EFX00610.1 - 0.18 10.5 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase Methyltransf_23 PF13489.1 EFX00611.1 - 2.8e-16 59.6 0.0 5.3e-16 58.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00611.1 - 2.7e-08 33.5 0.0 4.2e-07 29.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00611.1 - 2.9e-08 34.2 0.0 4.5e-07 30.4 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00611.1 - 2.7e-06 27.7 0.0 5.8e-06 26.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00611.1 - 5.1e-06 26.8 0.0 9.8e-05 22.7 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX00611.1 - 0.0018 18.5 0.0 0.0087 16.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX00611.1 - 0.003 16.9 0.0 0.005 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EFX00611.1 - 0.024 14.6 0.0 0.14 12.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EFX00611.1 - 0.039 13.0 0.0 0.25 10.3 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_16 PF10294.4 EFX00611.1 - 0.049 13.0 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase tRNA-synt_1b PF00579.20 EFX00612.1 - 1.1e-63 215.0 0.0 1.8e-63 214.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.17 EFX00612.1 - 8.8e-23 79.9 0.0 1.8e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Ank_5 PF13857.1 EFX00613.1 - 2.1e-08 34.1 0.1 8.9e-07 28.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX00613.1 - 0.00089 19.7 0.1 0.0079 16.6 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX00613.1 - 0.0017 18.6 0.2 0.031 14.6 0.1 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFX00613.1 - 0.15 11.8 0.4 0.52 10.2 0.3 2.0 1 0 0 1 1 1 0 Ankyrin repeat Methyltransf_23 PF13489.1 EFX00614.1 - 2.8e-19 69.3 0.0 4.3e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00614.1 - 1.4e-12 47.4 0.0 9.5e-12 44.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00614.1 - 2.2e-10 41.0 0.0 2.7e-09 37.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00614.1 - 5e-08 33.3 0.0 1.1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX00614.1 - 3e-06 27.5 0.0 7.6e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00614.1 - 5.6e-05 23.5 0.0 0.00062 20.1 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX00614.1 - 0.0033 17.4 0.0 0.012 15.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX00614.1 - 0.01 15.2 0.0 0.082 12.2 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase small domain CheR PF01739.13 EFX00614.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.12 EFX00614.1 - 0.033 13.2 0.0 0.072 12.1 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase PrmA PF06325.8 EFX00614.1 - 0.051 12.7 0.0 0.086 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.14 EFX00614.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Steroid_dh PF02544.11 EFX00617.1 - 1.1e-14 54.5 3.0 3.1e-14 52.9 2.1 1.8 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase NRDE-2 PF08424.5 EFX00619.1 - 4.4e-67 226.2 0.0 8.4e-67 225.3 0.0 1.5 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference DUF1469 PF07332.6 EFX00620.1 - 9.7 5.9 7.9 0.51 10.0 1.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) Epimerase PF01370.16 EFX00621.1 - 5.1e-23 81.7 0.0 6.7e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EFX00621.1 - 4.8e-09 35.5 0.0 7.4e-09 34.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 EFX00621.1 - 1.6e-07 31.3 0.1 3.6e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.14 EFX00621.1 - 3.1e-07 29.4 0.0 6.5e-07 28.3 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFX00621.1 - 1.5e-05 24.0 0.0 0.01 14.7 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 EFX00621.1 - 0.02 14.8 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFX00621.1 - 0.033 13.0 0.0 2.1 7.2 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Ldh_1_N PF00056.18 EFX00621.1 - 0.04 13.7 0.0 0.082 12.7 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain KR PF08659.5 EFX00621.1 - 0.043 13.4 0.1 0.091 12.4 0.0 1.7 1 1 0 1 1 1 0 KR domain ADH_N PF08240.7 EFX00622.1 - 4.9e-25 87.4 1.1 9e-25 86.5 0.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX00622.1 - 1.6e-15 56.7 1.1 2.6e-15 56.1 0.8 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX00622.1 - 2.4e-06 28.4 0.3 5e-06 27.4 0.2 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFX00622.1 - 0.0027 16.8 0.2 0.0041 16.2 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EFX00622.1 - 0.005 16.4 0.6 0.0087 15.6 0.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 EFX00622.1 - 0.011 15.4 0.6 0.011 15.4 0.4 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3437 PF11919.3 EFX00622.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) AdoHcyase_NAD PF00670.16 EFX00622.1 - 1.2 8.9 3.9 7.6 6.3 0.7 2.4 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain adh_short_C2 PF13561.1 EFX00623.1 - 8.3e-19 68.2 0.4 2.6e-18 66.6 0.3 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX00623.1 - 1.3e-16 60.9 4.0 2.1e-16 60.3 2.8 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX00623.1 - 2.1e-06 27.4 2.4 8.9e-06 25.4 1.7 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX00623.1 - 0.025 14.0 0.7 0.1 12.0 0.5 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.1 EFX00624.1 - 2.2e-10 40.5 0.1 4e-09 36.4 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX00624.1 - 3.5e-08 33.8 0.0 1.4e-07 31.9 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX00624.1 - 0.00013 21.1 0.0 0.00086 18.4 0.0 1.9 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFX00624.1 - 0.001 19.4 0.0 0.003 17.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFX00624.1 - 0.013 15.1 0.0 0.045 13.3 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_31 PF13847.1 EFX00624.1 - 0.066 12.8 0.0 0.47 10.0 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00624.1 - 0.071 13.6 0.1 5.6 7.5 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain MTS PF05175.9 EFX00624.1 - 0.12 11.7 0.0 0.85 8.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain LigB PF02900.13 EFX00625.1 - 6.7e-46 156.4 0.2 8.7e-46 156.0 0.1 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Pribosyltran PF00156.22 EFX00626.1 - 7.5e-09 35.3 0.2 3.8e-08 33.0 0.1 1.9 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Bactofilin PF04519.8 EFX00627.1 - 5.7e-06 26.2 0.6 1.7e-05 24.7 0.4 1.8 1 1 0 1 1 1 1 Polymer-forming cytoskeletal DUF342 PF03961.8 EFX00627.1 - 0.00013 20.4 4.3 0.0016 16.9 3.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF342) PAD PF03068.10 EFX00627.1 - 0.15 10.5 0.0 0.31 9.4 0.0 1.5 1 1 1 2 2 2 0 Protein-arginine deiminase (PAD) MinC_C PF03775.11 EFX00627.1 - 0.15 11.6 1.1 5.4 6.7 0.3 2.6 1 1 2 3 3 3 0 Septum formation inhibitor MinC, C-terminal domain AMP-binding PF00501.23 EFX00628.1 - 2.6e-65 220.4 0.5 3.8e-65 219.9 0.3 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX00628.1 - 7.3e-16 58.8 0.2 1.7e-15 57.6 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SART-1 PF03343.8 EFX00629.1 - 0.093 11.0 4.6 0.51 8.6 0.1 2.5 2 0 0 2 2 2 0 SART-1 family TPR_11 PF13414.1 EFX00630.1 - 1.1e-10 40.9 44.7 8.4e-05 22.1 1.9 8.7 9 2 0 9 9 8 4 TPR repeat SAM_2 PF07647.12 EFX00630.1 - 5.9e-10 38.8 0.1 1.7e-09 37.3 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_20 PF14561.1 EFX00630.1 - 7.2e-08 32.4 18.8 0.0037 17.3 0.2 6.7 6 1 0 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFX00630.1 - 4.4e-07 29.2 11.9 0.72 9.7 0.2 7.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFX00630.1 - 9.9e-07 29.2 62.3 0.00027 21.5 0.2 10.2 9 1 1 10 10 9 3 Tetratricopeptide repeat SAM_1 PF00536.25 EFX00630.1 - 4.3e-05 23.6 0.2 0.00011 22.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_14 PF13428.1 EFX00630.1 - 6.4e-05 23.2 51.8 2 9.2 0.1 12.8 11 1 1 12 12 12 4 Tetratricopeptide repeat TPR_17 PF13431.1 EFX00630.1 - 8e-05 22.5 5.1 0.45 10.8 0.0 6.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX00630.1 - 0.00045 19.6 31.3 0.33 10.6 0.0 9.0 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFX00630.1 - 0.0013 18.3 15.2 0.35 10.7 0.3 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00630.1 - 0.75 9.8 49.8 1.2 9.2 0.0 10.5 12 0 0 12 12 10 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 EFX00630.1 - 3.8 7.7 9.7 1.6 8.9 0.1 3.8 4 0 0 4 4 4 0 Alkyl sulfatase dimerisation SNF5 PF04855.7 EFX00631.1 - 1.6e-75 253.7 0.1 1.6e-75 253.7 0.0 2.1 2 0 0 2 2 2 1 SNF5 / SMARCB1 / INI1 UAA PF08449.6 EFX00632.1 - 1.5e-64 217.8 4.3 3.5e-64 216.6 3.0 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 EFX00632.1 - 3.9e-09 36.6 20.2 1.5e-07 31.5 3.2 2.6 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.10 EFX00632.1 - 2.7e-08 33.2 3.7 0.00029 20.0 0.2 2.6 3 0 0 3 3 3 2 Nucleotide-sugar transporter EmrE PF13536.1 EFX00632.1 - 2.4e-06 27.7 18.4 2.6e-05 24.3 4.5 2.8 2 1 0 2 2 2 2 Multidrug resistance efflux transporter TPT PF03151.11 EFX00632.1 - 2e-05 24.2 5.5 2e-05 24.2 3.8 2.5 2 1 0 2 2 2 2 Triose-phosphate Transporter family AAA PF00004.24 EFX00633.1 - 1.2e-39 135.5 0.0 2.3e-39 134.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX00633.1 - 3.2e-05 23.6 0.0 0.00016 21.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFX00633.1 - 0.00019 21.4 0.6 0.013 15.5 0.0 2.9 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 EFX00633.1 - 0.00029 19.9 0.0 0.00068 18.7 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFX00633.1 - 0.00056 20.0 0.5 0.02 15.0 0.0 2.7 2 1 1 3 3 2 1 AAA domain AAA_2 PF07724.9 EFX00633.1 - 0.0021 18.0 0.0 0.013 15.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) PhoH PF02562.11 EFX00633.1 - 0.0049 16.1 0.3 0.045 12.9 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.16 EFX00633.1 - 0.0068 15.5 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 EFX00633.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EFX00633.1 - 0.018 14.8 0.4 0.045 13.5 0.3 1.6 1 0 0 1 1 1 0 Part of AAA domain DUF815 PF05673.8 EFX00633.1 - 0.019 13.9 1.5 0.019 13.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 EFX00633.1 - 0.024 14.0 0.1 0.05 13.0 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.1 EFX00633.1 - 0.052 13.1 0.1 0.14 11.6 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EFX00633.1 - 0.054 12.8 1.3 0.36 10.1 0.2 2.2 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.1 EFX00633.1 - 0.095 13.5 0.1 0.095 13.5 0.0 2.7 2 2 0 2 2 2 0 AAA domain AAA_11 PF13086.1 EFX00633.1 - 0.41 10.1 2.5 0.58 9.6 0.0 2.3 2 1 1 3 3 3 0 AAA domain Glutaredoxin PF00462.19 EFX00635.1 - 3.9e-21 74.8 0.0 5.6e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin TraF PF13728.1 EFX00635.1 - 0.0011 18.5 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.1 EFX00635.1 - 0.0017 18.3 0.0 0.0029 17.5 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EFX00635.1 - 0.0018 18.4 0.1 0.0035 17.5 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain GST_N_3 PF13417.1 EFX00635.1 - 0.0094 16.1 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_9 PF14595.1 EFX00635.1 - 0.0096 15.4 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EFX00635.1 - 0.012 15.1 0.1 0.04 13.4 0.1 1.7 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin PF00085.15 EFX00635.1 - 0.016 14.8 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.9 EFX00635.1 - 0.026 14.7 0.0 0.035 14.3 0.0 1.5 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.1 EFX00635.1 - 0.053 13.5 0.3 0.2 11.6 0.1 1.8 1 1 1 2 2 2 0 Thioredoxin CBF PF03914.12 EFX00636.1 - 1.8e-26 92.5 0.0 3.8e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 CBF/Mak21 family NOC3p PF07540.6 EFX00636.1 - 5.2e-25 87.5 0.0 2.6e-24 85.3 0.0 2.2 2 0 0 2 2 2 1 Nucleolar complex-associated protein F-box-like PF12937.2 EFX00637.1 - 0.0006 19.4 0.0 0.0014 18.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX00637.1 - 0.0027 17.2 0.1 0.0085 15.7 0.1 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.2 EFX00637.1 - 0.097 12.3 3.9 1.6 8.4 0.2 3.8 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) RNA_POL_M_15KD PF02150.11 EFX00638.1 - 1.9e-10 40.2 1.7 1.9e-10 40.2 1.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit GFA PF04828.9 EFX00638.1 - 0.18 11.7 12.5 0.83 9.6 0.1 3.3 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme zf-C2H2_4 PF13894.1 EFX00639.1 - 2.2e-05 24.4 25.7 0.0015 18.7 1.3 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX00639.1 - 0.00052 20.1 2.9 0.00052 20.1 2.0 4.9 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFX00639.1 - 0.0088 16.2 3.3 0.0088 16.2 2.3 3.3 3 0 0 3 3 3 2 Zinc-finger double domain Bac_surface_Ag PF01103.18 EFX00640.1 - 1.4e-33 116.7 0.0 1.8e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Surface antigen CorA PF01544.13 EFX00643.1 - 6e-08 32.0 0.0 9e-08 31.4 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SIN1 PF05422.7 EFX00644.1 - 3.5e-32 111.6 0.0 8.4e-18 64.1 0.0 2.4 2 0 0 2 2 2 2 Stress-activated map kinase interacting protein 1 (SIN1) PRCC PF10253.4 EFX00644.1 - 2.2e-25 90.3 10.6 2.2e-25 90.3 7.3 3.3 3 1 1 4 4 4 1 Mitotic checkpoint regulator, MAD2B-interacting TUG-UBL1 PF11470.3 EFX00644.1 - 0.087 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 GLUT4 regulating protein TUG RBD PF02196.10 EFX00644.1 - 0.11 12.2 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain Nucleoplasmin PF03066.10 EFX00644.1 - 1.6 8.2 13.2 2.9 7.4 3.6 2.7 2 0 0 2 2 2 0 Nucleoplasmin Ish1 PF10281.4 EFX00645.1 - 1.6e-84 277.4 17.9 4.3e-16 58.6 0.1 8.7 9 0 0 9 9 9 8 Putative stress-responsive nuclear envelope protein SAP PF02037.22 EFX00645.1 - 3.5e-14 51.8 0.0 0.14 11.6 0.0 8.7 9 1 0 9 9 9 4 SAP domain HeH PF12949.2 EFX00645.1 - 3.5e-08 32.8 0.0 0.41 10.2 0.0 6.1 6 0 0 6 6 6 2 HeH/LEM domain Slx4 PF09494.5 EFX00645.1 - 7.5e-07 28.8 6.6 0.62 9.8 0.0 6.6 8 0 0 8 8 8 3 Slx4 endonuclease APC2 PF08672.6 EFX00645.1 - 0.0013 18.9 5.9 52 4.2 0.0 7.2 8 0 0 8 8 8 0 Anaphase promoting complex (APC) subunit 2 SAM_2 PF07647.12 EFX00645.1 - 0.22 11.3 1.2 1.2 9.0 0.0 2.9 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) Phasin PF05597.6 EFX00645.1 - 0.24 11.1 3.4 6.3 6.5 0.0 3.8 4 0 0 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Fungal_trans PF04082.13 EFX00646.1 - 7.9e-13 47.8 0.1 1.2e-12 47.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CCDC14 PF15254.1 EFX00647.1 - 0.064 11.6 0.8 0.067 11.5 0.5 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 AA_permease_2 PF13520.1 EFX00648.1 - 3.1e-46 157.7 32.0 3.8e-46 157.4 22.2 1.0 1 0 0 1 1 1 1 Amino acid permease DEAD PF00270.24 EFX00649.1 - 2.3e-43 147.5 0.0 5e-43 146.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2183 PF09949.4 EFX00649.1 - 1.2e-33 115.0 0.0 3.2e-33 113.6 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Helicase_C PF00271.26 EFX00649.1 - 9e-24 83.1 0.0 2.8e-23 81.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 EFX00649.1 - 0.23 9.8 0.2 3.9 5.7 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1253) Ribosomal_L28e PF01778.12 EFX00650.1 - 1.7e-35 121.9 0.0 2.2e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family adh_short PF00106.20 EFX00652.1 - 7.5e-22 78.0 1.4 3.1e-13 49.9 0.5 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EFX00652.1 - 4.3e-12 46.0 0.3 7.8e-08 32.1 0.3 2.3 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.1 EFX00652.1 - 3.1e-05 23.8 0.0 0.00021 21.1 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFX00652.1 - 7.1e-05 22.8 0.6 0.00015 21.8 0.4 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFX00652.1 - 0.00017 21.1 1.3 0.00059 19.3 0.9 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EFX00652.1 - 0.00017 20.9 0.3 0.0006 19.1 0.2 1.8 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.10 EFX00652.1 - 0.0014 17.5 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 EFX00652.1 - 0.018 13.9 0.0 0.043 12.7 0.0 1.6 1 1 0 1 1 1 0 RmlD substrate binding domain F420_oxidored PF03807.12 EFX00652.1 - 0.053 13.9 0.3 0.12 12.8 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Mg_trans_NIPA PF05653.9 EFX00654.1 - 9.1e-66 221.8 4.4 6.9e-63 212.3 2.1 2.3 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 EFX00654.1 - 0.0032 17.6 1.0 0.0032 17.6 0.7 3.6 3 1 0 3 3 3 1 Multidrug resistance efflux transporter DUF1183 PF06682.7 EFX00654.1 - 0.0053 16.4 5.9 0.01 15.4 4.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) DUF914 PF06027.7 EFX00654.1 - 0.016 14.1 2.3 0.24 10.2 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 EFX00654.1 - 0.018 15.1 2.1 0.018 15.1 1.5 4.3 3 1 1 4 4 4 0 EamA-like transporter family Mucin PF01456.12 EFX00654.1 - 0.037 13.8 9.5 0.11 12.3 6.6 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_S8e PF01201.17 EFX00655.1 - 1.8e-31 109.0 12.3 5.8e-31 107.3 8.5 1.8 1 1 0 1 1 1 1 Ribosomal protein S8e Cofilin_ADF PF00241.15 EFX00655.1 - 2e-13 50.3 0.0 9.1e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Aminotran_1_2 PF00155.16 EFX00656.1 - 7.6e-77 258.7 0.0 1.1e-76 258.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFX00656.1 - 0.00011 21.0 0.0 0.00023 20.0 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EFX00656.1 - 0.00013 20.4 0.0 0.00021 19.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF3405 PF11885.3 EFX00656.1 - 0.021 13.0 0.2 0.031 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) HALZ PF02183.13 EFX00657.1 - 0.33 10.7 3.4 11 5.8 0.1 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper zf-Mss51 PF13824.1 EFX00658.1 - 1.5e-28 98.4 4.9 2.8e-28 97.5 3.4 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.13 EFX00658.1 - 0.0031 17.3 0.2 0.0031 17.3 0.2 1.9 2 0 0 2 2 2 1 MYND finger GFA PF04828.9 EFX00658.1 - 0.062 13.2 1.7 0.53 10.2 0.1 2.4 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme p450 PF00067.17 EFX00659.1 - 1e-70 238.5 0.0 1.3e-70 238.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 2-Hacid_dh_C PF02826.14 EFX00660.1 - 4.4e-34 117.1 0.0 1.2e-24 86.3 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sugar_tr PF00083.19 EFX00660.1 - 4.1e-15 55.2 2.9 5.8e-07 28.4 0.0 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFX00660.1 - 0.0012 17.6 4.6 0.076 11.7 0.1 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4045 PF13254.1 EFX00662.1 - 4e-62 210.8 33.8 1.6e-35 123.2 16.9 5.3 3 3 1 4 4 4 2 Domain of unknown function (DUF4045) Gelsolin PF00626.17 EFX00662.1 - 2e-08 33.7 0.1 0.0015 18.1 0.0 2.9 3 0 0 3 3 3 2 Gelsolin repeat DUF3594 PF12165.3 EFX00663.1 - 0.06 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3594) zf-CCHC PF00098.18 EFX00664.1 - 0.0014 18.4 4.3 0.0022 17.8 3.0 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 EFX00664.1 - 0.35 10.5 1.9 0.84 9.3 1.3 1.6 1 0 0 1 1 1 0 Zinc knuckle Chalcone PF02431.10 EFX00665.1 - 1.4e-57 194.3 0.0 1.7e-57 194.0 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase Erf4 PF10256.4 EFX00666.1 - 3.1e-25 88.3 0.0 5.7e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family adh_short PF00106.20 EFX00667.1 - 8.2e-24 84.3 3.4 6.1e-23 81.5 2.4 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX00667.1 - 1.1e-10 41.7 0.0 1.7e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX00667.1 - 1.8e-09 37.4 4.7 1.3e-08 34.7 1.1 2.5 2 1 0 2 2 2 1 KR domain NAD_binding_10 PF13460.1 EFX00667.1 - 1.1e-07 32.0 0.0 3e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFX00667.1 - 2.4e-05 23.8 0.1 8.9e-05 22.0 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFX00667.1 - 0.0026 16.5 0.0 0.0035 16.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EFX00667.1 - 0.011 14.5 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Pyr_redox PF00070.22 EFX00667.1 - 0.15 12.4 0.4 0.96 9.8 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Hydrolase_6 PF13344.1 EFX00668.1 - 2.5e-27 94.7 0.0 5.6e-27 93.5 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX00668.1 - 5.2e-12 45.3 0.2 2.4e-11 43.1 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 EFX00668.1 - 1.6e-10 41.7 0.0 8.1e-10 39.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX00668.1 - 3e-05 24.3 0.0 0.0055 16.9 0.0 2.6 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase Peptidase_M13_N PF05649.8 EFX00669.1 - 2.8e-81 273.5 0.0 3.7e-81 273.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.16 EFX00669.1 - 6.5e-56 188.7 0.0 1.1e-55 188.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 zf-HC5HC2H_2 PF13832.1 EFX00670.1 - 1.2e-33 115.3 7.2 1.2e-33 115.3 5.0 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFX00670.1 - 1e-25 89.7 6.6 1e-25 89.7 4.5 2.8 3 0 0 3 3 3 1 PHD-like zinc-binding domain EPL1 PF10513.4 EFX00670.1 - 3e-18 66.5 0.0 1.7e-17 64.0 0.1 2.2 2 0 0 2 2 2 1 Enhancer of polycomb-like PHD_2 PF13831.1 EFX00670.1 - 1.3e-14 53.2 1.8 1.3e-14 53.2 1.3 2.0 2 0 0 2 2 2 1 PHD-finger PHD PF00628.24 EFX00670.1 - 4.8e-08 32.5 26.7 7.1e-08 32.0 6.7 2.8 3 0 0 3 3 3 2 PHD-finger zf-RING-like PF08746.6 EFX00670.1 - 8 6.5 21.9 0.31 11.0 3.7 2.7 2 0 0 2 2 2 0 RING-like domain CoA_binding PF02629.14 EFX00671.1 - 1.2e-27 96.2 4.2 5.4e-27 94.1 0.5 2.3 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 EFX00671.1 - 1.4e-23 83.1 0.3 2.1e-23 82.6 0.2 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 EFX00671.1 - 2.1e-08 33.8 0.1 4.1e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EFX00671.1 - 0.0009 19.3 0.0 0.0024 18.0 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain SGL PF08450.7 EFX00672.1 - 1.5e-59 201.4 0.0 1.9e-59 201.0 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region PD40 PF07676.7 EFX00672.1 - 0.11 12.2 0.3 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Amidohydro_4 PF13147.1 EFX00673.1 - 1e-23 84.7 16.7 1.6e-23 84.1 11.6 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EFX00673.1 - 1.3e-15 57.9 0.0 2.2e-14 53.8 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EFX00673.1 - 2.9e-14 52.6 1.0 3.1e-13 49.3 0.2 2.9 3 0 0 3 3 3 1 Amidohydrolase Urease_alpha PF00449.15 EFX00673.1 - 0.012 15.7 0.2 0.032 14.3 0.2 1.7 2 0 0 2 2 2 0 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.6 EFX00673.1 - 0.014 14.6 6.5 1.5 7.9 1.7 2.9 2 1 0 2 2 2 0 Amidohydrolase family Pkinase PF00069.20 EFX00674.1 - 5.6e-69 232.1 0.0 6.8e-69 231.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00674.1 - 1.3e-37 129.3 0.0 1.7e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00674.1 - 2.3e-07 30.0 0.0 3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF2046 PF09755.4 EFX00675.1 - 0.046 12.6 0.4 0.64 8.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) PV-1 PF06637.6 EFX00675.1 - 0.55 8.7 7.0 0.024 13.2 0.5 1.8 2 0 0 2 2 2 0 PV-1 protein (PLVAP) DivIC PF04977.10 EFX00675.1 - 2.1 7.9 3.6 1.1 8.7 0.3 2.0 2 0 0 2 2 2 0 Septum formation initiator SelP_N PF04592.9 EFX00675.1 - 3 7.1 15.0 5.5 6.3 4.2 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DivIVA PF05103.8 EFX00675.1 - 7.3 6.6 6.4 1.8 8.6 1.2 2.0 2 0 0 2 2 2 0 DivIVA protein GCD14 PF08704.5 EFX00676.1 - 6.5e-65 219.0 0.0 2.6e-61 207.2 0.0 2.1 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_26 PF13659.1 EFX00676.1 - 0.00063 19.7 0.0 0.0023 17.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX00676.1 - 0.0041 17.6 0.0 0.0074 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF3425 PF11905.3 EFX00677.1 - 9.1e-13 48.2 0.1 1e-11 44.8 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF3425) RNA_GG_bind PF10258.4 EFX00677.1 - 0.12 12.0 0.2 0.65 9.7 0.1 2.1 2 0 0 2 2 2 0 PHAX RNA-binding domain bZIP_1 PF00170.16 EFX00677.1 - 0.14 12.1 8.5 0.11 12.4 1.2 2.3 2 0 0 2 2 2 0 bZIP transcription factor Hap4_Hap_bind PF10297.4 EFX00678.1 - 3.1e-09 36.3 7.1 6.7e-09 35.2 4.9 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.16 EFX00678.1 - 0.00014 21.7 8.7 0.00014 21.7 6.0 2.8 2 1 1 3 3 3 2 bZIP transcription factor HAUS6_N PF14661.1 EFX00678.1 - 0.028 13.7 3.0 0.046 13.0 2.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus PspB PF06667.7 EFX00678.1 - 0.073 13.0 1.2 0.16 11.9 0.7 1.6 1 1 0 1 1 1 0 Phage shock protein B Fmp27_WPPW PF10359.4 EFX00678.1 - 1.1 7.6 4.9 1.6 7.0 3.4 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain bZIP_2 PF07716.10 EFX00678.1 - 1.4 8.7 18.7 1 9.1 7.9 2.7 2 1 1 3 3 3 0 Basic region leucine zipper MFS_1 PF07690.11 EFX00679.1 - 3.8e-34 117.9 30.2 4.6e-34 117.6 20.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Syndecan PF01034.15 EFX00679.1 - 0.0011 18.5 1.7 0.0043 16.6 0.0 2.7 2 0 0 2 2 2 1 Syndecan domain ESSS PF10183.4 EFX00679.1 - 0.079 13.3 0.1 0.22 11.9 0.1 1.7 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) PepSY_TM_3 PF13706.1 EFX00679.1 - 0.69 9.3 4.8 0.36 10.2 0.7 2.6 2 0 0 2 2 2 0 PepSY-associated TM helix Sugar_tr PF00083.19 EFX00680.1 - 1.3e-99 333.8 22.2 3.2e-98 329.2 15.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX00680.1 - 3e-20 72.2 47.9 1.8e-17 63.0 10.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily TPR_9 PF13371.1 EFX00680.1 - 0.3 10.9 1.7 0.64 9.9 1.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Yip1 PF04893.12 EFX00681.1 - 2.5e-05 23.8 14.8 0.00062 19.3 4.6 2.7 2 1 1 3 3 3 2 Yip1 domain ADH_zinc_N PF00107.21 EFX00682.1 - 1.1e-11 44.3 0.1 2.3e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX00682.1 - 1.7e-07 30.9 0.3 1.7e-06 27.7 0.1 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EFX00682.1 - 0.018 15.9 0.4 0.059 14.2 0.3 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase RRM_1 PF00076.17 EFX00684.1 - 5.3e-08 32.3 0.0 1.2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX00684.1 - 4.5e-06 26.5 0.0 1.1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFX00684.1 - 8.3e-06 25.4 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF1996 PF09362.5 EFX00685.1 - 3.8e-62 210.0 0.1 3.8e-62 210.0 0.1 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF1996) DUF605 PF04652.11 EFX00685.1 - 3 7.1 26.6 4.6 6.5 18.5 1.2 1 0 0 1 1 1 0 Vta1 like PHD PF00628.24 EFX00686.1 - 5.7e-11 41.9 3.3 9.4e-11 41.2 2.3 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.2 EFX00686.1 - 0.014 15.6 0.0 0.014 15.6 0.0 2.8 1 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding XendoU PF09412.5 EFX00686.1 - 0.081 11.9 1.4 0.16 10.9 0.9 1.4 1 0 0 1 1 1 0 Endoribonuclease XendoU DUF4238 PF14022.1 EFX00686.1 - 0.18 11.0 1.2 0.33 10.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) LMBR1 PF04791.11 EFX00686.1 - 0.65 8.5 2.2 1.5 7.3 1.6 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_23 PF13476.1 EFX00686.1 - 1.9 8.8 10.2 0.8 9.9 3.8 2.1 2 0 0 2 2 2 0 AAA domain PXA PF02194.10 EFX00686.1 - 3.8 7.0 7.0 0.83 9.1 1.5 2.1 2 0 0 2 2 2 0 PXA domain Pept_tRNA_hydro PF01195.14 EFX00688.1 - 3.4e-29 101.6 0.0 3.8e-29 101.4 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase DAO PF01266.19 EFX00689.1 - 1.2e-46 159.2 7.8 1.6e-46 158.8 5.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX00689.1 - 0.0082 16.2 0.0 0.42 10.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX00689.1 - 0.012 15.6 0.3 0.012 15.6 0.2 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFX00689.1 - 0.066 11.6 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.1 EFX00689.1 - 0.089 12.5 1.7 1.2 8.8 0.1 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Sulfotransfer_3 PF13469.1 EFX00691.1 - 1e-05 26.5 3.8 1.6e-05 25.8 2.6 1.3 1 0 0 1 1 1 1 Sulfotransferase family VirE PF05272.6 EFX00691.1 - 0.074 12.5 0.3 0.2 11.0 0.2 1.6 2 0 0 2 2 2 0 Virulence-associated protein E Nuc_sug_transp PF04142.10 EFX00692.1 - 4.2e-09 35.8 2.0 6.3e-09 35.2 0.8 1.7 2 0 0 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 EFX00692.1 - 0.00077 19.5 25.7 0.0023 17.9 4.5 3.3 2 1 1 3 3 3 3 EamA-like transporter family WBS28 PF15164.1 EFX00692.1 - 0.018 14.1 6.7 0.011 14.9 2.3 2.0 1 1 1 2 2 2 0 Williams-Beuren syndrome chromosomal region 28 protein homologue EmrE PF13536.1 EFX00692.1 - 0.018 15.2 5.2 0.018 15.2 3.6 3.3 3 1 1 4 4 4 0 Multidrug resistance efflux transporter Phosphoesterase PF04185.9 EFX00693.1 - 4.9e-63 213.5 1.4 8.1e-63 212.8 0.9 1.3 1 1 0 1 1 1 1 Phosphoesterase family Inhibitor_I78 PF11720.3 EFX00694.1 - 2.4e-08 33.5 0.0 3.2e-08 33.1 0.0 1.3 1 1 0 1 1 1 1 Peptidase inhibitor I78 family DUF1485 PF07364.7 EFX00695.1 - 4.6e-76 255.8 2.0 6.4e-76 255.3 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1485) MlrC_C PF07171.7 EFX00695.1 - 1.1e-41 142.3 0.0 1.1e-41 142.3 0.0 1.9 3 0 0 3 3 3 1 MlrC C-terminus DnaJ PF00226.26 EFX00696.1 - 8.8e-15 54.2 0.2 1.5e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.13 EFX00697.1 - 9.2e-11 41.0 0.3 1.8e-10 40.1 0.2 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX00697.1 - 2.1e-10 40.3 10.6 4.1e-10 39.4 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DLH PF01738.13 EFX00698.1 - 5.7e-10 38.8 0.0 7.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Bac_rhamnosid PF05592.6 EFX00699.1 - 1.5e-188 627.1 0.0 1.8e-188 626.8 0.0 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase Bac_rhamnosid_N PF08531.5 EFX00699.1 - 1.4e-56 190.7 0.6 4.1e-56 189.2 0.0 2.1 2 0 0 2 2 2 1 Alpha-L-rhamnosidase N-terminal domain Phage_base_V PF04717.7 EFX00699.1 - 0.0035 17.2 1.3 2.5 8.1 0.2 3.5 2 0 0 2 2 2 2 Phage-related baseplate assembly protein Glyco_hydro_2_N PF02837.13 EFX00699.1 - 0.017 14.7 0.0 0.039 13.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain Stb3 PF10330.4 EFX00700.1 - 2.4e-31 107.2 0.0 4.1e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein AA_kinase PF00696.23 EFX00702.1 - 5.6e-39 134.1 0.4 8.1e-39 133.6 0.3 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 EFX00702.1 - 5.4e-17 61.2 0.8 3.8e-16 58.5 0.1 2.4 2 0 0 2 2 2 1 PUA domain NYD-SP28_assoc PF14775.1 EFX00702.1 - 0.21 11.3 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 Sperm tail C-terminal domain Scs3p PF10261.4 EFX00703.1 - 3.2e-47 160.5 0.2 1.3e-46 158.6 0.2 1.8 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM BMC PF00936.14 EFX00703.1 - 0.034 13.8 2.6 0.045 13.4 0.2 2.2 2 0 0 2 2 2 0 BMC domain Chorion_2 PF03964.10 EFX00703.1 - 0.13 12.7 5.7 15 6.2 2.7 2.6 2 0 0 2 2 2 0 Chorion family 2 MBOAT PF03062.14 EFX00706.1 - 3.4e-19 69.1 13.4 3.4e-19 69.1 9.3 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EFX00706.1 - 9e-05 22.4 3.5 0.00037 20.5 2.4 2.1 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family F-box-like PF12937.2 EFX00708.1 - 2e-13 49.8 0.6 5.2e-13 48.4 0.4 1.8 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 EFX00708.1 - 1.1e-11 43.4 8.2 7.9 6.8 0.0 10.4 11 0 0 11 11 11 2 Leucine Rich repeat LRR_4 PF12799.2 EFX00708.1 - 1e-07 31.3 0.5 0.95 9.1 0.0 5.9 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFX00708.1 - 0.00015 21.2 17.9 7.4 7.0 0.2 9.1 7 3 0 7 7 7 1 Leucine Rich Repeat F-box PF00646.28 EFX00708.1 - 0.00016 21.2 1.4 0.0003 20.3 0.1 2.2 2 0 0 2 2 2 1 F-box domain LRR_8 PF13855.1 EFX00708.1 - 0.00024 20.8 8.2 1.8 8.3 0.0 5.1 4 2 2 6 6 6 5 Leucine rich repeat DUF1699 PF08004.6 EFX00708.1 - 0.09 12.2 0.2 14 5.2 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1699) ACC_central PF08326.7 EFX00709.1 - 2.4e-244 812.7 0.0 3.2e-244 812.3 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 EFX00709.1 - 3.1e-175 583.2 0.0 4.2e-175 582.8 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 EFX00709.1 - 1.7e-52 177.7 0.0 3e-52 176.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EFX00709.1 - 1.1e-23 83.3 0.1 2.3e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EFX00709.1 - 4.7e-20 71.5 0.0 1.2e-18 67.0 0.0 2.7 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 EFX00709.1 - 5.5e-17 61.1 0.1 1.3e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 EFX00709.1 - 1.8e-10 40.8 0.0 6.9e-10 38.9 0.0 2.0 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EFX00709.1 - 3.2e-07 29.4 0.0 5e-05 22.1 0.0 3.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFX00709.1 - 0.0012 18.2 0.0 0.0025 17.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.1 EFX00709.1 - 0.0048 16.5 0.0 0.017 14.7 0.0 1.9 2 0 0 2 2 1 1 Biotin-lipoyl like ATP-grasp_3 PF02655.9 EFX00709.1 - 0.009 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 EFX00709.1 - 0.025 13.9 0.0 0.062 12.6 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain HlyD_2 PF12700.2 EFX00709.1 - 0.32 10.1 0.0 0.63 9.1 0.0 1.4 1 0 0 1 1 1 0 HlyD family secretion protein Rad60-SLD PF11976.3 EFX00710.1 - 4.9e-21 74.1 0.4 8.3e-21 73.4 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EFX00710.1 - 0.023 14.0 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Methyltransf_16 PF10294.4 EFX00712.1 - 2.2e-29 102.1 0.0 3.4e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 EFX00712.1 - 0.0011 18.7 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FAM220 PF15487.1 EFX00712.1 - 0.088 12.1 1.1 0.14 11.4 0.8 1.2 1 0 0 1 1 1 0 FAM220 family SGS PF05002.10 EFX00713.1 - 0.023 14.4 2.9 0.029 14.1 0.6 2.2 2 0 0 2 2 2 0 SGS domain MFS_1 PF07690.11 EFX00714.1 - 4.7e-28 97.9 38.7 7.3e-28 97.2 22.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX00714.1 - 7.3e-07 28.1 7.0 7.3e-07 28.1 4.8 2.4 1 1 0 2 2 2 1 Sugar (and other) transporter DUF1228 PF06779.9 EFX00714.1 - 0.011 15.7 0.4 0.011 15.7 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1228) HgmA PF04209.8 EFX00715.1 - 4.1e-156 519.6 0.0 5.2e-156 519.2 0.0 1.1 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase PAPS_reduct PF01507.14 EFX00716.1 - 8.6e-28 97.3 0.0 2.1e-20 73.2 0.0 2.3 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family UCH PF00443.24 EFX00717.1 - 1.4e-43 148.9 0.1 3.9e-43 147.5 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX00717.1 - 1.1e-16 61.1 2.2 5.4e-15 55.6 0.6 3.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF3517 PF12030.3 EFX00717.1 - 5.7e-14 51.4 0.0 1.1e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) DUF2457 PF10446.4 EFX00719.1 - 0.063 11.9 0.6 2.2 6.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) NAD_binding_2 PF03446.10 EFX00720.1 - 1.5e-29 102.9 0.1 2.7e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFX00720.1 - 5.9e-25 87.6 1.5 2.5e-13 50.1 0.0 2.5 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 EFX00720.1 - 4.8e-06 26.8 0.2 1.5e-05 25.2 0.2 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 EFX00720.1 - 0.0022 17.6 0.7 0.0022 17.6 0.5 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 EFX00720.1 - 0.01 15.2 0.1 1.4 8.2 0.0 2.3 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.11 EFX00720.1 - 0.14 11.5 0.8 0.41 10.0 0.1 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Runt PF00853.14 EFX00722.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Runt domain bZIP_1 PF00170.16 EFX00723.1 - 4e-06 26.6 7.0 7.1e-06 25.8 4.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX00723.1 - 0.1 12.4 5.9 0.21 11.4 4.1 1.5 1 0 0 1 1 1 0 Basic region leucine zipper GvpL_GvpF PF06386.6 EFX00723.1 - 0.14 11.7 2.3 0.2 11.2 1.6 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF4407 PF14362.1 EFX00723.1 - 0.54 9.1 2.2 0.9 8.4 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_M76 PF09768.4 EFX00724.1 - 8.4e-66 220.6 1.5 6.7e-65 217.7 1.1 2.0 1 1 0 1 1 1 1 Peptidase M76 family DUF1660 PF07874.6 EFX00724.1 - 0.61 10.4 5.0 8.5 6.7 1.1 2.8 1 1 1 2 2 2 0 Prophage protein (DUF1660) SprT-like PF10263.4 EFX00724.1 - 0.64 9.6 6.0 0.16 11.5 1.8 1.8 1 1 1 2 2 2 0 SprT-like family AMP-binding PF00501.23 EFX00725.1 - 6.9e-45 153.1 0.0 9.3e-45 152.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX00725.1 - 4.8e-05 24.2 0.0 0.00012 22.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MMS19_C PF12460.3 EFX00725.1 - 0.28 9.8 0.0 9.8 4.7 0.0 2.0 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal zf-C2H2 PF00096.21 EFX00727.1 - 2.3e-24 84.1 49.1 0.00028 21.0 0.3 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX00727.1 - 1.1e-18 66.1 54.0 0.00096 19.3 0.6 10.2 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX00727.1 - 4.6e-13 48.7 46.2 5.6e-05 23.2 0.3 9.9 11 0 0 11 11 11 5 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EFX00727.1 - 1.9e-06 27.8 28.7 1.1 9.4 0.3 9.4 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX00727.1 - 0.00081 19.5 21.8 5.6 7.3 0.1 7.6 9 0 0 9 9 9 3 Zinc-finger of C2H2 type zf-Di19 PF05605.7 EFX00727.1 - 0.0094 16.0 1.5 0.0094 16.0 1.0 6.8 7 1 0 7 7 7 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 EFX00727.1 - 5.4 7.0 18.7 6.6 6.7 0.3 6.1 7 0 0 7 7 7 0 C2H2-type zinc finger Glyco_hydro_1 PF00232.13 EFX00728.1 - 2.3e-150 500.7 0.0 2.8e-150 500.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 ABC1 PF03109.11 EFX00730.1 - 3e-23 82.0 0.0 6.3e-14 51.9 0.0 2.5 2 0 0 2 2 2 2 ABC1 family APH PF01636.18 EFX00730.1 - 0.011 15.4 3.6 0.016 14.9 0.4 2.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 EFX00730.1 - 0.017 14.4 0.0 0.045 13.0 0.0 1.6 1 0 0 1 1 1 0 RIO1 family BSP_II PF05432.6 EFX00731.1 - 3.9 6.6 13.7 1 8.5 6.0 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) DUF533 PF04391.7 EFX00732.1 - 0.019 14.3 0.1 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Rax2 PF12768.2 EFX00732.1 - 0.029 13.6 0.0 0.04 13.1 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity CDC37_N PF03234.9 EFX00733.1 - 1.9e-54 184.6 0.4 1.9e-54 184.6 0.3 2.1 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 EFX00733.1 - 9.9e-30 103.2 0.0 9.9e-30 103.2 0.0 1.8 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 EFX00733.1 - 1.9e-19 69.3 4.7 4.3e-19 68.2 0.5 2.9 2 1 1 3 3 3 1 Cdc37 C terminal domain PPR_3 PF13812.1 EFX00733.1 - 0.051 13.8 0.2 38 4.9 0.0 3.9 3 1 0 3 3 3 0 Pentatricopeptide repeat domain DUF1268 PF06896.6 EFX00733.1 - 0.052 13.8 0.6 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1268) SNF2_N PF00176.18 EFX00734.1 - 3.1e-48 164.1 0.1 4.4e-47 160.3 0.1 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX00734.1 - 4.9e-14 51.9 0.0 3.4e-13 49.2 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Acyltransferase PF01553.16 EFX00735.1 - 6.9e-27 93.4 0.0 2.2e-26 91.8 0.0 1.7 2 0 0 2 2 2 1 Acyltransferase Peptidase_M24 PF00557.19 EFX00736.1 - 8.2e-43 146.3 0.0 1.4e-42 145.5 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 EFX00736.1 - 1.5e-23 83.7 0.1 4.3e-18 66.0 0.0 3.1 4 0 0 4 4 4 2 Creatinase/Prolidase N-terminal domain Phytochelatin_C PF09328.5 EFX00737.1 - 0.15 11.4 0.7 0.17 11.3 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) SET PF00856.23 EFX00738.1 - 1.8e-08 34.8 0.0 5.9e-08 33.1 0.0 1.9 1 0 0 1 1 1 1 SET domain Ribosomal_L24e PF01246.15 EFX00739.1 - 4.9e-32 109.6 3.1 9e-32 108.7 2.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L24e TFIIA PF03153.8 EFX00739.1 - 0.012 15.4 1.2 0.012 15.5 0.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3602 PF12223.3 EFX00740.1 - 4.2e-12 46.2 9.7 2.9e-05 24.3 0.6 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) DUF780 PF05611.6 EFX00740.1 - 0.58 10.9 6.8 1.6 9.4 0.5 2.7 3 0 0 3 3 3 0 Caenorhabditis elegans protein of unknown function (DUF780) Med10 PF09748.4 EFX00741.1 - 6.9e-33 113.2 0.0 9.3e-33 112.7 0.0 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Fungal_trans_2 PF11951.3 EFX00742.1 - 0.01 14.4 1.3 0.012 14.2 0.1 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain DUF2057 PF09829.4 EFX00742.1 - 0.49 10.0 3.1 0.98 9.0 2.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) RCC1 PF00415.13 EFX00743.1 - 4.4e-55 183.6 13.0 1.6e-09 37.8 0.1 8.4 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EFX00743.1 - 2.2e-42 141.8 22.9 7.8e-11 41.3 0.2 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.1 EFX00743.1 - 0.0071 15.9 0.5 0.039 13.5 0.0 2.4 3 0 0 3 3 3 1 PapC C-terminal domain FA_hydroxylase PF04116.8 EFX00745.1 - 2.4e-12 47.2 16.4 2.4e-12 47.2 11.4 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily ParA PF10609.4 EFX00746.1 - 2.4e-35 120.2 0.1 4.1e-35 119.5 0.1 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EFX00746.1 - 2.7e-16 59.5 0.0 4.9e-16 58.7 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 EFX00746.1 - 1.6e-06 27.4 0.0 3.6e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.10 EFX00746.1 - 6.4e-05 22.1 0.6 0.00012 21.2 0.4 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.1 EFX00746.1 - 0.0003 20.7 0.1 0.00091 19.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EFX00746.1 - 0.0026 16.5 0.2 0.0041 15.9 0.2 1.2 1 0 0 1 1 1 1 ArgK protein AAA_25 PF13481.1 EFX00746.1 - 0.0041 16.5 0.1 0.0071 15.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain YhjQ PF06564.7 EFX00746.1 - 0.024 14.0 0.2 0.037 13.3 0.2 1.4 1 1 0 1 1 1 0 YhjQ protein APS_kinase PF01583.15 EFX00746.1 - 0.056 13.0 0.1 0.087 12.4 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_10 PF12846.2 EFX00746.1 - 0.12 11.7 0.2 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain US22 PF02393.11 EFX00746.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 US22 like AAA_26 PF13500.1 EFX00746.1 - 0.15 11.6 0.3 12 5.4 0.4 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EFX00746.1 - 0.21 10.7 1.5 0.25 10.5 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 HK PF02110.10 EFX00747.1 - 1.5e-59 201.1 8.4 6.7e-59 199.0 5.8 2.2 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.12 EFX00747.1 - 1.8e-41 141.2 3.6 1.8e-41 141.2 2.5 2.3 3 0 0 3 3 3 1 Thiamine monophosphate synthase/TENI Zn_clus PF00172.13 EFX00747.1 - 0.019 14.9 8.4 0.033 14.0 5.8 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX00747.1 - 0.049 12.5 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain RRM_6 PF14259.1 EFX00748.1 - 0.042 13.8 0.0 0.51 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Ribonuc_L-PSP PF01042.16 EFX00749.1 - 2e-35 121.1 0.0 2.2e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF3182 PF11379.3 EFX00749.1 - 0.055 12.1 0.0 0.067 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) RabGAP-TBC PF00566.13 EFX00751.1 - 1.1e-22 80.5 0.1 1.9e-12 47.1 0.2 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain UDG PF03167.14 EFX00753.1 - 6.7e-26 90.5 0.1 1.3e-25 89.6 0.1 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily CDC27 PF09507.5 EFX00753.1 - 0.0025 17.0 55.6 0.14 11.4 32.8 2.2 2 0 0 2 2 2 2 DNA polymerase subunit Cdc27 PT PF04886.7 EFX00753.1 - 1 8.7 14.7 0.78 9.1 7.0 2.8 2 0 0 2 2 2 0 PT repeat Daxx PF03344.10 EFX00753.1 - 8.1 4.7 41.9 13 4.1 29.1 1.4 1 0 0 1 1 1 0 Daxx Family DUF3835 PF12927.2 EFX00754.1 - 8.7e-20 71.4 0.0 8.7e-20 71.4 0.0 6.8 7 1 1 8 8 8 3 Domain of unknown function (DUF3835) Prefoldin_3 PF13758.1 EFX00754.1 - 1.4e-19 69.6 0.1 5.4e-19 67.7 0.1 2.1 1 0 0 1 1 1 1 Prefoldin subunit FliT PF05400.8 EFX00754.1 - 5.2 7.5 12.0 5.5 7.4 0.0 3.8 3 1 0 3 3 3 0 Flagellar protein FliT RhoGAP PF00620.22 EFX00755.1 - 6.1e-44 149.2 0.1 1.2e-43 148.3 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.24 EFX00755.1 - 2.7e-11 43.5 0.0 5.8e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EFX00755.1 - 3.9e-07 30.3 0.0 9.6e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 EFX00755.1 - 0.026 14.5 0.0 0.1 12.6 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain VCX_VCY PF15231.1 EFX00756.1 - 0.031 14.7 16.6 0.05 14.0 1.9 2.4 2 0 0 2 2 2 0 Variable charge X/Y family LCAT PF02450.10 EFX00757.1 - 6.8e-98 328.1 0.0 8.3e-98 327.8 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.13 EFX00757.1 - 0.022 14.0 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) Abhydrolase_5 PF12695.2 EFX00757.1 - 0.056 13.1 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF1749 PF08538.5 EFX00757.1 - 0.068 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Sec23_trunk PF04811.10 EFX00758.1 - 4.9e-67 225.8 0.0 7.3e-67 225.2 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EFX00758.1 - 1.1e-23 82.6 0.0 2.7e-22 78.1 0.0 2.4 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EFX00758.1 - 4.5e-18 65.5 0.1 9.9e-18 64.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EFX00758.1 - 1.1e-17 63.2 5.5 1.9e-17 62.5 3.8 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EFX00758.1 - 2.1e-10 40.1 0.0 4.6e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Raffinose_syn PF05691.7 EFX00759.1 - 3.6e-45 153.7 0.0 9.6e-43 145.7 0.0 2.2 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.13 EFX00759.1 - 8.3e-05 21.4 0.0 0.00015 20.6 0.0 1.3 1 0 0 1 1 1 1 Melibiase Sel1 PF08238.7 EFX00760.1 - 1.5e-17 63.6 34.3 5.6e-08 33.1 0.7 7.8 7 0 0 7 7 7 5 Sel1 repeat TPR_11 PF13414.1 EFX00760.1 - 0.014 14.9 0.1 0.014 14.9 0.1 3.1 3 0 0 3 3 3 0 TPR repeat TPR_1 PF00515.23 EFX00760.1 - 0.019 14.5 5.9 0.03 13.9 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt20 PF12090.3 EFX00760.1 - 0.69 9.2 6.6 1.3 8.3 4.5 1.3 1 0 0 1 1 1 0 Spt20 family Suf PF05843.9 EFX00760.1 - 1.1 8.9 7.0 2.9 7.5 4.9 1.7 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TPR_8 PF13181.1 EFX00760.1 - 1.5 8.7 6.3 0.27 11.1 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DNA_primase_S PF01896.14 EFX00761.1 - 4.6e-53 178.9 0.0 7.8e-53 178.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Mito_carr PF00153.22 EFX00762.1 - 2.6e-60 200.1 1.9 2.6e-21 75.1 0.0 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein WD40 PF00400.27 EFX00763.1 - 1.2e-06 28.1 6.9 0.0027 17.5 0.0 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EFX00763.1 - 0.18 11.3 0.4 26 4.4 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SPX PF03105.14 EFX00764.1 - 2.6e-28 99.6 0.0 1.8e-27 96.8 0.0 2.0 1 1 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.1 EFX00764.1 - 2.8e-07 30.2 8.8 2.8e-07 30.2 6.1 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 EFX00764.1 - 8.7e-07 28.5 8.9 1.8e-06 27.5 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX00764.1 - 1.6e-06 27.6 8.4 3e-06 26.7 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX00764.1 - 1.7e-06 27.7 12.2 3.3e-06 26.8 8.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFX00764.1 - 3.2e-05 23.8 11.5 6.2e-05 22.9 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX00764.1 - 0.00056 19.5 11.0 0.0033 17.1 8.0 2.0 1 1 1 2 2 2 1 zinc-RING finger domain EB_dh PF09459.5 EFX00764.1 - 0.0084 15.5 0.1 0.02 14.3 0.0 1.5 1 1 0 1 1 1 1 Ethylbenzene dehydrogenase NOB1_Zn_bind PF08772.6 EFX00764.1 - 0.011 15.5 0.5 1.6 8.5 0.4 2.6 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DHQ_synthase PF01761.15 EFX00764.1 - 0.012 14.6 0.0 0.022 13.6 0.0 1.4 1 0 0 1 1 1 0 3-dehydroquinate synthase TerY-C PF15616.1 EFX00764.1 - 0.028 14.3 0.6 0.063 13.2 0.4 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain zf-Apc11 PF12861.2 EFX00764.1 - 0.065 13.0 3.1 0.12 12.1 2.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 EFX00764.1 - 0.07 12.8 7.7 0.17 11.6 5.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger TF_Zn_Ribbon PF08271.7 EFX00764.1 - 0.13 11.6 0.7 3.5 7.0 0.0 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zf-RING_4 PF14570.1 EFX00764.1 - 0.56 9.8 10.7 0.11 12.1 3.8 2.4 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain UCH PF00443.24 EFX00765.1 - 1.4e-35 122.7 0.0 4.8e-35 120.9 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX00765.1 - 2.7e-14 53.3 0.0 9.4e-07 28.5 0.0 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 EFX00765.1 - 1.9e-11 43.2 0.4 0.00017 20.9 0.1 2.5 2 0 0 2 2 2 2 A repeated domain in UCH-protein Kelch_4 PF13418.1 EFX00765.1 - 0.078 12.7 0.1 0.27 11.0 0.0 1.9 1 0 0 1 1 1 0 Galactose oxidase, central domain RRM_1 PF00076.17 EFX00766.1 - 1.6e-10 40.4 0.1 3.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX00766.1 - 5e-08 32.8 0.0 1e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX00766.1 - 3.6e-05 23.5 0.1 7.5e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.10 EFX00766.1 - 0.064 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain Nup35_RRM_2 PF14605.1 EFX00766.1 - 0.16 11.7 0.0 0.45 10.3 0.0 1.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif WD40 PF00400.27 EFX00767.1 - 1.5e-07 30.9 0.4 0.011 15.5 0.0 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Mito_carr PF00153.22 EFX00768.1 - 1.8e-71 235.9 5.5 6e-25 86.7 0.2 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein PPR_2 PF13041.1 EFX00769.1 - 1.5e-11 44.0 0.0 1.2e-06 28.4 0.0 3.9 3 0 0 3 3 3 2 PPR repeat family PPR PF01535.15 EFX00769.1 - 8.4e-07 28.5 5.7 0.0019 18.0 0.0 4.9 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.1 EFX00769.1 - 0.00013 22.0 12.3 0.14 12.5 0.1 7.1 7 0 0 7 7 7 1 Pentatricopeptide repeat domain DUF1727 PF08353.5 EFX00769.1 - 0.026 14.1 0.1 0.08 12.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1727) TPR_6 PF13174.1 EFX00769.1 - 5.5 7.6 9.4 37 5.0 0.6 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Lgl_C PF08596.5 EFX00770.1 - 5.4e-109 364.2 0.0 7.6e-109 363.7 0.0 1.2 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.27 EFX00770.1 - 1.5e-06 27.8 0.2 0.16 11.9 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat PQQ_2 PF13360.1 EFX00770.1 - 0.00079 18.9 0.4 0.062 12.7 0.2 2.9 1 1 1 2 2 2 2 PQQ-like domain Cyclin_N PF00134.18 EFX00771.1 - 2.6e-37 127.2 0.1 4.2e-37 126.5 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFX00771.1 - 3.2e-10 39.9 0.7 1.5e-09 37.7 0.1 2.3 2 1 0 2 2 2 1 Cyclin, C-terminal domain Prefoldin PF02996.12 EFX00772.1 - 9.1e-30 102.7 0.2 3.2e-29 101.0 0.1 1.8 1 1 0 1 1 1 1 Prefoldin subunit Filament PF00038.16 EFX00772.1 - 0.0036 16.8 1.8 1.4 8.3 0.0 2.1 2 0 0 2 2 2 2 Intermediate filament protein Prefoldin_2 PF01920.15 EFX00772.1 - 0.0036 17.0 0.4 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 Prefoldin subunit Lyase_8 PF02278.13 EFX00772.1 - 0.02 14.2 0.1 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain HR1 PF02185.11 EFX00772.1 - 0.06 13.0 0.4 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 Hr1 repeat COG6 PF06419.6 EFX00773.1 - 3.6e-176 586.9 1.0 2.4e-145 485.1 0.0 2.4 1 1 1 2 2 2 2 Conserved oligomeric complex COG6 DASH_Dad3 PF08656.5 EFX00773.1 - 0.0084 15.7 0.1 0.96 9.1 0.0 2.8 2 0 0 2 2 2 1 DASH complex subunit Dad3 RmuC PF02646.11 EFX00773.1 - 0.045 12.5 0.5 0.17 10.6 0.0 2.0 2 0 0 2 2 2 0 RmuC family COG2 PF06148.6 EFX00773.1 - 2.8 7.8 5.9 2.7 7.8 0.1 3.4 4 1 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Fungal_trans PF04082.13 EFX00774.1 - 9.1e-06 24.7 0.0 1.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX00774.1 - 3.6e-05 23.5 9.5 3.6e-05 23.5 6.6 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0029 PF01205.14 EFX00774.1 - 0.048 13.3 0.4 0.66 9.6 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein family UPF0029 zf-TRAF PF02176.13 EFX00774.1 - 1.7 9.0 7.4 4.2 7.8 0.1 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger DUF1771 PF08590.5 EFX00775.1 - 1.2e-13 50.8 10.9 2.7e-13 49.7 7.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.16 EFX00775.1 - 1.8e-09 37.6 0.0 5.2e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Smr domain zf-CCCH PF00642.19 EFX00775.1 - 0.00091 18.8 0.3 0.0017 17.9 0.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HEM4 PF02602.10 EFX00776.1 - 1.7e-34 119.0 0.0 2.1e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Vac14_Fig4_bd PF11916.3 EFX00777.1 - 1.2e-59 200.5 14.2 5.8e-33 113.5 1.9 2.6 2 1 1 3 3 3 2 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 EFX00777.1 - 6.4e-45 151.4 0.1 4e-42 142.5 0.0 4.2 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT PF02985.17 EFX00777.1 - 6.2e-08 32.0 3.8 0.0012 18.7 0.0 5.8 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 EFX00777.1 - 1.7e-07 31.4 3.5 0.00076 19.8 0.0 4.7 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 EFX00777.1 - 0.00032 20.9 3.9 0.2 11.9 0.0 4.8 5 0 0 5 5 5 1 HEAT repeats Cnd1 PF12717.2 EFX00777.1 - 0.00094 19.0 1.5 1.4 8.7 0.0 2.9 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EFX00777.1 - 0.012 15.4 0.0 6.8 6.6 0.0 4.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Cucumo_2B PF03263.8 EFX00777.1 - 0.84 9.9 3.8 0.63 10.3 0.5 2.2 2 0 0 2 2 2 0 Cucumovirus protein 2B MFS_1 PF07690.11 EFX00778.1 - 3e-39 134.7 45.9 3.8e-39 134.3 30.1 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX00778.1 - 1.4e-10 40.0 12.8 2e-10 39.5 8.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TFIIS_M PF07500.9 EFX00779.1 - 3.2e-27 94.8 0.3 1.1e-26 93.1 0.0 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 EFX00779.1 - 1.7e-18 65.9 8.1 2.7e-18 65.2 5.6 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 EFX00779.1 - 2.4e-14 52.5 0.2 4.9e-14 51.5 0.1 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Pol_alpha_B_N PF08418.5 EFX00779.1 - 2 7.9 10.6 1.1 8.7 0.5 2.4 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Cytochrome_C554 PF13435.1 EFX00779.1 - 9.6 6.2 11.0 0.74 9.8 3.7 2.0 2 0 0 2 2 2 0 Cytochrome c554 and c-prime AflR PF08493.5 EFX00780.1 - 9.7e-09 34.6 0.1 9.7e-09 34.6 0.1 2.1 2 1 0 2 2 2 1 Aflatoxin regulatory protein NPL4 PF05021.10 EFX00781.1 - 1.4e-125 418.4 0.0 1.9e-125 418.0 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 EFX00781.1 - 2.4e-69 231.6 0.1 3.6e-69 231.0 0.1 1.2 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 EFX00781.1 - 0.00089 19.4 0.0 0.004 17.4 0.0 2.1 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 RCC1 PF00415.13 EFX00782.1 - 4.4e-24 84.4 2.5 9.7e-06 25.6 0.0 7.5 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EFX00782.1 - 9.6e-09 34.6 25.9 3.4e-08 32.8 0.1 7.3 7 1 0 7 7 7 2 Regulator of chromosome condensation (RCC1) repeat Methyltransf_28 PF02636.12 EFX00783.1 - 2.8e-35 121.9 0.0 9.2e-35 120.2 0.0 1.8 2 1 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase YwiC PF14256.1 EFX00784.1 - 0.074 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 YwiC-like protein zf-C2H2_6 PF13912.1 EFX00785.1 - 5.7 6.9 5.1 4.5 7.3 1.6 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger WD40 PF00400.27 EFX00786.1 - 8.5e-11 41.3 15.8 0.0058 16.4 0.0 8.5 10 0 0 10 10 10 4 WD domain, G-beta repeat PD40 PF07676.7 EFX00786.1 - 0.0092 15.6 0.0 8.8 6.1 0.0 3.6 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat TFIIA PF03153.8 EFX00786.1 - 0.012 15.5 1.1 0.012 15.5 0.7 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cut8_N PF14482.1 EFX00786.1 - 0.072 13.1 1.8 0.78 9.7 0.1 2.8 2 0 0 2 2 2 0 Cut8 proteasome-binding domain Sigma70_ner PF04546.8 EFX00786.1 - 1.3 8.5 16.5 1.8 8.1 5.7 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region Nop14 PF04147.7 EFX00786.1 - 7.4 4.3 15.9 0.12 10.2 3.7 2.0 2 0 0 2 2 2 0 Nop14-like family zf-C2H2_2 PF12756.2 EFX00787.1 - 6.5e-27 93.6 1.0 1.1e-26 92.8 0.7 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 EFX00787.1 - 0.057 13.5 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EFX00787.1 - 7.7 7.0 6.6 19 5.8 0.1 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type Cation_efflux PF01545.16 EFX00789.1 - 2.4e-74 249.9 11.1 2.4e-73 246.7 7.7 2.0 1 1 0 1 1 1 1 Cation efflux family Ank_2 PF12796.2 EFX00789.1 - 1.6e-10 41.1 0.0 4.4e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFX00789.1 - 5.3e-08 32.2 0.1 0.096 12.5 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 EFX00789.1 - 2.1e-05 24.8 0.3 0.0024 18.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Zip PF02535.17 EFX00789.1 - 0.0048 15.9 16.6 0.25 10.3 0.1 2.3 2 0 0 2 2 2 2 ZIP Zinc transporter Ank_3 PF13606.1 EFX00789.1 - 0.04 14.1 0.0 18 5.9 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat DNA_methylase PF00145.12 EFX00790.1 - 2.4e-36 125.5 0.0 1.4e-27 96.6 0.0 2.1 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase BAH PF01426.13 EFX00790.1 - 1e-06 28.4 0.0 0.035 13.8 0.0 2.8 2 1 1 3 3 3 2 BAH domain SAC3_GANP PF03399.11 EFX00791.1 - 4.8e-24 85.0 0.0 1e-23 83.9 0.0 1.5 2 0 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EFX00791.1 - 7.6e-19 67.9 0.0 1.1e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Abhydrolase_1 PF00561.15 EFX00792.1 - 1.3e-12 47.8 0.0 1.5e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX00792.1 - 2.6e-10 40.5 8.2 1.4e-09 38.2 5.7 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX00792.1 - 7.8e-09 35.4 0.0 2.4e-07 30.6 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Rad4 PF03835.10 EFX00793.1 - 6e-15 54.9 2.9 1.1e-14 54.0 2.0 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 EFX00793.1 - 8.7e-14 51.6 3.0 2.4e-13 50.2 2.1 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily iPGM_N PF06415.8 EFX00794.1 - 4.6e-71 238.7 0.0 6.5e-71 238.2 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.13 EFX00794.1 - 1.2e-69 234.5 0.0 1.3e-69 234.3 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.17 EFX00794.1 - 1.4e-06 27.8 0.0 2.1e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFX00794.1 - 3.4e-06 26.4 0.0 1.5e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 Sulfatase AP_endonuc_2 PF01261.19 EFX00794.1 - 0.011 15.0 0.0 0.03 13.6 0.0 1.7 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel AAA PF00004.24 EFX00795.1 - 4.2e-38 130.5 0.0 1e-37 129.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EFX00795.1 - 9.2e-06 25.4 0.1 9.9e-05 22.1 0.0 2.7 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 EFX00795.1 - 1.2e-05 25.4 0.1 0.00026 21.1 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFX00795.1 - 9.5e-05 21.5 0.0 0.00023 20.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EFX00795.1 - 0.00055 19.8 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFX00795.1 - 0.0012 18.8 2.4 0.0039 17.2 0.2 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EFX00795.1 - 0.0013 18.4 0.0 0.0048 16.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 EFX00795.1 - 0.0017 17.7 0.0 0.0045 16.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 EFX00795.1 - 0.0035 16.1 0.0 0.0061 15.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.16 EFX00795.1 - 0.0039 16.3 0.2 0.0095 15.1 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EFX00795.1 - 0.012 15.3 0.5 0.056 13.2 0.1 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_33 PF13671.1 EFX00795.1 - 0.012 15.4 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 EFX00795.1 - 0.014 14.3 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.1 EFX00795.1 - 0.027 14.3 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EFX00795.1 - 0.03 13.7 0.2 0.12 11.7 0.1 2.0 1 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 EFX00795.1 - 0.032 15.0 0.0 0.077 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EFX00795.1 - 0.037 13.6 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFX00795.1 - 0.042 13.8 0.3 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 EFX00795.1 - 0.076 12.2 0.1 0.31 10.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.7 EFX00795.1 - 0.15 11.7 0.0 0.47 10.0 0.0 1.8 2 0 0 2 2 1 0 NACHT domain DUF972 PF06156.8 EFX00795.1 - 0.25 11.7 0.3 1.8 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF2360 PF10152.4 EFX00795.1 - 3.2 8.0 6.7 18 5.5 4.3 2.6 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF3123 PF11321.3 EFX00795.1 - 9.9 6.4 8.2 7.1 6.9 0.0 3.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3123) ASF1_hist_chap PF04729.8 EFX00796.1 - 5.2e-67 224.2 0.0 6.9e-67 223.8 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Suf PF05843.9 EFX00797.1 - 2.9e-70 237.2 0.0 2.8e-68 230.6 0.0 2.6 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) TPR_16 PF13432.1 EFX00797.1 - 6.5e-08 33.0 2.6 3.4e-07 30.7 0.5 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX00797.1 - 4.5e-05 23.7 2.6 0.0034 17.8 0.1 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00797.1 - 5.3e-05 23.4 0.0 0.054 13.8 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00797.1 - 0.34 10.9 2.1 1.5 8.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Cut8_N PF14482.1 EFX00798.1 - 0.039 13.9 0.9 0.098 12.6 0.7 1.7 1 0 0 1 1 1 0 Cut8 proteasome-binding domain ATP-synt_C PF00137.16 EFX00799.1 - 3.3e-16 58.9 11.1 6.4e-16 58.0 7.7 1.5 1 0 0 1 1 1 1 ATP synthase subunit C Gloverin PF10793.4 EFX00799.1 - 0.013 15.1 0.1 0.018 14.6 0.1 1.2 1 0 0 1 1 1 0 Gloverin-like protein RasGAP PF00616.14 EFX00800.1 - 9.2e-54 182.1 0.0 2.7e-53 180.5 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.10 EFX00800.1 - 7.6e-29 100.2 3.0 7.6e-29 100.2 2.0 2.0 2 0 0 2 2 2 1 RasGAP C-terminus DUF972 PF06156.8 EFX00800.1 - 0.23 11.8 8.8 2.1 8.7 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Syntaxin-6_N PF09177.6 EFX00800.1 - 0.38 11.2 3.4 0.9 9.9 0.5 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal PAP2 PF01569.16 EFX00801.1 - 5.1e-13 48.8 7.2 5.1e-13 48.8 5.0 2.6 1 1 2 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.1 EFX00801.1 - 1.6e-05 24.4 7.3 4.3e-05 23.1 5.1 1.7 1 1 0 1 1 1 1 PAP2 superfamily DUF155 PF02582.9 EFX00802.1 - 6.2e-31 107.6 0.0 7.3e-30 104.1 0.0 2.1 1 1 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CS PF04969.11 EFX00803.1 - 1e-12 48.4 0.0 1.8e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 CS domain SRP14 PF02290.10 EFX00804.1 - 1.4e-16 60.1 0.1 3.4e-16 58.9 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle 14kD protein LpxD PF04613.9 EFX00804.1 - 0.12 11.9 0.3 0.24 10.9 0.2 1.5 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD DUF4449 PF14613.1 EFX00804.1 - 0.12 12.3 2.2 0.16 11.8 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) EMG1 PF03587.9 EFX00806.1 - 3.2e-78 261.6 0.1 3.8e-78 261.4 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Vps51 PF08700.6 EFX00807.1 - 2e-26 91.6 0.1 4.6e-26 90.4 0.0 1.6 2 0 0 2 2 2 1 Vps51/Vps67 Dor1 PF04124.7 EFX00807.1 - 0.00011 20.8 0.1 0.00015 20.3 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.4 EFX00807.1 - 0.0025 17.7 0.0 0.0053 16.7 0.0 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Xpo1 PF08389.7 EFX00808.1 - 3.6e-09 36.7 3.9 0.00013 21.8 0.1 3.6 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.14 EFX00808.1 - 3.2e-05 23.7 0.0 0.00019 21.3 0.0 2.4 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 EFX00808.1 - 0.00024 21.3 0.1 0.0034 17.6 0.1 3.0 3 0 0 3 3 3 1 HEAT repeats Arm PF00514.18 EFX00808.1 - 0.035 13.9 1.9 0.25 11.2 0.6 3.0 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat HEAT PF02985.17 EFX00808.1 - 0.31 11.2 4.6 1.9 8.7 0.2 4.0 3 0 0 3 3 3 0 HEAT repeat tRNA-synt_2 PF00152.15 EFX00810.1 - 1.1e-95 320.2 0.0 1.4e-95 319.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 EFX00810.1 - 0.0023 17.1 0.1 0.017 14.3 0.1 2.3 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 EFX00810.1 - 0.013 15.0 0.1 0.058 12.9 0.2 1.8 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) Fungal_trans_2 PF11951.3 EFX00811.1 - 7.2e-10 38.0 0.2 1.1e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_11 PF08241.7 EFX00812.1 - 7.9e-11 42.3 0.0 1.7e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX00812.1 - 3.5e-08 33.3 0.0 5.3e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX00812.1 - 4.6e-05 23.8 0.0 0.00015 22.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX00812.1 - 0.00012 21.2 0.0 0.0002 20.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFX00812.1 - 0.001 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFX00812.1 - 0.021 14.4 0.0 0.13 11.8 0.0 2.0 1 1 1 2 2 2 0 Hypothetical methyltransferase Methyltransf_25 PF13649.1 EFX00812.1 - 0.071 13.4 0.0 0.27 11.6 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_PK PF05891.7 EFX00812.1 - 0.072 12.3 0.1 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase VanZ PF04892.7 EFX00814.1 - 5.5e-13 49.0 3.4 7.9e-13 48.5 2.4 1.2 1 0 0 1 1 1 1 VanZ like family DUF4401 PF14351.1 EFX00814.1 - 0.00097 18.2 0.5 0.0016 17.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4401) SWI-SNF_Ssr4 PF08549.5 EFX00814.1 - 0.029 12.6 0.6 0.035 12.4 0.4 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) FUSC PF04632.7 EFX00814.1 - 0.15 10.4 4.2 0.21 9.9 0.6 2.2 2 1 0 2 2 2 0 Fusaric acid resistance protein family DUF3487 PF11990.3 EFX00814.1 - 0.22 10.9 1.4 0.64 9.4 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) DASH_Spc34 PF08657.5 EFX00815.1 - 4.5e-50 170.7 0.0 1.5e-49 169.0 0.0 1.7 1 1 0 1 1 1 1 DASH complex subunit Spc34 IncA PF04156.9 EFX00815.1 - 4.5e-05 23.1 0.7 5.9e-05 22.7 0.5 1.2 1 0 0 1 1 1 1 IncA protein ATG16 PF08614.6 EFX00815.1 - 0.01 15.6 6.5 0.017 14.9 4.5 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) SlyX PF04102.7 EFX00815.1 - 0.016 15.5 5.0 1.2 9.5 0.2 2.4 2 0 0 2 2 2 0 SlyX TMF_DNA_bd PF12329.3 EFX00815.1 - 0.021 14.6 8.5 0.089 12.6 0.3 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.14 EFX00815.1 - 0.15 9.9 3.1 0.2 9.4 2.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OmpH PF03938.9 EFX00815.1 - 0.33 10.8 6.1 0.53 10.2 4.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.10 EFX00815.1 - 0.59 9.7 7.7 0.91 9.1 5.3 1.2 1 0 0 1 1 1 0 Mnd1 family Viral_P18 PF04521.8 EFX00815.1 - 0.95 8.9 5.9 9.7 5.6 0.2 2.2 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DivIC PF04977.10 EFX00815.1 - 1 8.8 6.2 11 5.5 1.3 2.3 2 0 0 2 2 2 0 Septum formation initiator Med9 PF07544.8 EFX00815.1 - 3 7.6 6.4 11 5.7 1.9 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TBCA PF02970.11 EFX00815.1 - 3.1 7.9 9.4 1.2 9.2 0.9 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A MOZ_SAS PF01853.13 EFX00816.1 - 4.4e-47 159.7 0.0 2.1e-46 157.5 0.0 2.0 1 1 0 1 1 1 1 MOZ/SAS family Nop14 PF04147.7 EFX00816.1 - 0.53 8.1 11.4 0.74 7.6 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family FAD_binding_2 PF00890.19 EFX00817.1 - 4.3e-83 279.4 1.4 5.5e-83 279.1 1.0 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.23 EFX00817.1 - 6.4e-21 73.9 0.2 3.4e-19 68.4 0.0 3.0 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.19 EFX00817.1 - 1.4e-13 50.5 1.6 5.8e-13 48.4 1.1 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 EFX00817.1 - 5.4e-10 38.9 0.5 2.3e-09 36.8 0.3 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX00817.1 - 1.4e-08 34.6 0.3 2.2e-07 30.7 0.1 2.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFX00817.1 - 2.5e-08 34.0 0.0 1.3e-06 28.4 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX00817.1 - 2e-06 26.5 2.5 0.0054 15.2 0.1 3.3 3 0 0 3 3 3 2 HI0933-like protein Thi4 PF01946.12 EFX00817.1 - 0.00016 20.8 0.6 0.018 14.1 0.2 2.6 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 EFX00817.1 - 0.0005 19.2 4.3 0.0064 15.5 3.0 2.1 1 1 0 1 1 1 1 FAD binding domain GIDA PF01134.17 EFX00817.1 - 0.0007 18.5 1.2 0.058 12.2 0.2 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A Amino_oxidase PF01593.19 EFX00817.1 - 0.0016 17.5 0.2 1.9 7.5 0.0 2.9 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 EFX00817.1 - 0.0026 18.1 0.7 0.051 13.9 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX00817.1 - 0.0056 16.7 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Period_C PF12114.3 EFX00817.1 - 0.072 12.6 6.5 0.12 11.9 4.5 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region 3HCDH_N PF02737.13 EFX00817.1 - 0.16 11.6 0.1 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SR-25 PF10500.4 EFX00817.1 - 5.1 6.5 10.3 8.1 5.8 7.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1708 PF08101.6 EFX00818.1 - 6.1e-152 506.2 0.0 7.7e-152 505.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) GNAT_acetyltr_2 PF13718.1 EFX00819.1 - 9.2e-79 263.3 0.0 1.5e-78 262.6 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 EFX00819.1 - 9.2e-64 214.3 0.0 2.7e-63 212.7 0.0 1.8 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 EFX00819.1 - 6.2e-39 131.5 0.0 1.6e-38 130.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 EFX00819.1 - 4.6e-32 110.1 0.4 1.4e-31 108.6 0.3 1.8 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 EFX00819.1 - 0.003 17.7 0.0 0.0088 16.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DNA_gyraseA_C PF03989.8 EFX00819.1 - 0.0073 15.5 0.0 0.036 13.3 0.0 2.2 2 0 0 2 2 2 1 DNA gyrase C-terminal domain, beta-propeller Pkinase PF00069.20 EFX00820.1 - 9.7e-66 221.5 0.0 2.4e-65 220.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00820.1 - 5.3e-47 160.0 0.4 1e-46 159.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00820.1 - 2.2e-07 30.1 0.0 2.2e-07 30.1 0.0 1.9 3 0 0 3 3 3 1 Kinase-like APH PF01636.18 EFX00820.1 - 0.074 12.7 6.1 0.24 11.0 0.0 3.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family GNT-I PF03071.10 EFX00820.1 - 2.5 6.5 4.8 4 5.8 1.8 1.9 2 0 0 2 2 2 0 GNT-I family AAA_23 PF13476.1 EFX00820.1 - 8.2 6.6 11.4 18 5.5 7.9 1.5 1 0 0 1 1 1 0 AAA domain 4HBT PF03061.17 EFX00821.1 - 1e-06 28.7 0.3 0.00017 21.6 0.1 2.4 2 0 0 2 2 2 2 Thioesterase superfamily THUMP PF02926.12 EFX00822.1 - 4.6e-13 49.2 0.1 8.2e-10 38.7 0.0 2.2 2 0 0 2 2 2 2 THUMP domain DUF3662 PF12401.3 EFX00822.1 - 0.077 13.1 0.0 0.5 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2662) ORC3_N PF07034.6 EFX00823.1 - 1.9e-31 109.3 0.1 1.2e-29 103.3 0.1 2.9 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus DUF2263 PF10021.4 EFX00824.1 - 6.2e-22 78.1 0.0 1.2e-21 77.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.16 EFX00824.1 - 0.033 14.1 0.0 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Macro domain Thioredoxin_4 PF13462.1 EFX00825.1 - 1.2e-05 25.3 0.0 3.1e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.15 EFX00825.1 - 0.026 14.0 1.0 0.14 11.6 0.1 2.4 2 1 1 3 3 3 0 DSBA-like thioredoxin domain DUF2013 PF09431.5 EFX00826.1 - 2.4e-49 166.7 4.0 2.4e-49 166.7 2.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) ketoacyl-synt PF00109.21 EFX00827.1 - 4.7e-84 281.8 0.0 7.9e-84 281.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX00827.1 - 1.2e-50 172.6 0.0 2.4e-50 171.6 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 EFX00827.1 - 3.5e-32 110.7 0.2 7.6e-32 109.6 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.15 EFX00827.1 - 1.4e-24 87.6 0.2 5.1e-24 85.7 0.0 2.0 2 0 0 2 2 2 1 Thioesterase domain PP-binding PF00550.20 EFX00827.1 - 3.3e-22 78.5 11.4 5e-11 42.7 0.4 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.1 EFX00827.1 - 1.4e-12 47.4 0.0 2.4e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.18 EFX00827.1 - 1.6e-06 27.3 0.2 5.3e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain Abhydrolase_5 PF12695.2 EFX00827.1 - 0.00015 21.5 0.1 0.14 11.9 0.0 2.8 2 0 0 2 2 2 2 Alpha/beta hydrolase family HTH_Mga PF08280.6 EFX00827.1 - 0.087 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Hairy_orange PF07527.8 EFX00827.1 - 0.19 11.4 0.0 0.83 9.4 0.0 2.1 2 0 0 2 2 2 0 Hairy Orange H_kinase_N PF12282.3 EFX00828.1 - 0.065 12.8 0.0 0.079 12.5 0.0 1.1 1 0 0 1 1 1 0 Signal transduction histidine kinase RRM_1 PF00076.17 EFX00829.1 - 4e-42 141.7 0.0 1.1e-18 66.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX00829.1 - 4.8e-35 119.3 0.0 1.2e-14 54.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX00829.1 - 6.9e-15 54.6 0.0 3.7e-06 26.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFX00829.1 - 0.00029 20.6 0.0 1 9.2 0.0 3.3 3 0 0 3 3 3 1 RNA binding motif Limkain-b1 PF11608.3 EFX00829.1 - 0.011 15.4 0.0 8.2 6.2 0.0 3.1 1 1 1 2 2 2 0 Limkain b1 ATP-grasp_2 PF08442.5 EFX00829.1 - 0.094 12.0 0.0 1.4 8.2 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain TBCC PF07986.7 EFX00830.1 - 1.1e-31 108.7 0.0 1.7e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Fungal_trans PF04082.13 EFX00831.1 - 7.8e-09 34.7 0.1 2.7e-05 23.1 0.0 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain MFS_1 PF07690.11 EFX00832.1 - 7.3e-37 126.8 58.7 7.3e-37 126.8 40.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX00832.1 - 7.2e-12 44.2 33.6 1.4e-11 43.3 23.0 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFX00832.1 - 9.3e-10 37.6 19.1 9.3e-10 37.6 13.3 2.6 3 1 0 3 3 3 1 Sugar (and other) transporter RTC PF01137.16 EFX00833.1 - 1.6e-28 99.0 0.0 3e-28 98.1 0.0 1.4 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 EFX00833.1 - 1.8e-25 88.9 0.4 4.3e-25 87.7 0.3 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Histone PF00125.19 EFX00834.1 - 8.7e-26 89.8 0.0 1.1e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFX00834.1 - 1.3e-05 25.1 0.0 1.7e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Cupin_8 PF13621.1 EFX00835.1 - 1.1e-13 51.3 0.0 2e-12 47.1 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 EFX00835.1 - 6.1e-10 39.3 0.0 1.3e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase F-box PF00646.28 EFX00835.1 - 7.3e-08 31.8 0.0 1.6e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFX00835.1 - 1.7e-07 30.8 0.0 4.3e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like DUF59 PF01883.14 EFX00836.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF59 Mei5 PF10376.4 EFX00838.1 - 0.013 15.0 0.3 0.029 13.8 0.0 1.7 2 0 0 2 2 2 0 Double-strand recombination repair protein Rad54_N PF08658.5 EFX00838.1 - 0.79 9.4 6.2 0.48 10.1 0.4 2.2 2 0 0 2 2 2 0 Rad54 N terminal NIF PF03031.13 EFX00840.1 - 9.1e-52 174.9 0.1 1.3e-51 174.4 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase TAP42 PF04177.7 EFX00840.1 - 0.02 13.8 0.0 0.04 12.8 0.0 1.5 1 1 0 1 1 1 0 TAP42-like family LRR_4 PF12799.2 EFX00842.1 - 4.7e-39 131.3 15.4 2.1e-12 46.3 1.1 7.2 4 2 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX00842.1 - 4.7e-24 83.9 36.1 1.4e-07 31.1 0.4 5.3 3 2 4 7 7 7 6 Leucine rich repeat LRR_1 PF00560.28 EFX00842.1 - 6e-12 43.8 21.5 0.22 11.6 0.1 9.9 10 1 0 10 10 10 5 Leucine Rich Repeat LRR_6 PF13516.1 EFX00842.1 - 2.7e-09 36.1 22.5 0.01 15.7 0.2 9.3 7 3 4 11 11 11 2 Leucine Rich repeat LRR_9 PF14580.1 EFX00842.1 - 3.8e-09 36.3 5.5 5.7e-06 26.0 0.7 3.3 1 1 1 3 3 3 2 Leucine-rich repeat LRR_7 PF13504.1 EFX00842.1 - 2e-07 30.0 22.6 0.11 12.7 0.1 9.0 9 1 1 10 10 10 3 Leucine rich repeat Sugar_tr PF00083.19 EFX00843.1 - 1.1e-114 383.5 30.8 1.2e-114 383.3 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX00843.1 - 4.7e-20 71.6 41.1 1e-12 47.4 9.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1418 PF07214.7 EFX00843.1 - 4.9 6.8 8.7 0.7 9.5 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DnaJ PF00226.26 EFX00844.1 - 2.3e-25 88.1 0.7 2.3e-25 88.1 0.5 2.8 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.3 EFX00844.1 - 2.3e-11 43.4 8.7 3.2e-10 39.8 1.8 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX00844.1 - 1.2e-09 38.0 8.1 9.5e-09 35.1 1.4 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EFX00844.1 - 2.4e-06 27.5 5.3 0.00016 21.7 0.6 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 EFX00844.1 - 5.4e-06 26.4 6.7 0.027 14.7 0.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX00844.1 - 7.7e-05 22.7 4.6 0.034 14.4 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met2 PF12907.2 EFX00844.1 - 0.007 16.3 2.2 0.007 16.3 1.5 2.3 2 0 0 2 2 2 1 Zinc-binding AKAP95 PF04988.7 EFX00844.1 - 0.012 15.3 1.2 0.25 11.1 0.0 2.4 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-BED PF02892.10 EFX00844.1 - 0.017 14.8 0.2 0.96 9.2 0.0 2.4 2 0 0 2 2 2 0 BED zinc finger RPT PF13446.1 EFX00844.1 - 0.028 13.8 0.1 0.13 11.6 0.0 2.1 2 0 0 2 2 2 0 A repeated domain in UCH-protein zf-C2H2_6 PF13912.1 EFX00844.1 - 2 8.4 5.3 0.71 9.8 0.5 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger Peptidase_C54 PF03416.14 EFX00845.1 - 4e-50 170.5 0.0 1.6e-31 109.5 0.0 2.1 1 1 1 2 2 2 2 Peptidase family C54 DEAD PF00270.24 EFX00846.1 - 2.3e-43 147.5 3.6 2.7e-43 147.4 1.8 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX00846.1 - 1e-27 95.8 0.3 6.2e-27 93.2 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX00846.1 - 0.00019 21.3 0.2 0.00045 20.0 0.1 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EFX00846.1 - 0.00075 19.1 0.2 0.002 17.7 0.1 1.7 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX00846.1 - 0.014 15.5 0.1 0.047 13.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EFX00846.1 - 0.02 14.6 0.1 0.055 13.2 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain UvrD-helicase PF00580.16 EFX00846.1 - 0.03 13.6 0.4 0.046 13.0 0.2 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain CMS1 PF14617.1 EFX00846.1 - 0.031 13.3 0.0 0.069 12.2 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.9 EFX00846.1 - 0.043 13.5 0.2 0.19 11.4 0.1 2.1 1 1 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.9 EFX00846.1 - 0.063 12.9 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Helicase tRNA-synt_1b PF00579.20 EFX00846.1 - 0.065 12.3 0.2 0.3 10.1 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) Fanconi_A PF03511.9 EFX00846.1 - 0.1 12.3 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Fanconi anaemia group A protein FNIP_M PF14637.1 EFX00847.1 - 0.065 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain DSBA PF01323.15 EFX00848.1 - 2.7e-34 118.4 0.0 3.1e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.1 EFX00848.1 - 0.00099 18.8 0.1 0.061 13.1 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_4 PF13462.1 EFX00848.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin APG9 PF04109.11 EFX00849.1 - 8.4e-163 541.5 5.8 1.1e-162 541.1 4.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Mid2 PF04478.7 EFX00850.1 - 0.0051 16.2 0.9 0.014 14.7 0.2 1.9 1 1 0 2 2 2 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 EFX00850.1 - 0.022 14.0 0.6 0.069 12.4 0.4 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain IncA PF04156.9 EFX00850.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 IncA protein TMEM154 PF15102.1 EFX00850.1 - 0.62 9.7 4.7 1.5 8.4 3.3 1.8 1 1 0 1 1 1 0 TMEM154 protein family Med3 PF11593.3 EFX00850.1 - 1.1 8.3 13.7 1.8 7.6 9.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Sporozoite_P67 PF05642.6 EFX00850.1 - 2 6.2 9.9 2.3 5.9 6.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MSP1_C PF07462.6 EFX00850.1 - 4.3 5.6 6.5 5.8 5.1 4.5 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Granulin PF00396.13 EFX00850.1 - 5.5 7.1 17.7 2.2 8.4 3.6 2.4 2 0 0 2 2 2 0 Granulin PALP PF00291.20 EFX00851.1 - 7e-53 179.8 2.0 9.3e-53 179.4 1.4 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Piwi PF02171.12 EFX00852.1 - 1.2e-83 280.6 0.0 2.5e-83 279.5 0.0 1.6 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.17 EFX00852.1 - 1.6e-13 50.1 0.2 3.2e-13 49.1 0.1 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 EFX00852.1 - 5.2e-13 48.1 0.0 1.6e-12 46.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Fungal_trans PF04082.13 EFX00853.1 - 4.5e-06 25.7 0.0 6.8e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Uso1_p115_head PF04869.9 EFX00853.1 - 0.16 10.6 0.0 0.25 10.0 0.0 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region F-box-like PF12937.2 EFX00855.1 - 2.1e-10 40.1 0.0 3.8e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX00855.1 - 0.025 14.2 0.0 0.053 13.1 0.0 1.6 1 0 0 1 1 1 0 F-box domain MFS_1 PF07690.11 EFX00856.1 - 4.5e-21 74.9 25.1 6.6e-21 74.3 17.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily BTB PF00651.26 EFX00858.1 - 3.6e-07 30.1 0.1 1.7e-06 27.9 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain DUF1656 PF07869.7 EFX00859.1 - 0.14 12.0 2.0 0.24 11.1 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) DUF1746 PF08508.5 EFX00861.1 - 1.8e-24 85.8 2.9 3.1e-21 75.4 0.0 2.2 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1746) Aldo_ket_red PF00248.16 EFX00862.1 - 1.6e-48 165.0 0.0 1.8e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4243 PF14027.1 EFX00863.1 - 4.8e-76 256.3 0.1 5.5e-76 256.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) DUF2452 PF10504.4 EFX00863.1 - 0.055 12.7 0.1 0.15 11.3 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2452) DUF2199 PF09965.4 EFX00863.1 - 0.099 12.4 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2199) AIG2 PF06094.7 EFX00864.1 - 2.7e-07 31.0 0.0 3.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family AIG2_2 PF13772.1 EFX00864.1 - 0.019 15.0 0.1 0.14 12.3 0.1 2.1 1 1 0 1 1 1 0 AIG2-like family Asp PF00026.18 EFX00865.1 - 1.3e-111 372.8 0.4 1.6e-111 372.6 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX00865.1 - 4.8e-13 49.3 0.1 2e-12 47.3 0.0 2.0 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EFX00865.1 - 2.1e-06 27.3 0.0 3.1e-05 23.5 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EFX00865.1 - 1.5e-05 25.4 0.1 0.4 11.2 0.0 3.2 2 2 1 3 3 3 2 Aspartyl protease Alpha-amylase_C PF02806.13 EFX00865.1 - 0.1 12.7 0.0 0.87 9.7 0.0 2.2 2 0 0 2 2 2 0 Alpha amylase, C-terminal all-beta domain BolA PF01722.13 EFX00866.1 - 2.1e-21 75.6 0.0 2.5e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein GTP_EFTU PF00009.22 EFX00867.1 - 2.7e-40 137.8 0.0 3.6e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EFX00867.1 - 1e-21 76.7 0.0 2.4e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 EFX00867.1 - 1.2e-16 60.3 0.0 3.4e-16 58.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFX00867.1 - 2.7e-08 33.8 0.0 6.6e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EFX00867.1 - 8e-06 25.6 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Miro PF08477.8 EFX00867.1 - 0.0042 17.5 0.0 0.024 15.1 0.0 2.3 2 1 0 2 2 2 1 Miro-like protein FAD_binding_3 PF01494.14 EFX00868.1 - 4.5e-16 58.8 0.0 1.3e-15 57.3 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain SE PF08491.5 EFX00868.1 - 7.2e-06 25.0 0.0 0.013 14.3 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase NAD_binding_8 PF13450.1 EFX00868.1 - 0.0037 17.2 0.1 0.014 15.4 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX00868.1 - 0.01 14.7 0.1 0.048 12.5 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFX00868.1 - 0.018 14.8 0.1 0.041 13.6 0.0 1.8 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFX00868.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SDH_alpha PF03313.10 EFX00869.1 - 1.4e-89 299.9 5.1 1.9e-89 299.4 3.5 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.10 EFX00869.1 - 5.1e-50 169.6 0.0 9.4e-50 168.7 0.0 1.4 1 0 0 1 1 1 1 Serine dehydratase beta chain TFIID_20kDa PF03847.8 EFX00870.1 - 2.5e-18 66.1 0.0 4.7e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A SnoaL_2 PF12680.2 EFX00872.1 - 0.00053 20.3 0.3 0.00071 19.9 0.2 1.2 1 0 0 1 1 1 1 SnoaL-like domain CRAL_TRIO PF00650.15 EFX00873.1 - 7.7e-37 126.2 0.0 8.3e-35 119.6 0.0 2.1 2 0 0 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFX00873.1 - 4.7e-10 39.4 0.6 1.3e-09 38.0 0.4 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EFX00873.1 - 0.00039 20.3 0.0 0.0014 18.5 0.0 1.9 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain RNA_polI_A34 PF08208.6 EFX00874.1 - 5.9e-27 94.6 2.9 5.9e-27 94.6 2.0 4.1 3 1 0 3 3 3 2 DNA-directed RNA polymerase I subunit RPA34.5 Bromodomain PF00439.20 EFX00876.1 - 1.1e-25 89.3 0.3 1.9e-25 88.5 0.2 1.4 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 EFX00876.1 - 6.2e-10 39.0 0.1 1.3e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX00876.1 - 9.7e-10 38.3 0.1 3e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFX00876.1 - 0.032 14.3 0.0 0.57 10.3 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Peptidase_M16 PF00675.15 EFX00877.1 - 1.7e-57 193.4 0.2 5.6e-57 191.6 0.3 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EFX00877.1 - 1.5e-38 132.3 0.1 1.3e-37 129.2 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain 2OG-FeII_Oxy PF03171.15 EFX00878.1 - 0.051 13.8 0.0 0.091 13.0 0.0 1.5 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Tim17 PF02466.14 EFX00879.1 - 1.2e-12 47.9 8.3 1.7e-12 47.5 5.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MAT1 PF06391.8 EFX00880.1 - 5.3e-30 104.4 0.7 7.3e-30 104.0 0.5 1.2 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_3 PF13920.1 EFX00880.1 - 0.002 17.7 5.6 0.0031 17.1 3.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MRP-S26 PF14943.1 EFX00880.1 - 0.016 14.7 9.0 0.03 13.8 6.2 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 zf-C3HC4 PF00097.20 EFX00880.1 - 0.019 14.6 4.8 0.046 13.3 3.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX00880.1 - 0.025 14.3 8.8 0.29 10.8 6.6 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.1 EFX00880.1 - 0.14 12.0 7.0 0.48 10.2 4.9 1.9 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 EFX00880.1 - 0.23 11.5 7.7 0.47 10.5 5.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UQ_con PF00179.21 EFX00881.1 - 5.7e-31 106.8 0.0 9.8e-19 67.1 0.0 2.5 2 1 0 2 2 2 2 Ubiquitin-conjugating enzyme RWD PF05773.17 EFX00881.1 - 0.052 13.4 0.0 0.54 10.1 0.0 2.3 1 1 0 2 2 2 0 RWD domain Acetyltransf_1 PF00583.19 EFX00882.1 - 0.0001 22.2 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFX00882.1 - 0.0012 18.6 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 EFX00882.1 - 0.0088 15.9 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MFS_1 PF07690.11 EFX00883.1 - 8.3e-28 97.1 39.0 8.3e-28 97.1 27.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX00883.1 - 6.4e-11 41.4 15.0 2.3e-10 39.6 10.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter ATG22 PF11700.3 EFX00883.1 - 0.00093 17.7 9.5 0.00093 17.7 6.6 2.1 2 1 0 2 2 2 1 Vacuole effluxer Atg22 like TRI12 PF06609.8 EFX00883.1 - 0.0013 17.0 0.6 0.0022 16.2 0.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4175 PF13779.1 EFX00883.1 - 0.43 8.2 0.6 0.61 7.7 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Clp1 PF06807.9 EFX00884.1 - 9.9e-08 31.9 0.0 3e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 EFX00884.1 - 3.2e-06 26.9 0.0 7.6e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 EFX00884.1 - 0.00023 21.9 0.0 0.00058 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFX00884.1 - 0.0018 18.1 0.2 0.008 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX00884.1 - 0.0022 18.1 0.0 0.0058 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EFX00884.1 - 0.0063 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_16 PF13191.1 EFX00884.1 - 0.0093 15.9 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain ArgK PF03308.11 EFX00884.1 - 0.0098 14.7 0.2 0.018 13.8 0.1 1.4 1 0 0 1 1 1 1 ArgK protein RNA_helicase PF00910.17 EFX00884.1 - 0.044 13.9 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 EFX00884.1 - 0.047 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFX00884.1 - 0.047 13.1 0.0 0.68 9.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.22 EFX00884.1 - 0.083 13.1 0.5 0.68 10.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter ATP_bind_1 PF03029.12 EFX00884.1 - 0.28 10.6 0.0 0.47 9.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein PRP3 PF08572.5 EFX00885.1 - 7.9e-64 215.0 4.0 1.1e-63 214.6 2.8 1.2 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 EFX00885.1 - 5.1e-33 113.4 0.0 1.4e-32 112.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) 2-oxoacid_dh PF00198.18 EFX00886.1 - 2.2e-62 210.3 0.1 3.1e-36 124.8 0.0 2.3 1 1 1 2 2 2 2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EFX00886.1 - 1.5e-19 69.3 6.9 2.8e-19 68.5 4.8 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_2 PF12700.2 EFX00886.1 - 0.00093 18.4 2.4 0.0068 15.5 0.2 2.1 1 1 1 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.1 EFX00886.1 - 0.0024 17.5 4.3 0.041 13.5 0.7 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.1 EFX00886.1 - 0.0066 16.1 1.3 0.016 14.9 0.9 1.7 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain GCV_H PF01597.14 EFX00886.1 - 0.034 13.8 1.0 0.067 12.8 0.7 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_3 PF13437.1 EFX00886.1 - 0.046 14.0 3.6 0.59 10.5 0.3 2.4 1 1 1 2 2 2 0 HlyD family secretion protein PRCC PF10253.4 EFX00886.1 - 0.13 12.9 6.1 0.079 13.6 2.7 1.6 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Mis14 PF08641.7 EFX00887.1 - 2.1e-05 24.5 0.5 4e-05 23.6 0.3 1.6 1 0 0 1 1 1 1 Kinetochore protein Mis14 like Tom22 PF04281.8 EFX00887.1 - 4.3 6.8 6.2 0.6 9.6 1.1 1.9 2 1 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 UPF0203 PF05254.7 EFX00888.1 - 4.2e-25 87.3 4.7 5.2e-25 87.0 3.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 EFX00888.1 - 0.00096 18.8 4.5 0.038 13.7 0.5 2.3 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.8 EFX00888.1 - 0.006 16.5 1.9 0.05 13.6 1.3 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Chordopox_A33R PF05966.7 EFX00888.1 - 0.033 12.9 1.1 0.035 12.8 0.7 1.1 1 0 0 1 1 1 0 Chordopoxvirus A33R protein UCR_hinge PF02320.11 EFX00888.1 - 0.25 11.3 4.5 0.81 9.6 2.6 2.0 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.8 EFX00888.1 - 2.3 8.2 5.5 0.34 10.8 0.4 2.2 2 0 0 2 2 2 0 CHCH domain Fig1 PF12351.3 EFX00889.1 - 2.1e-54 184.2 6.0 2.1e-54 184.2 4.2 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 EFX00889.1 - 1e-07 31.7 10.2 2e-07 30.8 7.1 1.5 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.8 EFX00889.1 - 2.6e-05 23.3 7.2 2.6e-05 23.3 5.0 1.9 1 1 0 2 2 2 1 Bacterial protein of unknown function (DUF898) SPASM PF13186.1 EFX00889.1 - 0.07 13.4 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Iron-sulfur cluster-binding domain DUF202 PF02656.10 EFX00889.1 - 0.19 11.9 11.6 0.24 11.6 0.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF202) DUF4131 PF13567.1 EFX00889.1 - 3.5 7.0 17.3 1.1 8.6 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DnaJ PF00226.26 EFX00890.1 - 5.4e-25 86.8 5.1 1.8e-23 82.0 1.9 2.8 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.1 EFX00890.1 - 3.3e-15 55.4 0.0 2.6e-07 30.1 0.0 5.7 3 3 3 6 6 6 5 TPR repeat TPR_14 PF13428.1 EFX00890.1 - 2.6e-14 52.4 11.6 0.0012 19.2 0.0 7.4 3 2 5 8 8 7 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00890.1 - 8.8e-14 50.2 10.7 0.0023 17.7 0.0 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX00890.1 - 9.6e-13 47.1 1.4 2.9e-05 23.4 0.0 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX00890.1 - 9.7e-13 48.4 5.8 3.9e-05 24.2 0.0 5.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFX00890.1 - 6e-09 35.0 1.0 0.0055 16.3 0.0 6.7 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX00890.1 - 1.7e-08 34.4 1.9 1 9.9 0.0 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFX00890.1 - 8e-08 32.0 1.3 0.0072 16.1 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00890.1 - 2.8e-07 30.7 6.1 0.022 15.0 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX00890.1 - 2.6e-06 27.1 0.3 0.031 14.4 0.1 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFX00890.1 - 0.00014 21.4 1.7 2.6 8.0 0.0 5.1 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFX00890.1 - 0.00023 21.0 5.9 0.15 12.0 0.0 5.5 3 2 4 7 7 6 2 Tetratricopeptide repeat Enkurin PF13864.1 EFX00890.1 - 0.027 14.6 2.1 7.3 6.8 0.4 2.9 2 1 0 2 2 2 0 Calmodulin-binding gag-asp_proteas PF13975.1 EFX00890.1 - 0.12 12.2 0.2 8.1 6.3 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Fasciclin PF02469.17 EFX00891.1 - 0.017 15.1 0.0 0.04 13.9 0.0 1.6 1 1 0 1 1 1 0 Fasciclin domain Sec34 PF04136.10 EFX00892.1 - 1.2e-26 93.2 0.2 3.1e-26 91.9 0.1 1.6 1 0 0 1 1 1 1 Sec34-like family Med11 PF10280.4 EFX00892.1 - 0.043 13.8 5.0 1.7 8.7 0.5 3.5 3 1 0 3 3 3 0 Mediator complex protein Bac_chlorC PF02043.12 EFX00892.1 - 0.11 12.3 0.0 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Bacteriochlorophyll C binding protein Det1 PF09737.4 EFX00892.1 - 0.25 10.0 1.8 0.69 8.6 0.3 2.1 2 0 0 2 2 2 0 De-etiolated protein 1 Det1 DUF3888 PF13027.1 EFX00893.1 - 0.096 12.5 0.2 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) Sel1 PF08238.7 EFX00894.1 - 2.9e-38 129.4 53.4 3.2e-05 24.3 0.1 12.8 14 1 1 15 15 15 10 Sel1 repeat TPR_11 PF13414.1 EFX00894.1 - 0.0063 16.1 0.4 0.0063 16.1 0.3 6.0 7 1 0 7 7 7 2 TPR repeat TLD PF07534.11 EFX00895.1 - 1.2e-27 96.5 0.0 6.2e-15 55.4 0.0 2.2 2 0 0 2 2 2 2 TLD XFP_N PF09364.5 EFX00896.1 - 6.9e-179 594.2 0.0 9e-179 593.9 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.10 EFX00896.1 - 4.1e-82 274.0 0.0 7.7e-82 273.1 0.0 1.5 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.5 EFX00896.1 - 5.2e-81 270.9 0.0 7.4e-81 270.4 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain DUF1917 PF08939.5 EFX00897.1 - 3.2e-47 161.3 0.0 8.9e-47 159.8 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1917) FA_desaturase PF00487.19 EFX00897.1 - 1.1e-38 133.1 24.0 1.7e-38 132.5 16.7 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 EFX00897.1 - 8.1e-12 44.7 0.0 1.6e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Coatomer_WDAD PF04053.9 EFX00899.1 - 6.7e-144 479.9 0.1 1.2e-143 479.1 0.0 1.4 2 0 0 2 2 2 1 Coatomer WD associated region COPI_C PF06957.6 EFX00899.1 - 5.8e-84 282.0 0.0 8.1e-84 281.6 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 EFX00899.1 - 4.2e-53 175.4 9.8 2.4e-09 36.7 0.0 8.1 9 0 0 9 9 9 6 WD domain, G-beta repeat Nup160 PF11715.3 EFX00899.1 - 0.0023 16.1 4.1 0.78 7.7 0.0 3.3 2 1 0 3 3 3 3 Nucleoporin Nup120/160 Clathrin PF00637.15 EFX00899.1 - 0.0091 15.6 1.8 0.23 11.0 0.0 3.0 3 0 0 3 3 3 1 Region in Clathrin and VPS TPP_enzyme_N PF02776.13 EFX00900.1 - 2.5e-34 118.2 0.0 4.4e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFX00900.1 - 7.3e-29 100.2 0.0 1.8e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 EFX00900.1 - 4e-16 58.9 0.5 7.6e-16 58.0 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain OCC1 PF15506.1 EFX00900.1 - 0.65 9.9 2.1 5.9 6.8 0.0 2.9 3 0 0 3 3 3 0 OCC1 family Thiolase_N PF00108.18 EFX00901.1 - 2.2e-95 318.6 0.1 2.2e-95 318.6 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFX00901.1 - 8.9e-47 157.5 2.7 1.3e-46 156.9 0.7 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFX00901.1 - 3.1e-05 23.6 0.3 6.9e-05 22.4 0.2 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EFX00901.1 - 0.016 14.8 0.7 0.97 9.1 0.0 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.11 EFX00902.1 - 5.5e-38 130.5 35.2 1.1e-36 126.3 25.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.20 EFX00903.1 - 3.4e-69 232.8 0.0 4.1e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00903.1 - 1.5e-29 102.9 0.0 1.9e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00903.1 - 1.3e-06 27.5 0.0 2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFX00903.1 - 0.00023 20.9 0.2 0.00042 20.1 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EFX00903.1 - 0.00088 18.3 0.0 0.0015 17.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EFX00903.1 - 0.039 13.3 0.0 0.092 12.0 0.0 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL AA_permease_2 PF13520.1 EFX00904.1 - 8e-28 97.1 23.6 8e-28 97.1 16.4 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.16 EFX00904.1 - 1.1e-07 30.6 34.5 9.2e-07 27.5 16.3 2.4 1 1 1 2 2 2 2 Amino acid permease PufQ PF05398.6 EFX00904.1 - 0.47 10.5 4.2 0.83 9.7 0.0 3.1 3 0 0 3 3 3 0 PufQ cytochrome subunit FAD_binding_3 PF01494.14 EFX00905.1 - 4.9e-07 29.1 0.0 7.4e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX00905.1 - 3.4e-05 22.9 0.0 0.00018 20.5 0.0 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase DUF1713 PF08213.6 EFX00906.1 - 4.7e-11 42.1 22.2 4.7e-11 42.1 15.4 2.1 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) FlxA PF14282.1 EFX00906.1 - 6.3e-05 22.8 6.1 6.3e-05 22.8 4.2 5.1 4 2 0 4 4 4 1 FlxA-like protein Pet20 PF08692.5 EFX00906.1 - 0.023 14.6 1.1 0.16 11.8 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial protein Pet20 SSP160 PF06933.6 EFX00907.1 - 5.5 4.8 10.3 7.1 4.4 7.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AAA PF00004.24 EFX00908.1 - 5.8e-15 55.6 0.0 2.8e-14 53.4 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EFX00908.1 - 4.4e-13 49.2 0.3 1.8e-06 27.7 0.0 3.1 3 0 0 3 3 3 2 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 EFX00908.1 - 1.1e-12 47.8 0.0 2.4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.10 EFX00908.1 - 1.5e-11 43.6 0.0 1.3e-08 33.9 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 EFX00908.1 - 2.8e-07 30.7 0.2 0.00034 20.7 0.0 3.6 2 2 0 2 2 2 1 AAA domain AAA_11 PF13086.1 EFX00908.1 - 3.4e-07 30.0 0.0 5.6e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFX00908.1 - 1.1e-06 27.8 0.0 2.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EFX00908.1 - 1.3e-05 25.2 1.0 0.0011 18.9 0.0 3.0 2 1 0 3 3 3 1 AAA ATPase domain AAA_19 PF13245.1 EFX00908.1 - 2.6e-05 23.8 0.0 6.3e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 EFX00908.1 - 0.00046 20.0 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EFX00908.1 - 0.00078 18.6 0.0 0.023 13.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 EFX00908.1 - 0.0017 19.1 0.2 0.0077 17.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 EFX00908.1 - 0.0017 17.9 0.6 0.0063 16.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EFX00908.1 - 0.0029 17.0 0.2 0.027 13.9 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family DUF815 PF05673.8 EFX00908.1 - 0.0057 15.6 1.1 0.0062 15.5 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 EFX00908.1 - 0.0062 15.9 0.1 0.026 13.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.4 EFX00908.1 - 0.0066 15.4 0.0 0.018 14.0 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) TMP_2 PF06791.8 EFX00908.1 - 0.0071 15.9 0.1 0.018 14.6 0.1 1.6 1 0 0 1 1 1 1 Prophage tail length tape measure protein Nro1 PF12753.2 EFX00908.1 - 0.0087 15.0 0.4 0.013 14.4 0.3 1.2 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 AAA_18 PF13238.1 EFX00908.1 - 0.01 16.1 0.1 0.054 13.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 EFX00908.1 - 0.01 15.6 0.4 0.32 10.7 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DNA_pol3_delta PF06144.8 EFX00908.1 - 0.014 14.9 0.2 0.032 13.7 0.0 1.7 2 0 0 2 2 1 0 DNA polymerase III, delta subunit AAA_28 PF13521.1 EFX00908.1 - 0.014 15.3 0.0 0.033 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFX00908.1 - 0.019 14.7 0.2 0.18 11.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 EFX00908.1 - 0.028 13.9 1.4 0.36 10.3 0.0 3.0 2 2 0 2 2 2 0 AAA domain AAA_33 PF13671.1 EFX00908.1 - 0.031 14.1 0.0 0.087 12.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain DEAD PF00270.24 EFX00908.1 - 0.051 13.0 0.0 0.89 9.0 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase TPM PF04536.9 EFX00908.1 - 0.054 13.3 0.5 0.21 11.4 0.1 2.2 3 0 0 3 3 2 0 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase AAA_10 PF12846.2 EFX00908.1 - 0.067 12.6 0.2 1.1 8.6 0.0 2.4 1 1 1 2 2 2 0 AAA-like domain AAA_3 PF07726.6 EFX00908.1 - 0.079 12.5 0.0 0.45 10.1 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 EFX00908.1 - 0.084 13.1 3.9 0.44 10.8 2.7 1.9 1 1 0 1 1 1 0 AAA domain CPL PF08144.6 EFX00908.1 - 0.096 12.5 1.7 0.26 11.0 0.7 1.9 1 1 1 2 2 2 0 CPL (NUC119) domain RNA_helicase PF00910.17 EFX00908.1 - 0.13 12.4 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase MutS_V PF00488.16 EFX00909.1 - 3.5e-97 324.4 0.0 5.1e-97 323.8 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFX00909.1 - 4.4e-37 127.8 1.8 1e-36 126.6 1.2 1.7 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.12 EFX00909.1 - 7e-22 77.9 0.1 7e-22 77.9 0.0 2.5 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.13 EFX00909.1 - 2e-17 63.1 2.0 7.9e-17 61.2 0.3 2.7 3 0 0 3 3 3 1 MutS family domain IV MutS_I PF01624.15 EFX00909.1 - 0.022 14.7 0.0 0.12 12.4 0.0 2.2 2 0 0 2 2 2 0 MutS domain I NIF3 PF01784.13 EFX00911.1 - 3.2e-55 187.3 0.0 4.1e-55 186.9 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Mur_ligase PF01225.20 EFX00912.1 - 0.097 12.7 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Mur ligase family, catalytic domain MFS_1 PF07690.11 EFX00914.1 - 3.5e-20 72.0 29.4 5e-19 68.2 16.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LETM1 PF07766.8 EFX00915.1 - 2.7e-11 43.0 0.0 5.7e-09 35.4 0.0 2.1 2 0 0 2 2 2 2 LETM1-like protein YbjN PF10722.4 EFX00915.1 - 0.048 13.7 0.1 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 Putative bacterial sensory transduction regulator Rad1 PF02144.11 EFX00916.1 - 1.6e-77 259.9 0.0 1.9e-77 259.7 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ferric_reduct PF01794.14 EFX00918.1 - 4.3e-15 55.9 16.6 4.3e-15 55.9 11.5 2.5 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EFX00918.1 - 1.4e-14 54.2 0.0 2.4e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFX00918.1 - 4.5e-08 32.9 0.0 1.3e-07 31.4 0.0 1.8 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 EFX00918.1 - 0.00011 22.6 0.0 0.092 13.3 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4611 PF15387.1 EFX00918.1 - 0.019 15.0 1.2 0.035 14.2 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.1 EFX00918.1 - 0.15 12.3 6.5 0.041 14.1 2.0 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YABBY PF04690.8 EFX00918.1 - 0.21 11.8 0.1 0.6 10.3 0.0 1.7 2 0 0 2 2 2 0 YABBY protein FRG1 PF06229.7 EFX00919.1 - 3.3e-57 193.0 0.4 3.3e-57 193.0 0.2 1.5 2 0 0 2 2 2 1 FRG1-like family Frataxin_Cyay PF01491.11 EFX00919.1 - 0.026 14.3 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 Frataxin-like domain Fascin PF06268.8 EFX00919.1 - 0.027 14.5 0.3 0.14 12.2 0.0 2.3 4 0 0 4 4 4 0 Fascin domain DUF4337 PF14235.1 EFX00919.1 - 0.15 11.9 2.7 2 8.2 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) SHMT PF00464.14 EFX00920.1 - 1.2e-210 698.8 0.0 1.4e-210 698.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 EFX00920.1 - 5.7e-05 22.0 0.0 9e-05 21.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFX00920.1 - 0.0019 17.3 0.0 0.0055 15.8 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase CPSase_L_D2 PF02786.12 EFX00921.1 - 1.2e-109 364.5 0.0 6.8e-84 280.3 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 EFX00921.1 - 9.3e-41 138.4 0.0 2e-40 137.3 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EFX00921.1 - 1.1e-37 129.6 1.1 3.3e-21 75.8 0.1 3.0 4 0 0 4 4 4 2 ATP-grasp domain CPSase_L_chain PF00289.17 EFX00921.1 - 6.7e-33 113.0 0.0 1.5e-15 57.2 0.0 2.9 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 EFX00921.1 - 7.1e-24 84.1 0.0 6.5e-08 31.6 0.0 3.8 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EFX00921.1 - 5.2e-21 74.7 0.0 4.5e-10 39.1 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFX00921.1 - 7.2e-17 61.4 0.1 1.1e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 EFX00921.1 - 4.1e-06 26.3 0.0 0.0016 17.9 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EFX00921.1 - 2.2e-05 24.3 0.0 0.094 12.5 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.14 EFX00921.1 - 5.1e-05 22.9 0.2 0.12 11.9 0.1 2.5 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.1 EFX00921.1 - 0.00019 20.6 0.3 0.29 10.3 0.1 2.6 2 1 0 2 2 2 2 ATP-grasp domain NAPRTase PF04095.11 EFX00922.1 - 1.6e-54 184.7 0.0 2.3e-54 184.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Evr1_Alr PF04777.8 EFX00923.1 - 7.2e-30 102.7 0.5 4.6e-29 100.1 0.1 2.0 2 0 0 2 2 2 1 Erv1 / Alr family Herpes_capsid PF06112.6 EFX00923.1 - 5.9 6.9 7.5 7.6 6.5 5.2 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein FAD_binding_4 PF01565.18 EFX00925.1 - 7.7e-19 67.5 0.6 6.9e-09 35.2 0.1 2.5 1 1 1 2 2 2 2 FAD binding domain ALO PF04030.9 EFX00925.1 - 3.6e-14 52.9 0.0 5.2e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase COQ9 PF08511.6 EFX00927.1 - 2.6e-27 94.1 0.0 4.2e-27 93.4 0.0 1.3 1 0 0 1 1 1 1 COQ9 ABC_membrane_2 PF06472.10 EFX00928.1 - 3.6e-94 315.0 4.3 1.6e-93 312.9 0.0 2.4 3 0 0 3 3 3 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EFX00928.1 - 3.1e-15 56.6 0.0 6.9e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.1 EFX00928.1 - 0.0052 17.1 1.5 0.19 12.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFX00928.1 - 0.018 14.5 0.1 0.039 13.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 EFX00928.1 - 0.021 14.7 0.0 0.066 13.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.14 EFX00928.1 - 0.12 11.6 0.1 2.5 7.2 0.1 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Histone PF00125.19 EFX00929.1 - 2.1e-22 79.0 0.3 3e-22 78.5 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFX00929.1 - 3.6e-05 23.7 0.0 9.6e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 EFX00929.1 - 0.00028 21.1 0.0 0.00046 20.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.8 EFX00929.1 - 0.0048 16.3 0.1 0.0068 15.8 0.1 1.2 1 0 0 1 1 1 1 Replication protein C N-terminal domain DUF1018 PF06252.7 EFX00929.1 - 0.027 14.9 0.5 0.037 14.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) 2OG-FeII_Oxy PF03171.15 EFX00930.1 - 4.1e-13 49.4 0.0 6.7e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EFX00930.1 - 1.8e-08 34.9 0.0 3.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal SGT1 PF07093.6 EFX00931.1 - 1.3e-47 162.5 12.6 1.5e-46 158.9 8.7 1.9 1 1 0 1 1 1 1 SGT1 protein IBR PF01485.16 EFX00932.1 - 2.6e-07 30.4 5.0 2.6e-07 30.4 3.5 4.1 3 1 0 3 3 3 2 IBR domain zf-RING_2 PF13639.1 EFX00932.1 - 0.0081 15.9 8.5 0.0081 15.9 5.9 3.7 2 1 0 2 2 2 1 Ring finger domain Bromodomain PF00439.20 EFX00934.1 - 5.4e-18 64.6 0.2 1.4e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.8 EFX00934.1 - 7.4e-10 38.4 0.2 2e-09 37.0 0.1 1.7 1 0 0 1 1 1 1 Bromodomain associated NAD_binding_10 PF13460.1 EFX00935.1 - 1.3e-12 48.0 0.0 1.8e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFX00935.1 - 0.00013 21.3 0.0 0.00025 20.3 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.19 EFX00935.1 - 0.012 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EFX00935.1 - 0.026 13.2 0.0 0.037 12.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EFX00935.1 - 0.18 10.7 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein tRNA-synt_2d PF01409.15 EFX00936.1 - 1.9e-85 286.0 0.0 2.7e-85 285.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 EFX00936.1 - 1.2e-06 27.5 0.1 0.00026 19.8 0.0 3.1 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 EFX00936.1 - 0.0036 16.9 0.0 0.006 16.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Plasmid_killer PF05015.8 EFX00936.1 - 0.11 12.6 0.1 0.27 11.4 0.1 1.6 1 0 0 1 1 1 0 Plasmid maintenance system killer protein DUF1044 PF06296.7 EFX00936.1 - 0.33 10.7 3.8 0.88 9.4 2.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1044) Drc1-Sld2 PF11719.3 EFX00937.1 - 2.4e-95 320.1 18.9 3e-95 319.8 13.1 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein TFIIF_alpha PF05793.7 EFX00937.1 - 5.4 5.2 30.4 0.051 11.9 2.5 2.8 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MBOAT PF03062.14 EFX00939.1 - 5.8e-43 147.2 23.6 5.8e-43 147.2 16.4 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Sec61_beta PF03911.11 EFX00940.1 - 8.9e-21 73.4 1.5 1.2e-20 73.0 1.0 1.2 1 0 0 1 1 1 1 Sec61beta family DUF1180 PF06679.7 EFX00940.1 - 4.3 7.1 7.4 6.7 6.5 5.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) DUF1767 PF08585.7 EFX00941.1 - 8e-09 35.6 0.2 1.4e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1767) Peripla_BP_3 PF13377.1 EFX00941.1 - 0.053 13.5 3.7 0.1 12.5 2.6 1.5 1 1 0 1 1 1 0 Periplasmic binding protein-like domain Sec66 PF09802.4 EFX00942.1 - 8.7e-72 240.5 0.0 1e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 PEP-utilisers_N PF05524.8 EFX00942.1 - 0.028 14.2 1.3 0.054 13.2 0.9 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal TPPII_N PF12583.3 EFX00942.1 - 6.4 6.9 7.4 13 5.9 5.2 1.5 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal PAH PF02671.16 EFX00943.1 - 9.8e-47 156.3 0.7 1.1e-19 69.7 0.3 3.5 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 EFX00943.1 - 2.1e-37 126.8 0.0 6.3e-37 125.3 0.0 1.9 1 0 0 1 1 1 1 Sin3 family co-repressor TPR_11 PF13414.1 EFX00944.1 - 1.4e-32 111.1 32.0 0.00012 21.6 0.1 11.9 9 3 4 13 13 13 9 TPR repeat TPR_16 PF13432.1 EFX00944.1 - 6.5e-20 71.2 61.0 4.8e-08 33.4 1.3 13.2 9 3 6 15 15 15 7 Tetratricopeptide repeat TPR_14 PF13428.1 EFX00944.1 - 1.1e-18 65.9 39.9 0.017 15.6 0.0 14.0 10 4 4 14 14 13 4 Tetratricopeptide repeat TPR_19 PF14559.1 EFX00944.1 - 1.2e-15 57.5 29.4 0.00011 22.4 1.2 12.5 11 2 2 13 13 13 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFX00944.1 - 1.2e-13 49.7 39.4 0.16 11.9 0.1 14.0 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_1 PF00515.23 EFX00944.1 - 5.9e-13 47.8 26.1 0.13 11.9 0.1 11.6 12 1 0 12 12 12 4 Tetratricopeptide repeat TPR_12 PF13424.1 EFX00944.1 - 1.7e-11 43.9 47.0 0.023 14.6 0.6 12.4 7 4 9 16 16 16 6 Tetratricopeptide repeat TPR_7 PF13176.1 EFX00944.1 - 2.4e-10 39.3 14.8 0.0039 16.8 0.0 10.2 10 1 1 11 11 10 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX00944.1 - 4.6e-10 38.5 12.1 0.54 10.1 0.1 9.9 11 1 1 12 12 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX00944.1 - 6.1e-07 29.1 10.9 4.6 7.6 0.0 11.7 14 0 0 14 14 11 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFX00944.1 - 0.00085 19.1 20.3 0.031 14.2 0.2 7.9 8 0 0 8 8 7 1 Tetratricopeptide repeat DUF3856 PF12968.2 EFX00944.1 - 0.0023 17.7 8.5 2.6 7.8 0.3 5.1 4 2 0 4 4 4 2 Domain of Unknown Function (DUF3856) ChAPs PF09295.5 EFX00944.1 - 0.041 12.6 0.1 2.5 6.7 0.0 3.2 4 0 0 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.1 EFX00944.1 - 0.056 13.9 27.1 5.1 7.7 0.1 10.7 13 0 0 13 13 11 0 Tetratricopeptide repeat Nucleoplasmin PF03066.10 EFX00944.1 - 0.073 12.5 2.1 0.15 11.5 1.5 1.5 1 0 0 1 1 1 0 Nucleoplasmin RdRP_5 PF07925.6 EFX00944.1 - 0.22 8.8 0.0 0.32 8.3 0.0 1.1 1 0 0 1 1 1 0 Reovirus RNA-dependent RNA polymerase lambda 3 Fis1_TPR_C PF14853.1 EFX00944.1 - 0.3 10.9 12.2 6.2 6.7 0.1 5.9 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat MIF4G PF02854.14 EFX00945.1 - 1.2e-16 60.8 0.0 4.9e-16 58.7 0.0 2.0 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.12 EFX00945.1 - 2.9e-11 43.0 0.0 1.8e-10 40.4 0.0 2.4 1 1 0 1 1 1 1 MA3 domain adh_short_C2 PF13561.1 EFX00946.1 - 7.1e-29 101.2 0.1 8.8e-29 100.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX00946.1 - 5e-28 98.1 0.2 6.8e-28 97.6 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX00946.1 - 3e-11 43.3 0.2 4.3e-11 42.7 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX00946.1 - 0.049 13.0 0.2 0.14 11.5 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_11 PF08241.7 EFX00946.1 - 0.081 13.4 0.1 0.81 10.2 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 EFX00946.1 - 0.14 11.6 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain FRQ PF09421.5 EFX00947.1 - 5.1e-240 799.1 55.3 3.1e-239 796.5 38.4 1.9 1 1 0 1 1 1 1 Frequency clock protein tRNA-synt_2c PF01411.14 EFX00948.1 - 7.4e-209 694.6 0.0 1e-208 694.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 EFX00948.1 - 6.5e-17 61.1 0.6 2e-16 59.6 0.4 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 EFX00948.1 - 0.0014 18.3 0.2 0.004 16.8 0.1 1.9 1 0 0 1 1 1 1 DHHA1 domain RINT1_TIP1 PF04437.8 EFX00949.1 - 2.3e-77 260.6 0.0 3.1e-77 260.2 0.0 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family DNA_pol_A_exo1 PF01612.15 EFX00949.1 - 3.2e-40 137.4 0.2 6.7e-40 136.4 0.1 1.6 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.7 EFX00949.1 - 3.8e-23 81.5 0.6 9.7e-23 80.2 0.4 1.8 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.18 EFX00949.1 - 5.9e-09 35.5 0.1 1.7e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 HRDC domain CRISPR_Cse2 PF09485.5 EFX00949.1 - 0.0066 16.5 15.0 0.0092 16.0 4.2 3.7 3 0 0 3 3 3 1 CRISPR-associated protein Cse2 (CRISPR_cse2) BTB PF00651.26 EFX00950.1 - 0.0024 17.8 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain SMC_N PF02463.14 EFX00951.1 - 2.6e-20 72.5 9.7 1.4e-19 70.2 6.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFX00951.1 - 1.8e-11 44.7 20.0 1.8e-11 44.7 13.9 5.2 3 2 0 3 3 3 1 AAA domain AAA_21 PF13304.1 EFX00951.1 - 2.2e-06 27.8 0.1 7.6e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EFX00951.1 - 6.4e-06 25.4 1.1 1.4e-05 24.3 0.7 1.6 1 0 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.1 EFX00951.1 - 8.8e-05 22.3 0.1 0.00035 20.4 0.0 2.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 EFX00951.1 - 0.00089 18.7 0.0 0.0021 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Toxin_trans PF07952.7 EFX00951.1 - 0.019 13.8 5.1 0.02 13.7 0.1 2.7 2 0 0 2 2 2 0 Clostridium neurotoxin, Translocation domain ABC_tran PF00005.22 EFX00951.1 - 0.09 13.0 0.2 0.09 13.0 0.1 5.9 5 1 0 5 5 5 0 ABC transporter Reo_sigmaC PF04582.7 EFX00951.1 - 0.1 11.7 4.2 0.43 9.7 0.2 3.2 3 0 0 3 3 3 0 Reovirus sigma C capsid protein tRNA_m1G_MT PF01746.16 EFX00953.1 - 1.1e-34 119.6 0.1 5.7e-32 110.8 0.1 2.2 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase RRXRR PF14239.1 EFX00953.1 - 0.0012 18.3 0.6 0.0019 17.6 0.4 1.3 1 0 0 1 1 1 1 RRXRR protein Nucleoplasmin PF03066.10 EFX00953.1 - 1.2 8.5 9.9 0.98 8.9 2.5 2.5 2 0 0 2 2 2 0 Nucleoplasmin NARP1 PF12569.3 EFX00953.1 - 4.6 5.8 8.4 8.6 4.9 5.8 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4187 PF13821.1 EFX00954.1 - 1.1e-13 50.5 0.7 1.1e-13 50.5 0.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.18 EFX00954.1 - 3.9e-10 39.3 2.1 4e-09 36.1 1.5 2.3 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EFX00954.1 - 6.4e-05 22.7 0.3 0.00025 20.8 0.2 2.0 1 0 0 1 1 1 1 DExH-box splicing factor binding site AAA PF00004.24 EFX00955.1 - 1.8e-45 154.3 0.1 5.1e-45 152.9 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX00955.1 - 8e-09 35.3 0.4 2.9e-08 33.5 0.1 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFX00955.1 - 4.8e-08 33.1 0.0 1e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFX00955.1 - 6.4e-07 29.5 0.0 1.9e-06 28.0 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX00955.1 - 8.7e-07 29.1 0.6 0.001 19.1 0.0 2.7 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.8 EFX00955.1 - 3.6e-06 26.0 0.0 7.6e-06 25.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.1 EFX00955.1 - 0.00021 21.1 0.2 0.00085 19.2 0.0 2.1 3 0 0 3 3 2 1 AAA domain RuvB_N PF05496.7 EFX00955.1 - 0.00035 19.6 0.0 0.00082 18.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 EFX00955.1 - 0.00037 20.4 0.0 0.00082 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX00955.1 - 0.00058 20.6 0.0 0.0022 18.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.7 EFX00955.1 - 0.0012 17.9 0.1 0.0039 16.3 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 EFX00955.1 - 0.0014 18.3 0.2 0.0035 17.0 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 EFX00955.1 - 0.0014 17.4 0.0 0.0026 16.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus NACHT PF05729.7 EFX00955.1 - 0.0014 18.3 0.3 0.058 13.0 0.0 2.5 1 1 0 2 2 2 1 NACHT domain RNA_helicase PF00910.17 EFX00955.1 - 0.0019 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_30 PF13604.1 EFX00955.1 - 0.0024 17.4 0.0 0.0048 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EFX00955.1 - 0.0029 17.3 0.0 0.009 15.7 0.0 1.9 1 0 0 1 1 1 1 NTPase AAA_3 PF07726.6 EFX00955.1 - 0.0037 16.8 0.0 0.011 15.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFX00955.1 - 0.0055 16.1 0.7 0.061 12.7 0.4 2.4 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.1 EFX00955.1 - 0.0056 16.2 0.1 0.017 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFX00955.1 - 0.0056 16.5 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EFX00955.1 - 0.006 15.7 0.2 0.014 14.6 0.1 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_23 PF13476.1 EFX00955.1 - 0.007 16.7 0.2 1.2 9.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX00955.1 - 0.009 16.3 0.0 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EFX00955.1 - 0.0092 15.7 0.5 0.058 13.0 0.0 2.4 2 1 0 2 2 2 1 Archaeal ATPase IstB_IS21 PF01695.12 EFX00955.1 - 0.0098 15.3 0.2 0.024 14.0 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 EFX00955.1 - 0.012 15.2 0.7 0.03 13.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 EFX00955.1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein KaiC PF06745.8 EFX00955.1 - 0.019 14.1 1.1 0.42 9.6 0.0 2.7 3 0 0 3 3 3 0 KaiC UPF0079 PF02367.12 EFX00955.1 - 0.02 14.5 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activ_2 PF14532.1 EFX00955.1 - 0.021 14.9 0.0 0.37 10.8 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain Cast PF10174.4 EFX00955.1 - 0.025 12.6 2.1 0.045 11.8 0.8 1.7 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone Sigma54_activat PF00158.21 EFX00955.1 - 0.037 13.4 0.0 1.2 8.5 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_Hsp90 PF03225.9 EFX00955.1 - 0.077 11.2 0.0 0.13 10.5 0.0 1.3 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue NB-ARC PF00931.17 EFX00955.1 - 0.11 11.3 0.0 0.2 10.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.12 EFX00955.1 - 0.17 10.7 0.0 0.31 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Pyr_redox_2 PF07992.9 EFX00956.1 - 5.4e-42 143.9 0.0 2.4e-41 141.8 0.0 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 EFX00956.1 - 1.8e-41 140.5 0.0 4.6e-41 139.2 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 EFX00956.1 - 2.4e-23 82.3 8.9 2e-20 72.9 0.2 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX00956.1 - 2.9e-10 40.0 3.8 1.4e-05 25.0 0.6 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EFX00956.1 - 3.3e-09 36.3 0.7 3.3e-09 36.3 0.5 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.17 EFX00956.1 - 9.5e-09 34.5 8.2 6.9e-07 28.4 3.0 2.5 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.19 EFX00956.1 - 2.1e-08 33.4 10.4 2.3e-07 30.0 2.9 3.2 4 0 0 4 4 4 1 FAD binding domain Thi4 PF01946.12 EFX00956.1 - 4.7e-07 29.1 4.0 2e-05 23.7 0.4 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.19 EFX00956.1 - 1.3e-06 27.6 15.8 0.00058 18.8 2.4 3.5 2 2 1 4 4 4 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX00956.1 - 3.1e-06 27.4 2.4 0.0005 20.2 1.3 2.9 1 1 2 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX00956.1 - 3.4e-05 22.5 13.1 0.00019 20.0 2.0 3.9 4 0 0 4 4 4 1 HI0933-like protein AlaDh_PNT_C PF01262.16 EFX00956.1 - 0.00011 21.8 1.9 0.11 12.1 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.1 EFX00956.1 - 0.00055 18.9 0.1 0.032 13.1 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 EFX00956.1 - 0.0012 17.9 6.1 0.26 10.2 0.2 2.5 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EFX00956.1 - 0.02 13.8 4.3 0.027 13.4 0.2 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_7 PF13241.1 EFX00956.1 - 0.033 14.4 1.4 8.5 6.6 0.0 3.1 3 0 0 3 3 3 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 EFX00956.1 - 0.33 10.5 4.9 0.54 9.8 0.1 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.9 EFX00956.1 - 2.7 6.5 6.5 0.46 9.0 1.1 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Zn_clus PF00172.13 EFX00957.1 - 3.7e-07 29.9 10.3 6.2e-07 29.2 7.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hid1 PF12722.2 EFX00957.1 - 0.13 9.8 14.8 0.18 9.4 2.2 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein AAA_23 PF13476.1 EFX00957.1 - 0.15 12.3 14.4 0.18 12.1 4.0 2.4 2 0 0 2 2 2 0 AAA domain Med15 PF09606.5 EFX00957.1 - 0.2 9.7 81.7 0.7 8.0 14.2 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SAPS PF04499.10 EFX00957.1 - 0.23 10.0 10.2 1.1 7.7 0.7 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein FimP PF09766.4 EFX00957.1 - 0.6 9.1 40.3 1.4 7.8 13.5 2.4 2 0 0 2 2 2 0 Fms-interacting protein DUF2052 PF09747.4 EFX00957.1 - 0.61 9.9 22.6 2.4 8.0 4.7 2.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Gti1_Pac2 PF09729.4 EFX00957.1 - 0.61 9.9 9.6 4.5 7.1 0.3 2.5 2 0 0 2 2 2 0 Gti1/Pac2 family PIG-P PF08510.7 EFX00957.1 - 2 8.0 4.6 51 3.5 0.2 3.4 3 0 0 3 3 3 0 PIG-P Spt20 PF12090.3 EFX00957.1 - 2.8 7.2 30.3 0.11 11.8 0.6 3.0 3 0 0 3 3 3 0 Spt20 family NARP1 PF12569.3 EFX00957.1 - 3.1 6.4 19.4 0.25 10.0 1.2 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 IncA PF04156.9 EFX00957.1 - 4.1 6.9 29.1 0.18 11.3 7.4 3.1 3 0 0 3 3 3 0 IncA protein Ycf1 PF05758.7 EFX00957.1 - 5 4.7 14.3 3.4 5.2 0.3 2.1 2 0 0 2 2 2 0 Ycf1 FAM60A PF15396.1 EFX00957.1 - 5.9 6.5 15.5 4 7.1 1.8 2.7 2 0 0 2 2 2 0 Protein Family FAM60A DHHW PF14286.1 EFX00957.1 - 6.1 6.0 13.2 6.6 5.9 2.2 2.3 2 0 0 2 2 2 0 DHHW protein POX PF07526.6 EFX00957.1 - 6.5 6.9 25.3 1.9 8.6 4.6 2.8 3 0 0 3 3 2 0 Associated with HOX Pal1 PF08316.6 EFX00957.1 - 8.1 6.8 16.0 5.3 7.5 1.4 3.4 3 0 0 3 3 3 0 Pal1 cell morphology protein EIIBC-GUT_N PF03612.9 EFX00957.1 - 8.5 5.9 14.6 2.2 7.8 3.2 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Mannosyl_trans3 PF11051.3 EFX00958.1 - 4.9e-45 153.9 0.0 8.3e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.15 EFX00958.1 - 0.098 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 8 DUF4448 PF14610.1 EFX00959.1 - 3.8e-42 143.9 0.0 1.1e-41 142.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) Pkinase PF00069.20 EFX00960.1 - 1.4e-74 250.4 0.0 2e-74 250.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00960.1 - 9.1e-32 110.1 0.0 1.2e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX00960.1 - 0.00056 18.9 0.0 0.0011 17.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX00960.1 - 0.0023 17.0 0.1 0.0041 16.2 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX00960.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFX00960.1 - 0.061 12.1 0.0 0.093 11.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.6 EFX00960.1 - 0.081 12.9 0.1 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Gag protein p6 S_100 PF01023.14 EFX00960.1 - 0.1 11.9 0.3 0.36 10.2 0.2 1.9 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Gpi1 PF05024.10 EFX00961.1 - 2.1e-64 216.7 6.8 2.1e-64 216.7 4.7 1.7 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) 7tm_1 PF00001.16 EFX00961.1 - 0.00014 21.0 0.7 0.00014 21.0 0.5 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF3333 PF11812.3 EFX00961.1 - 0.069 13.1 0.2 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) Cys_Met_Meta_PP PF01053.15 EFX00962.1 - 9.5e-27 93.2 0.0 3e-26 91.6 0.0 1.8 2 1 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EFX00962.1 - 0.29 10.0 0.0 0.51 9.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Folliculin PF11704.3 EFX00963.1 - 8.9e-27 93.7 0.0 3.9e-25 88.3 0.0 2.9 1 1 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport SLD3 PF08639.5 EFX00964.1 - 2.2 6.8 5.8 3.9 6.0 4.0 1.3 1 0 0 1 1 1 0 DNA replication regulator SLD3 Metallophos PF00149.23 EFX00965.1 - 3.4e-13 49.4 0.1 1.7e-09 37.3 0.0 2.5 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase Mito_carr PF00153.22 EFX00966.1 - 1.1e-58 194.9 2.4 1.1e-21 76.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein AAA_22 PF13401.1 EFX00967.1 - 0.14 12.2 0.0 0.74 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Ribosomal_L18ae PF01775.12 EFX00968.1 - 9.6e-59 196.7 0.4 1.2e-58 196.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain Sec63 PF02889.11 EFX00969.1 - 2.7e-164 545.9 0.0 1.1e-99 333.6 0.0 2.6 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EFX00969.1 - 9.7e-52 174.8 0.0 1.6e-29 102.5 0.0 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 EFX00969.1 - 2.9e-14 53.3 0.3 9.7e-08 32.0 0.0 3.3 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit PWWP PF00855.12 EFX00969.1 - 3.6e-13 49.5 0.0 1.6e-12 47.4 0.0 2.2 1 0 0 1 1 1 1 PWWP domain Helicase_C PF00271.26 EFX00969.1 - 3.5e-10 39.6 0.0 6.4e-09 35.5 0.0 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFX00969.1 - 0.00034 20.7 0.3 0.017 15.3 0.1 3.4 2 1 0 2 2 2 1 AAA domain DUF3335 PF11814.3 EFX00969.1 - 0.055 12.5 0.0 0.22 10.6 0.0 1.9 2 0 0 2 2 2 0 Peptidase_C39 like family Epimerase PF01370.16 EFX00970.1 - 8.5e-11 41.7 0.1 0.00035 20.0 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 EFX00970.1 - 5.1e-05 23.5 0.3 0.00048 20.4 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 EFX00970.1 - 0.00086 18.3 0.0 0.0015 17.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 EFX00970.1 - 0.0059 15.3 0.0 0.34 9.5 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFX00970.1 - 0.099 11.5 0.1 0.39 9.5 0.0 2.0 2 1 0 2 2 2 0 Male sterility protein Polysacc_synt_2 PF02719.10 EFX00970.1 - 0.13 11.0 0.0 0.23 10.2 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Y_phosphatase PF00102.22 EFX00972.1 - 8.2e-47 159.5 0.0 2.3e-20 72.9 0.0 3.2 3 0 0 3 3 3 3 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EFX00972.1 - 0.0007 19.6 0.0 0.0021 18.1 0.0 1.8 2 0 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.15 EFX00972.1 - 0.012 15.2 0.0 0.034 13.7 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain ANTH PF07651.11 EFX00975.1 - 1.2e-64 217.7 0.1 1.5e-64 217.4 0.1 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 EFX00975.1 - 4.1e-05 23.4 0.0 9.5e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 ENTH domain Med9 PF07544.8 EFX00976.1 - 2.6e-12 46.2 1.0 3.7e-12 45.8 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 ACT_4 PF13291.1 EFX00976.1 - 0.028 14.7 0.0 0.036 14.3 0.0 1.1 1 0 0 1 1 1 0 ACT domain Med21 PF11221.3 EFX00976.1 - 0.049 13.6 0.2 0.055 13.4 0.2 1.2 1 0 0 1 1 1 0 Subunit 21 of Mediator complex DivIC PF04977.10 EFX00976.1 - 0.064 12.7 0.3 0.083 12.3 0.2 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.1 EFX00976.1 - 0.079 13.4 0.9 0.11 12.9 0.6 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CCDC-167 PF15188.1 EFX00976.1 - 0.11 12.4 0.2 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 SlyX PF04102.7 EFX00976.1 - 0.17 12.2 1.1 0.23 11.8 0.8 1.3 1 0 0 1 1 1 0 SlyX OmpH PF03938.9 EFX00976.1 - 0.26 11.2 3.4 0.29 11.0 2.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1344 PF07076.6 EFX00977.1 - 0.091 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) Cellulase PF00150.13 EFX00978.1 - 1.8e-12 47.0 0.7 5.6e-08 32.3 0.6 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.14 EFX00978.1 - 0.0038 16.6 0.1 0.0064 15.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 zf-RING_2 PF13639.1 EFX00979.1 - 3.9e-07 29.8 11.0 7.5e-07 28.8 7.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFX00979.1 - 1.3e-06 28.3 9.4 2.3e-06 27.5 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX00979.1 - 1.5e-06 27.7 7.2 2.5e-06 27.0 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX00979.1 - 4.3e-05 23.0 5.8 7.3e-05 22.3 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFX00979.1 - 0.0092 16.0 8.1 0.029 14.4 5.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Nse PF11789.3 EFX00979.1 - 0.94 9.0 3.7 1.7 8.2 2.6 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Mannosyl_trans3 PF11051.3 EFX00980.1 - 1.2e-47 162.5 0.0 1.8e-47 161.9 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Ribosomal_S17 PF00366.15 EFX00981.1 - 4.9e-06 26.4 0.5 8.4e-06 25.7 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Menin PF05053.8 EFX00981.1 - 0.074 11.2 6.3 0.1 10.7 4.4 1.3 1 0 0 1 1 1 0 Menin RskA PF10099.4 EFX00982.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA PCI PF01399.22 EFX00984.1 - 2.9e-12 46.8 0.0 7.1e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 PCI domain TPR_11 PF13414.1 EFX00984.1 - 0.036 13.6 0.1 0.094 12.3 0.1 1.7 1 0 0 1 1 1 0 TPR repeat TPR_2 PF07719.12 EFX00984.1 - 0.087 12.7 1.8 0.15 12.0 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_47 PF01532.15 EFX00985.1 - 3.9e-168 559.7 0.0 4.7e-168 559.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 ERbeta_N PF12497.3 EFX00986.1 - 0.075 12.8 10.4 0.032 14.0 4.5 2.1 1 1 1 2 2 2 0 Estrogen receptor beta Nrap PF03813.9 EFX00987.1 - 3.1e-293 975.0 0.0 3.7e-293 974.7 0.0 1.0 1 0 0 1 1 1 1 Nrap protein Rpn3_C PF08375.6 EFX00988.1 - 1.1e-24 86.5 1.4 2.8e-24 85.3 1.0 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 EFX00988.1 - 3.2e-20 72.3 0.2 1.2e-19 70.5 0.0 2.0 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.12 EFX00988.1 - 0.0031 17.2 0.1 0.015 15.1 0.1 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat Metallophos PF00149.23 EFX00989.1 - 8.4e-12 44.9 0.3 1.9e-11 43.7 0.2 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase E1-E2_ATPase PF00122.15 EFX00990.1 - 1.1e-57 194.7 2.1 1.1e-57 194.7 1.5 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFX00990.1 - 5.3e-44 149.9 8.4 5.3e-44 149.9 5.8 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFX00990.1 - 1.6e-27 97.3 0.0 5e-27 95.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX00990.1 - 1.6e-15 56.8 0.0 3e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EFX00990.1 - 2.6e-15 57.0 0.0 6e-15 55.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase APG12 PF04110.8 EFX00990.1 - 8.2e-09 35.5 0.0 3e-08 33.7 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like autophagy protein Apg12 Cation_ATPase_N PF00690.21 EFX00990.1 - 7.6e-07 28.5 0.2 3.2e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EFX00990.1 - 0.0001 21.9 0.2 0.00019 21.0 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Transthyretin PF00576.16 EFX00991.1 - 1.2e-24 86.3 0.0 9.3e-15 54.4 0.1 2.5 1 1 1 2 2 2 2 HIUase/Transthyretin family FixH PF05751.6 EFX00991.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 2 0 0 2 2 2 0 FixH POT1 PF02765.12 EFX00992.1 - 8.4e-12 45.2 0.0 1.6e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Cation_efflux PF01545.16 EFX00993.1 - 1.9e-18 66.5 5.6 4.9e-18 65.2 3.9 1.6 1 1 0 1 1 1 1 Cation efflux family Tubulin PF00091.20 EFX00994.1 - 8e-72 241.5 0.0 1.3e-71 240.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFX00994.1 - 3.4e-49 166.0 0.1 5.5e-49 165.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 EFX00994.1 - 4.4e-06 26.7 0.0 9.1e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 EFX00994.1 - 0.0025 17.3 0.0 0.0046 16.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain zf-TFIIB PF13453.1 EFX00995.1 - 0.025 13.7 0.9 1.5 8.1 0.0 2.1 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-RING_3 PF14369.1 EFX00995.1 - 0.28 11.2 0.3 0.28 11.2 0.2 2.5 2 1 1 3 3 3 0 zinc-finger DUF1660 PF07874.6 EFX00995.1 - 0.48 10.7 4.8 2.1 8.7 0.2 2.1 1 1 1 2 2 2 0 Prophage protein (DUF1660) Zn_Tnp_IS1 PF03811.8 EFX00995.1 - 1.2 8.6 4.2 4.6 6.8 2.9 1.9 1 1 0 1 1 1 0 InsA N-terminal domain Carla_C4 PF01623.12 EFX00995.1 - 2.8 7.7 7.0 2.9 7.6 0.7 2.1 1 1 1 2 2 2 0 Carlavirus putative nucleic acid binding protein ADH_N PF08240.7 EFX00996.1 - 8.4e-29 99.5 0.7 2e-28 98.3 0.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX00996.1 - 8.2e-17 60.9 0.2 1.6e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 EFX00996.1 - 0.018 14.4 0.2 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.16 EFX00996.1 - 0.084 12.6 0.1 0.75 9.6 0.1 2.2 2 0 0 2 2 2 0 ThiF family Ribosomal_S21e PF01249.13 EFX00997.1 - 1.2e-38 130.8 0.1 1.4e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e DUF572 PF04502.8 EFX00998.1 - 1.4e-36 126.3 0.0 1.7e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Cut8_N PF14482.1 EFX00998.1 - 0.11 12.4 0.0 2.4 8.2 0.0 2.5 2 0 0 2 2 2 0 Cut8 proteasome-binding domain Pkinase PF00069.20 EFX00999.1 - 1.4e-70 237.4 0.7 3.2e-70 236.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX00999.1 - 3.1e-45 154.2 0.0 3.1e-45 154.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.23 EFX00999.1 - 1.4e-16 60.6 0.0 1.4e-16 60.6 0.0 2.9 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 EFX00999.1 - 4.2e-08 32.5 0.0 1e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFX00999.1 - 0.1 12.3 11.9 0.13 12.0 0.0 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family DSHCT PF08148.7 EFX00999.1 - 0.12 11.6 1.6 0.24 10.6 0.0 2.1 2 0 0 2 2 2 0 DSHCT (NUC185) domain Sec7 PF01369.15 EFX01000.1 - 4.3e-41 140.6 0.1 7.8e-41 139.8 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH PF00169.24 EFX01000.1 - 8e-07 29.2 0.0 2.1e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 EFX01000.1 - 2.3e-05 24.5 0.0 5.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF924 PF06041.6 EFX01000.1 - 0.057 13.1 1.8 9.2 5.9 0.1 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF924) Pkinase PF00069.20 EFX01001.1 - 1.9e-65 220.6 0.0 2.3e-65 220.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01001.1 - 2.3e-31 108.8 0.0 3e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX01001.1 - 0.024 13.6 0.0 0.057 12.3 0.0 1.6 1 1 0 1 1 1 0 Kinase-like DUF2408 PF10303.4 EFX01002.1 - 1.2e-40 138.7 1.3 2.3e-28 98.9 0.0 4.9 3 2 2 5 5 5 4 Protein of unknown function (DUF2408) Dna2 PF08696.6 EFX01003.1 - 7.2e-68 228.0 0.0 1.1e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.1 EFX01003.1 - 7.4e-52 175.6 0.0 1.2e-51 174.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFX01003.1 - 8.8e-41 140.0 0.1 2e-20 73.3 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.1 EFX01003.1 - 9.2e-13 47.7 1.0 3.5e-12 45.9 0.1 2.5 2 0 0 2 2 1 1 Part of AAA domain AAA_30 PF13604.1 EFX01003.1 - 1.6e-12 47.3 0.0 1.6e-11 44.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.2 EFX01003.1 - 3.5e-09 36.4 0.0 7.9e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.12 EFX01003.1 - 5.4e-09 36.1 0.0 6.4e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.13 EFX01003.1 - 3.7e-06 26.6 0.1 0.28 10.6 0.0 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 EFX01003.1 - 0.0004 19.7 0.1 0.00068 19.0 0.1 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.17 EFX01003.1 - 0.00041 19.8 0.1 0.00075 18.9 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MobB PF03205.9 EFX01003.1 - 0.00046 19.8 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Helicase_RecD PF05127.9 EFX01003.1 - 0.00053 19.6 0.0 0.0018 17.9 0.0 1.9 1 1 0 1 1 1 1 Helicase CbiA PF01656.18 EFX01003.1 - 0.00089 18.7 0.0 0.0022 17.4 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.1 EFX01003.1 - 0.0033 16.8 0.0 0.076 12.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFX01003.1 - 0.0037 17.2 0.0 0.0037 17.2 0.0 2.5 3 0 0 3 3 2 1 AAA ATPase domain T2SE PF00437.15 EFX01003.1 - 0.01 14.7 0.0 0.018 13.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 EFX01003.1 - 0.028 14.5 0.0 0.11 12.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.9 EFX01003.1 - 0.031 13.2 0.0 0.4 9.5 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase DUF87 PF01935.12 EFX01003.1 - 0.048 13.4 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF87 IstB_IS21 PF01695.12 EFX01003.1 - 0.071 12.5 0.0 0.24 10.7 0.0 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.10 EFX01003.1 - 0.073 12.8 0.1 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_10 PF12846.2 EFX01003.1 - 0.091 12.1 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain NTPase_1 PF03266.10 EFX01003.1 - 0.14 11.8 0.4 0.45 10.2 0.1 1.9 2 0 0 2 2 1 0 NTPase AAA PF00004.24 EFX01003.1 - 0.16 12.1 0.1 0.42 10.8 0.1 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1413 PF07205.6 EFX01003.1 - 0.38 10.3 0.1 0.88 9.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1413) adh_short PF00106.20 EFX01004.1 - 5.6e-25 88.1 1.8 8.3e-25 87.6 1.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01004.1 - 1.5e-19 70.7 0.0 2.2e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01004.1 - 3.8e-08 33.2 0.6 7.1e-08 32.3 0.4 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX01004.1 - 3.3e-07 29.9 0.6 1.1e-06 28.2 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Orthopox_C10L PF07020.6 EFX01004.1 - 0.0018 18.7 0.8 0.093 13.2 0.1 2.4 2 0 0 2 2 2 1 Orthopoxvirus C10L protein 3Beta_HSD PF01073.14 EFX01004.1 - 0.0038 15.9 0.1 0.0051 15.5 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Eno-Rase_NADH_b PF12242.3 EFX01004.1 - 0.11 12.2 2.3 0.15 11.8 0.1 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 EFX01004.1 - 0.23 11.4 3.3 0.53 10.2 2.2 1.5 1 1 0 1 1 1 0 NADH(P)-binding Methyltransf_16 PF10294.4 EFX01005.1 - 5.6e-21 74.7 0.0 8.4e-21 74.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EFX01005.1 - 3.1e-05 24.5 0.0 6.5e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX01005.1 - 0.00036 19.9 0.0 0.00065 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EFX01005.1 - 0.0023 17.0 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 EFX01005.1 - 0.012 15.2 0.1 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFX01005.1 - 0.013 15.0 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 EFX01005.1 - 0.027 14.9 0.1 0.059 13.8 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01005.1 - 0.047 13.4 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 EFX01005.1 - 0.057 13.0 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_26 PF13659.1 EFX01005.1 - 0.098 12.6 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PNP_UDP_1 PF01048.15 EFX01006.1 - 3.8e-37 127.5 1.4 5.3e-37 127.0 1.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily Flavin_Reduct PF01613.13 EFX01007.1 - 1.8e-25 89.6 0.0 2.4e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain PAS_5 PF07310.8 EFX01007.1 - 0.035 13.6 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 PAS domain Ferric_reduct PF01794.14 EFX01008.1 - 4.4e-17 62.3 8.4 4.4e-17 62.3 5.8 2.6 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EFX01008.1 - 5e-17 62.2 0.0 1.2e-16 61.0 0.0 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFX01008.1 - 9.8e-15 54.3 0.0 2.6e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 EFX01008.1 - 0.00011 22.6 0.0 0.34 11.4 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF2975 PF11188.3 EFX01008.1 - 0.0024 17.6 8.5 0.0052 16.5 0.8 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF2975) Cation_efflux PF01545.16 EFX01008.1 - 0.04 12.9 1.8 0.05 12.6 0.4 1.8 2 0 0 2 2 2 0 Cation efflux family EpsG PF14897.1 EFX01008.1 - 0.1 11.4 10.1 0.013 14.4 3.7 1.8 1 1 0 1 1 1 0 EpsG family UreD PF01774.12 EFX01009.1 - 7.1e-51 172.6 0.1 9e-51 172.3 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein Pantoate_transf PF02548.10 EFX01010.1 - 4.5e-102 340.6 0.3 5.4e-102 340.3 0.2 1.1 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 EFX01010.1 - 4.9e-08 32.4 5.2 1.1e-07 31.2 3.6 1.6 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Ifi-6-16 PF06140.8 EFX01011.1 - 1.4e-08 34.4 25.7 1.4e-08 34.4 17.8 3.6 1 1 2 3 3 3 1 Interferon-induced 6-16 family zf-AN1 PF01428.11 EFX01012.1 - 1.9e-11 43.6 13.0 2.6e-11 43.1 9.0 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger Metallothio_Euk PF12749.2 EFX01012.1 - 4.3 7.4 8.9 19 5.3 6.2 1.9 1 1 0 1 1 1 0 Eukaryotic metallothionein CK_II_beta PF01214.13 EFX01013.1 - 1.7e-72 242.8 0.1 2.1e-72 242.5 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Dynamin_M PF01031.15 EFX01014.1 - 1e-104 349.4 0.0 1.8e-104 348.7 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 EFX01014.1 - 7.2e-56 188.6 0.0 1.2e-55 187.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 EFX01014.1 - 6.9e-29 99.5 4.2 6.9e-29 99.5 2.9 2.4 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EFX01014.1 - 0.00022 21.1 0.7 0.003 17.4 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 EFX01014.1 - 0.0085 16.5 0.0 0.028 14.9 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein BRAP2 PF07576.7 EFX01016.1 - 2.5e-18 65.6 0.0 5e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.14 EFX01016.1 - 5.2e-17 61.7 6.8 1.2e-16 60.5 4.7 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Acyltransferase PF01553.16 EFX01016.1 - 4.3e-10 39.1 0.0 0.00046 19.6 0.0 3.1 3 0 0 3 3 3 2 Acyltransferase zf-RING_2 PF13639.1 EFX01016.1 - 8.8e-09 35.0 10.2 8.8e-09 35.0 7.1 2.3 3 0 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.1 EFX01016.1 - 4.4e-05 23.1 7.1 0.00012 21.7 4.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFX01016.1 - 0.00036 20.1 8.4 0.00077 19.0 5.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX01016.1 - 0.0021 18.0 9.2 0.0021 18.0 6.4 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX01016.1 - 0.0046 16.5 6.9 0.0046 16.5 4.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFX01016.1 - 0.0073 16.0 3.9 0.036 13.7 2.9 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 EFX01016.1 - 0.0099 15.9 5.8 0.0099 15.9 4.0 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 EFX01016.1 - 0.015 15.0 3.1 0.056 13.2 2.1 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 EFX01016.1 - 0.039 13.7 6.1 0.11 12.3 4.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger MttA_Hcf106 PF02416.11 EFX01016.1 - 0.15 11.2 0.0 0.4 9.8 0.0 1.7 1 0 0 1 1 1 0 mttA/Hcf106 family Baculo_FP PF03258.9 EFX01016.1 - 0.26 10.3 0.2 0.87 8.6 0.0 1.9 2 0 0 2 2 2 0 Baculovirus FP protein eIF3_N PF09440.5 EFX01016.1 - 1.4 9.0 5.8 12 6.0 0.5 2.6 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain Prok-RING_4 PF14447.1 EFX01016.1 - 7.9 6.1 9.0 94 2.6 0.1 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Init_tRNA_PT PF04179.7 EFX01017.1 - 1.2e-118 396.8 0.0 2.4e-118 395.8 0.0 1.5 1 1 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase RFX_DNA_binding PF02257.10 EFX01018.1 - 8.3e-29 99.5 0.0 1.8e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain SIR2 PF02146.12 EFX01019.1 - 5.5e-58 195.6 0.0 9.3e-58 194.8 0.0 1.4 1 0 0 1 1 1 1 Sir2 family SHD1 PF03983.7 EFX01019.1 - 8.2e-35 118.2 0.1 1.4e-34 117.5 0.1 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.23 EFX01019.1 - 4.4e-32 109.2 5.5 7e-11 41.3 0.0 4.3 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.1 EFX01019.1 - 4.5e-32 109.3 9.1 7.3e-10 38.2 0.3 4.1 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 EFX01019.1 - 3.1e-21 74.6 0.3 6.7e-07 28.7 0.0 4.5 4 0 0 4 4 4 3 Variant SH3 domain SH3_3 PF08239.6 EFX01019.1 - 0.00051 20.1 6.0 0.0017 18.4 0.4 3.3 3 0 0 3 3 3 1 Bacterial SH3 domain DUF1720 PF08226.6 EFX01019.1 - 0.0016 18.4 39.7 0.0016 18.4 27.5 5.7 2 1 2 5 5 5 2 Domain of unknown function (DUF1720) DUF592 PF04574.8 EFX01019.1 - 0.0062 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 EFX01019.1 - 0.046 13.4 0.1 6 6.6 0.0 2.6 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain PEX11 PF05648.9 EFX01020.1 - 8.5e-13 48.0 0.2 1.8e-08 33.9 0.0 3.6 3 1 0 3 3 3 3 Peroxisomal biogenesis factor 11 (PEX11) Dor1 PF04124.7 EFX01021.1 - 4.3e-45 153.6 0.0 3.2e-41 140.9 0.0 2.3 1 1 1 2 2 2 2 Dor1-like family RRM_1 PF00076.17 EFX01022.1 - 3.8e-37 125.7 0.2 1.3e-17 63.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01022.1 - 9.9e-28 95.9 0.0 4.7e-13 48.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01022.1 - 2.7e-11 43.1 0.1 2.1e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OmpH PF03938.9 EFX01022.1 - 0.00034 20.5 14.2 0.00076 19.4 9.9 1.6 1 1 0 1 1 1 1 Outer membrane protein (OmpH-like) Nup35_RRM_2 PF14605.1 EFX01022.1 - 0.005 16.5 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4407 PF14362.1 EFX01022.1 - 0.85 8.5 10.2 1.2 7.9 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Suf PF05843.9 EFX01022.1 - 6.7 6.3 12.1 12 5.5 8.4 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CDK2AP PF09806.4 EFX01022.1 - 7.4 6.7 13.6 12 6.0 7.9 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein PAS PF00989.19 EFX01023.1 - 0.00068 19.3 0.0 0.0018 18.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.13 EFX01023.1 - 0.0075 16.1 8.6 0.0075 16.1 6.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3783 PF12646.2 EFX01024.1 - 0.0023 17.6 0.2 0.023 14.4 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3783) DUF3015 PF11220.3 EFX01024.1 - 0.062 12.8 0.1 0.14 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) FH2 PF02181.18 EFX01024.1 - 0.1 11.4 2.2 0.076 11.8 0.3 1.6 2 0 0 2 2 2 0 Formin Homology 2 Domain SOG2 PF10428.4 EFX01024.1 - 0.21 10.1 3.3 1 7.9 0.7 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein EF-hand_1 PF00036.27 EFX01025.1 - 3.2e-41 135.4 12.9 1.1e-09 36.9 0.6 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 EFX01025.1 - 6.3e-37 125.5 5.4 2.7e-20 72.2 0.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 EFX01025.1 - 3.2e-35 119.5 11.9 3e-16 58.7 0.4 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 EFX01025.1 - 3e-30 101.3 9.0 1.2e-09 37.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 EFX01025.1 - 5.2e-26 88.7 9.7 1.4e-06 27.3 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 EFX01025.1 - 9e-16 57.5 0.3 2.2e-08 33.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 EFX01025.1 - 6.3e-09 35.5 1.7 0.0016 18.1 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 EFX01025.1 - 1.2e-08 34.9 0.1 0.003 17.5 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 EFX01025.1 - 4.7e-08 32.5 0.1 0.022 14.3 0.0 3.3 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 EFX01025.1 - 4.6e-07 29.7 2.2 4.5e-06 26.5 0.3 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.8 EFX01025.1 - 5.7e-05 22.8 0.5 0.3 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.8 EFX01025.1 - 0.00023 20.7 0.5 0.033 13.7 0.3 2.9 1 1 0 1 1 1 1 Caleosin related protein Tenui_NCP PF04876.7 EFX01025.1 - 0.0024 17.4 0.1 0.14 11.7 0.0 2.2 1 1 1 2 2 2 1 Tenuivirus major non-capsid protein Toprim_2 PF13155.1 EFX01025.1 - 0.0085 16.3 1.3 2.5 8.4 0.0 2.5 1 1 1 2 2 2 1 Toprim-like RNA_pol_Rpb4 PF03874.11 EFX01025.1 - 0.0085 16.0 0.9 3.9 7.4 0.0 2.6 3 0 0 3 3 3 2 RNA polymerase Rpb4 DUF3349 PF11829.3 EFX01025.1 - 0.023 15.1 0.4 10 6.6 0.1 2.9 1 1 3 4 4 4 0 Protein of unknown function (DUF3349) DUF2267 PF10025.4 EFX01025.1 - 0.069 13.2 0.0 14 5.7 0.0 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) EF-hand_10 PF14788.1 EFX01025.1 - 0.12 12.0 2.3 0.84 9.3 0.1 3.1 1 1 3 4 4 4 0 EF hand PB1 PF00564.19 EFX01025.1 - 0.22 11.2 2.3 27 4.5 0.1 3.3 2 1 1 3 3 3 0 PB1 domain RloB PF13707.1 EFX01025.1 - 0.39 10.3 4.4 3.9 7.0 3.0 2.3 1 1 0 1 1 1 0 RloB-like protein Zn_clus PF00172.13 EFX01026.1 - 2 8.3 11.4 0.15 11.9 3.8 2.3 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain BAF1_ABF1 PF04684.8 EFX01026.1 - 4 6.1 14.4 7 5.3 10.0 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Glyco_hydro_3 PF00933.16 EFX01027.1 - 5.5e-88 294.8 0.0 7.9e-88 294.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX01027.1 - 5.6e-45 153.6 0.1 5.3e-44 150.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX01027.1 - 5.1e-22 77.6 0.1 9e-22 76.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Flavoprotein PF02441.14 EFX01028.1 - 5.6e-29 100.4 0.1 9.1e-29 99.7 0.1 1.3 1 0 0 1 1 1 1 Flavoprotein Uds1 PF15456.1 EFX01029.1 - 5.5e-33 113.6 8.7 5.5e-33 113.6 6.0 2.2 2 0 0 2 2 2 1 Up-regulated During Septation Wbp11 PF09429.5 EFX01029.1 - 0.11 12.4 0.2 0.11 12.4 0.1 2.5 3 0 0 3 3 3 0 WW domain binding protein 11 DnaJ PF00226.26 EFX01030.1 - 4.8e-26 90.2 4.1 7.6e-26 89.6 2.8 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EFX01030.1 - 2.1e-19 69.1 3.2 9e-18 63.9 0.1 2.7 2 1 0 2 2 2 2 DnaJ C terminal domain WD40 PF00400.27 EFX01031.1 - 3.1e-30 102.9 12.4 5.7e-09 35.5 0.1 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat CLTH PF10607.4 EFX01031.1 - 0.0046 16.6 0.0 0.0081 15.8 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain PD40 PF07676.7 EFX01031.1 - 0.031 13.9 0.4 32 4.3 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF290 PF01060.18 EFX01031.1 - 0.04 13.9 0.2 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 Transthyretin-like family Abhydrolase_6 PF12697.2 EFX01033.1 - 2.8e-22 79.7 0.2 3.3e-22 79.5 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX01033.1 - 1.9e-14 53.6 0.4 4.9e-14 52.3 0.3 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX01033.1 - 5.4e-10 39.2 0.0 1.1e-09 38.2 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 EFX01033.1 - 0.00018 21.0 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Thioesterase PF00975.15 EFX01033.1 - 0.00021 21.5 0.1 0.00038 20.7 0.1 1.4 1 1 0 1 1 1 1 Thioesterase domain DUF1057 PF06342.7 EFX01033.1 - 0.0039 16.0 0.0 0.0055 15.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.3 EFX01033.1 - 0.014 15.1 0.1 0.068 13.0 0.0 2.0 2 0 0 2 2 2 0 Putative lysophospholipase UPF0227 PF05728.7 EFX01033.1 - 0.015 15.0 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DLH PF01738.13 EFX01033.1 - 0.03 13.6 0.0 0.077 12.2 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 EFX01033.1 - 0.043 13.2 0.9 4.9 6.5 0.1 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase DUF676 PF05057.9 EFX01033.1 - 0.081 12.2 0.1 0.16 11.2 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) zf-RING_2 PF13639.1 EFX01034.1 - 3e-08 33.3 11.9 5.6e-08 32.4 8.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFX01034.1 - 1.1e-07 31.4 9.7 1.1e-07 31.4 6.7 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX01034.1 - 1.2e-07 31.6 11.1 2.5e-07 30.6 7.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX01034.1 - 1.3e-07 31.1 10.7 2.4e-07 30.2 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX01034.1 - 3.7e-05 23.3 10.9 6.6e-05 22.5 7.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Helicase_C PF00271.26 EFX01034.1 - 0.00013 21.7 0.0 0.00037 20.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-rbx1 PF12678.2 EFX01034.1 - 0.00025 21.0 12.2 0.00072 19.6 8.5 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger Prok-RING_4 PF14447.1 EFX01034.1 - 0.0054 16.2 5.1 0.012 15.0 3.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.1 EFX01034.1 - 0.025 14.4 9.7 0.05 13.4 6.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 EFX01034.1 - 0.17 11.5 9.1 0.043 13.4 3.8 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 EFX01034.1 - 0.17 11.7 6.8 0.35 10.7 4.5 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger IBR PF01485.16 EFX01034.1 - 0.65 9.9 6.3 1.9 8.4 4.3 1.8 1 0 0 1 1 1 0 IBR domain DZR PF12773.2 EFX01034.1 - 1.6 8.5 7.1 6 6.7 4.9 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_UBOX PF13445.1 EFX01034.1 - 3.5 7.4 11.5 0.84 9.4 4.9 2.3 2 0 0 2 2 2 0 RING-type zinc-finger PMSR PF01625.16 EFX01035.1 - 3.9e-55 186.0 0.2 7e-55 185.1 0.1 1.3 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Rad60-SLD_2 PF13881.1 EFX01036.1 - 4.5e-05 23.2 0.0 0.00025 20.9 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EFX01036.1 - 0.00027 20.2 0.0 0.00052 19.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 EFX01036.1 - 0.0027 17.8 0.0 0.0057 16.8 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain XLF PF09302.6 EFX01037.1 - 2e-24 86.2 0.0 3.8e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 XLF (XRCC4-like factor) Fungal_trans PF04082.13 EFX01037.1 - 1.8e-19 69.6 0.0 2.9e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01037.1 - 1.5e-08 34.3 10.0 2.4e-08 33.7 6.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-I PF07778.6 EFX01038.1 - 2.9e-110 368.8 0.0 4e-110 368.4 0.0 1.1 1 0 0 1 1 1 1 Mis6 T2SM PF04612.7 EFX01039.1 - 0.33 10.7 4.7 0.64 9.7 3.2 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Pex2_Pex12 PF04757.9 EFX01040.1 - 2.7e-39 134.9 0.1 4.1e-39 134.3 0.1 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-primase PF09329.6 EFX01040.1 - 3.1e-17 61.9 0.8 5.2e-17 61.1 0.6 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.20 EFX01040.1 - 0.024 14.4 0.0 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain zf-C3HC4_4 PF15227.1 EFX01040.1 - 0.14 12.0 3.6 0.27 11.1 2.5 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EFX01040.1 - 0.3 11.1 6.3 0.079 12.9 1.6 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3405 PF11885.3 EFX01041.1 - 4.4e-177 589.2 0.0 5.6e-177 588.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) DUF3515 PF12028.3 EFX01041.1 - 0.025 13.7 0.0 7.6 5.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3515) SspP PF08179.7 EFX01041.1 - 0.075 13.2 0.1 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Small acid-soluble spore protein P family Methyltransf_23 PF13489.1 EFX01042.1 - 2e-17 63.4 0.0 2.9e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX01042.1 - 4.1e-09 36.8 0.0 9.2e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01042.1 - 8.6e-07 29.5 0.0 2.2e-05 24.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX01042.1 - 1.4e-06 28.7 0.0 1.2e-05 25.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX01042.1 - 0.00081 18.9 0.0 0.018 14.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFX01042.1 - 0.011 15.1 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.13 EFX01042.1 - 0.016 14.3 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EFX01042.1 - 0.048 12.6 0.0 0.11 11.4 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.14 EFX01042.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase UAA PF08449.6 EFX01043.1 - 1.6e-98 329.3 0.3 1.9e-98 329.1 0.2 1.0 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.10 EFX01043.1 - 3.3e-06 26.3 1.4 3.9e-06 26.1 0.0 1.7 2 0 0 2 2 2 1 Nucleotide-sugar transporter EmrE PF13536.1 EFX01043.1 - 0.00071 19.7 17.3 0.00089 19.4 1.9 3.4 3 1 1 4 4 4 2 Multidrug resistance efflux transporter DUF914 PF06027.7 EFX01043.1 - 0.037 12.8 1.9 1.2 7.8 0.5 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 EFX01043.1 - 0.16 12.0 29.3 0.35 10.9 2.1 3.9 3 2 1 5 5 5 0 EamA-like transporter family Vps39_2 PF10367.4 EFX01044.1 - 7e-08 32.6 0.0 1.5e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.4 EFX01044.1 - 0.012 15.5 0.0 0.069 13.1 0.0 2.2 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 RRM_5 PF13893.1 EFX01045.1 - 3.9e-10 39.4 0.0 5.9e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX01045.1 - 2e-07 30.5 0.0 4.7e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01045.1 - 3e-06 27.1 0.0 5.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.7 EFX01045.1 - 0.001 18.7 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 Calcipressin Limkain-b1 PF11608.3 EFX01045.1 - 0.055 13.2 0.0 0.055 13.2 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 Ribosomal_60s PF00428.14 EFX01045.1 - 5.4 7.4 11.9 14 6.1 8.2 1.7 1 1 0 1 1 1 0 60s Acidic ribosomal protein Abhydrolase_6 PF12697.2 EFX01046.1 - 8.5e-33 114.1 0.4 1.1e-32 113.8 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX01046.1 - 1.4e-16 60.7 0.2 2.3e-15 56.7 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX01046.1 - 8.6e-15 54.7 0.0 1.7e-14 53.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX01046.1 - 9.9e-07 28.5 0.1 1.6e-05 24.6 0.1 2.2 1 1 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.15 EFX01046.1 - 6.7e-05 23.2 0.0 7.3e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.3 EFX01046.1 - 0.0018 18.0 0.1 0.0044 16.8 0.0 1.6 2 0 0 2 2 2 1 Putative lysophospholipase Lipase_3 PF01764.20 EFX01046.1 - 0.0019 17.8 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.15 EFX01046.1 - 0.0023 17.4 0.0 0.0035 16.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase UPF0227 PF05728.7 EFX01046.1 - 0.0069 16.1 0.0 0.009 15.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) DUF915 PF06028.6 EFX01046.1 - 0.0075 15.3 0.0 2.1 7.3 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Ndr PF03096.9 EFX01046.1 - 0.009 14.5 0.0 0.016 13.6 0.0 1.4 1 0 0 1 1 1 1 Ndr family DLH PF01738.13 EFX01046.1 - 0.013 14.7 0.0 0.13 11.5 0.0 2.1 1 1 0 1 1 1 0 Dienelactone hydrolase family Chlorophyllase2 PF12740.2 EFX01046.1 - 0.026 13.3 0.0 0.046 12.6 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.6 EFX01046.1 - 0.05 12.3 0.0 0.078 11.7 0.0 1.4 1 1 0 1 1 1 0 Chlorophyllase Abhydrolase_3 PF07859.8 EFX01046.1 - 0.053 13.0 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF676 PF05057.9 EFX01046.1 - 0.056 12.7 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF900 PF05990.7 EFX01046.1 - 0.079 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_2 PF02230.11 EFX01046.1 - 0.13 11.6 0.0 9.9 5.5 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase LCAT PF02450.10 EFX01046.1 - 0.14 11.1 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase CAP_N PF01213.14 EFX01047.1 - 9 5.4 5.5 15 4.7 3.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Asp_protease PF09668.5 EFX01048.1 - 4.6e-60 200.6 0.3 6.3e-60 200.1 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 EFX01048.1 - 9.9e-13 48.4 1.1 2.4e-12 47.1 0.0 2.2 2 1 2 4 4 4 1 Aspartyl protease UBA PF00627.26 EFX01048.1 - 1.1e-09 37.7 0.0 2.8e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain gag-asp_proteas PF13975.1 EFX01048.1 - 7.3e-09 35.3 0.0 2.1e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 EFX01048.1 - 1.2e-06 28.5 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 EFX01048.1 - 2.5e-05 24.1 0.0 9.3e-05 22.2 0.0 2.0 1 1 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.1 EFX01048.1 - 0.016 14.7 0.0 0.038 13.5 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain RuvA_C PF07499.8 EFX01048.1 - 0.025 14.7 0.4 0.19 11.9 0.0 2.5 2 0 0 2 2 2 0 RuvA, C-terminal domain UCH PF00443.24 EFX01049.1 - 4.2e-24 85.1 0.0 5.6e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EFX01049.1 - 1.3e-11 44.4 0.3 2.2e-11 43.6 0.2 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 EFX01049.1 - 0.1 11.9 0.0 9.4 5.5 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Cation_efflux PF01545.16 EFX01050.1 - 0.2 10.6 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Cation efflux family Trypan_PARP PF05887.6 EFX01050.1 - 1.1 9.0 11.7 1 9.2 0.9 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF3384 PF11864.3 EFX01051.1 - 5.5e-79 265.7 0.0 4.1e-77 259.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3384) Rap_GAP PF02145.10 EFX01051.1 - 1.1e-54 184.6 0.0 1.8e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.11 EFX01051.1 - 2e-30 106.0 0.1 6.8e-29 101.0 0.0 2.3 2 0 0 2 2 2 1 Tuberin UNC45-central PF11701.3 EFX01051.1 - 0.22 11.1 2.5 3.6 7.2 0.0 3.3 5 0 0 5 5 5 0 Myosin-binding striated muscle assembly central Med13_C PF06333.7 EFX01052.1 - 4.2e-83 279.2 0.0 1.3e-82 277.6 0.0 1.8 2 0 0 2 2 2 1 Mediator complex subunit 13 C-terminal Med13_N PF11597.3 EFX01052.1 - 1e-18 67.2 0.0 8.3e-18 64.2 0.0 2.1 1 1 0 1 1 1 1 Mediator complex subunit 13 N-terminal NOA36 PF06524.7 EFX01052.1 - 0.31 10.2 0.7 0.47 9.6 0.5 1.2 1 0 0 1 1 1 0 NOA36 protein Abhydrolase_6 PF12697.2 EFX01053.1 - 1.1e-18 67.9 1.5 1.6e-18 67.4 1.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EFX01053.1 - 2.8e-17 62.3 0.0 5.7e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 EFX01053.1 - 1.6e-12 47.3 0.1 2.3e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX01053.1 - 0.0032 17.0 0.0 0.0049 16.4 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.15 EFX01053.1 - 0.007 15.9 0.3 0.018 14.6 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF900 PF05990.7 EFX01053.1 - 0.035 13.4 0.0 5.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Porin_3 PF01459.17 EFX01055.1 - 3.6e-79 265.8 0.1 4.2e-79 265.6 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin MFS_1 PF07690.11 EFX01056.1 - 1.7e-24 86.1 33.3 1.7e-24 86.1 23.1 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily FAD_binding_4 PF01565.18 EFX01057.1 - 8.1e-13 48.0 0.4 1.4e-12 47.3 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Glyco_transf_15 PF01793.11 EFX01058.1 - 1.3e-136 454.9 3.8 1.5e-136 454.7 2.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Piwi PF02171.12 EFX01059.1 - 8.8e-70 235.0 0.0 1.9e-69 233.9 0.0 1.5 2 0 0 2 2 2 1 Piwi domain DUF1785 PF08699.5 EFX01059.1 - 1.1e-12 47.1 0.4 3.7e-12 45.4 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1785) PAZ PF02170.17 EFX01059.1 - 2.5e-09 36.5 0.0 4.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 PAZ domain HMG_box PF00505.14 EFX01060.1 - 3.1e-09 36.9 3.0 5.7e-09 36.1 2.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFX01060.1 - 8.3e-06 26.0 2.9 1.7e-05 25.0 2.0 1.6 1 0 0 1 1 1 1 HMG-box domain MAT_Alpha1 PF04769.7 EFX01060.1 - 0.0084 15.4 0.1 0.015 14.6 0.1 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 GPAT_N PF14829.1 EFX01060.1 - 0.073 12.7 0.1 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal Phosphoesterase PF04185.9 EFX01061.1 - 7.9e-67 226.0 3.3 1.1e-66 225.6 2.3 1.1 1 0 0 1 1 1 1 Phosphoesterase family zf-Nse PF11789.3 EFX01062.1 - 3.1e-19 68.2 0.8 5.9e-19 67.3 0.2 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 EFX01062.1 - 2.8e-06 27.2 0.0 6.3e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-MIZ PF02891.15 EFX01062.1 - 0.018 14.5 0.5 0.033 13.6 0.3 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.1 EFX01062.1 - 0.033 13.9 0.4 0.088 12.5 0.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.1 EFX01062.1 - 0.086 12.6 0.1 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 EFX01062.1 - 0.73 9.9 2.2 0.51 10.4 0.4 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ecm33 PF12454.3 EFX01063.1 - 1.5e-09 37.5 2.1 6.3e-09 35.5 1.4 2.2 1 0 0 1 1 1 1 GPI-anchored cell wall organization protein Recep_L_domain PF01030.19 EFX01063.1 - 1.2e-07 31.6 3.8 0.23 11.4 0.5 4.0 2 1 2 4 4 4 3 Receptor L domain Clathrin_lg_ch PF01086.12 EFX01064.1 - 4.5e-66 223.0 8.2 5.1e-66 222.8 5.7 1.0 1 0 0 1 1 1 1 Clathrin light chain Metallophos PF00149.23 EFX01065.1 - 2.3e-11 43.4 2.7 1.4e-09 37.6 0.8 2.9 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase ESSS PF10183.4 EFX01067.1 - 3.2e-26 91.7 0.6 4e-26 91.4 0.3 1.3 1 1 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Vps5 PF09325.5 EFX01068.1 - 5.7e-85 284.3 5.8 7.6e-85 283.9 4.0 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 EFX01068.1 - 1.6e-12 47.1 0.0 3.4e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.4 EFX01068.1 - 0.02 14.1 1.0 0.29 10.3 0.7 2.2 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein BAR PF03114.13 EFX01068.1 - 0.13 11.7 4.8 0.19 11.2 3.3 1.2 1 0 0 1 1 1 0 BAR domain CD99L2 PF12301.3 EFX01069.1 - 0.0004 20.1 0.1 0.00059 19.5 0.1 1.4 1 0 0 1 1 1 1 CD99 antigen like protein 2 PHO4 PF01384.15 EFX01069.1 - 0.02 13.5 0.0 0.02 13.5 0.0 1.0 1 0 0 1 1 1 0 Phosphate transporter family Wzy_C PF04932.10 EFX01069.1 - 0.13 12.0 0.4 0.44 10.3 0.1 1.9 2 0 0 2 2 2 0 O-Antigen ligase UPF0233 PF06781.7 EFX01069.1 - 0.14 11.7 0.1 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) Methyltransf_11 PF08241.7 EFX01070.1 - 4.4e-16 59.1 0.0 1.1e-15 57.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01070.1 - 6.8e-16 58.4 0.0 1e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX01070.1 - 7.4e-13 48.8 0.1 2.6e-12 47.0 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX01070.1 - 8.2e-13 48.2 0.0 3e-12 46.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01070.1 - 2.5e-11 44.1 0.1 5.4e-11 43.0 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFX01070.1 - 5.6e-11 42.0 0.0 7.7e-10 38.2 0.0 2.0 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 EFX01070.1 - 1.3e-08 35.1 0.1 6.1e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX01070.1 - 1.4e-08 34.7 0.1 2.6e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX01070.1 - 2.7e-05 23.3 0.0 5.6e-05 22.3 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.7 EFX01070.1 - 0.00085 18.6 0.0 0.0026 17.1 0.0 1.8 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase MTS PF05175.9 EFX01070.1 - 0.0026 17.1 0.3 0.36 10.1 0.2 2.2 2 0 0 2 2 2 1 Methyltransferase small domain ADH_zinc_N PF00107.21 EFX01070.1 - 0.018 14.5 0.3 0.12 11.9 0.1 2.3 2 1 0 2 2 2 0 Zinc-binding dehydrogenase Methyltransf_32 PF13679.1 EFX01070.1 - 0.031 13.9 0.1 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 EFX01070.1 - 0.043 13.1 0.3 0.15 11.4 0.3 1.8 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Frag1 PF10277.4 EFX01071.1 - 5.8e-39 133.7 9.4 6.9e-39 133.5 6.5 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF998 PF06197.8 EFX01071.1 - 0.00012 21.4 15.9 0.00014 21.2 10.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF998) TMEM173 PF15009.1 EFX01071.1 - 0.16 10.7 0.5 0.25 10.1 0.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 173 Aminotran_1_2 PF00155.16 EFX01072.1 - 3e-34 118.5 0.0 4.1e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EFX01072.1 - 0.015 14.3 0.2 0.025 13.5 0.2 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 EFX01072.1 - 0.057 11.6 0.0 0.084 11.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Peptidase_S28 PF05577.7 EFX01073.1 - 1.1e-45 155.9 1.1 8.1e-36 123.5 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Peptidase_S37 PF05576.6 EFX01073.1 - 7.6e-06 24.6 0.1 2e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 PS-10 peptidase S37 Abhydrolase_5 PF12695.2 EFX01073.1 - 0.024 14.3 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family AAL_decarboxy PF03306.8 EFX01073.1 - 0.18 10.8 0.0 17 4.3 0.0 2.4 2 0 0 2 2 2 0 Alpha-acetolactate decarboxylase V-ATPase_C PF03223.10 EFX01074.1 - 1.1e-103 347.0 0.1 8.8e-82 274.9 0.1 2.0 1 1 1 2 2 2 2 V-ATPase subunit C ArsA_ATPase PF02374.10 EFX01075.1 - 1.4e-110 369.1 0.0 1.6e-110 368.9 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 EFX01075.1 - 1.5e-16 60.4 0.1 8.1e-16 58.0 0.1 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EFX01075.1 - 7.6e-09 35.6 0.0 4.2e-08 33.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.13 EFX01075.1 - 4.8e-06 25.9 0.0 8.8e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 EFX01075.1 - 8.9e-05 22.0 0.0 0.0014 18.1 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_19 PF13245.1 EFX01075.1 - 0.011 15.4 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_25 PF13481.1 EFX01075.1 - 0.012 15.0 0.2 0.028 13.8 0.2 1.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EFX01075.1 - 0.022 14.1 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein MipZ PF09140.6 EFX01075.1 - 0.023 13.7 0.1 0.043 12.9 0.1 1.5 1 1 0 1 1 1 0 ATPase MipZ YhjQ PF06564.7 EFX01075.1 - 0.027 13.8 0.0 0.063 12.6 0.0 1.6 1 0 0 1 1 1 0 YhjQ protein NB-ARC PF00931.17 EFX01075.1 - 0.095 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.1 EFX01075.1 - 0.12 12.7 0.1 0.55 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EFX01075.1 - 0.13 11.1 0.0 0.39 9.5 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein ParA PF10609.4 EFX01075.1 - 0.13 12.1 0.3 0.55 10.1 0.1 2.0 2 0 0 2 2 2 0 ParA/MinD ATPase like SNARE PF05739.14 EFX01075.1 - 1.9 8.2 4.4 6.2 6.5 0.2 3.1 3 0 0 3 3 3 0 SNARE domain APH PF01636.18 EFX01076.1 - 0.00022 21.0 0.1 0.00022 21.0 0.1 3.0 3 1 1 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFX01076.1 - 0.0053 16.1 0.1 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 RIO1 family DUF29 PF01724.11 EFX01076.1 - 0.19 11.5 1.9 0.38 10.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF29 WWbp PF10349.4 EFX01078.1 - 2.3e-12 47.8 5.9 4.1e-12 47.0 4.1 1.4 1 0 0 1 1 1 1 WW-domain ligand protein GRAM PF02893.15 EFX01078.1 - 0.041 13.4 0.0 0.077 12.5 0.0 1.4 1 0 0 1 1 1 0 GRAM domain Tim17 PF02466.14 EFX01079.1 - 0.031 14.3 6.5 0.073 13.1 4.5 1.7 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Romo1 PF10247.4 EFX01079.1 - 0.43 10.8 5.5 1.3 9.2 0.3 2.8 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 HSP20 PF00011.16 EFX01080.1 - 2.2e-08 33.8 0.0 0.0056 16.5 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family Ribosomal_60s PF00428.14 EFX01080.1 - 0.98 9.8 17.4 6.3 7.2 6.9 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Mito_carr PF00153.22 EFX01081.1 - 1.5e-49 165.6 0.8 2.2e-17 62.5 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.11 EFX01082.1 - 1.6e-17 63.2 55.9 8.8e-10 37.8 25.8 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX01082.1 - 2.6e-06 25.9 25.2 3.5e-06 25.5 17.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4183 PF13799.1 EFX01082.1 - 0.056 13.2 0.3 0.32 10.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4183) P5-ATPase PF12409.3 EFX01083.1 - 1.3e-35 121.8 0.0 4.4e-35 120.1 0.0 2.0 2 0 0 2 2 2 1 P5-type ATPase cation transporter HAD PF12710.2 EFX01083.1 - 1.5e-29 103.5 0.0 3.2e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EFX01083.1 - 1.3e-23 83.3 0.0 1.7e-22 79.5 0.0 2.4 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EFX01083.1 - 3.5e-16 60.2 0.0 5.7e-11 43.2 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX01083.1 - 0.0045 16.9 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EFX01083.1 - 0.0046 16.3 0.0 0.014 14.8 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EFX01083.1 - 0.062 12.8 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase ADH_zinc_N_2 PF13602.1 EFX01084.1 - 1e-17 65.1 0.1 1.9e-17 64.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFX01084.1 - 3.7e-12 45.9 0.2 6.9e-12 45.0 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX01084.1 - 0.027 14.2 0.0 0.063 13.0 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Toxin_13 PF07822.6 EFX01084.1 - 0.13 12.1 0.3 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein KH_1 PF00013.24 EFX01085.1 - 1.9e-88 290.0 12.7 8.4e-14 50.9 0.1 12.8 14 0 0 14 14 14 9 KH domain KH_3 PF13014.1 EFX01085.1 - 6e-61 201.2 23.4 8.3e-10 38.0 0.0 12.4 13 0 0 13 13 13 7 KH domain SLS PF14611.1 EFX01085.1 - 2.7e-12 46.5 2.3 0.00033 20.1 0.0 6.5 5 3 3 8 8 8 3 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.12 EFX01085.1 - 1.2e-10 40.7 19.8 0.034 13.7 0.0 7.7 7 1 1 8 8 8 4 KH domain KH_4 PF13083.1 EFX01085.1 - 5.4e-07 29.1 1.4 0.2 11.2 0.0 5.9 5 0 0 5 5 5 2 KH domain NUDIX PF00293.23 EFX01086.1 - 2.5e-17 62.7 0.1 3.8e-17 62.1 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain Adaptin_N PF01602.15 EFX01087.1 - 4.7e-145 483.8 4.8 5.5e-145 483.6 3.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 EFX01087.1 - 3.4e-18 66.0 0.0 8e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.1 EFX01087.1 - 1.2e-05 25.4 2.3 0.31 11.3 0.0 4.5 3 3 0 4 4 4 2 HEAT repeats Cnd1 PF12717.2 EFX01087.1 - 2.6e-05 24.1 0.6 0.0056 16.5 0.2 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 EFX01087.1 - 0.00078 19.8 1.8 5.6 7.5 0.0 5.2 5 0 0 5 5 5 1 HEAT-like repeat RIX1 PF08167.7 EFX01087.1 - 0.0068 16.1 0.0 0.22 11.1 0.0 2.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis TIP120 PF08623.5 EFX01087.1 - 0.0076 15.8 1.0 0.077 12.5 0.1 2.8 2 1 1 3 3 3 1 TATA-binding protein interacting (TIP20) Arm PF00514.18 EFX01087.1 - 0.039 13.7 0.1 62 3.6 0.1 4.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT PF02985.17 EFX01087.1 - 0.043 13.9 5.6 17 5.8 0.0 5.5 6 1 1 7 7 7 0 HEAT repeat G-patch_2 PF12656.2 EFX01087.1 - 0.045 13.6 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 DExH-box splicing factor binding site AT_hook PF02178.14 EFX01088.1 - 0.015 14.8 34.2 0.077 12.7 3.1 5.0 4 0 0 4 4 4 0 AT hook motif COesterase PF00135.23 EFX01089.1 - 0.0057 15.4 0.0 0.0093 14.7 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family RRM_1 PF00076.17 EFX01090.1 - 4.9e-21 74.1 0.0 1.1e-20 72.9 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01090.1 - 3e-16 59.1 0.0 4.7e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01090.1 - 1.7e-12 46.9 0.0 2.7e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gemini_mov PF01708.11 EFX01091.1 - 0.0062 16.0 0.0 0.0085 15.6 0.0 1.2 1 0 0 1 1 1 1 Geminivirus putative movement protein Suc_Fer-like PF06999.7 EFX01092.1 - 7.1e-31 108.0 0.0 6e-27 95.1 0.0 2.1 2 0 0 2 2 2 2 Sucrase/ferredoxin-like DcpS_C PF11969.3 EFX01093.1 - 2.2e-14 53.6 0.0 6.7e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 EFX01093.1 - 3.7e-13 49.8 0.6 1.4e-12 47.9 0.4 1.9 1 1 0 1 1 1 1 HIT domain Mito_carr PF00153.22 EFX01094.1 - 5.4e-65 215.1 7.4 7.3e-23 80.1 0.1 4.8 3 2 1 4 4 4 3 Mitochondrial carrier protein DUF4106 PF13388.1 EFX01094.1 - 1 8.2 5.1 1.8 7.4 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Pex14_N PF04695.8 EFX01094.1 - 9.8 6.2 18.1 5.4 7.0 0.5 3.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mito_carr PF00153.22 EFX01095.1 - 5.7e-41 138.1 5.0 7.7e-16 57.5 0.3 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein NAD_binding_6 PF08030.7 EFX01095.1 - 9.7e-32 110.0 0.0 2.3e-31 108.7 0.0 1.7 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EFX01095.1 - 1.4e-21 76.3 0.0 3.7e-21 74.9 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 EFX01095.1 - 5.3e-15 55.6 11.2 5.3e-15 55.6 7.8 2.7 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EFX01095.1 - 0.00038 20.5 0.0 0.00082 19.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Talin_middle PF09141.5 EFX01095.1 - 0.056 13.1 0.8 0.12 12.0 0.5 1.5 1 0 0 1 1 1 0 Talin, middle domain HhH-GPD PF00730.20 EFX01096.1 - 7.7e-14 51.8 0.0 1.3e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EFX01096.1 - 4.3e-07 29.2 0.0 1.8e-06 27.2 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif Dicty_REP PF05086.7 EFX01096.1 - 0.1 10.3 0.7 0.13 9.9 0.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Flavokinase PF01687.12 EFX01097.1 - 9.1e-36 122.4 0.0 1.1e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase AA_permease PF00324.16 EFX01098.1 - 1.1e-98 330.6 42.8 1.3e-98 330.4 29.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX01098.1 - 6.1e-21 74.4 44.5 1e-20 73.7 30.8 1.3 1 1 0 1 1 1 1 Amino acid permease NUDIX PF00293.23 EFX01099.1 - 5e-07 29.4 0.0 2.1e-06 27.4 0.0 2.1 1 1 0 1 1 1 1 NUDIX domain MFS_1 PF07690.11 EFX01100.1 - 1.1e-40 139.5 49.7 4.6e-40 137.4 25.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Snf7 PF03357.16 EFX01101.1 - 4.6e-33 114.0 21.1 4.6e-33 114.0 14.6 2.0 1 1 1 2 2 2 1 Snf7 Bcr-Abl_Oligo PF09036.5 EFX01101.1 - 0.0065 16.3 1.4 0.03 14.2 0.2 2.4 2 1 0 2 2 2 1 Bcr-Abl oncoprotein oligomerisation domain OAR PF03826.12 EFX01101.1 - 0.086 12.3 2.0 0.15 11.6 1.4 1.4 1 0 0 1 1 1 0 OAR domain AAA_13 PF13166.1 EFX01101.1 - 0.36 9.2 11.7 0.52 8.7 8.1 1.2 1 0 0 1 1 1 0 AAA domain DUF3138 PF11336.3 EFX01101.1 - 0.4 8.8 11.7 1.3 7.0 7.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) Syntaxin-6_N PF09177.6 EFX01101.1 - 0.65 10.4 7.7 0.33 11.3 3.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal MutS_III PF05192.13 EFX01101.1 - 1.3 8.7 5.6 1.8 8.3 3.9 1.3 1 0 0 1 1 1 0 MutS domain III Fmp27_WPPW PF10359.4 EFX01101.1 - 2.8 6.2 10.5 4.2 5.6 7.3 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Dfp1_Him1_M PF08630.5 EFX01102.1 - 4.6e-39 133.0 0.4 1.5e-38 131.4 0.0 2.1 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.7 EFX01102.1 - 4.7e-24 83.7 1.3 1.1e-23 82.6 0.9 1.7 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.21 EFX01102.1 - 0.01 15.9 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EFX01102.1 - 0.038 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain Arm PF00514.18 EFX01103.1 - 6.2e-94 305.0 15.7 6.2e-14 51.2 0.1 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EFX01103.1 - 4.2e-25 87.8 0.2 1.6e-10 41.1 0.0 5.9 1 1 4 5 5 5 5 HEAT repeats IBB PF01749.15 EFX01103.1 - 3e-23 81.7 1.9 5.2e-23 81.0 1.3 1.4 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.1 EFX01103.1 - 1.1e-21 76.6 11.9 1e-09 38.5 0.0 6.4 5 1 2 7 7 7 4 HEAT-like repeat HEAT PF02985.17 EFX01103.1 - 1.3e-20 71.5 1.1 1.2e-06 28.0 0.0 7.2 8 0 0 8 8 8 4 HEAT repeat Arm_2 PF04826.8 EFX01103.1 - 1.7e-11 43.7 0.0 0.0057 15.7 0.0 4.1 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.15 EFX01103.1 - 1.9e-06 26.4 0.0 0.00032 19.1 0.0 2.9 1 1 1 3 3 3 1 Adaptin N terminal region V-ATPase_H_C PF11698.3 EFX01103.1 - 9.4e-05 22.3 0.0 1.5 8.7 0.0 4.6 2 1 2 5 5 5 2 V-ATPase subunit H HEAT_PBS PF03130.11 EFX01103.1 - 0.00021 21.4 0.1 0.66 10.6 0.0 4.6 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Proteasom_PSMB PF10508.4 EFX01103.1 - 0.0007 17.9 1.1 0.041 12.1 0.1 3.0 3 1 1 4 4 4 2 Proteasome non-ATPase 26S subunit Glycos_trans_3N PF02885.12 EFX01103.1 - 0.052 13.1 0.0 18 5.0 0.0 3.4 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain TrbC PF04956.8 EFX01104.1 - 0.069 13.1 2.6 6.2 6.8 0.7 2.3 1 1 1 2 2 2 0 TrbC/VIRB2 family WD40 PF00400.27 EFX01105.1 - 2.5e-13 49.3 9.4 6.5e-08 32.1 1.1 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat Ribosomal_L37ae PF01780.14 EFX01105.1 - 0.0058 16.4 1.9 0.023 14.5 1.3 2.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family OrfB_Zn_ribbon PF07282.6 EFX01105.1 - 5.4 6.7 7.3 0.91 9.2 0.6 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain WD40 PF00400.27 EFX01106.1 - 1.1e-12 47.3 1.2 0.83 9.6 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Kin17_mid PF10357.4 EFX01107.1 - 1.3e-48 163.8 0.5 1.3e-48 163.8 0.3 2.1 1 1 1 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 EFX01107.1 - 4.9e-05 23.3 0.3 4.9e-05 23.3 0.2 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX01107.1 - 0.00083 19.4 0.7 0.002 18.2 0.5 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EFX01107.1 - 0.02 15.0 1.8 0.051 13.7 0.1 2.2 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PLATZ PF04640.9 EFX01107.1 - 0.14 12.4 0.2 0.59 10.3 0.1 2.0 2 0 0 2 2 2 0 PLATZ transcription factor DUF3449 PF11931.3 EFX01107.1 - 2.6 7.5 8.6 7 6.0 2.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Autophagy_act_C PF03987.10 EFX01109.1 - 3.8e-11 42.9 0.0 8.5e-11 41.8 0.0 1.6 1 1 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Peptidase_M1 PF01433.15 EFX01110.1 - 1.5e-50 172.4 0.0 3.4e-48 164.6 0.0 2.1 2 0 0 2 2 2 2 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 EFX01110.1 - 8.9e-40 135.5 0.0 1.8e-39 134.6 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 EFX01110.1 - 8.3e-19 67.8 0.6 1.5e-18 67.0 0.2 1.7 2 0 0 2 2 2 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 EFX01110.1 - 0.3 11.0 2.2 1.7 8.6 1.5 2.1 1 1 0 1 1 1 0 M61 glycyl aminopeptidase DUF3632 PF12311.3 EFX01112.1 - 0.00096 19.0 0.1 0.002 17.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3632) Pkinase PF00069.20 EFX01113.1 - 3e-16 59.3 0.0 4.5e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01113.1 - 2.1e-06 27.0 0.0 4.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_18 PF13238.1 EFX01114.1 - 1.9e-23 83.1 0.0 2.8e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX01114.1 - 4.3e-12 46.9 0.1 7e-12 46.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX01114.1 - 6.7e-05 22.5 0.3 0.00027 20.6 0.1 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 EFX01114.1 - 8.9e-05 22.4 0.1 0.0007 19.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFX01114.1 - 0.00012 22.2 0.0 0.00065 19.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EFX01114.1 - 0.0004 20.2 0.3 0.1 12.4 0.2 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EFX01114.1 - 0.00061 19.8 0.1 0.0012 18.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain Thymidylate_kin PF02223.12 EFX01114.1 - 0.0024 17.2 0.1 1.8 7.9 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase T2SE PF00437.15 EFX01114.1 - 0.0026 16.6 0.1 0.0051 15.7 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.10 EFX01114.1 - 0.0037 16.9 0.1 0.0067 16.1 0.1 1.4 1 0 0 1 1 1 1 NTPase AAA_22 PF13401.1 EFX01114.1 - 0.01 15.9 0.1 0.037 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 EFX01114.1 - 0.013 15.0 0.1 0.026 13.9 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF927 PF06048.6 EFX01114.1 - 0.02 14.1 0.0 2.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF927) DUF2075 PF09848.4 EFX01114.1 - 0.028 13.4 0.1 0.27 10.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ADK PF00406.17 EFX01114.1 - 0.031 14.1 0.0 0.3 10.9 0.0 2.0 2 0 0 2 2 2 0 Adenylate kinase IstB_IS21 PF01695.12 EFX01114.1 - 0.032 13.6 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.1 EFX01114.1 - 0.064 12.8 0.6 0.23 11.0 0.3 1.9 1 1 1 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EFX01114.1 - 0.08 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 EFX01114.1 - 0.098 12.9 0.0 0.19 12.0 0.0 1.5 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EFX01114.1 - 0.1 12.3 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SMC_N PF02463.14 EFX01114.1 - 0.12 11.5 0.0 0.49 9.5 0.0 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Pkinase PF00069.20 EFX01115.1 - 4e-70 235.9 0.0 7.9e-70 234.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01115.1 - 4.1e-49 166.9 0.0 7.2e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX01115.1 - 0.0013 17.7 0.0 0.0055 15.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like DUF2321 PF10083.4 EFX01115.1 - 0.027 13.9 0.2 0.062 12.7 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Ric8 PF10165.4 EFX01115.1 - 0.028 13.2 0.8 0.25 10.0 0.4 2.2 1 1 0 1 1 1 0 Guanine nucleotide exchange factor synembryn PAP2 PF01569.16 EFX01116.1 - 6.7e-19 67.8 0.1 5.3e-18 64.9 0.0 2.2 2 1 0 2 2 2 1 PAP2 superfamily TPPK_C PF12555.3 EFX01116.1 - 0.66 9.7 3.8 13 5.5 0.0 3.2 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal Sec10 PF07393.6 EFX01117.1 - 7.6e-148 493.7 0.0 7.1e-106 355.0 0.0 2.3 2 1 0 2 2 2 2 Exocyst complex component Sec10 F-box-like PF12937.2 EFX01117.1 - 2.6e-06 27.0 0.9 5.7e-06 25.9 0.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EFX01117.1 - 2.9e-06 26.7 0.2 5.5e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 F-box domain Xan_ur_permease PF00860.15 EFX01118.1 - 8.2e-10 37.7 6.2 8.2e-10 37.7 4.3 1.9 1 1 1 2 2 2 1 Permease family Sulfate_transp PF00916.15 EFX01118.1 - 0.089 11.7 7.3 0.02 13.9 2.4 1.8 2 1 0 2 2 2 0 Sulfate transporter family 2TM PF13239.1 EFX01118.1 - 1.2 9.2 0.0 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 2TM domain Ank PF00023.25 EFX01119.1 - 4.7e-17 60.8 0.6 3.2e-11 42.4 0.4 2.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 EFX01119.1 - 1.1e-16 60.8 0.9 3.7e-10 40.0 0.1 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX01119.1 - 3.2e-16 59.4 0.0 5.4e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFX01119.1 - 6.1e-16 58.0 1.4 2.3e-11 43.5 0.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX01119.1 - 5.4e-11 41.6 0.0 3.1e-08 33.0 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat ArfGap PF01412.13 EFX01120.1 - 4e-41 139.4 0.4 5.9e-41 138.9 0.3 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Acyl-CoA_dh_1 PF00441.19 EFX01121.1 - 3.4e-13 49.9 0.5 3.3e-12 46.7 0.2 2.7 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFX01121.1 - 3.1e-07 29.7 1.8 1.3e-06 27.8 1.3 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Glyco_transf_41 PF13844.1 EFX01123.1 - 2.4e-74 250.0 3.4 3.1e-46 157.3 0.0 4.3 3 2 2 5 5 5 3 Glycosyl transferase family 41 TPR_11 PF13414.1 EFX01123.1 - 1.8e-19 69.0 2.8 3.7e-06 26.4 0.0 5.1 4 1 1 5 5 5 3 TPR repeat TPR_1 PF00515.23 EFX01123.1 - 3.4e-17 61.2 2.4 0.016 14.8 0.0 6.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.12 EFX01123.1 - 9.4e-15 53.2 3.6 0.0026 17.5 0.0 6.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.1 EFX01123.1 - 1e-12 47.8 3.7 0.00018 21.3 0.1 5.0 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX01123.1 - 3e-09 36.7 0.6 0.15 12.7 0.0 5.9 4 2 2 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFX01123.1 - 1.9e-08 33.4 0.0 0.012 15.2 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 EFX01123.1 - 4.3e-08 32.7 0.0 0.15 12.2 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX01123.1 - 6.3e-07 29.8 5.0 0.15 12.8 0.0 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 EFX01123.1 - 0.00013 21.7 11.2 2.2 8.3 0.0 6.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFX01123.1 - 0.00021 20.8 0.2 0.25 11.2 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX01123.1 - 0.0055 17.0 3.9 0.12 12.7 0.0 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX01123.1 - 0.02 15.3 0.1 17 6.1 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Rho_N PF07498.7 EFX01124.1 - 2.8e-05 23.7 0.3 5.6e-05 22.8 0.2 1.5 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain Glyco_hydro_76 PF03663.9 EFX01125.1 - 5.9e-136 453.6 20.2 8e-136 453.2 14.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 TFIIA PF03153.8 EFX01127.1 - 0.2 11.4 0.9 0.26 11.1 0.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.7 EFX01127.1 - 3.5 6.1 13.2 3.9 6.0 9.1 1.2 1 0 0 1 1 1 0 Hamartin protein Zn_clus PF00172.13 EFX01128.1 - 9.1e-05 22.2 10.9 0.00019 21.2 7.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX01128.1 - 0.0011 17.9 0.8 0.0011 17.9 0.6 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Ank_5 PF13857.1 EFX01129.1 - 1.1e-38 130.3 7.0 2.9e-10 40.0 0.0 4.8 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX01129.1 - 7.8e-38 128.7 0.9 2.1e-15 56.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01129.1 - 1.5e-35 119.2 2.3 9.7e-07 28.2 0.0 5.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 EFX01129.1 - 3.3e-35 119.8 9.6 8.5e-09 35.6 0.2 5.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX01129.1 - 3.5e-28 94.8 0.2 0.00074 19.5 0.0 6.1 6 0 0 6 6 6 5 Ankyrin repeat DUF4637 PF15470.1 EFX01131.1 - 1.2 8.7 6.6 1.2 8.7 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF781 PF05612.7 EFX01132.1 - 0.51 8.9 0.0 0.82 8.2 0.0 1.2 1 0 0 1 1 1 0 Mouse protein of unknown function (DUF781) p450 PF00067.17 EFX01133.1 - 1.7e-46 158.6 0.0 1.8e-44 152.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 HhH-GPD PF00730.20 EFX01134.1 - 2.3e-15 56.8 0.0 5.2e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein SRP72 PF08492.7 EFX01135.1 - 3e-10 40.2 1.8 3e-10 40.2 1.2 1.8 2 0 0 2 2 2 1 SRP72 RNA-binding domain SPO22 PF08631.5 EFX01135.1 - 0.044 12.8 0.1 0.19 10.7 0.0 2.0 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_16 PF13432.1 EFX01135.1 - 0.19 12.4 0.2 0.19 12.4 0.1 7.7 6 2 2 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFX01135.1 - 1.1 9.1 27.8 0.12 12.2 1.1 5.5 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFX01135.1 - 4.9 7.3 18.3 4.2 7.5 0.2 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat adh_short PF00106.20 EFX01136.1 - 0.0019 18.1 1.2 0.029 14.2 1.0 2.6 2 1 0 2 2 2 1 short chain dehydrogenase MSC PF09402.5 EFX01137.1 - 6.7e-89 297.8 0.0 9.5e-89 297.3 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.2 EFX01137.1 - 8.9e-14 50.7 0.0 1.5e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 HeH/LEM domain Thymopoietin PF08198.6 EFX01137.1 - 0.03 13.8 0.0 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 Thymopoietin protein DUF3350 PF11830.3 EFX01137.1 - 1 9.4 5.0 15 5.7 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3350) MarR_2 PF12802.2 EFX01138.1 - 0.052 13.2 0.5 0.14 11.8 0.3 1.7 1 0 0 1 1 1 0 MarR family AA_permease_2 PF13520.1 EFX01139.1 - 3.3e-86 289.4 40.5 3.9e-86 289.2 28.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX01139.1 - 5.4e-16 57.9 37.6 1e-15 57.0 26.1 1.4 1 1 0 1 1 1 1 Amino acid permease Sec39 PF08314.6 EFX01140.1 - 1.6e-179 598.2 0.0 2e-179 597.9 0.0 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 YtxH PF12732.2 EFX01141.1 - 0.15 12.4 2.5 0.39 11.1 1.7 1.7 1 0 0 1 1 1 0 YtxH-like protein Ribosomal_S9 PF00380.14 EFX01142.1 - 1.7e-36 125.1 1.0 2.8e-36 124.4 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Synaptobrevin PF00957.16 EFX01143.1 - 0.0076 15.8 0.5 0.036 13.6 0.2 1.9 1 1 1 2 2 2 1 Synaptobrevin SNARE PF05739.14 EFX01143.1 - 0.019 14.6 0.0 0.03 13.9 0.0 1.3 1 1 0 1 1 1 0 SNARE domain DUF4349 PF14257.1 EFX01143.1 - 0.072 12.3 0.1 0.083 12.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) MFS_1 PF07690.11 EFX01144.1 - 2.9e-23 82.1 38.1 2.9e-23 82.1 26.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cu-oxidase_3 PF07732.10 EFX01145.1 - 2.5e-39 133.6 2.2 1.4e-37 128.0 0.1 3.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX01145.1 - 3.1e-32 110.9 6.2 1.2e-29 102.5 1.0 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EFX01145.1 - 2.2e-14 53.6 0.0 1.3e-13 51.1 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase Zn_clus PF00172.13 EFX01147.1 - 5.4e-07 29.4 6.5 5.4e-07 29.4 4.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX01147.1 - 0.0014 17.5 0.0 0.0026 16.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dickkopf_N PF04706.7 EFX01147.1 - 1.6 8.9 10.2 3.7 7.7 7.1 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Fapy_DNA_glyco PF01149.19 EFX01148.1 - 1.6e-23 83.2 0.1 2.9e-23 82.4 0.0 1.5 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.9 EFX01148.1 - 2.4e-20 72.0 0.0 4.6e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Alpha-L-AF_C PF06964.7 EFX01149.1 - 6.6e-44 149.7 0.1 1.6e-43 148.5 0.0 1.7 2 0 0 2 2 2 1 Alpha-L-arabinofuranosidase C-terminus zf-RING_4 PF14570.1 EFX01150.1 - 7.2e-19 67.1 12.8 1.3e-18 66.3 8.9 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.17 EFX01150.1 - 2e-09 36.9 0.0 6.4e-09 35.3 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01150.1 - 1e-07 31.8 0.0 6.6e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 EFX01150.1 - 4.1e-06 26.3 7.6 7.4e-06 25.5 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_5 PF13893.1 EFX01150.1 - 1.7e-05 24.5 0.0 3.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.7 EFX01150.1 - 0.00019 20.7 4.1 0.00019 20.7 2.8 4.1 3 1 0 3 3 2 1 Rtf2 RING-finger SET_assoc PF11767.3 EFX01150.1 - 0.008 15.4 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Baculo_IE-1 PF05290.6 EFX01150.1 - 0.028 14.1 5.3 0.055 13.2 3.7 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Nup35_RRM_2 PF14605.1 EFX01150.1 - 0.073 12.8 0.0 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-UDP PF14569.1 EFX01150.1 - 0.38 10.5 5.2 0.33 10.7 2.2 1.9 2 0 0 2 2 1 0 Zinc-binding RING-finger zf-C3HC4_2 PF13923.1 EFX01150.1 - 0.85 9.6 11.6 1.7 8.7 8.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.11 EFX01150.1 - 3.3 7.6 17.7 0.014 15.2 3.4 2.7 1 1 1 2 2 2 0 FYVE-type zinc finger MFS_1 PF07690.11 EFX01151.1 - 8.1e-31 107.0 31.3 8.1e-31 107.0 21.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily HLH PF00010.21 EFX01152.1 - 2.2e-09 36.8 0.1 5.1e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain BORG_CEP PF14957.1 EFX01152.1 - 1.1 10.1 7.5 1.8 9.4 1.5 2.5 2 0 0 2 2 2 0 Cdc42 effector TMF_TATA_bd PF12325.3 EFX01153.1 - 9.5e-38 128.6 8.0 9.5e-38 128.6 5.5 6.7 3 2 2 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 EFX01153.1 - 7.3e-16 57.7 11.2 7.3e-16 57.7 7.8 9.5 3 2 5 9 9 9 1 TATA element modulatory factor 1 DNA binding Saccharop_dh PF03435.13 EFX01154.1 - 9.5e-129 429.7 0.0 1.1e-128 429.5 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 EFX01154.1 - 4.3e-06 26.8 0.3 8.5e-06 25.9 0.2 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 EFX01154.1 - 0.00042 20.3 0.6 0.0007 19.6 0.4 1.3 1 0 0 1 1 1 1 NADH(P)-binding IlvN PF07991.7 EFX01154.1 - 0.0012 18.2 0.8 0.011 15.1 0.2 2.6 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_3 PF03447.11 EFX01154.1 - 0.013 15.8 0.3 0.023 15.0 0.2 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.17 EFX01154.1 - 0.024 15.1 0.1 0.047 14.1 0.1 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold CN_hydrolase PF00795.17 EFX01156.1 - 1.5e-24 86.3 0.0 2.4e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 EFX01156.1 - 4.7e-19 68.2 0.0 1.6e-17 63.2 0.0 2.7 1 1 0 1 1 1 1 NAD synthase Hexapep PF00132.19 EFX01157.1 - 1.3e-11 43.4 2.8 0.00042 19.7 0.5 3.7 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFX01157.1 - 0.00029 20.3 6.5 0.07 12.7 1.6 3.4 2 1 2 4 4 4 4 Hexapeptide repeat of succinyl-transferase Ten1 PF12658.2 EFX01158.1 - 3e-21 75.4 0.0 3.5e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Cytochrom_B558a PF05038.8 EFX01158.1 - 0.0084 15.7 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome Cytochrome b558 alpha-subunit DASH_Duo1 PF08651.5 EFX01159.1 - 3.4e-26 90.6 0.5 4.9e-26 90.1 0.4 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF572 PF04502.8 EFX01159.1 - 0.017 14.3 0.7 0.021 14.0 0.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF745 PF05335.8 EFX01159.1 - 0.042 13.3 5.2 0.07 12.6 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF2422 PF10337.4 EFX01159.1 - 0.2 10.3 0.4 0.26 10.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) DUF4611 PF15387.1 EFX01159.1 - 0.24 11.5 3.4 1.9 8.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) NIF PF03031.13 EFX01160.1 - 9e-19 67.6 0.0 1.2e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2063 PF09836.4 EFX01160.1 - 0.013 15.4 0.3 2.1 8.3 0.0 2.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2063) DNA_primase_lrg PF04104.9 EFX01161.1 - 1.1e-81 273.9 0.0 1.6e-81 273.3 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Motile_Sperm PF00635.21 EFX01162.1 - 8.6e-24 83.2 0.1 2.4e-23 81.8 0.1 1.7 1 1 1 2 2 2 1 MSP (Major sperm protein) domain Cyclin_N PF00134.18 EFX01163.1 - 3.6e-43 146.1 0.1 7.4e-43 145.1 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFX01163.1 - 1.6e-30 105.4 0.1 4.3e-30 104.0 0.0 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_L2_C PF03947.13 EFX01164.1 - 2.9e-45 153.2 3.0 6e-32 110.1 1.9 2.5 2 0 0 2 2 2 2 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EFX01164.1 - 6.4e-26 90.1 0.1 1.2e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain PEP-utilizers PF00391.18 EFX01164.1 - 0.048 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain p450 PF00067.17 EFX01165.1 - 1.5e-38 132.4 0.0 1.9e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_2 PF13347.1 EFX01167.1 - 3.6e-09 35.5 13.4 3.6e-09 35.5 9.3 2.7 3 0 0 3 3 3 1 MFS/sugar transport protein Ribosomal_L11_N PF03946.9 EFX01169.1 - 3.6e-18 64.7 0.1 5.7e-18 64.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EFX01169.1 - 1.1e-10 41.5 0.0 1.8e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain IF2_N PF04760.10 EFX01169.1 - 0.019 14.6 0.2 0.8 9.4 0.0 3.0 1 1 1 2 2 2 0 Translation initiation factor IF-2, N-terminal region zf-RING_2 PF13639.1 EFX01170.1 - 3.9e-11 42.5 5.4 7.5e-11 41.6 3.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFX01170.1 - 9e-10 38.5 4.0 1.6e-09 37.6 2.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EFX01170.1 - 8e-07 28.6 7.3 9.4e-06 25.2 5.3 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX01170.1 - 1.9e-06 27.4 3.1 3.3e-06 26.7 2.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFX01170.1 - 0.00012 21.6 4.3 0.00021 20.8 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX01170.1 - 0.00096 19.1 6.7 0.0039 17.1 4.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFX01170.1 - 0.0032 17.1 2.7 0.0078 15.9 1.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-Apc11 PF12861.2 EFX01170.1 - 0.018 14.8 3.9 0.051 13.4 2.7 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 EFX01170.1 - 0.035 13.9 1.4 0.072 12.9 1.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 EFX01170.1 - 0.15 11.6 3.1 0.41 10.2 2.1 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 EFX01170.1 - 0.29 10.7 2.0 0.57 9.7 1.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.3 EFX01170.1 - 1.5 8.8 4.1 9.3 6.2 2.9 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Ion_trans_2 PF07885.11 EFX01171.1 - 3.5e-31 106.7 25.5 4.4e-18 64.7 3.6 3.1 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.26 EFX01171.1 - 2.9 7.0 20.5 0.061 12.5 1.4 3.2 2 1 1 3 3 3 0 Ion transport protein Ham1p_like PF01725.11 EFX01172.1 - 7.7e-52 175.4 0.0 9.1e-52 175.1 0.0 1.0 1 0 0 1 1 1 1 Ham1 family p450 PF00067.17 EFX01173.1 - 6.4e-49 166.7 0.0 9.7e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L4 PF00573.17 EFX01174.1 - 1.6e-36 125.5 0.1 2.1e-36 125.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 EFX01174.1 - 1.2e-15 57.1 1.9 2.9e-15 55.9 1.3 1.6 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain PIF1 PF05970.9 EFX01174.1 - 0.049 12.5 0.1 0.071 12.0 0.1 1.1 1 0 0 1 1 1 0 PIF1-like helicase CAS_CSE1 PF03378.10 EFX01175.1 - 1.2e-167 557.6 0.0 2.4e-167 556.6 0.0 1.5 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.5 EFX01175.1 - 3.9e-148 492.9 0.5 5.5e-148 492.4 0.4 1.2 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.14 EFX01175.1 - 4.1e-13 49.0 0.0 1.3e-12 47.4 0.0 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFX01175.1 - 2.5e-05 24.2 0.5 0.0053 16.6 0.0 4.2 3 2 1 4 4 4 1 Exportin 1-like protein DUF3295 PF11702.3 EFX01176.1 - 1.1e-119 400.7 32.5 8e-98 328.6 16.7 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3295) DUF1752 PF08550.5 EFX01176.1 - 1.7e-06 27.4 3.3 3.7e-06 26.3 2.3 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Ebola_NP PF05505.7 EFX01176.1 - 0.53 8.2 8.3 0.71 7.8 5.8 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein Pribosyltran PF00156.22 EFX01177.1 - 8.9e-18 64.2 0.0 1.4e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EFX01177.1 - 0.00032 19.9 0.0 0.00042 19.5 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase TauD PF02668.11 EFX01178.1 - 8.5e-48 163.2 0.6 1.5e-47 162.4 0.4 1.4 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF1399 PF07173.7 EFX01178.1 - 7e-21 74.9 1.1 1.6e-16 60.8 0.0 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF1399) APS_kinase PF01583.15 EFX01179.1 - 6.8e-71 236.9 0.0 3.5e-70 234.6 0.0 2.1 2 0 0 2 2 2 1 Adenylylsulphate kinase MutS_V PF00488.16 EFX01179.1 - 2.4e-53 180.9 2.0 2.7e-53 180.8 0.0 2.2 3 1 0 3 3 2 1 MutS domain V AAA_33 PF13671.1 EFX01179.1 - 1.9e-09 37.5 3.4 2.7e-06 27.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 EFX01179.1 - 4.5e-08 33.9 0.3 3.8e-06 27.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFX01179.1 - 3.7e-05 23.1 0.0 0.37 10.3 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain KTI12 PF08433.5 EFX01179.1 - 0.00014 21.1 1.4 0.0023 17.1 0.0 2.6 3 0 0 3 3 3 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 EFX01179.1 - 0.00027 21.2 0.0 0.0011 19.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EFX01179.1 - 0.013 15.6 0.0 5.7 7.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.1 EFX01179.1 - 0.014 15.3 0.1 2.3 8.1 0.1 2.8 2 1 0 2 2 2 0 AAA ATPase domain Motile_Sperm PF00635.21 EFX01179.1 - 0.033 13.8 2.1 0.068 12.8 1.5 1.5 1 0 0 1 1 1 0 MSP (Major sperm protein) domain AAA_14 PF13173.1 EFX01179.1 - 0.036 13.9 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain G-7-MTase PF12803.2 EFX01179.1 - 0.82 8.7 4.1 1.5 7.9 2.8 1.3 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Macoilin PF09726.4 EFX01179.1 - 2.4 6.3 17.8 3.4 5.8 12.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Phostensin_N PF13916.1 EFX01180.1 - 0.063 13.2 2.1 0.087 12.8 0.4 2.0 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Calici_MSP PF05752.6 EFX01180.1 - 0.14 11.7 5.5 0.24 10.9 3.8 1.3 1 0 0 1 1 1 0 Calicivirus minor structural protein WXG100 PF06013.7 EFX01181.1 - 0.45 10.5 6.6 0.49 10.4 3.1 1.9 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF883 PF05957.8 EFX01181.1 - 0.47 10.8 7.1 1.1 9.6 2.5 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.2 EFX01181.1 - 0.66 10.3 11.0 1.5e+02 2.8 7.6 2.4 1 1 0 1 1 1 0 YtxH-like protein DivIVA PF05103.8 EFX01181.1 - 0.7 9.9 7.4 0.75 9.8 1.7 2.1 1 1 1 2 2 2 0 DivIVA protein Uds1 PF15456.1 EFX01181.1 - 2.1 8.3 5.0 1.3 9.0 2.1 1.7 1 1 1 2 2 2 0 Up-regulated During Septation FAD_binding_1 PF00667.15 EFX01182.1 - 2.4e-42 144.8 0.0 4.1e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 EFX01182.1 - 3.1e-10 40.5 0.0 1.6e-09 38.2 0.0 2.2 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain FA_desaturase PF00487.19 EFX01183.1 - 1.6e-18 67.0 25.0 1.6e-18 67.0 17.3 1.9 1 1 1 2 2 2 2 Fatty acid desaturase UQ_con PF00179.21 EFX01184.1 - 1.6e-36 124.7 0.0 2e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 EFX01184.1 - 0.11 12.2 0.1 0.19 11.4 0.1 1.4 1 1 0 1 1 1 0 UEV domain PHD PF00628.24 EFX01185.1 - 3.4e-08 33.0 9.4 6.9e-08 32.0 6.5 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 EFX01185.1 - 0.0026 17.0 5.7 0.0051 16.0 3.9 1.5 1 0 0 1 1 1 1 PHD-finger Glyco_hydro_28 PF00295.12 EFX01186.1 - 1.2e-46 159.1 0.8 2.7e-46 158.0 0.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 End_N_terminal PF12218.3 EFX01186.1 - 0.0096 15.3 0.0 0.025 14.0 0.0 1.7 1 0 0 1 1 1 1 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.1 EFX01186.1 - 1.2 8.8 9.1 12 5.6 6.3 2.3 1 1 0 1 1 1 0 Right handed beta helix region Ribonuc_L-PSP PF01042.16 EFX01187.1 - 9.1e-19 67.4 0.1 1.1e-18 67.1 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP MMR_HSR1_C PF08438.5 EFX01187.1 - 0.1 12.8 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 GTPase of unknown function C-terminal DUF1761 PF08570.5 EFX01188.1 - 1.3e-21 76.9 1.0 1.5e-21 76.7 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Glucosamine_iso PF01182.15 EFX01189.1 - 1.4e-22 80.3 0.0 2.3e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase FTR1 PF03239.9 EFX01190.1 - 2.9e-80 269.4 9.4 3.4e-80 269.2 6.5 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Toxin_4 PF00706.12 EFX01190.1 - 2.5 8.3 6.4 11 6.3 4.4 2.1 1 1 0 1 1 1 0 Anenome neurotoxin Abhydrolase_6 PF12697.2 EFX01193.1 - 2.1e-17 63.7 8.9 4.5e-17 62.7 6.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX01193.1 - 1.5e-16 60.7 1.7 1.4e-15 57.5 1.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX01193.1 - 7.6e-08 32.2 0.1 9e-06 25.4 0.1 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EFX01193.1 - 0.002 17.6 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 EFX01193.1 - 0.032 13.6 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.5 EFX01193.1 - 0.084 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein VHS PF00790.14 EFX01194.1 - 9.3e-26 90.1 0.0 1.9e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.9 EFX01194.1 - 3.6e-07 30.1 0.9 9.1e-07 28.7 0.6 1.7 1 0 0 1 1 1 1 GAT domain SPRY PF00622.23 EFX01195.1 - 6.8e-18 64.9 0.0 1.1e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 SPRY domain HAD_2 PF13419.1 EFX01196.1 - 4.1e-14 53.2 0.0 6e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX01196.1 - 5.5e-07 29.2 0.0 1.8e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 EFX01196.1 - 5.2e-05 23.7 0.0 0.00049 20.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pterin_bind PF00809.17 EFX01196.1 - 0.062 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Pterin binding enzyme Hydrolase_6 PF13344.1 EFX01196.1 - 0.16 11.9 0.0 3.1 7.7 0.0 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF2984 PF11203.3 EFX01196.1 - 0.28 11.3 1.8 16 5.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2984) OB_NTP_bind PF07717.11 EFX01197.1 - 8.7e-16 57.7 0.0 1.7e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EFX01197.1 - 3.3e-13 49.2 0.2 8.9e-13 47.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 EFX01197.1 - 1.2e-12 47.6 0.5 4.6e-12 45.8 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.24 EFX01197.1 - 1.2e-05 24.8 0.0 4.1e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.17 EFX01197.1 - 0.00093 19.0 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 RWD domain AAA_29 PF13555.1 EFX01197.1 - 0.0039 16.6 0.0 0.0092 15.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SE PF00437.15 EFX01197.1 - 0.005 15.7 0.0 0.012 14.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 EFX01197.1 - 0.016 15.3 1.2 0.12 12.4 0.8 2.5 1 1 0 1 1 1 0 AAA domain DND1_DSRM PF14709.1 EFX01197.1 - 0.024 14.9 0.0 0.069 13.4 0.0 1.8 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 UBA PF00627.26 EFX01197.1 - 0.083 12.7 0.2 5.4 7.0 0.1 2.7 2 0 0 2 2 2 0 UBA/TS-N domain KaiC PF06745.8 EFX01197.1 - 0.089 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.1 EFX01197.1 - 0.34 11.1 0.1 0.75 10.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain PCI_Csn8 PF10075.4 EFX01198.1 - 6.2e-38 129.7 0.0 8.7e-38 129.3 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 EFX01198.1 - 1.7e-22 79.9 0.1 2.2e-22 79.6 0.1 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Polyketide_cyc2 PF10604.4 EFX01199.1 - 0.0046 17.1 0.2 0.012 15.8 0.2 1.7 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Phage_lysis PF03245.8 EFX01199.1 - 0.38 10.7 6.1 0.15 12.0 2.0 2.0 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Peptidase_C78 PF07910.8 EFX01200.1 - 3.7e-61 206.0 0.0 5.1e-61 205.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 MIP-T3 PF10243.4 EFX01200.1 - 8.8 4.6 22.0 12 4.1 15.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ion_trans PF00520.26 EFX01203.1 - 3.1e-95 317.1 79.9 8.4e-31 106.7 5.2 5.1 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.27 EFX01203.1 - 0.0058 15.8 0.0 0.016 14.4 0.0 1.9 1 0 0 1 1 1 1 EF hand Glyco_hydro_47 PF01532.15 EFX01204.1 - 1.6e-140 468.7 0.0 5e-140 467.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 SAP PF02037.22 EFX01205.1 - 1.6e-14 52.9 0.1 2.7e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 SAP domain HeH PF12949.2 EFX01205.1 - 0.0068 15.9 0.1 0.015 14.8 0.1 1.6 1 0 0 1 1 1 1 HeH/LEM domain Armet PF10208.4 EFX01205.1 - 0.11 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding Spt4 PF06093.8 EFX01206.1 - 1.8e-32 111.0 0.1 2.2e-32 110.7 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.6 EFX01206.1 - 0.022 14.5 0.7 0.082 12.7 0.1 2.1 1 1 1 2 2 2 0 Coronavirus gene 5 protein TBCC PF07986.7 EFX01206.1 - 0.13 11.6 0.3 0.18 11.2 0.2 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor C Fungal_trans PF04082.13 EFX01207.1 - 5.3e-25 87.7 0.0 1.1e-24 86.7 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01207.1 - 0.00039 20.2 5.6 0.00061 19.6 3.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PEMT PF04191.8 EFX01209.1 - 9.1e-30 102.8 2.8 9.1e-30 102.8 1.9 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase Ceramidase PF05875.7 EFX01210.1 - 3.3e-93 311.6 15.8 3.8e-93 311.4 10.9 1.0 1 0 0 1 1 1 1 Ceramidase TMEM191C PF15194.1 EFX01210.1 - 0.14 12.0 0.1 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 TMEM191C family Oxidored_q2 PF00420.19 EFX01210.1 - 3.7 7.2 10.9 0.41 10.2 3.7 2.3 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Mod_r PF07200.8 EFX01211.1 - 4.2e-10 39.7 1.5 4.3e-09 36.4 0.1 2.0 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein CobN-Mg_chel PF02514.11 EFX01211.1 - 0.04 11.3 0.1 0.049 11.0 0.1 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase Gal4_dimer PF03902.8 EFX01211.1 - 0.31 11.0 1.7 20 5.1 0.0 2.3 2 0 0 2 2 2 0 Gal4-like dimerisation domain FUSC PF04632.7 EFX01211.1 - 0.91 7.8 12.9 1.1 7.5 9.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Mob1_phocein PF03637.12 EFX01212.1 - 3.6e-36 124.4 1.8 1.2e-18 67.4 0.0 2.1 2 0 0 2 2 2 2 Mob1/phocein family bZIP_2 PF07716.10 EFX01213.1 - 0.014 15.1 10.2 0.014 15.1 7.1 2.5 3 0 0 3 3 3 0 Basic region leucine zipper DUF605 PF04652.11 EFX01213.1 - 5.1 6.3 17.2 3.9 6.7 11.4 1.3 1 1 0 1 1 1 0 Vta1 like DUF188 PF02639.9 EFX01213.1 - 5.3 6.5 7.2 16 4.9 2.4 2.4 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 bZIP_1 PF00170.16 EFX01213.1 - 9.5 6.2 25.5 0.051 13.5 6.5 3.3 3 1 1 4 4 4 0 bZIP transcription factor Med11 PF10280.4 EFX01215.1 - 1e-29 102.9 0.0 1.6e-29 102.3 0.0 1.3 1 0 0 1 1 1 1 Mediator complex protein Glyoxalase PF00903.20 EFX01216.1 - 6.3e-40 136.1 0.2 2.5e-19 69.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFX01216.1 - 8.4e-31 106.7 0.1 5.9e-15 55.8 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 EFX01216.1 - 2.9e-17 62.6 0.0 4.3e-07 29.9 0.0 3.7 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 EFX01216.1 - 5.2e-06 26.4 0.0 0.14 12.0 0.0 3.6 2 1 0 3 3 3 2 Glyoxalase-like domain MoaF PF10703.4 EFX01216.1 - 0.02 14.0 0.0 0.28 10.2 0.0 2.0 2 0 0 2 2 2 0 Molybdenum cofactor biosynthesis protein F PulG PF11773.3 EFX01216.1 - 0.068 12.9 0.0 1.6 8.5 0.0 2.2 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin CppA_N PF14506.1 EFX01216.1 - 0.075 12.7 0.0 3 7.5 0.0 2.3 2 0 0 2 2 2 0 CppA N-terminal PRT_C PF08372.5 EFX01216.1 - 0.093 12.2 0.0 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal Shadoo PF14999.1 EFX01217.1 - 4 7.2 14.2 1.3 8.8 1.3 3.0 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective MMgT PF10270.4 EFX01218.1 - 1.4e-32 112.2 0.0 1.7e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 Membrane magnesium transporter Dehydrin PF00257.14 EFX01221.1 - 0.49 10.7 6.0 1.1 9.5 4.2 1.8 1 1 0 1 1 1 0 Dehydrin Atg14 PF10186.4 EFX01222.1 - 3.8e-13 49.0 0.0 5.8e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 EFX01222.1 - 0.0023 17.0 0.2 0.013 14.6 0.0 2.2 3 0 0 3 3 3 1 Autophagy protein Apg6 Snapin_Pallidin PF14712.1 EFX01222.1 - 0.066 13.5 0.4 0.32 11.3 0.1 2.1 2 0 0 2 2 2 0 Snapin/Pallidin Cortex-I_coil PF09304.5 EFX01222.1 - 0.58 10.2 3.7 1.2 9.2 1.5 2.0 1 1 1 2 2 2 0 Cortexillin I, coiled coil GTP_EFTU PF00009.22 EFX01223.1 - 2.5e-45 154.2 0.0 4.1e-45 153.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 EFX01223.1 - 1e-15 57.5 0.8 2e-15 56.6 0.5 1.4 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.12 EFX01223.1 - 1.8e-07 31.2 0.0 5e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFX01223.1 - 1.3e-06 28.4 1.4 3.3e-06 27.1 0.1 2.4 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX01223.1 - 6.3e-06 26.1 0.0 2e-05 24.5 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFX01223.1 - 0.00016 22.1 0.0 0.0079 16.6 0.0 2.5 1 1 0 1 1 1 1 Miro-like protein PGA2 PF07543.7 EFX01224.1 - 8.9e-40 135.7 0.1 1e-39 135.5 0.1 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 YedD PF13987.1 EFX01224.1 - 0.00079 18.9 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 YedD-like protein REV PF00424.13 EFX01224.1 - 0.039 13.8 0.2 0.093 12.6 0.1 1.6 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) STE3 PF02076.10 EFX01224.1 - 0.12 11.4 0.1 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Pheromone A receptor DUF945 PF06097.6 EFX01224.1 - 0.12 11.0 1.2 0.13 11.0 0.8 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) PhyH PF05721.8 EFX01225.1 - 5.7e-51 173.5 0.0 7.3e-51 173.1 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.1 EFX01225.1 - 0.00055 20.4 0.0 0.013 15.9 0.0 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Med5 PF08689.5 EFX01226.1 - 3.9e-200 667.0 0.0 5.3e-200 666.6 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 MOR2-PAG1_C PF14225.1 EFX01226.1 - 0.006 16.3 0.7 0.014 15.1 0.5 1.6 1 0 0 1 1 1 1 Cell morphogenesis C-terminal Mito_carr PF00153.22 EFX01228.1 - 3.4e-73 241.4 0.0 4.3e-25 87.2 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 EFX01228.1 - 2e-12 47.0 1.8 1.2e-06 28.5 0.1 4.1 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 EFX01228.1 - 4.3e-12 44.3 0.0 9.5e-07 27.6 0.0 4.1 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 EFX01228.1 - 9.9e-12 43.7 0.4 2.1e-05 24.0 0.0 5.3 6 0 0 6 6 6 2 EF-hand domain EF-hand_8 PF13833.1 EFX01228.1 - 3.2e-10 39.4 0.1 0.18 11.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 EFX01228.1 - 2.6e-07 29.6 0.3 9.4e-06 24.7 0.0 3.0 3 0 0 3 3 3 1 EF hand WD40 PF00400.27 EFX01229.1 - 5.6e-19 67.2 10.4 3.3e-07 29.9 0.0 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat Rax2 PF12768.2 EFX01229.1 - 0.02 14.1 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Es2 PF09751.4 EFX01230.1 - 8.3e-92 308.7 0.0 1.7e-91 307.7 0.0 1.5 1 0 0 1 1 1 1 Nuclear protein Es2 ABC1 PF03109.11 EFX01230.1 - 3.1e-30 104.5 0.0 6.4e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 ABC1 family ADH_N PF08240.7 EFX01231.1 - 3.9e-05 23.3 0.1 0.00013 21.7 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX01231.1 - 0.0002 20.9 0.4 0.00035 20.1 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Abhydrolase_4 PF08386.5 EFX01232.1 - 6.5e-20 70.9 0.0 1.2e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 EFX01232.1 - 2.8e-17 63.0 0.1 6.9e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX01232.1 - 1.3e-09 38.2 1.3 3.1e-08 33.7 0.8 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX01232.1 - 0.0043 16.8 0.1 0.77 9.4 0.0 2.6 2 1 0 2 2 2 2 Alpha/beta hydrolase family NDT80_PhoG PF05224.7 EFX01233.1 - 5.3e-33 114.5 0.0 5.3e-33 114.5 0.0 2.3 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family PAT1 PF09770.4 EFX01233.1 - 0.00072 17.9 37.4 0.00091 17.6 25.9 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Gti1_Pac2 PF09729.4 EFX01233.1 - 0.45 10.3 4.4 0.18 11.6 0.4 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Zip PF02535.17 EFX01233.1 - 1.6 7.6 4.5 2.4 7.0 3.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ndufs5 PF10200.4 EFX01235.1 - 0.00044 20.1 0.0 0.00058 19.8 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa COX17 PF05051.8 EFX01235.1 - 0.027 14.4 0.3 0.045 13.7 0.2 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.8 EFX01235.1 - 0.031 14.1 0.1 0.059 13.3 0.1 1.5 1 1 0 1 1 1 0 CHCH domain COX6B PF02297.12 EFX01235.1 - 0.042 13.8 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb DUF3128 PF11326.3 EFX01235.1 - 0.13 12.4 0.2 0.21 11.7 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Nramp PF01566.13 EFX01236.1 - 6.3e-81 271.9 30.4 3.3e-50 170.8 7.4 2.6 3 0 0 3 3 3 2 Natural resistance-associated macrophage protein DUF2788 PF10981.3 EFX01236.1 - 0.053 13.3 0.3 0.053 13.3 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2788) Glyco_hydro_7 PF00840.15 EFX01237.1 - 7.8e-122 406.7 8.3 1.6e-63 214.5 1.6 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 7 FA_desaturase PF00487.19 EFX01239.1 - 2.1e-37 128.9 27.7 2.9e-37 128.5 19.2 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 EFX01239.1 - 2.2e-08 33.7 0.1 4.9e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ERG4_ERG24 PF01222.12 EFX01240.1 - 7.1e-137 456.4 17.0 9.1e-137 456.1 11.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family NPP1 PF05630.6 EFX01241.1 - 1.1e-57 195.1 0.0 1.4e-57 194.7 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) PQ-loop PF04193.9 EFX01242.1 - 2.3e-10 39.8 0.2 1.1e-05 24.8 0.0 2.6 2 0 0 2 2 2 2 PQ loop repeat Ank_2 PF12796.2 EFX01243.1 - 2.3e-60 200.9 15.5 4.6e-16 58.9 0.4 5.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX01243.1 - 1.4e-50 168.8 2.8 2.7e-10 40.4 0.0 6.2 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.25 EFX01243.1 - 6.1e-49 161.4 10.0 1.2e-06 27.9 0.0 9.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.1 EFX01243.1 - 9.2e-41 133.7 3.4 0.00029 20.7 0.0 9.4 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.1 EFX01243.1 - 7.5e-38 127.7 18.5 8.9e-07 28.9 0.0 8.2 2 1 7 9 9 9 8 Ankyrin repeats (many copies) DUF676 PF05057.9 EFX01243.1 - 0.00015 21.0 0.1 0.00038 19.8 0.0 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Cutinase PF01083.17 EFX01243.1 - 0.0028 17.4 0.0 0.0062 16.2 0.0 1.5 1 0 0 1 1 1 1 Cutinase Abhydrolase_6 PF12697.2 EFX01243.1 - 0.0036 17.2 0.0 0.0074 16.1 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Metallophos PF00149.23 EFX01244.1 - 1.6e-11 43.9 0.3 6.1e-06 25.7 0.0 2.5 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFX01244.1 - 1.5e-08 34.6 0.0 6e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Thioredoxin PF00085.15 EFX01245.1 - 2.2e-24 85.1 0.0 2.4e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFX01245.1 - 1.2e-06 28.6 0.3 4.4e-05 23.6 0.2 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX01245.1 - 3.7e-06 26.9 0.0 2.8e-05 24.1 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like HyaE PF07449.6 EFX01245.1 - 0.0032 17.3 0.0 0.0066 16.3 0.0 1.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.1 EFX01245.1 - 0.064 12.8 0.0 0.082 12.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.1 EFX01245.1 - 0.15 12.0 0.2 0.45 10.5 0.2 1.8 1 1 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.16 EFX01245.1 - 0.16 11.6 0.2 3.5 7.3 0.0 2.1 1 1 1 2 2 2 0 AhpC/TSA family Pox_MCEL PF03291.11 EFX01246.1 - 2.7e-63 213.8 0.0 6.6e-59 199.4 0.0 2.9 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.7 EFX01246.1 - 6.7e-08 32.9 0.2 0.0033 17.8 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.7 EFX01246.1 - 6.4e-07 29.7 0.0 1.4e-05 25.4 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01246.1 - 8.7e-07 29.5 0.0 4.4e-06 27.2 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01246.1 - 5.2e-06 26.2 0.0 1.3e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX01246.1 - 1.2e-05 25.5 0.0 5.1e-05 23.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX01246.1 - 2.3e-05 24.0 0.1 0.0019 17.7 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 EFX01246.1 - 0.00025 20.1 0.0 0.00043 19.3 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_26 PF13659.1 EFX01246.1 - 0.077 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Raftlin PF15250.1 EFX01246.1 - 0.079 11.4 2.2 0.097 11.1 0.0 1.8 2 0 0 2 2 2 0 Raftlin G-alpha PF00503.15 EFX01247.1 - 1.6e-114 382.6 0.1 2e-114 382.3 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EFX01247.1 - 1e-12 47.6 1.4 6.1e-08 32.0 0.0 2.6 2 2 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFX01247.1 - 0.0006 19.0 0.1 0.16 11.0 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 EFX01247.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 EFX01247.1 - 0.09 12.2 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_25 PF13481.1 EFX01247.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DOPA_dioxygen PF08883.6 EFX01248.1 - 8.2e-28 96.5 0.0 5e-22 77.9 0.0 2.1 2 0 0 2 2 2 2 Dopa 4,5-dioxygenase family Lactamase_B PF00753.22 EFX01249.1 - 9.6e-18 64.5 2.9 1.3e-17 64.1 2.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFX01249.1 - 0.0084 15.6 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Spermine_synth PF01564.12 EFX01250.1 - 1.6e-98 328.5 0.0 2.3e-98 328.0 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 EFX01250.1 - 0.00022 20.8 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01250.1 - 0.00055 20.4 0.0 0.00098 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 EFX01250.1 - 0.0045 16.2 0.3 0.066 12.3 0.1 2.3 1 1 1 2 2 2 1 O-methyltransferase Methyltransf_23 PF13489.1 EFX01250.1 - 0.0046 16.6 0.0 0.022 14.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX01250.1 - 0.0089 16.4 0.3 0.028 14.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.11 EFX01250.1 - 0.016 14.1 0.0 0.026 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF43 MTS PF05175.9 EFX01250.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain HECT PF00632.20 EFX01251.1 - 3.6e-69 233.3 0.0 5.5e-69 232.7 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RAP1 PF07218.6 EFX01251.1 - 0.32 9.0 1.4 0.57 8.2 1.0 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) E1-E2_ATPase PF00122.15 EFX01252.1 - 5.4e-31 107.4 6.2 6e-18 64.7 0.0 2.6 2 1 1 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.21 EFX01252.1 - 8.6e-30 104.7 0.0 2.3e-28 100.0 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 EFX01252.1 - 1.2e-23 83.6 8.7 1.2e-23 83.6 6.0 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus HAD PF12710.2 EFX01252.1 - 3e-16 60.1 0.0 7.5e-16 58.8 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EFX01252.1 - 9.5e-15 53.8 0.0 1.9e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 EFX01252.1 - 3.6e-14 52.4 0.0 6.5e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFX01252.1 - 2.2e-05 24.1 0.5 3.5e-05 23.5 0.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2157 PF09925.4 EFX01252.1 - 0.00082 18.9 0.6 0.00082 18.9 0.4 2.7 3 0 0 3 3 3 1 Predicted membrane protein (DUF2157) Metallophos PF00149.23 EFX01253.1 - 4.4e-39 133.9 0.0 6.2e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 EFX01253.1 - 1.4e-30 105.1 0.1 4.6e-30 103.4 0.0 1.9 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_11 PF13414.1 EFX01253.1 - 2.6e-22 78.2 8.6 6.4e-17 60.9 2.3 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFX01253.1 - 8.9e-10 37.7 4.5 0.0031 17.3 0.3 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX01253.1 - 1.4e-09 37.1 8.4 8e-05 22.0 0.2 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFX01253.1 - 1.9e-05 24.4 2.2 0.069 13.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX01253.1 - 0.0028 18.2 3.5 0.03 15.0 2.2 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX01253.1 - 0.003 17.8 2.7 1 9.7 1.1 3.0 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX01253.1 - 0.068 13.8 1.6 3.5 8.5 0.1 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 EFX01253.1 - 0.071 12.9 0.2 1 9.2 0.2 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Amidase PF01425.16 EFX01254.1 - 1.2e-79 268.2 4.6 3e-79 266.9 3.2 1.6 1 1 0 1 1 1 1 Amidase tRNA-synt_1 PF00133.17 EFX01255.1 - 3.3e-35 121.2 0.0 3.1e-24 84.9 0.0 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EFX01255.1 - 2e-17 62.9 0.0 8.6e-10 37.8 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EFX01255.1 - 1e-14 54.5 0.1 2.8e-14 53.1 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EFX01255.1 - 2.3e-06 26.9 0.0 3.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Prefoldin PF02996.12 EFX01256.1 - 6e-23 80.7 0.0 7.7e-23 80.4 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Cep57_MT_bd PF06657.8 EFX01256.1 - 0.012 15.5 0.1 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Prefoldin_2 PF01920.15 EFX01256.1 - 0.031 14.0 0.1 3.7 7.3 0.0 2.1 2 0 0 2 2 2 0 Prefoldin subunit Sec2p PF06428.6 EFX01256.1 - 0.035 13.9 1.1 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF3990 PF13151.1 EFX01256.1 - 0.074 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) DASH_Dam1 PF08653.5 EFX01256.1 - 0.13 12.0 0.1 9.3 6.1 0.0 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 Fzo_mitofusin PF04799.8 EFX01256.1 - 0.16 11.3 0.5 11 5.3 0.0 2.1 2 0 0 2 2 2 0 fzo-like conserved region Ribosomal_S14 PF00253.16 EFX01257.1 - 3.1e-18 64.8 3.3 3.1e-18 64.8 2.3 1.9 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Peptidase_M28 PF04389.12 EFX01258.1 - 4.6e-32 111.1 0.0 7.4e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EFX01258.1 - 0.003 17.1 0.0 0.007 15.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 MOSC PF03473.12 EFX01259.1 - 2.1e-11 43.3 0.0 3.7e-10 39.3 0.0 2.2 1 1 0 1 1 1 1 MOSC domain MOSC_N PF03476.11 EFX01259.1 - 1.8e-10 40.5 0.0 3.4e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain SNF2_N PF00176.18 EFX01261.1 - 4.7e-37 127.4 0.0 5.8e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Fibrillarin PF01269.12 EFX01262.1 - 5.7e-104 346.0 0.0 6.6e-104 345.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 EFX01262.1 - 1.1e-05 25.0 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 EFX01262.1 - 0.039 13.4 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 EFX01262.1 - 0.095 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain HisG PF01634.13 EFX01263.1 - 4e-48 163.0 0.0 2.7e-38 131.1 0.0 2.5 2 0 0 2 2 2 2 ATP phosphoribosyltransferase HisG_C PF08029.6 EFX01263.1 - 4.3e-28 97.0 0.2 1.1e-27 95.7 0.1 1.7 1 0 0 1 1 1 1 HisG, C-terminal domain ATP-synt_D PF01813.12 EFX01264.1 - 0.0018 17.8 4.1 0.0026 17.3 2.4 1.5 1 1 0 1 1 1 1 ATP synthase subunit D LOH1CR12 PF10158.4 EFX01264.1 - 0.016 14.9 4.0 0.04 13.7 1.7 2.1 1 1 1 2 2 2 0 Tumour suppressor protein HR1 PF02185.11 EFX01264.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.6 2 0 0 2 2 2 0 Hr1 repeat Myb_DNA-bind_3 PF12776.2 EFX01264.1 - 0.15 12.6 0.6 0.29 11.7 0.4 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain KLRAQ PF10205.4 EFX01264.1 - 2.1 8.4 8.1 12 5.9 0.2 2.7 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Fib_alpha PF08702.5 EFX01264.1 - 2.1 8.4 4.7 2.6 8.1 2.5 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1515 PF07439.6 EFX01264.1 - 2.3 8.0 3.9 1.6 8.5 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) APG6 PF04111.7 EFX01264.1 - 6.2 5.7 12.6 10 5.0 8.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.6 EFX01264.1 - 7.1 5.1 13.0 12 4.4 9.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Fungal_trans_2 PF11951.3 EFX01265.1 - 0.11 11.1 0.1 0.2 10.2 0.1 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01266.1 - 0.0021 17.8 7.2 0.0044 16.9 5.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDK5_activator PF03261.10 EFX01266.1 - 0.17 11.1 2.3 0.3 10.3 1.6 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Herpes_BMRF2 PF04633.7 EFX01266.1 - 0.27 10.1 0.0 0.42 9.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus BMRF2 protein BAF1_ABF1 PF04684.8 EFX01266.1 - 5.1 5.8 19.9 8.3 5.1 13.8 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NB-ARC PF00931.17 EFX01267.1 - 3.3e-09 36.0 0.0 5.3e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 EFX01267.1 - 2e-08 34.4 0.0 2.3e-07 30.9 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 EFX01267.1 - 6e-08 32.8 4.4 2.6e-05 24.2 0.0 3.1 1 1 1 2 2 2 2 AAA ATPase domain NACHT PF05729.7 EFX01267.1 - 0.0011 18.6 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Abhydrolase_6 PF12697.2 EFX01267.1 - 0.0012 18.7 0.0 0.004 17.0 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 EFX01267.1 - 0.0012 18.1 0.0 0.0026 17.0 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EFX01267.1 - 0.011 15.3 0.0 0.027 14.0 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Arch_ATPase PF01637.13 EFX01267.1 - 0.024 14.3 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase IstB_IS21 PF01695.12 EFX01267.1 - 0.027 13.8 0.0 0.071 12.5 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein SRP54 PF00448.17 EFX01267.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Peptidase_M22 PF00814.20 EFX01268.1 - 1.1e-80 271.0 0.0 1.3e-80 270.7 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family G-patch PF01585.18 EFX01269.1 - 2.3e-08 33.6 1.5 4.9e-08 32.6 1.1 1.5 1 0 0 1 1 1 1 G-patch domain RRM_5 PF13893.1 EFX01269.1 - 6.4e-06 25.9 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX01269.1 - 0.00028 20.4 0.0 0.00049 19.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01269.1 - 0.042 13.8 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CactinC_cactus PF09732.4 EFX01270.1 - 1.7e-54 182.7 2.3 2.9e-54 181.9 1.6 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.4 EFX01270.1 - 4.8e-54 182.5 0.5 6.5e-54 182.1 0.3 1.2 1 0 0 1 1 1 1 Conserved mid region of cactin DUF1087 PF06465.8 EFX01270.1 - 0.051 13.5 1.0 0.23 11.4 0.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) 7tm_2 PF00002.19 EFX01272.1 - 1.1e-13 50.8 3.6 1.1e-13 50.8 2.5 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 EFX01272.1 - 3.1e-11 42.7 7.1 3.1e-11 42.7 4.9 1.7 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor Git3 PF11710.3 EFX01272.1 - 1.6e-08 34.3 7.1 3.4e-08 33.3 4.9 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 EFX01272.1 - 3.8e-07 29.5 11.8 6.2e-07 28.8 6.2 2.1 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.4 EFX01272.1 - 3.8e-06 26.2 2.0 6.9e-06 25.4 1.4 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Oxidored_q5_N PF01059.12 EFX01272.1 - 0.12 12.2 0.2 0.12 12.2 0.1 2.6 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus Bd3614-deam PF14439.1 EFX01272.1 - 1.6 8.6 4.9 2.9 7.7 2.9 1.8 1 1 0 1 1 1 0 Bd3614-like deaminase MFS_1 PF07690.11 EFX01273.1 - 7e-14 51.3 32.6 1.8e-07 30.2 17.6 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily IF4E PF01652.13 EFX01274.1 - 1.5e-47 161.1 0.0 2e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1917 PF08939.5 EFX01274.1 - 0.017 14.8 0.1 0.027 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) Amidohydro_4 PF13147.1 EFX01275.1 - 2.1e-15 57.4 1.4 1.9e-06 28.1 0.4 2.4 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EFX01275.1 - 1.5e-08 34.6 0.0 6.9e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 EFX01275.1 - 1.2e-06 28.0 0.0 2.2e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EFX01275.1 - 3e-05 23.7 0.1 0.00011 21.9 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase Fungal_trans_2 PF11951.3 EFX01276.1 - 2e-08 33.2 0.1 3.4e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01276.1 - 6.9e-08 32.2 10.9 1.1e-07 31.6 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cellulase PF00150.13 EFX01279.1 - 1.8e-13 50.3 1.0 3.9e-13 49.2 0.7 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ETRAMP PF09716.5 EFX01279.1 - 0.18 11.7 2.3 0.43 10.5 1.6 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3632 PF12311.3 EFX01281.1 - 3.3e-08 33.5 1.8 4.3e-08 33.1 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Acetyltransf_1 PF00583.19 EFX01282.1 - 2.9e-09 36.8 0.0 1.3e-05 25.1 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFX01282.1 - 3.4e-06 27.1 0.1 0.0002 21.4 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFX01282.1 - 0.00033 20.7 0.0 0.00066 19.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX01282.1 - 0.00041 20.2 1.0 0.11 12.3 0.1 3.5 2 2 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX01282.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein YCII PF03795.9 EFX01283.1 - 7.2e-07 29.3 0.0 9.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain adh_short PF00106.20 EFX01284.1 - 5.3e-30 104.5 1.5 8.7e-30 103.8 1.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01284.1 - 3.8e-27 95.5 0.1 5.2e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01284.1 - 9.7e-12 44.9 0.4 1.5e-11 44.2 0.3 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX01284.1 - 6.6e-06 25.7 0.4 1.7e-05 24.3 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PA PF02225.17 EFX01284.1 - 0.0004 20.0 0.6 0.0014 18.3 0.2 2.1 2 0 0 2 2 2 1 PA domain Polysacc_synt_2 PF02719.10 EFX01284.1 - 0.0033 16.3 0.0 0.005 15.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 EFX01284.1 - 0.01 14.5 0.1 0.013 14.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Gly_rich_SFCGS PF14272.1 EFX01284.1 - 0.083 12.7 0.5 0.18 11.6 0.4 1.6 1 0 0 1 1 1 0 Glycine-rich SFCGS Pyridox_ox_2 PF12900.2 EFX01284.1 - 0.13 12.0 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase L_HGMIC_fpl PF10242.4 EFX01286.1 - 0.00015 21.8 0.6 0.00015 21.8 0.5 1.7 2 0 0 2 2 2 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.1 EFX01286.1 - 0.0044 16.7 7.8 0.019 14.6 5.1 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction MARVEL PF01284.18 EFX01286.1 - 0.012 15.4 3.5 0.012 15.4 2.5 2.6 2 1 0 3 3 3 0 Membrane-associating domain Spc97_Spc98 PF04130.8 EFX01287.1 - 1.9e-64 217.9 0.0 3.1e-64 217.2 0.0 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family GCP5-Mod21 PF14609.1 EFX01287.1 - 0.028 12.5 0.0 0.061 11.4 0.0 1.5 1 1 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 p450 PF00067.17 EFX01288.1 - 2.5e-40 138.3 0.0 5.3e-40 137.3 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 tRNA-synt_2b PF00587.20 EFX01289.1 - 1.3e-32 112.7 0.0 2e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EFX01289.1 - 9.7e-19 67.3 7.6 9.7e-19 67.3 5.3 2.4 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain DUF2236 PF09995.4 EFX01291.1 - 3.1e-06 26.6 0.0 7.5e-06 25.4 0.0 1.6 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2236) ANTH PF07651.11 EFX01291.1 - 0.056 12.1 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 ANTH domain ICE2 PF08426.5 EFX01292.1 - 4.1e-132 440.6 7.0 4.9e-132 440.4 4.9 1.0 1 0 0 1 1 1 1 ICE2 Peptidase_M14 PF00246.19 EFX01293.1 - 6e-62 209.7 0.0 7.7e-62 209.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase SKG6 PF08693.5 EFX01294.1 - 0.0037 16.5 0.0 0.011 15.0 0.0 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Gly-zipper_OmpA PF13436.1 EFX01294.1 - 0.065 12.9 11.5 0.41 10.3 2.8 2.8 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Yip1 PF04893.12 EFX01294.1 - 0.15 11.5 1.7 0.33 10.4 0.2 2.0 2 0 0 2 2 2 0 Yip1 domain TrbC PF04956.8 EFX01294.1 - 0.53 10.3 4.5 0.48 10.4 0.5 2.4 2 0 0 2 2 2 0 TrbC/VIRB2 family Gly-zipper_YMGG PF13441.1 EFX01294.1 - 0.75 9.3 19.3 0.89 9.1 3.2 2.5 2 0 0 2 2 2 0 YMGG-like Gly-zipper P12 PF12669.2 EFX01294.1 - 0.93 9.7 5.2 3.7 7.8 0.0 2.6 2 0 0 2 2 2 0 Virus attachment protein p12 family Macoilin PF09726.4 EFX01294.1 - 5.8 5.0 6.4 7.6 4.6 4.5 1.1 1 0 0 1 1 1 0 Transmembrane protein ATP-synt_C PF00137.16 EFX01295.1 - 6.4e-32 109.2 29.4 4.9e-19 67.9 9.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C ABA_GPCR PF12430.3 EFX01295.1 - 0.052 12.6 1.0 2.8 7.0 0.1 2.1 2 0 0 2 2 2 0 Abscisic acid G-protein coupled receptor Flavi_NS4A PF01350.12 EFX01295.1 - 0.056 13.0 0.5 0.056 13.0 0.3 1.7 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4A ECH PF00378.15 EFX01296.1 - 1.1e-43 149.1 0.2 3.2e-41 141.0 0.1 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase family SNF2_N PF00176.18 EFX01297.1 - 8e-55 185.7 0.0 1.4e-54 184.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.1 EFX01297.1 - 4.9e-24 84.0 0.3 1.8e-23 82.2 0.2 2.0 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.26 EFX01297.1 - 2e-14 53.2 0.6 7.3e-14 51.3 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX01297.1 - 0.0005 19.9 0.1 0.028 14.2 0.0 3.4 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit NYN PF01936.13 EFX01298.1 - 0.00098 19.4 0.0 0.015 15.6 0.0 2.3 1 1 0 1 1 1 1 NYN domain Fijivirus_P9-2 PF06837.6 EFX01298.1 - 0.27 10.3 0.1 0.44 9.6 0.1 1.2 1 0 0 1 1 1 0 Fijivirus P9-2 protein Complex1_30kDa PF00329.14 EFX01299.1 - 1.7e-35 121.3 0.1 2.4e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit CoA_transf_3 PF02515.12 EFX01300.1 - 1e-49 168.4 0.4 2.2e-49 167.2 0.2 1.6 1 0 0 1 1 1 1 CoA-transferase family III DrrA_P4M PF14860.1 EFX01301.1 - 0.028 14.1 0.4 0.28 10.9 0.0 2.2 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain IncA PF04156.9 EFX01302.1 - 0.087 12.4 6.0 0.021 14.4 1.5 1.9 2 0 0 2 2 2 0 IncA protein DUF515 PF04415.7 EFX01302.1 - 0.11 10.6 1.4 0.19 9.9 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF4315 PF14193.1 EFX01302.1 - 0.45 10.4 7.5 0.64 9.9 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4315) PilO PF04350.8 EFX01302.1 - 0.84 9.5 5.0 0.33 10.8 0.3 2.3 1 1 1 2 2 2 0 Pilus assembly protein, PilO DUF342 PF03961.8 EFX01302.1 - 0.93 7.8 2.6 1.7 6.9 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4085 PF13315.1 EFX01302.1 - 1.4 8.2 7.7 0.22 10.8 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4085) Cortex-I_coil PF09304.5 EFX01302.1 - 1.7 8.7 12.0 0.16 12.0 3.2 2.8 2 2 0 2 2 2 0 Cortexillin I, coiled coil Prefoldin_2 PF01920.15 EFX01302.1 - 6.3 6.6 11.9 1 9.1 1.1 2.9 2 1 1 3 3 3 0 Prefoldin subunit adh_short PF00106.20 EFX01303.1 - 2.5e-24 86.0 8.9 3.3e-24 85.6 6.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01303.1 - 3e-21 76.3 0.1 5e-21 75.5 0.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01303.1 - 8.5e-12 45.0 6.2 1.4e-11 44.4 4.3 1.3 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 EFX01303.1 - 0.00011 21.8 4.4 0.2 11.4 0.1 2.4 2 0 0 2 2 2 2 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Glyco_transf_8 PF01501.15 EFX01305.1 - 1.1e-39 136.2 0.0 2e-39 135.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 EFX01305.1 - 0.003 16.9 1.1 0.0033 16.8 0.0 1.6 2 0 0 2 2 2 1 Mannosyltransferase putative Fungal_trans PF04082.13 EFX01306.1 - 1.6e-28 99.2 0.1 2.3e-28 98.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01306.1 - 1e-07 31.7 11.9 1.6e-07 31.0 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1_like PF12832.2 EFX01307.1 - 3.4e-10 39.5 7.6 5.5e-07 29.2 0.0 3.5 3 0 0 3 3 3 2 MFS_1 like family IGR PF09597.5 EFX01308.1 - 5.3e-23 80.6 0.0 7.6e-23 80.1 0.0 1.2 1 0 0 1 1 1 1 IGR protein motif SAM_1 PF00536.25 EFX01308.1 - 0.1 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2890 PF11081.3 EFX01308.1 - 0.67 9.9 2.7 0.42 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Ank_2 PF12796.2 EFX01309.1 - 3.2e-70 232.4 8.7 7.1e-16 58.3 0.0 6.2 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01309.1 - 1.3e-65 214.1 22.8 8.1e-09 34.8 0.0 12.7 12 0 0 12 12 12 10 Ankyrin repeat Ank_4 PF13637.1 EFX01309.1 - 7.9e-55 182.3 11.2 1.4e-10 41.3 0.0 9.9 5 3 6 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX01309.1 - 1.1e-53 177.9 17.1 5.3e-12 45.5 0.1 9.4 3 3 7 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX01309.1 - 7.4e-49 158.8 11.9 0.00013 21.8 0.0 12.9 12 0 0 12 12 12 9 Ankyrin repeat NACHT PF05729.7 EFX01309.1 - 0.0036 16.9 0.0 0.0091 15.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NifQ PF04891.7 EFX01309.1 - 0.027 14.6 0.3 0.084 13.0 0.2 1.8 1 0 0 1 1 1 0 NifQ Lipase_3 PF01764.20 EFX01310.1 - 4e-27 94.5 0.0 6.2e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Cutinase PF01083.17 EFX01310.1 - 0.018 14.7 0.1 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 Cutinase PE-PPE PF08237.6 EFX01310.1 - 0.047 13.1 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_8 PF06259.7 EFX01310.1 - 0.06 12.8 0.3 0.1 12.0 0.2 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_5 PF12695.2 EFX01310.1 - 0.077 12.7 0.5 0.14 11.8 0.3 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family chaperone_DMP PF10448.4 EFX01311.1 - 0.14 12.0 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 20S proteasome chaperone TTL PF03133.10 EFX01312.1 - 3.2e-51 173.9 0.0 4.8e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 EFX01312.1 - 1.9e-43 148.0 0.0 2.8e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ATP-grasp_4 PF13535.1 EFX01312.1 - 0.004 16.9 0.0 0.0091 15.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Glyco_transf_28 PF03033.15 EFX01312.1 - 0.018 14.7 0.0 0.052 13.3 0.0 1.9 1 1 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Nucleoplasmin PF03066.10 EFX01312.1 - 0.097 12.1 3.9 0.19 11.2 2.7 1.4 1 0 0 1 1 1 0 Nucleoplasmin RXT2_N PF08595.6 EFX01312.1 - 0.14 11.9 1.8 0.27 11.0 1.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Nro1 PF12753.2 EFX01312.1 - 0.14 11.0 1.5 0.22 10.4 1.1 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Glyco_trans_4_4 PF13579.1 EFX01312.1 - 0.56 10.3 15.0 1 9.5 3.0 3.1 2 1 1 3 3 3 0 Glycosyl transferase 4-like domain DUF2457 PF10446.4 EFX01312.1 - 8.2 5.0 12.1 14 4.2 8.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 EFX01312.1 - 8.6 5.5 6.7 21 4.2 4.7 1.6 1 0 0 1 1 1 0 NOA36 protein Ribosomal_L7Ae PF01248.21 EFX01313.1 - 5.2e-15 54.7 5.6 7.2e-15 54.2 1.1 2.8 2 1 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SOBP PF15279.1 EFX01313.1 - 0.74 10.1 5.2 0.95 9.7 3.6 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4054 PF13262.1 EFX01313.1 - 2.6 8.3 6.8 13 6.1 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF4054) DUF4613 PF15390.1 EFX01313.1 - 3.9 5.5 8.7 4.8 5.2 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Myosin_head PF00063.16 EFX01314.1 - 1.3e-239 796.9 0.2 1.3e-239 796.9 0.2 1.6 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.14 EFX01314.1 - 9.5e-35 118.6 3.4 2.9e-34 117.0 2.3 1.9 1 0 0 1 1 1 1 DIL domain IQ PF00612.22 EFX01314.1 - 1.2e-12 46.2 33.4 0.0001 21.5 0.3 7.0 6 0 0 6 6 6 4 IQ calmodulin-binding motif ERM PF00769.14 EFX01314.1 - 8.7e-07 28.7 13.3 8.7e-07 28.7 9.2 2.5 2 0 0 2 2 2 1 Ezrin/radixin/moesin family CALCOCO1 PF07888.6 EFX01314.1 - 0.00022 19.6 17.6 0.00022 19.6 12.2 1.9 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like AAA_22 PF13401.1 EFX01314.1 - 0.00073 19.6 1.2 0.0018 18.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.1 EFX01314.1 - 0.0024 16.4 16.1 0.0066 14.9 11.2 1.7 1 0 0 1 1 1 1 AAA domain FlaC_arch PF05377.6 EFX01314.1 - 0.0041 16.9 0.1 0.0041 16.9 0.1 4.0 4 1 0 4 4 3 1 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.7 EFX01314.1 - 0.0063 16.3 13.1 0.13 12.1 9.1 2.9 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_19 PF13245.1 EFX01314.1 - 0.0096 15.6 0.0 0.033 13.9 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain Reo_sigmaC PF04582.7 EFX01314.1 - 0.036 13.2 5.9 0.14 11.3 2.4 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein GAS PF13851.1 EFX01314.1 - 0.14 11.3 34.1 0.019 14.1 18.3 3.0 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding ABC_tran PF00005.22 EFX01314.1 - 0.16 12.2 5.4 1.1 9.5 0.0 3.0 2 0 0 2 2 2 0 ABC transporter Fez1 PF06818.10 EFX01314.1 - 0.17 11.9 30.3 0.11 12.4 16.1 3.3 2 1 0 2 2 2 0 Fez1 Spc7 PF08317.6 EFX01314.1 - 0.64 8.6 27.3 0.013 14.1 13.6 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.4 EFX01314.1 - 2.3 8.0 37.2 0.5 10.2 8.7 3.1 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Atg14 PF10186.4 EFX01314.1 - 8.1 5.2 20.6 25 3.6 14.3 1.9 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ADIP PF11559.3 EFX01314.1 - 8.7 6.2 35.3 0.27 11.1 9.0 3.6 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.16 EFX01315.1 - 1.3e-13 50.6 3.8 2e-13 50.1 2.7 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX01315.1 - 1.4e-06 28.0 5.5 2.2e-06 27.3 3.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper Aminotran_1_2 PF00155.16 EFX01316.1 - 9.4e-09 34.6 0.0 4.5e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class I and II EPL1 PF10513.4 EFX01317.1 - 1.2e-31 110.0 9.5 1.3e-31 110.0 2.1 2.8 2 1 0 2 2 2 2 Enhancer of polycomb-like Acyl-CoA_dh_N PF02771.11 EFX01318.1 - 5.6e-24 84.8 0.9 1.3e-23 83.6 0.6 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.19 EFX01318.1 - 2.6e-23 82.8 2.8 4.2e-23 82.0 1.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFX01318.1 - 2.7e-17 61.9 0.0 7.2e-17 60.6 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFX01318.1 - 7.4e-07 29.4 4.3 1.3e-06 28.7 3.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DnaJ PF00226.26 EFX01319.1 - 8e-22 76.7 0.9 1.7e-21 75.6 0.6 1.6 1 0 0 1 1 1 1 DnaJ domain MIP-T3 PF10243.4 EFX01319.1 - 0.0044 15.5 52.7 0.0076 14.7 36.5 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Zn_clus PF00172.13 EFX01320.1 - 3e-07 30.2 8.6 5.1e-07 29.5 5.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydantoinase_B PF02538.9 EFX01321.1 - 7.3e-189 628.3 0.0 9.8e-189 627.9 0.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EFX01321.1 - 6.2e-92 307.7 1.0 9.9e-92 307.1 0.1 1.9 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFX01321.1 - 4.9e-53 179.2 0.0 3.7e-51 173.1 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region SNF2_N PF00176.18 EFX01322.1 - 7.1e-33 113.6 0.2 1.4e-27 96.2 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX01322.1 - 2e-12 46.8 0.3 9.1e-10 38.2 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 EFX01322.1 - 6e-05 22.5 0.0 0.00026 20.5 0.0 2.0 2 1 1 3 3 3 1 DEAD/DEAH box helicase DUF3152 PF11350.3 EFX01322.1 - 0.0018 17.8 0.0 0.42 10.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3152) AAA_34 PF13872.1 EFX01322.1 - 0.058 12.1 0.2 0.24 10.1 0.1 1.9 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 ResIII PF04851.10 EFX01322.1 - 0.096 12.5 0.0 0.31 10.8 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AMPKBI PF04739.10 EFX01323.1 - 1.8e-28 98.3 0.4 1.8e-28 98.3 0.3 2.9 3 0 0 3 3 3 1 5'-AMP-activated protein kinase beta subunit, interation domain CPSF100_C PF13299.1 EFX01323.1 - 1.3 9.1 10.1 3.6 7.7 7.0 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ndc1_Nup PF09531.5 EFX01323.1 - 4.5 5.5 11.1 8.5 4.6 7.7 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.8 EFX01323.1 - 5 6.9 27.8 0.22 11.3 11.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.9 EFX01323.1 - 5.4 6.6 14.9 11 5.6 10.3 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PIH1 PF08190.7 EFX01323.1 - 5.5 6.3 17.2 10 5.4 11.9 1.4 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 NAD_binding_1 PF00175.16 EFX01324.1 - 2e-05 25.1 0.0 0.044 14.3 0.0 2.7 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EFX01324.1 - 0.00012 21.9 0.0 0.0037 17.1 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 EFX01324.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain CHZ PF09649.5 EFX01326.1 - 0.0047 16.1 1.2 0.016 14.4 0.1 2.5 2 0 0 2 2 2 1 Histone chaperone domain CHZ AAA PF00004.24 EFX01327.1 - 6.7e-15 55.4 0.0 1.5e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFX01327.1 - 3.1e-10 40.3 0.2 1.9e-09 37.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX01327.1 - 2.8e-07 30.7 0.0 7.1e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain BAH PF01426.13 EFX01327.1 - 7.5e-07 28.9 0.0 1.7e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 BAH domain AAA_17 PF13207.1 EFX01327.1 - 6.4e-05 23.7 0.0 0.00098 19.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 EFX01327.1 - 0.0031 17.2 0.4 0.0031 17.2 0.3 3.2 3 0 0 3 3 3 1 Part of AAA domain AAA_33 PF13671.1 EFX01327.1 - 0.012 15.4 0.1 0.51 10.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 EFX01327.1 - 0.017 14.7 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 EFX01327.1 - 0.018 15.3 0.0 0.045 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFX01327.1 - 0.026 14.2 0.0 0.36 10.4 0.0 2.4 1 1 0 1 1 1 0 Archaeal ATPase AAA_11 PF13086.1 EFX01327.1 - 0.028 14.0 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 EFX01327.1 - 0.028 13.4 0.0 0.047 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.1 EFX01327.1 - 0.029 14.3 0.1 0.099 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EFX01327.1 - 0.039 13.3 0.0 0.11 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain Zot PF05707.7 EFX01327.1 - 0.05 13.0 0.0 0.085 12.3 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_32 PF13654.1 EFX01327.1 - 0.054 12.1 0.0 0.087 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Choline_kinase PF01633.15 EFX01328.1 - 3e-47 160.9 0.0 2.4e-46 157.9 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 EFX01328.1 - 4.5e-11 42.9 3.1 4.5e-11 42.9 2.1 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFX01328.1 - 0.04 13.0 0.0 0.088 11.9 0.0 1.5 1 1 0 1 1 1 0 Ecdysteroid kinase DUF3439 PF11921.3 EFX01328.1 - 8.1 6.2 18.1 5.7 6.7 4.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) F-box PF00646.28 EFX01329.1 - 1.4e-07 30.9 0.3 3.9e-07 29.5 0.0 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EFX01329.1 - 0.00056 19.5 1.3 0.0014 18.2 0.0 2.4 2 0 0 2 2 2 1 F-box-like Ribosomal_60s PF00428.14 EFX01330.1 - 2.2e-28 98.4 9.0 2.7e-28 98.2 6.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DIOX_N PF14226.1 EFX01331.1 - 4.1e-25 88.5 0.0 6.7e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX01331.1 - 2.9e-23 82.0 0.0 2e-22 79.3 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Myb_DNA-binding PF00249.26 EFX01333.1 - 2.4e-18 65.8 0.4 8e-08 32.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX01333.1 - 1.9e-14 53.5 4.2 3.5e-09 36.6 0.1 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.3 EFX01333.1 - 0.068 13.1 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) p450 PF00067.17 EFX01334.1 - 6e-57 193.1 0.0 7.6e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PC4 PF02229.11 EFX01334.1 - 0.14 11.3 0.5 1.1 8.4 0.1 2.5 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) TFIIE_alpha PF02002.12 EFX01335.1 - 3.4e-18 65.0 0.4 6.8e-18 64.1 0.2 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit FAM176 PF14851.1 EFX01335.1 - 9.5 5.8 7.9 0.95 9.1 0.4 2.6 3 0 0 3 3 3 0 FAM176 family DNA_ligase_A_M PF01068.16 EFX01337.1 - 4e-46 156.9 0.0 5.9e-44 149.8 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFX01337.1 - 7.6e-37 126.8 0.0 1.6e-36 125.7 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EFX01337.1 - 4.8e-17 62.1 0.2 1.3e-14 54.3 0.0 3.5 3 1 0 3 3 3 1 ATP dependent DNA ligase C terminal region Sigma70_ner PF04546.8 EFX01337.1 - 0.0027 17.3 1.5 0.0027 17.3 1.0 2.2 3 0 0 3 3 3 1 Sigma-70, non-essential region NOA36 PF06524.7 EFX01337.1 - 0.33 10.1 2.3 0.68 9.1 1.6 1.4 1 0 0 1 1 1 0 NOA36 protein Velvet PF11754.3 EFX01338.1 - 1.3e-53 181.6 3.0 1.1e-52 178.6 2.1 2.3 1 1 0 1 1 1 1 Velvet factor GATase_4 PF13230.1 EFX01339.1 - 1.6e-19 69.6 0.0 7.3e-18 64.2 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 EFX01339.1 - 4.4e-10 39.6 0.0 1.1e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 EFX01339.1 - 2.6e-05 23.0 0.1 0.00019 20.2 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Ras PF00071.17 EFX01340.1 - 4.7e-44 149.6 0.0 5.3e-44 149.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX01340.1 - 1.1e-13 51.7 0.1 1.4e-13 51.3 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX01340.1 - 2.4e-07 30.1 0.0 2.7e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFX01340.1 - 5.5e-06 26.3 0.0 7.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 EFX01340.1 - 0.0014 17.8 0.0 0.0025 17.0 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 EFX01340.1 - 0.002 17.5 0.1 0.019 14.4 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.1 EFX01340.1 - 0.068 13.0 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 EFX01340.1 - 0.095 11.9 0.0 0.74 9.0 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF3753 PF12575.3 EFX01341.1 - 0.043 13.6 2.5 0.11 12.3 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) VirB3 PF05101.8 EFX01341.1 - 0.098 12.6 0.6 0.34 10.9 0.4 1.9 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Gag_p24 PF00607.15 EFX01341.1 - 0.6 9.6 2.1 33 3.9 0.0 3.0 4 0 0 4 4 4 0 gag gene protein p24 (core nucleocapsid protein) WD40 PF00400.27 EFX01342.1 - 1.4e-46 154.7 20.1 5.8e-08 32.3 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 EFX01342.1 - 6.7e-41 139.6 0.0 9.4e-41 139.2 0.0 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit eIF2A PF08662.6 EFX01342.1 - 1.4e-05 24.8 0.1 0.0044 16.7 0.0 3.6 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 EFX01342.1 - 0.00032 19.5 0.1 0.26 9.9 0.0 2.6 2 2 0 2 2 2 2 Nup133 N terminal like LisH PF08513.6 EFX01342.1 - 0.0016 18.1 0.1 0.0045 16.7 0.1 1.8 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 EFX01342.1 - 0.23 9.5 2.4 12 3.8 0.3 3.1 2 1 0 3 3 3 0 Nucleoporin Nup120/160 Hexokinase_2 PF03727.11 EFX01343.1 - 6.2e-34 117.2 0.0 7.6e-28 97.3 0.0 2.2 1 1 1 2 2 2 2 Hexokinase Hexokinase_1 PF00349.16 EFX01343.1 - 9.2e-29 100.2 0.0 1.3e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase HEAT_EZ PF13513.1 EFX01344.1 - 1.7e-29 101.5 29.1 7e-16 58.2 0.0 11.4 9 2 5 14 14 13 6 HEAT-like repeat HEAT PF02985.17 EFX01344.1 - 5e-27 91.5 9.3 0.00038 20.2 0.0 9.4 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.1 EFX01344.1 - 3.9e-26 91.1 7.4 2.6e-08 34.0 0.0 7.7 4 3 3 7 7 7 6 HEAT repeats Vac14_Fab1_bd PF12755.2 EFX01344.1 - 1.5e-07 31.6 0.0 0.022 15.1 0.0 5.6 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 EFX01344.1 - 1.8e-05 24.6 0.0 14 5.5 0.0 5.6 3 2 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.14 EFX01344.1 - 5.3e-05 23.0 0.0 0.0069 16.2 0.0 4.0 2 1 1 3 3 3 1 Importin-beta N-terminal domain Arm PF00514.18 EFX01344.1 - 0.00015 21.4 9.7 0.54 10.1 0.0 6.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat MMS19_C PF12460.3 EFX01344.1 - 0.0006 18.6 0.0 1.7 7.3 0.1 3.5 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal HEAT_PBS PF03130.11 EFX01344.1 - 0.0049 17.2 4.4 29 5.5 0.0 5.6 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat CLASP_N PF12348.3 EFX01344.1 - 0.0073 15.6 0.0 53 3.0 0.0 5.0 5 0 0 5 5 5 0 CLASP N terminal DUF2435 PF10363.4 EFX01344.1 - 0.1 12.5 0.0 0.37 10.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2435) Slx4 PF09494.5 EFX01345.1 - 2.5e-19 68.7 0.1 4.5e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Slx4 endonuclease Mur_ligase_M PF08245.7 EFX01346.1 - 0.00011 22.3 0.1 0.00033 20.7 0.0 1.9 1 1 0 1 1 1 1 Mur ligase middle domain Dynamin_N PF00350.18 EFX01347.1 - 5.8e-28 97.8 0.4 1.9e-27 96.1 0.3 1.9 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFX01347.1 - 3.6e-16 58.8 0.0 7.3e-15 54.5 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 EFX01347.1 - 1.6e-05 24.8 0.0 6.7e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.13 EFX01347.1 - 0.00061 19.6 1.6 0.0022 17.8 0.0 2.6 3 0 0 3 3 3 1 Dynamin GTPase effector domain FeoB_N PF02421.13 EFX01347.1 - 0.0021 17.3 0.1 0.19 11.0 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 EFX01347.1 - 0.0051 17.2 0.0 0.019 15.4 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein AAA_23 PF13476.1 EFX01347.1 - 0.028 14.7 0.6 0.19 12.0 0.4 2.2 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.1 EFX01347.1 - 0.089 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EFX01347.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain VHS PF00790.14 EFX01348.1 - 8.9e-32 109.6 5.7 7.4e-31 106.6 0.4 3.1 2 1 1 3 3 3 1 VHS domain FYVE PF01363.16 EFX01348.1 - 2e-15 56.4 3.8 3.4e-15 55.6 2.6 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.15 EFX01348.1 - 2.8e-05 23.2 18.5 0.0032 16.9 0.8 3.4 3 0 0 3 3 3 2 Ubiquitin interaction motif zf-DHHC PF01529.15 EFX01348.1 - 0.0034 16.8 1.8 0.0074 15.6 1.3 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ribonuc_L-PSP PF01042.16 EFX01349.1 - 0.12 12.1 3.7 0.92 9.2 0.4 2.5 2 0 0 2 2 2 0 Endoribonuclease L-PSP DHHW PF14286.1 EFX01349.1 - 0.34 10.1 2.3 0.58 9.4 1.6 1.3 1 0 0 1 1 1 0 DHHW protein Bax1-I PF01027.15 EFX01350.1 - 6.9e-33 113.9 9.1 1.1e-32 113.2 6.3 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Ndc80_HEC PF03801.8 EFX01351.1 - 6.4e-58 194.7 0.2 1.8e-57 193.2 0.0 1.9 2 0 0 2 2 2 1 HEC/Ndc80p family WASH_WAHD PF11945.3 EFX01351.1 - 0.0049 16.2 3.4 0.0049 16.2 2.3 1.8 2 0 0 2 2 2 1 WAHD domain of WASH complex DUF1664 PF07889.7 EFX01351.1 - 0.03 14.1 0.3 0.03 14.1 0.2 5.1 3 2 3 6 6 6 0 Protein of unknown function (DUF1664) NAAA-beta PF15508.1 EFX01351.1 - 0.2 11.9 3.1 28 5.1 0.1 3.8 4 0 0 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Spc7 PF08317.6 EFX01351.1 - 5.2 5.6 40.5 1.4 7.5 10.8 2.8 2 1 0 2 2 2 0 Spc7 kinetochore protein ATG16 PF08614.6 EFX01351.1 - 5.7 6.7 40.5 1.3 8.7 8.2 3.7 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) PLAC9 PF15205.1 EFX01351.1 - 6.6 7.0 6.1 16 5.8 0.0 3.6 3 0 0 3 3 3 0 Placenta-specific protein 9 ICL PF00463.16 EFX01352.1 - 4.7e-254 843.4 2.0 8.4e-254 842.6 1.4 1.4 1 1 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 EFX01352.1 - 3.6e-11 42.7 0.1 8.5e-11 41.5 0.1 1.6 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase BAR_2 PF10455.4 EFX01353.1 - 0.1 11.5 0.2 0.17 10.7 0.2 1.2 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Rubis-subs-bind PF09273.6 EFX01354.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding DUF500 PF04366.7 EFX01355.1 - 7.1e-43 145.0 0.1 1.2e-42 144.3 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) SH3_1 PF00018.23 EFX01355.1 - 2e-14 52.6 0.2 5.4e-14 51.3 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 EFX01355.1 - 4.9e-13 48.4 0.0 8.3e-13 47.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFX01355.1 - 1.2e-12 47.1 0.0 2.8e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Sec23_trunk PF04811.10 EFX01356.1 - 6.4e-78 261.4 0.0 9.3e-78 260.9 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EFX01356.1 - 3e-34 116.5 0.8 7.8e-34 115.2 0.1 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EFX01356.1 - 1.9e-30 105.2 0.3 3.8e-30 104.2 0.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EFX01356.1 - 3.4e-16 58.5 6.5 6.8e-16 57.5 4.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EFX01356.1 - 2.9e-15 55.7 0.0 1.3e-14 53.6 0.0 2.1 2 0 0 2 2 2 1 Gelsolin repeat DUF3115 PF11312.3 EFX01357.1 - 6.6e-58 196.0 0.0 1.5e-32 112.6 0.0 3.1 2 1 1 3 3 3 3 Protein of unknown function (DUF3115) MAPEG PF01124.13 EFX01358.1 - 1.7e-20 72.9 1.5 2e-20 72.7 1.1 1.1 1 0 0 1 1 1 1 MAPEG family Ribosomal_L22 PF00237.14 EFX01359.1 - 5.1e-35 119.5 0.1 7.1e-35 119.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e RepB-RCR_reg PF10723.4 EFX01359.1 - 0.11 12.2 1.4 0.25 11.0 0.1 2.2 2 1 1 3 3 3 0 Replication regulatory protein RepB Ribosomal_S3Ae PF01015.13 EFX01360.1 - 1.1e-82 276.1 5.3 1.4e-82 275.7 3.7 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Ras PF00071.17 EFX01360.1 - 1e-27 96.5 0.0 8.6e-20 70.7 0.0 2.6 1 1 1 2 2 2 2 Ras family Miro PF08477.8 EFX01360.1 - 1.1e-06 29.1 0.0 0.00013 22.4 0.0 2.8 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX01360.1 - 0.00043 19.5 0.0 0.02 14.1 0.0 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFX01360.1 - 0.0022 17.9 0.0 0.0081 16.1 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase AAA_14 PF13173.1 EFX01360.1 - 0.0039 17.0 0.0 0.083 12.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX01360.1 - 0.013 15.6 1.9 0.1 12.7 0.0 2.8 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.1 EFX01360.1 - 0.015 15.3 0.1 0.054 13.4 0.0 2.0 3 0 0 3 3 3 0 AAA ATPase domain Arch_ATPase PF01637.13 EFX01360.1 - 0.028 14.1 0.1 0.16 11.6 0.0 2.2 2 1 1 3 3 3 0 Archaeal ATPase AAA_10 PF12846.2 EFX01360.1 - 0.032 13.6 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Syntaxin PF00804.20 EFX01360.1 - 0.22 11.7 1.6 0.4 10.8 0.0 2.1 2 1 1 3 3 2 0 Syntaxin POT1 PF02765.12 EFX01361.1 - 2.1e-07 30.9 0.0 3.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 WD40 PF00400.27 EFX01362.1 - 3.6e-34 115.4 10.3 1.2e-06 28.1 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EFX01362.1 - 6.1e-07 29.3 0.1 0.0092 15.7 0.0 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A RabGAP-TBC PF00566.13 EFX01363.1 - 1.1e-45 155.6 0.0 4.7e-45 153.6 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain UPRTase PF14681.1 EFX01364.1 - 9e-79 263.4 0.0 1.1e-78 263.2 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EFX01364.1 - 0.00048 19.8 0.0 0.00072 19.2 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 EFX01364.1 - 0.12 12.1 0.2 0.19 11.4 0.1 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) 2OG-FeII_Oxy PF03171.15 EFX01365.1 - 0.00037 20.7 0.0 0.0014 18.9 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.9 EFX01367.1 - 9.9e-107 356.0 0.0 1.2e-106 355.8 0.0 1.0 1 0 0 1 1 1 1 Anp1 Zn_clus PF00172.13 EFX01369.1 - 0.006 16.4 12.3 0.006 16.4 8.5 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.5 EFX01369.1 - 0.023 13.9 0.0 0.023 13.9 0.0 2.8 3 0 0 3 3 3 0 Histone chaperone domain CHZ Sds3 PF08598.6 EFX01370.1 - 0.021 14.3 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Sds3-like DUF3962 PF13111.1 EFX01370.1 - 0.047 13.0 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3962) Aminotran_4 PF01063.14 EFX01371.1 - 7.9e-31 107.3 0.0 1.1e-30 106.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV DUF1707 PF08044.6 EFX01371.1 - 0.21 11.3 2.4 0.36 10.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) Aldose_epim PF01263.15 EFX01372.1 - 2.7e-51 174.4 0.0 3.7e-51 174.0 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Bacteriocin_IIi PF11758.3 EFX01372.1 - 0.32 10.6 1.6 0.61 9.7 1.1 1.4 1 0 0 1 1 1 0 Aureocin-like type II bacteriocin Cation_efflux PF01545.16 EFX01373.1 - 8.1e-32 110.4 7.5 1e-31 110.1 5.2 1.1 1 0 0 1 1 1 1 Cation efflux family ABC_tran PF00005.22 EFX01374.1 - 2.8e-45 153.9 0.0 3.7e-21 75.8 0.0 3.1 3 1 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 EFX01374.1 - 7.1e-21 73.8 5.8 7.1e-21 73.8 4.0 3.9 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.1 EFX01374.1 - 8.6e-17 62.0 0.0 0.00014 21.9 0.0 4.5 3 1 1 4 4 4 3 AAA domain SMC_N PF02463.14 EFX01374.1 - 3.6e-11 42.7 0.2 0.0083 15.3 0.0 4.4 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFX01374.1 - 2.3e-09 38.0 0.9 0.0014 19.4 0.0 3.3 3 1 0 3 3 2 2 AAA domain AAA_23 PF13476.1 EFX01374.1 - 2.8e-07 31.0 5.0 0.045 14.0 0.0 4.2 4 0 0 4 4 4 2 AAA domain AAA_29 PF13555.1 EFX01374.1 - 1.5e-06 27.6 0.0 0.019 14.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 EFX01374.1 - 5.4e-06 25.7 0.5 0.16 11.0 0.0 4.1 4 1 0 5 5 5 1 AAA ATPase domain MMR_HSR1 PF01926.18 EFX01374.1 - 6.3e-06 26.1 0.0 0.018 14.9 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 EFX01374.1 - 2.2e-05 24.9 0.0 0.089 13.2 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein DUF258 PF03193.11 EFX01374.1 - 3.5e-05 23.0 0.0 0.03 13.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_33 PF13671.1 EFX01374.1 - 3.7e-05 23.6 0.0 0.23 11.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX01374.1 - 4.4e-05 23.5 4.0 0.0062 16.5 0.1 3.2 4 0 0 4 4 2 1 AAA ATPase domain MobB PF03205.9 EFX01374.1 - 6e-05 22.7 0.1 0.15 11.7 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EFX01374.1 - 0.00011 22.4 4.2 0.14 12.5 0.0 3.2 4 0 0 4 4 2 2 AAA domain AAA_22 PF13401.1 EFX01374.1 - 0.00014 21.9 0.1 0.67 10.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EFX01374.1 - 0.00046 19.7 0.4 5.5 6.3 0.0 3.9 4 0 0 4 4 4 0 AAA-like domain AAA PF00004.24 EFX01374.1 - 0.00065 19.8 0.0 1.5 9.0 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 EFX01374.1 - 0.0011 17.8 0.2 0.54 8.9 0.0 2.6 2 0 0 2 2 2 2 ArgK protein Dynamin_N PF00350.18 EFX01374.1 - 0.0014 18.4 4.3 5 6.9 0.0 4.1 2 1 0 2 2 2 0 Dynamin family AAA_28 PF13521.1 EFX01374.1 - 0.0019 18.2 3.6 0.59 10.0 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.1 EFX01374.1 - 0.0025 17.7 0.1 2.7 7.9 0.0 3.5 4 0 0 4 4 3 1 AAA domain SbcCD_C PF13558.1 EFX01374.1 - 0.0027 17.5 0.6 1.4 8.8 0.2 3.5 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit cobW PF02492.14 EFX01374.1 - 0.0028 17.1 0.4 2 7.7 0.0 2.6 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 EFX01374.1 - 0.007 16.0 0.1 1.4 8.6 0.1 2.7 2 0 0 2 2 2 1 NTPase NACHT PF05729.7 EFX01374.1 - 0.0081 15.8 0.2 2.8 7.5 0.0 2.6 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.17 EFX01374.1 - 0.011 15.8 0.0 4.5 7.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.9 EFX01374.1 - 0.021 14.5 0.2 5.5 6.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.20 EFX01374.1 - 0.031 13.7 0.0 1.7 8.1 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.1 EFX01374.1 - 0.032 13.6 0.1 9.5 5.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain GTP_EFTU PF00009.22 EFX01374.1 - 0.088 12.2 0.1 17 4.7 0.0 2.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 EFX01374.1 - 0.095 12.1 0.0 11 5.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 EFX01374.1 - 0.12 11.6 0.0 16 4.7 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.12 EFX01374.1 - 0.13 11.7 0.0 19 4.7 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Proteasome PF00227.21 EFX01375.1 - 4.7e-53 179.3 0.2 7.6e-53 178.6 0.1 1.3 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFX01375.1 - 1.3e-13 49.9 0.9 2.3e-13 49.1 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF3137 PF11335.3 EFX01375.1 - 0.14 11.8 0.0 0.65 9.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3137) HET PF06985.6 EFX01376.1 - 6.2e-22 78.2 0.0 1.1e-21 77.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Isochorismatase PF00857.15 EFX01377.1 - 1.2e-32 113.2 0.4 2.8e-22 79.4 0.0 2.0 2 0 0 2 2 2 2 Isochorismatase family Pkinase PF00069.20 EFX01379.1 - 9.8e-63 211.7 0.0 1.2e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01379.1 - 3e-35 121.5 0.0 3.8e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX01379.1 - 3.6e-06 26.1 0.0 6.8e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX01379.1 - 0.0052 15.8 0.1 0.0091 15.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRV PF01816.12 EFX01379.1 - 0.3 11.3 2.7 4.7 7.6 0.1 3.9 3 0 0 3 3 3 0 Leucine rich repeat variant Band_7 PF01145.20 EFX01380.1 - 1.2e-23 83.9 7.5 1.3e-23 83.8 4.0 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family DUF2884 PF11101.3 EFX01380.1 - 0.0093 15.3 0.8 0.017 14.5 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2884) Ribonuc_L-PSP PF01042.16 EFX01381.1 - 1.3e-38 131.4 0.1 1.4e-38 131.3 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Syja_N PF02383.13 EFX01383.1 - 3.5e-96 321.7 0.0 5.3e-96 321.1 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.3 EFX01383.1 - 7.3e-34 115.6 0.0 1.8e-33 114.3 0.0 1.7 2 0 0 2 2 2 1 Inositol phosphatase Phage_T4_Ndd PF06591.6 EFX01383.1 - 0.064 12.8 0.0 5.2 6.6 0.0 2.4 2 0 0 2 2 2 0 T4-like phage nuclear disruption protein (Ndd) UcrQ PF02939.11 EFX01384.1 - 1.4e-27 95.3 0.2 1.7e-27 95.0 0.1 1.1 1 0 0 1 1 1 1 UcrQ family Flavoprotein PF02441.14 EFX01385.1 - 2.4e-17 62.8 0.0 4.8e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Flavoprotein DUF544 PF04424.8 EFX01385.1 - 0.24 11.1 0.0 0.44 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF544) F-box-like PF12937.2 EFX01385.1 - 0.4 10.4 0.0 0.4 10.4 0.0 2.9 3 0 0 3 3 3 0 F-box-like STAG PF08514.6 EFX01386.1 - 2e-27 95.2 0.2 4.6e-27 94.0 0.1 1.6 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.1 EFX01386.1 - 1.7e-06 28.1 1.5 2e-05 24.7 0.0 3.5 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 EFX01386.1 - 0.012 15.5 0.0 14 6.0 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat Vfa1 PF08432.5 EFX01386.1 - 4.6 7.2 17.3 3.6 7.5 0.3 3.4 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 DUF1223 PF06764.6 EFX01387.1 - 1.1e-38 133.0 0.1 2e-26 93.1 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1223) Thioredoxin_3 PF13192.1 EFX01387.1 - 0.085 12.6 0.0 14 5.5 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain Tyrosinase PF00264.15 EFX01388.1 - 1.6e-35 123.3 0.0 2.6e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase CENP-S PF15630.1 EFX01389.1 - 1.9e-32 111.2 0.0 2.4e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 EFX01389.1 - 0.0078 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T PF15511.1 EFX01389.1 - 0.027 13.7 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TFIID-18kDa PF02269.11 EFX01389.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.7 1 1 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit SHNi-TPR PF10516.4 EFX01390.1 - 3.9e-14 51.5 1.4 8.6e-14 50.5 0.1 2.2 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.1 EFX01390.1 - 5.2e-10 39.1 3.5 1.1e-05 25.2 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX01390.1 - 1.3e-06 27.9 2.9 4.3e-05 23.0 0.3 2.6 2 0 0 2 2 2 1 TPR repeat SNAP PF14938.1 EFX01390.1 - 2.5e-05 23.5 1.1 7.8e-05 21.9 0.7 1.8 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_16 PF13432.1 EFX01390.1 - 0.00014 22.3 0.6 0.00014 22.3 0.4 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX01390.1 - 0.00045 20.4 0.2 0.0015 18.7 0.2 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 EFX01390.1 - 0.0036 17.3 0.5 0.19 11.9 0.1 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 EFX01390.1 - 0.0072 16.0 0.4 0.0072 16.0 0.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 EFX01390.1 - 0.023 14.4 1.9 0.057 13.2 1.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.1 EFX01390.1 - 0.024 14.8 0.2 1.2 9.5 0.0 3.4 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFX01390.1 - 0.04 13.8 0.4 0.04 13.8 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFX01390.1 - 0.061 12.9 3.6 0.16 11.6 2.3 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat PA_decarbox PF05870.6 EFX01390.1 - 0.14 11.6 0.0 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) TPR_14 PF13428.1 EFX01390.1 - 0.83 10.4 5.6 0.3 11.8 0.4 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFX01390.1 - 1.1 9.1 4.6 1.3 9.0 1.1 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFX01390.1 - 2 8.5 14.3 0.074 13.0 2.8 3.7 5 0 0 5 5 4 0 Tetratricopeptide repeat RNase_T PF00929.19 EFX01391.1 - 4.2e-06 27.1 0.0 2.1e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Exonuclease CHORD PF04968.7 EFX01391.1 - 1 9.6 4.2 5.7 7.2 1.3 2.8 1 1 1 2 2 2 0 CHORD RNA_pol_Rpc4 PF05132.9 EFX01393.1 - 1.5e-17 63.7 0.0 1.5e-17 63.7 0.0 3.4 2 1 2 4 4 4 1 RNA polymerase III RPC4 Pkinase PF00069.20 EFX01394.1 - 4.6e-43 147.2 0.0 2.1e-42 145.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01394.1 - 6.7e-24 84.3 0.0 2.9e-17 62.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase AMP-binding PF00501.23 EFX01395.1 - 2.7e-78 263.2 0.4 2.7e-78 263.2 0.3 1.7 2 0 0 2 2 2 1 AMP-binding enzyme UCH PF00443.24 EFX01395.1 - 7.9e-33 113.7 0.0 9.5e-30 103.6 0.0 3.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX01395.1 - 1.3e-14 54.3 2.6 9.4e-14 51.5 0.0 2.7 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 EFX01395.1 - 0.00034 20.9 0.0 0.00092 19.5 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Thioredoxin PF00085.15 EFX01396.1 - 7.2e-62 205.5 0.1 7.7e-30 102.6 0.0 2.5 3 0 0 3 3 3 2 Thioredoxin ERp29 PF07749.7 EFX01396.1 - 2e-24 85.9 2.3 9.2e-24 83.9 0.4 2.3 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.1 EFX01396.1 - 5.2e-20 71.7 1.0 3.3e-08 33.6 0.0 3.8 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 EFX01396.1 - 7.3e-15 54.7 0.0 2.8e-06 27.2 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 EFX01396.1 - 4.9e-14 52.2 0.1 1.6e-05 24.9 0.0 3.5 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.16 EFX01396.1 - 3.2e-09 36.5 0.1 0.00057 19.5 0.0 2.6 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 EFX01396.1 - 2e-06 27.3 0.3 0.044 13.3 0.0 3.1 3 0 0 3 3 3 2 Redoxin Thioredoxin_4 PF13462.1 EFX01396.1 - 4.8e-06 26.6 1.8 1.8 8.5 0.0 4.7 3 2 2 5 5 5 2 Thioredoxin Thioredoxin_6 PF13848.1 EFX01396.1 - 5.3e-06 26.3 1.6 0.2 11.4 0.0 3.6 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EFX01396.1 - 5e-05 22.8 0.0 0.031 13.8 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin ERp29_N PF07912.8 EFX01396.1 - 0.0001 22.2 0.0 0.0011 18.8 0.0 2.3 2 1 0 2 2 2 1 ERp29, N-terminal domain HyaE PF07449.6 EFX01396.1 - 0.0011 18.7 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TraF PF13728.1 EFX01396.1 - 0.002 17.6 0.0 0.32 10.4 0.0 3.0 3 0 0 3 3 3 1 F plasmid transfer operon protein Glutaredoxin PF00462.19 EFX01396.1 - 0.0045 16.9 0.2 6.1 6.9 0.0 3.0 2 1 0 2 2 2 2 Glutaredoxin DDE_Tnp_1_2 PF13586.1 EFX01396.1 - 0.03 14.5 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 Transposase DDE domain BssS PF13991.1 EFX01396.1 - 0.056 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 BssS protein family AF0941-like PF14591.1 EFX01396.1 - 0.091 12.8 0.6 0.18 11.8 0.3 1.5 1 1 0 1 1 1 0 AF0941-like YqeY PF09424.5 EFX01397.1 - 2.3e-19 69.6 1.6 3.2e-19 69.1 1.1 1.2 1 0 0 1 1 1 1 Yqey-like protein DUF4194 PF13835.1 EFX01397.1 - 0.052 12.9 1.0 0.14 11.6 0.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4194) DUF3812 PF12757.2 EFX01398.1 - 9.8e-35 119.2 13.5 9.8e-35 119.2 9.3 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF3812) A_deaminase PF00962.17 EFX01399.1 - 8e-42 143.3 0.0 1.6e-33 116.0 0.0 2.2 2 0 0 2 2 2 2 Adenosine/AMP deaminase AIF_C PF14721.1 EFX01399.1 - 0.022 14.9 1.0 0.046 13.9 0.7 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Vfa1 PF08432.5 EFX01399.1 - 0.083 12.9 11.8 0.17 11.9 8.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TAF4 PF05236.9 EFX01399.1 - 0.095 11.9 7.0 0.15 11.3 4.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family U79_P34 PF03064.11 EFX01399.1 - 0.17 11.3 10.3 0.28 10.6 7.2 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF1510 PF07423.6 EFX01399.1 - 0.46 9.8 14.1 0.8 9.0 9.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 EFX01399.1 - 1.5 6.7 9.9 2.3 6.1 6.9 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.1 EFX01399.1 - 3.1 7.4 5.1 6.1 6.5 3.6 1.4 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.11 EFX01399.1 - 3.7 6.4 7.0 7.3 5.4 4.9 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.4 EFX01399.1 - 3.9 6.1 18.7 6.1 5.4 13.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MFS_1 PF07690.11 EFX01400.1 - 5.7e-39 133.8 49.0 9.1e-39 133.1 34.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX01400.1 - 9.4e-13 47.2 27.0 1.3e-12 46.7 18.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) EF-hand_1 PF00036.27 EFX01401.1 - 4.4e-27 91.2 13.1 1e-06 27.5 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 EFX01401.1 - 4.7e-24 84.3 2.7 3.4e-12 46.3 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EFX01401.1 - 4.2e-20 69.7 5.9 0.00011 21.7 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 EFX01401.1 - 2.5e-19 67.6 11.9 6.1e-06 25.3 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 EFX01401.1 - 1.7e-15 56.3 12.6 2.1e-05 24.0 0.8 4.6 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 EFX01401.1 - 3.8e-07 30.1 0.0 0.00044 20.2 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 EFX01401.1 - 4.1e-06 26.4 6.6 0.01 15.5 0.3 3.7 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 EFX01401.1 - 0.0099 15.7 0.1 0.52 10.2 0.1 2.9 2 1 1 3 3 3 1 EF-hand domain Aldolase_II PF00596.16 EFX01402.1 - 3.5e-48 163.6 1.7 5.2e-48 163.0 1.2 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain TB2_DP1_HVA22 PF03134.14 EFX01403.1 - 1.2e-30 105.0 5.3 1.8e-30 104.5 3.7 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Bestrophin PF01062.16 EFX01403.1 - 0.063 12.2 7.1 0.13 11.1 4.9 1.5 1 1 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel DUF2583 PF10762.4 EFX01403.1 - 0.49 10.5 2.1 1.1 9.3 1.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2583) WD40 PF00400.27 EFX01404.1 - 4.9e-19 67.4 6.5 1.3e-05 24.8 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat PQQ PF01011.16 EFX01404.1 - 0.0004 19.7 0.1 1.7 8.3 0.0 3.5 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_3 PF13570.1 EFX01404.1 - 3.2 8.1 16.5 5 7.5 0.4 6.0 5 1 1 6 6 6 0 PQQ-like domain FMO-like PF00743.14 EFX01406.1 - 7.1e-26 90.4 0.0 1.3e-14 53.3 0.0 3.7 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFX01406.1 - 6.3e-15 55.7 1.3 1.7e-13 51.1 0.9 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX01406.1 - 4.1e-09 36.6 0.0 0.00023 21.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX01406.1 - 7.8e-08 32.2 3.4 5.5e-07 29.4 0.2 3.0 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFX01406.1 - 1.4e-07 31.4 0.0 3.6e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX01406.1 - 3.4e-06 26.2 0.4 6.5e-05 21.9 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 EFX01406.1 - 3e-05 23.2 0.3 0.0003 19.9 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 EFX01406.1 - 0.003 16.6 0.1 0.0053 15.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.19 EFX01406.1 - 0.0047 15.8 1.6 0.008 15.0 0.4 1.8 2 0 0 2 2 2 1 FAD binding domain IlvN PF07991.7 EFX01406.1 - 0.0052 16.1 0.1 0.011 15.1 0.0 1.5 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain DAO PF01266.19 EFX01406.1 - 0.035 12.9 3.3 0.57 9.0 0.3 3.0 2 1 1 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX01406.1 - 0.036 12.5 0.4 0.077 11.4 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.2 EFX01406.1 - 0.099 11.6 0.1 0.17 10.8 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.14 EFX01407.1 - 1.4e-52 177.3 0.0 2.2e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX01407.1 - 1.4e-33 115.1 0.0 1.9e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFX01407.1 - 8.5e-06 25.7 0.4 1.9e-05 24.5 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 EFX01407.1 - 0.0031 17.3 0.1 0.0096 15.7 0.0 1.7 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.20 EFX01407.1 - 0.0091 15.4 0.7 0.041 13.3 0.1 2.4 2 1 0 2 2 2 1 ACT domain IlvN PF07991.7 EFX01407.1 - 0.1 11.9 0.1 0.56 9.5 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Lipoxygenase PF00305.14 EFX01408.1 - 8.7e-27 93.4 0.0 1.2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Lipoxygenase DUF1793 PF08760.6 EFX01409.1 - 3.2e-75 251.6 0.0 9.2e-75 250.2 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) UbiD PF01977.11 EFX01410.1 - 5.7e-131 436.7 0.0 6.6e-131 436.5 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AAA_12 PF13087.1 EFX01411.1 - 2.7e-37 128.1 0.0 1.1e-36 126.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 EFX01411.1 - 9.2e-25 87.5 0.0 2e-24 86.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX01411.1 - 3.2e-10 39.6 0.0 2.7e-09 36.6 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain DUF2075 PF09848.4 EFX01411.1 - 2.9e-06 26.5 0.1 0.002 17.2 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) DRMBL PF07522.9 EFX01411.1 - 1.4e-05 25.0 0.0 3.3e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase AAA_30 PF13604.1 EFX01411.1 - 5.7e-05 22.7 0.0 0.0024 17.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.16 EFX01411.1 - 0.0016 17.7 0.0 0.0038 16.5 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.1 EFX01411.1 - 0.0086 16.0 0.5 0.068 13.1 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain ResIII PF04851.10 EFX01411.1 - 0.0091 15.8 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.1 EFX01411.1 - 0.04 14.0 0.0 0.32 11.1 0.0 2.6 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain PhoH PF02562.11 EFX01411.1 - 0.073 12.3 0.1 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Cu-oxidase_2 PF07731.9 EFX01412.1 - 9.4e-47 157.9 7.8 1.5e-40 137.9 0.2 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 EFX01412.1 - 2.3e-41 140.2 6.0 1.3e-39 134.6 1.2 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EFX01412.1 - 8.9e-31 106.9 4.8 7.9e-29 100.6 0.2 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.1 EFX01412.1 - 0.0026 17.6 0.0 1.8 8.5 0.0 3.5 4 0 0 4 4 4 1 Cupredoxin-like domain Spermine_synth PF01564.12 EFX01413.1 - 2.9e-06 26.4 0.0 4.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 EFX01413.1 - 0.00043 20.8 0.0 0.0011 19.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01413.1 - 0.011 15.5 0.1 0.027 14.1 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain zf-C2H2_4 PF13894.1 EFX01414.1 - 0.00075 19.6 17.6 0.13 12.6 0.0 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX01414.1 - 0.035 14.4 24.5 1.6 9.2 0.0 5.1 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EFX01414.1 - 0.092 12.6 4.2 0.13 12.1 0.7 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger DUF629 PF04780.7 EFX01414.1 - 0.21 10.0 0.4 0.56 8.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF629) APG6 PF04111.7 EFX01415.1 - 0.0031 16.6 12.8 0.0047 16.0 8.8 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 DUF874 PF05917.6 EFX01415.1 - 0.077 11.8 16.6 0.12 11.2 11.5 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Borrelia_P83 PF05262.6 EFX01415.1 - 0.66 8.1 17.5 0.96 7.6 12.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein ERM PF00769.14 EFX01415.1 - 1.3 8.5 24.9 0.52 9.8 15.1 1.9 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Atg14 PF10186.4 EFX01415.1 - 2.4 7.0 17.7 4.1 6.2 12.2 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF2361 PF10153.4 EFX01415.1 - 2.7 8.1 15.7 5.5 7.2 10.9 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2361) DDRGK PF09756.4 EFX01415.1 - 4.4 6.6 21.1 7.1 5.9 14.6 1.2 1 0 0 1 1 1 0 DDRGK domain NAP PF00956.13 EFX01416.1 - 2.8e-87 291.8 10.2 2.8e-87 291.8 7.1 2.0 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) DUF947 PF06102.7 EFX01417.1 - 3.4e-42 144.1 12.8 3.4e-42 144.1 8.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF947) WAPL PF07814.8 EFX01418.1 - 1.3e-12 47.1 0.1 1.1e-10 40.7 0.0 2.3 2 0 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin PAXIP1_C PF15364.1 EFX01418.1 - 0.041 13.7 9.9 3.3 7.6 0.2 3.5 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein SCAMP PF04144.8 EFX01418.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 SCAMP family NIF PF03031.13 EFX01419.1 - 9.1e-53 178.1 0.0 1.2e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pyr_redox_2 PF07992.9 EFX01420.1 - 1.2e-05 25.2 0.0 5.9e-05 23.0 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX01420.1 - 0.0006 19.6 0.0 0.016 14.9 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 EFX01420.1 - 0.0024 16.8 0.1 0.018 13.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX01420.1 - 0.0028 17.7 0.0 0.018 15.1 0.1 2.2 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Myosin_N PF02736.14 EFX01420.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain FAD_binding_3 PF01494.14 EFX01420.1 - 0.088 11.8 0.0 0.5 9.3 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain DHDPS PF00701.17 EFX01421.1 - 3e-40 137.6 0.0 7.2e-40 136.4 0.0 1.5 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family CGI-121 PF08617.5 EFX01422.1 - 1e-43 148.8 0.0 1.2e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 UBX PF00789.15 EFX01423.1 - 0.00025 21.0 0.0 0.00056 19.9 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA PF00627.26 EFX01423.1 - 0.0013 18.4 0.1 0.0068 16.2 0.0 2.3 2 0 0 2 2 2 1 UBA/TS-N domain zf-C2H2 PF00096.21 EFX01423.1 - 0.026 14.8 0.1 0.054 13.8 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 EFX01423.1 - 0.035 14.2 0.1 0.075 13.1 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Trm112p PF03966.11 EFX01423.1 - 0.05 13.9 0.2 0.23 11.8 0.0 2.1 2 1 0 2 2 2 0 Trm112p-like protein zf-C2H2_jaz PF12171.3 EFX01423.1 - 0.076 13.1 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.1 EFX01423.1 - 0.12 12.2 7.4 0.089 12.7 3.6 1.8 1 1 1 2 2 2 0 CpXC protein APG6 PF04111.7 EFX01423.1 - 4.9 6.1 20.4 8.8 5.2 14.1 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3455 PF11937.3 EFX01424.1 - 4.7e-46 156.9 2.2 2.3e-45 154.7 1.5 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) Mid1 PF12929.2 EFX01426.1 - 8.3e-127 423.4 10.8 1.1e-126 423.0 7.5 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.17 EFX01426.1 - 0.095 13.0 3.5 0.64 10.3 0.4 2.4 2 0 0 2 2 2 0 Fz domain TBP PF00352.16 EFX01427.1 - 4.8e-69 227.7 0.0 8.5e-35 117.9 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EFX01427.1 - 0.00036 20.5 0.0 0.98 9.5 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Elf1 PF05129.8 EFX01428.1 - 1.8e-29 101.2 0.3 2.2e-29 100.9 0.2 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Zn_Tnp_IS1595 PF12760.2 EFX01428.1 - 0.14 11.9 1.2 0.25 11.2 0.9 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2H2_6 PF13912.1 EFX01428.1 - 0.78 9.7 4.8 0.47 10.4 0.4 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger UCR_hinge PF02320.11 EFX01429.1 - 3.9e-26 90.7 8.2 8.8e-26 89.6 5.7 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Mitofilin PF09731.4 EFX01429.1 - 0.027 13.1 6.6 0.028 13.0 4.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein HSP70 PF00012.15 EFX01429.1 - 0.2 9.5 5.9 0.22 9.3 4.1 1.0 1 0 0 1 1 1 0 Hsp70 protein Sigma70_ner PF04546.8 EFX01429.1 - 0.27 10.8 9.0 0.32 10.5 6.2 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region APG6 PF04111.7 EFX01429.1 - 0.42 9.5 5.7 0.47 9.4 3.9 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2052 PF09747.4 EFX01429.1 - 0.75 9.6 11.1 0.9 9.4 7.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF740 PF05340.7 EFX01429.1 - 0.78 8.0 7.6 0.9 7.8 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) YqfQ PF14181.1 EFX01429.1 - 1.5 8.8 5.0 1.7 8.6 3.5 1.3 1 0 0 1 1 1 0 YqfQ-like protein Asp-B-Hydro_N PF05279.6 EFX01429.1 - 1.9 8.2 15.6 2.3 8.0 10.8 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Ycf1 PF05758.7 EFX01429.1 - 2 6.0 6.5 2.1 5.9 4.5 1.0 1 0 0 1 1 1 0 Ycf1 Daxx PF03344.10 EFX01429.1 - 3.3 6.0 14.1 3.5 5.9 9.8 1.0 1 0 0 1 1 1 0 Daxx Family Pox_Ag35 PF03286.9 EFX01429.1 - 3.7 7.0 8.5 4.2 6.8 5.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF1510 PF07423.6 EFX01429.1 - 5.8 6.2 12.0 6.8 5.9 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDRGK PF09756.4 EFX01429.1 - 6 6.2 13.1 7.6 5.9 9.1 1.1 1 0 0 1 1 1 0 DDRGK domain RR_TM4-6 PF06459.7 EFX01429.1 - 8.7 6.1 14.0 10 5.9 9.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3530 PF12048.3 EFX01429.1 - 9.6 5.0 8.4 10 5.0 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Exo_endo_phos PF03372.18 EFX01430.1 - 2.3e-12 47.3 0.6 2.9e-12 47.0 0.4 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UQ_con PF00179.21 EFX01431.1 - 1.1e-51 173.9 0.0 1.2e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX01431.1 - 0.00023 20.9 0.0 0.00028 20.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFX01431.1 - 0.0075 16.1 0.0 0.0088 15.9 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 EFX01431.1 - 0.057 13.0 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 UEV domain Glyco_hydro_3 PF00933.16 EFX01432.1 - 4.5e-53 180.1 0.0 1.1e-52 178.8 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX01432.1 - 0.0014 18.1 0.0 0.0031 17.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_7 PF13508.1 EFX01432.1 - 0.09 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TRAM_LAG1_CLN8 PF03798.11 EFX01433.1 - 7.3e-47 159.4 8.9 1.1e-46 158.9 6.1 1.3 1 0 0 1 1 1 1 TLC domain DUF676 PF05057.9 EFX01434.1 - 9.3e-51 172.2 0.0 1.4e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 EFX01434.1 - 3.9e-07 30.1 1.4 6.7e-07 29.4 0.9 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX01434.1 - 3.1e-06 27.0 0.1 6.9e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX01434.1 - 0.00035 20.2 0.0 0.00059 19.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 EFX01434.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Pyridox_ox_2 PF12900.2 EFX01436.1 - 5.8e-35 120.2 0.0 8.9e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FYVE PF01363.16 EFX01437.1 - 1.5 8.7 17.0 0.029 14.2 5.6 2.5 2 0 0 2 2 2 0 FYVE zinc finger FYVE_2 PF02318.11 EFX01437.1 - 4 7.3 9.5 3 7.7 2.7 2.8 2 1 0 2 2 2 0 FYVE-type zinc finger WD40 PF00400.27 EFX01438.1 - 5.2e-54 178.2 13.2 1.5e-09 37.3 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EFX01438.1 - 0.0075 15.0 0.0 3.3 6.3 0.0 3.5 2 1 0 3 3 3 1 Nup133 N terminal like Nup160 PF11715.3 EFX01438.1 - 0.01 14.0 3.3 5.1 5.1 0.0 3.9 1 1 2 4 4 4 0 Nucleoporin Nup120/160 PQQ_2 PF13360.1 EFX01438.1 - 0.03 13.7 0.2 9.1 5.6 0.0 2.8 2 1 0 2 2 2 0 PQQ-like domain ApbA_C PF08546.6 EFX01439.1 - 4.3e-27 94.5 0.0 8.2e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFX01439.1 - 1.2e-26 93.0 0.2 1.7e-26 92.4 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.15 EFX01439.1 - 0.11 12.5 0.5 0.31 11.1 0.3 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Methyltransf_23 PF13489.1 EFX01440.1 - 2.8e-10 40.1 0.0 4.1e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX01440.1 - 4.2e-06 27.1 0.0 7.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX01440.1 - 0.024 14.2 0.0 0.054 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 EFX01440.1 - 0.06 13.8 0.0 0.29 11.6 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.7 EFX01440.1 - 0.095 11.9 0.0 0.17 11.1 0.0 1.4 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase AAA PF00004.24 EFX01441.1 - 2.6e-18 66.4 0.0 5.9e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFX01441.1 - 0.0018 18.2 0.2 0.0066 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EFX01441.1 - 0.0019 19.0 0.0 0.0074 17.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX01441.1 - 0.023 14.8 0.2 0.085 12.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFX01441.1 - 0.048 13.3 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EFX01441.1 - 0.073 12.1 0.2 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EFX01441.1 - 0.083 12.7 0.5 0.22 11.3 0.1 1.9 2 0 0 2 2 2 0 AAA domain CPT PF07931.7 EFX01441.1 - 0.099 12.2 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Pro_dh PF01619.13 EFX01442.1 - 1.2e-35 123.0 0.0 1.5e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase HLH PF00010.21 EFX01443.1 - 2.7e-17 62.1 0.0 5.9e-17 61.1 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tropomyosin PF00261.15 EFX01443.1 - 0.03 13.3 0.9 0.059 12.4 0.6 1.4 1 0 0 1 1 1 0 Tropomyosin ABC_tran PF00005.22 EFX01444.1 - 6.5e-16 58.8 0.0 2.4e-15 57.0 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EFX01444.1 - 5.1e-08 33.2 0.0 0.00087 19.3 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX01444.1 - 0.00072 19.0 0.1 0.0017 17.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3584 PF12128.3 EFX01444.1 - 0.0014 16.0 0.6 0.0019 15.6 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_25 PF13481.1 EFX01444.1 - 0.0018 17.7 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX01444.1 - 0.0024 17.8 0.1 0.0048 16.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.1 EFX01444.1 - 0.015 15.5 0.1 0.022 15.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFX01444.1 - 0.016 14.4 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFX01444.1 - 0.016 16.0 0.4 0.046 14.5 0.2 1.9 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.14 EFX01444.1 - 0.02 14.0 0.0 3.1 6.9 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PduV-EutP PF10662.4 EFX01444.1 - 0.027 13.9 0.1 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 EFX01444.1 - 0.033 14.1 0.2 0.075 12.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 EFX01444.1 - 0.052 12.9 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_15 PF13175.1 EFX01444.1 - 0.057 12.4 0.0 0.47 9.4 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.2 EFX01444.1 - 0.062 12.7 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain NACHT PF05729.7 EFX01444.1 - 0.11 12.1 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.1 EFX01444.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain Arf PF00025.16 EFX01444.1 - 0.11 11.6 0.2 0.33 10.1 0.0 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family cobW PF02492.14 EFX01444.1 - 0.12 11.8 0.2 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.18 EFX01444.1 - 0.14 11.9 0.1 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA PF00004.24 EFX01444.1 - 0.15 12.2 0.1 0.4 10.8 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EFX01444.1 - 0.21 10.6 0.4 0.34 9.9 0.3 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_13 PF13166.1 EFX01444.1 - 0.25 9.7 0.1 0.34 9.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain TRAP_alpha PF03896.11 EFX01445.1 - 1.4e-05 24.2 0.1 0.0002 20.4 0.1 2.4 2 1 0 2 2 2 1 Translocon-associated protein (TRAP), alpha subunit GST_N_3 PF13417.1 EFX01446.1 - 9.1e-13 48.2 0.0 1.8e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain zf-CCHC PF00098.18 EFX01446.1 - 7.1e-11 41.5 12.7 1.2e-05 24.9 0.4 2.8 3 0 0 3 3 3 2 Zinc knuckle GST_N_2 PF13409.1 EFX01446.1 - 7.1e-10 38.7 0.0 1.6e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain KH_1 PF00013.24 EFX01446.1 - 4e-09 35.9 0.1 7.9e-09 35.0 0.1 1.5 1 0 0 1 1 1 1 KH domain GST_N PF02798.15 EFX01446.1 - 4.3e-09 36.4 0.0 7.8e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain KH_3 PF13014.1 EFX01446.1 - 6.8e-06 25.6 0.2 1.6e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.1 EFX01446.1 - 3.4e-05 23.4 7.2 0.0019 17.8 2.4 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.1 EFX01446.1 - 0.0028 17.2 8.2 0.12 12.0 0.4 2.7 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 EFX01446.1 - 0.0034 17.0 5.9 0.42 10.3 0.5 2.4 2 0 0 2 2 2 2 Zinc knuckle Glyco_hydro_16 PF00722.16 EFX01447.1 - 1.7e-42 144.7 3.9 1.7e-42 144.7 2.7 2.2 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 KH_2 PF07650.12 EFX01448.1 - 0.064 12.8 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 KH domain Glyco_hydro_47 PF01532.15 EFX01449.1 - 2.6e-160 533.9 0.3 3.3e-160 533.6 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CMD PF02627.15 EFX01450.1 - 0.0013 18.4 0.4 0.0057 16.4 0.0 2.1 2 1 0 2 2 2 1 Carboxymuconolactone decarboxylase family HNH_2 PF13391.1 EFX01451.1 - 8.2e-08 31.9 0.1 1.5e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Peptidase_S3 PF00944.14 EFX01451.1 - 0.12 11.7 0.1 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein Peptidase_S32 PF05579.8 EFX01451.1 - 0.14 11.1 0.1 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 LCCL PF03815.14 EFX01452.1 - 2.8e-17 62.4 0.1 4.6e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Fungal_trans_2 PF11951.3 EFX01453.1 - 2.5e-19 69.1 0.1 3.8e-15 55.3 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Fungal_trans PF04082.13 EFX01453.1 - 0.00068 18.5 0.7 0.0026 16.6 0.2 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain GATase_5 PF13507.1 EFX01454.1 - 1.4e-90 302.7 0.0 2.1e-90 302.1 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 EFX01454.1 - 7.3e-39 133.2 2.3 1e-20 74.3 0.2 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 EFX01454.1 - 5.4e-20 71.4 0.6 5e-19 68.3 0.0 2.8 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain DUF1479 PF07350.7 EFX01455.1 - 1.2e-06 27.2 0.0 1.5e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Abhydrolase_3 PF07859.8 EFX01457.1 - 2.1e-17 63.4 0.0 4.3e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX01457.1 - 5.9e-11 42.3 0.0 9.9e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX01457.1 - 6.7e-10 38.5 0.0 1.3e-07 31.0 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFX01457.1 - 5.1e-08 33.0 0.2 8.2e-08 32.4 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX01457.1 - 0.00015 21.3 0.0 0.0028 17.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.7 EFX01457.1 - 0.00024 19.7 0.0 0.032 12.7 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Esterase PF00756.15 EFX01457.1 - 0.00052 19.5 0.0 0.00077 18.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 EFX01457.1 - 0.0018 17.7 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.13 EFX01457.1 - 0.0041 16.5 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) COesterase PF00135.23 EFX01457.1 - 0.032 12.9 0.2 0.084 11.5 0.0 1.6 2 0 0 2 2 2 0 Carboxylesterase family Peptidase_S28 PF05577.7 EFX01457.1 - 0.036 12.6 0.0 0.051 12.1 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Esterase_phd PF10503.4 EFX01457.1 - 0.037 13.2 0.2 0.52 9.5 0.0 2.2 1 1 1 2 2 2 0 Esterase PHB depolymerase DLH PF01738.13 EFX01457.1 - 0.12 11.5 0.0 7.5 5.7 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Chlorophyllase2 PF12740.2 EFX01457.1 - 0.13 11.1 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme LIP PF03583.9 EFX01457.1 - 0.13 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Secretory lipase Ribosomal_L31 PF01197.13 EFX01458.1 - 0.00029 20.7 0.0 0.00049 20.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 HET PF06985.6 EFX01460.1 - 2.5e-16 60.0 0.0 2.7e-15 56.7 0.0 2.4 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NUC153 PF08159.7 EFX01460.1 - 1.7e-12 46.7 1.4 3.4e-12 45.7 1.0 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.27 EFX01460.1 - 7.5e-05 22.4 0.2 0.0058 16.4 0.0 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat NmrA PF05368.8 EFX01462.1 - 2e-24 86.1 0.0 2.3e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX01462.1 - 7.5e-15 55.4 0.6 1.1e-14 54.8 0.3 1.5 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 EFX01462.1 - 5.1e-06 25.7 0.3 8.8e-06 24.9 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 EFX01462.1 - 3.1e-05 23.5 0.2 9.7e-05 21.9 0.1 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFX01462.1 - 0.0078 14.9 0.0 0.02 13.6 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 EFX01462.1 - 0.013 15.4 0.5 0.013 15.4 0.4 1.8 2 0 0 2 2 2 0 short chain dehydrogenase XdhC_C PF13478.1 EFX01462.1 - 0.02 15.1 0.1 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain DFP PF04127.10 EFX01462.1 - 0.025 14.2 1.0 0.03 13.9 0.2 1.4 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein NAD_binding_2 PF03446.10 EFX01462.1 - 0.045 13.6 0.1 0.087 12.6 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_transf_28 PF03033.15 EFX01462.1 - 0.047 13.4 0.1 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain F420_oxidored PF03807.12 EFX01462.1 - 0.1 13.0 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HSP90 PF00183.13 EFX01463.1 - 1.8e-254 845.0 32.6 2.2e-254 844.8 22.6 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 EFX01463.1 - 6e-12 45.2 0.1 1.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFX01463.1 - 1.8e-11 43.8 0.2 1.8e-11 43.8 0.2 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.4 EFX01463.1 - 0.03 14.1 2.1 0.036 13.8 0.1 2.1 2 0 0 2 2 2 0 Tumour suppressor protein zf-rbx1 PF12678.2 EFX01464.1 - 3.7e-10 39.7 1.0 7.4e-10 38.8 0.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 EFX01464.1 - 1e-07 31.6 10.8 5.9e-07 29.2 7.5 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFX01464.1 - 1.7e-06 27.6 1.6 2.7e-06 26.9 1.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX01464.1 - 5.8e-06 25.9 1.6 1.1e-05 25.0 1.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFX01464.1 - 6e-05 22.9 1.7 6e-05 22.9 1.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX01464.1 - 8.1e-05 22.2 4.3 0.00019 21.0 3.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2921 PF11145.3 EFX01464.1 - 0.0047 14.7 0.1 0.0065 14.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2921) zf-Apc11 PF12861.2 EFX01464.1 - 0.0095 15.7 0.9 0.026 14.3 0.6 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 EFX01464.1 - 0.026 14.2 1.7 0.038 13.7 0.4 1.8 1 1 0 1 1 1 0 RING-type zinc-finger TMEM190 PF15431.1 EFX01464.1 - 0.073 13.0 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 190 FANCL_C PF11793.3 EFX01464.1 - 8.2 6.4 5.9 30 4.6 4.1 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain SRP40_C PF05022.7 EFX01465.1 - 7.5e-24 84.0 2.3 7.5e-24 84.0 1.6 2.4 3 0 0 3 3 3 1 SRP40, C-terminal domain Drf_GBD PF06371.8 EFX01466.1 - 2.4e-13 49.8 0.0 2.1e-07 30.4 0.0 2.2 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain DUF2514 PF10721.4 EFX01466.1 - 0.18 11.5 8.3 0.4 10.3 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Myosin_tail_1 PF01576.14 EFX01467.1 - 0.00028 18.8 31.8 0.00028 18.8 22.1 4.1 3 1 2 5 5 5 1 Myosin tail ATG16 PF08614.6 EFX01467.1 - 0.0007 19.4 10.5 0.0007 19.4 7.3 4.7 2 1 2 4 4 4 2 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 EFX01467.1 - 0.002 17.3 12.2 0.2 10.8 2.7 2.6 1 1 2 3 3 3 3 Reovirus sigma C capsid protein FlaC_arch PF05377.6 EFX01467.1 - 0.0074 16.1 30.0 1.2 9.1 0.6 7.1 8 0 0 8 8 8 3 Flagella accessory protein C (FlaC) GAS PF13851.1 EFX01467.1 - 0.0083 15.3 1.1 0.0083 15.3 0.8 5.1 2 1 3 5 5 5 2 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.7 EFX01467.1 - 0.14 12.4 5.8 10 6.4 0.1 4.0 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Filament PF00038.16 EFX01467.1 - 0.33 10.3 44.9 0.083 12.3 18.6 4.2 2 1 0 3 3 3 0 Intermediate filament protein SlyX PF04102.7 EFX01467.1 - 3.1 8.2 0.0 3.1 8.2 0.0 7.0 4 2 2 7 7 7 0 SlyX DUF1664 PF07889.7 EFX01467.1 - 5.7 6.7 15.8 0.87 9.3 1.9 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) PS_Dcarbxylase PF02666.10 EFX01468.1 - 3.8e-79 264.6 0.0 5.1e-78 261.0 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Complex1_51K PF01512.12 EFX01469.1 - 1.3e-47 161.2 0.0 2e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 EFX01469.1 - 3.3e-17 61.3 1.0 3.3e-17 61.3 0.7 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 EFX01469.1 - 3.6e-09 36.3 0.0 7.6e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 SLBB domain Adaptin_N PF01602.15 EFX01470.1 - 1.4e-79 267.8 1.0 1.7e-78 264.2 0.7 2.1 1 1 0 1 1 1 1 Adaptin N terminal region Peptidase_S10 PF00450.17 EFX01471.1 - 3.8e-62 210.7 0.0 6e-62 210.1 0.0 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase ARID PF01388.16 EFX01472.1 - 8.4e-18 64.0 0.0 1.9e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain TGT PF01702.13 EFX01473.1 - 1.6e-25 89.8 0.0 8.4e-25 87.4 0.0 1.9 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.11 EFX01474.1 - 1.1e-36 126.3 62.1 6.5e-32 110.6 38.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Methyltransf_12 PF08242.7 EFX01475.1 - 8.1e-13 48.6 0.0 1.6e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX01475.1 - 6.4e-10 39.2 0.0 1.2e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01475.1 - 7.5e-10 38.7 0.0 1.4e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX01475.1 - 2.6e-09 37.4 0.0 5.5e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01475.1 - 1.6e-08 35.0 0.0 3.3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX01475.1 - 6.9e-08 32.2 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX01475.1 - 0.00014 21.8 0.1 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF3419 PF11899.3 EFX01475.1 - 0.0022 16.7 0.0 0.044 12.4 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3419) MTS PF05175.9 EFX01475.1 - 0.0034 16.7 0.0 0.0074 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.1 EFX01475.1 - 0.0036 18.0 0.0 0.0089 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Acetyltransf_1 PF00583.19 EFX01476.1 - 1e-16 60.7 0.0 1.3e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX01476.1 - 7.4e-07 29.2 0.0 1.4e-06 28.3 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX01476.1 - 1.8e-05 24.4 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EFX01476.1 - 0.00015 21.9 0.0 0.00021 21.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFX01476.1 - 0.00025 21.0 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFX01476.1 - 0.0011 18.9 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX01476.1 - 0.0011 18.8 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Polyketide_cyc PF03364.15 EFX01477.1 - 2.7e-24 85.6 0.0 8.3e-24 84.0 0.0 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 EFX01477.1 - 0.021 14.9 4.1 0.41 10.8 1.2 3.1 2 1 0 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport His_Phos_1 PF00300.17 EFX01479.1 - 3.5e-11 43.4 0.0 6.9e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.13 EFX01481.1 - 4e-58 196.1 0.0 5.4e-58 195.6 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EFX01481.1 - 3.1e-21 76.1 0.0 4.9e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EFX01481.1 - 0.0027 17.5 0.0 0.0059 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX01481.1 - 0.0036 18.1 0.0 0.01 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNase_H2-Ydr279 PF09468.5 EFX01482.1 - 2.8e-86 289.4 0.0 3.5e-86 289.1 0.0 1.0 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) MFS_1 PF07690.11 EFX01484.1 - 1.3e-29 103.0 31.5 1.9e-29 102.5 21.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4225 PF13988.1 EFX01484.1 - 0.098 12.1 0.4 0.2 11.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) NIF PF03031.13 EFX01485.1 - 3.8e-34 117.6 0.0 5.6e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FAM220 PF15487.1 EFX01486.1 - 2.1 7.6 5.6 3 7.1 3.9 1.2 1 0 0 1 1 1 0 FAM220 family SMC_N PF02463.14 EFX01487.1 - 1.9e-47 161.3 45.4 2.9e-31 108.4 0.5 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AA_kinase PF00696.23 EFX01487.1 - 1.9e-33 116.0 0.1 1.9e-33 116.0 0.1 3.9 4 0 0 4 4 4 1 Amino acid kinase family SMC_hinge PF06470.8 EFX01487.1 - 6.9e-26 90.5 0.0 3e-25 88.5 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain ACT PF01842.20 EFX01487.1 - 4.7e-15 54.7 1.5 1.1e-08 34.4 0.1 3.1 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 EFX01487.1 - 2.2e-12 46.3 4.8 9.1e-09 34.7 0.2 3.1 3 0 0 3 3 3 2 ACT domain AAA_21 PF13304.1 EFX01487.1 - 7e-10 39.3 4.8 0.00027 21.0 0.1 3.2 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EFX01487.1 - 8.8e-10 39.2 18.7 8.8e-10 39.2 13.0 6.5 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.1 EFX01487.1 - 4e-08 32.6 0.0 8.4e-08 31.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain LPP PF04728.8 EFX01487.1 - 8.1e-05 22.3 11.0 0.003 17.3 0.7 4.6 3 0 0 3 3 3 1 Lipoprotein leucine-zipper Reo_sigmaC PF04582.7 EFX01487.1 - 0.0046 16.1 28.3 0.032 13.3 1.6 5.6 6 1 0 6 6 6 2 Reovirus sigma C capsid protein MRP-L20 PF12824.2 EFX01488.1 - 1e-52 178.4 3.3 1.4e-52 177.9 2.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.6 EFX01488.1 - 0.0052 16.6 0.7 0.0066 16.2 0.1 1.5 2 0 0 2 2 2 1 Neugrin ABC_membrane PF00664.18 EFX01489.1 - 3.3e-44 151.3 11.3 4.3e-44 150.9 7.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EFX01489.1 - 2.3e-33 115.3 0.0 3.2e-32 111.6 0.0 2.5 2 0 0 2 2 2 1 ABC transporter CTD_bind PF04818.8 EFX01489.1 - 3.4e-22 78.4 0.1 1.3e-21 76.5 0.1 2.0 2 0 0 2 2 1 1 RNA polymerase II-binding domain. AAA_16 PF13191.1 EFX01489.1 - 2.2e-06 27.7 0.2 1.3e-05 25.3 0.0 2.4 2 0 0 2 2 1 1 AAA ATPase domain SMC_N PF02463.14 EFX01489.1 - 2.4e-05 23.6 0.0 0.00095 18.4 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX01489.1 - 9.2e-05 22.5 0.5 0.53 10.1 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 EFX01489.1 - 0.0014 19.4 0.0 0.0039 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX01489.1 - 0.0037 17.4 0.1 0.035 14.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFX01489.1 - 0.008 15.6 0.1 0.019 14.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.12 EFX01489.1 - 0.0081 15.5 0.2 0.38 10.1 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA PF00004.24 EFX01489.1 - 0.01 16.0 0.0 0.055 13.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFX01489.1 - 0.015 14.6 1.4 0.098 12.0 0.5 2.5 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EFX01489.1 - 0.037 13.7 0.1 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF3277 PF11681.3 EFX01489.1 - 0.061 12.8 0.0 0.19 11.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) SbcCD_C PF13558.1 EFX01489.1 - 0.09 12.7 1.4 0.54 10.2 0.3 2.9 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 EFX01489.1 - 0.092 13.0 0.0 0.28 11.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain HSBP1 PF06825.7 EFX01490.1 - 1.2e-16 60.0 0.6 1.3e-16 59.9 0.4 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 SF-assemblin PF06705.6 EFX01490.1 - 0.0037 16.4 0.2 0.004 16.3 0.1 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin COG2 PF06148.6 EFX01490.1 - 0.018 14.9 0.1 0.02 14.7 0.1 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.7 EFX01490.1 - 0.03 14.1 0.2 0.035 13.9 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 EFX01490.1 - 0.042 13.6 0.2 0.056 13.2 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Matrilin_ccoil PF10393.4 EFX01490.1 - 0.057 12.7 0.3 2.7 7.4 0.0 2.3 1 1 1 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin zf-C2H2_2 PF12756.2 EFX01491.1 - 2.2e-30 104.7 17.8 1.2e-27 95.9 0.1 3.7 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 EFX01491.1 - 1.4e-09 37.8 23.8 7.9e-07 29.0 2.3 4.2 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX01491.1 - 2.8e-07 30.5 9.6 4.6e-07 29.8 1.6 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 EFX01491.1 - 0.0061 16.8 16.7 0.15 12.4 0.3 4.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-DBF PF07535.7 EFX01491.1 - 0.016 14.8 1.8 0.016 14.8 1.3 3.5 3 1 1 4 4 4 0 DBF zinc finger zf-C2H2_4 PF13894.1 EFX01491.1 - 2.7 8.5 13.5 0.7 10.3 0.6 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger Atx10homo_assoc PF09759.4 EFX01492.1 - 1.5e-10 40.6 0.0 4.1e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain RTBV_P12 PF06361.6 EFX01492.1 - 0.43 10.8 2.9 1.1 9.5 1.1 2.3 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein WD40 PF00400.27 EFX01493.1 - 4.5e-58 191.1 22.4 2.5e-09 36.6 0.0 11.9 11 1 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.6 EFX01493.1 - 1.1e-37 128.7 0.0 1.7e-37 128.1 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 EFX01493.1 - 0.0034 15.5 6.5 0.11 10.6 0.0 4.5 5 1 1 6 6 6 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFX01493.1 - 0.037 12.7 0.3 0.73 8.5 0.0 3.1 4 1 0 5 5 5 0 Nup133 N terminal like Abhydrolase_3 PF07859.8 EFX01494.1 - 0.028 13.9 0.0 0.07 12.6 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold YjbR PF04237.8 EFX01495.1 - 0.067 13.5 0.0 0.35 11.2 0.0 2.2 2 0 0 2 2 2 0 YjbR HET PF06985.6 EFX01496.1 - 6.3e-11 42.6 4.6 4.8e-10 39.7 0.3 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) BBE PF08031.7 EFX01497.1 - 0.00015 21.5 0.1 0.00029 20.6 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like Spc97_Spc98 PF04130.8 EFX01498.1 - 6.5e-115 384.4 0.0 1.1e-114 383.7 0.0 1.4 1 0 0 1 1 1 1 Spc97 / Spc98 family Kinesin PF00225.18 EFX01499.1 - 7.1e-110 366.8 0.3 1.6e-109 365.6 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain DUF3694 PF12473.3 EFX01499.1 - 1.7e-15 56.9 0.0 2.4e-14 53.1 0.0 2.6 2 0 0 2 2 2 1 Kinesin protein FHA PF00498.21 EFX01499.1 - 9.5e-06 25.6 0.1 0.00036 20.5 0.0 3.1 3 0 0 3 3 3 1 FHA domain PH PF00169.24 EFX01499.1 - 0.00089 19.4 0.0 0.024 14.8 0.0 2.8 2 1 0 2 2 2 1 PH domain AAA_22 PF13401.1 EFX01499.1 - 0.068 13.3 0.0 0.27 11.3 0.0 2.1 1 0 0 1 1 1 0 AAA domain CASP_C PF08172.7 EFX01500.1 - 1.2e-80 270.0 4.0 4e-80 268.4 0.0 2.5 3 0 0 3 3 3 1 CASP C terminal ADIP PF11559.3 EFX01500.1 - 0.0087 15.9 34.7 0.2 11.5 1.3 5.4 4 2 2 6 6 6 3 Afadin- and alpha -actinin-Binding ATG16 PF08614.6 EFX01500.1 - 0.15 11.8 37.2 1.6 8.5 0.3 5.1 2 1 1 5 5 5 0 Autophagy protein 16 (ATG16) DUF4140 PF13600.1 EFX01500.1 - 0.15 12.4 23.8 4.9 7.6 1.6 5.3 4 2 1 5 5 5 0 N-terminal domain of unknown function (DUF4140) DUF1202 PF06717.6 EFX01500.1 - 0.29 10.3 5.9 5.1 6.2 0.0 3.4 5 0 0 5 5 5 0 Protein of unknown function (DUF1202) Striatin PF08232.7 EFX01500.1 - 1 9.6 23.8 2 8.7 0.0 4.1 3 1 1 4 4 4 0 Striatin family LRS4 PF10422.4 EFX01500.1 - 1.4 8.1 13.3 0.023 14.0 3.5 2.0 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 HALZ PF02183.13 EFX01500.1 - 2.6 7.8 18.9 0.13 12.0 0.5 5.4 5 0 0 5 5 5 0 Homeobox associated leucine zipper XkdW PF09636.5 EFX01500.1 - 3.8 7.4 6.3 1.1 9.1 0.7 2.8 2 0 0 2 2 2 0 XkdW protein CENP-F_leu_zip PF10473.4 EFX01500.1 - 5 6.9 39.9 1.2 8.9 1.0 5.3 3 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.7 EFX01500.1 - 9.8 6.6 18.0 1.6 9.1 0.0 5.1 5 1 0 5 5 4 0 SlyX adh_short PF00106.20 EFX01501.1 - 2.7e-19 69.7 5.1 2.7e-19 69.7 3.6 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFX01501.1 - 2.2e-13 50.2 1.9 2.2e-13 50.2 1.3 1.7 2 0 0 2 2 2 1 KR domain Abhydrolase_2 PF02230.11 EFX01501.1 - 9.4e-08 31.7 0.0 1.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 EFX01501.1 - 1.8e-06 27.7 0.1 4.3e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX01501.1 - 2.8e-05 24.0 7.1 2.8e-05 24.0 4.9 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Epimerase PF01370.16 EFX01501.1 - 0.0012 18.3 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 EFX01501.1 - 0.0026 17.8 0.0 0.0043 17.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 EFX01501.1 - 0.055 13.4 0.9 0.14 12.1 0.6 1.8 1 0 0 1 1 1 0 NADH(P)-binding Hydrolase_4 PF12146.3 EFX01501.1 - 0.098 12.5 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase adh_short_C2 PF13561.1 EFX01502.1 - 1e-28 100.7 0.1 1.2e-28 100.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX01502.1 - 1.3e-28 100.0 1.0 1.6e-28 99.7 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX01502.1 - 3.5e-17 62.6 0.2 4.7e-17 62.2 0.2 1.1 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.21 EFX01502.1 - 0.028 13.9 0.7 0.18 11.3 0.1 2.5 2 1 0 2 2 2 0 Zinc-binding dehydrogenase zf-C2H2 PF00096.21 EFX01503.1 - 4.6e-05 23.5 14.8 0.19 12.1 2.1 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX01503.1 - 0.00032 20.8 15.0 0.66 10.4 2.4 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger adh_short PF00106.20 EFX01504.1 - 1.3e-20 73.9 3.3 1.4e-19 70.6 2.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01504.1 - 3.8e-17 62.8 0.0 1.3e-15 57.7 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01504.1 - 1.2e-08 34.8 1.5 3e-07 30.2 0.1 2.1 2 0 0 2 2 2 2 KR domain DUF572 PF04502.8 EFX01505.1 - 9.9e-68 228.7 8.5 1.2e-67 228.4 5.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) zinc_ribbon_5 PF13719.1 EFX01505.1 - 0.086 12.4 0.3 14 5.3 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EFX01505.1 - 0.099 12.3 0.3 13 5.5 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.1 EFX01505.1 - 0.44 10.8 3.2 4 7.8 0.0 2.8 2 1 1 3 3 3 0 Restriction alleviation protein Lar Bud13 PF09736.4 EFX01505.1 - 5.4 7.2 14.5 1.2 9.4 2.1 2.3 1 1 1 2 2 2 0 Pre-mRNA-splicing factor of RES complex DUF1465 PF07323.7 EFX01506.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) Methyltransf_16 PF10294.4 EFX01506.1 - 0.11 11.8 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative methyltransferase RAMP4 PF06624.7 EFX01507.1 - 1.2e-06 27.9 0.0 1.2e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF1206 PF06724.6 EFX01507.1 - 0.013 15.2 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) EF1G PF00647.14 EFX01508.1 - 2e-41 140.0 0.1 3.7e-41 139.1 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 EFX01508.1 - 7.6e-14 51.4 0.2 7.6e-14 51.4 0.1 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFX01508.1 - 3.3e-12 46.4 0.0 7.3e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFX01508.1 - 4e-12 46.1 0.0 1e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFX01508.1 - 3.3e-09 36.5 1.8 2.1e-08 33.9 0.1 2.7 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFX01508.1 - 1.5e-07 31.2 0.0 3.7e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EFX01508.1 - 2.5e-06 27.8 0.2 1e-05 25.9 0.2 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_60s PF00428.14 EFX01508.1 - 0.75 10.2 14.9 1.7 9.0 10.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein ketoacyl-synt PF00109.21 EFX01509.1 - 2.5e-08 33.7 0.0 4.4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Methyltransf_8 PF05148.10 EFX01510.1 - 1.5e-52 178.4 0.0 3.6e-51 173.9 0.0 2.8 2 1 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 EFX01510.1 - 6.8e-07 29.6 0.0 6.8e-07 29.6 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain TFIIA PF03153.8 EFX01510.1 - 1e-06 28.9 14.6 1.3e-06 28.6 10.1 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Methyltransf_31 PF13847.1 EFX01510.1 - 0.004 16.7 0.0 0.17 11.4 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX01510.1 - 0.0063 16.8 0.1 0.033 14.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EFX01510.1 - 0.047 13.3 0.0 0.047 13.3 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01510.1 - 0.05 13.3 0.0 0.48 10.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 EFX01510.1 - 0.073 12.4 1.6 1.8 7.9 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase small domain PAT1 PF09770.4 EFX01510.1 - 1.9 6.5 41.5 2.5 6.2 28.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Fungal_trans PF04082.13 EFX01511.1 - 9.9e-20 70.4 0.0 2e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01511.1 - 3.4e-11 42.8 8.9 5.8e-11 42.1 6.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dynamin_N PF00350.18 EFX01512.1 - 2.9e-44 150.8 0.0 4.7e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFX01512.1 - 5.3e-10 38.5 0.0 1.9e-08 33.4 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region Miro PF08477.8 EFX01512.1 - 0.0036 17.7 0.0 0.0073 16.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFX01512.1 - 0.0049 16.8 0.0 0.013 15.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.1 EFX01512.1 - 0.19 11.6 0.0 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EFX01512.1 - 0.21 11.5 3.2 0.69 9.8 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain AAA_29 PF13555.1 EFX01512.1 - 1.2 8.7 3.7 1.3 8.5 0.2 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain APH PF01636.18 EFX01513.1 - 0.07 12.8 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Fructosamin_kin PF03881.9 EFX01513.1 - 0.085 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Fructosamine kinase DUF2838 PF10998.3 EFX01514.1 - 4.2e-46 155.4 7.9 4.2e-46 155.4 5.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) DUF3584 PF12128.3 EFX01514.1 - 0.18 9.0 2.6 0.25 8.6 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Cyclin_N PF00134.18 EFX01515.1 - 9.8e-44 147.9 0.0 5.2e-42 142.3 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFX01515.1 - 3.6e-34 117.2 0.1 3.6e-34 117.2 0.1 2.3 2 1 0 2 2 2 1 Cyclin, C-terminal domain Peptidase_S46 PF10459.4 EFX01515.1 - 8.8 4.5 20.7 12 4.1 14.4 1.1 1 0 0 1 1 1 0 Peptidase S46 Peptidase_C12 PF01088.16 EFX01516.1 - 2.3e-62 209.9 0.0 3.2e-62 209.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 adh_short PF00106.20 EFX01517.1 - 6.9e-25 87.8 8.1 9.8e-25 87.3 5.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01517.1 - 2e-20 73.6 0.5 2.3e-20 73.4 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01517.1 - 9e-13 48.2 5.0 1.5e-12 47.5 3.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX01517.1 - 0.0012 18.3 1.2 0.0081 15.6 0.8 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SPOR PF05036.8 EFX01517.1 - 0.058 13.5 0.5 0.38 10.9 0.2 2.4 2 1 1 3 3 3 0 Sporulation related domain DUF1703 PF08011.6 EFX01517.1 - 0.13 11.9 0.0 0.9 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1703) CN_hydrolase PF00795.17 EFX01518.1 - 7e-30 103.7 0.0 9.4e-30 103.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sugar_tr PF00083.19 EFX01519.1 - 3.2e-87 292.9 27.1 3.7e-87 292.7 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX01519.1 - 6.1e-29 100.8 52.2 1.7e-27 96.1 18.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX01519.1 - 2.8e-05 22.5 3.4 2.8e-05 22.5 2.4 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3180 PF11377.3 EFX01519.1 - 2.6 7.8 13.0 0.03 14.1 1.6 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3180) Peptidase_M24 PF00557.19 EFX01520.1 - 1.3e-47 162.0 0.0 1.9e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EFX01520.1 - 1.9e-33 114.6 0.0 4.6e-33 113.4 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain AA_permease PF00324.16 EFX01522.1 - 1.3e-142 475.5 36.2 1.6e-142 475.2 25.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX01522.1 - 6.8e-38 130.3 38.1 9.1e-38 129.8 26.4 1.1 1 0 0 1 1 1 1 Amino acid permease Prefoldin_2 PF01920.15 EFX01523.1 - 9e-20 70.4 2.2 1.1e-19 70.1 1.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit Myb_Cef PF11831.3 EFX01523.1 - 0.01 15.0 0.1 0.011 15.0 0.1 1.2 1 0 0 1 1 1 0 pre-mRNA splicing factor component TMF_TATA_bd PF12325.3 EFX01523.1 - 0.011 15.4 1.8 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4265 PF14085.1 EFX01523.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) Val_tRNA-synt_C PF10458.4 EFX01523.1 - 0.083 12.9 1.5 0.12 12.4 0.1 2.0 2 1 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm FlxA PF14282.1 EFX01523.1 - 0.11 12.4 8.8 2.1 8.3 3.6 2.1 2 0 0 2 2 2 0 FlxA-like protein Striatin PF08232.7 EFX01523.1 - 0.23 11.7 2.5 4.6 7.5 0.1 2.1 2 0 0 2 2 2 0 Striatin family CENP-F_leu_zip PF10473.4 EFX01523.1 - 0.34 10.7 4.4 2.7 7.8 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.15 EFX01523.1 - 0.37 9.8 4.4 0.69 8.9 0.0 2.0 2 0 0 2 2 2 0 Tropomyosin Fib_alpha PF08702.5 EFX01523.1 - 1.3 9.1 4.4 20 5.2 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 EFX01523.1 - 2 8.2 6.0 0.81 9.5 0.1 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding UvdE PF03851.9 EFX01524.1 - 1.9e-100 335.4 0.0 4.7e-100 334.1 0.0 1.6 1 1 0 1 1 1 1 UV-endonuclease UvdE DUF3439 PF11921.3 EFX01524.1 - 0.9 9.2 6.6 1.7 8.3 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FAD_binding_3 PF01494.14 EFX01526.1 - 3.4e-10 39.5 1.0 1e-09 37.9 0.7 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX01526.1 - 2e-07 30.2 4.1 1.3e-05 24.3 1.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX01526.1 - 8.6e-06 25.6 0.4 1.9e-05 24.6 0.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX01526.1 - 7.3e-05 21.7 2.0 0.00014 20.8 1.4 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 EFX01526.1 - 0.00025 21.4 0.2 0.00082 19.7 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX01526.1 - 0.00077 19.5 0.2 0.0025 17.8 0.1 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX01526.1 - 0.0016 18.3 0.5 0.003 17.4 0.3 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX01526.1 - 0.0038 16.3 0.3 0.0072 15.4 0.2 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 EFX01526.1 - 0.014 13.9 1.9 0.032 12.6 0.4 1.9 2 0 0 2 2 2 0 HI0933-like protein ApbA PF02558.11 EFX01526.1 - 0.021 14.2 0.2 0.043 13.2 0.2 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 EFX01526.1 - 0.041 12.7 1.3 0.11 11.3 0.4 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EFX01526.1 - 0.1 11.4 3.4 1.9 7.2 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein UDPG_MGDP_dh_N PF03721.9 EFX01526.1 - 0.11 11.8 0.3 0.22 10.8 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_9 PF13454.1 EFX01526.1 - 0.23 11.1 4.3 7.6 6.2 0.3 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding PI3_PI4_kinase PF00454.22 EFX01527.1 - 1.6e-37 129.2 0.0 3.9e-37 127.9 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase N2227 PF07942.7 EFX01528.1 - 2.3e-92 308.8 0.0 4.3e-91 304.6 0.0 2.0 1 1 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 EFX01528.1 - 1.4e-05 24.8 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX01528.1 - 0.0054 17.1 0.0 0.013 15.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX01528.1 - 0.0063 16.9 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01528.1 - 0.12 12.9 0.0 0.3 11.6 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain HET PF06985.6 EFX01529.1 - 2.2e-20 73.2 0.0 3.9e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SNARE PF05739.14 EFX01530.1 - 3.3e-18 65.1 1.5 3.3e-18 65.1 1.1 3.1 4 0 0 4 4 4 1 SNARE domain Syntaxin PF00804.20 EFX01530.1 - 4.9e-10 39.4 0.1 4.9e-10 39.4 0.1 2.5 2 1 0 2 2 2 1 Syntaxin MCPsignal PF00015.16 EFX01530.1 - 0.1 12.1 9.2 0.57 9.6 1.0 2.9 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Abhydrolase_6 PF12697.2 EFX01531.1 - 3.8e-07 30.2 9.1 6.3e-07 29.4 6.0 1.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX01531.1 - 9.8e-07 28.6 0.2 1.7e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 EFX01531.1 - 0.038 13.2 0.1 5 6.3 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family MFS_1 PF07690.11 EFX01532.1 - 1e-36 126.4 34.8 1e-36 126.4 24.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX01532.1 - 2.2e-06 26.1 1.4 3.8e-06 25.4 0.9 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UCR_14kD PF02271.11 EFX01533.1 - 1.2e-43 147.1 0.3 1.3e-43 146.9 0.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Transketolase_N PF00456.16 EFX01534.1 - 3.9e-154 512.4 0.1 5.2e-154 512.0 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 EFX01534.1 - 1.6e-44 151.5 0.0 2.6e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EFX01534.1 - 1.5e-12 47.4 0.0 5.1e-12 45.8 0.0 1.9 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 EFX01534.1 - 4.9e-06 25.6 0.1 0.0008 18.4 0.0 2.2 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase Nitroreductase PF00881.19 EFX01536.1 - 3.2e-14 53.0 0.0 3.9e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family HNH_2 PF13391.1 EFX01537.1 - 7.4e-05 22.4 0.0 0.00017 21.3 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease DUF4428 PF14471.1 EFX01538.1 - 0.038 13.7 0.0 21 4.9 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) Gly-zipper_OmpA PF13436.1 EFX01538.1 - 0.14 11.8 8.1 0.065 12.8 3.1 2.3 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain DUF218 PF02698.12 EFX01539.1 - 2.8e-06 26.9 0.0 9.6e-06 25.1 0.0 1.8 1 1 0 1 1 1 1 DUF218 domain Trehalose_PPase PF02358.11 EFX01539.1 - 0.037 12.9 0.0 0.07 12.0 0.0 1.5 2 0 0 2 2 2 0 Trehalose-phosphatase A_deaminase PF00962.17 EFX01540.1 - 7.6e-108 360.3 0.1 1e-107 359.9 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase TCTP PF00838.12 EFX01540.1 - 0.056 13.4 0.3 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Translationally controlled tumour protein BAF1_ABF1 PF04684.8 EFX01540.1 - 9 5.0 6.0 0.94 8.2 0.9 1.7 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PQ-loop PF04193.9 EFX01541.1 - 3.9e-31 106.3 7.5 1.3e-15 56.6 0.5 2.5 2 0 0 2 2 2 2 PQ loop repeat Fun_ATP-synt_8 PF05933.8 EFX01541.1 - 0.22 11.5 0.0 0.22 11.5 0.0 2.3 4 0 0 4 4 4 0 Fungal ATP synthase protein 8 (A6L) GTP_EFTU PF00009.22 EFX01542.1 - 2.9e-59 199.6 0.2 3.7e-59 199.3 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFX01542.1 - 2.5e-26 91.7 0.0 1.5e-25 89.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFX01542.1 - 4.3e-16 58.7 2.8 4.3e-16 58.7 1.9 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX01542.1 - 1.3e-05 25.1 0.0 2.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 EFX01542.1 - 0.00038 20.0 0.5 0.0011 18.5 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Miro PF08477.8 EFX01542.1 - 0.0029 18.1 0.0 0.0049 17.3 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 EFX01542.1 - 0.08 12.4 0.3 9.1 5.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Beta_protein PF14350.1 EFX01542.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Beta protein Gtr1_RagA PF04670.7 EFX01542.1 - 0.12 11.5 0.1 0.37 9.9 0.1 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region TPR_11 PF13414.1 EFX01543.1 - 9.3e-11 41.2 0.3 1.5e-05 24.5 0.1 3.8 3 1 0 4 4 4 2 TPR repeat TPR_2 PF07719.12 EFX01543.1 - 1e-10 40.6 0.0 0.00012 21.7 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFX01543.1 - 1.9e-09 37.3 7.8 0.00071 19.9 0.1 4.8 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFX01543.1 - 6.8e-09 35.9 0.8 0.0001 22.5 0.1 4.1 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFX01543.1 - 7.6e-07 28.9 0.0 0.0052 16.7 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFX01543.1 - 8.1e-07 28.3 0.0 0.0049 16.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX01543.1 - 1.6e-06 28.5 9.5 0.00013 22.5 1.0 4.8 3 1 3 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX01543.1 - 1.1e-05 24.7 0.0 0.016 14.8 0.0 3.2 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX01543.1 - 1.6e-05 24.7 0.0 0.026 14.7 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EFX01543.1 - 0.0029 17.4 0.7 1.8 8.4 0.1 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX01543.1 - 0.0055 17.0 3.5 4.9 7.8 0.0 4.1 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_20 PF14561.1 EFX01543.1 - 0.0084 16.1 0.8 0.083 13.0 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFX01543.1 - 0.0086 15.8 0.1 6.5 6.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Alpha_E1_glycop PF01589.11 EFX01543.1 - 0.026 12.8 0.0 0.048 11.9 0.0 1.3 2 0 0 2 2 2 0 Alphavirus E1 glycoprotein PPR_3 PF13812.1 EFX01543.1 - 0.041 14.1 0.1 0.26 11.6 0.0 2.5 2 0 0 2 2 1 0 Pentatricopeptide repeat domain zf-C2H2 PF00096.21 EFX01544.1 - 1.1e-10 41.1 9.4 5.9e-05 23.1 2.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type Fungal_trans PF04082.13 EFX01544.1 - 3.6e-08 32.6 0.1 6.4e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.1 EFX01544.1 - 2.2e-07 30.7 9.1 0.00019 21.5 1.9 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger Zn_clus PF00172.13 EFX01544.1 - 3.7e-06 26.7 8.2 9.3e-06 25.4 5.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.1 EFX01544.1 - 9.2e-05 22.5 1.6 9.2e-05 22.5 1.1 3.9 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2HC_2 PF13913.1 EFX01544.1 - 0.0066 16.0 0.6 0.0066 16.0 0.4 2.7 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-Di19 PF05605.7 EFX01544.1 - 0.013 15.5 7.8 0.072 13.2 2.2 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 EFX01544.1 - 0.019 15.0 4.4 0.58 10.3 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding p450 PF00067.17 EFX01545.1 - 8.7e-41 139.9 0.0 5.6e-40 137.2 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.13 EFX01546.1 - 1.1e-08 34.7 12.5 1.6e-08 34.2 8.6 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.8 EFX01547.1 - 1.1e-37 129.1 5.2 1.9e-37 128.3 0.0 2.8 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF848 PF05852.6 EFX01547.1 - 0.00073 19.4 1.1 0.0011 18.8 0.8 1.2 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) DUF3584 PF12128.3 EFX01547.1 - 0.0019 15.6 7.8 0.0026 15.2 5.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) CR6_interact PF10147.4 EFX01547.1 - 0.0047 16.2 0.1 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Baculo_PEP_C PF04513.7 EFX01547.1 - 0.09 12.5 3.3 2.7 7.8 0.1 2.1 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 EFX01547.1 - 0.1 12.1 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 IncA protein zf-C4H2 PF10146.4 EFX01547.1 - 0.26 11.3 2.7 0.13 12.2 0.1 1.9 2 1 0 2 2 2 0 Zinc finger-containing protein FUSC PF04632.7 EFX01547.1 - 0.31 9.3 3.9 0.43 8.9 2.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4600 PF15372.1 EFX01547.1 - 0.48 10.6 3.4 0.87 9.8 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) RPN7 PF10602.4 EFX01548.1 - 3.6e-52 176.3 0.1 1.2e-51 174.5 0.0 1.9 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 EFX01548.1 - 6.1e-15 55.4 0.0 1.1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 PCI domain Glyco_hydro_2 PF00703.16 EFX01549.1 - 9.1e-09 35.7 0.0 2.4e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.13 EFX01549.1 - 1.2e-05 24.9 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DNA_pol_B_thumb PF14791.1 EFX01550.1 - 4.1e-21 74.4 0.0 7.5e-21 73.5 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 EFX01550.1 - 1.6e-18 65.9 0.1 3.2e-18 65.0 0.1 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.1 EFX01550.1 - 4.4e-15 55.7 0.0 2.9e-14 53.0 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.1 EFX01550.1 - 4.4e-14 52.4 0.0 9.1e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.1 EFX01550.1 - 0.0003 20.8 0.0 0.054 13.6 0.0 2.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain GTP_CH_N PF12471.3 EFX01551.1 - 1.6e-90 301.9 0.0 2.3e-90 301.4 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 EFX01551.1 - 7.5e-14 51.3 0.0 1.9e-13 50.0 0.0 1.6 2 0 0 2 2 2 1 GTP cyclohydrolase II MBOAT PF03062.14 EFX01552.1 - 2.7e-31 108.8 19.2 7.1e-31 107.5 13.3 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MTHFR PF02219.12 EFX01553.1 - 1.4e-97 326.2 0.0 2.1e-97 325.6 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF2414 PF10309.4 EFX01554.1 - 2.6e-17 62.2 0.0 4.4e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2414) Cpn60_TCP1 PF00118.19 EFX01555.1 - 2.8e-146 487.9 0.8 3.2e-146 487.7 0.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.11 EFX01555.1 - 0.16 11.8 1.3 32 4.4 0.0 3.1 3 0 0 3 3 3 0 Enolase, N-terminal domain SelR PF01641.13 EFX01556.1 - 8.6e-43 144.9 0.1 1.1e-42 144.6 0.1 1.2 1 0 0 1 1 1 1 SelR domain DUF2296 PF10058.4 EFX01556.1 - 0.082 12.6 0.1 0.64 9.8 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) DZR PF12773.2 EFX01556.1 - 0.085 12.6 0.8 8.4 6.2 0.1 2.3 2 0 0 2 2 2 0 Double zinc ribbon Trehalase PF01204.13 EFX01557.1 - 3.1e-196 652.9 0.0 3.7e-196 652.7 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 EFX01557.1 - 1e-16 59.8 0.4 1.7e-16 59.1 0.3 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain TPR_11 PF13414.1 EFX01558.1 - 3e-07 29.9 5.8 0.00071 19.1 0.0 4.6 3 1 0 4 4 4 2 TPR repeat TPR_12 PF13424.1 EFX01558.1 - 1e-06 28.5 4.6 8.8e-06 25.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX01558.1 - 1.3e-05 24.7 0.1 0.23 11.4 0.2 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX01558.1 - 1.5e-05 25.4 4.5 0.00075 20.1 0.4 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX01558.1 - 0.0017 17.9 0.0 0.34 10.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX01558.1 - 0.0031 17.8 7.7 0.41 11.0 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFX01558.1 - 0.0086 16.6 7.6 8.8 7.2 0.0 6.3 6 1 1 7 7 7 1 Tetratricopeptide repeat AAA_22 PF13401.1 EFX01558.1 - 0.0095 16.0 0.0 0.09 12.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFX01558.1 - 0.084 12.6 0.0 0.47 10.2 0.0 2.3 1 0 0 1 1 1 0 Part of AAA domain AMP-binding PF00501.23 EFX01559.1 - 9.3e-83 277.9 0.0 1.2e-82 277.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX01559.1 - 5.6e-15 56.0 0.1 2.3e-14 54.0 0.1 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 EFX01559.1 - 0.0018 16.8 0.0 0.011 14.3 0.0 1.9 2 0 0 2 2 2 1 GH3 auxin-responsive promoter Glyco_hydro_12 PF01670.11 EFX01560.1 - 9.9e-34 116.3 0.3 9.9e-34 116.3 0.2 1.8 2 1 0 2 2 2 1 Glycosyl hydrolase family 12 DUF4156 PF13698.1 EFX01560.1 - 0.087 12.7 0.2 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4156) DUF3716 PF12511.3 EFX01561.1 - 5.2e-10 38.7 4.8 9.5e-10 37.9 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Mem_trans PF03547.13 EFX01561.1 - 0.05 11.8 0.6 0.079 11.2 0.4 1.2 1 0 0 1 1 1 0 Membrane transport protein Erp_C PF06780.6 EFX01561.1 - 2 8.2 6.3 0.39 10.5 1.8 1.7 2 0 0 2 2 2 0 Erp protein C-terminus Nbs1_C PF08599.5 EFX01561.1 - 2.3 8.2 5.8 0.82 9.6 0.7 2.7 3 0 0 3 3 3 0 DNA damage repair protein Nbs1 Cullin_binding PF03556.10 EFX01562.1 - 4.2e-27 94.6 2.6 5.4e-27 94.2 1.8 1.1 1 0 0 1 1 1 1 Cullin binding Ribosomal_L18e PF00828.14 EFX01564.1 - 3.2e-17 63.1 0.2 6.2e-17 62.1 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 RRM_1 PF00076.17 EFX01564.1 - 2.5e-08 33.4 0.0 5.5e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01564.1 - 1e-06 28.4 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01564.1 - 0.00015 21.6 0.0 0.0003 20.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFX01564.1 - 0.0003 20.4 0.0 0.00093 18.9 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Indigoidine_A PF04227.7 EFX01566.1 - 2.6e-100 335.4 0.6 4.2e-100 334.7 0.4 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.19 EFX01566.1 - 6.6e-23 81.2 4.5 1.8e-22 79.8 0.8 2.8 2 1 0 2 2 2 1 pfkB family carbohydrate kinase GMC_oxred_N PF00732.14 EFX01567.1 - 2.7e-53 181.0 0.0 3.3e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX01567.1 - 1.3e-33 116.2 0.0 2.2e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 EFX01567.1 - 0.18 10.6 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein UQ_con PF00179.21 EFX01569.1 - 1e-49 167.5 0.0 1.1e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EFX01569.1 - 0.054 13.3 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.1 EFX01569.1 - 0.066 12.9 0.1 0.13 12.0 0.0 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B DAO PF01266.19 EFX01570.1 - 3.1e-45 154.6 0.0 7e-37 127.1 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX01570.1 - 0.00019 21.3 0.1 0.008 16.0 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX01570.1 - 0.0093 15.7 0.2 1.7 8.4 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.17 EFX01570.1 - 0.049 12.4 0.6 0.97 8.2 0.0 2.2 2 1 0 2 2 2 0 Glucose inhibited division protein A 3HCDH_N PF02737.13 EFX01570.1 - 0.075 12.6 0.1 0.16 11.6 0.0 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 EFX01570.1 - 0.087 12.8 0.0 0.83 9.6 0.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2OG-FeII_Oxy PF03171.15 EFX01571.1 - 9.2e-13 48.3 0.0 2.1e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EFX01571.1 - 6.9e-06 26.5 0.0 2e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Mannitol_dh_C PF08125.8 EFX01572.1 - 4.3e-75 252.0 0.0 7.6e-75 251.2 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.18 EFX01572.1 - 1.8e-46 157.8 0.0 2.9e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain UDPGP PF01704.13 EFX01573.1 - 2.2e-185 616.1 0.1 2.6e-185 615.9 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.1 EFX01573.1 - 0.029 12.9 0.3 0.64 8.4 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4301) PilO PF04350.8 EFX01573.1 - 0.08 12.8 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Pilus assembly protein, PilO ABC2_membrane PF01061.19 EFX01574.1 - 2e-86 288.4 50.7 2.2e-44 151.1 15.3 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.22 EFX01574.1 - 3.3e-37 127.8 0.0 2.1e-17 63.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 EFX01574.1 - 1.4e-26 92.1 4.6 1.9e-25 88.5 0.0 2.9 3 0 0 3 3 2 1 CDR ABC transporter ABC2_membrane_3 PF12698.2 EFX01574.1 - 1.7e-10 40.5 41.0 2e-05 23.8 18.4 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_25 PF13481.1 EFX01574.1 - 1.2e-06 28.1 0.5 0.009 15.4 0.0 3.1 2 1 1 3 3 3 2 AAA domain DUF258 PF03193.11 EFX01574.1 - 2.3e-05 23.6 0.0 0.0031 16.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFX01574.1 - 0.00023 21.1 0.4 0.084 12.8 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX01574.1 - 0.00034 20.7 0.1 0.17 12.0 0.1 3.2 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EFX01574.1 - 0.00048 20.1 0.1 0.16 11.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 EFX01574.1 - 0.00067 19.1 0.4 0.23 10.8 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 EFX01574.1 - 0.0015 17.9 0.1 0.08 12.4 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_19 PF13245.1 EFX01574.1 - 0.0019 17.9 0.5 1.3 8.8 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 EFX01574.1 - 0.0056 17.4 0.0 1 10.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.1 EFX01574.1 - 0.0086 16.3 0.1 1.9 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_trans_N PF14510.1 EFX01574.1 - 0.01 15.9 0.0 0.031 14.3 0.0 1.8 1 0 0 1 1 1 0 ABC-transporter extracellular N-terminal AAA_33 PF13671.1 EFX01574.1 - 0.044 13.6 0.1 1.1 9.0 0.0 2.8 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.4 EFX01574.1 - 0.089 12.2 0.3 1.5 8.2 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.18 EFX01574.1 - 0.19 11.6 0.0 26 4.8 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.7 EFX01574.1 - 0.21 11.2 0.7 3.7 7.1 0.2 2.4 2 0 0 2 2 2 0 NACHT domain Miro PF08477.8 EFX01574.1 - 0.28 11.6 0.0 3.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein URO-D PF01208.12 EFX01575.1 - 2e-118 395.2 0.0 2.3e-118 395.0 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) SOR_SNZ PF01680.12 EFX01576.1 - 1.2e-94 315.7 4.8 1.7e-94 315.2 3.3 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 EFX01576.1 - 4.2e-09 35.8 3.1 6e-06 25.5 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG NanE PF04131.9 EFX01576.1 - 0.0014 17.6 0.5 0.047 12.6 0.0 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Dus PF01207.12 EFX01576.1 - 0.0015 17.4 0.7 1 8.1 0.2 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.16 EFX01576.1 - 0.0022 17.3 1.2 0.14 11.4 0.1 3.0 2 1 1 3 3 3 1 Histidine biosynthesis protein IGPS PF00218.16 EFX01576.1 - 0.012 14.7 0.1 0.19 10.7 0.0 2.3 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase NMO PF03060.10 EFX01576.1 - 0.32 10.0 9.0 0.28 10.2 0.3 2.4 2 1 0 2 2 2 0 Nitronate monooxygenase NOB1_Zn_bind PF08772.6 EFX01577.1 - 7.7e-30 102.5 3.2 1.3e-29 101.7 2.2 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like AF1Q PF15017.1 EFX01577.1 - 2.1e-05 24.3 6.8 2.1e-05 24.3 4.7 1.9 2 0 0 2 2 2 1 Drug resistance and apoptosis regulator zf-NADH-PPase PF09297.6 EFX01577.1 - 0.66 9.5 5.2 0.24 10.9 0.7 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain MFS_1 PF07690.11 EFX01578.1 - 5.8e-50 169.9 27.2 9.6e-50 169.2 18.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX01578.1 - 6.7e-13 48.0 10.7 6.7e-13 48.0 7.4 2.9 2 2 0 2 2 2 1 Sugar (and other) transporter RNase_T PF00929.19 EFX01578.1 - 9.5e-12 45.5 0.0 6e-09 36.3 0.0 2.3 2 0 0 2 2 2 2 Exonuclease Fungal_trans PF04082.13 EFX01579.1 - 4.3e-30 104.4 0.0 6.7e-30 103.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mito_carr PF00153.22 EFX01579.1 - 3.7e-26 90.6 0.3 3.3e-12 45.9 0.1 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Fringe PF02434.11 EFX01580.1 - 1.7e-06 27.4 0.1 6.8e-06 25.4 0.1 1.8 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.1 EFX01580.1 - 7.5e-05 22.3 0.5 7.5e-05 22.3 0.4 1.9 2 0 0 2 2 2 1 PAN domain Galactosyl_T PF01762.16 EFX01580.1 - 0.026 14.1 0.0 0.054 13.0 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase PAN_1 PF00024.21 EFX01580.1 - 0.053 13.2 0.0 0.053 13.2 0.0 1.6 2 0 0 2 2 2 0 PAN domain Pyr_redox_3 PF13738.1 EFX01581.1 - 2.5e-23 83.2 0.0 2.6e-22 79.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX01581.1 - 9.9e-09 33.9 2.1 2.3e-08 32.7 0.5 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX01581.1 - 3.3e-08 33.4 0.0 1.2e-07 31.6 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX01581.1 - 4.2e-06 25.9 0.1 4.4e-05 22.5 0.0 2.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFX01581.1 - 4.4e-05 23.4 0.0 0.00013 21.9 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX01581.1 - 0.00061 19.5 0.3 0.019 14.7 0.0 2.8 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 EFX01581.1 - 0.009 14.9 0.0 0.26 10.1 0.0 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase UPF0139 PF03669.8 EFX01582.1 - 0.002 17.5 0.1 0.0027 17.2 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) COOH-NH2_lig PF14395.1 EFX01582.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Phage phiEco32-like COOH.NH2 ligase-type 2 ING PF12998.2 EFX01584.1 - 3.1e-23 82.0 3.2 4.7e-23 81.4 2.3 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 EFX01584.1 - 3e-08 33.2 8.7 5.3e-08 32.4 6.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-RING-like PF08746.6 EFX01584.1 - 0.55 10.2 2.5 1.2 9.2 1.7 1.5 1 0 0 1 1 1 0 RING-like domain Prefoldin PF02996.12 EFX01584.1 - 1.4 8.6 3.7 1.3 8.7 1.1 1.8 2 0 0 2 2 2 0 Prefoldin subunit tRNA_int_endo PF01974.12 EFX01585.1 - 5.6e-20 70.9 0.0 1.2e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Lipase_GDSL_2 PF13472.1 EFX01585.1 - 3.9e-13 49.9 2.5 3.5e-12 46.8 1.2 2.2 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFX01585.1 - 1.7e-08 34.6 0.1 2.9e-08 33.8 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase tRNA_int_endo_N PF02778.9 EFX01585.1 - 1.5e-05 24.4 0.0 0.0003 20.2 0.0 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain DUF1996 PF09362.5 EFX01586.1 - 2.2e-75 253.3 0.1 3.2e-75 252.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Occludin_ELL PF07303.8 EFX01587.1 - 0.22 12.2 5.0 0.88 10.3 3.1 2.3 2 1 0 2 2 2 0 Occludin homology domain Mt_ATP-synt_D PF05873.7 EFX01587.1 - 0.26 10.9 2.5 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DLD PF14878.1 EFX01587.1 - 0.42 10.7 2.7 2.6 8.1 0.1 2.4 1 1 1 2 2 2 0 Death-like domain of SPT6 CENP-H PF05837.7 EFX01587.1 - 1.4 9.1 5.5 0.69 10.1 1.7 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Ferritin_2 PF13668.1 EFX01588.1 - 2.8e-15 56.4 0.0 4.9e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Ferritin-like domain Ferritin-like PF12902.2 EFX01588.1 - 0.045 13.3 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 Ferritin-like CRC_subunit PF08624.5 EFX01590.1 - 2.5e-56 189.4 0.0 4e-56 188.7 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Glyco_hydro_63 PF03200.11 EFX01591.1 - 1.2e-238 794.0 0.0 1e-237 790.9 0.0 1.9 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Trehalase PF01204.13 EFX01591.1 - 2.7e-06 26.3 0.0 5e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.9 EFX01591.1 - 0.058 12.1 0.0 0.11 11.1 0.0 1.4 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase IATP PF04568.7 EFX01592.1 - 3.8 7.6 5.5 0.58 10.2 0.9 1.8 1 1 1 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Homeobox PF00046.24 EFX01593.1 - 1.3e-14 53.5 1.6 3.1e-14 52.3 1.1 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EFX01593.1 - 0.0026 17.3 1.8 0.0073 15.9 0.8 2.0 2 0 0 2 2 2 1 Homeobox KN domain ADK PF00406.17 EFX01594.1 - 5.1e-22 78.3 0.0 6e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 EFX01594.1 - 1e-11 45.7 0.0 1.2e-11 45.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX01594.1 - 2.9e-08 34.0 0.0 3.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFX01594.1 - 3.6e-05 23.6 0.0 3.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EFX01594.1 - 0.0006 19.8 0.0 0.00082 19.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX01594.1 - 0.002 18.2 0.1 0.0045 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EFX01594.1 - 0.0025 18.0 0.0 0.0038 17.4 0.0 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EFX01594.1 - 0.0059 15.7 0.0 0.0088 15.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Viral_helicase1 PF01443.13 EFX01594.1 - 0.0065 16.0 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 EFX01594.1 - 0.0085 16.4 0.0 0.0094 16.2 0.0 1.3 1 1 0 1 1 1 1 ABC transporter Cytidylate_kin2 PF13189.1 EFX01594.1 - 0.012 15.4 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase-like family UPF0079 PF02367.12 EFX01594.1 - 0.02 14.4 0.1 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_16 PF13191.1 EFX01594.1 - 0.028 14.4 0.2 0.077 12.9 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 EFX01594.1 - 0.029 14.5 0.0 0.055 13.6 0.0 1.5 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.1 EFX01594.1 - 0.043 13.7 0.0 0.055 13.3 0.0 1.3 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 EFX01594.1 - 0.056 13.1 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.17 EFX01594.1 - 0.078 11.8 0.1 0.15 10.8 0.0 1.5 1 1 0 1 1 1 0 NB-ARC domain cobW PF02492.14 EFX01594.1 - 0.08 12.3 0.0 0.18 11.2 0.0 1.5 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.17 EFX01594.1 - 0.083 12.3 0.0 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.1 EFX01594.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFX01594.1 - 0.091 12.4 0.7 0.23 11.0 0.5 1.9 1 1 0 1 1 1 0 NACHT domain MobB PF03205.9 EFX01594.1 - 0.097 12.3 0.1 0.24 11.0 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RuvB_N PF05496.7 EFX01594.1 - 0.12 11.4 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus MMR_HSR1 PF01926.18 EFX01594.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.4 EFX01594.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 EFX01594.1 - 0.16 10.6 0.1 0.32 9.7 0.0 1.4 1 0 0 1 1 1 0 ArgK protein 14-3-3 PF00244.15 EFX01595.1 - 1e-115 384.8 5.9 1.2e-115 384.5 4.1 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF837 PF05769.6 EFX01595.1 - 0.037 13.5 2.6 2.5 7.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF837) RPAP2_Rtr1 PF04181.8 EFX01596.1 - 0.047 13.7 0.2 0.053 13.6 0.1 1.2 1 0 0 1 1 1 0 Rtr1/RPAP2 family Peptidase_C14 PF00656.17 EFX01597.1 - 0.013 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Caspase domain MFS_1 PF07690.11 EFX01598.1 - 9.4e-27 93.6 30.8 1.2e-26 93.3 21.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily GlpM PF06942.7 EFX01598.1 - 0.0083 16.3 2.2 0.027 14.6 1.5 1.8 1 0 0 1 1 1 1 GlpM protein HET PF06985.6 EFX01599.1 - 1.3e-22 80.4 4.0 1.7e-22 80.0 1.5 2.1 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.20 EFX01599.1 - 7.9e-19 67.8 0.0 1.4e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01599.1 - 8.6e-12 44.6 0.0 1.6e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pollen_Ole_e_I PF01190.12 EFX01599.1 - 0.028 14.2 0.3 0.071 12.9 0.1 1.7 2 0 0 2 2 2 0 Pollen proteins Ole e I like Glyco_hydro_28 PF00295.12 EFX01600.1 - 3.3e-22 78.8 0.3 5.4e-22 78.1 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.2 EFX01600.1 - 3.6e-08 33.7 6.9 2.1e-06 28.0 4.8 3.0 1 1 0 1 1 1 1 Pectate lyase superfamily protein SGS PF05002.10 EFX01601.1 - 8.3e-25 86.3 0.4 2.3e-24 84.9 0.3 1.8 1 0 0 1 1 1 1 SGS domain CS PF04969.11 EFX01601.1 - 1.7e-08 34.9 0.0 3.1e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.1 EFX01601.1 - 0.00049 19.6 4.3 0.00094 18.7 0.6 2.3 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 EFX01601.1 - 0.05 13.2 3.8 0.57 9.8 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFX01601.1 - 0.2 11.6 7.7 4.4 7.4 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat Ank_2 PF12796.2 EFX01602.1 - 1.1e-30 105.7 0.2 1.1e-18 67.3 0.0 4.4 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX01602.1 - 7.7e-23 80.4 7.6 7.8e-09 35.8 0.0 5.2 3 1 2 5 5 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX01602.1 - 1.6e-20 72.6 12.4 6.3e-10 38.9 0.2 7.1 4 1 3 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.25 EFX01602.1 - 9.5e-20 69.3 9.6 8e-06 25.4 0.1 8.0 7 2 0 7 7 7 3 Ankyrin repeat Ank_3 PF13606.1 EFX01602.1 - 1.7e-15 55.5 0.5 0.0014 18.6 0.0 6.5 6 0 0 6 6 5 3 Ankyrin repeat AAA_16 PF13191.1 EFX01602.1 - 6.9e-08 32.6 0.2 3.2e-07 30.5 0.2 2.2 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 EFX01602.1 - 1.2e-07 31.4 0.0 3.9e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EFX01602.1 - 1.7e-05 24.9 0.1 9.6e-05 22.5 0.0 2.4 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 EFX01602.1 - 0.00019 20.6 0.0 0.0028 16.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 EFX01602.1 - 0.0067 15.8 0.0 0.017 14.5 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA PF00004.24 EFX01602.1 - 0.014 15.6 0.0 0.08 13.1 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.9 EFX01602.1 - 0.022 13.7 0.0 0.71 8.7 0.0 2.4 1 1 0 1 1 1 0 KAP family P-loop domain RNA_helicase PF00910.17 EFX01602.1 - 0.039 14.1 0.0 0.28 11.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.1 EFX01602.1 - 0.05 14.4 0.0 0.17 12.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EFX01602.1 - 0.068 12.3 0.0 0.76 8.9 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein MobB PF03205.9 EFX01602.1 - 0.081 12.6 0.0 13 5.5 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activat PF00158.21 EFX01602.1 - 0.089 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Spo0A_C PF08769.6 EFX01602.1 - 0.11 12.3 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal Abhydrolase_3 PF07859.8 EFX01603.1 - 7.8e-40 136.7 1.4 1.9e-38 132.1 1.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX01603.1 - 2.6e-06 27.2 0.2 3.2e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX01603.1 - 0.00048 19.3 0.1 0.0031 16.7 0.1 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family COesterase PF00135.23 EFX01603.1 - 0.0063 15.2 0.3 0.06 12.0 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.4 EFX01603.1 - 0.0076 15.5 0.3 0.014 14.6 0.2 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase DUF2424 PF10340.4 EFX01603.1 - 0.047 12.3 0.0 0.079 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) AXE1 PF05448.7 EFX01603.1 - 0.071 11.5 0.3 0.13 10.7 0.2 1.4 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) PALP PF00291.20 EFX01604.1 - 3.7e-27 95.3 0.2 5.5e-27 94.7 0.2 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Fungal_trans PF04082.13 EFX01604.1 - 7.8e-26 90.4 0.1 1.3e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01604.1 - 1.1e-05 25.2 11.1 2.3e-05 24.2 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NUT_C PF12882.2 EFX01604.1 - 0.1 12.2 0.3 0.19 11.3 0.2 1.3 1 0 0 1 1 1 0 NUT protein C terminal HET PF06985.6 EFX01605.1 - 2.4e-15 56.9 0.3 3.9e-15 56.2 0.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NACHT PF05729.7 EFX01606.1 - 1.6e-07 31.1 0.0 0.0035 17.0 0.0 2.9 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.1 EFX01606.1 - 0.0002 21.5 0.8 0.0048 17.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 EFX01606.1 - 0.0017 18.3 0.0 0.0087 16.0 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_10 PF12846.2 EFX01606.1 - 0.0035 16.8 0.2 0.026 13.9 0.1 2.3 2 0 0 2 2 2 1 AAA-like domain AAA_17 PF13207.1 EFX01606.1 - 0.029 15.1 0.0 0.16 12.7 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EFX01606.1 - 0.034 13.6 0.5 0.27 10.8 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ank PF00023.25 EFX01606.1 - 0.056 13.2 0.0 20 5.1 0.0 4.0 4 0 0 4 4 4 0 Ankyrin repeat Ribul_P_3_epim PF00834.14 EFX01606.1 - 0.092 11.8 0.1 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family ABC_tran PF00005.22 EFX01606.1 - 0.096 12.9 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.17 EFX01606.1 - 0.14 12.2 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Sugar_tr PF00083.19 EFX01607.1 - 1.4e-73 248.0 21.1 1.6e-73 247.8 14.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX01607.1 - 4e-14 52.0 20.1 4e-14 52.0 13.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF791 PF05631.9 EFX01607.1 - 0.00044 19.0 4.9 0.0022 16.7 0.6 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF791) OEP PF02321.13 EFX01607.1 - 0.033 13.7 2.4 0.078 12.5 0.2 2.2 2 0 0 2 2 2 0 Outer membrane efflux protein HMG_box PF00505.14 EFX01608.1 - 2.2e-17 63.0 0.5 2.2e-17 63.0 0.4 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFX01608.1 - 3.5e-15 56.1 1.9 1.3e-13 51.0 0.2 2.5 2 0 0 2 2 2 1 HMG-box domain SAM_1 PF00536.25 EFX01608.1 - 7.3e-12 45.2 0.1 1.3e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 EFX01608.1 - 2.9e-11 43.0 0.1 4.9e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3808 PF10300.4 EFX01609.1 - 3.3e-121 405.1 0.0 3.9e-121 404.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_19 PF14559.1 EFX01609.1 - 0.16 12.3 7.2 17 5.8 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Ank_2 PF12796.2 EFX01610.1 - 1.1e-68 227.5 18.6 5.7e-19 68.2 0.1 5.8 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01610.1 - 3e-47 156.1 12.9 2.3e-07 30.2 0.0 10.0 10 1 0 10 10 10 8 Ankyrin repeat Ank_4 PF13637.1 EFX01610.1 - 2e-46 155.5 7.8 2.2e-14 53.5 0.0 8.7 3 3 5 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX01610.1 - 2.1e-38 129.4 18.3 7.3e-10 38.7 0.0 7.7 3 3 5 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX01610.1 - 4.2e-30 100.8 6.6 0.00037 20.4 0.0 9.7 9 0 0 9 9 9 7 Ankyrin repeat DUF4396 PF14342.1 EFX01612.1 - 1.5e-28 99.6 0.7 2.5e-28 98.9 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) HLH PF00010.21 EFX01613.1 - 1.1e-12 47.3 0.6 2.1e-12 46.5 0.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ADK PF00406.17 EFX01614.1 - 6.9e-43 146.1 0.0 1e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 EFX01614.1 - 4.4e-07 30.2 0.0 6.6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX01614.1 - 7.8e-07 29.9 0.0 1.4e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFX01614.1 - 2.4e-06 27.4 0.1 2.2e-05 24.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.12 EFX01614.1 - 0.00098 18.5 0.0 0.83 8.9 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase Mito_fiss_reg PF05308.6 EFX01614.1 - 0.0063 15.9 1.5 0.0098 15.2 1.1 1.3 1 0 0 1 1 1 1 Mitochondrial fission regulator AAA_19 PF13245.1 EFX01614.1 - 0.059 13.1 1.6 0.31 10.8 0.0 2.5 3 0 0 3 3 3 0 Part of AAA domain Pex14_N PF04695.8 EFX01614.1 - 0.099 12.6 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CAP_N PF01213.14 EFX01614.1 - 0.27 10.5 7.5 0.48 9.6 5.2 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HSP70 PF00012.15 EFX01615.1 - 1.7e-70 237.6 2.0 3e-70 236.8 1.4 1.4 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFX01615.1 - 2.6e-08 32.8 5.0 9.2e-08 31.0 3.5 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Nucleoplasmin PF03066.10 EFX01615.1 - 4.7e-05 22.9 4.0 9.6e-05 21.9 2.8 1.5 1 0 0 1 1 1 1 Nucleoplasmin Hydantoinase_A PF01968.13 EFX01615.1 - 0.009 15.1 6.0 0.048 12.7 3.5 2.5 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase BRAP2 PF07576.7 EFX01615.1 - 0.017 14.6 0.1 0.043 13.3 0.0 1.6 1 0 0 1 1 1 0 BRCA1-associated protein 2 FAM176 PF14851.1 EFX01615.1 - 0.061 13.0 4.8 3.9 7.1 3.1 2.5 2 0 0 2 2 2 0 FAM176 family YL1 PF05764.8 EFX01615.1 - 0.26 10.8 6.5 0.44 10.1 4.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein PBP1_TM PF14812.1 EFX01615.1 - 0.42 10.9 13.7 0.8 10.0 9.5 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.7 EFX01615.1 - 0.52 8.1 8.1 0.79 7.5 5.6 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 EFX01615.1 - 0.72 8.5 17.0 1.3 7.7 11.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.6 EFX01615.1 - 0.93 9.2 6.2 1.7 8.4 4.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal CDC45 PF02724.9 EFX01615.1 - 1.5 6.7 8.1 2.2 6.1 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 EFX01615.1 - 2.3 6.6 10.3 3.4 6.0 7.1 1.2 1 0 0 1 1 1 0 Daxx Family Sigma70_ner PF04546.8 EFX01615.1 - 3.7 7.1 13.3 0.98 8.9 6.9 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region Tom22 PF04281.8 EFX01615.1 - 5.1 6.6 9.5 14 5.1 6.6 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Cwf_Cwc_15 PF04889.7 EFX01615.1 - 6.5 6.3 13.0 11 5.6 9.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Bac_rhodopsin PF01036.13 EFX01616.1 - 3.4e-28 98.4 30.8 4.5e-28 98.0 21.4 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein HET PF06985.6 EFX01617.1 - 3.5e-16 59.6 0.2 1.8e-15 57.2 0.0 2.3 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.18 EFX01618.1 - 2.6e-05 23.1 0.0 3.5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain IATP PF04568.7 EFX01620.1 - 2.1e-17 62.9 0.1 2.3e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF1003 PF06210.6 EFX01620.1 - 0.046 13.6 0.8 0.058 13.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) AAA PF00004.24 EFX01622.1 - 3e-07 30.6 0.0 5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zot PF05707.7 EFX01622.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) FAD_binding_3 PF01494.14 EFX01624.1 - 5.5e-74 249.3 0.0 7.2e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 EFX01624.1 - 3.7e-34 117.7 0.0 6.2e-34 117.0 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.9 EFX01624.1 - 3.7e-06 26.9 0.0 6.9e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX01624.1 - 9.8e-06 25.5 0.0 2.2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFX01624.1 - 9.9e-06 24.2 0.2 1.6e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EFX01624.1 - 1.5e-05 25.2 0.0 0.0016 18.7 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX01624.1 - 9.9e-05 21.1 0.0 0.00018 20.2 0.0 1.4 1 0 0 1 1 1 1 Tryptophan halogenase DAO PF01266.19 EFX01624.1 - 0.00023 20.1 0.0 0.0022 16.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX01624.1 - 0.00031 20.8 0.4 0.00075 19.6 0.3 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX01624.1 - 0.00039 19.5 0.0 0.00076 18.6 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 EFX01624.1 - 0.0021 17.0 0.1 0.0032 16.4 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 EFX01624.1 - 0.0029 16.5 0.0 0.0046 15.8 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX01624.1 - 0.0078 15.3 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX01624.1 - 0.02 13.7 0.1 0.033 13.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain XdhC_C PF13478.1 EFX01624.1 - 0.034 14.4 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.14 EFX01624.1 - 0.035 13.2 0.0 0.17 11.0 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.1 EFX01624.1 - 0.036 13.8 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding ThiF PF00899.16 EFX01624.1 - 0.038 13.8 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 ThiF family 3HCDH_N PF02737.13 EFX01624.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 EFX01624.1 - 0.078 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Septin PF00735.13 EFX01625.1 - 1.1e-29 103.3 0.0 9e-12 44.5 0.0 3.2 3 0 0 3 3 3 3 Septin Dynamin_N PF00350.18 EFX01625.1 - 0.01 15.6 0.3 0.052 13.3 0.0 2.2 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.13 EFX01625.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family G-alpha PF00503.15 EFX01625.1 - 0.1 11.2 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit Miro PF08477.8 EFX01625.1 - 0.16 12.4 0.0 0.46 10.9 0.0 1.8 1 1 0 1 1 1 0 Miro-like protein ADH_N PF08240.7 EFX01626.1 - 2.4e-07 30.4 0.0 4.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF4514 PF14986.1 EFX01626.1 - 0.017 14.9 0.2 0.035 13.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) SLD3 PF08639.5 EFX01627.1 - 9.6e-110 367.5 0.0 9.9e-109 364.2 0.0 2.3 1 1 0 1 1 1 1 DNA replication regulator SLD3 HMGL-like PF00682.14 EFX01628.1 - 2e-45 155.3 0.0 2.9e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 HMGL-like ECH PF00378.15 EFX01628.1 - 2.1e-39 135.1 0.0 3.2e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Pkinase PF00069.20 EFX01629.1 - 6.5e-76 254.9 0.0 9.2e-76 254.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01629.1 - 1.5e-37 129.1 0.0 2e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 EFX01629.1 - 2.5e-15 56.3 0.0 4.7e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.1 EFX01629.1 - 1e-11 44.3 0.0 5.6e-08 32.0 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 EFX01629.1 - 0.0022 17.0 0.1 0.0045 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 EFX01629.1 - 0.019 13.7 0.0 0.03 13.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.18 EFX01629.1 - 0.047 13.4 0.3 0.23 11.1 0.2 2.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EFX01629.1 - 0.1 11.9 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Telomerase_RBD PF12009.3 EFX01630.1 - 4.6e-43 146.3 0.3 1.2e-42 145.1 0.1 1.8 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 EFX01630.1 - 8.5e-13 48.1 0.0 5.4e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NST1 PF13945.1 EFX01631.1 - 2.3e-48 164.7 19.4 2.3e-48 164.7 13.5 4.7 2 2 3 5 5 5 1 Salt tolerance down-regulator WD40 PF00400.27 EFX01631.1 - 0.1 12.5 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat zf-C2H2 PF00096.21 EFX01632.1 - 1.4e-07 31.4 19.9 0.016 15.4 0.9 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX01632.1 - 7.5e-07 29.0 14.9 0.026 14.8 0.3 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX01632.1 - 0.34 11.2 24.6 1.4 9.3 2.7 4.2 4 0 0 4 4 4 0 Zinc-finger double domain DBD_Tnp_Mut PF03108.10 EFX01633.1 - 0.04 13.4 0.1 0.097 12.2 0.1 1.6 1 0 0 1 1 1 0 MuDR family transposase DUF244 PF03112.9 EFX01633.1 - 0.049 13.1 0.0 0.083 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF TGT_C1 PF14809.1 EFX01633.1 - 0.15 11.9 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 C1 domain of tRNA-guanine transglycosylase dimerisation Trs65 PF12735.2 EFX01634.1 - 1.5e-46 159.1 0.0 3.4e-45 154.6 0.0 2.3 1 1 0 1 1 1 1 TRAPP trafficking subunit Trs65 Pkinase PF00069.20 EFX01635.1 - 7.2e-56 189.2 0.1 7.1e-40 136.7 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01635.1 - 1.3e-26 93.2 0.3 7.8e-21 74.3 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFX01635.1 - 0.00011 21.3 0.0 0.00024 20.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX01635.1 - 0.00064 18.8 0.0 0.0013 17.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX01635.1 - 0.00076 19.2 2.4 0.018 14.7 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_C PF00433.19 EFX01635.1 - 0.033 14.7 0.4 0.092 13.2 0.3 1.8 1 0 0 1 1 1 0 Protein kinase C terminal domain Pox_ser-thr_kin PF05445.6 EFX01635.1 - 0.042 12.6 0.1 0.067 11.9 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 EFX01635.1 - 0.072 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WaaY PF06176.6 EFX01635.1 - 0.085 12.0 0.6 0.13 11.4 0.4 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 EFX01635.1 - 0.43 9.9 3.1 0.33 10.2 0.0 2.0 2 0 0 2 2 2 0 RIO1 family DUF605 PF04652.11 EFX01636.1 - 1.7 7.9 12.2 2.3 7.5 8.5 1.3 1 0 0 1 1 1 0 Vta1 like Glyco_hydro_12 PF01670.11 EFX01637.1 - 9.3e-16 57.9 1.1 1.8e-15 57.0 0.8 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 HET PF06985.6 EFX01638.1 - 9.8e-21 74.3 0.0 1.7e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.2 EFX01639.1 - 3.4e-13 49.7 0.2 2.5e-08 34.1 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01639.1 - 4.2e-12 45.2 12.8 6e-07 28.9 0.2 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.1 EFX01639.1 - 5.8e-07 29.1 4.1 0.00023 21.0 0.1 4.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.1 EFX01639.1 - 3.8e-05 23.8 6.0 0.00068 19.7 0.1 4.4 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX01639.1 - 6.7e-05 23.2 0.7 0.0079 16.6 0.0 4.0 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Spherulin4 PF12138.3 EFX01640.1 - 7.5e-35 120.5 0.3 1.7e-34 119.3 0.2 1.6 1 1 0 1 1 1 1 Spherulation-specific family 4 CAP59_mtransfer PF11735.3 EFX01642.1 - 7.4e-85 284.0 0.0 1.4e-84 283.1 0.0 1.4 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 RabGAP-TBC PF00566.13 EFX01643.1 - 5.8e-38 130.5 2.2 1.3e-37 129.3 1.5 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.3 EFX01643.1 - 1.2e-10 41.0 0.0 0.00059 19.1 0.0 4.2 5 0 0 5 5 5 3 Domain of unknown function (DUF3548) LSM PF01423.17 EFX01645.1 - 3.2e-15 55.4 0.3 4.5e-15 54.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain HMG_CoA_synt_C PF08540.5 EFX01646.1 - 1.1e-100 336.7 0.2 1.4e-100 336.4 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 EFX01646.1 - 5e-90 299.6 0.2 9.5e-90 298.7 0.1 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal TPR_11 PF13414.1 EFX01647.1 - 4e-20 71.2 12.1 1.4e-15 56.6 3.1 3.2 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 EFX01647.1 - 2.7e-17 61.2 7.1 2.6e-05 23.7 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX01647.1 - 2.7e-16 58.3 11.7 8.1e-06 25.2 0.2 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX01647.1 - 1.6e-08 34.4 4.1 0.016 15.8 0.7 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFX01647.1 - 2.7e-08 34.2 8.2 5.2e-07 30.1 2.8 2.6 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX01647.1 - 1e-07 31.5 7.9 0.0046 17.0 0.4 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFX01647.1 - 2.9e-07 30.3 6.2 0.00025 20.9 1.4 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX01647.1 - 3.4e-06 27.3 5.9 0.00038 20.7 2.0 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFX01647.1 - 1.5e-05 24.3 11.5 0.016 14.9 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFX01647.1 - 5.1e-05 22.7 0.5 0.71 9.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.12 EFX01647.1 - 0.00022 21.5 0.3 0.094 13.0 0.1 2.3 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_6 PF13174.1 EFX01647.1 - 0.0071 16.7 7.4 2.4 8.8 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFX01647.1 - 0.037 13.8 0.2 0.14 12.0 0.1 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat XPC-binding PF09280.6 EFX01647.1 - 0.044 13.2 3.5 0.046 13.1 1.3 1.8 2 0 0 2 2 2 0 XPC-binding domain TPR_10 PF13374.1 EFX01647.1 - 0.23 11.4 1.5 4.7 7.2 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 EFX01647.1 - 1.9 8.4 14.7 0.61 10.0 2.0 3.6 2 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Actino_peptide PF14408.1 EFX01648.1 - 0.26 11.2 4.6 2.4 8.1 1.0 2.4 2 0 0 2 2 2 0 Ribosomally synthesized peptide in actinomycetes Malate_DH PF12434.3 EFX01648.1 - 7 6.4 6.7 38 4.0 0.1 2.4 2 0 0 2 2 2 0 Malate dehydrogenase enzyme Rhomboid PF01694.17 EFX01649.1 - 1.5e-17 63.9 18.1 1.3e-16 60.9 9.0 2.2 1 1 1 2 2 2 2 Rhomboid family TPR_12 PF13424.1 EFX01649.1 - 1.4e-06 28.1 2.3 0.00024 20.9 0.2 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat PPR_3 PF13812.1 EFX01649.1 - 0.0056 16.8 0.1 0.33 11.3 0.0 2.9 2 0 0 2 2 2 1 Pentatricopeptide repeat domain HrpJ PF07201.6 EFX01649.1 - 0.037 14.0 6.3 0.11 12.5 4.4 1.8 1 0 0 1 1 1 0 HrpJ-like domain WW PF00397.21 EFX01651.1 - 5.3e-09 35.7 0.2 1.5e-08 34.3 0.1 1.9 1 0 0 1 1 1 1 WW domain Med15 PF09606.5 EFX01651.1 - 6.6e-05 21.3 71.5 0.00014 20.2 49.6 1.6 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal SAPS PF04499.10 EFX01651.1 - 3 6.3 5.9 4.4 5.8 4.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pkinase PF00069.20 EFX01653.1 - 4e-21 75.3 0.0 6.1e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01653.1 - 1e-15 57.4 0.0 1.8e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase VPS9 PF02204.13 EFX01654.1 - 1.4e-31 108.6 0.2 2.4e-31 107.8 0.2 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 EFX01654.1 - 5e-08 32.2 0.1 6e-07 28.8 0.0 2.3 2 0 0 2 2 2 1 CUE domain MFS_1 PF07690.11 EFX01657.1 - 0.0012 17.6 2.2 0.0012 17.6 1.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DEAD PF00270.24 EFX01659.1 - 1.9e-43 147.8 0.0 4.8e-42 143.3 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX01659.1 - 7.4e-26 89.8 0.3 1.9e-25 88.5 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3334 PF11813.3 EFX01659.1 - 0.042 13.3 0.0 0.19 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3334) V-SNARE PF05008.10 EFX01660.1 - 0.0048 17.0 2.1 0.0048 17.0 1.5 1.9 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus IncA PF04156.9 EFX01660.1 - 0.0068 16.0 0.8 0.011 15.3 0.6 1.2 1 0 0 1 1 1 1 IncA protein Myosin_tail_1 PF01576.14 EFX01660.1 - 0.018 12.7 1.7 0.021 12.5 1.2 1.1 1 0 0 1 1 1 0 Myosin tail DivIVA PF05103.8 EFX01660.1 - 0.053 13.5 1.0 0.12 12.4 0.7 1.5 1 0 0 1 1 1 0 DivIVA protein CorA PF01544.13 EFX01660.1 - 0.063 12.3 0.2 0.082 11.9 0.2 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ERM PF00769.14 EFX01660.1 - 0.086 12.3 2.3 0.15 11.5 1.6 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family TRAM1 PF08390.6 EFX01660.1 - 0.11 12.0 0.0 8.1 6.0 0.0 2.4 2 0 0 2 2 2 0 TRAM1-like protein Aminotran_5 PF00266.14 EFX01661.1 - 8.1e-29 100.4 0.0 4.9e-18 65.0 0.0 2.2 1 1 1 2 2 2 2 Aminotransferase class-V DJ-1_PfpI PF01965.19 EFX01661.1 - 0.07 12.5 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family Arrestin_N PF00339.24 EFX01662.1 - 3.8e-13 49.5 8.1 6.3e-13 48.8 0.0 3.3 4 1 0 4 4 1 1 Arrestin (or S-antigen), N-terminal domain SAGA-Tad1 PF12767.2 EFX01662.1 - 7e-05 22.6 6.1 7e-05 22.6 4.2 2.6 4 0 0 4 4 2 1 Transcriptional regulator of RNA polII, SAGA, subunit FLO_LFY PF01698.11 EFX01662.1 - 0.003 16.4 13.8 0.0047 15.8 9.6 1.2 1 0 0 1 1 1 1 Floricaula / Leafy protein CDC45 PF02724.9 EFX01662.1 - 0.004 15.2 18.7 0.0058 14.7 12.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Ycf1 PF05758.7 EFX01662.1 - 0.0052 14.5 12.4 0.0072 14.1 8.6 1.1 1 0 0 1 1 1 1 Ycf1 SAPS PF04499.10 EFX01662.1 - 0.039 12.5 9.4 0.058 12.0 6.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LMBR1 PF04791.11 EFX01662.1 - 0.049 12.2 0.7 0.071 11.6 0.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Spore_coat_CotO PF14153.1 EFX01662.1 - 0.06 12.7 21.7 0.11 11.8 15.1 1.4 1 0 0 1 1 1 0 Spore coat protein CotO eIF-3_zeta PF05091.7 EFX01662.1 - 0.061 11.9 16.3 0.091 11.3 11.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Mem_trans PF03547.13 EFX01662.1 - 0.15 10.3 0.3 0.22 9.7 0.2 1.2 1 0 0 1 1 1 0 Membrane transport protein Borrelia_P83 PF05262.6 EFX01662.1 - 0.15 10.2 16.9 0.22 9.7 11.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Nop53 PF07767.6 EFX01662.1 - 0.2 10.5 30.7 0.33 9.8 21.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2201_N PF13203.1 EFX01662.1 - 0.28 10.3 22.5 0.61 9.1 15.6 1.5 1 0 0 1 1 1 0 Putative metallopeptidase domain GAGA_bind PF06217.7 EFX01662.1 - 0.29 11.0 18.5 0.53 10.1 12.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.7 EFX01662.1 - 0.41 10.4 19.5 0.82 9.5 13.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.1 EFX01662.1 - 0.5 10.0 12.9 1.5 8.4 9.0 1.8 1 0 0 1 1 1 0 Protein Family FAM60A eIF3_subunit PF08597.5 EFX01662.1 - 0.58 9.6 26.5 1 8.8 18.4 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Band_3_cyto PF07565.8 EFX01662.1 - 0.77 9.2 11.0 1.3 8.4 7.6 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CRT10 PF08728.5 EFX01662.1 - 1.6 6.6 5.9 2.1 6.2 4.1 1.1 1 0 0 1 1 1 0 CRT10 DDHD PF02862.12 EFX01662.1 - 1.6 8.4 16.9 4.7 6.9 11.7 1.8 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.2 EFX01662.1 - 1.6 6.2 17.2 1.3 6.5 11.0 1.4 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Presenilin PF01080.12 EFX01662.1 - 2.3 6.9 14.5 5.2 5.7 10.1 1.5 1 0 0 1 1 1 0 Presenilin DUF966 PF06136.8 EFX01662.1 - 4 6.7 20.1 0.7 9.2 8.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF966) FemAB PF02388.11 EFX01662.1 - 8.2 4.9 18.8 13 4.3 13.1 1.2 1 0 0 1 1 1 0 FemAB family DUF2146 PF10220.4 EFX01662.1 - 9.3 4.0 14.6 13 3.6 10.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) SIR2 PF02146.12 EFX01664.1 - 3.2e-25 88.9 0.0 1.1e-24 87.1 0.0 1.8 1 1 0 1 1 1 1 Sir2 family AAA_16 PF13191.1 EFX01665.1 - 5.2e-12 46.1 0.1 2.3e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX01665.1 - 3.4e-09 36.9 0.1 8.9e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFX01665.1 - 4.2e-08 33.4 0.0 9.7e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 EFX01665.1 - 0.00051 19.6 0.2 0.0027 17.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX01665.1 - 0.012 15.4 0.7 0.097 12.4 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain RNA_helicase PF00910.17 EFX01665.1 - 0.015 15.5 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Cdc6_C PF09079.6 EFX01665.1 - 0.015 14.9 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 CDC6, C terminal Arch_ATPase PF01637.13 EFX01665.1 - 0.033 13.8 0.0 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 Archaeal ATPase AAA_5 PF07728.9 EFX01665.1 - 0.05 13.3 0.1 0.69 9.6 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 EFX01665.1 - 0.17 11.5 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.17 EFX01665.1 - 0.19 10.5 0.0 0.32 9.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_32 PF13654.1 EFX01665.1 - 0.2 10.2 0.0 0.38 9.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain P53_TAD PF08563.6 EFX01666.1 - 0.24 10.5 0.9 0.42 9.7 0.6 1.4 1 0 0 1 1 1 0 P53 transactivation motif ArfGap PF01412.13 EFX01667.1 - 7.2e-33 112.8 1.0 1.2e-32 112.0 0.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 EFX01667.1 - 1.3e-12 47.8 0.2 5.8e-12 45.7 0.1 2.2 2 0 0 2 2 2 1 PH domain EMP24_GP25L PF01105.19 EFX01667.1 - 0.066 12.9 0.9 1.8 8.2 0.5 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD PH_9 PF15410.1 EFX01667.1 - 0.29 11.3 4.6 0.87 9.7 0.8 3.2 2 1 0 2 2 2 0 Pleckstrin homology domain Methyltransf_25 PF13649.1 EFX01669.1 - 8.7e-10 38.8 0.0 1.8e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX01669.1 - 0.00054 20.3 0.0 0.0012 19.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01669.1 - 0.0097 15.6 0.0 0.017 14.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01669.1 - 0.012 16.1 0.0 0.03 14.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 EFX01669.1 - 0.13 11.8 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF3602 PF12223.3 EFX01670.1 - 4.1e-16 59.1 14.7 9.2e-15 54.8 1.5 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) WBS_methylT PF12589.3 EFX01670.1 - 0.17 12.4 1.7 0.19 12.2 0.3 1.7 2 0 0 2 2 2 0 Methyltransferase involved in Williams-Beuren syndrome Amidohydro_2 PF04909.9 EFX01672.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase Tim54 PF11711.3 EFX01673.1 - 3.4e-87 292.5 0.0 7.4e-87 291.4 0.0 1.5 1 1 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Peptidase_S9 PF00326.16 EFX01674.1 - 2.3e-36 125.0 1.0 2e-35 121.9 0.7 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFX01674.1 - 8.9e-11 41.7 0.3 1.8e-10 40.7 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 EFX01674.1 - 4.4e-07 29.4 0.0 2.3e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 EFX01674.1 - 4.9e-07 29.8 5.8 2e-06 27.8 4.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFX01674.1 - 0.00016 21.3 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.6 EFX01674.1 - 0.0005 19.8 0.2 0.0068 16.1 0.0 2.1 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.11 EFX01674.1 - 0.0021 17.5 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase LIP PF03583.9 EFX01674.1 - 0.005 16.0 0.0 0.0086 15.3 0.0 1.3 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_4 PF08386.5 EFX01674.1 - 0.022 14.6 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein FSH1 PF03959.8 EFX01674.1 - 0.024 14.0 0.0 0.044 13.2 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.15 EFX01674.1 - 0.025 14.1 0.0 0.061 12.8 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase_phd PF10503.4 EFX01674.1 - 0.43 9.7 3.1 4.2 6.5 2.1 2.3 1 1 0 1 1 1 0 Esterase PHB depolymerase Parvo_coat PF00740.13 EFX01676.1 - 0.0015 17.5 0.7 0.0019 17.2 0.5 1.1 1 0 0 1 1 1 1 Parvovirus coat protein VP2 CytochromB561_N PF09786.4 EFX01676.1 - 0.39 9.0 14.3 0.47 8.8 9.9 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal SOBP PF15279.1 EFX01676.1 - 1.6 9.0 6.4 1.9 8.7 4.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF566 PF04484.7 EFX01676.1 - 4.7 6.6 18.3 6.8 6.0 12.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) 2OG-FeII_Oxy PF03171.15 EFX01677.1 - 7.2e-15 55.0 0.0 1.7e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Bac_luciferase PF00296.15 EFX01678.1 - 1.3e-61 208.3 0.0 2e-61 207.8 0.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase Mito_carr PF00153.22 EFX01679.1 - 2.4e-61 203.4 0.0 5.8e-20 70.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF543 PF04418.7 EFX01679.1 - 0.071 13.0 0.7 0.22 11.4 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF543) zf-CSL PF05207.8 EFX01680.1 - 2.4e-15 55.7 0.0 4e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.26 EFX01680.1 - 1.1e-10 41.0 0.0 1.8e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF1348 PF07080.6 EFX01681.1 - 8.8e-50 168.2 2.9 1.4e-49 167.5 2.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.2 EFX01681.1 - 1.5e-07 31.7 1.9 2e-07 31.3 1.1 1.5 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 EFX01681.1 - 0.0013 18.8 0.2 0.0021 18.2 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) ABC_tran PF00005.22 EFX01682.1 - 9.6e-34 116.6 0.0 5.2e-16 59.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFX01682.1 - 2.6e-14 53.8 8.4 0.0058 16.6 0.0 4.8 3 2 2 5 5 5 4 AAA domain RLI PF04068.10 EFX01682.1 - 1.1e-13 50.5 4.8 1.1e-13 50.5 3.3 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.14 EFX01682.1 - 3.4e-11 42.7 0.9 0.0022 17.2 0.0 3.8 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 EFX01682.1 - 6.5e-07 28.7 0.0 2.4 7.1 0.0 4.4 5 0 0 5 5 4 2 AAA ATPase domain AAA PF00004.24 EFX01682.1 - 4e-06 27.0 0.0 0.012 15.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFX01682.1 - 5.9e-06 27.0 0.3 0.17 12.7 0.0 2.9 2 2 0 2 2 2 2 AAA domain Fer4 PF00037.22 EFX01682.1 - 1.4e-05 24.4 1.8 1.4e-05 24.4 1.3 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.1 EFX01682.1 - 1.6e-05 24.3 0.2 0.06 12.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX01682.1 - 2.1e-05 24.8 0.1 0.28 11.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFX01682.1 - 2.6e-05 24.3 0.0 0.0074 16.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFX01682.1 - 0.00011 21.4 1.0 0.76 8.9 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 EFX01682.1 - 0.00024 21.4 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EFX01682.1 - 0.00024 20.8 0.8 0.045 13.4 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B UPF0079 PF02367.12 EFX01682.1 - 0.0004 19.9 0.1 0.007 15.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 VirE PF05272.6 EFX01682.1 - 0.00048 19.6 0.0 1.4 8.3 0.0 2.8 3 0 0 3 3 2 2 Virulence-associated protein E NB-ARC PF00931.17 EFX01682.1 - 0.0007 18.5 0.0 0.054 12.3 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_25 PF13481.1 EFX01682.1 - 0.00083 18.8 0.0 0.56 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EFX01682.1 - 0.00089 19.4 0.3 0.49 10.5 0.0 3.0 3 0 0 3 3 2 1 RNA helicase AAA_16 PF13191.1 EFX01682.1 - 0.0011 18.9 0.1 0.26 11.2 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Fer4_7 PF12838.2 EFX01682.1 - 0.0016 18.7 5.7 0.004 17.4 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Rad17 PF03215.10 EFX01682.1 - 0.002 16.8 0.0 0.07 11.8 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein NACHT PF05729.7 EFX01682.1 - 0.0023 17.6 1.3 0.32 10.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.9 EFX01682.1 - 0.0024 17.5 0.7 0.081 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 EFX01682.1 - 0.0027 17.6 0.5 0.15 11.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_21 PF14697.1 EFX01682.1 - 0.0032 17.3 10.4 0.0064 16.3 7.2 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Thymidylate_kin PF02223.12 EFX01682.1 - 0.0042 16.4 0.6 1.4 8.2 0.0 2.7 3 0 0 3 3 2 1 Thymidylate kinase SRP54 PF00448.17 EFX01682.1 - 0.0091 15.4 2.1 0.34 10.3 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 EFX01682.1 - 0.011 15.6 0.0 0.71 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_6 PF12837.2 EFX01682.1 - 0.011 15.5 1.3 0.011 15.5 0.9 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain AAA_13 PF13166.1 EFX01682.1 - 0.013 13.9 1.0 0.025 13.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain Fer4_8 PF13183.1 EFX01682.1 - 0.017 15.1 6.9 0.045 13.7 4.9 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_30 PF13604.1 EFX01682.1 - 0.022 14.3 0.0 0.6 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 EFX01682.1 - 0.022 15.2 0.0 1.9 9.0 0.0 2.8 3 0 0 3 3 2 0 Miro-like protein Fer4_16 PF13484.1 EFX01682.1 - 0.042 14.6 0.1 0.042 14.6 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_14 PF13173.1 EFX01682.1 - 0.066 13.1 0.4 12 5.8 0.0 3.2 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EFX01682.1 - 0.079 12.6 1.3 4.4 6.9 0.0 2.5 2 0 0 2 2 2 0 NTPase SbcCD_C PF13558.1 EFX01682.1 - 0.14 12.0 0.1 7.1 6.6 0.0 3.2 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.1 EFX01682.1 - 0.24 11.1 1.1 0.59 9.9 0.0 2.1 2 0 0 2 2 1 0 Part of AAA domain AAA_24 PF13479.1 EFX01682.1 - 0.27 10.8 1.0 3.3 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EFX01682.1 - 0.63 9.5 0.0 0.63 9.5 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Fer4_9 PF13187.1 EFX01682.1 - 0.97 9.7 13.8 0.043 14.0 1.6 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_10 PF13237.1 EFX01682.1 - 1.7 8.5 15.1 0.062 13.1 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.2 EFX01682.1 - 3.1 7.9 11.8 0.65 10.0 1.4 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Nop10p PF04135.7 EFX01683.1 - 1.7e-19 69.2 0.2 1.9e-19 69.1 0.1 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family zf-met PF12874.2 EFX01684.1 - 4.4e-06 26.7 1.3 8.5e-06 25.7 0.9 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.4 EFX01684.1 - 0.00061 19.3 0.1 0.00091 18.8 0.0 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein EGF_CA PF07645.10 EFX01684.1 - 0.15 12.1 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Calcium-binding EGF domain Pyrophosphatase PF00719.14 EFX01685.1 - 7.9e-52 174.8 0.1 1.4e-51 174.0 0.1 1.5 1 0 0 1 1 1 1 Inorganic pyrophosphatase Membr_traf_MHD PF10540.4 EFX01685.1 - 9.7e-24 83.7 1.7 1.5e-23 83.1 0.2 2.1 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 EFX01685.1 - 4.4e-17 61.7 0.0 9.2e-17 60.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain Rep_N PF08724.5 EFX01685.1 - 0.055 12.9 0.1 0.17 11.3 0.0 1.8 1 0 0 1 1 1 0 Rep protein catalytic domain like TGF_beta_GS PF08515.7 EFX01685.1 - 0.12 11.7 6.7 0.39 10.1 4.6 1.9 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Nsp1_C PF05064.8 EFX01687.1 - 5.1e-39 132.5 6.8 1.1e-38 131.4 4.7 1.5 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.1 EFX01687.1 - 1.4e-13 51.0 194.2 6.8e-06 26.3 23.9 6.3 1 1 4 5 5 5 4 Nucleoporin FG repeat region Myosin_tail_1 PF01576.14 EFX01687.1 - 0.00059 17.7 10.7 0.001 16.8 3.9 2.0 2 0 0 2 2 2 2 Myosin tail GAS PF13851.1 EFX01687.1 - 0.019 14.1 5.2 2.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding EzrA PF06160.7 EFX01687.1 - 0.054 11.6 8.2 0.34 9.0 0.0 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF16 PF01519.11 EFX01687.1 - 0.22 11.7 3.1 0.46 10.7 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Spc7 PF08317.6 EFX01687.1 - 0.68 8.5 11.4 0.19 10.3 0.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF972 PF06156.8 EFX01687.1 - 0.73 10.2 4.3 3 8.2 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF1664 PF07889.7 EFX01687.1 - 2.5 7.9 6.0 13 5.6 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 EFX01687.1 - 3.6 7.1 10.4 9.8 5.7 7.1 1.8 1 1 0 1 1 1 0 IncA protein YlqD PF11068.3 EFX01687.1 - 3.7 7.5 9.9 4.2 7.4 1.4 2.2 1 1 1 2 2 2 0 YlqD protein AAA_13 PF13166.1 EFX01687.1 - 4.7 5.5 9.2 15 3.9 5.1 1.7 1 1 1 2 2 2 0 AAA domain peroxidase PF00141.18 EFX01688.1 - 2.6e-83 279.0 0.0 6.7e-47 159.8 0.0 2.2 2 0 0 2 2 2 2 Peroxidase HAD_2 PF13419.1 EFX01689.1 - 5.4e-16 59.3 0.0 6.8e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFX01689.1 - 7.3e-11 42.8 0.0 8.1e-09 36.2 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX01689.1 - 1.7e-09 37.2 0.0 3.4e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 EFX01689.1 - 5.6e-06 26.6 0.0 7.4e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase SPDY PF03771.11 EFX01689.1 - 0.054 12.9 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF317) GHL6 PF14871.1 EFX01689.1 - 0.055 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Hydrolase_6 PF13344.1 EFX01689.1 - 0.066 13.1 0.0 0.6 10.0 0.0 2.3 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Med12 PF09497.5 EFX01690.1 - 2.1e-24 85.2 0.3 5.8e-24 83.8 0.2 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med15 PF09606.5 EFX01690.1 - 0.016 13.4 55.4 0.025 12.7 38.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 EFX01690.1 - 2.4 6.3 55.6 3.8 5.6 38.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_UL87 PF03043.9 EFX01690.1 - 4.1 5.6 9.7 6.4 5.0 6.8 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family DUF2277 PF10041.4 EFX01691.1 - 0.19 11.7 0.2 0.39 10.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) NACHT PF05729.7 EFX01692.1 - 1.3e-11 44.4 0.0 3e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EFX01692.1 - 1.4e-07 31.7 1.0 7e-07 29.4 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX01692.1 - 4.2e-05 23.6 0.0 0.00016 21.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain HalX PF08663.5 EFX01692.1 - 0.0052 16.7 0.6 0.035 14.1 0.0 2.7 3 0 0 3 3 3 1 HalX domain AAA PF00004.24 EFX01692.1 - 0.015 15.5 0.0 0.06 13.5 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 EFX01692.1 - 0.025 14.0 0.9 0.53 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain AAA_33 PF13671.1 EFX01692.1 - 0.029 14.2 0.1 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EFX01692.1 - 0.081 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Dict-STAT-coil PF09267.5 EFX01692.1 - 0.12 12.5 0.9 6.7 6.9 0.5 2.6 1 1 0 2 2 2 0 Dictyostelium STAT, coiled coil Med16 PF11635.3 EFX01693.1 - 1.2e-105 354.2 0.2 1.7e-105 353.7 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 Lum_binding PF00677.12 EFX01693.1 - 1.3e-35 121.0 0.0 1.5e-16 60.0 0.0 3.2 3 0 0 3 3 3 2 Lumazine binding domain Chorismate_synt PF01264.16 EFX01694.1 - 5.1e-129 429.6 0.0 6e-129 429.4 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase COesterase PF00135.23 EFX01695.1 - 2.7e-101 339.9 0.0 3.3e-101 339.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX01695.1 - 3.6e-10 39.7 0.1 9.2e-10 38.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFX01695.1 - 0.016 14.4 0.0 0.035 13.3 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFX01695.1 - 0.017 14.8 0.2 0.037 13.7 0.2 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family RRM_1 PF00076.17 EFX01696.1 - 1.5e-18 66.1 0.2 2.8e-18 65.3 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01696.1 - 8.1e-13 48.1 0.0 1.7e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01696.1 - 3e-09 36.5 0.2 4.8e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DLH PF01738.13 EFX01697.1 - 5.9e-29 100.9 0.1 6.7e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFX01697.1 - 0.00049 19.8 0.0 0.00067 19.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF202 PF02656.10 EFX01699.1 - 0.032 14.4 1.1 0.032 14.4 0.8 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Cation_ATPase_C PF00689.16 EFX01699.1 - 5.9 6.3 15.4 76 2.7 10.7 2.2 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus AAA_16 PF13191.1 EFX01700.1 - 5.9e-08 32.9 3.2 1.4e-07 31.7 0.1 3.3 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 EFX01700.1 - 8.4e-07 28.7 0.0 2.9e-06 27.0 0.0 2.0 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EFX01700.1 - 0.0004 20.5 0.0 0.0046 17.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain TPR_7 PF13176.1 EFX01700.1 - 0.00053 19.5 12.2 1.5 8.8 0.1 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat AAA_19 PF13245.1 EFX01700.1 - 0.00086 19.0 0.0 0.00086 19.0 0.0 3.2 3 0 0 3 3 3 1 Part of AAA domain AAA PF00004.24 EFX01700.1 - 0.0085 16.2 0.5 0.15 12.2 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) TPR_6 PF13174.1 EFX01700.1 - 0.22 12.0 3.3 17 6.1 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFX01700.1 - 7 6.7 24.9 29 4.7 0.0 8.4 9 0 0 9 9 9 0 Tetratricopeptide repeat MFS_1 PF07690.11 EFX01701.1 - 8.3e-12 44.4 14.5 1.5e-11 43.6 10.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily RhoGEF PF00621.15 EFX01702.1 - 1.6e-30 106.3 0.0 4.1e-30 104.9 0.0 1.7 2 0 0 2 2 2 1 RhoGEF domain BAR PF03114.13 EFX01702.1 - 9.8e-12 44.8 4.0 5e-11 42.5 1.9 2.6 2 1 0 2 2 2 1 BAR domain Prenyltrans PF00432.16 EFX01703.1 - 3.3e-29 100.1 2.2 6.3e-09 35.2 0.2 3.9 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 EFX01703.1 - 7.7e-23 80.5 3.1 1.7e-10 40.8 0.1 6.1 3 2 5 8 8 8 4 Prenyltransferase-like Prenyltrans_2 PF13249.1 EFX01703.1 - 1.4e-19 70.5 3.2 7e-12 45.7 0.1 5.0 4 1 2 6 6 6 4 Prenyltransferase-like Pec_lyase PF09492.5 EFX01703.1 - 0.00081 18.6 0.2 3.6 6.6 0.0 4.4 4 2 1 5 5 5 2 Pectic acid lyase Flavin_Reduct PF01613.13 EFX01705.1 - 9.4e-09 35.3 0.0 9.9e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain DUF447 PF04289.7 EFX01705.1 - 0.003 17.1 0.0 0.0036 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF447) Pyridox_oxidase PF01243.15 EFX01705.1 - 0.0058 16.6 0.0 0.0081 16.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase AAA PF00004.24 EFX01706.1 - 1.9e-16 60.4 0.0 8.5e-16 58.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFX01706.1 - 0.0002 21.0 0.1 0.00061 19.4 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EFX01706.1 - 0.0021 18.0 0.5 0.012 15.6 0.1 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX01706.1 - 0.0024 18.0 0.6 0.013 15.6 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EFX01706.1 - 0.009 15.7 0.0 0.021 14.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 EFX01706.1 - 0.01 15.4 0.1 0.021 14.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EFX01706.1 - 0.03 14.2 0.1 0.069 13.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 EFX01706.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 EFX01706.1 - 0.12 11.4 0.3 0.88 8.6 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Torsin PF06309.6 EFX01706.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Torsin HET PF06985.6 EFX01707.1 - 0.0012 18.9 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Radical_SAM PF04055.16 EFX01708.1 - 5.8e-11 42.8 0.1 2e-10 41.1 0.1 1.9 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 EFX01708.1 - 1.9e-06 27.9 0.6 4.7e-06 26.6 0.1 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EFX01708.1 - 2.1e-06 27.9 0.3 4.6e-06 26.7 0.2 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain SNF2_N PF00176.18 EFX01709.1 - 5.8e-63 212.4 0.0 9.5e-63 211.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 EFX01709.1 - 1.7e-26 91.6 2.2 6.2e-14 51.4 0.1 3.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 EFX01709.1 - 8.3e-15 54.4 0.0 2.4e-14 52.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFX01709.1 - 0.067 13.3 0.0 0.26 11.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain Zn_clus PF00172.13 EFX01710.1 - 1e-07 31.7 7.3 2.1e-07 30.7 5.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX01710.1 - 1.3e-06 27.4 1.0 2.6e-06 26.5 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_transf_90 PF05686.7 EFX01711.1 - 1.9e-10 40.0 0.1 5.8e-09 35.1 0.0 2.6 3 0 0 3 3 3 2 Glycosyl transferase family 90 MBOAT_2 PF13813.1 EFX01712.1 - 2.3e-14 53.2 4.0 2.3e-14 53.2 2.8 2.4 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family NMT1 PF09084.6 EFX01712.1 - 3.2e-07 30.1 0.1 4.6e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 EFX01712.1 - 0.026 13.8 0.2 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 NMT1-like family FolB PF02152.13 EFX01713.1 - 9.1e-23 80.5 0.0 6.7e-20 71.3 0.1 2.3 2 0 0 2 2 2 2 Dihydroneopterin aldolase Pyr_redox_3 PF13738.1 EFX01714.1 - 1.5e-18 67.5 0.1 3.8e-18 66.3 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX01714.1 - 2e-08 34.3 0.0 3.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFX01714.1 - 1.3e-07 31.0 0.4 0.00038 19.6 0.1 2.2 1 1 1 2 2 2 2 FAD binding domain K_oxygenase PF13434.1 EFX01714.1 - 5.1e-06 25.6 0.3 8.7e-05 21.5 0.1 2.7 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.14 EFX01714.1 - 0.00099 17.4 0.0 0.0032 15.7 0.0 1.7 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX01714.1 - 0.0053 16.7 0.0 0.018 15.0 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX01714.1 - 0.0068 16.2 1.6 13 5.5 0.5 3.2 2 1 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 EFX01714.1 - 0.012 14.5 1.0 0.014 14.3 0.1 1.7 2 1 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.12 EFX01714.1 - 0.022 13.8 0.0 0.051 12.6 0.0 1.5 1 0 0 1 1 1 0 Thi4 family DUF4440 PF14534.1 EFX01714.1 - 0.034 14.3 0.1 0.082 13.1 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) SnoaL_3 PF13474.1 EFX01714.1 - 0.051 13.6 0.4 1.3 9.0 0.1 2.8 2 1 0 2 2 2 0 SnoaL-like domain HI0933_like PF03486.9 EFX01714.1 - 0.064 11.7 0.1 0.1 11.0 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein 2-Hacid_dh_C PF02826.14 EFX01714.1 - 0.11 11.6 0.0 1.3 8.1 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 EFX01714.1 - 0.98 8.1 5.3 0.22 10.3 0.1 2.4 3 1 0 3 3 3 0 FAD binding domain Pyr_redox_3 PF13738.1 EFX01715.1 - 4.9e-23 82.2 0.0 9.2e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX01715.1 - 7.6e-18 63.9 0.1 1.2e-16 60.0 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX01715.1 - 1.4e-09 37.7 0.1 4.5e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX01715.1 - 4.4e-08 32.4 0.0 1.8e-05 23.8 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EFX01715.1 - 7.8e-08 32.4 0.0 3.2e-05 23.8 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX01715.1 - 3.3e-05 23.7 0.8 0.0067 16.2 0.0 3.7 3 1 0 3 3 3 1 FAD-NAD(P)-binding Malic_M PF03949.10 EFX01715.1 - 0.0051 16.4 0.0 2.9 7.3 0.0 2.9 4 0 0 4 4 4 2 Malic enzyme, NAD binding domain TrmE_N PF10396.4 EFX01716.1 - 3.2e-34 117.3 0.0 9.3e-34 115.8 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus GTPase_Cys_C PF12631.2 EFX01716.1 - 3.1e-19 69.1 2.4 4.5e-19 68.6 0.0 2.6 3 0 0 3 3 3 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE MMR_HSR1 PF01926.18 EFX01716.1 - 3.1e-14 52.9 0.0 5.2e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFX01716.1 - 0.00016 21.5 0.0 0.0003 20.6 0.0 1.4 1 1 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 EFX01716.1 - 0.00051 19.3 0.0 0.0012 18.1 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B Glyco_hydro_3_C PF01915.17 EFX01716.1 - 0.0058 16.1 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain ABC_tran PF00005.22 EFX01716.1 - 0.059 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF258 PF03193.11 EFX01716.1 - 0.059 12.5 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 PGK PF00162.14 EFX01717.1 - 3.1e-151 503.3 0.1 3.5e-151 503.1 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase FIVAR PF07554.8 EFX01717.1 - 0.0028 17.8 3.1 0.48 10.7 0.0 4.3 4 0 0 4 4 4 1 Uncharacterised Sugar-binding Domain AAA PF00004.24 EFX01719.1 - 8.8e-41 139.2 0.0 1.5e-40 138.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX01719.1 - 4.2e-06 26.9 0.0 0.00051 20.1 0.0 2.9 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.9 EFX01719.1 - 9.8e-06 25.3 0.1 5.7e-05 22.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFX01719.1 - 9.7e-05 22.4 0.1 0.00037 20.5 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 EFX01719.1 - 0.00036 20.5 0.0 0.00096 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EFX01719.1 - 0.0008 18.4 0.0 0.0015 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 EFX01719.1 - 0.0021 18.8 0.6 0.0047 17.7 0.1 2.1 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.1 EFX01719.1 - 0.0025 17.5 0.2 0.0067 16.1 0.1 1.7 2 0 0 2 2 1 1 Part of AAA domain RuvB_N PF05496.7 EFX01719.1 - 0.0037 16.3 0.0 0.0065 15.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 EFX01719.1 - 0.0085 16.0 0.1 0.019 14.8 0.0 1.6 2 0 0 2 2 1 1 AAA domain Sigma54_activ_2 PF14532.1 EFX01719.1 - 0.0096 15.9 0.0 0.035 14.1 0.0 2.0 2 0 0 2 2 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 EFX01719.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 EFX01719.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFX01719.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EFX01719.1 - 0.02 14.4 0.1 0.57 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 EFX01719.1 - 0.024 14.3 0.3 5.6 6.5 0.0 2.7 2 1 1 3 3 3 0 Archaeal ATPase AAA_3 PF07726.6 EFX01719.1 - 0.027 14.0 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EFX01719.1 - 0.03 13.7 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 EFX01719.1 - 0.031 14.4 0.0 0.081 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 EFX01719.1 - 0.044 14.0 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 EFX01719.1 - 0.044 12.5 0.0 0.08 11.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 EFX01719.1 - 0.049 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFX01719.1 - 0.052 12.7 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EFX01719.1 - 0.085 12.3 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain KaiC PF06745.8 EFX01719.1 - 0.086 11.9 0.0 1.6 7.8 0.0 2.4 2 0 0 2 2 2 0 KaiC DUF2291 PF10054.4 EFX01719.1 - 0.088 12.0 0.6 0.27 10.4 0.0 1.8 2 0 0 2 2 2 0 Predicted periplasmic lipoprotein (DUF2291) WD40 PF00400.27 EFX01720.1 - 4.4e-05 23.1 1.4 8.6 6.4 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat PD40 PF07676.7 EFX01720.1 - 0.052 13.2 0.0 0.26 10.9 0.0 2.2 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Sec20 PF03908.8 EFX01722.1 - 6.9e-08 32.0 0.0 2e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 Sec20 Methyltransf_17 PF12692.2 EFX01722.1 - 0.069 12.8 0.8 0.12 12.0 0.2 1.7 2 0 0 2 2 2 0 S-adenosyl-L-methionine methyltransferase DUF3365 PF11845.3 EFX01722.1 - 0.15 11.9 1.9 8.4 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) NOA36 PF06524.7 EFX01722.1 - 1.2 8.2 3.9 2.4 7.3 2.7 1.4 1 0 0 1 1 1 0 NOA36 protein Syntaxin PF00804.20 EFX01722.1 - 1.8 8.7 9.0 0.17 12.0 1.0 2.5 2 1 0 2 2 2 0 Syntaxin Sporozoite_P67 PF05642.6 EFX01722.1 - 7.7 4.2 12.8 1.3 6.7 1.8 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen CYTH PF01928.16 EFX01723.1 - 9.7e-12 44.9 0.1 1.4e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 CYTH domain Mso1_Sec1_bdg PF14475.1 EFX01724.1 - 4.7e-19 67.4 0.0 7.2e-19 66.9 0.0 1.3 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Amidohydro_1 PF01979.15 EFX01725.1 - 5.8e-12 45.9 1.4 9e-09 35.4 1.0 2.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EFX01725.1 - 1.1e-09 37.9 0.5 2.9e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_4 PF13147.1 EFX01725.1 - 2.5e-09 37.5 8.4 3.3e-06 27.3 3.6 2.3 1 1 1 2 2 2 2 Amidohydrolase Amidohydro_3 PF07969.6 EFX01725.1 - 0.015 14.5 3.9 0.048 12.8 0.6 2.5 1 1 1 2 2 2 0 Amidohydrolase family Ank_2 PF12796.2 EFX01726.1 - 1.2e-35 121.7 3.3 1.3e-09 38.2 0.1 4.3 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01726.1 - 5.3e-22 76.4 20.3 1.9e-05 24.2 0.0 9.2 9 0 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.1 EFX01726.1 - 2e-18 66.3 8.7 3e-06 27.5 0.1 5.6 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX01726.1 - 1.3e-17 62.1 12.4 0.00038 20.4 0.0 8.8 10 0 0 10 10 10 4 Ankyrin repeat Ank_5 PF13857.1 EFX01726.1 - 6.7e-16 57.9 14.4 0.00018 21.6 0.0 6.7 3 3 2 6 6 6 5 Ankyrin repeats (many copies) Cnd2 PF05786.9 EFX01727.1 - 6.2e-202 672.9 0.0 9.3e-202 672.4 0.0 1.2 1 0 0 1 1 1 1 Condensin complex subunit 2 MFS_1 PF07690.11 EFX01728.1 - 7.1e-42 143.3 25.8 7.1e-42 143.3 17.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.13 EFX01728.1 - 0.0035 16.2 0.0 0.0091 14.9 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain PRMT5 PF05185.11 EFX01730.1 - 5.1e-12 45.4 0.1 7.1e-12 44.9 0.1 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_31 PF13847.1 EFX01730.1 - 3.3e-11 43.0 0.1 5e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFX01730.1 - 7.6e-11 41.6 0.1 1.2e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 EFX01730.1 - 4.1e-08 33.6 0.0 8.5e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01730.1 - 1e-07 32.4 0.0 2.1e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EFX01730.1 - 4.7e-07 28.8 0.1 7e-07 28.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_26 PF13659.1 EFX01730.1 - 5e-07 29.7 0.0 1.1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX01730.1 - 2.2e-05 24.7 0.0 5.1e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01730.1 - 0.0001 22.0 0.0 0.00018 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFX01730.1 - 0.00028 20.0 0.0 0.00039 19.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 EFX01730.1 - 0.00029 21.2 0.0 0.00055 20.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX01730.1 - 0.00056 19.3 0.1 0.00095 18.5 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 EFX01730.1 - 0.055 13.1 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF3661 PF12400.3 EFX01731.1 - 3.7e-42 143.4 2.3 6.1e-42 142.7 1.6 1.4 1 0 0 1 1 1 1 Vaculolar membrane protein HSP70 PF00012.15 EFX01732.1 - 2.7e-05 22.3 0.0 5.3e-05 21.3 0.0 1.5 1 0 0 1 1 1 1 Hsp70 protein TPP_enzyme_N PF02776.13 EFX01733.1 - 7.6e-51 172.0 0.0 7e-50 168.8 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EFX01733.1 - 2.1e-50 170.2 1.1 9e-49 164.9 0.0 3.2 3 1 1 4 4 4 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EFX01733.1 - 3.3e-36 124.0 0.4 8.1e-36 122.8 0.1 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.14 EFX01733.1 - 0.017 14.6 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg His_Phos_2 PF00328.17 EFX01735.1 - 8.8e-06 25.2 0.0 4.9e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.17 EFX01736.1 - 3.1e-29 102.3 0.0 3.9e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.17 EFX01736.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) Oxidored_FMN PF00724.15 EFX01738.1 - 1.2e-88 297.4 0.0 1.3e-88 297.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family SNF2_N PF00176.18 EFX01739.1 - 5.4e-12 45.1 0.0 6.5e-11 41.5 0.0 2.5 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.10 EFX01739.1 - 0.0005 19.9 0.3 0.023 14.5 0.2 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFX01739.1 - 0.0013 18.2 0.0 0.0063 16.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase FLO_LFY PF01698.11 EFX01739.1 - 3.9 6.2 7.5 4.4 6.0 0.5 2.5 2 0 0 2 2 2 0 Floricaula / Leafy protein MFS_1 PF07690.11 EFX01740.1 - 8.1e-21 74.1 31.1 8.1e-21 74.1 21.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Ldr_toxin PF13940.1 EFX01740.1 - 0.017 14.8 0.1 0.072 12.8 0.0 2.2 1 0 0 1 1 1 0 Toxin Ldr, type I toxin-antitoxin system MFS_1 PF07690.11 EFX01741.1 - 4.3e-36 124.3 28.5 6.2e-36 123.8 19.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily ASFV_J13L PF05568.6 EFX01741.1 - 0.0089 15.5 0.1 0.016 14.7 0.1 1.3 1 0 0 1 1 1 1 African swine fever virus J13L protein GPAT_N PF14829.1 EFX01741.1 - 0.058 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal Ada_Zn_binding PF02805.11 EFX01742.1 - 2.1e-28 97.6 7.1 4.3e-28 96.7 4.9 1.5 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_18 PF12833.2 EFX01742.1 - 5.6e-08 32.7 0.1 1.1e-07 31.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.18 EFX01742.1 - 2.9e-07 30.0 0.0 5.5e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family Velvet PF11754.3 EFX01743.1 - 2.4e-72 242.8 0.6 4.8e-72 241.8 0.0 1.6 2 0 0 2 2 2 1 Velvet factor DUF2360 PF10152.4 EFX01743.1 - 0.64 10.2 4.9 10 6.3 3.4 2.2 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) HAMP PF00672.20 EFX01744.1 - 1.3e-46 156.5 17.0 5e-10 39.4 0.2 7.0 6 0 0 6 6 6 6 HAMP domain HATPase_c PF02518.21 EFX01744.1 - 2.5e-30 104.4 0.6 6.1e-30 103.2 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EFX01744.1 - 5.6e-28 97.1 0.5 6.3e-27 93.8 0.3 2.6 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 EFX01744.1 - 1.5e-17 63.3 0.6 1.5e-17 63.3 0.4 4.1 5 0 0 5 5 5 1 His Kinase A (phospho-acceptor) domain DUF883 PF05957.8 EFX01744.1 - 0.0037 17.6 7.4 2.6 8.5 0.1 5.4 3 2 3 6 6 6 1 Bacterial protein of unknown function (DUF883) AAA_13 PF13166.1 EFX01744.1 - 0.028 12.9 14.1 0.41 9.0 0.1 3.7 1 1 2 4 4 4 0 AAA domain DUF2365 PF10157.4 EFX01744.1 - 0.037 13.9 13.6 2.9 7.7 0.1 6.3 5 1 0 6 6 6 0 Uncharacterized conserved protein (DUF2365) NAAA-beta PF15508.1 EFX01744.1 - 0.46 10.8 3.9 22 5.5 0.1 5.0 4 2 0 5 5 5 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase PAF-AH_p_II PF03403.8 EFX01745.1 - 1.6e-40 138.6 0.0 4e-35 120.8 0.0 2.3 2 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.2 EFX01745.1 - 4.4e-10 39.4 0.1 1e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 EFX01745.1 - 0.00065 18.6 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.6 EFX01745.1 - 0.0043 15.9 0.0 0.0069 15.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase DLH PF01738.13 EFX01745.1 - 0.056 12.7 0.0 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF3617 PF12276.3 EFX01746.1 - 0.06 12.7 0.4 0.2 11.0 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) MFS_1 PF07690.11 EFX01749.1 - 2.2e-29 102.3 30.0 2.2e-29 102.3 20.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX01749.1 - 7e-11 41.3 7.5 7e-11 41.3 5.2 2.4 2 2 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFX01749.1 - 0.00093 17.5 0.2 0.0014 16.9 0.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ank_4 PF13637.1 EFX01750.1 - 4.5e-24 84.3 4.7 3.1e-10 40.2 0.0 5.9 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX01750.1 - 7.8e-23 80.6 0.4 1.7e-09 37.8 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01750.1 - 2.5e-17 61.7 5.0 2.6e-07 30.1 0.0 6.5 5 1 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 EFX01750.1 - 1.8e-14 52.3 3.4 2.4e-06 27.2 0.0 6.8 8 0 0 8 8 8 2 Ankyrin repeat Ank_5 PF13857.1 EFX01750.1 - 1.2e-13 50.8 8.7 2.7e-08 33.7 0.1 4.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) MRP_L53 PF10780.4 EFX01751.1 - 1e-19 70.1 0.2 1.6e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 TauD PF02668.11 EFX01752.1 - 5.4e-52 177.0 0.8 8.3e-52 176.4 0.5 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 EFX01752.1 - 6.4e-05 21.9 0.0 0.00015 20.7 0.0 1.4 1 1 0 1 1 1 1 CsiD 2OG-FeII_Oxy_3 PF13640.1 EFX01752.1 - 0.0081 16.6 0.1 0.024 15.1 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF971 PF06155.7 EFX01752.1 - 0.057 13.8 0.1 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF971) Na_Ca_ex PF01699.19 EFX01753.1 - 2.1e-43 147.3 40.2 5.7e-22 77.8 9.3 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Zip PF02535.17 EFX01753.1 - 1.9e-05 23.8 4.2 5.1e-05 22.4 0.3 2.7 2 0 0 2 2 2 1 ZIP Zinc transporter Neur_chan_memb PF02932.11 EFX01753.1 - 0.0027 17.6 0.1 0.0027 17.6 0.1 2.1 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF3784 PF12650.2 EFX01753.1 - 3.6 7.5 8.9 9.4 6.2 1.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Packaging_FI PF14000.1 EFX01753.1 - 3.7 7.7 13.3 3.1 7.9 1.7 3.2 3 0 0 3 3 3 0 DNA packaging protein FI AA_permease_2 PF13520.1 EFX01754.1 - 2.5e-61 207.5 44.4 3.2e-61 207.1 30.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX01754.1 - 4.6e-18 64.8 32.7 4.6e-18 64.8 22.7 1.4 1 1 0 1 1 1 1 Amino acid permease Catalase PF00199.14 EFX01755.1 - 4e-134 447.1 0.5 1.5e-80 270.8 0.2 2.1 1 1 1 2 2 2 2 Catalase Fungal_trans_2 PF11951.3 EFX01755.1 - 8e-19 67.4 4.4 1.1e-18 66.9 3.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MOSC PF03473.12 EFX01756.1 - 1.4e-20 73.1 0.0 2.8e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.11 EFX01756.1 - 2.7e-20 72.2 0.0 9.2e-20 70.5 0.0 2.0 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.14 EFX01756.1 - 9.1e-20 70.7 0.0 8.7e-13 47.7 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V PMM PF03332.8 EFX01757.1 - 5.4e-102 340.0 0.1 6.2e-102 339.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 EFX01757.1 - 0.00028 20.5 0.0 0.0044 16.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFX01757.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase GTP_EFTU PF00009.22 EFX01758.1 - 9.1e-38 129.5 0.1 1.6e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 EFX01758.1 - 7.6e-36 122.0 0.3 1.8e-35 120.8 0.2 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 EFX01758.1 - 3.3e-10 39.9 0.3 8.7e-10 38.5 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX01758.1 - 0.026 14.4 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFX01758.1 - 0.1 12.4 0.0 0.46 10.2 0.0 2.1 3 0 0 3 3 3 0 Dynamin family MFS_1 PF07690.11 EFX01759.1 - 1.1e-08 34.1 18.1 1.3e-08 34.0 11.0 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily ATP-synt_B PF00430.13 EFX01759.1 - 0.062 13.0 0.5 0.19 11.5 0.4 1.7 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) DUF3094 PF11293.3 EFX01759.1 - 3.5 7.1 7.2 1.2 8.6 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3094) DUF4185 PF13810.1 EFX01760.1 - 3.8e-06 26.0 0.0 6.7e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) ATP_synt_I PF03899.10 EFX01760.1 - 0.029 14.5 0.3 0.029 14.5 0.2 2.5 3 1 0 3 3 3 0 ATP synthase I chain DAO PF01266.19 EFX01761.1 - 3.2e-41 141.4 1.1 4.7e-41 140.8 0.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX01761.1 - 0.012 15.5 5.2 0.038 14.0 0.0 3.8 4 0 0 4 4 4 0 NAD(P)-binding Rossmann-like domain ETX_MTX2 PF03318.8 EFX01762.1 - 0.00012 21.6 14.1 0.00013 21.6 8.8 1.5 1 1 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Ribosomal_L35p PF01632.14 EFX01763.1 - 0.022 14.6 0.8 0.041 13.7 0.5 1.4 1 0 0 1 1 1 0 Ribosomal protein L35 ABC_tran PF00005.22 EFX01765.1 - 1.7e-12 47.8 0.0 2.4e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.13 EFX01765.1 - 0.00013 21.5 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF87 PF01935.12 EFX01765.1 - 0.0015 18.3 0.1 0.0064 16.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_29 PF13555.1 EFX01765.1 - 0.0027 17.1 0.4 0.0067 15.9 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SE PF00437.15 EFX01765.1 - 0.011 14.6 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.1 EFX01765.1 - 0.012 16.3 0.2 0.032 15.0 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.1 EFX01765.1 - 0.028 14.7 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFX01765.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Glyco_tranf_2_3 PF13641.1 EFX01766.1 - 4e-18 66.0 0.4 1.1e-17 64.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EFX01766.1 - 2.7e-12 46.3 0.2 0.0002 20.7 0.0 3.5 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EFX01766.1 - 0.00097 18.8 0.0 0.047 13.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 CoA_transf_3 PF02515.12 EFX01767.1 - 2.5e-56 189.9 0.0 1.9e-55 187.0 0.0 2.2 2 0 0 2 2 2 1 CoA-transferase family III ADH_N PF08240.7 EFX01768.1 - 1e-05 25.2 0.1 2.2e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX01768.1 - 2.5e-05 23.8 0.0 6.6e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FR47 PF08445.5 EFX01769.1 - 4.4e-05 23.1 0.0 0.00035 20.2 0.0 2.3 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EFX01769.1 - 0.00011 22.2 0.0 0.0003 20.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FF PF01846.14 EFX01770.1 - 1.9e-51 171.7 0.9 8e-12 44.9 0.0 5.7 5 0 0 5 5 5 5 FF domain WW PF00397.21 EFX01770.1 - 3.6e-19 68.2 10.9 3.6e-10 39.5 0.4 2.5 2 0 0 2 2 2 2 WW domain B12-binding_2 PF02607.12 EFX01770.1 - 0.025 14.6 0.2 7.6 6.6 0.1 2.7 2 0 0 2 2 2 0 B12 binding domain RRM_1 PF00076.17 EFX01771.1 - 2.1e-20 72.1 0.0 4e-11 42.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01771.1 - 1.2e-15 57.1 0.1 3e-08 33.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01771.1 - 2.6e-10 39.9 0.0 3.2e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_2_N PF02837.13 EFX01772.1 - 0.0019 17.7 0.0 0.0058 16.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF3119 PF11317.3 EFX01772.1 - 0.087 12.8 0.4 0.17 11.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) Cyclin PF08613.6 EFX01773.1 - 6.4e-13 49.3 0.0 9.8e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EFX01773.1 - 0.00054 19.5 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain CBFD_NFYB_HMF PF00808.18 EFX01775.1 - 9.1e-10 38.4 0.0 1.7e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFX01775.1 - 1.7e-05 24.8 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TPR_11 PF13414.1 EFX01777.1 - 2.3e-09 36.7 2.9 1.1e-08 34.5 0.3 3.0 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 EFX01777.1 - 1.3e-05 24.7 2.4 1 9.4 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFX01777.1 - 7.8e-05 22.1 1.9 0.23 11.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat DnaJ PF00226.26 EFX01777.1 - 0.0027 17.4 0.3 0.007 16.0 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain TPR_12 PF13424.1 EFX01777.1 - 0.011 15.6 0.8 0.011 15.6 0.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat UBA PF00627.26 EFX01777.1 - 0.051 13.4 0.7 0.13 12.1 0.1 2.0 2 0 0 2 2 2 0 UBA/TS-N domain DUF1880 PF08976.6 EFX01777.1 - 0.42 10.7 6.9 4.1 7.5 4.8 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1880) TPR_12 PF13424.1 EFX01778.1 - 0.00012 21.8 4.2 0.0046 16.8 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat Ank_4 PF13637.1 EFX01778.1 - 0.006 17.0 0.0 0.02 15.4 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX01778.1 - 0.011 16.0 0.0 0.029 14.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) TPR_16 PF13432.1 EFX01778.1 - 0.015 15.9 0.4 0.015 15.9 0.3 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ADH_zinc_N PF00107.21 EFX01779.1 - 3.8e-18 65.3 4.1 8.3e-18 64.1 2.9 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX01779.1 - 5.4e-18 64.7 0.1 1.8e-17 63.1 0.1 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EFX01779.1 - 4.5e-08 34.0 1.4 3.5e-07 31.1 0.1 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 EFX01779.1 - 7.9e-05 22.2 2.3 8.1e-05 22.2 0.6 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.10 EFX01779.1 - 0.0035 17.2 0.8 0.0075 16.1 0.3 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 EFX01779.1 - 0.0092 15.1 0.1 0.018 14.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FLgD_tudor PF13861.1 EFX01779.1 - 0.077 13.0 1.5 0.92 9.5 0.1 2.8 2 0 0 2 2 2 0 FlgD Tudor-like domain Met_10 PF02475.11 EFX01779.1 - 0.14 11.6 0.7 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 Met-10+ like-protein Methyltransf_26 PF13659.1 EFX01779.1 - 6.5 6.8 9.6 0.11 12.4 0.7 2.3 2 2 0 2 2 2 0 Methyltransferase domain adh_short PF00106.20 EFX01780.1 - 8.5e-16 58.3 0.4 1.4e-15 57.6 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX01780.1 - 8.2e-08 32.1 0.3 1.5e-07 31.2 0.2 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX01780.1 - 0.0036 16.7 0.1 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX01780.1 - 0.0046 16.9 0.1 0.015 15.3 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding adh_short_C2 PF13561.1 EFX01780.1 - 0.075 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase CRC_subunit PF08624.5 EFX01781.1 - 4.5e-55 185.3 0.0 6.1e-55 184.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit CFEM PF05730.6 EFX01782.1 - 2.1e-09 37.0 6.0 2.1e-09 37.0 4.2 1.7 1 1 0 1 1 1 1 CFEM domain Fungal_trans_2 PF11951.3 EFX01783.1 - 0.067 11.7 0.0 0.08 11.5 0.0 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain Pkinase PF00069.20 EFX01784.1 - 2.7e-63 213.5 0.1 2.3e-41 141.6 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX01784.1 - 3.9e-34 117.8 0.0 6.3e-25 87.7 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFX01784.1 - 2.2e-05 23.5 0.0 0.096 11.6 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.6 EFX01784.1 - 0.13 11.1 0.0 0.26 10.0 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 adh_short PF00106.20 EFX01785.1 - 4.5e-16 59.2 1.7 1.1e-12 48.1 0.0 2.5 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01785.1 - 7.4e-15 55.3 0.0 1.7e-14 54.1 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Hist_deacetyl PF00850.14 EFX01786.1 - 2.3e-76 257.0 0.0 3.7e-76 256.3 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain SR-25 PF10500.4 EFX01787.1 - 5.5 6.3 9.4 8.8 5.7 6.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIB PF00382.14 EFX01788.1 - 1e-31 108.5 0.2 1.2e-17 63.5 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EFX01788.1 - 5.3e-13 48.0 1.2 5.3e-13 48.0 0.8 1.9 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_N PF00134.18 EFX01788.1 - 0.017 14.6 0.0 4.1 6.9 0.0 2.3 2 0 0 2 2 2 0 Cyclin, N-terminal domain Cyclin_C PF02984.14 EFX01788.1 - 0.027 14.3 0.1 3.5 7.5 0.0 2.6 1 1 1 2 2 2 0 Cyclin, C-terminal domain DUF1216 PF06746.6 EFX01788.1 - 0.12 12.1 1.1 0.53 10.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) PhnA_Zn_Ribbon PF08274.7 EFX01788.1 - 0.49 10.2 3.1 4.5 7.1 0.2 2.6 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-ribbon_3 PF13248.1 EFX01788.1 - 0.54 9.5 3.6 2.6 7.3 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Ras PF00071.17 EFX01789.1 - 1.2e-50 171.0 0.0 1.4e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX01789.1 - 3.1e-15 56.7 0.0 4.3e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX01789.1 - 4.9e-07 29.1 0.0 7.2e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFX01789.1 - 0.0011 18.1 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EFX01789.1 - 0.014 14.8 0.0 1.1 8.6 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 EFX01789.1 - 0.027 13.6 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EFX01789.1 - 0.04 13.8 0.0 0.063 13.2 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 EFX01789.1 - 0.061 13.2 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain PXA PF02194.10 EFX01790.1 - 7.9e-45 152.6 3.6 9.3e-45 152.4 0.0 2.7 3 0 0 3 3 3 1 PXA domain Nexin_C PF08628.7 EFX01790.1 - 4.1e-23 81.6 1.4 9.9e-23 80.3 0.0 2.4 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.19 EFX01790.1 - 2.5e-19 69.1 0.0 6.5e-19 67.7 0.0 1.8 1 0 0 1 1 1 1 PX domain RGS PF00615.14 EFX01790.1 - 8.3e-10 38.7 0.0 2.8e-09 37.1 0.0 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain HET PF06985.6 EFX01791.1 - 0.002 18.2 0.0 0.006 16.7 0.0 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TIR_2 PF13676.1 EFX01791.1 - 0.019 15.0 0.1 0.054 13.6 0.0 1.8 2 0 0 2 2 2 0 TIR domain GMC_oxred_N PF00732.14 EFX01792.1 - 1.3e-58 198.4 0.0 2.4e-58 197.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX01792.1 - 8.5e-23 81.2 0.0 1.9e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EFX01792.1 - 5.6e-07 28.7 0.9 0.0057 15.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 EFX01792.1 - 6.7e-06 25.2 0.0 0.0033 16.3 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFX01792.1 - 0.002 17.1 0.2 0.0035 16.2 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFX01792.1 - 0.0059 16.5 0.1 0.014 15.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFX01792.1 - 0.12 12.1 0.0 0.52 10.1 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX01792.1 - 0.16 10.4 0.2 0.29 9.5 0.1 1.5 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.12 EFX01792.1 - 0.19 10.8 0.1 0.33 10.0 0.1 1.3 1 0 0 1 1 1 0 Thi4 family YchF-GTPase_C PF06071.8 EFX01793.1 - 2.8e-37 126.3 0.1 7.1e-37 125.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 EFX01793.1 - 4.2e-18 65.4 0.0 6.6e-18 64.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX01793.1 - 7.2e-09 35.1 0.0 1.4e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Aldedh PF00171.17 EFX01794.1 - 1.7e-104 349.7 0.9 2.1e-104 349.4 0.6 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family UbiD PF01977.11 EFX01795.1 - 1.1e-117 392.9 0.0 1.9e-92 309.8 0.0 2.0 1 1 1 2 2 2 2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Fungal_trans PF04082.13 EFX01796.1 - 3.1e-51 173.7 0.4 5.2e-51 173.0 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFX01796.1 - 1.5e-06 28.2 13.5 0.00025 21.1 0.8 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX01796.1 - 0.00023 21.2 1.9 0.00023 21.2 1.3 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger Ank_2 PF12796.2 EFX01797.1 - 1.4e-29 102.2 5.5 7.1e-14 51.9 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01797.1 - 9.8e-19 66.1 10.6 0.00011 21.8 0.1 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 EFX01797.1 - 9.4e-14 50.1 3.5 0.033 14.4 0.0 7.1 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 EFX01797.1 - 5.8e-12 45.7 5.5 5.1e-08 33.2 0.1 6.0 6 1 0 6 6 6 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX01797.1 - 1.8e-10 40.6 11.4 0.00058 20.0 0.1 6.6 3 2 4 7 7 7 4 Ankyrin repeats (many copies) SNF5 PF04855.7 EFX01798.1 - 3.2e-83 278.9 0.0 4.5e-83 278.4 0.0 1.2 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GalKase_gal_bdg PF10509.4 EFX01798.1 - 2.5e-14 52.2 0.1 5.5e-14 51.1 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.21 EFX01798.1 - 5.9e-12 45.4 1.3 2.2e-11 43.6 0.7 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFX01798.1 - 1.3e-10 41.3 0.0 4.4e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal DUF3546 PF12066.3 EFX01799.1 - 6.2e-26 90.5 7.1 1.4e-25 89.4 4.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) DUF4187 PF13821.1 EFX01799.1 - 2.1e-21 75.2 0.1 5.7e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.8 EFX01799.1 - 2.1e-09 37.9 2.3 2.6e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 Arsenite-resistance protein 2 TMF_TATA_bd PF12325.3 EFX01802.1 - 0.097 12.4 0.8 0.14 11.8 0.6 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Calpain_inhib PF00748.14 EFX01802.1 - 2.2 8.6 6.2 6.7 7.0 0.6 2.1 1 1 1 2 2 2 0 Calpain inhibitor p450 PF00067.17 EFX01803.1 - 1.5e-63 214.9 0.0 1.4e-53 182.1 0.0 2.2 1 1 1 2 2 2 2 Cytochrome P450 Peptidase_M20 PF01546.23 EFX01806.1 - 2.4e-19 69.5 0.0 4e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX01806.1 - 8.9e-06 25.4 0.0 1.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Ank_2 PF12796.2 EFX01807.1 - 1.2e-26 92.8 0.6 1.5e-15 57.2 0.2 2.2 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX01807.1 - 2.2e-21 74.5 0.3 1.9e-10 39.9 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 EFX01807.1 - 4.4e-21 74.8 2.2 3.5e-11 43.3 0.1 2.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX01807.1 - 1.1e-16 60.3 1.6 1.1e-08 35.0 0.2 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX01807.1 - 6.3e-15 53.8 0.0 1.6e-06 27.8 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat COesterase PF00135.23 EFX01808.1 - 3.3e-102 342.9 0.0 4.4e-102 342.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX01808.1 - 5.1e-07 29.4 1.1 1.8e-06 27.7 0.2 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFX01808.1 - 0.0012 18.0 0.5 0.0021 17.3 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family EKR PF10371.4 EFX01808.1 - 0.034 13.6 0.0 0.092 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Glyco_hydro_18 PF00704.23 EFX01809.1 - 2.5e-09 37.0 0.0 1.1e-07 31.6 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 OPT PF03169.10 EFX01810.1 - 9.7e-159 529.7 53.3 1.1e-158 529.5 37.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein TspO_MBR PF03073.10 EFX01813.1 - 1.2e-34 118.9 3.8 1.5e-34 118.6 2.6 1.1 1 0 0 1 1 1 1 TspO/MBR family TauD PF02668.11 EFX01815.1 - 9.6e-41 140.1 0.0 1.3e-40 139.6 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PGM_PMM_I PF02878.11 EFX01816.1 - 1.8e-19 69.6 0.6 1.3e-08 34.3 0.1 2.9 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EFX01816.1 - 1.2e-13 51.3 0.0 4.9e-13 49.3 0.0 2.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EFX01816.1 - 1.4e-09 37.8 0.1 1.1e-08 34.8 0.2 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.11 EFX01816.1 - 0.005 16.8 0.3 0.014 15.4 0.0 2.0 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III GFRP PF06399.8 EFX01816.1 - 0.11 12.0 0.0 3.4 7.3 0.0 2.9 3 0 0 3 3 3 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) ERCC4 PF02732.10 EFX01817.1 - 2.3e-27 95.4 0.0 3.8e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 EFX01817.1 - 2.8e-05 24.2 0.0 6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HTH_27 PF13463.1 EFX01817.1 - 0.056 13.7 0.0 0.34 11.2 0.0 2.3 2 0 0 2 2 2 0 Winged helix DNA-binding domain DUF4364 PF14277.1 EFX01817.1 - 0.22 11.1 0.0 0.44 10.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Cpn60_TCP1 PF00118.19 EFX01818.1 - 3.8e-136 454.5 12.6 4.8e-136 454.2 8.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tail_X PF05489.7 EFX01818.1 - 0.022 14.2 0.0 0.068 12.6 0.0 1.8 1 0 0 1 1 1 0 Phage Tail Protein X Glyco_tranf_2_3 PF13641.1 EFX01819.1 - 1.2e-35 123.3 0.0 2.4e-35 122.3 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFX01819.1 - 4.4e-18 65.6 0.2 4.4e-18 65.6 0.1 2.6 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.9 EFX01819.1 - 1.6e-11 43.2 11.7 5.5e-09 34.8 2.8 3.5 2 1 2 4 4 4 2 Cellulose synthase Glycos_transf_2 PF00535.21 EFX01819.1 - 5e-11 42.5 0.0 8.8e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EFX01819.1 - 7.1e-11 41.7 0.0 1.3e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.10 EFX01819.1 - 0.0019 16.6 0.3 0.056 11.8 0.1 2.3 2 0 0 2 2 2 1 Chitin synthase PCI PF01399.22 EFX01820.1 - 4.5e-14 52.6 0.0 6e-13 49.0 0.0 2.6 3 0 0 3 3 3 1 PCI domain SNO PF01174.14 EFX01821.1 - 7.6e-59 198.5 0.0 8.9e-59 198.2 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 EFX01821.1 - 1.7e-11 43.9 0.2 1.3e-10 41.1 0.1 2.0 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.19 EFX01821.1 - 1.7e-06 27.5 0.0 2.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.23 EFX01821.1 - 1.8e-05 24.2 0.0 6.9e-05 22.3 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.12 EFX01821.1 - 0.0027 17.4 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DUF4066 PF13278.1 EFX01821.1 - 0.003 16.8 0.2 0.0048 16.1 0.1 1.4 1 0 0 1 1 1 1 Putative amidotransferase PhoD PF09423.5 EFX01822.1 - 1.8e-09 36.7 0.1 9e-07 27.8 0.0 2.3 2 1 0 2 2 2 2 PhoD-like phosphatase DUF3605 PF12239.3 EFX01824.1 - 1.3e-53 181.1 0.0 1.6e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) MFS_1 PF07690.11 EFX01825.1 - 1.4e-56 191.7 37.9 4.3e-51 173.6 13.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX01825.1 - 4.2e-10 38.7 4.6 4.2e-10 38.7 3.2 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.8 EFX01825.1 - 2.1e-05 22.9 4.1 3.4e-05 22.2 2.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFX01825.1 - 0.00027 19.1 14.1 0.0049 15.0 2.8 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector OATP PF03137.15 EFX01825.1 - 0.049 11.6 3.9 2.3 6.1 0.5 2.6 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF3353 PF11833.3 EFX01825.1 - 7.3 5.9 7.0 8 5.8 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) DUF3439 PF11921.3 EFX01826.1 - 0.016 14.9 0.1 0.016 14.9 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) DSS1_SEM1 PF05160.8 EFX01827.1 - 5.4e-24 83.7 15.2 6.8e-24 83.4 10.5 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family SH3_1 PF00018.23 EFX01828.1 - 4.1e-12 45.2 0.0 6.9e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EFX01828.1 - 3.8e-11 42.2 0.0 7.2e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EFX01828.1 - 4.7e-11 42.0 0.2 7.9e-11 41.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain HNH_2 PF13391.1 EFX01829.1 - 8.1e-06 25.5 0.1 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease UPF0016 PF01169.14 EFX01830.1 - 1.8e-39 133.6 22.6 4.3e-22 78.0 4.4 2.9 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 Acetyltransf_3 PF13302.1 EFX01831.1 - 1.5e-14 54.3 0.0 2.6e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX01831.1 - 5.8e-08 32.6 0.1 1.2e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EFX01831.1 - 6.7e-08 32.6 0.0 9.5e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFX01831.1 - 0.0084 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Cupin_1 PF00190.17 EFX01831.1 - 0.084 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Cupin SKG6 PF08693.5 EFX01832.1 - 0.016 14.4 0.2 0.031 13.5 0.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain VPEP PF07589.6 EFX01832.1 - 6 6.9 6.8 7 6.6 3.2 2.2 2 0 0 2 2 2 0 PEP-CTERM motif Acyl-CoA_dh_1 PF00441.19 EFX01833.1 - 7.4e-34 117.0 4.2 1.3e-33 116.2 2.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EFX01833.1 - 8.1e-21 74.7 0.0 1.8e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 EFX01833.1 - 5.3e-16 57.8 0.0 1.2e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFX01833.1 - 4.9e-14 52.7 0.9 8.3e-14 51.9 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MmgE_PrpD PF03972.9 EFX01834.1 - 3e-146 487.1 0.1 3.4e-146 486.9 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Fungal_trans PF04082.13 EFX01835.1 - 3.1e-12 45.9 0.2 1e-11 44.2 0.1 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX01835.1 - 4.9e-05 23.1 11.6 0.00011 22.0 8.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Toxin_5 PF05294.8 EFX01836.1 - 8.1 6.7 10.4 2 8.6 0.5 2.6 3 0 0 3 3 3 0 Scorpion short toxin Choline_transpo PF04515.7 EFX01837.1 - 2.6e-100 335.4 24.3 2.6e-100 335.4 16.9 2.0 1 1 1 2 2 2 1 Plasma-membrane choline transporter RNB PF00773.14 EFX01838.1 - 5.7e-92 308.4 0.0 8.5e-92 307.8 0.0 1.2 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 EFX01838.1 - 1.8e-08 34.5 0.0 6.9e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 PIN domain Dyp_perox PF04261.7 EFX01839.1 - 5.2e-92 307.9 0.0 6.5e-92 307.6 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family DUF3329 PF11808.3 EFX01841.1 - 0.0086 16.1 0.6 0.18 11.8 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3329) MARVEL PF01284.18 EFX01841.1 - 0.035 13.9 9.7 0.059 13.1 6.8 1.4 1 0 0 1 1 1 0 Membrane-associating domain DUF202 PF02656.10 EFX01841.1 - 0.1 12.8 5.4 0.93 9.7 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Ninjurin PF04923.7 EFX01841.1 - 0.11 12.1 2.2 0.24 11.1 0.2 2.1 2 0 0 2 2 2 0 Ninjurin Nefa_Nip30_N PF10187.4 EFX01842.1 - 1.6e-23 82.7 8.3 1.6e-23 82.7 5.7 2.2 2 1 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 YcbB PF08664.5 EFX01842.1 - 0.03 14.1 0.1 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 YcbB domain DUF2075 PF09848.4 EFX01842.1 - 0.042 12.8 0.9 0.07 12.0 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) FUSC PF04632.7 EFX01842.1 - 0.87 7.9 2.1 1.2 7.5 1.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ATP-sulfurylase PF01747.12 EFX01843.1 - 9.3e-88 293.1 0.0 1.4e-87 292.5 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.15 EFX01843.1 - 3e-55 186.1 0.0 4.8e-55 185.5 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.1 EFX01843.1 - 8.5e-51 171.5 0.0 1.3e-50 170.9 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.1 EFX01843.1 - 0.012 15.5 0.6 0.021 14.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.5 EFX01843.1 - 0.055 12.6 0.0 0.084 12.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Glyco_hydro_43 PF04616.9 EFX01844.1 - 1.2e-34 119.7 5.8 1.5e-34 119.3 4.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GN3L_Grn1 PF08701.6 EFX01845.1 - 1.1e-22 79.7 8.7 2.1e-22 78.8 6.0 1.4 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 EFX01845.1 - 1.3e-21 76.7 0.0 7e-13 48.5 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFX01845.1 - 1.2e-08 34.9 0.7 0.005 16.6 0.0 3.5 3 0 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.22 EFX01845.1 - 3.2e-08 33.2 0.0 0.0052 16.2 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 EFX01845.1 - 1.5e-05 24.3 0.0 0.0088 15.3 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 EFX01845.1 - 0.00068 18.8 0.1 0.0013 17.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFX01845.1 - 0.01 15.8 3.1 0.027 14.4 0.1 2.7 3 1 0 3 3 3 0 AAA ATPase domain Miro PF08477.8 EFX01845.1 - 0.016 15.7 0.0 2.7 8.4 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein PGA2 PF07543.7 EFX01845.1 - 0.024 14.4 3.6 0.067 12.9 2.5 1.7 1 0 0 1 1 1 0 Protein trafficking PGA2 AIG1 PF04548.11 EFX01845.1 - 0.052 12.6 0.0 4.2 6.4 0.0 2.3 2 0 0 2 2 2 0 AIG1 family PduV-EutP PF10662.4 EFX01845.1 - 0.06 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 EFX01845.1 - 0.077 12.6 0.1 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Arf PF00025.16 EFX01845.1 - 0.13 11.5 0.0 0.39 9.9 0.0 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family bZIP_1 PF00170.16 EFX01847.1 - 4.9e-09 36.0 12.4 8.5e-09 35.2 8.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor ERM PF00769.14 EFX01847.1 - 0.00078 19.0 8.1 0.001 18.6 5.6 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family PAP1 PF08601.5 EFX01847.1 - 0.0026 17.5 0.0 0.0026 17.5 0.0 2.8 1 1 1 3 3 3 1 Transcription factor PAP1 bZIP_Maf PF03131.12 EFX01847.1 - 0.042 14.1 17.0 0.096 12.9 11.6 1.7 1 1 0 1 1 1 0 bZIP Maf transcription factor bZIP_2 PF07716.10 EFX01847.1 - 0.22 11.3 17.6 0.8 9.5 11.0 2.2 1 1 1 2 2 2 0 Basic region leucine zipper DUF966 PF06136.8 EFX01847.1 - 0.27 10.6 5.8 0.36 10.1 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Herpes_UL25 PF01499.11 EFX01847.1 - 0.29 9.4 6.1 0.4 8.9 4.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family V_ATPase_I PF01496.14 EFX01847.1 - 0.38 8.5 1.0 0.47 8.2 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Glutaredoxin2_C PF04399.8 EFX01847.1 - 0.43 10.1 2.6 0.75 9.3 1.8 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain DUF972 PF06156.8 EFX01847.1 - 0.84 10.0 4.7 0.12 12.7 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF972) PAT1 PF09770.4 EFX01847.1 - 2.5 6.2 19.9 3.3 5.8 13.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ADIP PF11559.3 EFX01847.1 - 2.6 7.9 16.3 4.4 7.1 11.3 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FKBP_C PF00254.23 EFX01848.1 - 2.8e-21 75.3 0.1 2.5e-12 46.6 0.0 2.2 1 1 1 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase zinc_ribbon_2 PF13240.1 EFX01850.1 - 0.88 9.1 5.5 13 5.4 0.9 2.5 2 0 0 2 2 2 0 zinc-ribbon domain COesterase PF00135.23 EFX01851.1 - 3.9e-84 283.2 1.4 1.7e-75 254.7 0.4 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX01851.1 - 1.4e-09 37.8 0.1 2.3e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX01851.1 - 0.0046 16.8 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family OrfB_Zn_ribbon PF07282.6 EFX01854.1 - 0.032 13.9 3.7 0.078 12.6 2.6 1.7 1 1 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.2 EFX01854.1 - 0.086 12.6 1.4 0.16 11.8 0.9 1.4 1 0 0 1 1 1 0 Double zinc ribbon FYDLN_acid PF09538.5 EFX01854.1 - 0.12 12.9 0.5 0.15 12.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF479 PF04336.7 EFX01855.1 - 0.0039 17.2 0.8 0.011 15.7 0.5 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF479 CENP-F_leu_zip PF10473.4 EFX01855.1 - 0.027 14.3 2.4 0.052 13.4 1.6 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Snf7 PF03357.16 EFX01855.1 - 0.035 13.4 2.8 0.049 13.0 1.9 1.3 1 0 0 1 1 1 0 Snf7 DivIC PF04977.10 EFX01855.1 - 0.038 13.4 2.5 1.4 8.4 0.1 2.4 1 1 1 2 2 2 0 Septum formation initiator APG6 PF04111.7 EFX01855.1 - 0.04 12.9 0.0 0.044 12.8 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 OmpH PF03938.9 EFX01855.1 - 0.052 13.4 0.2 0.052 13.4 0.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) V_ATPase_I PF01496.14 EFX01855.1 - 0.11 10.3 0.5 0.13 10.0 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Snapin_Pallidin PF14712.1 EFX01855.1 - 0.11 12.7 2.3 0.37 11.1 1.6 1.9 1 1 0 1 1 1 0 Snapin/Pallidin DUF4140 PF13600.1 EFX01855.1 - 0.48 10.9 12.5 2.1 8.8 0.4 2.9 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) TMF_TATA_bd PF12325.3 EFX01855.1 - 4.9 6.9 9.3 13 5.5 4.3 2.7 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Glyco_trans_2_3 PF13632.1 EFX01856.1 - 4.1e-47 160.3 4.0 4.1e-47 160.3 2.8 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFX01856.1 - 4.8e-07 29.7 0.0 1.5e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EFX01856.1 - 4.9e-06 26.3 0.0 3.2e-05 23.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EFX01856.1 - 0.016 14.5 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 21 DUF3471 PF11954.3 EFX01856.1 - 0.024 14.4 0.0 0.06 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3471) NAC PF01849.13 EFX01857.1 - 1.6e-20 72.3 0.2 3.6e-20 71.2 0.1 1.7 2 0 0 2 2 2 1 NAC domain Abhydrolase_1 PF00561.15 EFX01858.1 - 9.5e-21 74.4 0.5 1.7e-20 73.6 0.3 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.11 EFX01858.1 - 3e-18 64.9 0.4 7.6e-18 63.6 0.0 1.9 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 EFX01858.1 - 1.3e-08 35.0 0.6 2.4e-08 34.1 0.4 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 EFX01858.1 - 0.0016 17.9 0.1 0.36 10.2 0.0 2.5 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Thioredox_DsbH PF03190.10 EFX01859.1 - 1.8e-57 193.6 0.0 3.7e-57 192.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.1 EFX01859.1 - 1.7e-06 27.9 0.0 3.8e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_76 PF03663.9 EFX01859.1 - 0.0066 15.8 0.0 0.055 12.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 76 HTH_10 PF04967.7 EFX01859.1 - 0.051 13.1 0.1 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain HTH_7 PF02796.10 EFX01859.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DUF1680 PF07944.7 EFX01859.1 - 0.15 10.3 0.0 0.28 9.3 0.0 1.4 1 0 0 1 1 1 0 Putative glycosyl hydrolase of unknown function (DUF1680) Rsm22 PF09243.5 EFX01860.1 - 2.4e-32 112.0 0.0 1.7e-19 69.9 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 Thioredoxin PF00085.15 EFX01860.1 - 3.3e-29 100.6 0.0 5.6e-29 99.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFX01860.1 - 6.4e-08 32.7 0.0 1.9e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX01860.1 - 2.1e-06 27.7 0.0 2e-05 24.6 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like Methyltransf_23 PF13489.1 EFX01860.1 - 0.00018 21.2 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Thioredoxin_9 PF14595.1 EFX01860.1 - 0.0053 16.3 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 EFX01860.1 - 0.0064 16.4 0.0 0.018 15.0 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 EFX01860.1 - 0.0067 15.9 0.1 1.8 8.1 0.0 2.3 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.16 EFX01860.1 - 0.0078 15.8 0.1 1.2 8.7 0.0 2.5 1 1 1 2 2 2 1 AhpC/TSA family HyaE PF07449.6 EFX01860.1 - 0.11 12.3 0.0 0.38 10.6 0.0 1.9 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE adh_short PF00106.20 EFX01861.1 - 5.6e-29 101.2 1.6 9.3e-29 100.4 1.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01861.1 - 2.6e-24 86.2 0.0 3.7e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01861.1 - 1.1e-14 54.4 0.5 1.7e-14 53.8 0.4 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFX01861.1 - 0.00037 20.5 1.4 0.00081 19.4 1.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding ADH_zinc_N PF00107.21 EFX01861.1 - 0.055 13.0 3.5 6.1 6.4 2.4 2.3 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Epimerase PF01370.16 EFX01861.1 - 0.099 12.0 0.2 0.37 10.1 0.1 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF1372 PF07116.6 EFX01861.1 - 0.1 12.5 0.0 0.4 10.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1372) SNase PF00565.12 EFX01862.1 - 5.6e-71 235.6 0.2 1.3e-21 76.8 0.0 5.6 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.19 EFX01862.1 - 6.7e-23 80.8 0.0 1.6e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 Tudor domain SMN PF06003.7 EFX01862.1 - 6.9e-05 22.0 0.0 0.00015 20.9 0.0 1.5 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Aa_trans PF01490.13 EFX01864.1 - 1e-89 300.8 19.3 1.4e-89 300.4 13.4 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 EFX01864.1 - 0.00048 19.0 20.5 0.00086 18.2 14.2 1.5 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family SSF PF00474.12 EFX01865.1 - 4.5e-18 65.0 29.5 8e-18 64.2 20.4 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DUF4179 PF13786.1 EFX01865.1 - 0.64 10.2 2.3 21 5.4 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Abhydrolase_1 PF00561.15 EFX01866.1 - 4.1e-15 55.9 0.2 4.7e-13 49.2 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX01866.1 - 1.5e-09 38.1 11.1 3.6e-08 33.5 7.7 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EFX01866.1 - 4.5e-05 22.9 0.0 7.6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase PAP_assoc PF03828.14 EFX01867.1 - 1.5e-18 66.4 0.1 4e-18 65.0 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EFX01867.1 - 8.5e-07 29.2 0.0 1.5e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Metallophos PF00149.23 EFX01868.1 - 1.6e-07 30.8 0.0 1.3e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFX01868.1 - 9.2e-07 28.8 0.0 1.8e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RRM_1 PF00076.17 EFX01871.1 - 1.7e-14 53.1 0.0 2.6e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01871.1 - 4.6e-11 42.5 0.0 7.6e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01871.1 - 1.7e-07 30.9 0.0 3.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3395 PF11875.3 EFX01871.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) Pirin PF02678.11 EFX01872.1 - 4.5e-26 90.8 0.5 2.2e-25 88.5 0.4 2.0 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.6 EFX01872.1 - 0.00017 21.0 1.6 0.0033 16.8 0.6 2.9 2 1 0 2 2 2 1 Cupin domain Grp1_Fun34_YaaH PF01184.14 EFX01874.1 - 1.7e-87 292.1 18.2 2.1e-87 291.8 12.6 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family PHD PF00628.24 EFX01875.1 - 6.9e-10 38.4 1.7 1.5e-09 37.3 1.2 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 EFX01875.1 - 0.015 14.5 3.5 0.029 13.6 2.4 1.4 1 0 0 1 1 1 0 PHD-finger Romo1 PF10247.4 EFX01878.1 - 4.7e-27 93.9 11.0 6.5e-27 93.5 7.6 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.14 EFX01878.1 - 0.62 10.1 6.9 1 9.4 4.7 1.3 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_OmpA PF13436.1 EFX01878.1 - 0.76 9.4 2.9 5.5 6.6 2.0 2.0 1 1 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Spore_YabQ PF09578.5 EFX01878.1 - 0.9 9.5 4.9 1.3 9.0 0.7 2.1 1 1 1 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) Gly-zipper_YMGG PF13441.1 EFX01878.1 - 4.5 6.8 6.7 4.8 6.7 0.7 1.9 1 1 1 2 2 2 0 YMGG-like Gly-zipper Herpes_capsid PF06112.6 EFX01880.1 - 0.067 13.2 1.9 0.14 12.1 1.3 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Glyco_hydro_16 PF00722.16 EFX01881.1 - 2.4e-18 66.0 4.7 3.5e-18 65.5 2.0 1.9 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 TaqI_C PF12950.2 EFX01881.1 - 0.028 14.1 0.0 0.079 12.7 0.0 1.7 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain Memo PF01875.12 EFX01882.1 - 6.6e-69 231.8 0.0 7.8e-69 231.6 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Adaptin_N PF01602.15 EFX01883.1 - 1.4e-110 370.1 0.1 1.8e-110 369.7 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 EFX01883.1 - 7.4e-57 191.4 2.9 1.5e-56 190.3 2.0 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 EFX01883.1 - 4.2e-14 52.5 0.9 1.5e-05 25.1 0.0 5.9 3 1 3 6 6 6 5 HEAT repeats HEAT_PBS PF03130.11 EFX01883.1 - 0.0061 16.9 1.3 5.5 7.7 0.0 4.7 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat DUF3730 PF12530.3 EFX01883.1 - 0.21 11.4 3.1 3.1 7.6 1.0 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3730) HEAT PF02985.17 EFX01883.1 - 0.64 10.2 8.5 3.9 7.8 0.3 4.5 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.1 EFX01883.1 - 0.68 10.5 6.4 0.56 10.7 0.5 3.4 2 1 1 3 3 3 0 HEAT-like repeat FSH1 PF03959.8 EFX01884.1 - 1.9e-56 190.8 0.0 3e-56 190.2 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) ATP-synt_J PF04911.7 EFX01884.1 - 1.7e-20 72.2 0.4 3.5e-20 71.2 0.3 1.5 1 0 0 1 1 1 1 ATP synthase j chain Abhydrolase_6 PF12697.2 EFX01884.1 - 3.8e-09 36.7 0.4 4.8e-08 33.1 0.3 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX01884.1 - 7.2e-07 29.0 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFX01884.1 - 0.0022 17.4 0.0 3.1 7.1 0.0 2.9 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase DLH PF01738.13 EFX01884.1 - 0.0068 15.7 0.0 0.77 9.0 0.0 2.4 2 0 0 2 2 2 1 Dienelactone hydrolase family GST_N_3 PF13417.1 EFX01884.1 - 0.0088 16.2 0.2 0.035 14.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Esterase_phd PF10503.4 EFX01884.1 - 0.016 14.4 0.6 1.9 7.6 0.0 2.3 1 1 1 2 2 2 0 Esterase PHB depolymerase BAAT_C PF08840.6 EFX01884.1 - 0.093 12.4 0.0 0.82 9.3 0.0 2.5 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.15 EFX01884.1 - 0.26 10.6 1.8 3.8 6.8 1.0 2.2 1 1 0 2 2 2 0 Putative esterase MFS_1 PF07690.11 EFX01885.1 - 1.8e-41 142.0 24.7 1.2e-40 139.2 12.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Wbp11 PF09429.5 EFX01885.1 - 4.1e-19 68.3 6.2 1.1e-18 66.9 3.3 2.2 2 0 0 2 2 2 1 WW domain binding protein 11 Sugar_tr PF00083.19 EFX01885.1 - 4e-09 35.5 1.7 4e-09 35.5 1.2 1.8 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.2 EFX01885.1 - 0.11 12.2 2.5 2.9 7.7 0.0 2.8 2 0 0 2 2 2 0 MFS_1 like family zf-met PF12874.2 EFX01886.1 - 8.4e-06 25.8 1.6 0.00041 20.4 0.3 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EFX01886.1 - 1.4e-05 25.1 0.8 0.00055 20.0 0.1 2.0 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 EFX01886.1 - 1.6e-05 24.8 2.3 0.00037 20.5 0.1 2.7 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFX01886.1 - 7.3e-05 22.5 9.5 0.00061 19.6 0.4 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX01886.1 - 7.5e-05 22.8 7.2 0.012 15.8 0.2 2.6 2 1 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX01886.1 - 0.00044 20.3 8.1 0.023 15.0 0.3 2.8 2 1 0 2 2 2 2 C2H2-type zinc finger zf-DBF PF07535.7 EFX01886.1 - 0.031 13.9 0.5 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 DBF zinc finger Zn-ribbon_8 PF09723.5 EFX01886.1 - 0.2 11.6 2.1 4.8 7.2 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.1 EFX01886.1 - 0.5 10.7 6.7 11 6.4 1.6 2.6 2 1 0 2 2 2 0 Zinc-finger double domain CHCH PF06747.8 EFX01888.1 - 4.3e-08 32.8 11.4 4.2e-06 26.5 4.1 2.4 2 0 0 2 2 2 2 CHCH domain Cmc1 PF08583.5 EFX01888.1 - 0.00057 19.6 8.5 0.16 11.7 2.0 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.12 EFX01888.1 - 1 9.3 9.0 2.5 8.2 2.3 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 EFX01888.1 - 1.6 8.8 7.1 12 6.0 3.6 2.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 zf-C3H1 PF10650.4 EFX01889.1 - 0.00015 21.1 0.3 0.00027 20.3 0.2 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain SnoaL_2 PF12680.2 EFX01891.1 - 8.5e-08 32.5 0.0 1e-07 32.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.1 EFX01891.1 - 3.6e-07 30.2 0.1 4.5e-07 29.9 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.1 EFX01891.1 - 2.2e-06 27.6 0.1 3.4e-06 26.9 0.1 1.3 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 EFX01891.1 - 0.00069 19.7 0.0 0.00084 19.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) NTF2 PF02136.15 EFX01891.1 - 0.0042 17.4 0.0 0.0057 17.0 0.0 1.3 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Kunitz_legume PF00197.13 EFX01891.1 - 0.0064 16.0 0.0 0.0071 15.9 0.0 1.1 1 0 0 1 1 1 1 Trypsin and protease inhibitor SnoaL PF07366.7 EFX01891.1 - 0.01 15.3 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase Imm-NTF2 PF15655.1 EFX01891.1 - 0.071 13.5 0.1 0.11 13.0 0.1 1.2 1 0 0 1 1 1 0 NTF2 fold immunity protein ketoacyl-synt PF00109.21 EFX01892.1 - 4.7e-63 213.0 0.9 2.2e-33 115.8 0.2 2.6 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 EFX01892.1 - 9.1e-54 181.8 0.6 6.4e-53 179.1 0.0 2.6 3 0 0 3 3 3 1 KR domain Acyl_transf_1 PF00698.16 EFX01892.1 - 2.1e-51 175.1 0.1 5.6e-51 173.7 0.1 1.6 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.1 EFX01892.1 - 6.8e-45 153.4 0.0 1.3e-44 152.6 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 EFX01892.1 - 1.2e-41 142.4 1.4 1.6e-40 138.7 0.0 3.3 4 0 0 4 4 4 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFX01892.1 - 2e-20 72.8 0.1 1.4e-17 63.6 0.0 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.21 EFX01892.1 - 8.8e-11 41.4 0.2 5.3e-10 38.9 0.0 2.5 3 0 0 3 3 3 1 Zinc-binding dehydrogenase PP-binding PF00550.20 EFX01892.1 - 0.00055 20.1 0.1 0.0017 18.6 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Eno-Rase_NADH_b PF12242.3 EFX01892.1 - 0.0029 17.3 0.5 0.015 15.0 0.0 2.4 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.15 EFX01892.1 - 0.033 14.2 0.2 0.61 10.1 0.0 3.0 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase NUDIX PF00293.23 EFX01893.1 - 7.6e-15 54.7 0.1 1.1e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Abhydrolase_6 PF12697.2 EFX01894.1 - 1.2e-10 41.6 3.6 1.2e-10 41.6 2.5 2.6 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX01894.1 - 3.4e-07 30.0 0.0 6.7e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX01894.1 - 3.4e-05 23.6 0.1 7.4e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EFX01894.1 - 0.0032 17.7 0.5 0.0058 16.8 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_3 PF07859.8 EFX01894.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.8 EFX01894.1 - 0.12 11.9 0.2 0.52 9.8 0.2 1.9 1 1 0 1 1 1 0 PGAP1-like protein Glyco_hydro_3 PF00933.16 EFX01895.1 - 3.3e-89 298.8 0.0 4.7e-89 298.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX01895.1 - 1.5e-49 168.6 0.0 1.4e-48 165.4 0.0 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX01895.1 - 2.2e-19 69.1 0.1 4.2e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain adh_short_C2 PF13561.1 EFX01896.1 - 1.6e-20 73.9 0.2 3.6e-20 72.7 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX01896.1 - 3.5e-15 56.3 7.2 8.5e-15 55.0 5.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX01896.1 - 8.9e-08 31.9 2.6 2.3e-07 30.6 1.8 1.6 1 1 0 1 1 1 1 KR domain DUF3433 PF11915.3 EFX01897.1 - 7.3e-24 83.7 3.2 7.3e-24 83.7 2.2 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) Ribosomal_S5 PF00333.15 EFX01898.1 - 2.2e-28 97.7 2.1 2.2e-28 97.7 1.4 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 EFX01898.1 - 7.1e-21 73.2 0.0 1.3e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Cu-oxidase_2 PF07731.9 EFX01899.1 - 8.8e-39 132.1 4.0 6.1e-38 129.4 0.3 3.2 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.17 EFX01899.1 - 1.1e-34 119.6 0.1 1.5e-32 112.7 0.0 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 EFX01899.1 - 3.4e-29 100.9 1.0 1e-25 89.7 0.8 2.9 3 0 0 3 3 3 2 Multicopper oxidase FMO-like PF00743.14 EFX01899.1 - 3.3e-26 91.5 0.0 1.1e-15 56.8 0.0 2.3 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFX01899.1 - 6.2e-11 42.7 0.0 1.7e-10 41.2 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX01899.1 - 0.0001 21.3 0.0 0.014 14.2 0.0 2.9 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Glyco_hydro_7 PF00840.15 EFX01900.1 - 5.6e-201 667.5 26.8 6.5e-201 667.3 18.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 ABC1 PF03109.11 EFX01901.1 - 1.4e-22 79.8 0.0 3.3e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 ABC1 family DUF914 PF06027.7 EFX01902.1 - 2e-98 329.3 16.0 2.6e-98 328.9 11.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 EFX01902.1 - 2.3e-05 24.4 30.3 9.3e-05 22.4 5.2 2.6 2 1 1 3 3 3 2 EamA-like transporter family EmrE PF13536.1 EFX01902.1 - 0.0033 17.5 5.8 0.0033 17.5 4.1 2.7 3 0 0 3 3 3 1 Multidrug resistance efflux transporter UAA PF08449.6 EFX01902.1 - 0.0096 14.8 13.1 0.016 14.1 9.1 1.3 1 1 0 1 1 1 1 UAA transporter family Ninjurin PF04923.7 EFX01902.1 - 0.05 13.3 0.0 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 Ninjurin TPT PF03151.11 EFX01902.1 - 0.051 13.2 21.8 0.36 10.4 2.8 2.5 2 1 0 2 2 2 0 Triose-phosphate Transporter family DUF2721 PF11026.3 EFX01902.1 - 0.52 9.9 4.4 0.21 11.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) FUSC-like PF12805.2 EFX01902.1 - 3.7 6.3 6.6 0.19 10.6 0.3 1.9 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS Bax1-I PF01027.15 EFX01903.1 - 2.8e-49 167.5 27.0 3.3e-49 167.2 18.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Amidohydro_1 PF01979.15 EFX01904.1 - 5.5e-24 85.4 0.1 1.9e-23 83.6 0.1 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 EFX01904.1 - 2.8e-09 37.4 5.0 4.1e-09 36.8 3.5 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 EFX01904.1 - 1.3e-08 34.5 0.0 3.3e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EFX01904.1 - 5.8e-08 32.3 0.4 0.0034 16.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Gln-synt_C PF00120.19 EFX01905.1 - 1.2e-46 158.9 0.0 1.5e-45 155.4 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Methyltransf_11 PF08241.7 EFX01905.1 - 1.5e-08 35.0 0.0 3.1e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX01905.1 - 1.3e-07 32.2 0.0 2.7e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX01905.1 - 0.00025 21.4 0.0 0.00051 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX01905.1 - 0.00027 20.7 0.0 0.00066 19.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX01905.1 - 0.0017 18.3 1.5 0.0041 17.1 0.6 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX01905.1 - 0.039 14.3 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EFX01905.1 - 0.17 11.2 0.2 0.48 9.7 0.2 1.7 1 1 0 1 1 1 0 Methyltransferase small domain WD40 PF00400.27 EFX01906.1 - 5.6e-32 108.4 6.1 3.6e-07 29.8 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EFX01906.1 - 0.15 11.6 0.0 8.8 5.9 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.17 EFX01907.1 - 1.7e-13 49.9 0.0 5.5e-13 48.3 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX01907.1 - 3.6e-09 36.4 0.0 1.1e-07 31.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX01907.1 - 0.00077 19.2 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP PF00230.15 EFX01908.1 - 1.8e-51 174.7 14.3 2.3e-51 174.4 9.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein MLTD_N PF06474.7 EFX01909.1 - 0.071 13.3 1.1 10 6.3 0.0 2.6 2 0 0 2 2 2 0 MltD lipid attachment motif G-patch PF01585.18 EFX01910.1 - 2.5e-09 36.7 1.3 5.3e-09 35.7 0.9 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EFX01910.1 - 2.1e-05 24.2 0.2 5.2e-05 23.0 0.2 1.6 1 0 0 1 1 1 1 DExH-box splicing factor binding site zf-C2H2_jaz PF12171.3 EFX01910.1 - 0.00023 21.1 0.1 0.26 11.4 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EFX01910.1 - 0.00095 19.2 0.1 0.19 11.8 0.0 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 EFX01910.1 - 0.015 15.4 0.1 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RED_N PF07808.8 EFX01910.1 - 0.047 12.9 0.5 0.096 11.8 0.3 1.5 1 0 0 1 1 1 0 RED-like protein N-terminal region zf-C2H2_4 PF13894.1 EFX01910.1 - 0.23 11.8 5.0 3.5 8.1 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.11 EFX01911.1 - 7.5e-34 116.9 55.6 7.7e-31 107.0 18.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX01911.1 - 5.1e-09 35.2 6.1 5.1e-09 35.2 4.2 2.2 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.8 EFX01911.1 - 0.0015 16.7 3.4 0.0015 16.7 2.4 2.4 3 0 0 3 3 3 2 Transmembrane secretion effector MFS_1_like PF12832.2 EFX01911.1 - 0.034 13.9 1.4 3.5 7.4 0.0 3.1 2 0 0 2 2 2 0 MFS_1 like family MFS_2 PF13347.1 EFX01911.1 - 0.088 11.1 20.0 0.11 10.9 6.2 3.3 1 1 1 2 2 2 0 MFS/sugar transport protein PAPS_reduct PF01507.14 EFX01912.1 - 6.1e-39 133.6 0.0 8.2e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Rpp20 PF12328.3 EFX01913.1 - 4.8e-20 71.6 0.0 2.2e-19 69.5 0.0 1.8 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 EFX01913.1 - 4.4e-13 48.6 0.0 6.6e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Alba CDP-OH_P_transf PF01066.16 EFX01914.1 - 1.5e-17 63.7 1.1 1.5e-17 63.7 0.7 2.7 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Peptidase_C1_2 PF03051.10 EFX01916.1 - 1.9e-52 178.2 0.0 1.4e-47 162.2 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family M20_dimer PF07687.9 EFX01917.1 - 8.8e-06 25.4 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase dimerisation domain Cm_res_leader PF08077.6 EFX01917.1 - 0.33 10.7 3.7 0.39 10.5 0.7 2.2 2 0 0 2 2 2 0 Chloramphenicol resistance gene leader peptide ApoLp-III PF07464.6 EFX01918.1 - 0.13 12.2 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) zf-nanos PF05741.8 EFX01918.1 - 0.36 10.8 2.5 0.51 10.3 0.5 2.2 2 1 0 2 2 2 0 Nanos RNA binding domain Cu-oxidase_3 PF07732.10 EFX01919.1 - 2.6e-46 156.1 6.1 4.4e-44 148.9 0.3 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX01919.1 - 8.6e-34 115.9 9.3 1.1e-32 112.4 1.1 3.7 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 EFX01919.1 - 3.7e-25 88.6 0.0 1.4e-24 86.7 0.0 1.9 2 0 0 2 2 2 1 Multicopper oxidase A2M PF00207.17 EFX01920.1 - 0.026 14.0 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 Alpha-2-macroglobulin family Apt1 PF10351.4 EFX01920.1 - 3.4 6.4 6.8 5.1 5.8 4.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Period_C PF12114.3 EFX01920.1 - 6.7 6.2 19.4 13 5.2 13.5 1.5 1 0 0 1 1 1 0 Period protein 2/3C-terminal region MFS_1 PF07690.11 EFX01921.1 - 5.2e-18 64.8 38.6 1.3e-17 63.5 26.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX01921.1 - 1.1e-06 27.2 12.7 1.3e-06 26.9 8.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pex14_N PF04695.8 EFX01921.1 - 0.16 12.0 0.5 1.4 9.0 0.0 2.3 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0233 PF06781.7 EFX01921.1 - 1.1 8.9 4.3 1.9 8.1 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0233) GDC-P PF02347.11 EFX01922.1 - 2.7e-178 593.0 0.0 2.6e-164 547.0 0.0 2.4 2 0 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.16 EFX01922.1 - 1.6e-05 24.2 0.0 3.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase DUF3399 PF11879.3 EFX01923.1 - 0.013 15.7 0.1 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) MCLC PF05934.6 EFX01924.1 - 8.5 4.5 4.4 17 3.5 3.1 1.4 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Cloacin PF03515.9 EFX01925.1 - 0.015 14.5 0.3 0.019 14.2 0.2 1.1 1 0 0 1 1 1 0 Colicin-like bacteriocin tRNase domain IgG_binding_B PF01378.12 EFX01925.1 - 0.78 9.5 4.6 19 5.1 1.3 2.5 2 0 0 2 2 2 0 B domain Gly-zipper_YMGG PF13441.1 EFX01925.1 - 1.8 8.1 8.4 0.67 9.5 3.7 1.8 2 0 0 2 2 2 0 YMGG-like Gly-zipper ERCC4 PF02732.10 EFX01926.1 - 3.5e-23 81.9 0.0 7.8e-23 80.8 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.1 EFX01926.1 - 0.048 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain FHA PF00498.21 EFX01927.1 - 7.9e-16 57.9 0.1 2.5e-15 56.3 0.1 1.9 1 0 0 1 1 1 1 FHA domain CENP-Q PF13094.1 EFX01927.1 - 0.04 13.9 19.0 0.041 13.8 2.8 3.3 3 1 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Citrate_synt PF00285.16 EFX01928.1 - 4.2e-99 331.6 0.0 5e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase COX16 PF14138.1 EFX01929.1 - 5.6e-32 109.7 0.1 7.7e-32 109.3 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 HAD PF12710.2 EFX01931.1 - 3.1e-20 73.1 0.0 5.5e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFX01931.1 - 2.1e-10 41.3 1.8 1.3e-08 35.5 0.6 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFX01931.1 - 4.2e-09 36.3 0.1 3.3e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX01931.1 - 6.2e-06 26.5 0.0 1.5e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF705 PF05152.7 EFX01931.1 - 0.00028 19.9 0.2 0.00041 19.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) Acid_PPase PF12689.2 EFX01931.1 - 0.039 13.5 0.0 0.15 11.7 0.0 1.9 1 1 0 1 1 1 0 Acid Phosphatase Put_Phosphatase PF06888.7 EFX01931.1 - 0.13 11.4 0.1 8.8 5.4 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase TFIIS_C PF01096.13 EFX01932.1 - 8.9e-19 66.8 2.1 8.9e-19 66.8 1.5 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 EFX01932.1 - 1.3e-06 27.9 0.9 1.3e-06 27.9 0.6 2.4 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Elf1 PF05129.8 EFX01932.1 - 0.0052 16.4 4.9 0.072 12.7 0.1 2.4 2 1 0 2 2 2 2 Transcription elongation factor Elf1 like Zn_ribbon_recom PF13408.1 EFX01932.1 - 0.073 13.3 0.2 0.073 13.3 0.2 2.4 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.2 EFX01932.1 - 0.16 11.8 8.1 1.3 8.9 1.4 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain DUF2387 PF09526.5 EFX01932.1 - 0.35 10.8 7.2 0.48 10.3 1.3 2.3 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) zf-BED PF02892.10 EFX01932.1 - 0.39 10.5 4.4 1.9 8.2 0.4 3.0 3 0 0 3 3 3 0 BED zinc finger C1_4 PF07975.7 EFX01932.1 - 0.43 10.6 5.2 3.4 7.7 0.4 2.5 2 1 0 2 2 2 0 TFIIH C1-like domain zf-H2C2_2 PF13465.1 EFX01932.1 - 2.4 8.5 5.9 17 5.9 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain Pectate_lyase_3 PF12708.2 EFX01933.1 - 2.8e-50 171.5 13.3 2e-33 116.3 0.3 4.4 3 1 1 4 4 4 3 Pectate lyase superfamily protein End_N_terminal PF12218.3 EFX01933.1 - 0.022 14.2 0.1 0.055 12.9 0.1 1.7 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase CBP4 PF07960.6 EFX01934.1 - 3.3e-34 117.2 2.6 4.1e-34 116.9 1.8 1.0 1 0 0 1 1 1 1 CBP4 Succ_CoA_lig PF13607.1 EFX01934.1 - 0.013 15.1 0.3 0.016 14.7 0.2 1.1 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain DUF3546 PF12066.3 EFX01934.1 - 0.016 15.2 0.5 0.024 14.6 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) FAM212 PF15342.1 EFX01934.1 - 0.056 13.0 0.2 0.1 12.2 0.2 1.4 1 0 0 1 1 1 0 FAM212 family YflT PF11181.3 EFX01934.1 - 0.094 12.8 0.1 0.25 11.4 0.0 1.6 1 1 1 2 2 2 0 Heat induced stress protein YflT IFT46_B_C PF12317.3 EFX01934.1 - 0.094 12.0 0.3 0.11 11.7 0.2 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal TraI PF07057.6 EFX01934.1 - 0.13 12.2 0.7 0.17 11.8 0.5 1.2 1 0 0 1 1 1 0 DNA helicase TraI Choline_kinase PF01633.15 EFX01935.1 - 1.2e-57 194.8 0.0 2.6e-57 193.7 0.0 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 EFX01935.1 - 4.5e-20 70.8 0.0 1e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.18 EFX01935.1 - 1e-08 35.2 0.9 2.8e-08 33.7 0.7 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Collagen PF01391.13 EFX01935.1 - 0.0012 18.3 5.7 0.0025 17.3 3.9 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Transaldolase PF00923.14 EFX01936.1 - 5.7e-95 317.7 1.2 6.6e-95 317.5 0.8 1.0 1 0 0 1 1 1 1 Transaldolase adh_short PF00106.20 EFX01937.1 - 2.1e-20 73.3 3.0 8.5e-20 71.3 2.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01937.1 - 1.3e-18 67.6 0.4 6.8e-18 65.3 0.3 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01937.1 - 1.1e-11 44.6 2.5 3.7e-10 39.7 0.3 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.16 EFX01937.1 - 3.7e-05 23.2 0.5 0.00033 20.1 0.4 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFX01937.1 - 0.00097 18.1 0.0 0.0014 17.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.13 EFX01937.1 - 0.002 17.8 0.4 0.0054 16.4 0.2 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 EFX01937.1 - 0.0035 16.5 0.1 0.0055 15.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.1 EFX01937.1 - 0.1 12.9 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1776 PF08643.5 EFX01937.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Med31 PF05669.7 EFX01938.1 - 1.1e-34 118.1 1.8 1.2e-34 118.0 1.3 1.0 1 0 0 1 1 1 1 SOH1 SUR7 PF06687.7 EFX01939.1 - 3.4e-23 82.3 16.9 4.6e-23 81.9 11.7 1.2 1 0 0 1 1 1 1 SUR7/PalI family OATP PF03137.15 EFX01939.1 - 0.052 11.5 0.4 0.077 11.0 0.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2207 PF09972.4 EFX01939.1 - 0.25 9.9 3.2 0.4 9.1 2.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) NfeD PF01957.13 EFX01939.1 - 2.1 8.4 10.7 0.08 13.0 2.3 2.3 2 1 1 3 3 3 0 NfeD-like C-terminal, partner-binding CorA PF01544.13 EFX01941.1 - 4.2e-13 48.9 0.2 7.3e-13 48.2 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein WD40 PF00400.27 EFX01942.1 - 1.1e-07 31.5 0.8 0.015 15.1 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Phosphodiest PF01663.17 EFX01943.1 - 4.2e-84 282.9 0.5 4.2e-84 282.9 0.3 1.9 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFX01943.1 - 0.21 10.7 0.0 0.21 10.7 0.0 2.6 3 0 0 3 3 3 0 Sulfatase RCR PF12273.3 EFX01943.1 - 2.3 8.7 8.0 0.81 10.2 0.8 2.7 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red ABC_tran PF00005.22 EFX01944.1 - 2e-50 170.6 0.1 5e-27 94.8 0.0 3.9 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFX01944.1 - 4.4e-15 56.4 5.4 0.0016 18.4 0.1 4.2 3 1 1 4 4 4 3 AAA domain SMC_N PF02463.14 EFX01944.1 - 1.9e-12 46.9 0.6 0.0014 17.9 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFX01944.1 - 3.7e-08 33.9 0.2 0.0015 18.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.18 EFX01944.1 - 4e-08 33.2 0.0 0.0074 16.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.1 EFX01944.1 - 5.6e-08 32.1 1.0 0.0064 15.9 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EFX01944.1 - 1.7e-07 30.5 0.1 0.00082 18.5 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_15 PF13175.1 EFX01944.1 - 5.3e-07 29.0 0.0 0.38 9.7 0.0 3.6 3 1 0 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 EFX01944.1 - 2.8e-06 28.1 0.0 0.016 15.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 EFX01944.1 - 4e-06 27.3 0.0 0.013 15.9 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein AAA_10 PF12846.2 EFX01944.1 - 7.9e-06 25.5 0.6 0.36 10.2 0.1 3.8 4 0 0 4 4 4 2 AAA-like domain SbcCD_C PF13558.1 EFX01944.1 - 1.2e-05 25.0 0.0 0.31 10.9 0.0 3.2 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Chromo PF00385.19 EFX01944.1 - 2.8e-05 23.6 2.5 3e-05 23.5 0.8 1.8 2 0 0 2 2 1 1 Chromo (CHRromatin Organisation MOdifier) domain Dynamin_N PF00350.18 EFX01944.1 - 5.2e-05 23.1 0.0 0.17 11.6 0.0 3.5 3 0 0 3 3 3 1 Dynamin family AAA_25 PF13481.1 EFX01944.1 - 0.00038 19.9 0.0 0.17 11.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EFX01944.1 - 0.00064 19.4 0.1 0.65 9.6 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 EFX01944.1 - 0.00081 19.5 3.4 0.87 9.7 0.0 4.1 4 1 0 4 4 3 1 AAA domain MobB PF03205.9 EFX01944.1 - 0.00095 18.8 0.5 0.42 10.3 0.1 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 EFX01944.1 - 0.0013 18.6 0.0 0.041 13.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 EFX01944.1 - 0.0015 18.0 0.0 0.75 9.2 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 EFX01944.1 - 0.0019 17.0 0.8 0.42 9.3 0.0 2.5 2 0 0 2 2 2 1 ArgK protein AAA_33 PF13671.1 EFX01944.1 - 0.0022 17.8 0.0 1.1 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX01944.1 - 0.0036 17.5 0.3 0.23 11.7 0.0 3.1 3 0 0 3 3 2 1 AAA domain DUF87 PF01935.12 EFX01944.1 - 0.0057 16.5 2.7 0.37 10.5 0.0 2.9 3 0 0 3 3 2 1 Domain of unknown function DUF87 RNA_helicase PF00910.17 EFX01944.1 - 0.0057 16.8 0.1 4.5 7.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA PF00004.24 EFX01944.1 - 0.0072 16.5 0.0 4.3 7.5 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.1 EFX01944.1 - 0.012 14.1 0.0 3.3 6.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EFX01944.1 - 0.014 15.2 0.0 2.8 7.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF3093 PF11292.3 EFX01944.1 - 0.014 15.1 0.8 0.12 12.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) DUF815 PF05673.8 EFX01944.1 - 0.027 13.3 0.0 3.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_30 PF13604.1 EFX01944.1 - 0.038 13.5 4.3 5.7 6.4 0.0 3.7 5 0 0 5 5 2 0 AAA domain Septin PF00735.13 EFX01944.1 - 0.063 12.2 0.5 8.7 5.2 0.0 2.8 3 0 0 3 3 3 0 Septin AIG1 PF04548.11 EFX01944.1 - 0.12 11.4 0.6 2.4 7.2 0.0 2.9 3 0 0 3 3 3 0 AIG1 family AAA_16 PF13191.1 EFX01944.1 - 0.16 11.9 7.3 1.7 8.5 0.1 4.3 4 1 0 4 4 3 0 AAA ATPase domain Zeta_toxin PF06414.7 EFX01944.1 - 0.42 9.6 3.4 4.2 6.4 0.0 2.7 3 0 0 3 3 3 0 Zeta toxin AAA_24 PF13479.1 EFX01944.1 - 0.85 9.1 5.2 1.5 8.3 0.1 2.9 3 0 0 3 3 3 0 AAA domain TRAM_LAG1_CLN8 PF03798.11 EFX01945.1 - 3.2e-44 150.8 18.0 5.5e-44 150.0 12.5 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 EFX01945.1 - 3.4e-16 58.5 0.0 1.1e-15 56.8 0.0 2.0 1 0 0 1 1 1 1 TRAM1-like protein TRAP_alpha PF03896.11 EFX01945.1 - 0.15 11.0 0.9 0.24 10.3 0.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nucleoplasmin PF03066.10 EFX01945.1 - 4 6.9 7.4 8 5.9 5.1 1.4 1 0 0 1 1 1 0 Nucleoplasmin SH3_1 PF00018.23 EFX01946.1 - 1.5e-09 37.0 0.6 2.5e-09 36.3 0.0 1.6 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 EFX01946.1 - 3.5e-07 29.5 0.0 7.1e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EFX01946.1 - 4.5e-07 29.3 0.0 9e-07 28.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain ABC2_membrane_5 PF13346.1 EFX01946.1 - 1.3 8.2 18.2 1.9 7.7 12.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1516 PF07457.6 EFX01946.1 - 2.7 8.1 6.2 4 7.5 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) Sod_Cu PF00080.15 EFX01947.1 - 3.7e-43 147.0 4.1 4.3e-43 146.8 2.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) FAD_binding_2 PF00890.19 EFX01948.1 - 2.9e-48 164.7 0.9 3.7e-48 164.3 0.6 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX01948.1 - 2.9e-09 36.2 3.2 3e-08 32.9 2.2 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX01948.1 - 1.1e-07 31.7 0.7 3.9e-07 30.0 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFX01948.1 - 3.2e-06 27.3 0.1 6.9e-06 26.2 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFX01948.1 - 2.5e-05 23.5 0.2 3.8e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 EFX01948.1 - 0.0002 20.5 1.9 0.00065 18.8 0.4 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 EFX01948.1 - 0.00031 20.6 0.0 0.049 13.4 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX01948.1 - 0.0012 17.3 5.0 0.0059 15.1 0.5 2.4 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.17 EFX01948.1 - 0.0098 14.7 4.2 0.013 14.3 1.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.22 EFX01948.1 - 0.026 14.9 0.0 0.41 11.0 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFX01948.1 - 0.034 13.1 0.3 0.058 12.4 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.16 EFX01948.1 - 0.17 11.4 0.5 0.31 10.5 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.20 EFX01949.1 - 5.6e-28 97.9 3.0 8.1e-28 97.4 2.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX01949.1 - 9.5e-16 58.2 0.1 1.2e-15 57.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX01949.1 - 1.1e-10 41.5 1.6 1.8e-10 40.7 1.1 1.3 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EFX01949.1 - 0.00024 20.8 0.3 0.00049 19.7 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 EFX01949.1 - 0.0013 18.2 0.1 0.0022 17.4 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_12 PF08242.7 EFX01949.1 - 0.035 14.5 0.0 0.069 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain THF_DHG_CYH_C PF02882.14 EFX01949.1 - 0.061 12.4 1.2 0.14 11.1 0.1 2.1 3 1 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 EFX01949.1 - 0.068 12.9 1.5 0.49 10.2 0.4 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ChuX_HutX PF06228.8 EFX01949.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Haem utilisation ChuX/HutX NAD_binding_10 PF13460.1 EFX01949.1 - 0.19 11.7 2.6 0.34 10.8 0.5 2.1 1 1 0 2 2 2 0 NADH(P)-binding ICL PF00463.16 EFX01950.1 - 4.7e-193 642.1 0.0 5.5e-193 641.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family Arg_repressor_C PF02863.13 EFX01950.1 - 0.14 11.6 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Fungal_trans PF04082.13 EFX01951.1 - 6.3e-17 61.2 0.3 1.4e-16 60.1 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain NB-ARC PF00931.17 EFX01952.1 - 6.4e-10 38.3 0.0 1.1e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.1 EFX01952.1 - 2.7e-09 36.8 1.7 1.8e-06 27.8 0.0 3.4 2 1 0 2 2 2 2 Tetratricopeptide repeat AAA_22 PF13401.1 EFX01952.1 - 9.7e-07 28.9 0.0 3.2e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain TPR_2 PF07719.12 EFX01952.1 - 0.0048 16.7 2.1 2.6 8.1 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-C2H2_jaz PF12171.3 EFX01952.1 - 0.042 14.0 0.3 0.042 14.0 0.2 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 EFX01952.1 - 0.21 12.0 5.6 0.95 9.9 0.1 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX01952.1 - 3.7 8.0 7.4 2.2 8.8 0.1 4.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type RPEL PF02755.10 EFX01953.1 - 6.4e-12 44.4 3.5 1.7e-09 36.6 0.0 2.6 2 0 0 2 2 2 2 RPEL repeat ChAPs PF09295.5 EFX01953.1 - 0.11 11.2 0.3 0.16 10.6 0.2 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Rad21_Rec8_N PF04825.8 EFX01954.1 - 5.1e-22 77.9 0.0 8.6e-22 77.1 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 EFX01954.1 - 0.038 13.5 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 ScpA/B protein MMR_HSR1 PF01926.18 EFX01956.1 - 3.2e-12 46.4 0.0 6.5e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX01956.1 - 0.0011 18.2 0.0 0.0022 17.2 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_33 PF13671.1 EFX01956.1 - 0.0029 17.5 2.3 1.1 9.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain Lipase_GDSL_2 PF13472.1 EFX01956.1 - 0.0045 17.1 0.1 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family AAA_28 PF13521.1 EFX01956.1 - 0.0063 16.4 0.3 0.5 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 EFX01956.1 - 0.0067 16.2 0.1 0.52 10.0 0.0 2.5 1 1 0 2 2 2 1 Dynamin family DUF258 PF03193.11 EFX01956.1 - 0.019 14.1 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Arf PF00025.16 EFX01956.1 - 0.022 14.0 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFX01956.1 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 EFX01956.1 - 0.033 14.9 0.1 0.14 12.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain GBP PF02263.14 EFX01956.1 - 0.26 10.3 0.0 0.42 9.6 0.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain FrhB_FdhB_N PF04422.8 EFX01957.1 - 0.04 13.7 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term eIF-5a PF01287.15 EFX01958.1 - 1.9e-06 27.7 0.0 3.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold p450 PF00067.17 EFX01959.1 - 1e-55 189.1 0.0 1.2e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Carboxyl_trans PF01039.17 EFX01960.1 - 1.3e-137 459.1 0.0 1.7e-137 458.7 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain RTA1 PF04479.8 EFX01962.1 - 8.1e-42 143.2 7.8 8.1e-42 143.2 5.4 1.4 2 0 0 2 2 2 1 RTA1 like protein DUF202 PF02656.10 EFX01962.1 - 7.1 6.9 7.8 5.2 7.3 0.3 3.1 2 2 2 4 4 4 0 Domain of unknown function (DUF202) SNARE PF05739.14 EFX01963.1 - 2.8e-12 46.1 8.5 2.8e-12 46.1 5.9 3.0 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 EFX01963.1 - 8.9e-07 29.0 6.0 8.9e-07 29.0 4.2 2.6 2 1 0 2 2 2 1 Syntaxin MitMem_reg PF13012.1 EFX01963.1 - 0.0084 16.1 2.4 0.0084 16.1 1.7 2.3 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Cyclase_polyket PF04673.7 EFX01963.1 - 0.061 13.3 0.3 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Polyketide synthesis cyclase DUF2096 PF09869.4 EFX01963.1 - 0.071 12.9 3.4 9 6.1 0.3 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) SPATIAL PF15256.1 EFX01963.1 - 0.76 9.8 6.0 0.74 9.8 1.4 2.1 2 0 0 2 2 2 0 SPATIAL CR6_interact PF10147.4 EFX01963.1 - 1.8 7.8 15.1 0.37 10.0 1.8 2.2 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF2203 PF09969.4 EFX01963.1 - 7.7 6.7 14.5 5.9 7.1 1.9 3.2 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Rogdi_lz PF10259.4 EFX01965.1 - 5.2e-67 225.8 0.0 6e-67 225.6 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Pox_A_type_inc PF04508.7 EFX01965.1 - 0.97 9.3 5.6 0.11 12.3 0.6 1.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat SEN1_N PF12726.2 EFX01966.1 - 2.4e-146 488.7 0.0 2.9e-146 488.5 0.0 1.1 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.1 EFX01966.1 - 7.6e-68 228.5 0.1 7.6e-68 228.5 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 EFX01966.1 - 2.9e-45 154.1 0.0 1.2e-43 148.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX01966.1 - 9.7e-11 41.2 2.4 5e-10 39.0 1.7 2.3 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EFX01966.1 - 2.4e-06 27.2 6.6 9.2e-05 22.1 0.4 3.0 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.13 EFX01966.1 - 3.1e-06 26.8 0.4 0.052 13.0 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 EFX01966.1 - 6.9e-05 22.2 1.6 0.012 14.8 0.0 3.0 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_25 PF13481.1 EFX01966.1 - 0.013 14.8 1.5 0.033 13.5 0.3 2.2 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 EFX01966.1 - 0.014 14.9 0.6 0.48 9.9 0.1 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase zf-PHD-like PF15446.1 EFX01966.1 - 0.017 14.4 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain AAA_22 PF13401.1 EFX01966.1 - 0.082 13.0 0.7 2 8.5 0.1 3.1 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.1 EFX01966.1 - 0.087 13.1 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 EFX01966.1 - 0.13 12.4 1.2 0.32 11.2 0.2 2.2 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DegQ PF08181.6 EFX01966.1 - 0.23 11.1 0.0 0.54 10.0 0.0 1.6 1 0 0 1 1 1 0 DegQ (SacQ) family PI-PLC-X PF00388.14 EFX01967.1 - 2.6e-52 176.1 0.0 7.8e-52 174.5 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EFX01967.1 - 1.7e-33 115.0 0.0 2.8e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.6 EFX01967.1 - 0.23 11.5 0.1 0.48 10.4 0.1 1.4 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like Acyl-CoA_dh_1 PF00441.19 EFX01968.1 - 5.2e-41 140.2 1.5 1.9e-40 138.4 1.0 2.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ADH_N PF08240.7 EFX01968.1 - 2.1e-28 98.2 7.4 2.1e-28 98.2 5.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Acyl-CoA_dh_N PF02771.11 EFX01968.1 - 9.7e-28 97.0 0.4 2.5e-27 95.7 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain ADH_zinc_N PF00107.21 EFX01968.1 - 4.2e-21 74.8 0.3 1.2e-20 73.4 0.2 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Acyl-CoA_dh_2 PF08028.6 EFX01968.1 - 6.8e-16 58.7 0.3 6.8e-16 58.7 0.2 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFX01968.1 - 2.1e-15 55.9 0.2 5.5e-15 54.6 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain AlaDh_PNT_C PF01262.16 EFX01968.1 - 0.01 15.3 0.3 0.03 13.9 0.2 1.7 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HpaB_N PF11794.3 EFX01968.1 - 0.045 13.1 0.1 0.14 11.4 0.0 1.8 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Asp PF00026.18 EFX01969.1 - 2.9e-73 246.8 9.1 3.5e-73 246.6 6.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX01969.1 - 2.2e-06 27.7 0.1 1.7e-05 24.8 0.0 2.4 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFX01969.1 - 0.00045 20.6 1.9 0.039 14.4 0.3 3.1 2 1 0 2 2 2 1 Aspartyl protease Ctr PF04145.10 EFX01970.1 - 5.6e-40 136.7 3.7 1e-39 135.8 2.6 1.5 1 0 0 1 1 1 1 Ctr copper transporter family Abhydrolase_6 PF12697.2 EFX01970.1 - 1.9e-18 67.1 0.1 1.8e-17 64.0 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX01970.1 - 1.3e-08 34.7 0.1 2.7e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX01970.1 - 4.9e-08 32.8 0.2 1.5e-07 31.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFX01970.1 - 0.0091 15.8 0.0 0.033 14.0 0.0 1.9 1 0 0 1 1 1 1 Putative lysophospholipase Cohesin PF00963.13 EFX01970.1 - 0.013 15.3 0.7 0.024 14.4 0.5 1.4 1 0 0 1 1 1 0 Cohesin domain Septin PF00735.13 EFX01971.1 - 1.5e-106 355.5 0.0 3.1e-106 354.5 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EFX01971.1 - 0.00013 21.8 0.0 0.00025 20.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFX01971.1 - 0.0056 15.8 0.3 0.018 14.2 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX01971.1 - 0.018 15.2 0.3 0.051 13.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 EFX01971.1 - 0.022 15.5 4.2 0.069 13.9 0.1 2.8 2 2 0 2 2 2 0 AAA domain GTP_EFTU PF00009.22 EFX01971.1 - 0.055 12.9 0.0 0.18 11.2 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain IIGP PF05049.8 EFX01971.1 - 0.056 12.2 0.0 0.1 11.3 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.18 EFX01971.1 - 0.069 12.9 5.7 1 9.1 0.0 2.9 2 1 1 3 3 3 0 Dynamin family Miro PF08477.8 EFX01971.1 - 0.076 13.5 0.0 0.23 11.9 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein FtsK_SpoIIIE PF01580.13 EFX01971.1 - 0.1 12.0 0.1 0.1 12.0 0.1 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family GLE1 PF07817.8 EFX01971.1 - 0.22 10.4 0.6 0.34 9.7 0.4 1.2 1 0 0 1 1 1 0 GLE1-like protein DUF3653 PF12375.3 EFX01971.1 - 0.25 11.5 2.0 5 7.4 0.6 2.5 2 0 0 2 2 2 0 Phage protein PCI PF01399.22 EFX01972.1 - 3.4e-22 78.7 0.0 1.1e-21 77.1 0.0 1.9 1 0 0 1 1 1 1 PCI domain Asp_Glu_race_2 PF14669.1 EFX01972.1 - 0.00078 18.8 3.4 0.066 12.5 0.3 2.3 1 1 1 2 2 2 2 Putative aspartate racemase Atrophin-1 PF03154.10 EFX01972.1 - 2.1 6.3 5.1 2.8 5.9 3.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Prefoldin_2 PF01920.15 EFX01972.1 - 2.2 8.0 14.5 0.79 9.5 4.9 3.0 3 0 0 3 3 3 0 Prefoldin subunit PI3_PI4_kinase PF00454.22 EFX01973.1 - 3e-45 154.5 0.0 5.2e-45 153.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 EFX01973.1 - 1.4e-22 80.1 0.1 2.6e-22 79.2 0.1 1.5 1 0 0 1 1 1 1 FAT domain FATC PF02260.15 EFX01973.1 - 1.2e-13 50.2 0.4 1.2e-13 50.2 0.3 1.9 2 0 0 2 2 2 1 FATC domain UME PF08064.8 EFX01973.1 - 5.1e-13 48.8 0.0 3.4e-12 46.2 0.0 2.5 2 0 0 2 2 2 1 UME (NUC010) domain HATPase_c PF02518.21 EFX01974.1 - 1.6e-21 76.0 0.1 3.4e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EFX01974.1 - 1.4e-19 70.1 0.0 3.6e-19 68.8 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.1 EFX01974.1 - 1.6e-15 57.3 0.1 5.1e-08 33.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.1 EFX01974.1 - 1.9e-08 33.8 0.1 0.00095 18.9 0.0 2.6 2 0 0 2 2 2 2 PAS domain HisKA PF00512.20 EFX01974.1 - 2.2e-08 33.9 0.1 5.1e-08 32.7 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.5 EFX01974.1 - 7e-05 22.8 0.1 0.16 11.9 0.0 3.7 3 1 0 3 3 3 2 PAS fold PAS_3 PF08447.6 EFX01974.1 - 0.0015 18.5 0.0 5 7.3 0.0 3.3 2 1 0 2 2 2 2 PAS fold PAS PF00989.19 EFX01974.1 - 0.012 15.3 0.0 3.5 7.4 0.0 3.3 2 1 0 2 2 2 0 PAS fold LigB PF02900.13 EFX01977.1 - 7.5e-43 146.4 0.4 7e-42 143.2 0.3 1.9 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DUF2017 PF09438.5 EFX01977.1 - 0.081 12.4 0.1 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) zf-C2H2_4 PF13894.1 EFX01978.1 - 0.00048 20.2 0.1 0.00048 20.2 0.1 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger Mitofilin PF09731.4 EFX01978.1 - 0.0024 16.6 6.4 0.0027 16.4 4.5 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein zf-C2H2_6 PF13912.1 EFX01978.1 - 0.048 13.5 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger DUF3665 PF12427.3 EFX01979.1 - 0.073 12.4 0.1 0.22 10.9 0.1 1.8 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase DASH_Spc19 PF08287.6 EFX01980.1 - 6.9e-41 139.4 1.4 6.9e-41 139.4 1.0 1.5 1 1 1 2 2 2 1 Spc19 Bcr-Abl_Oligo PF09036.5 EFX01980.1 - 0.047 13.6 0.7 0.24 11.3 0.3 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain SlyX PF04102.7 EFX01980.1 - 0.052 13.9 6.9 0.51 10.7 0.3 3.4 3 1 0 3 3 3 0 SlyX DUF2570 PF10828.3 EFX01980.1 - 0.066 12.8 2.9 0.089 12.4 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) TMF_DNA_bd PF12329.3 EFX01980.1 - 0.098 12.4 2.5 17 5.3 1.1 3.3 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding DASH_Spc34 PF08657.5 EFX01980.1 - 0.17 11.5 6.7 2.1 7.9 2.2 2.3 1 1 1 2 2 2 0 DASH complex subunit Spc34 APG6 PF04111.7 EFX01980.1 - 2.2 7.2 5.8 2.9 6.8 4.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 PTCB-BRCT PF12738.2 EFX01981.1 - 1.5e-07 31.1 0.0 2.9e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EFX01981.1 - 3.8e-05 23.7 0.0 7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain fn3 PF00041.16 EFX01981.1 - 0.003 17.6 0.0 0.0072 16.4 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain TFIIA PF03153.8 EFX01981.1 - 0.026 14.4 14.8 0.043 13.7 10.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BTV_NS2 PF04514.7 EFX01981.1 - 0.11 11.3 2.2 0.14 10.9 1.5 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Cwf_Cwc_15 PF04889.7 EFX01981.1 - 0.2 11.3 9.7 0.3 10.7 6.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.1 EFX01981.1 - 0.33 11.2 10.8 0.72 10.1 7.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC27 PF09507.5 EFX01981.1 - 0.38 9.9 27.6 0.52 9.4 19.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RXT2_N PF08595.6 EFX01981.1 - 1.8 8.3 6.6 2.8 7.7 4.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.7 EFX01981.1 - 2.2 6.0 14.9 3.2 5.5 10.3 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.1 EFX01981.1 - 2.9 7.5 6.4 6.3 6.4 4.4 1.5 1 0 0 1 1 1 0 FAM176 family Nucleoplasmin PF03066.10 EFX01981.1 - 4.6 6.7 14.3 10 5.6 9.4 1.8 2 0 0 2 2 2 0 Nucleoplasmin Nucleo_P87 PF07267.6 EFX01981.1 - 5.9 5.4 13.8 8 5.0 9.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PPP4R2 PF09184.6 EFX01981.1 - 9.6 5.6 17.8 16 4.9 12.3 1.2 1 0 0 1 1 1 0 PPP4R2 DUF1275 PF06912.6 EFX01982.1 - 4.6e-37 127.2 15.3 6.1e-37 126.8 10.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Prenyltrans PF00432.16 EFX01982.1 - 0.0094 15.5 0.8 0.17 11.5 0.0 2.6 2 0 0 2 2 2 1 Prenyltransferase and squalene oxidase repeat DUF3040 PF11239.3 EFX01982.1 - 0.12 12.4 0.8 11 6.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Mid2 PF04478.7 EFX01983.1 - 8.7e-08 31.7 6.7 8.7e-08 31.7 4.7 2.5 1 1 0 2 2 2 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 EFX01983.1 - 0.024 13.9 0.4 0.024 13.9 0.3 2.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain CD34_antigen PF06365.7 EFX01983.1 - 0.039 13.6 0.1 0.23 11.1 0.0 1.7 1 1 0 2 2 2 0 CD34/Podocalyxin family FAM196 PF15265.1 EFX01983.1 - 1.1 8.4 25.3 1.5 7.9 17.5 1.1 1 0 0 1 1 1 0 FAM196 family IMS PF00817.15 EFX01985.1 - 3.3e-41 140.5 0.0 7.1e-41 139.4 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EFX01985.1 - 4.1e-16 59.0 1.0 1e-15 57.7 0.1 2.1 3 0 0 3 3 3 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 EFX01985.1 - 0.1 12.6 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif Peptidase_M61 PF05299.7 EFX01986.1 - 0.021 14.8 0.4 0.21 11.5 0.0 2.7 2 0 0 2 2 2 0 M61 glycyl aminopeptidase DUF3684 PF12449.3 EFX01986.1 - 6.6 4.1 13.3 1.8 6.0 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3684) DFP PF04127.10 EFX01987.1 - 1.1e-13 51.2 0.0 0.00032 20.3 0.0 3.1 2 1 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein WH1 PF00568.18 EFX01988.1 - 2e-28 98.3 0.2 2e-28 98.3 0.1 1.4 2 0 0 2 2 2 1 WH1 domain CAP_N PF01213.14 EFX01988.1 - 0.00083 18.7 4.8 0.00083 18.7 3.4 11.2 1 1 10 11 11 11 1 Adenylate cyclase associated (CAP) N terminal NIPSNAP PF07978.8 EFX01989.1 - 2.2e-38 130.3 0.2 5.2e-29 100.2 0.1 2.3 2 0 0 2 2 2 2 NIPSNAP CNH PF00780.17 EFX01990.1 - 2.4e-62 210.8 0.0 3.5e-62 210.3 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.15 EFX01990.1 - 5.1e-30 104.6 1.9 1.5e-29 103.1 0.3 2.1 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.1 EFX01990.1 - 1.6e-12 47.5 0.0 1.5e-11 44.3 0.0 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EFX01990.1 - 0.00088 19.4 0.0 0.0034 17.5 0.0 2.1 1 0 0 1 1 1 1 PH domain ALO PF04030.9 EFX01991.1 - 1.2e-83 280.6 0.0 2.4e-79 266.6 0.0 2.1 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 EFX01991.1 - 3.6e-27 94.5 0.8 9.5e-27 93.1 0.5 1.7 1 1 0 1 1 1 1 FAD binding domain DUF3441 PF11923.3 EFX01993.1 - 1.7e-31 108.1 0.8 7.5e-31 106.0 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3441) FbpA PF05833.6 EFX01993.1 - 2.4e-22 79.1 0.0 2.4e-22 79.1 0.0 2.9 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 EFX01993.1 - 1.4e-12 47.2 2.5 2.5e-12 46.4 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF814) CheX PF13690.1 EFX01993.1 - 0.13 12.1 0.9 0.24 11.2 0.0 1.9 2 0 0 2 2 2 0 Chemotaxis phosphatase CheX DLIC PF05783.6 EFX01994.1 - 9.5e-31 106.9 0.0 1.1e-27 96.9 0.0 2.4 2 1 0 2 2 2 2 Dynein light intermediate chain (DLIC) Methyltrn_RNA_3 PF02598.12 EFX01995.1 - 4.6e-75 252.6 0.0 5.3e-75 252.4 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase Ribosomal_S16 PF00886.14 EFX01996.1 - 4.4e-21 74.3 0.1 9.3e-21 73.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S16 DUF4191 PF13829.1 EFX01996.1 - 0.06 12.4 0.0 0.079 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Pet191_N PF10203.4 EFX01997.1 - 9.2e-27 92.8 3.8 1.2e-26 92.5 2.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 IncA PF04156.9 EFX01998.1 - 3.4e-07 30.0 135.4 0.00025 20.6 3.7 7.6 1 1 6 7 7 7 5 IncA protein ATG16 PF08614.6 EFX01998.1 - 0.0029 17.4 16.0 0.0029 17.4 11.1 8.6 1 1 8 9 9 9 4 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.4 EFX01998.1 - 0.0036 17.1 27.0 0.0036 17.1 18.7 7.5 1 1 6 8 8 8 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 EFX01998.1 - 0.0054 15.9 62.2 0.041 13.0 1.9 6.4 1 1 3 6 6 6 4 Reovirus sigma C capsid protein DUF641 PF04859.7 EFX01998.1 - 0.0077 15.9 2.9 0.0077 15.9 2.0 7.2 1 1 5 7 7 7 1 Plant protein of unknown function (DUF641) Spc7 PF08317.6 EFX01998.1 - 0.31 9.6 106.3 0.1 11.2 13.3 5.6 1 1 4 6 6 6 0 Spc7 kinetochore protein Filament PF00038.16 EFX01998.1 - 1.9 7.8 107.4 0.0087 15.5 19.6 4.3 1 1 1 2 2 2 0 Intermediate filament protein DUF972 PF06156.8 EFX01998.1 - 3.1 8.1 99.2 0.045 14.0 0.9 10.4 1 1 10 11 11 11 0 Protein of unknown function (DUF972) YIF1 PF03878.10 EFX01999.1 - 5.1e-75 251.7 1.4 6.7e-75 251.3 1.0 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 EFX01999.1 - 0.0082 15.6 4.4 0.017 14.5 3.1 1.5 1 0 0 1 1 1 1 Yip1 domain PRCC PF10253.4 EFX01999.1 - 0.064 13.9 0.7 0.096 13.3 0.5 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting CFEM PF05730.6 EFX02001.1 - 2.8e-06 27.0 2.4 2.8e-06 27.0 1.7 3.7 3 0 0 3 3 3 1 CFEM domain YjeF_N PF03853.10 EFX02002.1 - 1.9e-24 86.1 0.0 4.9e-24 84.8 0.0 1.5 1 1 1 2 2 2 1 YjeF-related protein N-terminus HMGL-like PF00682.14 EFX02003.1 - 7.1e-68 228.7 0.1 1e-67 228.3 0.1 1.2 1 0 0 1 1 1 1 HMGL-like SRP-alpha_N PF04086.8 EFX02004.1 - 2.6e-61 207.4 0.0 4.3e-61 206.7 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.17 EFX02004.1 - 2.5e-51 173.9 1.0 4.2e-51 173.1 0.0 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 EFX02004.1 - 4.8e-07 29.7 0.3 1.6e-06 28.1 0.1 1.9 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain ArgK PF03308.11 EFX02004.1 - 3.2e-06 26.1 0.0 6.8e-06 25.0 0.0 1.5 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.18 EFX02004.1 - 0.00034 20.0 0.0 0.00078 18.8 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 EFX02004.1 - 0.0092 15.6 0.1 0.027 14.1 0.0 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EFX02004.1 - 0.018 14.9 0.2 0.05 13.5 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.18 EFX02004.1 - 0.056 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 EFX02004.1 - 0.063 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Glyco_hydro_3_C PF01915.17 EFX02004.1 - 0.063 12.7 5.2 0.048 13.1 1.3 2.3 2 1 0 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain AAA_22 PF13401.1 EFX02004.1 - 0.08 13.0 0.1 1.1 9.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain SUR7 PF06687.7 EFX02005.1 - 3.4e-35 121.5 10.3 5.7e-35 120.8 7.2 1.4 1 0 0 1 1 1 1 SUR7/PalI family Amastin PF07344.6 EFX02005.1 - 0.71 9.4 13.1 2 8.0 9.1 1.7 1 0 0 1 1 1 0 Amastin surface glycoprotein Fig1 PF12351.3 EFX02005.1 - 1.7 8.5 11.4 0.38 10.6 4.1 2.4 3 0 0 3 3 3 0 Ca2+ regulator and membrane fusion protein Fig1 CAP PF00188.21 EFX02006.1 - 8.7e-19 68.2 3.2 8.7e-19 68.2 2.2 1.7 2 0 0 2 2 2 1 Cysteine-rich secretory protein family SAICAR_synt PF01259.13 EFX02007.1 - 1.3e-76 257.0 0.0 1.6e-76 256.7 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase MFS_1 PF07690.11 EFX02009.1 - 6.6e-25 87.5 33.8 6.6e-25 87.5 23.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RskA PF10099.4 EFX02009.1 - 0.19 11.4 3.9 0.6 9.8 0.3 2.9 3 0 0 3 3 3 0 Anti-sigma-K factor rskA adh_short PF00106.20 EFX02010.1 - 2.1e-25 89.5 0.7 2.1e-25 89.5 0.5 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX02010.1 - 1.7e-08 34.5 0.0 2.5e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX02010.1 - 5.9e-08 32.5 1.1 1.9e-07 30.9 0.7 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX02010.1 - 0.0056 16.1 0.2 0.02 14.3 0.0 2.0 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX02010.1 - 0.0072 16.3 0.2 0.021 14.8 0.1 1.8 1 1 0 1 1 1 1 NADH(P)-binding Wax2_C PF12076.3 EFX02010.1 - 0.031 14.0 0.2 2.7 7.6 0.0 2.4 2 0 0 2 2 2 0 WAX2 C-terminal domain Eno-Rase_NADH_b PF12242.3 EFX02010.1 - 0.045 13.5 0.4 0.097 12.4 0.3 1.6 1 1 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RmlD_sub_bind PF04321.12 EFX02010.1 - 0.055 12.3 0.0 0.09 11.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Nup54 PF13874.1 EFX02011.1 - 7.6e-46 155.2 1.0 7.6e-46 155.2 0.7 2.0 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 EFX02011.1 - 2.9e-12 46.8 22.5 4.1e-12 46.3 15.6 1.2 1 0 0 1 1 1 1 Nucleoporin FG repeat region ATP_Ca_trans_C PF12424.3 EFX02011.1 - 0.024 14.9 0.5 0.06 13.7 0.3 1.6 1 0 0 1 1 1 0 Plasma membrane calcium transporter ATPase C terminal Pyr_excise PF03013.9 EFX02011.1 - 0.034 13.9 0.6 0.11 12.2 0.1 1.9 2 0 0 2 2 2 0 Pyrimidine dimer DNA glycosylase FlaC_arch PF05377.6 EFX02011.1 - 0.07 13.0 2.4 0.26 11.2 0.4 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DivIVA PF05103.8 EFX02011.1 - 0.25 11.4 5.8 0.22 11.5 2.7 1.8 1 1 0 1 1 1 0 DivIVA protein FUSC PF04632.7 EFX02011.1 - 0.81 8.0 5.8 0.98 7.7 4.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Tup_N PF08581.5 EFX02011.1 - 0.97 9.6 5.5 0.82 9.9 1.6 2.2 2 0 0 2 2 2 0 Tup N-terminal ApoLp-III PF07464.6 EFX02011.1 - 1.1 9.3 7.2 0.93 9.5 3.2 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) bZIP_1 PF00170.16 EFX02011.1 - 1.1 9.2 5.6 17 5.4 0.3 3.3 2 1 1 3 3 3 0 bZIP transcription factor bZIP_2 PF07716.10 EFX02011.1 - 1.6 8.5 12.3 4.7 7.1 0.6 3.6 4 0 0 4 4 4 0 Basic region leucine zipper Atg14 PF10186.4 EFX02011.1 - 5 5.9 8.3 9.5 5.0 5.8 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Aldo_ket_red PF00248.16 EFX02012.1 - 1.3e-53 181.6 0.0 1.5e-53 181.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PI31_Prot_C PF08577.6 EFX02012.1 - 0.094 13.3 0.1 0.17 12.5 0.1 1.4 1 0 0 1 1 1 0 PI31 proteasome regulator DUF937 PF06078.6 EFX02012.1 - 0.11 12.6 0.5 0.26 11.5 0.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) LSM PF01423.17 EFX02013.1 - 3.1e-19 68.2 0.0 4.1e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EFX02013.1 - 0.028 14.3 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF669 PF05037.8 EFX02013.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF669) NUDIX PF00293.23 EFX02014.1 - 1.1e-09 38.0 0.0 1.4e-06 28.0 0.0 2.1 2 0 0 2 2 2 2 NUDIX domain Mpv17_PMP22 PF04117.7 EFX02015.1 - 1.1e-12 47.3 0.4 1.1e-12 47.3 0.3 2.5 2 1 0 2 2 2 1 Mpv17 / PMP22 family Vezatin PF12632.2 EFX02016.1 - 0.0055 15.8 1.0 0.0055 15.8 0.7 1.7 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes Syntaxin PF00804.20 EFX02016.1 - 0.015 15.4 1.0 0.075 13.2 0.7 2.1 1 1 0 1 1 1 0 Syntaxin HHH_2 PF12826.2 EFX02016.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Asp PF00026.18 EFX02017.1 - 1.4e-67 228.2 14.2 4.9e-67 226.4 9.8 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX02017.1 - 9.3e-09 35.4 0.2 6e-08 32.8 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.1 EFX02017.1 - 0.0021 17.8 0.7 0.59 10.0 0.1 3.0 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Glyco_hydro_98C PF08307.6 EFX02017.1 - 0.36 10.0 4.3 2.1 7.5 0.9 2.5 3 0 0 3 3 3 0 Glycosyl hydrolase family 98 C-terminal domain Asp_protease_2 PF13650.1 EFX02017.1 - 1 9.9 8.6 21 5.6 0.1 4.1 3 2 1 4 4 4 0 Aspartyl protease Fungal_trans_2 PF11951.3 EFX02018.1 - 2.1e-14 52.9 0.0 7.1e-08 31.4 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Ribosomal_L24e PF01246.15 EFX02019.1 - 1.5e-30 104.8 0.5 1.5e-30 104.8 0.3 2.0 2 1 0 2 2 2 1 Ribosomal protein L24e Holin_LLH PF09682.5 EFX02019.1 - 4 7.6 7.3 5.6 7.1 5.1 1.2 1 0 0 1 1 1 0 Phage holin protein (Holin_LLH) Myosin_head PF00063.16 EFX02020.1 - 9.7e-250 830.3 0.3 3.4e-249 828.5 0.0 2.2 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.14 EFX02020.1 - 1.7e-23 82.3 270.7 1.7e-20 72.3 82.5 6.3 3 2 1 4 4 4 1 Myosin tail Filament PF00038.16 EFX02020.1 - 9.6e-05 21.9 12.2 9.6e-05 21.9 8.4 9.3 2 2 6 8 8 8 3 Intermediate filament protein Myosin_N PF02736.14 EFX02020.1 - 0.00013 21.5 0.3 0.0003 20.3 0.2 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_19 PF13245.1 EFX02020.1 - 0.016 14.9 1.3 0.19 11.4 0.0 3.2 3 0 0 3 3 3 0 Part of AAA domain FAD_binding_4 PF01565.18 EFX02021.1 - 4.4e-06 26.2 0.0 0.00013 21.4 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain Aldedh PF00171.17 EFX02023.1 - 6.9e-181 601.6 2.2 1e-180 601.0 1.5 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sulfate_transp PF00916.15 EFX02023.1 - 3.5e-52 177.1 0.4 6.8e-51 172.9 1.4 2.2 2 1 0 2 2 2 1 Sulfate transporter family 5_nucleotid_C PF02872.13 EFX02023.1 - 3.2e-38 131.1 0.0 6.8e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Sulfate_tra_GLY PF13792.1 EFX02023.1 - 4.1e-26 90.4 5.4 1.3e-25 88.8 3.7 1.9 1 0 0 1 1 1 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EFX02023.1 - 7.9e-18 63.9 0.0 1.7e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 EFX02023.1 - 3.9e-05 23.6 0.0 0.00014 21.8 0.0 2.1 1 0 0 1 1 1 1 STAS domain Metallophos PF00149.23 EFX02023.1 - 4.6e-05 22.8 0.1 7.7e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFX02023.1 - 0.0051 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LuxC PF05893.9 EFX02023.1 - 0.013 14.2 0.0 0.027 13.2 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) zf-3CxxC PF13695.1 EFX02024.1 - 6.4e-24 84.0 0.4 8.5e-24 83.6 0.3 1.2 1 0 0 1 1 1 1 Zinc-binding domain Ribosomal_S14 PF00253.16 EFX02025.1 - 1.4e-17 62.8 0.3 3.5e-17 61.5 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Arb2 PF09757.4 EFX02025.1 - 6.3e-16 58.3 0.0 9.2e-16 57.7 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain OPT PF03169.10 EFX02026.1 - 2.5e-159 531.6 42.9 2.9e-159 531.4 29.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein WBP-1 PF11669.3 EFX02026.1 - 0.07 13.2 0.9 0.26 11.3 0.7 2.0 1 0 0 1 1 1 0 WW domain-binding protein 1 Mpv17_PMP22 PF04117.7 EFX02027.1 - 8.5e-11 41.3 4.2 7.6e-10 38.2 2.2 2.2 2 0 0 2 2 2 1 Mpv17 / PMP22 family COesterase PF00135.23 EFX02028.1 - 1e-98 331.4 0.0 1.3e-98 331.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX02028.1 - 3.3e-06 26.8 0.2 6.2e-06 25.9 0.2 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFX02028.1 - 0.0013 17.9 0.2 0.0022 17.2 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Ribosomal_L13 PF00572.13 EFX02029.1 - 1.1e-36 125.7 0.0 1.5e-36 125.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 DUF4129 PF13559.1 EFX02029.1 - 0.067 13.1 0.3 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) LSM PF01423.17 EFX02030.1 - 4.9e-13 48.4 0.1 6.5e-13 48.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain HMA PF00403.21 EFX02031.1 - 3.9e-13 49.3 0.0 7.2e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.15 EFX02031.1 - 2.8e-12 46.9 0.0 4.5e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TPR_17 PF13431.1 EFX02033.1 - 0.0087 16.1 0.0 5 7.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02033.1 - 0.021 14.4 1.0 6 6.6 0.0 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFX02033.1 - 0.061 12.9 9.2 0.49 10.0 0.2 4.6 4 0 0 4 4 4 0 TPR repeat TPR_2 PF07719.12 EFX02033.1 - 0.55 10.2 6.0 14 5.9 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat EBP PF05241.7 EFX02034.1 - 2.3e-08 33.2 4.4 4.6e-08 32.3 3.0 1.5 1 1 0 1 1 1 1 Emopamil binding protein 60KD_IMP PF02096.15 EFX02035.1 - 1.4e-27 96.6 11.6 2.3e-27 95.9 8.0 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein DUF243 PF03103.12 EFX02036.1 - 0.088 12.9 2.1 0.12 12.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF243) SIMPL PF04402.9 EFX02037.1 - 2.2 8.0 10.6 0.19 11.5 3.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF541) APC_CDC26 PF10471.4 EFX02037.1 - 3.2 8.5 8.0 0.8 10.4 2.6 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Sugar_tr PF00083.19 EFX02038.1 - 2.5e-21 75.7 0.7 2e-19 69.4 0.1 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter CFEM PF05730.6 EFX02040.1 - 2e-09 37.1 11.6 2.9e-09 36.5 8.1 1.2 1 0 0 1 1 1 1 CFEM domain AAA PF00004.24 EFX02041.1 - 8.2e-09 35.7 0.4 0.00016 21.9 0.0 2.5 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX02041.1 - 0.0074 16.4 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX02041.1 - 0.5 10.6 3.9 0.71 10.1 0.0 2.9 2 1 0 2 2 2 0 AAA domain Usp PF00582.21 EFX02042.1 - 3.8e-16 59.5 0.1 3.8e-16 59.5 0.0 2.1 2 0 0 2 2 2 1 Universal stress protein family DUF3142 PF11340.3 EFX02042.1 - 0.082 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) SpvB PF03534.8 EFX02042.1 - 0.083 11.9 0.0 0.17 10.8 0.0 1.5 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein CTP_synth_N PF06418.9 EFX02043.1 - 5.5e-116 386.4 0.1 7.3e-116 386.0 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 EFX02043.1 - 7.8e-50 168.9 0.0 1.3e-49 168.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EFX02043.1 - 5.3e-08 32.5 0.3 5.5e-07 29.2 0.1 2.5 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.18 EFX02043.1 - 0.0012 18.2 0.0 0.0032 16.9 0.0 1.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain Cid2 PF09774.4 EFX02045.1 - 9.4e-38 129.6 0.0 1.4e-37 129.1 0.0 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 MFS_1 PF07690.11 EFX02046.1 - 5.1e-26 91.2 58.8 6.4e-20 71.1 21.0 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily Pox_Ag35 PF03286.9 EFX02048.1 - 0.092 12.2 3.3 0.097 12.1 2.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Cut8_N PF14482.1 EFX02048.1 - 0.33 10.9 6.2 1.4 8.9 4.3 2.1 1 1 0 1 1 1 0 Cut8 proteasome-binding domain FAA_hydrolase PF01557.13 EFX02049.1 - 4.9e-52 176.5 0.1 5.4e-52 176.3 0.1 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Arginase PF00491.16 EFX02050.1 - 1.5e-87 293.4 0.0 1.7e-87 293.2 0.0 1.0 1 0 0 1 1 1 1 Arginase family Radical_SAM PF04055.16 EFX02051.1 - 8e-12 45.6 0.0 1.4e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily ApbA_C PF08546.6 EFX02052.1 - 2.6e-33 114.6 0.0 7.1e-33 113.2 0.0 1.7 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EFX02052.1 - 5e-31 107.1 0.0 6.8e-31 106.7 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.17 EFX02052.1 - 0.0032 17.9 0.8 0.039 14.4 0.1 2.4 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold ThiF PF00899.16 EFX02052.1 - 0.015 15.0 1.9 0.06 13.1 0.6 2.2 1 1 1 2 2 2 0 ThiF family FAD_binding_3 PF01494.14 EFX02052.1 - 0.061 12.3 0.1 0.087 11.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.9 EFX02052.1 - 0.12 10.7 0.2 0.18 10.2 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein IlvN PF07991.7 EFX02052.1 - 0.14 11.5 0.6 0.51 9.6 0.0 2.2 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, catalytic domain Phage_CII PF05269.6 EFX02053.1 - 0.016 15.1 0.6 56 3.8 0.0 4.2 1 1 1 3 3 3 0 Bacteriophage CII protein Cleaved_Adhesin PF07675.6 EFX02053.1 - 0.095 12.2 4.9 15 5.1 0.1 3.5 1 1 3 4 4 4 0 Cleaved Adhesin Domain Zfx_Zfy_act PF04704.8 EFX02053.1 - 0.63 8.8 9.9 7.6 5.2 0.2 4.0 1 1 3 5 5 5 0 Zfx / Zfy transcription activation region YCII PF03795.9 EFX02053.1 - 2 8.6 8.6 28 5.0 0.2 3.3 1 1 2 3 3 3 0 YCII-related domain gp12-short_mid PF09089.5 EFX02053.1 - 7.9 6.5 10.3 20 5.1 0.4 3.5 1 1 2 3 3 3 0 Phage short tail fibre protein gp12, middle domain DUF2305 PF10230.4 EFX02054.1 - 5.4e-54 183.3 0.0 6.3e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 EFX02054.1 - 5.2e-06 26.5 1.4 7.6e-06 25.9 1.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX02054.1 - 0.002 17.9 0.0 0.0067 16.1 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX02054.1 - 0.018 14.5 0.0 0.031 13.8 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 EFX02054.1 - 0.034 13.7 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold DOT1 PF08123.8 EFX02055.1 - 1.1e-73 246.9 0.0 1.6e-73 246.4 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 EFX02055.1 - 0.00037 20.4 0.0 0.00075 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02055.1 - 0.0032 17.0 0.0 0.0068 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02055.1 - 0.015 15.8 0.0 0.036 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 EFX02055.1 - 0.039 13.0 0.1 0.067 12.2 0.1 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase AhpC-TSA PF00578.16 EFX02056.1 - 2.7e-33 114.3 0.0 3.6e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFX02056.1 - 6.3e-13 48.4 0.0 8.4e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 EFX02056.1 - 2.9e-12 46.0 0.2 5.6e-12 45.1 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AAR2 PF05282.6 EFX02058.1 - 1e-32 113.4 0.0 2.7e-18 66.0 0.0 2.1 2 0 0 2 2 2 2 AAR2 protein Pex24p PF06398.6 EFX02059.1 - 1.1e-92 310.5 0.0 1.6e-92 310.0 0.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF4097 PF13349.1 EFX02059.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) Cupin_2 PF07883.6 EFX02060.1 - 4e-08 32.6 0.3 5e-07 29.1 0.2 2.3 1 1 0 1 1 1 1 Cupin domain Nuc_deoxyrib_tr PF05014.10 EFX02061.1 - 0.048 13.5 0.0 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase SEP PF08059.8 EFX02062.1 - 1.2e-25 89.5 0.0 2e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.1 EFX02062.1 - 3.3e-12 45.7 0.4 5.5e-12 45.0 0.2 1.4 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 EFX02062.1 - 1.5e-06 28.1 0.0 2.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 UBX domain PGA2 PF07543.7 EFX02062.1 - 8.4 6.1 6.9 10 5.9 3.8 1.8 1 1 1 2 2 2 0 Protein trafficking PGA2 Fungal_trans PF04082.13 EFX02063.1 - 5.5e-17 61.4 0.1 1.3e-16 60.2 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02063.1 - 1.9e-08 34.1 10.7 3.4e-08 33.2 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1212 PF06738.7 EFX02065.1 - 8.9e-49 165.5 15.1 2e-48 164.4 0.3 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 EFX02065.1 - 2.6e-20 72.6 36.5 1.9e-13 50.4 2.6 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF3815) COX14 PF14880.1 EFX02066.1 - 1.1e-18 66.5 0.3 1.8e-18 65.9 0.2 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c assembly DUF1180 PF06679.7 EFX02066.1 - 8.4 6.2 9.6 0.84 9.5 1.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1180) NmrA PF05368.8 EFX02067.1 - 8.2e-21 74.3 0.6 1.1e-20 73.8 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX02067.1 - 9.5e-14 51.8 0.5 1.8e-13 50.8 0.2 1.6 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 EFX02067.1 - 0.00012 21.2 0.5 0.00024 20.1 0.1 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase Epimerase PF01370.16 EFX02067.1 - 0.00035 20.1 0.0 0.002 17.6 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 EFX02067.1 - 0.00069 19.5 0.1 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.14 EFX02067.1 - 0.0071 15.0 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DFP PF04127.10 EFX02067.1 - 0.011 15.3 0.7 0.045 13.3 0.0 2.1 2 1 1 3 3 3 0 DNA / pantothenate metabolism flavoprotein NAD_binding_2 PF03446.10 EFX02067.1 - 0.027 14.2 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EFX02067.1 - 0.06 12.9 0.1 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 EFX02067.1 - 0.074 12.1 0.6 0.88 8.6 0.0 2.7 2 2 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TrkA_N PF02254.13 EFX02067.1 - 0.088 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain DAGK_cat PF00781.19 EFX02068.1 - 5.4e-20 71.1 0.0 1.3e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Mucin PF01456.12 EFX02068.1 - 9.4e-05 22.2 13.9 9.4e-05 22.2 9.6 2.1 2 0 0 2 2 2 1 Mucin-like glycoprotein Dicty_REP PF05086.7 EFX02068.1 - 0.2 9.3 4.8 0.29 8.8 3.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Herpes_UL74 PF07982.7 EFX02068.1 - 3.4 6.2 9.3 1.1 7.8 4.2 1.7 2 0 0 2 2 2 0 Herpes UL74 glycoproteins Sporozoite_P67 PF05642.6 EFX02068.1 - 6.8 4.4 8.8 0.099 10.4 0.8 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF1620 PF07774.8 EFX02072.1 - 2.3e-52 177.3 0.0 3.3e-52 176.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 EFX02072.1 - 3.2e-14 52.9 6.7 1.3e-12 47.7 2.3 2.9 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 EFX02072.1 - 0.00051 19.4 2.1 0.041 13.4 0.1 4.6 6 0 0 6 6 6 1 PQQ enzyme repeat Trans_reg_C PF00486.23 EFX02072.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal DUF479 PF04336.7 EFX02072.1 - 0.22 11.6 0.0 0.45 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF479 HET PF06985.6 EFX02073.1 - 2.6e-21 76.2 0.0 5.5e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FLILHELTA PF10306.4 EFX02074.1 - 4e-26 90.8 0.0 6.7e-26 90.1 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.8 EFX02074.1 - 0.034 14.4 0.3 0.077 13.3 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1279) UDPG_MGDP_dh_N PF03721.9 EFX02075.1 - 5e-48 162.9 0.0 2.4e-30 105.2 0.0 2.9 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 EFX02075.1 - 3.3e-32 110.5 0.0 5.7e-32 109.7 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 EFX02075.1 - 2.6e-22 78.9 0.0 2.8e-17 62.7 0.0 3.3 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.10 EFX02075.1 - 0.02 14.7 0.0 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 EFX02075.1 - 0.077 12.7 0.0 18 5.0 0.0 3.4 3 1 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Saccharop_dh PF03435.13 EFX02075.1 - 0.15 10.9 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase APH PF01636.18 EFX02076.1 - 7.7e-12 45.4 4.2 7.7e-12 45.4 2.9 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFX02076.1 - 0.00038 20.1 0.0 0.00064 19.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase ATP_transf PF09830.4 EFX02077.1 - 1.4e-10 40.7 0.0 3.3e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 ATP adenylyltransferase MCR_beta PF02241.13 EFX02078.1 - 0.13 11.5 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain Zn_clus PF00172.13 EFX02080.1 - 0.0011 18.8 4.6 0.0019 18.0 3.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M20 PF01546.23 EFX02081.1 - 1.8e-31 109.1 0.0 3e-31 108.4 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX02081.1 - 4.7e-13 48.8 0.0 8e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Pkinase PF00069.20 EFX02082.1 - 1.2e-38 132.7 0.0 1.3e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02082.1 - 8.1e-14 51.3 0.0 1.1e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFX02082.1 - 1.6e-05 24.7 0.0 0.0014 18.3 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 EFX02082.1 - 0.053 12.3 0.1 0.08 11.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Mem_trans PF03547.13 EFX02083.1 - 2e-53 181.0 0.1 3.2e-53 180.4 0.0 1.3 1 1 0 1 1 1 1 Membrane transport protein DUF3506 PF12014.3 EFX02084.1 - 9e-35 119.4 0.0 1.9e-34 118.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) DUF1769 PF08588.5 EFX02084.1 - 6.5e-29 99.6 0.2 1.5e-28 98.5 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) F-box-like PF12937.2 EFX02084.1 - 8.5e-08 31.8 1.0 1.8e-07 30.7 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX02084.1 - 1.5e-06 27.6 1.6 3.3e-06 26.6 1.1 1.5 1 0 0 1 1 1 1 F-box domain Epimerase PF01370.16 EFX02085.1 - 3e-05 23.5 0.5 0.00048 19.6 0.3 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFX02085.1 - 6.8e-05 21.6 0.0 0.00012 20.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFX02085.1 - 0.00091 18.2 0.0 0.0017 17.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EFX02085.1 - 0.077 12.9 0.5 0.16 11.9 0.3 1.5 1 0 0 1 1 1 0 short chain dehydrogenase FAD_binding_3 PF01494.14 EFX02086.1 - 6e-17 61.7 7.6 5.5e-12 45.4 0.1 3.0 3 1 0 3 3 3 2 FAD binding domain DAO PF01266.19 EFX02086.1 - 2.8e-09 36.3 2.0 5.3e-05 22.2 0.5 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFX02086.1 - 0.00041 20.7 0.8 0.00095 19.5 0.6 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX02086.1 - 0.00082 19.3 0.4 0.0027 17.7 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX02086.1 - 0.0012 18.6 2.2 0.0041 16.8 0.2 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding Amino_oxidase PF01593.19 EFX02086.1 - 0.004 16.2 0.0 0.011 14.8 0.0 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.9 EFX02086.1 - 0.091 11.2 1.2 0.13 10.6 0.8 1.2 1 0 0 1 1 1 0 HI0933-like protein Glyco_transf_90 PF05686.7 EFX02087.1 - 1.9e-14 53.2 0.5 3e-12 45.9 0.1 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 90 Peptidase_C36 PF05415.6 EFX02088.1 - 0.13 12.1 0.1 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase Peptidase_C1_2 PF03051.10 EFX02089.1 - 3.4e-139 464.1 0.0 4.7e-139 463.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 EFX02089.1 - 3.7e-05 23.7 0.1 0.34 10.7 0.0 2.3 2 0 0 2 2 2 2 Papain family cysteine protease UL11 PF11094.3 EFX02090.1 - 0.12 12.2 0.3 1.5 8.6 0.0 2.7 2 0 0 2 2 2 0 Membrane-associated tegument protein Lipoxygenase PF00305.14 EFX02092.1 - 7.1e-53 179.6 4.1 1.8e-52 178.2 2.8 1.5 1 1 0 1 1 1 1 Lipoxygenase ATP_synt_I PF03899.10 EFX02093.1 - 0.0074 16.4 0.3 0.0099 16.0 0.2 1.3 1 1 0 1 1 1 1 ATP synthase I chain EamA PF00892.15 EFX02093.1 - 0.02 14.8 8.5 0.023 14.7 5.9 1.1 1 0 0 1 1 1 0 EamA-like transporter family YhhN PF07947.9 EFX02093.1 - 0.036 13.4 0.7 0.042 13.2 0.5 1.1 1 0 0 1 1 1 0 YhhN-like protein PgaD PF13994.1 EFX02093.1 - 0.077 12.4 0.0 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 PgaD-like protein TPT PF03151.11 EFX02093.1 - 0.14 11.8 6.5 0.17 11.4 4.5 1.1 1 0 0 1 1 1 0 Triose-phosphate Transporter family PRRSV_Env PF02340.10 EFX02093.1 - 0.51 9.4 2.7 0.68 9.0 1.9 1.1 1 0 0 1 1 1 0 PRRSV putative envelope protein IncA PF04156.9 EFX02093.1 - 4.1 6.9 7.8 5 6.6 5.1 1.4 1 1 0 1 1 1 0 IncA protein CTP_transf_1 PF01148.15 EFX02094.1 - 7.4e-79 265.0 31.5 9.1e-79 264.7 21.8 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family RhoGAP PF00620.22 EFX02095.1 - 3.5e-47 159.8 0.0 7.3e-47 158.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.18 EFX02095.1 - 8.3e-14 51.5 0.1 2.1e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain 4HBT_3 PF13622.1 EFX02096.1 - 2.1e-43 148.9 4.9 4.3e-43 147.9 3.4 1.5 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EFX02096.1 - 4.2e-20 71.7 0.0 1.4e-09 37.7 0.0 3.7 3 1 0 3 3 3 3 Acyl-CoA thioesterase Peptidase_S28 PF05577.7 EFX02097.1 - 2.6e-35 121.8 0.0 3e-34 118.3 0.0 2.2 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_5 PF12695.2 EFX02097.1 - 0.0059 16.3 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Pro-kuma_activ PF09286.6 EFX02098.1 - 2.7e-23 82.5 0.0 4.8e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFX02098.1 - 6.6e-09 35.3 0.1 1.1e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 Subtilase family TRI12 PF06609.8 EFX02099.1 - 0.078 11.1 1.2 0.09 10.9 0.9 1.0 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Pro-kuma_activ PF09286.6 EFX02100.1 - 1.3e-47 161.4 0.1 2.9e-47 160.3 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFX02100.1 - 8e-07 28.4 3.3 1.3e-06 27.8 2.3 1.4 1 0 0 1 1 1 1 Subtilase family NUDIX PF00293.23 EFX02101.1 - 9.5e-17 60.9 0.5 2.6e-16 59.4 0.3 1.7 1 1 0 1 1 1 1 NUDIX domain SSF PF00474.12 EFX02101.1 - 1.2e-15 57.0 31.4 1.2e-15 57.0 21.8 1.4 2 0 0 2 2 2 1 Sodium:solute symporter family Fijivirus_P9-2 PF06837.6 EFX02101.1 - 0.17 10.9 3.2 1.6 7.8 0.6 2.4 2 0 0 2 2 2 0 Fijivirus P9-2 protein AA_permease PF00324.16 EFX02102.1 - 1.3e-99 333.7 43.4 1.6e-99 333.4 30.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX02102.1 - 1.6e-27 96.1 44.7 1.9e-27 95.8 31.0 1.1 1 0 0 1 1 1 1 Amino acid permease WD40 PF00400.27 EFX02103.1 - 3.3e-42 140.8 23.2 5.6e-11 41.8 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ThuA PF06283.6 EFX02104.1 - 2.2e-47 161.5 0.0 1.3e-45 155.7 0.0 2.0 1 1 0 1 1 1 1 Trehalose utilisation ABC_tran PF00005.22 EFX02105.1 - 1.3e-45 155.0 0.0 7.4e-23 81.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 EFX02105.1 - 1.1e-20 73.1 3.1 1.1e-20 73.1 2.1 3.0 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.1 EFX02105.1 - 2.6e-19 70.2 0.3 0.00027 20.9 0.0 4.3 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 EFX02105.1 - 2.8e-12 46.3 0.1 3.2e-05 23.2 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EFX02105.1 - 4e-09 35.8 0.1 0.00084 18.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EFX02105.1 - 1.2e-08 35.5 4.0 0.063 13.6 0.0 3.8 3 1 0 3 3 3 2 AAA domain AAA_17 PF13207.1 EFX02105.1 - 1.3e-06 29.2 0.1 0.019 15.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EFX02105.1 - 3e-06 27.5 0.0 0.024 14.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFX02105.1 - 3.9e-06 26.1 0.0 0.0056 15.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX02105.1 - 4.7e-06 26.7 0.0 0.15 12.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EFX02105.1 - 2e-05 24.5 0.0 0.091 12.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX02105.1 - 3.6e-05 23.8 0.3 0.11 12.4 0.0 3.2 3 1 0 3 3 2 2 AAA ATPase domain MMR_HSR1 PF01926.18 EFX02105.1 - 4.9e-05 23.2 0.0 0.082 12.8 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 EFX02105.1 - 0.00013 22.4 0.0 0.52 10.8 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_15 PF13175.1 EFX02105.1 - 0.00013 21.1 0.0 0.09 11.8 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain RNA_helicase PF00910.17 EFX02105.1 - 0.00014 21.9 0.7 0.9 9.7 0.0 3.2 3 0 0 3 3 3 2 RNA helicase NACHT PF05729.7 EFX02105.1 - 0.00015 21.4 0.1 0.63 9.6 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.1 EFX02105.1 - 0.00016 21.6 0.0 0.16 11.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFX02105.1 - 0.00027 21.1 0.0 0.88 9.7 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX02105.1 - 0.00047 19.8 0.1 0.91 9.2 0.1 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 EFX02105.1 - 0.00062 19.3 0.4 0.93 8.8 0.1 2.9 3 0 0 3 3 3 2 AAA-like domain Arch_ATPase PF01637.13 EFX02105.1 - 0.0015 18.2 0.4 1.8 8.1 0.0 3.0 3 0 0 3 3 3 1 Archaeal ATPase AAA_25 PF13481.1 EFX02105.1 - 0.0016 17.9 0.0 0.46 9.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.17 EFX02105.1 - 0.0034 16.2 0.0 0.41 9.4 0.0 2.6 3 0 0 3 3 2 1 NB-ARC domain MobB PF03205.9 EFX02105.1 - 0.0044 16.7 0.3 0.13 11.9 0.1 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 EFX02105.1 - 0.0045 16.8 0.0 1.6 8.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 EFX02105.1 - 0.0075 16.1 1.3 0.34 10.8 0.1 3.8 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit DUF2813 PF11398.3 EFX02105.1 - 0.023 13.7 0.1 6 5.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) AAA_13 PF13166.1 EFX02105.1 - 0.025 13.0 0.0 7.8 4.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.4 EFX02105.1 - 0.03 13.8 0.7 2 7.8 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 EFX02105.1 - 0.039 13.7 0.7 5.9 6.6 0.0 3.3 3 1 0 3 3 3 0 Dynamin family DAP3 PF10236.4 EFX02105.1 - 0.048 12.5 1.5 7.6 5.3 0.0 3.1 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 DUF815 PF05673.8 EFX02105.1 - 0.053 12.4 0.9 4.7 6.0 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF815) DUF87 PF01935.12 EFX02105.1 - 0.059 13.1 0.4 13 5.4 0.0 2.9 3 0 0 3 3 2 0 Domain of unknown function DUF87 ATP-synt_ab PF00006.20 EFX02105.1 - 0.06 12.8 0.0 0.61 9.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 EFX02105.1 - 0.076 12.7 0.0 4.1 7.0 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.1 EFX02105.1 - 1.3 8.5 4.6 9.4 5.7 0.0 3.4 4 0 0 4 4 4 0 AAA domain Synaptobrevin PF00957.16 EFX02106.1 - 3.6e-33 113.0 0.7 4.3e-33 112.7 0.5 1.1 1 0 0 1 1 1 1 Synaptobrevin UQ_con PF00179.21 EFX02107.1 - 1.2e-38 131.7 0.0 1.3e-38 131.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX02107.1 - 0.00013 21.7 0.0 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 EFX02107.1 - 0.0079 15.8 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.17 EFX02107.1 - 0.025 14.4 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain ERG4_ERG24 PF01222.12 EFX02108.1 - 7.6e-170 565.0 1.1 9e-170 564.8 0.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 EFX02108.1 - 0.0009 18.5 1.2 0.0026 17.0 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF2196 PF09962.4 EFX02109.1 - 7.3e-24 83.3 1.8 1.4e-23 82.3 1.2 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) zf-Di19 PF05605.7 EFX02109.1 - 0.11 12.6 0.4 0.17 12.0 0.3 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 EFX02109.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Peptidase_M61 PF05299.7 EFX02110.1 - 1.1e-29 102.8 0.1 4.7e-29 100.8 0.0 2.1 2 0 0 2 2 2 1 M61 glycyl aminopeptidase Peptidase_MA_2 PF13485.1 EFX02110.1 - 9.6e-07 28.8 0.3 5.5e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase MA superfamily PDZ_2 PF13180.1 EFX02110.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Pal1 PF08316.6 EFX02111.1 - 9.8e-17 61.7 0.1 4e-16 59.7 0.1 2.0 1 1 0 1 1 1 1 Pal1 cell morphology protein DUF3720 PF12517.3 EFX02111.1 - 0.095 13.4 0.8 0.23 12.1 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) Ras PF00071.17 EFX02112.1 - 4.8e-42 143.0 0.0 6.2e-42 142.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX02112.1 - 1.2e-08 35.5 0.0 1.6e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX02112.1 - 0.00073 18.8 0.0 0.0031 16.7 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF3138 PF11336.3 EFX02112.1 - 0.046 11.9 0.8 0.23 9.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Ank_4 PF13637.1 EFX02113.1 - 1.6e-15 57.1 1.9 7.3e-08 32.7 0.1 4.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX02113.1 - 7.5e-13 48.6 0.5 1e-07 32.1 0.1 3.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFX02113.1 - 7e-11 42.0 0.6 0.00022 21.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 EFX02113.1 - 1.2e-10 40.6 3.5 0.0002 21.0 0.0 4.5 4 1 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 EFX02113.1 - 1.8e-09 36.8 2.2 0.0075 16.4 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.8 EFX02113.1 - 0.00016 21.2 0.3 0.00075 19.0 0.2 2.1 1 1 0 1 1 1 1 KilA-N domain Macoilin PF09726.4 EFX02113.1 - 0.0053 15.1 0.3 0.0065 14.8 0.2 1.4 1 0 0 1 1 1 1 Transmembrane protein AAA_13 PF13166.1 EFX02113.1 - 0.3 9.5 1.7 0.57 8.5 1.2 1.3 1 0 0 1 1 1 0 AAA domain Hrs_helical PF12210.3 EFX02113.1 - 6.7 7.0 11.1 0.079 13.2 2.1 1.9 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Methyltransf_23 PF13489.1 EFX02114.1 - 3.1e-10 40.0 0.0 2.5e-09 37.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02114.1 - 2.5e-08 34.3 0.0 2e-07 31.3 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX02114.1 - 7.6e-06 25.2 0.1 0.00037 19.7 0.0 2.2 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFX02114.1 - 0.00019 21.0 0.0 0.0073 15.9 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFX02114.1 - 0.00098 18.8 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.7 EFX02114.1 - 0.012 16.0 0.0 0.042 14.3 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase domain UnbV_ASPIC PF07593.7 EFX02114.1 - 0.097 12.3 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 ASPIC and UnbV Methyltransf_18 PF12847.2 EFX02114.1 - 0.1 13.2 0.2 7.9 7.1 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain DUF1838 PF08894.6 EFX02115.1 - 0.053 12.7 0.0 0.061 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1838) NMO PF03060.10 EFX02116.1 - 3.3e-27 95.5 11.8 1e-18 67.6 4.8 2.9 2 1 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.20 EFX02116.1 - 3.1e-05 23.0 0.0 0.039 12.8 1.3 2.1 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 EFX02116.1 - 0.0022 16.9 3.5 0.62 8.9 1.2 2.1 1 1 1 2 2 2 2 Conserved region in glutamate synthase FMN_dh PF01070.13 EFX02116.1 - 0.01 14.7 5.7 0.017 13.9 3.9 1.4 1 1 0 1 1 1 0 FMN-dependent dehydrogenase GYF PF02213.11 EFX02117.1 - 2.7e-18 65.2 0.1 2.7e-18 65.2 0.0 3.1 4 0 0 4 4 4 1 GYF domain TPR_11 PF13414.1 EFX02117.1 - 9.8e-12 44.3 0.4 6.4e-10 38.5 0.2 3.8 4 0 0 4 4 4 1 TPR repeat TPR_16 PF13432.1 EFX02117.1 - 3.3e-10 40.3 0.9 3.3e-10 40.3 0.6 4.4 4 0 0 4 4 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02117.1 - 1.9e-06 27.2 0.1 0.15 11.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02117.1 - 6.4e-06 25.6 6.3 0.034 14.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02117.1 - 8.5e-05 22.4 6.0 0.018 15.0 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFX02117.1 - 0.00017 21.9 1.0 0.003 18.0 0.1 6.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFX02117.1 - 0.0013 18.3 0.2 0.37 10.7 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 EFX02117.1 - 0.0036 17.1 0.4 0.013 15.3 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02117.1 - 0.0036 16.9 0.0 0.34 10.7 0.0 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.4 EFX02117.1 - 0.087 12.2 0.5 2.2 7.6 0.1 2.8 3 0 0 3 3 3 0 26S proteasome subunit RPN7 Dynamin_M PF01031.15 EFX02117.1 - 1 8.0 0.0 1.8 7.2 0.0 1.3 1 0 0 1 1 1 0 Dynamin central region Methyltransf_23 PF13489.1 EFX02118.1 - 3.3e-22 78.9 0.0 5e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02118.1 - 9.9e-12 45.1 0.0 2.6e-11 43.8 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02118.1 - 6.7e-09 36.1 0.0 6.9e-08 32.8 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02118.1 - 7.5e-09 35.3 0.0 7.8e-08 32.0 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02118.1 - 4e-08 33.8 0.0 5.7e-07 30.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX02118.1 - 7.2e-05 22.0 0.0 0.00085 18.4 0.0 2.3 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX02118.1 - 0.00011 22.4 0.0 0.00047 20.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFX02118.1 - 0.00034 20.1 0.0 0.00054 19.4 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_4 PF02390.12 EFX02118.1 - 0.00047 19.2 0.0 0.001 18.1 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 EFX02118.1 - 0.00067 18.8 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EFX02118.1 - 0.00096 19.1 0.0 0.0033 17.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX02118.1 - 0.0022 18.0 0.2 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 FtsJ-like methyltransferase MTS PF05175.9 EFX02118.1 - 0.0047 16.3 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DUF938 PF06080.7 EFX02118.1 - 0.061 12.8 0.0 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Tape_meas_lam_C PF09718.5 EFX02119.1 - 0.53 10.2 41.8 0.1 12.5 1.0 5.2 1 1 4 5 5 5 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) 2-Hacid_dh_C PF02826.14 EFX02120.1 - 1.4e-38 131.7 0.0 5.1e-38 129.9 0.0 1.9 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX02120.1 - 3.8e-19 68.4 0.0 5.1e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_10 PF13460.1 EFX02120.1 - 0.0031 17.5 1.5 0.011 15.7 0.4 2.0 2 0 0 2 2 2 1 NADH(P)-binding AdoHcyase_NAD PF00670.16 EFX02120.1 - 0.0046 16.8 0.3 0.011 15.5 0.2 1.6 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.15 EFX02120.1 - 0.0055 16.7 0.2 0.019 15.0 0.1 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase XdhC_C PF13478.1 EFX02120.1 - 0.0064 16.8 0.0 0.039 14.2 0.0 2.1 2 0 0 2 2 2 1 XdhC Rossmann domain IlvN PF07991.7 EFX02120.1 - 0.0069 15.7 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.12 EFX02120.1 - 0.018 15.4 0.1 0.054 13.9 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 EFX02120.1 - 0.033 13.6 0.5 0.067 12.6 0.4 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 EFX02120.1 - 0.47 10.2 2.4 1.3 8.8 1.1 2.0 2 0 0 2 2 2 0 ThiF family Peptidase_M20 PF01546.23 EFX02121.1 - 6.2e-25 87.8 0.5 8.1e-25 87.4 0.4 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX02121.1 - 3.5e-06 26.7 0.2 8.4e-06 25.5 0.1 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFX02121.1 - 0.018 14.7 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Cu-oxidase_3 PF07732.10 EFX02122.1 - 2.9e-45 152.7 5.4 4.4e-43 145.7 1.5 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX02122.1 - 2.4e-38 130.7 7.1 1.9e-36 124.5 0.1 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EFX02122.1 - 1.6e-32 112.6 0.2 3.8e-32 111.3 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Ldh_1_N PF00056.18 EFX02123.1 - 5.8e-44 149.3 0.1 1.1e-43 148.4 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 EFX02123.1 - 8.5e-39 133.0 0.0 1.3e-38 132.4 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 EFX02123.1 - 0.0012 17.6 0.0 0.0016 17.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.11 EFX02123.1 - 0.019 14.2 0.1 0.6 9.3 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Semialdhyde_dh PF01118.19 EFX02123.1 - 0.041 14.2 0.5 0.35 11.1 0.0 2.6 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EFX02123.1 - 0.11 12.3 0.0 0.83 9.5 0.0 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Amidohydro_2 PF04909.9 EFX02124.1 - 1.3e-40 139.7 0.2 1.4e-40 139.6 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase NDUF_B7 PF05676.8 EFX02125.1 - 4.3e-31 106.1 2.9 5e-31 105.9 2.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.5 EFX02125.1 - 0.1 12.4 2.5 0.13 12.0 1.8 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Xan_ur_permease PF00860.15 EFX02126.1 - 2.4e-24 85.5 28.8 2.5e-22 78.9 19.9 2.3 1 1 0 1 1 1 1 Permease family PC_rep PF01851.17 EFX02127.1 - 2e-37 125.3 20.1 7e-06 25.9 0.0 9.5 10 0 0 10 10 10 7 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EFX02127.1 - 3.3e-18 65.7 1.5 7.6e-12 45.3 0.0 6.4 5 1 2 7 7 7 3 HEAT repeats HEAT PF02985.17 EFX02127.1 - 1.9e-08 33.6 2.1 2.8 8.2 0.0 6.5 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 EFX02127.1 - 1.5e-05 25.3 5.1 0.0023 18.3 0.0 5.3 4 1 0 5 5 5 1 HEAT-like repeat Pkinase PF00069.20 EFX02128.1 - 6.1e-60 202.5 0.0 8.7e-60 202.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02128.1 - 5.4e-27 94.4 0.0 4.2e-25 88.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFX02128.1 - 0.0002 21.1 0.8 0.022 14.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 EFX02128.1 - 0.003 16.5 0.4 0.0092 14.9 0.3 1.7 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFX02128.1 - 0.043 12.6 0.0 0.063 12.0 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 ACPS PF01648.15 EFX02129.1 - 4e-05 23.4 0.0 8.3e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily FHA PF00498.21 EFX02130.1 - 5.5e-15 55.2 0.0 1.3e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 EFX02130.1 - 4.6e-07 29.5 8.4 9.4e-07 28.5 5.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFX02130.1 - 0.00011 22.2 2.8 0.00021 21.3 1.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EFX02130.1 - 0.00074 19.1 4.6 0.0014 18.2 3.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX02130.1 - 0.001 18.6 7.7 0.0019 17.8 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 EFX02130.1 - 0.0028 17.3 4.5 0.0052 16.4 3.1 1.5 1 0 0 1 1 1 1 PHD-finger zf-RING_5 PF14634.1 EFX02130.1 - 0.011 15.4 6.0 0.019 14.6 4.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-Apc11 PF12861.2 EFX02130.1 - 0.013 15.2 1.4 0.025 14.3 1.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.6 EFX02130.1 - 0.2 11.7 4.8 0.39 10.7 3.3 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.1 EFX02130.1 - 0.22 11.6 9.4 0.42 10.6 6.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPT PF03151.11 EFX02132.1 - 6.7e-23 81.0 9.5 6.7e-23 81.0 6.6 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 EFX02132.1 - 1.8e-13 50.1 16.7 2.9e-13 49.3 11.6 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 EFX02132.1 - 6.8e-05 22.9 23.3 0.00037 20.5 3.4 2.9 2 1 1 3 3 3 2 EamA-like transporter family SR-25 PF10500.4 EFX02132.1 - 2.4 7.5 12.6 3.3 7.1 8.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Brix PF04427.13 EFX02133.1 - 7e-57 192.1 0.0 9.3e-57 191.7 0.0 1.1 1 0 0 1 1 1 1 Brix domain DUF3633 PF12315.3 EFX02133.1 - 0.03 13.6 0.2 0.065 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) WD40 PF00400.27 EFX02134.1 - 7.9e-12 44.5 6.0 0.00018 21.2 0.0 5.1 6 0 0 6 6 6 3 WD domain, G-beta repeat Aldedh PF00171.17 EFX02135.1 - 7.8e-91 304.7 0.1 2.1e-48 164.8 0.1 2.1 1 1 1 2 2 2 2 Aldehyde dehydrogenase family MFS_1 PF07690.11 EFX02135.1 - 2.2e-33 115.4 31.1 2.2e-33 115.4 21.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02135.1 - 5e-09 35.2 18.6 1e-08 34.2 12.9 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter LuxC PF05893.9 EFX02135.1 - 0.13 10.9 0.1 0.37 9.4 0.0 1.8 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) 4HBT_2 PF13279.1 EFX02136.1 - 0.019 15.4 0.0 0.038 14.4 0.0 1.5 1 0 0 1 1 1 0 Thioesterase-like superfamily FAR1 PF03101.10 EFX02137.1 - 0.00025 21.5 0.1 0.0004 20.8 0.1 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.6 EFX02137.1 - 0.00036 20.6 0.1 0.00052 20.1 0.1 1.3 1 0 0 1 1 1 1 Transcription factor AFT Baculo_PEP_C PF04513.7 EFX02137.1 - 0.00059 19.6 0.0 0.0017 18.2 0.0 1.8 2 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 EFX02137.1 - 0.028 14.2 0.1 0.13 12.0 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HSBP1 PF06825.7 EFX02137.1 - 0.043 13.3 0.3 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Matrilin_ccoil PF10393.4 EFX02137.1 - 0.052 12.9 0.0 2 7.8 0.0 2.8 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Sec10 PF07393.6 EFX02137.1 - 0.059 11.5 0.0 0.077 11.1 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 QLQ PF08880.6 EFX02138.1 - 0.13 11.7 0.5 11 5.5 0.0 3.1 3 0 0 3 3 3 0 QLQ MoaE PF02391.12 EFX02139.1 - 8.2e-33 112.6 0.0 9.9e-33 112.4 0.0 1.1 1 0 0 1 1 1 1 MoaE protein Dabb PF07876.7 EFX02140.1 - 1.7e-15 57.2 0.0 2.2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Cyt-b5 PF00173.23 EFX02141.1 - 6.8e-15 54.6 0.0 9.4e-15 54.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF3636 PF12331.3 EFX02143.1 - 2.4e-29 101.8 0.0 5.5e-29 100.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) DUF4407 PF14362.1 EFX02143.1 - 0.6 9.0 5.8 0.93 8.3 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mitofilin PF09731.4 EFX02143.1 - 1.9 7.0 9.7 2.7 6.5 6.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Aminotran_3 PF00202.16 EFX02144.1 - 1.5e-77 260.7 0.4 1.9e-77 260.3 0.3 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 EFX02144.1 - 0.011 14.8 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase Polysacc_synt_4 PF04669.8 EFX02145.1 - 2.6e-26 92.1 1.8 1.3e-25 89.8 1.3 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis TIMELESS_C PF05029.8 EFX02145.1 - 0.024 13.6 0.4 0.026 13.4 0.2 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region Kelch_4 PF13418.1 EFX02146.1 - 9.2e-19 66.9 0.1 6.4e-08 32.2 0.0 5.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.1 EFX02146.1 - 8.9e-18 63.9 4.0 1.8e-09 37.4 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 EFX02146.1 - 2.5e-11 43.2 3.5 0.00021 21.1 0.0 4.3 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 EFX02146.1 - 6.7e-10 38.3 0.1 0.003 17.2 0.0 4.0 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 EFX02146.1 - 1.3e-09 37.4 0.3 0.005 16.3 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 EFX02146.1 - 6e-09 35.6 1.1 0.081 13.1 0.0 4.9 5 0 0 5 5 5 3 Kelch motif BTB PF00651.26 EFX02146.1 - 0.0011 18.8 0.0 0.069 13.1 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain Abhydrolase_6 PF12697.2 EFX02147.1 - 6.3e-07 29.4 0.1 8.2e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX02147.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family RskA PF10099.4 EFX02148.1 - 0.022 14.4 0.1 0.022 14.4 0.1 1.5 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DnaJ-X PF14308.1 EFX02149.1 - 1.5e-70 236.5 1.9 1.5e-70 236.5 1.3 2.0 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 EFX02149.1 - 3.6e-26 90.6 1.0 9.2e-26 89.3 0.7 1.8 1 0 0 1 1 1 1 DnaJ domain SLX9 PF15341.1 EFX02149.1 - 0.39 11.1 11.2 0.24 11.8 0.5 3.0 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 Inositol_P PF00459.20 EFX02152.1 - 3.4e-35 121.6 0.4 9.6e-35 120.1 0.3 1.8 1 1 0 1 1 1 1 Inositol monophosphatase family MFS_1 PF07690.11 EFX02153.1 - 6.6e-34 117.1 32.0 9.5e-34 116.6 22.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02153.1 - 2.1e-09 36.4 8.8 2.1e-09 36.4 6.1 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter NARP1 PF12569.3 EFX02154.1 - 4.6e-179 596.4 24.8 5.8e-179 596.1 9.9 2.6 3 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_17 PF13431.1 EFX02154.1 - 2e-11 43.1 5.7 0.14 12.3 0.0 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFX02154.1 - 5.1e-09 35.6 30.7 3.9e-06 26.4 0.3 7.0 6 1 2 8 8 8 3 TPR repeat TPR_16 PF13432.1 EFX02154.1 - 3.6e-08 33.8 3.0 0.0003 21.3 1.4 9.8 9 1 2 11 11 9 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFX02154.1 - 6.1e-08 32.8 43.1 0.00014 22.1 0.6 8.6 9 2 1 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02154.1 - 7.2e-07 29.0 23.1 0.014 15.3 0.1 7.2 4 1 2 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02154.1 - 1.6e-06 27.5 33.6 0.00022 20.8 0.2 10.1 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFX02154.1 - 1.8e-05 24.4 0.6 1.8e-05 24.4 0.4 5.9 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02154.1 - 3.2e-05 23.3 0.3 3.2e-05 23.3 0.2 7.3 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02154.1 - 0.00027 20.4 1.1 0.01 15.5 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX02154.1 - 0.00069 20.0 0.1 0.00069 20.0 0.1 12.4 9 3 6 15 15 14 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EFX02154.1 - 0.036 13.9 9.5 4.3 7.3 0.1 4.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.9 EFX02154.1 - 1.3 9.6 15.7 0.68 10.5 0.2 6.5 6 0 0 6 6 5 0 Tetratricopeptide repeat NAM-associated PF14303.1 EFX02154.1 - 4 7.7 15.0 4.2 7.6 4.4 2.8 2 1 1 3 3 3 0 No apical meristem-associated C-terminal domain TPR_7 PF13176.1 EFX02154.1 - 6.7 6.7 11.7 2.4 8.1 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Hydrolase PF00702.21 EFX02155.1 - 5.1e-22 79.3 0.0 2.8e-21 76.9 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EFX02155.1 - 5.8e-21 75.5 0.1 1.2e-20 74.5 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EFX02155.1 - 1.1e-18 67.1 0.0 4.5e-18 65.1 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 EFX02155.1 - 1.7e-05 24.6 0.0 0.00013 21.8 0.0 2.2 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFX02155.1 - 0.0026 17.4 0.0 0.041 13.4 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase 4HBT PF03061.17 EFX02156.1 - 2.4e-08 33.9 0.1 5e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Pex14_N PF04695.8 EFX02156.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IncA PF04156.9 EFX02158.1 - 0.0078 15.8 0.1 0.014 14.9 0.1 1.3 1 0 0 1 1 1 1 IncA protein LRR_4 PF12799.2 EFX02160.1 - 6.2e-10 38.4 5.5 5.8e-09 35.3 0.9 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX02160.1 - 2.1e-09 36.9 4.1 4.2e-09 36.0 2.8 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.28 EFX02160.1 - 2.7e-05 23.5 6.7 0.042 13.8 0.0 3.7 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_7 PF13504.1 EFX02160.1 - 0.00065 19.4 7.9 0.094 12.9 0.1 4.0 4 0 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 EFX02160.1 - 0.21 11.7 2.2 25 5.3 0.2 3.2 3 0 0 3 3 3 0 Leucine Rich repeat DUF2890 PF11081.3 EFX02161.1 - 3.9 7.4 34.0 1.3 9.0 12.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2890) Trypsin_2 PF13365.1 EFX02162.1 - 0.0022 17.9 0.0 0.008 16.1 0.0 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 EFX02162.1 - 0.051 13.1 0.9 0.1 12.1 0.6 1.7 1 1 0 1 1 1 0 Trypsin Cu-oxidase_3 PF07732.10 EFX02163.1 - 4.5e-46 155.4 1.0 1.6e-43 147.2 0.0 3.3 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX02163.1 - 3.3e-34 117.3 3.5 5.5e-31 106.9 0.2 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.17 EFX02163.1 - 7.4e-13 48.7 0.0 3.9e-12 46.3 0.0 2.0 2 0 0 2 2 2 1 Multicopper oxidase Fungal_trans PF04082.13 EFX02164.1 - 2.7e-08 33.0 0.0 4.5e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CENP-L PF13092.1 EFX02165.1 - 1.4e-46 158.2 0.0 2.4e-46 157.4 0.0 1.4 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 NAD_binding_7 PF13241.1 EFX02165.1 - 3.2e-34 117.2 0.0 7.5e-34 116.0 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 EFX02165.1 - 8.6e-27 92.2 0.0 1.4e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 EFX02165.1 - 2.4e-14 51.9 0.1 4.6e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.15 EFX02165.1 - 0.065 13.3 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.16 EFX02165.1 - 0.12 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ThiF PF00899.16 EFX02165.1 - 0.15 11.9 1.2 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 ThiF family MFS_1 PF07690.11 EFX02166.1 - 2.2e-35 122.0 55.0 3.6e-23 81.8 29.5 3.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Tmemb_18A PF09771.4 EFX02166.1 - 1 9.3 6.9 0.63 10.0 2.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 188 DAHP_synth_1 PF00793.15 EFX02167.1 - 2.2e-100 334.8 0.1 2.5e-100 334.6 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Vps35 PF03635.12 EFX02169.1 - 0 1013.1 0.2 0 1012.9 0.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Mito_carr PF00153.22 EFX02170.1 - 3.2e-46 154.9 4.7 5.5e-19 67.6 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3123 PF11321.3 EFX02170.1 - 1.9 8.7 8.1 1.7 8.9 0.9 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3123) Pyridox_oxidase PF01243.15 EFX02171.1 - 1.9e-12 47.0 0.1 9.3e-12 44.8 0.1 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 EFX02171.1 - 0.074 12.8 0.0 0.68 9.7 0.0 2.0 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase SPA PF08616.5 EFX02171.1 - 0.12 12.1 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Stabilization of polarity axis RRM_3 PF08777.6 EFX02172.1 - 0.051 13.4 0.1 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif Myb_DNA-bind_6 PF13921.1 EFX02173.1 - 9.1e-07 28.8 0.3 3.5e-06 27.0 0.2 2.0 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFX02173.1 - 1e-05 25.4 0.2 0.00082 19.3 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.3 EFX02173.1 - 0.044 13.6 0.7 0.36 10.7 0.5 2.2 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Glycos_transf_3 PF00591.16 EFX02173.1 - 0.089 12.1 0.1 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain ABC_tran PF00005.22 EFX02174.1 - 3.1e-46 157.0 0.0 1.3e-23 83.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFX02174.1 - 1.7e-28 99.8 23.9 5.6e-18 65.3 7.6 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.1 EFX02174.1 - 2.3e-10 40.9 0.0 0.37 10.6 0.0 4.1 4 0 0 4 4 4 3 AAA domain AAA_16 PF13191.1 EFX02174.1 - 3.4e-08 33.6 0.1 0.00012 22.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 EFX02174.1 - 2.4e-07 30.9 0.0 0.015 15.4 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX02174.1 - 4e-06 26.2 0.1 0.12 11.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 EFX02174.1 - 2.4e-05 24.8 0.3 0.088 13.3 0.1 2.4 2 0 0 2 2 2 2 Miro-like protein SMC_N PF02463.14 EFX02174.1 - 2.6e-05 23.5 0.7 1.3 8.1 0.0 4.1 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 EFX02174.1 - 5.3e-05 22.7 0.1 0.11 11.8 0.0 3.2 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EFX02174.1 - 6e-05 22.2 0.1 0.095 11.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EFX02174.1 - 0.00035 20.5 0.1 1.2 9.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Arch_ATPase PF01637.13 EFX02174.1 - 0.00039 20.1 0.0 0.0073 16.0 0.0 2.3 2 0 0 2 2 2 1 Archaeal ATPase AAA_17 PF13207.1 EFX02174.1 - 0.00061 20.6 0.0 2.1 9.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EFX02174.1 - 0.00079 19.3 0.0 0.043 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.20 EFX02174.1 - 0.0012 18.4 0.5 0.068 12.6 0.1 2.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_10 PF12846.2 EFX02174.1 - 0.0014 18.1 0.4 0.42 9.9 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain AAA_33 PF13671.1 EFX02174.1 - 0.0035 17.2 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EFX02174.1 - 0.0064 16.1 0.7 0.35 10.4 0.1 2.5 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.1 EFX02174.1 - 0.0068 16.7 0.1 0.71 10.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EFX02174.1 - 0.0077 16.3 0.0 6.3 7.0 0.0 3.2 3 0 0 3 3 3 0 RNA helicase AAA PF00004.24 EFX02174.1 - 0.0082 16.3 0.0 0.047 13.8 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 EFX02174.1 - 0.0082 16.0 2.5 3.6 7.5 0.2 3.0 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit T2SE PF00437.15 EFX02174.1 - 0.0083 15.0 0.0 0.38 9.6 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein Dynamin_N PF00350.18 EFX02174.1 - 0.0093 15.7 0.1 0.29 10.9 0.0 2.2 2 0 0 2 2 2 1 Dynamin family NB-ARC PF00931.17 EFX02174.1 - 0.01 14.7 0.4 0.54 9.0 0.1 2.7 2 1 0 2 2 2 0 NB-ARC domain AAA_18 PF13238.1 EFX02174.1 - 0.017 15.4 0.0 3.7 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.10 EFX02174.1 - 0.03 12.9 0.1 0.22 10.1 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_5 PF07728.9 EFX02174.1 - 0.044 13.5 0.1 1.3 8.7 0.0 3.1 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) MobB PF03205.9 EFX02174.1 - 0.088 12.5 3.9 5.4 6.7 0.1 2.9 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 EFX02174.1 - 0.095 12.1 1.3 3.1 7.2 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.13 EFX02174.1 - 0.13 11.7 0.3 7 6.0 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 EFX02174.1 - 0.15 11.8 4.8 0.74 9.6 0.1 3.6 3 0 0 3 3 3 0 Part of AAA domain Guanylate_kin PF00625.16 EFX02174.1 - 0.3 10.4 0.0 0.84 9.0 0.0 1.7 2 0 0 2 2 2 0 Guanylate kinase DIOX_N PF14226.1 EFX02175.1 - 7e-19 68.4 0.0 1.7e-18 67.2 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX02175.1 - 6.6e-16 58.4 0.0 1.1e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Aldolase_II PF00596.16 EFX02177.1 - 2e-42 144.8 0.0 2.6e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain SseB PF07179.7 EFX02177.1 - 0.17 11.7 0.0 0.33 10.7 0.0 1.5 1 1 0 1 1 1 0 SseB protein N-terminal domain MFS_1 PF07690.11 EFX02179.1 - 3.4e-48 164.1 55.0 7.3e-47 159.7 38.1 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX02179.1 - 1.6e-22 79.5 15.2 1.6e-22 79.5 10.5 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFX02179.1 - 5.1e-15 54.9 14.2 5.1e-15 54.9 9.8 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter Ank_2 PF12796.2 EFX02179.1 - 1.6e-07 31.5 0.1 1.5e-06 28.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EFX02179.1 - 0.0011 18.9 2.8 0.85 10.0 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 EFX02179.1 - 0.045 14.2 0.2 0.41 11.2 0.2 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX02179.1 - 0.07 13.4 2.7 5.5 7.3 0.0 3.7 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.25 EFX02179.1 - 0.52 10.2 7.6 2.3 8.2 0.1 3.8 4 0 0 4 4 4 0 Ankyrin repeat DUF1768 PF08719.6 EFX02180.1 - 2.1e-45 154.2 0.0 2.4e-45 154.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) LMWPc PF01451.16 EFX02181.1 - 5.3e-34 117.4 0.0 6e-34 117.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase DUF566 PF04484.7 EFX02182.1 - 9.7 5.5 10.8 23 4.3 6.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF566) Ytp1 PF10355.4 EFX02184.1 - 2.5e-81 272.8 17.1 2.5e-81 272.8 11.9 1.8 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EFX02184.1 - 1.2e-34 117.9 3.1 1.2e-34 117.9 2.1 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) DUF3180 PF11377.3 EFX02184.1 - 2.8 7.7 15.9 0.12 12.1 4.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) UbiA PF01040.13 EFX02185.1 - 2.3e-33 115.5 18.5 2.3e-33 115.5 12.8 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF3040 PF11239.3 EFX02185.1 - 0.19 11.8 1.2 0.62 10.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Aminotran_5 PF00266.14 EFX02186.1 - 1.7e-26 92.8 0.0 7.6e-17 61.1 0.0 3.1 3 0 0 3 3 3 3 Aminotransferase class-V DUF442 PF04273.8 EFX02186.1 - 0.14 12.0 0.9 6.2 6.7 0.2 2.5 2 0 0 2 2 2 0 Putative phosphatase (DUF442) Phosphoesterase PF04185.9 EFX02187.1 - 3.7e-78 263.3 2.3 3.7e-78 263.3 1.6 1.7 2 0 0 2 2 2 1 Phosphoesterase family Fascin PF06268.8 EFX02187.1 - 0.0058 16.7 0.5 0.026 14.6 0.3 2.2 1 1 0 1 1 1 1 Fascin domain PAS_11 PF14598.1 EFX02187.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 PAS domain DEAD PF00270.24 EFX02189.1 - 1.4e-18 66.9 0.0 4e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EFX02189.1 - 2.2e-11 43.9 2.2 7.5e-10 38.9 0.0 3.8 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFX02189.1 - 1.8e-07 30.8 0.1 5.9e-07 29.2 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.11 EFX02189.1 - 0.0092 15.2 0.0 0.021 14.0 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein Vps16_N PF04841.8 EFX02190.1 - 1.2e-96 323.7 0.0 1.5e-96 323.4 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.7 EFX02190.1 - 2.8e-74 249.9 0.0 4.1e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region NUC205 PF08168.6 EFX02191.1 - 0.1 12.0 0.1 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 NUC205 domain Oxysterol_BP PF01237.13 EFX02192.1 - 1.6e-123 411.6 0.4 5.5e-123 409.9 0.0 2.0 3 0 0 3 3 3 1 Oxysterol-binding protein Ank_2 PF12796.2 EFX02192.1 - 5.3e-18 65.1 0.4 4.8e-12 46.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFX02192.1 - 8.1e-18 64.0 4.3 4.7e-10 39.3 0.7 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX02192.1 - 9e-16 57.9 0.3 3.3e-09 36.9 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 EFX02192.1 - 1.2e-15 56.3 3.1 3.5e-06 26.5 0.3 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 EFX02192.1 - 2.9e-12 45.5 1.3 0.00028 20.8 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat PH PF00169.24 EFX02192.1 - 1.9e-11 44.0 0.3 3.7e-11 43.1 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 EFX02192.1 - 7.3e-08 32.3 1.0 1.9e-07 31.0 0.7 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain FMO-like PF00743.14 EFX02193.1 - 2.1e-39 135.1 0.1 5.6e-21 74.3 0.1 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EFX02193.1 - 1.5e-20 74.0 1.5 3.3e-19 69.7 1.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX02193.1 - 2.1e-11 43.8 1.3 4.2e-09 36.3 0.6 2.9 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.19 EFX02193.1 - 2.2e-11 43.2 1.2 4e-07 29.2 0.1 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX02193.1 - 1.5e-10 41.3 0.0 2.1e-09 37.5 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX02193.1 - 4.4e-08 32.4 5.4 4.1e-06 25.9 0.1 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFX02193.1 - 4.6e-07 29.7 0.1 1.3e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFX02193.1 - 2.5e-06 27.8 3.8 0.00045 20.5 1.1 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX02193.1 - 0.00052 19.1 0.5 0.00091 18.3 0.4 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.2 EFX02193.1 - 0.00056 19.1 0.1 0.0046 16.0 0.0 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase IlvN PF07991.7 EFX02193.1 - 0.0013 18.1 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain HI0933_like PF03486.9 EFX02193.1 - 0.0032 16.0 3.0 0.017 13.6 0.5 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_2 PF03446.10 EFX02193.1 - 0.0049 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EFX02193.1 - 0.0049 16.5 0.9 0.0093 15.6 0.6 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.19 EFX02193.1 - 0.02 13.9 4.0 0.045 12.8 0.2 2.5 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.19 EFX02193.1 - 0.022 13.5 1.0 0.035 12.9 0.7 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.14 EFX02193.1 - 0.055 12.5 1.3 0.12 11.4 0.3 1.8 2 0 0 2 2 2 0 FAD binding domain NAD_binding_10 PF13460.1 EFX02193.1 - 0.096 12.6 2.4 0.14 12.1 0.7 1.9 2 0 0 2 2 2 0 NADH(P)-binding Shikimate_DH PF01488.15 EFX02193.1 - 0.13 12.3 0.7 0.41 10.7 0.1 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.17 EFX02193.1 - 0.2 10.4 0.3 0.36 9.6 0.2 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A MFS_1 PF07690.11 EFX02194.1 - 8.8e-06 24.6 22.3 0.0004 19.2 0.8 3.1 2 2 1 3 3 3 2 Major Facilitator Superfamily TctB PF07331.6 EFX02194.1 - 0.0049 16.5 2.0 0.014 15.0 1.2 1.9 1 1 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family DUF4017 PF13209.1 EFX02194.1 - 0.063 13.0 2.6 0.53 10.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) SIR2 PF02146.12 EFX02195.1 - 1.4e-31 109.6 0.0 2.9e-10 40.1 0.0 3.3 2 1 1 3 3 3 3 Sir2 family WSC PF01822.14 EFX02197.1 - 1.5e-109 358.0 99.1 1.8e-19 69.4 8.6 7.2 6 0 0 6 6 6 6 WSC domain NETI PF14044.1 EFX02197.1 - 0.0018 17.7 1.2 14 5.2 0.0 5.0 6 0 0 6 6 6 1 NETI protein PQQ_3 PF13570.1 EFX02197.1 - 2.3 8.5 18.5 0.19 12.0 0.1 6.0 6 0 0 6 6 6 0 PQQ-like domain Flg_new PF09479.5 EFX02197.1 - 3.4 7.7 12.4 21 5.2 0.0 5.9 6 0 0 6 6 6 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) Mannosyl_trans PF05007.8 EFX02198.1 - 4.7e-69 232.9 1.0 4.7e-69 232.9 0.7 1.5 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) Fmp27 PF10344.4 EFX02199.1 - 1.7e-207 691.0 0.0 3.5e-207 690.0 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Apt1 PF10351.4 EFX02199.1 - 5.6e-162 539.7 0.0 2e-161 537.9 0.0 2.0 1 1 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.4 EFX02199.1 - 3.1e-139 464.4 0.0 6.9e-139 463.3 0.0 1.6 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.4 EFX02199.1 - 5.7e-51 172.5 0.0 1.1e-50 171.5 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 EFX02199.1 - 3.7e-50 169.7 0.1 7.8e-50 168.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 EFX02199.1 - 4e-29 101.0 0.0 1.8e-28 98.9 0.0 2.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain ODC_AZ PF02100.12 EFX02200.1 - 6.8e-27 93.1 0.0 1.4e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme CPSase_L_D2 PF02786.12 EFX02201.1 - 1.8e-69 233.2 0.0 3e-69 232.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 EFX02201.1 - 6.8e-35 119.2 0.0 1.6e-34 118.0 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain CPSase_L_chain PF00289.17 EFX02201.1 - 3.2e-32 110.8 0.0 7.2e-32 109.7 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 EFX02201.1 - 7.9e-17 61.5 0.0 1.9e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 EFX02201.1 - 1.5e-15 56.5 0.7 4.4e-15 55.0 0.5 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 EFX02201.1 - 7.1e-13 48.0 0.0 1.2e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EFX02201.1 - 5e-07 29.3 0.0 1.2e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EFX02201.1 - 5.1e-06 25.9 0.0 1.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 EFX02201.1 - 1.9e-05 24.2 0.0 0.016 14.8 0.0 2.8 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD PF00529.15 EFX02201.1 - 0.0056 16.0 2.4 0.025 13.9 0.0 3.0 2 1 1 3 3 3 1 HlyD family secretion protein ATP-grasp_3 PF02655.9 EFX02201.1 - 0.0087 15.9 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.1 EFX02201.1 - 0.009 16.3 0.0 1.2 9.5 0.0 2.8 2 0 0 2 2 2 1 HlyD family secretion protein RimK PF08443.6 EFX02201.1 - 0.089 12.2 0.0 0.3 10.5 0.0 1.8 2 0 0 2 2 2 0 RimK-like ATP-grasp domain HlyD_2 PF12700.2 EFX02201.1 - 0.21 10.7 0.1 0.36 9.9 0.0 1.4 1 0 0 1 1 1 0 HlyD family secretion protein Glyco_hydro_3 PF00933.16 EFX02203.1 - 2.1e-74 250.2 0.0 3.1e-74 249.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX02203.1 - 3.2e-57 193.6 0.0 6.9e-57 192.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX02203.1 - 4.1e-16 58.6 0.0 7.9e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EFX02203.1 - 1e-05 25.1 0.0 1.9e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 PA14 domain SQS_PSY PF00494.14 EFX02204.1 - 7.9e-42 143.3 0.0 2.6e-41 141.7 0.0 1.7 2 0 0 2 2 2 1 Squalene/phytoene synthase TFIIF_alpha PF05793.7 EFX02205.1 - 0.1 10.9 2.0 0.13 10.6 1.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PIG-S PF10510.4 EFX02206.1 - 3.2e-144 481.4 0.0 3.8e-144 481.1 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Cache_2 PF08269.6 EFX02206.1 - 0.6 10.1 4.0 0.3 11.0 0.5 2.1 2 0 0 2 2 2 0 Cache domain DUF998 PF06197.8 EFX02208.1 - 1.6 8.0 14.7 1.9 7.7 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Cofilin_ADF PF00241.15 EFX02209.1 - 5.6e-11 42.4 0.0 6.5e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S9 PF00380.14 EFX02210.1 - 1.9e-38 131.4 0.1 2.2e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 TFR_dimer PF04253.10 EFX02211.1 - 9.4e-24 83.3 0.0 1.5e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 EFX02211.1 - 7.8e-13 48.5 0.0 1.4e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFX02211.1 - 2e-06 27.3 0.0 6e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 PA domain FAD_binding_3 PF01494.14 EFX02212.1 - 1.7e-13 50.3 0.5 5.1e-13 48.8 0.3 1.8 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 EFX02212.1 - 1.7e-05 23.9 0.2 0.00022 20.2 0.1 2.3 1 1 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 EFX02212.1 - 2.1e-05 23.5 0.2 0.00011 21.2 0.0 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFX02212.1 - 0.00013 21.7 0.7 0.048 13.4 0.0 2.8 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFX02212.1 - 0.00025 20.9 0.0 0.003 17.4 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX02212.1 - 0.0003 20.7 0.0 0.00088 19.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX02212.1 - 0.00086 18.2 0.1 0.0014 17.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 EFX02212.1 - 0.0013 18.7 0.1 0.022 14.8 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX02212.1 - 0.0036 15.8 0.1 0.011 14.2 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.22 EFX02212.1 - 0.012 16.0 0.0 0.069 13.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 EFX02212.1 - 0.012 14.4 0.0 0.044 12.6 0.0 1.7 2 0 0 2 2 2 0 Squalene epoxidase Aldo_ket_red PF00248.16 EFX02213.1 - 6.4e-76 254.8 0.0 7.3e-76 254.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HAD_2 PF13419.1 EFX02213.1 - 0.053 13.7 0.0 0.16 12.2 0.0 1.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Abhydrolase_2 PF02230.11 EFX02214.1 - 1.6e-61 207.4 0.0 1.8e-61 207.3 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 EFX02214.1 - 4.9e-16 58.7 0.4 2.7e-15 56.3 0.3 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX02214.1 - 1.6e-14 54.3 4.7 5.1e-10 39.6 1.3 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX02214.1 - 4.9e-08 32.4 0.5 1e-05 24.8 0.0 2.6 2 1 1 3 3 3 2 Prolyl oligopeptidase family FSH1 PF03959.8 EFX02214.1 - 1.9e-06 27.5 0.0 2.3e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.8 EFX02214.1 - 7.4e-06 25.6 0.0 0.0074 15.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 EFX02214.1 - 2.7e-05 23.8 0.0 0.0039 16.7 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.13 EFX02214.1 - 0.00011 21.5 0.0 0.00017 20.9 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.15 EFX02214.1 - 0.002 17.5 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DUF2974 PF11187.3 EFX02214.1 - 0.0042 16.4 0.1 0.011 15.1 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2974) Lipase_3 PF01764.20 EFX02214.1 - 0.0072 15.9 0.0 0.032 13.8 0.0 1.8 1 1 1 2 2 2 1 Lipase (class 3) Cutinase PF01083.17 EFX02214.1 - 0.019 14.7 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 Cutinase AXE1 PF05448.7 EFX02214.1 - 0.027 12.9 0.1 0.044 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_4 PF08386.5 EFX02214.1 - 0.11 12.3 0.0 0.32 10.8 0.0 1.7 2 0 0 2 2 2 0 TAP-like protein Gly_transf_sug PF04488.10 EFX02215.1 - 1.5e-13 50.9 0.0 3e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Methyltransf_23 PF13489.1 EFX02216.1 - 5.8e-17 61.8 0.0 1e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02216.1 - 9.1e-07 29.4 0.0 4e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02216.1 - 9.5e-07 28.5 0.0 2.4e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02216.1 - 1.5e-06 28.6 0.0 3.7e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02216.1 - 0.00024 21.5 0.0 0.00048 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX02216.1 - 0.0022 18.2 0.0 0.0046 17.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX02216.1 - 0.0026 17.1 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 EFX02216.1 - 0.0028 16.7 0.0 0.0048 15.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 EFX02216.1 - 0.0041 16.3 0.0 0.0066 15.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EFX02216.1 - 0.039 14.0 0.0 0.05 13.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 EFX02216.1 - 0.043 13.3 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.13 EFX02216.1 - 0.044 12.8 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 EFX02216.1 - 0.05 13.0 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase RRM_1 PF00076.17 EFX02217.1 - 2.6e-12 46.2 0.0 6.1e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX02217.1 - 5.1e-10 39.1 0.0 9.2e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX02217.1 - 9.7e-05 22.1 0.0 0.00021 21.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Asp-B-Hydro_N PF05279.6 EFX02217.1 - 3.9 7.2 28.8 6.4 6.5 19.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Mitofilin PF09731.4 EFX02217.1 - 7.1 5.1 32.8 10 4.6 22.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TauD PF02668.11 EFX02219.1 - 6.8e-29 101.3 0.0 8.8e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TPR_12 PF13424.1 EFX02220.1 - 1.1 9.2 9.7 2.8 7.9 0.5 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat S1-P1_nuclease PF02265.11 EFX02221.1 - 2.5e-70 236.9 0.0 2.9e-70 236.7 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease 4HBT PF03061.17 EFX02222.1 - 2e-17 63.1 0.3 3.3e-17 62.3 0.2 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 EFX02222.1 - 7.4e-05 22.6 0.2 8.5e-05 22.4 0.2 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily MaoC_dehydratas PF01575.14 EFX02222.1 - 0.12 11.7 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 MaoC like domain DUF202 PF02656.10 EFX02223.1 - 0.17 12.1 3.6 0.34 11.1 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Dicty_CAR PF05462.6 EFX02224.1 - 1.9e-07 30.2 2.4 1.9e-07 30.2 1.7 2.0 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor Git3 PF11710.3 EFX02224.1 - 0.00084 18.9 2.9 0.00084 18.9 2.0 1.7 1 1 1 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.4 EFX02224.1 - 0.0029 16.7 8.6 0.0042 16.2 6.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_2 PF00002.19 EFX02224.1 - 0.056 12.5 3.6 0.032 13.3 0.9 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.16 EFX02224.1 - 0.06 12.4 6.2 0.045 12.8 2.2 2.0 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF2254 PF10011.4 EFX02224.1 - 0.2 10.0 1.3 0.23 9.8 0.1 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) DUF2842 PF11003.3 EFX02224.1 - 0.62 9.9 7.3 4.6 7.1 0.4 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) ABC2_membrane_5 PF13346.1 EFX02224.1 - 4.2 6.6 15.6 0.92 8.7 1.3 3.1 3 0 0 3 3 3 0 ABC-2 family transporter protein MAP65_ASE1 PF03999.7 EFX02226.1 - 2.7e-64 217.8 20.3 6.8e-64 216.5 14.1 1.5 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Ank_2 PF12796.2 EFX02227.1 - 1.8e-142 464.0 60.7 6e-21 74.5 1.3 9.9 3 2 9 12 12 12 11 Ankyrin repeats (3 copies) Ank PF00023.25 EFX02227.1 - 8.1e-114 366.2 79.2 1.2e-08 34.2 0.1 17.6 17 0 0 17 17 17 16 Ankyrin repeat Ank_4 PF13637.1 EFX02227.1 - 2.3e-83 273.2 39.7 1.6e-09 38.0 0.2 11.8 4 2 10 14 14 14 14 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX02227.1 - 2.1e-80 256.5 38.4 3.6e-06 26.6 0.0 17.7 17 0 0 17 17 17 16 Ankyrin repeat Ank_5 PF13857.1 EFX02227.1 - 2.9e-74 243.4 60.1 7e-10 38.8 0.8 15.8 4 3 11 15 15 15 15 Ankyrin repeats (many copies) HET PF06985.6 EFX02227.1 - 2.6e-47 160.4 0.0 3.8e-25 88.6 0.0 3.0 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) EST1_DNA_bind PF10373.4 EFX02228.1 - 1.6e-14 53.7 0.0 2.9e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Fungal_trans PF04082.13 EFX02229.1 - 7.5e-28 97.1 0.1 1.3e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02229.1 - 3.7e-09 36.3 5.0 7.4e-09 35.3 3.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 EFX02230.1 - 0.0042 16.9 3.0 0.0077 16.1 2.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YscO PF07321.7 EFX02230.1 - 0.12 12.2 0.7 0.19 11.5 0.5 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO XPA_N PF01286.13 EFX02230.1 - 0.23 11.1 2.1 0.97 9.1 0.5 2.3 2 0 0 2 2 2 0 XPA protein N-terminal Meth_synt_2 PF01717.13 EFX02231.1 - 5.3e-15 55.2 0.0 6.8e-14 51.5 0.0 2.1 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 EFX02231.1 - 0.00018 20.8 0.0 0.022 14.0 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain Trp_oprn_chp PF09534.5 EFX02232.1 - 0.012 15.1 0.2 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Syndecan PF01034.15 EFX02232.1 - 0.014 15.0 0.2 0.014 15.0 0.1 2.0 3 0 0 3 3 3 0 Syndecan domain DUF456 PF04306.8 EFX02232.1 - 0.078 13.0 0.1 0.078 13.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF456) Podoplanin PF05808.6 EFX02232.1 - 0.55 9.7 4.9 0.077 12.5 0.4 1.7 2 0 0 2 2 2 0 Podoplanin Gly-zipper_OmpA PF13436.1 EFX02232.1 - 0.91 9.1 5.1 1.9 8.1 3.5 1.7 1 1 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Dmrt1 PF12374.3 EFX02232.1 - 4.5 7.6 8.3 1.9 8.9 3.6 2.0 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 Thiolase_N PF00108.18 EFX02233.1 - 1.2e-70 237.4 0.0 1.9e-70 236.9 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFX02233.1 - 1.8e-42 143.6 0.2 1.8e-42 143.6 0.1 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.5 EFX02233.1 - 0.0074 15.9 0.4 0.45 10.2 0.0 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.5 EFX02233.1 - 0.017 15.1 0.1 0.061 13.3 0.1 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Ribosomal_L50 PF10501.4 EFX02234.1 - 7.6e-20 70.9 0.0 1.2e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal subunit 39S RTC PF01137.16 EFX02235.1 - 7e-42 142.7 0.1 1.6e-41 141.5 0.1 1.6 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase Semialdhyde_dh PF01118.19 EFX02235.1 - 9.9e-27 93.6 0.2 4.2e-26 91.6 0.0 2.3 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DUF619 PF04768.8 EFX02235.1 - 6.1e-25 87.5 0.1 1.2e-24 86.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF619) TFIIB PF00382.14 EFX02236.1 - 1.6e-30 104.6 1.3 6.6e-18 64.2 0.1 2.8 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 EFX02236.1 - 2.9e-21 75.4 0.5 2.9e-21 75.4 0.3 3.0 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.18 EFX02236.1 - 5.1e-07 29.3 1.5 0.028 13.9 0.1 2.4 1 1 0 2 2 2 2 Cyclin, N-terminal domain Beta-lactamase PF00144.19 EFX02237.1 - 4.8e-53 180.3 0.0 6.8e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.15 EFX02237.1 - 0.00016 21.0 0.0 0.0017 17.6 0.0 2.2 2 0 0 2 2 2 1 D-alanyl-D-alanine carboxypeptidase Tachylectin PF14517.1 EFX02237.1 - 0.071 12.4 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Tachylectin ABC_membrane PF00664.18 EFX02238.1 - 3.2e-60 203.8 18.0 1.4e-29 103.4 9.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFX02238.1 - 5.5e-56 188.6 0.0 1.6e-27 96.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFX02238.1 - 5.1e-14 52.9 0.0 0.00031 20.8 0.0 4.1 4 0 0 4 4 4 3 AAA domain SMC_N PF02463.14 EFX02238.1 - 1.1e-11 44.4 0.2 0.13 11.4 0.0 4.3 3 1 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EFX02238.1 - 4.6e-09 35.6 0.1 0.0041 16.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 EFX02238.1 - 4.2e-08 34.0 0.0 0.01 16.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX02238.1 - 8.8e-07 29.0 3.4 0.039 13.9 0.2 3.3 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 EFX02238.1 - 2.2e-06 27.8 0.2 0.3 11.2 0.0 3.9 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EFX02238.1 - 4.1e-06 27.1 0.0 0.038 14.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EFX02238.1 - 7.3e-06 25.6 0.2 0.36 10.2 0.0 3.7 4 0 0 4 4 3 2 AAA-like domain SbcCD_C PF13558.1 EFX02238.1 - 1.4e-05 24.9 2.1 0.15 11.9 0.1 3.9 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 EFX02238.1 - 1.8e-05 24.2 0.0 0.092 12.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 EFX02238.1 - 2.3e-05 23.6 0.0 0.19 10.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.12 EFX02238.1 - 2.3e-05 24.3 0.6 0.021 14.6 0.1 2.6 3 0 0 3 3 2 2 Domain of unknown function DUF87 MobB PF03205.9 EFX02238.1 - 0.00014 21.5 0.0 0.29 10.8 0.0 3.0 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 EFX02238.1 - 0.00016 21.3 0.0 0.72 9.3 0.0 3.4 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.1 EFX02238.1 - 0.00089 19.1 0.0 2.2 8.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.13 EFX02238.1 - 0.001 18.6 0.6 0.19 11.1 0.1 2.9 2 1 1 3 3 3 1 FtsK/SpoIIIE family AAA_23 PF13476.1 EFX02238.1 - 0.0012 19.2 0.0 1 9.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFX02238.1 - 0.0012 18.6 0.0 3 7.7 0.0 3.9 4 0 0 4 4 4 1 AAA domain NACHT PF05729.7 EFX02238.1 - 0.0015 18.1 0.4 0.97 9.0 0.0 3.3 3 0 0 3 3 3 1 NACHT domain MMR_HSR1 PF01926.18 EFX02238.1 - 0.002 18.0 0.1 0.81 9.6 0.0 2.9 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_5 PF07728.9 EFX02238.1 - 0.0039 16.9 0.0 7.8 6.2 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 EFX02238.1 - 0.0066 15.3 0.0 2.2 7.0 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_15 PF13175.1 EFX02238.1 - 0.0078 15.3 0.0 0.71 8.8 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain DUF3987 PF13148.1 EFX02238.1 - 0.0082 14.7 0.0 0.95 7.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) T2SE PF00437.15 EFX02238.1 - 0.0083 15.0 0.0 0.62 8.9 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_13 PF13166.1 EFX02238.1 - 0.015 13.8 0.0 5.6 5.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain Miro PF08477.8 EFX02238.1 - 0.026 15.0 0.0 2.4 8.6 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein APS_kinase PF01583.15 EFX02238.1 - 0.027 14.1 1.1 6.6 6.3 0.0 3.2 4 0 0 4 4 3 0 Adenylylsulphate kinase Zeta_toxin PF06414.7 EFX02238.1 - 0.035 13.1 0.0 6.4 5.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.12 EFX02238.1 - 0.086 12.3 0.1 6.9 6.1 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.17 EFX02238.1 - 0.11 12.6 0.0 16 5.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.10 EFX02238.1 - 0.13 12.0 0.0 6.4 6.4 0.0 2.9 4 0 0 4 4 3 0 NTPase Dynamin_N PF00350.18 EFX02238.1 - 0.29 10.9 0.8 22 4.8 0.3 2.5 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.15 EFX02238.1 - 0.54 8.8 0.0 7.1 5.2 0.1 2.0 2 0 0 2 2 2 0 G-protein alpha subunit DUF3584 PF12128.3 EFX02238.1 - 0.72 7.1 0.0 1.2 6.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sugar_tr PF00083.19 EFX02239.1 - 9.7e-87 291.3 22.6 1.2e-86 291.1 15.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX02239.1 - 3.7e-24 85.1 58.7 1.2e-22 80.0 20.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC2_membrane_2 PF12679.2 EFX02239.1 - 2.5 6.8 11.4 2.5 6.8 6.7 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein SNF2_N PF00176.18 EFX02240.1 - 2.7e-72 243.1 3.2 5.7e-72 242.0 2.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.1 EFX02240.1 - 2.9e-51 173.1 20.0 2.9e-51 173.1 13.9 4.1 4 0 0 4 4 4 1 DNA-binding domain Helicase_C PF00271.26 EFX02240.1 - 6.3e-16 58.0 0.0 2.3e-15 56.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ADH_N PF08240.7 EFX02241.1 - 4e-26 90.9 2.7 6.5e-26 90.2 1.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX02241.1 - 3.5e-14 52.4 0.5 7.6e-14 51.3 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFX02241.1 - 1.7e-05 24.0 0.1 2.9e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pkinase PF00069.20 EFX02242.1 - 1.3e-71 240.8 0.0 1.6e-71 240.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02242.1 - 3.2e-31 108.3 0.0 4.9e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2075 PF09848.4 EFX02242.1 - 0.024 13.6 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) APH PF01636.18 EFX02242.1 - 0.024 14.3 1.0 0.069 12.8 0.1 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 EFX02242.1 - 0.097 11.7 0.0 0.29 10.1 0.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family A_deaminase PF00962.17 EFX02243.1 - 8.8e-30 103.7 0.0 1.1e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF500 PF04366.7 EFX02245.1 - 1.3e-41 140.9 0.1 2e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) Phosducin PF02114.11 EFX02246.1 - 1.9e-16 59.6 0.0 3e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Phosducin Sdh_cyt PF01127.17 EFX02247.1 - 2.2e-17 63.0 3.1 3.9e-17 62.2 2.1 1.4 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Daxx PF03344.10 EFX02247.1 - 0.19 10.1 3.4 0.28 9.6 2.4 1.1 1 0 0 1 1 1 0 Daxx Family NmrA PF05368.8 EFX02248.1 - 2.3e-12 46.6 0.0 3.3e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX02248.1 - 2.8e-12 46.9 0.2 6.9e-12 45.7 0.1 1.7 2 0 0 2 2 2 1 NADH(P)-binding Saccharop_dh PF03435.13 EFX02248.1 - 4.7e-06 25.8 0.0 6.1e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 EFX02248.1 - 0.0025 17.2 0.3 0.005 16.2 0.1 1.6 1 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 EFX02248.1 - 0.034 14.0 0.1 0.24 11.3 0.0 2.3 2 0 0 2 2 2 0 short chain dehydrogenase Semialdhyde_dh PF01118.19 EFX02248.1 - 0.044 14.0 0.1 0.086 13.1 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFX02248.1 - 0.046 13.8 0.0 0.085 12.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.15 EFX02248.1 - 0.058 13.3 0.2 0.12 12.2 0.1 1.6 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 EFX02248.1 - 0.09 11.6 0.1 0.15 10.9 0.1 1.4 1 0 0 1 1 1 0 Male sterility protein 3Beta_HSD PF01073.14 EFX02248.1 - 0.12 11.0 0.0 0.18 10.4 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox_3 PF13738.1 EFX02249.1 - 1.1e-20 74.5 0.0 1e-19 71.3 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX02249.1 - 3.8e-11 42.5 0.0 3.3e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.14 EFX02249.1 - 7.1e-09 34.4 0.0 5.1e-08 31.5 0.0 1.9 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFX02249.1 - 2.4e-07 30.8 0.0 3e-07 30.5 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX02249.1 - 1.2e-05 25.1 0.2 0.014 15.1 0.1 3.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFX02249.1 - 0.0002 21.3 0.0 0.00058 19.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX02249.1 - 0.0013 17.6 0.7 1.6 7.5 0.0 3.4 4 0 0 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.12 EFX02249.1 - 0.007 15.4 0.0 0.11 11.5 0.0 2.5 3 0 0 3 3 3 1 Thi4 family Pyr_redox PF00070.22 EFX02249.1 - 0.19 12.1 0.2 2.8 8.4 0.0 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 EFX02250.1 - 9.3e-35 119.4 0.4 2.1e-34 118.2 0.3 1.6 1 0 0 1 1 1 1 ThiF family Glyco_hydro_17 PF00332.13 EFX02250.1 - 0.012 14.6 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 Ldh_1_N PF00056.18 EFX02250.1 - 0.014 15.2 0.2 0.027 14.3 0.2 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain ApbA PF02558.11 EFX02250.1 - 0.037 13.4 0.1 0.074 12.4 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 EFX02250.1 - 0.058 13.0 0.3 0.058 13.0 0.2 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1049 PF06305.6 EFX02250.1 - 0.098 12.1 0.2 0.26 10.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Saccharop_dh PF03435.13 EFX02250.1 - 0.3 9.9 2.8 0.8 8.6 1.0 2.4 2 1 0 2 2 2 0 Saccharopine dehydrogenase Peptidase_S24 PF00717.18 EFX02252.1 - 2.9e-07 30.0 0.0 4.8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like NmrA PF05368.8 EFX02253.1 - 2.2e-38 131.7 0.0 2.8e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX02253.1 - 1e-10 41.9 0.1 1.5e-10 41.4 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX02253.1 - 5.6e-06 25.2 0.0 7.7e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFX02253.1 - 0.0014 18.0 0.2 0.0021 17.5 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 EFX02253.1 - 0.0094 15.9 0.2 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.10 EFX02253.1 - 0.039 12.8 0.1 0.058 12.2 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Peptidase_S66 PF02016.10 EFX02254.1 - 4.7e-52 176.6 0.0 5.5e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 LD-carboxypeptidase adh_short PF00106.20 EFX02255.1 - 2.2e-25 89.4 4.8 6.8e-25 87.9 3.3 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX02255.1 - 1.2e-13 51.1 0.7 1.8e-13 50.5 0.5 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFX02255.1 - 0.00085 19.3 0.3 0.0024 17.8 0.2 1.8 1 1 0 1 1 1 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 EFX02255.1 - 0.12 12.2 2.0 0.21 11.4 0.5 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF3203 PF11462.3 EFX02255.1 - 0.21 11.5 1.3 0.42 10.5 0.1 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3203) Semialdhyde_dhC PF02774.13 EFX02256.1 - 8.2e-37 126.8 0.0 1.1e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 EFX02256.1 - 1.6e-28 99.4 0.0 2.9e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EFX02256.1 - 0.009 15.9 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus DXP_reductoisom PF02670.11 EFX02256.1 - 0.031 14.8 0.0 0.073 13.6 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase TOM13 PF08219.6 EFX02257.1 - 2.9e-31 107.0 0.0 3.5e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 FAD_binding_7 PF03441.9 EFX02259.1 - 6.6e-53 179.7 0.1 1.4e-52 178.6 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 EFX02259.1 - 1.6e-14 53.9 0.0 3.1e-13 49.7 0.0 2.4 2 0 0 2 2 2 1 DNA photolyase DUF4044 PF13253.1 EFX02260.1 - 1.2 8.3 5.7 0.31 10.2 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) TP_methylase PF00590.15 EFX02262.1 - 3.3e-41 141.3 2.3 6.5e-41 140.3 1.6 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.1 EFX02262.1 - 5.4e-08 33.0 0.0 1.2e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 EFX02262.1 - 4.5e-07 29.0 0.3 4.9e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 EFX02262.1 - 5.8e-07 28.3 0.0 1.3e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Alk_phosphatase PF00245.15 EFX02263.1 - 4.4e-106 355.1 0.0 5.6e-106 354.7 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 EFX02263.1 - 7.5e-05 22.2 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily RmlD_sub_bind PF04321.12 EFX02264.1 - 4.6e-15 55.2 0.0 1e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 EFX02264.1 - 5e-14 52.2 0.0 1.3e-13 50.9 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFX02264.1 - 3.9e-05 22.6 0.0 6.8e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EFX02264.1 - 0.0011 18.9 0.0 0.0028 17.5 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase Macro PF01661.16 EFX02264.1 - 0.0037 17.1 0.2 0.02 14.8 0.0 2.2 2 0 0 2 2 2 1 Macro domain 3Beta_HSD PF01073.14 EFX02264.1 - 0.0037 15.9 0.0 0.013 14.1 0.0 1.7 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFX02264.1 - 0.028 13.3 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein KR PF08659.5 EFX02264.1 - 0.087 12.4 0.0 0.54 9.8 0.0 2.2 2 0 0 2 2 2 0 KR domain ATG16 PF08614.6 EFX02265.1 - 3.8e-47 160.6 19.0 4.4e-47 160.4 13.2 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.1 EFX02265.1 - 0.0013 18.2 8.4 0.0013 18.2 5.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) GAS PF13851.1 EFX02265.1 - 0.17 11.0 12.8 0.072 12.2 2.8 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4140 PF13600.1 EFX02265.1 - 0.2 12.1 11.9 2.7 8.4 0.1 2.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) TSC22 PF01166.13 EFX02265.1 - 1 9.3 0.0 1 9.3 0.0 2.9 2 1 0 2 2 2 0 TSC-22/dip/bun family DivIC PF04977.10 EFX02265.1 - 2.5 7.6 12.8 4.1 6.9 0.0 3.2 3 0 0 3 3 3 0 Septum formation initiator APG6 PF04111.7 EFX02265.1 - 5.5 5.9 13.1 0.37 9.8 1.5 1.9 1 1 0 1 1 1 0 Autophagy protein Apg6 adh_short PF00106.20 EFX02267.1 - 5.4e-21 75.2 1.7 9.8e-12 45.1 0.3 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EFX02267.1 - 4.7e-11 42.6 0.3 0.0001 22.0 0.1 2.2 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.1 EFX02267.1 - 1.1e-05 25.2 0.1 0.00034 20.4 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 EFX02267.1 - 0.07 12.9 0.2 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Hydrolase_6 PF13344.1 EFX02268.1 - 4.5e-19 68.1 0.0 9.7e-19 67.1 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX02268.1 - 2.7e-15 55.8 0.2 3.5e-14 52.2 0.1 2.8 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 EFX02268.1 - 1.8e-06 28.5 0.0 0.018 15.4 0.0 4.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX02268.1 - 6.9e-05 23.1 0.4 0.019 15.1 0.0 3.9 3 2 1 4 4 4 1 Haloacid dehalogenase-like hydrolase Translin PF01997.11 EFX02269.1 - 1.5e-51 174.8 0.0 1.8e-51 174.6 0.0 1.1 1 0 0 1 1 1 1 Translin family DUF4237 PF14021.1 EFX02270.1 - 5.9e-31 106.5 0.2 1.1e-30 105.6 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4237) Peptidase_C65 PF10275.4 EFX02271.1 - 6.9e-43 146.7 0.0 6.9e-43 146.7 0.0 1.8 2 0 0 2 2 2 1 Peptidase C65 Otubain LpxC PF03331.8 EFX02271.1 - 0.73 8.7 1.6 1.2 8.0 1.1 1.2 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase SurE PF01975.12 EFX02272.1 - 1.5e-34 119.0 0.0 2.8e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 Survival protein SurE Abhydrolase_5 PF12695.2 EFX02272.1 - 0.0015 18.2 1.1 0.034 13.9 0.1 3.1 3 1 0 3 3 3 1 Alpha/beta hydrolase family Transp_cyt_pur PF02133.10 EFX02273.1 - 1.5e-92 310.4 34.7 1.8e-92 310.2 24.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PQ-loop PF04193.9 EFX02274.1 - 4.4e-40 135.0 7.8 1.8e-20 72.2 0.2 2.7 2 0 0 2 2 2 2 PQ loop repeat Curto_V3 PF07436.6 EFX02274.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Curtovirus V3 protein BAR PF03114.13 EFX02275.1 - 2.7e-52 177.5 1.4 3.3e-52 177.2 1.0 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.4 EFX02275.1 - 2.8e-06 26.4 2.2 4.1e-06 25.9 1.6 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking APG6 PF04111.7 EFX02275.1 - 0.083 11.9 3.9 0.12 11.3 2.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 EFX02275.1 - 0.11 12.0 4.6 0.2 11.2 3.2 1.3 1 0 0 1 1 1 0 IncA protein GBP_C PF02841.9 EFX02275.1 - 1.1 8.4 10.2 0.085 12.0 3.9 1.4 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Arteri_GP4 PF02497.10 EFX02276.1 - 0.089 12.7 0.0 0.34 10.8 0.0 1.9 2 0 0 2 2 2 0 Arterivirus glycoprotein DUF2721 PF11026.3 EFX02276.1 - 0.69 9.5 3.3 0.79 9.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Aldo_ket_red PF00248.16 EFX02277.1 - 2.1e-46 158.0 0.0 2.4e-46 157.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family mRNA_triPase PF02940.10 EFX02278.1 - 7.7e-56 189.2 0.3 1.2e-55 188.5 0.2 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain dCMP_cyt_deam_1 PF00383.17 EFX02279.1 - 8.4e-11 41.4 0.1 1.1e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 EFX02279.1 - 0.0018 17.9 0.2 0.0023 17.5 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Bd3614-deam PF14439.1 EFX02279.1 - 0.018 14.8 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase Fungal_trans PF04082.13 EFX02280.1 - 5.3e-12 45.1 0.0 8.3e-12 44.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02280.1 - 1e-07 31.7 10.0 1.7e-07 30.9 6.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EF-1_beta_acid PF10587.4 EFX02280.1 - 2.7 8.1 5.3 5.8 7.1 3.7 1.5 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Paf67 PF10255.4 EFX02282.1 - 9.7e-153 508.8 0.5 1.1e-152 508.5 0.4 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 EFX02282.1 - 0.0066 16.2 0.0 0.033 14.0 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02282.1 - 0.02 14.4 0.0 0.082 12.5 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02282.1 - 0.034 14.0 1.6 0.36 10.7 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFX02282.1 - 0.17 11.5 1.2 0.81 9.3 0.1 2.3 2 0 0 2 2 2 0 TPR repeat NmrA PF05368.8 EFX02284.1 - 3e-25 88.8 0.0 3.9e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX02284.1 - 8.2e-08 32.4 1.8 1.8e-07 31.3 1.2 1.7 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX02284.1 - 0.00011 20.9 0.7 0.00016 20.4 0.5 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFX02284.1 - 0.00017 21.0 2.0 0.00022 20.7 0.2 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DXP_reductoisom PF02670.11 EFX02284.1 - 0.00074 20.0 0.1 0.0021 18.6 0.0 1.8 2 0 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Saccharop_dh PF03435.13 EFX02284.1 - 0.0014 17.6 0.7 0.0021 17.0 0.5 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 EFX02284.1 - 0.0014 18.8 0.1 0.0039 17.4 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.5 EFX02284.1 - 0.0033 17.1 0.1 0.0096 15.5 0.0 1.8 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 EFX02284.1 - 0.012 15.5 1.4 0.05 13.5 0.2 2.4 2 0 0 2 2 2 0 short chain dehydrogenase DapB_N PF01113.15 EFX02284.1 - 0.073 12.9 0.2 0.19 11.6 0.2 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 EFX02284.1 - 0.079 11.8 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein F420_oxidored PF03807.12 EFX02284.1 - 0.091 13.1 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PLU-1 PF08429.6 EFX02285.1 - 1.9e-89 299.9 5.7 2.9e-87 292.6 4.2 2.3 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.17 EFX02285.1 - 7.1e-43 145.4 0.2 1.4e-42 144.4 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.16 EFX02285.1 - 4.4e-23 80.9 0.3 1.3e-22 79.4 0.1 2.0 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain JmjN PF02375.12 EFX02285.1 - 3.1e-15 55.3 0.4 7.5e-15 54.1 0.3 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.11 EFX02285.1 - 6.5e-15 54.9 6.9 1.4e-14 53.8 4.8 1.6 1 0 0 1 1 1 1 C5HC2 zinc finger PHD PF00628.24 EFX02285.1 - 1.7e-08 34.0 16.2 2.5e-08 33.4 6.6 2.9 2 0 0 2 2 2 1 PHD-finger MannoseP_isomer PF01050.13 EFX02285.1 - 0.11 12.0 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Ribosomal_S7e PF01251.13 EFX02287.1 - 1e-82 276.2 0.1 1.1e-82 276.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e MFS_1 PF07690.11 EFX02288.1 - 6e-32 110.7 29.6 6e-32 110.7 20.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Ribosomal_L34e PF01199.13 EFX02290.1 - 1.3e-37 127.8 3.4 1.9e-37 127.3 2.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e DUF1428 PF07237.6 EFX02290.1 - 0.041 13.7 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) Zn_ribbon_recom PF13408.1 EFX02290.1 - 0.043 14.0 0.2 0.11 12.7 0.2 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain FhuF_C PF11575.3 EFX02290.1 - 1.5 8.5 4.2 24 4.7 0.1 2.9 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain Vint PF14623.1 EFX02291.1 - 6.3e-41 139.5 0.0 1e-40 138.8 0.0 1.3 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.1 EFX02291.1 - 9e-29 99.4 0.3 2e-28 98.2 0.0 1.8 2 0 0 2 2 2 1 VWA / Hh protein intein-like VWA_2 PF13519.1 EFX02291.1 - 2.9e-19 69.8 0.0 5.2e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EFX02291.1 - 9.6e-15 54.7 0.0 1.6e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 EFX02291.1 - 2.6e-08 33.6 0.0 1.2e-06 28.3 0.0 2.4 1 1 0 1 1 1 1 von Willebrand factor type A domain Hint_2 PF13403.1 EFX02291.1 - 0.037 13.9 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Hint domain Hint PF01079.15 EFX02291.1 - 0.039 13.1 0.0 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 Hint module Acetyltransf_1 PF00583.19 EFX02292.1 - 4e-06 26.7 0.0 6.8e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX02292.1 - 0.0014 18.7 0.0 0.0021 18.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ABA_GPCR PF12430.3 EFX02294.1 - 1e-49 168.3 0.0 2e-49 167.4 0.0 1.5 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 EFX02294.1 - 1.9e-18 66.2 0.2 7e-18 64.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3735) AdoHcyase PF05221.12 EFX02295.1 - 4.4e-138 458.6 0.1 5.1e-138 458.4 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 EFX02295.1 - 5.3e-83 276.7 1.8 7.9e-83 276.1 1.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 EFX02295.1 - 1.6e-05 24.1 0.1 3.3e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 EFX02295.1 - 0.003 16.9 0.2 0.0054 16.1 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TMEM107 PF14995.1 EFX02295.1 - 0.0077 16.3 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein ELFV_dehydrog PF00208.16 EFX02295.1 - 0.011 15.3 0.1 0.02 14.4 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ig PF00047.20 EFX02295.1 - 0.13 12.3 0.0 4.5 7.4 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain EAP30 PF04157.11 EFX02296.1 - 1.4e-65 220.6 0.0 1.6e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Oxidored_molyb PF00174.14 EFX02297.1 - 1e-50 171.4 0.0 1.4e-50 171.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 EFX02297.1 - 3.6e-26 91.3 0.6 8.7e-26 90.0 0.2 1.7 2 0 0 2 2 2 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.23 EFX02297.1 - 2.5e-09 36.7 0.1 5.3e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sel1 PF08238.7 EFX02298.1 - 4e-40 135.3 27.5 4e-06 27.2 0.0 8.1 7 0 0 7 7 7 7 Sel1 repeat ATP12 PF07542.6 EFX02298.1 - 1.8e-21 76.3 0.1 3.2e-21 75.5 0.1 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein WES_acyltransf PF03007.11 EFX02299.1 - 0.022 14.3 0.7 0.043 13.3 0.5 1.4 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain PCI PF01399.22 EFX02300.1 - 1e-16 61.1 0.0 2.5e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 EFX02300.1 - 0.00013 21.7 0.1 0.00029 20.6 0.1 1.5 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 TPR_7 PF13176.1 EFX02300.1 - 0.0012 18.5 1.6 0.23 11.3 0.1 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFX02300.1 - 0.0017 18.1 1.1 0.64 10.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02300.1 - 0.0064 16.1 0.7 0.041 13.6 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02300.1 - 0.015 14.8 0.9 0.096 12.3 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3116 PF11313.3 EFX02300.1 - 0.028 14.0 0.1 0.065 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3116) MIT PF04212.13 EFX02300.1 - 0.052 13.4 1.4 0.13 12.1 0.1 2.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 EFX02300.1 - 0.073 13.0 2.8 0.17 11.8 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFX02300.1 - 0.21 11.2 2.4 0.62 9.7 0.1 2.6 2 1 0 2 2 2 0 TPR repeat TPR_14 PF13428.1 EFX02300.1 - 0.21 12.2 2.4 21 6.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.11 EFX02301.1 - 1.6e-48 165.2 26.0 2.9e-47 161.1 15.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02301.1 - 3.1e-11 42.5 15.4 9e-11 41.0 6.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter ATG22 PF11700.3 EFX02301.1 - 8e-05 21.3 3.7 8e-05 21.3 2.6 2.8 2 2 1 3 3 3 1 Vacuole effluxer Atg22 like MFS_3 PF05977.8 EFX02301.1 - 0.00011 20.5 6.5 0.00011 20.5 4.5 1.6 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_1_like PF12832.2 EFX02301.1 - 0.0027 17.4 2.2 0.88 9.4 0.2 3.4 3 0 0 3 3 3 1 MFS_1 like family DUF3353 PF11833.3 EFX02301.1 - 1.2 8.5 14.2 0.3 10.5 3.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) Peptidase_S8 PF00082.17 EFX02302.1 - 6.9e-44 150.0 17.0 6.9e-44 150.0 11.8 1.7 2 0 0 2 2 2 1 Subtilase family Zn_clus PF00172.13 EFX02303.1 - 0.00038 20.3 8.4 0.0044 16.8 5.8 2.3 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Yippee-Mis18 PF03226.9 EFX02304.1 - 2.9e-18 65.6 0.0 5.3e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PT-VENN PF04829.8 EFX02305.1 - 1.8 8.2 8.8 0.58 9.7 0.4 2.9 2 1 0 2 2 2 0 Pre-toxin domain with VENN motif CWC25 PF12542.3 EFX02306.1 - 2.5e-21 75.8 0.0 2.5e-21 75.8 0.0 3.8 4 1 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.4 EFX02306.1 - 1.4e-10 41.0 8.4 1.4e-10 41.0 5.8 2.9 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR UCH PF00443.24 EFX02307.1 - 1.3e-28 99.8 0.0 4.7e-28 98.0 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX02307.1 - 3.3e-13 49.7 0.0 1.3e-12 47.8 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pap_E4 PF02711.9 EFX02308.1 - 0.015 16.1 1.7 0.042 14.6 1.2 1.7 1 0 0 1 1 1 0 E4 protein LIN37 PF15306.1 EFX02308.1 - 0.058 13.3 0.9 0.11 12.5 0.7 1.4 1 0 0 1 1 1 0 LIN37 Na_Ca_ex PF01699.19 EFX02310.1 - 6.5e-26 90.5 30.9 1.7e-16 60.1 5.7 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein RICTOR_N PF14664.1 EFX02311.1 - 2.5e-138 460.7 6.2 3.9e-138 460.0 4.3 1.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 EFX02311.1 - 2.2e-63 213.2 3.9 1.6e-33 115.6 0.0 4.0 4 1 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, middle domain Phos_pyr_kin PF08543.7 EFX02311.1 - 1.5e-49 168.4 0.3 1.1e-23 83.7 0.6 2.5 1 1 1 2 2 2 2 Phosphomethylpyrimidine kinase RICTOR_V PF14668.1 EFX02311.1 - 2e-26 91.7 0.3 1.3e-25 89.0 0.1 2.6 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.1 EFX02311.1 - 3.8e-19 68.7 0.5 1.3e-08 34.7 0.0 3.8 3 1 1 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain HR1 PF02185.11 EFX02311.1 - 5.7e-12 45.1 4.9 5.7e-12 45.1 3.4 2.5 3 0 0 3 3 3 1 Hr1 repeat TENA_THI-4 PF03070.11 EFX02311.1 - 2.2e-10 40.6 0.1 5.5e-10 39.3 0.1 1.6 1 0 0 1 1 1 1 TENA/THI-4/PQQC family DUF3336 PF11815.3 EFX02312.1 - 2.4e-31 108.2 1.1 4.2e-31 107.4 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EFX02312.1 - 1.8e-28 99.8 0.0 5.7e-28 98.2 0.0 1.9 1 0 0 1 1 1 1 Patatin-like phospholipase Nucleoplasmin PF03066.10 EFX02312.1 - 0.0024 17.4 1.4 0.0056 16.1 1.0 1.6 1 0 0 1 1 1 1 Nucleoplasmin NOA36 PF06524.7 EFX02312.1 - 1.2 8.3 4.6 1.9 7.6 3.2 1.3 1 0 0 1 1 1 0 NOA36 protein Glycos_transf_1 PF00534.15 EFX02313.1 - 1.1e-33 116.0 0.0 1.7e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EFX02313.1 - 5.4e-14 52.6 2.5 5.4e-14 52.6 1.7 3.0 2 1 1 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 EFX02313.1 - 1.1e-12 48.3 0.2 2.3e-12 47.2 0.2 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EFX02313.1 - 1e-11 44.9 0.0 4.5e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EFX02313.1 - 1.3e-05 24.9 1.0 0.00025 20.8 0.0 2.9 3 1 0 3 3 3 1 Glycosyltransferase Family 4 FR47 PF08445.5 EFX02313.1 - 0.11 12.2 0.5 0.59 9.9 0.0 2.4 3 0 0 3 3 3 0 FR47-like protein Nif11 PF07862.6 EFX02313.1 - 1.3 9.0 4.0 22 5.0 0.1 2.8 3 0 0 3 3 3 0 Nitrogen fixation protein of unknown function GST_C_3 PF14497.1 EFX02315.1 - 1.2e-09 38.5 0.0 1.9e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EFX02315.1 - 1.6e-07 31.4 0.0 3.7e-06 26.9 0.0 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFX02315.1 - 4.6e-05 23.3 0.0 7.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFX02315.1 - 9.7e-05 22.5 0.0 0.00037 20.6 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFX02315.1 - 0.00017 21.4 0.7 0.00035 20.4 0.5 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFX02315.1 - 0.054 13.4 0.0 0.17 11.9 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain HLH PF00010.21 EFX02316.1 - 2.4e-11 43.1 0.4 2.4e-11 43.1 0.3 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MerR-DNA-bind PF09278.6 EFX02316.1 - 0.15 12.4 2.8 0.37 11.2 1.9 1.6 1 0 0 1 1 1 0 MerR, DNA binding RAP1 PF07218.6 EFX02316.1 - 0.27 9.2 6.6 0.29 9.1 4.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HHV6-IE PF03753.8 EFX02316.1 - 0.48 7.8 6.9 0.58 7.5 4.8 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein FAD_binding_3 PF01494.14 EFX02317.1 - 1.1e-07 31.2 3.7 1.2e-06 27.8 2.4 2.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX02317.1 - 0.0074 16.1 0.1 0.017 14.9 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX02317.1 - 0.031 14.2 0.1 0.073 13.1 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFX02317.1 - 0.036 14.1 0.1 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX02317.1 - 0.34 11.3 1.1 1.1 9.7 0.7 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF948 PF06103.6 EFX02318.1 - 0.22 11.4 2.2 5 7.0 0.0 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Glyco_hydro_16 PF00722.16 EFX02319.1 - 6.2e-18 64.7 2.0 2.3e-17 62.8 1.4 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.10 EFX02319.1 - 1.3e-08 33.4 3.5 1.7e-05 23.2 0.3 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) peroxidase PF00141.18 EFX02320.1 - 2e-29 102.7 0.2 3.8e-29 101.8 0.0 1.5 2 0 0 2 2 2 1 Peroxidase Glyco_tranf_2_3 PF13641.1 EFX02320.1 - 4.6e-18 65.8 0.2 8.7e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EFX02320.1 - 0.004 16.4 0.1 0.98 8.6 0.1 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EFX02320.1 - 0.031 13.9 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 FAD_binding_3 PF01494.14 EFX02321.1 - 2.2e-21 76.3 0.1 4.5e-21 75.3 0.1 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX02321.1 - 1.2e-12 47.4 9.1 2.3e-06 26.7 3.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX02321.1 - 9.4e-09 35.1 0.3 3.2e-08 33.4 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 EFX02321.1 - 9.5e-09 34.3 1.2 0.012 14.2 0.0 3.1 3 0 0 3 3 3 3 Tryptophan halogenase Pyr_redox PF00070.22 EFX02321.1 - 1.5e-06 28.4 0.2 0.00053 20.3 0.3 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX02321.1 - 4e-06 25.5 1.7 0.0016 16.9 0.7 2.1 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.7 EFX02321.1 - 4.2e-06 25.9 1.1 0.026 13.4 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.2 EFX02321.1 - 5.7e-06 25.6 2.1 1.3e-05 24.4 1.4 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX02321.1 - 6.5e-06 25.2 5.5 1.6e-05 23.9 3.8 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 EFX02321.1 - 4.6e-05 23.5 0.3 0.00016 21.7 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX02321.1 - 5.6e-05 23.0 2.5 0.00051 19.9 1.8 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX02321.1 - 0.00012 21.2 0.7 0.00038 19.6 0.5 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.1 EFX02321.1 - 0.00042 20.1 2.2 0.0031 17.2 1.6 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding Amino_oxidase PF01593.19 EFX02321.1 - 0.0049 15.9 4.4 0.16 11.0 0.6 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase GIDA PF01134.17 EFX02321.1 - 0.0091 14.8 4.0 0.035 12.9 3.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.9 EFX02321.1 - 0.032 13.6 0.2 0.05 12.9 0.2 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Strep_67kDa_ant PF06100.6 EFX02321.1 - 0.038 12.3 0.1 0.094 11.0 0.1 1.5 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family 3HCDH_N PF02737.13 EFX02321.1 - 0.051 13.2 2.2 0.092 12.3 1.5 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EFX02321.1 - 0.088 12.3 0.8 0.19 11.2 0.6 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.18 EFX02321.1 - 0.092 12.4 0.5 0.16 11.7 0.4 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SE PF08491.5 EFX02321.1 - 0.19 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase Uricase PF01014.13 EFX02322.1 - 2e-85 283.8 1.9 7.8e-45 152.3 0.3 2.0 2 0 0 2 2 2 2 Uricase GMP_synt_C PF00958.17 EFX02322.1 - 0.019 14.6 0.0 0.048 13.3 0.0 1.4 1 1 0 1 1 1 0 GMP synthase C terminal domain Hexapep PF00132.19 EFX02324.1 - 4.7e-09 35.3 7.1 2e-05 23.9 1.1 4.3 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EFX02324.1 - 0.00069 19.1 6.3 0.0013 18.2 0.1 3.7 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase AMP-binding PF00501.23 EFX02325.1 - 1.5e-88 296.9 0.7 1.9e-88 296.6 0.5 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX02325.1 - 1e-14 55.1 1.3 3.1e-14 53.6 0.0 2.6 2 1 1 3 3 3 1 AMP-binding enzyme C-terminal domain HEAT PF02985.17 EFX02326.1 - 0.0034 17.3 1.4 0.05 13.6 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.1 EFX02326.1 - 0.005 17.1 0.0 0.034 14.4 0.0 2.5 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.1 EFX02326.1 - 0.11 13.0 1.9 1.9 9.0 0.0 3.7 4 1 1 5 5 5 0 HEAT-like repeat Arm PF00514.18 EFX02326.1 - 0.63 9.9 3.1 0.84 9.5 0.1 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Acetyltransf_1 PF00583.19 EFX02327.1 - 2.5e-17 62.6 0.1 3.5e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFX02327.1 - 3.7e-08 33.0 0.0 5.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 EFX02327.1 - 3.2e-07 30.4 0.0 4.9e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFX02327.1 - 3.4e-07 30.4 0.0 4.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFX02327.1 - 0.00034 20.7 0.0 0.00051 20.2 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFX02327.1 - 0.0045 16.9 0.0 0.0073 16.2 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX02327.1 - 0.057 13.2 0.0 0.084 12.7 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 EFX02327.1 - 0.11 12.0 0.0 0.31 10.6 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain RNR_inhib PF08591.5 EFX02328.1 - 2.6e-18 66.7 0.0 1.7e-17 64.1 0.0 2.3 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor SIP1 PF04938.7 EFX02328.1 - 0.0019 17.5 0.6 0.0052 16.1 0.1 2.0 2 0 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Peptidase_M16_C PF05193.16 EFX02329.1 - 2e-55 187.2 0.0 3e-55 186.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EFX02329.1 - 4.5e-43 146.5 0.0 1.1e-42 145.2 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) PEPcase PF00311.12 EFX02330.1 - 0.035 11.9 0.1 0.041 11.7 0.1 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Sgf11 PF08209.6 EFX02332.1 - 0.047 13.0 3.6 0.099 11.9 2.5 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) DUF2732 PF10809.3 EFX02332.1 - 0.11 12.0 0.5 0.24 10.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2732) Glyco_hydro_18 PF00704.23 EFX02333.1 - 1e-20 74.5 4.8 2.8e-20 73.0 0.8 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 CBM_1 PF00734.13 EFX02333.1 - 3.3e-09 36.2 13.3 3.3e-09 36.2 9.2 2.6 2 0 0 2 2 2 1 Fungal cellulose binding domain Hexokinase_1 PF00349.16 EFX02334.1 - 6.9e-64 214.9 0.0 1.2e-63 214.1 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 EFX02334.1 - 3.3e-63 213.1 0.0 7.9e-63 211.8 0.0 1.6 1 1 0 1 1 1 1 Hexokinase ATP_bind_1 PF03029.12 EFX02335.1 - 1.5e-74 250.5 0.0 2.3e-74 249.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CTP_transf_2 PF01467.21 EFX02335.1 - 4.7e-10 39.7 0.0 7.3e-09 35.8 0.0 2.4 1 1 0 1 1 1 1 Cytidylyltransferase AAA_22 PF13401.1 EFX02335.1 - 0.00033 20.7 0.0 0.0012 19.0 0.0 2.0 2 0 0 2 2 1 1 AAA domain G-alpha PF00503.15 EFX02335.1 - 0.0023 16.6 0.0 0.057 12.0 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.22 EFX02335.1 - 0.0036 16.7 0.0 0.071 12.5 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ArgK PF03308.11 EFX02335.1 - 0.0045 15.7 0.0 0.18 10.5 0.0 2.3 2 0 0 2 2 2 1 ArgK protein Zeta_toxin PF06414.7 EFX02335.1 - 0.013 14.6 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 EFX02335.1 - 0.014 15.2 0.0 0.033 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFX02335.1 - 0.017 15.9 0.1 0.11 13.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 EFX02335.1 - 0.019 14.5 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX02335.1 - 0.019 14.9 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.17 EFX02335.1 - 0.021 14.2 0.0 0.069 12.5 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Miro PF08477.8 EFX02335.1 - 0.028 14.9 0.0 11 6.4 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein AAA_10 PF12846.2 EFX02335.1 - 0.048 13.1 0.0 0.13 11.6 0.0 2.0 2 1 0 2 2 2 0 AAA-like domain NB-ARC PF00931.17 EFX02335.1 - 0.049 12.4 0.0 0.097 11.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Mnd1 PF03962.10 EFX02335.1 - 0.12 12.0 0.9 0.5 10.0 0.0 2.1 2 0 0 2 2 2 0 Mnd1 family Arf PF00025.16 EFX02335.1 - 0.12 11.6 0.0 3.2 6.9 0.0 2.7 3 0 0 3 3 3 0 ADP-ribosylation factor family MobB PF03205.9 EFX02335.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 EFX02335.1 - 0.17 11.5 0.0 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF4593 PF15263.1 EFX02337.1 - 0.064 13.1 2.4 0.15 11.9 1.7 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4593) AA_kinase PF00696.23 EFX02338.1 - 2.5e-24 86.1 0.0 4.8e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family DUF619 PF04768.8 EFX02338.1 - 6e-09 35.5 0.1 3.7e-08 32.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Raptor_N PF14538.1 EFX02339.1 - 4.6e-64 214.9 0.0 7.7e-64 214.1 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.27 EFX02339.1 - 8.4e-07 28.6 6.7 0.62 10.0 0.1 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 EFX02339.1 - 0.0011 18.7 0.1 0.21 11.3 0.0 2.6 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Atx10homo_assoc PF09759.4 EFX02339.1 - 0.01 15.5 0.1 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.17 EFX02339.1 - 0.78 9.9 3.8 17 5.8 0.1 4.6 5 0 0 5 5 5 0 HEAT repeat Glyco_hydro_3 PF00933.16 EFX02340.1 - 6.3e-94 314.3 0.0 1e-93 313.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX02340.1 - 1.4e-51 175.1 0.6 7.4e-51 172.8 0.4 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX02340.1 - 5.7e-14 51.8 0.0 9.8e-14 51.0 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Abhydrolase_3 PF07859.8 EFX02341.1 - 5.5e-27 94.7 0.0 9.9e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EFX02341.1 - 1.4e-06 27.3 0.2 6.2e-06 25.2 0.0 2.0 3 0 0 3 3 3 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EFX02341.1 - 2.7e-05 23.9 0.0 5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX02341.1 - 0.00066 19.6 4.5 0.00097 19.0 0.9 2.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.7 EFX02341.1 - 0.0016 16.9 0.0 0.0027 16.2 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 EFX02341.1 - 0.0081 15.4 0.0 0.021 14.0 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Thioesterase PF00975.15 EFX02341.1 - 0.037 14.2 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain P5CR_dimer PF14748.1 EFX02342.1 - 1.7e-37 127.6 0.9 1.7e-37 127.6 0.6 1.8 2 1 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 EFX02342.1 - 3.5e-15 56.1 0.6 9.1e-15 54.8 0.4 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 EFX02342.1 - 0.01 15.6 0.1 0.021 14.6 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 EFX02342.1 - 0.043 13.5 1.9 0.047 13.4 0.1 2.0 1 1 1 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PDH PF02153.12 EFX02343.1 - 6.7e-11 41.5 0.0 9.1e-11 41.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase His_biosynth PF00977.16 EFX02344.1 - 3.6e-46 157.2 0.2 1.5e-45 155.2 0.2 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 EFX02344.1 - 4.9e-27 94.6 0.0 7.5e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.14 EFX02344.1 - 3.7e-07 29.9 0.0 7.7e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 EFX02344.1 - 1.1e-06 28.3 0.0 2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Dus PF01207.12 EFX02344.1 - 0.0024 16.7 0.1 0.0046 15.8 0.0 1.4 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Peptidase_C26 PF07722.8 EFX02344.1 - 0.0078 15.6 0.1 0.095 12.1 0.1 2.2 1 1 0 1 1 1 1 Peptidase C26 Protoglobin PF11563.3 EFX02346.1 - 4.8e-56 188.8 0.0 5.8e-56 188.5 0.0 1.1 1 0 0 1 1 1 1 Protoglobin Glyco_hydro_cc PF11790.3 EFX02347.1 - 1e-62 211.7 0.6 1.1e-61 208.3 0.4 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_39 PF01229.12 EFX02347.1 - 0.14 10.4 0.0 0.19 10.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 Bac_luciferase PF00296.15 EFX02348.1 - 3.8e-57 193.7 0.8 3.8e-57 193.7 0.5 1.5 2 0 0 2 2 2 1 Luciferase-like monooxygenase GFA PF04828.9 EFX02349.1 - 1.2e-12 47.6 0.4 1.7e-12 47.1 0.3 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme ADK_lid PF05191.9 EFX02349.1 - 0.33 10.6 0.2 0.33 10.6 0.1 2.6 2 1 1 3 3 3 0 Adenylate kinase, active site lid RRM_1 PF00076.17 EFX02351.1 - 3.8e-18 64.8 0.0 5.2e-12 45.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX02351.1 - 3.9e-12 45.9 0.0 1.5e-05 24.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) TFIIIC_sub6 PF10419.4 EFX02352.1 - 5.2e-13 48.2 0.1 1.2e-12 47.0 0.0 1.7 2 0 0 2 2 2 1 TFIIIC subunit BTB PF00651.26 EFX02354.1 - 6.8e-08 32.4 0.0 1.9e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain ketoacyl-synt PF00109.21 EFX02355.1 - 8.5e-77 258.0 0.1 2.7e-76 256.4 0.1 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX02355.1 - 1.5e-58 198.6 2.8 5.3e-58 196.8 2.0 2.1 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EFX02355.1 - 3.3e-53 180.0 3.6 3.3e-53 180.0 2.5 3.9 3 0 0 3 3 3 1 KR domain PS-DH PF14765.1 EFX02355.1 - 2.8e-48 164.6 2.6 2.8e-48 164.6 1.8 2.3 2 0 0 2 2 2 1 Polyketide synthase dehydratase adh_short PF00106.20 EFX02355.1 - 2.9e-44 150.9 4.3 2.9e-44 150.9 3.0 5.7 6 1 0 6 6 5 2 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFX02355.1 - 5.9e-37 126.1 0.5 2.5e-36 124.1 0.3 2.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.21 EFX02355.1 - 2.6e-19 69.0 0.1 1.7e-18 66.4 0.0 2.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 EFX02355.1 - 1.8e-14 54.0 0.0 5e-14 52.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.1 EFX02355.1 - 3e-13 50.7 1.6 1e-12 49.0 0.1 3.0 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.1 EFX02355.1 - 3.5e-13 49.5 0.0 8.3e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 EFX02355.1 - 2.9e-08 33.8 0.1 8.1e-08 32.4 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_18 PF12847.2 EFX02355.1 - 1.3e-07 32.1 0.0 9.5e-07 29.3 0.0 2.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02355.1 - 2.7e-07 30.2 0.0 6.5e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02355.1 - 6.7e-07 29.7 0.0 2.2e-06 28.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.7 EFX02355.1 - 4.5e-06 26.3 0.2 1.3e-05 24.9 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.18 EFX02355.1 - 0.00021 20.4 1.7 0.00045 19.2 0.5 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.13 EFX02355.1 - 0.023 13.8 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ribosomal_S30 PF04758.9 EFX02356.1 - 1.9e-28 97.9 6.1 2.1e-28 97.8 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Ferritin_2 PF13668.1 EFX02357.1 - 1.1e-05 25.4 0.0 2.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Ferritin-like domain PAT1 PF09770.4 EFX02358.1 - 0.2 9.8 11.2 0.23 9.6 7.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 EFX02358.1 - 0.61 9.9 7.0 0.66 9.8 4.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EF-hand_4 PF12763.2 EFX02359.1 - 1.3e-05 24.8 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 EFX02359.1 - 0.00094 18.3 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 EFX02359.1 - 0.0064 16.0 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EFX02359.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Pkinase PF00069.20 EFX02360.1 - 3e-52 177.3 0.0 2.5e-48 164.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02360.1 - 6.5e-33 113.8 0.0 1.9e-30 105.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFX02360.1 - 0.00015 20.8 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EFX02360.1 - 0.0022 16.8 0.0 0.0033 16.2 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 EFX02360.1 - 0.066 11.9 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.18 EFX02360.1 - 0.17 11.5 0.1 0.46 10.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family SNF2_N PF00176.18 EFX02361.1 - 2.2e-07 29.9 0.0 4.6e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX02361.1 - 0.00031 20.5 0.0 0.00083 19.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AMP-binding PF00501.23 EFX02362.1 - 1.3e-70 237.8 0.0 1.6e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX02362.1 - 5.9e-08 33.5 0.1 1.2e-07 32.5 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Gln-synt_C PF00120.19 EFX02363.1 - 2.5e-63 213.6 0.0 3e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 EFX02363.1 - 2.1e-19 68.8 0.0 3.5e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF3449 PF11931.3 EFX02364.1 - 1.8e-71 239.6 0.3 3.5e-71 238.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) zf-C2H2_jaz PF12171.3 EFX02364.1 - 1e-06 28.6 4.5 1.6e-05 24.9 0.1 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX02364.1 - 3.4e-06 27.0 6.8 7.1e-06 26.0 0.2 2.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EFX02364.1 - 0.012 15.6 5.0 0.1 12.7 0.0 3.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF951 PF06107.6 EFX02364.1 - 0.019 14.4 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) DUF1019 PF06254.6 EFX02364.1 - 0.094 12.8 0.5 0.35 11.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1019) DUF4407 PF14362.1 EFX02364.1 - 1.3 7.9 5.5 2.5 6.9 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-DBF PF07535.7 EFX02364.1 - 2.7 7.7 6.9 0.32 10.6 0.1 2.4 2 0 0 2 2 2 0 DBF zinc finger Cupin_2 PF07883.6 EFX02365.1 - 1.3e-21 75.8 1.6 3e-14 52.2 0.1 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_1 PF00190.17 EFX02365.1 - 0.00015 21.1 0.0 0.53 9.7 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_3 PF05899.7 EFX02365.1 - 0.00095 18.5 0.0 1.2 8.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) CENP-C_C PF11699.3 EFX02365.1 - 0.056 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Mif2/CENP-C like AraC_binding PF02311.14 EFX02365.1 - 0.092 12.4 0.6 5.4 6.7 0.1 2.5 2 0 0 2 2 2 0 AraC-like ligand binding domain Hydrolase PF00702.21 EFX02366.1 - 1.7e-16 61.3 0.3 1.1e-11 45.5 0.2 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EFX02366.1 - 2.4e-12 46.3 0.0 5.4e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 EFX02366.1 - 1.1e-11 45.3 0.0 2.5e-10 40.8 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX02366.1 - 1.6e-10 40.7 0.0 4.8e-10 39.2 0.0 1.9 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Fungal_trans PF04082.13 EFX02366.1 - 7.2e-06 25.0 0.0 1.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hydrolase_3 PF08282.7 EFX02366.1 - 0.0054 16.3 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase NPIP PF06409.6 EFX02366.1 - 0.027 13.2 0.0 0.051 12.3 0.0 1.3 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) PARP_regulatory PF01358.13 EFX02366.1 - 0.1 11.2 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit DUF1688 PF07958.6 EFX02367.1 - 5.8e-172 571.9 0.0 1.5e-102 343.2 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1688) SnoaL_2 PF12680.2 EFX02367.1 - 0.13 12.7 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 SnoaL-like domain DUF1639 PF07797.9 EFX02369.1 - 0.061 12.7 0.1 0.13 11.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Sugar_tr PF00083.19 EFX02370.1 - 5e-78 262.6 25.8 6e-78 262.4 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX02370.1 - 9.9e-26 90.2 29.9 3.5e-24 85.1 16.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Arginosuc_synth PF00764.14 EFX02371.1 - 1.4e-148 495.0 0.0 1.6e-148 494.8 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.8 EFX02371.1 - 0.004 16.4 0.0 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 EFX02371.1 - 0.038 13.4 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase tRNA_Me_trans PF03054.11 EFX02371.1 - 0.05 12.1 0.0 0.071 11.6 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase AAA_11 PF13086.1 EFX02372.1 - 3.5e-16 59.5 0.0 7.2e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.1 EFX02372.1 - 5.3e-14 52.0 0.0 9.5e-14 51.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AviRa PF11599.3 EFX02372.1 - 0.16 10.9 0.0 1.1 8.2 0.0 2.0 2 0 0 2 2 2 0 RRNA methyltransferase AviRa Complex1_LYR PF05347.10 EFX02373.1 - 5.4e-07 29.3 1.9 1.1e-06 28.3 1.4 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFX02373.1 - 2.5e-06 27.5 0.9 5.2e-06 26.5 0.6 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Gtr1_RagA PF04670.7 EFX02374.1 - 1.6e-91 305.5 0.1 4.4e-91 304.1 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Arf PF00025.16 EFX02374.1 - 9.2e-09 34.7 0.0 1.4e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EFX02374.1 - 5.4e-08 32.3 0.1 9.9e-08 31.5 0.1 1.4 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 EFX02374.1 - 1.4e-06 28.2 0.0 2.4e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 EFX02374.1 - 8.8e-06 26.2 0.8 1.6e-05 25.3 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein AAA_29 PF13555.1 EFX02374.1 - 0.0011 18.4 0.5 0.0097 15.4 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain SRPRB PF09439.5 EFX02374.1 - 0.0092 15.2 0.0 0.019 14.1 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 EFX02374.1 - 0.04 14.2 0.1 0.04 14.2 0.1 2.1 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.8 EFX02374.1 - 0.052 12.4 1.6 0.055 12.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) G-alpha PF00503.15 EFX02374.1 - 0.13 10.9 3.1 1.4 7.4 0.1 2.9 3 0 0 3 3 3 0 G-protein alpha subunit DUF258 PF03193.11 EFX02374.1 - 0.31 10.2 0.0 0.31 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Ank_5 PF13857.1 EFX02376.1 - 7.2e-06 26.0 1.3 1.9e-05 24.7 0.9 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 EFX02376.1 - 0.019 14.7 0.7 0.048 13.4 0.5 1.7 1 0 0 1 1 1 0 Ankyrin repeat Ank_2 PF12796.2 EFX02376.1 - 0.02 15.1 0.1 0.067 13.5 0.1 1.9 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX02376.1 - 0.072 13.6 0.1 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX02376.1 - 0.077 13.2 0.1 0.33 11.3 0.1 2.1 1 0 0 1 1 1 0 Ankyrin repeat Nop52 PF05997.7 EFX02377.1 - 1.4e-37 129.2 0.1 5.4e-33 114.2 0.1 2.4 2 1 0 2 2 2 2 Nucleolar protein,Nop52 Transket_pyr PF02779.19 EFX02379.1 - 1.2e-63 213.7 0.0 2.6e-63 212.7 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 EFX02379.1 - 3e-56 190.3 0.0 5.8e-56 189.4 0.0 1.5 2 0 0 2 2 2 1 Dehydrogenase E1 component RabGAP-TBC PF00566.13 EFX02380.1 - 1.7e-37 128.9 0.0 1e-20 74.1 0.0 3.6 3 0 0 3 3 3 3 Rab-GTPase-TBC domain Rad9 PF04139.8 EFX02381.1 - 5.3e-17 61.7 0.0 6.5e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Rad9 Exo_endo_phos PF03372.18 EFX02382.1 - 5.1e-14 52.8 0.8 1.4e-08 35.0 0.4 2.4 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family SR-25 PF10500.4 EFX02382.1 - 0.16 11.4 5.4 0.44 9.9 3.8 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 EFX02382.1 - 6.5 6.8 8.1 12 6.0 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) CwfJ_C_1 PF04677.10 EFX02383.1 - 8.2e-25 86.8 0.0 1.3e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 EFX02383.1 - 1.1e-22 80.3 0.0 2.7e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 HSP70 PF00012.15 EFX02384.1 - 4.4e-06 24.8 0.2 0.00018 19.5 0.1 2.1 2 0 0 2 2 2 2 Hsp70 protein zf-SAP30 PF13866.1 EFX02384.1 - 0.01 15.4 0.1 0.023 14.3 0.1 1.5 1 0 0 1 1 1 0 SAP30 zinc-finger MFS_1 PF07690.11 EFX02385.1 - 1.4e-33 116.0 29.5 1.4e-33 116.0 20.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Lipase_3 PF01764.20 EFX02385.1 - 0.049 13.2 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Zn_clus PF00172.13 EFX02386.1 - 6e-07 29.2 8.7 1.1e-06 28.4 6.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UQ_con PF00179.21 EFX02387.1 - 1.3e-19 70.0 0.0 2.4e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 EFX02387.1 - 0.033 13.8 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 UEV domain C1_4 PF07975.7 EFX02387.1 - 0.2 11.7 3.8 0.68 9.9 2.6 1.9 1 1 1 2 2 2 0 TFIIH C1-like domain MT0933_antitox PF14013.1 EFX02388.1 - 0.43 10.7 2.7 1.2 9.3 1.9 1.9 1 1 0 1 1 1 0 MT0933-like antitoxin protein Prominin PF05478.6 EFX02389.1 - 0.14 9.6 8.2 0.0058 14.2 1.8 1.4 2 0 0 2 2 2 0 Prominin ApoO PF09769.4 EFX02389.1 - 0.99 9.0 3.8 3.7 7.2 2.6 2.0 1 1 0 1 1 1 0 Apolipoprotein O LMBR1 PF04791.11 EFX02389.1 - 1.2 7.6 2.0 2.1 6.8 1.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Syntaxin_2 PF14523.1 EFX02389.1 - 5 7.2 9.2 2.6 8.1 3.1 2.4 1 1 1 2 2 2 0 Syntaxin-like protein ChAPs PF09295.5 EFX02390.1 - 3.5e-157 523.2 0.0 4.9e-157 522.7 0.0 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.1 EFX02390.1 - 7.4e-06 26.1 6.6 0.75 10.5 0.0 5.2 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX02390.1 - 6e-05 22.6 1.0 0.5 10.0 0.1 3.3 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.1 EFX02390.1 - 7.6e-05 22.9 0.5 0.21 11.9 0.0 3.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02390.1 - 0.00038 20.1 3.6 0.31 11.0 1.6 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFX02390.1 - 0.00076 19.1 1.5 0.27 11.1 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02390.1 - 0.0021 17.7 0.5 1.8 8.5 0.4 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFX02390.1 - 0.0055 16.5 3.2 2.1 8.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2007 PF09413.5 EFX02390.1 - 0.013 15.3 0.1 0.087 12.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2007) TPR_12 PF13424.1 EFX02390.1 - 0.041 13.8 1.1 2.3 8.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX02390.1 - 0.075 13.5 6.1 5.5 7.6 0.2 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02390.1 - 0.092 12.3 1.4 16 5.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFX02390.1 - 1.9 9.2 9.6 32 5.3 1.3 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat JAB PF01398.16 EFX02391.1 - 3e-09 36.6 0.1 1.5e-07 31.1 0.1 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Glyco_hydro_42 PF02449.10 EFX02392.1 - 6.4e-11 41.9 0.0 9.8e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.14 EFX02392.1 - 5.5e-05 22.6 0.0 0.00042 19.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Ank_2 PF12796.2 EFX02393.1 - 1.1e-07 32.0 0.0 2.7e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Zn_clus PF00172.13 EFX02393.1 - 1.2e-07 31.5 7.2 2.6e-07 30.4 5.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_4 PF13637.1 EFX02393.1 - 1.7e-05 25.1 0.0 0.00038 20.8 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.25 EFX02393.1 - 6.2e-05 22.6 0.0 0.31 10.9 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 EFX02393.1 - 0.00016 21.5 0.0 0.87 10.0 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.1 EFX02393.1 - 0.0056 16.8 0.0 5.1 7.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) DUF1546 PF07571.8 EFX02394.1 - 5.8e-24 84.0 0.0 1.5e-23 82.7 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 EFX02394.1 - 5.5e-20 71.0 0.0 1.1e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 EFX02394.1 - 0.0042 17.1 0.0 0.0078 16.3 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFX02394.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GXWXG PF14231.1 EFX02395.1 - 3.2e-24 84.3 0.1 5.7e-24 83.5 0.1 1.4 1 0 0 1 1 1 1 GXWXG protein DUF4334 PF14232.1 EFX02395.1 - 3.1e-22 77.9 0.2 6.6e-22 76.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4334) XAP5 PF04921.9 EFX02397.1 - 7.7e-72 241.7 0.0 1.1e-71 241.2 0.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator Gly-zipper_OmpA PF13436.1 EFX02397.1 - 0.62 9.7 14.3 1.4 8.5 9.9 1.5 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain TPR_11 PF13414.1 EFX02398.1 - 2.6e-21 75.0 8.1 2e-11 43.3 0.1 3.3 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 EFX02398.1 - 1.4e-16 59.3 5.0 1.3e-08 34.0 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02398.1 - 2.5e-16 58.2 3.6 1.8e-06 27.4 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02398.1 - 1.2e-13 50.8 0.1 1e-07 31.8 0.0 3.2 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02398.1 - 1.5e-12 46.3 2.0 3e-05 23.4 0.0 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFX02398.1 - 1.7e-09 36.7 0.1 4.8e-07 29.0 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX02398.1 - 1.7e-08 34.3 0.1 0.13 12.7 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX02398.1 - 5.4e-07 29.3 0.1 0.0046 17.0 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat PB1 PF00564.19 EFX02398.1 - 1.7e-05 24.3 0.5 3.7e-05 23.3 0.3 1.5 1 0 0 1 1 1 1 PB1 domain TPR_9 PF13371.1 EFX02398.1 - 4.7e-05 23.1 0.3 0.39 10.5 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX02398.1 - 0.00014 22.4 0.5 0.0013 19.3 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX02398.1 - 0.00036 20.9 0.1 0.021 15.4 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 EFX02398.1 - 0.021 14.9 1.6 0.065 13.3 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3808 PF10300.4 EFX02398.1 - 0.047 12.2 0.1 0.08 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_19 PF14559.1 EFX02398.1 - 0.11 12.8 0.1 1 9.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 EFX02398.1 - 0.12 12.2 1.1 5.8 6.9 0.0 3.9 4 1 1 5 5 4 0 Tetratricopeptide repeat Apc5 PF12862.2 EFX02398.1 - 0.13 12.1 0.1 0.41 10.5 0.0 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 5 TPR_4 PF07721.9 EFX02398.1 - 0.13 12.7 1.2 36 5.1 0.0 3.8 4 1 0 4 4 2 0 Tetratricopeptide repeat RabGAP-TBC PF00566.13 EFX02399.1 - 2.4e-44 151.4 0.0 2.4e-44 151.4 0.0 2.4 3 0 0 3 3 3 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.1 EFX02399.1 - 8.7e-07 28.3 1.0 0.0067 16.2 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 EFX02399.1 - 4.6e-05 23.4 0.1 0.00073 19.6 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 EFX02399.1 - 6.6e-05 21.9 0.1 0.11 11.8 0.2 3.4 3 0 0 3 3 3 2 EF hand GRAM PF02893.15 EFX02399.1 - 0.00011 21.5 0.0 0.00028 20.3 0.0 1.7 1 1 0 1 1 1 1 GRAM domain EF-hand_5 PF13202.1 EFX02399.1 - 0.01 15.1 0.4 0.12 11.7 0.3 2.6 2 0 0 2 2 2 0 EF hand Med15 PF09606.5 EFX02399.1 - 0.048 11.8 5.9 0.11 10.7 4.1 1.5 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BUD22 PF09073.5 EFX02399.1 - 0.68 8.9 11.8 0.096 11.7 4.5 2.1 3 0 0 3 3 3 0 BUD22 QRPTase_C PF01729.14 EFX02400.1 - 1.8e-52 177.2 0.1 2.2e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 EFX02400.1 - 1.4e-22 79.3 0.0 4e-22 77.8 0.0 1.8 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain Kelch_4 PF13418.1 EFX02401.1 - 5.3e-40 134.9 6.7 9.5e-09 34.8 0.6 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 EFX02401.1 - 8.8e-32 108.5 21.8 5.5e-08 32.7 0.1 7.1 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_5 PF13854.1 EFX02401.1 - 2.7e-31 106.9 3.1 2.8e-08 33.5 0.1 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 EFX02401.1 - 5.4e-28 95.9 4.7 2.7e-11 43.1 1.1 6.6 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.20 EFX02401.1 - 2e-27 94.4 1.2 1.3e-10 40.6 0.6 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 EFX02401.1 - 1.1e-18 66.1 5.4 8.3e-08 31.7 0.4 6.7 6 0 0 6 6 6 4 Kelch motif RAG2 PF03089.9 EFX02401.1 - 0.17 10.6 0.2 1.4 7.5 0.0 2.6 3 1 0 3 3 3 0 Recombination activating protein 2 PEX11 PF05648.9 EFX02402.1 - 1.9e-05 24.0 2.9 3.4e-05 23.2 2.0 1.4 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) bZIP_Maf PF03131.12 EFX02403.1 - 0.2 11.9 3.9 0.24 11.6 1.0 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor bZIP_1 PF00170.16 EFX02403.1 - 2.3 8.2 7.1 0.19 11.6 1.8 1.6 2 0 0 2 2 2 0 bZIP transcription factor Methyltransf_10 PF05971.7 EFX02405.1 - 3.3e-54 184.0 0.0 5.1e-54 183.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF890) Methyltransf_26 PF13659.1 EFX02405.1 - 9.1e-06 25.6 0.0 2.7e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02405.1 - 1.2e-05 25.8 0.0 6.4e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EFX02405.1 - 0.0005 19.4 0.0 0.0009 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EFX02405.1 - 0.029 13.4 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 EFX02405.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 AMP-binding PF00501.23 EFX02406.1 - 9.7e-79 264.6 0.0 1.2e-78 264.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX02406.1 - 4e-16 59.7 0.2 1.2e-15 58.2 0.1 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF946 PF06101.6 EFX02407.1 - 1.2e-08 33.4 0.2 8.6e-08 30.6 0.0 2.0 2 0 0 2 2 2 1 Plant protein of unknown function (DUF946) DUF3141 PF11339.3 EFX02407.1 - 0.085 11.1 0.1 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Ank_2 PF12796.2 EFX02408.1 - 2e-41 140.2 0.1 2.4e-16 59.8 0.0 4.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EFX02408.1 - 1.6e-35 117.6 0.0 1.5e-05 24.7 0.0 7.2 7 0 0 7 7 6 5 Ankyrin repeat Ank PF00023.25 EFX02408.1 - 3.6e-35 118.0 0.0 4.5e-06 26.2 0.0 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 EFX02408.1 - 4.7e-35 119.3 0.0 1.1e-10 41.7 0.0 5.5 5 1 2 7 7 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX02408.1 - 1.9e-20 72.3 0.0 1.3e-05 25.2 0.0 5.5 2 1 4 6 6 5 5 Ankyrin repeats (many copies) NACHT PF05729.7 EFX02408.1 - 9.4e-09 35.1 0.1 2.4e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EFX02408.1 - 1.1e-05 25.5 0.1 3.6e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX02408.1 - 0.00031 20.8 0.0 0.0023 18.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.9 EFX02408.1 - 0.0057 15.6 0.7 2.2 7.1 0.0 2.3 1 1 1 2 2 2 2 KAP family P-loop domain ABC_tran PF00005.22 EFX02408.1 - 0.015 15.5 0.0 0.058 13.7 0.0 2.0 2 0 0 2 2 1 0 ABC transporter AAA_18 PF13238.1 EFX02408.1 - 0.045 14.0 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 EFX02408.1 - 0.079 12.4 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 EFX02408.1 - 0.1 12.0 0.1 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain NB-ARC PF00931.17 EFX02408.1 - 0.13 11.0 0.0 0.26 10.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Miro PF08477.8 EFX02408.1 - 0.16 12.4 0.1 0.72 10.3 0.1 2.1 1 1 0 1 1 1 0 Miro-like protein AAA_19 PF13245.1 EFX02408.1 - 0.18 11.5 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Arch_ATPase PF01637.13 EFX02408.1 - 0.19 11.3 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase GTP_EFTU PF00009.22 EFX02409.1 - 1.3e-51 174.7 0.0 2.6e-51 173.7 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 EFX02409.1 - 3.5e-15 55.6 0.0 8.8e-15 54.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFX02409.1 - 5.2e-09 36.1 0.0 1.3e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EFX02409.1 - 1.4e-07 31.2 0.0 3.8e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 EFX02409.1 - 5.9e-07 29.0 0.0 6.8e-06 25.6 0.0 2.7 2 1 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.18 EFX02409.1 - 0.0086 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2947 PF11163.3 EFX02409.1 - 0.1 12.1 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) zf-C2HC5 PF06221.8 EFX02410.1 - 1.5e-20 72.7 5.9 2.4e-20 72.0 4.1 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Sigma70_ner PF04546.8 EFX02410.1 - 0.042 13.4 0.3 0.12 11.9 0.2 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF3665 PF12427.3 EFX02411.1 - 0.26 10.7 3.5 4.8 6.6 0.7 3.2 3 0 0 3 3 3 0 Branched-chain amino acid aminotransferase DUF3328 PF11807.3 EFX02413.1 - 1.6e-43 148.9 0.4 1.9e-43 148.6 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DapH_N PF08503.5 EFX02414.1 - 0.022 14.8 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal DEAD PF00270.24 EFX02415.1 - 1.1e-42 145.3 0.6 2.2e-42 144.4 0.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX02415.1 - 6.6e-28 96.3 0.2 1.8e-27 94.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.1 EFX02415.1 - 0.0049 16.4 1.0 0.012 15.1 0.7 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 EFX02415.1 - 0.0066 16.2 0.1 0.017 14.9 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFX02415.1 - 0.0086 14.9 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Flavi_DEAD PF07652.9 EFX02415.1 - 0.0092 15.7 0.2 0.033 13.9 0.1 2.0 1 1 0 1 1 1 1 Flavivirus DEAD domain Helicase_RecD PF05127.9 EFX02415.1 - 0.011 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_19 PF13245.1 EFX02415.1 - 0.022 14.5 0.2 0.056 13.2 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 EFX02415.1 - 0.041 14.0 0.4 0.12 12.4 0.3 1.8 1 1 0 1 1 1 0 AAA domain tRNA-synt_1b PF00579.20 EFX02415.1 - 0.063 12.3 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) AAA_11 PF13086.1 EFX02415.1 - 0.1 12.1 0.6 0.13 11.8 0.4 1.5 1 1 0 1 1 1 0 AAA domain RPE65 PF03055.10 EFX02417.1 - 1.3e-134 449.4 0.1 1.4e-134 449.2 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Fungal_trans PF04082.13 EFX02418.1 - 6.8e-05 21.8 0.0 0.00011 21.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_19 PF04672.7 EFX02418.1 - 0.16 11.1 0.0 0.32 10.2 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl methyltransferase DEAD PF00270.24 EFX02419.1 - 5e-45 153.0 0.0 1.2e-43 148.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX02419.1 - 2.2e-29 101.1 0.0 4.8e-29 100.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX02419.1 - 4.4e-05 23.3 0.0 0.0002 21.2 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 EFX02419.1 - 0.00032 19.2 0.0 0.016 13.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) DRTGG PF07085.7 EFX02419.1 - 0.019 14.5 0.0 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 DRTGG domain Helicase_C_2 PF13307.1 EFX02419.1 - 0.032 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain AAA PF00004.24 EFX02419.1 - 0.059 13.5 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF1777 PF08648.7 EFX02420.1 - 0.91 9.2 46.0 0.12 12.1 10.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1777) Glyco_transf_34 PF05637.7 EFX02421.1 - 4.1e-11 42.8 0.1 1.4e-08 34.5 0.0 2.5 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 EFX02421.1 - 0.00022 20.6 0.2 0.0026 17.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF273 Nop14 PF04147.7 EFX02421.1 - 0.039 11.8 17.9 0.05 11.5 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family GIY-YIG PF01541.19 EFX02422.1 - 1.2e-07 32.0 0.0 2.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H_2 PF13832.1 EFX02422.1 - 0.0016 18.3 0.7 0.003 17.5 0.5 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFX02422.1 - 0.0017 18.4 2.6 0.0032 17.5 1.8 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain FANCL_C PF11793.3 EFX02422.1 - 0.0025 17.7 3.9 0.0041 17.0 2.7 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain YdjO PF14169.1 EFX02422.1 - 0.042 13.2 0.3 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Cold-inducible protein YdjO T5orf172 PF10544.4 EFX02422.1 - 0.059 13.7 0.0 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 T5orf172 domain zf-RING_2 PF13639.1 EFX02422.1 - 0.29 10.9 7.9 0.46 10.3 5.5 1.3 1 0 0 1 1 1 0 Ring finger domain Prok-RING_1 PF14446.1 EFX02422.1 - 0.53 10.0 7.8 1.3 8.8 2.7 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Pro_isomerase PF00160.16 EFX02425.1 - 1.8e-48 164.6 0.0 2.1e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FHA PF00498.21 EFX02426.1 - 9.1e-09 35.3 0.1 1.6e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 FHA domain Fungal_trans_2 PF11951.3 EFX02427.1 - 1e-63 215.2 0.0 1e-63 215.2 0.0 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02427.1 - 2e-07 30.8 13.9 4.6e-07 29.6 9.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L13e PF01294.13 EFX02428.1 - 9.5e-64 214.1 0.9 1.2e-63 213.8 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e HPIP PF15226.1 EFX02428.1 - 0.064 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family Cyt-b5 PF00173.23 EFX02429.1 - 3.6e-12 45.9 0.0 4.8e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain S1 PF00575.18 EFX02430.1 - 4e-73 241.4 25.1 7.3e-11 42.0 0.0 12.6 12 0 0 12 12 12 12 S1 RNA binding domain TPR_14 PF13428.1 EFX02430.1 - 6.5e-06 26.3 0.0 1.8 9.4 0.0 5.3 3 1 2 5 5 5 2 Tetratricopeptide repeat Suf PF05843.9 EFX02430.1 - 2.1e-05 24.3 4.9 0.0015 18.3 1.4 3.6 1 1 1 2 2 2 1 Suppressor of forked protein (Suf) TPR_19 PF14559.1 EFX02430.1 - 7.8e-05 22.9 0.0 0.073 13.4 0.0 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat FAD_binding_6 PF00970.19 EFX02430.1 - 0.03 14.4 0.0 0.14 12.2 0.0 2.2 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain TPR_12 PF13424.1 EFX02430.1 - 0.33 10.9 2.2 6.6 6.7 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.11 EFX02432.1 - 5.4e-09 35.2 14.9 0.0001 21.1 1.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily FIST PF08495.5 EFX02432.1 - 0.032 13.3 0.0 0.061 12.4 0.0 1.4 1 0 0 1 1 1 0 FIST N domain Peptidase_A22B PF04258.8 EFX02434.1 - 3.4e-48 164.6 3.7 5.9e-47 160.5 2.5 2.5 1 1 0 1 1 1 1 Signal peptide peptidase FYVE PF01363.16 EFX02435.1 - 2.4e-17 62.5 9.4 2.3e-16 59.4 4.3 2.3 2 0 0 2 2 2 1 FYVE zinc finger Rbsn PF11464.3 EFX02435.1 - 0.00046 19.6 0.6 0.0012 18.4 0.4 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain C6_DPF PF10170.4 EFX02435.1 - 0.028 14.4 0.2 0.099 12.7 0.1 1.9 1 0 0 1 1 1 0 Cysteine-rich domain HypA PF01155.14 EFX02435.1 - 0.071 12.8 2.5 0.16 11.6 0.7 2.3 2 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Med9 PF07544.8 EFX02435.1 - 0.093 12.4 4.9 2.2 8.0 0.2 3.1 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Glyco_trans_1_3 PF13528.1 EFX02435.1 - 0.099 11.8 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 1 MAD PF05557.8 EFX02435.1 - 0.13 10.3 2.1 0.35 8.8 0.3 2.2 2 0 0 2 2 2 0 Mitotic checkpoint protein SlyX PF04102.7 EFX02435.1 - 0.76 10.1 3.9 25 5.3 0.0 3.2 3 0 0 3 3 3 0 SlyX zf-DHHC PF01529.15 EFX02435.1 - 2.7 7.3 5.4 1.9 7.8 1.2 2.3 3 0 0 3 3 3 0 DHHC palmitoyltransferase GFA PF04828.9 EFX02435.1 - 9.8 6.1 10.0 4.2 7.3 0.2 3.2 2 1 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme FTR PF01913.13 EFX02436.1 - 0.046 13.4 1.5 0.087 12.5 1.0 1.5 1 0 0 1 1 1 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase LigB PF02900.13 EFX02438.1 - 2.1e-49 167.9 0.0 2.6e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase NDK PF00334.14 EFX02439.1 - 5.3e-54 181.6 0.0 6e-54 181.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase SIR2 PF02146.12 EFX02440.1 - 1.4e-53 181.2 0.0 1.9e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Sir2 family zf-LYAR PF08790.6 EFX02440.1 - 0.027 14.1 0.2 0.062 13.0 0.1 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger ABC_tran PF00005.22 EFX02441.1 - 6.7e-48 162.4 0.0 2.4e-27 95.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFX02441.1 - 3.9e-32 111.7 13.9 2.3e-20 73.1 3.4 2.9 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 EFX02441.1 - 7.4e-10 38.4 6.0 0.01 15.0 0.7 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX02441.1 - 9.1e-10 38.9 0.4 0.034 14.1 0.0 4.2 4 0 0 4 4 4 2 AAA domain AAA_25 PF13481.1 EFX02441.1 - 2e-08 33.8 0.2 0.002 17.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX02441.1 - 1.5e-07 30.7 0.7 0.012 15.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 EFX02441.1 - 6.4e-06 25.7 1.1 0.027 13.9 0.0 2.9 3 0 0 3 3 3 2 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 EFX02441.1 - 4.4e-05 23.4 0.2 0.46 10.4 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.1 EFX02441.1 - 7.7e-05 23.1 0.3 0.069 13.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 EFX02441.1 - 0.00011 22.0 2.9 0.048 13.4 0.3 2.5 2 0 0 2 2 2 2 Domain of unknown function DUF87 Dynamin_N PF00350.18 EFX02441.1 - 0.0002 21.2 3.8 0.034 13.9 0.2 2.6 2 0 0 2 2 2 2 Dynamin family AAA_10 PF12846.2 EFX02441.1 - 0.00024 20.6 0.3 0.27 10.6 0.0 2.4 2 0 0 2 2 2 2 AAA-like domain DUF258 PF03193.11 EFX02441.1 - 0.00047 19.3 0.2 0.21 10.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFX02441.1 - 0.00054 20.7 4.5 0.66 10.8 0.1 3.5 3 0 0 3 3 3 2 AAA domain MobB PF03205.9 EFX02441.1 - 0.002 17.8 1.0 1.7 8.3 0.1 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 EFX02441.1 - 0.0036 17.7 0.2 3.1 8.3 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein ATP_bind_1 PF03029.12 EFX02441.1 - 0.01 15.3 1.9 12 5.3 0.1 3.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein SbcCD_C PF13558.1 EFX02441.1 - 0.015 15.1 0.0 4 7.4 0.0 3.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.13 EFX02441.1 - 0.026 14.0 0.0 1.2 8.5 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.1 EFX02441.1 - 0.031 14.5 2.4 7 6.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 EFX02441.1 - 0.06 12.8 0.5 13 5.1 0.0 2.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Pox_A32 PF04665.7 EFX02441.1 - 0.061 12.6 4.3 3.2 6.9 0.2 2.6 3 0 0 3 3 2 0 Poxvirus A32 protein AAA_33 PF13671.1 EFX02441.1 - 0.073 12.9 3.5 4.5 7.1 0.1 3.0 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 EFX02441.1 - 0.075 12.6 1.9 7 6.2 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.9 EFX02441.1 - 0.11 12.1 1.7 17 5.1 0.1 3.8 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 EFX02441.1 - 0.14 11.0 1.6 1.1 8.1 0.0 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_22 PF13401.1 EFX02441.1 - 0.17 12.0 6.2 4.7 7.3 0.2 3.6 2 2 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 EFX02441.1 - 0.18 11.1 1.7 12 5.3 0.0 3.3 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_24 PF13479.1 EFX02441.1 - 0.19 11.2 1.4 8.7 5.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EFX02441.1 - 0.32 11.1 1.7 53 4.0 0.1 3.6 3 0 0 3 3 3 0 RNA helicase AAA_16 PF13191.1 EFX02441.1 - 0.34 10.8 9.2 4.4 7.2 0.8 3.1 2 2 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 EFX02441.1 - 0.35 9.9 1.7 2 7.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.1 EFX02441.1 - 0.4 10.2 3.6 24 4.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.1 EFX02441.1 - 0.99 9.3 3.9 2.3 8.1 0.2 2.8 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFX02441.1 - 1.5 7.5 4.4 7.7 5.2 0.1 2.9 3 0 0 3 3 3 0 NB-ARC domain HALZ PF02183.13 EFX02442.1 - 0.00059 19.5 0.4 0.0014 18.2 0.3 1.6 2 0 0 2 2 2 1 Homeobox associated leucine zipper bZIP_1 PF00170.16 EFX02442.1 - 0.0045 16.9 4.4 0.0045 16.9 3.0 1.7 2 0 0 2 2 2 1 bZIP transcription factor Tropomyosin_1 PF12718.2 EFX02442.1 - 0.0047 16.7 5.1 0.0071 16.1 3.6 1.2 1 0 0 1 1 1 1 Tropomyosin like Macoilin PF09726.4 EFX02442.1 - 0.011 14.0 3.1 0.014 13.6 2.1 1.1 1 0 0 1 1 1 0 Transmembrane protein GAS PF13851.1 EFX02442.1 - 0.025 13.7 4.1 0.034 13.3 2.9 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 EFX02442.1 - 0.052 13.1 0.2 0.068 12.7 0.1 1.1 1 0 0 1 1 1 0 IncA protein BLOC1_2 PF10046.4 EFX02442.1 - 0.061 13.4 1.2 0.089 12.9 0.8 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.13 EFX02442.1 - 0.064 13.2 2.0 0.11 12.4 1.4 1.3 1 0 0 1 1 1 0 TSC-22/dip/bun family TMF_DNA_bd PF12329.3 EFX02442.1 - 0.085 12.6 6.6 0.15 11.9 4.6 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Med9 PF07544.8 EFX02442.1 - 0.095 12.4 2.8 0.16 11.7 1.8 1.4 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DivIC PF04977.10 EFX02442.1 - 0.32 10.4 3.2 0.63 9.5 2.0 1.6 1 1 0 1 1 1 0 Septum formation initiator DUF904 PF06005.7 EFX02442.1 - 0.34 11.2 5.4 0.8 10.0 3.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF904) bZIP_2 PF07716.10 EFX02442.1 - 0.96 9.3 7.5 27 4.6 3.9 2.5 2 1 0 2 2 2 0 Basic region leucine zipper CENP-H PF05837.7 EFX02442.1 - 2.5 8.3 7.8 3.8 7.7 5.4 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Glyco_hydro_31 PF01055.21 EFX02443.1 - 7.9e-154 512.7 1.3 1e-153 512.3 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EFX02443.1 - 1.2e-21 76.2 0.1 3.3e-21 74.8 0.1 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like Hemerythrin PF01814.18 EFX02444.1 - 5.6e-12 45.9 2.3 8.5e-12 45.3 1.6 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain EF-hand_9 PF14658.1 EFX02444.1 - 0.053 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain DNA_ligase_A_N PF04675.9 EFX02445.1 - 3.6e-12 46.4 0.0 1.3e-11 44.5 0.0 1.9 1 1 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_M PF01068.16 EFX02445.1 - 1.5e-09 37.5 0.1 1.4e-05 24.5 0.1 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Dynactin_p62 PF05502.8 EFX02446.1 - 2.2e-163 544.5 0.0 2.8e-163 544.1 0.0 1.1 1 0 0 1 1 1 1 Dynactin p62 family TauD PF02668.11 EFX02447.1 - 1.5e-29 103.4 0.1 2e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 EFX02447.1 - 0.046 12.6 0.0 0.076 11.8 0.0 1.3 1 0 0 1 1 1 0 CsiD Peptidase_S3 PF00944.14 EFX02447.1 - 0.15 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Alphavirus core protein DUF3455 PF11937.3 EFX02448.1 - 1e-28 100.4 0.0 1.5e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Amino_oxidase PF01593.19 EFX02450.1 - 0.0045 16.1 0.0 0.0065 15.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase ATP-synt_10 PF05176.9 EFX02451.1 - 3.8e-25 88.6 0.0 4.7e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein Fungal_trans PF04082.13 EFX02452.1 - 3.9e-31 107.8 0.0 6.1e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain IBR PF01485.16 EFX02452.1 - 2e-09 37.1 16.3 3.7e-06 26.7 2.4 3.7 3 0 0 3 3 3 2 IBR domain Zn_clus PF00172.13 EFX02452.1 - 0.00012 21.8 0.4 0.00012 21.8 0.3 2.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF997 PF06196.7 EFX02452.1 - 0.16 11.4 0.0 0.41 10.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF997) Prok-RING_4 PF14447.1 EFX02452.1 - 5.5 6.6 19.5 0.14 11.7 4.7 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 GST_N_3 PF13417.1 EFX02453.1 - 8.5e-09 35.5 0.3 1.7e-08 34.5 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFX02453.1 - 1.1e-07 31.6 1.2 2.8e-07 30.3 0.8 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFX02453.1 - 7.7e-05 23.1 0.0 0.00013 22.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFX02453.1 - 0.033 14.1 0.0 0.076 13.0 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFX02453.1 - 0.073 13.0 0.0 0.2 11.6 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sec3_C PF09763.4 EFX02454.1 - 2.9e-221 736.4 0.0 3.8e-221 735.9 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 EFX02454.1 - 4.1e-31 106.6 0.2 7e-31 105.9 0.1 1.4 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.1 EFX02454.1 - 0.0006 19.8 2.4 0.0055 16.8 0.1 2.8 3 0 0 3 3 3 1 Sec3 exocyst complex subunit Vps52 PF04129.7 EFX02454.1 - 0.13 10.8 2.3 0.51 8.8 0.1 2.6 3 0 0 3 3 3 0 Vps52 / Sac2 family Ras PF00071.17 EFX02455.1 - 1.6e-12 47.1 0.0 7.3e-05 22.2 0.0 3.6 3 1 0 3 3 3 3 Ras family Miro PF08477.8 EFX02455.1 - 1.4e-06 28.8 0.0 1.7e-05 25.2 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 EFX02455.1 - 0.00036 20.5 0.3 0.001 19.1 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.16 EFX02455.1 - 0.0023 17.1 0.0 0.0049 16.0 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA PF00004.24 EFX02455.1 - 0.0051 17.0 0.0 0.0097 16.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX02455.1 - 0.01 15.5 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFX02455.1 - 0.016 15.3 0.1 0.056 13.5 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 EFX02455.1 - 0.029 14.2 4.1 3.2 7.6 0.0 3.3 2 2 0 3 3 3 0 AAA domain NACHT PF05729.7 EFX02455.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 EFX02455.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 EFX02455.1 - 0.15 11.9 0.0 0.48 10.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain V-SNARE_C PF12352.3 EFX02457.1 - 3.7e-05 23.6 3.0 3.7e-05 23.6 2.1 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus SNARE PF05739.14 EFX02457.1 - 0.097 12.3 0.1 0.097 12.3 0.1 3.2 3 0 0 3 3 3 0 SNARE domain RhoGAP PF00620.22 EFX02458.1 - 5.7e-36 123.4 0.0 1.5e-35 122.0 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 EFX02458.1 - 8.8e-30 102.5 39.9 4.5e-12 45.8 5.1 4.9 5 0 0 5 5 5 4 LIM domain PfkB PF00294.19 EFX02459.1 - 1.3e-10 40.9 0.1 5.4e-10 38.8 0.0 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EFX02459.1 - 1.4e-10 40.8 0.0 3.1e-10 39.6 0.0 1.5 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Alb1 PF09135.6 EFX02460.1 - 3.5e-22 79.1 11.2 4.7e-22 78.7 7.8 1.2 1 0 0 1 1 1 1 Alb1 Fungal_trans PF04082.13 EFX02461.1 - 3.1e-21 75.4 0.0 8.9e-21 73.9 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02461.1 - 1.6e-07 31.1 7.6 1.6e-07 31.1 5.3 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PDR_CDR PF06422.7 EFX02461.1 - 0.039 13.6 0.1 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 CDR ABC transporter 3HCDH_N PF02737.13 EFX02462.1 - 5.2e-19 68.6 0.0 1.3e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 EFX02462.1 - 7.9e-12 45.4 0.0 1.8e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DUF676 PF05057.9 EFX02462.1 - 4.3e-06 26.1 0.0 9e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 EFX02462.1 - 4e-05 23.5 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX02462.1 - 4.5e-05 23.1 0.1 0.00017 21.2 0.1 1.9 1 1 0 1 1 1 1 PGAP1-like protein WD40 PF00400.27 EFX02462.1 - 5.4e-05 22.9 1.8 0.15 12.0 0.0 4.8 4 0 0 4 4 4 1 WD domain, G-beta repeat NACHT PF05729.7 EFX02462.1 - 0.00018 21.1 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Abhydrolase_5 PF12695.2 EFX02462.1 - 0.017 14.8 0.0 0.061 13.0 0.0 1.9 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_2 PF01674.13 EFX02462.1 - 0.17 11.1 0.0 0.84 8.8 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 2) EF1_GNE PF00736.14 EFX02463.1 - 5.4e-30 102.9 1.6 9.6e-30 102.1 1.1 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 EFX02463.1 - 7.1e-14 51.6 9.2 7.1e-14 51.6 6.4 2.4 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.1 EFX02463.1 - 0.003 17.9 0.2 0.0076 16.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFX02463.1 - 0.016 15.1 0.0 0.055 13.4 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Vezatin PF12632.2 EFX02464.1 - 5e-54 183.0 0.0 7.9e-54 182.3 0.0 1.3 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes Fructosamin_kin PF03881.9 EFX02465.1 - 8.6e-36 123.3 0.3 1.1e-35 123.0 0.2 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 EFX02465.1 - 0.0034 17.1 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family GTP_EFTU PF00009.22 EFX02466.1 - 1.2e-08 34.5 0.0 1.9e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain T2SE PF00437.15 EFX02466.1 - 0.00022 20.2 0.4 0.00037 19.4 0.3 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.22 EFX02466.1 - 0.0026 18.0 0.1 0.0056 16.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 EFX02466.1 - 0.0048 16.4 2.6 0.011 15.2 1.8 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ArgK PF03308.11 EFX02466.1 - 0.011 14.5 1.7 0.02 13.7 0.5 1.8 2 0 0 2 2 2 0 ArgK protein ATP_bind_1 PF03029.12 EFX02466.1 - 0.021 14.3 0.9 3.9 6.9 0.2 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.1 EFX02466.1 - 0.025 14.8 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.4 EFX02466.1 - 0.079 11.8 0.2 0.13 11.1 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_17 PF13207.1 EFX02466.1 - 0.11 13.2 0.0 0.22 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EFX02466.1 - 0.11 11.6 0.8 0.2 10.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 EFX02466.1 - 0.28 11.4 0.2 0.5 10.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain PI-PLC-X PF00388.14 EFX02467.1 - 0.043 13.2 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Arf PF00025.16 EFX02468.1 - 3.7e-79 263.9 0.1 4.4e-79 263.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFX02468.1 - 4.9e-14 51.9 0.0 6.1e-14 51.6 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EFX02468.1 - 2.5e-13 49.7 0.0 2.8e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EFX02468.1 - 4.2e-12 45.4 1.7 4.5e-09 35.4 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EFX02468.1 - 4.9e-11 42.2 0.0 5.9e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EFX02468.1 - 1.1e-08 35.5 0.0 1.6e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EFX02468.1 - 2.6e-06 27.3 0.0 3.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 EFX02468.1 - 0.0071 15.4 0.3 0.02 13.9 0.0 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.22 EFX02468.1 - 0.011 15.1 0.1 0.12 11.8 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 EFX02468.1 - 0.088 12.6 0.1 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain zf-C2H2_4 PF13894.1 EFX02469.1 - 1.3e-08 34.5 28.2 0.0064 16.7 0.5 6.9 5 1 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX02469.1 - 6.3e-07 29.3 10.9 2.3e-06 27.6 1.5 5.3 4 1 1 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFX02469.1 - 4.9e-05 23.4 1.7 4.9e-05 23.4 1.2 7.8 9 1 0 9 9 9 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EFX02469.1 - 0.016 15.0 0.3 0.016 15.0 0.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFX02469.1 - 0.18 11.9 0.1 0.18 11.9 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Gpi16 PF04113.9 EFX02470.1 - 1.9e-239 795.3 0.0 2.5e-239 795.0 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component SKG6 PF08693.5 EFX02471.1 - 0.025 13.8 0.0 0.025 13.8 0.0 2.5 3 0 0 3 3 3 0 Transmembrane alpha-helix domain GFO_IDH_MocA PF01408.17 EFX02472.1 - 4.6e-10 40.0 0.7 1.5e-09 38.4 0.5 2.0 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.11 EFX02472.1 - 0.028 14.7 0.1 0.084 13.2 0.1 1.9 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain CoA_binding_2 PF13380.1 EFX02472.1 - 0.11 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 CoA binding domain XPA_N PF01286.13 EFX02472.1 - 0.21 11.2 0.7 0.4 10.3 0.5 1.4 1 0 0 1 1 1 0 XPA protein N-terminal dUTPase PF00692.14 EFX02473.1 - 2.4e-39 133.7 0.0 3.2e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 dUTPase Cgr1 PF03879.9 EFX02474.1 - 4e-36 123.4 26.4 4.8e-36 123.2 18.3 1.0 1 0 0 1 1 1 1 Cgr1 family PRP1_N PF06424.7 EFX02474.1 - 0.011 16.0 9.2 0.015 15.6 6.4 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal CAF-1_p150 PF11600.3 EFX02474.1 - 0.059 12.7 23.3 0.07 12.4 16.2 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PLDc_2 PF13091.1 EFX02474.1 - 0.26 11.0 2.6 0.32 10.7 1.8 1.2 1 0 0 1 1 1 0 PLD-like domain RR_TM4-6 PF06459.7 EFX02474.1 - 3.5 7.4 11.5 4.1 7.2 8.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop16 PF09420.5 EFX02475.1 - 2.2e-36 125.4 0.8 2.2e-36 125.4 0.5 1.7 2 0 0 2 2 2 1 Ribosome biogenesis protein Nop16 Apc3 PF12895.2 EFX02475.1 - 3.7e-24 84.6 11.1 4.9e-21 74.6 0.7 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 EFX02475.1 - 6.4e-24 83.3 0.7 5.7e-08 32.3 0.0 7.7 5 2 4 9 9 9 7 TPR repeat TPR_1 PF00515.23 EFX02475.1 - 3.5e-23 80.1 2.6 0.0065 16.0 0.0 9.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02475.1 - 6.3e-23 78.7 21.5 0.0057 16.4 0.0 11.2 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_19 PF14559.1 EFX02475.1 - 1.8e-22 79.4 12.8 1.2e-05 25.5 0.1 8.5 6 2 1 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02475.1 - 7e-16 57.9 25.8 4e-07 29.8 0.0 8.6 6 2 1 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.1 EFX02475.1 - 4.7e-12 46.2 46.7 5.9e-06 26.8 0.0 9.4 8 2 4 12 12 10 7 Tetratricopeptide repeat TPR_14 PF13428.1 EFX02475.1 - 3.2e-09 36.6 46.2 0.043 14.4 0.0 12.4 7 3 7 14 14 12 4 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02475.1 - 1.3e-08 34.0 0.0 11 6.1 0.0 7.7 8 1 1 9 9 8 0 Tetratricopeptide repeat TPR_7 PF13176.1 EFX02475.1 - 2.8e-08 32.9 9.5 1.3 9.0 0.0 8.4 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_10 PF13374.1 EFX02475.1 - 4.5e-07 29.5 28.2 0.027 14.4 0.1 8.1 9 1 0 9 9 6 5 Tetratricopeptide repeat Coatomer_E PF04733.9 EFX02475.1 - 7.2e-05 22.1 0.0 1.4 8.0 0.0 3.7 2 1 1 3 3 3 2 Coatomer epsilon subunit TPR_17 PF13431.1 EFX02475.1 - 0.00069 19.6 1.4 21 5.6 0.0 7.4 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_9 PF13371.1 EFX02475.1 - 0.0024 17.6 10.8 0.13 12.1 0.1 5.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX02475.1 - 0.029 14.8 12.8 14 6.3 0.1 8.1 9 0 0 9 9 7 0 Tetratricopeptide repeat Dpy-30 PF05186.8 EFX02475.1 - 0.89 9.0 4.1 5.7 6.5 0.0 3.8 4 0 0 4 4 4 0 Dpy-30 motif Spt5_N PF11942.3 EFX02475.1 - 1.1 9.8 17.1 2.6 8.6 1.1 2.9 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal SGT1 PF07093.6 EFX02475.1 - 2.2 6.5 11.1 3.2 6.0 6.4 1.9 2 0 0 2 2 2 0 SGT1 protein TPR_4 PF07721.9 EFX02475.1 - 5 7.8 0.0 2.6 8.7 0.0 9.1 10 0 0 10 10 6 0 Tetratricopeptide repeat Proteasom_Rpn13 PF04683.8 EFX02476.1 - 8.4e-24 83.4 0.0 1.3e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor CobT PF06213.7 EFX02476.1 - 0.22 10.6 6.8 0.41 9.7 4.7 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT GRP PF07172.6 EFX02479.1 - 0.02 15.3 1.0 0.02 15.3 0.7 2.8 3 0 0 3 3 3 0 Glycine rich protein family Protocadherin PF08374.6 EFX02479.1 - 0.021 14.4 0.0 0.047 13.3 0.0 1.5 1 0 0 1 1 1 0 Protocadherin DUF3357 PF11837.3 EFX02479.1 - 0.1 12.4 4.0 0.79 9.5 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) DUF4235 PF14019.1 EFX02479.1 - 4.5 7.1 8.7 0.083 12.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) DAO PF01266.19 EFX02480.1 - 1.3e-44 152.5 19.0 3.3e-43 147.9 13.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX02480.1 - 0.00025 21.0 0.3 0.00071 19.5 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFX02480.1 - 0.00046 20.5 0.1 1.8 9.0 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX02480.1 - 0.12 10.9 0.7 2.3 6.7 0.1 2.2 2 0 0 2 2 2 0 Tryptophan halogenase DUF1856 PF08983.5 EFX02481.1 - 0.12 12.4 0.4 1.4 9.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1856) RRM_1 PF00076.17 EFX02483.1 - 9.2e-12 44.4 0.1 7.2e-05 22.3 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX02483.1 - 3.9e-11 42.7 0.2 3.9e-06 26.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX02483.1 - 0.00029 20.6 0.1 0.00092 19.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) p450 PF00067.17 EFX02484.1 - 6.1e-60 203.0 0.0 7.8e-58 196.1 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 Apidaecin PF00807.12 EFX02484.1 - 0.038 13.6 0.2 0.087 12.5 0.1 1.5 1 0 0 1 1 1 0 Apidaecin Med7 PF05983.6 EFX02485.1 - 1.2e-10 41.4 1.0 3.1e-10 40.0 1.0 1.5 2 0 0 2 2 2 1 MED7 protein Rox3 PF08633.5 EFX02486.1 - 4.1e-43 147.9 0.2 8.6e-43 146.8 0.0 1.6 2 0 0 2 2 2 1 Rox3 mediator complex subunit GSHPx PF00255.14 EFX02487.1 - 1.7e-39 133.4 0.0 2.2e-39 133.1 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 EFX02487.1 - 0.00014 21.4 0.0 0.00022 20.8 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFX02487.1 - 0.00048 19.6 0.1 0.00054 19.5 0.0 1.3 1 1 0 1 1 1 1 Redoxin DUF4174 PF13778.1 EFX02487.1 - 0.027 14.5 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) AAA_17 PF13207.1 EFX02488.1 - 5e-11 43.4 0.0 6.8e-11 43.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain SKI PF01202.17 EFX02488.1 - 7.9e-10 38.8 0.0 9.3e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.1 EFX02488.1 - 8.5e-10 38.6 0.0 1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX02488.1 - 1e-09 38.7 0.0 1.9e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EFX02488.1 - 5e-05 23.5 0.1 7.5e-05 22.9 0.1 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX02488.1 - 9.6e-05 22.5 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX02488.1 - 0.00083 19.0 0.1 0.0018 17.9 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 EFX02488.1 - 0.00091 18.9 0.0 0.0021 17.7 0.0 1.6 1 1 1 2 2 2 1 NACHT domain Mg_chelatase PF01078.16 EFX02488.1 - 0.0013 17.9 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 EFX02488.1 - 0.0017 17.6 0.1 0.0028 16.8 0.1 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.1 EFX02488.1 - 0.0018 17.6 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EFX02488.1 - 0.0025 17.7 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX02488.1 - 0.0028 17.6 0.0 0.0067 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 EFX02488.1 - 0.0066 16.3 0.0 0.021 14.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFX02488.1 - 0.0068 15.4 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF2075 PF09848.4 EFX02488.1 - 0.011 14.7 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T2SE PF00437.15 EFX02488.1 - 0.019 13.8 0.1 0.03 13.2 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.1 EFX02488.1 - 0.024 14.2 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EFX02488.1 - 0.028 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFX02488.1 - 0.039 14.1 0.0 0.07 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase CPT PF07931.7 EFX02488.1 - 0.042 13.4 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.10 EFX02488.1 - 0.043 13.5 0.1 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.1 EFX02488.1 - 0.049 13.1 0.3 0.1 12.1 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.1 EFX02488.1 - 0.053 13.4 0.0 1.4 8.7 0.0 2.2 1 1 0 1 1 1 0 Cytidylate kinase-like family AAA_5 PF07728.9 EFX02488.1 - 0.055 13.1 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 EFX02488.1 - 0.06 12.7 0.1 0.099 12.0 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Rad17 PF03215.10 EFX02488.1 - 0.061 12.0 0.0 0.085 11.5 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein APS_kinase PF01583.15 EFX02488.1 - 0.062 12.9 0.0 0.083 12.5 0.0 1.3 1 1 0 1 1 1 0 Adenylylsulphate kinase MobB PF03205.9 EFX02488.1 - 0.074 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 EFX02488.1 - 0.079 13.2 0.0 0.095 12.9 0.0 1.3 1 1 0 1 1 1 0 ABC transporter KaiC PF06745.8 EFX02488.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.1 EFX02488.1 - 0.16 12.2 0.2 0.23 11.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 EFX02488.1 - 0.17 11.3 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DHDPS PF00701.17 EFX02489.1 - 4e-32 110.9 0.0 5.2e-32 110.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family FAT PF02259.18 EFX02490.1 - 1.2e-71 241.5 1.0 3.5e-71 240.0 0.7 1.9 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 EFX02490.1 - 1.9e-25 89.7 0.0 1.1e-24 87.1 0.0 2.4 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 EFX02490.1 - 8.7e-08 31.4 0.1 3.9e-07 29.3 0.1 2.2 2 0 0 2 2 2 1 FATC domain Microtub_assoc PF07989.6 EFX02492.1 - 1.6e-18 66.2 8.1 1.6e-18 66.2 5.6 7.2 6 1 2 8 8 8 1 Microtubule associated Reo_sigmaC PF04582.7 EFX02492.1 - 0.16 11.1 37.4 0.011 14.8 2.1 5.6 3 1 2 6 6 6 0 Reovirus sigma C capsid protein Cad PF03596.8 EFX02493.1 - 8.2e-29 100.6 0.0 1.4e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 Cadmium resistance transporter V-SNARE_C PF12352.3 EFX02494.1 - 1.8e-13 50.3 0.1 1.8e-13 50.3 0.1 2.9 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Het-C PF07217.6 EFX02494.1 - 0.015 13.5 0.3 0.041 12.1 0.1 1.6 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C HemX PF04375.9 EFX02494.1 - 0.016 13.8 6.9 0.032 12.8 4.8 1.7 1 1 0 1 1 1 0 HemX AAA_13 PF13166.1 EFX02494.1 - 0.024 13.1 1.5 0.029 12.8 1.0 1.2 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 EFX02494.1 - 0.048 13.2 10.5 0.075 12.6 7.3 1.3 1 0 0 1 1 1 0 IncA protein FTCD_C PF04961.7 EFX02494.1 - 0.053 12.9 1.7 2 7.8 0.1 2.3 1 1 2 3 3 3 0 Formiminotransferase-cyclodeaminase Reo_sigmaC PF04582.7 EFX02494.1 - 0.089 11.9 0.6 0.15 11.2 0.4 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein G-alpha PF00503.15 EFX02494.1 - 0.11 11.1 0.5 0.11 11.0 0.3 1.1 1 0 0 1 1 1 0 G-protein alpha subunit YscO PF07321.7 EFX02494.1 - 0.15 11.9 10.6 0.88 9.3 2.5 2.2 2 0 0 2 2 2 0 Type III secretion protein YscO Syntaxin_2 PF14523.1 EFX02494.1 - 0.21 11.6 8.3 0.99 9.4 5.7 2.1 1 1 1 2 2 2 0 Syntaxin-like protein APG6 PF04111.7 EFX02494.1 - 0.31 10.0 6.1 0.46 9.4 4.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 P16-Arc PF04699.9 EFX02494.1 - 0.46 10.4 2.4 0.83 9.6 1.1 1.8 1 1 1 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) UPF0184 PF03670.8 EFX02494.1 - 0.51 10.5 3.1 19 5.5 0.2 2.8 3 0 0 3 3 2 0 Uncharacterised protein family (UPF0184) AAA_27 PF13514.1 EFX02494.1 - 0.51 7.9 12.3 0.45 8.1 7.2 1.5 1 1 1 2 2 2 0 AAA domain DUF948 PF06103.6 EFX02494.1 - 0.62 9.9 3.3 8.6 6.3 0.0 3.5 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.5 EFX02494.1 - 0.63 10.1 6.0 2.3 8.3 4.2 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Uds1 PF15456.1 EFX02494.1 - 1.1 9.3 13.1 2.8 7.9 1.2 2.6 1 1 1 2 2 2 0 Up-regulated During Septation DUF972 PF06156.8 EFX02494.1 - 1.2 9.4 5.8 28 5.1 4.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) PilO PF04350.8 EFX02494.1 - 1.3 8.8 7.5 0.37 10.6 0.5 2.8 2 1 2 4 4 4 0 Pilus assembly protein, PilO FUSC PF04632.7 EFX02494.1 - 2 6.7 8.6 2.5 6.4 6.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4201 PF13870.1 EFX02494.1 - 2.1 7.7 9.4 12 5.2 6.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Atg14 PF10186.4 EFX02494.1 - 2.2 7.1 13.2 2.2 7.1 3.7 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 EFX02494.1 - 2.3 6.7 7.9 5.5 5.5 5.5 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein YlqD PF11068.3 EFX02494.1 - 4.5 7.3 8.0 1.5 8.8 3.0 1.9 1 1 1 2 2 2 0 YlqD protein GAS PF13851.1 EFX02494.1 - 7.2 5.7 10.8 18 4.4 0.4 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Mnd1 PF03962.10 EFX02494.1 - 9.5 5.8 9.0 9.1 5.8 3.1 2.1 1 1 1 2 2 2 0 Mnd1 family AAA_2 PF07724.9 EFX02496.1 - 9e-43 146.1 0.0 1.4e-41 142.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 EFX02496.1 - 3.3e-23 81.3 0.0 9.7e-23 79.8 0.0 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 EFX02496.1 - 3.9e-19 69.1 0.0 2.8e-10 40.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX02496.1 - 1.1e-12 47.8 0.0 7e-09 35.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFX02496.1 - 4.5e-12 46.3 9.0 0.00036 20.5 0.0 5.0 4 2 1 6 6 5 3 AAA ATPase domain AAA_22 PF13401.1 EFX02496.1 - 2.4e-09 37.4 0.4 0.0042 17.2 0.0 3.5 3 2 0 3 3 3 2 AAA domain Sigma54_activat PF00158.21 EFX02496.1 - 8.9e-09 35.0 0.2 0.00031 20.2 0.0 2.5 2 1 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.7 EFX02496.1 - 1.3e-05 24.8 0.0 0.13 11.8 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_14 PF13173.1 EFX02496.1 - 1.4e-05 25.0 0.0 0.097 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EFX02496.1 - 1.7e-05 25.5 4.5 0.0055 17.5 0.1 4.0 3 1 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 EFX02496.1 - 5.7e-05 22.9 6.1 1.1 8.9 0.0 4.3 3 2 1 4 4 3 2 Archaeal ATPase AAA_18 PF13238.1 EFX02496.1 - 6.1e-05 23.3 5.3 0.073 13.3 0.0 3.7 4 0 0 4 4 4 2 AAA domain AAA_19 PF13245.1 EFX02496.1 - 0.00012 21.7 0.0 0.072 12.8 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 EFX02496.1 - 0.00039 19.8 0.0 0.7 9.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.1 EFX02496.1 - 0.00055 19.3 0.4 0.55 9.5 0.0 2.9 2 2 0 2 2 2 1 AAA domain ABC_tran PF00005.22 EFX02496.1 - 0.0012 19.1 0.7 0.95 9.7 0.0 3.4 3 0 0 3 3 3 1 ABC transporter MobB PF03205.9 EFX02496.1 - 0.0017 18.0 0.0 0.14 11.9 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 EFX02496.1 - 0.0019 18.3 0.0 0.37 10.9 0.0 2.8 2 1 0 2 2 2 1 RNA helicase AAA_28 PF13521.1 EFX02496.1 - 0.0036 17.2 0.5 4.5 7.2 0.0 3.3 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.17 EFX02496.1 - 0.0038 16.6 0.0 0.14 11.5 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PhoH PF02562.11 EFX02496.1 - 0.0042 16.3 0.1 0.28 10.3 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.16 EFX02496.1 - 0.0065 15.6 0.3 3.1 6.9 0.0 3.0 2 2 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 EFX02496.1 - 0.009 15.6 0.2 1.1 8.8 0.0 3.7 4 0 0 4 4 4 1 AAA domain DUF258 PF03193.11 EFX02496.1 - 0.012 14.8 0.0 3.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF815 PF05673.8 EFX02496.1 - 0.022 13.6 0.2 0.91 8.3 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF815) AAA_10 PF12846.2 EFX02496.1 - 0.024 14.0 1.0 0.63 9.4 0.0 3.5 3 2 0 3 3 3 0 AAA-like domain ResIII PF04851.10 EFX02496.1 - 0.025 14.4 2.9 3.5 7.4 0.0 3.7 3 2 1 4 4 4 0 Type III restriction enzyme, res subunit Miro PF08477.8 EFX02496.1 - 0.025 15.0 0.0 0.79 10.2 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein AAA_24 PF13479.1 EFX02496.1 - 0.061 12.9 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EFX02496.1 - 0.075 12.5 0.0 2.1 7.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 EFX02496.1 - 0.078 12.5 0.0 4 7.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain PIF1 PF05970.9 EFX02496.1 - 0.081 11.8 0.0 2.4 7.0 0.0 2.4 3 0 0 3 3 2 0 PIF1-like helicase UvrD-helicase PF00580.16 EFX02496.1 - 0.087 12.1 3.5 0.3 10.3 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain UPF0079 PF02367.12 EFX02496.1 - 0.088 12.4 0.0 19 4.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ATP_bind_1 PF03029.12 EFX02496.1 - 0.1 12.1 0.0 0.68 9.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein OEP PF02321.13 EFX02496.1 - 0.81 9.2 10.8 1.8 8.1 7.5 1.5 1 0 0 1 1 1 0 Outer membrane efflux protein APG6 PF04111.7 EFX02496.1 - 1.2 8.1 5.9 1.9 7.4 4.1 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 EFX02496.1 - 1.9 8.0 11.3 4.8 6.7 7.8 1.7 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.4 EFX02496.1 - 2.3 7.0 8.7 3.9 6.3 6.0 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_23 PF13476.1 EFX02496.1 - 9.8 6.4 18.1 1.3e+02 2.7 0.0 3.2 2 1 0 2 2 2 0 AAA domain EMP24_GP25L PF01105.19 EFX02497.1 - 5.1e-47 159.9 0.0 5.9e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Dioxygenase_C PF00775.16 EFX02497.1 - 0.026 13.8 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Dioxygenase Sulfate_transp PF00916.15 EFX02498.1 - 1.3e-35 122.7 1.1 3.4e-35 121.4 0.7 1.7 1 0 0 1 1 1 1 Sulfate transporter family cNMP_binding PF00027.24 EFX02498.1 - 3.1e-15 55.7 0.0 5.9e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.16 EFX02498.1 - 4.8e-11 42.1 0.4 1e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 STAS domain Glyco_hydro_3 PF00933.16 EFX02499.1 - 1.9e-58 197.7 0.1 2.6e-45 154.7 0.1 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX02499.1 - 3e-31 108.7 0.1 2.2e-27 96.0 0.0 2.7 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX02499.1 - 8e-20 70.5 0.1 2.5e-19 68.9 0.1 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.7 EFX02499.1 - 9.7e-10 38.2 0.0 1.8e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 PA14 domain SpoU_methylase PF00588.14 EFX02500.1 - 1.1e-25 90.1 0.0 1.7e-25 89.5 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 EFX02500.1 - 3.4e-07 30.3 0.0 7.8e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Homeobox PF00046.24 EFX02501.1 - 2.4e-13 49.4 0.3 2.4e-13 49.4 0.2 2.3 3 0 0 3 3 3 1 Homeobox domain Homeobox_KN PF05920.6 EFX02501.1 - 0.02 14.6 0.7 0.53 10.0 0.0 2.6 2 0 0 2 2 2 0 Homeobox KN domain AIG2 PF06094.7 EFX02502.1 - 4.4e-14 52.8 0.0 6.6e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 AIG2-like family Complex1_30kDa PF00329.14 EFX02502.1 - 0.033 14.4 0.1 0.049 13.8 0.0 1.2 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit HD_3 PF13023.1 EFX02503.1 - 1.5e-38 132.1 0.0 1.9e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 HD domain EF-hand_1 PF00036.27 EFX02503.1 - 0.025 13.8 0.0 0.081 12.2 0.0 2.0 1 0 0 1 1 1 0 EF hand HD PF01966.17 EFX02503.1 - 0.029 14.3 0.0 0.081 12.9 0.0 1.8 1 1 0 1 1 1 0 HD domain EF-hand_7 PF13499.1 EFX02503.1 - 0.1 12.7 0.1 0.22 11.6 0.1 1.7 1 1 0 1 1 1 0 EF-hand domain pair Kinesin PF00225.18 EFX02504.1 - 1.1e-96 323.4 0.1 1.7e-96 322.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain BAR_2 PF10455.4 EFX02504.1 - 0.026 13.4 0.8 0.065 12.1 0.5 1.6 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking PCNA_N PF00705.13 EFX02505.1 - 9.4e-55 183.5 4.8 9.4e-55 183.5 3.4 1.5 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 EFX02505.1 - 2.5e-49 166.4 0.2 5.4e-49 165.3 0.0 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 EFX02505.1 - 8.6e-12 44.7 0.3 1e-11 44.4 0.2 1.0 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.7 EFX02505.1 - 2.4e-07 29.9 0.3 0.0017 17.3 0.1 2.1 2 0 0 2 2 2 2 Hus1-like protein Rad1 PF02144.11 EFX02505.1 - 2.6e-07 29.6 2.7 1.8e-05 23.6 1.9 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Borrelia_lipo_2 PF06238.6 EFX02505.1 - 0.12 12.4 0.5 1.2 9.2 0.1 2.5 3 0 0 3 3 3 0 Borrelia burgdorferi BBR25 lipoprotein DUF3074 PF11274.3 EFX02506.1 - 3.1e-37 128.0 0.0 4e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Dynamin_N PF00350.18 EFX02507.1 - 3.7e-20 72.4 0.0 1.2e-19 70.7 0.0 1.9 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFX02507.1 - 1.9e-07 30.1 0.0 0.0036 16.1 0.0 2.5 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.18 EFX02507.1 - 0.053 13.4 0.0 8.8 6.3 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Ribosomal_L6e PF01159.14 EFX02508.1 - 4.1e-38 129.9 0.9 7.2e-38 129.1 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e UCH PF00443.24 EFX02509.1 - 7.3e-27 94.1 0.0 5.6e-19 68.2 0.0 2.3 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX02509.1 - 0.00027 20.4 0.0 0.57 9.5 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MFS_1 PF07690.11 EFX02510.1 - 1.3e-40 139.1 53.4 1.3e-40 139.1 37.0 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02510.1 - 3.5e-14 52.2 10.3 3.5e-14 52.2 7.1 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.15 EFX02510.1 - 0.031 12.3 4.3 0.049 11.6 0.3 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SPDY PF03771.11 EFX02510.1 - 0.042 13.3 0.1 0.1 12.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF317) adh_short PF00106.20 EFX02511.1 - 8e-23 81.1 0.0 1.1e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX02511.1 - 5.6e-12 45.9 0.0 7.8e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX02511.1 - 2.5e-08 33.7 0.0 4.3e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFX02511.1 - 0.00022 21.2 0.1 0.00051 20.1 0.1 1.7 1 1 0 1 1 1 1 NADH(P)-binding DUF3798 PF12683.2 EFX02511.1 - 0.0018 17.4 0.1 0.0023 17.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) Polysacc_synt_2 PF02719.10 EFX02511.1 - 0.002 17.1 0.0 0.0025 16.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 EFX02511.1 - 0.0096 16.0 0.0 0.019 15.0 0.0 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 EFX02511.1 - 0.025 13.5 0.1 0.043 12.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_2 PF03446.10 EFX02511.1 - 0.076 12.8 0.1 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EFX02511.1 - 0.077 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NmrA PF05368.8 EFX02511.1 - 0.089 12.0 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family UPF0029 PF01205.14 EFX02512.1 - 1.5e-27 95.4 0.0 2.4e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 EFX02512.1 - 4.1e-05 23.4 0.0 8.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 RWD domain Fungal_trans PF04082.13 EFX02513.1 - 6.9e-27 93.9 0.0 1.2e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02513.1 - 3.2e-09 36.5 13.2 5.5e-09 35.7 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain efThoc1 PF11957.3 EFX02513.1 - 0.19 10.1 0.0 0.4 9.1 0.0 1.4 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor HMG_box_2 PF09011.5 EFX02514.1 - 5.8e-07 29.7 2.3 3.9e-05 23.9 0.8 2.8 2 0 0 2 2 2 1 HMG-box domain HMG_box PF00505.14 EFX02514.1 - 2.2e-06 27.8 1.1 2.2e-06 27.8 0.8 3.4 4 1 0 4 4 4 1 HMG (high mobility group) box HC2 PF07382.6 EFX02514.1 - 0.0036 17.1 37.7 0.0036 17.1 26.1 2.3 3 0 0 3 3 3 1 Histone H1-like nucleoprotein HC2 Fungal_trans_2 PF11951.3 EFX02515.1 - 1.4e-52 178.6 2.9 4e-52 177.0 2.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02515.1 - 3.4e-07 30.0 7.3 7.4e-07 28.9 5.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAT1 PF09770.4 EFX02515.1 - 0.083 11.1 14.9 0.12 10.5 10.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.8 EFX02515.1 - 1.5 7.5 23.9 1.7 7.4 14.6 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor zf-PHD-like PF15446.1 EFX02516.1 - 3.4e-70 234.8 8.2 7.3e-70 233.7 5.7 1.6 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.18 EFX02516.1 - 1.5e-50 171.7 0.0 2.1e-50 171.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX02516.1 - 1.1e-13 50.8 0.0 2.9e-13 49.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EFX02516.1 - 2.6e-09 36.3 0.8 5.7e-09 35.2 0.6 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Chromo PF00385.19 EFX02516.1 - 0.00015 21.3 0.4 0.00045 19.8 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.24 EFX02516.1 - 0.00046 19.8 2.6 0.00046 19.8 1.8 3.3 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.1 EFX02516.1 - 0.002 17.4 12.3 0.0042 16.3 1.5 3.4 3 0 0 3 3 3 2 PHD-finger eIF-1a PF01176.14 EFX02516.1 - 0.082 12.3 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 C1_1 PF00130.17 EFX02516.1 - 3.4 7.4 11.0 0.61 9.8 0.7 3.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GalP_UDP_tr_C PF02744.12 EFX02517.1 - 1.5e-55 187.3 0.0 2.7e-55 186.4 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.17 EFX02517.1 - 3.1e-52 177.2 1.0 2.7e-32 112.2 0.3 3.1 2 1 1 3 3 3 2 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.18 EFX02517.1 - 0.036 14.6 0.0 0.088 13.3 0.0 1.7 1 0 0 1 1 1 0 HIT domain HEAT_EZ PF13513.1 EFX02518.1 - 3.5e-22 78.2 10.0 2e-06 28.0 0.0 12.6 12 2 2 14 14 13 3 HEAT-like repeat HEAT PF02985.17 EFX02518.1 - 4e-22 76.2 2.3 0.0017 18.2 0.0 10.7 12 0 0 12 12 12 4 HEAT repeat HEAT_2 PF13646.1 EFX02518.1 - 3.8e-21 75.1 20.4 0.00035 20.7 0.1 9.8 3 2 5 8 8 8 6 HEAT repeats Vac14_Fab1_bd PF12755.2 EFX02518.1 - 4.4e-11 43.0 0.0 0.023 15.0 0.0 5.2 3 1 2 5 5 4 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 EFX02518.1 - 1e-09 37.2 0.0 0.0058 15.0 0.0 5.1 3 2 2 5 5 5 3 Adaptin N terminal region IBN_N PF03810.14 EFX02518.1 - 1.8e-08 34.1 1.9 1.3e-05 25.0 0.0 4.2 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cnd1 PF12717.2 EFX02518.1 - 1.6e-05 24.8 0.0 0.041 13.7 0.0 4.3 2 2 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EFX02518.1 - 4.2e-05 23.2 1.1 15 5.5 0.0 6.9 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat RIX1 PF08167.7 EFX02518.1 - 9.6e-05 22.1 0.0 0.038 13.6 0.0 3.7 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis CLASP_N PF12348.3 EFX02518.1 - 0.00022 20.6 0.0 0.29 10.4 0.0 3.8 3 1 1 4 4 4 1 CLASP N terminal ParcG PF10274.4 EFX02518.1 - 0.0028 17.6 0.2 0.44 10.4 0.0 3.6 4 0 0 4 4 4 1 Parkin co-regulated protein MMS19_C PF12460.3 EFX02518.1 - 0.017 13.8 8.9 0.42 9.2 0.0 5.0 4 1 0 5 5 5 0 RNAPII transcription regulator C-terminal UME PF08064.8 EFX02518.1 - 0.082 12.8 0.0 57 3.7 0.0 4.4 5 0 0 5 5 5 0 UME (NUC010) domain SPDY PF03771.11 EFX02518.1 - 1.3 8.6 4.6 0.81 9.2 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF317) WD40 PF00400.27 EFX02519.1 - 2.2e-56 185.8 18.9 2e-09 36.9 0.0 8.6 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.3 EFX02519.1 - 0.0012 17.0 4.6 1.5 6.8 0.2 5.2 3 1 2 5 5 5 2 Nucleoporin Nup120/160 PQQ_2 PF13360.1 EFX02519.1 - 0.0056 16.1 0.4 5.7 6.3 0.0 3.2 3 0 0 3 3 3 2 PQQ-like domain 3Beta_HSD PF01073.14 EFX02520.1 - 6.1e-63 212.1 0.0 7.9e-63 211.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EFX02520.1 - 2e-32 112.5 0.3 2.9e-32 112.0 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFX02520.1 - 2e-14 53.1 0.1 1.9e-12 46.6 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.12 EFX02520.1 - 3.5e-13 49.0 0.3 4.8e-13 48.6 0.2 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 EFX02520.1 - 9.6e-13 48.5 0.1 5.8e-12 46.0 0.0 1.8 1 1 1 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFX02520.1 - 3.1e-09 36.1 0.0 3e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.8 EFX02520.1 - 1e-05 24.9 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 EFX02520.1 - 1.3e-05 25.2 0.0 3.3e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX02520.1 - 0.00071 19.2 0.1 0.0021 17.7 0.1 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_3 PF03447.11 EFX02520.1 - 0.005 17.2 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain TrkA_N PF02254.13 EFX02520.1 - 0.019 14.9 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain DapB_N PF01113.15 EFX02520.1 - 0.091 12.6 0.1 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Proteasome PF00227.21 EFX02521.1 - 2e-60 203.3 0.1 2.4e-60 203.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFX02521.1 - 2.8e-14 52.1 0.2 6.9e-14 50.8 0.1 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.9 EFX02521.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Ribosomal_L29 PF00831.18 EFX02522.1 - 2.1e-18 65.7 1.1 2.1e-18 65.7 0.7 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein Ribosomal_S9 PF00380.14 EFX02522.1 - 0.01 16.0 2.7 0.013 15.7 1.9 1.1 1 0 0 1 1 1 0 Ribosomal protein S9/S16 DUF2450 PF10475.4 EFX02522.1 - 0.11 11.3 3.0 0.13 11.1 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Exonuc_VII_L PF02601.10 EFX02522.1 - 0.55 9.3 5.0 0.65 9.1 3.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit RGS PF00615.14 EFX02523.1 - 4.7e-05 23.4 0.0 0.00022 21.3 0.0 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Sugar_tr PF00083.19 EFX02524.1 - 8.3e-74 248.7 23.6 9.7e-74 248.5 16.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX02524.1 - 4.5e-13 48.6 43.1 2.1e-11 43.1 18.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX02524.1 - 0.15 10.3 29.3 0.08 11.3 1.5 3.7 2 2 2 4 4 4 0 MFS/sugar transport protein Sugar_tr PF00083.19 EFX02525.1 - 4.5e-48 163.9 1.6 4.5e-48 163.9 1.1 1.8 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX02525.1 - 1.6e-16 60.0 13.7 2.7e-13 49.3 4.9 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX02525.1 - 0.00023 19.7 4.8 0.00023 19.7 3.3 2.3 3 1 0 3 3 3 1 MFS/sugar transport protein LUC7 PF03194.10 EFX02526.1 - 2.4e-69 233.7 0.4 2.9e-69 233.4 0.3 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Peptidase_M17 PF00883.16 EFX02526.1 - 0.0067 15.3 0.0 0.0092 14.8 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DUF1241 PF06840.6 EFX02526.1 - 0.018 14.3 0.2 0.15 11.3 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1241) MCPsignal PF00015.16 EFX02526.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DASH_Duo1 PF08651.5 EFX02526.1 - 0.091 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Duo1 Spc7 PF08317.6 EFX02526.1 - 0.092 11.3 0.2 0.15 10.6 0.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4200 PF13863.1 EFX02526.1 - 0.22 11.4 3.0 1.5 8.7 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) 2-oxoacid_dh PF00198.18 EFX02527.1 - 2.1e-69 233.3 0.0 3.1e-69 232.7 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EFX02527.1 - 3e-18 65.2 0.1 6.3e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 EFX02527.1 - 2.4e-11 43.0 0.0 1e-10 41.0 0.0 2.1 1 0 0 1 1 1 1 e3 binding domain NTP_transferase PF00483.18 EFX02528.1 - 1.2e-28 100.0 0.0 1.7e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EFX02528.1 - 6.5e-10 38.0 6.9 6.8e-06 25.3 0.1 3.8 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EFX02528.1 - 8.8e-06 25.8 0.0 1.4e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 EFX02528.1 - 0.051 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CRCB PF02537.10 EFX02529.1 - 1.6e-30 105.3 16.9 4.7e-17 61.9 6.6 3.7 3 0 0 3 3 3 3 CrcB-like protein Arrestin_N PF00339.24 EFX02529.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.7 EFX02529.1 - 0.54 9.3 0.0 0.86 8.7 0.0 1.2 1 0 0 1 1 1 0 Bul1 C terminus NYN PF01936.13 EFX02531.1 - 2.2e-34 118.8 0.0 3.5e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 NYN domain OST-HTH PF12872.2 EFX02531.1 - 1.4e-12 47.2 0.0 2.7e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Agro_virD5 PF04730.7 EFX02531.1 - 0.13 10.2 0.0 0.17 9.8 0.0 1.1 1 0 0 1 1 1 0 Agrobacterium VirD5 protein DUF3405 PF11885.3 EFX02532.1 - 4.4e-212 704.7 0.0 5.9e-212 704.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) TFIIF_alpha PF05793.7 EFX02532.1 - 0.14 10.5 6.0 0.21 9.9 4.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sigma70_ner PF04546.8 EFX02532.1 - 0.67 9.5 2.0 1.2 8.7 1.4 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EFX02532.1 - 0.86 9.9 4.6 2.2 8.6 3.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M41 PF01434.13 EFX02533.1 - 3e-74 249.0 0.0 4.5e-74 248.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EFX02533.1 - 1.9e-42 144.5 0.0 3.4e-42 143.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 EFX02533.1 - 2.9e-11 43.5 0.0 7e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.9 EFX02533.1 - 0.0024 17.5 0.0 0.0096 15.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EFX02533.1 - 0.0038 16.0 0.1 0.0068 15.1 0.1 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 EFX02533.1 - 0.0065 15.8 0.7 0.023 14.1 0.2 2.1 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 EFX02533.1 - 0.0066 16.1 0.7 0.04 13.6 0.5 2.4 1 0 0 1 1 1 1 Part of AAA domain AAA_2 PF07724.9 EFX02533.1 - 0.018 14.9 0.0 0.055 13.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 EFX02533.1 - 0.018 15.8 0.1 0.069 13.9 0.0 2.1 2 0 0 2 2 1 0 AAA domain RuvB_N PF05496.7 EFX02533.1 - 0.021 13.9 0.0 0.041 12.9 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFX02533.1 - 0.024 14.7 0.7 0.73 9.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.12 EFX02533.1 - 0.025 13.9 0.0 0.066 12.6 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.7 EFX02533.1 - 0.03 13.4 0.0 0.06 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 EFX02533.1 - 0.05 13.5 1.0 0.41 10.6 0.1 2.8 2 1 1 3 3 3 0 AAA ATPase domain AAA_14 PF13173.1 EFX02533.1 - 0.084 12.7 0.0 0.31 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Nucleoporin_C PF03177.9 EFX02534.1 - 1.3e-128 430.1 2.8 1.8e-128 429.6 1.9 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EFX02534.1 - 1.5e-85 287.4 0.0 2.3e-85 286.8 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like DUF1073 PF06381.6 EFX02534.1 - 0.0064 14.9 0.1 0.012 14.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1073) TLP-20 PF06088.6 EFX02535.1 - 0.55 9.8 4.4 0.24 11.0 0.2 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) BTV_NS2 PF04514.7 EFX02535.1 - 0.71 8.6 4.4 1.3 7.8 3.0 1.4 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 p450 PF00067.17 EFX02538.1 - 7.6e-15 54.3 0.0 2.4e-14 52.7 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF3818 PF12825.2 EFX02539.1 - 1.3e-130 435.1 2.8 1.9e-130 434.4 1.9 1.3 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) FAD_binding_2 PF00890.19 EFX02539.1 - 3.1e-124 415.0 2.2 4.2e-124 414.5 1.6 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 EFX02539.1 - 7.5e-46 155.1 0.1 1.5e-45 154.2 0.1 1.5 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term PXB PF12828.2 EFX02539.1 - 1.7e-41 141.0 1.2 1.1e-40 138.4 0.5 2.2 2 0 0 2 2 2 1 PX-associated PX PF00787.19 EFX02539.1 - 7.7e-10 38.5 0.1 7.8e-09 35.3 0.0 2.7 2 1 0 2 2 2 1 PX domain Pyr_redox_2 PF07992.9 EFX02539.1 - 0.00032 20.6 0.0 0.22 11.3 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX02539.1 - 0.0014 17.5 0.4 0.31 9.8 0.7 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.12 EFX02539.1 - 0.0042 16.2 0.1 0.042 12.9 0.0 2.2 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 EFX02539.1 - 0.0059 15.5 0.1 0.018 13.9 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFX02539.1 - 0.019 14.0 0.1 0.031 13.3 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Cu_amine_oxid PF01179.15 EFX02540.1 - 3.8e-167 556.1 0.0 4.6e-167 555.9 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 EFX02540.1 - 1.2e-22 79.8 0.3 5.3e-22 77.7 0.1 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 EFX02540.1 - 4.8e-15 55.4 0.0 7.7e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain DUF1680 PF07944.7 EFX02541.1 - 3.2e-92 309.4 0.1 4.5e-92 308.9 0.1 1.1 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) zf-C2H2_4 PF13894.1 EFX02541.1 - 0.00027 21.0 6.3 0.095 13.0 1.7 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX02541.1 - 0.015 15.5 0.7 0.039 14.2 0.5 1.8 1 0 0 1 1 1 0 Zinc-finger double domain zf-Di19 PF05605.7 EFX02541.1 - 0.043 13.9 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EFX02541.1 - 3.1 8.3 15.9 0.57 10.6 0.9 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type AICARFT_IMPCHas PF01808.13 EFX02542.1 - 4.1e-110 367.7 0.0 5.2e-110 367.4 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 EFX02542.1 - 6e-23 80.5 0.0 1.1e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain DnaB_bind PF10410.4 EFX02544.1 - 0.019 14.9 0.0 0.048 13.6 0.0 1.6 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase Abhydrolase_6 PF12697.2 EFX02544.1 - 0.034 14.0 0.2 0.039 13.8 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Anp1 PF03452.9 EFX02545.1 - 5.2e-104 347.1 0.0 6.3e-104 346.8 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 EFX02545.1 - 0.0012 18.5 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Peptidase_M49 PF03571.10 EFX02546.1 - 1.1e-189 631.1 0.0 1.5e-165 551.4 0.0 2.0 1 1 1 2 2 2 2 Peptidase family M49 MARVEL PF01284.18 EFX02547.1 - 6.8e-08 32.4 8.3 6.8e-08 32.4 5.8 1.5 1 1 0 1 1 1 1 Membrane-associating domain DUF4281 PF14108.1 EFX02547.1 - 0.011 15.7 0.9 0.019 15.0 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4281) Fungal_trans PF04082.13 EFX02549.1 - 6.5e-09 35.0 0.0 1.3e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02549.1 - 0.0067 16.3 9.1 0.0067 16.3 6.3 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rab5ip PF07019.7 EFX02551.1 - 2.4e-22 78.8 6.4 4.7e-22 77.9 4.5 1.5 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF3611 PF12263.3 EFX02551.1 - 0.0016 17.8 0.4 0.013 14.8 0.1 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3611) CorA PF01544.13 EFX02552.1 - 8.3e-05 21.7 3.9 0.00016 20.8 2.7 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SPOC PF07744.8 EFX02553.1 - 7.6e-18 65.1 0.0 1.4e-17 64.2 0.0 1.5 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.9 EFX02553.1 - 2.3e-17 63.0 0.0 5.1e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.24 EFX02553.1 - 1.8e-09 37.1 7.1 3.7e-09 36.1 4.9 1.5 1 0 0 1 1 1 1 PHD-finger Stk19 PF10494.4 EFX02554.1 - 1.2e-43 149.2 0.0 1.8e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Proteasome PF00227.21 EFX02555.1 - 8.8e-47 158.8 0.1 1e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF554 PF04474.7 EFX02555.1 - 0.0092 15.1 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF554) DEAD PF00270.24 EFX02556.1 - 7.3e-43 145.9 0.0 1.3e-41 141.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX02556.1 - 2.3e-24 85.0 0.0 5.6e-24 83.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFX02556.1 - 0.009 14.8 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFX02556.1 - 0.024 14.4 0.0 0.099 12.4 0.0 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Peptidase_M22 PF00814.20 EFX02557.1 - 2.3e-47 161.7 0.0 4.6e-45 154.2 0.0 2.8 1 1 0 1 1 1 1 Glycoprotease family Transp_cyt_pur PF02133.10 EFX02558.1 - 9.3e-25 87.0 40.9 1.5e-24 86.3 28.3 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin GMC_oxred_N PF00732.14 EFX02560.1 - 4.3e-14 52.3 0.0 8.8e-14 51.3 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EFX02560.1 - 7.7e-09 34.9 0.8 0.0002 20.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GMC_oxred_C PF05199.8 EFX02560.1 - 1.6e-07 31.7 0.0 3.4e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EFX02560.1 - 2.2e-06 26.8 0.0 7.6e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 EFX02560.1 - 2.3e-06 27.8 0.1 0.016 15.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFX02560.1 - 3.7e-05 22.9 0.2 0.00015 20.9 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX02560.1 - 4.1e-05 22.2 0.2 0.0011 17.5 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.9 EFX02560.1 - 6.6e-05 22.8 0.0 0.0049 16.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX02560.1 - 7.1e-05 21.8 0.3 0.0017 17.3 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.12 EFX02560.1 - 0.0022 17.1 0.3 0.01 14.9 0.0 1.9 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.22 EFX02560.1 - 0.017 15.5 0.0 0.036 14.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EFX02560.1 - 0.028 13.3 0.0 0.089 11.6 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.14 EFX02560.1 - 0.053 12.5 0.3 0.076 12.0 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.1 EFX02560.1 - 0.067 13.2 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_hydro_76 PF03663.9 EFX02561.1 - 3.1e-153 510.5 28.0 3.9e-153 510.2 19.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 UQ_con PF00179.21 EFX02562.1 - 1.1e-27 96.1 0.0 1.2e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX02562.1 - 0.025 14.3 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B ATP-synt_10 PF05176.9 EFX02563.1 - 5.2e-41 140.5 0.0 7.8e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 ATP10 protein HEV_ORF1 PF02444.11 EFX02563.1 - 0.56 10.4 4.2 4.6 7.4 2.9 2.3 1 1 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) Mito_carr PF00153.22 EFX02565.1 - 6.1e-40 134.8 6.2 4e-16 58.5 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_A4 PF01828.12 EFX02566.1 - 3.1e-80 268.1 7.7 3.7e-80 267.8 5.3 1.1 1 0 0 1 1 1 1 Peptidase A4 family Fungal_trans PF04082.13 EFX02567.1 - 3.8e-10 39.0 0.1 5.1e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3249 PF11615.3 EFX02567.1 - 0.18 11.5 0.1 0.41 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3249) UPF0113 PF03657.8 EFX02568.1 - 6.9e-07 29.0 0.0 1.5e-06 27.9 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0113) Nol1_Nop2_Fmu_2 PF13636.1 EFX02568.1 - 0.0043 17.0 0.0 0.0093 16.0 0.0 1.5 1 0 0 1 1 1 1 pre-rRNA processing and ribosome biogenesis PUA PF01472.15 EFX02568.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 PUA domain Glyco_transf_34 PF05637.7 EFX02569.1 - 6.6e-67 225.4 1.1 8.8e-67 225.0 0.8 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Gly_transf_sug PF04488.10 EFX02570.1 - 5.9e-11 42.6 0.2 2.8e-10 40.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Acyl_transf_3 PF01757.17 EFX02571.1 - 3e-17 62.4 22.8 3e-17 62.4 15.8 1.5 1 1 1 2 2 2 1 Acyltransferase family Colicin_im PF03857.8 EFX02571.1 - 0.36 10.5 2.7 0.24 11.1 0.2 1.9 2 0 0 2 2 2 0 Colicin immunity protein PI3_PI4_kinase PF00454.22 EFX02572.1 - 2.1e-30 105.9 0.0 3.8e-30 105.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 EFX02572.1 - 1.1e-17 63.5 0.0 2.6e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PLA2_B PF01735.13 EFX02573.1 - 1e-22 79.9 0.0 2.3e-22 78.8 0.0 1.5 1 1 0 1 1 1 1 Lysophospholipase catalytic domain PgaD PF13994.1 EFX02573.1 - 0.012 15.0 0.0 0.032 13.6 0.0 1.7 1 0 0 1 1 1 0 PgaD-like protein Afaf PF15339.1 EFX02573.1 - 0.017 14.7 0.9 0.044 13.3 0.6 1.6 1 0 0 1 1 1 0 Acrosome formation-associated factor DUF1990 PF09348.5 EFX02573.1 - 0.019 14.6 0.4 0.073 12.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1990) PRP1_N PF06424.7 EFX02573.1 - 1.3 9.3 8.5 0.15 12.3 0.2 2.9 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal DEAD PF00270.24 EFX02574.1 - 2e-45 154.3 0.0 4.3e-44 149.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX02574.1 - 3.8e-28 97.1 0.1 7.5e-28 96.2 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX02574.1 - 0.055 13.2 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DEC-1_N PF04625.8 EFX02574.1 - 0.06 12.0 13.5 0.086 11.5 9.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF1253 PF06862.7 EFX02574.1 - 0.13 10.6 0.0 0.24 9.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) CMS1 PF14617.1 EFX02574.1 - 0.19 10.8 0.0 0.34 9.9 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit HORMA PF02301.13 EFX02575.1 - 1.4e-44 152.1 0.0 1.6e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 HORMA domain DEAD PF00270.24 EFX02577.1 - 5.8e-22 77.9 0.0 3.5e-20 72.1 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX02577.1 - 2.8e-21 75.1 0.0 6.9e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX02577.1 - 5.3e-20 72.0 0.1 2.8e-19 69.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFX02577.1 - 0.004 17.2 0.0 0.015 15.4 0.0 2.0 1 1 1 2 2 2 1 AAA domain SAGA-Tad1 PF12767.2 EFX02578.1 - 1.9e-51 175.1 0.0 3.8e-51 174.1 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit C2 PF00168.25 EFX02579.1 - 1e-69 230.3 0.4 2.1e-19 69.1 0.0 5.6 5 0 0 5 5 5 5 C2 domain Corona_nucleoca PF00937.13 EFX02580.1 - 0.0075 15.2 14.3 0.0075 15.2 9.9 2.5 3 0 0 3 3 3 1 Coronavirus nucleocapsid protein EthD PF07110.6 EFX02581.1 - 4.6e-21 75.5 0.1 5.2e-21 75.3 0.1 1.0 1 0 0 1 1 1 1 EthD domain WD40 PF00400.27 EFX02582.1 - 5.1e-40 133.9 8.6 1.3e-09 37.5 0.3 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 EFX02582.1 - 1.6e-06 26.5 9.9 0.041 12.0 0.1 4.7 2 2 3 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFX02582.1 - 0.22 10.2 0.0 33 3.0 0.0 3.1 3 1 1 4 4 4 0 Nup133 N terminal like Methyltransf_23 PF13489.1 EFX02584.1 - 8.3e-20 71.1 0.0 1.2e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02584.1 - 6.1e-17 61.9 0.0 2e-15 57.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02584.1 - 8.3e-15 55.3 0.0 1.3e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02584.1 - 3.1e-14 53.2 0.0 5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX02584.1 - 2.3e-11 43.9 0.0 5.9e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02584.1 - 2.7e-11 43.2 0.0 3.3e-10 39.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX02584.1 - 1.6e-09 37.7 0.4 4.5e-09 36.3 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX02584.1 - 2.5e-06 26.9 0.0 5.6e-06 25.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.8 EFX02584.1 - 0.0031 16.6 0.0 0.0052 15.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 EFX02584.1 - 0.0032 16.6 0.0 0.42 9.6 0.0 2.1 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 EFX02584.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FmrO PF07091.6 EFX02584.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) PCMT PF01135.14 EFX02584.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PI-PLC-X PF00388.14 EFX02585.1 - 5.5e-07 29.0 0.0 8.7e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain adh_short PF00106.20 EFX02586.1 - 2.4e-15 56.8 1.4 4.3e-15 56.0 1.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX02586.1 - 0.00013 21.8 0.6 0.00045 20.0 0.4 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX02586.1 - 0.00016 21.4 1.2 0.00032 20.4 0.7 1.8 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 EFX02586.1 - 0.00076 18.8 0.4 0.00076 18.8 0.3 2.0 3 0 0 3 3 3 1 NmrA-like family Epimerase PF01370.16 EFX02586.1 - 0.0031 16.9 0.5 0.0093 15.4 0.4 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFX02586.1 - 0.051 12.4 0.5 0.3 9.9 0.1 2.3 2 1 0 2 2 2 0 Male sterility protein NAD_binding_10 PF13460.1 EFX02586.1 - 0.075 13.0 1.2 0.2 11.6 0.8 1.9 1 1 0 1 1 1 0 NADH(P)-binding Glyco_transf_22 PF03901.12 EFX02587.1 - 2e-68 231.3 18.2 2.5e-68 231.0 12.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family LigD_N PF13298.1 EFX02587.1 - 0.044 13.8 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase Ligase (LigD) NPDC1 PF06809.6 EFX02587.1 - 0.048 12.4 1.0 1.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Neural proliferation differentiation control-1 protein (NPDC1) DUF500 PF04366.7 EFX02589.1 - 2.8e-27 94.6 0.0 5e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF500) NOG1 PF06858.9 EFX02591.1 - 4.6e-22 77.6 0.0 1e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.6 EFX02591.1 - 4.3e-20 71.1 0.5 1.1e-19 69.8 0.4 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.18 EFX02591.1 - 1.5e-11 44.3 0.0 4e-11 42.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX02591.1 - 0.00036 19.8 0.0 0.00071 18.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EFX02591.1 - 0.012 15.4 0.3 3.4 7.4 0.1 2.7 1 1 1 2 2 2 0 Dynamin family DNA_pol_phi PF04931.8 EFX02591.1 - 0.83 7.3 10.8 1.2 6.8 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi adh_short PF00106.20 EFX02592.1 - 6.1e-20 71.8 0.0 7.9e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX02592.1 - 5.9e-06 26.0 0.1 1e-05 25.2 0.1 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX02592.1 - 2.4e-05 23.9 0.0 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 EFX02592.1 - 0.00012 21.9 0.0 0.00016 21.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 2-Hacid_dh_C PF02826.14 EFX02592.1 - 0.00083 18.5 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFX02592.1 - 0.0011 19.1 0.2 0.0026 17.8 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 EFX02592.1 - 0.0011 19.3 1.0 0.002 18.5 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.1 EFX02592.1 - 0.0011 18.9 0.1 0.0018 18.3 0.1 1.4 1 1 0 1 1 1 1 NADH(P)-binding DUF1776 PF08643.5 EFX02592.1 - 0.004 16.3 0.0 0.0062 15.7 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.8 EFX02592.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family RmlD_sub_bind PF04321.12 EFX02592.1 - 0.042 12.7 0.0 0.068 12.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Inhibitor_G39P PF11417.3 EFX02592.1 - 0.048 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Loader and inhibitor of phage G40P Voltage_CLC PF00654.15 EFX02593.1 - 1.2e-89 300.7 27.9 1.9e-89 300.1 19.3 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.23 EFX02593.1 - 0.0037 17.0 0.0 1.7 8.4 0.0 2.6 2 0 0 2 2 2 2 CBS domain zf-GRF PF06839.7 EFX02594.1 - 1.2e-09 37.9 2.6 2.1e-09 37.1 1.8 1.4 1 0 0 1 1 1 1 GRF zinc finger Use1 PF09753.4 EFX02595.1 - 1.6e-08 34.3 0.4 4.8e-08 32.7 0.3 2.0 1 1 0 1 1 1 1 Membrane fusion protein Use1 Med17 PF10156.4 EFX02596.1 - 5.2e-68 229.4 0.0 2.6e-67 227.1 0.0 1.8 1 1 0 1 1 1 1 Subunit 17 of Mediator complex Mto2_bdg PF12808.2 EFX02596.1 - 2.1 8.4 8.0 0.54 10.4 0.7 3.0 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Fungal_trans PF04082.13 EFX02598.1 - 1.1e-14 54.0 0.0 8.3e-14 51.0 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02598.1 - 2.7e-07 30.3 7.2 2.7e-07 30.3 5.0 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UCH PF00443.24 EFX02601.1 - 7.9e-46 156.3 0.0 4.9e-35 120.9 0.0 2.8 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX02601.1 - 9.5e-20 71.2 0.0 1.7e-14 53.9 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PDT PF00800.13 EFX02602.1 - 3.2e-58 196.2 0.0 5.2e-58 195.5 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 EFX02602.1 - 0.0026 17.2 0.1 0.012 15.0 0.0 2.2 2 1 0 2 2 2 1 ACT domain Phytase-like PF13449.1 EFX02602.1 - 0.078 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Esterase-like activity of phytase Epimerase PF01370.16 EFX02603.1 - 2e-56 191.1 0.0 2.5e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFX02603.1 - 8.1e-23 80.7 0.0 7.8e-22 77.5 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EFX02603.1 - 1.5e-21 76.5 0.0 7.8e-21 74.1 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 EFX02603.1 - 1.2e-20 73.4 0.0 1.6e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EFX02603.1 - 5e-20 71.5 0.0 6.6e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 EFX02603.1 - 2.8e-09 37.2 0.0 5e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EFX02603.1 - 0.00029 20.7 0.0 0.039 13.8 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase Lipase3_N PF03893.11 EFX02603.1 - 0.1 12.4 0.0 8.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Lipase 3 N-terminal region NmrA PF05368.8 EFX02603.1 - 0.12 11.5 0.0 0.28 10.4 0.0 1.7 2 1 0 2 2 2 0 NmrA-like family Methyltransf_18 PF12847.2 EFX02603.1 - 0.14 12.7 0.0 0.85 10.2 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Fungal_trans PF04082.13 EFX02604.1 - 1.7e-20 72.9 2.2 6.5e-19 67.8 1.5 2.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF2088 PF09861.4 EFX02604.1 - 0.00014 20.9 0.0 0.00035 19.6 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2088) Nop14 PF04147.7 EFX02604.1 - 0.018 12.9 8.8 0.028 12.3 6.1 1.2 1 0 0 1 1 1 0 Nop14-like family Zn_clus PF00172.13 EFX02604.1 - 0.31 11.0 16.6 0.61 10.0 11.5 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Trypan_PARP PF05887.6 EFX02604.1 - 0.4 10.4 3.9 0.89 9.3 2.7 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GCIP PF13324.1 EFX02604.1 - 1.2 8.3 5.6 2.2 7.4 3.8 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting SDA1 PF05285.7 EFX02604.1 - 2.6 7.2 12.3 4.6 6.4 8.5 1.3 1 0 0 1 1 1 0 SDA1 Vps54 PF07928.7 EFX02605.1 - 5.1e-35 120.5 0.0 1.7e-34 118.8 0.0 1.9 2 0 0 2 2 2 1 Vps54-like protein DUF2450 PF10475.4 EFX02605.1 - 9.2e-06 24.7 0.2 3e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 EFX02605.1 - 0.00014 21.7 0.0 0.00079 19.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Glyco_hydro_17 PF00332.13 EFX02606.1 - 5.7e-05 22.3 1.1 0.00014 21.0 0.8 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 Glyco_hydro_53 PF07745.8 EFX02606.1 - 0.038 12.7 0.0 0.058 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 NAD_kinase PF01513.16 EFX02607.1 - 1.9e-70 236.8 0.0 3.2e-70 236.1 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DUF2034 PF10356.4 EFX02608.1 - 1.5e-27 95.9 0.0 5.9e-13 48.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 EFX02608.1 - 1.8e-06 27.7 0.0 3e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Restriction endonuclease Y_phosphatase3 PF13350.1 EFX02609.1 - 6.1e-37 127.3 0.0 8.5e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 EFX02609.1 - 2.4e-05 24.3 0.0 7.4e-05 22.7 0.0 1.9 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region PTPlike_phytase PF14566.1 EFX02609.1 - 0.063 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate ACT_6 PF13740.1 EFX02609.1 - 0.11 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 ACT domain Y_phosphatase PF00102.22 EFX02609.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ArfGap PF01412.13 EFX02610.1 - 5.4e-39 132.6 0.2 1.2e-38 131.4 0.2 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf UBA PF00627.26 EFX02610.1 - 0.023 14.5 0.1 0.066 13.0 0.1 1.8 1 0 0 1 1 1 0 UBA/TS-N domain PIG-X PF08320.7 EFX02612.1 - 3.3e-67 225.7 0.0 5.8e-67 224.9 0.0 1.4 1 0 0 1 1 1 1 PIG-X / PBN1 YadA_anchor PF03895.10 EFX02613.1 - 0.25 11.4 3.0 0.16 11.9 0.6 1.8 2 0 0 2 2 2 0 YadA-like C-terminal region Sec1 PF00995.18 EFX02614.1 - 7.9e-131 437.4 0.0 9e-131 437.2 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sybindin PF04099.7 EFX02615.1 - 7.6e-27 93.7 0.0 9.2e-27 93.5 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 EFX02615.1 - 0.0092 15.8 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region G10 PF01125.12 EFX02616.1 - 6.3e-62 207.4 4.0 7.1e-62 207.2 2.7 1.0 1 0 0 1 1 1 1 G10 protein ketoacyl-synt PF00109.21 EFX02617.1 - 3.2e-73 246.3 0.1 1.1e-72 244.6 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX02617.1 - 2e-52 178.4 0.2 1.2e-51 175.9 0.1 2.2 2 0 0 2 2 2 1 Acyl transferase domain Thioesterase PF00975.15 EFX02617.1 - 2.7e-36 125.9 0.0 1e-35 124.0 0.0 2.0 2 0 0 2 2 2 1 Thioesterase domain Ketoacyl-synt_C PF02801.17 EFX02617.1 - 7.3e-35 119.3 0.6 2e-34 117.9 0.4 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFX02617.1 - 8.2e-25 86.8 4.5 1.1e-11 44.8 0.2 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.1 EFX02617.1 - 2.5e-16 59.6 0.0 6.4e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Abhydrolase_5 PF12695.2 EFX02617.1 - 1.9e-06 27.7 0.8 0.14 11.9 0.0 3.7 3 0 0 3 3 3 2 Alpha/beta hydrolase family Thiolase_N PF00108.18 EFX02617.1 - 0.00044 19.3 0.2 0.0012 17.9 0.1 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain DUF3701 PF12482.3 EFX02617.1 - 0.063 13.0 0.1 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 Phage integrase protein Methyltransf_23 PF13489.1 EFX02618.1 - 1.2e-22 80.3 0.0 1.7e-22 79.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02618.1 - 1.2e-09 38.7 0.1 2.4e-08 34.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02618.1 - 1.3e-09 38.4 0.0 6.9e-09 36.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02618.1 - 1.6e-08 34.2 0.0 1.7e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02618.1 - 5.1e-08 33.2 0.0 9e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFX02618.1 - 0.0014 18.0 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX02618.1 - 0.0018 18.3 0.0 0.068 13.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX02618.1 - 0.0028 17.0 0.0 0.024 13.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFX02618.1 - 0.0034 17.7 0.0 0.0094 16.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX02618.1 - 0.0063 16.5 0.0 0.035 14.0 0.0 2.2 3 0 0 3 3 3 1 FtsJ-like methyltransferase PrmA PF06325.8 EFX02618.1 - 0.008 15.3 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 EFX02618.1 - 0.087 11.8 0.0 0.18 10.8 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase CedA PF10729.4 EFX02618.1 - 0.12 11.9 0.3 0.71 9.4 0.0 2.3 3 0 0 3 3 3 0 Cell division activator CedA Aldo_ket_red PF00248.16 EFX02619.1 - 3.7e-66 222.8 0.0 4.2e-66 222.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family bZIP_1 PF00170.16 EFX02620.1 - 9.7e-07 28.6 8.9 9.7e-07 28.6 6.2 2.8 2 1 0 2 2 2 1 bZIP transcription factor PRTP PF01366.13 EFX02620.1 - 1.4 6.7 16.9 0.64 7.9 9.1 1.8 1 1 1 2 2 2 0 Herpesvirus processing and transport protein SHR3_chaperone PF08229.6 EFX02620.1 - 2.6 6.9 5.8 4 6.3 4.0 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 IncA PF04156.9 EFX02620.1 - 3.1 7.3 24.2 6.3 6.3 1.0 2.4 2 0 0 2 2 2 0 IncA protein bZIP_Maf PF03131.12 EFX02620.1 - 4 7.7 31.9 1.2 9.5 3.6 3.3 3 0 0 3 3 3 0 bZIP Maf transcription factor DUF1090 PF06476.7 EFX02620.1 - 4.8 6.8 23.5 4.6 6.9 11.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) YABBY PF04690.8 EFX02620.1 - 6.8 6.8 9.0 17 5.6 6.2 1.7 1 0 0 1 1 1 0 YABBY protein Dicty_REP PF05086.7 EFX02620.1 - 8.4 4.0 7.4 12 3.5 5.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.12 EFX02620.1 - 9 5.0 6.2 12 4.6 4.3 1.4 1 0 0 1 1 1 0 Presenilin ABC2_membrane_3 PF12698.2 EFX02620.1 - 9.6 5.1 6.8 18 4.2 4.7 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Fungal_trans PF04082.13 EFX02621.1 - 4e-20 71.7 1.3 4e-20 71.7 0.9 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02621.1 - 0.0022 17.8 11.1 0.0057 16.5 7.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clr2 PF10383.4 EFX02622.1 - 2.3e-14 53.5 0.0 3.9e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 Pkinase PF00069.20 EFX02623.1 - 4.3e-58 196.4 0.0 2.7e-57 193.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02623.1 - 3e-28 98.6 0.2 4e-20 71.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 EFX02623.1 - 2.7e-06 27.7 0.1 6.9e-06 26.4 0.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFX02623.1 - 0.00044 19.3 0.1 0.0024 16.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFX02623.1 - 0.0083 15.8 4.4 0.092 12.4 0.0 3.6 3 1 1 4 4 4 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFX02623.1 - 0.33 9.7 0.0 0.55 9.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 MIF4G PF02854.14 EFX02624.1 - 5.9e-51 172.8 0.0 8.4e-51 172.3 0.0 1.2 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 EFX02624.1 - 6e-21 74.1 0.1 1.7e-20 72.6 0.1 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 MMR_HSR1 PF01926.18 EFX02625.1 - 7.4e-19 67.8 0.0 2.2e-18 66.2 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.16 EFX02625.1 - 1.3e-18 66.5 0.6 2.1e-18 65.9 0.1 1.7 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.13 EFX02625.1 - 2.2e-12 46.5 0.0 3.6e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EFX02625.1 - 0.00013 21.8 0.2 0.08 12.7 0.0 2.5 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 EFX02625.1 - 0.0064 16.9 0.0 0.019 15.4 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein ArgK PF03308.11 EFX02625.1 - 0.044 12.5 0.1 0.11 11.2 0.1 1.7 1 0 0 1 1 1 0 ArgK protein AAA_28 PF13521.1 EFX02625.1 - 0.067 13.1 0.2 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain MCM PF00493.18 EFX02625.1 - 0.071 11.9 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 MCM2/3/5 family EST1_DNA_bind PF10373.4 EFX02626.1 - 5.4e-41 140.6 0.0 8.6e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.4 EFX02626.1 - 1.3e-20 73.7 6.1 2.2e-20 73.0 3.2 2.2 2 0 0 2 2 2 1 Telomerase activating protein Est1 Acyl-CoA_dh_1 PF00441.19 EFX02627.1 - 4.1e-28 98.3 1.4 7.1e-28 97.6 1.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFX02627.1 - 3e-15 55.4 0.0 1e-14 53.7 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFX02627.1 - 2.3e-13 50.5 3.9 6.5e-13 49.0 2.7 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EFX02627.1 - 2.3e-12 47.4 1.1 3.7e-12 46.8 0.2 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Arginase PF00491.16 EFX02628.1 - 4.7e-92 308.2 0.0 5.6e-92 307.9 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 EFX02628.1 - 0.026 14.7 0.1 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 UPF0489 domain ResIII PF04851.10 EFX02629.1 - 1.3e-23 83.7 0.0 2.8e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFX02629.1 - 8.6e-12 44.7 0.1 1.9e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFX02629.1 - 1.3e-11 44.2 0.0 2.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.4 EFX02629.1 - 0.0032 16.4 0.0 0.0053 15.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 EFX02629.1 - 0.037 14.1 0.0 0.19 11.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 EFX02629.1 - 0.037 12.6 0.0 0.062 11.9 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Acyl-CoA_dh_1 PF00441.19 EFX02630.1 - 4.8e-33 114.3 0.4 1e-32 113.3 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFX02630.1 - 2.1e-17 62.3 0.4 4.2e-17 61.3 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.23 EFX02630.1 - 6.8e-16 57.8 0.0 1.6e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.11 EFX02630.1 - 8.3e-09 36.0 4.0 1.4e-08 35.2 0.1 3.1 3 1 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EFX02630.1 - 0.004 17.3 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HIT PF01230.18 EFX02631.1 - 1.3e-23 83.3 0.3 2e-23 82.7 0.2 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 EFX02631.1 - 0.00068 19.8 0.8 0.0019 18.3 0.6 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Mid2 PF04478.7 EFX02633.1 - 4.2e-08 32.7 0.3 4.2e-08 32.7 0.2 2.3 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor Phage_attach PF05354.6 EFX02633.1 - 0.063 12.8 0.7 0.2 11.2 0.5 1.8 1 0 0 1 1 1 0 Phage Head-Tail Attachment MFS_1 PF07690.11 EFX02634.1 - 1.7e-35 122.4 26.9 3.8e-35 121.2 18.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX02634.1 - 0.0014 16.8 5.0 0.0014 16.8 3.5 2.2 1 1 2 3 3 3 1 Fungal trichothecene efflux pump (TRI12) TPT PF03151.11 EFX02634.1 - 0.004 16.8 1.2 0.22 11.1 0.0 2.9 2 1 0 2 2 2 1 Triose-phosphate Transporter family ESSS PF10183.4 EFX02634.1 - 2.2 8.7 6.4 0.55 10.6 0.2 3.0 3 1 1 4 4 4 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF4064 PF13273.1 EFX02634.1 - 10 6.3 10.5 2 8.5 1.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) ADH_N PF08240.7 EFX02635.1 - 4.5e-28 97.1 3.3 7.7e-28 96.4 2.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX02635.1 - 2.8e-11 43.0 0.0 6.8e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX02635.1 - 3.4e-06 27.9 0.1 1.2e-05 26.1 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 EFX02635.1 - 0.0091 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.14 EFX02635.1 - 0.058 12.5 0.0 0.14 11.3 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_18 PF12847.2 EFX02635.1 - 0.067 13.7 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.11 EFX02636.1 - 1.9e-13 49.8 39.5 2.8e-13 49.3 27.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFX02636.1 - 1.6e-07 30.9 6.4 1.6e-07 30.9 4.5 2.8 3 1 1 4 4 4 1 Ion channel regulatory protein UNC-93 DUF4149 PF13664.1 EFX02636.1 - 3.1 7.8 13.9 0.025 14.6 2.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) Zn_clus PF00172.13 EFX02637.1 - 0.038 13.8 7.4 0.091 12.6 5.2 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-BED PF02892.10 EFX02637.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.1 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.1 EFX02637.1 - 0.31 10.9 4.3 0.24 11.3 0.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger COX2_TM PF02790.10 EFX02638.1 - 0.043 13.7 0.2 0.087 12.7 0.1 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4200 PF13863.1 EFX02640.1 - 0.087 12.7 0.0 0.087 12.7 0.0 4.2 3 2 2 5 5 5 0 Domain of unknown function (DUF4200) SPX PF03105.14 EFX02640.1 - 0.68 9.6 16.8 0.26 11.0 7.5 2.4 2 0 0 2 2 2 0 SPX domain TMPIT PF07851.8 EFX02640.1 - 5.7 5.9 6.4 14 4.6 4.4 1.6 1 0 0 1 1 1 0 TMPIT-like protein PTCB-BRCT PF12738.2 EFX02641.1 - 0.018 14.8 0.0 0.072 12.9 0.0 2.1 1 1 1 2 2 2 0 twin BRCT domain BRCT PF00533.21 EFX02641.1 - 0.023 14.8 0.0 0.065 13.3 0.0 1.9 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain UreF PF01730.11 EFX02641.1 - 0.058 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 UreF ELFV_dehydrog PF00208.16 EFX02642.1 - 1.4e-56 191.8 0.0 2.4e-56 191.0 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 EFX02642.1 - 7.2e-22 76.7 0.1 9.3e-17 59.8 0.0 2.4 2 1 1 3 3 3 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 EFX02642.1 - 0.00025 20.6 0.0 0.001 18.6 0.0 2.0 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF556 PF04476.8 EFX02642.1 - 0.1 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF556) MFS_1 PF07690.11 EFX02643.1 - 1.6e-34 119.1 52.2 5.2e-33 114.2 19.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Transferase PF02458.10 EFX02644.1 - 5.6e-07 28.3 0.0 5.8e-06 25.0 0.0 1.9 1 1 0 1 1 1 1 Transferase family Cut12 PF11500.3 EFX02645.1 - 1.7e-37 128.4 14.5 1.7e-37 128.4 10.0 4.2 2 2 2 4 4 4 1 Spindle pole body formation-associated protein UreF PF01730.11 EFX02645.1 - 1.4e-13 51.2 0.9 1.4e-13 51.2 0.7 3.3 3 1 0 3 3 3 1 UreF Glyco_hydro_92 PF07971.7 EFX02646.1 - 8.4e-136 453.5 0.0 4.3e-71 240.0 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolase family 92 FAD_binding_3 PF01494.14 EFX02647.1 - 3.8e-14 52.5 4.3 2.4e-05 23.5 0.2 3.1 2 1 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 EFX02647.1 - 8.2e-09 35.3 0.1 5.5e-08 32.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX02647.1 - 2.5e-06 26.6 0.1 1.6e-05 23.9 0.0 2.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX02647.1 - 2.7e-05 23.1 0.2 7e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Amino_oxidase PF01593.19 EFX02647.1 - 7.2e-05 22.0 0.0 0.12 11.4 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 EFX02647.1 - 0.0022 18.3 0.0 0.045 14.1 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX02647.1 - 0.0037 17.1 0.0 0.0062 16.4 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX02647.1 - 0.0043 15.5 0.1 0.012 14.1 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.7 EFX02647.1 - 0.0051 15.7 0.3 0.23 10.3 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.12 EFX02647.1 - 0.0096 15.0 0.1 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 EFX02647.1 - 0.01 15.8 0.0 0.014 15.5 0.0 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX02647.1 - 0.012 15.4 0.1 0.17 11.6 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding XdhC_C PF13478.1 EFX02647.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain GIDA PF01134.17 EFX02647.1 - 0.14 11.0 0.1 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Mito_carr PF00153.22 EFX02648.1 - 4.6e-60 199.3 0.1 3e-21 74.9 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Aminotran_1_2 PF00155.16 EFX02649.1 - 5e-14 52.0 0.0 7e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 EFX02649.1 - 0.00054 18.6 0.0 0.022 13.3 0.0 2.1 2 0 0 2 2 2 2 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.12 EFX02649.1 - 0.022 13.8 0.0 0.11 11.5 0.0 1.9 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF4243 PF14027.1 EFX02650.1 - 2.5e-31 109.3 0.3 3.8e-31 108.7 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF4243) DUF2600 PF10776.4 EFX02650.1 - 0.016 14.0 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) Zip PF02535.17 EFX02651.1 - 5.6e-36 124.1 12.0 9.9e-35 120.0 8.3 2.4 1 1 0 1 1 1 1 ZIP Zinc transporter WD40 PF00400.27 EFX02653.1 - 1.5e-28 97.5 19.3 1.1e-08 34.5 0.3 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 EFX02653.1 - 0.17 11.6 0.0 16 5.1 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A 2-Hacid_dh_C PF02826.14 EFX02654.1 - 5e-28 97.4 0.0 4.2e-27 94.4 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX02654.1 - 0.08 12.4 0.0 0.092 12.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain FYVE PF01363.16 EFX02655.1 - 3.1e-09 36.6 1.2 3.1e-09 36.6 0.8 3.4 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 EFX02655.1 - 2.8e-08 33.4 6.3 2.8e-08 33.4 4.3 3.5 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.2 EFX02655.1 - 0.0014 18.6 12.7 0.015 15.3 3.2 3.3 3 0 0 3 3 3 2 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EFX02655.1 - 0.01 15.8 5.8 0.01 15.8 4.0 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.9 EFX02655.1 - 3 7.3 6.1 0.61 9.5 0.1 2.4 3 0 0 3 3 3 0 Rad50 zinc hook motif TPR_10 PF13374.1 EFX02656.1 - 1.6e-18 65.9 0.7 6.5e-07 29.0 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02656.1 - 8.6e-17 60.8 1.4 1.9e-12 46.9 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFX02656.1 - 9.7e-10 37.5 1.1 0.0006 19.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02656.1 - 3.3e-09 35.9 1.0 0.011 15.5 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat NB-ARC PF00931.17 EFX02656.1 - 5.1e-07 28.8 0.0 8.4e-07 28.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_1 PF00515.23 EFX02656.1 - 4.8e-06 25.9 0.1 0.046 13.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_16 PF13191.1 EFX02656.1 - 7.4e-06 26.0 0.9 9e-05 22.5 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX02656.1 - 3.4e-05 23.9 0.0 9.5e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain TPR_11 PF13414.1 EFX02656.1 - 0.00014 21.4 0.3 0.0054 16.3 0.0 2.7 2 0 0 2 2 2 1 TPR repeat PPR PF01535.15 EFX02656.1 - 0.00022 21.0 0.0 2.6 8.2 0.0 3.7 3 0 0 3 3 3 1 PPR repeat TPR_17 PF13431.1 EFX02656.1 - 0.00023 21.1 0.9 0.18 12.1 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX02656.1 - 0.0012 19.2 1.7 1 9.9 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX02656.1 - 0.0021 17.7 1.7 0.31 10.9 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX02656.1 - 0.003 17.8 0.1 0.27 11.6 0.0 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX02656.1 - 0.0036 17.9 1.1 0.73 10.5 0.2 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX02656.1 - 0.0097 16.4 0.1 15 6.5 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Pox_A32 PF04665.7 EFX02656.1 - 0.016 14.5 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein Arch_ATPase PF01637.13 EFX02656.1 - 0.027 14.1 0.0 0.05 13.2 0.0 1.6 1 1 0 1 1 1 0 Archaeal ATPase TPR_5 PF12688.2 EFX02656.1 - 0.032 14.2 0.0 3 7.9 0.0 2.8 1 1 1 2 2 2 0 Tetratrico peptide repeat ArgK PF03308.11 EFX02656.1 - 0.079 11.7 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 ArgK protein PPR_3 PF13812.1 EFX02656.1 - 0.084 13.2 0.6 18 5.9 0.0 3.3 3 0 0 3 3 2 0 Pentatricopeptide repeat domain DDE_3 PF13358.1 EFX02656.1 - 0.28 10.9 2.4 2.2 8.0 0.5 2.6 2 1 0 2 2 2 0 DDE superfamily endonuclease NPCC PF08058.6 EFX02657.1 - 3.3e-22 78.8 0.0 2.3e-20 72.9 0.0 2.2 1 1 0 1 1 1 1 Nuclear pore complex component CytochromB561_N PF09786.4 EFX02657.1 - 0.0002 19.9 0.6 0.00021 19.8 0.4 1.1 1 0 0 1 1 1 1 Cytochrome B561, N terminal CytoC_RC PF02276.13 EFX02658.1 - 0.66 9.0 3.3 0.49 9.4 1.4 1.4 1 1 1 2 2 2 0 Photosynthetic reaction centre cytochrome C subunit MFS_1 PF07690.11 EFX02659.1 - 1.4e-39 135.8 27.5 1.4e-39 135.8 19.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02659.1 - 1.8e-10 39.9 8.0 1.8e-10 39.9 5.5 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFX02659.1 - 0.00037 18.8 3.9 0.00055 18.2 2.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3099 PF11298.3 EFX02659.1 - 3.1 7.6 5.9 3.5 7.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3099) Fungal_trans PF04082.13 EFX02660.1 - 1e-15 57.3 0.3 1.7e-15 56.6 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DAO PF01266.19 EFX02661.1 - 8.8e-44 149.8 0.8 1.1e-43 149.5 0.6 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX02661.1 - 1.1e-10 41.0 8.1 4.5e-05 22.4 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.2 EFX02661.1 - 6.5e-08 32.0 2.8 6.8e-07 28.7 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX02661.1 - 1.5e-05 24.9 0.3 0.00014 21.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EFX02661.1 - 0.0019 17.2 0.5 0.023 13.6 0.2 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFX02661.1 - 0.0021 18.0 0.4 0.0059 16.6 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 EFX02661.1 - 0.0034 16.2 2.6 0.011 14.6 0.4 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.9 EFX02661.1 - 0.0041 15.6 0.8 0.0064 15.0 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EFX02661.1 - 0.0096 16.3 2.0 0.012 15.9 0.4 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EFX02661.1 - 0.01 15.4 0.2 0.01 15.4 0.2 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.12 EFX02661.1 - 0.035 13.2 1.8 0.23 10.5 0.1 2.6 2 1 0 3 3 3 0 Thi4 family Pyr_redox_3 PF13738.1 EFX02661.1 - 0.052 13.6 0.3 0.46 10.5 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Voldacs PF03517.8 EFX02664.1 - 2.5e-22 79.1 0.0 4.1e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling RNA_pol_3_Rpc31 PF11705.3 EFX02664.1 - 1.6 8.6 8.4 2.7 7.8 5.8 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 AA_permease PF00324.16 EFX02665.1 - 1.8e-131 438.7 32.4 2.2e-131 438.4 22.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX02665.1 - 1.6e-41 142.2 35.7 2.2e-41 141.8 24.7 1.1 1 0 0 1 1 1 1 Amino acid permease TPR_10 PF13374.1 EFX02665.1 - 0.001 18.9 0.0 0.001 18.9 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02665.1 - 0.0041 17.0 0.1 0.0074 16.2 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Tnp_P_element PF12017.3 EFX02665.1 - 0.18 11.0 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 Transposase protein Gemini_mov PF01708.11 EFX02666.1 - 0.82 9.2 4.1 0.41 10.2 0.5 2.2 2 0 0 2 2 2 0 Geminivirus putative movement protein TPR_10 PF13374.1 EFX02667.1 - 2.1e-66 218.1 11.6 4e-14 51.9 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 EFX02667.1 - 5.4e-63 208.8 16.6 1.2e-20 73.1 0.2 4.7 1 1 3 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 EFX02667.1 - 2.5e-21 75.0 12.3 1.3e-08 34.3 0.4 4.5 1 1 4 5 5 5 4 TPR repeat TPR_16 PF13432.1 EFX02667.1 - 2.4e-15 56.7 18.1 3e-07 30.9 0.5 4.1 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 EFX02667.1 - 1.5e-14 52.5 7.5 0.058 13.2 0.1 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.12 EFX02667.1 - 1.7e-13 49.3 13.7 0.0025 17.6 0.1 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 EFX02667.1 - 2.7e-12 45.8 0.7 0.09 13.0 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 EFX02667.1 - 2.8e-11 42.5 5.1 0.036 13.6 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.9 EFX02667.1 - 1.5e-10 40.4 11.3 0.24 11.9 0.1 6.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFX02667.1 - 6e-09 36.1 8.9 0.0023 18.2 1.5 4.3 1 1 4 5 5 5 3 Tetratricopeptide repeat NB-ARC PF00931.17 EFX02667.1 - 1.1e-06 27.6 0.0 2.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Apc3 PF12895.2 EFX02667.1 - 2.3e-06 27.6 1.1 0.14 12.2 0.1 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EFX02667.1 - 0.00012 22.3 14.5 4.4 8.2 0.1 6.0 1 1 4 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.9 EFX02667.1 - 0.00059 19.1 3.9 1.5 7.9 0.1 3.7 1 1 3 4 4 4 2 Coatomer epsilon subunit TPR_8 PF13181.1 EFX02667.1 - 0.00072 19.1 5.8 0.88 9.5 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.7 EFX02667.1 - 0.00083 19.1 1.6 0.56 10.0 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Rab5-bind PF09311.6 EFX02667.1 - 0.00085 19.2 3.6 0.18 11.7 0.2 3.3 2 1 0 3 3 3 1 Rabaptin-like protein TPR_6 PF13174.1 EFX02667.1 - 0.0063 16.8 10.5 12 6.6 0.1 5.5 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR_3 PF13812.1 EFX02667.1 - 0.014 15.6 0.9 1e+02 3.5 0.0 5.3 5 0 0 5 5 5 0 Pentatricopeptide repeat domain PPR PF01535.15 EFX02667.1 - 0.02 14.8 1.4 57 4.0 0.0 4.4 5 0 0 5 5 3 0 PPR repeat TPR_20 PF14561.1 EFX02667.1 - 0.044 13.9 6.1 32 4.7 0.1 4.8 1 1 3 4 4 4 0 Tetratricopeptide repeat Arch_ATPase PF01637.13 EFX02667.1 - 0.069 12.8 0.0 0.38 10.4 0.0 2.1 1 1 0 1 1 1 0 Archaeal ATPase Septin PF00735.13 EFX02668.1 - 5.6e-122 406.1 0.6 5.6e-122 406.1 0.4 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EFX02668.1 - 6.1e-07 29.4 0.0 1.4e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFX02668.1 - 8.6e-05 21.7 0.4 0.00047 19.3 0.3 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 EFX02668.1 - 0.00013 21.5 1.4 0.0012 18.3 0.0 2.8 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 EFX02668.1 - 0.0003 20.3 0.0 0.0016 17.9 0.0 2.1 2 0 0 2 2 2 1 AAA-like domain Miro PF08477.8 EFX02668.1 - 0.0005 20.5 0.0 0.0017 18.8 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 EFX02668.1 - 0.00062 18.9 1.2 0.0011 18.0 0.0 2.0 2 0 0 2 2 2 1 AIG1 family ABC_tran PF00005.22 EFX02668.1 - 0.0007 19.9 3.0 0.023 14.9 0.0 2.7 2 1 1 3 3 3 1 ABC transporter AAA_16 PF13191.1 EFX02668.1 - 0.0045 17.0 0.9 0.011 15.6 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX02668.1 - 0.0045 17.1 0.0 0.025 14.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EFX02668.1 - 0.0056 16.1 0.0 0.025 14.0 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.1 EFX02668.1 - 0.0079 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Ras PF00071.17 EFX02668.1 - 0.01 15.2 0.0 0.032 13.6 0.0 1.8 1 0 0 1 1 1 0 Ras family Phage_GPO PF05929.6 EFX02668.1 - 0.04 13.1 5.4 0.061 12.5 3.8 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ATP_bind_1 PF03029.12 EFX02668.1 - 0.058 12.9 0.4 6.5 6.2 0.0 2.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Sigma54_activat PF00158.21 EFX02668.1 - 0.087 12.3 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Exonuc_VII_L PF02601.10 EFX02668.1 - 0.11 11.7 4.9 0.22 10.7 3.4 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit RNA_helicase PF00910.17 EFX02668.1 - 0.14 12.3 0.1 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.18 EFX02668.1 - 0.14 11.9 8.4 0.73 9.6 0.1 3.4 2 2 0 3 3 3 0 Dynamin family MobB PF03205.9 EFX02668.1 - 0.14 11.8 1.7 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B YlqD PF11068.3 EFX02668.1 - 0.15 12.0 8.4 0.32 11.0 5.8 1.5 1 0 0 1 1 1 0 YlqD protein V_ATPase_I PF01496.14 EFX02668.1 - 3 5.5 8.9 4.7 4.9 6.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 EFX02668.1 - 7.3 6.1 8.5 13 5.2 5.9 1.4 1 0 0 1 1 1 0 IncA protein Asp PF00026.18 EFX02669.1 - 7.6e-70 235.6 4.9 9.5e-70 235.3 3.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX02669.1 - 7.4e-12 45.5 4.1 4.8e-11 42.8 0.6 2.5 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EFX02669.1 - 0.00099 18.6 0.1 0.0027 17.2 0.0 1.8 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EFX02669.1 - 0.0014 19.1 6.9 1.3 9.5 0.1 4.2 4 1 0 4 4 4 2 Aspartyl protease DND1_DSRM PF14709.1 EFX02670.1 - 7.4e-05 22.9 0.1 0.00016 21.8 0.1 1.6 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.20 EFX02670.1 - 0.00074 20.0 0.0 0.0016 19.0 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif PAP1 PF08601.5 EFX02671.1 - 3e-41 142.2 33.7 3.8e-25 89.3 10.3 3.2 3 0 0 3 3 3 2 Transcription factor PAP1 bZIP_1 PF00170.16 EFX02671.1 - 7.1e-08 32.3 9.1 1.3e-07 31.4 6.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX02671.1 - 0.022 14.5 10.6 0.066 13.0 7.3 1.8 1 1 0 1 1 1 0 Basic region leucine zipper DUF904 PF06005.7 EFX02671.1 - 0.12 12.6 1.7 0.23 11.8 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Adeno_PIX PF03955.9 EFX02671.1 - 0.19 12.2 0.2 0.19 12.2 0.2 3.1 3 0 0 3 3 3 0 Adenovirus hexon-associated protein (IX) ADIP PF11559.3 EFX02671.1 - 4.1 7.2 8.4 3.9 7.3 4.7 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding NAM-associated PF14303.1 EFX02671.1 - 6.5 7.0 16.4 0.74 10.1 8.0 1.8 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain AMP-binding PF00501.23 EFX02672.1 - 1.2e-20 73.3 1.9 2.2e-20 72.4 1.3 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_10 PF13460.1 EFX02673.1 - 9.1e-07 29.0 0.0 2.5e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFX02673.1 - 0.0025 17.1 0.0 0.005 16.1 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family SnoaL_2 PF12680.2 EFX02673.1 - 0.095 13.1 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain DUF1690 PF07956.6 EFX02674.1 - 5.3e-30 104.2 0.0 6.5e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Pkinase PF00069.20 EFX02676.1 - 1.2e-41 142.6 0.0 2.3e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02676.1 - 1.7e-20 73.2 0.0 3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Nup188 PF10487.4 EFX02676.1 - 3.1e-15 55.2 0.0 2.9e-09 35.4 0.0 2.9 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Kinase-like PF14531.1 EFX02676.1 - 0.041 12.8 0.0 0.088 11.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Rad10 PF03834.9 EFX02677.1 - 2.2e-30 104.1 0.0 3.2e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.1 EFX02677.1 - 0.00078 19.5 0.1 0.0021 18.1 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain FAD_binding_2 PF00890.19 EFX02678.1 - 3.3e-05 22.9 0.0 4e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 EFX02678.1 - 0.00014 21.8 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFX02678.1 - 0.00024 21.0 0.0 0.00033 20.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX02678.1 - 0.00055 18.9 0.0 0.00067 18.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFX02678.1 - 0.00098 18.2 0.0 0.0012 17.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EFX02678.1 - 0.0056 15.2 0.0 0.0069 14.8 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 EFX02678.1 - 0.012 14.6 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.17 EFX02678.1 - 0.039 12.8 0.0 0.046 12.5 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX02678.1 - 0.1 11.6 0.2 0.13 11.3 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFX02678.1 - 0.11 12.9 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EFX02678.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pkinase PF00069.20 EFX02679.1 - 6.5e-69 231.9 0.0 1.1e-68 231.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02679.1 - 9.4e-34 116.6 0.0 2.1e-33 115.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX02679.1 - 1.8e-05 23.8 0.2 0.00011 21.3 0.0 1.9 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 EFX02679.1 - 0.0077 15.3 0.2 0.02 13.9 0.2 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EFX02680.1 - 4.2e-69 232.5 0.0 5.4e-69 232.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02680.1 - 1.8e-32 112.4 0.0 2.7e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX02680.1 - 5.8e-06 25.4 0.0 8e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 EFX02680.1 - 0.00015 21.1 0.1 0.0034 16.7 0.0 2.8 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Kdo PF06293.9 EFX02680.1 - 0.00076 18.5 0.0 0.0014 17.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Homeobox PF00046.24 EFX02681.1 - 8.6e-10 38.0 0.3 5.2e-07 29.1 0.0 2.7 2 0 0 2 2 2 2 Homeobox domain Rhodanese PF00581.15 EFX02681.1 - 4.3e-08 33.4 0.0 1.2e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Oxidored_FMN PF00724.15 EFX02683.1 - 7.7e-88 294.7 0.0 9.9e-88 294.3 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family COPI_assoc PF08507.5 EFX02684.1 - 5e-45 152.5 10.7 7.9e-45 151.9 7.4 1.3 1 0 0 1 1 1 1 COPI associated protein Neurensin PF14927.1 EFX02684.1 - 3 7.2 4.4 28 4.0 2.7 2.4 1 1 1 2 2 2 0 Neurensin efThoc1 PF11957.3 EFX02685.1 - 4.1e-142 474.1 1.0 8.9e-142 473.0 0.7 1.6 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Aldo_ket_red PF00248.16 EFX02686.1 - 6.9e-65 218.6 0.0 7.8e-65 218.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Claudin_3 PF06653.6 EFX02686.1 - 0.18 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like RRM_6 PF14259.1 EFX02687.1 - 2.8e-39 132.9 0.0 8.3e-11 41.7 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX02687.1 - 8.6e-37 124.6 0.0 9.7e-12 44.3 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX02687.1 - 7.3e-20 70.5 0.0 5.2e-05 22.9 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM PF10378.4 EFX02687.1 - 2.6e-13 49.3 4.2 2.5e-12 46.1 2.9 2.8 1 0 0 1 1 1 1 Putative RRM domain RRM_3 PF08777.6 EFX02687.1 - 0.0017 18.1 4.3 0.018 14.9 0.1 2.8 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.1 EFX02687.1 - 0.017 14.8 0.0 11 5.8 0.0 3.2 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.6 EFX02687.1 - 0.023 14.6 0.0 0.21 11.6 0.0 2.5 3 0 0 3 3 3 0 RNA binding domain NID PF07292.8 EFX02687.1 - 0.12 12.4 0.0 0.57 10.2 0.0 2.1 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) Glycos_transf_2 PF00535.21 EFX02688.1 - 2.2e-22 79.5 0.0 3.9e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EFX02688.1 - 2.7e-08 33.9 1.5 5.5e-06 26.3 0.3 3.1 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Lipase_3 PF01764.20 EFX02689.1 - 2.2e-25 88.9 0.0 3.7e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EFX02689.1 - 0.0061 16.3 0.0 0.025 14.3 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX02689.1 - 0.094 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2974 PF11187.3 EFX02689.1 - 0.18 11.1 0.1 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Peptidase_C12 PF01088.16 EFX02690.1 - 4.2e-61 205.8 0.0 5.2e-61 205.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Glyoxalase PF00903.20 EFX02690.1 - 0.099 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HAUS2 PF15003.1 EFX02691.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 Rft-1 PF04506.8 EFX02692.1 - 7.3e-87 291.9 0.0 1e-86 291.5 0.0 1.1 1 0 0 1 1 1 1 Rft protein Diphthamide_syn PF01866.12 EFX02692.1 - 4.1e-52 177.3 0.0 5.6e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Hid1 PF12722.2 EFX02693.1 - 1.2e-238 794.2 0.0 2.8e-219 730.1 0.0 2.8 2 1 0 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 EFX02693.1 - 1.3e-79 268.1 0.0 1.2e-78 264.9 0.0 2.1 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein RIB43A PF05914.7 EFX02693.1 - 0.17 10.4 0.5 0.26 9.8 0.3 1.1 1 0 0 1 1 1 0 RIB43A CDC45 PF02724.9 EFX02693.1 - 0.26 9.2 6.5 0.39 8.6 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.10 EFX02693.1 - 0.26 10.7 7.8 0.48 9.9 5.4 1.4 1 0 0 1 1 1 0 Nucleoplasmin Daxx PF03344.10 EFX02693.1 - 0.6 8.5 10.1 0.91 7.9 7.0 1.3 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EFX02693.1 - 0.94 7.3 10.6 1.4 6.7 7.3 1.1 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.1 EFX02693.1 - 4.3 7.7 10.1 12 6.2 7.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.7 EFX02693.1 - 6 6.5 9.2 9 5.9 6.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.8 EFX02693.1 - 6.8 6.4 12.2 10 5.9 8.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SDA1 PF05285.7 EFX02693.1 - 6.9 5.8 9.9 10 5.2 6.9 1.1 1 0 0 1 1 1 0 SDA1 Cu_amine_oxid PF01179.15 EFX02695.1 - 3e-163 543.3 0.0 3.7e-163 543.0 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 EFX02695.1 - 1.1e-19 70.2 0.0 3e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 EFX02695.1 - 8.3e-17 61.0 0.1 3.3e-16 59.1 0.1 2.1 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain RINGv PF12906.2 EFX02695.1 - 0.13 12.3 0.1 7.7 6.6 0.0 2.5 2 0 0 2 2 2 0 RING-variant domain Aminotran_3 PF00202.16 EFX02696.1 - 1.2e-105 353.1 0.0 1.4e-105 352.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 EFX02696.1 - 0.00039 19.6 0.0 0.00072 18.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EFX02696.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Peptidase_S24 PF00717.18 EFX02699.1 - 3.3e-05 23.4 0.4 0.00027 20.4 0.3 2.2 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 EFX02699.1 - 0.021 14.3 0.0 0.45 10.0 0.0 2.2 1 1 1 2 2 2 0 Signal peptidase, peptidase S26 CFEM PF05730.6 EFX02700.1 - 0.0029 17.3 6.8 0.0079 15.9 4.7 1.7 1 0 0 1 1 1 1 CFEM domain ATP1G1_PLM_MAT8 PF02038.11 EFX02700.1 - 0.022 13.7 0.5 0.047 12.7 0.3 1.5 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family DUF869 PF05911.6 EFX02701.1 - 0.0001 20.7 16.6 0.00016 20.0 11.5 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) ADIP PF11559.3 EFX02701.1 - 0.0018 18.1 11.8 0.0018 18.1 8.2 2.8 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding DUF3037 PF11236.3 EFX02701.1 - 0.0026 17.7 1.2 0.0026 17.7 0.8 2.1 2 0 0 2 2 1 1 Protein of unknown function (DUF3037) WEMBL PF05701.6 EFX02701.1 - 0.0032 15.9 24.6 0.0032 15.9 17.1 1.6 2 0 0 2 2 2 1 Weak chloroplast movement under blue light Reo_sigmaC PF04582.7 EFX02701.1 - 0.0046 16.1 12.4 0.12 11.5 3.4 2.3 1 1 1 2 2 2 2 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 EFX02701.1 - 0.0054 14.5 22.4 0.0085 13.8 15.5 1.2 1 0 0 1 1 1 1 Myosin tail Herpes_UL36 PF03586.8 EFX02701.1 - 0.01 14.9 0.4 0.01 14.9 0.3 2.4 2 1 0 3 3 3 0 Herpesvirus UL36 tegument protein DMPK_coil PF08826.5 EFX02701.1 - 0.012 15.4 2.0 0.012 15.4 1.4 4.1 2 1 3 5 5 4 0 DMPK coiled coil domain like DUF236 PF03057.9 EFX02701.1 - 0.037 14.0 0.5 0.21 11.5 0.3 2.1 1 1 0 1 1 1 0 Protein of unknown function Atg14 PF10186.4 EFX02701.1 - 0.048 12.6 20.0 0.13 11.1 9.7 2.4 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Tropomyosin PF00261.15 EFX02701.1 - 0.048 12.7 23.1 0.01 14.9 13.1 1.9 1 1 0 1 1 1 0 Tropomyosin COG2 PF06148.6 EFX02701.1 - 0.081 12.7 12.7 0.37 10.6 3.9 2.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CCDC-167 PF15188.1 EFX02701.1 - 0.13 12.2 14.7 0.037 13.9 3.9 3.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Mod_r PF07200.8 EFX02701.1 - 0.24 11.3 23.0 0.83 9.5 3.5 3.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein IncA PF04156.9 EFX02701.1 - 0.27 10.8 27.4 0.16 11.5 11.7 2.8 1 1 1 2 2 2 0 IncA protein CENP-F_leu_zip PF10473.4 EFX02701.1 - 0.28 11.0 32.4 0.078 12.8 14.6 3.7 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Erp_C PF06780.6 EFX02701.1 - 0.43 10.4 13.1 0.75 9.6 3.2 3.0 1 1 1 2 2 2 0 Erp protein C-terminus Cytochrom_C_2 PF01322.15 EFX02701.1 - 0.49 10.9 6.9 1.7 9.2 1.5 2.8 1 1 1 2 2 2 0 Cytochrome C' Filament PF00038.16 EFX02701.1 - 0.56 9.6 22.8 3 7.2 8.3 2.6 1 1 1 2 2 2 0 Intermediate filament protein DUF1043 PF06295.7 EFX02701.1 - 0.62 9.7 11.6 3.6 7.2 2.9 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) CALCOCO1 PF07888.6 EFX02701.1 - 0.72 8.0 22.6 0.14 10.4 12.9 1.7 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like ATG16 PF08614.6 EFX02701.1 - 0.77 9.5 26.2 4.4 7.0 17.2 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) IFT57 PF10498.4 EFX02701.1 - 0.83 8.3 18.4 2.3 6.8 12.7 1.7 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 FlaC_arch PF05377.6 EFX02701.1 - 0.91 9.4 7.3 8.2 6.4 0.5 3.5 1 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Cluap1 PF10234.4 EFX02701.1 - 0.92 8.6 19.7 2.8 7.0 12.8 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 Spc7 PF08317.6 EFX02701.1 - 1.1 7.8 24.2 4.4 5.8 9.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4201 PF13870.1 EFX02701.1 - 1.3 8.4 22.8 1.1 8.6 5.8 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.7 EFX02701.1 - 1.5 8.5 29.2 3.4 7.4 5.0 3.3 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HrpB7 PF09486.5 EFX02701.1 - 2.5 7.9 17.0 2.4 8.0 0.6 3.1 2 1 1 3 3 2 0 Bacterial type III secretion protein (HrpB7) DUF1664 PF07889.7 EFX02701.1 - 3 7.6 13.9 1.9 8.2 3.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.7 EFX02701.1 - 3.3 7.4 17.5 3.1 7.5 1.1 3.3 1 1 2 3 3 3 0 Laminin Domain II APG6 PF04111.7 EFX02701.1 - 6.7 5.6 27.2 0.49 9.3 5.0 2.3 1 1 1 2 2 2 0 Autophagy protein Apg6 Seryl_tRNA_N PF02403.17 EFX02701.1 - 7.2 6.6 22.1 0.12 12.3 1.9 3.6 2 1 2 4 4 3 0 Seryl-tRNA synthetase N-terminal domain Lipoprotein_20 PF13942.1 EFX02701.1 - 7.3 6.0 16.1 1.8 8.1 1.3 3.0 1 1 2 3 3 3 0 YfhG lipoprotein S4 PF01479.20 EFX02702.1 - 1.7e-12 46.5 0.0 3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.14 EFX02702.1 - 1.8e-12 47.4 0.2 2.6e-12 46.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain F-box-like PF12937.2 EFX02703.1 - 2.2e-09 36.8 0.0 4.8e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX02703.1 - 1.2e-07 31.2 0.0 2.1e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 F-box domain UIM PF02809.15 EFX02703.1 - 1.9e-05 23.8 5.1 0.0026 17.1 0.1 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif Methyltransf_23 PF13489.1 EFX02704.1 - 1.4e-14 54.1 0.0 2.1e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02704.1 - 2.7e-08 34.3 0.0 3.1e-07 30.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02704.1 - 3.6e-07 29.8 0.0 8.1e-06 25.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02704.1 - 4.9e-05 23.7 0.0 0.00055 20.3 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 EFX02704.1 - 0.0017 18.3 0.0 0.0066 16.4 0.0 1.9 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 EFX02704.1 - 0.005 15.9 0.0 0.014 14.4 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX02704.1 - 0.0055 16.7 0.0 0.065 13.2 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX02704.1 - 0.024 13.7 0.0 0.16 11.0 0.0 2.2 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.9 EFX02704.1 - 0.028 13.8 0.0 0.18 11.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.1 EFX02704.1 - 0.048 14.0 0.0 0.17 12.2 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain WD40 PF00400.27 EFX02705.1 - 7.2e-27 92.2 10.5 1.2e-07 31.3 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat MTHFR PF02219.12 EFX02706.1 - 2.3e-106 355.0 0.0 3.2e-106 354.5 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase FAD_binding_4 PF01565.18 EFX02707.1 - 6.6e-24 83.9 1.1 1.2e-23 83.0 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX02707.1 - 0.00035 20.4 0.6 0.00084 19.1 0.4 1.7 1 0 0 1 1 1 1 Berberine and berberine like GPI-anchored PF10342.4 EFX02708.1 - 1.1e-21 77.1 3.5 1.1e-21 77.1 2.5 3.3 2 1 2 4 4 4 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.1 EFX02708.1 - 4.5e-05 23.0 0.3 7.7e-05 22.2 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Amidohydro_3 PF07969.6 EFX02708.1 - 0.0016 17.7 0.1 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family FAD_binding_1 PF00667.15 EFX02709.1 - 1.6e-25 89.8 0.0 1.8e-24 86.4 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.20 EFX02709.1 - 3.6e-17 62.6 0.0 1.8e-16 60.4 0.0 2.0 1 1 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EFX02709.1 - 1.6e-13 51.1 0.0 1.2e-09 38.7 0.0 2.5 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.2 EFX02709.1 - 0.18 11.1 0.0 0.79 9.1 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin domain eRF1_2 PF03464.10 EFX02710.1 - 1.5e-44 151.5 0.1 2.5e-44 150.8 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EFX02710.1 - 2e-39 134.3 0.4 4e-39 133.3 0.3 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 EFX02710.1 - 4.7e-28 97.3 0.0 8.8e-28 96.5 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 DUF1649 PF07855.7 EFX02711.1 - 1.2e-64 216.9 0.0 1.4e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1649) Pkinase PF00069.20 EFX02712.1 - 2.4e-71 239.9 0.1 4e-71 239.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02712.1 - 1.2e-53 181.8 0.1 1.9e-53 181.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 EFX02712.1 - 4.5e-23 81.4 0.1 2e-22 79.3 0.0 2.3 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.1 EFX02712.1 - 3.8e-08 32.6 0.0 7.2e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.1 EFX02712.1 - 1.3e-06 28.6 0.0 4.3e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain APH PF01636.18 EFX02712.1 - 0.0012 18.5 0.1 0.0055 16.4 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFX02712.1 - 0.022 13.6 0.0 0.037 12.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF501 PF04417.7 EFX02712.1 - 5.7 6.7 6.1 1.9 8.3 1.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF501) His_Phos_2 PF00328.17 EFX02713.1 - 1.5e-44 152.7 0.0 2.8e-44 151.8 0.0 1.4 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) adh_short PF00106.20 EFX02714.1 - 3.2e-28 98.7 3.4 4.3e-28 98.3 2.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX02714.1 - 1.1e-18 67.9 0.0 3.1e-18 66.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX02714.1 - 1.6e-11 44.1 3.5 3.8e-11 42.9 2.4 1.6 1 1 0 1 1 1 1 KR domain HHH_5 PF14520.1 EFX02714.1 - 0.073 13.2 0.1 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain Eno-Rase_NADH_b PF12242.3 EFX02714.1 - 0.18 11.5 1.1 0.54 10.0 0.8 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase MoCF_biosynth PF00994.19 EFX02715.1 - 3.5e-52 175.6 1.0 5.4e-30 103.6 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.12 EFX02715.1 - 5.4e-36 123.4 2.4 9.6e-36 122.5 1.7 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.10 EFX02715.1 - 1.7e-16 59.9 0.0 4.4e-16 58.5 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) SelP_N PF04592.9 EFX02715.1 - 1.1 8.6 7.1 1.6 8.0 4.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region WHIM1 PF15612.1 EFX02716.1 - 0.00023 20.9 0.9 0.0006 19.6 0.0 2.1 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Nop14 PF04147.7 EFX02716.1 - 0.071 11.0 29.3 0.12 10.2 20.3 1.3 1 0 0 1 1 1 0 Nop14-like family Trypan_PARP PF05887.6 EFX02716.1 - 0.72 9.6 14.7 1.7 8.4 10.2 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) eIF-3c_N PF05470.7 EFX02716.1 - 0.9 7.5 13.2 1.8 6.5 9.2 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Astro_capsid PF03115.9 EFX02716.1 - 1.7 6.8 6.9 2.3 6.3 4.8 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor SDA1 PF05285.7 EFX02716.1 - 2.1 7.5 28.9 3.8 6.6 20.0 1.4 1 0 0 1 1 1 0 SDA1 Daxx PF03344.10 EFX02716.1 - 2.7 6.3 30.2 0.047 12.1 16.2 1.5 2 0 0 2 2 2 0 Daxx Family BNIP2 PF12496.3 EFX02716.1 - 3.6 7.7 18.0 11 6.2 7.2 3.2 3 0 0 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 YL1 PF05764.8 EFX02716.1 - 6.3 6.3 35.2 0.016 14.8 14.2 2.7 3 0 0 3 3 3 0 YL1 nuclear protein CDC45 PF02724.9 EFX02716.1 - 7.9 4.3 21.8 15 3.4 15.1 1.3 1 0 0 1 1 1 0 CDC45-like protein zf-Tim10_DDP PF02953.10 EFX02717.1 - 5.2e-18 64.0 2.0 7.3e-18 63.6 1.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger KxDL PF10241.4 EFX02717.1 - 0.081 12.8 3.8 0.33 10.8 1.1 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF842 PF05811.8 EFX02717.1 - 0.13 11.6 4.7 0.33 10.4 3.3 1.7 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) RNase_P_Rpp14 PF01900.14 EFX02718.1 - 5.2e-35 119.5 0.0 6.8e-35 119.2 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Suf PF05843.9 EFX02719.1 - 1.6e-07 31.3 3.3 0.055 13.1 0.1 3.9 2 1 0 3 3 3 3 Suppressor of forked protein (Suf) TPR_16 PF13432.1 EFX02719.1 - 0.00059 20.4 10.4 0.00081 19.9 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX02719.1 - 0.0018 18.7 10.2 14 6.6 0.0 7.1 5 3 2 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFX02719.1 - 0.0082 16.4 0.0 0.72 10.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Gmad2 PF10648.4 EFX02719.1 - 0.047 13.8 0.2 0.46 10.6 0.1 2.5 2 1 1 3 3 3 0 Immunoglobulin-like domain of bacterial spore germination Ketoacyl-synt_C PF02801.17 EFX02720.1 - 7e-09 35.5 0.1 1.4e-08 34.6 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.21 EFX02720.1 - 1.1e-05 25.1 0.1 1.6e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Alpha_kinase PF02816.13 EFX02721.1 - 2e-41 141.7 0.0 2.3e-40 138.2 0.0 2.1 1 1 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 EFX02721.1 - 1.5e-08 34.9 0.3 3.1e-08 33.9 0.2 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EFX02721.1 - 1.5e-06 28.0 0.0 1.4e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain UPRTase PF14681.1 EFX02722.1 - 2.1e-78 262.2 0.0 2.4e-78 262.0 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EFX02722.1 - 5.3e-06 26.1 0.0 1e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain MetJ PF01340.15 EFX02722.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Met Apo-repressor, MetJ UCH_1 PF13423.1 EFX02723.1 - 2.7e-70 237.1 0.0 5.7e-70 236.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.24 EFX02723.1 - 3.6e-11 42.6 0.0 1.5e-10 40.6 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Aa_trans PF01490.13 EFX02724.1 - 5.9e-76 255.5 4.2 7e-76 255.3 2.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Sugar_tr PF00083.19 EFX02725.1 - 1.2e-132 442.7 33.4 1.4e-132 442.5 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX02725.1 - 3.1e-21 75.5 48.1 1.3e-12 47.1 13.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3605 PF12239.3 EFX02726.1 - 4e-54 182.7 0.0 4.8e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Ank_2 PF12796.2 EFX02727.1 - 1.7e-38 130.7 0.0 2.8e-17 62.8 0.0 2.8 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) zf-DHHC PF01529.15 EFX02727.1 - 1.9e-35 121.7 11.5 1.9e-35 121.7 7.9 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.25 EFX02727.1 - 1.3e-33 113.0 0.2 6.3e-08 32.0 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 EFX02727.1 - 1e-26 92.3 2.5 4.2e-08 33.1 0.0 5.2 2 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX02727.1 - 5.8e-24 84.0 0.7 2.4e-07 31.1 0.2 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX02727.1 - 1.8e-21 74.0 2.1 3.5e-07 29.8 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat P_C PF06640.6 EFX02727.1 - 0.005 16.8 0.7 0.01 15.8 0.5 1.5 1 0 0 1 1 1 1 P protein C-terminus Spo12 PF05032.7 EFX02728.1 - 7.2e-15 54.3 0.7 1.3e-14 53.4 0.5 1.5 1 0 0 1 1 1 1 Spo12 family AroM PF07302.6 EFX02728.1 - 0.08 12.2 0.0 0.085 12.1 0.0 1.0 1 0 0 1 1 1 0 AroM protein p450 PF00067.17 EFX02729.1 - 3.4e-69 233.5 0.0 4.5e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1467 PF07330.7 EFX02729.1 - 0.077 12.7 0.2 32 4.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1467) tRNA-synt_2 PF00152.15 EFX02730.1 - 6.5e-68 228.9 0.0 1.2e-67 228.0 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFX02730.1 - 1.7e-07 31.0 0.0 3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PFK PF00365.15 EFX02731.1 - 1.8e-162 538.9 1.7 1.6e-117 391.4 1.5 2.1 2 0 0 2 2 2 2 Phosphofructokinase PLDc_2 PF13091.1 EFX02733.1 - 6.2e-14 51.8 0.0 1e-05 25.3 0.0 3.4 3 1 0 3 3 3 2 PLD-like domain PLDc PF00614.17 EFX02733.1 - 1.7e-11 43.5 2.0 7.1e-05 22.4 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif FANCI_HD2 PF14680.1 EFX02733.1 - 0.043 12.9 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 FANCI helical domain 2 tRNA-synt_1d PF00750.14 EFX02734.1 - 1.5e-65 221.3 4.1 8.2e-63 212.3 2.8 2.7 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 EFX02734.1 - 3.4e-27 94.7 0.0 1.1e-26 93.1 0.0 2.0 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 EFX02734.1 - 3.6e-05 24.2 0.0 0.00012 22.5 0.0 2.0 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain Iso_dh PF00180.15 EFX02736.1 - 7.5e-97 324.3 0.0 8.5e-97 324.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Rifin_STEVOR PF02009.11 EFX02737.1 - 6.2 6.3 6.4 8.1 5.9 4.4 1.1 1 0 0 1 1 1 0 Rifin/stevor family Sporozoite_P67 PF05642.6 EFX02737.1 - 7 4.3 18.3 9.3 3.9 12.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen G-patch_2 PF12656.2 EFX02738.1 - 2.1e-22 78.7 0.2 2.1e-22 78.7 0.2 3.2 3 2 1 4 4 4 1 DExH-box splicing factor binding site MIP PF00230.15 EFX02739.1 - 4.4e-55 186.6 9.1 5.2e-55 186.3 6.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF92 PF01940.11 EFX02740.1 - 7.2e-65 218.3 0.0 1.6e-64 217.1 0.0 1.5 1 1 0 1 1 1 1 Integral membrane protein DUF92 SNF2_N PF00176.18 EFX02741.1 - 5.2e-66 222.4 0.0 7e-66 222.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX02741.1 - 1.6e-11 43.9 0.0 8.3e-11 41.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 EFX02741.1 - 2.2e-05 24.1 9.2 6.6e-05 22.6 6.4 1.9 1 0 0 1 1 1 1 Ring finger domain HIRAN PF08797.6 EFX02741.1 - 0.00012 21.9 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain zf-RING_5 PF14634.1 EFX02741.1 - 0.00021 20.9 9.6 0.00045 19.8 6.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFX02741.1 - 0.0021 17.6 9.8 0.0065 16.1 6.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFX02741.1 - 0.0055 16.7 4.3 0.014 15.5 3.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EFX02741.1 - 0.076 13.0 10.3 0.4 10.7 7.2 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX02741.1 - 0.094 12.3 9.5 0.22 11.1 6.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Syja_N PF02383.13 EFX02742.1 - 2.5e-84 282.7 0.0 4.2e-84 282.0 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 EFX02742.1 - 1.1e-20 74.6 0.1 1.9e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HAD_2 PF13419.1 EFX02743.1 - 4.3e-33 115.0 0.3 5.2e-33 114.7 0.2 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX02743.1 - 8.6e-07 28.5 0.0 1.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EFX02743.1 - 0.00025 21.5 0.0 0.0011 19.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.2 EFX02743.1 - 0.0022 17.6 0.0 0.12 12.0 0.0 2.1 2 0 0 2 2 2 1 Acid Phosphatase Glyco_hydro_81 PF03639.8 EFX02744.1 - 1.2e-169 565.5 0.0 1.9e-169 564.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 DnaJ PF00226.26 EFX02744.1 - 6e-19 67.5 0.4 1.1e-18 66.7 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain Stn1 PF10451.4 EFX02744.1 - 4e-10 38.9 0.0 1.4e-09 37.1 0.0 1.7 1 1 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.20 EFX02744.1 - 0.0007 19.4 0.1 0.0013 18.5 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain LMBR1 PF04791.11 EFX02744.1 - 0.1 11.1 0.3 0.15 10.6 0.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Bromo_TP PF07524.8 EFX02745.1 - 7.4e-16 57.6 0.1 1.3e-15 56.8 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.4 EFX02745.1 - 8.7e-10 38.5 12.4 4.6e-06 26.5 1.3 3.9 4 0 0 4 4 4 2 Transcription factor TFIID complex subunit 8 C-term Peptidase_C12 PF01088.16 EFX02746.1 - 2.2e-47 160.9 0.0 3e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Prenyltransf PF01255.14 EFX02747.1 - 4.8e-06 25.8 0.0 0.00034 19.8 0.0 2.2 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase ketoacyl-synt PF00109.21 EFX02748.1 - 7.1e-67 225.5 0.3 1.5e-66 224.5 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX02748.1 - 5.9e-54 183.5 0.1 1.5e-53 182.2 0.1 1.7 1 0 0 1 1 1 1 Acyl transferase domain PP-binding PF00550.20 EFX02748.1 - 3.6e-10 39.9 0.0 8.8e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ketoacyl-synt_C PF02801.17 EFX02748.1 - 2.1e-06 27.5 0.0 6e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 EFX02748.1 - 4.6e-06 25.8 0.0 9e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_5 PF12695.2 EFX02748.1 - 0.015 15.0 0.5 0.1 12.3 0.1 2.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family LRR_4 PF12799.2 EFX02749.1 - 0.00068 19.2 13.1 0.64 9.7 2.1 5.4 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX02749.1 - 0.00083 19.0 10.3 0.0057 16.3 0.7 5.2 4 1 2 6 6 6 3 Leucine rich repeat LRR_1 PF00560.28 EFX02749.1 - 0.025 14.5 16.7 44 4.6 0.3 9.0 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_6 PF13516.1 EFX02749.1 - 7.8 6.9 28.5 51 4.3 0.0 9.3 11 0 0 11 11 11 0 Leucine Rich repeat FA_hydroxylase PF04116.8 EFX02750.1 - 1.3e-16 60.9 11.2 1.3e-16 60.9 7.8 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TFIIS_C PF01096.13 EFX02751.1 - 1.7e-16 59.5 2.7 1.7e-16 59.5 1.9 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 EFX02751.1 - 0.00011 21.7 7.7 0.00018 21.1 2.2 2.5 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit zinc_ribbon_2 PF13240.1 EFX02751.1 - 0.00023 20.5 9.9 0.88 9.1 0.1 3.7 4 0 0 4 4 4 3 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EFX02751.1 - 0.0025 17.0 7.4 1.7 8.0 0.0 3.4 2 1 1 3 3 3 2 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.6 EFX02751.1 - 0.0071 15.9 12.4 0.088 12.4 2.2 2.4 2 1 0 2 2 2 2 Putative transposase DNA-binding domain DZR PF12773.2 EFX02751.1 - 0.0078 16.0 10.3 0.029 14.1 1.4 2.5 3 0 0 3 3 2 2 Double zinc ribbon Lar_restr_allev PF14354.1 EFX02751.1 - 0.015 15.5 12.0 0.015 15.5 0.6 3.1 2 1 0 2 2 2 0 Restriction alleviation protein Lar PAS PF00989.19 EFX02751.1 - 0.042 13.6 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 PAS fold Zn-ribbon_8 PF09723.5 EFX02751.1 - 0.064 13.2 13.2 0.33 10.9 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain HypA PF01155.14 EFX02751.1 - 0.084 12.5 8.3 0.57 9.8 0.6 2.5 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-C2HC_2 PF13913.1 EFX02751.1 - 0.14 11.8 1.2 0.14 11.8 0.8 2.8 4 0 0 4 4 3 0 zinc-finger of a C2HC-type PAAR_motif PF05488.8 EFX02751.1 - 0.19 11.7 1.9 3.4 7.7 0.1 2.4 2 1 0 2 2 2 0 PAAR motif zf-ribbon_3 PF13248.1 EFX02751.1 - 0.26 10.5 0.1 0.26 10.5 0.1 3.3 3 1 1 4 4 4 0 zinc-ribbon domain IBR PF01485.16 EFX02751.1 - 0.74 9.7 8.1 4 7.3 0.5 2.4 2 1 0 2 2 2 0 IBR domain FdhE PF04216.7 EFX02751.1 - 1.5 8.4 6.9 0.11 12.1 0.4 1.9 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation Zn_Tnp_IS91 PF14319.1 EFX02751.1 - 1.8 8.0 10.2 3 7.3 1.6 2.3 1 1 0 2 2 2 0 Transposase zinc-binding domain Nudix_N_2 PF14803.1 EFX02751.1 - 1.9 8.2 16.4 0.47 10.1 4.7 3.2 3 1 0 3 3 3 0 Nudix N-terminal GFA PF04828.9 EFX02751.1 - 2.1 8.3 13.0 22 5.0 0.1 3.1 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Cytochrom_c3_2 PF14537.1 EFX02751.1 - 5.9 7.2 8.8 1.5 9.2 3.8 1.7 1 1 1 2 2 2 0 Cytochrome c3 zf-C2HC5 PF06221.8 EFX02751.1 - 7 6.4 9.0 3.1 7.6 1.1 2.6 3 0 0 3 3 2 0 Putative zinc finger motif, C2HC5-type DUF2082 PF09855.4 EFX02751.1 - 9.6 6.1 8.3 0.85 9.5 0.3 2.7 3 0 0 3 3 3 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DUF1922 PF09082.5 EFX02751.1 - 9.8 6.3 9.3 38 4.4 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1922) ParA PF10609.4 EFX02752.1 - 4.3e-35 119.4 0.0 7.6e-35 118.6 0.0 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EFX02752.1 - 6.1e-15 55.1 0.0 8.7e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EFX02752.1 - 3.6e-05 23.7 0.0 0.00014 21.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 EFX02752.1 - 0.0003 19.9 0.1 0.0028 16.7 0.0 2.1 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.6 EFX02752.1 - 0.0023 17.0 0.0 0.0054 15.8 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ DUF258 PF03193.11 EFX02752.1 - 0.0048 16.1 0.0 0.0086 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_26 PF13500.1 EFX02752.1 - 0.0092 15.6 0.0 3.3 7.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFX02752.1 - 0.019 14.3 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zn_Tnp_IS1595 PF12760.2 EFX02752.1 - 0.023 14.4 0.1 0.094 12.5 0.1 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Rad17 PF03215.10 EFX02752.1 - 0.028 13.1 0.0 0.04 12.5 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 EFX02752.1 - 0.068 12.9 0.2 1.2 8.9 0.0 2.5 2 1 0 2 2 2 0 Part of AAA domain RNA_helicase PF00910.17 EFX02752.1 - 0.095 12.8 0.1 0.23 11.6 0.0 1.6 1 1 0 1 1 1 0 RNA helicase SRP54 PF00448.17 EFX02752.1 - 0.12 11.8 0.0 0.34 10.3 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.1 EFX02752.1 - 0.13 12.4 0.0 0.34 11.0 0.0 1.7 2 0 0 2 2 1 0 AAA domain T2SE PF00437.15 EFX02752.1 - 0.19 10.6 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein HGTP_anticodon2 PF12745.2 EFX02753.1 - 7.7e-70 235.1 0.0 1.6e-68 230.8 0.0 2.6 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.20 EFX02753.1 - 4.5e-68 229.2 0.0 9.7e-37 126.5 0.0 4.1 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02753.1 - 2.6e-40 138.1 0.0 2.6e-19 69.3 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 EFX02753.1 - 7.4e-17 61.2 0.0 1.7e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 RWD domain APH PF01636.18 EFX02753.1 - 3.1e-05 23.8 4.9 0.089 12.5 0.0 3.3 3 0 0 3 3 3 2 Phosphotransferase enzyme family zf-CCCH PF00642.19 EFX02754.1 - 1.8e-08 33.8 17.9 2.8e-07 30.0 1.5 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 EFX02754.1 - 1.1e-05 25.1 0.0 1.8e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX02754.1 - 0.0013 18.3 0.0 0.0027 17.3 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SCRG1 PF15224.1 EFX02754.1 - 0.079 12.7 2.7 1.3 8.9 0.1 2.4 2 0 0 2 2 2 0 Scrapie-responsive protein 1 Tachystatin_B PF11478.3 EFX02754.1 - 4.2 7.1 11.9 0.16 11.7 2.1 2.7 2 1 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B NAD_binding_10 PF13460.1 EFX02755.1 - 2.3e-07 30.9 0.6 1.5e-06 28.3 0.4 2.0 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFX02755.1 - 1.4e-05 24.4 0.1 4.6e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 EFX02755.1 - 0.00069 19.1 0.0 0.0012 18.3 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFX02755.1 - 0.0029 16.5 0.4 2.1 7.2 0.0 2.7 2 1 1 3 3 3 2 Male sterility protein SlyX PF04102.7 EFX02756.1 - 1.1 9.6 4.7 11 6.5 0.3 2.8 2 0 0 2 2 2 0 SlyX COX5A PF02284.11 EFX02757.1 - 5e-40 135.8 0.6 6.3e-40 135.5 0.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DHC_N1 PF08385.7 EFX02757.1 - 0.12 10.7 0.2 1.3 7.3 0.0 1.9 1 1 1 2 2 2 0 Dynein heavy chain, N-terminal region 1 ketoacyl-synt PF00109.21 EFX02758.1 - 2e-67 227.3 0.2 2e-67 227.3 0.1 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.1 EFX02758.1 - 2.1e-66 224.0 8.8 6.4e-66 222.5 6.1 1.9 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 EFX02758.1 - 3.4e-56 190.8 4.4 7e-56 189.8 3.1 1.6 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EFX02758.1 - 2.9e-50 170.4 6.1 2e-49 167.6 4.3 2.7 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 EFX02758.1 - 4.5e-42 143.7 7.0 4.5e-42 143.7 4.8 4.3 3 0 0 3 3 3 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFX02758.1 - 6.3e-37 126.0 0.4 6.3e-37 126.0 0.3 2.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.7 EFX02758.1 - 7.6e-21 74.4 0.1 2.8e-18 66.2 0.0 3.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX02758.1 - 6.7e-14 51.9 0.0 2.2e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02758.1 - 1.4e-10 41.5 0.1 6.3e-10 39.4 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02758.1 - 2.5e-09 37.6 0.1 4.1e-08 33.8 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02758.1 - 9.2e-06 25.3 0.0 2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.20 EFX02758.1 - 1.5e-05 25.1 0.3 4.1e-05 23.7 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.13 EFX02758.1 - 5.8e-05 22.3 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_zinc_N PF00107.21 EFX02758.1 - 0.0013 18.2 0.2 0.039 13.5 0.0 3.5 3 0 0 3 3 3 1 Zinc-binding dehydrogenase 3Beta_HSD PF01073.14 EFX02758.1 - 0.0041 15.8 0.0 0.0069 15.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family MTS PF05175.9 EFX02758.1 - 0.03 13.6 0.0 0.12 11.7 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase small domain DUF1971 PF09313.6 EFX02758.1 - 0.05 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) DNA_gyraseB_C PF00986.16 EFX02758.1 - 0.23 11.2 0.0 0.52 10.0 0.0 1.5 1 0 0 1 1 1 0 DNA gyrase B subunit, carboxyl terminus DUF915 PF06028.6 EFX02758.1 - 3.9 6.4 0.0 6.9 5.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Snf7 PF03357.16 EFX02759.1 - 4.1e-36 123.9 17.4 4.1e-36 123.9 12.1 1.3 2 0 0 2 2 2 1 Snf7 V_ATPase_I PF01496.14 EFX02759.1 - 0.0084 14.0 1.7 0.01 13.7 1.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CaMBD PF02888.11 EFX02759.1 - 0.032 14.0 1.2 0.032 14.0 0.8 1.9 2 0 0 2 2 2 0 Calmodulin binding domain DUF4309 PF14172.1 EFX02759.1 - 0.1 12.5 0.1 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4309) Ist1 PF03398.9 EFX02759.1 - 0.15 11.4 5.5 0.27 10.6 3.8 1.4 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DFF40 PF09230.5 EFX02759.1 - 0.81 9.0 3.6 1.1 8.6 2.5 1.2 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa PspA_IM30 PF04012.7 EFX02759.1 - 0.91 8.8 15.9 2.2 7.5 3.3 2.1 1 1 0 2 2 2 0 PspA/IM30 family GPI2 PF06432.6 EFX02760.1 - 3.5e-114 380.9 0.2 6.3e-113 376.8 0.0 2.0 2 0 0 2 2 2 2 Phosphatidylinositol N-acetylglucosaminyltransferase Ank_5 PF13857.1 EFX02761.1 - 6.8e-14 51.5 0.7 5.5e-09 35.9 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX02761.1 - 2.6e-13 50.1 0.1 2.9e-05 24.3 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX02761.1 - 2e-11 43.1 3.7 1.3e-06 27.9 0.3 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 EFX02761.1 - 9.4e-07 28.4 0.2 0.024 14.8 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 EFX02761.1 - 2e-06 28.1 0.8 0.0069 16.8 0.1 2.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Porphobil_deamC PF03900.10 EFX02761.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Porphobilinogen deaminase, C-terminal domain UPF0546 PF10639.4 EFX02762.1 - 3.9e-36 123.2 0.1 1.6e-35 121.3 0.1 1.7 1 1 0 1 1 1 1 Uncharacterised protein family UPF0546 EamA PF00892.15 EFX02762.1 - 0.17 11.9 5.3 0.63 10.0 2.9 2.1 2 0 0 2 2 2 0 EamA-like transporter family PetM PF08041.6 EFX02762.1 - 0.69 9.4 3.4 1.8 8.1 2.4 1.7 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 CPSase_L_D3 PF02787.14 EFX02763.1 - 0.062 13.0 0.1 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ECM11 PF15463.1 EFX02764.1 - 1.8e-42 144.8 4.4 1.8e-42 144.8 3.1 2.8 3 0 0 3 3 3 1 Extracellular mutant protein 11 NACHT PF05729.7 EFX02765.1 - 6.5e-05 22.6 0.1 0.00015 21.4 0.1 1.6 2 0 0 2 2 2 1 NACHT domain DUF3278 PF11683.3 EFX02765.1 - 0.46 10.4 1.9 1.6 8.7 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3278) NmrA PF05368.8 EFX02766.1 - 9.3e-74 247.5 0.0 1.2e-73 247.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX02766.1 - 0.0004 20.4 0.1 0.0087 16.0 0.1 2.2 1 1 0 1 1 1 1 NADH(P)-binding XRN_N PF03159.13 EFX02767.1 - 3.6e-101 337.5 0.0 6.9e-101 336.5 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus COesterase PF00135.23 EFX02769.1 - 2.8e-52 178.1 0.0 3.7e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX02769.1 - 2.1e-06 27.5 0.1 0.043 13.3 0.1 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold NUDIX PF00293.23 EFX02770.1 - 9.6e-16 57.6 0.5 1.9e-15 56.6 0.1 1.6 2 0 0 2 2 2 1 NUDIX domain SelB-wing_3 PF09107.6 EFX02770.1 - 0.046 13.1 0.0 0.15 11.4 0.0 1.8 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Oxysterol_BP PF01237.13 EFX02771.1 - 2e-101 339.0 0.0 5.3e-101 337.6 0.0 1.7 3 0 0 3 3 3 1 Oxysterol-binding protein DNA_pol_E_B PF04042.11 EFX02771.1 - 5.3e-63 212.0 0.0 3.3e-62 209.4 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B PH_8 PF15409.1 EFX02771.1 - 4.7e-36 122.7 0.4 1.9e-35 120.8 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 EFX02771.1 - 0.0014 18.7 0.0 0.0035 17.5 0.0 1.7 1 0 0 1 1 1 1 PH domain Troponin-I_N PF11636.3 EFX02771.1 - 0.063 12.9 2.0 0.29 10.8 1.4 2.2 1 0 0 1 1 1 0 Troponin I residues 1-32 PH_11 PF15413.1 EFX02771.1 - 0.15 12.3 0.9 0.91 9.7 0.5 2.5 2 1 0 2 2 2 0 Pleckstrin homology domain SLS PF14611.1 EFX02772.1 - 8.3e-28 97.2 0.0 1.9e-27 96.0 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator BAR_2 PF10455.4 EFX02773.1 - 4.1e-57 193.3 0.9 6.3e-57 192.6 0.6 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 EFX02773.1 - 7.2e-18 64.9 2.2 7.2e-17 61.6 1.6 2.2 1 1 0 1 1 1 1 BAR domain LSM PF01423.17 EFX02773.1 - 1.9e-13 49.7 0.0 4.1e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 LSM domain PPR_3 PF13812.1 EFX02773.1 - 1.4e-09 37.4 2.8 0.0052 16.9 0.0 6.3 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_2 PF13041.1 EFX02773.1 - 0.00016 21.5 0.0 3.9 7.5 0.0 4.8 5 1 0 5 5 5 2 PPR repeat family PPR PF01535.15 EFX02773.1 - 0.0014 18.5 0.1 3.1 7.9 0.0 4.7 3 0 0 3 3 3 1 PPR repeat P63C PF10546.4 EFX02773.1 - 0.098 12.6 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 P63C domain DUF663 PF04950.7 EFX02774.1 - 2.9e-86 289.1 0.0 4.6e-86 288.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EFX02774.1 - 1.7e-27 94.7 0.0 7.8e-27 92.6 0.0 2.1 2 0 0 2 2 2 1 AARP2CN (NUC121) domain AAA_16 PF13191.1 EFX02774.1 - 9.4e-06 25.7 1.9 1.6e-05 24.9 0.0 2.4 3 0 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX02774.1 - 1.6e-05 25.0 0.0 5.4e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 EFX02774.1 - 4.3e-05 23.0 0.0 0.007 15.8 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.24 EFX02774.1 - 0.00044 20.4 0.1 0.0014 18.8 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EFX02774.1 - 0.00047 19.8 0.0 0.0011 18.6 0.0 1.7 1 1 0 1 1 1 1 NACHT domain ABC_tran PF00005.22 EFX02774.1 - 0.00061 20.0 0.2 0.0038 17.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_19 PF13245.1 EFX02774.1 - 0.001 18.8 0.5 0.0043 16.7 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain MMR_HSR1 PF01926.18 EFX02774.1 - 0.0011 18.8 0.0 0.0047 16.8 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFX02774.1 - 0.0012 19.3 0.0 0.0043 17.5 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AAA_14 PF13173.1 EFX02774.1 - 0.0016 18.3 0.1 0.0084 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EFX02774.1 - 0.002 17.8 0.1 0.0063 16.2 0.0 1.9 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 EFX02774.1 - 0.0022 17.4 0.0 0.0063 16.0 0.0 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 EFX02774.1 - 0.0031 18.3 0.0 0.0031 18.3 0.0 4.5 3 1 0 4 4 2 1 AAA domain AAA_25 PF13481.1 EFX02774.1 - 0.0036 16.7 0.0 0.013 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX02774.1 - 0.0061 16.8 0.0 0.0061 16.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 EFX02774.1 - 0.0069 16.2 1.1 0.023 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 EFX02774.1 - 0.0095 15.3 0.1 0.024 14.0 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 EFX02774.1 - 0.015 15.0 0.1 0.034 13.8 0.1 1.6 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.1 EFX02774.1 - 0.016 14.8 0.0 0.038 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFX02774.1 - 0.026 14.6 0.0 0.057 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.17 EFX02774.1 - 0.034 13.0 0.0 0.067 12.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF258 PF03193.11 EFX02774.1 - 0.047 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Fungal_trans PF04082.13 EFX02775.1 - 0.00039 19.3 0.0 0.00062 18.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.11 EFX02776.1 - 3.6e-27 94.9 35.4 3.6e-27 94.9 24.6 2.6 4 0 0 4 4 4 1 Major Facilitator Superfamily Nucleopor_Nup85 PF07575.8 EFX02776.1 - 3.9e-07 28.6 0.1 0.00064 18.0 0.0 3.1 3 0 0 3 3 3 3 Nup85 Nucleoporin cIII PF08134.6 EFX02776.1 - 0.013 15.1 0.2 0.44 10.1 0.1 2.7 2 0 0 2 2 2 0 cIII protein family MR_MLE_C PF13378.1 EFX02777.1 - 1.1e-18 67.2 0.2 3.7e-18 65.5 0.1 2.0 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE PF01188.16 EFX02777.1 - 1.8e-12 47.5 0.3 4.8e-12 46.2 0.0 1.9 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 EFX02777.1 - 0.0042 17.0 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.6 EFX02777.1 - 0.014 14.3 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus FAD_binding_8 PF08022.7 EFX02778.1 - 3.9e-15 55.6 0.0 9.3e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EFX02778.1 - 5.8e-13 49.0 0.0 9.4e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EFX02778.1 - 2.1e-11 43.9 12.8 2.1e-11 43.9 8.9 2.1 2 1 0 2 2 2 1 Ferric reductase like transmembrane component HDA2-3 PF11496.3 EFX02779.1 - 5e-06 25.5 0.0 0.00011 21.0 0.0 2.4 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Chromo PF00385.19 EFX02779.1 - 0.00068 19.2 0.1 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Reo_sigmaC PF04582.7 EFX02779.1 - 4.6 6.3 9.7 0.27 10.3 1.8 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF775 PF05603.7 EFX02779.1 - 8.6 5.8 7.3 0.54 9.7 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Sec2p PF06428.6 EFX02780.1 - 2.5e-09 36.9 20.1 7.5e-09 35.3 8.2 2.9 2 1 1 3 3 3 2 GDP/GTP exchange factor Sec2p IncA PF04156.9 EFX02780.1 - 0.0016 18.0 19.8 0.019 14.5 9.6 2.2 2 0 0 2 2 2 2 IncA protein SlyX PF04102.7 EFX02780.1 - 0.091 13.1 0.1 0.091 13.1 0.0 4.2 3 1 1 4 4 4 0 SlyX UvrD-helicase PF00580.16 EFX02780.1 - 0.53 9.5 8.7 0.9 8.7 6.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain IGPS PF00218.16 EFX02781.1 - 3e-97 324.6 0.0 5.1e-97 323.9 0.0 1.4 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.23 EFX02781.1 - 4.4e-50 169.7 0.0 7.7e-50 169.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I PRAI PF00697.17 EFX02781.1 - 4.9e-46 156.7 0.0 1.8e-41 141.8 0.0 2.6 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Peptidase_C26 PF07722.8 EFX02781.1 - 8.8e-06 25.3 0.1 3.4e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 TUG-UBL1 PF11470.3 EFX02782.1 - 1.6e-19 69.5 0.0 3.2e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 GLUT4 regulating protein TUG UBX PF00789.15 EFX02782.1 - 0.004 17.1 0.0 0.014 15.4 0.0 2.0 1 0 0 1 1 1 1 UBX domain CLU_N PF15044.1 EFX02782.1 - 0.06 13.4 0.2 4.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial function, CLU-N-term S4 PF01479.20 EFX02783.1 - 1.9e-15 55.9 0.0 4.4e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.1 EFX02783.1 - 0.053 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 S4 domain Herpes_capsid PF06112.6 EFX02783.1 - 0.8 9.7 7.7 0.08 12.9 2.4 1.6 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Med3 PF11593.3 EFX02783.1 - 2 7.5 8.5 3.5 6.7 5.9 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal bZIP_1 PF00170.16 EFX02784.1 - 0.02 14.8 8.3 0.039 13.9 5.4 1.6 1 1 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.10 EFX02784.1 - 0.37 10.6 10.5 0.34 10.7 5.6 2.1 1 1 1 2 2 2 0 Basic region leucine zipper AflR PF08493.5 EFX02785.1 - 1.1e-09 37.7 0.1 1.1e-09 37.7 0.1 3.2 1 1 1 3 3 3 1 Aflatoxin regulatory protein Sec63 PF02889.11 EFX02787.1 - 1.6e-138 461.1 0.0 1.8e-91 306.6 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EFX02787.1 - 1.1e-51 174.6 0.0 2.6e-27 95.3 0.1 3.5 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX02787.1 - 2.8e-16 59.1 0.0 6.6e-07 29.0 0.0 3.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.10 EFX02787.1 - 1.7e-13 50.8 0.0 2.8e-05 24.0 0.0 3.0 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFX02787.1 - 8.3e-07 29.2 0.1 0.11 12.5 0.1 3.5 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EFX02787.1 - 2.2e-06 27.3 0.3 0.057 13.1 0.0 3.7 3 0 0 3 3 3 2 Part of AAA domain IstB_IS21 PF01695.12 EFX02787.1 - 0.01 15.2 0.1 21 4.4 0.0 4.3 5 0 0 5 5 5 0 IstB-like ATP binding protein MMR_HSR1 PF01926.18 EFX02788.1 - 3.9e-09 36.4 0.1 2.2e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFX02788.1 - 9.2e-08 31.4 0.0 2.3e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 EFX02788.1 - 4.6e-06 25.8 0.7 0.017 14.2 0.0 2.8 3 0 0 3 3 3 2 AIG1 family Septin PF00735.13 EFX02788.1 - 0.00035 19.6 0.2 0.0013 17.8 0.1 1.9 1 1 0 1 1 1 1 Septin FtsK_SpoIIIE PF01580.13 EFX02788.1 - 0.00074 19.0 0.0 0.0021 17.5 0.0 1.7 1 0 0 1 1 1 1 FtsK/SpoIIIE family Dynamin_N PF00350.18 EFX02788.1 - 0.0011 18.8 2.0 0.01 15.6 0.6 3.0 2 1 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 EFX02788.1 - 0.0018 17.7 0.0 0.0051 16.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain T2SE PF00437.15 EFX02788.1 - 0.0018 17.2 0.1 0.0042 16.0 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein IIGP PF05049.8 EFX02788.1 - 0.0052 15.6 0.0 0.012 14.4 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.1 EFX02788.1 - 0.0062 16.0 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFX02788.1 - 0.015 15.2 0.0 0.015 15.2 0.0 3.8 4 0 0 4 4 4 0 AAA ATPase domain MobB PF03205.9 EFX02788.1 - 0.016 14.9 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EFX02788.1 - 0.016 14.6 0.6 0.05 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain DUF87 PF01935.12 EFX02788.1 - 0.02 14.7 1.2 0.074 12.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF87 Sigma54_activat PF00158.21 EFX02788.1 - 0.029 13.8 0.0 0.062 12.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.1 EFX02788.1 - 0.031 14.3 0.1 0.4 10.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_17 PF13207.1 EFX02788.1 - 0.033 15.0 0.0 0.56 11.0 0.0 2.9 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EFX02788.1 - 0.039 14.2 0.2 0.24 11.7 0.0 2.4 2 1 1 3 3 2 0 ABC transporter DUF2205 PF10224.4 EFX02788.1 - 0.044 13.3 0.1 0.49 9.9 0.0 2.6 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) AAA_33 PF13671.1 EFX02788.1 - 0.046 13.5 0.3 0.64 9.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 EFX02788.1 - 0.051 13.7 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Miro PF08477.8 EFX02788.1 - 0.061 13.8 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein AAA_23 PF13476.1 EFX02788.1 - 0.16 12.2 8.4 4.2 7.6 5.9 2.5 1 1 0 1 1 1 0 AAA domain TENA_THI-4 PF03070.11 EFX02790.1 - 0.0055 16.4 0.4 0.0055 16.4 0.3 2.2 3 0 0 3 3 3 1 TENA/THI-4/PQQC family CorA PF01544.13 EFX02790.1 - 0.99 8.3 7.5 0.11 11.4 1.4 2.1 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein APG6 PF04111.7 EFX02790.1 - 2.6 6.9 54.2 0.55 9.2 9.8 3.4 2 1 0 3 3 3 0 Autophagy protein Apg6 Abhydrolase_6 PF12697.2 EFX02792.1 - 1.2e-17 64.6 10.0 3.5e-17 63.0 6.9 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX02792.1 - 5.4e-11 42.4 0.2 2.1e-10 40.5 0.1 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX02792.1 - 0.001 18.6 0.1 0.0032 17.0 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFX02792.1 - 0.0016 18.2 0.1 0.0045 16.8 0.0 1.8 1 0 0 1 1 1 1 Putative lysophospholipase DUF2048 PF09752.4 EFX02792.1 - 0.074 11.9 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Prenyltrans PF00432.16 EFX02793.1 - 8.9e-33 111.5 25.3 8.6e-09 34.8 0.2 6.2 5 1 1 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EFX02793.1 - 9.1e-20 71.1 1.8 1.1e-09 38.7 0.1 4.6 2 2 3 5 5 5 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 EFX02793.1 - 0.0014 18.5 0.8 0.017 15.1 0.0 2.6 2 1 0 2 2 2 1 Prenyltransferase-like APH PF01636.18 EFX02794.1 - 1.2e-05 25.2 0.2 0.0042 16.8 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EFX02794.1 - 1.4e-05 24.2 0.1 2.6e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFX02794.1 - 0.0054 16.3 0.0 0.38 10.2 0.0 2.1 1 1 1 2 2 2 2 Choline/ethanolamine kinase RIO1 PF01163.17 EFX02794.1 - 0.017 14.5 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.20 EFX02794.1 - 0.071 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain FTA4 PF13093.1 EFX02798.1 - 1.1e-51 175.3 0.0 1.4e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2462 PF09495.5 EFX02798.1 - 1.8e-06 28.6 8.7 1.8e-06 28.6 6.0 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) DivIC PF04977.10 EFX02798.1 - 0.099 12.1 0.2 0.5 9.8 0.2 2.1 2 0 0 2 2 2 0 Septum formation initiator Curto_V3 PF07436.6 EFX02798.1 - 3.8 7.7 4.4 27 4.9 0.0 2.7 2 0 0 2 2 2 0 Curtovirus V3 protein UQ_con PF00179.21 EFX02799.1 - 6.7e-47 158.4 0.0 7.6e-47 158.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX02799.1 - 0.00021 21.0 0.0 0.00028 20.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 EFX02799.1 - 0.0058 16.2 0.1 0.012 15.3 0.1 1.6 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 EFX02799.1 - 0.054 13.3 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain MFS_1 PF07690.11 EFX02800.1 - 6.6e-37 127.0 32.3 6.6e-37 127.0 22.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02800.1 - 4.2e-12 45.3 11.4 4.2e-12 45.3 7.9 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFX02800.1 - 3e-07 29.0 2.4 4.4e-07 28.4 1.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AAA PF00004.24 EFX02801.1 - 2.5e-28 98.9 0.0 1.1e-20 74.1 0.0 3.3 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFX02801.1 - 1.9e-05 25.4 0.0 5.3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFX02801.1 - 0.0005 19.5 1.5 0.023 14.1 0.0 2.9 2 1 1 3 3 2 1 AAA domain AAA_22 PF13401.1 EFX02801.1 - 0.00052 20.1 0.0 0.002 18.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.12 EFX02801.1 - 0.00058 18.8 0.0 0.00094 18.1 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_16 PF13191.1 EFX02801.1 - 0.00071 19.6 3.6 0.01 15.8 0.1 4.2 4 1 0 4 4 3 1 AAA ATPase domain IstB_IS21 PF01695.12 EFX02801.1 - 0.0011 18.3 0.0 0.0023 17.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.7 EFX02801.1 - 0.0016 17.5 0.0 0.0037 16.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFX02801.1 - 0.002 17.8 0.3 0.015 14.9 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain Mg_chelatase PF01078.16 EFX02801.1 - 0.015 14.4 0.0 0.043 12.9 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EFX02801.1 - 0.015 15.4 0.0 0.065 13.4 0.0 2.2 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.1 EFX02801.1 - 0.016 15.1 0.2 0.06 13.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_2 PF07724.9 EFX02801.1 - 0.021 14.7 0.0 2 8.3 0.0 2.3 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) KaiC PF06745.8 EFX02801.1 - 0.034 13.2 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 KaiC PhoH PF02562.11 EFX02801.1 - 0.044 13.0 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.1 EFX02801.1 - 0.047 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EFX02801.1 - 0.06 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFX02801.1 - 0.078 12.7 0.0 0.26 10.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF815 PF05673.8 EFX02801.1 - 0.12 11.2 0.0 0.27 10.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TIP49 PF06068.8 EFX02801.1 - 0.34 9.5 0.0 0.54 8.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus PPV_E1_C PF00519.12 EFX02801.1 - 0.47 9.0 0.0 0.77 8.3 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase F-box-like PF12937.2 EFX02802.1 - 0.073 12.8 0.4 0.19 11.4 0.3 1.7 1 0 0 1 1 1 0 F-box-like WD40 PF00400.27 EFX02805.1 - 2.2e-14 52.6 15.9 2e-07 30.6 0.2 5.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Apt1 PF10351.4 EFX02805.1 - 2 7.1 2.1 4.3 6.0 1.5 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain RNB PF00773.14 EFX02806.1 - 2.9e-60 204.2 0.0 4.5e-60 203.6 0.0 1.2 1 0 0 1 1 1 1 RNB domain DUF3543 PF12063.3 EFX02807.1 - 4.7e-85 284.6 0.0 7.1e-85 284.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 EFX02807.1 - 1.4e-54 184.9 0.0 2.6e-54 184.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02807.1 - 1.8e-36 125.5 0.0 4.4e-36 124.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EFX02807.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.1 EFX02807.1 - 0.15 11.0 0.0 0.36 9.7 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Ribosomal_L2_C PF03947.13 EFX02808.1 - 1.3e-37 128.4 3.7 2e-37 127.8 2.6 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EFX02808.1 - 8.5e-14 51.2 0.1 1.7e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain UCH PF00443.24 EFX02809.1 - 5.7e-43 146.9 0.0 1e-42 146.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.26 EFX02809.1 - 4.3e-23 80.4 4.2 3.9e-11 42.4 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.14 EFX02809.1 - 4.5e-22 77.9 11.8 1.4e-18 66.7 1.0 3.5 3 1 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 EFX02809.1 - 4.3e-19 69.0 0.0 1.7e-17 63.8 0.0 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2180 PF09947.4 EFX02809.1 - 0.79 9.5 6.5 21 4.9 0.0 4.3 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) MFS_1 PF07690.11 EFX02810.1 - 6.7e-24 84.2 52.2 1.4e-13 50.3 16.4 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX02810.1 - 3e-12 45.8 29.9 4e-07 28.9 9.7 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.1 EFX02810.1 - 0.00058 18.3 7.0 0.00058 18.3 4.8 2.9 3 2 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.2 EFX02810.1 - 0.0084 15.8 2.0 1.8 8.4 0.2 2.8 2 0 0 2 2 2 2 MFS_1 like family Aminotran_MocR PF12897.2 EFX02810.1 - 0.16 10.5 0.0 0.24 9.8 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase MNHE PF01899.11 EFX02810.1 - 0.19 11.3 5.2 3.1 7.4 0.0 2.9 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit PgaD PF13994.1 EFX02810.1 - 0.61 9.5 4.3 2.7 7.4 0.4 2.9 3 0 0 3 3 3 0 PgaD-like protein DUF3040 PF11239.3 EFX02810.1 - 5.5 7.1 6.7 1.3 9.0 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3040) Exo_endo_phos PF03372.18 EFX02812.1 - 6.2e-11 42.6 0.4 9.7e-11 42.0 0.3 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Fungal_trans PF04082.13 EFX02813.1 - 5e-22 78.0 0.0 7.7e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02813.1 - 4.3e-08 32.9 10.7 7e-08 32.2 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2OG-FeII_Oxy PF03171.15 EFX02814.1 - 0.00058 20.1 0.0 0.0016 18.7 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 EFX02814.1 - 0.00066 20.1 0.1 0.0012 19.2 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.13 EFX02815.1 - 1.2e-08 34.6 14.7 2e-08 33.9 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF706 PF05153.10 EFX02816.1 - 2.6e-124 413.5 0.2 3.6e-124 413.1 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF706) ABC_tran PF00005.22 EFX02817.1 - 5.7e-45 152.9 0.1 1e-24 87.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFX02817.1 - 1.2e-44 152.8 30.4 2.7e-25 89.3 4.2 3.9 3 1 1 4 4 4 3 ABC transporter transmembrane region AAA_16 PF13191.1 EFX02817.1 - 3e-05 24.1 0.6 0.0034 17.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.1 EFX02817.1 - 6.7e-05 22.9 0.3 6.6 6.6 0.1 3.5 3 0 0 3 3 3 0 AAA domain Miro PF08477.8 EFX02817.1 - 0.0002 21.8 0.9 0.044 14.2 0.0 2.6 2 0 0 2 2 2 1 Miro-like protein AAA_25 PF13481.1 EFX02817.1 - 0.0021 17.4 0.1 0.13 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EFX02817.1 - 0.0059 16.5 1.6 0.9 9.5 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.1 EFX02817.1 - 0.0061 16.0 1.5 0.24 10.9 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_19 PF13245.1 EFX02817.1 - 0.012 15.3 0.5 0.053 13.2 0.2 2.2 2 0 0 2 2 2 0 Part of AAA domain AAA_10 PF12846.2 EFX02817.1 - 0.017 14.5 0.0 1.6 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain ArgK PF03308.11 EFX02817.1 - 0.02 13.6 2.5 2.5 6.8 0.0 2.4 2 0 0 2 2 2 0 ArgK protein Zeta_toxin PF06414.7 EFX02817.1 - 0.022 13.8 0.3 0.19 10.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin DUF258 PF03193.11 EFX02817.1 - 0.041 13.0 2.1 0.62 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_30 PF13604.1 EFX02817.1 - 0.043 13.3 1.6 2.4 7.7 0.3 2.7 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 EFX02817.1 - 0.046 13.2 0.0 4.1 6.8 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.14 EFX02817.1 - 0.11 11.9 0.4 0.23 10.8 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.1 EFX02817.1 - 0.11 13.3 2.1 2.5 8.9 0.6 2.9 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 EFX02817.1 - 0.18 11.9 0.8 2.1 8.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.14 EFX02817.1 - 0.27 10.4 4.7 4.4 6.4 0.0 3.2 3 1 1 4 4 4 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFX02817.1 - 0.35 11.1 2.1 0.38 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EFX02817.1 - 0.69 8.7 3.0 3.1 6.5 0.4 2.2 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.9 EFX02817.1 - 0.72 9.5 2.5 2.4 7.8 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 EFX02817.1 - 0.99 9.0 3.8 0.42 10.2 0.3 2.0 2 0 0 2 2 2 0 NACHT domain DUF87 PF01935.12 EFX02817.1 - 3.8 7.2 6.8 15 5.3 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 Dynamin_N PF00350.18 EFX02817.1 - 3.9 7.2 5.4 0.48 10.2 0.3 2.0 2 0 0 2 2 2 0 Dynamin family Na_Ca_ex PF01699.19 EFX02818.1 - 1e-44 151.5 33.9 1.8e-23 82.6 6.5 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein PIF1 PF05970.9 EFX02820.1 - 2e-56 191.4 0.1 3.9e-42 144.4 0.0 2.3 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 EFX02820.1 - 5.5e-14 52.2 0.0 1.2e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX02820.1 - 1e-07 32.1 0.0 2.3e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX02820.1 - 1.2e-05 24.9 0.1 3.5e-05 23.4 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA PF00004.24 EFX02820.1 - 1.4e-05 25.3 0.0 4.1e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.1 EFX02820.1 - 2.7e-05 24.2 0.0 0.00012 22.1 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.1 EFX02820.1 - 0.00029 20.8 0.2 0.002 18.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Herpes_Helicase PF02689.9 EFX02820.1 - 0.00031 18.6 0.1 0.00075 17.3 0.0 1.5 2 0 0 2 2 2 1 Helicase AAA_5 PF07728.9 EFX02820.1 - 0.0031 17.2 0.4 0.052 13.2 0.1 2.7 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 EFX02820.1 - 0.006 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.11 EFX02820.1 - 0.0073 15.5 0.0 0.019 14.2 0.0 1.7 1 0 0 1 1 1 1 PhoH-like protein AAA_11 PF13086.1 EFX02820.1 - 0.017 14.7 0.3 1.1 8.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EFX02820.1 - 0.019 14.8 0.0 0.067 13.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFX02820.1 - 0.021 15.1 0.0 0.12 12.6 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 EFX02820.1 - 0.021 14.3 0.0 0.066 12.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 EFX02820.1 - 0.027 13.8 0.0 0.063 12.7 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain NACHT PF05729.7 EFX02820.1 - 0.033 13.8 0.0 0.072 12.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.18 EFX02820.1 - 0.042 13.7 0.0 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase Sigma54_activat PF00158.21 EFX02820.1 - 0.065 12.7 0.0 0.17 11.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.17 EFX02820.1 - 0.078 11.8 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 EFX02820.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF815 PF05673.8 EFX02820.1 - 0.11 11.3 0.1 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF2075 PF09848.4 EFX02820.1 - 0.12 11.3 0.0 0.26 10.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Pkinase PF00069.20 EFX02821.1 - 1.5e-31 109.4 0.0 3.1e-16 59.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02821.1 - 8e-16 57.8 0.0 5.7e-08 32.1 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase DUF788 PF05620.6 EFX02822.1 - 4.3e-44 150.3 0.1 4.8e-44 150.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) 5-FTHF_cyc-lig PF01812.15 EFX02823.1 - 2.2e-10 40.6 0.0 2.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family DUF4243 PF14027.1 EFX02824.1 - 1.5e-28 100.2 0.3 1.9e-28 99.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) Fcf1 PF04900.7 EFX02825.1 - 2.1e-14 53.3 0.0 5e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 Fcf1 DUF4149 PF13664.1 EFX02826.1 - 1.1e-19 70.3 3.3 1.1e-19 70.3 2.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1772 PF08592.6 EFX02826.1 - 0.25 11.0 2.4 0.8 9.4 0.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Hat1_N PF10394.4 EFX02827.1 - 4.8e-40 137.2 0.0 8.1e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus CDV3 PF15359.1 EFX02827.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 AAA PF00004.24 EFX02828.1 - 6.3e-57 191.4 0.0 1.6e-41 141.6 0.0 3.3 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX02828.1 - 1.7e-09 37.8 0.3 3.6e-05 23.8 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX02828.1 - 3.3e-09 37.0 5.5 0.0057 16.6 0.1 4.4 2 2 2 4 4 4 2 AAA ATPase domain NACHT PF05729.7 EFX02828.1 - 5.2e-08 32.7 1.4 0.0038 16.9 0.2 4.2 3 1 1 4 4 4 1 NACHT domain AAA_5 PF07728.9 EFX02828.1 - 5.4e-08 32.6 0.1 0.012 15.2 0.0 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFX02828.1 - 1.4e-05 25.0 0.1 0.18 11.6 0.0 4.2 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.1 EFX02828.1 - 2.6e-05 23.6 4.9 2.3 7.5 0.1 4.3 2 2 2 4 4 4 3 AAA domain AAA_28 PF13521.1 EFX02828.1 - 3.4e-05 23.8 0.5 0.2 11.6 0.0 3.8 4 1 1 5 5 5 2 AAA domain AAA_17 PF13207.1 EFX02828.1 - 0.0001 23.0 0.0 0.11 13.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EFX02828.1 - 0.00011 21.4 0.1 0.43 9.7 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 EFX02828.1 - 0.00022 21.0 0.0 0.31 10.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.7 EFX02828.1 - 0.00026 20.0 0.0 0.02 13.9 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFX02828.1 - 0.00036 20.2 0.5 0.079 12.7 0.0 3.2 3 0 0 3 3 3 1 Part of AAA domain AAA_18 PF13238.1 EFX02828.1 - 0.00084 19.6 0.0 0.014 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EFX02828.1 - 0.003 17.7 0.0 2.7 8.2 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.1 EFX02828.1 - 0.0044 16.8 0.0 1.8 8.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 EFX02828.1 - 0.0048 16.6 0.2 0.32 10.6 0.0 3.3 3 1 1 4 4 4 1 NTPase Sigma54_activ_2 PF14532.1 EFX02828.1 - 0.011 15.7 0.1 2.1 8.3 0.0 3.0 2 1 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 EFX02828.1 - 0.011 14.8 0.0 2.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin UPF0079 PF02367.12 EFX02828.1 - 0.011 15.3 0.1 0.13 11.9 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 IstB_IS21 PF01695.12 EFX02828.1 - 0.014 14.8 0.0 3.2 7.1 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Rad17 PF03215.10 EFX02828.1 - 0.017 13.8 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Sigma54_activat PF00158.21 EFX02828.1 - 0.027 13.9 0.0 3.8 6.9 0.0 3.1 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.1 EFX02828.1 - 0.038 13.5 0.0 4.6 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 EFX02828.1 - 0.059 12.9 0.0 0.75 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.4 EFX02828.1 - 0.082 11.8 0.0 1 8.1 0.0 2.6 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.22 EFX02828.1 - 0.14 12.4 0.1 0.76 10.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter KaiC PF06745.8 EFX02828.1 - 0.2 10.7 3.0 15 4.6 0.1 3.2 2 1 1 3 3 3 0 KaiC DLH PF01738.13 EFX02829.1 - 1.2e-14 54.0 0.0 1.4e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFX02829.1 - 0.00044 20.0 0.0 0.00066 19.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Glyco_hydro_16 PF00722.16 EFX02830.1 - 7.4e-41 139.4 3.5 1.1e-40 138.8 2.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 BolA PF01722.13 EFX02831.1 - 8e-15 54.5 0.0 1.3e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 BolA-like protein PP1c_bdg PF10488.4 EFX02831.1 - 0.054 12.6 0.4 0.069 12.3 0.3 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region Glyco_tranf_2_3 PF13641.1 EFX02832.1 - 3.3e-26 92.5 1.1 5.2e-26 91.8 0.8 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFX02832.1 - 4.8e-19 68.8 10.2 4.8e-19 68.8 7.0 3.0 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 EFX02832.1 - 8.2e-19 67.5 0.0 1.3e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EFX02832.1 - 4.8e-17 62.1 0.0 7.2e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_hydro_12 PF01670.11 EFX02832.1 - 1.5e-09 37.8 0.1 3.4e-09 36.6 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Cellulose_synt PF03552.9 EFX02832.1 - 1.5e-06 26.8 2.3 0.0014 17.0 0.9 2.2 2 0 0 2 2 2 2 Cellulose synthase Glyco_tranf_2_2 PF10111.4 EFX02832.1 - 0.08 12.0 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Pmp3 PF01679.12 EFX02834.1 - 6.7e-27 92.9 5.9 7.4e-27 92.8 4.1 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Pectate_lyase PF03211.8 EFX02836.1 - 1.2e-64 217.6 6.0 1.5e-64 217.3 4.1 1.0 1 0 0 1 1 1 1 Pectate lyase Mpp10 PF04006.7 EFX02837.1 - 3.7e-84 283.2 54.6 4.7e-82 276.2 37.8 2.5 1 1 0 1 1 1 1 Mpp10 protein S-AdoMet_synt_C PF02773.11 EFX02838.1 - 3.7e-76 253.4 0.1 6.3e-76 252.7 0.1 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 EFX02838.1 - 1.4e-47 160.5 0.0 2.5e-47 159.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 EFX02838.1 - 2.4e-41 139.9 0.6 4.8e-41 139.0 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain DUF2312 PF10073.4 EFX02838.1 - 0.073 12.4 0.4 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) zf-C2H2 PF00096.21 EFX02839.1 - 1.3 9.5 8.8 2.3 8.7 0.4 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX02839.1 - 8.9 6.9 13.8 3.1 8.3 1.0 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger SRP54 PF00448.17 EFX02840.1 - 4.7e-06 26.1 0.0 7e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.1 EFX02840.1 - 1.8e-05 24.4 3.6 0.37 10.5 0.0 3.4 3 0 0 3 3 3 2 Part of AAA domain AAA_17 PF13207.1 EFX02840.1 - 6.1e-05 23.8 0.0 0.00024 21.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX02840.1 - 7.9e-05 22.7 1.2 0.004 17.1 0.8 2.4 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 EFX02840.1 - 0.00035 20.2 0.0 0.00096 18.8 0.0 1.7 1 1 0 1 1 1 1 NACHT domain ArgK PF03308.11 EFX02840.1 - 0.0015 17.3 0.0 0.0026 16.6 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_18 PF13238.1 EFX02840.1 - 0.011 15.9 0.0 0.038 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 EFX02840.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 EFX02840.1 - 0.014 15.0 0.2 0.023 14.4 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA_31 PF13614.1 EFX02840.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.10 EFX02840.1 - 0.017 14.1 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase KAP_NTPase PF07693.9 EFX02840.1 - 0.018 14.0 0.0 0.044 12.7 0.0 1.5 2 0 0 2 2 2 0 KAP family P-loop domain AAA PF00004.24 EFX02840.1 - 0.028 14.6 0.0 0.076 13.2 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFX02840.1 - 0.028 14.2 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EFX02840.1 - 0.033 13.2 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 EFX02840.1 - 0.039 13.3 0.3 3 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EFX02840.1 - 0.054 13.7 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 EFX02840.1 - 0.068 12.7 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EFX02840.1 - 0.071 12.8 0.1 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Thymidylate_kin PF02223.12 EFX02840.1 - 0.1 11.9 0.1 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase NB-ARC PF00931.17 EFX02840.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain UreE_C PF05194.7 EFX02840.1 - 2.3 8.3 8.9 5.8 7.0 6.2 1.7 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain dCMP_cyt_deam_1 PF00383.17 EFX02841.1 - 6e-11 41.9 0.0 8.7e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 EFX02841.1 - 0.014 14.9 0.0 0.016 14.8 0.0 1.1 1 0 0 1 1 1 0 APOBEC-like N-terminal domain L31 PF09784.4 EFX02842.1 - 1.6e-30 105.2 0.7 1.7e-30 105.1 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 ATP-synt_ab PF00006.20 EFX02843.1 - 2.8e-114 380.0 0.0 3.7e-114 379.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EFX02843.1 - 3.3e-18 66.1 0.2 5.8e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EFX02843.1 - 2.7e-14 53.0 3.6 7.2e-14 51.7 2.3 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain UQ_con PF00179.21 EFX02844.1 - 6.1e-51 171.5 0.0 6.9e-51 171.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX02844.1 - 2.3e-07 30.6 0.0 2.7e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFX02844.1 - 0.021 14.7 0.1 0.037 13.9 0.1 1.6 1 1 0 1 1 1 0 RWD domain Fungal_trans PF04082.13 EFX02845.1 - 1.9e-16 59.7 1.3 1.9e-16 59.6 0.2 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF1237 PF06824.6 EFX02846.1 - 1.3e-160 534.6 0.0 2.5e-90 303.1 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1237) ACBP PF00887.14 EFX02847.1 - 2.2e-24 84.9 0.5 2.6e-24 84.7 0.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein PSK_trans_fac PF07704.6 EFX02847.1 - 0.016 15.8 0.0 0.056 14.1 0.0 1.7 2 0 0 2 2 2 0 Rv0623-like transcription factor Pkinase PF00069.20 EFX02848.1 - 2.2e-43 148.2 0.0 5.1e-42 143.8 0.0 2.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02848.1 - 5.2e-25 87.9 0.0 1.9e-24 86.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Methyltransf_12 PF08242.7 EFX02850.1 - 0.00031 21.1 0.0 0.00059 20.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX02850.1 - 0.00083 19.1 0.0 0.0016 18.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02850.1 - 0.0015 18.9 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02850.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain 2OG-FeII_Oxy_3 PF13640.1 EFX02851.1 - 0.037 14.5 0.1 0.13 12.8 0.1 1.9 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily RNA_pol_L_2 PF13656.1 EFX02852.1 - 1.4e-29 101.3 0.0 2e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 EFX02852.1 - 3e-10 39.0 0.0 4.1e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain UPF0160 PF03690.8 EFX02852.1 - 0.059 12.7 0.0 0.059 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) Prothymosin PF03247.9 EFX02852.1 - 0.29 11.3 15.0 0.21 11.7 9.2 1.5 2 0 0 2 2 2 0 Prothymosin/parathymosin family Peptidase_C48 PF02902.14 EFX02853.1 - 3.4e-33 115.1 0.0 1.5e-32 112.9 0.0 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Pigment_DH PF06324.6 EFX02854.1 - 0.27 10.5 3.8 4.2 6.7 0.2 2.3 2 0 0 2 2 2 0 Pigment-dispersing hormone (PDH) AMP-binding PF00501.23 EFX02856.1 - 7.4e-89 298.0 0.0 8.7e-89 297.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX02856.1 - 7.5e-11 42.8 0.1 2e-10 41.4 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RrnaAD PF00398.15 EFX02857.1 - 4.7e-40 137.2 0.0 6.1e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 EFX02857.1 - 9.1e-06 25.7 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02857.1 - 0.081 13.5 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Formyl_trans_N PF00551.14 EFX02858.1 - 1.6e-22 79.9 0.0 8.3e-22 77.5 0.0 2.0 1 1 1 2 2 2 1 Formyl transferase GTP1_OBG PF01018.17 EFX02859.1 - 2.3e-35 121.5 1.8 1.2e-26 93.2 2.1 2.4 2 0 0 2 2 2 2 GTP1/OBG Nol1_Nop2_Fmu PF01189.12 EFX02859.1 - 8.2e-28 97.5 0.0 5.2e-18 65.4 0.0 4.5 2 1 1 3 3 3 3 NOL1/NOP2/sun family MMR_HSR1 PF01926.18 EFX02859.1 - 1.4e-20 73.4 0.0 3.4e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX02859.1 - 1.5e-06 27.6 0.1 3.6e-05 23.0 0.0 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B Methyltransf_26 PF13659.1 EFX02859.1 - 0.0045 17.0 0.1 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain ABC_tran PF00005.22 EFX02859.1 - 0.087 13.1 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Arf PF00025.16 EFX02859.1 - 0.15 11.3 0.0 0.77 8.9 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family FtsJ PF01728.14 EFX02859.1 - 0.2 11.6 0.0 0.51 10.3 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase A_deaminase PF00962.17 EFX02860.1 - 2.2e-20 72.8 0.0 3.9e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase MCM PF00493.18 EFX02861.1 - 3.7e-141 469.7 0.1 4.8e-141 469.3 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EFX02861.1 - 2.2e-19 70.1 0.4 9.1e-19 68.1 0.3 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EFX02861.1 - 9.3e-07 28.2 0.0 0.00021 20.5 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EFX02861.1 - 2.2e-05 24.1 0.0 4.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EFX02861.1 - 0.00082 18.9 0.0 0.0028 17.2 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EFX02861.1 - 0.037 13.4 0.0 1.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.24 EFX02861.1 - 0.079 13.1 0.0 0.34 11.1 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) F-box-like PF12937.2 EFX02862.1 - 1.8e-07 30.7 0.9 3.8e-07 29.7 0.6 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 EFX02862.1 - 0.019 14.5 0.5 4.3 7.0 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) F-box PF00646.28 EFX02862.1 - 0.29 10.8 7.4 2.6 7.8 5.1 2.4 1 1 0 1 1 1 0 F-box domain PfkB PF00294.19 EFX02863.1 - 1.5e-58 198.3 3.3 1.7e-58 198.1 2.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EFX02863.1 - 0.0047 16.1 0.1 0.0093 15.1 0.1 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase F_bP_aldolase PF01116.15 EFX02863.1 - 0.011 14.8 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II tRNA-synt_2b PF00587.20 EFX02864.1 - 1.9e-67 226.1 0.1 3.2e-67 225.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFX02864.1 - 3.6e-21 74.8 0.0 1.1e-20 73.3 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain CLAG PF03805.8 EFX02864.1 - 0.22 8.8 0.0 0.32 8.2 0.0 1.1 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein DUF21 PF01595.15 EFX02864.1 - 0.27 10.4 0.6 0.43 9.8 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF21 Sec5 PF15469.1 EFX02865.1 - 6.6e-34 117.2 0.0 4.8e-33 114.4 0.0 2.2 1 1 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.6 EFX02865.1 - 7.2e-05 22.5 0.1 0.00083 19.1 0.0 2.7 2 0 0 2 2 2 1 Vps51/Vps67 FlgN PF05130.7 EFX02865.1 - 0.58 10.4 13.1 0.32 11.2 5.6 2.8 2 0 0 2 2 2 0 FlgN protein Zn_clus PF00172.13 EFX02866.1 - 3.8e-06 26.6 9.4 7.1e-06 25.8 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX02866.1 - 0.002 17.0 0.0 0.0037 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TFIIA PF03153.8 EFX02866.1 - 2.2 8.0 6.1 5.8 6.7 4.3 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit dCMP_cyt_deam_1 PF00383.17 EFX02867.1 - 5.1e-13 48.5 0.2 2.2e-11 43.3 0.2 2.1 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 EFX02867.1 - 1.2e-08 34.9 0.9 4e-06 26.8 0.1 2.8 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.1 EFX02867.1 - 0.00016 21.1 1.2 0.023 14.0 0.0 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases YwqJ-deaminase PF14431.1 EFX02867.1 - 0.068 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 YwqJ-like deaminase PP2C PF00481.16 EFX02868.1 - 8.2e-60 202.3 0.1 1.7e-48 165.2 0.1 3.1 2 1 1 3 3 3 2 Protein phosphatase 2C Macoilin PF09726.4 EFX02868.1 - 4.8 5.3 6.1 6 5.0 4.3 1.3 1 0 0 1 1 1 0 Transmembrane protein adh_short PF00106.20 EFX02869.1 - 5.1e-20 72.0 0.8 7.1e-20 71.5 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX02869.1 - 3.3e-08 33.4 0.1 4.2e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFX02869.1 - 2e-07 31.0 0.0 2.6e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EFX02869.1 - 0.00051 19.5 0.0 0.00075 19.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX02869.1 - 0.002 18.1 0.0 0.0054 16.7 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX02869.1 - 0.028 13.1 0.0 0.036 12.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Proteasome PF00227.21 EFX02870.1 - 4.3e-48 163.1 0.0 5.5e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFX02870.1 - 2.8e-12 45.7 0.1 2.8e-12 45.7 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature ADH_zinc_N PF00107.21 EFX02872.1 - 1.9e-08 33.9 0.0 3.7e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX02872.1 - 0.00013 21.7 0.0 0.00037 20.2 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EFX02872.1 - 0.011 16.6 0.0 0.024 15.5 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Complex1_LYR PF05347.10 EFX02874.1 - 7.1e-07 28.9 0.1 1.7e-06 27.7 0.1 1.6 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFX02874.1 - 1.3e-05 25.2 0.3 2.2e-05 24.5 0.2 1.5 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 EFX02874.1 - 0.0028 18.0 0.0 0.0036 17.7 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like SH3BGR PF04908.10 EFX02875.1 - 0.00014 21.7 0.0 0.0006 19.7 0.0 1.9 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein SecD-TM1 PF13721.1 EFX02875.1 - 0.085 13.1 1.0 0.57 10.4 0.0 2.0 2 0 0 2 2 2 0 SecD export protein N-terminal TM region MCM PF00493.18 EFX02877.1 - 4e-87 292.0 3.1 6.3e-48 163.2 0.0 2.7 2 1 1 3 3 3 2 MCM2/3/5 family MCM2_N PF12619.3 EFX02877.1 - 5.5e-31 107.6 34.3 1.2e-30 106.6 23.7 1.6 1 0 0 1 1 1 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 EFX02877.1 - 7.9e-21 74.7 0.0 1.7e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.9 EFX02877.1 - 0.0081 15.8 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) zf-TFIIB PF13453.1 EFX02877.1 - 0.12 11.5 1.1 0.26 10.5 0.8 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger Zn_ribbon_2 PF12674.2 EFX02877.1 - 0.18 12.1 0.5 0.58 10.5 0.3 1.8 1 0 0 1 1 1 0 Putative zinc ribbon domain Got1 PF04178.7 EFX02879.1 - 3.8e-18 65.7 12.4 4.4e-18 65.4 8.6 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family YrhK PF14145.1 EFX02879.1 - 0.015 14.9 2.5 0.045 13.4 1.7 1.8 1 0 0 1 1 1 0 YrhK-like protein SAP PF02037.22 EFX02882.1 - 2.1e-12 46.2 0.6 3.3e-12 45.6 0.4 1.3 1 0 0 1 1 1 1 SAP domain SPC22 PF04573.7 EFX02883.1 - 3.8e-30 104.3 0.2 1.7e-21 76.2 0.0 2.1 2 0 0 2 2 2 2 Signal peptidase subunit Frag1 PF10277.4 EFX02885.1 - 1.5e-11 44.1 8.6 5.6e-10 39.0 0.5 4.0 2 2 1 3 3 3 2 Frag1/DRAM/Sfk1 family Alpha-amylase PF00128.19 EFX02886.1 - 4.6e-99 331.7 0.1 6.2e-99 331.3 0.1 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 EFX02886.1 - 0.05 12.5 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme Methyltransf_2 PF00891.13 EFX02887.1 - 2e-20 72.9 0.0 1.8e-14 53.5 0.0 2.1 1 1 1 2 2 2 2 O-methyltransferase DIOX_N PF14226.1 EFX02888.1 - 5.5e-21 75.2 0.0 9.5e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX02888.1 - 5.1e-11 42.7 0.0 1.3e-10 41.3 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PAP_central PF04928.12 EFX02889.1 - 5.8e-14 51.5 0.0 1.6e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Poly(A) polymerase central domain DUF504 PF04457.7 EFX02889.1 - 2.5e-11 43.5 0.2 5e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF504) PAP_RNA-bind PF04926.10 EFX02889.1 - 0.00023 20.6 0.0 0.00058 19.4 0.0 1.7 2 0 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain SHR3_chaperone PF08229.6 EFX02889.1 - 0.065 12.1 0.5 0.12 11.3 0.4 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 YqfQ PF14181.1 EFX02889.1 - 8.5 6.3 6.5 14 5.6 4.5 1.3 1 0 0 1 1 1 0 YqfQ-like protein AA_permease PF00324.16 EFX02890.1 - 3e-120 401.7 41.2 3e-120 401.7 28.5 2.4 3 0 0 3 3 3 1 Amino acid permease Voltage_CLC PF00654.15 EFX02890.1 - 6.2e-86 288.6 29.8 6.2e-86 288.6 20.6 4.0 4 2 0 4 4 4 1 Voltage gated chloride channel AA_permease_2 PF13520.1 EFX02890.1 - 3.3e-29 101.6 44.2 3.3e-29 101.6 30.6 3.0 3 1 0 3 3 3 1 Amino acid permease CBS PF00571.23 EFX02890.1 - 6.3e-12 45.0 0.1 3.6e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain ASCH PF04266.9 EFX02890.1 - 0.028 14.7 0.0 0.065 13.6 0.0 1.5 1 0 0 1 1 1 0 ASCH domain Zn_clus PF00172.13 EFX02891.1 - 3.7e-07 29.9 11.5 6.5e-07 29.1 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFX02891.1 - 0.00014 20.6 0.1 0.0002 20.0 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Opy2 PF09463.5 EFX02891.1 - 0.17 12.0 2.9 0.39 10.8 2.0 1.6 1 0 0 1 1 1 0 Opy2 protein SIS PF01380.17 EFX02892.1 - 1.1e-14 54.1 0.1 1.3e-13 50.7 0.0 2.3 2 0 0 2 2 2 1 SIS domain SAE2 PF08573.5 EFX02893.1 - 2.3e-26 92.2 6.5 4.3e-26 91.4 0.2 3.1 3 0 0 3 3 3 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Mnd1 PF03962.10 EFX02893.1 - 5.2 6.6 9.7 1.5 8.4 0.7 2.6 2 0 0 2 2 2 0 Mnd1 family RhoGEF PF00621.15 EFX02894.1 - 1.1e-07 31.9 0.6 3.9e-06 26.8 0.0 2.3 1 1 1 2 2 2 2 RhoGEF domain SUV3_C PF12513.3 EFX02895.1 - 6.3e-17 60.7 0.8 1.3e-16 59.7 0.5 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 EFX02895.1 - 9.9e-09 34.9 0.0 2.3e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TK PF00265.13 EFX02895.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Thymidine kinase Phage-MuB_C PF09077.6 EFX02895.1 - 1.3 8.7 5.1 4.3 7.0 0.2 2.8 3 0 0 3 3 3 0 Mu B transposition protein, C terminal E1-E2_ATPase PF00122.15 EFX02896.1 - 5.6e-60 202.2 6.7 1.8e-59 200.5 4.3 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EFX02896.1 - 3.8e-45 153.6 5.9 3.8e-45 153.6 4.1 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EFX02896.1 - 7.4e-33 114.7 0.0 8e-32 111.3 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX02896.1 - 2.2e-21 75.6 0.0 4.1e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EFX02896.1 - 9.2e-19 66.6 0.0 2.6e-18 65.2 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 EFX02896.1 - 8.3e-16 58.7 0.0 2.7e-15 57.0 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFX02896.1 - 3.1e-07 30.2 0.8 4.3e-06 26.4 0.4 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX02896.1 - 0.02 15.1 0.0 0.078 13.1 0.0 2.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Tyr-DNA_phospho PF06087.7 EFX02897.1 - 8.7e-130 433.2 0.0 1e-129 433.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 EFX02897.1 - 0.016 14.9 0.0 1 9.1 0.0 2.3 2 0 0 2 2 2 0 PLD-like domain LRR_9 PF14580.1 EFX02898.1 - 4.5e-50 169.6 0.0 6.8e-50 169.0 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 EFX02898.1 - 2.4e-13 49.6 15.7 1.7e-06 27.6 0.7 3.3 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 EFX02898.1 - 2.8e-11 42.7 13.0 9.5e-08 31.5 0.6 4.1 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 EFX02898.1 - 0.00023 20.8 4.9 0.39 11.0 0.4 4.8 4 0 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.28 EFX02898.1 - 0.00062 19.4 3.4 11 6.5 0.3 5.1 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.1 EFX02898.1 - 0.0019 18.0 2.0 0.22 11.6 0.3 4.2 5 0 0 5 5 5 1 Leucine Rich repeat DUF4349 PF14257.1 EFX02898.1 - 0.075 12.2 4.2 0.12 11.6 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) MoCF_biosynth PF00994.19 EFX02899.1 - 4.8e-21 74.6 0.0 1.3e-20 73.2 0.0 1.7 1 1 0 1 1 1 1 Probable molybdopterin binding domain Spc97_Spc98 PF04130.8 EFX02902.1 - 1.2e-112 376.9 0.0 1.6e-112 376.6 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Glypican PF01153.14 EFX02903.1 - 0.25 9.9 0.9 0.27 9.7 0.6 1.1 1 0 0 1 1 1 0 Glypican CDC45 PF02724.9 EFX02903.1 - 2.6 5.9 11.1 6.1 4.7 7.1 1.8 2 0 0 2 2 2 0 CDC45-like protein TcdB_toxin_midN PF12256.3 EFX02904.1 - 0.05 13.0 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region Ribosomal_L37e PF01907.14 EFX02905.1 - 1.5e-27 95.1 11.8 2.7e-27 94.2 8.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.2 EFX02905.1 - 0.0078 16.0 1.5 0.012 15.3 1.0 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.14 EFX02905.1 - 0.086 12.5 1.1 0.12 12.0 0.8 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-Mss51 PF13824.1 EFX02905.1 - 0.22 11.3 2.5 0.35 10.7 1.7 1.4 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C4pol PF14260.1 EFX02905.1 - 0.28 11.2 3.7 0.33 10.9 2.1 1.5 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zinc_ribbon_2 PF13240.1 EFX02905.1 - 0.4 10.2 2.6 15 5.1 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GATA PF00320.22 EFX02905.1 - 0.57 9.5 5.1 4.8 6.6 0.1 2.4 1 1 1 2 2 2 0 GATA zinc finger Ribosomal_S14 PF00253.16 EFX02905.1 - 0.64 9.4 11.2 0.43 10.0 1.0 2.6 1 1 2 3 3 3 0 Ribosomal protein S14p/S29e OrfB_Zn_ribbon PF07282.6 EFX02905.1 - 1 9.0 4.3 1.8 8.3 3.0 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-C3HC4 PF00097.20 EFX02905.1 - 3.9 7.2 6.4 6.7 6.4 4.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_L40e PF01020.12 EFX02905.1 - 8.2 6.1 10.3 17 5.1 2.7 2.3 1 1 1 2 2 2 0 Ribosomal L40e family Cofilin_ADF PF00241.15 EFX02907.1 - 2.5e-10 40.2 0.0 3.1e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ABC_tran PF00005.22 EFX02908.1 - 5.1e-53 179.0 0.0 1.9e-29 102.7 0.0 3.8 3 1 0 3 3 3 2 ABC transporter ABC_membrane PF00664.18 EFX02908.1 - 3.9e-32 111.7 23.4 1.1e-20 74.1 8.7 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.14 EFX02908.1 - 3.4e-08 32.9 0.4 0.041 13.1 0.0 4.0 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 EFX02908.1 - 9.5e-08 31.6 0.3 0.011 15.1 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 EFX02908.1 - 3.4e-07 29.6 0.0 0.0065 15.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EFX02908.1 - 4.8e-06 27.0 0.1 0.0011 19.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 EFX02908.1 - 2e-05 24.5 0.9 0.027 14.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_10 PF12846.2 EFX02908.1 - 4.7e-05 22.9 0.1 1.1 8.5 0.0 3.3 3 0 0 3 3 3 1 AAA-like domain T2SE PF00437.15 EFX02908.1 - 7.3e-05 21.7 0.0 0.0084 15.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.1 EFX02908.1 - 0.00013 22.0 4.5 0.33 10.9 0.1 3.5 3 1 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.1 EFX02908.1 - 0.00073 19.6 0.1 5.4 7.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 EFX02908.1 - 0.0033 18.2 0.0 0.45 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EFX02908.1 - 0.0036 16.4 0.1 0.46 9.5 0.0 2.6 2 1 0 2 2 2 1 Zeta toxin AAA_21 PF13304.1 EFX02908.1 - 0.0041 17.1 0.0 15 5.4 0.0 3.5 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.18 EFX02908.1 - 0.0056 16.6 0.0 2.5 8.1 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.7 EFX02908.1 - 0.015 14.9 0.5 2 8.0 0.1 2.4 2 0 0 2 2 2 0 NACHT domain DUF258 PF03193.11 EFX02908.1 - 0.03 13.5 0.0 3.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 EFX02908.1 - 0.035 13.5 0.1 5.7 6.3 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Miro PF08477.8 EFX02908.1 - 0.047 14.1 0.1 9 6.8 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein Sigma54_activat PF00158.21 EFX02908.1 - 0.059 12.8 0.0 12 5.3 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_19 PF13245.1 EFX02908.1 - 0.1 12.3 2.8 5.2 6.9 0.1 3.1 3 0 0 3 3 2 0 Part of AAA domain AAA_18 PF13238.1 EFX02908.1 - 0.1 12.8 1.2 15 5.9 0.1 3.2 3 0 0 3 3 3 0 AAA domain KaiC PF06745.8 EFX02908.1 - 0.11 11.5 0.2 2.3 7.2 0.0 2.3 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.4 EFX02908.1 - 0.14 11.0 0.2 0.95 8.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 EFX02908.1 - 0.21 10.4 0.1 5 5.8 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain DUF1712 PF08217.6 EFX02908.1 - 0.39 8.9 0.1 0.61 8.2 0.1 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1712) NTPase_1 PF03266.10 EFX02908.1 - 0.42 10.3 1.2 19 4.9 0.0 2.9 3 0 0 3 3 3 0 NTPase EXOSC1 PF10447.4 EFX02909.1 - 8.5e-27 92.9 1.6 1.3e-26 92.3 1.1 1.3 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.1 EFX02909.1 - 2.7e-14 52.1 0.1 5.8e-14 51.0 0.1 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region WD40 PF00400.27 EFX02910.1 - 4.2e-21 73.9 3.6 3.5e-06 26.6 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Translin PF01997.11 EFX02911.1 - 3.5e-40 137.7 0.0 4.3e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Translin family NCA2 PF08637.5 EFX02912.1 - 2e-87 292.7 0.0 3.5e-87 291.9 0.0 1.3 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Sec10 PF07393.6 EFX02914.1 - 1.2e-196 655.1 8.0 1.5e-134 449.8 4.7 2.1 1 1 1 2 2 2 2 Exocyst complex component Sec10 BTG PF07742.7 EFX02914.1 - 0.078 12.4 0.3 34 3.9 0.0 3.4 2 1 1 3 3 3 0 BTG family Mito_fiss_reg PF05308.6 EFX02915.1 - 3.6 6.8 8.8 0.68 9.2 0.3 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator OTT_1508_deam PF14441.1 EFX02917.1 - 2.6e-15 56.5 0.0 5.9e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase DUF1601 PF07671.6 EFX02917.1 - 0.16 11.6 1.0 1.8 8.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1601) DUF1770 PF08589.5 EFX02918.1 - 2.8e-18 66.3 0.0 5.7e-18 65.3 0.0 1.5 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF1770) MRC1 PF09444.5 EFX02919.1 - 1.1e-41 142.4 17.0 1.1e-41 142.4 11.8 7.6 5 2 1 6 6 6 1 MRC1-like domain GATA PF00320.22 EFX02920.1 - 1.3e-29 101.2 15.7 8.4e-16 57.0 2.8 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.7 EFX02920.1 - 0.00026 20.2 3.6 0.29 10.5 0.1 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding RRN7 PF11781.3 EFX02920.1 - 0.00059 19.2 5.1 0.0032 16.9 0.2 2.5 2 0 0 2 2 2 1 RNA polymerase I-specific transcription initiation factor Rrn7 OrfB_Zn_ribbon PF07282.6 EFX02920.1 - 0.037 13.6 3.9 0.35 10.5 0.2 2.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DUF2318 PF10080.4 EFX02920.1 - 0.079 12.7 1.0 0.71 9.6 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) Zn-ribbon_8 PF09723.5 EFX02920.1 - 0.1 12.5 1.4 5.9 6.9 0.1 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Auto_anti-p27 PF06677.7 EFX02920.1 - 0.14 11.9 2.2 4.8 7.0 0.1 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-CHY PF05495.7 EFX02920.1 - 0.32 11.1 2.4 4.8 7.4 0.1 2.7 2 1 0 2 2 2 0 CHY zinc finger zf-C2H2_3 PF13878.1 EFX02920.1 - 0.4 10.2 7.6 11 5.7 0.2 4.1 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO Zn_Tnp_IS1595 PF12760.2 EFX02920.1 - 0.41 10.4 5.8 0.77 9.6 0.3 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain eIF-5_eIF-2B PF01873.12 EFX02920.1 - 1 9.0 4.5 4.1 7.0 0.3 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zf-Sec23_Sec24 PF04810.10 EFX02920.1 - 1.9 8.1 9.9 0.043 13.3 0.9 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger HypA PF01155.14 EFX02920.1 - 2.2 7.9 4.9 1.5 8.4 0.3 2.4 2 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family adh_short PF00106.20 EFX02921.1 - 2.2e-32 112.2 0.1 4.1e-32 111.4 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX02921.1 - 3.9e-12 46.1 0.0 6e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 EFX02921.1 - 0.058 13.1 1.7 0.13 12.0 1.2 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase TAP42 PF04177.7 EFX02922.1 - 6e-82 275.3 0.0 8.8e-82 274.7 0.0 1.2 1 0 0 1 1 1 1 TAP42-like family Cwf_Cwc_15 PF04889.7 EFX02922.1 - 0.01 15.5 3.4 0.018 14.7 2.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AAA_12 PF13087.1 EFX02923.1 - 2.2e-26 92.4 0.0 3.7e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFX02923.1 - 3e-21 76.0 0.0 8.8e-21 74.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX02923.1 - 1.5e-09 37.4 0.2 2.5e-08 33.5 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 EFX02923.1 - 9.5e-06 25.3 0.0 0.00069 19.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 EFX02923.1 - 0.00083 19.2 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 EFX02923.1 - 0.001 18.5 0.0 0.0024 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EFX02923.1 - 0.0036 17.4 0.0 0.0088 16.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX02923.1 - 0.0074 16.4 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 EFX02923.1 - 0.0096 15.4 0.1 0.04 13.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Zeta_toxin PF06414.7 EFX02923.1 - 0.015 14.4 0.1 0.061 12.4 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin Parvo_NS1 PF01057.12 EFX02923.1 - 0.036 12.9 0.0 0.072 11.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.13 EFX02923.1 - 0.037 13.5 0.0 1.7 8.1 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 EFX02923.1 - 0.045 12.7 0.7 0.07 12.0 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SMC_N PF02463.14 EFX02923.1 - 0.055 12.6 0.0 0.083 12.1 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFX02923.1 - 0.055 14.2 0.2 0.52 11.1 0.0 2.9 2 1 0 2 2 1 0 AAA domain RecA PF00154.16 EFX02923.1 - 0.058 12.4 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein NB-ARC PF00931.17 EFX02923.1 - 0.14 10.9 0.0 0.31 9.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.17 EFX02923.1 - 0.2 11.8 0.0 0.59 10.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase WD40 PF00400.27 EFX02925.1 - 3.6e-12 45.6 1.2 0.00025 20.7 0.0 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat Nucleoplasmin PF03066.10 EFX02925.1 - 0.12 11.8 7.3 5.1 6.5 0.0 2.9 3 0 0 3 3 3 0 Nucleoplasmin 4HBT PF03061.17 EFX02926.1 - 5.5e-08 32.8 0.0 7.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.1 EFX02926.1 - 4.3e-05 23.9 0.1 5.3e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.12 EFX02926.1 - 0.00018 20.5 1.8 0.00037 19.5 1.3 1.4 1 1 1 2 2 2 1 Acyl-ACP thioesterase Kinesin PF00225.18 EFX02927.1 - 1.8e-112 375.3 0.1 3.8e-112 374.3 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain Pkinase PF00069.20 EFX02928.1 - 5.8e-68 228.8 0.0 1.2e-67 227.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX02928.1 - 2.7e-48 164.2 0.0 4.9e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 EFX02928.1 - 3.8e-28 97.4 0.1 1.1e-27 96.0 0.0 1.9 2 0 0 2 2 2 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 EFX02928.1 - 5.4e-17 61.4 0.3 2.9e-16 59.0 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EFX02928.1 - 2.1e-15 56.6 0.1 4.4e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 EFX02928.1 - 3.4e-12 46.6 0.2 1e-11 45.1 0.0 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.1 EFX02928.1 - 2e-08 33.5 0.0 5.9e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SAM_PNT PF02198.11 EFX02928.1 - 0.0053 16.4 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Kdo PF06293.9 EFX02928.1 - 0.071 12.1 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2771 PF10969.3 EFX02929.1 - 0.12 11.6 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2771) FAD_binding_3 PF01494.14 EFX02930.1 - 5.9e-17 61.7 1.9 2.1e-11 43.4 1.0 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 EFX02930.1 - 0.00049 20.0 0.4 0.058 13.4 0.0 2.9 2 1 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DUF4094 PF13334.1 EFX02931.1 - 0.098 13.0 0.7 1.6 9.1 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) Latarcin PF10279.4 EFX02931.1 - 0.12 12.5 3.2 2.9 8.1 0.1 2.4 1 1 1 2 2 2 0 Latarcin precursor TFIIA_gamma_N PF02268.11 EFX02934.1 - 4.8e-26 90.0 0.3 6.7e-26 89.6 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.9 EFX02934.1 - 5.7e-25 86.8 0.1 7.7e-25 86.4 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit RNase_E_G PF10150.4 EFX02934.1 - 0.098 11.8 0.0 0.11 11.6 0.0 1.0 1 0 0 1 1 1 0 Ribonuclease E/G family Methyltransf_11 PF08241.7 EFX02935.1 - 9e-10 38.9 0.0 1.9e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX02935.1 - 4.3e-09 36.2 0.0 6.6e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02935.1 - 0.0022 18.4 0.0 0.0087 16.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02935.1 - 0.004 16.7 0.0 0.0085 15.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFX02935.1 - 0.035 13.7 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_25 PF13649.1 EFX02935.1 - 0.042 14.2 0.0 0.12 12.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 EFX02935.1 - 0.072 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.7 EFX02935.1 - 0.15 11.3 0.1 0.28 10.4 0.1 1.5 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_18 PF12847.2 EFX02935.1 - 0.15 12.6 0.0 0.66 10.5 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_L32e PF01655.13 EFX02936.1 - 5.4e-49 164.8 1.9 7e-49 164.4 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 cNMP_binding PF00027.24 EFX02937.1 - 1.4e-39 133.7 0.0 4.2e-19 68.1 0.0 4.6 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.17 EFX02937.1 - 3.7e-15 56.3 6.3 3.9e-14 53.0 4.3 2.5 1 1 0 1 1 1 1 Patatin-like phospholipase POP1 PF06978.6 EFX02938.1 - 1.5e-28 99.7 12.8 5.2e-16 58.8 3.8 3.0 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 EFX02938.1 - 9.3e-23 79.8 0.1 9.3e-23 79.8 0.1 2.3 3 0 0 3 3 3 1 POPLD (NUC188) domain GCV_T_C PF08669.6 EFX02938.1 - 0.027 14.4 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain DUF4048 PF13257.1 EFX02939.1 - 6.6e-09 35.7 26.6 1.4e-08 34.6 12.2 4.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4048) AAA_2 PF07724.9 EFX02940.1 - 5.5e-12 45.9 0.0 1.3e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 EFX02940.1 - 3.7e-10 39.6 0.0 6.6e-09 35.6 0.0 2.6 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA PF00004.24 EFX02940.1 - 5.6e-06 26.5 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.6 EFX02940.1 - 5.5e-05 23.0 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 Torsin ClpB_D2-small PF10431.4 EFX02940.1 - 0.00014 21.6 0.1 0.00035 20.4 0.1 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.1 EFX02940.1 - 0.0022 17.9 0.6 0.071 13.0 0.0 3.0 1 1 1 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.16 EFX02940.1 - 0.0028 16.8 0.1 2.2 7.3 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 EFX02940.1 - 0.0066 17.2 0.1 0.041 14.6 0.0 2.3 3 0 0 3 3 2 1 AAA domain Sigma54_activat PF00158.21 EFX02940.1 - 0.017 14.5 0.0 0.037 13.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 EFX02940.1 - 0.021 13.9 0.0 0.066 12.2 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_6 PF12774.2 EFX02940.1 - 0.031 13.8 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region D1 AAA_22 PF13401.1 EFX02940.1 - 0.048 13.8 0.1 0.48 10.5 0.1 2.6 1 1 0 1 1 1 0 AAA domain Ank_4 PF13637.1 EFX02940.1 - 0.052 14.0 0.0 0.26 11.8 0.0 2.2 2 0 0 2 2 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.2 EFX02940.1 - 0.074 13.4 0.0 0.53 10.6 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) AAA_33 PF13671.1 EFX02940.1 - 0.088 12.6 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 EFX02940.1 - 0.09 12.8 0.0 0.26 11.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Scytalone_dh PF02982.9 EFX02941.1 - 1.1e-56 190.8 1.1 1.2e-56 190.6 0.8 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.1 EFX02941.1 - 1.7e-10 40.9 2.1 2.1e-10 40.5 1.4 1.2 1 0 0 1 1 1 1 SnoaL-like domain GATA PF00320.22 EFX02942.1 - 1.7e-16 59.2 1.9 3.6e-16 58.2 1.3 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 EFX02942.1 - 1.7e-12 46.7 0.6 3e-12 45.9 0.4 1.4 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) p450 PF00067.17 EFX02943.1 - 1.4e-28 99.6 0.0 9.6e-17 60.6 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 Methyltransf_23 PF13489.1 EFX02944.1 - 1.1e-14 54.4 0.0 3.9e-14 52.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02944.1 - 6.4e-06 26.7 0.3 0.0006 20.3 0.1 2.9 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 EFX02944.1 - 0.00023 21.2 0.4 0.00049 20.1 0.1 1.5 1 1 1 2 2 2 1 FtsJ-like methyltransferase Methyltransf_11 PF08241.7 EFX02944.1 - 0.001 19.5 0.0 0.0041 17.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02944.1 - 0.0016 18.8 0.1 0.031 14.7 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02944.1 - 0.0018 17.9 0.0 0.071 12.6 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX02944.1 - 0.14 12.5 0.0 0.95 9.8 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain Zip PF02535.17 EFX02945.1 - 1e-54 185.6 10.0 9e-45 153.0 4.1 2.2 1 1 1 2 2 2 2 ZIP Zinc transporter Phage_holin_5 PF06946.6 EFX02945.1 - 1.2 9.3 6.9 3.1 8.0 2.2 3.0 3 0 0 3 3 3 0 Phage holin FtsX PF02687.16 EFX02945.1 - 4.3 7.1 16.0 0.38 10.5 2.4 3.8 4 1 0 4 4 4 0 FtsX-like permease family AJAP1_PANP_C PF15298.1 EFX02946.1 - 0.066 13.0 4.2 0.13 12.1 2.9 1.5 1 0 0 1 1 1 0 AJAP1/PANP C-terminus VSP PF03302.8 EFX02946.1 - 0.66 8.5 9.4 0.021 13.5 2.3 1.5 2 0 0 2 2 2 0 Giardia variant-specific surface protein CBFD_NFYB_HMF PF00808.18 EFX02947.1 - 1.1e-06 28.5 0.0 0.013 15.5 0.0 2.5 2 0 0 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone FGGY_C PF02782.11 EFX02948.1 - 9.1e-70 234.3 1.8 1.9e-69 233.2 1.3 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFX02948.1 - 3.5e-58 196.7 0.0 4.7e-58 196.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Homeobox_KN PF05920.6 EFX02949.1 - 2.4e-20 71.9 0.4 4.5e-20 71.0 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 EFX02949.1 - 1.7e-08 33.9 1.3 3e-08 33.1 0.9 1.4 1 0 0 1 1 1 1 Homeobox domain Nup88 PF10168.4 EFX02950.1 - 0.00032 18.6 1.1 0.26 9.0 0.0 2.5 3 0 0 3 3 3 2 Nuclear pore component Hemerythrin PF01814.18 EFX02950.1 - 0.031 14.4 0.7 0.066 13.3 0.5 1.5 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain DUF1319 PF07028.6 EFX02950.1 - 0.09 12.9 0.3 0.21 11.7 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Nup54 PF13874.1 EFX02950.1 - 0.091 12.4 6.6 0.16 11.6 1.8 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 GAS PF13851.1 EFX02950.1 - 0.81 8.8 3.1 0.38 9.9 0.3 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding MFS_1 PF07690.11 EFX02951.1 - 2.1e-38 131.9 48.2 2.9e-38 131.4 33.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX02951.1 - 3.9e-11 41.8 21.4 6.9e-11 41.0 14.8 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PALP PF00291.20 EFX02952.1 - 1.5e-54 185.2 0.1 1.9e-54 184.9 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 EFX02952.1 - 5e-09 35.8 0.1 2.8e-07 30.2 0.0 2.6 2 0 0 2 2 2 1 CBS domain PRMT5 PF05185.11 EFX02952.1 - 0.14 11.0 0.1 0.25 10.2 0.1 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase NAD_Gly3P_dh_N PF01210.18 EFX02952.1 - 0.3 10.8 2.2 14 5.3 0.1 3.0 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus p450 PF00067.17 EFX02953.1 - 2.8e-52 177.7 0.0 6.4e-52 176.6 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Solute_trans_a PF03619.11 EFX02955.1 - 5.3e-82 275.2 0.5 4.6e-80 268.8 0.0 2.0 1 1 1 2 2 2 2 Organic solute transporter Ostalpha Dpy-30 PF05186.8 EFX02956.1 - 0.00031 20.1 0.0 0.00046 19.6 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif PseudoU_synth_2 PF00849.17 EFX02957.1 - 3.1e-33 114.9 0.0 5.4e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ub-Mut7C PF14451.1 EFX02957.1 - 0.068 12.6 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Mut7-C ubiquitin adh_short PF00106.20 EFX02958.1 - 5.4e-33 114.2 1.6 7.7e-33 113.7 1.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX02958.1 - 3.3e-27 95.8 0.0 4.3e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX02958.1 - 3.3e-16 59.4 0.4 4.8e-16 58.9 0.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX02958.1 - 0.00037 20.0 0.0 0.00061 19.2 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ctr PF04145.10 EFX02959.1 - 3.9e-38 130.7 2.9 4.6e-38 130.4 2.0 1.0 1 0 0 1 1 1 1 Ctr copper transporter family DUF1049 PF06305.6 EFX02959.1 - 0.35 10.3 2.3 14 5.2 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Cytochrom_B_N PF00033.14 EFX02959.1 - 1.8 7.8 8.5 19 4.5 5.9 2.0 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Arylesterase PF01731.15 EFX02960.1 - 1.4e-05 25.0 0.0 2.9e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Arylesterase MMR_HSR1_C PF08438.5 EFX02961.1 - 8.9e-30 103.1 0.0 1.6e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 EFX02961.1 - 1.2e-13 51.0 0.0 3.6e-13 49.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX02961.1 - 1.3e-05 24.5 0.0 0.00056 19.2 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EFX02961.1 - 0.0028 17.4 1.5 0.024 14.4 0.3 2.7 3 0 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.22 EFX02961.1 - 0.017 14.5 0.0 1.2 8.5 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Miro PF08477.8 EFX02961.1 - 0.083 13.3 0.1 0.38 11.2 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein Arrestin_C PF02752.17 EFX02962.1 - 3.3e-18 66.0 0.0 9.1e-18 64.6 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EFX02962.1 - 3.2e-12 46.5 0.0 5.9e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 EFX02962.1 - 0.0032 17.0 0.0 0.0091 15.5 0.0 1.7 2 0 0 2 2 2 1 Arrestin_N terminal like AAA_25 PF13481.1 EFX02963.1 - 0.0019 17.6 0.0 0.0024 17.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain zf-AD PF07776.10 EFX02963.1 - 0.026 14.5 1.3 0.026 14.5 0.9 2.2 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) ZZ PF00569.12 EFX02963.1 - 3.6 7.2 7.8 19 4.9 0.3 3.0 2 1 0 2 2 2 0 Zinc finger, ZZ type Fe-ADH PF00465.14 EFX02964.1 - 0.071 11.7 0.2 0.14 10.8 0.1 1.4 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase CMAS PF02353.15 EFX02966.1 - 1.4e-61 207.9 0.0 1.8e-61 207.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 EFX02966.1 - 1.1e-12 47.9 0.0 2.1e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX02966.1 - 6.2e-08 33.0 0.0 1.1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX02966.1 - 0.00024 20.7 0.0 0.00042 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX02966.1 - 0.00079 19.8 0.0 0.0022 18.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX02966.1 - 0.00085 19.6 0.0 0.0022 18.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX02966.1 - 0.0012 19.3 0.0 0.0041 17.6 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX02966.1 - 0.0052 16.8 0.0 0.019 15.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFX02966.1 - 0.021 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.8 EFX02966.1 - 0.07 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.9 EFX02966.1 - 0.076 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain WD40 PF00400.27 EFX02967.1 - 3.5e-52 172.5 17.3 7.9e-11 41.4 0.2 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EFX02967.1 - 2.6e-12 46.2 0.9 2.6e-12 46.2 0.6 2.3 3 0 0 3 3 3 1 F-box-like Nup160 PF11715.3 EFX02967.1 - 5.9e-10 37.9 11.7 0.016 13.3 0.1 5.2 1 1 3 5 5 5 5 Nucleoporin Nup120/160 F-box PF00646.28 EFX02967.1 - 4.5e-06 26.1 2.4 1e-05 25.0 1.7 1.7 1 0 0 1 1 1 1 F-box domain PQQ_3 PF13570.1 EFX02967.1 - 0.35 11.1 4.1 39 4.6 0.0 4.7 4 1 1 5 5 5 0 PQQ-like domain DUF1512 PF07431.7 EFX02968.1 - 0.088 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) GAS PF13851.1 EFX02969.1 - 0.008 15.3 1.8 0.008 15.3 1.3 3.5 2 2 1 3 3 3 1 Growth-arrest specific micro-tubule binding IncA PF04156.9 EFX02969.1 - 0.011 15.2 27.5 0.036 13.6 3.2 2.4 2 0 0 2 2 2 0 IncA protein DUF1875 PF08961.5 EFX02969.1 - 0.022 14.0 8.1 0.026 13.8 5.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1875) CENP-F_leu_zip PF10473.4 EFX02969.1 - 0.043 13.6 26.3 0.28 11.0 5.5 3.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TLE_N PF03920.10 EFX02969.1 - 0.046 13.5 9.6 1.6 8.5 0.5 3.3 2 1 1 3 3 3 0 Groucho/TLE N-terminal Q-rich domain ZYG-11_interact PF05884.7 EFX02969.1 - 0.054 12.5 0.4 0.085 11.9 0.3 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 ATG16 PF08614.6 EFX02969.1 - 0.16 11.7 26.2 0.69 9.6 8.7 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MT PF12777.2 EFX02969.1 - 0.23 10.1 6.5 0.51 9.0 0.3 2.2 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor ERM PF00769.14 EFX02969.1 - 0.43 10.0 26.4 1.7 8.1 7.4 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Prominin PF05478.6 EFX02969.1 - 0.59 7.6 10.9 1.3 6.4 0.5 2.1 2 0 0 2 2 2 0 Prominin DUF904 PF06005.7 EFX02969.1 - 0.66 10.3 21.7 0.27 11.5 2.9 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF904) Macoilin PF09726.4 EFX02969.1 - 0.78 7.9 18.7 0.066 11.4 2.9 2.0 2 0 0 2 2 2 0 Transmembrane protein Reo_sigmaC PF04582.7 EFX02969.1 - 2.4 7.2 9.4 3 6.9 1.3 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TMF_DNA_bd PF12329.3 EFX02969.1 - 4.9 7.0 30.5 2.2 8.1 2.9 4.4 2 2 2 5 5 5 0 TATA element modulatory factor 1 DNA binding PRP1_N PF06424.7 EFX02969.1 - 6.2 7.1 10.2 0.14 12.4 0.6 2.4 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal AAA_13 PF13166.1 EFX02969.1 - 6.6 5.0 17.9 2.1 6.6 5.7 2.2 1 1 0 2 2 2 0 AAA domain YscO PF07321.7 EFX02969.1 - 10 5.9 29.9 0.04 13.7 8.4 3.1 2 1 1 3 3 3 0 Type III secretion protein YscO Actin PF00022.14 EFX02970.1 - 7.8e-55 185.8 0.0 3.4e-53 180.4 0.0 2.1 1 1 0 1 1 1 1 Actin MFS_1 PF07690.11 EFX02971.1 - 8.2e-32 110.2 43.3 1.3e-31 109.6 30.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily CPSase_sm_chain PF00988.17 EFX02972.1 - 3.9e-47 159.0 0.0 6.7e-47 158.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 EFX02972.1 - 5.1e-46 156.5 0.0 7e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EFX02972.1 - 8.2e-07 28.6 0.1 8.5e-05 22.0 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 Abhydrolase_6 PF12697.2 EFX02973.1 - 1.9e-23 83.5 9.0 1.9e-23 83.5 6.2 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX02973.1 - 8.4e-18 64.7 0.1 5.6e-17 62.0 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX02973.1 - 1.8e-11 43.9 0.1 2.1e-10 40.5 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.6 EFX02973.1 - 7.4e-05 21.9 0.0 0.00013 21.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.15 EFX02973.1 - 0.00016 21.1 0.0 0.00053 19.5 0.0 1.9 2 0 0 2 2 2 1 Putative esterase Thioesterase PF00975.15 EFX02973.1 - 0.0048 17.1 0.5 0.02 15.1 0.3 2.0 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.11 EFX02973.1 - 0.0097 15.3 0.0 2.5 7.5 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 EFX02973.1 - 0.01 15.6 0.0 0.029 14.2 0.0 1.7 1 0 0 1 1 1 0 Putative lysophospholipase Abhydrolase_3 PF07859.8 EFX02973.1 - 0.027 14.0 1.8 0.21 11.1 0.0 2.6 2 1 1 3 3 3 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 EFX02973.1 - 0.037 13.6 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Chlorophyllase2 PF12740.2 EFX02973.1 - 0.13 11.0 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme MR_MLE_C PF13378.1 EFX02974.1 - 4.6e-20 71.6 0.0 1.9e-19 69.6 0.0 1.9 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE PF01188.16 EFX02974.1 - 8.2e-12 45.4 0.0 2.1e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 EFX02974.1 - 1.1e-10 41.5 0.0 1.7e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain SseB PF07179.7 EFX02974.1 - 0.1 12.4 0.0 11 5.8 0.0 2.3 2 0 0 2 2 2 0 SseB protein N-terminal domain adh_short PF00106.20 EFX02975.1 - 1.5e-58 197.4 13.3 4.2e-29 101.6 3.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EFX02975.1 - 5.9e-29 101.0 7.4 3.3e-15 56.1 1.1 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.14 EFX02975.1 - 1.4e-28 98.7 0.0 2.8e-28 97.7 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain Epimerase PF01370.16 EFX02975.1 - 1.3e-05 24.7 3.9 0.0095 15.3 0.2 3.1 2 2 0 2 2 2 2 NAD dependent epimerase/dehydratase family DUF3328 PF11807.3 EFX02976.1 - 6.6e-23 81.5 2.4 1.8e-22 80.0 1.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Hexapep PF00132.19 EFX02978.1 - 0.16 11.5 21.9 8.1 6.1 0.0 8.6 3 1 5 8 8 8 0 Bacterial transferase hexapeptide (six repeats) UQ_con PF00179.21 EFX02979.1 - 1.5e-23 82.8 0.1 2.3e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX02979.1 - 1.7e-06 27.8 0.0 2.4e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFX02979.1 - 0.0057 16.5 0.0 0.0071 16.2 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 EFX02979.1 - 0.02 14.5 0.1 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 UEV domain adh_short PF00106.20 EFX02980.1 - 7.8e-14 51.9 0.0 1.1e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX02980.1 - 9.6e-07 28.6 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFX02980.1 - 0.043 13.8 0.0 0.095 12.7 0.0 1.6 1 0 0 1 1 1 0 NADH(P)-binding SMC_hinge PF06470.8 EFX02980.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain Pyr_redox_2 PF07992.9 EFX02981.1 - 8.7e-28 97.5 0.0 1.8e-27 96.5 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.21 EFX02981.1 - 3.9e-14 52.0 0.0 1.3e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.22 EFX02981.1 - 2.6e-11 43.7 3.1 3.3e-10 40.2 0.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX02981.1 - 8.3e-08 32.5 0.5 0.029 14.4 0.0 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.1 EFX02981.1 - 1.3e-05 25.3 1.2 3.7e-05 23.9 0.0 2.4 3 0 0 3 3 2 1 Reductase C-terminal Rieske_2 PF13806.1 EFX02981.1 - 1.7e-05 24.4 0.0 0.00019 21.0 0.0 2.4 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain NAD_binding_9 PF13454.1 EFX02981.1 - 0.00073 19.3 5.8 1 9.0 0.1 3.3 3 0 0 3 3 3 2 FAD-NAD(P)-binding Malic_M PF03949.10 EFX02981.1 - 0.0017 17.9 0.0 0.0044 16.6 0.0 1.6 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain K_oxygenase PF13434.1 EFX02981.1 - 0.0021 17.0 0.1 1.5 7.6 0.0 2.5 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DUF1188 PF06690.6 EFX02981.1 - 0.038 13.1 0.1 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) NAD_binding_7 PF13241.1 EFX02981.1 - 0.077 13.2 1.5 1.4 9.1 0.1 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding GTP_EFTU PF00009.22 EFX02982.1 - 6.8e-62 208.2 0.2 1.3e-61 207.3 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EFX02982.1 - 5.9e-35 119.4 0.0 1.5e-34 118.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 EFX02982.1 - 1.1e-21 76.4 0.0 2.6e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFX02982.1 - 9e-12 44.9 2.3 1.5e-11 44.2 0.1 2.7 2 0 0 2 2 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EFX02982.1 - 2.2e-11 43.4 0.0 6e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II RRM_6 PF14259.1 EFX02982.1 - 7.9e-08 32.1 0.2 2.7e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX02982.1 - 3.8e-07 29.8 0.1 8.2e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX02982.1 - 9.4e-06 25.1 0.3 5.6e-05 22.6 0.1 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MMR_HSR1 PF01926.18 EFX02982.1 - 0.00012 21.9 0.2 0.00025 20.9 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Nup35_RRM_2 PF14605.1 EFX02982.1 - 0.00084 19.0 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Atg14 PF10186.4 EFX02982.1 - 0.0034 16.3 1.5 0.006 15.5 1.0 1.3 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 zf-CCCH PF00642.19 EFX02982.1 - 0.013 15.1 6.4 0.022 14.4 4.5 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1330 PF07045.6 EFX02982.1 - 0.073 12.9 0.1 0.92 9.4 0.1 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1330) PduV-EutP PF10662.4 EFX02982.1 - 0.2 11.1 0.2 0.52 9.8 0.1 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF4523 PF15023.1 EFX02982.1 - 0.3 10.5 0.0 0.63 9.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) RRM_3 PF08777.6 EFX02982.1 - 0.49 10.2 5.4 0.97 9.3 0.0 3.0 3 0 0 3 3 2 0 RNA binding motif V_ATPase_I PF01496.14 EFX02982.1 - 7 4.3 3.4 11 3.7 2.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HTH_AsnC-type PF13404.1 EFX02983.1 - 0.03 13.8 0.1 0.087 12.3 0.1 1.8 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 EFX02983.1 - 0.12 11.7 0.0 0.48 9.8 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Arrestin_N PF00339.24 EFX02984.1 - 1.9e-12 47.2 0.0 6.5e-07 29.2 0.0 3.3 3 1 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Cwf_Cwc_15 PF04889.7 EFX02984.1 - 0.0028 17.4 1.3 0.0028 17.4 0.9 1.9 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein DUF2112 PF09885.4 EFX02984.1 - 0.028 14.0 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2112) Bul1_C PF04426.7 EFX02984.1 - 0.13 11.4 0.4 0.35 10.0 0.0 1.9 2 0 0 2 2 2 0 Bul1 C terminus JAB PF01398.16 EFX02985.1 - 2.9e-26 91.4 0.0 4.2e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 EFX02985.1 - 5.6e-06 25.8 0.0 1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain FAD_binding_3 PF01494.14 EFX02986.1 - 4.3e-08 32.5 0.2 0.001 18.1 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Metallophos PF00149.23 EFX02987.1 - 1.4e-36 125.7 0.2 2.4e-29 102.1 0.1 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase WD40 PF00400.27 EFX02988.1 - 1.2e-19 69.3 0.0 2.2e-05 24.1 0.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat DUF2767 PF10965.3 EFX02988.1 - 0.06 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2767) Fungal_trans PF04082.13 EFX02989.1 - 2.4e-22 79.0 0.0 4.5e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02989.1 - 2.1e-07 30.7 10.3 3.8e-07 29.9 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_trans_1_2 PF13524.1 EFX02989.1 - 0.65 10.3 4.8 5.5 7.3 0.8 2.6 2 0 0 2 2 2 0 Glycosyl transferases group 1 TFIIA PF03153.8 EFX02989.1 - 3.5 7.4 6.7 0.97 9.2 1.8 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit End3 PF12761.2 EFX02990.1 - 1.2e-69 233.9 0.3 2.1e-69 233.0 0.2 1.4 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.2 EFX02990.1 - 4.1e-47 158.2 0.0 1.4e-46 156.5 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 EFX02990.1 - 1.8e-06 26.8 0.2 3.9e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 EFX02990.1 - 4.9e-05 22.8 0.1 0.00012 21.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 EFX02990.1 - 0.0001 22.3 0.0 0.00037 20.5 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EFX02990.1 - 0.0027 17.4 0.3 0.008 15.9 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 EFX02990.1 - 0.015 14.6 0.2 0.034 13.4 0.1 1.6 1 0 0 1 1 1 0 EF hand API5 PF05918.6 EFX02990.1 - 0.078 11.4 5.5 0.13 10.7 3.8 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Fungal_trans_2 PF11951.3 EFX02991.1 - 1.9e-15 56.4 5.0 6.6e-09 34.8 0.1 2.8 1 1 0 2 2 2 2 Fungal specific transcription factor domain Lant_dehyd_N PF04737.8 EFX02991.1 - 0.083 12.9 0.4 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Lantibiotic dehydratase, N terminus AA_permease PF00324.16 EFX02992.1 - 3.8e-110 368.4 43.7 4.8e-110 368.1 30.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX02992.1 - 3.9e-24 84.9 48.2 4.8e-24 84.6 33.4 1.0 1 0 0 1 1 1 1 Amino acid permease Fungal_trans PF04082.13 EFX02993.1 - 2.6e-38 131.3 0.0 4.2e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX02993.1 - 1.3e-08 34.5 6.7 3.1e-08 33.3 4.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran PF00005.22 EFX02994.1 - 3e-20 72.9 0.0 2.4e-19 69.9 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.18 EFX02994.1 - 1.9e-14 53.7 2.1 2.9e-14 53.1 1.1 1.6 1 1 0 1 1 1 1 ABC transporter transmembrane region SbcCD_C PF13558.1 EFX02994.1 - 7.8e-05 22.5 0.1 0.031 14.1 0.0 2.6 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 EFX02994.1 - 0.00069 18.9 0.0 0.015 14.5 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX02994.1 - 0.021 14.8 0.4 0.097 12.6 0.3 1.9 1 1 0 1 1 1 0 AAA domain Fork_head PF00250.13 EFX02995.1 - 1.8e-33 114.4 0.1 3.8e-33 113.3 0.0 1.5 1 0 0 1 1 1 1 Fork head domain Abhydro_lipase PF04083.11 EFX02996.1 - 0.00019 20.6 0.0 0.00076 18.7 0.0 2.0 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_5 PF12695.2 EFX02996.1 - 0.0063 16.2 0.0 0.02 14.6 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Pep3_Vps18 PF05131.9 EFX02997.1 - 1.3e-45 154.4 0.0 3.7e-45 152.9 0.0 1.9 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 EFX02997.1 - 9.8e-08 31.7 5.8 1.9e-06 27.5 0.1 3.9 4 1 0 4 4 4 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 EFX02997.1 - 4.8e-05 23.1 0.4 0.00012 21.7 0.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EFX02997.1 - 0.00047 19.8 0.4 0.00047 19.8 0.3 1.7 2 0 0 2 2 2 1 zinc-RING finger domain DNA_pol3_theta PF06440.6 EFX02997.1 - 0.0086 15.6 0.1 0.04 13.5 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase III, theta subunit DUF2175 PF09943.4 EFX02997.1 - 0.019 15.0 0.1 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) zf-C3HC4_2 PF13923.1 EFX02997.1 - 0.045 13.7 0.5 0.11 12.5 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.4 EFX02997.1 - 0.057 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4 PF00097.20 EFX02997.1 - 0.44 10.2 3.3 0.14 11.8 0.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Bul1_N PF04425.7 EFX02999.1 - 2.8e-05 22.8 0.1 0.31 9.5 0.0 3.1 2 1 1 3 3 3 3 Bul1 N terminus Bul1_C PF04426.7 EFX02999.1 - 0.0025 17.0 0.0 0.0054 15.9 0.0 1.6 1 0 0 1 1 1 1 Bul1 C terminus Arrestin_N PF00339.24 EFX02999.1 - 0.0075 16.1 0.0 0.023 14.4 0.0 1.8 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Anillin PF08174.6 EFX02999.1 - 0.23 11.5 2.6 1.2 9.1 0.7 2.5 3 0 0 3 3 3 0 Cell division protein anillin SSF PF00474.12 EFX03000.1 - 2.7e-06 26.2 30.0 1e-05 24.3 20.6 2.1 1 1 0 1 1 1 1 Sodium:solute symporter family BcrAD_BadFG PF01869.15 EFX03001.1 - 3.9e-21 75.5 1.0 5.3e-21 75.1 0.7 1.2 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Ras PF00071.17 EFX03002.1 - 3.8e-59 198.6 0.3 4.5e-59 198.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX03002.1 - 5.3e-19 68.8 0.0 8.5e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX03002.1 - 2.1e-08 33.6 0.0 2.3e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFX03002.1 - 3.1e-07 30.0 0.1 1.4e-06 27.8 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EFX03002.1 - 0.0021 18.0 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX03002.1 - 0.0039 16.4 0.0 0.0075 15.5 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.7 EFX03002.1 - 0.018 14.1 0.1 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF258 PF03193.11 EFX03002.1 - 0.044 12.9 0.2 0.089 11.9 0.1 1.6 2 1 0 2 2 2 0 Protein of unknown function, DUF258 ATP_bind_1 PF03029.12 EFX03002.1 - 0.1 12.1 1.5 1.4 8.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Ras PF00071.17 EFX03003.1 - 3.5e-64 215.0 0.0 5.1e-64 214.5 0.0 1.2 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EFX03003.1 - 1.4e-19 70.7 0.0 2.2e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX03003.1 - 5.1e-13 48.6 0.0 6.6e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFX03003.1 - 2.1e-06 27.3 0.1 3.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFX03003.1 - 4.7e-06 25.9 0.0 5.2e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFX03003.1 - 0.0029 17.5 0.0 0.0089 15.9 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EFX03003.1 - 0.025 13.8 0.0 0.13 11.4 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B SRPRB PF09439.5 EFX03003.1 - 0.036 13.3 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.15 EFX03003.1 - 0.061 12.0 0.7 5.3 5.6 0.1 2.7 1 1 1 2 2 2 0 G-protein alpha subunit AAA_29 PF13555.1 EFX03003.1 - 0.092 12.2 0.0 0.28 10.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 EFX03003.1 - 0.099 11.8 0.0 0.24 10.5 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX03003.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.9 1 1 1 2 2 2 0 AAA domain RRM_1 PF00076.17 EFX03004.1 - 6.6e-16 57.6 0.0 9.8e-16 57.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03004.1 - 3.2e-12 46.2 0.0 5.3e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03004.1 - 8.7e-09 35.1 0.1 1.6e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MKT1_C PF12246.3 EFX03005.1 - 1.7e-50 171.3 0.0 2.2e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 EFX03005.1 - 2.9e-25 88.4 0.4 1.1e-24 86.4 0.1 2.1 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 EFX03005.1 - 7.2e-05 22.7 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EFX03005.1 - 0.0041 17.3 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain Myb_DNA-binding PF00249.26 EFX03007.1 - 0.0003 20.7 0.3 0.039 14.0 0.0 3.9 4 0 0 4 4 4 1 Myb-like DNA-binding domain CDC45 PF02724.9 EFX03007.1 - 0.1 10.6 25.6 0.52 8.2 8.8 2.2 2 0 0 2 2 2 0 CDC45-like protein BUD22 PF09073.5 EFX03007.1 - 0.23 10.4 34.1 0.037 13.0 5.6 2.2 2 0 0 2 2 2 0 BUD22 SAPS PF04499.10 EFX03007.1 - 2.5 6.6 8.5 8.4 4.9 0.1 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Daxx PF03344.10 EFX03007.1 - 3.1 6.1 40.1 0.84 8.0 8.8 2.2 2 0 0 2 2 2 0 Daxx Family NAD_binding_6 PF08030.7 EFX03008.1 - 3.9e-22 78.8 0.0 1.5e-14 54.2 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EFX03008.1 - 7.3e-22 77.7 7.9 7.3e-22 77.7 5.5 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EFX03008.1 - 5.3e-12 45.5 0.0 6.2e-08 32.4 0.0 2.5 1 1 1 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.16 EFX03008.1 - 0.072 13.6 0.0 0.24 11.9 0.0 1.9 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Thiolase_N PF00108.18 EFX03009.1 - 2.2e-93 312.0 1.1 3.9e-93 311.2 0.8 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFX03009.1 - 3.9e-38 129.6 0.7 3.9e-38 129.6 0.5 2.2 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFX03009.1 - 7.2e-05 22.3 1.7 7.2e-05 22.3 1.2 2.8 3 1 1 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain Chal_sti_synt_N PF00195.14 EFX03009.1 - 0.0053 16.0 0.9 0.027 13.7 0.0 2.1 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.5 EFX03009.1 - 0.63 9.7 6.4 2.3 7.9 0.0 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YjeF_N PF03853.10 EFX03011.1 - 6.7e-35 120.1 0.0 1.1e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 EFX03011.1 - 2.2e-08 34.5 1.6 3.5e-08 33.9 0.0 2.2 3 0 0 3 3 3 1 FDF domain UDPG_MGDP_dh_N PF03721.9 EFX03012.1 - 1.1e-46 158.5 0.0 3.1e-45 153.8 0.0 2.7 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 EFX03012.1 - 7.4e-27 93.4 0.0 1.6e-26 92.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 EFX03012.1 - 1.7e-21 76.3 0.2 6.7e-16 58.3 0.0 3.4 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.10 EFX03012.1 - 0.00055 19.8 0.6 0.032 14.0 0.1 3.5 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 EFX03012.1 - 0.007 16.1 0.5 0.027 14.1 0.2 2.1 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PIG-F PF06699.6 EFX03013.1 - 1.7e-47 161.8 4.3 2.4e-47 161.3 3.0 1.2 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F FA_desaturase PF00487.19 EFX03013.1 - 0.059 12.8 0.2 0.059 12.8 0.1 2.2 1 1 1 2 2 2 0 Fatty acid desaturase Gly-zipper_OmpA PF13436.1 EFX03013.1 - 0.085 12.5 11.3 0.31 10.7 0.2 3.9 3 1 1 4 4 4 0 Glycine-zipper containing OmpA-like membrane domain Peptidase_S9 PF00326.16 EFX03014.1 - 3.8e-35 121.0 0.3 8e-35 119.9 0.2 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family NuA4 PF09340.5 EFX03014.1 - 4e-25 87.2 0.5 8.1e-25 86.2 0.4 1.5 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Abhydrolase_5 PF12695.2 EFX03014.1 - 1.1e-06 28.4 0.1 2.4e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family PD40 PF07676.7 EFX03014.1 - 0.0052 16.4 0.2 0.03 14.0 0.0 2.3 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat AXE1 PF05448.7 EFX03014.1 - 0.032 12.7 0.5 0.51 8.7 0.3 2.2 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) LRR_8 PF13855.1 EFX03015.1 - 1.3e-13 50.4 0.0 3.6e-06 26.6 0.1 3.2 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 EFX03015.1 - 1.7e-11 43.4 0.0 0.025 14.1 0.0 4.4 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.12 EFX03015.1 - 2.3e-09 36.6 0.0 1.6e-07 30.6 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase LRR_1 PF00560.28 EFX03015.1 - 1.8e-08 33.2 0.0 0.26 11.4 0.0 5.6 6 0 0 6 6 5 2 Leucine Rich Repeat Pkinase PF00069.20 EFX03015.1 - 1.8e-07 30.6 0.2 4.7e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 EFX03015.1 - 2e-05 23.7 0.0 3.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_7 PF13504.1 EFX03015.1 - 0.00047 19.9 5.9 17 6.1 0.0 5.8 6 0 0 6 6 5 0 Leucine rich repeat APH PF01636.18 EFX03015.1 - 0.023 14.4 3.5 0.38 10.4 0.0 3.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family GP46 PF07409.7 EFX03015.1 - 0.033 13.5 0.0 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 Phage protein GP46 LRR_9 PF14580.1 EFX03015.1 - 0.047 13.2 0.1 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.1 EFX03015.1 - 0.17 12.0 2.5 27 5.2 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich repeat RRM_1 PF00076.17 EFX03016.1 - 1.8e-52 174.8 0.1 5.1e-17 61.2 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03016.1 - 5.1e-50 167.3 0.0 2.9e-15 56.0 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03016.1 - 6.6e-34 115.5 0.0 5.9e-12 45.2 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFX03016.1 - 4.2e-06 26.4 0.0 0.035 13.8 0.0 3.3 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Lsm_interact PF05391.6 EFX03016.1 - 0.00011 21.5 0.0 0.00032 19.9 0.0 1.8 1 0 0 1 1 1 1 Lsm interaction motif Nup35_RRM PF05172.8 EFX03016.1 - 0.028 14.1 0.0 0.29 10.9 0.0 2.7 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Thioredoxin PF00085.15 EFX03016.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Ribonuclease_3 PF00636.21 EFX03018.1 - 1.5e-41 141.3 0.0 1.6e-21 76.8 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EFX03018.1 - 1.6e-24 86.3 0.3 2.1e-12 47.1 0.0 4.4 4 0 0 4 4 4 2 Ribonuclease-III-like ResIII PF04851.10 EFX03018.1 - 1.6e-11 44.4 0.1 1.1e-10 41.6 0.1 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFX03018.1 - 4.3e-11 42.5 0.0 9.6e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFX03018.1 - 0.066 13.3 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain SecA_DEAD PF07517.9 EFX03018.1 - 0.092 12.0 0.1 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain SNF2_N PF00176.18 EFX03018.1 - 0.1 11.3 0.2 0.28 9.9 0.1 1.5 1 1 0 1 1 1 0 SNF2 family N-terminal domain Flavi_DEAD PF07652.9 EFX03018.1 - 0.12 12.0 0.2 0.81 9.4 0.1 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain CPSase_L_D2 PF02786.12 EFX03019.1 - 1.3e-111 370.8 0.2 2e-83 278.8 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 EFX03019.1 - 6.5e-45 151.8 0.0 1.5e-44 150.6 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 EFX03019.1 - 7.3e-44 149.5 0.0 1.5e-43 148.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 EFX03019.1 - 5.2e-41 139.6 0.0 1.1e-40 138.5 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.14 EFX03019.1 - 2.2e-40 137.2 0.0 4.7e-40 136.1 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_L_chain PF00289.17 EFX03019.1 - 1.3e-36 125.0 0.1 1.4e-16 60.5 0.0 3.4 3 0 0 3 3 3 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 EFX03019.1 - 1.5e-36 125.8 0.2 1.2e-22 80.5 0.0 2.8 2 0 0 2 2 2 2 ATP-grasp domain OTCace PF00185.19 EFX03019.1 - 5.7e-32 110.7 0.0 1.6e-31 109.3 0.0 1.9 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.17 EFX03019.1 - 3.9e-22 77.9 0.0 1.4e-21 76.2 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain ATPgrasp_Ter PF15632.1 EFX03019.1 - 3.7e-21 75.2 0.0 4.7e-11 42.0 0.0 3.9 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EFX03019.1 - 2.3e-16 59.6 0.1 1.8e-07 30.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFX03019.1 - 1.3e-15 57.3 0.9 3e-07 30.0 0.0 2.9 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus Peptidase_C26 PF07722.8 EFX03019.1 - 5.4e-07 29.2 0.1 1.5e-05 24.5 0.0 2.5 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.9 EFX03019.1 - 9.7e-06 25.5 0.2 0.08 12.7 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain DJ-1_PfpI PF01965.19 EFX03019.1 - 0.00051 19.5 0.0 0.0014 18.1 0.0 1.7 1 0 0 1 1 1 1 DJ-1/PfpI family GARS_A PF01071.14 EFX03019.1 - 0.006 16.1 0.1 1.2 8.6 0.0 2.9 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Ish1 PF10281.4 EFX03019.1 - 0.21 11.7 0.0 2.1 8.4 0.0 2.5 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Ribonuc_L-PSP PF01042.16 EFX03020.1 - 7.3e-39 132.2 0.0 7.9e-39 132.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Peptidase_S8 PF00082.17 EFX03022.1 - 3.4e-21 75.6 1.7 5.4e-21 74.9 1.2 1.3 1 0 0 1 1 1 1 Subtilase family CdhD PF03599.11 EFX03022.1 - 0.091 11.2 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit ATP_bind_1 PF03029.12 EFX03023.1 - 5.4e-75 251.9 0.0 6.7e-75 251.6 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 EFX03023.1 - 0.0011 17.7 0.0 0.0023 16.7 0.0 1.4 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.18 EFX03023.1 - 0.016 14.6 0.0 0.033 13.5 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.7 EFX03023.1 - 0.038 13.0 0.0 0.1 11.7 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.1 EFX03023.1 - 0.045 13.2 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 EFX03023.1 - 0.058 14.2 2.2 0.4 11.5 0.2 2.7 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 EFX03023.1 - 0.17 11.8 0.1 0.95 9.4 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF1752 PF08550.5 EFX03024.1 - 3.8e-10 39.1 3.8 7e-10 38.3 2.6 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) FAD_binding_4 PF01565.18 EFX03025.1 - 2.6e-12 46.4 0.4 4.3e-12 45.6 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 EFX03025.1 - 1.6e-05 24.6 0.2 2.6e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase HCR PF07111.7 EFX03026.1 - 0.00024 19.2 4.2 0.00028 19.0 2.9 1.0 1 0 0 1 1 1 1 Alpha helical coiled-coil rod protein (HCR) Phage_lysis PF03245.8 EFX03026.1 - 0.0077 16.2 13.8 0.44 10.5 4.6 2.5 1 1 0 2 2 2 2 Bacteriophage Rz lysis protein End3 PF12761.2 EFX03026.1 - 0.042 13.5 2.9 0.068 12.8 2.0 1.4 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Exonuc_VII_S PF02609.11 EFX03026.1 - 0.045 13.5 0.3 0.14 11.9 0.2 1.8 2 0 0 2 2 2 0 Exonuclease VII small subunit Snapin_Pallidin PF14712.1 EFX03026.1 - 0.2 11.9 3.0 0.33 11.2 0.6 2.3 3 0 0 3 3 3 0 Snapin/Pallidin GAS PF13851.1 EFX03026.1 - 0.21 10.7 3.5 0.19 10.8 1.4 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding YicC_N PF03755.8 EFX03026.1 - 0.37 10.7 4.6 0.27 11.1 1.4 1.9 1 1 1 2 2 2 0 YicC-like family, N-terminal region FlgN PF05130.7 EFX03026.1 - 0.38 10.9 9.7 0.094 12.9 3.7 2.0 1 1 1 2 2 2 0 FlgN protein SlyX PF04102.7 EFX03026.1 - 2.5 8.5 9.0 1.1 9.7 0.1 3.5 2 1 2 4 4 4 0 SlyX Kinetocho_Slk19 PF12709.2 EFX03026.1 - 4 7.5 6.4 2.3 8.3 0.6 2.6 2 1 1 3 3 3 0 Central kinetochore-associated Met_10 PF02475.11 EFX03027.1 - 1.2e-63 214.3 0.0 1.7e-63 213.8 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein zf-C2H2 PF00096.21 EFX03028.1 - 0.017 15.3 3.0 0.017 15.3 2.1 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX03028.1 - 1.8 9.0 13.6 0.15 12.4 0.6 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger ELO PF01151.13 EFX03029.1 - 1.3e-62 211.3 18.6 1.5e-62 211.1 12.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family PTPA PF03095.10 EFX03030.1 - 6.7e-99 330.8 0.0 9.7e-99 330.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pmp3 PF01679.12 EFX03032.1 - 1.9e-18 65.9 7.7 2.3e-18 65.6 5.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator F-box PF00646.28 EFX03033.1 - 0.00024 20.6 0.2 0.00083 18.9 0.1 2.0 1 0 0 1 1 1 1 F-box domain TatD_DNase PF01026.16 EFX03034.1 - 2.5e-31 108.8 0.0 3.5e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase PC4 PF02229.11 EFX03035.1 - 2.3e-21 74.7 0.1 3.7e-21 74.1 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) ComZ PF10815.3 EFX03035.1 - 0.044 13.5 0.2 0.24 11.1 0.1 2.1 1 1 1 2 2 2 0 ComZ Pkinase PF00069.20 EFX03036.1 - 1.1e-67 227.9 0.0 1.6e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03036.1 - 1e-38 132.8 0.0 1.5e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX03036.1 - 1.6e-08 33.8 0.0 2.6e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like POLO_box PF00659.13 EFX03036.1 - 4.4e-06 26.5 0.0 0.0025 17.7 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kdo PF06293.9 EFX03036.1 - 0.00095 18.2 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SR-25 PF10500.4 EFX03036.1 - 7.5 5.9 46.6 0.12 11.8 11.7 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 EFX03036.1 - 7.9 4.6 18.1 7 4.7 8.6 2.1 2 0 0 2 2 2 0 Transmembrane protein Med3 PF11593.3 EFX03037.1 - 1.9 7.6 26.6 3.5 6.7 18.4 1.6 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal Glyco_hydro_28 PF00295.12 EFX03038.1 - 3.4e-27 95.2 4.0 4.4e-27 94.8 2.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.2 EFX03038.1 - 1.1e-05 25.6 12.3 1.5e-05 25.2 7.2 2.1 1 1 1 2 2 2 1 Pectate lyase superfamily protein INSIG PF07281.7 EFX03039.1 - 5.9e-48 162.7 1.1 2.2e-47 160.9 0.8 1.9 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) Nepo_coat PF03391.10 EFX03039.1 - 0.5 9.6 8.6 0.48 9.6 3.3 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, central domain Toxin_16 PF07945.6 EFX03040.1 - 0.7 9.6 8.2 0.54 9.9 1.8 2.7 2 0 0 2 2 2 0 Janus-atracotoxin BRCT PF00533.21 EFX03041.1 - 0.0002 21.4 0.0 0.00043 20.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain p450 PF00067.17 EFX03043.1 - 2.3e-48 164.8 0.0 6.2e-48 163.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 AA_permease_2 PF13520.1 EFX03044.1 - 6.6e-42 143.5 45.9 3.4e-26 91.7 13.5 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.16 EFX03044.1 - 2.2e-20 72.4 42.0 8e-11 40.9 15.4 2.3 1 1 1 2 2 2 2 Amino acid permease Synaptobrevin PF00957.16 EFX03045.1 - 2.5e-28 97.4 0.0 3.3e-28 97.1 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 EFX03045.1 - 8.7e-22 76.4 0.0 1.4e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain SpoIIAA-like PF11964.3 EFX03045.1 - 0.094 13.0 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 SpoIIAA-like Abhydrolase_3 PF07859.8 EFX03046.1 - 3.1e-40 138.0 0.1 1.1e-30 106.7 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 EFX03046.1 - 2.2e-11 43.0 0.0 6.8e-11 41.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 EFX03046.1 - 0.00057 19.6 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 EFX03046.1 - 0.0027 16.5 0.4 0.1 11.2 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Glyco_hydro_28 PF00295.12 EFX03047.1 - 2.1e-22 79.5 2.8 2.8e-22 79.1 1.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.2 EFX03047.1 - 0.00013 22.1 15.1 0.00034 20.8 10.5 1.7 1 1 0 1 1 1 1 Pectate lyase superfamily protein p450 PF00067.17 EFX03048.1 - 3.4e-27 95.1 0.0 5.4e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Pyridoxal_deC PF00282.14 EFX03049.1 - 4.7e-101 337.9 0.0 6e-101 337.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain AIRS PF00586.19 EFX03049.1 - 0.021 15.0 0.1 0.11 12.7 0.0 2.2 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain Fe-ADH_2 PF13685.1 EFX03049.1 - 0.039 13.2 0.1 0.069 12.4 0.1 1.3 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase ThiF PF00899.16 EFX03050.1 - 1.6e-10 40.9 0.0 1.4e-09 37.8 0.0 2.4 2 0 0 2 2 2 1 ThiF family DUF466 PF04328.8 EFX03050.1 - 0.099 12.4 0.8 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF466) Complex1_LYR_1 PF13232.1 EFX03051.1 - 2.9e-21 75.4 4.2 3.9e-21 75.0 2.9 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 EFX03051.1 - 1e-19 70.0 5.1 1.3e-19 69.6 3.5 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) VitD-bind_III PF09164.5 EFX03051.1 - 0.15 11.6 0.1 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Ribosomal_S13_N PF08069.7 EFX03052.1 - 1.6e-25 88.7 0.1 3.7e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain RRM_1 PF00076.17 EFX03052.1 - 2.6e-25 87.8 0.0 5.8e-13 48.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S15 PF00312.17 EFX03052.1 - 1e-21 76.4 0.0 2.1e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 RRM_5 PF13893.1 EFX03052.1 - 7.8e-14 51.2 0.0 3.3e-05 23.6 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03052.1 - 1.9e-13 50.2 0.0 2.1e-05 24.3 0.0 3.5 4 0 0 4 4 4 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PAX PF00292.13 EFX03052.1 - 0.031 13.9 0.1 0.087 12.5 0.1 1.7 1 0 0 1 1 1 0 'Paired box' domain TPR_12 PF13424.1 EFX03053.1 - 4.5e-05 23.2 0.7 0.015 15.1 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX03053.1 - 0.011 15.3 0.0 1.7 8.3 0.0 2.8 1 1 1 2 2 2 0 TPR repeat APG5 PF04106.7 EFX03054.1 - 5.7e-42 143.4 0.0 7.7e-41 139.7 0.0 2.1 1 1 0 1 1 1 1 Autophagy protein Apg5 CorA PF01544.13 EFX03055.1 - 1.1e-11 44.3 0.1 2.4e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.11 EFX03056.1 - 1.8e-32 112.4 32.5 1.2e-31 109.7 9.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily ATP_synt_H PF05493.8 EFX03056.1 - 7.6 6.6 8.7 13 5.9 0.3 3.6 3 0 0 3 3 3 0 ATP synthase subunit H Nse4_C PF08743.5 EFX03057.1 - 2e-29 101.4 0.0 5.1e-29 100.1 0.0 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 EFX03057.1 - 6.1e-13 48.3 0.4 2.5e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE Peroxin-3 PF04882.7 EFX03058.1 - 9.9e-125 416.6 0.0 1.3e-124 416.2 0.0 1.2 1 0 0 1 1 1 1 Peroxin-3 Nab2 PF11517.3 EFX03059.1 - 0.016 15.3 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.1 EFX03059.1 - 0.39 10.7 11.7 0.54 10.3 4.0 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type DUF4175 PF13779.1 EFX03059.1 - 1.5 6.4 21.1 2.5 5.6 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAT1 PF09770.4 EFX03059.1 - 4.8 5.3 18.8 6.4 4.8 13.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_33 PF13671.1 EFX03060.1 - 0.00042 20.2 0.0 0.003 17.4 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 EFX03060.1 - 0.00069 19.7 0.1 0.0021 18.1 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EFX03060.1 - 0.0035 16.8 0.1 0.0095 15.3 0.0 1.7 2 0 0 2 2 2 1 AAA-like domain AAA_17 PF13207.1 EFX03060.1 - 0.0045 17.7 0.0 0.037 14.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EFX03060.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 EFX03060.1 - 0.033 14.3 0.0 0.85 9.8 0.0 2.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFX03060.1 - 0.044 13.7 0.0 0.13 12.1 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 EFX03060.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Sugar_tr PF00083.19 EFX03061.1 - 7.1e-121 403.9 27.3 8.1e-121 403.7 18.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03061.1 - 2.3e-18 66.0 50.1 1.8e-13 49.9 14.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF3154 PF11351.3 EFX03061.1 - 0.091 12.5 1.1 0.74 9.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3154) MFS_1 PF07690.11 EFX03062.1 - 3.7e-48 164.0 34.8 3.7e-48 164.0 24.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 EFX03062.1 - 0.00057 18.0 2.6 0.00082 17.5 0.1 2.1 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Pneumo_att_G PF05539.6 EFX03062.1 - 1.7 7.9 3.7 2.3 7.4 2.6 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Glyco_hydro_88 PF07470.8 EFX03063.1 - 1.2e-80 271.1 0.2 1.4e-80 270.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Miro PF08477.8 EFX03064.1 - 5.3e-31 107.5 0.0 6e-18 65.4 0.0 3.1 4 0 0 4 4 2 2 Miro-like protein EF_assoc_1 PF08355.7 EFX03064.1 - 1.5e-30 104.2 0.1 4e-30 102.9 0.1 1.8 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.7 EFX03064.1 - 2.5e-27 94.4 0.0 9.4e-27 92.6 0.0 1.9 2 0 0 2 2 2 1 EF hand associated WD40 PF00400.27 EFX03064.1 - 2.5e-18 65.1 4.6 7e-06 25.7 0.1 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Ras PF00071.17 EFX03064.1 - 3.5e-16 58.9 0.0 7.1e-12 45.0 0.0 2.3 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.18 EFX03064.1 - 1e-06 28.7 0.0 0.0033 17.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.1 EFX03064.1 - 1.3e-06 28.4 0.5 0.0085 16.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair AAA_16 PF13191.1 EFX03064.1 - 8.8e-06 25.8 0.0 0.088 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain EF-hand_1 PF00036.27 EFX03064.1 - 1.8e-05 23.6 3.0 0.13 11.6 0.1 2.9 2 0 0 2 2 2 2 EF hand AAA_29 PF13555.1 EFX03064.1 - 3.2e-05 23.3 0.0 0.032 13.7 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain EF-hand_6 PF13405.1 EFX03064.1 - 3.7e-05 23.2 3.4 0.19 11.6 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain Dynamin_N PF00350.18 EFX03064.1 - 0.00031 20.5 0.1 1.4 8.7 0.0 3.0 2 1 1 3 3 3 2 Dynamin family AAA_22 PF13401.1 EFX03064.1 - 0.00036 20.6 0.0 0.33 11.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 EFX03064.1 - 0.00072 19.8 0.0 1.4 9.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.1 EFX03064.1 - 0.00093 18.6 0.1 1.2 8.4 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_24 PF13479.1 EFX03064.1 - 0.002 17.7 0.0 0.039 13.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFX03064.1 - 0.012 15.4 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EFX03064.1 - 0.014 15.5 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 EFX03064.1 - 0.021 14.8 0.0 5.7 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EFX03064.1 - 0.024 13.8 0.0 1.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 NACHT PF05729.7 EFX03064.1 - 0.026 14.1 0.1 4 7.0 0.0 2.6 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.7 EFX03064.1 - 0.047 12.7 0.0 1.1 8.3 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin IKI3 PF04762.7 EFX03064.1 - 0.061 11.1 0.0 0.089 10.5 0.0 1.1 1 0 0 1 1 1 0 IKI3 family MobB PF03205.9 EFX03064.1 - 0.074 12.7 0.0 0.33 10.6 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 EFX03064.1 - 0.13 12.5 0.0 5.8 7.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain EF-hand_10 PF14788.1 EFX03064.1 - 0.14 11.7 0.1 0.35 10.5 0.1 1.6 1 0 0 1 1 1 0 EF hand DUF815 PF05673.8 EFX03064.1 - 0.15 10.9 0.0 2.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ArgK PF03308.11 EFX03064.1 - 0.16 10.7 0.0 4.9 5.8 0.0 2.3 2 0 0 2 2 2 0 ArgK protein Viral_helicase1 PF01443.13 EFX03064.1 - 0.17 11.4 0.0 3.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase EF-hand_8 PF13833.1 EFX03064.1 - 0.22 11.1 3.1 0.85 9.2 0.5 2.4 2 0 0 2 2 2 0 EF-hand domain pair Septin PF00735.13 EFX03064.1 - 0.22 10.4 0.0 0.77 8.7 0.0 1.7 2 0 0 2 2 2 0 Septin AAA_10 PF12846.2 EFX03064.1 - 0.26 10.7 0.0 16 4.8 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain cobW PF02492.14 EFX03064.1 - 0.27 10.6 0.2 6.4 6.1 0.0 3.1 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain eIF2A PF08662.6 EFX03064.1 - 0.37 10.4 0.0 1.8 8.1 0.0 1.9 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A MCM PF00493.18 EFX03064.1 - 0.49 9.1 0.0 11 4.6 0.0 2.1 2 0 0 2 2 2 0 MCM2/3/5 family EF-hand_5 PF13202.1 EFX03064.1 - 0.92 8.9 11.2 2.2 7.7 1.2 3.1 3 0 0 3 3 2 0 EF hand zf-primase PF09329.6 EFX03066.1 - 0.22 11.1 2.6 0.35 10.5 0.1 2.2 2 0 0 2 2 2 0 Primase zinc finger Peptidase_C2 PF00648.16 EFX03067.1 - 4.1e-58 196.7 2.4 5.7e-39 133.8 0.5 2.3 2 0 0 2 2 2 2 Calpain family cysteine protease PPR_3 PF13812.1 EFX03067.1 - 0.00021 21.3 12.9 0.04 14.2 0.1 6.5 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR PF01535.15 EFX03067.1 - 0.16 12.0 0.2 5.1 7.2 0.0 3.6 5 0 0 5 5 5 0 PPR repeat DUF2413 PF10310.4 EFX03067.1 - 1.9 7.2 6.0 3.7 6.2 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Methyltransf_11 PF08241.7 EFX03068.1 - 2e-09 37.8 0.0 3.3e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03068.1 - 6.7e-05 23.2 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03068.1 - 0.0054 17.2 0.0 0.0098 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03068.1 - 0.0068 16.0 0.0 0.0094 15.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX03068.1 - 0.016 14.8 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 EFX03068.1 - 0.046 13.7 0.1 0.09 12.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF4081 PF13312.1 EFX03068.1 - 0.048 13.5 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) CheR PF01739.13 EFX03068.1 - 0.15 11.3 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MFS_1 PF07690.11 EFX03069.1 - 4e-27 94.8 45.1 1.7e-26 92.7 31.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX03069.1 - 7.9e-11 41.1 11.3 7.9e-11 41.1 7.8 3.3 3 0 0 3 3 3 2 Sugar (and other) transporter Profilin PF00235.14 EFX03070.1 - 1.8e-35 121.6 0.3 2e-35 121.5 0.2 1.0 1 0 0 1 1 1 1 Profilin Cyt-b5 PF00173.23 EFX03072.1 - 2.1e-17 62.7 0.0 5.8e-17 61.2 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 EFX03072.1 - 3.6e-17 62.6 11.2 3.6e-17 62.6 7.8 2.2 1 1 1 2 2 2 1 Fatty acid desaturase Leu_zip PF15294.1 EFX03073.1 - 0.23 10.5 9.3 0.02 13.9 2.0 2.1 2 0 0 2 2 2 0 Leucine zipper Mnd1 PF03962.10 EFX03073.1 - 0.42 10.2 10.4 1.1 8.9 1.7 2.6 2 0 0 2 2 2 0 Mnd1 family NYD-SP28_assoc PF14775.1 EFX03073.1 - 0.42 10.3 4.5 2 8.1 0.3 2.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF904 PF06005.7 EFX03073.1 - 2 8.7 11.7 4.5 7.6 0.6 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF904) GAS PF13851.1 EFX03073.1 - 3.5 6.7 12.8 1.8 7.6 2.0 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF972 PF06156.8 EFX03073.1 - 5.6 7.3 6.9 30 5.0 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Ribosomal_L22e PF01776.12 EFX03075.1 - 3.2e-47 159.1 0.8 3.9e-47 158.8 0.6 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family tRNA_anti-like PF12869.2 EFX03075.1 - 0.032 13.7 0.2 0.052 13.0 0.1 1.4 1 1 0 1 1 1 0 tRNA_anti-like Pectinesterase PF01095.14 EFX03076.1 - 7.4e-38 129.8 6.3 1.4e-31 109.2 1.3 2.1 1 1 1 2 2 2 2 Pectinesterase Sugar_tr PF00083.19 EFX03077.1 - 7.3e-76 255.5 19.4 8.8e-76 255.2 13.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03077.1 - 1e-13 50.7 37.6 2.8e-08 32.8 13.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily CN_hydrolase PF00795.17 EFX03078.1 - 2.1e-14 53.3 0.0 2.1e-08 33.7 0.0 2.3 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase NAD_binding_4 PF07993.7 EFX03079.1 - 1.1e-30 106.4 0.0 4.5e-30 104.3 0.0 2.1 3 0 0 3 3 3 1 Male sterility protein AMP-binding PF00501.23 EFX03079.1 - 2.1e-26 92.2 0.0 6.3e-26 90.7 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.16 EFX03079.1 - 2.1e-09 37.1 0.0 4.2e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EFX03079.1 - 1.9e-05 23.7 0.1 0.0011 17.9 0.0 2.4 2 0 0 2 2 2 1 RmlD substrate binding domain PP-binding PF00550.20 EFX03079.1 - 2e-05 24.7 0.0 5.4e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.20 EFX03079.1 - 0.015 15.2 1.3 0.054 13.3 0.4 2.4 2 1 0 2 2 2 0 short chain dehydrogenase KR PF08659.5 EFX03079.1 - 0.12 11.9 1.1 0.48 10.0 0.1 2.4 3 0 0 3 3 3 0 KR domain ABC_membrane PF00664.18 EFX03081.1 - 3.9e-14 52.7 4.0 6e-14 52.1 2.8 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EFX03081.1 - 6.5e-07 29.7 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 EFX03081.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX03081.1 - 0.017 15.0 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.10 EFX03081.1 - 0.094 11.3 0.1 0.16 10.5 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Arch_ATPase PF01637.13 EFX03081.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 EFX03081.1 - 0.12 11.8 0.1 0.46 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain PduV-EutP PF10662.4 EFX03081.1 - 0.13 11.7 0.1 3.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sugarporin_N PF11471.3 EFX03081.1 - 7.2 6.3 11.1 3.7 7.2 1.8 3.3 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension Spc24 PF08286.6 EFX03083.1 - 1.8e-40 137.2 0.2 1.2e-37 128.1 0.0 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 MAD PF05557.8 EFX03083.1 - 0.0016 16.6 1.5 0.0028 15.8 1.0 1.3 1 0 0 1 1 1 1 Mitotic checkpoint protein Nsp1_C PF05064.8 EFX03083.1 - 0.0033 17.0 1.3 0.65 9.6 0.0 2.3 2 0 0 2 2 2 1 Nsp1-like C-terminal region Reo_sigmaC PF04582.7 EFX03083.1 - 0.014 14.6 1.9 0.018 14.2 1.3 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Prefoldin_2 PF01920.15 EFX03083.1 - 0.018 14.7 5.9 0.57 9.9 0.8 2.2 2 0 0 2 2 2 0 Prefoldin subunit HOOK PF05622.7 EFX03083.1 - 0.045 11.5 3.6 0.06 11.1 2.5 1.1 1 0 0 1 1 1 0 HOOK protein DUF948 PF06103.6 EFX03083.1 - 0.049 13.4 3.4 0.78 9.6 0.4 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Blo-t-5 PF11642.3 EFX03083.1 - 0.089 12.5 1.1 0.18 11.5 0.8 1.5 1 1 0 1 1 1 0 Mite allergen Blo t 5 DUF4164 PF13747.1 EFX03083.1 - 0.093 12.8 10.8 0.6 10.2 7.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) Vps5 PF09325.5 EFX03083.1 - 0.1 11.8 6.0 0.21 10.8 4.2 1.4 1 1 0 1 1 1 0 Vps5 C terminal like DUF4208 PF13907.1 EFX03083.1 - 0.11 12.7 0.2 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) DUF4254 PF14063.1 EFX03083.1 - 0.11 12.1 3.6 0.21 11.1 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4254) Rab5-bind PF09311.6 EFX03083.1 - 0.14 11.9 10.1 0.14 12.0 3.4 2.5 1 1 1 3 3 3 0 Rabaptin-like protein DUF3584 PF12128.3 EFX03083.1 - 0.15 9.3 6.7 0.2 8.9 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.4 EFX03083.1 - 0.19 11.6 7.4 0.37 10.6 5.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 EFX03083.1 - 0.25 10.3 6.7 0.44 9.5 4.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 EAP30 PF04157.11 EFX03083.1 - 0.36 9.9 7.9 0.62 9.1 5.3 1.5 1 1 1 2 2 2 0 EAP30/Vps36 family TMF_DNA_bd PF12329.3 EFX03083.1 - 0.38 10.5 10.4 0.3 10.9 1.0 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding HAUS-augmin3 PF14932.1 EFX03083.1 - 0.43 9.7 7.5 0.59 9.2 5.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Prominin PF05478.6 EFX03083.1 - 0.43 8.0 5.5 0.54 7.7 3.8 1.0 1 0 0 1 1 1 0 Prominin FUSC PF04632.7 EFX03083.1 - 0.45 8.8 5.5 0.53 8.6 3.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Viral_P18 PF04521.8 EFX03083.1 - 1.1 8.7 7.8 0.34 10.3 1.7 2.1 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein SlyX PF04102.7 EFX03083.1 - 1.2 9.5 5.2 22 5.5 0.1 2.5 2 1 0 2 2 2 0 SlyX Troponin PF00992.15 EFX03083.1 - 1.3 9.0 5.9 1.9 8.5 4.1 1.2 1 0 0 1 1 1 0 Troponin DUF3138 PF11336.3 EFX03083.1 - 9.4 4.2 8.1 17 3.4 5.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) DSPc PF00782.15 EFX03084.1 - 3.5e-10 39.5 0.0 6.8e-10 38.6 0.0 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PNPOx_C PF10590.4 EFX03085.1 - 2.7e-20 71.5 1.4 2.7e-20 71.5 1.0 1.9 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 EFX03085.1 - 3.2e-11 43.0 0.0 1.1e-10 41.4 0.0 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CM_2 PF01817.16 EFX03086.1 - 6.2e-06 26.2 2.4 0.0011 18.9 0.0 3.4 3 1 0 3 3 3 2 Chorismate mutase type II Pkinase PF00069.20 EFX03087.1 - 9.9e-59 198.5 0.0 1.5e-58 198.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03087.1 - 1.4e-38 132.4 0.0 1.9e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX03087.1 - 1.6e-05 23.9 0.0 3.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Activator_LAG-3 PF11498.3 EFX03087.1 - 2.6 6.6 11.3 4.1 6.0 7.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 E1_dh PF00676.15 EFX03088.1 - 1.6e-114 381.6 0.3 2.1e-114 381.2 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 EFX03088.1 - 0.0019 17.2 0.0 0.0033 16.4 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Hemocyanin_C PF03723.9 EFX03088.1 - 0.034 13.2 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 Hemocyanin, ig-like domain BMC PF00936.14 EFX03088.1 - 0.061 13.0 0.4 1.2 8.8 0.0 2.8 3 0 0 3 3 3 0 BMC domain PMT PF02366.13 EFX03089.1 - 2.1e-79 266.3 18.0 4.3e-79 265.3 12.5 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EFX03089.1 - 4.5e-18 65.4 0.0 2.1e-16 59.9 0.0 2.1 1 1 1 2 2 2 2 MIR domain zf-UBR PF02207.15 EFX03090.1 - 1.1e-16 60.2 5.1 1.1e-16 60.2 3.5 3.2 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) SMK-1 PF04802.10 EFX03091.1 - 9.5e-78 260.1 1.9 2e-77 259.0 0.3 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 YL1 PF05764.8 EFX03091.1 - 0.31 10.6 6.7 0.51 9.8 4.7 1.3 1 0 0 1 1 1 0 YL1 nuclear protein TruB_N PF01509.13 EFX03092.1 - 1.2e-42 145.6 0.0 2.4e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) Mito_carr PF00153.22 EFX03093.1 - 8.8e-56 185.6 0.3 1e-18 66.7 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_8 PF01501.15 EFX03093.1 - 8.8e-19 67.8 0.0 1.3e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 zf-MIZ PF02891.15 EFX03094.1 - 6.3e-07 28.8 12.5 1.9e-05 24.0 0.0 2.6 1 1 1 2 2 2 2 MIZ/SP-RING zinc finger HAD_2 PF13419.1 EFX03095.1 - 4e-23 82.5 0.0 5.5e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFX03095.1 - 0.048 14.0 0.0 0.12 12.8 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HEAT PF02985.17 EFX03096.1 - 1.7e-14 52.4 13.0 0.001 18.9 0.0 10.2 11 0 0 11 11 11 2 HEAT repeat HEAT_2 PF13646.1 EFX03096.1 - 2.9e-13 49.9 11.0 2.4e-05 24.4 0.0 7.9 3 2 5 8 8 8 5 HEAT repeats HEAT_EZ PF13513.1 EFX03096.1 - 8.4e-13 48.3 10.3 7.3e-07 29.5 0.0 8.7 9 1 1 10 10 10 2 HEAT-like repeat IBN_N PF03810.14 EFX03096.1 - 6.3e-09 35.6 4.4 1.4e-07 31.2 1.0 4.1 5 0 0 5 5 5 1 Importin-beta N-terminal domain CLASP_N PF12348.3 EFX03096.1 - 6e-05 22.5 0.1 1.5 8.1 0.0 5.1 4 1 2 6 6 6 2 CLASP N terminal Fungal_trans PF04082.13 EFX03097.1 - 9.1e-21 73.8 0.2 1.4e-20 73.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyridox_oxase_2 PF12766.2 EFX03097.1 - 2e-18 66.5 0.0 3.9e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Ribosomal_S18 PF01084.15 EFX03098.1 - 8.2e-12 44.8 0.0 1.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 DUF1501 PF07394.7 EFX03098.1 - 0.035 12.9 0.5 0.045 12.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) MFS_1 PF07690.11 EFX03099.1 - 1.8e-25 89.4 28.5 2.7e-19 69.0 9.3 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 EFX03099.1 - 0.003 16.0 28.3 0.0062 15.0 0.1 3.8 2 2 1 3 3 3 2 Vacuole effluxer Atg22 like Tom22 PF04281.8 EFX03100.1 - 2.1e-40 137.4 0.0 2.6e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 FYVE_2 PF02318.11 EFX03101.1 - 0.0025 17.7 26.5 0.036 13.9 2.3 3.8 4 0 0 4 4 4 3 FYVE-type zinc finger EF-hand_4 PF12763.2 EFX03102.1 - 4e-25 87.5 0.0 1.5e-13 50.3 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 EFX03102.1 - 0.00017 20.6 0.1 0.36 10.2 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 EFX03102.1 - 0.00052 20.0 0.0 0.88 9.7 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 EFX03102.1 - 0.008 15.9 0.1 8.8 6.5 0.0 3.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.1 EFX03102.1 - 0.088 12.4 0.0 6.4 6.4 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain pair WD40 PF00400.27 EFX03104.1 - 5e-39 130.8 1.1 1.8e-09 37.1 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EFX03104.1 - 7e-28 96.3 0.2 1.7e-27 95.0 0.1 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex zf-DHHC PF01529.15 EFX03105.1 - 1.6e-37 128.5 4.0 1.6e-37 128.5 2.7 1.9 2 1 0 2 2 2 1 DHHC palmitoyltransferase Gifsy-2 PF13856.1 EFX03105.1 - 0.072 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage zf-RING_3 PF14369.1 EFX03106.1 - 0.11 12.5 2.5 0.28 11.2 1.0 2.3 2 0 0 2 2 2 0 zinc-finger DNA_pol_B PF00136.16 EFX03107.1 - 2.3e-106 356.3 0.9 3.5e-106 355.7 0.6 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 EFX03107.1 - 2.9e-62 209.3 0.2 5e-62 208.6 0.1 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 EFX03107.1 - 1.3e-35 122.8 0.0 1.9e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 EFX03107.1 - 1.4e-23 82.4 12.5 2.3e-23 81.7 7.0 2.7 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal 2OG-FeII_Oxy_2 PF13532.1 EFX03108.1 - 2.3e-25 89.5 0.0 3.5e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.15 EFX03108.1 - 1e-23 84.1 0.0 3.3e-23 82.4 0.0 1.8 1 1 0 1 1 1 1 Isochorismatase family GST_C_3 PF14497.1 EFX03108.1 - 3.4e-06 27.4 0.0 8.8e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFX03108.1 - 0.027 14.3 0.0 0.062 13.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NAD_binding_1 PF00175.16 EFX03109.1 - 1.4e-27 96.3 0.0 2.1e-27 95.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFX03109.1 - 2.4e-27 94.9 0.0 3.6e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EFX03109.1 - 0.00037 20.4 0.0 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 EFX03109.1 - 0.015 15.2 0.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain RNase_PH PF01138.16 EFX03110.1 - 5.1e-13 49.4 0.0 9.3e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 NAD_binding_2 PF03446.10 EFX03112.1 - 5.1e-27 94.7 1.0 8e-27 94.0 0.7 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFX03112.1 - 1.6e-06 28.1 0.4 4.2e-06 26.8 0.3 1.7 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 EFX03112.1 - 0.00097 19.5 0.1 0.0037 17.6 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 EFX03112.1 - 0.0074 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Thymidylate_kin PF02223.12 EFX03112.1 - 0.058 12.7 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase DNA_ligase_A_M PF01068.16 EFX03113.1 - 5e-40 137.0 0.0 7.4e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFX03113.1 - 1.9e-36 125.5 0.0 3.2e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EFX03113.1 - 1.5e-15 57.3 0.0 5.6e-15 55.5 0.0 2.1 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.21 EFX03113.1 - 1.1e-07 31.8 0.0 5.7e-05 23.1 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_OB_2 PF14743.1 EFX03113.1 - 0.053 13.1 1.1 2 8.1 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain mRNA_cap_enzyme PF01331.14 EFX03113.1 - 0.078 12.6 0.0 0.56 9.8 0.0 2.2 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain DUF2011 PF09428.5 EFX03113.1 - 0.078 12.8 1.9 0.16 11.8 1.3 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) Utp14 PF04615.8 EFX03114.1 - 7.3e-149 497.2 79.2 7.3e-149 497.2 54.9 2.1 1 1 1 2 2 2 1 Utp14 protein TRP PF06011.7 EFX03115.1 - 2.6e-64 217.4 27.1 9.6e-64 215.5 16.4 3.0 1 1 1 2 2 2 1 Transient receptor potential (TRP) ion channel Dioxygenase_C PF00775.16 EFX03115.1 - 1.2e-52 177.8 0.0 2.1e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase TRP_N PF14558.1 EFX03115.1 - 1e-15 57.9 0.2 2.7e-07 30.7 0.0 2.3 1 1 1 2 2 2 2 ML-like domain Dioxygenase_N PF04444.9 EFX03115.1 - 1.3e-15 57.1 0.0 4.9e-15 55.2 0.0 1.9 2 0 0 2 2 2 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 EFX03115.1 - 0.0021 18.0 0.0 0.0054 16.7 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain C2 PF00168.25 EFX03116.1 - 0.0027 17.4 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain Mis12 PF05859.7 EFX03117.1 - 4.7e-39 133.4 0.0 7.9e-39 132.7 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein BESS PF02944.15 EFX03117.1 - 0.055 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 BESS motif Myb_DNA-bind_6 PF13921.1 EFX03118.1 - 0.0001 22.3 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFX03118.1 - 0.066 13.2 0.1 0.066 13.2 0.1 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain Rap1_C PF11626.3 EFX03118.1 - 0.093 12.6 0.3 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain 2_5_RNA_ligase2 PF13563.1 EFX03119.1 - 3e-21 75.7 0.0 3.7e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Dynamin_N PF00350.18 EFX03120.1 - 3.1e-16 59.6 0.8 4.7e-16 59.0 0.0 1.7 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 EFX03120.1 - 8.4e-09 35.4 0.1 3.9e-08 33.2 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFX03120.1 - 3e-07 30.0 1.0 2.4e-06 27.1 0.8 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IIGP PF05049.8 EFX03120.1 - 0.047 12.4 0.0 0.1 11.3 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_18 PF13238.1 EFX03120.1 - 0.056 13.7 0.1 0.34 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFX03120.1 - 0.063 12.8 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Miro PF08477.8 EFX03120.1 - 0.079 13.4 0.1 1.3 9.5 0.1 2.4 1 1 0 1 1 1 0 Miro-like protein PduV-EutP PF10662.4 EFX03120.1 - 0.12 11.8 0.1 16 4.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ERG2_Sigma1R PF04622.7 EFX03121.1 - 2.8e-93 311.1 0.9 3.1e-93 310.9 0.6 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein La PF05383.12 EFX03122.1 - 4.7e-14 51.9 0.0 7.4e-14 51.2 0.0 1.3 1 0 0 1 1 1 1 La domain RRM_6 PF14259.1 EFX03122.1 - 1.4e-06 28.1 0.0 3.7e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX03122.1 - 1.6e-06 27.6 0.1 3.9e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03122.1 - 0.041 13.7 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sel1 PF08238.7 EFX03123.1 - 2e-36 123.5 30.5 1.5e-05 25.4 0.1 7.4 7 0 0 7 7 7 7 Sel1 repeat Patatin PF01734.17 EFX03124.1 - 1.1e-21 77.7 0.0 3.5e-21 76.0 0.0 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Polysacc_syn_2C PF08485.5 EFX03124.1 - 0.18 11.3 1.0 0.4 10.2 0.1 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein C-terminal 3-PAP PF12578.3 EFX03124.1 - 0.33 10.8 4.7 2.7 7.8 0.4 2.3 2 0 0 2 2 2 0 Myotubularin-associated protein TPR_11 PF13414.1 EFX03125.1 - 3.4e-37 125.8 24.0 2.3e-12 46.3 3.5 7.4 5 2 2 7 7 7 6 TPR repeat TPR_1 PF00515.23 EFX03125.1 - 2.5e-31 105.9 17.1 9.2e-07 28.2 0.1 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.12 EFX03125.1 - 2.6e-30 101.8 24.3 2.9e-05 23.6 0.2 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.1 EFX03125.1 - 5.3e-25 85.2 6.2 5.6e-05 22.6 0.9 8.6 9 0 0 9 9 9 4 Tetratricopeptide repeat Apc3 PF12895.2 EFX03125.1 - 4.4e-24 84.4 18.9 4.3e-16 58.8 0.0 4.8 4 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EFX03125.1 - 1.8e-19 69.4 27.0 1.4e-05 24.9 0.0 7.9 4 3 5 9 9 9 6 Tetratricopeptide repeat TPR_19 PF14559.1 EFX03125.1 - 2.4e-18 66.2 13.1 0.00017 21.8 3.1 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX03125.1 - 4.4e-18 64.1 28.7 0.033 14.8 0.0 11.0 6 2 6 12 12 11 7 Tetratricopeptide repeat TPR_17 PF13431.1 EFX03125.1 - 3.3e-17 61.1 12.3 0.028 14.5 0.2 8.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 EFX03125.1 - 2.1e-15 56.9 34.7 1.9e-06 28.3 1.2 8.1 6 2 2 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.1 EFX03125.1 - 8.8e-15 53.2 17.1 0.0042 16.7 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.1 EFX03125.1 - 3.6e-09 36.4 16.9 0.094 13.2 0.0 8.9 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFX03125.1 - 0.0039 17.0 14.5 4.1 7.3 1.6 6.0 4 2 2 6 6 6 2 Tetratricopeptide repeat FAT PF02259.18 EFX03125.1 - 0.016 14.1 0.0 0.046 12.7 0.0 1.8 1 1 0 1 1 1 0 FAT domain APP_E2 PF12925.2 EFX03125.1 - 0.81 9.2 6.4 13 5.2 0.0 3.5 1 1 1 3 3 3 0 E2 domain of amyloid precursor protein TYW3 PF02676.9 EFX03126.1 - 3.1e-53 179.9 0.0 4.1e-53 179.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 Glyco_hydro_28 PF00295.12 EFX03127.1 - 4.9e-80 268.9 20.6 4.1e-79 265.9 14.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 EFX03127.1 - 0.0027 17.4 36.8 0.13 12.0 7.7 3.5 2 1 1 3 3 3 2 Right handed beta helix region PAN_4 PF14295.1 EFX03127.1 - 0.07 12.8 0.6 0.27 10.9 0.1 2.3 2 0 0 2 2 2 0 PAN domain adh_short_C2 PF13561.1 EFX03128.1 - 1.6e-30 106.7 0.7 2.3e-30 106.1 0.5 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX03128.1 - 6.2e-27 94.5 0.8 1.4e-26 93.4 0.6 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Lactamase_B PF00753.22 EFX03128.1 - 2.1e-23 83.0 5.2 3.8e-23 82.1 3.6 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily KR PF08659.5 EFX03128.1 - 1e-12 48.1 0.5 2.2e-12 47.0 0.1 1.7 2 0 0 2 2 2 1 KR domain Lactamase_B_2 PF12706.2 EFX03128.1 - 7.2e-06 25.6 2.9 1.3e-05 24.8 2.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EFX03128.1 - 0.00046 19.9 0.3 0.00094 18.9 0.2 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Actin PF00022.14 EFX03129.1 - 3.9e-15 55.1 0.0 3.4e-11 42.2 0.0 2.4 2 0 0 2 2 2 2 Actin Daxx PF03344.10 EFX03129.1 - 3.3 6.0 17.2 4.8 5.5 11.9 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EFX03129.1 - 7.6 4.3 20.7 12 3.7 14.3 1.2 1 0 0 1 1 1 0 Nop14-like family bZIP_1 PF00170.16 EFX03131.1 - 0.00015 21.6 5.2 0.00023 21.0 3.6 1.2 1 0 0 1 1 1 1 bZIP transcription factor Circo_capsid PF02443.10 EFX03131.1 - 0.0059 16.0 0.1 0.0089 15.4 0.1 1.3 1 0 0 1 1 1 1 Circovirus capsid protein bZIP_2 PF07716.10 EFX03131.1 - 0.19 11.5 7.1 0.27 11.0 4.9 1.2 1 0 0 1 1 1 0 Basic region leucine zipper EIF_2_alpha PF07541.7 EFX03132.1 - 4.7e-38 129.4 0.2 1.1e-37 128.2 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 EFX03132.1 - 1.4e-12 47.5 0.2 2.5e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Hemagglutinin PF00509.13 EFX03132.1 - 0.005 15.0 0.1 0.0087 14.2 0.1 1.3 1 0 0 1 1 1 1 Haemagglutinin Stathmin PF00836.14 EFX03132.1 - 0.0077 15.8 3.0 0.021 14.4 0.3 2.2 2 0 0 2 2 2 1 Stathmin family Zn_clus PF00172.13 EFX03133.1 - 3.4e-08 33.2 11.9 5.5e-08 32.5 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OmpH PF03938.9 EFX03133.1 - 0.019 14.8 49.4 0.063 13.2 22.6 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Spore_coat_CotO PF14153.1 EFX03133.1 - 0.43 9.9 25.2 3.7 6.9 0.3 2.3 2 0 0 2 2 2 0 Spore coat protein CotO AAA_23 PF13476.1 EFX03133.1 - 3.8 7.7 16.4 3.4 7.9 8.1 2.1 2 0 0 2 2 2 0 AAA domain Ycf1 PF05758.7 EFX03133.1 - 4.4 4.8 14.3 2.5 5.7 7.8 1.8 2 0 0 2 2 2 0 Ycf1 Tim54 PF11711.3 EFX03133.1 - 4.6 5.7 15.0 0.63 8.5 5.8 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 VIT1 PF01988.14 EFX03133.1 - 5.2 6.4 9.9 0.45 9.9 2.4 2.0 2 0 0 2 2 2 0 VIT family EOS1 PF12326.3 EFX03134.1 - 7.4e-14 51.6 7.1 1.8e-09 37.4 1.9 2.5 1 1 1 2 2 2 2 N-glycosylation protein Ribosomal_L22 PF00237.14 EFX03135.1 - 2.7e-10 40.1 0.0 1.2e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 Ribosomal protein L22p/L17e HAD_2 PF13419.1 EFX03137.1 - 1.6e-11 44.7 0.1 6.7e-08 32.9 0.0 2.8 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX03137.1 - 1.4e-08 34.3 0.6 3.2e-08 33.1 0.4 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 EFX03137.1 - 9.9e-07 29.1 0.0 1.6e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFX03137.1 - 2.9e-06 27.8 6.1 0.0002 21.8 0.6 3.1 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 EFX03137.1 - 0.027 13.8 0.0 1.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase AATase PF07247.7 EFX03138.1 - 0.013 14.1 0.0 0.015 13.8 0.0 1.0 1 0 0 1 1 1 0 Alcohol acetyltransferase BSD PF03909.12 EFX03140.1 - 1.7e-13 50.0 0.0 3.7e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 BSD domain Daxx PF03344.10 EFX03140.1 - 0.1 11.0 38.7 0.17 10.3 26.8 1.3 1 0 0 1 1 1 0 Daxx Family Sigma70_r2 PF04542.9 EFX03140.1 - 0.16 11.5 1.6 0.18 11.4 0.1 1.8 2 0 0 2 2 2 0 Sigma-70 region 2 Zip PF02535.17 EFX03140.1 - 0.27 10.2 5.0 0.4 9.6 3.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Lin-8 PF03353.10 EFX03140.1 - 0.94 8.6 18.6 1.5 8.0 12.9 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SAPS PF04499.10 EFX03140.1 - 3.2 6.2 17.5 4.7 5.7 12.1 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ycf1 PF05758.7 EFX03140.1 - 8.7 3.9 21.0 12 3.5 14.5 1.1 1 0 0 1 1 1 0 Ycf1 FA_hydroxylase PF04116.8 EFX03141.1 - 5.3e-16 59.0 16.8 5.3e-16 59.0 11.7 1.9 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily SBDS PF01172.13 EFX03142.1 - 5e-23 80.7 0.3 6.9e-23 80.2 0.0 1.3 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein IIGP PF05049.8 EFX03143.1 - 3.5e-23 82.0 0.0 4.3e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.18 EFX03143.1 - 1.9e-07 31.0 0.0 3.9e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 EFX03143.1 - 0.00024 21.4 0.1 0.00081 19.7 0.1 1.7 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.11 EFX03143.1 - 0.00088 18.4 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 EFX03143.1 - 0.0011 19.4 0.0 0.0034 17.8 0.0 1.9 2 0 0 2 2 1 1 Miro-like protein FeoB_N PF02421.13 EFX03143.1 - 0.0015 17.8 0.0 0.0021 17.3 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.7 EFX03143.1 - 0.0016 17.5 0.0 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 EFX03143.1 - 0.0034 17.2 1.1 0.014 15.1 0.7 2.2 1 1 0 1 1 1 1 Dynamin family AAA_29 PF13555.1 EFX03143.1 - 0.011 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 EFX03143.1 - 0.011 15.8 0.1 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX03143.1 - 0.015 15.2 0.5 0.042 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain SMC_N PF02463.14 EFX03143.1 - 0.028 13.6 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 EFX03143.1 - 0.034 14.4 1.8 0.35 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 EFX03143.1 - 0.049 13.4 1.8 0.39 10.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.1 EFX03143.1 - 0.059 14.1 3.9 0.34 11.7 2.7 2.2 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFX03143.1 - 0.059 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_21 PF13304.1 EFX03143.1 - 0.085 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EFX03143.1 - 0.12 11.9 1.3 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 EFX03143.1 - 0.15 11.5 0.2 0.5 9.8 0.1 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.1 EFX03143.1 - 0.28 11.4 4.7 1.3 9.3 3.3 2.0 1 1 0 1 1 1 0 AAA domain Glyco_hydro_47 PF01532.15 EFX03144.1 - 1.3e-130 436.0 0.0 1.5e-130 435.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 NACHT PF05729.7 EFX03145.1 - 4.1e-09 36.3 0.0 2.7e-08 33.6 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EFX03145.1 - 0.0018 18.3 0.0 0.015 15.3 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_10 PF12846.2 EFX03145.1 - 0.016 14.6 0.4 0.062 12.7 0.2 1.8 2 1 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 EFX03145.1 - 0.017 15.9 0.0 0.079 13.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EFX03145.1 - 0.027 13.6 0.0 0.062 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX03145.1 - 0.036 14.1 0.0 0.29 11.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFX03145.1 - 0.043 13.3 0.4 0.095 12.2 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX03145.1 - 0.046 14.0 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 EFX03145.1 - 0.059 12.2 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.22 EFX03145.1 - 0.1 12.9 0.1 0.32 11.2 0.1 1.8 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.12 EFX03145.1 - 0.15 11.5 0.1 0.49 9.8 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.1 EFX03145.1 - 1.1 9.5 6.1 0.15 12.3 0.4 2.1 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.1 EFX03147.1 - 0.01 15.9 0.0 0.028 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFX03147.1 - 0.019 14.3 0.1 3.7 6.9 0.1 2.7 3 1 0 3 3 3 0 AAA-like domain Transcrip_act PF04949.8 EFX03147.1 - 0.03 13.9 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 Transcriptional activator SNAP PF14938.1 EFX03147.1 - 0.039 13.1 0.0 0.08 12.0 0.0 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP AAA PF00004.24 EFX03147.1 - 0.047 13.8 0.3 0.18 12.0 0.2 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFX03147.1 - 0.094 12.6 1.6 0.87 9.5 0.2 2.7 1 1 1 2 2 2 0 AAA ATPase domain DUF3987 PF13148.1 EFX03147.1 - 0.11 11.0 0.1 0.26 9.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) MARVEL PF01284.18 EFX03148.1 - 2.5e-17 63.0 13.1 3e-17 62.7 9.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF4234 PF14018.1 EFX03148.1 - 0.033 13.9 2.1 0.092 12.5 1.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) DUF2976 PF11190.3 EFX03148.1 - 0.047 13.2 0.3 0.047 13.2 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) UbiA PF01040.13 EFX03148.1 - 1.3 8.1 15.0 2.3 7.3 10.4 1.6 1 1 0 1 1 1 0 UbiA prenyltransferase family RNA_Me_trans PF04252.8 EFX03149.1 - 1.6e-44 151.6 0.0 1.9e-44 151.4 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase WD40 PF00400.27 EFX03150.1 - 7.1e-12 44.7 0.1 1.2e-08 34.5 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF2415 PF10313.4 EFX03150.1 - 0.053 13.1 0.0 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) DUF619 PF04768.8 EFX03151.1 - 9.3e-50 168.3 0.0 5.5e-49 165.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF619) RPE65 PF03055.10 EFX03152.1 - 5.4e-105 351.7 0.0 6.9e-105 351.3 0.0 1.1 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein ArfGap PF01412.13 EFX03153.1 - 6.9e-32 109.6 0.1 1.1e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf p450 PF00067.17 EFX03155.1 - 5.6e-25 87.7 0.0 1.3e-24 86.6 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 Pkinase PF00069.20 EFX03156.1 - 1.2e-56 191.7 0.0 1.9e-56 191.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03156.1 - 5.2e-34 117.4 0.0 6.9e-33 113.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX03156.1 - 5.6e-09 35.3 0.0 1.7e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EFX03156.1 - 0.007 16.1 0.3 0.018 14.7 0.2 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 EFX03156.1 - 0.083 11.6 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FAA_hydrolase PF01557.13 EFX03158.1 - 2e-52 177.8 0.0 2.6e-52 177.4 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family ZU5 PF00791.15 EFX03158.1 - 0.034 13.8 0.0 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 ZU5 domain Dirigent PF03018.9 EFX03158.1 - 0.056 12.9 0.1 0.28 10.7 0.0 1.9 2 0 0 2 2 2 0 Dirigent-like protein SF3b1 PF08920.5 EFX03159.1 - 2.2e-35 121.8 3.5 3.5e-35 121.1 0.1 2.4 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.1 EFX03159.1 - 9.6e-16 57.8 1.6 0.01 16.1 0.0 7.6 6 3 3 9 9 9 6 HEAT repeats HEAT_EZ PF13513.1 EFX03159.1 - 5.1e-12 45.9 2.5 0.34 11.4 0.0 7.6 6 1 1 7 7 7 3 HEAT-like repeat HEAT PF02985.17 EFX03159.1 - 3.3e-11 42.2 13.6 0.084 12.9 0.1 9.9 10 0 0 10 10 10 3 HEAT repeat Vac14_Fab1_bd PF12755.2 EFX03159.1 - 7.6e-08 32.6 0.6 0.43 10.9 0.0 5.4 6 0 0 6 6 6 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 EFX03159.1 - 0.00071 18.0 0.6 0.26 9.5 0.0 3.3 2 2 0 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.2 EFX03159.1 - 0.0011 18.8 0.2 1.8 8.3 0.0 4.4 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 EFX03159.1 - 0.0015 17.9 0.5 1.3 8.3 0.0 3.8 4 1 0 4 4 4 1 CLASP N terminal NUC173 PF08161.7 EFX03159.1 - 0.0086 15.4 0.5 4.9 6.4 0.0 3.8 4 0 0 4 4 4 1 NUC173 domain 14-3-3 PF00244.15 EFX03160.1 - 3.4e-114 379.8 1.0 5.3e-114 379.1 0.7 1.3 1 0 0 1 1 1 1 14-3-3 protein DUF837 PF05769.6 EFX03160.1 - 0.0057 16.2 0.2 11 5.5 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF837) TPR_12 PF13424.1 EFX03160.1 - 0.015 15.2 0.2 6.2 6.8 0.0 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF327 PF03885.8 EFX03160.1 - 0.079 12.7 0.8 1.7 8.4 0.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF327) AATF-Che1 PF13339.1 EFX03160.1 - 1.2 9.2 6.3 6.7 6.8 0.2 3.1 3 0 0 3 3 3 0 Apoptosis antagonizing transcription factor Arteri_Gl PF00951.13 EFX03161.1 - 2.3 7.7 12.7 0.41 10.2 5.0 2.0 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein Spo7 PF03907.8 EFX03162.1 - 4.8e-63 212.5 0.0 8.8e-63 211.6 0.0 1.4 1 1 0 1 1 1 1 Spo7-like protein Zip PF02535.17 EFX03162.1 - 0.23 10.4 3.3 0.43 9.5 2.3 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter HABP4_PAI-RBP1 PF04774.10 EFX03163.1 - 0.0027 18.1 2.7 0.004 17.6 1.9 1.4 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family HD-ZIP_N PF04618.7 EFX03163.1 - 0.076 13.5 0.3 0.11 13.0 0.2 1.3 1 0 0 1 1 1 0 HD-ZIP protein N terminus ELMO_CED12 PF04727.8 EFX03164.1 - 1.3e-48 164.7 0.0 2.3e-48 163.9 0.0 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.3 EFX03164.1 - 0.00041 20.0 0.0 0.024 14.3 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3361) Pkinase PF00069.20 EFX03165.1 - 3.2e-10 39.6 0.0 3.9e-08 32.7 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03165.1 - 9.9e-08 31.3 0.0 7.1e-06 25.2 0.0 3.0 2 1 0 2 2 2 1 Protein tyrosine kinase KH_1 PF00013.24 EFX03166.1 - 1.7e-21 75.5 6.2 2.1e-07 30.5 0.5 6.1 7 0 0 7 7 7 4 KH domain KH_3 PF13014.1 EFX03166.1 - 1.2e-19 69.5 8.6 0.00019 20.9 0.6 5.7 5 0 0 5 5 5 5 KH domain DUF1479 PF07350.7 EFX03166.1 - 0.008 14.7 0.0 0.014 13.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Ribosomal_L36e PF01158.13 EFX03167.1 - 7.8e-41 138.0 3.7 8.8e-41 137.8 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e LemA PF04011.7 EFX03167.1 - 0.015 14.3 0.0 0.017 14.2 0.0 1.0 1 0 0 1 1 1 0 LemA family eIF-1a PF01176.14 EFX03168.1 - 4.9e-22 77.1 0.1 7.1e-22 76.6 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RNA_pol_Rpb5_C PF01191.14 EFX03169.1 - 2.7e-35 119.7 0.3 4.4e-35 119.1 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 EFX03169.1 - 2.8e-29 101.3 0.0 4.8e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.7 EFX03169.1 - 0.0038 17.0 0.0 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 Restriction endonuclease ATP-synt_C PF00137.16 EFX03170.1 - 2.9e-25 87.9 23.3 1.7e-16 59.8 6.0 3.1 3 1 0 3 3 3 2 ATP synthase subunit C Oxidored_q2 PF00420.19 EFX03170.1 - 9.3 5.9 8.3 8.3 6.0 2.7 2.8 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L RRM_1 PF00076.17 EFX03171.1 - 3.7e-30 103.3 0.1 7.8e-14 51.0 0.0 3.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03171.1 - 6.3e-25 86.9 0.0 5.6e-12 45.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03171.1 - 4e-09 36.1 0.0 0.0034 17.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.10 EFX03171.1 - 0.018 14.7 0.1 16 5.2 0.0 3.2 3 0 0 3 3 3 0 DbpA RNA binding domain TPT PF03151.11 EFX03172.1 - 1.9e-16 60.0 13.5 1.9e-16 60.0 9.4 2.3 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 EFX03172.1 - 0.00019 21.4 14.2 0.00019 21.4 9.9 2.8 2 1 1 3 3 3 1 EamA-like transporter family EmrE PF13536.1 EFX03172.1 - 7.2 6.8 31.2 0.63 10.2 4.7 3.1 2 1 1 3 3 3 0 Multidrug resistance efflux transporter Kelch_5 PF13854.1 EFX03173.1 - 5.7e-14 51.7 3.9 5.8e-12 45.2 0.5 4.5 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.1 EFX03173.1 - 3.3e-06 27.1 10.3 9e-05 22.5 0.4 6.0 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_1 PF01344.20 EFX03173.1 - 0.00013 21.4 1.1 0.77 9.3 0.2 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 EFX03173.1 - 0.0012 18.9 1.6 0.0065 16.5 0.1 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 EFX03173.1 - 0.017 14.8 0.3 0.017 14.8 0.2 4.4 6 0 0 6 6 6 0 Galactose oxidase, central domain tRNA-synt_2b PF00587.20 EFX03175.1 - 1.1e-43 148.8 0.2 1.9e-43 148.0 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFX03175.1 - 2.1e-16 59.6 0.2 4e-16 58.7 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.16 EFX03175.1 - 6.1e-13 48.4 0.0 1.3e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.9 EFX03175.1 - 2e-11 43.5 0.0 4.1e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain zf-RanBP PF00641.13 EFX03176.1 - 3.9e-18 64.2 14.2 7.1e-11 41.0 1.1 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 EFX03176.1 - 9.1e-09 34.8 0.0 2e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.19 EFX03176.1 - 2.2e-06 28.0 0.0 3.6e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Exonuclease RRM_6 PF14259.1 EFX03176.1 - 8.7e-06 25.6 0.0 1.7e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 EFX03176.1 - 2.8 7.8 10.6 0.8 9.5 0.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon Ras PF00071.17 EFX03177.1 - 8.2e-31 106.5 1.7 2.9e-20 72.2 0.1 2.1 1 1 1 2 2 2 2 Ras family Miro PF08477.8 EFX03177.1 - 2.9e-11 43.9 0.9 0.00014 22.3 0.1 2.5 2 1 1 3 3 3 2 Miro-like protein Arf PF00025.16 EFX03177.1 - 0.002 17.4 0.7 0.039 13.1 0.1 2.1 1 1 0 2 2 2 1 ADP-ribosylation factor family RNA_helicase PF00910.17 EFX03177.1 - 0.002 18.2 0.1 0.0049 17.0 0.0 1.7 1 1 0 1 1 1 1 RNA helicase Pox_A32 PF04665.7 EFX03177.1 - 0.02 14.1 0.1 0.04 13.2 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.15 EFX03177.1 - 0.026 13.2 0.7 0.66 8.5 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit AAA_22 PF13401.1 EFX03177.1 - 0.037 14.1 0.1 0.14 12.3 0.1 1.9 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 EFX03177.1 - 0.068 13.0 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EFX03177.1 - 0.15 11.7 0.1 0.32 10.6 0.1 1.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MFS_1 PF07690.11 EFX03178.1 - 1.5e-27 96.2 43.1 2.4e-25 89.0 14.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX03178.1 - 3.1e-11 42.5 13.1 3.1e-11 42.5 9.0 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter ATP11 PF06644.6 EFX03179.1 - 5.3e-77 258.9 0.0 6.6e-77 258.6 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Gag_spuma PF03276.9 EFX03179.1 - 0.036 12.3 2.8 0.053 11.8 1.9 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Sporozoite_P67 PF05642.6 EFX03179.1 - 1.4 6.6 7.0 1.8 6.2 4.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen WD40 PF00400.27 EFX03180.1 - 8.2e-32 107.9 4.2 2.9e-09 36.4 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat PQQ_3 PF13570.1 EFX03180.1 - 1 9.7 4.7 4.6 7.6 0.3 3.6 4 0 0 4 4 4 0 PQQ-like domain Peptidase_S49_N PF08496.5 EFX03180.1 - 1.2 8.9 3.6 0.26 11.0 0.1 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Topoisom_I_N PF02919.10 EFX03181.1 - 4.5e-94 313.7 1.5 4.5e-94 313.7 1.1 1.9 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 EFX03181.1 - 1e-84 283.3 4.4 1e-84 283.3 3.0 2.2 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 EFX03181.1 - 1.8e-31 107.5 0.1 5e-31 106.1 0.1 1.8 1 0 0 1 1 1 1 C-terminal topoisomerase domain CTDII PF01556.13 EFX03182.1 - 3.3e-18 65.3 0.1 4e-16 58.6 0.0 3.0 3 0 0 3 3 3 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EFX03182.1 - 9.7e-15 54.3 15.8 1.7e-14 53.6 11.0 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.26 EFX03182.1 - 1.7e-11 43.6 0.7 3.9e-11 42.5 0.5 1.6 1 0 0 1 1 1 1 DnaJ domain HypA PF01155.14 EFX03182.1 - 0.0023 17.6 7.5 0.38 10.4 0.6 2.4 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family Cytochrom_c3_2 PF14537.1 EFX03182.1 - 0.17 12.2 6.6 0.35 11.2 4.6 1.6 1 0 0 1 1 1 0 Cytochrome c3 DUF1356 PF07092.7 EFX03182.1 - 1.1 8.3 3.7 1.6 7.9 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) Ras PF00071.17 EFX03183.1 - 1.4e-40 138.3 0.0 2.2e-38 131.2 0.0 2.1 2 0 0 2 2 2 1 Ras family Miro PF08477.8 EFX03183.1 - 9.3e-19 68.0 0.0 1.3e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX03183.1 - 9.9e-10 37.9 0.0 1.5e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFX03183.1 - 0.0015 18.4 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 EFX03183.1 - 0.0021 17.2 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 EFX03183.1 - 0.022 13.9 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EFX03183.1 - 0.043 13.3 0.0 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.1 EFX03183.1 - 0.072 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX03183.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.18 EFX03183.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Dynamin family AAA_17 PF13207.1 EFX03183.1 - 0.11 13.3 0.0 0.19 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFX03183.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFX03183.1 - 0.12 12.3 0.4 0.53 10.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.11 EFX03183.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 EFX03183.1 - 0.14 11.7 0.1 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFX03183.1 - 0.17 11.6 0.3 0.35 10.5 0.2 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 EFX03183.1 - 0.19 11.4 0.1 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SF3b10 PF07189.6 EFX03184.1 - 2.2e-33 113.9 0.0 2.6e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) TAP_C PF03943.8 EFX03185.1 - 1.3e-11 43.7 0.3 2.7e-11 42.7 0.2 1.6 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.15 EFX03185.1 - 2.6e-08 34.2 0.0 7.2e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.2 EFX03185.1 - 3.4e-07 29.7 3.2 8.1e-05 22.1 0.1 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) UBA_4 PF14555.1 EFX03185.1 - 0.012 15.1 0.8 0.024 14.1 0.1 1.9 2 0 0 2 2 2 0 UBA-like domain LRR_8 PF13855.1 EFX03185.1 - 0.015 15.0 0.3 0.04 13.6 0.2 1.7 1 0 0 1 1 1 0 Leucine rich repeat LRR_1 PF00560.28 EFX03185.1 - 0.023 14.6 1.8 0.93 9.7 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.1 EFX03185.1 - 0.14 12.2 0.9 5.9 7.2 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat Med1 PF10744.4 EFX03186.1 - 2.4e-38 131.9 0.0 5.6e-26 91.2 0.0 2.1 2 0 0 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 YEATS PF03366.11 EFX03187.1 - 4.5e-25 87.1 0.1 8.2e-25 86.3 0.1 1.5 1 0 0 1 1 1 1 YEATS family Baculo_8kDa PF06096.6 EFX03187.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein ATG2_CAD PF13329.1 EFX03188.1 - 1.4e-41 141.7 0.0 3.5e-41 140.4 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 EFX03188.1 - 5.6e-31 106.6 0.1 4.7e-30 103.6 0.1 2.6 3 0 0 3 3 3 1 ATG C terminal domain Sec62 PF03839.11 EFX03189.1 - 7.5e-53 179.2 0.0 1.1e-52 178.7 0.0 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 Ran_BP1 PF00638.13 EFX03190.1 - 1.6e-49 166.9 0.5 1.6e-49 166.9 0.3 1.5 2 0 0 2 2 2 1 RanBP1 domain PS-DH PF14765.1 EFX03190.1 - 0.0063 15.7 1.1 0.0085 15.2 0.2 1.5 2 0 0 2 2 2 1 Polyketide synthase dehydratase WH1 PF00568.18 EFX03190.1 - 0.041 13.5 0.0 0.13 11.9 0.0 1.8 1 1 0 1 1 1 0 WH1 domain USP8_dimer PF08969.6 EFX03190.1 - 0.16 11.9 2.3 0.38 10.7 1.0 2.0 1 1 1 2 2 2 0 USP8 dimerisation domain DUF4611 PF15387.1 EFX03190.1 - 3 8.0 7.8 1.5 9.0 1.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4611) Amino_oxidase PF01593.19 EFX03191.1 - 5.3e-18 65.3 0.0 6.5e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFX03191.1 - 2.7e-15 56.1 0.1 4.4e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFX03191.1 - 0.00019 21.8 0.1 0.00032 21.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX03191.1 - 0.00022 20.2 1.1 0.00027 19.9 0.8 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX03191.1 - 0.00068 18.5 0.1 0.00098 18.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 EFX03191.1 - 0.00092 19.3 0.2 0.0015 18.6 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFX03191.1 - 0.0014 17.8 0.5 0.0021 17.1 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EFX03191.1 - 0.002 16.6 0.0 0.0028 16.2 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 EFX03191.1 - 0.0026 17.6 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX03191.1 - 0.0037 16.4 0.0 0.0071 15.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family 3HCDH_N PF02737.13 EFX03191.1 - 0.013 15.2 0.1 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF4574 PF15141.1 EFX03191.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4574) NAD_binding_9 PF13454.1 EFX03191.1 - 0.15 11.8 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding GIDA PF01134.17 EFX03191.1 - 0.18 10.6 0.1 0.25 10.1 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FUSC_2 PF13515.1 EFX03192.1 - 4.7e-23 81.5 4.9 4.7e-23 81.5 3.4 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like SCF PF02404.10 EFX03192.1 - 0.051 12.7 0.2 0.11 11.6 0.1 1.5 1 0 0 1 1 1 0 Stem cell factor DUF2422 PF10337.4 EFX03192.1 - 0.15 10.8 11.4 0.31 9.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2422) DHquinase_I PF01487.10 EFX03193.1 - 2.2e-41 141.9 0.0 2.8e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Type I 3-dehydroquinase Phage_antitermQ PF06530.7 EFX03193.1 - 0.0046 16.5 0.0 0.0088 15.6 0.0 1.4 1 0 0 1 1 1 1 Phage antitermination protein Q Pyridoxal_deC PF00282.14 EFX03194.1 - 6.7e-21 74.1 0.0 9.5e-21 73.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain SLA_LP_auto_ag PF05889.8 EFX03194.1 - 0.019 13.4 0.0 0.032 12.7 0.0 1.3 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) 3-HAO PF06052.7 EFX03195.1 - 4.4e-62 207.9 0.0 5e-62 207.7 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 EFX03195.1 - 7.2e-07 28.6 0.0 1.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 EFX03195.1 - 0.00012 21.5 0.0 0.00017 21.0 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.9 EFX03195.1 - 0.00065 19.6 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 ARD/ARD' family DZR PF12773.2 EFX03195.1 - 0.0058 16.4 0.4 0.013 15.2 0.3 1.6 1 0 0 1 1 1 1 Double zinc ribbon AraC_binding PF02311.14 EFX03195.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain Cupin_4 PF08007.7 EFX03195.1 - 0.083 12.1 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein AdoMet_MTase PF07757.8 EFX03196.1 - 7.7e-36 122.6 0.3 2.7e-35 120.8 0.2 1.8 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_23 PF13489.1 EFX03196.1 - 0.0017 18.0 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EFX03196.1 - 0.037 13.7 0.1 0.12 12.0 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EFX03196.1 - 0.1 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain MFS_1 PF07690.11 EFX03197.1 - 3e-29 101.8 31.0 4.3e-29 101.3 21.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2562 PF10814.3 EFX03199.1 - 0.021 14.7 0.3 0.051 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2562) Amidohydro_3 PF07969.6 EFX03200.1 - 6.4e-58 196.8 0.1 9.3e-58 196.3 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase family SPX PF03105.14 EFX03200.1 - 9.7e-15 55.0 4.9 5.4e-08 32.9 0.1 2.8 2 1 1 3 3 3 2 SPX domain Amidohydro_5 PF13594.1 EFX03200.1 - 0.0095 15.7 0.0 0.029 14.1 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EFX03200.1 - 0.057 13.0 0.0 1.8 8.1 0.0 2.4 2 0 0 2 2 2 0 Amidohydrolase family Zeta_toxin PF06414.7 EFX03201.1 - 2.9e-32 111.4 0.0 4.5e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 EFX03201.1 - 1.8e-06 27.8 0.0 3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX03201.1 - 0.0058 16.6 0.5 0.027 14.4 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.12 EFX03201.1 - 0.017 14.9 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 SRP54 PF00448.17 EFX03201.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.1 EFX03201.1 - 0.051 14.3 0.0 0.17 12.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF4449 PF14613.1 EFX03202.1 - 3.3e-67 225.5 0.4 8.3e-67 224.2 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) PPR_2 PF13041.1 EFX03203.1 - 4.6e-23 80.9 0.5 3.7e-15 55.6 0.0 3.5 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.1 EFX03203.1 - 4.8e-06 26.4 0.8 0.68 10.3 0.0 5.1 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.15 EFX03203.1 - 1e-05 25.1 2.8 0.00011 21.9 0.1 3.7 4 0 0 4 4 4 1 PPR repeat PPR_1 PF12854.2 EFX03203.1 - 5.1e-05 22.6 1.5 0.0011 18.4 0.0 3.2 3 0 0 3 3 3 1 PPR repeat CUE PF02845.11 EFX03203.1 - 0.0012 18.2 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 CUE domain RRM_1 PF00076.17 EFX03203.1 - 0.0034 16.9 0.0 0.007 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03203.1 - 0.0083 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03203.1 - 0.022 14.7 0.0 0.052 13.5 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Flavin_Reduct PF01613.13 EFX03204.1 - 3.5e-18 65.9 0.0 6.3e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Flavin reductase like domain P5CR_dimer PF14748.1 EFX03205.1 - 3.4e-33 113.8 1.0 1.1e-32 112.2 0.7 1.9 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 EFX03205.1 - 2.7e-09 37.3 7.4 3.1e-08 33.9 0.1 3.6 4 0 0 4 4 4 1 NADP oxidoreductase coenzyme F420-dependent Rifin_STEVOR PF02009.11 EFX03205.1 - 0.00043 20.0 0.0 0.00075 19.2 0.0 1.3 1 0 0 1 1 1 1 Rifin/stevor family Adeno_E3_CR2 PF02439.10 EFX03205.1 - 0.0013 18.2 0.1 0.019 14.5 0.0 2.4 2 0 0 2 2 2 1 Adenovirus E3 region protein CR2 Kelch_6 PF13964.1 EFX03205.1 - 0.0034 17.5 8.2 3 8.1 0.1 4.5 5 0 0 5 5 4 2 Kelch motif SKG6 PF08693.5 EFX03205.1 - 0.0039 16.4 0.4 0.012 14.9 0.3 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.1 EFX03205.1 - 0.007 16.0 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family DUF912 PF06024.7 EFX03205.1 - 0.0093 16.0 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 EFX03205.1 - 0.12 10.5 0.4 0.22 9.7 0.2 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Syndecan PF01034.15 EFX03205.1 - 0.12 12.0 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.1 EFX03205.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain WD40 PF00400.27 EFX03206.1 - 3.5e-59 194.7 27.7 4.5e-11 42.1 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EFX03206.1 - 0.0002 19.6 6.1 0.24 9.4 0.1 4.1 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 EFX03206.1 - 0.032 12.5 0.0 4.3 5.5 0.1 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain ALAD PF00490.16 EFX03207.1 - 5.3e-118 393.6 0.0 7.8e-118 393.0 0.0 1.2 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase adh_short PF00106.20 EFX03208.1 - 2.4e-26 92.6 0.1 3.4e-26 92.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX03208.1 - 2.1e-24 86.5 0.0 2.6e-24 86.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX03208.1 - 1.3e-11 44.4 0.0 2.2e-11 43.7 0.0 1.4 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.5 EFX03208.1 - 0.014 14.5 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 EFX03208.1 - 0.042 13.2 0.1 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Pkinase PF00069.20 EFX03209.1 - 4.2e-13 49.0 0.2 1.7e-10 40.5 0.0 2.9 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03209.1 - 4.9e-13 48.7 0.0 6.5e-12 45.0 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Mannosyl_trans3 PF11051.3 EFX03209.1 - 0.078 12.3 0.4 0.15 11.4 0.3 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative Seadorna_VP7 PF07387.6 EFX03209.1 - 0.18 10.5 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Fis1_TPR_C PF14853.1 EFX03210.1 - 2e-25 88.3 1.5 3.1e-25 87.7 1.1 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 EFX03210.1 - 1.9e-17 62.2 0.0 3.2e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.12 EFX03210.1 - 0.00085 19.0 1.6 0.0016 18.1 1.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX03210.1 - 0.0073 16.9 0.1 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 EFX03210.1 - 0.051 14.0 0.5 0.16 12.4 0.2 2.0 3 0 0 3 3 3 0 Tetratricopeptide repeat GTP_EFTU PF00009.22 EFX03211.1 - 3.5e-57 192.9 0.0 5.3e-57 192.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EFX03211.1 - 6.1e-36 122.5 0.1 1.9e-35 120.9 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EFX03211.1 - 3.1e-17 62.4 1.8 3.1e-17 62.4 1.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 EFX03211.1 - 4.6e-05 22.9 0.5 0.00012 21.6 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 EFX03211.1 - 0.00069 19.5 0.2 0.0021 18.0 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase His_Phos_2 PF00328.17 EFX03212.1 - 2.4e-19 69.8 0.0 2.2e-11 43.6 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) MFS_1 PF07690.11 EFX03213.1 - 3.2e-29 101.7 64.6 2.1e-28 99.0 42.2 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily RhoGAP PF00620.22 EFX03214.1 - 5.1e-38 130.0 0.0 8.1e-38 129.4 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF2373 PF10180.4 EFX03215.1 - 2.6e-17 62.0 0.4 4.3e-17 61.4 0.3 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Prenyltrans PF00432.16 EFX03216.1 - 4.5e-06 26.1 5.4 1.5e-05 24.4 3.7 1.9 1 1 0 1 1 1 1 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EFX03216.1 - 2.5e-05 24.6 0.1 2.6e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 Prenyltransferase-like Prenyltrans_1 PF13243.1 EFX03216.1 - 0.00011 22.1 0.0 0.00013 21.9 0.0 1.1 1 0 0 1 1 1 1 Prenyltransferase-like ABC2_membrane PF01061.19 EFX03218.1 - 7.7e-74 247.3 65.7 7.9e-45 152.5 15.3 4.5 4 1 1 5 5 5 3 ABC-2 type transporter PDR_CDR PF06422.7 EFX03218.1 - 6.7e-34 115.6 5.5 2.3e-27 94.6 0.1 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 EFX03218.1 - 1.3e-32 113.0 0.1 5.6e-18 65.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.1 EFX03218.1 - 5.8e-17 61.5 0.0 1.4e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 EFX03218.1 - 8.6e-07 28.5 0.4 0.00082 18.8 0.0 3.0 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EFX03218.1 - 1e-05 24.8 0.2 0.002 17.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 EFX03218.1 - 1.2e-05 24.7 1.2 0.0014 18.1 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EFX03218.1 - 1.6e-05 24.9 1.7 0.0016 18.4 0.1 2.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 EFX03218.1 - 8.2e-05 22.5 0.1 0.0063 16.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX03218.1 - 0.00054 20.0 0.4 0.16 12.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.1 EFX03218.1 - 0.0029 18.4 0.0 0.057 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 EFX03218.1 - 0.003 16.8 0.0 1.9 7.6 0.0 3.1 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 EFX03218.1 - 0.0039 17.4 0.1 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EFX03218.1 - 0.0064 16.4 0.2 5.6 6.9 0.0 3.0 3 0 0 3 3 2 1 50S ribosome-binding GTPase cobW PF02492.14 EFX03218.1 - 0.0091 15.4 4.3 0.12 11.8 0.4 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 EFX03218.1 - 0.015 14.9 2.4 1.1 8.8 0.1 2.7 2 0 0 2 2 2 0 NACHT domain AAA_21 PF13304.1 EFX03218.1 - 0.026 14.5 0.0 0.32 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.2 EFX03218.1 - 0.048 12.6 54.7 0.11 11.5 18.3 3.8 2 2 0 2 2 2 0 ABC-2 family transporter protein AAA_23 PF13476.1 EFX03218.1 - 0.059 13.6 0.7 0.17 12.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EFX03218.1 - 0.077 12.4 1.8 4.9 6.5 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain AAA PF00004.24 EFX03218.1 - 0.079 13.1 0.1 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFX03218.1 - 0.083 12.6 2.1 8.6 6.1 0.2 2.8 2 0 0 2 2 2 0 Part of AAA domain AAA_28 PF13521.1 EFX03218.1 - 0.084 12.8 0.1 0.084 12.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.13 EFX03218.1 - 0.14 11.6 0.2 5.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 EFX03218.1 - 0.22 11.1 1.6 0.68 9.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 DUF2945 PF11160.3 EFX03219.1 - 0.034 13.9 0.1 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2945) Methyltransf_23 PF13489.1 EFX03220.1 - 5.7e-12 45.6 0.0 9.5e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03220.1 - 0.00046 20.5 0.0 0.0047 17.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03220.1 - 0.005 16.4 0.0 3 7.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03220.1 - 0.047 14.2 0.1 1.1 9.8 0.0 2.6 1 1 0 1 1 1 0 Methyltransferase domain EMP70 PF02990.11 EFX03222.1 - 5.7e-157 523.3 17.4 4.2e-104 348.8 15.9 2.7 2 1 0 2 2 2 2 Endomembrane protein 70 DUF3267 PF11667.3 EFX03222.1 - 0.02 15.0 8.9 0.94 9.7 0.8 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3267) DUF3169 PF11368.3 EFX03222.1 - 3.1 6.9 11.8 0.97 8.5 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) DNA_ligase_A_M PF01068.16 EFX03223.1 - 1.2e-56 191.2 0.0 2.2e-56 190.4 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EFX03223.1 - 2e-52 177.5 0.8 3.6e-52 176.7 0.1 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EFX03223.1 - 3.8e-26 91.3 0.0 2.1e-25 88.9 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region MatE PF01554.13 EFX03224.1 - 4.7e-49 166.1 19.7 2.6e-27 95.4 2.3 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 EFX03224.1 - 1.3e-05 25.0 5.4 1.3e-05 25.0 3.7 4.2 3 1 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain DUF3753 PF12575.3 EFX03224.1 - 0.11 12.3 0.1 0.4 10.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Dabb PF07876.7 EFX03226.1 - 7.4e-26 90.4 0.1 8.4e-26 90.2 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Ras PF00071.17 EFX03227.1 - 3e-52 176.2 0.0 3.6e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX03227.1 - 4.3e-16 59.4 0.0 1.2e-15 58.0 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EFX03227.1 - 3.2e-06 26.5 0.0 4.4e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SnoaL_2 PF12680.2 EFX03228.1 - 2.6e-05 24.5 0.0 3.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.1 EFX03228.1 - 0.0042 16.9 0.0 0.0063 16.4 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain ATP-synt PF00231.14 EFX03229.1 - 7.7e-73 245.3 1.6 8.8e-73 245.1 1.1 1.0 1 0 0 1 1 1 1 ATP synthase ATC_hydrolase PF14196.1 EFX03229.1 - 0.11 12.8 0.0 2.9 8.3 0.0 2.5 2 2 0 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase Methyltransf_3 PF01596.12 EFX03230.1 - 2.8e-34 117.9 0.0 4.9e-34 117.1 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 EFX03230.1 - 1e-11 45.6 0.0 3.8e-11 43.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 EFX03230.1 - 1.7e-09 37.5 0.0 3.2e-09 36.6 0.0 1.4 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 EFX03230.1 - 1.9e-07 30.7 0.0 2.8e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX03230.1 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX03230.1 - 0.066 12.2 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase UTP15_C PF09384.5 EFX03231.1 - 1.6e-41 141.4 0.0 3.2e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 EFX03231.1 - 2.3e-22 78.0 6.3 3.3e-07 29.9 0.1 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat Alpha_GJ PF03229.8 EFX03232.1 - 1 9.7 8.3 0.44 10.9 3.9 1.8 1 1 1 2 2 2 0 Alphavirus glycoprotein J Pacs-1 PF10254.4 EFX03232.1 - 2.9 6.4 9.5 3.7 6.0 6.6 1.1 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Proteasome PF00227.21 EFX03233.1 - 9.1e-42 142.4 0.0 1.1e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit CFEM PF05730.6 EFX03234.1 - 7.3e-12 44.9 6.5 1.4e-11 44.0 4.5 1.5 1 0 0 1 1 1 1 CFEM domain Rax2 PF12768.2 EFX03234.1 - 0.061 12.5 0.1 0.084 12.0 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1517 PF07466.6 EFX03234.1 - 0.34 9.8 6.6 0.59 9.0 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) DUF533 PF04391.7 EFX03234.1 - 0.52 9.6 3.6 1.6 8.1 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF533) SOG2 PF10428.4 EFX03234.1 - 4.4 5.8 15.8 7.1 5.1 10.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Fungal_trans_2 PF11951.3 EFX03235.1 - 0.0044 15.6 0.2 0.0068 15.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain YABBY PF04690.8 EFX03235.1 - 0.044 14.0 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 YABBY protein OPA3 PF07047.7 EFX03236.1 - 6.9e-33 113.2 4.3 2.9e-32 111.2 3.0 2.1 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF4551 PF15087.1 EFX03236.1 - 0.039 12.3 1.3 0.054 11.8 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Nipped-B_C PF12830.2 EFX03237.1 - 7.1e-40 136.6 0.9 1.7e-39 135.4 0.1 2.2 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 EFX03237.1 - 1.9e-08 34.0 0.8 1.5e-06 28.0 0.2 3.1 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.17 EFX03237.1 - 0.0016 18.3 1.1 33 4.9 0.0 5.0 4 0 0 4 4 4 0 HEAT repeat Cnd1 PF12717.2 EFX03237.1 - 0.016 15.0 0.1 0.82 9.4 0.0 3.4 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 EFX03237.1 - 0.022 13.0 0.2 0.12 10.6 0.0 2.2 3 0 0 3 3 3 0 Adaptin N terminal region MFS_1 PF07690.11 EFX03238.1 - 7.9e-20 70.8 6.6 7.9e-20 70.8 4.6 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily Folate_carrier PF01770.13 EFX03238.1 - 0.02 13.4 0.0 0.54 8.7 0.1 2.3 1 1 1 2 2 2 0 Reduced folate carrier MFS_1 PF07690.11 EFX03240.1 - 6.7e-35 120.4 50.0 4.3e-34 117.7 34.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily adh_short PF00106.20 EFX03240.1 - 2.7e-19 69.7 3.7 4.9e-19 68.8 2.6 1.4 1 0 0 1 1 1 1 short chain dehydrogenase TRI12 PF06609.8 EFX03240.1 - 2e-13 49.4 27.0 2.9e-13 48.9 18.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) KR PF08659.5 EFX03240.1 - 6.4e-11 42.2 0.8 1.4e-10 41.1 0.6 1.5 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EFX03240.1 - 2.6e-05 23.2 0.2 4.3e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EFX03240.1 - 0.0015 18.0 0.7 0.0031 16.9 0.5 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF4169 PF13770.1 EFX03240.1 - 0.013 15.3 3.3 0.026 14.4 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) Pkinase PF00069.20 EFX03242.1 - 5e-63 212.6 0.0 5.9e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03242.1 - 1.6e-26 92.9 0.0 2e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX03242.1 - 0.0024 16.8 0.0 0.0039 16.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX03242.1 - 0.0081 15.2 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EFX03242.1 - 0.035 13.4 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family HALZ PF02183.13 EFX03242.1 - 0.041 13.5 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper APH PF01636.18 EFX03242.1 - 0.12 12.1 0.3 0.58 9.8 0.0 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family ETF PF01012.16 EFX03243.1 - 1.1e-32 113.0 1.4 1.6e-32 112.5 1.0 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain SET PF00856.23 EFX03245.1 - 0.0096 16.2 0.0 0.037 14.3 0.0 2.1 1 1 0 1 1 1 1 SET domain HTH_Tnp_Tc5 PF03221.11 EFX03246.1 - 8e-14 51.2 0.7 0.0022 17.7 0.0 6.4 5 2 1 6 6 6 3 Tc5 transposase DNA-binding domain Homeobox_KN PF05920.6 EFX03246.1 - 3.7e-13 48.9 0.5 1.1e-12 47.3 0.3 1.9 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 EFX03246.1 - 9e-05 22.0 0.1 0.00023 20.7 0.1 1.7 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_4 PF13894.1 EFX03246.1 - 0.00013 22.0 17.9 0.013 15.7 2.6 4.9 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX03246.1 - 0.0016 18.6 21.4 0.013 15.8 2.6 4.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type Zn_clus PF00172.13 EFX03246.1 - 5.1 7.0 8.0 18 5.3 5.6 2.0 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Sedlin_N PF04628.8 EFX03247.1 - 2e-40 137.7 0.0 2.3e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 EFX03247.1 - 0.021 14.5 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Sybindin-like family Cloacin_immun PF03513.9 EFX03247.1 - 0.045 13.7 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Cloacin immunity protein Lon_C PF05362.8 EFX03248.1 - 1.1e-63 214.3 0.0 1.9e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 EFX03248.1 - 7.1e-35 120.5 0.0 1.9e-34 119.1 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 EFX03248.1 - 4.7e-22 78.6 0.0 1.7e-21 76.8 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.1 EFX03248.1 - 1.5e-07 30.9 0.0 3.9e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 EFX03248.1 - 4.7e-07 29.6 0.0 1.1e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFX03248.1 - 9.8e-07 28.8 0.0 3e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EFX03248.1 - 1.8e-05 24.9 0.0 0.00041 20.4 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.6 EFX03248.1 - 8.5e-05 21.4 0.0 0.00017 20.4 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.7 EFX03248.1 - 9.6e-05 21.5 0.0 0.0013 17.8 0.0 2.6 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EFX03248.1 - 0.00011 22.9 0.0 0.00044 21.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX03248.1 - 0.00018 21.5 0.8 0.0045 17.0 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 EFX03248.1 - 0.0051 16.7 0.0 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX03248.1 - 0.0086 16.3 0.0 0.029 14.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EFX03248.1 - 0.026 13.9 0.1 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein TIP49 PF06068.8 EFX03248.1 - 0.028 13.1 0.1 1.1 7.8 0.0 2.4 2 0 0 2 2 2 0 TIP49 C-terminus MobB PF03205.9 EFX03248.1 - 0.029 14.0 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SKI PF01202.17 EFX03248.1 - 0.033 14.0 0.0 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase RNA_helicase PF00910.17 EFX03248.1 - 0.04 14.1 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DUF258 PF03193.11 EFX03248.1 - 0.046 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NTPase_1 PF03266.10 EFX03248.1 - 0.056 13.1 0.2 1.1 8.9 0.0 2.6 1 1 1 2 2 2 0 NTPase ClpB_D2-small PF10431.4 EFX03248.1 - 0.061 13.2 0.2 0.061 13.2 0.1 2.3 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein AAA_25 PF13481.1 EFX03248.1 - 0.064 12.6 0.0 0.2 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EFX03248.1 - 0.075 13.3 0.6 0.76 10.0 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Fungal_trans PF04082.13 EFX03249.1 - 1.2e-12 47.2 0.0 2.2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03249.1 - 4.1e-06 26.5 11.7 8e-06 25.6 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Histone PF00125.19 EFX03250.1 - 1e-14 54.3 0.1 1.2e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 EFX03250.1 - 0.00014 21.7 0.1 0.00021 21.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 EFX03250.1 - 0.00015 21.8 0.1 0.0002 21.4 0.0 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EFX03250.1 - 0.0005 20.0 0.1 0.00094 19.1 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EFX03250.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.3 1 1 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 EFX03250.1 - 0.036 13.3 0.0 0.036 13.3 0.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T zf-RING_2 PF13639.1 EFX03251.1 - 3.2e-10 39.6 3.6 4.9e-10 39.0 2.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-Apc11 PF12861.2 EFX03251.1 - 2.1e-05 24.2 0.3 3.4e-05 23.6 0.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EFX03251.1 - 6e-05 23.0 1.0 0.00013 22.0 0.7 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EFX03251.1 - 0.00034 20.2 1.1 0.00054 19.5 0.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.9 EFX03251.1 - 0.0014 18.0 1.3 0.041 13.3 0.1 2.4 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C3HC4_2 PF13923.1 EFX03251.1 - 0.0019 18.2 2.9 0.0031 17.5 2.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX03251.1 - 0.0055 16.3 1.2 0.0094 15.5 0.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX03251.1 - 0.044 13.5 0.8 0.074 12.8 0.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.1 EFX03251.1 - 0.046 13.3 2.0 0.12 11.9 1.5 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.1 EFX03251.1 - 0.047 13.4 3.0 0.15 11.8 0.6 2.2 1 1 1 2 2 2 0 Zinc-binding RING-finger Prok-RING_1 PF14446.1 EFX03251.1 - 3 7.6 5.3 6.1 6.6 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PPR_2 PF13041.1 EFX03252.1 - 1.3e-19 69.8 0.0 7.3e-07 29.0 0.0 6.9 5 3 2 7 7 7 4 PPR repeat family PPR_3 PF13812.1 EFX03252.1 - 2.5e-13 49.1 5.6 0.72 10.2 0.1 9.3 9 1 1 10 10 10 3 Pentatricopeptide repeat domain PPR PF01535.15 EFX03252.1 - 6.2e-12 44.6 0.1 0.36 10.9 0.0 7.2 7 0 0 7 7 7 3 PPR repeat PPR_1 PF12854.2 EFX03252.1 - 0.0002 20.7 0.0 0.032 13.6 0.0 4.1 4 0 0 4 4 4 1 PPR repeat FGGY_C PF02782.11 EFX03253.1 - 1.5e-72 243.3 1.3 3.9e-72 242.0 0.7 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFX03253.1 - 2.4e-63 213.7 0.0 3.2e-63 213.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Cu-oxidase_2 PF07731.9 EFX03254.1 - 2.3e-43 147.0 5.4 8.7e-37 125.7 0.5 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 EFX03254.1 - 1.1e-42 144.4 1.5 5.9e-39 132.4 0.2 3.4 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EFX03254.1 - 1.2e-24 87.0 1.6 2.7e-23 82.6 0.1 3.0 3 1 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.1 EFX03254.1 - 0.065 13.1 0.0 23 4.9 0.0 3.9 3 1 0 3 3 3 0 Cupredoxin-like domain Proteasome PF00227.21 EFX03255.1 - 3.1e-35 121.1 0.0 3.8e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Chitin_synth_2 PF03142.10 EFX03256.1 - 9e-289 958.2 0.0 1.1e-288 957.9 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 EFX03256.1 - 3.5e-15 56.2 7.2 2.2e-14 53.5 5.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFX03256.1 - 4.4e-13 49.5 0.0 6.9e-12 45.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 EFX03256.1 - 1.2e-11 44.2 0.4 9.2e-09 34.9 0.0 2.5 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 EFX03256.1 - 0.00016 20.9 0.1 0.0006 19.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EFX03256.1 - 0.0082 15.8 0.0 0.031 13.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 SRPRB PF09439.5 EFX03257.1 - 6.3e-26 90.6 0.0 1.8e-25 89.2 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EFX03257.1 - 0.00053 19.9 0.0 0.00077 19.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 EFX03257.1 - 0.0015 17.7 0.0 0.029 13.6 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_30 PF13604.1 EFX03257.1 - 0.0037 16.8 0.1 0.0059 16.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX03257.1 - 0.006 16.5 0.1 0.011 15.7 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.22 EFX03257.1 - 0.0061 16.8 0.0 0.0094 16.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter GTP_EFTU PF00009.22 EFX03257.1 - 0.0082 15.5 0.0 0.043 13.2 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.6 EFX03257.1 - 0.011 14.5 0.0 0.022 13.5 0.0 1.4 2 0 0 2 2 2 0 Bacterial TniB protein ATP_bind_1 PF03029.12 EFX03257.1 - 0.013 15.0 0.0 3.4 7.1 0.0 2.3 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF258 PF03193.11 EFX03257.1 - 0.013 14.7 0.2 0.097 11.8 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX03257.1 - 0.02 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 EFX03257.1 - 0.025 14.0 0.1 1.9 7.9 0.0 2.3 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.13 EFX03257.1 - 0.078 11.9 0.0 0.15 11.0 0.0 1.4 2 0 0 2 2 2 0 Septin PWI PF01480.12 EFX03258.1 - 9.6e-21 73.6 0.0 1.5e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 PWI domain HSA PF07529.8 EFX03259.1 - 3.3e-18 65.2 1.2 3.3e-18 65.2 0.8 3.0 3 1 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.1 EFX03259.1 - 9.5e-13 48.0 0.2 9.5e-13 48.0 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFX03259.1 - 0.015 15.3 0.1 0.039 14.0 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain BCIP PF13862.1 EFX03260.1 - 1.4e-55 187.8 0.0 1.8e-55 187.4 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Methyltransf_23 PF13489.1 EFX03261.1 - 1.2e-19 70.5 0.0 2.2e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03261.1 - 1.9e-10 41.0 0.0 5.7e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03261.1 - 3.5e-07 30.8 0.0 1.9e-06 28.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03261.1 - 1.3e-06 28.8 0.0 5.8e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03261.1 - 2e-06 27.5 0.0 9.2e-06 25.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX03261.1 - 0.00046 20.5 0.0 0.0014 18.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFX03261.1 - 0.0074 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 EFX03261.1 - 0.012 15.0 0.0 0.031 13.7 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.9 EFX03261.1 - 0.017 14.5 0.0 0.051 12.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.13 EFX03261.1 - 0.02 14.0 0.0 0.063 12.3 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EFX03261.1 - 0.071 12.1 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Transferase PF02458.10 EFX03263.1 - 7e-15 54.4 0.0 9.5e-15 53.9 0.0 1.1 1 0 0 1 1 1 1 Transferase family DUF630 PF04783.7 EFX03263.1 - 0.11 12.4 0.0 0.46 10.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF630) CBFD_NFYB_HMF PF00808.18 EFX03264.1 - 7.6e-12 45.1 1.9 1.1e-11 44.5 1.3 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFX03264.1 - 1.3e-05 25.1 0.3 2e-05 24.5 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Tim44 PF04280.10 EFX03264.1 - 0.044 13.7 0.2 0.08 12.9 0.2 1.4 1 0 0 1 1 1 0 Tim44-like domain adh_short PF00106.20 EFX03265.1 - 6e-22 78.3 3.7 1e-21 77.5 2.6 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX03265.1 - 4.4e-18 65.9 0.0 5.3e-18 65.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX03265.1 - 2.9e-09 36.8 1.4 4.3e-09 36.2 0.9 1.2 1 0 0 1 1 1 1 KR domain Condensation PF00668.15 EFX03266.1 - 1e-11 44.2 0.0 1.2e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Condensation domain AATase PF07247.7 EFX03266.1 - 1.2e-11 43.8 0.0 1.2e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Alcohol acetyltransferase peroxidase PF00141.18 EFX03267.1 - 1.8e-48 165.0 0.0 3e-48 164.2 0.0 1.4 1 0 0 1 1 1 1 Peroxidase Acetyltransf_10 PF13673.1 EFX03268.1 - 6.3e-06 26.3 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX03268.1 - 0.00017 21.5 0.0 0.00031 20.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFX03268.1 - 0.077 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Nha1_C PF08619.5 EFX03269.1 - 7.1e-80 269.4 46.5 3.9e-77 260.3 32.2 2.1 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 EFX03269.1 - 4.1e-68 229.6 23.9 5e-68 229.3 16.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FlgD_ig PF13860.1 EFX03269.1 - 0.078 12.7 0.4 0.51 10.0 0.0 2.2 2 0 0 2 2 2 0 FlgD Ig-like domain YrhC PF14143.1 EFX03269.1 - 1.6 8.7 3.5 0.68 9.9 0.3 2.0 2 0 0 2 2 2 0 YrhC-like protein Statherin PF03875.8 EFX03269.1 - 1.6 8.6 3.9 0.42 10.5 0.3 1.8 2 0 0 2 2 2 0 Statherin Ribosomal_L7Ae PF01248.21 EFX03270.1 - 1.9e-22 78.5 0.1 2.5e-22 78.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EFX03270.1 - 0.00019 21.3 0.0 0.00019 21.3 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Amino_oxidase PF01593.19 EFX03271.1 - 7.2e-18 64.8 0.7 2.9e-17 62.8 0.5 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Amino_oxidase PF01593.19 EFX03272.1 - 1.8e-73 248.1 0.0 4.9e-65 220.3 0.0 2.7 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.12 EFX03272.1 - 8.4e-08 32.2 0.0 1.6e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.1 EFX03272.1 - 5e-07 29.6 0.0 1.8e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.14 EFX03272.1 - 0.0002 21.5 0.9 0.00061 19.9 0.2 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFX03272.1 - 0.0005 20.3 0.2 0.0015 18.8 0.2 1.8 1 0 0 1 1 1 1 HMG-box domain MFS_1 PF07690.11 EFX03273.1 - 8e-28 97.1 25.3 8e-28 97.1 17.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.13 EFX03274.1 - 1.1e-19 70.3 0.0 2.1e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DAO PF01266.19 EFX03276.1 - 5.4e-31 107.7 2.0 7.7e-31 107.2 1.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase ThiF PF00899.16 EFX03276.1 - 5e-05 23.1 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 ThiF family NAD_binding_8 PF13450.1 EFX03276.1 - 0.00075 19.4 0.1 0.002 18.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFX03276.1 - 0.002 18.2 0.0 0.022 14.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX03276.1 - 0.0029 17.5 0.2 0.25 11.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EFX03276.1 - 0.029 14.3 0.1 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_3 PF01494.14 EFX03276.1 - 0.05 12.6 0.0 0.072 12.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 EFX03276.1 - 0.089 12.5 0.1 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFX03276.1 - 0.11 12.8 0.1 0.29 11.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EFX03276.1 - 0.16 11.3 0.1 0.34 10.2 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DHquinase_I PF01487.10 EFX03277.1 - 7e-57 192.6 0.0 9.4e-57 192.2 0.0 1.2 1 0 0 1 1 1 1 Type I 3-dehydroquinase Ribosomal_L16 PF00252.13 EFX03278.1 - 4.2e-32 110.6 0.1 5.6e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e WGG PF10273.4 EFX03279.1 - 6.8e-23 80.5 0.2 1.2e-22 79.7 0.2 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.2 EFX03279.1 - 0.0026 17.7 0.9 0.019 15.0 0.7 2.2 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) Nucleoplasmin PF03066.10 EFX03279.1 - 0.057 12.9 4.7 0.071 12.6 3.3 1.3 1 0 0 1 1 1 0 Nucleoplasmin RXT2_N PF08595.6 EFX03279.1 - 0.37 10.5 4.1 0.59 9.9 2.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.7 EFX03279.1 - 0.56 9.4 5.8 0.68 9.1 4.0 1.1 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.1 EFX03279.1 - 1.4 9.0 7.1 2.8 8.1 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Daxx PF03344.10 EFX03279.1 - 2.2 6.6 6.5 2.5 6.4 4.5 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EFX03279.1 - 2.6 5.8 8.8 2.5 5.8 6.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 EFX03279.1 - 3.4 6.2 17.4 4.4 5.9 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sigma70_ner PF04546.8 EFX03279.1 - 9.7 5.7 10.4 17 4.9 7.2 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region LSM PF01423.17 EFX03280.1 - 2.2e-17 62.3 0.2 3.4e-17 61.7 0.1 1.3 1 0 0 1 1 1 1 LSM domain DUF2845 PF11006.3 EFX03280.1 - 0.019 14.7 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) Muted PF14942.1 EFX03280.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.5 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Glyco_hydro_20 PF00728.17 EFX03281.1 - 1.3e-80 271.2 0.0 1.6e-80 270.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 EFX03281.1 - 3.2e-19 69.8 0.1 5.3e-19 69.1 0.1 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 EFX03281.1 - 7e-07 29.8 0.4 8.6e-06 26.3 0.3 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glyoxalase_2 PF12681.2 EFX03281.1 - 0.097 13.2 0.2 6.1 7.5 0.0 3.0 3 1 0 3 3 3 0 Glyoxalase-like domain Fungal_trans PF04082.13 EFX03282.1 - 2.3e-06 26.6 2.8 2.9e-05 23.0 0.7 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03282.1 - 5.6e-05 22.9 11.3 5.6e-05 22.9 7.9 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.21 EFX03282.1 - 0.031 14.6 4.5 0.14 12.5 3.2 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type Aldedh PF00171.17 EFX03283.1 - 1.4e-134 448.9 4.2 1.3e-129 432.5 1.6 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family Homeobox PF00046.24 EFX03284.1 - 2.8e-08 33.2 0.5 5.7e-08 32.2 0.4 1.5 1 0 0 1 1 1 1 Homeobox domain DARPP-32 PF05395.7 EFX03284.1 - 0.0078 16.3 0.3 0.017 15.2 0.2 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 Methyltransf_23 PF13489.1 EFX03285.1 - 5.2e-15 55.5 0.1 7.8e-15 54.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03285.1 - 8.1e-08 31.9 0.0 3.3e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03285.1 - 1e-07 32.3 0.0 2.4e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03285.1 - 2.4e-07 31.1 0.0 8.1e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03285.1 - 1.5e-05 25.5 0.5 0.0001 22.8 0.1 2.5 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX03285.1 - 0.0005 19.2 0.0 0.002 17.3 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EFX03285.1 - 0.00094 18.2 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 EFX03285.1 - 0.0036 17.3 0.0 0.0075 16.2 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 EFX03285.1 - 0.0048 16.1 0.0 0.0072 15.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.1 EFX03285.1 - 0.012 15.9 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EFX03285.1 - 0.018 14.4 0.0 0.073 12.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain CMAS PF02353.15 EFX03285.1 - 0.028 13.4 0.0 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 EFX03286.1 - 2e-19 69.8 0.0 3e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03286.1 - 8e-11 42.2 0.0 1.5e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03286.1 - 2.6e-07 31.0 0.0 1.9e-06 28.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03286.1 - 4.2e-07 30.5 0.0 9.3e-06 26.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03286.1 - 1.6e-06 27.8 0.0 0.0059 16.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.13 EFX03286.1 - 5.7e-06 25.6 0.0 5.6e-05 22.3 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX03286.1 - 0.0003 21.0 0.0 0.0011 19.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX03286.1 - 0.0027 16.7 0.0 0.0054 15.8 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 EFX03286.1 - 0.013 14.8 0.0 0.042 13.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.4 EFX03286.1 - 0.017 14.6 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.8 EFX03286.1 - 0.049 12.7 0.0 0.12 11.4 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EFX03286.1 - 0.067 13.2 0.0 0.37 10.8 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.7 EFX03286.1 - 0.071 12.6 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.13 EFX03286.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase DHO_dh PF01180.16 EFX03287.1 - 5.6e-17 61.6 0.0 9.9e-17 60.8 0.0 1.3 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.10 EFX03287.1 - 0.074 12.1 5.0 0.12 11.4 3.5 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase TCTP PF00838.12 EFX03288.1 - 8.5e-68 227.5 1.9 9.6e-68 227.3 1.3 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Neurochondrin PF05536.6 EFX03289.1 - 4.6e-66 223.2 0.0 7.4e-66 222.5 0.0 1.3 1 0 0 1 1 1 1 Neurochondrin RIX1 PF08167.7 EFX03289.1 - 0.0061 16.2 0.3 0.22 11.1 0.0 2.9 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis MAGE PF01454.14 EFX03290.1 - 2.9e-26 92.0 0.0 1.5e-24 86.4 0.0 2.8 1 1 0 1 1 1 1 MAGE family PLRV_ORF5 PF01690.12 EFX03290.1 - 0.18 10.9 4.4 0.22 10.6 3.1 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein CDC45 PF02724.9 EFX03290.1 - 6.7 4.6 5.9 8.3 4.3 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S10 PF00450.17 EFX03291.1 - 1.9e-112 376.4 0.0 2.7e-112 375.9 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Zn_clus PF00172.13 EFX03292.1 - 2.3e-07 30.6 12.1 3.8e-07 29.9 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.19 EFX03293.1 - 1.4e-46 159.0 0.5 2.3e-46 158.3 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase CIA30 PF08547.7 EFX03293.1 - 4.6e-41 140.2 0.0 6.8e-41 139.7 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) NAD_binding_9 PF13454.1 EFX03293.1 - 0.004 16.9 0.5 0.39 10.4 0.1 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFX03293.1 - 0.012 15.6 0.5 0.23 11.4 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFX03293.1 - 0.017 15.1 0.1 6.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX03293.1 - 0.07 11.9 0.7 3.3 6.4 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Fic PF02661.13 EFX03293.1 - 0.15 12.8 0.2 0.59 10.8 0.0 2.1 3 0 0 3 3 3 0 Fic/DOC family zf-C2H2 PF00096.21 EFX03294.1 - 0.00011 22.3 15.9 0.042 14.2 0.9 4.5 3 1 0 3 3 3 3 Zinc finger, C2H2 type Raptor_N PF14538.1 EFX03294.1 - 0.0022 17.8 0.7 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain zf-C2H2_4 PF13894.1 EFX03294.1 - 0.03 14.6 28.5 0.15 12.4 0.2 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger P16-Arc PF04699.9 EFX03294.1 - 0.068 13.1 0.0 0.068 13.1 0.0 3.4 3 0 0 3 3 3 0 ARP2/3 complex 16 kDa subunit (p16-Arc) NTP_transferase PF00483.18 EFX03295.1 - 3.4e-48 164.1 0.0 7.8e-48 162.9 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.19 EFX03295.1 - 3e-15 54.9 12.8 5.1e-09 35.2 1.3 3.7 1 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EFX03295.1 - 1.2e-11 44.9 0.0 1.8e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 EFX03295.1 - 9.6e-08 31.4 7.0 1.7e-07 30.6 0.5 2.9 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.14 EFX03295.1 - 0.0027 17.3 0.0 0.0063 16.1 0.0 1.6 2 0 0 2 2 2 1 Cytidylyltransferase IspD PF01128.14 EFX03295.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase PI3Ka PF00613.15 EFX03298.1 - 7.3e-60 201.3 0.0 1.1e-59 200.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 EFX03298.1 - 6.5e-44 150.1 0.0 7.4e-43 146.7 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 EFX03298.1 - 1.8e-25 89.3 0.0 4.7e-24 84.8 0.0 2.3 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 zf-RING_2 PF13639.1 EFX03299.1 - 2e-06 27.5 0.3 2e-06 27.5 0.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_3 PF14369.1 EFX03299.1 - 0.0031 17.4 4.8 0.0068 16.3 3.4 1.6 1 0 0 1 1 1 1 zinc-finger HypA PF01155.14 EFX03299.1 - 0.02 14.5 1.3 0.022 14.4 0.1 1.6 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 EFX03299.1 - 0.024 14.5 1.4 0.062 13.2 1.0 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-C3HC4_3 PF13920.1 EFX03299.1 - 0.15 11.7 4.8 0.53 10.0 0.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX03299.1 - 1.3 8.7 8.8 3.6 7.3 0.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX03299.1 - 2.1 8.1 4.6 2.8 7.7 0.1 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFX03299.1 - 8.9 6.4 8.4 1.9 8.6 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HEAT_2 PF13646.1 EFX03300.1 - 1.3e-19 70.2 2.6 3.3e-14 52.9 0.1 3.5 2 2 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 EFX03300.1 - 3e-11 42.6 9.0 0.026 14.9 0.0 6.2 5 2 0 5 5 5 3 PBS lyase HEAT-like repeat HEAT PF02985.17 EFX03300.1 - 0.00015 21.5 4.1 0.23 11.6 0.0 5.0 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 EFX03300.1 - 0.00072 19.9 0.8 0.00072 19.9 0.5 4.2 3 2 1 4 4 4 1 HEAT-like repeat Cohesin_HEAT PF12765.2 EFX03300.1 - 0.082 12.8 0.3 0.73 9.8 0.0 2.8 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion GDPD PF03009.12 EFX03301.1 - 2.5e-28 99.2 0.0 3.4e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 EFX03301.1 - 0.0003 20.8 0.7 0.0003 20.8 0.5 2.2 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family SbcD_C PF12320.3 EFX03301.1 - 0.047 13.7 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain zf-CCHC PF00098.18 EFX03302.1 - 2.7e-54 178.6 62.1 3.3e-09 36.2 2.3 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 EFX03302.1 - 5.7e-14 51.5 43.8 0.0027 17.3 0.3 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_2 PF13696.1 EFX03302.1 - 1e-07 31.3 46.2 0.0048 16.3 0.3 7.2 2 2 5 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.1 EFX03302.1 - 1.1e-07 31.5 42.6 0.12 12.1 0.5 6.9 3 2 4 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.1 EFX03302.1 - 0.0018 17.8 52.8 0.058 13.0 1.5 6.7 5 2 2 7 7 7 6 Zinc knuckle Mucin PF01456.12 EFX03304.1 - 0.13 12.0 6.9 0.25 11.1 4.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Med21 PF11221.3 EFX03305.1 - 1.4e-41 141.8 6.9 1.6e-41 141.6 4.8 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex CENP-Q PF13094.1 EFX03305.1 - 0.017 15.1 7.4 0.017 15.1 5.1 1.6 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Striatin PF08232.7 EFX03305.1 - 0.018 15.3 2.5 0.018 15.3 1.7 1.8 2 0 0 2 2 2 0 Striatin family TMCO5 PF14992.1 EFX03305.1 - 0.027 13.5 2.9 0.031 13.4 2.0 1.2 1 0 0 1 1 1 0 TMCO5 family Med9 PF07544.8 EFX03305.1 - 0.051 13.3 10.3 0.95 9.2 5.1 3.0 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TMF_DNA_bd PF12329.3 EFX03305.1 - 0.053 13.3 7.8 0.29 10.9 5.4 2.1 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF3802 PF12290.3 EFX03305.1 - 1 9.7 3.6 2.2 8.5 0.7 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3802) APG6 PF04111.7 EFX03305.1 - 1.1 8.2 7.0 1.2 8.1 4.4 1.3 1 1 0 1 1 1 0 Autophagy protein Apg6 Fib_alpha PF08702.5 EFX03305.1 - 1.4 9.0 3.9 0.56 10.3 0.5 1.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family IncA PF04156.9 EFX03305.1 - 5.5 6.5 10.8 4.1 6.9 6.3 1.6 1 1 0 1 1 1 0 IncA protein Pyr_redox_2 PF07992.9 EFX03306.1 - 1.7e-30 106.3 0.1 2.3e-30 106.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX03306.1 - 4.6e-20 71.8 0.7 4.1e-14 52.7 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 EFX03306.1 - 3.6e-18 65.5 0.0 7.9e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GIDA PF01134.17 EFX03306.1 - 1.4e-06 27.4 2.2 2.3e-06 26.7 1.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.19 EFX03306.1 - 1.9e-06 27.0 2.1 1.7e-05 23.9 0.4 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX03306.1 - 3e-05 24.1 0.2 0.001 19.1 0.2 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFX03306.1 - 0.00021 20.4 4.4 0.0022 17.1 1.6 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 EFX03306.1 - 0.0012 17.8 0.0 0.073 11.9 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.19 EFX03306.1 - 0.0028 16.5 5.5 0.0028 16.5 3.8 2.2 1 1 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 EFX03306.1 - 0.0042 16.2 0.1 0.0081 15.2 0.1 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 EFX03306.1 - 0.0065 15.5 2.4 0.26 10.2 0.2 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 EFX03306.1 - 0.025 14.5 4.9 0.093 12.7 1.4 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFX03306.1 - 0.033 12.6 0.3 0.48 8.8 0.5 2.1 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.1 EFX03306.1 - 0.19 11.9 0.7 3 8.1 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 EFX03306.1 - 0.27 10.8 1.5 4.4 6.9 0.5 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Oxysterol_BP PF01237.13 EFX03307.1 - 1.2e-81 274.0 0.0 1.5e-81 273.6 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Glycogen_syn PF05693.8 EFX03308.1 - 0 1138.4 0.0 0 1138.2 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 EFX03308.1 - 1.9e-06 27.4 0.0 0.0065 15.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 EFX03308.1 - 3.6e-06 26.6 0.0 7.3e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.1 EFX03308.1 - 0.00011 22.3 0.0 0.00025 21.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain BAF1_ABF1 PF04684.8 EFX03308.1 - 0.015 14.1 0.2 0.023 13.5 0.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MFS_1 PF07690.11 EFX03310.1 - 3.8e-14 52.1 44.3 2.3e-12 46.3 11.5 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily Vac7 PF12751.2 EFX03311.1 - 2.5e-111 372.2 2.7 2.5e-111 372.2 1.9 2.4 3 0 0 3 3 3 1 Vacuolar segregation subunit 7 But2 PF09792.4 EFX03314.1 - 3.3e-31 107.9 1.9 4.1e-31 107.6 1.3 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Mid2 PF04478.7 EFX03316.1 - 2.5e-05 23.7 1.0 2.5e-05 23.7 0.7 1.8 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 EFX03316.1 - 4.6e-05 22.6 10.2 0.00017 20.7 7.1 2.0 1 1 0 1 1 1 1 Transmembrane alpha-helix domain MGC-24 PF05283.6 EFX03316.1 - 0.002 17.9 4.4 0.0031 17.3 3.1 1.4 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24) DUF1517 PF07466.6 EFX03316.1 - 0.0024 16.8 0.8 0.0041 16.1 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1517) Glycophorin_A PF01102.13 EFX03316.1 - 0.081 12.6 4.8 0.21 11.3 3.4 1.7 1 1 0 1 1 1 0 Glycophorin A Syndecan PF01034.15 EFX03316.1 - 0.09 12.4 1.8 0.19 11.4 1.3 1.5 1 0 0 1 1 1 0 Syndecan domain Ribosomal_L7Ae PF01248.21 EFX03317.1 - 1.3e-24 85.5 0.0 1.5e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DEAD PF00270.24 EFX03318.1 - 2.6e-46 157.2 0.0 2.1e-43 147.7 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX03318.1 - 1.4e-28 98.5 0.0 8.7e-28 96.0 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX03318.1 - 0.0029 17.4 0.0 0.0087 15.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 EFX03318.1 - 0.014 13.8 0.0 0.028 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) Fungal_trans PF04082.13 EFX03319.1 - 2.1e-38 131.7 0.4 2.1e-38 131.7 0.3 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03319.1 - 1.1e-08 34.8 14.6 2e-08 33.9 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FKBP_N PF01346.13 EFX03319.1 - 0.0079 16.2 4.3 2.2 8.3 4.2 2.7 3 0 0 3 3 3 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Pterin_4a PF01329.14 EFX03320.1 - 2.5e-26 91.2 0.0 3.2e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Mito_fiss_reg PF05308.6 EFX03321.1 - 0.051 12.9 14.5 0.53 9.6 1.5 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF2360 PF10152.4 EFX03321.1 - 1.1 9.4 6.1 3.7 7.8 0.4 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) adh_short PF00106.20 EFX03322.1 - 1.3e-12 47.9 14.9 2.5e-12 47.0 0.0 3.3 3 1 1 4 4 4 1 short chain dehydrogenase KR PF08659.5 EFX03322.1 - 3.6e-08 33.2 0.0 3.6e-08 33.2 0.0 2.5 2 0 0 2 2 2 1 KR domain E1-N PF14463.1 EFX03322.1 - 0.0096 15.5 0.2 0.0096 15.5 0.2 2.2 2 0 0 2 2 2 1 E1 N-terminal domain Tropomyosin PF00261.15 EFX03324.1 - 0.43 9.6 27.4 0.13 11.3 2.9 2.8 1 1 0 2 2 2 0 Tropomyosin Tropomyosin_1 PF12718.2 EFX03324.1 - 0.51 10.1 26.5 0.28 11.0 14.9 2.8 2 1 1 3 3 3 0 Tropomyosin like IncA PF04156.9 EFX03324.1 - 0.87 9.1 34.7 2 7.9 12.0 3.0 1 1 2 3 3 3 0 IncA protein Phage_GP20 PF06810.6 EFX03324.1 - 1.1 8.7 13.8 0.38 10.1 0.4 3.4 1 1 2 3 3 3 0 Phage minor structural protein GP20 HR1 PF02185.11 EFX03324.1 - 1.2 8.9 25.3 0.29 10.9 0.1 4.5 3 1 1 4 4 4 0 Hr1 repeat CENP-F_leu_zip PF10473.4 EFX03324.1 - 1.5 8.7 32.0 0.034 13.9 4.4 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 EFX03324.1 - 1.7 6.9 12.9 1.7 7.0 8.2 1.4 2 0 0 2 2 2 0 AAA domain CENP-Q PF13094.1 EFX03324.1 - 8.5 6.3 29.1 50 3.8 7.9 3.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit PH PF00169.24 EFX03325.1 - 7e-06 26.1 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 PH domain Apolipoprotein PF01442.13 EFX03325.1 - 0.0035 16.8 0.2 0.0076 15.7 0.1 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain CK2S PF15011.1 EFX03325.1 - 0.036 13.8 1.7 2 8.1 0.0 3.0 2 1 0 3 3 3 0 Casein Kinase 2 substrate HeLo PF14479.1 EFX03326.1 - 0.0025 17.5 5.4 0.13 11.9 1.0 2.9 2 1 0 2 2 2 1 Prion-inhibition and propagation Bac_rhamnosid PF05592.6 EFX03327.1 - 1.1e-27 96.4 0.0 1.2e-16 60.0 0.0 3.9 2 1 1 3 3 3 3 Bacterial alpha-L-rhamnosidase Ribonuclease_3 PF00636.21 EFX03328.1 - 4.4e-07 30.3 0.0 8.5e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EFX03328.1 - 8.3e-06 25.7 0.0 0.078 12.9 0.0 2.2 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.20 EFX03328.1 - 6.5e-05 23.4 0.0 0.00013 22.4 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Thioredoxin PF00085.15 EFX03329.1 - 4.1e-45 151.7 0.2 1.9e-24 85.3 0.0 3.3 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 EFX03329.1 - 4.7e-11 42.8 0.0 0.0013 18.5 0.0 3.8 3 1 2 5 5 5 3 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX03329.1 - 9.6e-09 35.2 0.2 0.0029 17.6 0.0 3.8 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.1 EFX03329.1 - 8e-08 32.2 0.0 0.00023 21.1 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EFX03329.1 - 8.2e-08 32.4 4.6 0.0019 18.3 0.0 4.3 4 1 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_3 PF13192.1 EFX03329.1 - 9.9e-08 31.6 0.5 0.011 15.4 0.1 3.9 4 1 0 4 4 4 2 Thioredoxin domain AhpC-TSA PF00578.16 EFX03329.1 - 0.00012 21.7 1.7 0.67 9.6 0.0 3.8 4 0 0 4 4 4 2 AhpC/TSA family HyaE PF07449.6 EFX03329.1 - 0.00016 21.5 0.0 0.28 11.0 0.0 3.1 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE 7TM_GPCR_Srh PF10318.4 EFX03329.1 - 0.2 10.4 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh zf-FCS PF06467.9 EFX03329.1 - 4 7.1 5.5 0.57 9.8 0.4 2.1 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Thioredoxin_4 PF13462.1 EFX03329.1 - 9.5 6.2 7.3 18 5.2 0.3 3.6 4 0 0 4 4 4 0 Thioredoxin Annexin PF00191.15 EFX03330.1 - 6.2e-14 51.6 0.3 0.017 14.9 0.0 4.4 4 0 0 4 4 4 4 Annexin MRP-L27 PF09809.4 EFX03331.1 - 4.8e-15 55.1 1.2 6e-15 54.8 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Transferase PF02458.10 EFX03332.1 - 1.3e-18 66.7 0.0 1.8e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Transferase family RINGv PF12906.2 EFX03333.1 - 4.3e-17 61.8 8.3 7e-17 61.2 5.8 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 EFX03333.1 - 0.025 14.4 8.4 0.041 13.6 5.8 1.4 1 0 0 1 1 1 0 Ring finger domain zf-Apc11 PF12861.2 EFX03333.1 - 0.14 11.9 2.4 0.33 10.8 1.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 EFX03333.1 - 2 8.4 4.4 3.7 7.5 3.1 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain DHBP_synthase PF00926.14 EFX03335.1 - 5e-68 228.1 0.0 1.7e-67 226.4 0.0 1.7 1 1 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase MBA1 PF07961.6 EFX03336.1 - 4.2e-06 25.7 0.0 8.6e-06 24.7 0.0 1.7 1 1 0 1 1 1 1 MBA1-like protein DEAD PF00270.24 EFX03337.1 - 1.2e-43 148.4 0.0 1.8e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX03337.1 - 1.1e-23 82.8 0.1 2.2e-23 81.8 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX03337.1 - 0.0035 17.1 0.0 0.021 14.6 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 EFX03337.1 - 0.045 12.8 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Transket_pyr PF02779.19 EFX03338.1 - 1.9e-44 151.3 0.0 2.6e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EFX03338.1 - 4.4e-28 97.7 0.0 7.7e-28 96.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain Sugar_tr PF00083.19 EFX03339.1 - 2.4e-115 385.6 25.3 2.8e-115 385.4 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03339.1 - 3.7e-21 75.2 33.2 6.9e-18 64.4 17.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX03339.1 - 8.8e-10 37.5 20.6 3.4e-06 25.7 4.2 3.2 3 0 0 3 3 3 2 MFS/sugar transport protein DUF1744 PF08490.7 EFX03340.1 - 6.5e-148 492.5 0.0 9.2e-148 492.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 EFX03340.1 - 2.6e-62 210.5 0.1 4.6e-62 209.7 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 EFX03340.1 - 7.1e-21 74.5 0.1 1.7e-20 73.3 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 EFX03340.1 - 2.9e-09 36.7 0.1 7.2e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 EFX03340.1 - 2.1e-05 24.3 0.0 8.1e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily Glyco_hydro_18 PF00704.23 EFX03341.1 - 6.6e-96 321.7 1.0 7.5e-96 321.5 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CFEM PF05730.6 EFX03342.1 - 3.4e-10 39.5 12.1 8.8e-10 38.2 8.4 1.7 1 0 0 1 1 1 1 CFEM domain DUF3767 PF12597.3 EFX03343.1 - 6.2e-36 122.6 0.2 6.2e-36 122.6 0.2 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) DUF4557 PF15101.1 EFX03343.1 - 0.12 12.2 3.4 0.14 11.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) G0-G1_switch_2 PF15103.1 EFX03343.1 - 0.53 10.5 3.4 0.23 11.6 0.4 1.8 2 0 0 2 2 2 0 G0/G1 switch protein 2 OSTbeta PF15048.1 EFX03343.1 - 0.68 10.0 4.0 0.32 11.0 0.6 1.9 2 1 0 2 2 2 0 Organic solute transporter subunit beta protein Pex14_N PF04695.8 EFX03343.1 - 6.4 6.8 9.1 3.4 7.6 0.3 2.3 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region VID27 PF08553.5 EFX03344.1 - 0 1087.2 0.0 0 1087.1 0.0 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein Daxx PF03344.10 EFX03344.1 - 1 7.7 13.1 1.8 6.9 9.1 1.3 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 EFX03344.1 - 1.8 6.4 12.8 3.1 5.7 8.9 1.2 1 0 0 1 1 1 0 CDC45-like protein DnaJ PF00226.26 EFX03345.1 - 1.5e-08 34.1 0.2 2.6e-08 33.4 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain AAA PF00004.24 EFX03346.1 - 1.2e-42 145.2 0.0 2.3e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EFX03346.1 - 8.9e-28 95.9 0.1 4.4e-27 93.7 0.1 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 EFX03346.1 - 3.1e-23 81.4 3.3 3.1e-23 81.4 2.3 2.2 3 0 0 3 3 2 1 MIT (microtubule interacting and transport) domain RNA_helicase PF00910.17 EFX03346.1 - 3.3e-06 27.2 0.2 0.0093 16.1 0.0 3.6 3 0 0 3 3 3 1 RNA helicase AAA_17 PF13207.1 EFX03346.1 - 6.5e-06 26.9 0.1 4.1e-05 24.3 0.0 2.6 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 EFX03346.1 - 8.5e-06 24.9 0.0 1.7e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFX03346.1 - 9.6e-06 25.7 0.1 0.0012 19.0 0.0 2.7 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EFX03346.1 - 3e-05 23.5 0.0 6.4e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 EFX03346.1 - 3.2e-05 23.8 0.0 6.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFX03346.1 - 3.3e-05 23.6 0.0 0.00023 20.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EFX03346.1 - 9.7e-05 21.2 0.0 0.00018 20.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 EFX03346.1 - 0.0001 22.3 0.0 0.00089 19.2 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.8 EFX03346.1 - 0.00011 21.2 0.0 0.00049 19.1 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 EFX03346.1 - 0.00018 20.9 0.1 0.15 11.4 0.1 2.6 1 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EFX03346.1 - 0.00024 20.9 0.0 0.00063 19.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EFX03346.1 - 0.0015 18.5 0.0 0.0099 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 EFX03346.1 - 0.0046 17.2 0.1 0.015 15.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.1 EFX03346.1 - 0.0052 16.3 0.1 0.017 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EFX03346.1 - 0.0056 15.7 0.2 0.14 11.1 0.1 2.5 1 1 0 1 1 1 1 Zeta toxin ResIII PF04851.10 EFX03346.1 - 0.011 15.5 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.16 EFX03346.1 - 0.012 14.8 0.2 0.061 12.4 0.0 2.2 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EFX03346.1 - 0.013 15.2 0.0 0.062 13.0 0.0 2.2 1 0 0 1 1 1 0 Part of AAA domain Arch_ATPase PF01637.13 EFX03346.1 - 0.017 14.8 0.7 0.15 11.6 0.0 2.5 2 1 1 3 3 3 0 Archaeal ATPase Parvo_NS1 PF01057.12 EFX03346.1 - 0.03 13.1 0.0 0.073 11.9 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NACHT PF05729.7 EFX03346.1 - 0.03 13.9 0.0 0.32 10.6 0.0 2.2 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.11 EFX03346.1 - 0.031 13.5 0.0 0.091 11.9 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 EFX03346.1 - 0.038 13.0 0.0 5.8 5.9 0.0 2.3 1 1 1 2 2 2 0 KaiC Torsin PF06309.6 EFX03346.1 - 0.043 13.6 0.1 0.11 12.4 0.0 1.6 2 0 0 2 2 1 0 Torsin Guanylate_kin PF00625.16 EFX03346.1 - 0.093 12.1 0.1 0.39 10.1 0.0 2.1 2 0 0 2 2 2 0 Guanylate kinase Sigma54_activat PF00158.21 EFX03346.1 - 0.11 11.9 0.0 0.37 10.2 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_21 PF13304.1 EFX03346.1 - 0.19 11.6 0.2 3.2 7.6 0.0 2.3 1 1 1 2 2 2 0 AAA domain DUF4398 PF14346.1 EFX03346.1 - 1.6 8.7 5.2 0.64 10.1 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) zf-MYND PF01753.13 EFX03347.1 - 1e-09 38.0 7.7 1e-09 38.0 5.3 2.7 2 0 0 2 2 2 1 MYND finger Fungal_trans PF04082.13 EFX03347.1 - 0.13 11.0 0.3 0.27 10.0 0.2 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Reo_sigmaC PF04582.7 EFX03348.1 - 0.0002 20.6 19.0 0.0007 18.8 0.8 4.4 3 2 1 4 4 4 2 Reovirus sigma C capsid protein DUF641 PF04859.7 EFX03348.1 - 0.0029 17.3 18.0 0.61 9.8 0.2 4.5 3 1 1 4 4 4 2 Plant protein of unknown function (DUF641) ATG16 PF08614.6 EFX03348.1 - 0.0042 16.9 31.7 0.033 13.9 7.6 3.4 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) FlaC_arch PF05377.6 EFX03348.1 - 0.0074 16.1 0.5 10 6.0 0.0 3.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.3 EFX03348.1 - 0.0077 16.0 29.7 0.2 11.4 4.5 6.1 5 2 1 6 6 6 3 TATA element modulatory factor 1 DNA binding BMC PF00936.14 EFX03348.1 - 0.014 15.0 2.1 0.22 11.2 0.5 3.1 2 1 0 2 2 2 0 BMC domain NBP1 PF08537.5 EFX03348.1 - 0.015 14.5 0.4 0.015 14.5 0.3 1.8 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 AAA_13 PF13166.1 EFX03348.1 - 0.046 12.1 10.8 0.53 8.6 0.7 3.2 3 0 0 3 3 3 0 AAA domain Spc7 PF08317.6 EFX03348.1 - 0.16 10.5 15.4 0.065 11.8 2.5 3.9 3 1 0 4 4 4 0 Spc7 kinetochore protein Filament PF00038.16 EFX03348.1 - 0.34 10.3 32.5 1.1 8.6 5.3 3.9 3 1 0 3 3 3 0 Intermediate filament protein DUF4463 PF14703.1 EFX03348.1 - 0.35 11.3 1.6 9.7 6.7 0.1 3.1 3 0 0 3 3 2 0 Domain of unknown function (DUF4463) TPR_MLP1_2 PF07926.7 EFX03348.1 - 0.42 10.3 23.4 2.7 7.7 3.1 4.7 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein Fmp27_WPPW PF10359.4 EFX03348.1 - 0.54 8.6 11.9 1.9 6.8 0.6 2.5 2 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain TBPIP PF07106.8 EFX03348.1 - 0.56 9.7 14.9 4.9 6.6 0.0 4.6 3 2 1 5 5 5 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Cluap1 PF10234.4 EFX03348.1 - 0.59 9.3 18.7 0.058 12.6 0.3 3.8 2 1 0 3 3 3 0 Clusterin-associated protein-1 Mnd1 PF03962.10 EFX03348.1 - 0.67 9.5 13.1 0.92 9.1 2.2 3.9 3 1 0 3 3 3 0 Mnd1 family Atg14 PF10186.4 EFX03348.1 - 1.3 7.9 25.6 10 4.9 5.3 4.1 3 1 0 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 IFT57 PF10498.4 EFX03348.1 - 2.1 6.9 8.1 12 4.5 2.2 2.5 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Seryl_tRNA_N PF02403.17 EFX03348.1 - 4.1 7.4 23.7 1 9.4 3.1 5.0 4 1 3 7 7 6 0 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.6 EFX03348.1 - 5.9 6.3 22.5 2 7.8 0.1 4.5 3 2 2 6 6 6 0 Phage minor structural protein GP20 PBP PF01161.15 EFX03350.1 - 4.3e-05 23.4 0.0 4.4e-05 23.3 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein TFIIE_beta PF02186.10 EFX03351.1 - 0.025 14.5 0.0 0.062 13.3 0.0 1.6 1 0 0 1 1 1 0 TFIIE beta subunit core domain Cpn60_TCP1 PF00118.19 EFX03352.1 - 5.9e-149 496.7 0.5 6.7e-149 496.6 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-H2C2 PF09337.5 EFX03353.1 - 2.5e-21 74.8 8.0 2.6e-21 74.7 4.2 2.1 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger Acetyltransf_4 PF13420.1 EFX03353.1 - 0.0021 18.0 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX03353.1 - 0.018 15.0 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 EFX03353.1 - 0.042 14.0 0.0 0.095 12.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Imm47 PF15586.1 EFX03353.1 - 0.25 11.2 0.0 0.44 10.3 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 47 PAT1 PF09770.4 EFX03353.1 - 1 7.5 22.3 1.6 6.8 15.5 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2263 PF10021.4 EFX03354.1 - 5.2e-14 52.4 0.0 9.6e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Chorion_2 PF03964.10 EFX03354.1 - 0.018 15.5 3.0 0.018 15.5 2.1 2.7 3 0 0 3 3 3 0 Chorion family 2 Secretin_N_2 PF07655.8 EFX03354.1 - 0.029 14.7 9.9 0.068 13.5 6.9 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain TraG-D_C PF12696.2 EFX03354.1 - 0.44 10.4 3.3 0.97 9.3 2.3 1.6 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG Pex14_N PF04695.8 EFX03354.1 - 0.56 10.2 6.3 1.4 8.9 4.4 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Macoilin PF09726.4 EFX03354.1 - 2.3 6.4 10.7 3.1 5.9 7.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Period_C PF12114.3 EFX03354.1 - 2.9 7.4 15.8 5.4 6.5 11.0 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region tRNA-synt_2 PF00152.15 EFX03355.1 - 4e-66 223.0 0.0 6.1e-66 222.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFX03355.1 - 1.9e-05 24.4 0.0 2.9e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SR-25 PF10500.4 EFX03355.1 - 9.6 5.6 9.0 16 4.9 6.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WSC PF01822.14 EFX03356.1 - 2.4e-12 46.6 14.6 2.4e-12 46.6 10.1 2.3 2 0 0 2 2 2 1 WSC domain SKG6 PF08693.5 EFX03356.1 - 1.2e-06 27.6 1.5 1.2e-06 27.6 1.0 2.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF1191 PF06697.7 EFX03356.1 - 6e-05 22.0 0.2 9e-05 21.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) Podoplanin PF05808.6 EFX03356.1 - 0.00041 19.9 3.7 0.00086 18.9 2.5 1.5 1 0 0 1 1 1 1 Podoplanin DUF4366 PF14283.1 EFX03356.1 - 0.001 18.5 0.0 0.0021 17.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) DUF4448 PF14610.1 EFX03356.1 - 0.0016 17.9 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF515 PF04415.7 EFX03356.1 - 0.013 13.8 10.1 0.02 13.1 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) V4R PF02830.13 EFX03356.1 - 0.043 13.6 1.4 0.25 11.2 0.0 2.7 3 0 0 3 3 3 0 V4R domain Ctr PF04145.10 EFX03356.1 - 0.21 11.6 0.9 3.7 7.5 0.0 2.4 1 1 1 2 2 2 0 Ctr copper transporter family Macoilin PF09726.4 EFX03356.1 - 2 6.6 5.2 2.7 6.1 3.6 1.2 1 0 0 1 1 1 0 Transmembrane protein PIP5K PF01504.13 EFX03358.1 - 7.5e-85 284.0 0.1 1.1e-84 283.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cu-oxidase PF00394.17 EFX03359.1 - 2.8e-33 115.0 0.0 4.7e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX03359.1 - 3e-24 85.0 1.3 1.3e-23 83.0 0.3 2.4 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 EFX03359.1 - 0.00047 19.8 4.8 0.13 11.9 0.1 4.2 3 1 1 4 4 4 3 Multicopper oxidase MFS_1 PF07690.11 EFX03361.1 - 8.7e-40 136.5 58.0 7.9e-38 130.0 40.0 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Arginase PF00491.16 EFX03362.1 - 4.1e-73 246.0 0.2 4.8e-73 245.8 0.1 1.0 1 0 0 1 1 1 1 Arginase family COX6B PF02297.12 EFX03363.1 - 7.1e-18 64.3 0.3 8.8e-18 64.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb SMC_N PF02463.14 EFX03364.1 - 1.2e-77 260.0 0.0 2.7e-77 258.9 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EFX03364.1 - 4.8e-27 94.3 0.0 1.5e-26 92.6 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EFX03364.1 - 1.8e-13 51.1 1.3 1.8e-05 24.8 0.2 2.6 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX03364.1 - 0.00023 20.6 0.0 0.00054 19.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tektin PF03148.9 EFX03364.1 - 0.0003 19.4 6.4 0.0003 19.4 4.4 6.4 4 2 3 7 7 7 2 Tektin family AAA_13 PF13166.1 EFX03364.1 - 1.5 7.2 76.4 0.24 9.7 14.7 5.0 3 2 1 4 4 4 0 AAA domain PH PF00169.24 EFX03365.1 - 2e-09 37.5 0.1 3.9e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 PH domain Prominin PF05478.6 EFX03365.1 - 0.0031 15.1 0.4 0.0046 14.5 0.3 1.2 1 0 0 1 1 1 1 Prominin Proteasome PF00227.21 EFX03365.1 - 0.12 11.6 0.0 0.28 10.4 0.0 1.6 1 0 0 1 1 1 0 Proteasome subunit Linker_histone PF00538.14 EFX03366.1 - 8.6e-24 83.4 0.3 1.9e-23 82.3 0.2 1.6 1 0 0 1 1 1 1 linker histone H1 and H5 family CCDC144C PF14915.1 EFX03366.1 - 0.098 11.5 0.1 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region FliE PF02049.13 EFX03366.1 - 6.5 6.8 7.4 0.3 11.1 0.3 2.3 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE Adaptin_N PF01602.15 EFX03367.1 - 2.7e-148 494.6 6.3 3.7e-148 494.1 4.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EFX03367.1 - 8e-27 94.2 1.5 6.5e-26 91.2 0.0 2.8 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFX03367.1 - 1.2e-16 60.7 0.2 2.2e-07 31.0 0.0 4.6 2 2 3 5 5 5 4 HEAT repeats HEAT PF02985.17 EFX03367.1 - 2e-11 42.9 1.8 0.016 15.1 0.0 5.4 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 EFX03367.1 - 5.9e-05 23.4 0.1 2 8.9 0.0 5.1 4 1 1 5 5 5 1 HEAT-like repeat Arm PF00514.18 EFX03367.1 - 0.0095 15.7 1.5 5.7 6.9 0.0 4.7 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.3 EFX03367.1 - 0.019 14.3 0.3 1.6 7.9 0.0 3.4 3 1 1 4 4 4 0 CLASP N terminal UNC45-central PF11701.3 EFX03367.1 - 0.037 13.6 0.3 0.38 10.3 0.0 2.4 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central Ribosomal_S27 PF01599.14 EFX03368.1 - 3.6e-29 100.3 2.1 5.8e-29 99.6 1.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S27a Stig1 PF04885.8 EFX03368.1 - 0.013 15.6 0.2 0.016 15.4 0.2 1.1 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 IBR PF01485.16 EFX03368.1 - 0.043 13.6 0.9 0.064 13.1 0.6 1.4 1 1 0 1 1 1 0 IBR domain Fer2_3 PF13085.1 EFX03368.1 - 0.094 12.5 0.8 0.15 11.8 0.6 1.4 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Prenylcys_lyase PF07156.9 EFX03369.1 - 1.2e-28 100.0 0.0 2.1e-28 99.2 0.0 1.3 1 1 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.1 EFX03369.1 - 2.6e-13 49.8 0.0 5.4e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFX03369.1 - 1.9e-08 33.8 0.0 7.7e-08 31.8 0.0 2.0 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.19 EFX03369.1 - 2e-05 23.6 0.1 4.9e-05 22.3 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX03369.1 - 0.00045 20.1 0.9 0.028 14.2 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX03369.1 - 0.00049 19.9 0.1 0.0022 17.7 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Malic_M PF03949.10 EFX03369.1 - 0.012 15.2 0.2 0.021 14.3 0.2 1.3 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain Thi4 PF01946.12 EFX03369.1 - 0.058 12.4 0.3 0.12 11.4 0.2 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 EFX03369.1 - 0.086 12.8 0.2 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Strep_67kDa_ant PF06100.6 EFX03369.1 - 0.096 11.0 0.5 7.5 4.7 0.1 2.2 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family ApbA PF02558.11 EFX03369.1 - 0.13 11.6 0.1 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GMC_oxred_N PF00732.14 EFX03370.1 - 1.7e-52 178.4 0.2 2.1e-52 178.1 0.1 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX03370.1 - 9.3e-38 129.7 0.0 1.7e-37 128.8 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EFX03370.1 - 2.7e-08 33.1 0.3 4.1e-05 22.6 0.2 2.4 3 0 0 3 3 3 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFX03370.1 - 5.8e-05 22.1 0.2 0.0001 21.3 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFX03370.1 - 0.0084 16.1 0.5 0.038 14.0 0.4 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EFX03370.1 - 0.012 15.6 0.7 0.84 9.6 0.1 2.7 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX03370.1 - 0.049 12.0 0.4 0.84 8.0 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.9 EFX03370.1 - 0.075 12.8 0.5 0.33 10.8 0.3 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Gar1 PF04410.9 EFX03371.1 - 2.7e-42 143.8 0.0 3.6e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region PDCD2_C PF04194.8 EFX03374.1 - 1.3e-49 167.9 0.0 1.3e-49 167.9 0.0 2.9 4 0 0 4 4 4 1 Programmed cell death protein 2, C-terminal putative domain ESCRT-II PF05871.7 EFX03374.1 - 1.1e-41 142.0 0.0 2.1e-41 141.1 0.0 1.5 1 1 0 1 1 1 1 ESCRT-II complex subunit Clathrin PF00637.15 EFX03376.1 - 7e-21 74.3 1.0 1.2e-19 70.3 0.2 2.4 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 EFX03376.1 - 0.0036 17.1 1.3 0.014 15.1 0.9 2.0 1 1 0 1 1 1 1 Ring finger domain WD40 PF00400.27 EFX03376.1 - 0.0059 16.4 0.0 0.8 9.6 0.0 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Vps39_1 PF10366.4 EFX03376.1 - 0.022 14.7 0.3 0.29 11.1 0.1 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 PTCB-BRCT PF12738.2 EFX03377.1 - 2.4e-28 97.7 0.2 1.7e-17 63.0 0.0 4.6 5 0 0 5 5 5 3 twin BRCT domain BRCT PF00533.21 EFX03377.1 - 1.5e-20 73.1 0.0 1.6e-05 24.9 0.0 6.1 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain Acyl-CoA_dh_1 PF00441.19 EFX03379.1 - 6.3e-41 139.9 0.9 9.1e-41 139.4 0.6 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EFX03379.1 - 5.7e-21 73.7 0.2 1.1e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.23 EFX03379.1 - 2.4e-19 68.9 0.2 4.2e-19 68.1 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.11 EFX03379.1 - 1e-17 64.7 0.0 2.1e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EFX03379.1 - 4.9e-07 30.0 0.1 8.7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_transf_20 PF00982.16 EFX03380.1 - 4.6e-185 615.6 0.0 5.3e-185 615.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Ribosomal_S26e PF01283.14 EFX03381.1 - 1.6e-50 170.1 9.7 1.8e-50 169.9 6.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.2 EFX03381.1 - 0.048 14.0 1.0 1.1 9.6 0.4 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF2419 PF10343.4 EFX03381.1 - 0.07 12.3 0.0 0.084 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2419) Zn_ribbon_2 PF12674.2 EFX03381.1 - 0.082 13.2 0.3 8.5 6.8 0.0 2.3 1 1 1 2 2 2 0 Putative zinc ribbon domain DUF1918 PF08940.6 EFX03381.1 - 0.09 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) ELYS PF13934.1 EFX03382.1 - 6.9e-62 209.1 0.1 8e-62 208.9 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore complex assembly HET PF06985.6 EFX03383.1 - 4.2e-15 56.1 0.0 1.4e-14 54.4 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) CPSF100_C PF13299.1 EFX03384.1 - 1.9e-37 128.9 0.2 3.9e-36 124.6 0.0 2.5 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 EFX03384.1 - 3.4e-23 81.9 0.0 1.1e-22 80.3 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 EFX03384.1 - 0.018 14.7 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFX03384.1 - 0.098 12.1 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Nucleoplasmin PF03066.10 EFX03384.1 - 1 8.8 9.0 2.2 7.7 4.3 2.3 2 0 0 2 2 2 0 Nucleoplasmin CDC45 PF02724.9 EFX03384.1 - 2.7 5.9 5.0 1.5 6.7 0.4 2.0 2 0 0 2 2 2 0 CDC45-like protein VID27 PF08553.5 EFX03384.1 - 4.8 5.2 9.8 2.6 6.1 0.1 2.1 2 0 0 2 2 2 0 VID27 cytoplasmic protein CN_hydrolase PF00795.17 EFX03385.1 - 2.3e-23 82.4 0.0 7.3e-23 80.8 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Nop PF01798.13 EFX03386.1 - 4.6e-57 191.5 0.1 9.8e-57 190.4 0.1 1.6 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EFX03386.1 - 4.8e-24 83.9 0.0 9e-24 83.0 0.0 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EFX03386.1 - 2.3e-19 69.2 2.7 1.2e-18 67.0 0.0 3.1 3 0 0 3 3 3 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.6 EFX03386.1 - 1.4 8.5 17.9 2.4 7.7 12.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1993 PF09351.5 EFX03387.1 - 8.6e-28 97.2 0.0 1e-27 97.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) JAB PF01398.16 EFX03389.1 - 2.5e-12 46.5 0.0 4e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 EFX03389.1 - 9.9e-06 25.0 0.0 2.7e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain USP8_dimer PF08969.6 EFX03389.1 - 0.00021 21.2 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 USP8 dimerisation domain Cpn60_TCP1 PF00118.19 EFX03390.1 - 4.9e-139 464.0 1.2 5.6e-139 463.8 0.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MR_MLE PF01188.16 EFX03390.1 - 0.085 13.4 0.1 1.3 9.5 0.0 2.7 1 1 1 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Rep_fac_C PF08542.6 EFX03390.1 - 0.11 12.5 0.1 8 6.5 0.0 2.7 2 0 0 2 2 2 0 Replication factor C C-terminal domain HSDR_N_2 PF13588.1 EFX03390.1 - 0.16 11.7 0.8 3.6 7.4 0.1 2.8 3 0 0 3 3 3 0 Type I restriction enzyme R protein N terminus (HSDR_N) zf-H2C2_2 PF13465.1 EFX03391.1 - 1e-08 35.0 12.3 0.0002 21.4 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFX03391.1 - 1.8e-05 24.8 30.5 0.00035 20.7 4.8 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX03391.1 - 0.2 12.0 29.1 0.34 11.3 4.3 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger eIF3_N PF09440.5 EFX03392.1 - 2.5e-48 163.5 1.7 7e-48 162.1 1.2 1.8 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 EFX03392.1 - 7.7e-13 48.6 0.0 2.9e-12 46.8 0.0 2.0 2 0 0 2 2 2 1 PCI domain RPN7 PF10602.4 EFX03392.1 - 0.055 12.8 0.5 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Sec23_trunk PF04811.10 EFX03393.1 - 2.4e-52 177.7 0.0 6.1e-52 176.3 0.0 1.6 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EFX03393.1 - 5.6e-22 77.1 0.0 9.5e-22 76.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EFX03393.1 - 1.6e-18 67.0 0.0 2.8e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EFX03393.1 - 3.2e-15 55.3 4.2 6.7e-15 54.3 2.9 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EFX03393.1 - 4e-05 23.2 0.0 7.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-H2C2_2 PF13465.1 EFX03394.1 - 1.3e-22 78.9 26.7 2.8e-07 30.4 0.6 5.3 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.21 EFX03394.1 - 4.7e-22 76.9 28.2 1e-05 25.5 1.2 5.1 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX03394.1 - 4.2e-16 58.0 23.6 0.00026 21.1 2.6 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EFX03394.1 - 1.7e-05 24.5 13.0 0.47 10.4 0.3 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFX03394.1 - 4.1e-05 23.6 6.1 1.4 9.1 0.0 4.8 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.1 EFX03394.1 - 0.02 14.5 8.3 1.1 9.0 0.1 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-met PF12874.2 EFX03394.1 - 0.025 14.7 14.3 1.6 9.0 0.0 4.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.5 EFX03394.1 - 0.051 13.5 9.5 5.6 7.0 0.9 3.7 3 1 0 3 3 3 0 Zinc ribbon domain C1_4 PF07975.7 EFX03394.1 - 0.13 12.3 0.5 17 5.5 0.0 2.8 2 1 1 3 3 3 0 TFIIH C1-like domain XPA_N PF01286.13 EFX03394.1 - 0.13 11.9 0.2 0.13 11.9 0.2 3.3 4 0 0 4 4 4 0 XPA protein N-terminal zf-TRAF PF02176.13 EFX03394.1 - 0.43 10.9 8.5 2.1 8.7 0.5 2.5 1 1 1 2 2 2 0 TRAF-type zinc finger C1_1 PF00130.17 EFX03394.1 - 0.96 9.2 4.4 1.4 8.7 0.8 2.3 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CBS PF00571.23 EFX03395.1 - 8.3e-42 140.7 6.9 5.7e-11 42.0 0.0 5.3 5 0 0 5 5 5 4 CBS domain PB1 PF00564.19 EFX03395.1 - 3.6e-08 32.9 0.9 6.3e-08 32.1 0.0 2.0 2 1 0 2 2 2 1 PB1 domain Apc1 PF12859.2 EFX03396.1 - 1.8e-19 69.8 0.7 1.3e-18 67.0 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 EFX03396.1 - 1.1e-06 28.5 0.0 0.011 15.9 0.0 4.1 3 0 0 3 3 3 2 Proteasome/cyclosome repeat SYS1 PF09801.4 EFX03397.1 - 4.6e-48 162.8 8.6 5.4e-48 162.6 5.9 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Transmemb_17 PF09799.4 EFX03397.1 - 0.14 12.5 8.7 0.28 11.5 4.4 2.1 1 1 1 2 2 2 0 Predicted membrane protein MFS_1 PF07690.11 EFX03398.1 - 1.1e-30 106.5 29.3 2.4e-30 105.4 20.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily XPG_I PF00867.13 EFX03398.1 - 6.2e-29 99.9 0.0 1.4e-28 98.7 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EFX03398.1 - 3.7e-18 65.6 0.0 1.1e-17 64.1 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 EFX03398.1 - 1.4e-05 25.2 0.3 4.6e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Fe_dep_repr_C PF02742.10 EFX03398.1 - 0.036 13.7 0.0 0.24 11.0 0.0 2.3 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain HXXSHH PF07586.6 EFX03398.1 - 1.4 7.7 4.4 2.2 7.1 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Ribosomal_S2 PF00318.15 EFX03399.1 - 5.8e-46 156.3 0.0 2.6e-45 154.2 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S2 Abhydrolase_6 PF12697.2 EFX03400.1 - 4.1e-28 98.8 5.3 1.3e-27 97.2 3.6 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX03400.1 - 8.7e-07 28.7 0.0 3.1e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX03400.1 - 1.2e-05 25.1 0.0 2.1e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EFX03400.1 - 0.034 13.5 0.0 0.07 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.9 EFX03400.1 - 0.063 11.7 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family DnaJ PF00226.26 EFX03401.1 - 1.1e-19 69.8 1.1 1.6e-19 69.3 0.2 1.7 2 0 0 2 2 2 1 DnaJ domain Gryzun PF07919.7 EFX03402.1 - 2.9e-76 256.9 0.0 3.9e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.3 EFX03402.1 - 4.4e-57 193.3 0.1 2.7e-54 184.2 0.0 2.3 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun-like PF12742.2 EFX03402.1 - 0.0018 18.0 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking KRAP_IP3R_bind PF14722.1 EFX03402.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Gti1_Pac2 PF09729.4 EFX03404.1 - 2.4e-48 164.1 1.2 2.4e-48 164.1 0.8 2.7 2 2 0 2 2 2 1 Gti1/Pac2 family F-actin_cap_A PF01267.12 EFX03405.1 - 3.6e-91 304.9 0.0 4.1e-91 304.7 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit GatB_N PF02934.10 EFX03406.1 - 3.2e-88 295.3 0.0 4.2e-88 294.9 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 EFX03406.1 - 0.00012 21.8 0.0 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 GatB domain Cucumo_coat PF00760.13 EFX03409.1 - 0.02 13.8 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 Cucumovirus coat protein CFEM PF05730.6 EFX03410.1 - 1.9e-07 30.7 8.6 3.4e-07 29.9 5.9 1.4 1 0 0 1 1 1 1 CFEM domain Ustilago_mating PF05722.7 EFX03410.1 - 0.0022 17.3 5.0 0.0022 17.3 3.5 1.8 2 0 0 2 2 2 1 Ustilago B locus mating-type protein DUF4658 PF15555.1 EFX03411.1 - 0.58 10.0 5.5 1.3 8.8 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4658) DUF4064 PF13273.1 EFX03412.1 - 1.6 8.8 6.5 12 6.1 4.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) HUN PF08729.5 EFX03413.1 - 1.4e-13 50.5 0.6 3e-13 49.4 0.4 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Cyt-b5 PF00173.23 EFX03414.1 - 4e-24 84.1 0.1 5.3e-24 83.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HemX PF04375.9 EFX03414.1 - 0.024 13.2 2.7 0.031 12.8 1.9 1.2 1 0 0 1 1 1 0 HemX p450 PF00067.17 EFX03415.1 - 1.7e-54 185.0 0.0 8.4e-54 182.8 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 TrbI PF03743.9 EFX03415.1 - 0.16 11.4 0.1 0.35 10.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein RPAP1_C PF08620.5 EFX03416.1 - 1.8e-29 101.3 0.0 5.3e-29 99.8 0.0 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 EFX03416.1 - 9.7e-14 50.6 4.4 1.8e-13 49.8 3.0 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal RXT2_N PF08595.6 EFX03417.1 - 4e-39 133.7 0.0 4e-39 133.7 0.0 2.4 3 0 0 3 3 3 1 RXT2-like, N-terminal TerB PF05099.8 EFX03417.1 - 0.026 14.2 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 Tellurite resistance protein TerB Tubulin PF00091.20 EFX03418.1 - 1.1e-72 244.3 0.0 2.6e-72 243.1 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFX03418.1 - 2.7e-48 163.1 0.1 4.7e-48 162.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 EFX03418.1 - 2.9e-06 27.3 0.0 6.6e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 EFX03418.1 - 0.00064 19.2 0.0 0.0013 18.2 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Methyltransf_23 PF13489.1 EFX03419.1 - 2.7e-18 66.1 0.0 4.1e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03419.1 - 6e-14 52.3 0.0 1.1e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03419.1 - 1.2e-08 35.5 0.0 2.5e-07 31.2 0.0 2.4 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03419.1 - 3.5e-08 33.8 0.0 3.7e-07 30.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03419.1 - 3.8e-08 33.0 0.0 1.1e-06 28.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX03419.1 - 4.9e-07 29.0 0.0 4.5e-06 25.9 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX03419.1 - 1e-05 25.8 0.0 2.9e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX03419.1 - 0.00017 21.0 0.0 0.0014 17.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.12 EFX03419.1 - 0.0011 18.0 0.0 0.003 16.6 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX03419.1 - 0.0064 16.5 0.0 0.018 15.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.7 EFX03419.1 - 0.013 14.8 0.1 0.027 13.7 0.0 1.5 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.4 EFX03419.1 - 0.035 13.5 0.0 0.098 12.1 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Sugar_tr PF00083.19 EFX03420.1 - 5e-14 51.7 1.5 7.1e-14 51.2 1.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03420.1 - 0.024 13.3 0.9 0.046 12.4 0.5 1.5 2 0 0 2 2 2 0 Major Facilitator Superfamily zf-RING_2 PF13639.1 EFX03421.1 - 3.1e-12 46.1 3.3 5.4e-12 45.3 2.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFX03421.1 - 9e-12 44.9 1.9 1.5e-11 44.2 1.3 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EFX03421.1 - 8.8e-07 28.6 0.8 1.7e-06 27.7 0.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 EFX03421.1 - 1.3e-05 24.8 2.6 2.1e-05 24.1 1.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFX03421.1 - 2.5e-05 24.2 4.8 7.1e-05 22.7 3.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX03421.1 - 4.2e-05 23.1 3.5 6.9e-05 22.4 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX03421.1 - 0.00012 21.7 1.4 0.0002 20.9 1.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFX03421.1 - 0.012 15.3 1.5 0.03 14.0 1.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.3 EFX03421.1 - 0.021 14.7 4.3 0.35 10.8 3.0 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.3 EFX03421.1 - 0.17 11.4 1.8 0.39 10.2 1.3 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DASH_Dam1 PF08653.5 EFX03422.1 - 1.8e-27 94.8 1.2 3.4e-27 93.9 0.8 1.5 1 0 0 1 1 1 1 DASH complex subunit Dam1 DUF167 PF02594.11 EFX03422.1 - 0.0066 16.3 0.1 0.05 13.5 0.0 2.1 1 1 1 2 2 2 1 Uncharacterised ACR, YggU family COG1872 DUF4470 PF14737.1 EFX03424.1 - 5.4e-15 54.9 0.0 1.2e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Terpene_synth_C PF03936.11 EFX03424.1 - 7e-09 35.2 0.0 1.6e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain Mqo PF06039.10 EFX03424.1 - 0.068 11.3 0.0 0.11 10.6 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) DUF2427 PF10348.4 EFX03425.1 - 0.0077 15.7 5.2 0.017 14.7 3.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) PPR_2 PF13041.1 EFX03426.1 - 0.011 15.6 0.0 3.8 7.5 0.0 2.8 2 0 0 2 2 2 0 PPR repeat family p450 PF00067.17 EFX03427.1 - 6.6e-67 226.0 0.0 8.5e-67 225.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Complex1_LYR PF05347.10 EFX03428.1 - 8.6e-09 35.0 0.0 1.6e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFX03428.1 - 9.9e-07 28.8 0.0 1.9e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 EFX03428.1 - 2.8e-05 24.5 0.1 4.4e-05 23.9 0.1 1.3 1 1 0 1 1 1 1 Complex1_LYR-like PMT_C PF11647.3 EFX03428.1 - 0.0073 15.8 0.0 0.58 9.8 0.0 2.2 2 0 0 2 2 2 1 C-terminal region of Pasteurella multocida toxin residues 569-1285 DUF77 PF01910.12 EFX03429.1 - 4.5e-31 106.3 0.4 5.1e-31 106.2 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF77 Med2 PF11214.3 EFX03429.1 - 0.0026 17.7 0.0 0.0033 17.4 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 2 Polysacc_deac_1 PF01522.16 EFX03429.1 - 0.018 14.6 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide deacetylase UQ_con PF00179.21 EFX03430.1 - 2e-36 124.5 0.0 2.7e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX03430.1 - 0.0046 16.7 0.0 0.0065 16.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B SLAC1 PF03595.12 EFX03431.1 - 3.1e-85 285.7 51.8 4.1e-85 285.3 35.9 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel Radical_SAM PF04055.16 EFX03431.1 - 8e-24 84.6 0.1 1.4e-23 83.8 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 EFX03431.1 - 1.3e-22 79.6 0.0 3e-22 78.5 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 EFX03431.1 - 1.5e-06 28.2 1.2 4.1e-06 26.8 0.1 2.3 2 1 0 2 2 2 1 Flavodoxin NDUF_B4 PF07225.7 EFX03432.1 - 0.029 14.1 0.1 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Methyltransf_23 PF13489.1 EFX03433.1 - 8.5e-14 51.5 0.0 1.1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03433.1 - 3.8e-08 33.8 0.3 3.9e-06 27.4 0.1 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03433.1 - 9.9e-08 32.3 0.0 1.7e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03433.1 - 3e-06 26.8 0.0 0.076 12.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03433.1 - 1.4e-05 25.4 0.0 5.2e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX03433.1 - 0.00011 22.5 0.1 0.0008 19.7 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX03433.1 - 0.00032 20.1 0.0 0.00099 18.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EFX03433.1 - 0.00044 20.2 0.6 0.0019 18.1 0.4 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX03433.1 - 0.0033 16.4 0.0 0.0072 15.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.14 EFX03433.1 - 0.02 14.4 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Mucin PF01456.12 EFX03434.1 - 0.052 13.3 5.8 0.059 13.1 4.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DNA_pol_E_B PF04042.11 EFX03435.1 - 7.2e-50 169.1 0.0 9.5e-50 168.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF367 PF04034.8 EFX03437.1 - 5.2e-46 155.3 0.0 7.7e-46 154.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 EFX03437.1 - 4.1e-12 45.4 1.2 8.8e-12 44.4 0.8 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Ammonium_transp PF00909.16 EFX03440.1 - 8.8e-115 383.3 25.6 1e-114 383.1 17.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF373 PF04123.8 EFX03440.1 - 0.16 10.9 0.2 0.36 9.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF373) SieB PF14163.1 EFX03440.1 - 0.63 9.6 4.7 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Superinfection exclusion protein B DUF2207 PF09972.4 EFX03440.1 - 9.6 4.6 6.3 12 4.3 0.7 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) MFS_1 PF07690.11 EFX03441.1 - 3.3e-31 108.2 30.6 3.3e-31 108.2 21.2 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily DASH_Dad3 PF08656.5 EFX03441.1 - 7.8e-26 89.5 0.3 1.3e-25 88.8 0.2 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad3 UNC-93 PF05978.11 EFX03441.1 - 0.00017 21.1 2.9 0.00046 19.7 2.0 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Sugarporin_N PF11471.3 EFX03441.1 - 4 7.1 6.3 0.36 10.4 0.2 2.4 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension Mpv17_PMP22 PF04117.7 EFX03442.1 - 1.9e-25 88.2 0.4 3.1e-25 87.5 0.3 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family IcmF-related PF06761.7 EFX03442.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Intracellular multiplication and human macrophage-killing adh_short PF00106.20 EFX03443.1 - 7.7e-25 87.7 3.2 1e-24 87.3 2.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX03443.1 - 2.1e-14 53.5 0.6 3e-14 53.0 0.4 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFX03443.1 - 3.1e-07 30.4 0.0 3.9e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 EFX03443.1 - 3.7e-05 22.7 0.1 4.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EFX03443.1 - 0.0017 17.8 0.5 0.0035 16.8 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 EFX03443.1 - 0.0087 15.8 0.2 0.022 14.5 0.2 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_7 PF13241.1 EFX03443.1 - 0.089 13.0 0.5 0.3 11.3 0.3 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding Glyco_tran_WecB PF03808.8 EFX03443.1 - 0.093 12.1 0.0 0.3 10.4 0.0 1.9 3 0 0 3 3 3 0 Glycosyl transferase WecB/TagA/CpsF family ZZ PF00569.12 EFX03444.1 - 9.8e-18 63.4 50.1 4.3e-06 26.1 2.2 4.5 4 0 0 4 4 4 4 Zinc finger, ZZ type Pkinase PF00069.20 EFX03445.1 - 5.4e-43 147.0 0.0 3e-42 144.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03445.1 - 3.6e-31 108.1 0.0 5.7e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pal1 PF08316.6 EFX03445.1 - 4.7e-09 36.8 0.0 1.2e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Pal1 cell morphology protein Kinase-like PF14531.1 EFX03445.1 - 0.0077 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX03445.1 - 0.03 13.4 0.0 0.067 12.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family fn3 PF00041.16 EFX03446.1 - 2.4e-10 40.4 0.2 8e-10 38.7 0.2 2.0 1 0 0 1 1 1 1 Fibronectin type III domain DUF812 PF05667.6 EFX03446.1 - 0.0011 17.6 25.7 0.0011 17.6 17.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF812) AAA_13 PF13166.1 EFX03446.1 - 0.48 8.8 31.0 0.96 7.8 21.5 1.4 1 0 0 1 1 1 0 AAA domain Csm1 PF12539.3 EFX03447.1 - 1.4e-23 83.1 0.0 2.3e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 DUF2062 PF09835.4 EFX03447.1 - 0.55 9.8 2.6 0.91 9.1 1.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Chal_sti_synt_N PF00195.14 EFX03448.1 - 1.1e-22 80.4 0.2 1.6e-22 79.8 0.1 1.1 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Chal_sti_synt_C PF02797.10 EFX03448.1 - 6.4e-22 78.1 0.0 1.6e-21 76.8 0.0 1.5 2 0 0 2 2 2 1 Chalcone and stilbene synthases, C-terminal domain FAE1_CUT1_RppA PF08392.7 EFX03448.1 - 4.3e-06 26.0 0.0 6.1e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.5 EFX03448.1 - 3.7e-05 23.6 0.0 0.0001 22.2 0.0 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.5 EFX03448.1 - 0.00048 19.7 0.2 0.0015 18.1 0.1 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UDG PF03167.14 EFX03449.1 - 1e-19 70.5 0.0 1.6e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Glyco_hydro_11 PF00457.12 EFX03450.1 - 5.2e-49 166.0 18.6 6.2e-49 165.8 12.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 SNARE PF05739.14 EFX03451.1 - 1.4e-14 53.4 2.0 4.5e-14 51.8 1.4 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.20 EFX03451.1 - 7.7e-09 35.6 5.1 7.7e-09 35.6 3.6 2.5 2 1 0 2 2 2 1 Syntaxin ETRAMP PF09716.5 EFX03451.1 - 0.005 16.7 0.0 0.0097 15.8 0.0 1.6 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) GlnD_UR_UTase PF08335.6 EFX03451.1 - 0.005 16.6 2.9 0.0095 15.7 2.0 1.4 1 0 0 1 1 1 1 GlnD PII-uridylyltransferase DUF4129 PF13559.1 EFX03451.1 - 0.013 15.4 5.5 0.075 13.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) PBP1_TM PF14812.1 EFX03451.1 - 0.018 15.3 0.0 0.018 15.3 0.0 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2315 PF10231.4 EFX03451.1 - 0.059 13.2 2.3 0.12 12.2 1.6 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) Herpes_US9 PF06072.6 EFX03451.1 - 0.1 12.4 0.3 0.2 11.4 0.2 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Syntaxin_2 PF14523.1 EFX03451.1 - 0.32 11.0 16.3 0.32 11.0 4.5 2.7 2 1 0 2 2 2 0 Syntaxin-like protein Synaptobrevin PF00957.16 EFX03451.1 - 0.37 10.4 2.4 0.23 11.0 0.2 1.8 2 0 0 2 2 2 0 Synaptobrevin BLOC1_2 PF10046.4 EFX03451.1 - 1.8 8.7 12.0 1.1 9.3 0.1 4.0 3 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.7 EFX03451.1 - 2.9 7.6 15.6 5 6.9 2.3 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Muted PF14942.1 EFX03451.1 - 4.3 7.2 10.2 3.4 7.5 2.5 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF342 PF03961.8 EFX03451.1 - 4.4 5.5 7.9 0.51 8.7 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF342) AAA PF00004.24 EFX03453.1 - 1.3e-38 132.1 0.0 2.6e-38 131.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFX03453.1 - 3.9e-06 26.9 4.9 7.1e-05 22.8 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 EFX03453.1 - 5.2e-06 26.3 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX03453.1 - 8.6e-06 25.9 0.7 0.00029 20.9 0.1 2.9 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.9 EFX03453.1 - 1.1e-05 25.1 0.1 0.00013 21.7 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EFX03453.1 - 1.3e-05 25.9 0.0 3.7e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EFX03453.1 - 1.7e-05 24.8 0.0 7.5e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EFX03453.1 - 2.6e-05 23.3 0.0 6.4e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 EFX03453.1 - 0.00038 19.9 0.6 0.00067 19.1 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_28 PF13521.1 EFX03453.1 - 0.0005 20.0 1.1 0.01 15.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFX03453.1 - 0.00056 19.3 0.5 0.026 13.9 0.1 2.6 1 1 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 EFX03453.1 - 0.0006 19.8 0.5 0.0013 18.7 0.0 1.9 2 0 0 2 2 1 1 Sigma-54 interaction domain RNA_helicase PF00910.17 EFX03453.1 - 0.00093 19.3 0.0 0.0034 17.5 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_33 PF13671.1 EFX03453.1 - 0.001 18.9 2.7 0.0017 18.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EFX03453.1 - 0.0014 17.8 1.3 0.0019 17.3 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.16 EFX03453.1 - 0.0014 17.8 1.8 0.0015 17.7 0.1 1.9 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.7 EFX03453.1 - 0.0037 16.9 0.7 0.0091 15.6 0.0 2.0 2 1 0 2 2 1 1 NACHT domain AAA_18 PF13238.1 EFX03453.1 - 0.0039 17.4 0.0 0.012 15.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 EFX03453.1 - 0.0059 16.2 0.3 0.017 14.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 EFX03453.1 - 0.0082 15.6 0.0 0.023 14.1 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain ABC_tran PF00005.22 EFX03453.1 - 0.013 15.8 0.8 0.082 13.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter DUF815 PF05673.8 EFX03453.1 - 0.014 14.3 0.2 0.039 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_19 PF13245.1 EFX03453.1 - 0.017 14.8 0.1 0.017 14.8 0.1 2.5 3 0 0 3 3 2 0 Part of AAA domain AAA_10 PF12846.2 EFX03453.1 - 0.024 14.0 0.5 1.9 7.8 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain Rad17 PF03215.10 EFX03453.1 - 0.027 13.1 0.0 0.058 12.0 0.0 1.6 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Parvo_NS1 PF01057.12 EFX03453.1 - 0.03 13.1 0.0 0.064 12.1 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 EFX03453.1 - 0.06 13.0 0.0 0.27 10.9 0.0 1.8 1 1 1 2 2 2 0 Archaeal ATPase Oxidored_nitro PF00148.14 EFX03453.1 - 0.071 11.7 0.0 0.22 10.0 0.0 1.7 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase UPF0079 PF02367.12 EFX03453.1 - 0.089 12.4 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Viral_helicase1 PF01443.13 EFX03453.1 - 0.09 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.9 EFX03453.1 - 0.094 11.6 0.4 0.66 8.9 0.0 2.3 2 1 1 3 3 3 0 KAP family P-loop domain TIP49 PF06068.8 EFX03453.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus KaiC PF06745.8 EFX03453.1 - 0.12 11.4 0.1 0.7 8.9 0.0 2.1 2 1 1 3 3 2 0 KaiC Guanylate_kin PF00625.16 EFX03453.1 - 0.15 11.5 3.7 0.34 10.3 0.0 3.1 3 1 0 3 3 3 0 Guanylate kinase DUF2360 PF10152.4 EFX03453.1 - 0.38 11.0 5.2 0.76 10.0 3.6 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) SUZ PF12752.2 EFX03454.1 - 1.8e-05 25.1 6.2 1.8e-05 25.1 4.3 3.5 4 0 0 4 4 4 1 SUZ domain YhzD PF14120.1 EFX03454.1 - 1.8 8.5 5.9 0.75 9.7 0.1 2.2 2 0 0 2 2 2 0 YhzD-like protein WD40 PF00400.27 EFX03455.1 - 6.8e-45 149.4 12.4 2.2e-11 43.1 0.1 6.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 EFX03455.1 - 4.5e-06 25.0 3.3 0.83 7.7 0.1 4.1 3 1 1 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFX03455.1 - 6e-05 21.9 0.0 0.22 10.2 0.0 3.1 1 1 1 3 3 3 2 Nup133 N terminal like TRAM_LAG1_CLN8 PF03798.11 EFX03456.1 - 1.6e-33 115.9 15.7 1.6e-33 115.9 10.9 1.5 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 EFX03456.1 - 4.2e-18 64.6 0.0 1.5e-17 62.8 0.0 2.0 2 0 0 2 2 2 1 TRAM1-like protein DUF3609 PF12259.3 EFX03457.1 - 0.0026 16.5 0.0 0.0027 16.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3609) DUF2269 PF10027.4 EFX03457.1 - 0.0035 17.1 0.1 0.0042 16.8 0.1 1.0 1 0 0 1 1 1 1 Predicted integral membrane protein (DUF2269) PgaD PF13994.1 EFX03457.1 - 0.01 15.3 0.0 0.011 15.2 0.0 1.0 1 0 0 1 1 1 1 PgaD-like protein SIT PF15330.1 EFX03457.1 - 0.021 14.9 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT SieB PF14163.1 EFX03457.1 - 0.033 13.7 0.1 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 Superinfection exclusion protein B ODV-E18 PF10717.4 EFX03457.1 - 0.041 13.3 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 OAD_gamma PF04277.8 EFX03457.1 - 0.051 13.9 0.2 0.079 13.3 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PspB PF06667.7 EFX03457.1 - 0.068 13.1 0.5 0.09 12.7 0.4 1.2 1 0 0 1 1 1 0 Phage shock protein B Vpu PF00558.14 EFX03457.1 - 0.072 12.6 0.4 0.095 12.2 0.3 1.2 1 0 0 1 1 1 0 Vpu protein DUF1206 PF06724.6 EFX03457.1 - 0.087 12.5 0.2 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) SpoIIIAH PF12685.2 EFX03457.1 - 0.11 12.0 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein ATP-synt_8 PF00895.15 EFX03457.1 - 0.11 12.7 0.5 0.16 12.1 0.3 1.2 1 0 0 1 1 1 0 ATP synthase protein 8 BatA PF07584.6 EFX03457.1 - 0.14 12.3 1.5 0.61 10.3 1.0 1.8 1 1 1 2 2 2 0 Aerotolerance regulator N-terminal Renin_r PF07850.9 EFX03457.1 - 0.15 12.4 0.6 0.18 12.1 0.4 1.1 1 0 0 1 1 1 0 Renin receptor-like protein Lactamase_B PF00753.22 EFX03459.1 - 2.8e-05 23.8 1.0 5.1e-05 23.0 0.6 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFX03459.1 - 0.004 16.7 0.1 0.0051 16.3 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PCI PF01399.22 EFX03460.1 - 0.00057 20.1 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 2 PCI domain TPR_2 PF07719.12 EFX03460.1 - 0.097 12.6 0.2 0.29 11.1 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat AA_permease_2 PF13520.1 EFX03461.1 - 6.7e-49 166.5 58.8 8.1e-49 166.2 40.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX03461.1 - 2.4e-24 85.5 50.5 3.1e-24 85.1 35.0 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2463 PF09591.5 EFX03461.1 - 0.1 12.2 11.8 0.8 9.2 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2463) DUF3638 PF12340.3 EFX03462.1 - 1.7e-94 315.1 0.2 3.9e-94 313.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 EFX03462.1 - 1.2e-17 62.7 0.7 2.5e-17 61.6 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) GUCT PF08152.7 EFX03462.1 - 0.055 13.4 0.1 2.5 8.1 0.0 3.5 4 0 0 4 4 4 0 GUCT (NUC152) domain Zn_clus PF00172.13 EFX03463.1 - 1e-05 25.2 14.0 1.7e-05 24.6 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF294 PF03445.8 EFX03463.1 - 0.036 13.6 0.7 0.085 12.4 0.5 1.5 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 MARVEL PF01284.18 EFX03464.1 - 3.7e-05 23.5 12.0 0.00084 19.1 7.8 2.1 1 1 1 2 2 2 2 Membrane-associating domain SPA PF08616.5 EFX03464.1 - 0.15 11.7 0.7 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 Stabilization of polarity axis Methyltransf_16 PF10294.4 EFX03465.1 - 9.5e-11 41.4 0.2 0.0061 16.0 0.0 3.2 2 1 1 3 3 3 3 Putative methyltransferase Innate_immun PF12782.2 EFX03465.1 - 6.7 5.8 7.8 10 5.2 5.4 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family MIT PF04212.13 EFX03468.1 - 6.4e-08 32.3 1.4 1.3e-07 31.3 0.9 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain zf-CCCH PF00642.19 EFX03469.1 - 2.6e-06 26.9 9.6 3e-05 23.5 1.3 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EFX03469.1 - 1.2 9.2 17.5 0.2 11.7 0.4 3.2 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type adh_short PF00106.20 EFX03470.1 - 5.5e-21 75.2 0.2 1.1e-20 74.1 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFX03470.1 - 6e-13 48.8 0.5 1.4e-12 47.6 0.0 1.7 2 1 1 3 3 3 1 KR domain Epimerase PF01370.16 EFX03470.1 - 8.4e-07 28.6 0.0 2.2e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFX03470.1 - 3.9e-06 25.9 0.0 5.2e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 EFX03470.1 - 0.0019 17.9 1.4 0.0041 16.8 0.9 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PS-DH PF14765.1 EFX03470.1 - 0.0078 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase NAD_binding_10 PF13460.1 EFX03470.1 - 0.18 11.7 0.6 0.32 10.9 0.4 1.7 1 1 0 1 1 1 0 NADH(P)-binding Fungal_trans PF04082.13 EFX03471.1 - 5.5e-12 45.1 0.0 8.3e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03471.1 - 6.6e-06 25.9 7.2 1.3e-05 25.0 5.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Barwin PF00967.12 EFX03472.1 - 0.38 10.4 3.3 0.28 10.8 0.3 2.1 2 1 0 2 2 2 0 Barwin family Peptidase_M28 PF04389.12 EFX03474.1 - 1.6e-33 115.9 0.0 2.6e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFX03474.1 - 2.3e-15 56.1 0.3 5.7e-15 54.8 0.2 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 EFX03474.1 - 0.0018 17.7 0.0 0.004 16.6 0.0 1.7 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_S15 PF02129.13 EFX03475.1 - 2.7e-39 135.2 0.5 3.7e-39 134.8 0.4 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 EFX03475.1 - 8.2e-39 133.7 0.1 1.3e-38 133.0 0.1 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_6 PF12697.2 EFX03475.1 - 6.6e-06 26.1 1.0 6.6e-06 26.1 0.7 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX03475.1 - 0.00019 21.1 0.2 0.00064 19.4 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EFX03475.1 - 0.03 14.1 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase IN_DBD_C PF00552.16 EFX03475.1 - 0.055 12.9 0.1 0.27 10.7 0.0 2.1 2 0 0 2 2 2 0 Integrase DNA binding domain Ank_2 PF12796.2 EFX03477.1 - 6.3e-89 292.4 20.1 8.4e-14 51.6 0.0 9.6 3 3 8 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX03477.1 - 8.2e-70 230.0 19.9 6.1e-09 36.1 0.0 13.2 5 4 8 13 13 13 13 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX03477.1 - 6.5e-65 213.6 22.4 1.4e-06 28.2 0.1 13.6 6 3 8 15 15 15 13 Ankyrin repeats (many copies) Ank PF00023.25 EFX03477.1 - 4.6e-59 193.4 24.1 1.2e-06 28.0 0.1 17.2 17 0 0 17 17 17 14 Ankyrin repeat Ank_3 PF13606.1 EFX03477.1 - 2.1e-49 160.5 14.6 0.0025 17.9 0.0 15.7 15 0 0 15 15 15 11 Ankyrin repeat HET PF06985.6 EFX03477.1 - 1e-18 67.8 0.0 6.1e-18 65.3 0.0 2.4 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) SchA_CurD PF04486.7 EFX03477.1 - 0.13 12.1 2.1 34 4.2 0.0 4.6 5 1 1 6 6 6 0 SchA/CurD like domain DUF2953 PF11167.3 EFX03477.1 - 0.19 11.6 0.0 0.47 10.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) zf-C2H2 PF00096.21 EFX03478.1 - 2e-05 24.6 11.3 0.0019 18.4 2.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX03478.1 - 0.0057 16.9 14.3 0.038 14.3 1.5 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger PSI_PsaH PF03244.9 EFX03478.1 - 0.043 13.0 0.3 0.098 11.8 0.2 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI zf-H2C2_2 PF13465.1 EFX03478.1 - 2.7 8.4 12.6 1.6 9.2 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger double domain p450 PF00067.17 EFX03479.1 - 8.6e-64 215.7 0.0 5e-50 170.3 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 FAD_binding_3 PF01494.14 EFX03480.1 - 7.7e-25 87.6 0.1 2.9e-11 43.0 0.2 2.1 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EFX03480.1 - 0.0034 16.3 1.8 0.035 13.0 0.1 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 EFX03480.1 - 0.0085 15.8 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding SE PF08491.5 EFX03480.1 - 0.013 14.3 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox_2 PF07992.9 EFX03480.1 - 0.036 13.9 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX03480.1 - 0.16 10.8 0.0 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Asparaginase PF00710.15 EFX03481.1 - 5.9e-72 242.1 0.7 6.9e-72 241.9 0.5 1.0 1 0 0 1 1 1 1 Asparaginase NACHT PF05729.7 EFX03482.1 - 1e-06 28.5 0.0 2.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.2 EFX03482.1 - 2.2e-06 27.9 0.0 0.00012 22.3 0.0 2.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) AAA_22 PF13401.1 EFX03482.1 - 6.8e-05 23.0 0.0 0.00083 19.4 0.0 2.8 3 0 0 3 3 3 1 AAA domain Ank PF00023.25 EFX03482.1 - 0.00059 19.5 0.1 0.052 13.3 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat DUF676 PF05057.9 EFX03482.1 - 0.0032 16.7 0.0 0.015 14.5 0.0 2.0 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Ank_3 PF13606.1 EFX03482.1 - 0.004 17.2 0.0 2.1 8.8 0.0 3.4 2 0 0 2 2 2 1 Ankyrin repeat PGAP1 PF07819.8 EFX03482.1 - 0.011 15.3 0.0 0.028 13.9 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein Viral_helicase1 PF01443.13 EFX03482.1 - 0.017 14.6 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Abhydrolase_6 PF12697.2 EFX03482.1 - 0.021 14.7 0.0 0.046 13.5 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family RNA_helicase PF00910.17 EFX03482.1 - 0.026 14.6 0.0 0.35 11.0 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA PF00004.24 EFX03482.1 - 0.029 14.5 0.0 0.32 11.2 0.0 2.7 3 1 0 3 3 1 0 ATPase family associated with various cellular activities (AAA) Ank_4 PF13637.1 EFX03482.1 - 0.039 14.4 0.0 1.3 9.5 0.0 2.9 2 1 0 2 2 2 0 Ankyrin repeats (many copies) Arch_ATPase PF01637.13 EFX03482.1 - 0.043 13.5 0.0 0.13 11.9 0.0 1.9 1 1 0 1 1 1 0 Archaeal ATPase NB-ARC PF00931.17 EFX03482.1 - 0.066 12.0 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_10 PF12846.2 EFX03482.1 - 0.07 12.5 0.0 0.24 10.7 0.0 2.0 1 0 0 1 1 1 0 AAA-like domain AAA_17 PF13207.1 EFX03482.1 - 0.079 13.7 0.1 0.45 11.3 0.0 2.4 3 0 0 3 3 1 0 AAA domain ABC_tran PF00005.22 EFX03482.1 - 0.11 12.8 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.18 EFX03482.1 - 0.12 12.3 0.0 0.35 10.8 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.14 EFX03482.1 - 0.14 11.6 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 EFX03482.1 - 0.14 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 EFX03482.1 - 0.16 11.7 0.0 0.41 10.4 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain DP PF08781.5 EFX03482.1 - 0.16 11.6 0.5 0.28 10.8 0.3 1.3 1 0 0 1 1 1 0 Transcription factor DP AAA_23 PF13476.1 EFX03482.1 - 4.9 7.4 4.2 2.2 8.5 0.2 2.1 1 1 1 2 2 2 0 AAA domain Sugar_tr PF00083.19 EFX03483.1 - 5.2e-95 318.6 16.1 6.2e-95 318.4 11.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03483.1 - 6.7e-17 61.2 24.7 6.7e-17 61.2 17.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily YL1_C PF08265.6 EFX03483.1 - 2e-15 56.0 0.2 3.9e-15 55.0 0.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Cwf_Cwc_15 PF04889.7 EFX03484.1 - 5.7e-68 229.2 15.1 2.6e-42 145.2 7.1 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein DUF2890 PF11081.3 EFX03484.1 - 0.092 12.7 4.9 0.12 12.4 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) SHR3_chaperone PF08229.6 EFX03486.1 - 3.4e-61 205.6 0.2 4.1e-61 205.3 0.1 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Cbl_N3 PF02762.9 EFX03487.1 - 0.0073 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Mit_KHE1 PF10173.4 EFX03489.1 - 1e-56 191.7 0.0 1.8e-56 190.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related Polysacc_deac_1 PF01522.16 EFX03490.1 - 8.3e-13 48.0 0.0 1.4e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.4 EFX03490.1 - 7.2e-07 28.8 0.0 1.1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.4 EFX03490.1 - 0.079 10.9 0.0 0.14 10.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2194) UCH_1 PF13423.1 EFX03491.1 - 1.9e-52 178.5 0.3 3.6e-52 177.6 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 EFX03491.1 - 3e-25 89.4 0.0 5.7e-25 88.5 0.0 1.5 1 0 0 1 1 1 1 Exonuclease UCH PF00443.24 EFX03491.1 - 2.4e-07 30.1 0.0 2e-06 27.1 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pterin_4a PF01329.14 EFX03492.1 - 0.033 13.9 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase GTP_EFTU_D3 PF03143.12 EFX03492.1 - 0.076 13.1 0.1 0.27 11.4 0.0 1.7 1 1 0 2 2 2 0 Elongation factor Tu C-terminal domain Striatin PF08232.7 EFX03493.1 - 3.3 8.0 10.3 0.41 10.9 2.4 2.5 2 0 0 2 2 2 0 Striatin family AAA_17 PF13207.1 EFX03494.1 - 6.2e-06 27.0 0.2 0.00059 20.6 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.1 EFX03494.1 - 0.00015 21.7 0.4 0.0006 19.7 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX03494.1 - 0.00084 19.4 0.0 0.0099 16.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX03494.1 - 0.0011 19.2 0.2 0.003 17.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 EFX03494.1 - 0.0014 17.5 0.0 0.0018 17.1 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.7 EFX03494.1 - 0.0019 17.3 0.0 0.0034 16.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_19 PF13245.1 EFX03494.1 - 0.0029 17.3 0.7 0.011 15.5 0.1 2.3 2 1 0 2 2 2 1 Part of AAA domain Sulfotransfer_3 PF13469.1 EFX03494.1 - 0.0042 18.0 0.8 0.0054 17.6 0.6 1.1 1 0 0 1 1 1 1 Sulfotransferase family AAA_16 PF13191.1 EFX03494.1 - 0.0073 16.3 0.4 0.071 13.0 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 EFX03494.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain T2SE PF00437.15 EFX03494.1 - 0.018 13.9 0.0 0.028 13.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein PRK PF00485.13 EFX03494.1 - 0.02 14.4 0.0 0.054 13.0 0.0 1.6 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family cobW PF02492.14 EFX03494.1 - 0.04 13.3 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 EFX03494.1 - 0.077 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Fungal_trans PF04082.13 EFX03495.1 - 9.7e-16 57.4 0.4 1.7e-15 56.6 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03495.1 - 3e-07 30.2 7.3 4.9e-07 29.5 5.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rod_cone_degen PF15201.1 EFX03495.1 - 0.11 12.3 1.9 1.8 8.4 0.0 3.6 3 0 0 3 3 3 0 Progressive rod-cone degeneration Fork_head PF00250.13 EFX03496.1 - 5e-11 42.4 0.0 1.1e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EFX03496.1 - 9.8e-05 22.4 0.1 0.00023 21.1 0.0 1.6 1 0 0 1 1 1 1 FHA domain F-box-like PF12937.2 EFX03497.1 - 0.00025 20.7 0.1 0.00074 19.1 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX03497.1 - 0.0013 18.2 0.1 0.0039 16.7 0.0 1.9 1 1 0 1 1 1 1 F-box domain ThiF PF00899.16 EFX03498.1 - 3.2e-39 133.8 0.3 4.8e-39 133.3 0.2 1.3 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.5 EFX03498.1 - 9.6e-28 95.7 0.0 2.2e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 E2 binding domain UBACT PF02134.16 EFX03498.1 - 2.8e-22 78.0 0.2 5e-22 77.2 0.1 1.4 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 EFX03498.1 - 2.7e-15 55.4 1.8 2.7e-15 55.4 1.3 1.7 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 EFX03498.1 - 0.00023 21.2 0.0 0.0005 20.1 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UAE_UbL PF14732.1 EFX03498.1 - 0.0016 18.5 0.0 0.0066 16.5 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Ecm33 PF12454.3 EFX03498.1 - 0.025 14.4 1.4 0.052 13.4 0.9 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein MoeZ_MoeB PF05237.8 EFX03498.1 - 0.091 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 MoeZ/MoeB domain DAO PF01266.19 EFX03499.1 - 9.7e-50 169.4 2.7 1.1e-49 169.2 1.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX03499.1 - 9.1e-08 32.0 0.1 2.9e-07 30.4 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFX03499.1 - 4.3e-07 30.0 0.1 0.0012 18.7 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX03499.1 - 8.6e-06 25.9 0.1 0.0015 18.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX03499.1 - 4.4e-05 22.5 2.0 0.00031 19.7 0.4 2.3 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 EFX03499.1 - 6e-05 22.0 0.1 0.026 13.3 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.12 EFX03499.1 - 0.00014 21.0 0.0 0.00025 20.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 EFX03499.1 - 0.00038 20.8 0.1 0.0028 18.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 EFX03499.1 - 0.00051 19.2 0.6 0.27 10.2 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.1 EFX03499.1 - 0.0039 16.9 0.4 0.31 10.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding ThiF PF00899.16 EFX03499.1 - 0.0049 16.7 0.2 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.14 EFX03499.1 - 0.0066 15.5 0.0 0.01 14.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EFX03499.1 - 0.0084 14.6 0.6 0.14 10.5 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Trp_halogenase PF04820.9 EFX03499.1 - 0.01 14.5 0.5 0.019 13.6 0.1 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Ornatin PF02088.10 EFX03499.1 - 0.017 14.6 0.0 0.043 13.3 0.0 1.6 1 0 0 1 1 1 0 Ornatin NAD_binding_7 PF13241.1 EFX03499.1 - 0.019 15.1 0.0 0.043 14.0 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.15 EFX03499.1 - 0.025 14.6 0.1 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 EFX03499.1 - 0.073 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.2 EFX03499.1 - 0.084 11.9 0.2 0.14 11.1 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase SecY PF00344.15 EFX03501.1 - 1.8e-96 323.1 9.6 2.3e-96 322.7 6.6 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 EFX03501.1 - 8e-19 66.8 0.7 8.7e-18 63.5 0.3 2.6 2 0 0 2 2 2 1 Plug domain of Sec61p Pkinase PF00069.20 EFX03504.1 - 1.4e-32 112.9 0.0 2e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03504.1 - 4.1e-16 58.8 0.0 5.6e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FAD_binding_4 PF01565.18 EFX03505.1 - 6.1e-26 90.5 0.0 1e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain CPL PF08144.6 EFX03506.1 - 8.2e-21 74.3 4.9 3.5e-19 69.1 0.0 3.2 2 1 0 2 2 2 1 CPL (NUC119) domain Glyco_hydro_16 PF00722.16 EFX03507.1 - 1.8e-12 46.9 0.2 4.5e-12 45.6 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 VirB8 PF04335.8 EFX03507.1 - 4.4 6.8 5.5 0.58 9.6 0.2 1.9 1 1 1 2 2 2 0 VirB8 protein Methyltransf_23 PF13489.1 EFX03509.1 - 1.2e-22 80.3 0.0 1.7e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03509.1 - 8.1e-12 44.9 0.0 6e-11 42.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03509.1 - 2e-09 38.0 0.0 2.1e-08 34.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03509.1 - 2.7e-07 30.9 0.0 4.7e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03509.1 - 1.6e-06 28.5 0.0 9.2e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFX03509.1 - 0.00071 19.0 0.0 0.0016 17.9 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX03509.1 - 0.0072 16.3 0.0 0.034 14.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX03509.1 - 0.011 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.9 EFX03509.1 - 0.011 15.0 0.0 0.033 13.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.8 EFX03509.1 - 0.015 14.3 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 EFX03509.1 - 0.026 14.8 0.0 0.069 13.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EFX03509.1 - 0.028 13.4 0.0 0.15 11.1 0.0 2.0 2 1 0 2 2 2 0 Putative methyltransferase Response_reg PF00072.19 EFX03510.1 - 1.2e-28 99.3 0.3 2.2e-28 98.4 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 EFX03510.1 - 2.5e-28 97.9 0.0 8.2e-28 96.3 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EFX03510.1 - 2.7e-13 49.6 0.0 5.8e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EFX03510.1 - 0.0011 19.0 0.9 0.66 10.1 0.0 4.0 4 0 0 4 4 4 1 HAMP domain B56 PF01603.15 EFX03511.1 - 1.6e-174 580.3 4.4 2e-174 579.9 3.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Dynamin_N PF00350.18 EFX03511.1 - 0.045 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Dynamin family Nup160 PF11715.3 EFX03513.1 - 1.4e-121 406.3 0.0 2e-121 405.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_7 PF13176.1 EFX03513.1 - 0.045 13.5 1.4 0.15 11.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-AD PF07776.10 EFX03513.1 - 0.062 13.3 0.1 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) HSCB_C PF07743.8 EFX03514.1 - 0.011 16.2 0.4 4.8 7.7 0.1 3.3 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain MutS_III PF05192.13 EFX03514.1 - 0.018 14.8 0.3 0.033 13.9 0.2 1.4 1 0 0 1 1 1 0 MutS domain III DUF3375 PF11855.3 EFX03514.1 - 0.069 11.8 2.4 0.22 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) Aa_trans PF01490.13 EFX03515.1 - 4e-27 94.7 29.3 1.2e-16 60.2 4.3 2.0 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein HgmA PF04209.8 EFX03517.1 - 1.9e-130 435.0 0.0 2.4e-130 434.7 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase MMgT PF10270.4 EFX03518.1 - 0.028 14.8 0.8 0.12 12.8 0.0 2.2 2 1 1 3 3 3 0 Membrane magnesium transporter DUF4064 PF13273.1 EFX03518.1 - 0.053 13.6 0.3 0.4 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) ATP-synt_C PF00137.16 EFX03518.1 - 7.1 6.6 10.6 1.6 8.7 4.1 2.2 2 1 0 2 2 2 0 ATP synthase subunit C Methyltransf_23 PF13489.1 EFX03519.1 - 1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain STT3 PF02516.9 EFX03520.1 - 8.4e-128 427.3 41.3 1e-122 410.6 27.5 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Het-C PF07217.6 EFX03521.1 - 7.8e-287 952.4 0.0 9.9e-287 952.1 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Ribosomal_L37 PF08561.5 EFX03522.1 - 1.7e-29 101.2 1.6 6e-28 96.2 1.1 2.1 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 CAP_N PF01213.14 EFX03522.1 - 0.095 11.9 3.2 0.13 11.4 2.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.6 EFX03522.1 - 0.76 9.0 4.3 1.3 8.2 3.0 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator LIP PF03583.9 EFX03523.1 - 1.3e-77 260.8 0.4 1.8e-77 260.4 0.3 1.1 1 0 0 1 1 1 1 Secretory lipase Sina PF03145.11 EFX03524.1 - 0.014 15.1 0.1 0.014 15.1 0.1 2.0 2 0 0 2 2 2 0 Seven in absentia protein family zf-C2H2_4 PF13894.1 EFX03524.1 - 0.46 10.9 11.3 3.4 8.2 0.1 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger Histidinol_dh PF00815.15 EFX03525.1 - 6.4e-114 380.7 0.0 7.8e-114 380.5 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase HlyIII PF03006.15 EFX03526.1 - 4.3e-55 186.5 21.1 5.3e-55 186.2 14.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related MRVI1 PF05781.7 EFX03526.1 - 0.021 13.2 0.1 0.032 12.6 0.0 1.2 1 0 0 1 1 1 0 MRVI1 protein BCDHK_Adom3 PF10436.4 EFX03527.1 - 6.6e-38 129.7 0.0 9.1e-38 129.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EFX03527.1 - 2.6e-16 59.3 0.0 6.8e-15 54.7 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Inhibitor_I9 PF05922.11 EFX03527.1 - 3.3e-10 40.3 0.0 8.4e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 HATPase_c_3 PF13589.1 EFX03527.1 - 0.16 11.6 0.0 0.42 10.2 0.0 1.7 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_fiss_reg PF05308.6 EFX03527.1 - 1.3 8.2 7.0 3 7.1 4.8 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator NAD_binding_5 PF07994.7 EFX03529.1 - 4.1e-109 364.6 0.0 4.8e-109 364.4 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 EFX03529.1 - 2.5e-45 152.8 0.1 4.3e-45 152.1 0.1 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase AAA_23 PF13476.1 EFX03530.1 - 4.7e-14 53.1 8.8 7.1e-11 42.8 6.1 2.7 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 EFX03530.1 - 1.9e-09 37.0 0.0 5.6e-08 32.2 0.0 2.8 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Metallophos_2 PF12850.2 EFX03530.1 - 5.8e-07 29.4 2.4 7e-07 29.2 0.3 2.2 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EFX03530.1 - 1.3e-06 27.9 0.1 3.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_15 PF13175.1 EFX03530.1 - 3.9e-06 26.1 0.0 1e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.1 EFX03530.1 - 9.3e-06 25.8 0.0 0.0064 16.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX03530.1 - 3e-05 23.4 0.0 8.5e-05 22.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain DLD PF14878.1 EFX03530.1 - 0.034 14.2 3.1 0.097 12.7 1.6 2.3 2 0 0 2 2 2 0 Death-like domain of SPT6 ABC_tran PF00005.22 EFX03530.1 - 0.041 14.1 0.0 0.041 14.1 0.0 3.0 3 1 0 3 3 3 0 ABC transporter tRNA-synt_1b PF00579.20 EFX03531.1 - 3e-76 256.3 0.0 4.1e-76 255.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Zn_clus PF00172.13 EFX03532.1 - 2.3e-09 37.0 9.9 4e-09 36.2 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX03532.1 - 4.4e-09 35.5 0.0 6.5e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.19 EFX03533.1 - 1.8e-37 129.0 20.2 2.6e-37 128.4 14.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03533.1 - 4.4e-31 107.8 22.9 3e-24 85.3 6.0 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily CIAPIN1 PF05093.8 EFX03534.1 - 6.8e-34 115.9 3.8 1.2e-33 115.1 2.7 1.4 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Hom_end PF05204.9 EFX03534.1 - 0.074 13.0 0.1 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Homing endonuclease Vps55 PF04133.9 EFX03535.1 - 2.2e-46 156.4 5.2 2.4e-46 156.3 3.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Fip1 PF05182.8 EFX03536.1 - 5.3e-21 73.6 1.0 9.3e-21 72.8 0.7 1.3 1 0 0 1 1 1 1 Fip1 motif Aldedh PF00171.17 EFX03537.1 - 4.8e-142 473.5 0.0 6.4e-142 473.1 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EFX03537.1 - 1.5e-05 23.9 0.0 2.9e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Kdo PF06293.9 EFX03538.1 - 1.1e-12 47.5 0.0 1.5e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX03538.1 - 1.7e-10 41.0 4.7 4.3e-05 23.3 0.5 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.20 EFX03538.1 - 2.2e-09 36.8 0.0 3.4e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03538.1 - 6.2e-06 25.4 0.0 8.6e-06 25.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.15 EFX03538.1 - 0.013 14.7 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase RIO1 PF01163.17 EFX03538.1 - 0.042 13.1 0.0 0.69 9.2 0.0 2.3 2 0 0 2 2 2 0 RIO1 family WD40 PF00400.27 EFX03540.1 - 4e-15 55.0 4.8 7e-05 22.5 0.2 5.6 5 1 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.3 EFX03540.1 - 0.058 11.5 0.5 0.16 10.0 0.2 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SKG6 PF08693.5 EFX03541.1 - 0.021 14.0 1.8 0.021 14.0 1.3 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain EphA2_TM PF14575.1 EFX03541.1 - 0.13 12.6 0.0 2.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.1 EFX03541.1 - 0.18 11.9 0.0 0.18 11.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) PRP1_N PF06424.7 EFX03542.1 - 1.2e-44 151.8 4.6 2.8e-44 150.6 3.2 1.6 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_19 PF14559.1 EFX03542.1 - 8.9e-32 109.2 23.9 1.3e-07 31.8 0.0 9.4 6 2 3 9 9 9 9 Tetratricopeptide repeat TPR_14 PF13428.1 EFX03542.1 - 6.2e-28 94.7 61.6 2.2e-05 24.6 0.3 14.8 5 5 11 16 16 15 12 Tetratricopeptide repeat TPR_16 PF13432.1 EFX03542.1 - 7.2e-26 90.2 54.0 2e-06 28.3 1.4 9.4 8 1 3 11 11 10 8 Tetratricopeptide repeat TPR_2 PF07719.12 EFX03542.1 - 4.3e-11 41.8 19.0 0.039 13.8 0.0 10.9 12 1 1 13 13 13 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX03542.1 - 9.9e-11 41.1 20.3 0.039 13.6 0.0 8.7 5 3 6 11 11 11 5 TPR repeat TPR_17 PF13431.1 EFX03542.1 - 6.6e-10 38.3 4.3 3.1 8.2 0.0 9.5 9 1 1 10 10 10 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX03542.1 - 0.00024 20.6 0.0 1.2 9.0 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 EFX03542.1 - 0.00029 19.9 33.2 0.088 11.8 0.3 7.2 3 2 4 8 8 8 4 Tetratricopeptide repeat NARP1 PF12569.3 EFX03542.1 - 0.0012 17.6 10.8 0.87 8.2 0.0 6.3 5 1 2 7 7 7 1 NMDA receptor-regulated protein 1 TPR_1 PF00515.23 EFX03542.1 - 0.0064 16.0 0.9 3.2 7.5 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.5 EFX03542.1 - 0.14 10.9 21.4 0.17 10.7 0.0 5.9 3 2 2 6 6 6 0 NRDE-2, necessary for RNA interference TPR_7 PF13176.1 EFX03542.1 - 0.28 11.0 8.6 16 5.5 0.0 6.4 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.1 EFX03542.1 - 1 9.2 19.1 0.53 10.1 0.7 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 EFX03542.1 - 1.7 8.6 23.7 1.2 9.1 0.0 7.4 6 2 2 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX03542.1 - 7.6 7.2 18.8 22 5.7 0.0 8.5 12 0 0 12 12 10 0 Tetratricopeptide repeat stn_TNFRSF12A PF12191.3 EFX03543.1 - 1.8 8.6 5.4 3.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain PhoD PF09423.5 EFX03544.1 - 2e-62 211.2 0.0 3e-62 210.6 0.0 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase BNR PF02012.15 EFX03545.1 - 1.2e-12 45.5 34.6 0.3 11.0 0.2 11.8 11 0 0 11 11 11 6 BNR/Asp-box repeat PSII_BNR PF14870.1 EFX03545.1 - 4.4e-06 25.9 1.0 0.042 12.8 0.0 5.0 5 2 1 6 6 6 2 Photosynthesis system II assembly factor YCF48 DUF2167 PF09935.4 EFX03545.1 - 0.012 14.4 0.0 0.18 10.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2167) Peptidase_C34 PF05413.6 EFX03545.1 - 0.6 10.1 2.1 15 5.6 0.3 2.7 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase Mcp5_PH PF12814.2 EFX03546.1 - 5.7e-47 158.6 0.0 1.5e-46 157.2 0.0 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology TPR_MLP1_2 PF07926.7 EFX03546.1 - 0.24 11.1 22.6 0.88 9.3 13.7 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.7 EFX03546.1 - 1.1 9.0 2.9 1.9 8.3 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Methyltransf_23 PF13489.1 EFX03548.1 - 3.8e-08 33.2 0.0 7e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03548.1 - 1.5e-06 28.5 0.0 3.1e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03548.1 - 2.3e-05 24.7 0.0 4.7e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03548.1 - 0.05 13.2 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain OCD_Mu_crystall PF02423.10 EFX03549.1 - 9.4e-13 47.6 0.0 2.5e-07 29.7 0.0 2.9 3 0 0 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family SNAPc19 PF15497.1 EFX03549.1 - 0.027 14.6 0.2 0.054 13.7 0.2 1.4 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 NPR2 PF06218.6 EFX03550.1 - 8.8e-108 360.7 0.0 1.3e-107 360.1 0.0 1.3 1 0 0 1 1 1 1 Nitrogen permease regulator 2 Gly-zipper_OmpA PF13436.1 EFX03550.1 - 0.43 10.2 7.6 0.17 11.5 0.6 2.5 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Init_tRNA_PT PF04179.7 EFX03551.1 - 0.09 11.6 0.0 0.095 11.5 0.0 1.1 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase Amidohydro_2 PF04909.9 EFX03552.1 - 1.8e-45 155.6 1.0 2.3e-45 155.2 0.7 1.2 1 0 0 1 1 1 1 Amidohydrolase Asparaginase PF00710.15 EFX03552.1 - 0.029 13.2 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Asparaginase TatD_DNase PF01026.16 EFX03552.1 - 0.12 11.5 0.0 0.3 10.2 0.0 1.6 2 0 0 2 2 2 0 TatD related DNase Sod_Fe_C PF02777.13 EFX03553.1 - 2.2e-14 53.1 0.0 2.9e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EFX03553.1 - 0.0027 17.9 0.0 0.0044 17.2 0.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Pkinase_C PF00433.19 EFX03554.1 - 0.04 14.4 0.8 0.17 12.4 0.6 2.3 1 1 0 1 1 1 0 Protein kinase C terminal domain GAGE PF05831.6 EFX03555.1 - 0.076 13.1 0.8 0.12 12.5 0.6 1.3 1 0 0 1 1 1 0 GAGE protein SUR7 PF06687.7 EFX03556.1 - 6.2e-21 74.9 8.0 9.6e-21 74.3 5.5 1.3 1 0 0 1 1 1 1 SUR7/PalI family SDF PF00375.13 EFX03556.1 - 0.055 12.2 9.7 0.24 10.1 6.7 2.0 1 1 0 1 1 1 0 Sodium:dicarboxylate symporter family Claudin_2 PF13903.1 EFX03556.1 - 5.5 6.6 16.8 0.58 9.8 5.5 2.5 1 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction AAA PF00004.24 EFX03558.1 - 8.8e-98 323.6 0.0 1.1e-47 161.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EFX03558.1 - 7.7e-18 64.2 0.1 2.4e-17 62.6 0.1 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EFX03558.1 - 2.8e-13 50.1 0.0 2.4e-07 30.7 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EFX03558.1 - 4.4e-13 48.8 0.0 1.5e-05 24.1 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EFX03558.1 - 6.9e-13 48.6 0.0 8.8e-06 25.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.9 EFX03558.1 - 2.2e-12 46.8 0.5 1.4e-06 28.0 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFX03558.1 - 1.1e-11 45.0 0.2 0.0014 18.8 0.0 4.2 2 2 0 3 3 3 2 AAA domain AAA_17 PF13207.1 EFX03558.1 - 3e-11 44.1 0.0 0.00032 21.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX03558.1 - 3e-11 43.6 0.0 0.001 19.1 0.0 3.8 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.8 EFX03558.1 - 4.1e-09 35.6 0.0 0.0011 17.7 0.0 2.7 2 0 0 2 2 2 2 TIP49 C-terminus IstB_IS21 PF01695.12 EFX03558.1 - 2.7e-08 33.4 0.0 0.0064 15.9 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_19 PF13245.1 EFX03558.1 - 3.2e-08 33.2 2.2 0.0042 16.8 0.0 3.3 3 0 0 3 3 2 2 Part of AAA domain AAA_14 PF13173.1 EFX03558.1 - 7.5e-08 32.3 0.0 0.0027 17.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFX03558.1 - 1.2e-07 31.2 6.1 0.045 13.1 0.0 4.5 2 2 2 4 4 4 2 AAA domain Zeta_toxin PF06414.7 EFX03558.1 - 4e-07 29.3 0.0 0.0077 15.3 0.0 2.8 3 0 0 3 3 3 2 Zeta toxin CDC48_2 PF02933.12 EFX03558.1 - 5.5e-07 29.1 0.0 1.3e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Mg_chelatase PF01078.16 EFX03558.1 - 9.7e-07 28.1 0.3 0.028 13.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 EFX03558.1 - 1.1e-06 28.9 0.0 0.069 13.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 EFX03558.1 - 1.7e-06 27.3 1.1 0.43 9.6 0.0 3.4 2 1 1 3 3 3 2 KaiC RNA_helicase PF00910.17 EFX03558.1 - 1.8e-06 28.0 0.0 0.028 14.5 0.0 2.8 2 0 0 2 2 2 2 RNA helicase DUF815 PF05673.8 EFX03558.1 - 3.7e-06 26.0 0.0 0.0054 15.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ResIII PF04851.10 EFX03558.1 - 5.3e-06 26.3 0.0 0.0036 17.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_28 PF13521.1 EFX03558.1 - 6.4e-06 26.2 0.0 0.18 11.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.1 EFX03558.1 - 1.3e-05 25.2 0.0 0.05 13.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_24 PF13479.1 EFX03558.1 - 2.3e-05 24.0 0.3 0.16 11.5 0.0 3.1 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.21 EFX03558.1 - 2.7e-05 23.6 0.0 0.26 10.7 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.22 EFX03558.1 - 3.8e-05 23.9 0.0 0.56 10.5 0.0 3.5 2 1 0 2 2 2 2 ABC transporter PhoH PF02562.11 EFX03558.1 - 4.2e-05 22.8 0.2 0.28 10.3 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein Parvo_NS1 PF01057.12 EFX03558.1 - 5.3e-05 22.2 0.0 0.081 11.7 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 EFX03558.1 - 6e-05 22.8 0.0 5.4 6.6 0.0 3.9 2 2 2 4 4 4 0 Archaeal ATPase AAA_30 PF13604.1 EFX03558.1 - 0.00029 20.4 0.0 0.56 9.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EFX03558.1 - 0.00029 20.5 0.1 0.64 9.6 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_3 PF07726.6 EFX03558.1 - 0.00041 19.9 0.0 0.88 9.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.13 EFX03558.1 - 0.00059 19.5 0.0 1.8 8.1 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein Vps4_C PF09336.5 EFX03558.1 - 0.00081 19.2 0.2 0.0033 17.2 0.1 2.1 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_11 PF13086.1 EFX03558.1 - 0.00089 18.8 0.0 1 8.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 EFX03558.1 - 0.0017 17.4 0.0 0.64 8.9 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.10 EFX03558.1 - 0.0017 18.0 0.4 1.1 9.0 0.0 3.8 4 0 0 4 4 3 1 NTPase NB-ARC PF00931.17 EFX03558.1 - 0.0019 17.1 0.0 0.62 8.8 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain Viral_helicase1 PF01443.13 EFX03558.1 - 0.006 16.1 0.0 0.54 9.7 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase IPT PF01745.11 EFX03558.1 - 0.019 14.1 0.0 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.9 EFX03558.1 - 0.027 13.4 0.4 1.3 7.9 0.0 2.8 2 2 0 3 3 3 0 KAP family P-loop domain AAA_10 PF12846.2 EFX03558.1 - 0.052 12.9 0.6 7.1 5.9 0.0 3.5 3 1 1 4 4 4 0 AAA-like domain T2SE PF00437.15 EFX03558.1 - 0.058 12.2 0.0 2.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein UPF0079 PF02367.12 EFX03558.1 - 0.058 13.0 0.1 12 5.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 KTI12 PF08433.5 EFX03558.1 - 0.12 11.6 0.0 19 4.3 0.0 2.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Zot PF05707.7 EFX03558.1 - 0.2 11.1 0.3 35 3.7 0.1 3.5 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) CorA PF01544.13 EFX03559.1 - 2.8e-07 29.8 1.9 9.9e-07 28.0 1.3 1.9 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1282 PF06930.7 EFX03559.1 - 0.0093 15.6 0.9 0.016 14.8 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) DUF4504 PF14953.1 EFX03559.1 - 0.041 13.1 0.1 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) Asp PF00026.18 EFX03560.1 - 9.7e-66 222.1 7.8 1.3e-65 221.7 5.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX03560.1 - 4.3e-06 26.7 0.1 3.5e-05 23.8 0.1 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFX03560.1 - 1.1e-05 25.8 4.6 0.1 13.0 0.8 2.9 2 1 0 2 2 2 2 Aspartyl protease HSF_DNA-bind PF00447.12 EFX03560.1 - 0.027 14.6 0.0 0.064 13.4 0.0 1.6 1 0 0 1 1 1 0 HSF-type DNA-binding Chitin_synth_1 PF01644.12 EFX03561.1 - 3.5e-69 231.7 0.0 5.2e-69 231.2 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EFX03561.1 - 7.7e-26 89.5 0.1 1.5e-25 88.6 0.1 1.4 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EFX03561.1 - 1.5e-25 89.6 0.0 6.9e-22 77.5 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EFX03561.1 - 1.6e-11 44.3 0.1 1.6e-11 44.3 0.0 2.5 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFX03561.1 - 1.3e-08 34.9 0.0 5.6e-08 32.8 0.0 2.1 3 0 0 3 3 3 1 Glycosyltransferase like family 2 DUF3537 PF12056.3 EFX03561.1 - 1.2 7.7 6.8 0.29 9.7 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) Asparaginase PF00710.15 EFX03562.1 - 3e-100 335.1 0.0 3.9e-100 334.7 0.0 1.1 1 0 0 1 1 1 1 Asparaginase Ank_2 PF12796.2 EFX03562.1 - 9.2e-12 45.1 0.2 1.9e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFX03562.1 - 6.9e-11 41.3 0.7 2.1e-06 27.2 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 EFX03562.1 - 2.6e-08 34.1 1.9 2.3e-05 24.7 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX03562.1 - 7.3e-08 32.4 1.5 1.4e-05 25.2 0.2 3.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX03562.1 - 0.0028 17.7 0.4 0.31 11.4 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ribosomal_L18p PF00861.17 EFX03563.1 - 3.1e-42 143.5 0.1 3.1e-42 143.5 0.1 1.8 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 EFX03563.1 - 4.3e-31 107.3 10.3 4.3e-31 107.3 7.1 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DnaJ PF00226.26 EFX03564.1 - 2.5e-25 87.9 1.5 3.9e-25 87.3 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EFX03564.1 - 1.6e-24 85.5 0.6 8.4e-20 70.4 0.0 3.4 3 1 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EFX03564.1 - 1.7e-09 37.5 20.0 1.7e-09 37.5 13.9 1.9 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.14 EFX03564.1 - 9.2 5.9 6.1 11 5.8 0.7 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family GLTP PF08718.6 EFX03565.1 - 2.6e-44 150.8 0.1 6.4e-44 149.5 0.0 1.6 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) HAUS4 PF14735.1 EFX03565.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Glyco_hydro_15 PF00723.16 EFX03566.1 - 9.2e-48 162.9 0.0 4.5e-43 147.4 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 OPT PF03169.10 EFX03567.1 - 6.2e-126 421.3 42.3 7.2e-126 421.1 29.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Treslin_N PF15292.1 EFX03567.1 - 0.13 10.1 0.0 0.16 9.8 0.0 1.1 1 0 0 1 1 1 0 Treslin N-terminus ThiF PF00899.16 EFX03568.1 - 6.8e-30 103.6 0.0 1.1e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 EFX03568.1 - 0.025 14.6 0.0 0.29 11.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 EFX03568.1 - 0.15 11.1 0.0 8.9 5.4 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Herpes_gE PF02480.11 EFX03569.1 - 0.00021 19.7 0.6 0.0003 19.1 0.4 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Rifin_STEVOR PF02009.11 EFX03569.1 - 0.0024 17.5 0.0 0.0034 17.0 0.0 1.1 1 0 0 1 1 1 1 Rifin/stevor family SKG6 PF08693.5 EFX03569.1 - 0.0096 15.2 6.8 0.0096 15.2 4.7 1.9 2 0 0 2 2 2 1 Transmembrane alpha-helix domain TMEM154 PF15102.1 EFX03569.1 - 0.012 15.2 0.2 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF2029 PF09594.5 EFX03569.1 - 0.022 14.2 1.2 0.022 14.2 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2029) Syndecan PF01034.15 EFX03569.1 - 0.033 13.8 0.1 0.2 11.3 0.1 2.0 2 0 0 2 2 2 0 Syndecan domain Adeno_E3_CR2 PF02439.10 EFX03569.1 - 0.039 13.5 0.7 0.072 12.6 0.5 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.1 EFX03569.1 - 0.094 13.1 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.1 EFX03569.1 - 0.1 12.0 0.0 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF2207 PF09972.4 EFX03569.1 - 0.1 11.1 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MtrF PF09472.5 EFX03569.1 - 0.15 11.3 3.1 0.3 10.3 2.2 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF2668 PF10873.3 EFX03569.1 - 0.36 10.9 0.0 0.36 10.9 0.0 2.4 2 0 0 2 2 1 0 Protein of unknown function (DUF2668) DUF2062 PF09835.4 EFX03569.1 - 5.5 6.5 6.4 1.4 8.4 2.1 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) Ammonium_transp PF00909.16 EFX03569.1 - 6.8 5.0 13.6 10 4.4 9.4 1.1 1 0 0 1 1 1 0 Ammonium Transporter Family Glycophorin_A PF01102.13 EFX03569.1 - 8.6 6.1 11.0 20 5.0 7.6 1.7 1 1 0 1 1 1 0 Glycophorin A Glyco_hydro_43 PF04616.9 EFX03570.1 - 3.8e-33 114.8 3.6 4.8e-33 114.4 2.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 ThiF PF00899.16 EFX03571.1 - 1.7e-52 176.8 0.0 1.4e-31 109.1 0.0 2.8 2 0 0 2 2 2 2 ThiF family UBA_e1_C PF09358.5 EFX03571.1 - 2.3e-38 131.1 0.1 1.6e-37 128.4 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 EFX03571.1 - 6.4e-38 128.1 4.0 8.9e-27 92.4 0.3 2.6 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 EFX03571.1 - 2.9e-22 77.7 2.5 6.8e-20 70.1 0.4 2.5 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site Sugar_tr PF00083.19 EFX03572.1 - 5.5e-69 232.8 21.3 6.8e-69 232.5 14.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX03572.1 - 1.7e-26 92.7 24.8 2.2e-26 92.4 17.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX03572.1 - 2.6e-06 25.9 4.0 2.6e-06 25.9 2.8 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Proteasome PF00227.21 EFX03573.1 - 8.5e-49 165.4 0.0 1.1e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EFX03573.1 - 2.8e-11 42.5 0.2 5.2e-11 41.6 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature p450 PF00067.17 EFX03575.1 - 3.4e-58 197.3 0.0 9.5e-58 195.8 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.18 EFX03576.1 - 5.4e-12 45.3 1.0 9e-12 44.6 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 EFX03576.1 - 2.6e-07 30.5 0.2 5e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase PIG-H PF10181.4 EFX03577.1 - 1.9e-14 52.9 0.0 1.6e-09 37.2 0.0 2.7 3 0 0 3 3 3 2 GPI-GlcNAc transferase complex, PIG-H component TPR_11 PF13414.1 EFX03578.1 - 1.7e-54 181.3 23.3 6.5e-18 64.1 0.7 6.5 5 1 1 6 6 6 6 TPR repeat TPR_1 PF00515.23 EFX03578.1 - 1.8e-37 125.3 23.5 6.2e-05 22.4 0.0 9.6 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.12 EFX03578.1 - 4.4e-29 98.0 33.8 5.9e-06 25.8 0.1 10.8 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_12 PF13424.1 EFX03578.1 - 1e-14 54.1 11.3 1.1e-07 31.6 0.3 5.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX03578.1 - 2.6e-13 50.2 28.6 0.00021 21.8 0.0 7.9 5 2 3 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 EFX03578.1 - 9e-13 47.3 4.7 0.12 12.5 0.0 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFX03578.1 - 4e-12 44.9 23.6 0.0034 17.0 0.1 8.5 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 EFX03578.1 - 2.7e-11 43.0 21.6 0.47 11.2 0.0 9.3 6 5 4 10 10 8 4 Tetratricopeptide repeat TPR_7 PF13176.1 EFX03578.1 - 6.6e-09 34.9 11.7 0.011 15.5 0.0 7.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFX03578.1 - 1.1e-08 35.2 11.9 0.032 14.5 0.0 6.6 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 EFX03578.1 - 3.2e-08 33.2 5.5 0.0017 18.1 0.1 5.0 4 1 2 6 6 6 3 Tetratricopeptide repeat MIT PF04212.13 EFX03578.1 - 8.5e-06 25.5 14.5 0.44 10.4 0.1 5.2 5 0 0 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 EFX03578.1 - 0.81 9.7 0.0 0.81 9.7 0.0 3.8 6 0 0 6 6 5 0 Tetratricopeptide repeat IU_nuc_hydro PF01156.14 EFX03579.1 - 6.2e-20 71.6 0.0 8e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase EF-hand_1 PF00036.27 EFX03580.1 - 5.9e-24 81.4 12.0 5.8e-08 31.5 0.2 4.7 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 EFX03580.1 - 4.3e-22 75.9 4.3 3e-05 23.5 0.0 5.1 4 1 1 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 EFX03580.1 - 5.8e-20 71.1 4.5 2.4e-12 46.7 0.3 3.2 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EFX03580.1 - 1.7e-16 58.6 10.0 3.7e-05 22.8 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 EFX03580.1 - 1.7e-12 46.7 11.3 0.00025 20.6 0.7 4.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 EFX03580.1 - 2.9e-07 30.1 7.8 0.006 16.2 0.1 4.2 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 EFX03580.1 - 0.00011 21.9 0.6 0.016 15.1 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.4 EFX03580.1 - 0.01 15.8 4.1 1 9.4 0.1 3.2 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 EFX03580.1 - 0.013 15.1 2.4 1.7 8.3 0.0 3.7 4 0 0 4 4 4 0 EF hand EF-hand_2 PF09068.6 EFX03580.1 - 0.013 15.5 0.1 1.5 8.9 0.0 3.1 3 1 1 4 4 4 0 EF hand Toprim PF01751.17 EFX03580.1 - 0.024 14.5 0.0 8.7 6.3 0.0 2.3 1 1 0 2 2 2 0 Toprim domain DUF1679 PF07914.6 EFX03580.1 - 0.057 12.0 0.5 2.1 6.8 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) Rubrerythrin PF02915.12 EFX03580.1 - 0.22 11.8 1.0 2 8.7 0.1 2.4 3 0 0 3 3 3 0 Rubrerythrin RRM_1 PF00076.17 EFX03581.1 - 2.2e-84 277.0 3.1 3.9e-23 80.8 0.1 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03581.1 - 2e-57 191.0 0.2 1.8e-16 59.8 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03581.1 - 4.6e-40 135.2 0.0 1.9e-08 33.9 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 EFX03581.1 - 7.1e-28 96.0 1.2 7.1e-28 96.0 0.8 3.6 5 0 0 5 5 5 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.1 EFX03581.1 - 0.0002 21.0 0.7 12 5.7 0.0 4.7 4 1 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 EFX03581.1 - 0.00022 20.9 1.4 2.4 7.9 0.1 3.6 3 0 0 3 3 3 1 Limkain b1 CbiG_mid PF11761.3 EFX03581.1 - 0.00061 19.9 0.1 3.9 7.7 0.0 3.7 3 0 0 3 3 3 2 Cobalamin biosynthesis central region YflT PF11181.3 EFX03581.1 - 0.02 15.0 4.5 1.8 8.7 0.2 3.6 3 0 0 3 3 3 0 Heat induced stress protein YflT OB_RNB PF08206.6 EFX03581.1 - 0.23 11.0 2.4 6.5 6.3 0.0 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain Glyco_hydro_76 PF03663.9 EFX03582.1 - 4.3e-138 460.7 8.6 5.7e-138 460.3 6.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 EFX03582.1 - 0.051 12.6 5.8 1.7 7.5 0.1 3.1 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 MAS20 PF02064.10 EFX03584.1 - 2.5e-16 59.7 0.3 8.3e-16 57.9 0.2 1.7 1 1 0 1 1 1 1 MAS20 protein import receptor EcoEI_R_C PF08463.5 EFX03584.1 - 0.3 10.9 2.3 1.2 8.9 0.7 2.1 1 1 0 2 2 2 0 EcoEI R protein C-terminal RRM_1 PF00076.17 EFX03585.1 - 1.2e-17 63.2 0.0 1.3e-09 37.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03585.1 - 1.2e-15 57.2 0.0 3.3e-08 33.3 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03585.1 - 2.5e-05 24.0 0.1 0.63 9.9 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3665 PF12427.3 EFX03585.1 - 0.27 10.6 3.6 4.4 6.7 0.2 2.8 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase Surp PF01805.15 EFX03586.1 - 9.2e-13 47.6 0.0 1.6e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Surp module RRM_6 PF14259.1 EFX03586.1 - 0.047 13.6 0.0 0.089 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) UPF0160 PF03690.8 EFX03588.1 - 6.5e-113 377.3 0.1 7.5e-113 377.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ank_2 PF12796.2 EFX03589.1 - 3.8e-112 366.8 13.2 3.9e-17 62.3 0.4 10.8 3 3 7 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.25 EFX03589.1 - 9.8e-87 280.7 38.1 2.6e-07 30.1 0.0 21.8 22 0 0 22 22 22 18 Ankyrin repeat Ank_4 PF13637.1 EFX03589.1 - 3.6e-83 272.6 12.0 1e-07 32.2 0.0 15.9 10 5 5 16 16 16 14 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX03589.1 - 3.3e-73 240.0 28.7 8.5e-07 29.0 0.0 18.5 8 6 10 18 18 18 16 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX03589.1 - 4e-71 227.7 16.9 0.00023 21.0 0.0 21.7 23 0 0 23 23 23 14 Ankyrin repeat SPRY PF00622.23 EFX03589.1 - 4e-14 52.7 0.1 8.5e-14 51.7 0.1 1.6 1 0 0 1 1 1 1 SPRY domain NACHT PF05729.7 EFX03590.1 - 4.1e-17 62.3 0.0 3.2e-16 59.4 0.0 2.3 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.17 EFX03590.1 - 1.1e-06 27.7 0.1 2.1e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 EFX03590.1 - 6.5e-06 26.3 0.0 2.4e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX03590.1 - 0.0012 19.6 0.2 0.005 17.6 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFX03590.1 - 0.0035 17.2 0.6 0.052 13.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EFX03590.1 - 0.013 15.7 0.2 0.071 13.4 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX03590.1 - 0.017 15.0 0.7 0.1 12.5 0.0 2.6 3 1 0 3 3 3 0 AAA ATPase domain RNA_helicase PF00910.17 EFX03590.1 - 0.035 14.2 0.0 0.14 12.3 0.0 2.1 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 EFX03590.1 - 0.054 13.1 0.1 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 NTPase AAA_10 PF12846.2 EFX03590.1 - 0.067 12.6 0.0 0.33 10.3 0.0 1.8 1 1 0 2 2 2 0 AAA-like domain PhageMin_Tail PF10145.4 EFX03590.1 - 0.071 12.7 0.2 0.14 11.7 0.1 1.6 1 0 0 1 1 1 0 Phage-related minor tail protein DUF258 PF03193.11 EFX03590.1 - 0.078 12.1 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ArgK PF03308.11 EFX03590.1 - 0.15 10.8 0.0 0.32 9.7 0.0 1.5 1 0 0 1 1 1 0 ArgK protein Arm PF00514.18 EFX03591.1 - 5.4e-69 225.8 31.8 6.2e-13 48.0 0.1 11.3 12 0 0 12 12 12 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EFX03591.1 - 2.4e-21 75.7 16.0 4.4e-06 26.8 0.1 7.6 2 2 4 6 6 6 6 HEAT repeats HEAT PF02985.17 EFX03591.1 - 4.1e-18 63.7 17.6 0.011 15.7 0.0 10.0 11 0 0 11 11 11 5 HEAT repeat Adaptin_N PF01602.15 EFX03591.1 - 1.2e-15 56.8 19.8 1.8e-10 39.8 2.2 2.9 1 1 2 3 3 3 3 Adaptin N terminal region Arm_2 PF04826.8 EFX03591.1 - 1.2e-13 50.8 5.5 0.00015 21.0 0.0 3.4 2 1 1 3 3 3 3 Armadillo-like HEAT_EZ PF13513.1 EFX03591.1 - 1.1e-11 44.7 18.9 0.082 13.4 0.1 8.6 7 2 3 10 10 10 6 HEAT-like repeat KAP PF05804.7 EFX03591.1 - 4.9e-09 34.6 0.4 1.2e-08 33.4 0.1 1.8 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.9 EFX03591.1 - 2.9e-07 29.9 1.8 0.0074 15.4 0.2 3.6 2 1 1 3 3 3 2 V-ATPase subunit H DUF908 PF06012.7 EFX03591.1 - 0.00011 21.6 2.9 0.14 11.4 0.1 4.0 3 1 2 5 5 5 1 Domain of Unknown Function (DUF908) DUF2454 PF10521.4 EFX03591.1 - 0.016 14.1 0.1 0.031 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2454) HEAT_PBS PF03130.11 EFX03591.1 - 0.022 15.2 8.5 5.3 7.8 0.2 6.4 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFX03591.1 - 0.054 13.8 0.1 5.4 7.4 0.0 3.6 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region RPN7 PF10602.4 EFX03593.1 - 1.7e-47 161.0 0.0 2.8e-47 160.3 0.0 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 EFX03593.1 - 9e-16 58.0 0.1 3.4e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 PCI domain SWIRM PF04433.12 EFX03594.1 - 1.7e-35 120.9 0.2 3.2e-35 120.1 0.1 1.5 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 EFX03594.1 - 1.5e-06 28.1 0.0 4.1e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.12 EFX03594.1 - 2.1e-05 23.9 2.4 3.8e-05 23.1 1.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.1 EFX03594.1 - 0.00029 20.8 0.1 0.00072 19.6 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ERO1 PF04137.10 EFX03595.1 - 5.3e-138 459.9 0.0 6.7e-138 459.5 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) CKS PF01111.14 EFX03595.1 - 5.7e-33 112.5 2.9 1.9e-32 110.8 1.0 2.3 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit SecG PF03840.9 EFX03596.1 - 0.23 11.2 4.8 0.31 10.8 0.2 2.9 2 1 1 3 3 3 0 Preprotein translocase SecG subunit DUF3684 PF12449.3 EFX03597.1 - 0 1254.9 0.0 0 1254.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 EFX03597.1 - 0.0001 21.9 0.0 0.00077 19.1 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MecA_N PF05223.6 EFX03597.1 - 0.14 12.1 0.2 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain Mito_carr PF00153.22 EFX03598.1 - 3.4e-16 58.7 3.9 3.1e-07 30.0 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF1212 PF06738.7 EFX03598.1 - 0.079 12.4 1.8 6.4 6.1 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1212) HNH_2 PF13391.1 EFX03599.1 - 4.9e-08 32.6 0.2 1.5e-07 31.0 0.1 1.9 2 0 0 2 2 2 1 HNH endonuclease LNS2 PF08235.8 EFX03600.1 - 7.5e-71 236.7 0.0 1.1e-70 236.2 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 EFX03600.1 - 1.7e-40 137.1 0.0 1e-39 134.6 0.0 2.2 2 0 0 2 2 2 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.9 EFX03600.1 - 0.0028 17.0 0.0 0.16 11.3 0.0 2.5 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Fe_hyd_lg_C PF02906.9 EFX03601.1 - 2.7e-57 194.1 0.0 1.5e-56 191.8 0.0 2.0 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain HMG-CoA_red PF00368.13 EFX03602.1 - 3.3e-156 519.6 4.6 4.4e-156 519.2 3.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 EFX03602.1 - 2.8e-43 147.2 0.2 5.2e-43 146.3 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 EFX03602.1 - 2.5e-14 52.9 2.0 4.4e-08 32.7 0.3 2.6 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 EFX03602.1 - 2.3e-07 29.1 1.9 2.3e-07 29.1 1.3 1.5 2 0 0 2 2 2 1 Patched family Ank_2 PF12796.2 EFX03603.1 - 1.5e-26 92.5 0.4 1.5e-09 38.0 0.0 4.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX03603.1 - 3.8e-25 86.4 1.2 0.00016 21.3 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 EFX03603.1 - 1.1e-16 60.4 5.5 1.4e-06 28.3 0.1 6.0 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX03603.1 - 1.6e-13 50.7 0.2 3.3e-05 24.2 0.1 5.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX03603.1 - 1.7e-11 43.2 0.1 0.14 12.5 0.0 7.0 6 0 0 6 6 6 2 Ankyrin repeat AAA_16 PF13191.1 EFX03603.1 - 0.00014 21.9 0.0 0.0005 20.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX03603.1 - 0.00038 20.5 0.0 0.0014 18.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFX03603.1 - 0.001 18.5 0.0 0.0033 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EFX03603.1 - 0.021 15.0 0.0 0.12 12.6 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EFX03603.1 - 0.023 14.1 0.0 0.072 12.5 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF948 PF06103.6 EFX03603.1 - 0.036 13.9 0.1 0.22 11.3 0.0 2.4 2 0 0 2 2 1 0 Bacterial protein of unknown function (DUF948) AAA_33 PF13671.1 EFX03603.1 - 0.072 12.9 0.0 0.33 10.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain Ribosomal_L11_N PF03946.9 EFX03604.1 - 3.1e-26 90.5 0.1 4.3e-26 90.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EFX03604.1 - 1.1e-21 76.6 0.2 2.6e-21 75.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Ribosomal_S5_C PF03719.10 EFX03605.1 - 2.4e-16 58.7 0.0 5.4e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 EFX03605.1 - 1.4e-13 50.4 0.7 2.8e-13 49.4 0.5 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain ZZ PF00569.12 EFX03606.1 - 8e-11 41.3 7.8 1.4e-10 40.5 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF2052 PF09747.4 EFX03606.1 - 0.0014 18.5 15.6 0.13 12.2 3.3 2.7 2 0 0 2 2 2 2 Coiled-coil domain containing protein (DUF2052) EF-hand_1 PF00036.27 EFX03606.1 - 0.094 12.0 0.9 1.2 8.5 0.6 2.6 2 0 0 2 2 2 0 EF hand C1_3 PF07649.7 EFX03606.1 - 0.49 10.4 11.0 0.27 11.3 6.1 1.7 2 0 0 2 2 2 0 C1-like domain PALP PF00291.20 EFX03607.1 - 7e-58 196.2 6.1 4.1e-57 193.7 4.2 1.9 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Chorion_2 PF03964.10 EFX03607.1 - 0.6 10.6 7.2 2.8 8.5 0.4 2.4 2 0 0 2 2 2 0 Chorion family 2 Thioredoxin PF00085.15 EFX03608.1 - 1.3e-33 114.7 0.0 2e-25 88.4 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.1 EFX03608.1 - 3.4e-09 36.7 0.0 0.0041 16.9 0.0 3.0 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 EFX03608.1 - 1.1e-06 28.8 5.8 1.2e-05 25.4 0.5 3.4 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX03608.1 - 1.1e-05 25.3 0.0 0.012 15.7 0.0 3.8 3 1 1 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.1 EFX03608.1 - 0.0099 15.8 0.0 0.035 14.1 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin-like DUF1510 PF07423.6 EFX03608.1 - 0.03 13.6 4.3 0.05 12.9 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Thioredoxin_9 PF14595.1 EFX03608.1 - 0.035 13.6 0.7 0.061 12.8 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin ERp29_N PF07912.8 EFX03608.1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 ERp29, N-terminal domain DUF4544 PF15077.1 EFX03608.1 - 0.31 10.5 2.4 0.38 10.2 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4544) Metallophos PF00149.23 EFX03610.1 - 2.2e-41 141.4 1.0 2.2e-41 141.4 0.7 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase TauD PF02668.11 EFX03610.1 - 3.9e-37 128.3 0.1 6.7e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NinE PF05322.6 EFX03611.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 NINE Protein AA_permease PF00324.16 EFX03612.1 - 1.9e-137 458.5 36.0 2.1e-137 458.3 25.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX03612.1 - 3.9e-44 150.8 38.6 5.2e-44 150.4 26.8 1.0 1 0 0 1 1 1 1 Amino acid permease CRAL_TRIO PF00650.15 EFX03614.1 - 3.4e-46 156.6 0.9 5.2e-46 156.0 0.1 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFX03614.1 - 2e-15 56.6 0.0 7.4e-15 54.8 0.0 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EFX03614.1 - 4.6e-12 46.0 0.0 9.2e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain WWbp PF10349.4 EFX03615.1 - 3 8.7 5.5 9.3 7.1 3.8 1.8 1 0 0 1 1 1 0 WW-domain ligand protein SOG2 PF10428.4 EFX03616.1 - 7.5 5.0 16.8 4.4 5.8 7.6 2.5 2 2 0 2 2 2 0 RAM signalling pathway protein DUF2413 PF10310.4 EFX03617.1 - 4.6e-125 417.9 0.0 5.6e-125 417.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2413) Telomere_reg-2 PF10193.4 EFX03618.1 - 1.7e-38 131.4 0.0 5.5e-38 129.7 0.0 2.0 2 0 0 2 2 2 1 Telomere length regulation protein Zn_clus PF00172.13 EFX03619.1 - 2.1e-06 27.5 8.8 4.2e-06 26.5 6.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aa_trans PF01490.13 EFX03620.1 - 2.2e-83 280.0 28.6 3e-83 279.5 19.8 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ERAP1_C PF11838.3 EFX03621.1 - 0.036 13.2 0.0 0.043 13.0 0.0 1.1 1 0 0 1 1 1 0 ERAP1-like C-terminal domain COG5 PF10392.4 EFX03622.1 - 1.1e-40 138.6 1.2 7.2e-40 136.0 0.0 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Bcr-Abl_Oligo PF09036.5 EFX03622.1 - 0.16 11.9 0.3 0.82 9.6 0.0 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF1279 PF06916.8 EFX03623.1 - 7e-30 103.1 0.0 1.2e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) RRP7 PF12923.2 EFX03623.1 - 0.055 13.4 0.5 0.1 12.6 0.3 1.4 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) RE_Eco29kI PF09517.5 EFX03623.1 - 0.059 12.6 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Eco29kI restriction endonuclease Tubulin PF00091.20 EFX03624.1 - 6.4e-52 176.4 0.1 1.9e-45 155.3 0.0 2.2 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFX03624.1 - 3.6e-44 149.8 0.2 9e-44 148.5 0.0 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Chorismate_bind PF00425.13 EFX03625.1 - 1.3e-63 214.7 0.0 1.9e-63 214.2 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 EFX03625.1 - 8.3e-25 87.3 0.0 2.2e-24 85.9 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 EFX03625.1 - 8.6e-13 48.4 0.0 1.8e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 EFX03625.1 - 0.00017 21.1 0.2 0.019 14.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase C26 dCMP_cyt_deam_1 PF00383.17 EFX03626.1 - 9.4e-26 89.4 0.6 1.4e-25 88.8 0.4 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region AAA_17 PF13207.1 EFX03626.1 - 6.5e-05 23.7 0.0 0.00018 22.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX03626.1 - 0.006 16.8 0.2 0.15 12.4 0.1 2.2 1 1 0 2 2 2 1 AAA domain CoaE PF01121.15 EFX03626.1 - 0.0077 15.6 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase RabGGT_insert PF07711.6 EFX03626.1 - 0.0095 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 Rab geranylgeranyl transferase alpha-subunit, insert domain HA2 PF04408.18 EFX03627.1 - 5.5e-17 61.6 0.1 2.6e-16 59.4 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFX03627.1 - 1.2e-12 47.5 0.0 3.2e-12 46.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 EFX03627.1 - 4.9e-09 36.0 0.1 2.1e-08 33.9 0.0 2.2 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 EFX03627.1 - 4.8e-07 29.4 0.0 1.4e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFX03627.1 - 0.00039 20.5 0.0 0.0012 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 EFX03627.1 - 0.00052 18.9 0.0 0.0011 17.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 EFX03627.1 - 0.0016 18.1 0.1 0.0066 16.1 0.1 2.1 1 0 0 1 1 1 1 Part of AAA domain KaiC PF06745.8 EFX03627.1 - 0.034 13.2 0.0 0.076 12.1 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.1 EFX03627.1 - 0.086 12.3 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EFX03627.1 - 0.22 11.8 0.0 0.22 11.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain G_glu_transpept PF01019.16 EFX03628.1 - 1.1e-122 410.1 0.2 1.5e-122 409.7 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Bd3614_N PF14442.1 EFX03628.1 - 0.055 13.4 2.7 0.13 12.2 1.9 1.6 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal PfkB PF00294.19 EFX03630.1 - 1.4e-44 152.4 1.4 3e-44 151.3 1.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Peptidase_S28 PF05577.7 EFX03631.1 - 7.8e-45 153.2 0.0 3.3e-38 131.3 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Ank_2 PF12796.2 EFX03632.1 - 8.9e-19 67.6 0.3 1.8e-18 66.6 0.2 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX03632.1 - 3.4e-17 62.4 0.1 2.2e-11 43.9 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 EFX03632.1 - 4.5e-17 60.9 1.1 6.6e-08 31.9 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 EFX03632.1 - 1.4e-11 43.4 0.4 0.00014 21.7 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 EFX03632.1 - 2.7e-09 36.9 0.0 6.2e-09 35.8 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ponericin PF07442.6 EFX03634.1 - 0.087 12.6 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Ponericin Peptidase_S8 PF00082.17 EFX03635.1 - 2.2e-25 89.3 8.2 4.4e-25 88.3 5.7 1.5 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 EFX03635.1 - 1.3e-07 31.9 0.2 7e-07 29.6 0.0 2.3 3 0 0 3 3 3 1 Fn3-like domain (DUF1034) FlgD_ig PF13860.1 EFX03635.1 - 0.0061 16.2 0.0 0.025 14.3 0.0 2.0 1 0 0 1 1 1 1 FlgD Ig-like domain FAD_binding_4 PF01565.18 EFX03636.1 - 1.8e-28 98.7 3.2 3.4e-28 97.8 2.2 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX03636.1 - 9.8e-11 41.3 0.1 1.9e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Septin PF00735.13 EFX03637.1 - 3.3e-116 387.2 0.2 4.8e-116 386.6 0.1 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EFX03637.1 - 5.9e-07 29.4 0.0 1.1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFX03637.1 - 1e-06 28.3 0.2 5.7e-05 22.6 0.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EFX03637.1 - 1.1e-05 24.6 0.0 2.9e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 EFX03637.1 - 0.0022 18.5 0.1 0.0081 16.6 0.1 2.0 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 EFX03637.1 - 0.003 17.6 0.4 0.011 15.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.1 EFX03637.1 - 0.0033 17.0 0.1 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AIG1 PF04548.11 EFX03637.1 - 0.0063 15.6 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family FtsK_SpoIIIE PF01580.13 EFX03637.1 - 0.0071 15.8 0.0 0.02 14.3 0.0 1.7 1 0 0 1 1 1 1 FtsK/SpoIIIE family IIGP PF05049.8 EFX03637.1 - 0.0075 15.1 0.0 0.013 14.3 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Pox_A32 PF04665.7 EFX03637.1 - 0.012 14.8 0.1 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Ras PF00071.17 EFX03637.1 - 0.017 14.4 0.5 0.054 12.8 0.4 1.8 1 1 0 1 1 1 0 Ras family T2SE PF00437.15 EFX03637.1 - 0.037 12.9 0.4 0.11 11.3 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.7 EFX03637.1 - 0.042 13.5 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 EFX03637.1 - 0.045 14.0 0.2 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter DUF2968 PF11180.3 EFX03637.1 - 0.049 13.0 5.3 0.13 11.6 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Sigma54_activat PF00158.21 EFX03637.1 - 0.071 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Ribosomal_L6e PF01159.14 EFX03637.1 - 0.073 13.3 4.2 3.8 7.7 0.1 3.3 3 0 0 3 3 3 0 Ribosomal protein L6e KAP_NTPase PF07693.9 EFX03637.1 - 0.082 11.8 1.8 0.18 10.7 1.2 1.7 1 1 0 1 1 1 0 KAP family P-loop domain PduV-EutP PF10662.4 EFX03637.1 - 0.09 12.2 0.8 2.8 7.4 0.2 2.7 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 EFX03637.1 - 0.092 12.7 2.1 0.35 10.8 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain Arch_ATPase PF01637.13 EFX03637.1 - 0.097 12.3 0.0 0.097 12.3 0.0 1.8 2 0 0 2 2 2 0 Archaeal ATPase Dynamin_N PF00350.18 EFX03637.1 - 0.1 12.4 7.6 0.78 9.5 0.0 3.1 2 1 1 3 3 3 0 Dynamin family Atg14 PF10186.4 EFX03637.1 - 0.12 11.3 5.4 0.26 10.1 3.8 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 RNA_helicase PF00910.17 EFX03637.1 - 0.12 12.5 0.0 0.36 11.0 0.0 1.8 2 0 0 2 2 1 0 RNA helicase ArgK PF03308.11 EFX03637.1 - 0.13 10.9 2.2 0.73 8.5 0.0 2.7 3 0 0 3 3 3 0 ArgK protein Seryl_tRNA_N PF02403.17 EFX03637.1 - 0.59 10.1 6.9 0.64 10.0 2.4 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Myc-LZ PF02344.10 EFX03637.1 - 0.97 9.1 9.0 0.36 10.4 1.6 2.6 2 0 0 2 2 2 0 Myc leucine zipper domain DivIC PF04977.10 EFX03637.1 - 1.5 8.3 8.0 0.32 10.5 1.9 2.4 2 0 0 2 2 2 0 Septum formation initiator eIF-3_zeta PF05091.7 EFX03638.1 - 5.1e-191 635.7 0.0 9.1e-191 634.9 0.0 1.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_1 PF00170.16 EFX03638.1 - 0.0042 17.0 10.1 0.0081 16.0 7.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor DUF569 PF04601.8 EFX03638.1 - 0.066 12.6 0.0 0.16 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF569) DUF2529 PF10740.4 EFX03638.1 - 0.24 10.8 0.0 0.55 9.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2529) bZIP_2 PF07716.10 EFX03638.1 - 0.93 9.3 11.5 0.39 10.5 2.3 2.3 2 0 0 2 2 2 0 Basic region leucine zipper DUF904 PF06005.7 EFX03638.1 - 0.97 9.7 6.0 0.33 11.2 2.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Dynactin PF12455.3 EFX03639.1 - 2.5e-86 288.9 0.6 2.5e-86 288.9 0.4 3.6 3 1 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.20 EFX03639.1 - 3.2e-22 77.9 0.3 6e-22 77.1 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF1386 PF07138.6 EFX03639.1 - 0.17 10.9 2.3 0.34 9.9 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1386) Phostensin_N PF13916.1 EFX03640.1 - 0.13 12.2 6.2 0.59 10.1 4.3 2.2 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Ank_2 PF12796.2 EFX03641.1 - 3.1e-13 49.8 0.0 7.7e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) NACHT PF05729.7 EFX03641.1 - 8.3e-12 45.0 0.0 2.3e-11 43.6 0.0 1.7 1 1 0 1 1 1 1 NACHT domain Ank PF00023.25 EFX03641.1 - 1.1e-10 40.7 0.0 2.3e-08 33.4 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.1 EFX03641.1 - 1.4e-09 37.2 0.0 6.3e-07 29.0 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 EFX03641.1 - 2.2e-08 34.0 0.0 6.7e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX03641.1 - 1.3e-07 31.8 0.0 3.6e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) AAA_16 PF13191.1 EFX03641.1 - 0.00012 22.1 1.3 0.00055 19.9 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX03641.1 - 0.0075 16.4 0.1 0.067 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFX03641.1 - 0.034 13.5 0.0 0.1 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFX03641.1 - 0.04 13.3 0.1 0.3 10.4 0.0 2.4 2 1 0 2 2 2 0 AAA-like domain IBN_N PF03810.14 EFX03642.1 - 2.2e-13 49.8 0.1 5.1e-12 45.5 0.0 3.2 3 1 1 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFX03642.1 - 9.5e-05 22.3 4.4 0.0005 19.9 0.1 3.4 4 0 0 4 4 4 1 Exportin 1-like protein LIM PF00412.17 EFX03643.1 - 1.3e-24 85.9 12.8 1.6e-12 47.3 3.5 2.3 2 0 0 2 2 2 2 LIM domain FAM196 PF15265.1 EFX03644.1 - 1.1 8.3 23.2 1.4 8.1 16.1 1.0 1 0 0 1 1 1 0 FAM196 family DUF605 PF04652.11 EFX03644.1 - 1.4 8.1 29.6 1.8 7.9 20.5 1.1 1 0 0 1 1 1 0 Vta1 like CCDC84 PF14968.1 EFX03644.1 - 2 7.8 10.2 2.7 7.4 7.1 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Hid1 PF12722.2 EFX03644.1 - 3.6 5.1 16.8 4.6 4.8 11.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hex_IIIa PF02455.11 EFX03644.1 - 4.5 5.8 13.3 7.4 5.1 9.2 1.3 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Chromo PF00385.19 EFX03645.1 - 1.3e-13 50.3 0.2 2.2e-13 49.6 0.2 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Avl9 PF09794.4 EFX03647.1 - 4.8e-142 472.9 0.0 6.2e-142 472.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 EFX03647.1 - 2.4e-06 27.2 0.0 0.0015 18.2 0.0 2.3 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.4 EFX03647.1 - 0.0014 17.9 0.6 0.017 14.4 0.0 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) Nop14 PF04147.7 EFX03647.1 - 0.71 7.7 9.4 1.3 6.9 6.5 1.3 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 EFX03647.1 - 1.2 7.7 16.0 2.7 6.6 11.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 EFX03647.1 - 5.2 6.2 9.5 9.4 5.3 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein Cupin_8 PF13621.1 EFX03648.1 - 5.9e-12 45.6 0.2 1.8e-10 40.7 0.1 2.6 1 1 1 2 2 2 1 Cupin-like domain Cupin_4 PF08007.7 EFX03648.1 - 2.3e-08 33.6 0.0 3.7e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.17 EFX03648.1 - 0.0023 18.1 0.0 0.0038 17.4 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.6 EFX03648.1 - 0.0075 15.7 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Pribosyltran_N PF13793.1 EFX03649.1 - 8.2e-42 141.6 0.0 1.6e-40 137.4 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EFX03649.1 - 2.3e-33 115.5 0.0 1.7e-28 99.6 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EFX03649.1 - 4.9e-07 29.4 0.1 0.00028 20.6 0.0 2.9 3 0 0 3 3 3 2 Phosphoribosyl transferase domain TFIID-31kDa PF02291.10 EFX03650.1 - 1.3e-24 86.4 0.0 9.4e-24 83.6 0.0 2.2 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit BaxI_1 PF12811.2 EFX03650.1 - 0.4 9.7 2.8 0.58 9.2 2.0 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like Spore_coat_CotO PF14153.1 EFX03650.1 - 0.41 10.0 6.7 0.65 9.4 4.6 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Spt20 PF12090.3 EFX03650.1 - 0.5 9.6 4.5 0.81 9.0 3.1 1.3 1 0 0 1 1 1 0 Spt20 family Suf PF05843.9 EFX03650.1 - 1.2 8.7 10.1 1.7 8.3 7.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DHHW PF14286.1 EFX03650.1 - 2.9 7.1 5.7 4.3 6.5 3.9 1.2 1 0 0 1 1 1 0 DHHW protein Med15 PF09606.5 EFX03650.1 - 4.3 5.4 27.9 6.1 4.9 19.3 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF2A PF08662.6 EFX03651.1 - 2.5e-78 262.2 0.0 1.2e-77 260.0 0.0 2.1 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 EFX03651.1 - 0.0041 16.9 6.2 6.1 6.8 0.0 5.3 5 1 0 5 5 5 1 WD domain, G-beta repeat CDV3 PF15359.1 EFX03651.1 - 0.027 14.5 0.5 0.027 14.5 0.4 2.5 4 0 0 4 4 4 0 Carnitine deficiency-associated protein 3 FH2 PF02181.18 EFX03652.1 - 9.7e-76 255.0 0.6 9.7e-76 255.0 0.4 1.6 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.8 EFX03652.1 - 3.3e-65 218.9 0.0 3.3e-65 218.9 0.0 2.3 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 EFX03652.1 - 1.1e-55 188.0 3.3 1.2e-54 184.6 1.0 2.6 1 1 1 2 2 2 2 Diaphanous FH3 Domain DUF1989 PF09347.5 EFX03653.1 - 1e-43 148.6 0.1 1.1e-24 86.8 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF1989) AA_permease_2 PF13520.1 EFX03654.1 - 1.2e-39 136.1 47.9 8.2e-38 130.0 33.2 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX03654.1 - 3.3e-17 61.9 38.7 9e-09 34.1 6.9 2.1 2 0 0 2 2 2 2 Amino acid permease Myotub-related PF06602.9 EFX03655.1 - 4.9e-123 410.4 0.0 6.4e-123 410.0 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Innate_immun PF12782.2 EFX03657.1 - 0.46 9.6 14.1 0.67 9.1 9.8 1.3 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family SelP_N PF04592.9 EFX03657.1 - 1.9 7.8 18.5 2.8 7.2 12.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region UQ_con PF00179.21 EFX03658.1 - 2.4e-47 159.8 0.0 2.7e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX03658.1 - 7.8e-05 22.4 0.0 9.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EFX03658.1 - 0.042 13.7 0.3 0.068 13.0 0.2 1.6 1 1 0 1 1 1 0 RWD domain BRO1 PF03097.13 EFX03661.1 - 4.3e-129 430.5 0.0 4.3e-129 430.5 0.0 2.9 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EFX03661.1 - 1.3e-90 303.3 19.9 2e-90 302.7 13.8 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Clat_adaptor_s PF01217.15 EFX03661.1 - 9.5e-55 184.2 3.1 1.1e-54 183.9 1.1 1.9 2 0 0 2 2 2 1 Clathrin adaptor complex small chain DUF4407 PF14362.1 EFX03661.1 - 6.1 5.7 14.6 1.1 8.1 6.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Syntaxin-6_N PF09177.6 EFX03661.1 - 8.9 6.7 11.7 3.7 8.0 1.3 3.2 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Epimerase PF01370.16 EFX03662.1 - 8.6e-07 28.6 0.0 6.1e-06 25.8 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EFX03662.1 - 0.00018 20.8 0.0 0.00035 19.9 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 EFX03662.1 - 0.00072 18.5 0.0 0.0016 17.4 0.0 1.6 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.1 EFX03662.1 - 0.003 17.5 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX03662.1 - 0.043 12.5 0.0 0.088 11.4 0.0 1.5 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family MFS_1 PF07690.11 EFX03664.1 - 1.8e-32 112.4 31.7 2.6e-32 111.9 18.2 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 EFX03664.1 - 0.0086 14.1 0.8 0.018 13.1 0.1 1.8 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Methyltransf_23 PF13489.1 EFX03665.1 - 1.9e-15 56.9 0.0 2.6e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03665.1 - 8.7e-10 39.1 0.1 2.3e-08 34.5 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03665.1 - 5.7e-07 29.2 0.0 0.018 14.6 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03665.1 - 6.4e-07 29.7 0.0 1.4e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03665.1 - 0.00012 22.5 0.1 0.0021 18.4 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX03665.1 - 0.0019 17.2 0.0 0.0046 16.0 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 EFX03665.1 - 0.0037 17.5 0.0 0.016 15.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX03665.1 - 0.0067 16.4 0.1 0.018 15.0 0.1 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 EFX03665.1 - 0.017 14.2 0.0 0.15 11.1 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.15 EFX03665.1 - 0.03 13.3 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Apq12 PF12716.2 EFX03666.1 - 3.1e-08 33.1 14.4 5.1e-08 32.4 10.0 1.4 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis DUF4131 PF13567.1 EFX03666.1 - 0.068 12.5 3.5 0.1 11.9 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) YqhR PF11085.3 EFX03666.1 - 0.087 12.3 0.1 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Conserved membrane protein YqhR DICT PF10069.4 EFX03666.1 - 0.39 10.2 4.0 0.31 10.5 0.9 2.0 2 0 0 2 2 2 0 Sensory domain found in DIguanylate Cyclases & Two-component systems ING PF12998.2 EFX03667.1 - 1.4e-07 31.7 0.2 2.6e-06 27.6 0.2 2.5 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding SPX PF03105.14 EFX03667.1 - 0.0017 18.1 1.8 0.0017 18.1 1.2 1.8 2 0 0 2 2 2 1 SPX domain Mnd1 PF03962.10 EFX03667.1 - 0.49 10.0 4.9 0.94 9.1 3.4 1.5 1 0 0 1 1 1 0 Mnd1 family Chitin_synth_2 PF03142.10 EFX03668.1 - 4.3e-232 771.2 0.2 5.9e-232 770.7 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.16 EFX03668.1 - 3.9e-60 203.6 0.0 3e-59 200.7 0.0 2.2 1 1 0 1 1 1 1 Myosin head (motor domain) Glyco_trans_2_3 PF13632.1 EFX03668.1 - 3e-18 66.2 3.7 1e-17 64.4 2.6 2.0 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFX03668.1 - 3.6e-15 56.3 0.0 7.7e-13 48.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 DEK_C PF08766.6 EFX03668.1 - 5.1e-15 54.9 1.1 4.1e-14 52.0 0.6 2.3 2 0 0 2 2 2 1 DEK C terminal domain Cyt-b5 PF00173.23 EFX03668.1 - 2.3e-11 43.3 0.0 5.7e-06 26.0 0.0 3.1 2 1 1 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 EFX03668.1 - 6.4e-07 28.8 0.0 1.6e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EFX03668.1 - 0.0012 18.6 0.0 0.014 15.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 INO80_Ies4 PF08193.6 EFX03669.1 - 1.1e-48 166.1 17.3 1.1e-48 166.1 12.0 1.9 1 1 0 1 1 1 1 INO80 complex subunit Ies4 zf-CCHC_4 PF14392.1 EFX03670.1 - 2.7e-05 23.7 11.2 0.027 14.1 0.5 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC PF00098.18 EFX03670.1 - 1.1 9.3 30.5 0.058 13.3 1.8 4.6 5 0 0 5 5 5 0 Zinc knuckle ATP_bind_4 PF01902.12 EFX03671.1 - 7.6e-17 61.4 0.0 7.7e-11 41.7 0.0 2.9 1 1 1 2 2 2 2 ATP-binding region Ribonuc_L-PSP PF01042.16 EFX03671.1 - 1.9e-09 37.3 0.2 6.4e-05 22.7 0.0 4.3 3 1 0 3 3 3 3 Endoribonuclease L-PSP Fungal_trans PF04082.13 EFX03672.1 - 2.1e-12 46.4 0.0 3.5e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFX03672.1 - 3.7e-07 30.1 11.2 0.0023 18.1 0.1 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type Zn_clus PF00172.13 EFX03672.1 - 2.4e-06 27.3 8.5 2.4e-06 27.3 5.9 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.1 EFX03672.1 - 4.6e-06 26.6 11.0 1.1e-05 25.4 1.8 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 EFX03672.1 - 0.0057 16.8 4.8 0.11 12.6 1.5 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EFX03672.1 - 0.0085 16.3 21.9 0.019 15.2 2.6 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 EFX03672.1 - 0.26 10.9 5.0 1.6 8.5 0.1 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-Di19 PF05605.7 EFX03672.1 - 0.71 10.0 6.4 2.2 8.4 0.4 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 EFX03672.1 - 5.6 7.2 8.2 19 5.5 1.5 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFX03672.1 - 5.7 6.9 20.3 1 9.3 0.6 4.9 5 0 0 5 5 5 0 C2H2-type zinc finger Peptidase_M17 PF00883.16 EFX03673.1 - 0.06 12.2 1.0 0.084 11.7 0.7 1.1 1 0 0 1 1 1 0 Cytosol aminopeptidase family, catalytic domain APG6 PF04111.7 EFX03673.1 - 0.82 8.6 9.4 1.4 7.8 6.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 EFX03673.1 - 7.2 6.1 17.3 15 5.1 12.0 1.5 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 EFX03673.1 - 8.9 6.2 19.3 1.5 8.6 10.5 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) GFO_IDH_MocA PF01408.17 EFX03674.1 - 1.4e-22 80.4 0.1 2.3e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EFX03674.1 - 1.2e-07 31.5 0.0 2.7e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.11 EFX03674.1 - 0.00062 20.1 0.2 0.0013 19.1 0.2 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 EFX03674.1 - 0.031 13.2 0.1 0.044 12.7 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase DUF3602 PF12223.3 EFX03675.1 - 2.1e-12 47.2 13.1 1.8e-10 41.0 2.0 2.8 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) F-box-like PF12937.2 EFX03676.1 - 1.3e-06 27.9 0.1 2.5e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX03676.1 - 1.7e-06 27.5 0.1 4.5e-06 26.1 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.1 EFX03676.1 - 1.4e-05 24.7 0.1 4.1e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like domain Gln-synt_C PF00120.19 EFX03677.1 - 3.2e-50 170.6 0.0 4.8e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.9 EFX03677.1 - 7.4e-27 94.5 0.1 2.2e-26 93.0 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Pyr_redox PF00070.22 EFX03678.1 - 3.6e-15 56.1 2.7 1.3e-12 47.9 0.1 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX03678.1 - 9.5e-09 35.4 2.6 0.0067 16.3 0.2 3.6 2 2 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX03678.1 - 2e-06 28.0 0.5 0.045 13.7 0.0 3.4 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX03678.1 - 0.00046 19.2 2.1 0.38 9.6 0.1 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 EFX03678.1 - 0.0019 17.1 0.2 0.0033 16.3 0.1 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 EFX03678.1 - 0.0044 16.1 1.6 1.3 8.0 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 EFX03678.1 - 0.0047 16.9 0.4 1.5 8.8 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX03678.1 - 0.0059 16.3 1.1 5 6.8 0.0 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.1 EFX03678.1 - 0.01 16.1 0.1 0.18 12.0 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.7 EFX03678.1 - 0.018 13.9 1.5 0.03 13.2 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein CBM_10 PF02013.11 EFX03678.1 - 0.14 12.4 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 Cellulose or protein binding domain HI0933_like PF03486.9 EFX03678.1 - 0.25 9.7 2.2 0.87 7.9 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein Trp_halogenase PF04820.9 EFX03678.1 - 0.31 9.6 1.5 15 4.0 0.1 2.9 3 0 0 3 3 3 0 Tryptophan halogenase GIDA PF01134.17 EFX03678.1 - 0.35 9.6 2.4 6.6 5.4 0.2 3.2 3 1 1 4 4 4 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX03678.1 - 2.3 7.1 6.3 2.6 7.0 0.1 2.6 2 1 1 3 3 3 0 FAD dependent oxidoreductase Oxysterol_BP PF01237.13 EFX03679.1 - 7.2e-53 179.3 0.4 1.5e-52 178.2 0.0 1.6 2 0 0 2 2 2 1 Oxysterol-binding protein SET PF00856.23 EFX03679.1 - 8.5e-10 39.1 0.5 3.3e-08 34.0 0.0 3.3 3 1 0 3 3 3 1 SET domain LAM_C PF12544.3 EFX03680.1 - 6.2e-05 23.0 0.0 0.0002 21.4 0.0 1.9 1 0 0 1 1 1 1 Lysine-2,3-aminomutase Radical_SAM PF04055.16 EFX03680.1 - 9.8e-05 22.5 0.0 0.0003 20.9 0.0 1.8 1 1 0 1 1 1 1 Radical SAM superfamily GLTT PF01744.15 EFX03683.1 - 0.00012 21.3 0.6 0.00012 21.3 0.4 1.9 2 0 0 2 2 2 1 GLTT repeat (6 copies) ECH_C PF13766.1 EFX03685.1 - 2.4e-34 118.0 0.0 5.5e-34 116.8 0.0 1.5 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 EFX03685.1 - 4e-23 81.8 0.0 1.6e-22 79.8 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family SR-25 PF10500.4 EFX03685.1 - 0.1 12.0 0.1 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_12 PF13087.1 EFX03686.1 - 5.8e-54 182.5 0.0 9e-54 181.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EFX03686.1 - 6.2e-51 173.2 0.0 9.5e-51 172.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX03686.1 - 1.1e-12 47.4 0.9 1.1e-12 47.4 0.6 3.4 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 EFX03686.1 - 1.3e-11 44.4 5.2 4.6e-09 36.1 0.0 3.8 1 1 1 3 3 3 2 AAA domain Viral_helicase1 PF01443.13 EFX03686.1 - 1.6e-09 37.6 0.5 0.087 12.3 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 EFX03686.1 - 0.00093 18.6 0.1 0.011 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFX03686.1 - 0.0014 18.6 1.8 0.0046 16.9 1.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX03686.1 - 0.0018 18.4 0.0 0.013 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EFX03686.1 - 0.0033 16.8 0.0 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein DUF2075 PF09848.4 EFX03686.1 - 0.0039 16.2 0.1 0.14 11.1 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 EFX03686.1 - 0.0063 16.1 0.0 0.042 13.4 0.0 2.2 2 0 0 2 2 2 1 Helicase TrwB_AAD_bind PF10412.4 EFX03686.1 - 0.0065 15.1 0.0 0.015 13.9 0.0 1.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_10 PF12846.2 EFX03686.1 - 0.0085 15.5 0.0 0.016 14.6 0.0 1.6 1 1 0 1 1 1 1 AAA-like domain UvrD-helicase PF00580.16 EFX03686.1 - 0.01 15.1 0.0 0.019 14.3 0.0 1.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain DEAD PF00270.24 EFX03686.1 - 0.013 14.9 0.0 0.06 12.8 0.0 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA PF00004.24 EFX03686.1 - 0.019 15.1 0.0 0.23 11.6 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFX03686.1 - 0.019 15.7 0.1 0.11 13.3 0.0 2.4 2 1 0 2 2 1 0 AAA domain PIF1 PF05970.9 EFX03686.1 - 0.02 13.8 0.0 0.35 9.7 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase ResIII PF04851.10 EFX03686.1 - 0.044 13.6 0.0 0.11 12.2 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.10 EFX03686.1 - 0.063 12.9 0.3 7.3 6.2 0.1 2.8 2 1 0 2 2 2 0 NTPase UvrD_C_2 PF13538.1 EFX03686.1 - 0.078 13.1 0.2 0.48 10.5 0.0 2.2 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Zot PF05707.7 EFX03686.1 - 0.13 11.7 0.0 0.55 9.6 0.0 2.0 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) TRAPP PF04051.11 EFX03687.1 - 7.1e-36 123.0 0.0 8.3e-36 122.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Actin PF00022.14 EFX03688.1 - 2.6e-129 431.0 0.0 2.9e-129 430.9 0.0 1.0 1 0 0 1 1 1 1 Actin Peptidase_S41 PF03572.13 EFX03689.1 - 0.007 15.7 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S41 Transp_cyt_pur PF02133.10 EFX03690.1 - 1.5e-34 119.3 31.7 3.2e-33 114.9 21.6 2.1 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin RHD3 PF05879.7 EFX03691.1 - 0 1045.5 0.0 0 1045.2 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 EFX03691.1 - 8.5e-10 38.1 0.1 1.4e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 EFX03691.1 - 1.2e-06 28.4 0.0 2.3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 EFX03691.1 - 2.1e-05 24.4 0.0 4.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFX03691.1 - 0.00042 20.7 0.0 0.00082 19.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein AAA_28 PF13521.1 EFX03691.1 - 0.00046 20.1 0.1 0.0019 18.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain Septin PF00735.13 EFX03691.1 - 0.022 13.7 0.1 0.036 13.0 0.1 1.3 1 0 0 1 1 1 0 Septin Cys_Met_Meta_PP PF01053.15 EFX03691.1 - 0.14 10.4 0.2 0.21 9.8 0.1 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF3693 PF12472.3 EFX03691.1 - 4.3 7.0 5.8 1.3 8.6 0.0 2.9 3 0 0 3 3 3 0 Phage related protein Mito_carr PF00153.22 EFX03693.1 - 4.3e-55 183.4 1.9 1e-21 76.4 0.1 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein TAFII55_N PF04658.8 EFX03694.1 - 1e-45 155.1 0.0 1.8e-45 154.3 0.0 1.4 1 0 0 1 1 1 1 TAFII55 protein conserved region GCIP PF13324.1 EFX03694.1 - 0.21 10.7 2.9 0.36 9.9 2.0 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DASH_Hsk3 PF08227.6 EFX03694.1 - 0.57 10.4 2.9 1 9.5 2.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like CybS PF05328.7 EFX03695.1 - 2.7e-48 162.9 0.0 3.5e-48 162.6 0.0 1.1 1 0 0 1 1 1 1 CybS Sdh_cyt PF01127.17 EFX03695.1 - 0.016 15.0 1.1 1.6 8.5 0.1 2.3 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit GFA PF04828.9 EFX03696.1 - 1.7e-20 72.7 0.0 2.5e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.1 EFX03696.1 - 0.13 11.8 1.2 0.3 10.6 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.1 EFX03696.1 - 0.13 11.9 0.1 0.13 11.9 0.0 2.6 3 0 0 3 3 3 0 Nudix N-terminal DZR PF12773.2 EFX03696.1 - 0.15 11.9 1.8 0.28 11.0 0.3 2.1 2 1 0 2 2 2 0 Double zinc ribbon DUF2461 PF09365.5 EFX03697.1 - 4.1e-66 222.4 0.0 5.5e-66 221.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) bZIP_1 PF00170.16 EFX03698.1 - 2.8e-07 30.3 4.2 5.3e-07 29.5 2.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX03698.1 - 0.018 14.8 4.6 0.018 14.8 3.2 1.6 2 0 0 2 2 2 0 Basic region leucine zipper Glutaredoxin2_C PF04399.8 EFX03698.1 - 0.033 13.7 0.7 0.057 12.9 0.5 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Rsa3 PF14615.1 EFX03698.1 - 0.12 11.6 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 Ribosome-assembly protein 3 RNA_pol_Rpb4 PF03874.11 EFX03699.1 - 4.8e-21 74.9 0.0 5.6e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 MFS_1 PF07690.11 EFX03700.1 - 4e-28 98.1 30.6 1.7e-27 96.1 18.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.13 EFX03701.1 - 6.3e-12 44.9 1.8 1.2e-11 44.0 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain AA_permease_2 PF13520.1 EFX03702.1 - 2.9e-63 213.8 45.4 3.6e-63 213.5 31.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX03702.1 - 1.9e-13 49.5 39.8 2.7e-13 49.1 27.6 1.2 1 0 0 1 1 1 1 Amino acid permease adh_short PF00106.20 EFX03703.1 - 4.5e-15 55.9 14.1 4e-13 49.6 9.8 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX03703.1 - 5.6e-09 35.9 1.8 5.6e-09 35.9 1.3 1.8 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 EFX03703.1 - 4.2e-08 33.2 0.1 7.7e-07 29.1 0.1 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 EFX03703.1 - 0.016 14.1 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Methyltransf_26 PF13659.1 EFX03703.1 - 0.028 14.4 2.0 0.045 13.7 1.4 1.5 1 1 0 1 1 1 0 Methyltransferase domain DUF1682 PF07946.9 EFX03704.1 - 1.6e-101 339.3 0.7 1.9e-101 339.1 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF2985 PF11204.3 EFX03704.1 - 0.051 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) Ribosomal_L14 PF00238.14 EFX03705.1 - 1.5e-32 111.9 0.0 1.6e-32 111.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e FAD_binding_8 PF08022.7 EFX03706.1 - 4.4e-23 81.1 0.0 8.4e-23 80.2 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EFX03706.1 - 1.3e-21 77.1 0.0 2.4e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EFX03706.1 - 1.6e-18 67.0 8.3 1.6e-18 67.0 5.8 1.9 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EFX03706.1 - 3e-05 24.0 0.0 0.0001 22.3 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain LrgA PF03788.9 EFX03706.1 - 0.081 12.6 0.1 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 LrgA family NAD_binding_1 PF00175.16 EFX03706.1 - 0.17 12.4 0.0 1.9 9.1 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain WD40 PF00400.27 EFX03707.1 - 6e-70 228.8 15.9 2.9e-12 45.9 0.3 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat GFO_IDH_MocA PF01408.17 EFX03707.1 - 1.6e-17 64.1 0.6 4.1e-17 62.8 0.4 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Nup160 PF11715.3 EFX03707.1 - 1.3e-05 23.5 1.2 0.011 13.8 0.1 3.0 2 1 0 2 2 2 2 Nucleoporin Nup120/160 GFO_IDH_MocA_C PF02894.12 EFX03707.1 - 0.0059 16.3 0.1 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Glucan_synthase PF02364.10 EFX03708.1 - 0 1438.7 0.5 0 1437.6 0.0 1.8 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 EFX03708.1 - 1.4e-38 131.3 0.2 3.5e-38 130.1 0.1 1.7 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Sigma_reg_N PF13800.1 EFX03708.1 - 0.017 15.1 0.3 0.017 15.1 0.2 3.9 5 0 0 5 5 5 0 Sigma factor regulator N-terminal ETF_QO PF05187.8 EFX03710.1 - 1.1e-42 144.5 0.0 1.8e-42 143.7 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 EFX03710.1 - 2.2e-09 36.7 0.1 9.5e-05 21.4 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX03710.1 - 4.8e-08 32.9 0.0 2.9e-07 30.3 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX03710.1 - 1e-05 24.5 0.6 0.0024 16.7 0.3 2.4 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.9 EFX03710.1 - 8.6e-05 22.4 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX03710.1 - 8.8e-05 21.1 0.4 0.00013 20.5 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 EFX03710.1 - 0.00014 21.0 0.0 0.0087 15.1 0.0 2.4 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.2 EFX03710.1 - 0.0002 20.5 0.1 0.00038 19.6 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFX03710.1 - 0.00081 19.1 0.2 0.0018 18.0 0.1 1.7 1 1 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 EFX03710.1 - 0.002 17.2 0.1 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Fer4_7 PF12838.2 EFX03710.1 - 0.0033 17.7 1.1 0.01 16.2 0.7 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Pyr_redox_3 PF13738.1 EFX03710.1 - 0.0039 17.2 0.0 0.0074 16.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX03710.1 - 0.0057 15.3 0.1 0.22 10.1 0.1 2.1 1 1 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.7 EFX03710.1 - 0.018 14.0 0.2 0.027 13.3 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Amino_oxidase PF01593.19 EFX03710.1 - 0.042 12.9 0.0 0.064 12.3 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GIDA PF01134.17 EFX03710.1 - 0.078 11.8 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.22 EFX03710.1 - 0.1 12.9 0.1 5.4 7.4 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.1 EFX03710.1 - 0.12 12.1 1.0 0.26 11.1 0.7 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Gtr1_RagA PF04670.7 EFX03711.1 - 5.8e-68 228.4 0.2 7.1e-68 228.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EFX03711.1 - 0.00054 20.4 0.0 0.011 16.2 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EFX03711.1 - 0.0054 15.9 0.0 0.0076 15.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family NTR2 PF15458.1 EFX03712.1 - 1e-66 224.7 12.8 1.4e-66 224.3 8.8 1.2 1 0 0 1 1 1 1 Nineteen complex-related protein 2 Isochorismatase PF00857.15 EFX03713.1 - 2.5e-23 82.9 0.0 5.4e-23 81.7 0.0 1.5 1 1 0 1 1 1 1 Isochorismatase family CHORD PF04968.7 EFX03714.1 - 3.1e-51 171.5 15.9 8.4e-26 90.0 1.7 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.11 EFX03714.1 - 5.8e-11 42.7 0.0 8.7e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 CS domain Peptidase_S8 PF00082.17 EFX03716.1 - 9e-50 169.3 0.0 2.7e-49 167.8 0.0 1.8 1 1 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 EFX03716.1 - 8.2e-07 29.4 0.1 1.8e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Peripla_BP_1 PF00532.16 EFX03716.1 - 0.057 12.6 0.0 0.56 9.3 0.0 2.0 2 0 0 2 2 2 0 Periplasmic binding proteins and sugar binding domain of LacI family Amidohydro_4 PF13147.1 EFX03717.1 - 2.5e-14 53.9 17.2 5.2e-13 49.6 4.6 2.6 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EFX03717.1 - 2.9e-09 37.0 0.1 2.4e-08 34.0 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EFX03717.1 - 8.2e-09 35.1 1.6 2.7e-07 30.2 0.2 3.3 3 0 0 3 3 3 1 Amidohydrolase Amidohydro_3 PF07969.6 EFX03717.1 - 3.8e-06 26.3 0.1 4.2e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase family Ank_2 PF12796.2 EFX03718.1 - 2.6e-17 62.9 0.9 5.6e-11 42.6 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX03718.1 - 6.5e-16 57.2 9.8 8e-07 28.5 0.9 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 EFX03718.1 - 2.4e-12 47.0 4.0 1.1e-05 25.7 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX03718.1 - 1.3e-09 37.3 3.0 0.00066 19.6 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat DUF3328 PF11807.3 EFX03718.1 - 4.4e-09 36.3 0.9 8.6e-09 35.3 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ank_5 PF13857.1 EFX03718.1 - 1.7e-06 28.0 2.3 0.0015 18.6 0.2 4.1 2 1 1 4 4 4 1 Ankyrin repeats (many copies) Cu_amine_oxid PF01179.15 EFX03718.1 - 2.6e-06 26.4 0.0 4.7e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 EFX03718.1 - 0.037 14.1 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain P16-Arc PF04699.9 EFX03719.1 - 2.8e-54 183.2 0.0 3.3e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) PAP_assoc PF03828.14 EFX03720.1 - 2.7e-17 62.4 0.0 3.7e-11 42.8 0.0 2.5 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EFX03720.1 - 9.4e-05 22.6 0.0 0.00023 21.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_central PF04928.12 EFX03720.1 - 0.066 12.0 0.1 1.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Poly(A) polymerase central domain DWNN PF08783.6 EFX03721.1 - 2.2e-30 104.4 0.0 4.4e-30 103.4 0.0 1.6 1 0 0 1 1 1 1 DWNN domain Med3 PF11593.3 EFX03721.1 - 0.00098 18.4 36.5 0.00098 18.4 25.3 2.4 3 0 0 3 3 2 1 Mediator complex subunit 3 fungal zf-CCHC_2 PF13696.1 EFX03721.1 - 0.0038 16.6 5.3 0.0038 16.6 3.7 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 EFX03721.1 - 0.0092 15.8 1.5 0.0092 15.8 1.0 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-RING_2 PF13639.1 EFX03721.1 - 0.012 15.4 6.3 0.012 15.4 4.4 1.6 2 0 0 2 2 1 0 Ring finger domain zf-RING_5 PF14634.1 EFX03721.1 - 0.013 15.1 7.0 0.013 15.1 4.9 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFX03721.1 - 0.014 15.4 8.1 0.014 15.4 5.6 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-CCHC_3 PF13917.1 EFX03721.1 - 0.019 14.7 0.5 0.054 13.2 0.3 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-C3HC4_4 PF15227.1 EFX03721.1 - 0.03 14.2 10.3 0.081 12.8 7.1 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 EFX03721.1 - 0.031 14.0 1.1 0.053 13.3 0.7 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein U-box PF04564.10 EFX03721.1 - 0.04 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 U-box domain CarboxypepD_reg PF13620.1 EFX03721.1 - 0.061 13.3 2.6 8.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain zf-RING_4 PF14570.1 EFX03721.1 - 0.075 12.6 6.0 0.17 11.4 4.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.20 EFX03721.1 - 0.1 12.3 8.2 0.2 11.3 5.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 EFX03721.1 - 0.11 11.9 4.4 0.23 10.9 3.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS1595 PF12760.2 EFX03721.1 - 1.7 8.5 5.1 7.5 6.4 0.1 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Cullin PF00888.17 EFX03722.1 - 2.3e-52 178.3 0.0 3.6e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Cullin family APC2 PF08672.6 EFX03722.1 - 8.4e-20 70.7 0.9 2.5e-19 69.2 0.1 2.1 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 DUF2418 PF10332.4 EFX03724.1 - 2e-27 95.3 0.1 3.7e-27 94.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) NIF PF03031.13 EFX03725.1 - 1.4e-28 99.5 0.3 2.8e-27 95.3 0.0 2.4 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 EFX03725.1 - 7.8e-08 32.0 0.0 1.7e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EFX03725.1 - 9.9e-06 25.6 0.0 2.9e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Biotin_lipoyl PF00364.17 EFX03725.1 - 0.069 12.7 0.0 2.8 7.6 0.0 2.4 2 0 0 2 2 2 0 Biotin-requiring enzyme XPG_I PF00867.13 EFX03726.1 - 2.9e-25 88.1 0.0 6e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EFX03726.1 - 1.3e-22 79.9 0.0 2.6e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 EFX03726.1 - 9.7e-05 21.9 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.15 EFX03726.1 - 0.0096 16.1 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold TPR_2 PF07719.12 EFX03726.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat PgaD PF13994.1 EFX03727.1 - 0.024 14.1 3.4 0.052 13.0 2.4 1.6 1 0 0 1 1 1 0 PgaD-like protein Methyltransf_32 PF13679.1 EFX03728.1 - 6.5e-19 68.0 0.5 1.8e-18 66.6 0.4 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ecl1 PF12855.2 EFX03729.1 - 8.8e-11 40.9 4.2 1.5e-10 40.1 2.9 1.3 1 0 0 1 1 1 1 Life-span regulatory factor DUF581 PF04570.9 EFX03729.1 - 0.0013 17.9 3.6 0.0024 17.1 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF581) zf-MYND PF01753.13 EFX03729.1 - 0.11 12.3 1.0 0.22 11.4 0.7 1.4 1 0 0 1 1 1 0 MYND finger DUF329 PF03884.9 EFX03729.1 - 0.18 11.3 2.6 0.49 9.9 1.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF329) C1_1 PF00130.17 EFX03729.1 - 0.24 11.1 2.1 0.38 10.5 1.4 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) AA_permease PF00324.16 EFX03730.1 - 2.2e-104 349.4 37.2 1.6e-103 346.6 25.8 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX03730.1 - 2.1e-20 72.6 36.7 2.7e-20 72.3 25.4 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2235 PF09994.4 EFX03731.1 - 2e-59 201.2 0.2 4.4e-56 190.2 0.2 2.1 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Mago-bind PF09282.5 EFX03732.1 - 4.6e-12 45.2 4.2 9.9e-12 44.2 2.9 1.6 1 0 0 1 1 1 1 Mago binding SR-25 PF10500.4 EFX03732.1 - 0.018 14.5 2.6 0.025 14.0 1.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med3 PF11593.3 EFX03732.1 - 3 6.9 6.5 4.4 6.4 4.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MAGE_N PF12440.3 EFX03732.1 - 3.7 7.8 10.1 0.7 10.2 3.9 2.2 2 1 1 3 3 3 0 Melanoma associated antigen family N terminal PfkB PF00294.19 EFX03733.1 - 1.7e-11 43.7 0.0 1.6e-10 40.6 0.0 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase DUF3018 PF11455.3 EFX03733.1 - 0.2 11.6 3.7 0.32 10.9 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3018) IBR PF01485.16 EFX03734.1 - 3.3e-17 62.0 27.6 1.5e-08 34.3 2.0 3.4 3 0 0 3 3 3 2 IBR domain RRM_6 PF14259.1 EFX03734.1 - 5.2e-07 29.5 0.0 0.067 13.1 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.1 EFX03734.1 - 1e-06 28.4 4.8 1e-06 28.4 3.3 4.1 2 1 2 4 4 3 1 Ring finger domain zf-RING_UBOX PF13445.1 EFX03734.1 - 1.2e-05 24.9 1.5 3.7e-05 23.3 1.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 EFX03734.1 - 6.3e-05 22.6 4.2 6.3e-05 22.6 2.9 3.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EFX03734.1 - 0.00014 21.6 5.5 0.00014 21.6 3.8 3.5 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EFX03734.1 - 0.00016 21.6 5.5 0.00016 21.6 3.8 4.4 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX03734.1 - 0.0028 17.2 4.8 0.0028 17.2 3.3 3.7 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) RRM_5 PF13893.1 EFX03734.1 - 0.003 17.3 0.0 0.089 12.6 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 EFX03734.1 - 0.0046 16.5 4.1 0.0046 16.5 2.8 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.17 EFX03734.1 - 0.0078 15.8 0.0 0.07 12.7 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 EFX03735.1 - 0.12 12.2 0.8 4.2 7.4 0.1 2.9 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF4139 PF13598.1 EFX03736.1 - 2e-51 175.1 9.2 2.4e-38 132.2 0.0 3.1 4 0 0 4 4 4 2 Domain of unknown function (DUF4139) DUF4140 PF13600.1 EFX03736.1 - 1.3e-08 35.1 18.0 2.5e-08 34.2 0.0 4.0 1 1 2 4 4 4 2 N-terminal domain of unknown function (DUF4140) CDC37_N PF03234.9 EFX03736.1 - 5.8 7.1 15.7 13 6.1 10.9 1.5 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding AAA_23 PF13476.1 EFX03736.1 - 9.8 6.4 10.6 21 5.3 7.3 1.5 1 0 0 1 1 1 0 AAA domain S1-P1_nuclease PF02265.11 EFX03737.1 - 5.5e-69 232.5 0.1 6.5e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease WD40 PF00400.27 EFX03738.1 - 6.5e-31 105.0 1.7 3.2e-11 42.6 0.1 5.5 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 EFX03738.1 - 0.00086 17.5 0.1 0.0021 16.2 0.0 1.6 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFX03738.1 - 0.00098 17.9 0.1 0.013 14.2 0.0 2.1 1 1 1 2 2 2 1 Nup133 N terminal like Coatomer_WDAD PF04053.9 EFX03738.1 - 0.0012 17.7 0.4 0.19 10.5 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region Lipocalin_6 PF13944.1 EFX03738.1 - 0.11 12.6 1.1 1.1 9.4 0.5 2.3 1 1 1 2 2 2 0 Lipocalin-like domain VTC PF09359.5 EFX03739.1 - 3.6e-98 328.0 0.7 5.1e-98 327.5 0.0 1.6 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 EFX03739.1 - 9.4e-27 94.4 2.9 1.6e-13 51.0 0.8 2.9 2 1 1 3 3 3 2 SPX domain DUF202 PF02656.10 EFX03739.1 - 1.9e-11 44.0 1.3 4.5e-11 42.7 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF202) TrmB PF01978.14 EFX03739.1 - 0.047 13.4 0.1 0.25 11.1 0.1 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF3533 PF12051.3 EFX03740.1 - 2.8e-78 263.3 20.5 3.2e-78 263.1 14.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Cg6151-P PF10233.4 EFX03741.1 - 5.9e-41 138.9 15.0 7.1e-41 138.7 10.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF1430 PF07242.6 EFX03741.1 - 4.5 7.3 9.8 1.8 8.6 4.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) Glutaredoxin PF00462.19 EFX03742.1 - 1.5e-17 63.2 0.0 2.7e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin MIS13 PF08202.6 EFX03743.1 - 2.6e-57 194.2 0.0 4.4e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family ATP-synt_D PF01813.12 EFX03745.1 - 1.4e-63 214.0 2.0 2.2e-63 213.4 1.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit D Sec62 PF03839.11 EFX03745.1 - 2.2 7.6 5.4 3.4 6.9 3.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 ATP-synt_E PF05680.7 EFX03745.1 - 3.2 7.7 8.8 7.6 6.5 6.1 1.6 1 0 0 1 1 1 0 ATP synthase E chain DUF605 PF04652.11 EFX03746.1 - 4.3e-78 263.3 18.1 4e-77 260.1 12.5 1.9 1 1 0 1 1 1 1 Vta1 like Pyr_redox_2 PF07992.9 EFX03747.1 - 4.9e-27 95.1 0.4 7.3e-27 94.5 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX03747.1 - 3.5e-18 65.7 0.9 1.4e-14 54.2 0.1 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX03747.1 - 2.3e-10 40.8 0.2 5.2e-07 29.9 0.0 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX03747.1 - 5.3e-07 28.8 1.5 0.033 13.0 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 EFX03747.1 - 2.8e-05 23.1 0.1 0.0046 15.9 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.1 EFX03747.1 - 3e-05 24.2 0.1 0.018 15.2 0.0 2.6 2 1 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.12 EFX03747.1 - 0.00011 21.3 1.1 0.0011 18.1 0.0 2.7 2 1 1 3 3 3 1 Thi4 family Shikimate_DH PF01488.15 EFX03747.1 - 0.00038 20.5 0.4 0.41 10.7 0.0 2.8 2 1 1 3 3 3 2 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.1 EFX03747.1 - 0.00072 19.5 0.2 0.037 14.0 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EFX03747.1 - 0.0047 16.0 0.4 0.034 13.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 EFX03747.1 - 0.005 15.7 6.2 0.056 12.2 0.2 3.7 3 1 0 4 4 4 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 EFX03747.1 - 0.0073 15.2 4.4 0.027 13.3 0.3 3.0 2 1 0 3 3 3 1 FAD binding domain FAD_binding_3 PF01494.14 EFX03747.1 - 0.014 14.4 0.4 4.1 6.3 0.0 2.7 2 1 1 3 3 3 0 FAD binding domain HI0933_like PF03486.9 EFX03747.1 - 0.016 13.7 0.4 0.8 8.1 0.1 2.9 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_9 PF13454.1 EFX03747.1 - 0.025 14.3 0.1 1.3 8.7 0.0 2.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.9 EFX03747.1 - 0.047 12.3 0.1 0.57 8.7 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Aldedh PF00171.17 EFX03748.1 - 1.1e-07 30.5 12.9 5.4e-05 21.7 6.9 3.0 2 1 0 2 2 2 2 Aldehyde dehydrogenase family F-box-like PF12937.2 EFX03750.1 - 8.3e-06 25.4 0.1 1.7e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX03750.1 - 0.063 12.9 0.2 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 F-box domain HSP70 PF00012.15 EFX03751.1 - 1.3e-269 895.2 14.0 1.5e-269 895.0 9.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFX03751.1 - 2.1e-16 59.4 1.6 9.1e-15 54.0 0.3 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 EFX03751.1 - 0.00026 20.1 2.6 0.015 14.3 0.1 3.2 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase DDR PF08841.5 EFX03751.1 - 0.0081 15.0 0.4 0.058 12.2 0.2 2.0 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.11 EFX03751.1 - 0.084 12.4 0.0 0.57 9.7 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Ribonuclease_T2 PF00445.13 EFX03752.1 - 1.4e-44 152.0 0.5 2.2e-44 151.3 0.4 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family DUF538 PF04398.7 EFX03752.1 - 0.042 14.1 0.0 0.11 12.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF538 RRM_1 PF00076.17 EFX03753.1 - 5.8e-22 77.1 0.1 6.9e-10 38.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03753.1 - 1.3e-12 47.4 0.0 3.6e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03753.1 - 1.6e-12 47.0 0.0 1.5e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EamA PF00892.15 EFX03754.1 - 1.4e-20 73.5 20.7 4.1e-12 46.2 2.1 3.5 2 2 2 4 4 4 2 EamA-like transporter family EmrE PF13536.1 EFX03754.1 - 0.00027 21.1 18.7 0.00031 20.9 0.4 3.3 3 0 0 3 3 3 2 Multidrug resistance efflux transporter UAA PF08449.6 EFX03754.1 - 1.4 7.7 9.0 3.2 6.5 1.2 2.2 2 0 0 2 2 2 0 UAA transporter family Aft1_HRA PF11786.3 EFX03755.1 - 7.2e-25 87.0 10.8 7.2e-25 87.0 7.5 3.2 4 0 0 4 4 4 1 Aft1 HRA domain Aft1_OSA PF11785.3 EFX03755.1 - 2.1e-16 60.1 10.0 2.1e-16 60.1 6.9 4.1 5 0 0 5 5 5 1 Aft1 osmotic stress response (OSM) domain Aft1_HRR PF11787.3 EFX03755.1 - 1.2e-14 55.0 10.6 1.2e-14 55.0 7.4 4.7 4 1 0 4 4 4 1 Aft1 HRR domain bZIP_1 PF00170.16 EFX03755.1 - 9.1e-13 47.9 5.6 1.8e-12 47.0 3.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX03755.1 - 3.4e-07 29.9 5.0 7e-07 28.9 3.4 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EFX03755.1 - 0.0024 18.1 2.5 0.0024 18.1 1.7 1.9 1 1 1 2 2 2 1 bZIP Maf transcription factor Abhydrolase_3 PF07859.8 EFX03757.1 - 4.2e-50 170.2 3.7 6.8e-44 149.9 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFX03757.1 - 6.2e-07 28.8 0.0 2.1e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFX03757.1 - 7.5e-07 29.2 0.7 1.4e-06 28.3 0.5 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX03757.1 - 0.00026 20.7 0.0 0.00047 19.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 EFX03757.1 - 0.00034 19.4 3.7 0.0019 16.9 2.6 2.0 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.4 EFX03757.1 - 0.00072 18.8 0.1 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase DLH PF01738.13 EFX03757.1 - 0.11 11.7 0.0 0.36 10.0 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Mog1 PF04603.7 EFX03758.1 - 3.3e-22 78.9 0.0 4.2e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Methyltransf_23 PF13489.1 EFX03759.1 - 1.8e-09 37.5 0.0 2.6e-09 36.9 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03759.1 - 0.00038 20.8 0.0 0.00074 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03759.1 - 0.02 15.3 0.0 0.15 12.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain PhyH PF05721.8 EFX03760.1 - 1.9e-35 122.8 0.2 2.9e-35 122.2 0.2 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) RhoGAP PF00620.22 EFX03761.1 - 1.4e-10 40.9 0.0 4.1e-10 39.4 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain Fungal_trans PF04082.13 EFX03764.1 - 1.6e-15 56.6 0.2 2.5e-15 56.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFX03764.1 - 7.4e-11 41.7 10.3 1e-05 25.5 2.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX03764.1 - 4.3e-09 36.0 11.1 7.3e-05 22.8 3.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX03764.1 - 3.5e-08 33.3 6.8 2.4e-05 24.3 1.7 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 EFX03764.1 - 0.00042 20.1 5.1 0.08 12.8 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 EFX03764.1 - 0.0017 17.9 2.6 0.0017 17.9 1.8 1.7 2 0 0 2 2 2 1 zinc-finger of a C2HC-type Lar_restr_allev PF14354.1 EFX03764.1 - 0.023 14.9 0.2 0.047 14.0 0.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-C2H2_jaz PF12171.3 EFX03764.1 - 0.042 13.9 2.5 0.042 13.9 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-RING_3 PF14369.1 EFX03764.1 - 0.24 11.4 3.0 3.1 7.8 0.1 2.5 2 0 0 2 2 2 0 zinc-finger Zn_Tnp_IS1595 PF12760.2 EFX03764.1 - 0.58 10.0 4.0 1.2 8.9 2.8 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.5 EFX03764.1 - 0.87 9.5 4.0 3.1 7.8 0.3 2.3 1 1 0 2 2 2 0 Zinc ribbon domain ATP-grasp_4 PF13535.1 EFX03765.1 - 1.2e-16 60.9 0.0 2.1e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFX03765.1 - 6.2e-12 45.3 0.0 1.2e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.12 EFX03765.1 - 5.1e-05 22.6 0.0 9.7e-05 21.7 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.9 EFX03765.1 - 8.7e-05 22.4 0.0 0.00031 20.6 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EFX03765.1 - 0.0018 17.1 0.0 0.3 9.7 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.14 EFX03765.1 - 0.0042 16.6 0.0 0.006 16.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ApbA_C PF08546.6 EFX03765.1 - 0.014 15.4 0.0 0.045 13.7 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal Methyltransf_23 PF13489.1 EFX03766.1 - 5.6e-16 58.6 0.0 8.4e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03766.1 - 2.4e-11 43.9 0.0 9.5e-11 42.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03766.1 - 1.5e-06 28.5 0.0 0.00012 22.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03766.1 - 1.9e-06 28.4 0.0 0.00075 20.0 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX03766.1 - 0.00028 20.0 0.0 0.064 12.3 0.0 2.2 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFX03766.1 - 0.00086 18.9 0.0 0.15 11.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EFX03766.1 - 0.008 15.5 0.0 0.031 13.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFX03766.1 - 0.014 15.7 0.0 0.29 11.4 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.13 EFX03766.1 - 0.026 13.7 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_8 PF05148.10 EFX03766.1 - 0.035 13.7 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase FtsJ PF01728.14 EFX03766.1 - 0.14 12.1 0.0 0.41 10.5 0.0 1.8 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_PK PF05891.7 EFX03766.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase ABC_tran PF00005.22 EFX03767.1 - 8.5e-54 181.5 0.0 1.7e-29 102.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFX03767.1 - 7.5e-40 137.0 27.2 2.4e-20 73.0 8.2 3.9 3 1 0 3 3 3 3 ABC transporter transmembrane region AAA_21 PF13304.1 EFX03767.1 - 1.7e-09 38.0 0.0 0.018 15.0 0.0 4.3 3 1 1 4 4 4 2 AAA domain SMC_N PF02463.14 EFX03767.1 - 2.1e-09 36.9 0.9 0.0026 17.0 0.0 4.0 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EFX03767.1 - 4.4e-09 36.9 0.0 1.3e-05 25.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFX03767.1 - 2.3e-06 27.1 0.0 0.084 12.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EFX03767.1 - 3.8e-06 26.3 0.3 0.06 12.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EFX03767.1 - 1.6e-05 25.0 0.2 0.37 10.7 0.1 3.1 2 1 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 EFX03767.1 - 1.8e-05 24.0 0.0 0.15 11.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 EFX03767.1 - 4.8e-05 22.4 0.0 0.0068 15.3 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_17 PF13207.1 EFX03767.1 - 0.00013 22.7 0.0 1.2 9.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 EFX03767.1 - 0.00017 21.0 0.0 0.17 11.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein MMR_HSR1 PF01926.18 EFX03767.1 - 0.00025 20.9 1.6 0.064 13.2 0.0 3.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_10 PF12846.2 EFX03767.1 - 0.0003 20.3 0.0 0.62 9.4 0.0 2.8 2 0 0 2 2 2 2 AAA-like domain AAA_22 PF13401.1 EFX03767.1 - 0.00031 20.8 0.1 0.88 9.7 0.0 3.4 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 EFX03767.1 - 0.00069 19.3 0.1 1.1 8.9 0.0 2.9 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 EFX03767.1 - 0.00073 18.6 1.1 0.65 9.0 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin FtsK_SpoIIIE PF01580.13 EFX03767.1 - 0.00079 18.9 0.2 1.3 8.4 0.0 2.7 3 0 0 3 3 3 2 FtsK/SpoIIIE family AAA_18 PF13238.1 EFX03767.1 - 0.00098 19.4 0.1 1.1 9.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 EFX03767.1 - 0.0018 18.7 0.3 3.6 8.0 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein DUF87 PF01935.12 EFX03767.1 - 0.0039 17.0 1.3 0.23 11.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA PF00004.24 EFX03767.1 - 0.0054 16.9 0.3 5.3 7.2 0.0 3.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFX03767.1 - 0.009 15.7 0.5 0.28 10.9 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain Dynamin_N PF00350.18 EFX03767.1 - 0.023 14.5 0.6 3.1 7.5 0.0 3.0 3 0 0 3 3 2 0 Dynamin family AAA_33 PF13671.1 EFX03767.1 - 0.03 14.1 0.1 8.5 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 EFX03767.1 - 0.044 13.9 0.1 17 5.6 0.0 2.8 2 0 0 2 2 2 0 RNA helicase Pox_A32 PF04665.7 EFX03767.1 - 0.047 12.9 0.3 1.5 8.0 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein DUF2075 PF09848.4 EFX03767.1 - 0.053 12.4 0.2 6.1 5.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 EFX03767.1 - 0.053 13.3 0.0 15 5.3 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Arch_ATPase PF01637.13 EFX03767.1 - 0.058 13.0 0.1 0.25 10.9 0.0 2.0 2 0 0 2 2 2 0 Archaeal ATPase NACHT PF05729.7 EFX03767.1 - 0.11 12.1 2.3 2.4 7.8 0.2 2.7 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.9 EFX03767.1 - 0.18 11.5 0.8 20 4.8 0.1 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.14 EFX03767.1 - 0.5 9.7 3.8 0.55 9.6 0.5 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_15 PF13175.1 EFX03767.1 - 0.68 8.9 0.0 1.8 7.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain PDZ PF00595.19 EFX03769.1 - 0.081 13.1 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) UDPGP PF01704.13 EFX03770.1 - 6.6e-46 156.6 0.0 8.9e-46 156.2 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 EFX03770.1 - 0.046 13.7 3.1 0.057 13.5 0.1 2.2 1 1 1 2 2 2 0 MobA-like NTP transferase domain Isochorismatase PF00857.15 EFX03771.1 - 4.4e-28 98.3 0.1 9e-28 97.3 0.0 1.6 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans PF04082.13 EFX03771.1 - 4.5e-17 61.7 0.1 7.8e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03771.1 - 0.012 15.4 7.6 0.012 15.4 5.2 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1906 PF08924.6 EFX03771.1 - 0.087 12.6 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) Epimerase PF01370.16 EFX03772.1 - 4.5e-09 36.1 0.4 1.4e-08 34.5 0.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX03772.1 - 1.4e-06 28.3 0.4 6.5e-06 26.2 0.3 2.1 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EFX03772.1 - 0.0037 16.2 0.1 0.015 14.2 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein RRM_1 PF00076.17 EFX03773.1 - 1.7e-15 56.4 0.0 2.9e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX03773.1 - 7.5e-14 51.4 0.0 1.1e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX03773.1 - 4.5e-05 23.2 0.0 7.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 EFX03773.1 - 0.0013 19.0 1.4 0.0013 19.0 1.0 2.9 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 FAM74 PF15026.1 EFX03773.1 - 0.075 12.6 0.2 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 FAM74 protein Fucose_iso_N2 PF07882.7 EFX03774.1 - 0.098 12.2 0.1 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain DUF3433 PF11915.3 EFX03775.1 - 6.8e-42 141.5 17.0 2.8e-24 85.0 0.9 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) DUF457 PF04307.9 EFX03775.1 - 0.51 9.6 7.6 0.024 13.9 0.6 2.2 2 1 0 2 2 2 0 Predicted membrane-bound metal-dependent hydrolase (DUF457) zf-UBR PF02207.15 EFX03776.1 - 1.5e-16 59.8 16.1 1.5e-16 59.8 11.2 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 EFX03776.1 - 3e-07 30.0 0.1 8.5e-07 28.6 0.0 1.8 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS FAD_binding_4 PF01565.18 EFX03777.1 - 2.8e-23 81.9 0.9 5.9e-23 80.8 0.6 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX03777.1 - 3.2e-05 23.7 0.0 7.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF3572 PF12096.3 EFX03778.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) FPN1 PF06963.7 EFX03779.1 - 1.9e-114 382.4 21.2 2.6e-114 381.9 14.7 1.2 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Abhydrolase_6 PF12697.2 EFX03779.1 - 2.1e-16 60.5 5.3 2.1e-16 60.5 3.7 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX03779.1 - 2.9e-15 56.2 0.5 7.3e-15 54.9 0.3 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFX03779.1 - 1.2e-08 34.8 0.4 2.1e-08 34.0 0.3 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 EFX03779.1 - 0.00012 21.7 0.5 0.0007 19.2 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.15 EFX03779.1 - 0.002 18.4 0.7 0.003 17.8 0.1 1.6 2 0 0 2 2 2 1 Thioesterase domain Peptidase_S9 PF00326.16 EFX03779.1 - 0.0021 17.3 0.0 0.0042 16.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family GRIM-19 PF06212.7 EFX03780.1 - 1.3e-22 79.8 0.0 2.5e-22 78.9 0.0 1.4 1 1 0 1 1 1 1 GRIM-19 protein CSD PF00313.17 EFX03781.1 - 2.7e-18 65.5 0.4 2.9e-18 65.3 0.2 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 EFX03781.1 - 0.11 11.9 0.2 0.17 11.3 0.2 1.3 1 0 0 1 1 1 0 Ribonuclease B OB domain DUF3638 PF12340.3 EFX03783.1 - 4.9e-90 300.5 0.1 8.8e-90 299.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 EFX03783.1 - 6.5e-17 60.3 0.1 2e-16 58.7 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Nucleoplasmin PF03066.10 EFX03784.1 - 0.0066 15.9 1.3 0.0066 15.9 0.9 1.5 2 0 0 2 2 2 1 Nucleoplasmin Sigma70_ner PF04546.8 EFX03784.1 - 0.011 15.3 1.6 0.044 13.3 0.2 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF4611 PF15387.1 EFX03784.1 - 0.036 14.2 1.5 0.036 14.2 1.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) RXT2_N PF08595.6 EFX03784.1 - 0.24 11.1 4.1 0.34 10.7 0.9 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal SR-25 PF10500.4 EFX03784.1 - 0.43 10.0 16.3 0.92 8.9 11.3 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SRC-1 PF08832.5 EFX03784.1 - 0.43 11.3 8.0 0.11 13.2 1.7 2.4 2 0 0 2 2 2 0 Steroid receptor coactivator PBP1_TM PF14812.1 EFX03784.1 - 1.5 9.2 9.3 3 8.2 5.0 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.4 EFX03784.1 - 1.6 7.3 19.4 0.49 9.0 5.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) FAM176 PF14851.1 EFX03784.1 - 1.7 8.3 7.1 2.1 8.0 1.1 2.3 2 0 0 2 2 2 0 FAM176 family TraG-D_C PF12696.2 EFX03784.1 - 1.8 8.4 5.0 10 5.9 2.4 2.2 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG BUD22 PF09073.5 EFX03784.1 - 2.5 7.1 9.0 6.4 5.7 0.1 2.1 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.7 EFX03784.1 - 2.6 7.6 15.7 0.69 9.5 1.3 2.5 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 EFX03784.1 - 3 5.7 8.2 2.1 6.2 1.1 2.1 2 0 0 2 2 2 0 CDC45-like protein Pap_E4 PF02711.9 EFX03784.1 - 8.9 7.2 6.7 3.3 8.5 1.1 2.7 2 0 0 2 2 2 0 E4 protein Nup96 PF12110.3 EFX03785.1 - 5.5e-73 245.6 0.0 7.8e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 EFX03785.1 - 7.8e-40 135.9 0.0 1.3e-39 135.2 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 EFX03785.1 - 5.5e-17 62.0 299.1 4.2e-07 30.1 34.6 10.0 4 1 4 8 8 8 5 Nucleoporin FG repeat region TMEM37 PF15108.1 EFX03787.1 - 0.033 13.9 0.3 0.059 13.0 0.2 1.4 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family GST_N_2 PF13409.1 EFX03788.1 - 1.1e-20 73.3 0.0 3.2e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFX03788.1 - 4.8e-15 55.2 0.1 8.9e-15 54.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFX03788.1 - 3.4e-06 27.1 0.0 0.00044 20.4 0.0 2.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFX03788.1 - 2.1e-05 24.3 0.0 4.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFX03788.1 - 0.0016 18.8 0.0 0.005 17.2 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Glyco_hydro_2_N PF02837.13 EFX03788.1 - 0.01 15.3 0.2 0.019 14.5 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain Ald_Xan_dh_C2 PF02738.13 EFX03788.1 - 0.18 10.0 0.0 0.28 9.4 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase SNF2_N PF00176.18 EFX03790.1 - 4.3e-82 275.2 0.1 7.8e-82 274.4 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 EFX03790.1 - 4.9e-44 148.8 3.0 1.1e-43 147.6 2.1 1.7 1 0 0 1 1 1 1 SLIDE HAND PF09110.6 EFX03790.1 - 1.4e-27 96.3 2.1 1.4e-27 96.3 1.4 3.4 3 0 0 3 3 3 1 HAND Helicase_C PF00271.26 EFX03790.1 - 7.1e-15 54.6 0.0 2.9e-14 52.6 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX03790.1 - 7.5e-09 35.6 0.0 4.2e-08 33.2 0.0 2.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFX03790.1 - 1.3e-05 24.7 0.0 3.1e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.10 EFX03790.1 - 0.015 14.7 0.0 0.035 13.4 0.0 1.6 1 0 0 1 1 1 0 DEAD_2 GFA PF04828.9 EFX03791.1 - 8.7e-05 22.3 1.1 9.7e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme HD-ZIP_N PF04618.7 EFX03791.1 - 0.15 12.6 0.0 1.4 9.4 0.0 2.0 1 1 1 2 2 2 0 HD-ZIP protein N terminus MFS_1 PF07690.11 EFX03793.1 - 5.7e-43 146.9 64.9 5.7e-40 137.1 45.0 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX03793.1 - 1.5e-16 60.0 14.6 1.5e-16 60.0 10.1 3.6 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 EFX03793.1 - 2.9e-15 55.5 19.0 2.9e-15 55.5 13.2 1.6 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) RED_N PF07808.8 EFX03794.1 - 2e-09 37.0 6.2 2e-09 37.0 4.3 2.8 3 0 0 3 3 3 1 RED-like protein N-terminal region DUF2217 PF10265.4 EFX03794.1 - 5.7 5.5 15.2 0.14 10.9 5.7 1.7 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2217) RTA1 PF04479.8 EFX03796.1 - 1.2e-09 37.9 1.7 6.4e-08 32.3 0.1 2.2 1 1 1 2 2 2 2 RTA1 like protein zf-C2H2 PF00096.21 EFX03797.1 - 1.2e-10 41.0 18.4 2.3e-06 27.6 1.5 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX03797.1 - 6.5e-07 29.2 21.7 5.9e-05 23.1 3.3 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX03797.1 - 6.7e-07 29.2 13.4 4.1e-05 23.6 4.7 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EFX03797.1 - 1.9e-05 24.6 6.8 0.0013 18.8 0.6 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX03797.1 - 2.2e-05 24.4 5.8 0.00023 21.2 0.2 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EFX03797.1 - 0.075 12.9 10.2 0.3 11.0 0.8 3.2 2 1 0 2 2 2 0 C2H2-type zinc finger DUF4636 PF15468.1 EFX03797.1 - 0.082 12.3 8.1 0.13 11.6 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Elf1 PF05129.8 EFX03797.1 - 1.7 8.4 5.1 8.8 6.1 0.8 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like NUDIX PF00293.23 EFX03798.1 - 2.5e-07 30.4 0.0 6.5e-07 29.0 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain DAHP_synth_2 PF01474.11 EFX03799.1 - 2.9e-190 632.2 0.0 3.3e-190 632.0 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Rep_fac-A_C PF08646.5 EFX03800.1 - 1.8e-53 180.1 0.3 1.1e-51 174.4 0.1 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain Rep-A_N PF04057.7 EFX03800.1 - 2.5e-20 72.1 0.0 4.8e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.20 EFX03800.1 - 9e-17 60.7 1.3 3.7e-12 45.9 0.0 4.1 4 1 0 4 4 4 3 OB-fold nucleic acid binding domain FAD_binding_4 PF01565.18 EFX03801.1 - 2e-18 66.2 2.1 6e-18 64.6 1.5 1.9 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX03801.1 - 0.00026 20.8 0.0 0.00056 19.7 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like OMPdecase PF00215.19 EFX03802.1 - 1.3e-86 289.7 0.0 1.5e-86 289.4 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family F-box-like PF12937.2 EFX03804.1 - 0.004 16.8 0.1 0.0089 15.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like Glyco_tranf_2_3 PF13641.1 EFX03805.1 - 5.3e-21 75.4 0.0 1.2e-20 74.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFX03805.1 - 1.7e-11 44.2 13.0 2.8e-11 43.4 3.5 2.4 2 0 0 2 2 2 2 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 EFX03805.1 - 0.0015 18.1 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EFX03805.1 - 0.004 16.4 0.0 0.0083 15.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Pkinase PF00069.20 EFX03808.1 - 9.6e-59 198.6 0.0 2.6e-58 197.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03808.1 - 1.9e-22 79.5 0.0 2.9e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFX03808.1 - 0.0058 16.4 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RWD PF05773.17 EFX03809.1 - 2.6e-20 72.3 0.0 4.4e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain CDC37_N PF03234.9 EFX03809.1 - 5.6 7.2 7.9 1.8 8.8 0.7 2.3 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding SAP PF02037.22 EFX03812.1 - 2.9e-08 32.9 2.1 3.5e-08 32.7 0.3 2.1 2 0 0 2 2 2 1 SAP domain zf-C3HC4 PF00097.20 EFX03812.1 - 3.8e-08 32.8 10.2 3.8e-08 32.8 7.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX03812.1 - 1.2e-07 31.6 14.4 1.5e-07 31.3 7.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX03812.1 - 9.3e-07 28.4 11.5 2.1e-06 27.3 5.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX03812.1 - 1.2e-06 28.1 9.8 1.2e-06 28.1 6.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 EFX03812.1 - 1.3e-06 28.1 14.9 1.7e-06 27.7 6.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.1 EFX03812.1 - 3.4e-05 23.5 2.6 3.4e-05 23.5 1.8 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 EFX03812.1 - 3.8e-05 23.4 9.8 3.8e-05 23.4 6.8 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Mob_synth_C PF06463.8 EFX03812.1 - 0.0027 17.4 3.6 0.0066 16.1 2.5 1.7 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C zf-rbx1 PF12678.2 EFX03812.1 - 0.0029 17.6 4.7 0.0029 17.6 3.2 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger U-box PF04564.10 EFX03812.1 - 0.0067 16.3 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_4 PF14570.1 EFX03812.1 - 0.0068 15.9 2.0 0.0068 15.9 1.4 2.8 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 EFX03812.1 - 0.0084 15.8 8.0 0.0084 15.8 5.5 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-Apc11 PF12861.2 EFX03812.1 - 0.063 13.1 2.8 0.17 11.7 1.9 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.9 EFX03812.1 - 0.65 9.5 12.0 0.23 10.9 4.4 2.3 2 0 0 2 2 2 0 P-11 zinc finger Ribosomal_L44 PF00935.14 EFX03813.1 - 4.8e-34 116.1 12.3 7.4e-34 115.6 8.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 DUF2652 PF10851.3 EFX03813.1 - 0.58 10.1 2.6 0.28 11.1 0.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2652) HET PF06985.6 EFX03814.1 - 1e-13 51.6 0.1 9.1e-07 29.1 0.0 3.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.18 EFX03815.1 - 1.3e-76 257.3 0.0 6e-76 255.0 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX03815.1 - 7.8e-09 35.2 0.0 1.6e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFX03815.1 - 2.1e-06 27.3 0.0 4.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.10 EFX03815.1 - 0.00041 19.7 0.0 0.00085 18.7 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.10 EFX03815.1 - 0.0005 19.9 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1777 PF08648.7 EFX03816.1 - 0.01 15.5 13.5 0.01 15.5 9.3 6.3 3 3 2 6 6 6 0 Protein of unknown function (DUF1777) Anp1 PF03452.9 EFX03817.1 - 4e-121 403.3 0.0 1.4e-120 401.5 0.0 1.7 2 0 0 2 2 2 1 Anp1 MFS_1 PF07690.11 EFX03818.1 - 9.1e-47 159.4 41.0 9.1e-47 159.4 28.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX03818.1 - 1.1e-11 44.0 10.7 1.1e-11 44.0 7.4 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter ATP-synt_F PF01990.12 EFX03819.1 - 6.6e-32 109.7 0.1 7.7e-32 109.5 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit RNA_pol_Rpb8 PF03870.10 EFX03820.1 - 1.6e-32 112.5 0.0 1.8e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 APH PF01636.18 EFX03821.1 - 1e-16 61.4 0.0 4.8e-16 59.2 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFX03821.1 - 2.4e-05 23.6 0.0 3.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 EFX03821.1 - 3.3e-05 22.7 0.0 4.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.15 EFX03821.1 - 0.038 13.5 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Methyltransf_31 PF13847.1 EFX03822.1 - 3.6e-13 49.3 0.0 4.7e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03822.1 - 1.2e-10 41.6 0.0 3.8e-10 40.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03822.1 - 5.9e-09 36.5 0.0 9.4e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03822.1 - 7.5e-09 35.9 0.0 1.2e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX03822.1 - 7.2e-08 32.3 0.0 1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX03822.1 - 1.2e-06 27.9 0.0 1.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFX03822.1 - 1.5e-06 28.5 0.0 2.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EFX03822.1 - 2.7e-06 27.0 0.0 4.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 EFX03822.1 - 7.1e-06 26.0 0.3 1.6e-05 24.9 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 EFX03822.1 - 0.001 18.2 0.1 0.0015 17.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.15 EFX03822.1 - 0.0012 17.9 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.1 EFX03822.1 - 0.0021 17.7 0.0 0.0029 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX03822.1 - 0.003 16.7 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family UPF0020 PF01170.13 EFX03822.1 - 0.022 14.3 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_9 PF08003.6 EFX03822.1 - 0.045 12.4 0.0 0.057 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.15 EFX03822.1 - 0.093 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.12 EFX03822.1 - 0.19 10.7 0.0 0.32 10.0 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase DUF1749 PF08538.5 EFX03823.1 - 9.4e-85 284.1 0.0 1.1e-84 283.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 EFX03823.1 - 7.5e-13 48.8 0.0 9.7e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX03823.1 - 1.9e-06 27.6 0.0 5.2e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX03823.1 - 0.031 13.8 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.15 EFX03823.1 - 0.045 13.2 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold ATG22 PF11700.3 EFX03824.1 - 0.024 13.1 0.4 0.033 12.6 0.3 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like SCF PF02404.10 EFX03824.1 - 0.32 10.1 1.2 0.42 9.7 0.8 1.1 1 0 0 1 1 1 0 Stem cell factor Cys_Met_Meta_PP PF01053.15 EFX03825.1 - 6e-137 456.0 0.0 7.1e-137 455.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EFX03825.1 - 1.1e-05 24.5 0.0 1.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFX03825.1 - 2.3e-05 23.3 0.0 4.5e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V GDC-P PF02347.11 EFX03825.1 - 0.00015 20.6 0.1 0.00024 19.9 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein DegT_DnrJ_EryC1 PF01041.12 EFX03825.1 - 0.0015 17.6 0.0 0.0036 16.3 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EFX03825.1 - 0.0021 17.2 0.2 0.008 15.3 0.1 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase POTRA_2 PF08479.6 EFX03825.1 - 0.013 15.1 0.0 0.036 13.7 0.0 1.7 1 0 0 1 1 1 0 POTRA domain, ShlB-type E1_DerP2_DerF2 PF02221.10 EFX03826.1 - 2.6e-25 89.2 0.2 3e-25 88.9 0.1 1.1 1 0 0 1 1 1 1 ML domain CAV_VP3 PF04771.7 EFX03827.1 - 0.082 12.8 0.2 0.094 12.6 0.1 1.2 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein MFS_2 PF13347.1 EFX03828.1 - 2.2e-06 26.3 0.0 2.2e-06 26.3 0.0 3.1 2 1 1 3 3 3 1 MFS/sugar transport protein DUF4064 PF13273.1 EFX03828.1 - 0.027 14.5 0.5 0.15 12.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF2116 PF09889.4 EFX03828.1 - 0.027 14.2 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Shikimate_DH PF01488.15 EFX03829.1 - 0.065 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RNase_HII PF01351.13 EFX03830.1 - 8.8e-31 107.0 0.0 1.2e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII Ion_trans PF00520.26 EFX03831.1 - 2.1e-07 30.4 5.9 3.7e-07 29.6 4.1 1.4 1 0 0 1 1 1 1 Ion transport protein DivIC PF04977.10 EFX03831.1 - 0.0029 17.0 0.5 0.0061 16.0 0.4 1.6 1 0 0 1 1 1 1 Septum formation initiator DUF948 PF06103.6 EFX03831.1 - 0.011 15.5 0.2 0.011 15.5 0.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF485 PF04341.7 EFX03831.1 - 0.072 12.8 2.6 0.14 11.8 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF3373 PF11853.3 EFX03831.1 - 0.093 11.2 0.5 0.11 10.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) HALZ PF02183.13 EFX03831.1 - 0.11 12.2 1.8 0.17 11.6 1.3 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Spc24 PF08286.6 EFX03831.1 - 0.54 9.9 2.6 0.7 9.6 1.6 1.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 bZIP_1 PF00170.16 EFX03831.1 - 4.9 7.1 8.6 0.18 11.8 1.6 1.7 2 0 0 2 2 2 0 bZIP transcription factor WD40 PF00400.27 EFX03833.1 - 4.1e-47 156.4 27.8 2.6e-11 42.9 0.1 11.4 12 0 0 12 12 12 7 WD domain, G-beta repeat Utp12 PF04003.7 EFX03833.1 - 6.2e-27 93.6 0.0 9.4e-27 93.1 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.6 EFX03833.1 - 9.7e-06 25.4 2.1 0.075 12.7 0.0 4.8 5 2 1 6 6 6 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EFX03833.1 - 0.071 11.2 8.5 4.2 5.3 0.0 4.4 2 1 2 5 5 5 0 Nucleoporin Nup120/160 DUF1195 PF06708.6 EFX03833.1 - 0.082 12.3 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) IKI3 PF04762.7 EFX03833.1 - 0.21 9.3 0.0 9.7 3.8 0.0 2.2 2 0 0 2 2 2 0 IKI3 family HEAT PF02985.17 EFX03834.1 - 4.4e-10 38.7 0.8 0.061 13.4 0.0 5.5 5 0 0 5 5 5 3 HEAT repeat Pkinase_Tyr PF07714.12 EFX03834.1 - 1.5e-08 34.0 0.0 2.8e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 EFX03834.1 - 6.2e-08 32.0 0.0 1.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HEAT_EZ PF13513.1 EFX03834.1 - 0.00012 22.4 0.0 1.1 9.8 0.0 3.2 2 0 0 2 2 2 2 HEAT-like repeat Cnd1 PF12717.2 EFX03834.1 - 0.0021 17.9 0.0 0.0056 16.5 0.0 1.6 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFX03834.1 - 0.0033 17.6 0.0 0.074 13.3 0.0 3.0 1 1 1 2 2 2 2 HEAT repeats Kinase-like PF14531.1 EFX03834.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF4098 PF13345.1 EFX03835.1 - 7.7e-07 28.9 8.2 0.089 12.7 0.0 5.7 4 1 0 5 5 5 5 Domain of unknown function (DUF4098) ADH_N PF08240.7 EFX03836.1 - 3.5e-26 91.1 4.2 6.2e-26 90.2 2.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX03836.1 - 2.9e-19 68.9 0.1 5.5e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX03836.1 - 3.4e-05 24.7 0.0 6.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFX03836.1 - 0.00063 18.9 0.1 0.001 18.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFX03836.1 - 0.0055 16.7 0.0 0.0085 16.1 0.0 1.4 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.17 EFX03836.1 - 0.14 12.6 0.0 0.32 11.5 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Glycos_transf_4 PF00953.16 EFX03837.1 - 4.1e-24 85.1 11.5 4.1e-24 85.1 8.0 2.2 1 1 1 2 2 2 1 Glycosyl transferase family 4 Asp PF00026.18 EFX03838.1 - 1e-65 222.0 11.0 1.2e-65 221.8 7.6 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX03838.1 - 3e-07 30.5 0.2 2.7e-06 27.4 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal ORMDL PF04061.9 EFX03839.1 - 3.1e-60 201.6 3.4 3.7e-60 201.3 2.4 1.1 1 0 0 1 1 1 1 ORMDL family PP28 PF10252.4 EFX03840.1 - 2e-22 79.0 22.0 2e-22 79.0 15.2 3.4 2 2 1 3 3 3 1 Casein kinase substrate phosphoprotein PP28 MlrC_C PF07171.7 EFX03840.1 - 0.01 15.3 0.7 0.017 14.6 0.5 1.4 1 0 0 1 1 1 0 MlrC C-terminus Clat_adaptor_s PF01217.15 EFX03841.1 - 2.5e-51 173.1 0.9 3.5e-51 172.6 0.7 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Methyltransf_11 PF08241.7 EFX03842.1 - 3.7e-12 46.5 0.0 7.2e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX03842.1 - 1.2e-11 44.5 0.0 1.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03842.1 - 9.5e-09 35.0 0.0 5.4e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03842.1 - 9e-08 32.6 0.0 1.4e-06 28.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03842.1 - 2.3e-07 31.2 0.0 2.1e-06 28.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX03842.1 - 6.7e-05 22.1 0.0 0.00083 18.5 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 EFX03842.1 - 0.00072 19.5 0.0 0.0013 18.8 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 EFX03842.1 - 0.0034 16.4 0.0 0.013 14.5 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_25 PF13649.1 EFX03842.1 - 0.0052 17.1 0.0 0.014 15.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EFX03842.1 - 0.047 13.3 0.0 0.47 10.0 0.0 2.1 1 1 0 1 1 1 0 Hypothetical methyltransferase MTS PF05175.9 EFX03842.1 - 0.051 12.9 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.4 EFX03842.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_PK PF05891.7 EFX03842.1 - 0.11 11.7 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase vWF_A PF12450.3 EFX03842.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor CAP_GLY PF01302.20 EFX03843.1 - 1.5e-18 66.2 0.6 3.8e-18 64.9 0.4 1.8 1 1 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 EFX03843.1 - 1.9e-13 49.7 0.8 0.0017 17.9 0.1 4.7 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX03843.1 - 1.6e-08 34.1 1.7 0.0015 18.2 0.3 3.9 3 1 1 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 EFX03843.1 - 0.0018 18.1 4.2 29 5.1 0.0 6.0 8 0 0 8 8 8 0 Leucine Rich repeat LRR_9 PF14580.1 EFX03843.1 - 0.015 14.8 0.1 0.89 9.0 0.0 2.8 1 1 2 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.28 EFX03843.1 - 0.026 14.5 6.0 50 4.5 0.3 6.1 4 3 3 7 7 7 0 Leucine Rich Repeat LRR_7 PF13504.1 EFX03843.1 - 0.047 13.8 5.9 48 4.8 0.1 5.9 6 0 0 6 6 6 0 Leucine rich repeat Sec7 PF01369.15 EFX03844.1 - 2.5e-58 196.8 0.0 8.9e-58 195.0 0.0 1.8 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.2 EFX03844.1 - 8.7e-18 64.3 0.1 6.4e-11 41.9 0.0 3.3 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Peptidase_C15 PF01470.12 EFX03845.1 - 6.7e-09 35.8 0.0 0.0017 18.2 0.0 3.4 4 0 0 4 4 4 3 Pyroglutamyl peptidase ADH_N PF08240.7 EFX03846.1 - 2.8e-27 94.6 0.1 5.4e-27 93.7 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX03846.1 - 2.6e-10 39.9 0.1 5.5e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 EFX03846.1 - 8.2e-07 28.5 0.7 2e-06 27.3 0.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated HI0933_like PF03486.9 EFX03846.1 - 0.0014 17.1 0.4 0.0083 14.6 0.1 1.9 2 0 0 2 2 2 1 HI0933-like protein Shikimate_DH PF01488.15 EFX03846.1 - 0.02 14.9 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 EFX03846.1 - 0.025 13.5 0.2 0.034 13.0 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX03846.1 - 0.06 12.1 0.5 0.081 11.7 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.1 EFX03846.1 - 0.073 13.1 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX03846.1 - 0.078 13.3 0.1 0.2 12.1 0.0 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EFX03846.1 - 0.15 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.13 EFX03846.1 - 0.2 11.3 0.2 0.3 10.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Kelch_3 PF13415.1 EFX03849.1 - 2.3e-28 97.6 18.6 6.7e-09 35.6 0.2 9.0 8 1 0 8 8 8 6 Galactose oxidase, central domain Kelch_4 PF13418.1 EFX03849.1 - 1.2e-22 79.4 23.7 1.1e-08 34.6 0.2 7.2 7 2 1 8 8 8 5 Galactose oxidase, central domain Kelch_1 PF01344.20 EFX03849.1 - 6.4e-22 76.8 0.6 2.2e-06 27.1 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 EFX03849.1 - 2.2e-20 71.8 6.7 6.2e-06 26.1 0.0 5.9 5 1 1 6 6 6 4 Kelch motif Kelch_5 PF13854.1 EFX03849.1 - 1.6e-18 66.2 8.0 0.00068 19.5 0.0 7.3 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.10 EFX03849.1 - 2.9e-14 52.1 8.2 1.5e-05 24.5 0.2 5.7 5 1 0 5 5 5 3 Kelch motif eIF-5_eIF-2B PF01873.12 EFX03850.1 - 3.4e-39 133.3 0.0 6.5e-39 132.4 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 EFX03850.1 - 3.1e-25 87.9 0.5 3.1e-25 87.9 0.3 2.4 3 1 1 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon RsbRD_N PF14361.1 EFX03850.1 - 0.41 11.1 3.3 1.3 9.4 0.8 2.4 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain SpoIIE PF07228.7 EFX03851.1 - 1.8e-10 40.8 0.2 7.5e-10 38.8 0.1 1.9 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 EFX03851.1 - 1.2e-09 37.9 0.5 0.0013 18.1 0.0 3.1 3 0 0 3 3 3 2 Protein phosphatase 2C PP2C_2 PF13672.1 EFX03851.1 - 1.8e-08 34.0 0.1 3.6e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C Acetate_kinase PF00871.12 EFX03853.1 - 4.2e-87 292.2 0.0 5.7e-87 291.7 0.0 1.1 1 0 0 1 1 1 1 Acetokinase family FEZ PF07763.8 EFX03853.1 - 0.24 11.0 0.0 0.42 10.2 0.0 1.3 1 0 0 1 1 1 0 FEZ-like protein Macoilin PF09726.4 EFX03853.1 - 1.2 7.3 5.8 1.6 6.9 4.0 1.1 1 0 0 1 1 1 0 Transmembrane protein MoaC PF01967.16 EFX03854.1 - 1.2e-48 164.1 0.8 2.3e-48 163.3 0.6 1.5 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.8 EFX03854.1 - 4.7e-32 110.3 0.0 1.2e-31 109.0 0.0 1.6 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.16 EFX03854.1 - 1.2e-20 74.2 0.0 3.4e-20 72.8 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 EFX03854.1 - 0.00023 21.1 0.0 0.0016 18.4 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EFX03854.1 - 0.0004 20.5 0.0 0.0015 18.6 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain UPRTase PF14681.1 EFX03856.1 - 5.1e-48 163.0 0.0 5.1e-45 153.2 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EFX03856.1 - 7.1e-11 41.9 0.0 9.4e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MFS_1 PF07690.11 EFX03857.1 - 2.6e-46 157.9 15.9 2.6e-46 157.9 11.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX03857.1 - 3.5e-10 39.0 1.8 3.5e-10 39.0 1.3 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter NACHT PF05729.7 EFX03859.1 - 5.1e-16 58.7 0.0 1.4e-15 57.3 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EFX03859.1 - 2e-09 37.7 0.0 1.4e-07 31.7 0.0 3.4 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.17 EFX03859.1 - 8.2e-08 31.4 0.0 2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 EFX03859.1 - 0.00018 21.5 3.4 0.03 14.3 1.4 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 EFX03859.1 - 0.0045 17.2 0.2 0.028 14.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX03859.1 - 0.0052 17.5 0.9 0.028 15.2 0.7 2.4 1 1 0 1 1 1 1 AAA domain Abhydrolase_6 PF12697.2 EFX03859.1 - 0.0061 16.4 0.0 0.042 13.7 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family AAA_14 PF13173.1 EFX03859.1 - 0.008 16.0 0.2 0.046 13.6 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 EFX03859.1 - 0.024 14.3 0.0 0.56 9.9 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain PduV-EutP PF10662.4 EFX03859.1 - 0.04 13.4 0.0 0.081 12.4 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.12 EFX03859.1 - 0.059 13.1 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 NTPase_1 PF03266.10 EFX03859.1 - 0.063 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 NTPase MobB PF03205.9 EFX03859.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 EFX03859.1 - 0.073 13.2 0.0 0.28 11.3 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF829 PF05705.9 EFX03859.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) AAA_30 PF13604.1 EFX03859.1 - 0.19 11.2 0.1 2.7 7.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Hist_deacetyl PF00850.14 EFX03860.1 - 1.4e-77 261.0 0.0 3.1e-77 259.9 0.0 1.6 1 0 0 1 1 1 1 Histone deacetylase domain SH3_9 PF14604.1 EFX03861.1 - 6.1e-07 28.9 0.2 1.3e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFX03861.1 - 0.00041 19.6 0.5 0.0008 18.7 0.4 1.5 1 0 0 1 1 1 1 SH3 domain Yip1 PF04893.12 EFX03861.1 - 0.014 14.8 0.9 0.024 14.1 0.6 1.3 1 0 0 1 1 1 0 Yip1 domain TMEM154 PF15102.1 EFX03861.1 - 0.083 12.5 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Ank_2 PF12796.2 EFX03862.1 - 2.1e-12 47.2 0.0 2.4e-09 37.3 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) NACHT PF05729.7 EFX03862.1 - 9.5e-12 44.8 0.1 2.4e-11 43.5 0.1 1.7 1 0 0 1 1 1 1 NACHT domain Ank PF00023.25 EFX03862.1 - 6.6e-11 41.4 0.1 2.1e-05 24.0 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat AAA_16 PF13191.1 EFX03862.1 - 2.5e-10 40.6 0.0 1e-09 38.6 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Ank_3 PF13606.1 EFX03862.1 - 7.6e-07 28.7 0.9 0.24 11.7 0.1 4.9 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.1 EFX03862.1 - 1.3e-05 25.2 0.1 0.00073 19.7 0.1 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) AAA_22 PF13401.1 EFX03862.1 - 0.00011 22.3 0.1 0.00077 19.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX03862.1 - 0.00036 21.3 0.0 0.0013 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain Ank_4 PF13637.1 EFX03862.1 - 0.0013 19.1 0.1 0.06 13.8 0.0 3.5 3 1 1 4 4 4 1 Ankyrin repeats (many copies) AAA_18 PF13238.1 EFX03862.1 - 0.0014 18.9 0.0 0.0058 16.9 0.0 2.1 2 1 0 2 2 1 1 AAA domain Arch_ATPase PF01637.13 EFX03862.1 - 0.0033 17.1 0.1 0.031 13.9 0.0 2.3 2 0 0 2 2 2 1 Archaeal ATPase TIP49 PF06068.8 EFX03862.1 - 0.0069 15.1 0.9 0.049 12.3 0.0 2.0 2 0 0 2 2 2 1 TIP49 C-terminus AAA_25 PF13481.1 EFX03862.1 - 0.0081 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 EFX03862.1 - 0.014 15.3 0.0 0.094 12.6 0.0 2.4 1 1 1 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.1 EFX03862.1 - 0.018 14.9 0.5 0.051 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 EFX03862.1 - 0.021 14.5 0.0 0.08 12.6 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain KTI12 PF08433.5 EFX03862.1 - 0.023 13.8 0.0 0.058 12.5 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 EFX03862.1 - 0.037 13.1 0.0 0.071 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 EFX03862.1 - 0.039 14.1 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 EFX03862.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.15 EFX03862.1 - 0.11 12.1 0.1 0.35 10.5 0.0 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.24 EFX03862.1 - 0.14 12.4 4.2 0.16 12.1 0.4 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APH PF01636.18 EFX03863.1 - 2.2e-10 40.6 0.0 2.2e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFX03863.1 - 0.031 13.8 0.0 0.034 13.7 0.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.6 EFX03863.1 - 0.031 12.9 0.0 0.049 12.2 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) DUF4164 PF13747.1 EFX03863.1 - 0.08 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) RIO1 PF01163.17 EFX03863.1 - 0.15 11.4 0.2 0.21 10.9 0.1 1.4 1 1 0 1 1 1 0 RIO1 family Nop14 PF04147.7 EFX03863.1 - 7.7 4.3 8.1 9.7 3.9 5.6 1.0 1 0 0 1 1 1 0 Nop14-like family SET PF00856.23 EFX03864.1 - 0.041 14.1 0.0 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 SET domain Oxidored_FMN PF00724.15 EFX03865.1 - 9.9e-71 238.4 0.0 1.2e-70 238.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family JAB PF01398.16 EFX03866.1 - 1.7e-34 117.9 0.0 3.2e-34 117.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 EFX03866.1 - 1.5e-26 92.7 1.5 1.5e-26 92.7 1.0 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 EFX03866.1 - 1.2e-08 34.4 0.0 2.2e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Chordopox_A13L PF05961.6 EFX03866.1 - 0.1 12.5 0.1 0.8 9.6 0.1 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Pyr_redox_2 PF07992.9 EFX03867.1 - 1.9e-24 86.6 0.0 4.6e-24 85.4 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX03867.1 - 2.8e-13 50.0 0.0 1.9e-11 44.2 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX03867.1 - 0.0025 17.9 0.3 0.64 10.0 0.1 3.3 3 1 2 5 5 5 2 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.20 EFX03868.1 - 8.8e-32 110.2 0.0 1.7e-31 109.3 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03868.1 - 4.3e-16 58.7 0.0 7.7e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX03868.1 - 0.00026 20.0 0.0 0.00054 19.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 EFX03868.1 - 0.0078 15.9 0.1 0.039 13.6 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 EFX03868.1 - 0.081 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family F1F0-ATPsyn_F PF10791.4 EFX03869.1 - 1.2e-40 137.5 1.0 1.4e-40 137.4 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 EFX03869.1 - 0.034 14.1 0.1 0.044 13.8 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f PgaD PF13994.1 EFX03870.1 - 0.056 12.9 0.2 0.095 12.1 0.2 1.3 1 0 0 1 1 1 0 PgaD-like protein Herpes_gE PF02480.11 EFX03871.1 - 0.0084 14.4 0.0 0.012 13.9 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Mid2 PF04478.7 EFX03871.1 - 0.08 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor K_channel_TID PF07941.6 EFX03872.1 - 0.02 15.1 12.1 0.02 15.1 8.4 3.7 2 1 1 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain MFS_1 PF07690.11 EFX03873.1 - 6.9e-28 97.3 61.8 5.2e-24 84.6 26.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2422 PF10337.4 EFX03873.1 - 0.23 10.2 1.1 0.52 9.0 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Pkinase PF00069.20 EFX03875.1 - 5.7e-64 215.7 0.0 7.9e-64 215.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03875.1 - 5.8e-26 91.1 0.0 8.2e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFX03875.1 - 0.062 13.0 0.2 0.28 10.8 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF221 PF02714.10 EFX03876.1 - 5.5e-103 344.2 11.7 1e-102 343.3 8.1 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFX03876.1 - 7.6e-41 139.2 3.1 7.6e-41 139.2 2.2 2.2 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EFX03876.1 - 1e-20 73.3 0.1 1e-20 73.3 0.1 1.9 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 EFX03876.1 - 1.7e-10 41.2 1.4 5.5e-06 26.8 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4463) Oxysterol_BP PF01237.13 EFX03878.1 - 8.2e-53 179.1 0.0 5.2e-42 143.6 0.0 2.2 2 0 0 2 2 2 2 Oxysterol-binding protein Fungal_trans PF04082.13 EFX03879.1 - 8.1e-25 87.1 0.0 1.2e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03879.1 - 1.1e-06 28.3 8.2 2.6e-06 27.2 5.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2076 PF09849.4 EFX03879.1 - 0.0082 16.2 0.2 0.014 15.4 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF869 PF05911.6 EFX03879.1 - 0.26 9.4 0.0 0.38 8.9 0.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Pox_A_type_inc PF04508.7 EFX03879.1 - 6.2 6.8 5.9 1.7 8.6 0.8 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Glyco_hydro_45 PF02015.11 EFX03880.1 - 1.1e-16 61.5 17.9 1.1e-16 61.5 12.4 2.4 2 2 0 2 2 2 1 Glycosyl hydrolase family 45 DPBB_1 PF03330.13 EFX03880.1 - 3.3e-07 30.2 0.6 3.3e-07 30.2 0.4 2.5 2 0 0 2 2 2 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel SOG2 PF10428.4 EFX03880.1 - 0.88 8.1 11.9 1.1 7.8 8.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Redoxin PF08534.5 EFX03881.1 - 5.1e-27 94.2 0.0 6.2e-27 93.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EFX03881.1 - 8.9e-07 28.6 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family AhpC-TSA_2 PF13911.1 EFX03882.1 - 1.2e-17 63.9 0.0 1.7e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 EFX03882.1 - 0.00012 21.7 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFX03882.1 - 0.0027 17.2 0.0 0.0037 16.8 0.0 1.2 1 0 0 1 1 1 1 Redoxin NUP PF06516.6 EFX03883.1 - 1.5e-119 398.4 0.0 1.8e-119 398.2 0.0 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) bZIP_1 PF00170.16 EFX03884.1 - 2e-09 37.2 7.5 2.8e-09 36.7 5.2 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX03884.1 - 1.2e-06 28.2 8.0 1.9e-06 27.6 5.5 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EFX03884.1 - 0.00026 21.2 6.6 0.0004 20.6 4.6 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Phage_int_SAM_2 PF12834.2 EFX03884.1 - 0.011 16.0 1.0 0.018 15.4 0.7 1.2 1 0 0 1 1 1 0 Phage integrase, N-terminal DUF724 PF05266.9 EFX03884.1 - 0.031 13.8 0.1 0.037 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.1 EFX03884.1 - 0.058 12.3 1.0 0.084 11.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Lge1 PF11488.3 EFX03884.1 - 2.2 8.5 4.7 0.52 10.5 0.4 2.1 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 F-box PF00646.28 EFX03886.1 - 0.00048 19.7 0.1 0.0013 18.3 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFX03886.1 - 0.002 17.7 0.6 0.01 15.5 0.0 2.4 3 0 0 3 3 3 1 F-box-like IPPT PF01715.12 EFX03887.1 - 4.7e-44 150.3 1.7 2.2e-32 112.0 0.0 3.2 2 1 0 2 2 2 2 IPP transferase zf-C2H2_jaz PF12171.3 EFX03887.1 - 0.00014 21.9 0.2 0.00034 20.6 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX03887.1 - 0.00014 21.8 0.1 0.00028 20.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type IPT PF01745.11 EFX03887.1 - 0.00032 19.9 0.0 0.00082 18.6 0.0 1.6 1 0 0 1 1 1 1 Isopentenyl transferase AAA_18 PF13238.1 EFX03887.1 - 0.0031 17.8 0.0 0.16 12.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX03887.1 - 0.0033 18.2 0.1 0.013 16.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFX03887.1 - 0.011 15.6 0.4 0.44 10.4 0.0 3.3 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.1 EFX03887.1 - 0.092 12.5 0.0 0.3 10.8 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain Pkinase PF00069.20 EFX03888.1 - 1.2e-09 37.6 0.0 1.2e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX03888.1 - 0.0005 19.2 0.0 0.0006 18.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FimP PF09766.4 EFX03889.1 - 4.2e-27 95.1 14.3 5.3e-27 94.8 9.9 1.1 1 0 0 1 1 1 1 Fms-interacting protein DUF972 PF06156.8 EFX03889.1 - 0.08 13.3 9.0 2.5 8.4 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF87 PF01935.12 EFX03889.1 - 0.2 11.4 3.4 0.26 11.0 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 DUF4200 PF13863.1 EFX03889.1 - 0.63 9.9 21.0 3.8 7.4 4.2 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Mnd1 PF03962.10 EFX03889.1 - 0.74 9.4 12.9 2.5 7.7 3.2 2.2 2 0 0 2 2 2 0 Mnd1 family DUF1040 PF06288.8 EFX03889.1 - 1.2 9.4 6.9 0.21 11.8 1.9 1.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1040) K-box PF01486.12 EFX03889.1 - 1.4 8.7 19.9 0.17 11.6 6.9 3.4 1 1 2 3 3 3 0 K-box region HNOBA PF07701.9 EFX03889.1 - 3 6.9 6.9 6.2 5.9 4.8 1.6 1 1 0 1 1 1 0 Heme NO binding associated FlxA PF14282.1 EFX03889.1 - 7.1 6.6 10.1 0.59 10.1 1.4 2.2 2 0 0 2 2 2 0 FlxA-like protein His_Phos_1 PF00300.17 EFX03890.1 - 1.5e-12 47.9 0.0 2.3e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Alba PF01918.16 EFX03891.1 - 0.002 17.7 0.0 0.0054 16.3 0.0 1.8 1 0 0 1 1 1 1 Alba DUF605 PF04652.11 EFX03891.1 - 0.63 9.3 21.2 0.23 10.8 12.7 1.6 2 0 0 2 2 2 0 Vta1 like FSH1 PF03959.8 EFX03892.1 - 1.9e-33 115.6 0.0 1.1e-32 113.1 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 EFX03892.1 - 0.04 13.3 0.2 13 5.1 0.0 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase CK_II_beta PF01214.13 EFX03893.1 - 1.9e-74 249.1 0.0 4e-74 248.0 0.0 1.5 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Nucleoplasmin PF03066.10 EFX03893.1 - 0.019 14.4 9.4 0.17 11.3 5.4 2.2 2 0 0 2 2 2 0 Nucleoplasmin Spt5_N PF11942.3 EFX03893.1 - 0.028 15.0 7.2 0.028 15.0 5.0 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RRN3 PF05327.6 EFX03893.1 - 3.4 5.6 6.4 0.18 9.8 0.5 1.6 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 PBP1_TM PF14812.1 EFX03893.1 - 3.6 7.9 14.3 1 9.7 3.0 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.6 EFX03893.1 - 4.7 4.9 5.5 2.5 5.8 0.9 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Tom37_C PF11801.3 EFX03893.1 - 8.3 6.2 7.0 15 5.4 0.2 2.2 2 0 0 2 2 2 0 Tom37 C-terminal domain ABC1 PF03109.11 EFX03895.1 - 3.7e-31 107.5 0.0 6e-31 106.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family HA2 PF04408.18 EFX03896.1 - 4.5e-19 68.3 0.0 9.2e-19 67.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EFX03896.1 - 4.8e-14 52.1 0.1 9.9e-14 51.1 0.1 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EFX03896.1 - 1.5e-12 47.2 0.1 3.8e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFX03896.1 - 1.3e-06 28.0 0.1 1.5e-05 24.5 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFX03896.1 - 1e-05 25.6 0.0 2.6e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 EFX03896.1 - 0.00019 20.4 0.0 0.00036 19.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 EFX03896.1 - 0.035 13.6 0.0 0.12 11.9 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2666 PF10869.3 EFX03896.1 - 0.11 12.5 0.4 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) Peptidase_S8 PF00082.17 EFX03897.1 - 2.4e-13 49.9 0.2 4.1e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 Subtilase family LigB PF02900.13 EFX03898.1 - 4.9e-29 101.1 0.1 5.9e-29 100.8 0.1 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Creatininase PF02633.9 EFX03898.1 - 0.051 12.6 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Creatinine amidohydrolase GST_N_2 PF13409.1 EFX03899.1 - 1.5e-16 60.1 0.0 3.5e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EFX03899.1 - 1.2e-12 47.4 0.1 3e-12 46.2 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFX03899.1 - 0.00036 20.9 0.0 0.00069 20.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFX03899.1 - 0.00097 19.3 0.0 0.037 14.2 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EFX03899.1 - 0.0013 18.6 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Vps23_core PF09454.5 EFX03900.1 - 1.6e-20 72.4 0.0 2.9e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Vps23 core domain Mito_fiss_reg PF05308.6 EFX03900.1 - 0.028 13.7 1.4 0.037 13.4 1.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator V-SNARE_C PF12352.3 EFX03900.1 - 0.16 12.0 1.8 1.7 8.7 0.3 2.2 1 1 1 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus HAD PF12710.2 EFX03901.1 - 1.2e-08 35.3 0.0 2.8e-08 34.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 EFX03901.1 - 0.0019 17.4 0.1 0.86 8.7 0.0 2.2 2 0 0 2 2 2 2 Putative Phosphatase Hydrolase PF00702.21 EFX03901.1 - 0.097 13.0 0.2 13 6.1 0.0 2.4 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Arb1 PF09692.5 EFX03901.1 - 0.12 11.2 0.2 0.18 10.6 0.1 1.2 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Pro-kuma_activ PF09286.6 EFX03902.1 - 2.6e-38 131.2 0.0 1e-37 129.3 0.0 2.0 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFX03902.1 - 6.4e-07 28.8 0.1 1.1e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Subtilase family DUF2014 PF09427.5 EFX03902.1 - 0.2 10.7 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) DUF2454 PF10521.4 EFX03905.1 - 6.4e-56 189.4 0.0 8.7e-56 188.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) HET PF06985.6 EFX03906.1 - 2e-11 44.2 0.0 6e-11 42.6 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Amidohydro_2 PF04909.9 EFX03907.1 - 5.1e-12 45.9 2.4 1.4e-11 44.4 1.6 1.9 1 1 0 1 1 1 1 Amidohydrolase V-ATPase_G PF03179.10 EFX03908.1 - 1.8e-28 98.9 15.4 2.6e-28 98.3 10.7 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.13 EFX03908.1 - 0.02 14.6 11.6 0.02 14.6 8.0 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF4192 PF13830.1 EFX03908.1 - 0.042 13.5 4.4 0.061 12.9 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Hex_IIIa PF02455.11 EFX03908.1 - 0.4 9.3 4.2 0.47 9.0 2.9 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF2229 PF09989.4 EFX03908.1 - 1 8.7 3.0 1.6 8.1 2.0 1.3 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Nop25 PF09805.4 EFX03908.1 - 2.6 8.0 14.5 4.2 7.4 10.0 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Borrelia_P83 PF05262.6 EFX03908.1 - 5.2 5.2 12.9 7.4 4.7 9.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SH2_2 PF14633.1 EFX03909.1 - 7.9e-85 283.4 0.2 1.7e-84 282.3 0.1 1.6 1 0 0 1 1 1 1 SH2 domain DLD PF14878.1 EFX03909.1 - 1.8e-34 118.2 4.6 1.8e-34 118.2 3.2 3.3 3 0 0 3 3 3 1 Death-like domain of SPT6 HHH_7 PF14635.1 EFX03909.1 - 2.5e-28 98.2 0.0 5.8e-28 97.0 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.1 EFX03909.1 - 1.7e-27 95.8 0.0 5.8e-27 94.1 0.0 2.0 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.1 EFX03909.1 - 4.1e-23 81.3 29.4 4.1e-23 81.3 20.3 5.9 7 0 0 7 7 7 1 Acidic N-terminal SPT6 HTH_44 PF14641.1 EFX03909.1 - 1.4e-19 70.2 0.9 1.4e-18 67.0 0.6 2.6 1 1 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 S1 PF00575.18 EFX03909.1 - 1.5e-07 31.4 0.5 3.9e-07 30.0 0.4 1.7 1 0 0 1 1 1 1 S1 RNA binding domain SH2 PF00017.19 EFX03909.1 - 0.00023 20.8 0.0 0.00066 19.4 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.2 EFX03909.1 - 0.062 13.2 0.0 0.22 11.4 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF2716 PF10898.3 EFX03909.1 - 0.075 13.0 0.0 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2716) Glyco_hydro_43 PF04616.9 EFX03910.1 - 2.4e-21 76.0 8.5 1.4e-08 34.1 0.1 3.7 3 1 0 3 3 3 3 Glycosyl hydrolases family 43 4HBT PF03061.17 EFX03911.1 - 2.7e-09 37.0 0.0 4.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 EFX03911.1 - 1.7e-05 24.7 0.2 2.5e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily p450 PF00067.17 EFX03912.1 - 1.7e-56 191.7 0.0 2.9e-56 190.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 fn3_3 PF14686.1 EFX03913.1 - 0.028 14.5 0.0 0.069 13.2 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 EFX03913.1 - 0.12 12.4 0.1 0.36 10.9 0.0 1.7 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain Totivirus_coat PF05518.6 EFX03913.1 - 3 5.5 14.7 4.7 4.9 10.2 1.2 1 0 0 1 1 1 0 Totivirus coat protein ABC_tran PF00005.22 EFX03914.1 - 0.052 13.8 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter OPT PF03169.10 EFX03915.1 - 2.1e-135 452.6 41.2 2.5e-135 452.3 28.5 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein adh_short PF00106.20 EFX03916.1 - 1.1e-12 48.2 0.3 8.9e-12 45.2 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFX03916.1 - 5.6e-06 26.1 0.3 1e-05 25.3 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX03916.1 - 7.1e-05 22.3 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ThiF PF00899.16 EFX03916.1 - 0.062 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 ThiF family Ank_2 PF12796.2 EFX03918.1 - 4.4e-05 23.7 0.1 0.00025 21.3 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Methyltransf_26 PF13659.1 EFX03918.1 - 0.062 13.3 0.3 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 EFX03919.1 - 2.3e-16 59.8 0.4 3.6e-16 59.2 0.3 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX03919.1 - 0.0025 17.2 0.2 0.022 14.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase small domain MCM PF00493.18 EFX03920.1 - 4.5e-81 272.2 2.2 1.4e-43 148.9 0.1 2.3 1 1 1 2 2 2 2 MCM2/3/5 family MCM_N PF14551.1 EFX03920.1 - 1.7e-16 60.7 0.1 8.3e-16 58.5 0.0 2.1 2 0 0 2 2 2 1 MCM N-terminal domain BSP_II PF05432.6 EFX03920.1 - 7.8 5.6 26.2 25 4.0 17.5 2.1 1 1 1 2 2 2 0 Bone sialoprotein II (BSP-II) NPP1 PF05630.6 EFX03921.1 - 6.6e-08 32.5 4.8 1.3e-06 28.2 3.4 2.7 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) DUF2370 PF10176.4 EFX03922.1 - 7e-84 280.8 0.4 1.2e-83 280.0 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2370) DUF202 PF02656.10 EFX03922.1 - 0.05 13.8 3.8 1.2 9.3 2.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF202) TMEM51 PF15345.1 EFX03922.1 - 0.089 12.4 2.8 1.1 8.9 0.0 2.9 2 1 0 3 3 3 0 Transmembrane protein 51 DUF2561 PF10812.3 EFX03922.1 - 0.14 11.6 0.1 0.14 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) Med3 PF11593.3 EFX03922.1 - 5 6.2 7.8 8.2 5.5 5.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Aminotran_1_2 PF00155.16 EFX03923.1 - 2.9e-35 121.9 0.0 3.6e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFX03923.1 - 0.00072 17.9 0.0 0.0013 17.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF3847 PF12958.2 EFX03923.1 - 0.23 11.2 2.9 5.1 6.9 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3847) TauD PF02668.11 EFX03924.1 - 6.4e-05 22.7 0.0 7.4e-05 22.5 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 7tm_2 PF00002.19 EFX03925.1 - 1.8e-05 23.9 10.4 3.2e-05 23.1 7.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 EFX03925.1 - 0.0015 17.4 5.1 0.003 16.5 3.5 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Kelch_5 PF13854.1 EFX03925.1 - 0.6 10.1 2.7 3.5 7.6 0.0 2.8 3 0 0 3 3 3 0 Kelch motif DAO PF01266.19 EFX03926.1 - 3e-44 151.3 1.1 4.6e-44 150.7 0.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFX03926.1 - 4.6e-09 36.2 0.4 0.00092 19.0 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EFX03926.1 - 0.0008 19.3 0.1 0.0036 17.3 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFX03926.1 - 0.0017 18.2 0.0 0.81 9.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX03926.1 - 0.0029 16.5 0.0 0.0045 15.9 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.9 EFX03926.1 - 0.0073 14.9 0.0 0.15 10.6 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Amino_oxidase PF01593.19 EFX03926.1 - 0.036 13.1 0.0 0.066 12.2 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.14 EFX03926.1 - 0.043 12.8 0.1 4.3 6.2 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Saccharop_dh PF03435.13 EFX03926.1 - 0.067 12.1 0.1 0.11 11.4 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Pyr_redox_3 PF13738.1 EFX03926.1 - 0.072 13.1 0.0 2.5 8.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Suc_Fer-like PF06999.7 EFX03927.1 - 1.5e-47 162.5 0.0 2.3e-47 161.9 0.0 1.3 1 1 0 1 1 1 1 Sucrase/ferredoxin-like DUF1751 PF08551.5 EFX03928.1 - 8.8e-08 32.3 0.5 1.6e-07 31.5 0.4 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 EFX03928.1 - 0.00015 21.8 1.2 0.00028 20.9 0.8 1.6 1 0 0 1 1 1 1 Rhomboid family DER1 PF04511.10 EFX03928.1 - 0.019 14.5 4.5 0.025 14.1 3.1 1.4 1 1 0 1 1 1 0 Der1-like family Abhydrolase_6 PF12697.2 EFX03929.1 - 2.8e-05 24.1 3.3 2.8e-05 24.1 2.3 3.6 2 2 1 3 3 3 1 Alpha/beta hydrolase family LCAT PF02450.10 EFX03929.1 - 0.0027 16.7 0.0 0.0045 16.0 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.9 EFX03929.1 - 0.25 10.6 0.0 0.4 9.9 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) RhoGAP PF00620.22 EFX03930.1 - 1.8e-16 60.1 0.3 6e-16 58.4 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.16 EFX03930.1 - 4e-14 52.1 0.0 1e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.18 EFX03930.1 - 1.3e-13 50.8 0.1 5.5e-13 48.9 0.0 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF3993 PF13158.1 EFX03930.1 - 0.18 11.5 0.8 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) Med4 PF10018.4 EFX03930.1 - 0.39 10.0 5.2 0.48 9.7 0.0 2.6 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Rota_VP2 PF05087.7 EFX03930.1 - 3.1 5.5 5.8 4.5 5.0 4.0 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein Ribosomal_60s PF00428.14 EFX03930.1 - 3.7 7.9 20.2 0.12 12.8 7.0 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Acetyltransf_3 PF13302.1 EFX03931.1 - 5.9e-20 71.8 0.0 8.2e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFX03931.1 - 5.8e-09 35.9 2.8 4.8e-05 23.2 1.8 2.9 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX03931.1 - 7.2e-06 25.6 0.1 0.035 13.8 0.0 2.3 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_1 PF00583.19 EFX03931.1 - 0.00046 20.1 0.9 0.011 15.7 0.7 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EFX03931.1 - 0.054 13.4 0.0 0.45 10.4 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain WLM PF08325.5 EFX03932.1 - 1.3e-53 181.6 0.1 4.2e-53 179.9 0.0 1.8 1 1 0 1 1 1 1 WLM domain DZR PF12773.2 EFX03932.1 - 0.0062 16.3 7.3 0.071 12.9 5.1 2.2 1 1 1 2 2 2 2 Double zinc ribbon DUF45 PF01863.12 EFX03932.1 - 0.0086 15.8 0.6 0.0086 15.8 0.4 1.6 2 0 0 2 2 2 1 Protein of unknown function DUF45 DUF955 PF06114.8 EFX03932.1 - 0.18 11.5 0.4 0.38 10.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF955) PHD PF00628.24 EFX03932.1 - 7 6.4 14.5 7.7 6.2 0.7 3.3 2 1 1 3 3 3 0 PHD-finger ABC2_membrane PF01061.19 EFX03933.1 - 2.2e-84 281.8 49.0 1.4e-48 164.8 12.6 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 EFX03933.1 - 7.7e-41 139.5 0.0 5.7e-20 72.0 0.0 3.1 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.7 EFX03933.1 - 1.8e-20 72.5 2.4 1.8e-18 66.1 0.0 3.0 3 0 0 3 3 2 1 CDR ABC transporter ABC2_membrane_3 PF12698.2 EFX03933.1 - 1.7e-09 37.2 28.2 1.1e-06 27.9 10.4 2.8 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 EFX03933.1 - 3.7e-07 30.4 0.0 0.074 13.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 EFX03933.1 - 7.6e-06 26.0 0.1 0.071 13.0 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 EFX03933.1 - 3.8e-05 23.1 0.0 0.12 11.7 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.1 EFX03933.1 - 0.00013 22.2 0.0 0.17 12.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFX03933.1 - 0.00015 21.8 0.0 0.039 14.0 0.0 3.0 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 EFX03933.1 - 0.00047 19.3 0.0 0.0056 15.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EFX03933.1 - 0.00096 19.9 0.0 0.035 14.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 EFX03933.1 - 0.0011 18.6 0.0 0.51 9.9 0.0 2.7 2 0 0 2 2 2 1 Archaeal ATPase AAA_28 PF13521.1 EFX03933.1 - 0.0017 18.3 0.1 0.032 14.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 EFX03933.1 - 0.0017 18.0 0.0 0.16 11.6 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 EFX03933.1 - 0.004 17.0 0.0 0.067 13.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 EFX03933.1 - 0.0041 16.6 0.1 0.057 12.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_19 PF13245.1 EFX03933.1 - 0.011 15.4 0.0 2.1 8.1 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain cobW PF02492.14 EFX03933.1 - 0.016 14.6 0.1 0.67 9.3 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 EFX03933.1 - 0.018 15.2 0.1 4.8 7.3 0.0 3.1 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 EFX03933.1 - 0.032 14.1 0.0 0.21 11.5 0.0 2.3 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF1738 PF08401.6 EFX03933.1 - 0.036 13.7 0.0 0.58 9.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1738) Ribosomal_S28e PF01200.13 EFX03933.1 - 0.046 13.4 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S28e PduV-EutP PF10662.4 EFX03933.1 - 0.054 12.9 0.0 2.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 EFX03933.1 - 0.082 11.6 0.2 0.47 9.1 0.0 2.3 3 0 0 3 3 3 0 ArgK protein NACHT PF05729.7 EFX03933.1 - 0.086 12.4 0.1 2.3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.18 EFX03933.1 - 0.17 11.8 0.1 19 5.2 0.0 3.0 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_30 PF13604.1 EFX03933.1 - 0.24 10.9 0.0 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain CPSF_A PF03178.10 EFX03934.1 - 3.2e-82 276.1 0.0 6.8e-82 275.1 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.4 EFX03934.1 - 0.029 12.5 0.0 0.066 11.3 0.0 1.6 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Mucin PF01456.12 EFX03934.1 - 0.091 12.5 1.9 1.4 8.7 1.1 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein HSCB_C PF07743.8 EFX03936.1 - 1.1e-13 51.3 2.1 2e-13 50.5 0.7 2.1 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 EFX03936.1 - 1.1e-05 25.0 0.0 2.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain LRR_4 PF12799.2 EFX03936.1 - 1.1 8.9 4.6 15 5.3 0.6 2.7 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) APC_crr PF05923.7 EFX03939.1 - 0.47 10.1 3.8 0.44 10.2 0.3 2.2 2 0 0 2 2 2 0 APC cysteine-rich region Bromo_TP PF07524.8 EFX03940.1 - 1.6e-08 34.1 0.0 2.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Myb_DNA-bind_4 PF13837.1 EFX03941.1 - 0.23 11.6 2.6 0.98 9.6 0.7 2.5 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain APC_CDC26 PF10471.4 EFX03941.1 - 3 8.6 9.2 20 5.9 0.0 3.6 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 PUF PF00806.14 EFX03942.1 - 8.1e-61 198.2 9.2 1e-07 31.0 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat TylF PF05711.6 EFX03942.1 - 0.0014 17.7 0.1 0.0028 16.7 0.0 1.4 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) DUF2054 PF10218.4 EFX03942.1 - 0.0035 17.1 0.8 0.042 13.6 0.0 2.5 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2054) DUF342 PF03961.8 EFX03942.1 - 0.31 9.4 1.4 0.5 8.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Tnp_P_element PF12017.3 EFX03942.1 - 2 7.5 6.1 0.58 9.3 1.1 2.3 3 0 0 3 3 3 0 Transposase protein MFS_1 PF07690.11 EFX03943.1 - 1.2e-29 103.1 19.6 1.2e-29 103.1 13.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX03943.1 - 4.6e-12 45.2 6.8 4.6e-12 45.2 4.7 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.15 EFX03943.1 - 0.0012 17.0 1.1 0.0012 17.0 0.8 2.4 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family PUCC PF03209.10 EFX03943.1 - 0.0087 14.8 5.8 0.027 13.1 2.0 2.2 2 0 0 2 2 2 1 PUCC protein BT1 PF03092.11 EFX03943.1 - 0.053 12.2 4.1 0.18 10.5 0.1 2.5 2 1 1 3 3 3 0 BT1 family Elong_Iki1 PF10483.4 EFX03944.1 - 3.1e-59 200.6 0.0 3.7e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Elongator subunit Iki1 Methyltransf_23 PF13489.1 EFX03945.1 - 1.7e-20 73.3 0.0 2.5e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX03945.1 - 5.1e-11 43.1 0.0 4.8e-10 40.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX03945.1 - 6.9e-10 38.7 0.0 2.9e-09 36.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX03945.1 - 1.6e-09 38.0 0.0 8.7e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX03945.1 - 2.3e-08 34.4 0.0 8.8e-08 32.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX03945.1 - 0.00097 19.1 0.3 0.005 16.8 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX03945.1 - 0.0027 18.0 0.0 0.0089 16.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFX03945.1 - 0.0046 16.1 0.0 0.0076 15.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 EFX03945.1 - 0.01 15.3 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.14 EFX03945.1 - 0.029 13.8 0.0 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 EFX03945.1 - 0.2 10.7 0.0 0.37 9.8 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Cpn10 PF00166.16 EFX03946.1 - 6.5e-27 93.3 0.0 7.3e-27 93.1 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit SIM_C PF06621.7 EFX03947.1 - 0.021 14.3 0.2 0.023 14.2 0.1 1.1 1 0 0 1 1 1 0 Single-minded protein C-terminus Fer4 PF00037.22 EFX03948.1 - 1.8e-13 49.4 16.5 5.9e-08 31.9 2.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 EFX03948.1 - 6.1e-12 45.7 10.3 1e-11 45.0 7.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.1 EFX03948.1 - 9.7e-10 39.0 7.1 0.00025 21.7 0.3 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.1 EFX03948.1 - 1.6e-09 37.8 9.3 2.9e-09 37.0 6.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EFX03948.1 - 2.7e-09 36.6 21.9 6.7e-08 32.2 8.3 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 EFX03948.1 - 1.5e-08 34.3 32.0 1.4e-05 24.8 8.6 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.1 EFX03948.1 - 1.5e-07 31.3 20.3 2.5e-05 24.2 8.0 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.2 EFX03948.1 - 2.8e-07 30.0 17.1 0.0013 18.4 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.2 EFX03948.1 - 2.9e-07 30.0 15.4 0.00058 19.6 1.4 2.5 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_4 PF12800.2 EFX03948.1 - 6.4e-06 26.0 12.7 0.00064 19.8 2.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 EFX03948.1 - 1.4e-05 25.2 10.2 0.0016 18.7 7.9 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.1 EFX03948.1 - 7.9e-05 23.0 9.8 0.018 15.4 0.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 EFX03948.1 - 0.011 16.1 15.2 0.33 11.3 3.2 2.7 2 1 1 3 3 3 0 4Fe-4S single cluster domain Fer4_15 PF13459.1 EFX03948.1 - 0.016 15.7 13.0 0.25 11.9 1.2 2.9 2 1 0 2 2 2 0 4Fe-4S single cluster domain Fer4_3 PF12798.2 EFX03948.1 - 0.086 13.4 16.9 0.17 12.4 2.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 EFX03948.1 - 0.15 12.1 4.8 0.41 10.7 0.1 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain polyprenyl_synt PF00348.12 EFX03949.1 - 2.8e-57 193.5 0.0 3.2e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase zf-RING_2 PF13639.1 EFX03950.1 - 1.4e-07 31.2 2.9 2.6e-07 30.3 2.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFX03950.1 - 3.3e-07 30.2 4.7 1.3e-06 28.2 3.3 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX03950.1 - 3.3e-07 29.8 2.5 6.9e-07 28.8 1.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX03950.1 - 1e-06 28.3 2.4 1.9e-06 27.4 1.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFX03950.1 - 4.9e-06 26.1 5.8 2.8e-05 23.6 4.1 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFX03950.1 - 1.9e-05 24.4 2.3 1.9e-05 24.4 1.6 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFX03950.1 - 0.0039 16.8 0.5 0.0039 16.8 0.3 2.0 2 0 0 2 2 2 1 RING-type zinc-finger TerY-C PF15616.1 EFX03950.1 - 0.05 13.5 0.7 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 TerY-C metal binding domain NDUFA12 PF05071.11 EFX03951.1 - 8.1e-26 90.5 0.8 1.1e-25 90.1 0.5 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 SAD_SRA PF02182.12 EFX03952.1 - 1.4e-31 108.9 0.0 2e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 SAD/SRA domain Beta-lactamase PF00144.19 EFX03953.1 - 2e-53 181.5 0.0 2.5e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.3 EFX03953.1 - 1.5e-05 24.7 0.0 2.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Aa_trans PF01490.13 EFX03954.1 - 6.6e-59 199.4 34.9 7.6e-59 199.2 24.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ATG27 PF09451.5 EFX03954.1 - 0.54 9.4 1.6 1.1 8.3 1.1 1.4 1 0 0 1 1 1 0 Autophagy-related protein 27 PP2C PF00481.16 EFX03955.1 - 4e-82 275.4 0.1 7e-82 274.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EFX03955.1 - 0.0035 16.7 0.0 0.015 14.7 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C SHMT PF00464.14 EFX03956.1 - 1.4e-190 632.8 0.0 1.7e-190 632.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Glyco_hydro_47 PF01532.15 EFX03957.1 - 8.7e-129 430.0 0.0 1.1e-128 429.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 EcKinase PF02958.15 EFX03958.1 - 1.2e-22 80.4 0.0 5.1e-13 48.8 0.0 2.1 2 0 0 2 2 2 2 Ecdysteroid kinase APH PF01636.18 EFX03958.1 - 9.7e-08 32.0 0.5 1.5e-07 31.3 0.4 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFX03958.1 - 2.1e-07 29.9 0.0 6e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) DUF1712 PF08217.6 EFX03959.1 - 5.1e-11 41.5 0.0 1.2e-10 40.3 0.0 1.6 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1712) WD40 PF00400.27 EFX03960.1 - 1.8e-32 110.0 8.4 2.6e-08 33.4 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 EFX03960.1 - 0.00016 19.9 0.6 0.0014 16.8 0.2 2.4 2 1 0 2 2 2 1 Nucleoporin Nup120/160 eIF2A PF08662.6 EFX03960.1 - 0.00017 21.3 0.1 0.056 13.1 0.0 2.6 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 EFX03960.1 - 0.033 13.6 0.0 0.2 11.1 0.0 2.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.11 EFX03960.1 - 0.041 12.1 0.0 2 6.6 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ric8 PF10165.4 EFX03961.1 - 1.9e-121 405.9 0.1 2.4e-121 405.6 0.1 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn CS PF04969.11 EFX03962.1 - 7.6e-07 29.5 0.1 1.6e-06 28.5 0.0 1.5 1 1 0 1 1 1 1 CS domain Fork_head_N PF08430.7 EFX03962.1 - 1.6 9.1 13.3 2.6 8.4 9.2 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region DUF3844 PF12955.2 EFX03963.1 - 5.2e-33 113.2 3.0 7.9e-33 112.6 2.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) DnaJ PF00226.26 EFX03966.1 - 5.5e-21 74.0 1.2 1e-20 73.2 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain Foie-gras_1 PF11817.3 EFX03966.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Foie gras liver health family 1 Fungal_trans PF04082.13 EFX03967.1 - 6.1e-22 77.7 0.0 1.1e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX03967.1 - 6.6e-09 35.5 11.4 1.2e-08 34.6 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FLO_LFY PF01698.11 EFX03967.1 - 0.14 10.9 3.3 2.7 6.7 3.0 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein CPSF100_C PF13299.1 EFX03967.1 - 1.2 9.3 6.4 1e+02 3.0 5.5 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Band_3_cyto PF07565.8 EFX03967.1 - 6.9 6.1 9.0 12 5.3 6.3 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Peptidase_A4 PF01828.12 EFX03968.1 - 5.6e-85 283.6 9.7 6.7e-85 283.3 6.7 1.1 1 0 0 1 1 1 1 Peptidase A4 family VCBS PF13517.1 EFX03968.1 - 5.8 7.3 10.1 9.9 6.6 0.2 3.4 3 1 1 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella USP7_ICP0_bdg PF12436.3 EFX03969.1 - 5.4e-80 268.2 0.3 2.1e-78 263.0 0.1 2.4 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 EFX03969.1 - 6.2e-66 221.8 0.6 5.8e-62 208.8 0.0 3.6 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.24 EFX03969.1 - 3.8e-53 180.3 2.5 5.4e-53 179.8 1.7 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Tim17 PF02466.14 EFX03969.1 - 2.4e-38 131.0 18.0 8.6e-38 129.2 12.5 1.9 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family UCH_1 PF13423.1 EFX03969.1 - 2.1e-28 99.6 0.1 3.4e-28 98.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 EFX03969.1 - 6.8e-15 55.3 0.0 2.9e-14 53.3 0.0 2.1 1 0 0 1 1 1 1 MATH domain YukD PF08817.5 EFX03969.1 - 0.00021 21.7 0.0 0.56 10.8 0.0 2.9 2 0 0 2 2 2 2 WXG100 protein secretion system (Wss), protein YukD Sec16_C PF12931.2 EFX03970.1 - 3.9e-91 305.7 0.0 5.1e-91 305.3 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 EFX03970.1 - 1.2e-28 99.4 0.0 2.2e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region DRMBL PF07522.9 EFX03971.1 - 6.4e-31 106.6 0.0 1.2e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 EFX03971.1 - 3.4e-11 43.0 0.0 7.2e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EFX03971.1 - 0.028 14.0 0.2 0.068 12.8 0.1 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily CRAL_TRIO PF00650.15 EFX03972.1 - 7.9e-40 135.9 0.0 1e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFX03972.1 - 1.9e-09 37.5 0.6 4e-09 36.4 0.4 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EFX03972.1 - 0.0004 20.3 0.0 0.00064 19.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain GA PF01468.12 EFX03972.1 - 0.059 13.5 0.2 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 GA module RasGEF PF00617.14 EFX03973.1 - 2.7e-43 147.9 0.3 5.8e-43 146.8 0.1 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 EFX03973.1 - 5.7e-14 52.0 0.0 1.2e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif Miro PF08477.8 EFX03973.1 - 2.3e-13 50.6 0.0 1e-12 48.6 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Ras PF00071.17 EFX03973.1 - 1.8e-06 27.4 0.0 6.7e-06 25.5 0.0 1.9 2 0 0 2 2 2 1 Ras family FtsK_SpoIIIE PF01580.13 EFX03973.1 - 0.0096 15.4 0.0 1.8 8.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.1 EFX03973.1 - 0.064 13.3 0.0 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Peptidase_M24 PF00557.19 EFX03974.1 - 1.8e-56 190.9 0.0 3.4e-56 190.1 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EFX03974.1 - 1.6e-20 72.8 0.0 6.2e-20 70.9 0.0 1.9 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain HisKA_3 PF07730.8 EFX03974.1 - 0.15 12.4 3.4 0.22 11.9 0.6 2.5 2 0 0 2 2 2 0 Histidine kinase Aminotran_4 PF01063.14 EFX03975.1 - 7.1e-23 81.2 0.0 9.3e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Fucose_iso_N1 PF07881.7 EFX03975.1 - 0.16 11.5 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 L-fucose isomerase, first N-terminal domain Ras PF00071.17 EFX03976.1 - 1.7e-51 173.8 0.0 3.3e-51 172.8 0.0 1.4 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EFX03976.1 - 7.7e-18 65.1 0.1 6.4e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EFX03976.1 - 0.00013 21.2 0.0 0.00047 19.4 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFX03976.1 - 0.0088 15.9 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 EFX03976.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.13 EFX03976.1 - 0.018 14.3 0.1 0.22 10.7 0.0 2.3 2 1 1 3 3 3 0 Ferrous iron transport protein B AAA_25 PF13481.1 EFX03976.1 - 0.083 12.2 0.2 0.23 10.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 EFX03976.1 - 0.09 11.9 0.0 0.83 8.8 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Septin PF00735.13 EFX03976.1 - 0.097 11.6 0.0 0.23 10.4 0.0 1.6 2 0 0 2 2 2 0 Septin DUF2075 PF09848.4 EFX03976.1 - 0.11 11.4 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Exo_endo_phos PF03372.18 EFX03977.1 - 1.2e-13 51.5 0.3 1.8e-13 51.0 0.2 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.11 EFX03978.1 - 1.3e-21 76.7 56.7 6.1e-12 44.9 15.0 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Herpes_LMP1 PF05297.6 EFX03978.1 - 0.24 10.2 3.2 0.18 10.7 1.1 1.5 1 1 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PMP1_2 PF08114.6 EFX03979.1 - 0.025 14.0 0.9 0.037 13.5 0.6 1.2 1 0 0 1 1 1 0 ATPase proteolipid family PspB PF06667.7 EFX03979.1 - 0.16 11.9 0.2 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 Phage shock protein B CAF-1_p150 PF11600.3 EFX03980.1 - 0.08 12.3 5.3 0.11 11.8 3.7 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PPC PF04151.10 EFX03980.1 - 1.7 9.6 4.8 3.1 8.8 3.3 1.5 1 1 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain bZIP_C PF12498.3 EFX03980.1 - 8.8 7.6 7.5 20 6.4 5.2 1.7 1 1 0 1 1 1 0 Basic leucine-zipper C terminal Kinetocho_Slk19 PF12709.2 EFX03982.1 - 2.1e-21 75.7 0.5 2.1e-21 75.7 0.4 3.9 3 1 0 3 3 3 2 Central kinetochore-associated DUF2605 PF10792.4 EFX03982.1 - 0.043 13.4 1.6 0.13 11.9 1.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) FlaC_arch PF05377.6 EFX03982.1 - 3.6 7.5 15.2 0.12 12.3 0.9 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) adh_short PF00106.20 EFX03983.1 - 4.7e-05 23.3 0.0 5.1e-05 23.2 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase Vps26 PF03643.10 EFX03984.1 - 1.6e-130 433.8 0.6 1.8e-130 433.6 0.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 EFX03984.1 - 0.0003 20.6 0.3 0.45 10.3 0.1 3.7 2 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain HEAT PF02985.17 EFX03985.1 - 2.5e-06 27.0 0.1 1 9.6 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat DUF2413 PF10310.4 EFX03985.1 - 0.41 9.4 3.2 0.81 8.4 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) GSIII_N PF12437.3 EFX03986.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal PfkB PF00294.19 EFX03987.1 - 3.2e-12 46.1 0.0 5e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase FAD_binding_3 PF01494.14 EFX03988.1 - 3.6e-15 55.8 0.4 2.9e-09 36.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_9 PF13454.1 EFX03988.1 - 0.0003 20.5 0.2 0.003 17.3 0.1 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EFX03988.1 - 0.00077 19.5 0.1 0.0023 18.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX03988.1 - 0.0049 16.7 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX03988.1 - 0.0055 16.7 0.0 0.022 14.7 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFX03988.1 - 0.11 10.9 0.0 0.26 9.7 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein RNA_pol_3_Rpc31 PF11705.3 EFX03989.1 - 3.3e-34 118.8 22.3 4.3e-33 115.1 15.5 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Glyco_transf_20 PF00982.16 EFX03990.1 - 2.4e-141 471.4 0.0 3.4e-141 470.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EFX03990.1 - 1.6e-74 249.7 0.1 2.6e-72 242.5 0.0 2.2 1 1 0 1 1 1 1 Trehalose-phosphatase AAA PF00004.24 EFX03991.1 - 6e-20 71.7 0.0 1.1e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EFX03991.1 - 0.0017 18.6 0.1 0.044 14.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX03991.1 - 0.002 18.2 0.0 0.0073 16.4 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EFX03991.1 - 0.0074 16.2 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EFX03991.1 - 0.0077 17.0 0.5 0.055 14.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EFX03991.1 - 0.01 15.5 0.0 0.032 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zot PF05707.7 EFX03991.1 - 0.041 13.3 0.1 0.27 10.6 0.1 2.2 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_14 PF13173.1 EFX03991.1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EFX03991.1 - 0.073 12.4 0.1 0.27 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.7 EFX03991.1 - 0.083 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 EFX03991.1 - 0.22 10.1 0.0 0.34 9.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus GHMP_kinases_N PF00288.21 EFX03993.1 - 4.9e-12 45.7 0.0 1e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFX03993.1 - 1.4e-06 28.4 0.0 3.1e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal ETC_C1_NDUFA4 PF04800.7 EFX03994.1 - 1.9e-35 120.7 2.0 2.7e-35 120.2 1.4 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region HA2 PF04408.18 EFX03995.1 - 3.6e-17 62.2 0.0 1e-16 60.8 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFX03995.1 - 1.3e-12 47.4 0.0 3.3e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFX03995.1 - 2.1e-10 40.3 0.0 3.9e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EFX03995.1 - 1.7e-07 31.4 2.0 3.5e-07 30.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain OB_NTP_bind PF07717.11 EFX03995.1 - 6.8e-06 25.8 0.0 1.5e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_29 PF13555.1 EFX03995.1 - 0.02 14.4 0.0 0.061 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 EFX03995.1 - 0.026 14.8 0.0 0.17 12.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter KaiC PF06745.8 EFX03995.1 - 0.048 12.7 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.17 EFX03995.1 - 0.052 12.4 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Virulence_fact PF13769.1 EFX03995.1 - 0.49 10.2 6.1 1.5 8.7 4.2 1.8 1 0 0 1 1 1 0 Virulence factor SWI-SNF_Ssr4 PF08549.5 EFX03997.1 - 5.2e-179 596.7 27.4 1.4e-176 588.7 19.0 3.1 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) DUF1688 PF07958.6 EFX03998.1 - 8.6e-160 531.8 0.0 9.7e-160 531.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Zn_clus PF00172.13 EFX03999.1 - 3.5e-06 26.8 10.0 5.4e-06 26.2 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexokinase_2 PF03727.11 EFX04000.1 - 5.9e-86 287.6 0.0 8.2e-86 287.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 EFX04000.1 - 2.6e-74 249.0 0.0 4.6e-74 248.1 0.0 1.4 1 0 0 1 1 1 1 Hexokinase PKD_channel PF08016.7 EFX04001.1 - 3.5e-06 25.7 16.9 2.1e-05 23.1 11.7 1.9 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 EFX04001.1 - 0.00054 19.2 21.2 0.002 17.4 7.3 2.3 2 0 0 2 2 2 2 Ion transport protein DSPn PF14671.1 EFX04003.1 - 6.7e-43 146.0 0.0 1.5e-40 138.4 0.0 2.8 2 1 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 EFX04003.1 - 4.4e-16 58.6 0.0 1.1e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFX04003.1 - 7.2e-07 28.7 0.0 1.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.8 EFX04003.1 - 0.019 14.3 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.1 EFX04003.1 - 0.024 14.7 1.5 0.037 14.0 0.0 2.1 2 1 0 2 2 2 0 Inositol hexakisphosphate CDKN3 PF05706.7 EFX04003.1 - 0.034 13.6 0.1 0.068 12.6 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) IDO PF01231.13 EFX04004.1 - 9.2e-159 528.3 0.0 1.1e-158 528.1 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase AIG2 PF06094.7 EFX04005.1 - 0.0062 17.0 0.0 0.0085 16.5 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family Aldedh PF00171.17 EFX04006.1 - 8.2e-124 413.4 3.8 8.1e-83 278.2 1.2 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family LuxC PF05893.9 EFX04006.1 - 8.1e-06 24.8 0.0 1.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) Tyr_Deacylase PF02580.11 EFX04007.1 - 2.1e-45 154.2 0.1 2.4e-45 154.0 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase GATA PF00320.22 EFX04008.1 - 1.9e-14 52.6 2.2 3.3e-14 51.9 1.5 1.4 1 0 0 1 1 1 1 GATA zinc finger HlyD PF00529.15 EFX04008.1 - 0.0038 16.5 2.6 0.0038 16.5 1.8 2.2 2 0 0 2 2 2 1 HlyD family secretion protein DUF2630 PF10944.3 EFX04008.1 - 0.5 10.5 5.0 1.8 8.7 3.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) Pribosyl_synth PF14572.1 EFX04009.1 - 1e-40 139.4 1.1 1.8e-34 119.0 0.2 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 EFX04009.1 - 6.4e-31 106.4 0.0 2.1e-30 104.8 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 EFX04009.1 - 3.7e-12 46.0 0.1 8.8e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GTP_CH_N PF12471.3 EFX04010.1 - 5.2e-89 297.0 0.0 9.7e-89 296.1 0.0 1.4 2 0 0 2 2 2 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 EFX04010.1 - 8.6e-18 64.1 0.0 1.4e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II TIMELESS_C PF05029.8 EFX04011.1 - 9.1e-16 57.8 43.5 7.4e-14 51.5 30.1 3.0 1 1 0 1 1 1 1 Timeless protein C terminal region Acyl-CoA_ox_N PF14749.1 EFX04011.1 - 0.66 10.2 3.8 0.51 10.6 0.9 2.1 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Med24_N PF11277.3 EFX04011.1 - 3.8 4.8 4.1 5.3 4.3 2.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal CTP_transf_2 PF01467.21 EFX04012.1 - 8.9e-21 74.5 0.2 2.3e-20 73.2 0.0 1.8 2 0 0 2 2 2 1 Cytidylyltransferase MFS_1 PF07690.11 EFX04014.1 - 3.9e-30 104.7 23.7 3.9e-30 104.7 16.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Ctr PF04145.10 EFX04014.1 - 0.0045 17.0 0.1 0.052 13.5 0.0 2.7 3 0 0 3 3 3 1 Ctr copper transporter family DUF1180 PF06679.7 EFX04014.1 - 0.013 15.4 0.0 0.034 14.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Cwf_Cwc_15 PF04889.7 EFX04014.1 - 0.014 15.0 9.3 0.056 13.1 0.7 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TraP PF07296.6 EFX04014.1 - 0.031 13.2 0.3 0.28 10.1 0.0 2.3 2 0 0 2 2 2 0 TraP protein Myc_N PF01056.13 EFX04014.1 - 1.9 7.5 7.2 3.2 6.8 0.3 2.1 2 0 0 2 2 2 0 Myc amino-terminal region FAM176 PF14851.1 EFX04014.1 - 2.4 7.8 6.8 13 5.4 0.1 2.6 3 0 0 3 3 3 0 FAM176 family PRiA4_ORF3 PF07929.6 EFX04015.1 - 6.7e-12 45.1 0.0 9.3e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein zf-MYND PF01753.13 EFX04015.1 - 6.2e-11 41.9 13.8 1.1e-10 41.1 9.5 1.5 1 0 0 1 1 1 1 MYND finger Meleagrin PF08189.6 EFX04015.1 - 0.074 12.5 2.9 0.17 11.3 2.0 1.7 1 0 0 1 1 1 0 Meleagrin/Cygnin family But2 PF09792.4 EFX04015.1 - 0.78 9.4 3.9 0.92 9.2 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin 3 binding protein But2 C-terminal domain Peptidase_M3 PF01432.15 EFX04017.1 - 1.5e-108 363.7 0.0 2.3e-108 363.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 EFX04017.1 - 0.054 12.8 0.2 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like p450 PF00067.17 EFX04018.1 - 8.2e-48 163.0 0.0 1.1e-47 162.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S10 PF00450.17 EFX04019.1 - 1.6e-87 294.4 0.1 2.3e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase GRAM PF02893.15 EFX04020.1 - 0.044 13.3 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 GRAM domain Mnd1 PF03962.10 EFX04020.1 - 0.19 11.3 1.8 1.1 8.9 0.4 2.5 2 0 0 2 2 2 0 Mnd1 family Glyco_hydro_61 PF03443.9 EFX04021.1 - 8.4e-79 264.3 0.2 8.4e-79 264.3 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 Rifin_STEVOR PF02009.11 EFX04021.1 - 8.8 5.8 9.8 12 5.4 6.8 1.2 1 0 0 1 1 1 0 Rifin/stevor family Pkinase PF00069.20 EFX04022.1 - 2.9e-61 206.9 0.0 2.3e-38 131.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04022.1 - 1.4e-26 93.1 0.0 1.2e-19 70.3 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.19 EFX04022.1 - 2.1e-13 50.2 0.1 4.4e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.1 EFX04022.1 - 2.2e-07 30.1 0.0 5.3e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EFX04022.1 - 5.9e-06 26.1 0.0 0.0073 16.0 0.1 2.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family PAS_9 PF13426.1 EFX04022.1 - 0.00018 21.8 0.0 0.0005 20.4 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 EFX04022.1 - 0.016 14.9 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 0 PAS fold Kdo PF06293.9 EFX04022.1 - 0.053 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 EFX04022.1 - 0.34 9.7 0.0 0.59 8.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 zf-CCHC PF00098.18 EFX04023.1 - 3e-41 137.4 56.9 2e-07 30.6 1.3 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 EFX04023.1 - 1.5e-10 40.5 41.3 0.076 12.6 0.7 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.1 EFX04023.1 - 2.7e-05 23.7 41.8 0.23 11.2 0.7 6.9 5 2 1 6 6 6 5 Zinc knuckle zf-CCHC_2 PF13696.1 EFX04023.1 - 0.082 12.4 0.4 0.082 12.4 0.3 7.1 4 2 3 7 7 7 0 Zinc knuckle zf-CCHC_6 PF15288.1 EFX04023.1 - 0.11 12.1 0.1 0.11 12.1 0.1 6.8 6 1 1 7 7 7 0 Zinc knuckle DUF836 PF05768.9 EFX04024.1 - 4.8e-13 49.1 0.0 5.7e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 EFX04024.1 - 0.00018 21.4 0.0 0.0003 20.7 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin ADH_zinc_N PF00107.21 EFX04025.1 - 1e-32 112.3 0.5 1.6e-32 111.8 0.4 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX04025.1 - 1.7e-08 35.4 0.1 4.2e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX04025.1 - 2.4e-07 30.4 0.0 7e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TRAUB PF08164.7 EFX04026.1 - 2.3e-29 101.3 0.1 2.3e-29 101.3 0.0 2.6 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.1 EFX04026.1 - 7.7e-26 90.7 1.8 7.7e-26 90.7 1.3 2.3 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor EMP24_GP25L PF01105.19 EFX04027.1 - 2.2e-41 141.5 0.0 2.7e-41 141.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RRXRR PF14239.1 EFX04027.1 - 0.077 12.4 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 RRXRR protein Glyco_hydro_12 PF01670.11 EFX04028.1 - 5.2e-12 45.8 1.3 5.2e-12 45.8 0.9 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 12 zf-CCCH PF00642.19 EFX04029.1 - 0.0029 17.2 0.2 0.0029 17.2 0.1 2.2 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EFX04029.1 - 0.054 13.5 0.4 0.054 13.5 0.3 3.2 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type TFIIA PF03153.8 EFX04029.1 - 3.5 7.4 5.7 5.9 6.6 3.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 6PGD PF00393.14 EFX04030.1 - 2e-133 444.0 0.0 2.5e-133 443.7 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EFX04030.1 - 4.4e-51 172.9 0.0 7e-51 172.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 EFX04030.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PGK PF00162.14 EFX04030.1 - 0.11 11.0 0.0 0.18 10.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoglycerate kinase Fungal_trans PF04082.13 EFX04032.1 - 1.7e-11 43.4 0.1 2.7e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04032.1 - 1.4e-07 31.2 7.3 1.4e-07 31.2 5.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.8 EFX04032.1 - 0.082 12.9 0.6 0.24 11.4 0.4 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2076 PF09849.4 EFX04032.1 - 0.2 11.7 4.3 0.39 10.7 3.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Asp PF00026.18 EFX04034.1 - 1.4e-41 142.7 0.1 1.8e-41 142.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX04034.1 - 7.9e-05 22.6 0.6 0.00092 19.1 0.2 2.5 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFX04034.1 - 0.088 13.3 0.2 5.2 7.6 0.0 2.6 2 0 0 2 2 2 0 Aspartyl protease ILVD_EDD PF00920.16 EFX04035.1 - 9.1e-149 496.2 1.5 1.1e-148 495.9 1.0 1.0 1 0 0 1 1 1 1 Dehydratase family Fungal_trans PF04082.13 EFX04036.1 - 3.2e-14 52.4 0.0 5.2e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04036.1 - 2.4e-09 36.9 5.5 6.8e-09 35.5 3.8 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rep_fac-A_3 PF08661.6 EFX04037.1 - 1e-18 67.2 0.1 1.1e-18 67.0 0.1 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 tRNA_anti-like PF12869.2 EFX04037.1 - 0.1 12.0 0.4 0.15 11.5 0.2 1.4 1 1 0 1 1 1 0 tRNA_anti-like AA_permease_2 PF13520.1 EFX04038.1 - 4.2e-63 213.3 35.4 6.8e-63 212.6 24.5 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX04038.1 - 1.3e-28 99.6 27.9 1.3e-28 99.6 19.4 2.2 2 0 0 2 2 2 1 Amino acid permease WD40 PF00400.27 EFX04039.1 - 1.4e-51 170.5 19.7 2.9e-12 45.9 0.4 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 EFX04039.1 - 1.4e-05 23.4 6.3 0.0077 14.4 0.1 3.4 3 2 0 3 3 3 2 Nucleoporin Nup120/160 MIP-T3 PF10243.4 EFX04039.1 - 0.0047 15.4 12.1 0.0059 15.1 8.4 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Nucleoporin_N PF08801.6 EFX04039.1 - 0.0049 15.6 0.7 0.52 8.9 0.3 3.0 2 2 0 2 2 2 1 Nup133 N terminal like DUF3312 PF11768.3 EFX04039.1 - 0.0059 14.8 0.0 0.073 11.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3312) Apc4_WD40 PF12894.2 EFX04039.1 - 0.029 13.8 0.0 4.7 6.8 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 EFX04039.1 - 0.092 10.5 0.0 0.14 9.9 0.0 1.2 1 0 0 1 1 1 0 IKI3 family PD40 PF07676.7 EFX04039.1 - 0.12 12.0 0.4 24 4.6 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Sporozoite_P67 PF05642.6 EFX04039.1 - 1.7 6.4 7.2 2.7 5.7 5.0 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_Rpc34 PF05158.7 EFX04040.1 - 1.7e-94 316.7 0.0 2.2e-94 316.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.6 EFX04040.1 - 0.0026 18.1 1.0 0.073 13.4 0.0 3.2 3 1 1 4 4 4 1 Replication protein A C terminal B-block_TFIIIC PF04182.7 EFX04040.1 - 0.0049 16.6 0.2 0.014 15.2 0.1 1.8 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_34 PF13601.1 EFX04040.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF787 PF05619.6 EFX04040.1 - 0.11 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) RRM_1 PF00076.17 EFX04041.1 - 6.7e-16 57.6 0.0 1.1e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX04041.1 - 8.6e-12 44.8 0.0 1.4e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX04041.1 - 0.00027 20.7 0.0 0.00051 19.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) adh_short PF00106.20 EFX04042.1 - 7.7e-22 77.9 0.6 1.1e-21 77.4 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04042.1 - 7e-11 42.3 0.1 9.5e-11 41.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX04042.1 - 2.5e-09 37.0 0.1 4.2e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EFX04042.1 - 0.00027 19.9 0.1 0.074 11.9 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Epimerase PF01370.16 EFX04042.1 - 0.0022 17.4 0.9 0.06 12.7 0.6 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pro_CA PF00484.14 EFX04043.1 - 9.4e-49 165.3 0.0 1.4e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 Carbonic anhydrase Methyltransf_23 PF13489.1 EFX04044.1 - 2.3e-13 50.1 0.0 3.5e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04044.1 - 5.2e-07 30.0 0.0 2e-05 24.9 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04044.1 - 6.2e-06 26.5 0.0 0.00023 21.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04044.1 - 7.9e-06 26.2 0.0 0.0001 22.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX04044.1 - 0.00031 19.9 0.0 0.011 14.8 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFX04044.1 - 0.0021 18.1 0.3 0.0047 16.9 0.2 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04044.1 - 0.0026 17.3 0.0 1.4 8.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04044.1 - 0.0027 18.2 0.0 0.01 16.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain SURF6 PF04935.7 EFX04045.1 - 1.8e-29 102.6 32.2 2.6e-16 59.5 10.4 5.5 3 2 1 4 4 4 2 Surfeit locus protein 6 RRP14 PF15459.1 EFX04045.1 - 2.5e-20 72.3 0.3 2.5e-20 72.3 0.2 6.9 4 2 1 5 5 5 1 60S ribosome biogenesis protein Rrp14 GHMP_kinases_N PF00288.21 EFX04046.1 - 1.1e-19 70.2 0.0 2.6e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EFX04046.1 - 5.1e-10 39.4 0.0 1.1e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.4 EFX04046.1 - 0.053 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Galactokinase galactose-binding signature DUF1525 PF07511.6 EFX04046.1 - 0.08 12.9 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) DUF1965 PF09248.5 EFX04047.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) HIT PF01230.18 EFX04048.1 - 3.6e-23 81.9 0.1 4.7e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 EFX04048.1 - 2e-15 56.9 0.1 4.4e-15 55.9 0.0 1.5 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EFX04048.1 - 2.6e-05 23.8 0.3 4.2e-05 23.1 0.0 1.4 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 DUF3112 PF11309.3 EFX04049.1 - 2.7e-48 163.7 14.6 4.2e-45 153.4 0.4 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) HET PF06985.6 EFX04051.1 - 3.9e-20 72.4 9.8 3.5e-17 62.8 0.7 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Jacalin PF01419.12 EFX04051.1 - 1.1e-07 31.8 0.0 1.8e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Jacalin-like lectin domain RasGAP PF00616.14 EFX04052.1 - 3.4e-43 147.6 0.9 1e-42 146.0 0.0 2.2 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 EFX04052.1 - 0.00017 21.3 0.0 0.00036 20.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain RR_TM4-6 PF06459.7 EFX04052.1 - 5.1 6.9 8.5 10 5.9 5.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PGAP1 PF07819.8 EFX04053.1 - 7.5e-90 300.4 0.0 1.2e-89 299.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 EFX04053.1 - 1.2e-07 31.5 0.0 2.4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX04053.1 - 3.8e-05 23.6 1.1 5.7e-05 23.1 0.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX04053.1 - 0.004 16.7 0.0 0.021 14.3 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF676 PF05057.9 EFX04053.1 - 0.12 11.5 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) CDC14 PF08045.6 EFX04054.1 - 1.5e-93 312.6 0.0 1.6e-93 312.5 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component DUF1479 PF07350.7 EFX04056.1 - 4e-98 328.6 0.0 5.1e-98 328.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) zf-CCCH PF00642.19 EFX04057.1 - 0.0047 16.5 24.2 0.15 11.7 0.0 5.4 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) 3HCDH_N PF02737.13 EFX04058.1 - 1.1e-54 184.8 2.1 1.4e-54 184.5 1.5 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 EFX04058.1 - 1e-32 112.3 0.0 2.1e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EFX04058.1 - 2.8e-05 24.0 0.6 6.1e-05 22.9 0.4 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.19 EFX04058.1 - 0.0013 17.7 1.3 0.0019 17.1 0.5 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX04058.1 - 0.031 14.1 0.1 0.042 13.7 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 EFX04058.1 - 0.043 12.9 0.2 0.091 11.9 0.1 1.6 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EFX04058.1 - 0.047 14.1 0.6 0.047 14.1 0.4 2.2 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.22 EFX04058.1 - 0.071 13.5 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EFX04058.1 - 0.082 12.2 0.1 0.2 11.0 0.1 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.1 EFX04058.1 - 0.1 12.6 2.4 0.38 10.7 1.4 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 EFX04058.1 - 0.14 11.8 3.5 0.36 10.5 2.4 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus zf-CCCH_2 PF14608.1 EFX04059.1 - 0.022 14.7 1.5 0.041 13.8 1.0 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Ycf1 PF05758.7 EFX04059.1 - 0.1 10.3 11.0 0.22 9.2 7.6 1.5 1 0 0 1 1 1 0 Ycf1 zf-CCCH PF00642.19 EFX04059.1 - 0.25 11.0 1.4 0.45 10.2 1.0 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zip PF02535.17 EFX04059.1 - 2.4 7.0 4.6 6.4 5.6 3.2 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter Asparaginase_2 PF01112.13 EFX04060.1 - 1e-36 126.2 4.0 9.4e-19 67.2 0.1 3.4 4 0 0 4 4 4 3 Asparaginase Pil1 PF13805.1 EFX04061.1 - 5.4e-103 343.8 2.2 7e-103 343.4 1.5 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 SH3_9 PF14604.1 EFX04062.1 - 4.8e-08 32.4 0.1 1.5e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 EFX04062.1 - 0.0052 16.2 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFX04062.1 - 0.028 13.7 0.1 0.065 12.6 0.0 1.6 1 0 0 1 1 1 0 SH3 domain TPR_12 PF13424.1 EFX04063.1 - 5.5e-16 58.2 0.5 1.3e-12 47.4 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 EFX04063.1 - 4.9e-13 48.5 3.4 3e-06 26.9 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 EFX04063.1 - 2.5e-06 27.7 1.3 0.019 15.3 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX04063.1 - 6.7e-06 26.6 1.6 0.00055 20.5 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 EFX04063.1 - 9.4e-06 25.0 1.4 0.062 13.1 0.0 4.0 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.9 EFX04063.1 - 0.00054 20.1 1.3 8.8 7.0 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX04063.1 - 0.00077 19.1 0.1 7.5 6.7 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EFX04063.1 - 0.0019 18.6 3.6 1.6 9.5 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EFX04063.1 - 0.018 14.6 0.1 4.4 7.0 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX04063.1 - 0.026 14.9 0.3 51 4.6 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_43 PF04616.9 EFX04064.1 - 1.9e-25 89.5 0.0 2.7e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF3883 PF13020.1 EFX04064.1 - 0.16 11.7 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) CorA PF01544.13 EFX04065.1 - 0.00053 19.1 0.1 0.027 13.5 0.0 2.5 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Flu_M2 PF00599.12 EFX04065.1 - 0.056 13.2 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 Influenza Matrix protein (M2) Ribosomal_L6 PF00347.18 EFX04066.1 - 1.5e-26 92.7 6.4 6.6e-14 52.1 1.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Glyco_tranf_2_3 PF13641.1 EFX04067.1 - 3e-33 115.5 0.0 4.2e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFX04067.1 - 3.9e-21 75.6 0.4 3.9e-21 75.6 0.3 2.3 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.9 EFX04067.1 - 6e-12 44.6 7.2 2.1e-09 36.2 4.1 2.5 1 1 2 3 3 3 2 Cellulose synthase Glycos_transf_2 PF00535.21 EFX04067.1 - 1.3e-11 44.4 0.0 2.8e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 EFX04067.1 - 1.1e-09 37.8 0.0 1.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.10 EFX04067.1 - 0.0036 15.7 0.0 0.09 11.1 0.0 2.2 2 0 0 2 2 2 1 Chitin synthase DUF4510 PF14971.1 EFX04067.1 - 0.086 13.0 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4510) dsrm PF00035.20 EFX04068.1 - 0.026 15.0 0.0 0.038 14.5 0.0 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding motif DUF3328 PF11807.3 EFX04069.1 - 1.5e-51 175.1 3.0 2e-51 174.7 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Fungal_trans PF04082.13 EFX04070.1 - 2.6e-13 49.4 0.0 1.7e-12 46.7 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04070.1 - 4.3e-07 29.7 8.8 9.1e-07 28.6 6.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1793 PF08760.6 EFX04071.1 - 1.3e-60 204.2 0.2 2.8e-60 203.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF3458 PF11940.3 EFX04071.1 - 0.046 12.5 0.2 0.079 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Phosphorylase PF00343.15 EFX04072.1 - 0 1078.3 0.5 0 1078.0 0.3 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DHquinase_II PF01220.14 EFX04072.1 - 0.11 11.7 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Dehydroquinase class II GST_N_3 PF13417.1 EFX04073.1 - 2.4e-05 24.4 0.0 4.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFX04073.1 - 2.8e-05 24.2 0.0 5.9e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EFX04073.1 - 0.00043 20.7 0.0 0.00077 19.9 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFX04073.1 - 0.00068 19.4 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFX04073.1 - 0.0014 18.5 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EFX04073.1 - 0.0029 17.5 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.11 EFX04075.1 - 1.1e-30 106.6 60.9 6.4e-25 87.6 26.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX04075.1 - 5.8e-20 71.3 22.3 7.8e-14 51.0 6.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter DUF1754 PF08555.5 EFX04076.1 - 2.8e-09 37.4 11.5 5.6e-09 36.4 8.0 1.5 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) CMV_1a PF12467.3 EFX04076.1 - 0.17 12.2 3.1 0.22 11.9 2.1 1.2 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family AA_permease PF00324.16 EFX04077.1 - 1.1e-56 192.1 32.0 1.4e-56 191.8 22.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX04077.1 - 1.6e-15 56.6 38.4 2.2e-15 56.1 26.6 1.1 1 0 0 1 1 1 1 Amino acid permease Helicase_C_2 PF13307.1 EFX04078.1 - 1.1e-60 204.3 0.0 2.9e-60 203.0 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 EFX04078.1 - 2.2e-39 134.6 0.0 5.9e-39 133.2 0.0 1.7 1 1 0 1 1 1 1 DEAD_2 PhoH PF02562.11 EFX04078.1 - 0.06 12.5 0.1 9.2 5.4 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Nop14 PF04147.7 EFX04078.1 - 0.08 10.8 13.8 0.12 10.2 9.6 1.2 1 0 0 1 1 1 0 Nop14-like family AAA_19 PF13245.1 EFX04078.1 - 0.089 12.5 3.5 0.065 12.9 0.3 2.6 2 1 0 2 2 2 0 Part of AAA domain ResIII PF04851.10 EFX04078.1 - 0.15 11.8 0.0 20 4.9 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit BTV_NS2 PF04514.7 EFX04078.1 - 1.3 7.8 7.5 2.3 7.0 5.2 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 FHA PF00498.21 EFX04079.1 - 8.5e-11 41.8 0.0 1.4e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 FHA domain Ist1 PF03398.9 EFX04080.1 - 2.1e-62 209.4 0.3 2.1e-62 209.4 0.2 1.8 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway GRAM PF02893.15 EFX04081.1 - 8.4e-29 98.8 0.4 2.2e-15 55.9 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.15 EFX04081.1 - 1.3e-27 96.2 0.0 2.7e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.24 EFX04081.1 - 1.3e-13 51.0 0.0 4.6e-13 49.2 0.0 2.1 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EFX04081.1 - 0.00029 21.0 0.3 0.0026 17.9 0.2 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.1 EFX04081.1 - 0.0012 18.6 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 EFX04081.1 - 0.0023 17.9 0.0 0.0059 16.6 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain UDPGT PF00201.13 EFX04081.1 - 0.02 13.4 0.0 0.036 12.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase zf-H2C2_2 PF13465.1 EFX04082.1 - 5.8e-13 48.4 19.3 7.4e-07 29.1 1.5 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EFX04082.1 - 1.9e-10 40.4 23.2 0.0023 18.1 2.7 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX04082.1 - 1.8e-06 27.8 24.6 0.0089 16.3 4.1 3.7 4 0 0 4 4 3 3 C2H2-type zinc finger zf-CHCC PF10276.4 EFX04082.1 - 0.012 15.3 5.8 1.6 8.6 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger domain zf-C2H2_6 PF13912.1 EFX04082.1 - 0.1 12.5 0.0 0.1 12.5 0.0 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger Met_synt_B12 PF02965.12 EFX04082.1 - 0.17 11.0 2.1 0.32 10.1 1.4 1.4 1 0 0 1 1 1 0 Vitamin B12 dependent methionine synthase, activation domain Zn-ribbon_8 PF09723.5 EFX04082.1 - 0.26 11.2 6.9 9.4 6.2 0.1 2.9 2 1 0 2 2 2 0 Zinc ribbon domain PyrI_C PF02748.10 EFX04082.1 - 0.3 10.5 2.7 0.25 10.8 0.4 1.9 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2225 PF09986.4 EFX04082.1 - 0.36 10.2 1.5 0.89 8.9 0.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-RING_3 PF14369.1 EFX04082.1 - 0.39 10.7 5.2 13 5.8 0.1 2.8 2 1 0 2 2 2 0 zinc-finger zf-Di19 PF05605.7 EFX04082.1 - 0.81 9.8 11.2 6.2 7.0 4.5 3.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.6 EFX04082.1 - 1.7 8.2 5.6 8.4 6.0 0.1 2.9 1 1 2 3 3 3 0 GAGA factor MFS_1 PF07690.11 EFX04083.1 - 8.8e-19 67.4 18.5 1.4e-18 66.8 12.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MMTV_SAg PF01054.12 EFX04083.1 - 0.047 12.5 0.0 0.079 11.8 0.0 1.3 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen DUF4500 PF14937.1 EFX04083.1 - 0.44 10.4 2.6 0.27 11.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) PPTA PF01239.17 EFX04084.1 - 2.2e-36 121.6 11.5 2.6e-07 29.7 0.1 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Asp_Glu_race PF01177.17 EFX04085.1 - 0.00054 19.9 0.2 0.49 10.2 0.0 2.1 1 1 1 2 2 2 2 Asp/Glu/Hydantoin racemase IF-2B PF01008.12 EFX04086.1 - 2.6e-31 108.6 0.0 5.1e-30 104.4 0.0 2.5 1 1 0 1 1 1 1 Initiation factor 2 subunit family Metallothio_PEC PF02068.11 EFX04087.1 - 0.0022 18.3 18.1 0.071 13.4 4.2 2.6 2 0 0 2 2 2 2 Plant PEC family metallothionein Metallothio_2 PF01439.13 EFX04087.1 - 0.0024 18.3 12.4 0.052 14.0 0.8 2.6 2 0 0 2 2 2 2 Metallothionein ELO PF01151.13 EFX04088.1 - 1.5e-78 263.5 7.1 1.8e-78 263.2 4.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family TFIIF_alpha PF05793.7 EFX04089.1 - 0.00022 19.7 61.2 0.0011 17.4 7.2 3.1 2 1 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA PF00004.24 EFX04090.1 - 4.1e-14 52.9 0.0 9e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFX04090.1 - 6.2e-05 23.7 0.1 0.00053 20.7 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 EFX04090.1 - 0.00019 21.5 0.0 0.00073 19.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX04090.1 - 0.00024 21.1 0.1 0.0012 18.8 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 EFX04090.1 - 0.0038 16.9 0.0 0.0079 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 EFX04090.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFX04090.1 - 0.045 14.0 0.1 0.18 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EFX04090.1 - 0.15 11.5 0.1 0.87 9.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 EFX04090.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain SRP54 PF00448.17 EFX04090.1 - 0.17 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain HLH PF00010.21 EFX04091.1 - 3.1e-13 49.1 0.0 9.2e-13 47.6 0.0 1.8 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sugar_tr PF00083.19 EFX04092.1 - 4.7e-72 242.9 27.1 5.4e-72 242.7 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04092.1 - 7.1e-19 67.7 36.8 9.5e-11 40.9 10.2 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.1 EFX04092.1 - 4.4e-05 22.0 6.4 4.4e-05 22.0 4.4 3.1 3 1 0 3 3 3 2 MFS/sugar transport protein PUF PF00806.14 EFX04094.1 - 2.2e-08 33.0 0.0 0.13 11.7 0.0 5.0 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat SYF2 PF08231.7 EFX04095.1 - 2.7e-46 157.4 13.6 2.7e-46 157.4 9.4 2.0 2 0 0 2 2 2 1 SYF2 splicing factor SUKH-3 PF14433.1 EFX04095.1 - 0.097 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 SUKH-3 immunity protein TIP49 PF06068.8 EFX04096.1 - 3.7e-186 618.6 0.2 4.3e-186 618.4 0.2 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 EFX04096.1 - 1.9e-10 41.0 1.6 4.3e-07 30.2 0.1 2.6 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFX04096.1 - 2.9e-09 36.3 2.0 1.1e-06 27.8 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFX04096.1 - 3.1e-05 23.6 0.2 9.4e-05 22.0 0.2 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 EFX04096.1 - 7e-05 22.9 0.3 0.27 11.3 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX04096.1 - 0.00016 21.7 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.1 EFX04096.1 - 0.00051 20.0 0.2 0.0012 18.8 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EFX04096.1 - 0.0014 18.0 0.0 0.0068 15.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EFX04096.1 - 0.0032 17.1 0.2 0.11 12.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EFX04096.1 - 0.0043 16.1 0.3 0.013 14.5 0.2 1.8 1 0 0 1 1 1 1 Zeta toxin IstB_IS21 PF01695.12 EFX04096.1 - 0.0084 15.5 0.2 0.021 14.2 0.1 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 EFX04096.1 - 0.0092 15.1 0.1 0.37 9.9 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EFX04096.1 - 0.017 14.6 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF2075 PF09848.4 EFX04096.1 - 0.017 14.1 0.1 0.06 12.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.1 EFX04096.1 - 0.018 15.3 0.1 0.05 13.9 0.1 1.9 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.10 EFX04096.1 - 0.02 13.7 0.0 0.042 12.7 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_33 PF13671.1 EFX04096.1 - 0.068 13.0 0.1 0.73 9.7 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_17 PF13207.1 EFX04096.1 - 0.071 13.9 0.1 0.21 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Pcc1 PF09341.5 EFX04097.1 - 3.3e-26 91.1 0.3 4.3e-26 90.7 0.2 1.2 1 0 0 1 1 1 1 Transcription factor Pcc1 Longin PF13774.1 EFX04099.1 - 7.4e-25 86.3 0.2 1.2e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 EFX04099.1 - 1.2e-13 50.4 0.0 2e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.7 EFX04099.1 - 0.11 12.2 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Methyltransf_11 PF08241.7 EFX04100.1 - 3.7e-13 49.7 0.4 2.6e-12 47.0 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX04100.1 - 0.00014 21.6 0.0 0.00034 20.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04100.1 - 0.00024 21.4 0.1 0.0017 18.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04100.1 - 0.0012 19.4 0.0 0.0049 17.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX04100.1 - 0.062 12.3 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.10 EFX04100.1 - 0.27 10.8 0.0 0.69 9.5 0.0 1.6 2 0 0 2 2 2 0 Hypothetical methyltransferase Pro_isomerase PF00160.16 EFX04101.1 - 1.2e-36 126.3 0.2 1.4e-36 126.0 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PhnA PF03831.9 EFX04101.1 - 0.033 13.6 0.2 0.061 12.7 0.1 1.4 1 0 0 1 1 1 0 PhnA protein zf-MYND PF01753.13 EFX04102.1 - 3.4e-10 39.6 10.9 5.3e-10 38.9 7.5 1.3 1 0 0 1 1 1 1 MYND finger zinc_ribbon_4 PF13717.1 EFX04102.1 - 0.013 15.2 1.4 0.97 9.1 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon domain FdhE PF04216.7 EFX04102.1 - 0.023 14.4 3.3 0.032 13.9 2.3 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zinc_ribbon_5 PF13719.1 EFX04102.1 - 0.076 12.6 3.5 0.9 9.1 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain MFS_1 PF07690.11 EFX04103.1 - 8.5e-33 113.5 46.0 4.4e-27 94.7 15.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX04103.1 - 9.1e-10 37.6 11.9 1.3e-07 30.6 2.7 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_2 PF13347.1 EFX04103.1 - 4e-07 28.7 17.6 1.1e-05 24.0 4.6 2.9 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 EFX04103.1 - 6.6e-05 22.6 1.1 0.0023 17.6 0.1 2.7 2 0 0 2 2 2 1 MFS_1 like family OATP PF03137.15 EFX04103.1 - 0.0027 15.8 1.3 0.84 7.6 0.1 3.5 5 0 0 5 5 5 2 Organic Anion Transporter Polypeptide (OATP) family FA_desaturase PF00487.19 EFX04103.1 - 0.02 14.3 0.3 0.02 14.3 0.2 2.7 1 1 1 2 2 2 0 Fatty acid desaturase PBP1_TM PF14812.1 EFX04103.1 - 0.021 15.0 0.1 0.049 13.9 0.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2061 PF09834.4 EFX04103.1 - 0.028 14.6 1.6 5.8 7.1 0.0 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2061) TRI12 PF06609.8 EFX04103.1 - 0.24 9.5 7.8 0.0078 14.4 0.9 1.8 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFX04103.1 - 1.3 7.0 18.3 0.11 10.5 3.6 2.5 2 1 0 2 2 2 0 Transmembrane secretion effector zf-CCCH PF00642.19 EFX04105.1 - 1.7e-05 24.3 0.9 1.7e-05 24.3 0.6 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Cwf_Cwc_15 PF04889.7 EFX04105.1 - 0.0025 17.5 10.5 0.0025 17.5 7.3 2.9 2 1 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein tRNA_int_endo PF01974.12 EFX04106.1 - 3.8e-14 52.2 0.0 7.5e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain GFA PF04828.9 EFX04107.1 - 1.1e-12 47.6 0.1 1.1e-12 47.6 0.1 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme HypD PF01924.11 EFX04107.1 - 0.047 12.4 0.5 0.063 12.0 0.3 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family PNTB PF02233.11 EFX04108.1 - 1.3e-157 525.3 29.9 1.3e-157 525.3 20.7 2.0 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_N PF05222.10 EFX04108.1 - 2.3e-48 163.6 0.0 7.3e-48 162.0 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 EFX04108.1 - 3.5e-47 160.1 0.3 6.3e-47 159.2 0.2 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF3814 PF12769.2 EFX04108.1 - 1e-29 102.5 3.4 1e-29 102.5 2.4 5.2 4 2 1 5 5 5 1 Domain of unknown function (DUF3814) Pyr_redox_2 PF07992.9 EFX04108.1 - 0.032 14.1 0.9 0.064 13.1 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_18 PF12847.2 EFX04108.1 - 0.034 14.7 0.0 0.11 13.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain 2-Hacid_dh_C PF02826.14 EFX04108.1 - 0.078 12.1 0.4 0.51 9.4 0.1 2.5 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_23 PF13489.1 EFX04108.1 - 0.32 10.6 0.0 0.57 9.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF1237 PF06824.6 EFX04109.1 - 1.3e-178 594.0 0.0 1.5e-178 593.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) Synaptobrevin PF00957.16 EFX04110.1 - 4e-15 55.1 1.6 6.2e-15 54.5 1.1 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 EFX04110.1 - 2.2e-14 52.7 0.0 4.6e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Terminase_2 PF03592.11 EFX04110.1 - 0.017 15.4 0.4 0.12 12.6 0.1 2.0 1 1 1 2 2 2 0 Terminase small subunit Tbf5 PF06331.7 EFX04110.1 - 0.041 13.6 0.3 0.08 12.7 0.2 1.4 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 Imm43 PF15602.1 EFX04110.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 43 WH2 PF02205.15 EFX04111.1 - 4.9e-08 32.3 1.3 2.3e-07 30.1 0.1 2.3 2 0 0 2 2 2 1 WH2 motif 2-Hacid_dh_C PF02826.14 EFX04112.1 - 1.2e-42 145.1 0.3 2.8e-28 98.2 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 EFX04112.1 - 0.0028 17.3 0.0 0.0053 16.4 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 EFX04112.1 - 0.0078 16.5 0.0 0.043 14.1 0.0 2.1 1 1 0 1 1 1 1 XdhC Rossmann domain NAD_binding_2 PF03446.10 EFX04112.1 - 0.01 15.6 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Oxidored_nitro PF00148.14 EFX04112.1 - 0.035 12.7 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase F420_oxidored PF03807.12 EFX04112.1 - 0.038 14.3 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Gp_dh_N PF00044.19 EFX04112.1 - 0.057 13.3 0.4 0.14 12.1 0.2 1.7 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 EFX04112.1 - 0.074 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding TrkA_N PF02254.13 EFX04112.1 - 0.09 12.7 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain IlvN PF07991.7 EFX04112.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain MFS_1 PF07690.11 EFX04113.1 - 8.6e-17 60.8 8.0 1.1e-16 60.5 5.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX04113.1 - 1.1e-16 60.4 7.2 2.1e-16 59.5 5.0 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 EFX04113.1 - 0.02 13.3 5.9 0.032 12.6 4.1 1.3 1 1 0 1 1 1 0 MFS/sugar transport protein Pol_alpha_B_N PF08418.5 EFX04114.1 - 2.3e-56 191.1 0.0 3.2e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 EFX04114.1 - 3.3e-39 134.3 0.0 4.6e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B TIMELESS PF04821.9 EFX04115.1 - 3.3e-88 295.4 0.0 3.3e-88 295.4 0.0 3.1 3 1 1 4 4 4 1 Timeless protein DUF1754 PF08555.5 EFX04115.1 - 0.061 13.9 11.9 0.17 12.4 8.2 1.7 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) GPCR_chapero_1 PF11904.3 EFX04115.1 - 0.11 11.6 5.8 0.18 10.9 4.0 1.3 1 0 0 1 1 1 0 GPCR-chaperone 7tm_1 PF00001.16 EFX04115.1 - 0.14 11.2 0.2 0.28 10.2 0.1 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) NOA36 PF06524.7 EFX04115.1 - 1.5 7.9 6.8 2.5 7.2 4.7 1.2 1 0 0 1 1 1 0 NOA36 protein NDUFB10 PF10249.4 EFX04116.1 - 0.0044 17.1 0.1 0.005 16.9 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.9 EFX04116.1 - 0.078 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 HWE histidine kinase DLH PF01738.13 EFX04117.1 - 5.8e-24 84.5 0.0 6.8e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFX04117.1 - 1.1e-05 25.1 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX04117.1 - 0.00026 20.2 0.0 0.0005 19.3 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family SUI1 PF01253.17 EFX04119.1 - 2e-28 97.9 1.3 2.6e-28 97.6 0.9 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.3 EFX04119.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Macoilin PF09726.4 EFX04120.1 - 0.38 8.9 5.1 0.42 8.8 3.5 1.0 1 0 0 1 1 1 0 Transmembrane protein Apc13p PF05839.6 EFX04121.1 - 2.6e-29 101.0 0.0 5.1e-29 100.0 0.0 1.5 1 0 0 1 1 1 1 Apc13p protein ADH_N PF08240.7 EFX04122.1 - 1.5e-22 79.3 0.3 3e-22 78.4 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX04122.1 - 7.1e-18 64.4 2.5 7.4e-18 64.3 0.8 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Shikimate_DH PF01488.15 EFX04122.1 - 0.09 12.8 0.2 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Methyltransf_18 PF12847.2 EFX04122.1 - 0.11 13.1 0.0 0.38 11.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain DUF1524 PF07510.6 EFX04123.1 - 2.2e-13 50.2 0.0 2.7e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) AAA_12 PF13087.1 EFX04124.1 - 1.5e-39 135.4 0.5 4.7e-39 133.8 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA PF00004.24 EFX04124.1 - 3.3e-38 130.8 0.0 4.8e-14 52.6 0.0 5.0 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 EFX04124.1 - 3e-23 82.6 29.8 5.5e-21 75.2 0.0 6.8 5 2 0 5 5 5 1 AAA domain AAA_19 PF13245.1 EFX04124.1 - 2.6e-13 49.5 10.5 0.014 15.1 0.0 5.6 5 0 0 5 5 5 4 Part of AAA domain AAA_5 PF07728.9 EFX04124.1 - 2.6e-11 43.3 0.4 0.004 16.8 0.0 3.9 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EFX04124.1 - 4.9e-10 39.6 13.4 0.0018 18.4 0.4 6.7 4 3 0 4 4 3 3 AAA domain AAA_33 PF13671.1 EFX04124.1 - 7e-08 32.4 0.4 0.21 11.4 0.0 4.4 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.16 EFX04124.1 - 5.8e-07 28.8 0.4 0.21 10.7 0.0 3.9 3 0 0 3 3 3 3 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 EFX04124.1 - 6.9e-07 30.1 26.2 0.024 15.4 0.0 6.2 5 0 0 5 5 4 3 AAA domain RNA_helicase PF00910.17 EFX04124.1 - 1.8e-05 24.8 0.1 3.4 7.8 0.0 3.9 3 0 0 3 3 3 2 RNA helicase Torsin PF06309.6 EFX04124.1 - 0.0001 22.1 0.0 5.7 6.8 0.0 3.8 3 0 0 3 3 3 1 Torsin AAA_24 PF13479.1 EFX04124.1 - 0.00014 21.4 3.8 0.81 9.2 0.1 4.0 3 0 0 3 3 3 2 AAA domain UvrD_C_2 PF13538.1 EFX04124.1 - 0.0046 17.0 0.0 0.025 14.7 0.0 2.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_18 PF13238.1 EFX04124.1 - 0.016 15.5 25.0 1.2 9.4 0.0 5.7 5 0 0 5 5 4 0 AAA domain AAA_16 PF13191.1 EFX04124.1 - 0.026 14.5 20.7 0.59 10.0 0.0 6.0 5 1 1 6 6 5 0 AAA ATPase domain MobB PF03205.9 EFX04124.1 - 0.029 14.0 0.8 9.8 5.8 0.0 3.6 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Mur_ligase_M PF08245.7 EFX04124.1 - 0.078 13.0 3.3 0.41 10.6 0.1 3.4 3 0 0 3 3 3 0 Mur ligase middle domain NTPase_1 PF03266.10 EFX04124.1 - 0.091 12.4 3.6 9.8 5.8 0.1 3.7 3 0 0 3 3 3 0 NTPase AAA_28 PF13521.1 EFX04124.1 - 1.1 9.2 14.6 4.3 7.2 0.0 4.9 4 0 0 4 4 3 0 AAA domain ADK PF00406.17 EFX04124.1 - 2.1 8.1 13.6 0.71 9.7 0.1 5.1 5 0 0 5 5 5 0 Adenylate kinase SRP54 PF00448.17 EFX04124.1 - 4 6.8 12.4 4.3 6.7 0.0 4.4 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain PAD_porph PF04371.10 EFX04125.1 - 0.024 13.6 0.0 0.028 13.4 0.0 1.1 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase Toxin_42 PF15522.1 EFX04125.1 - 0.074 12.2 0.0 0.075 12.2 0.0 1.0 1 0 0 1 1 1 0 Putative toxin 42 APH PF01636.18 EFX04125.1 - 0.083 12.5 0.0 0.092 12.4 0.0 1.0 1 0 0 1 1 1 0 Phosphotransferase enzyme family APH PF01636.18 EFX04126.1 - 9.6e-43 146.6 0.6 1.4e-42 146.1 0.4 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 EFX04126.1 - 0.00039 19.6 0.0 0.00057 19.1 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase 2-ph_phosp PF04029.9 EFX04127.1 - 0.084 11.8 1.0 0.1 11.5 0.7 1.1 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase PufQ PF05398.6 EFX04127.1 - 1.2 9.2 5.9 6.4 6.8 0.1 2.3 2 0 0 2 2 2 0 PufQ cytochrome subunit Pox_A28 PF04584.9 EFX04127.1 - 1.7 8.4 4.3 3.5 7.5 3.0 1.6 1 1 0 1 1 1 0 Poxvirus A28 family RgpF PF05045.7 EFX04128.1 - 0.13 10.8 0.0 0.21 10.0 0.0 1.5 1 1 0 1 1 1 0 Rhamnan synthesis protein F DUF202 PF02656.10 EFX04129.1 - 7.4e-25 86.9 2.3 7.4e-25 86.9 1.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF998 PF06197.8 EFX04129.1 - 0.0054 16.0 5.2 0.0079 15.5 3.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF998) SAM_2 PF07647.12 EFX04130.1 - 4.1e-06 26.5 0.0 1.1e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.24 EFX04130.1 - 0.002 18.3 0.0 0.48 10.6 0.0 2.5 2 0 0 2 2 2 2 PH domain Ste50p-SAM PF09235.5 EFX04130.1 - 0.24 11.4 0.0 0.44 10.6 0.0 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif CENP-B_dimeris PF09026.5 EFX04131.1 - 1 9.6 5.9 3.9 7.7 2.5 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3245 PF11595.3 EFX04131.1 - 1.6 8.9 6.0 0.32 11.2 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DUF2457 PF10446.4 EFX04131.1 - 5.5 5.5 9.1 27 3.3 5.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) adh_short PF00106.20 EFX04133.1 - 3.2e-20 72.7 0.9 2e-13 50.6 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04133.1 - 5.5e-11 42.6 0.0 4.1e-10 39.8 0.0 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFX04133.1 - 8.1e-10 38.9 0.1 1.3e-09 38.2 0.0 1.3 1 1 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EFX04133.1 - 2.2e-05 24.1 0.3 0.12 12.0 0.0 2.2 1 1 1 2 2 2 2 KR domain Epimerase PF01370.16 EFX04133.1 - 0.02 14.3 0.3 0.16 11.4 0.2 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EFX04133.1 - 0.026 13.4 0.2 0.7 8.7 0.0 2.2 2 0 0 2 2 2 0 RmlD substrate binding domain Eno-Rase_NADH_b PF12242.3 EFX04133.1 - 0.27 11.0 0.0 0.27 11.0 0.0 2.2 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PseudoU_synth_1 PF01416.15 EFX04135.1 - 5.6e-33 113.5 0.0 8.8e-22 77.5 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase OpcA_G6PD_assem PF10128.4 EFX04135.1 - 0.048 12.5 0.0 0.086 11.7 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit Siah-Interact_N PF09032.6 EFX04135.1 - 0.078 13.0 0.3 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Siah interacting protein, N terminal Ras PF00071.17 EFX04136.1 - 1.6e-37 128.4 0.0 2.2e-24 85.6 0.0 2.0 2 0 0 2 2 2 2 Ras family Miro PF08477.8 EFX04136.1 - 3.3e-11 43.7 0.0 6.8e-11 42.7 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 EFX04136.1 - 0.0061 16.5 0.0 0.0087 16.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase PRK PF00485.13 EFX04136.1 - 0.082 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family GTP_EFTU PF00009.22 EFX04136.1 - 0.14 11.5 0.0 2.9 7.2 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain 4HBT_3 PF13622.1 EFX04137.1 - 1.1e-41 143.2 0.0 1.6e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily RabGAP-TBC PF00566.13 EFX04138.1 - 5e-31 107.8 2.1 1.3e-26 93.3 0.0 2.6 3 0 0 3 3 3 2 Rab-GTPase-TBC domain dsDNA_bind PF01984.15 EFX04138.1 - 1.4 8.9 8.6 38 4.3 5.7 2.3 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Ribosomal_L38e PF01781.13 EFX04139.1 - 1.2e-32 111.4 2.5 1.5e-32 111.1 1.7 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Usp PF00582.21 EFX04140.1 - 6.2e-13 49.1 0.3 3.6e-06 27.2 0.0 2.8 2 0 0 2 2 2 2 Universal stress protein family Glyco_hydro_17 PF00332.13 EFX04143.1 - 0.021 13.8 2.6 0.051 12.6 1.8 1.8 1 1 0 1 1 1 0 Glycosyl hydrolases family 17 LCCL PF03815.14 EFX04144.1 - 2.2e-16 59.6 0.0 3.5e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 LCCL domain zf-H2C2_2 PF13465.1 EFX04145.1 - 0.0033 17.6 1.0 0.0033 17.6 0.7 3.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFX04145.1 - 1.3 9.5 28.5 0.052 13.8 1.2 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger SAP18 PF06487.7 EFX04146.1 - 3.6e-29 101.0 0.0 4.3e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) IU_nuc_hydro PF01156.14 EFX04147.1 - 1.7e-18 66.9 0.0 2.1e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PRELI PF04707.9 EFX04148.1 - 3e-21 75.6 0.1 1.2e-17 63.9 0.0 2.2 1 1 1 2 2 2 2 PRELI-like family Chitin_synth_2 PF03142.10 EFX04149.1 - 2e-251 835.0 1.6 6.7e-251 833.2 1.2 1.7 2 0 0 2 2 2 1 Chitin synthase Myosin_head PF00063.16 EFX04149.1 - 4.3e-158 527.4 0.0 1.4e-145 486.1 0.0 2.1 1 1 1 2 2 2 2 Myosin head (motor domain) Cyt-b5 PF00173.23 EFX04149.1 - 1.6e-20 72.6 0.4 8.8e-16 57.4 0.1 2.9 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.6 EFX04149.1 - 1e-17 63.6 0.7 1.2e-16 60.1 0.8 2.4 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.1 EFX04149.1 - 3.3e-16 59.5 5.0 4.3e-16 59.1 1.8 2.4 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFX04149.1 - 2.9e-14 53.4 0.0 8.4e-12 45.3 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EFX04149.1 - 0.0002 21.0 0.0 0.018 14.7 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF2592 PF10766.4 EFX04149.1 - 0.15 11.4 0.8 0.42 9.9 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2592) TFIID-18kDa PF02269.11 EFX04150.1 - 3e-19 68.5 0.0 5.1e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.8 EFX04150.1 - 0.0027 17.4 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.19 EFX04150.1 - 0.0031 17.6 0.0 0.0047 17.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.8 EFX04150.1 - 0.0058 16.8 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-S PF15630.1 EFX04150.1 - 0.022 14.9 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EFX04150.1 - 0.027 14.5 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2890 PF11081.3 EFX04151.1 - 0.22 11.5 1.9 0.76 9.8 1.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2890) Anoctamin PF04547.7 EFX04153.1 - 4.7e-120 401.2 1.8 6e-120 400.9 1.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel NACHT PF05729.7 EFX04154.1 - 1.1e-05 25.1 2.1 4.7e-05 23.1 0.1 2.7 2 1 0 2 2 2 1 NACHT domain DUF3427 PF11907.3 EFX04154.1 - 0.013 14.4 0.5 0.023 13.6 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3427) RNA_helicase PF00910.17 EFX04154.1 - 0.12 12.5 0.0 0.33 11.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase HisKA PF00512.20 EFX04154.1 - 0.41 10.6 2.3 32 4.6 0.0 3.5 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain TRAM_LAG1_CLN8 PF03798.11 EFX04155.1 - 1e-34 119.8 12.2 1.7e-34 119.1 8.4 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.6 EFX04155.1 - 2e-16 59.2 1.4 3.3e-16 58.5 0.0 2.1 2 0 0 2 2 2 1 TRAM1-like protein adh_short PF00106.20 EFX04156.1 - 1.3e-28 99.9 1.4 2.1e-28 99.3 0.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX04156.1 - 7e-13 48.6 0.3 1.1e-12 48.0 0.2 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFX04156.1 - 2.7e-08 33.8 0.0 3.6e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 EFX04156.1 - 0.0042 16.8 0.3 0.012 15.4 0.2 1.8 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Pyridoxal_deC PF00282.14 EFX04157.1 - 3.4e-65 219.9 0.0 7e-65 218.8 0.0 1.5 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 EFX04157.1 - 9.9e-05 21.6 0.0 0.00013 21.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EFX04157.1 - 0.00088 18.1 0.0 0.0016 17.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V MFS_1 PF07690.11 EFX04158.1 - 2.6e-28 98.7 22.2 2.6e-28 98.7 15.4 2.0 1 1 0 2 2 2 1 Major Facilitator Superfamily UPF0546 PF10639.4 EFX04158.1 - 0.032 14.0 1.6 9.5 6.0 0.5 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 Fungal_trans PF04082.13 EFX04159.1 - 1.2e-05 24.3 0.0 2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M19 PF01244.16 EFX04160.1 - 1.3e-96 323.3 0.0 1.6e-96 322.9 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Fungal_trans_2 PF11951.3 EFX04161.1 - 3.2e-76 256.4 0.0 4.2e-76 256.0 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04161.1 - 2e-05 24.4 10.0 2e-05 24.4 6.9 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med3 PF11593.3 EFX04161.1 - 0.051 12.8 9.0 0.035 13.3 4.8 1.7 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Tir_receptor_C PF07489.6 EFX04161.1 - 4.4 6.9 10.8 12 5.5 7.5 1.7 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.7 EFX04161.1 - 5.5 4.6 5.9 8 4.0 4.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIID-18kDa PF02269.11 EFX04162.1 - 5.1e-24 83.9 0.4 1.7e-23 82.2 0.0 2.0 3 0 0 3 3 3 1 Transcription initiation factor IID, 18kD subunit LCM PF04072.9 EFX04162.1 - 2.5e-19 69.5 0.0 1.7e-18 66.8 0.0 2.2 2 1 0 2 2 2 1 Leucine carboxyl methyltransferase Myc_N PF01056.13 EFX04162.1 - 0.089 11.9 0.8 0.16 11.0 0.6 1.3 1 0 0 1 1 1 0 Myc amino-terminal region Endosulfine PF04667.12 EFX04163.1 - 3.6e-21 74.9 0.0 7.6e-21 73.8 0.0 1.5 2 0 0 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region Cyclin_N PF00134.18 EFX04164.1 - 5.1e-10 39.0 0.1 8.5e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain TPR_11 PF13414.1 EFX04165.1 - 3.2e-43 145.2 36.7 6.1e-13 48.2 0.8 7.2 5 3 1 8 8 7 6 TPR repeat TPR_1 PF00515.23 EFX04165.1 - 1.5e-36 122.5 27.0 0.00026 20.4 0.1 11.4 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.12 EFX04165.1 - 9e-29 97.0 38.3 0.0023 17.7 0.1 11.7 12 0 0 12 12 11 10 Tetratricopeptide repeat TPR_12 PF13424.1 EFX04165.1 - 1.1e-20 73.3 26.9 5.3e-06 26.2 0.2 7.1 2 2 6 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.1 EFX04165.1 - 9.3e-19 67.5 19.7 0.00043 20.8 0.7 7.0 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 EFX04165.1 - 1e-13 50.2 9.7 0.57 10.5 0.1 8.8 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 EFX04165.1 - 2.4e-09 36.2 29.0 0.23 11.3 0.0 10.1 9 2 1 11 11 10 2 Tetratricopeptide repeat Apc3 PF12895.2 EFX04165.1 - 1.9e-08 34.2 18.9 0.0025 17.9 0.1 5.6 2 1 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EFX04165.1 - 1.5e-07 31.6 23.5 1e-05 25.7 0.2 6.5 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFX04165.1 - 7.5e-07 29.2 22.4 0.13 13.0 0.2 9.2 5 2 6 11 11 10 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFX04165.1 - 1.2e-06 27.8 24.2 0.17 11.7 0.1 9.4 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 EFX04165.1 - 4.9e-06 26.3 12.1 0.00047 19.9 0.2 5.3 5 2 3 8 8 8 3 Tetratricopeptide repeat MAS20 PF02064.10 EFX04165.1 - 0.0022 17.8 1.8 13 5.6 0.2 4.0 3 1 0 3 3 3 0 MAS20 protein import receptor SHNi-TPR PF10516.4 EFX04165.1 - 0.0048 16.1 2.0 1.5 8.0 0.0 3.8 3 0 0 3 3 3 1 SHNi-TPR TPR_10 PF13374.1 EFX04165.1 - 3.8 7.5 14.7 6.2 6.9 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.27 EFX04166.1 - 2.7e-25 87.2 0.9 1.8e-05 24.3 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat gpW PF02831.10 EFX04166.1 - 0.094 12.2 0.0 0.34 10.4 0.0 2.0 2 1 0 2 2 2 0 gpW zf-CCCH PF00642.19 EFX04167.1 - 0.017 14.8 4.8 0.027 14.1 3.3 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MFS_1 PF07690.11 EFX04168.1 - 6.8e-47 159.8 25.8 7.3e-43 146.6 12.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX04168.1 - 2.7e-13 49.3 12.2 2.7e-13 49.3 8.4 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFX04168.1 - 2.2e-08 32.7 4.4 3.5e-08 32.1 3.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 EFX04168.1 - 5.6e-06 24.7 4.0 1.1e-05 23.8 2.7 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_2 PF13347.1 EFX04168.1 - 0.00064 18.2 3.6 0.00064 18.2 2.5 3.3 3 1 1 4 4 4 2 MFS/sugar transport protein LRR_6 PF13516.1 EFX04169.1 - 5.1e-14 50.7 1.7 0.0024 17.7 0.0 6.7 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.2 EFX04169.1 - 9.8e-10 37.8 8.2 0.0021 17.6 0.0 5.3 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFX04169.1 - 2.2e-06 26.8 2.3 6.1 7.2 0.0 6.1 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 EFX04169.1 - 0.00063 19.5 2.7 85 4.0 0.0 5.6 5 0 0 5 5 5 0 Leucine rich repeat LETM1 PF07766.8 EFX04169.1 - 0.0038 16.2 0.0 0.0083 15.1 0.0 1.5 1 0 0 1 1 1 1 LETM1-like protein LRR_8 PF13855.1 EFX04169.1 - 0.011 15.4 10.1 17 5.2 0.0 4.9 3 2 0 3 3 3 0 Leucine rich repeat UPRTase PF14681.1 EFX04170.1 - 2e-54 183.9 0.0 2.3e-54 183.7 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EFX04170.1 - 9.8e-07 28.5 0.0 1.5e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Nop14 PF04147.7 EFX04171.1 - 0.022 12.6 8.4 0.033 12.1 5.8 1.2 1 0 0 1 1 1 0 Nop14-like family RNase_PH PF01138.16 EFX04173.1 - 2.9e-33 115.0 0.1 5e-33 114.2 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF4611 PF15387.1 EFX04173.1 - 0.00069 19.7 3.8 0.19 11.8 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4611) Pyr_redox_2 PF07992.9 EFX04174.1 - 3.7e-05 23.6 0.0 0.00011 22.1 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX04174.1 - 8e-05 22.7 0.2 0.0031 17.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PAXNEB PF05625.6 EFX04175.1 - 3.4e-71 240.0 0.0 5.2e-71 239.3 0.0 1.3 1 0 0 1 1 1 1 PAXNEB protein PAT1 PF09770.4 EFX04175.1 - 2.1 6.5 6.2 2.9 6.0 4.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDO_I PF05995.7 EFX04176.1 - 4.4e-37 126.9 0.0 5.5e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I DUF1637 PF07847.7 EFX04176.1 - 0.0029 16.9 0.4 0.0051 16.1 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1637) CDP-OH_P_transf PF01066.16 EFX04177.1 - 6.7e-18 64.8 2.8 6.7e-18 64.8 2.0 1.7 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Ribosomal_60s PF00428.14 EFX04177.1 - 6.3 7.2 8.1 3.7 7.9 3.9 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein NAP PF00956.13 EFX04178.1 - 6.6e-41 140.0 0.0 1.9e-40 138.5 0.0 1.6 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) BUD22 PF09073.5 EFX04178.1 - 0.29 10.1 19.2 0.39 9.7 13.3 1.1 1 0 0 1 1 1 0 BUD22 Daxx PF03344.10 EFX04178.1 - 2.1 6.6 14.3 3.3 6.0 9.9 1.2 1 0 0 1 1 1 0 Daxx Family Nop25 PF09805.4 EFX04178.1 - 5.4 7.0 12.5 13 5.8 8.6 1.7 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) IF3_C PF00707.17 EFX04180.1 - 3.3e-15 55.5 0.2 6.5e-15 54.6 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.1 EFX04180.1 - 0.0097 15.2 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial translation initiation factor SUZ PF12752.2 EFX04180.1 - 0.017 15.6 0.2 0.27 11.7 0.0 2.9 2 1 0 2 2 2 0 SUZ domain NPR3 PF03666.8 EFX04181.1 - 5.5e-60 203.1 0.0 6.5e-59 199.6 0.0 2.0 1 1 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 PARP PF00644.15 EFX04182.1 - 6.5e-12 45.3 0.0 1.2e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF830 PF05708.7 EFX04182.1 - 0.13 12.2 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Orthopoxvirus protein of unknown function (DUF830) Transp_cyt_pur PF02133.10 EFX04183.1 - 1.3e-85 287.5 46.2 1.7e-85 287.2 32.0 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Lysine_decarbox PF03641.9 EFX04184.1 - 8.9e-27 93.5 0.0 2e-26 92.3 0.0 1.6 1 1 0 1 1 1 1 Possible lysine decarboxylase GMC_oxred_N PF00732.14 EFX04185.1 - 1.7e-39 135.7 0.0 3.6e-39 134.6 0.0 1.5 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX04185.1 - 5.1e-23 81.9 0.0 1.1e-22 80.8 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EFX04185.1 - 5e-07 28.9 5.5 4.7e-06 25.7 2.6 2.7 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX04185.1 - 1.5e-05 24.9 1.0 4.3e-05 23.4 0.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX04185.1 - 3.4e-05 22.8 1.5 0.00021 20.2 0.9 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX04185.1 - 0.00015 21.7 0.1 0.00032 20.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFX04185.1 - 0.00016 20.9 0.2 0.00025 20.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EFX04185.1 - 0.00045 19.3 0.2 0.00099 18.2 0.1 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 EFX04185.1 - 0.0021 16.6 0.2 0.0066 14.9 0.2 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.2 EFX04185.1 - 0.062 12.3 1.1 0.091 11.8 0.8 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.13 EFX04185.1 - 0.16 11.5 0.1 0.27 10.8 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 EFX04185.1 - 0.24 11.8 1.6 0.5 10.8 1.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX04185.1 - 0.34 9.7 0.0 0.96 8.2 0.0 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A TBP PF00352.16 EFX04187.1 - 8.9e-69 226.8 0.1 9.2e-34 114.6 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EFX04187.1 - 0.0019 18.2 0.0 1.4 9.0 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Pollen_allerg_2 PF01620.11 EFX04187.1 - 0.027 14.8 0.5 0.039 14.2 0.3 1.3 1 0 0 1 1 1 0 Ribonuclease (pollen allergen) Pkinase PF00069.20 EFX04188.1 - 4.4e-71 239.0 0.0 1.6e-70 237.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04188.1 - 2.2e-30 105.5 0.0 7.7e-22 77.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFX04188.1 - 1.5e-06 27.4 0.0 0.14 11.1 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.9 EFX04188.1 - 0.028 13.5 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX04188.1 - 0.14 11.8 0.0 4 7.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DHquinase_I PF01487.10 EFX04189.1 - 1.6e-20 73.7 0.0 1.3e-19 70.7 0.0 2.0 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.17 EFX04189.1 - 1.2e-19 70.7 0.8 1.9e-19 70.0 0.1 1.7 2 0 0 2 2 2 1 Shikimate kinase Shikimate_DH PF01488.15 EFX04189.1 - 2.3e-12 47.1 0.0 5.4e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Shikimate_dh_N PF08501.6 EFX04189.1 - 4.1e-10 39.5 0.0 9.7e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain ThiF PF00899.16 EFX04189.1 - 0.055 13.2 0.1 0.21 11.4 0.0 1.9 2 0 0 2 2 2 0 ThiF family zf-U1 PF06220.7 EFX04190.1 - 1.2e-17 63.1 3.1 1.8e-17 62.5 2.1 1.3 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.3 EFX04190.1 - 0.2 11.8 1.6 0.42 10.8 1.1 1.5 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DNA_pol_A_exo1 PF01612.15 EFX04191.1 - 1.6e-13 50.4 0.0 2.4e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease vMSA PF00695.14 EFX04191.1 - 0.029 13.5 0.3 0.045 12.9 0.2 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Ribosomal_S7 PF00177.16 EFX04192.1 - 8.8e-22 77.2 0.0 1.4e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Milton PF12448.3 EFX04192.1 - 0.031 14.4 1.1 0.046 13.9 0.3 1.7 1 1 1 2 2 2 0 Kinesin associated protein Fungal_trans PF04082.13 EFX04193.1 - 4.8e-06 25.6 0.1 9.5e-06 24.6 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04193.1 - 1.1e-05 25.1 11.7 2.5e-05 24.1 8.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.17 EFX04194.1 - 3.2e-51 174.3 0.0 1.3e-50 172.3 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 UPF0052 PF01933.13 EFX04195.1 - 5.9e-37 127.6 0.0 1e-36 126.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 Btz PF09405.5 EFX04195.1 - 5.6e-26 91.1 0.5 5.6e-26 91.1 0.3 2.4 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding AMP-binding PF00501.23 EFX04197.1 - 7.5e-80 268.3 0.5 9.7e-80 267.9 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX04197.1 - 1.2e-11 45.4 2.7 2e-11 44.6 0.0 2.9 3 1 0 3 3 3 1 AMP-binding enzyme C-terminal domain DUF1777 PF08648.7 EFX04198.1 - 2.3e-23 82.8 117.2 3e-22 79.2 17.2 4.2 1 1 2 3 3 3 1 Protein of unknown function (DUF1777) AAA_22 PF13401.1 EFX04199.1 - 0.0012 19.0 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF4130 PF13566.1 EFX04199.1 - 0.0045 16.5 0.0 0.0085 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4130 NB-ARC PF00931.17 EFX04199.1 - 0.02 13.7 0.0 0.032 13.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PPR_3 PF13812.1 EFX04200.1 - 0.25 11.7 2.3 0.51 10.7 0.2 2.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain MFS_1 PF07690.11 EFX04201.1 - 3e-28 98.5 66.8 3.3e-25 88.5 43.2 4.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX04201.1 - 5.3e-05 21.6 19.4 0.00061 18.1 13.4 2.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFX04201.1 - 0.0012 17.5 44.5 0.032 12.8 13.9 4.6 2 2 2 4 4 4 2 Sugar (and other) transporter Adap_comp_sub PF00928.16 EFX04202.1 - 1.1e-15 57.4 0.0 1.7e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EFX04202.1 - 3e-08 33.5 0.0 4.9e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.6 EFX04202.1 - 0.015 15.4 0.2 0.033 14.3 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) RNase_PH PF01138.16 EFX04203.1 - 2.7e-26 92.4 0.1 8.9e-26 90.7 0.0 1.8 1 1 1 2 2 2 1 3' exoribonuclease family, domain 1 Mg_trans_NIPA PF05653.9 EFX04204.1 - 1e-83 280.8 15.5 1.2e-83 280.5 10.7 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 EFX04204.1 - 3.9e-05 23.8 2.0 3.9e-05 23.8 1.4 3.7 2 1 1 3 3 3 2 Multidrug resistance efflux transporter EamA PF00892.15 EFX04204.1 - 0.0033 17.4 7.9 0.0033 17.4 5.5 2.6 2 1 0 2 2 2 1 EamA-like transporter family DUF2937 PF11157.3 EFX04204.1 - 0.21 10.9 0.8 0.65 9.2 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Peptidase_MA_2 PF13485.1 EFX04206.1 - 8.2e-07 29.1 0.0 1.6e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 EFX04206.1 - 0.0035 17.2 0.0 0.028 14.3 0.0 2.2 1 1 0 1 1 1 1 M61 glycyl aminopeptidase PDZ PF00595.19 EFX04206.1 - 0.0083 16.2 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Apo-CIII PF05778.7 EFX04206.1 - 0.095 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) PDZ_2 PF13180.1 EFX04206.1 - 0.15 11.9 0.0 0.45 10.4 0.0 1.8 1 0 0 1 1 1 0 PDZ domain peroxidase PF00141.18 EFX04208.1 - 4.6e-24 85.1 0.1 7.2e-24 84.5 0.1 1.2 1 0 0 1 1 1 1 Peroxidase DUF3635 PF12330.3 EFX04209.1 - 4.7e-06 26.5 0.0 0.00016 21.6 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3635) APH PF01636.18 EFX04209.1 - 0.012 15.3 2.9 0.026 14.2 1.3 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF1266 PF06889.6 EFX04209.1 - 0.13 12.0 0.2 20 4.9 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1266) Not3 PF04065.10 EFX04210.1 - 8.7e-99 329.5 22.5 1.3e-98 328.9 15.6 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 EFX04210.1 - 4e-42 143.2 9.8 1e-41 141.9 6.8 1.8 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Syntaxin PF00804.20 EFX04210.1 - 0.0025 17.9 13.3 0.021 14.9 2.9 2.6 2 0 0 2 2 2 2 Syntaxin DUF2373 PF10180.4 EFX04210.1 - 0.022 14.3 2.5 0.046 13.2 1.7 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Snapin_Pallidin PF14712.1 EFX04210.1 - 0.047 14.0 5.5 0.32 11.3 0.1 2.5 2 0 0 2 2 2 0 Snapin/Pallidin Syntaxin_2 PF14523.1 EFX04210.1 - 0.077 13.0 6.4 0.094 12.7 2.0 2.4 2 0 0 2 2 2 0 Syntaxin-like protein DUF1192 PF06698.6 EFX04210.1 - 0.14 11.9 4.1 0.14 12.0 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Cep57_MT_bd PF06657.8 EFX04210.1 - 0.15 12.0 7.2 0.078 12.9 0.3 3.1 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Sec5 PF15469.1 EFX04210.1 - 0.23 11.1 7.1 0.036 13.8 1.2 2.2 2 0 0 2 2 2 0 Exocyst complex component Sec5 Nnf1 PF03980.9 EFX04210.1 - 0.62 10.0 8.0 0.3 11.0 2.0 2.7 1 1 1 2 2 2 0 Nnf1 YlqD PF11068.3 EFX04210.1 - 3.4 7.7 15.4 0.44 10.5 2.1 2.7 2 0 0 2 2 2 0 YlqD protein FlxA PF14282.1 EFX04210.1 - 7.3 6.6 14.4 3.1 7.8 1.2 3.4 2 1 1 3 3 3 0 FlxA-like protein CorA PF01544.13 EFX04211.1 - 4.2e-08 32.5 0.1 7.6e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Vps16_C PF04840.7 EFX04211.1 - 0.1 11.5 0.1 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Vps16, C-terminal region PolyA_pol PF01743.15 EFX04213.1 - 4.7e-27 94.7 0.1 1.4e-26 93.1 0.0 1.9 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 EFX04213.1 - 7.7e-09 34.9 0.0 1.9e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 EFX04213.1 - 0.12 12.1 0.1 0.25 11.1 0.0 1.6 2 0 0 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative HVSL PF09749.4 EFX04214.1 - 5.6e-62 208.8 0.0 6.9e-62 208.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein CMV_US PF08001.6 EFX04214.1 - 0.0081 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 CMV US Baculo_PEP_C PF04513.7 EFX04215.1 - 0.0024 17.6 5.8 0.074 12.8 1.7 2.3 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 EFX04215.1 - 0.0062 15.7 3.3 0.14 11.2 1.8 2.0 2 0 0 2 2 2 2 Reovirus sigma C capsid protein Borrelia_lipo_2 PF06238.6 EFX04215.1 - 0.14 12.1 0.9 0.27 11.3 0.3 1.7 2 0 0 2 2 2 0 Borrelia burgdorferi BBR25 lipoprotein Adaptin_N PF01602.15 EFX04216.1 - 1.5e-122 409.6 7.3 1.8e-122 409.3 5.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.11 EFX04216.1 - 4.8e-46 155.3 0.0 1.3e-45 153.9 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.15 EFX04216.1 - 7.9e-18 64.8 0.0 2e-17 63.5 0.0 1.7 2 0 0 2 2 2 1 Adaptin C-terminal domain Aminotran_4 PF01063.14 EFX04217.1 - 2.8e-20 72.7 0.0 5.1e-20 71.9 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class IV AIM24 PF01987.12 EFX04218.1 - 7.7e-52 175.8 0.0 9.5e-52 175.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF3123 PF11321.3 EFX04220.1 - 0.13 12.5 1.0 0.17 12.1 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Adaptin_binding PF10199.4 EFX04221.1 - 2.9e-13 50.2 0.1 6.4e-13 49.1 0.0 1.6 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 AlaDh_PNT_N PF05222.10 EFX04222.1 - 1.3e-28 99.7 0.0 1.8e-28 99.1 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 EFX04222.1 - 1.4e-15 57.2 0.1 1.9e-15 56.8 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Abhydrolase_6 PF12697.2 EFX04223.1 - 2.9e-40 138.5 5.8 3.4e-40 138.3 4.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX04223.1 - 5.3e-21 74.9 1.1 4.7e-20 71.8 0.8 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX04223.1 - 7.2e-16 58.4 0.0 1e-15 57.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.15 EFX04223.1 - 1.7e-09 38.2 0.0 2.4e-09 37.7 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.3 EFX04223.1 - 9.8e-07 28.5 0.0 2.9e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Putative lysophospholipase Esterase PF00756.15 EFX04223.1 - 2.2e-05 23.9 0.1 2.9e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.9 EFX04223.1 - 2.8e-05 22.7 0.0 3.5e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_2 PF02230.11 EFX04223.1 - 0.00073 19.0 0.0 0.038 13.4 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Ser_hydrolase PF06821.8 EFX04223.1 - 0.012 15.2 0.1 0.025 14.1 0.1 1.6 1 1 0 1 1 1 0 Serine hydrolase PGAP1 PF07819.8 EFX04223.1 - 0.017 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein DUF2305 PF10230.4 EFX04223.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Peptidase_S28 PF05577.7 EFX04223.1 - 0.043 12.4 0.0 0.064 11.8 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Abhydrolase_3 PF07859.8 EFX04223.1 - 0.048 13.2 0.5 0.076 12.5 0.3 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S37 PF05576.6 EFX04223.1 - 0.063 11.7 0.0 0.095 11.1 0.0 1.2 1 0 0 1 1 1 0 PS-10 peptidase S37 FSH1 PF03959.8 EFX04223.1 - 0.071 12.5 0.0 0.34 10.3 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Pkinase PF00069.20 EFX04224.1 - 3.1e-72 242.8 0.0 3.8e-72 242.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04224.1 - 1.1e-31 109.9 0.0 1.4e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EFX04224.1 - 3.9e-06 26.0 0.0 1.3e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EFX04224.1 - 0.00032 20.4 0.1 0.0012 18.6 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EFX04224.1 - 0.00087 18.3 0.0 0.023 13.6 0.0 2.1 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.17 EFX04224.1 - 0.021 14.1 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family ApoO PF09769.4 EFX04225.1 - 2.6e-43 147.4 2.3 3.5e-42 143.7 0.0 2.4 3 0 0 3 3 3 2 Apolipoprotein O Gag_spuma PF03276.9 EFX04225.1 - 8.9 4.5 8.3 11 4.2 5.7 1.1 1 0 0 1 1 1 0 Spumavirus gag protein p450 PF00067.17 EFX04226.1 - 6.1e-63 212.9 0.0 7.7e-63 212.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.19 EFX04227.1 - 2.1e-94 316.6 19.1 2.5e-94 316.4 13.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04227.1 - 1.3e-33 116.2 23.7 1.3e-33 116.2 16.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Abhydrolase_6 PF12697.2 EFX04228.1 - 7e-28 98.0 0.2 1.5e-27 96.9 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX04228.1 - 1.8e-13 50.5 0.0 5.7e-09 35.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX04228.1 - 8.3e-11 41.8 0.0 5.5e-10 39.1 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EFX04228.1 - 0.0012 18.6 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 EFX04228.1 - 0.0037 16.5 0.0 0.019 14.2 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_4 PF08386.5 EFX04228.1 - 0.049 13.5 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein GTP_EFTU PF00009.22 EFX04229.1 - 3.1e-38 131.0 0.9 1.6e-37 128.7 0.6 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EFX04229.1 - 1.5e-22 79.5 0.1 3e-22 78.5 0.1 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EFX04229.1 - 3.9e-09 36.4 1.0 1.4e-05 25.0 0.1 2.7 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX04229.1 - 1.7e-06 27.9 0.0 3.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.10 EFX04229.1 - 4.9e-05 22.8 0.0 9.8e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region FeoB_N PF02421.13 EFX04229.1 - 0.00014 21.2 0.0 0.00025 20.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 EFX04229.1 - 0.00025 21.5 0.0 0.00053 20.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 EFX04229.1 - 0.00037 19.9 0.0 0.001 18.5 0.0 1.7 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.16 EFX04229.1 - 0.00086 18.5 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EFX04229.1 - 0.0063 15.7 0.1 0.017 14.3 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 EFX04229.1 - 1.9 8.2 4.6 25 4.6 0.0 3.6 3 1 1 4 4 4 0 Dynamin family Sugar_tr PF00083.19 EFX04231.1 - 1.2e-120 403.1 18.2 2.2e-120 402.2 12.6 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04231.1 - 4.9e-28 97.8 36.9 2.6e-21 75.7 8.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex2_Pex12 PF04757.9 EFX04232.1 - 6.8e-54 182.7 1.9 9.3e-54 182.2 1.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.1 EFX04232.1 - 8.8e-05 22.2 2.2 0.00015 21.6 1.5 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EFX04232.1 - 0.00015 21.6 3.0 0.00026 20.9 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX04232.1 - 0.0042 16.8 1.8 0.0065 16.2 1.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFX04232.1 - 0.18 11.4 2.9 0.31 10.7 2.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ras PF00071.17 EFX04233.1 - 1.6e-16 60.0 0.0 3.3e-13 49.3 0.0 2.0 2 0 0 2 2 2 2 Ras family Miro PF08477.8 EFX04233.1 - 9e-08 32.6 0.0 1.3e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX04233.1 - 0.0036 16.5 0.0 0.37 10.0 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family NACHT PF05729.7 EFX04233.1 - 0.011 15.4 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.1 EFX04233.1 - 0.024 14.1 0.1 0.038 13.5 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 EFX04233.1 - 0.041 13.8 0.1 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.15 EFX04233.1 - 0.081 11.5 0.1 0.12 11.0 0.1 1.1 1 0 0 1 1 1 0 G-protein alpha subunit DUF258 PF03193.11 EFX04233.1 - 0.11 11.6 0.1 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 EFX04233.1 - 0.13 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain GFA PF04828.9 EFX04235.1 - 1.2e-20 73.2 0.1 2.3e-20 72.3 0.1 1.5 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Auto_anti-p27 PF06677.7 EFX04235.1 - 0.0018 17.9 0.0 0.0044 16.7 0.0 1.6 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) FAD_binding_4 PF01565.18 EFX04236.1 - 2e-28 98.5 0.1 3.2e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.14 EFX04236.1 - 0.0005 19.4 0.1 0.0023 17.3 0.0 2.0 1 1 1 2 2 2 1 FAD linked oxidases, C-terminal domain cNMP_binding PF00027.24 EFX04237.1 - 3.5e-34 116.4 0.0 1.4e-17 63.2 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain FMN_red PF03358.10 EFX04237.1 - 1.4e-27 96.1 0.1 3.2e-27 94.9 0.1 1.6 1 0 0 1 1 1 1 NADPH-dependent FMN reductase LRR_6 PF13516.1 EFX04237.1 - 2.5e-12 45.4 1.2 0.071 13.2 0.0 7.9 8 0 0 8 8 8 2 Leucine Rich repeat Flavodoxin_2 PF02525.12 EFX04237.1 - 7e-07 28.9 0.0 1.5e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin-like fold F-box-like PF12937.2 EFX04237.1 - 1.2e-05 24.9 0.7 4.1e-05 23.2 0.5 2.0 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 EFX04237.1 - 0.0001 21.9 0.4 0.62 9.8 0.1 3.9 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 EFX04237.1 - 0.00047 19.8 5.7 21 5.6 0.0 7.0 5 2 1 6 6 6 0 Leucine Rich Repeat F-box PF00646.28 EFX04237.1 - 0.00091 18.8 3.0 0.00098 18.7 0.4 2.4 2 0 0 2 2 2 1 F-box domain DUF605 PF04652.11 EFX04237.1 - 4.4 6.5 16.9 0.75 9.1 7.9 2.1 2 0 0 2 2 2 0 Vta1 like WD40 PF00400.27 EFX04238.1 - 1.4e-30 104.0 7.8 2.9e-07 30.0 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat NLE PF08154.7 EFX04238.1 - 7.3e-18 64.3 0.0 1.2e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nucleoporin_N PF08801.6 EFX04238.1 - 0.045 12.4 0.0 7.4 5.1 0.0 2.3 2 0 0 2 2 2 0 Nup133 N terminal like Asn_synthase PF00733.16 EFX04239.1 - 1.1e-66 224.9 0.0 1.5e-66 224.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EFX04239.1 - 9.8e-37 125.4 0.0 1.5e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EFX04239.1 - 1.9e-28 99.0 0.0 3.8e-28 98.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 EFX04239.1 - 2.4e-06 26.9 0.0 4.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.12 EFX04239.1 - 0.0031 16.4 0.0 0.011 14.5 0.0 1.7 2 0 0 2 2 2 1 NAD synthase GATase_2 PF00310.16 EFX04239.1 - 0.0064 15.2 0.0 0.13 10.9 0.0 2.4 1 1 2 3 3 3 1 Glutamine amidotransferases class-II Fungal_trans PF04082.13 EFX04240.1 - 8e-36 123.2 0.0 2.3e-35 121.7 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04240.1 - 0.00059 19.6 1.5 0.001 18.9 1.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Catalase PF00199.14 EFX04241.1 - 1e-57 195.6 0.2 1.3e-57 195.2 0.2 1.0 1 0 0 1 1 1 1 Catalase RNA_pol_A_bac PF01000.21 EFX04242.1 - 4.7e-27 94.3 0.0 9.4e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EFX04242.1 - 3.8e-13 48.3 0.0 5.2e-13 47.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Abhydrolase_4 PF08386.5 EFX04243.1 - 8.9e-16 57.6 0.0 2.3e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 EFX04243.1 - 1.8e-10 40.7 0.7 1.2e-09 38.0 0.5 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX04243.1 - 3.9e-09 36.7 15.4 2.2e-07 30.9 10.7 2.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX04243.1 - 0.00064 19.4 0.0 0.0033 17.1 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Pkinase PF00069.20 EFX04244.1 - 6.3e-27 94.3 0.0 1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04244.1 - 3.5e-15 55.7 0.0 5.2e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2-set PF05790.10 EFX04244.1 - 0.088 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin C2-set domain Cupin_2 PF07883.6 EFX04245.1 - 1.4e-08 34.0 0.1 0.00014 21.2 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_1 PF00190.17 EFX04245.1 - 1.1e-05 24.9 0.0 1.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Cupin NAD_binding_8 PF13450.1 EFX04245.1 - 1.4e-05 25.0 0.1 3.5e-05 23.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFX04245.1 - 0.00012 20.6 0.3 0.00056 18.5 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.19 EFX04245.1 - 0.0003 19.8 0.2 0.016 14.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX04245.1 - 0.0015 18.4 0.0 0.0071 16.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX04245.1 - 0.004 16.0 0.3 0.0072 15.2 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Cupin_3 PF05899.7 EFX04245.1 - 0.02 14.2 0.0 0.053 12.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF861) GMC_oxred_N PF00732.14 EFX04245.1 - 0.036 13.2 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Trp_halogenase PF04820.9 EFX04245.1 - 0.047 12.3 0.1 0.068 11.7 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Lycopene_cycl PF05834.7 EFX04245.1 - 0.055 12.3 0.1 0.31 9.9 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.22 EFX04245.1 - 0.06 13.7 0.0 0.41 11.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFX04245.1 - 0.11 11.5 0.2 0.75 8.8 0.1 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.12 EFX04245.1 - 0.12 11.4 0.2 0.2 10.7 0.1 1.2 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.17 EFX04245.1 - 0.16 10.7 0.2 0.22 10.3 0.2 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Arf PF00025.16 EFX04246.1 - 4.7e-40 136.6 0.1 1.1e-25 89.8 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.15 EFX04246.1 - 2.3e-12 46.3 0.0 6.3e-08 31.7 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 EFX04246.1 - 5e-08 32.4 0.0 0.0034 16.8 0.0 2.2 2 0 0 2 2 2 2 Ras family Gtr1_RagA PF04670.7 EFX04246.1 - 1.1e-07 31.2 0.0 1.2e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EFX04246.1 - 2.5e-06 26.8 0.0 0.00014 21.1 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Miro PF08477.8 EFX04246.1 - 6e-05 23.5 0.0 0.00027 21.4 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 EFX04246.1 - 8.6e-05 22.0 0.0 0.00034 20.1 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EFX04246.1 - 0.016 15.1 0.0 0.042 13.7 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rif1_N PF12231.3 EFX04247.1 - 1.2e-124 416.0 0.0 1.9e-124 415.4 0.0 1.3 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Serglycin PF04360.7 EFX04247.1 - 2 8.1 6.9 0.56 9.9 0.1 2.9 3 0 0 3 3 3 0 Serglycin Pkinase PF00069.20 EFX04248.1 - 2.5e-22 79.2 0.0 2e-12 46.8 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04248.1 - 1.4e-17 63.6 0.0 3.7e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFX04248.1 - 0.13 11.2 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RCC1 PF00415.13 EFX04249.1 - 6.3e-21 74.3 1.0 1.6e-06 28.2 0.0 5.0 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 EFX04249.1 - 2.1e-12 46.9 0.0 5.2e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.1 EFX04249.1 - 5.1e-09 35.5 11.0 6e-08 32.0 1.3 3.8 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.1 EFX04249.1 - 1.8e-08 34.6 0.2 5.1e-08 33.2 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX04249.1 - 7.7e-05 22.5 0.1 0.52 10.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 EFX04249.1 - 0.0012 19.1 0.1 0.0026 18.0 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFX04249.1 - 0.057 13.2 0.0 0.18 11.6 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeat GRP PF07172.6 EFX04249.1 - 0.25 11.8 37.6 1.6 9.2 5.9 4.2 4 0 0 4 4 4 0 Glycine rich protein family Sulfate_transp PF00916.15 EFX04251.1 - 0.95 8.4 16.4 0.084 11.8 6.3 2.5 2 1 0 2 2 2 0 Sulfate transporter family AAA PF00004.24 EFX04252.1 - 1.2e-11 44.9 0.2 1.3e-10 41.5 0.2 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF1601 PF07671.6 EFX04252.1 - 0.0038 16.8 0.1 1.4 8.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1601) DUF2360 PF10152.4 EFX04252.1 - 0.0098 16.1 3.0 0.027 14.7 2.1 1.7 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein (DUF2360) AAA_22 PF13401.1 EFX04252.1 - 0.049 13.7 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX04252.1 - 0.067 13.1 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 EFX04252.1 - 0.082 12.6 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Striatin PF08232.7 EFX04252.1 - 2.2 8.5 11.3 3.4 7.9 3.7 2.9 3 0 0 3 3 3 0 Striatin family Methyltransf_2 PF00891.13 EFX04254.1 - 1.9e-29 102.5 0.0 4.3e-29 101.4 0.0 1.6 1 0 0 1 1 1 1 O-methyltransferase Trp_halogenase PF04820.9 EFX04254.1 - 5.2e-27 94.5 0.1 6.2e-13 48.1 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.14 EFX04254.1 - 4.4e-13 49.0 0.0 8.4e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX04254.1 - 0.0007 19.5 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX04254.1 - 0.0026 17.7 1.4 0.011 15.8 0.2 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX04254.1 - 0.0048 15.8 0.8 0.12 11.2 0.3 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX04254.1 - 0.017 14.0 0.3 0.031 13.1 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.17 EFX04254.1 - 0.032 13.1 0.1 0.052 12.4 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX04254.1 - 0.033 13.2 1.8 0.06 12.4 1.3 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX04254.1 - 0.059 11.8 0.2 0.099 11.0 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Pkinase PF00069.20 EFX04255.1 - 1.2e-41 142.5 0.0 9.4e-41 139.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04255.1 - 4.8e-14 52.0 0.0 3.6e-12 45.9 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.18 EFX04255.1 - 6.8e-06 25.9 0.1 0.01 15.5 0.0 3.4 2 2 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 EFX04255.1 - 0.0013 17.7 0.0 0.003 16.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EFX04255.1 - 0.056 12.5 0.1 0.64 9.0 0.1 2.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Actino_peptide PF14408.1 EFX04255.1 - 0.081 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Ribosomally synthesized peptide in actinomycetes Peptidase_S8 PF00082.17 EFX04256.1 - 1.2e-18 67.3 1.0 2e-18 66.5 0.7 1.3 1 0 0 1 1 1 1 Subtilase family Ank_2 PF12796.2 EFX04256.1 - 0.0097 16.2 0.0 0.075 13.3 0.0 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 EFX04256.1 - 0.012 15.3 0.1 3.5 7.5 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat NAD_binding_10 PF13460.1 EFX04257.1 - 1e-16 61.4 2.3 1.9e-16 60.5 1.6 1.4 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFX04257.1 - 0.00063 19.2 0.1 0.0014 18.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Apc4 PF12896.2 EFX04258.1 - 9.7e-47 158.9 0.1 1.6e-46 158.3 0.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 WD40 PF00400.27 EFX04258.1 - 0.00096 18.9 0.0 0.11 12.4 0.0 3.5 4 0 0 4 4 4 1 WD domain, G-beta repeat Methyltransf_24 PF13578.1 EFX04259.1 - 9.9e-15 55.2 0.0 1.8e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04259.1 - 0.0051 17.3 0.1 0.012 16.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 EFX04259.1 - 0.0083 15.1 0.1 0.028 13.4 0.0 1.9 1 1 0 1 1 1 1 O-methyltransferase CmcI PF04989.7 EFX04259.1 - 0.095 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Cephalosporin hydroxylase Malic_M PF03949.10 EFX04262.1 - 3.9e-73 246.1 0.0 5e-73 245.7 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EFX04262.1 - 7e-61 204.9 0.0 1e-60 204.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Fer2_3 PF13085.1 EFX04263.1 - 1.1e-30 105.6 0.0 2.3e-30 104.6 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.1 EFX04263.1 - 4.8e-09 36.1 3.7 4.8e-09 36.1 2.6 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.1 EFX04263.1 - 1.3e-08 35.0 5.7 1.3e-08 35.0 4.0 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 EFX04263.1 - 4e-05 23.9 0.8 4e-05 23.9 0.6 2.5 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EFX04263.1 - 0.00027 20.6 2.4 0.00027 20.6 1.7 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 EFX04263.1 - 0.00028 20.5 2.0 0.0032 17.1 0.3 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.1 EFX04263.1 - 0.00029 21.0 4.6 0.034 14.4 0.5 3.0 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.2 EFX04263.1 - 0.0095 16.3 3.6 0.0095 16.3 2.5 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.1 EFX04263.1 - 0.7 10.5 4.9 0.92 10.1 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S single cluster domain RNase_PH PF01138.16 EFX04264.1 - 1.2e-21 77.3 0.0 2.2e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EFX04264.1 - 6.2e-07 29.2 0.0 1.8e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 MutS_IV PF05190.13 EFX04265.1 - 0.13 12.4 0.1 4.2 7.6 0.1 2.4 2 0 0 2 2 2 0 MutS family domain IV IlvN PF07991.7 EFX04266.1 - 8.9e-46 155.2 0.0 1.4e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvC PF01450.14 EFX04266.1 - 3.8e-45 153.3 0.0 5.5e-45 152.8 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.12 EFX04266.1 - 0.046 14.1 0.7 0.13 12.6 0.0 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent KH_1 PF00013.24 EFX04267.1 - 1.4e-40 136.7 6.9 1.5e-16 59.7 0.5 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EFX04267.1 - 3.5e-31 106.3 12.8 1.3e-11 43.8 2.3 3.5 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EFX04267.1 - 1.1e-12 47.3 5.8 0.002 17.6 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EFX04267.1 - 2.5e-05 23.8 2.2 0.67 9.6 0.0 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.1 EFX04267.1 - 0.00084 19.0 7.0 0.84 9.4 0.2 3.4 3 0 0 3 3 3 2 NusA-like KH domain MR_MLE_N PF02746.11 EFX04267.1 - 0.11 12.5 0.1 7 6.6 0.0 2.4 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain ketoacyl-synt PF00109.21 EFX04268.1 - 2.4e-65 220.5 3.0 1.8e-63 214.4 0.5 3.0 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX04268.1 - 3e-43 148.3 0.0 5.4e-43 147.5 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 EFX04268.1 - 6e-32 109.9 1.9 1.2e-31 108.9 0.3 2.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFX04268.1 - 2.9e-14 53.0 0.2 7.3e-14 51.7 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 EFX04268.1 - 1.8e-06 27.1 0.1 3.3e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 EFX04268.1 - 0.051 13.2 3.7 0.14 11.8 2.5 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III AA_permease_2 PF13520.1 EFX04269.1 - 3e-61 207.2 51.8 3.7e-61 206.9 35.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX04269.1 - 7.2e-20 70.7 44.9 9.7e-20 70.3 31.1 1.1 1 0 0 1 1 1 1 Amino acid permease Arginase PF00491.16 EFX04272.1 - 1.4e-88 296.8 0.0 1.8e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 EFX04272.1 - 0.097 12.8 0.1 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 UPF0489 domain Metallophos PF00149.23 EFX04273.1 - 7.7e-12 45.0 7.3 1.4e-10 40.9 5.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EFX04273.1 - 0.0016 18.2 0.0 0.0031 17.3 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CoaE PF01121.15 EFX04274.1 - 3e-41 140.8 0.0 5.2e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 EFX04274.1 - 0.00081 20.2 0.0 0.0016 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX04274.1 - 0.14 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Hemerythrin PF01814.18 EFX04275.1 - 2.6e-09 37.3 0.2 3.4e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Exo_endo_phos PF03372.18 EFX04276.1 - 3e-28 99.4 0.3 6.3e-28 98.3 0.2 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MRF_C1 PF13887.1 EFX04276.1 - 0.2 10.6 0.3 1 8.4 0.0 2.1 2 0 0 2 2 2 0 Myelin gene regulatory factor -C-terminal domain 1 CMD PF02627.15 EFX04277.1 - 4.9e-09 35.9 2.0 1.2e-07 31.4 0.4 2.4 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family Sybindin PF04099.7 EFX04278.1 - 1.8e-49 167.1 0.0 2.5e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 EFX04278.1 - 7.1e-08 32.3 0.1 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region MFS_1 PF07690.11 EFX04279.1 - 1.7e-17 63.1 17.1 2.3e-17 62.7 11.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CBM_2 PF00553.14 EFX04279.1 - 0.051 13.6 0.6 0.11 12.5 0.4 1.5 1 0 0 1 1 1 0 Cellulose binding domain DUF308 PF03729.8 EFX04279.1 - 0.054 13.4 3.9 0.13 12.3 1.9 2.3 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) IU_nuc_hydro PF01156.14 EFX04280.1 - 8.9e-51 172.9 0.1 1.4e-40 139.4 0.0 2.2 2 0 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase Transketolase_C PF02780.15 EFX04280.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain Colicin_M PF14859.1 EFX04280.1 - 0.14 11.0 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Colicin M CLTH PF10607.4 EFX04282.1 - 4e-34 117.3 0.0 5.7e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.23 EFX04282.1 - 6e-24 84.5 0.2 1e-23 83.7 0.2 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.6 EFX04282.1 - 5.5e-06 25.9 0.2 1.6e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 LisH DUF2428 PF10350.4 EFX04283.1 - 1.5e-58 197.8 0.7 3.3e-58 196.7 0.5 1.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 EFX04283.1 - 0.0019 18.1 20.4 2.6 8.3 0.0 7.3 6 0 0 6 6 6 3 HEAT repeat Transp_cyt_pur PF02133.10 EFX04285.1 - 1.2e-90 304.2 36.8 1.5e-68 231.4 15.2 2.0 2 0 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin Aconitase PF00330.15 EFX04286.1 - 2.4e-179 596.6 0.0 2.9e-179 596.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFX04286.1 - 2e-40 137.9 0.0 3.5e-40 137.1 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Fungal_trans_2 PF11951.3 EFX04287.1 - 8.1e-31 106.9 0.0 1e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04287.1 - 4.7e-07 29.5 10.6 1.1e-06 28.4 7.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF775 PF05603.7 EFX04288.1 - 1e-43 149.2 0.0 1.2e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Ufm1 PF03671.9 EFX04288.1 - 0.37 10.5 2.3 0.41 10.4 0.7 1.8 2 0 0 2 2 2 0 Ubiquitin fold modifier 1 protein PhyH PF05721.8 EFX04289.1 - 1.8e-07 31.4 0.0 4e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) ABC_tran PF00005.22 EFX04290.1 - 8.6e-47 158.8 0.1 3.3e-23 82.4 0.0 3.5 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFX04290.1 - 2.1e-16 59.8 0.8 0.00011 21.5 0.1 4.2 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX04290.1 - 1.1e-15 58.3 1.1 0.00079 19.4 0.0 4.4 3 1 0 4 4 4 3 AAA domain AAA_29 PF13555.1 EFX04290.1 - 3.9e-10 39.0 0.0 0.0012 18.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 EFX04290.1 - 3.2e-08 34.4 0.0 0.0031 18.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EFX04290.1 - 9.4e-08 32.2 0.0 0.00091 19.3 0.0 3.5 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.1 EFX04290.1 - 1e-07 32.0 0.0 0.007 16.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFX04290.1 - 1.1e-07 31.1 0.0 0.00098 18.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFX04290.1 - 6.9e-07 28.9 0.1 0.067 12.6 0.0 3.8 4 0 0 4 4 4 2 AAA-like domain AAA_23 PF13476.1 EFX04290.1 - 1.2e-06 29.0 8.3 0.0056 17.0 0.0 3.2 4 1 0 4 4 2 2 AAA domain AAA_15 PF13175.1 EFX04290.1 - 1.4e-06 27.6 0.7 0.046 12.7 0.0 4.0 4 1 0 4 4 4 1 AAA ATPase domain AAA_33 PF13671.1 EFX04290.1 - 1.8e-06 27.8 0.0 0.11 12.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain ArgK PF03308.11 EFX04290.1 - 3.1e-06 26.1 0.2 0.065 12.0 0.0 2.9 3 0 0 3 3 3 2 ArgK protein MMR_HSR1 PF01926.18 EFX04290.1 - 4.2e-06 26.6 0.0 0.031 14.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.1 EFX04290.1 - 6.5e-06 26.4 0.3 0.33 11.2 0.0 3.5 3 0 0 3 3 3 2 AAA domain Dynamin_N PF00350.18 EFX04290.1 - 9.6e-06 25.5 0.0 0.0033 17.2 0.0 2.7 2 0 0 2 2 2 1 Dynamin family SbcCD_C PF13558.1 EFX04290.1 - 1.1e-05 25.1 0.0 0.027 14.4 0.0 3.2 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Miro PF08477.8 EFX04290.1 - 1.3e-05 25.6 0.1 0.057 13.9 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA PF00004.24 EFX04290.1 - 2.1e-05 24.7 0.0 0.24 11.5 0.0 3.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ParcG PF10274.4 EFX04290.1 - 4e-05 23.6 0.4 0.3 10.9 0.0 3.0 1 1 2 3 3 3 2 Parkin co-regulated protein MobB PF03205.9 EFX04290.1 - 7.4e-05 22.4 0.5 0.48 10.1 0.0 3.1 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 EFX04290.1 - 7.6e-05 22.4 0.0 0.082 12.5 0.0 2.7 2 0 0 2 2 2 1 NACHT domain PduV-EutP PF10662.4 EFX04290.1 - 7.9e-05 22.1 0.0 0.081 12.4 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 EFX04290.1 - 8.3e-05 22.7 0.0 0.71 10.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_16 PF13191.1 EFX04290.1 - 0.0001 22.3 2.7 0.86 9.5 0.0 4.7 5 0 0 5 5 5 1 AAA ATPase domain DUF87 PF01935.12 EFX04290.1 - 0.0002 21.2 0.1 0.11 12.2 0.0 3.2 3 0 0 3 3 2 1 Domain of unknown function DUF87 AAA_14 PF13173.1 EFX04290.1 - 0.00026 20.8 0.0 1.3 8.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain Arch_ATPase PF01637.13 EFX04290.1 - 0.00044 20.0 0.0 0.34 10.5 0.0 2.9 2 0 0 2 2 2 1 Archaeal ATPase AAA_30 PF13604.1 EFX04290.1 - 0.0024 17.4 0.2 6.5 6.2 0.0 3.8 5 0 0 5 5 4 0 AAA domain cobW PF02492.14 EFX04290.1 - 0.0027 17.1 0.0 2.2 7.7 0.0 2.9 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 EFX04290.1 - 0.0035 16.7 0.0 2.3 7.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.15 EFX04290.1 - 0.0069 15.1 0.2 1.1 7.8 0.0 2.4 2 0 0 2 2 2 1 G-protein alpha subunit FtsK_SpoIIIE PF01580.13 EFX04290.1 - 0.0076 15.7 0.1 1 8.7 0.0 2.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family ATP_bind_1 PF03029.12 EFX04290.1 - 0.0076 15.8 0.1 5.5 6.4 0.0 3.0 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein MutS_V PF00488.16 EFX04290.1 - 0.011 15.1 0.1 0.74 9.1 0.0 2.4 2 0 0 2 2 2 0 MutS domain V PRK PF00485.13 EFX04290.1 - 0.015 14.8 0.0 0.91 9.0 0.0 2.8 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family IstB_IS21 PF01695.12 EFX04290.1 - 0.016 14.6 0.0 6 6.2 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Septin PF00735.13 EFX04290.1 - 0.018 14.0 0.4 2 7.3 0.0 2.7 3 0 0 3 3 2 0 Septin T2SE PF00437.15 EFX04290.1 - 0.02 13.8 0.1 2.6 6.8 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein ATP-synt_ab PF00006.20 EFX04290.1 - 0.022 14.2 0.1 4.3 6.7 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain 2OG-FeII_Oxy_4 PF13661.1 EFX04290.1 - 0.024 14.2 0.0 0.077 12.6 0.1 1.8 2 0 0 2 2 1 0 2OG-Fe(II) oxygenase superfamily DUF815 PF05673.8 EFX04290.1 - 0.025 13.5 0.0 10 4.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF815) NB-ARC PF00931.17 EFX04290.1 - 0.027 13.3 0.1 0.3 9.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.10 EFX04290.1 - 0.041 12.5 0.0 4.7 5.7 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Mg_chelatase PF01078.16 EFX04290.1 - 0.069 12.2 0.0 6 5.9 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI HEAT_2 PF13646.1 EFX04290.1 - 0.18 12.0 5.8 7.5 6.9 4.7 2.7 1 1 1 2 2 2 0 HEAT repeats AAA_13 PF13166.1 EFX04290.1 - 0.31 9.4 9.0 1.1 7.6 0.0 3.3 5 0 0 5 5 4 0 AAA domain LSM PF01423.17 EFX04291.1 - 2.6e-16 58.9 0.9 4.5e-16 58.1 0.6 1.4 1 0 0 1 1 1 1 LSM domain YbbR PF07949.7 EFX04291.1 - 0.051 13.6 0.9 0.3 11.2 0.2 1.9 1 1 1 2 2 2 0 YbbR-like protein Glutaredoxin2_C PF04399.8 EFX04291.1 - 0.075 12.6 0.0 0.086 12.4 0.0 1.1 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain CDC45 PF02724.9 EFX04293.1 - 0.069 11.1 2.9 0.1 10.6 2.0 1.1 1 0 0 1 1 1 0 CDC45-like protein AMP-binding PF00501.23 EFX04294.1 - 1.5e-82 277.2 0.0 2.3e-82 276.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CENP-K PF11802.3 EFX04295.1 - 1.9e-05 24.0 0.0 0.0013 18.0 0.0 2.2 2 0 0 2 2 2 1 Centromere-associated protein K HlyC PF02794.11 EFX04295.1 - 0.096 12.2 0.1 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 RTX toxin acyltransferase family Atg14 PF10186.4 EFX04295.1 - 1.6 7.6 6.4 2.8 6.8 4.4 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4407 PF14362.1 EFX04295.1 - 3.4 6.5 16.7 2.5 6.9 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Sigma70_ner PF04546.8 EFX04295.1 - 4.5 6.8 12.4 0.1 12.2 1.7 2.7 3 0 0 3 3 3 0 Sigma-70, non-essential region IncA PF04156.9 EFX04295.1 - 5.2 6.6 9.6 0.12 12.0 0.9 2.2 3 0 0 3 3 3 0 IncA protein Cu_amine_oxid PF01179.15 EFX04296.1 - 2.3e-91 306.6 0.0 2.9e-91 306.2 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.5 EFX04296.1 - 7.6e-05 22.5 0.0 0.00026 20.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) 2-Hacid_dh_C PF02826.14 EFX04298.1 - 1.1e-49 168.0 0.0 1.8e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX04298.1 - 1.6e-15 56.7 0.0 2.2e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFX04298.1 - 0.00014 21.7 0.0 0.0004 20.2 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.16 EFX04298.1 - 0.025 14.1 0.0 0.22 11.0 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain SUN PF03856.8 EFX04299.1 - 5.3e-81 271.5 15.0 5.3e-81 271.5 10.4 1.6 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) DNA_pol_viral_N PF00242.12 EFX04299.1 - 1.7 7.6 15.6 2.4 7.1 10.8 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain adh_short PF00106.20 EFX04300.1 - 1.7e-27 96.3 2.3 2.5e-27 95.8 1.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04300.1 - 2e-26 93.2 0.0 2.5e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX04300.1 - 1.1e-09 38.2 0.2 1.7e-09 37.6 0.2 1.2 1 0 0 1 1 1 1 KR domain DFP PF04127.10 EFX04300.1 - 0.028 14.0 3.0 0.069 12.7 2.1 1.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Eno-Rase_NADH_b PF12242.3 EFX04300.1 - 0.083 12.6 0.5 0.19 11.5 0.3 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Glyco_hydro_2_C PF02836.12 EFX04301.1 - 4.5e-99 331.1 0.0 6e-99 330.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.12 EFX04301.1 - 1.1e-51 175.4 0.0 2.2e-51 174.4 0.0 1.5 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.13 EFX04301.1 - 3.8e-45 153.4 0.1 9.3e-45 152.1 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 EFX04301.1 - 2.9e-16 59.8 0.3 6.9e-16 58.6 0.2 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Rieske PF00355.21 EFX04302.1 - 5.3e-15 54.7 0.0 9.3e-15 53.9 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Ring_hydroxyl_A PF00848.14 EFX04302.1 - 0.00037 20.2 0.3 0.0098 15.5 0.0 2.3 2 0 0 2 2 2 1 Ring hydroxylating alpha subunit (catalytic domain) PRA-PH PF01503.12 EFX04304.1 - 0.097 12.9 0.3 30 4.9 0.0 2.7 1 1 2 3 3 3 0 Phosphoribosyl-ATP pyrophosphohydrolase Acetyltransf_3 PF13302.1 EFX04305.1 - 1e-14 54.8 0.3 2.4e-14 53.7 0.0 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX04305.1 - 1.1e-05 25.3 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 EFX04305.1 - 0.014 15.2 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CytadhesinP1 PF12378.3 EFX04305.1 - 0.043 13.7 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 Trypsin-sensitive surface-exposed protein IMS PF00817.15 EFX04306.1 - 2.1e-37 128.2 0.0 4.1e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EFX04306.1 - 2e-17 63.3 0.0 5e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4414 PF14377.1 EFX04306.1 - 1.2e-07 31.6 9.1 0.00016 21.5 0.2 3.8 2 1 0 3 3 3 2 Domain of unknown function (DUF4414) BRCT PF00533.21 EFX04306.1 - 0.00039 20.5 0.0 0.0012 18.9 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EFX04306.1 - 0.00057 19.6 0.0 0.0031 17.3 0.0 2.3 2 0 0 2 2 2 1 twin BRCT domain UPF0029 PF01205.14 EFX04307.1 - 2.6e-20 72.1 0.0 5.2e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 tRNA-synt_1c PF00749.16 EFX04309.1 - 8.5e-95 317.0 0.0 1.2e-94 316.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EFX04309.1 - 1.3e-29 103.1 0.0 4.1e-29 101.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain Sdh5 PF03937.11 EFX04310.1 - 3.4e-24 84.3 1.0 9.2e-24 82.9 0.6 1.7 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase Peptidase_M48 PF01435.13 EFX04311.1 - 6.1e-34 117.5 1.7 6.5e-34 117.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M48 Glyco_hydro_16 PF00722.16 EFX04311.1 - 7.5e-07 28.6 2.5 1.4e-06 27.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 zf-CCCH PF00642.19 EFX04312.1 - 3.3e-14 52.1 32.4 8.3e-07 28.5 0.2 5.5 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Methyltransf_23 PF13489.1 EFX04312.1 - 1.3e-09 37.9 0.7 3.3e-09 36.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04312.1 - 0.00013 22.4 0.0 0.00078 20.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain FAD_binding_4 PF01565.18 EFX04313.1 - 7.9e-25 86.9 0.8 1.4e-24 86.1 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain Glyco_hydro_11 PF00457.12 EFX04313.1 - 0.019 14.2 0.2 0.044 13.1 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolases family 11 Dak1 PF02733.12 EFX04314.1 - 1.1e-109 366.0 8.5 1.5e-109 365.5 5.9 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 EFX04314.1 - 5.9e-43 146.5 4.0 5.9e-43 146.5 2.8 2.2 2 0 0 2 2 2 1 DAK2 domain Hpt PF01627.18 EFX04314.1 - 0.15 12.0 1.3 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 Hpt domain bZIP_1 PF00170.16 EFX04316.1 - 5e-07 29.5 7.7 1.4e-06 28.1 5.4 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX04316.1 - 0.002 17.9 7.0 0.002 17.9 4.8 2.0 1 1 1 2 2 2 1 Basic region leucine zipper MDFI PF15316.1 EFX04316.1 - 0.16 11.9 1.4 0.19 11.7 0.1 1.7 2 0 0 2 2 2 0 MyoD family inhibitor DUF966 PF06136.8 EFX04316.1 - 1.6 8.0 9.7 0.3 10.4 4.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF966) Prenyltransf PF01255.14 EFX04318.1 - 1.1e-85 286.2 0.0 2e-85 285.4 0.0 1.3 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase WD40 PF00400.27 EFX04319.1 - 1.3e-47 158.0 17.5 3e-10 39.5 0.8 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat PRP4 PF08799.6 EFX04319.1 - 6.4e-11 41.3 3.4 1.4e-10 40.2 2.4 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Nbas_N PF15492.1 EFX04319.1 - 0.021 13.9 0.0 1.1 8.2 0.0 2.5 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF4165 PF13752.1 EFX04319.1 - 0.14 11.8 0.1 1.3 8.7 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4165) DUF2188 PF09954.4 EFX04319.1 - 0.21 11.5 1.4 1.3 9.0 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) SKIP_SNW PF02731.10 EFX04320.1 - 3.7e-65 218.2 4.3 3.7e-65 218.2 3.0 2.3 2 0 0 2 2 2 1 SKIP/SNW domain DUF3554 PF12074.3 EFX04322.1 - 4.7e-74 249.8 6.5 6.9e-74 249.2 1.1 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 EFX04322.1 - 1.6e-36 124.4 67.9 2.8e-10 40.3 0.2 16.2 9 4 6 15 15 15 9 HEAT repeats HEAT PF02985.17 EFX04322.1 - 3.2e-36 120.1 35.6 0.0045 16.9 0.0 21.4 22 0 0 22 22 22 8 HEAT repeat HEAT_EZ PF13513.1 EFX04322.1 - 4.6e-23 81.0 80.1 1.2e-06 28.8 0.0 23.1 20 5 8 28 28 25 8 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EFX04322.1 - 4.6e-15 55.7 0.0 0.33 11.3 0.1 10.1 7 4 4 11 11 11 4 Vacuolar 14 Fab1-binding region ParcG PF10274.4 EFX04322.1 - 5.8e-12 45.8 4.3 0.00034 20.5 0.0 6.5 6 2 1 7 7 7 3 Parkin co-regulated protein CLASP_N PF12348.3 EFX04322.1 - 7.2e-12 45.1 0.0 0.0073 15.6 0.0 6.9 4 2 2 6 6 6 3 CLASP N terminal Adaptin_N PF01602.15 EFX04322.1 - 8.5e-11 40.8 4.6 6.6e-06 24.7 1.1 6.6 5 3 2 7 7 7 1 Adaptin N terminal region Cnd1 PF12717.2 EFX04322.1 - 4.7e-10 39.5 0.0 0.13 12.0 0.1 7.9 4 3 4 8 8 8 1 non-SMC mitotic condensation complex subunit 1 UME PF08064.8 EFX04322.1 - 1.8e-05 24.6 0.0 9.9 6.1 0.0 7.1 8 1 0 8 8 8 1 UME (NUC010) domain Ipi1_N PF12333.3 EFX04322.1 - 0.00044 20.1 6.3 0.02 14.8 0.1 5.9 7 0 0 7 7 7 1 Rix1 complex component involved in 60S ribosome maturation Cut8_C PF08559.5 EFX04323.1 - 5.7e-42 142.9 0.0 8e-42 142.4 0.0 1.2 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 EFX04323.1 - 1.2e-12 47.3 1.5 2.5e-12 46.3 1.0 1.6 1 0 0 1 1 1 1 Cut8 dimerisation domain Cut8_N PF14482.1 EFX04323.1 - 8.4e-07 28.8 2.4 1.6e-06 27.9 1.6 1.5 1 0 0 1 1 1 1 Cut8 proteasome-binding domain Thiolase_N PF00108.18 EFX04324.1 - 2.8e-76 255.9 2.7 5.6e-76 255.0 1.9 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EFX04324.1 - 9.1e-46 154.2 0.2 1.6e-45 153.4 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EFX04324.1 - 0.0054 16.2 5.3 0.011 15.2 1.1 2.8 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.5 EFX04324.1 - 0.016 15.2 0.0 0.051 13.5 0.0 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ScpA_ScpB PF02616.9 EFX04325.1 - 0.00043 19.9 5.8 0.00059 19.4 4.0 1.2 1 1 0 1 1 1 1 ScpA/B protein FlgN PF05130.7 EFX04325.1 - 0.0013 19.0 3.5 0.0018 18.5 2.4 1.1 1 0 0 1 1 1 1 FlgN protein DUF3829 PF12889.2 EFX04325.1 - 0.0016 17.7 3.1 0.0022 17.2 1.8 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3829) V-SNARE PF05008.10 EFX04325.1 - 0.005 16.9 7.7 0.2 11.8 2.2 3.1 1 1 1 2 2 2 1 Vesicle transport v-SNARE protein N-terminus ImcF-related_N PF14331.1 EFX04325.1 - 0.0097 14.8 0.5 0.013 14.4 0.4 1.2 1 0 0 1 1 1 1 ImcF-related N-terminal domain Ferritin PF00210.19 EFX04325.1 - 0.016 14.9 2.0 0.03 14.0 1.4 1.6 1 1 0 1 1 1 0 Ferritin-like domain FliJ PF02050.11 EFX04325.1 - 0.02 14.9 3.2 0.06 13.3 1.8 1.9 2 0 0 2 2 2 0 Flagellar FliJ protein MiaE PF06175.6 EFX04325.1 - 0.038 13.3 0.4 0.054 12.8 0.3 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) PMEI PF04043.10 EFX04325.1 - 0.038 13.8 0.7 0.16 11.8 0.3 1.8 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Prefoldin_2 PF01920.15 EFX04325.1 - 0.04 13.6 9.0 0.054 13.2 2.0 2.2 1 1 1 2 2 2 0 Prefoldin subunit AAA_13 PF13166.1 EFX04325.1 - 0.047 12.1 7.9 0.064 11.7 5.4 1.2 1 0 0 1 1 1 0 AAA domain Glyco_hydro_53 PF07745.8 EFX04325.1 - 0.051 12.3 0.1 0.18 10.5 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 53 CbiK PF06180.6 EFX04325.1 - 0.063 12.3 0.2 1 8.3 0.0 2.2 1 1 1 2 2 2 0 Cobalt chelatase (CbiK) RmuC PF02646.11 EFX04325.1 - 0.068 12.0 5.2 0.11 11.3 0.3 2.2 1 1 1 2 2 2 0 RmuC family Abi_C PF14355.1 EFX04325.1 - 0.1 12.5 0.2 12 5.8 0.0 2.8 2 1 1 3 3 3 0 Abortive infection C-terminus Allexi_40kDa PF05549.6 EFX04325.1 - 0.11 11.7 2.0 0.19 11.0 1.0 1.5 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF885 PF05960.6 EFX04325.1 - 0.12 11.4 1.6 0.13 11.4 1.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Sterile PF03015.14 EFX04325.1 - 0.12 12.6 0.4 0.44 10.8 0.2 1.9 1 1 1 2 2 2 0 Male sterility protein Cob_adeno_trans PF01923.13 EFX04325.1 - 0.14 11.9 5.7 3.3 7.4 0.6 2.3 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Osmo_CC PF08946.5 EFX04325.1 - 0.15 12.0 0.5 0.15 12.0 0.4 3.0 3 1 0 3 3 3 0 Osmosensory transporter coiled coil Med9 PF07544.8 EFX04325.1 - 0.17 11.6 4.6 2.5 7.8 0.4 2.9 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF3091 PF11291.3 EFX04325.1 - 0.18 11.7 3.0 1.1 9.2 1.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3091) Phasin PF05597.6 EFX04325.1 - 0.2 11.4 3.9 0.67 9.7 1.3 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.7 EFX04325.1 - 0.25 11.1 5.4 7 6.4 3.7 2.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 EFX04325.1 - 0.27 11.1 1.5 1.7 8.5 0.1 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin PF02996.12 EFX04325.1 - 0.27 10.8 8.3 2.6 7.7 0.4 3.1 2 1 1 3 3 3 0 Prefoldin subunit PRESAN PF09687.5 EFX04325.1 - 0.31 11.0 4.7 2.5 8.1 2.5 2.5 2 1 0 2 2 2 0 Plasmodium RESA N-terminal ATP-synt_B PF00430.13 EFX04325.1 - 0.46 10.2 6.1 0.74 9.6 4.3 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) SNARE PF05739.14 EFX04325.1 - 0.56 9.9 8.3 1.4 8.6 0.1 3.0 3 1 0 3 3 2 0 SNARE domain TPR_MLP1_2 PF07926.7 EFX04325.1 - 0.71 9.6 7.5 1.9 8.2 5.2 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Occludin_ELL PF07303.8 EFX04325.1 - 0.74 10.5 4.6 2.4 8.9 1.3 2.6 1 1 1 2 2 2 0 Occludin homology domain Syntaxin_2 PF14523.1 EFX04325.1 - 0.76 9.8 5.8 5.5 7.0 4.0 2.2 1 1 0 1 1 1 0 Syntaxin-like protein IncA PF04156.9 EFX04325.1 - 0.99 8.9 8.7 3 7.3 6.0 1.8 1 1 0 1 1 1 0 IncA protein Fib_alpha PF08702.5 EFX04325.1 - 1.4 9.0 5.7 2.3 8.3 2.7 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Zn_clus PF00172.13 EFX04326.1 - 3e-05 23.8 9.4 5e-05 23.1 6.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX04326.1 - 0.051 12.4 0.0 0.11 11.3 0.0 1.6 1 0 0 1 1 1 0 Fungal specific transcription factor domain FKBP_C PF00254.23 EFX04327.1 - 3.9e-25 87.7 0.1 4.5e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase VWA_2 PF13519.1 EFX04328.1 - 1.1e-10 41.8 0.0 2.1e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 EFX04328.1 - 3e-08 33.4 0.0 4.9e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.15 EFX04328.1 - 0.00038 19.7 1.8 0.0018 17.7 1.3 2.2 1 0 0 1 1 1 1 Ubiquitin interaction motif VWA PF00092.23 EFX04328.1 - 0.028 14.1 0.2 0.042 13.5 0.1 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain zf-C2H2_4 PF13894.1 EFX04329.1 - 0.0011 19.1 3.6 0.3 11.4 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX04329.1 - 0.029 14.7 7.4 0.33 11.3 0.4 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFX04329.1 - 0.044 14.0 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2H2_6 PF13912.1 EFX04329.1 - 0.18 11.7 1.8 17 5.4 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger PAT1 PF09770.4 EFX04329.1 - 0.64 8.1 15.4 0.86 7.7 10.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 p450 PF00067.17 EFX04330.1 - 1.3e-46 159.1 0.0 1.5e-46 158.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cellulase PF00150.13 EFX04331.1 - 3.4e-17 62.5 4.2 4.6e-17 62.1 2.9 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) NAD_binding_4 PF07993.7 EFX04332.1 - 8.3e-31 106.7 0.0 1.5e-30 105.9 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 EFX04332.1 - 5.6e-26 90.8 0.0 1.4e-25 89.5 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.16 EFX04332.1 - 1.8e-12 47.2 0.0 3.2e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.20 EFX04332.1 - 7e-05 23.0 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_10 PF13460.1 EFX04332.1 - 0.00018 21.5 0.1 0.3 11.0 0.1 3.7 2 1 0 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFX04332.1 - 0.12 11.2 0.0 0.36 9.6 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NmrA PF05368.8 EFX04332.1 - 0.22 10.7 0.0 0.38 9.9 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Peptidase_S64 PF08192.6 EFX04333.1 - 5.9e-05 21.6 0.2 0.0069 14.7 0.1 2.1 2 0 0 2 2 2 2 Peptidase family S64 Trypsin_2 PF13365.1 EFX04333.1 - 0.015 15.2 0.0 0.073 13.0 0.0 2.1 1 1 0 1 1 1 0 Trypsin-like peptidase domain SAP30_Sin3_bdg PF13867.1 EFX04334.1 - 6.7e-10 38.6 0.2 7.6e-09 35.3 0.1 2.3 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Fungal_trans PF04082.13 EFX04335.1 - 1.3e-23 83.1 0.7 2.7e-23 82.1 0.5 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04335.1 - 0.00093 19.0 11.8 0.0019 18.0 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mis14 PF08641.7 EFX04335.1 - 0.053 13.5 0.1 0.51 10.3 0.0 2.3 2 0 0 2 2 2 0 Kinetochore protein Mis14 like DUF2360 PF10152.4 EFX04335.1 - 3.1 8.0 7.1 2.9 8.1 1.6 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) peroxidase PF00141.18 EFX04336.1 - 3e-83 278.8 0.0 1.7e-45 155.2 0.0 2.4 2 1 0 2 2 2 2 Peroxidase DLH PF01738.13 EFX04337.1 - 1.6e-19 70.0 0.3 2.2e-17 63.1 0.2 2.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EFX04337.1 - 1.7e-09 37.5 0.1 3e-09 36.7 0.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFX04337.1 - 0.011 15.3 0.1 0.098 12.2 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EFX04337.1 - 0.049 12.8 0.8 0.91 8.6 0.0 2.5 3 0 0 3 3 3 0 Prolyl oligopeptidase family DUF3210 PF11489.3 EFX04338.1 - 4.5e-181 604.1 64.9 4.5e-181 604.1 45.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3210) Hom_end PF05204.9 EFX04339.1 - 0.12 12.3 0.6 13 5.8 0.0 2.5 2 2 0 2 2 2 0 Homing endonuclease Aldo_ket_red PF00248.16 EFX04340.1 - 0.0011 17.8 0.0 0.0015 17.4 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Clat_adaptor_s PF01217.15 EFX04341.1 - 1.1e-14 54.3 1.0 1.4e-13 50.7 0.7 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Syntaxin-6_N PF09177.6 EFX04342.1 - 0.009 16.3 0.9 0.022 15.1 0.0 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal Sec20 PF03908.8 EFX04342.1 - 0.032 13.9 1.0 0.073 12.7 0.0 2.1 2 0 0 2 2 2 0 Sec20 Adeno_PX PF05829.7 EFX04342.1 - 0.07 12.6 0.0 0.25 10.8 0.0 2.0 1 0 0 1 1 1 0 Adenovirus late L2 mu core protein (Protein X) TFIIA PF03153.8 EFX04342.1 - 1.7 8.4 10.7 2.4 7.9 7.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.17 EFX04343.1 - 1.5e-40 136.6 0.3 8.2e-20 70.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX04343.1 - 3.3e-28 97.4 0.0 1.4e-13 50.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX04343.1 - 3.5e-16 58.7 0.0 2.9e-07 30.2 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 EFX04343.1 - 1.1e-05 24.1 36.9 1.2e-05 23.9 25.6 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Nop14 PF04147.7 EFX04343.1 - 6.1 4.6 53.9 9.6 3.9 37.3 1.2 1 0 0 1 1 1 0 Nop14-like family V-SNARE_C PF12352.3 EFX04344.1 - 2.5e-15 56.3 0.3 2.5e-15 56.3 0.2 2.4 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 EFX04344.1 - 0.0004 20.0 0.0 0.0011 18.6 0.0 1.8 1 0 0 1 1 1 1 Sec20 Sigma70_r4 PF04545.11 EFX04344.1 - 0.014 14.6 0.1 0.035 13.4 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 MscS_porin PF12795.2 EFX04344.1 - 0.24 10.7 4.0 0.12 11.6 0.6 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Chitin_synth_1 PF01644.12 EFX04345.1 - 1.1e-80 269.1 0.3 1.7e-80 268.5 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EFX04345.1 - 2.7e-32 110.2 0.0 5.3e-32 109.3 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EFX04345.1 - 3.9e-24 84.9 1.4 1.4e-18 66.5 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EFX04345.1 - 8.3e-08 32.1 5.7 8.3e-08 32.1 4.0 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EFX04345.1 - 5.1e-07 29.7 0.0 1.8e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Ank_2 PF12796.2 EFX04346.1 - 6e-57 189.9 0.9 3e-14 53.1 0.0 7.2 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX04346.1 - 6.6e-43 144.3 7.8 1.6e-07 31.6 0.0 10.1 5 2 6 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX04346.1 - 2.5e-39 132.4 9.5 2.1e-05 24.6 0.0 11.0 5 2 6 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.25 EFX04346.1 - 5.9e-39 129.9 16.5 0.00062 19.4 0.0 13.5 15 1 0 15 15 15 11 Ankyrin repeat Ank_3 PF13606.1 EFX04346.1 - 2.8e-33 110.6 4.4 0.0018 18.2 0.0 12.8 13 0 0 13 13 13 8 Ankyrin repeat Pilt PF15453.1 EFX04347.1 - 0.049 13.3 6.1 0.072 12.7 4.2 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions HSP70 PF00012.15 EFX04347.1 - 0.53 8.1 7.0 0.7 7.7 4.9 1.1 1 0 0 1 1 1 0 Hsp70 protein RR_TM4-6 PF06459.7 EFX04347.1 - 2.5 7.9 13.4 3.4 7.4 9.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PGP_phosphatase PF09419.5 EFX04348.1 - 2.1e-61 206.1 0.0 3.1e-61 205.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 EFX04348.1 - 0.00081 19.0 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Brix PF04427.13 EFX04349.1 - 1.8e-33 115.8 0.5 3.2e-33 115.0 0.3 1.4 1 1 0 1 1 1 1 Brix domain Dioxygenase_C PF00775.16 EFX04350.1 - 4.5e-12 45.6 0.1 8.1e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 Dioxygenase ORC2 PF04084.9 EFX04351.1 - 5.1e-70 235.8 0.0 4.1e-69 232.9 0.0 1.9 1 1 0 1 1 1 1 Origin recognition complex subunit 2 DUF2890 PF11081.3 EFX04351.1 - 8.1 6.4 10.5 5.8 6.9 4.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) adh_short PF00106.20 EFX04353.1 - 3.4e-22 79.1 8.6 3.6e-17 62.7 0.6 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04353.1 - 1.4e-14 54.4 0.2 1.8e-14 54.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX04353.1 - 6.9e-07 29.1 6.2 2.7e-06 27.1 4.3 1.8 1 1 0 1 1 1 1 KR domain Carn_acyltransf PF00755.15 EFX04354.1 - 7.7e-171 569.1 0.0 8.8e-171 568.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PP2C PF00481.16 EFX04355.1 - 4.3e-36 124.6 0.0 3.9e-30 105.0 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C Bac_luciferase PF00296.15 EFX04356.1 - 8.1e-56 189.3 11.2 3.1e-55 187.4 7.8 1.7 1 1 0 1 1 1 1 Luciferase-like monooxygenase Amidase PF01425.16 EFX04357.1 - 1.5e-75 254.7 1.9 4.5e-50 170.7 0.0 2.9 2 1 0 2 2 2 2 Amidase PRELI PF04707.9 EFX04358.1 - 5.8e-39 133.1 0.0 7.5e-39 132.8 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family ubiquitin PF00240.18 EFX04359.1 - 4.9e-18 64.2 0.0 8.1e-18 63.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 EFX04359.1 - 3.2e-08 33.1 0.0 6.9e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.3 EFX04359.1 - 0.00011 21.7 0.0 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 EFX04359.1 - 0.00078 19.3 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Arginase PF00491.16 EFX04360.1 - 1.3e-82 277.2 1.1 1.8e-82 276.7 0.8 1.1 1 0 0 1 1 1 1 Arginase family DUF1772 PF08592.6 EFX04361.1 - 8e-16 58.0 10.7 1.8e-15 56.9 7.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) SET PF00856.23 EFX04361.1 - 5.3e-10 39.8 0.9 1.8e-08 34.8 0.0 3.3 4 1 0 4 4 4 1 SET domain NACHT PF05729.7 EFX04362.1 - 0.00011 21.9 0.1 0.00043 19.9 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 EFX04362.1 - 0.015 15.3 0.1 0.059 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain TPR_12 PF13424.1 EFX04362.1 - 0.016 15.1 0.7 0.1 12.5 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFX04362.1 - 0.022 14.6 1.1 0.15 12.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 EFX04362.1 - 0.023 14.3 0.1 0.26 10.9 0.0 3.0 3 0 0 3 3 3 0 TPR repeat AAA_16 PF13191.1 EFX04362.1 - 0.04 13.9 0.0 0.29 11.0 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 EFX04362.1 - 0.064 13.1 0.0 0.49 10.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 EFX04362.1 - 0.079 12.7 0.0 0.34 10.6 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 EFX04362.1 - 0.091 12.5 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UPF0079 PF02367.12 EFX04362.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 TPR_10 PF13374.1 EFX04362.1 - 0.28 11.1 1.7 1.7 8.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Plus-3 PF03126.13 EFX04363.1 - 2.1e-30 104.9 0.0 5.4e-30 103.6 0.0 1.8 1 0 0 1 1 1 1 Plus-3 domain NmrA PF05368.8 EFX04364.1 - 2.8e-20 72.5 0.0 3.6e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX04364.1 - 2.3e-14 53.7 4.2 2.3e-14 53.7 2.9 1.6 2 0 0 2 2 2 1 NADH(P)-binding Saccharop_dh PF03435.13 EFX04364.1 - 0.00053 19.0 0.1 0.00071 18.6 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 EFX04364.1 - 0.0049 17.2 0.4 0.014 15.8 0.3 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.19 EFX04364.1 - 0.0049 17.1 0.3 0.017 15.4 0.2 1.9 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EFX04364.1 - 0.13 10.9 0.0 0.29 9.8 0.0 1.5 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1416 PF07210.7 EFX04364.1 - 0.75 9.4 4.8 8.5 6.0 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1416) adh_short PF00106.20 EFX04364.1 - 5.6 6.8 12.5 0.38 10.6 2.4 2.8 2 2 0 2 2 2 0 short chain dehydrogenase YrhK PF14145.1 EFX04365.1 - 0.00078 19.0 20.6 0.0046 16.5 1.9 4.9 2 2 2 4 4 4 3 YrhK-like protein Alg6_Alg8 PF03155.10 EFX04366.1 - 3.5e-141 471.2 29.3 4.5e-141 470.8 20.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Transglut_core PF01841.14 EFX04367.1 - 1.1e-14 54.6 0.0 2.4e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF3987 PF13148.1 EFX04367.1 - 0.16 10.5 0.8 0.28 9.7 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) CDC45 PF02724.9 EFX04368.1 - 3.6e-221 735.5 0.0 1.3e-196 654.4 0.0 3.1 1 1 2 3 3 3 2 CDC45-like protein XPG_I_2 PF12813.2 EFX04368.1 - 9.6e-50 169.3 0.0 2.4e-49 168.0 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.13 EFX04368.1 - 0.018 15.1 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 XPG I-region YjeF_N PF03853.10 EFX04368.1 - 0.15 11.6 0.4 0.36 10.4 0.3 1.6 1 0 0 1 1 1 0 YjeF-related protein N-terminus Vfa1 PF08432.5 EFX04368.1 - 0.48 10.4 19.0 0.02 14.9 8.1 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SGL PF08450.7 EFX04369.1 - 1.6e-25 89.8 0.1 4.5e-25 88.4 0.0 1.9 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 EFX04369.1 - 4.5e-05 23.3 0.0 0.00015 21.7 0.0 1.9 1 1 0 1 1 1 1 Arylesterase Str_synth PF03088.11 EFX04369.1 - 0.0018 18.2 0.0 0.0084 16.1 0.0 2.1 1 1 0 1 1 1 1 Strictosidine synthase NHL PF01436.16 EFX04369.1 - 0.62 10.1 6.5 2.2 8.3 0.7 3.4 3 0 0 3 3 3 0 NHL repeat ADH_zinc_N PF00107.21 EFX04370.1 - 1.8e-21 76.0 0.3 5.4e-21 74.4 0.2 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX04370.1 - 7.5e-17 62.4 0.2 2e-16 61.0 0.0 1.8 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX04370.1 - 2.2e-10 40.2 0.0 1.4e-08 34.4 0.0 2.4 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain DnaJ PF00226.26 EFX04371.1 - 7.4e-12 44.8 0.0 1.1e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 EFX04372.1 - 1.3e-07 30.9 1.2 2 8.5 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFX04372.1 - 2.8e-07 30.3 0.4 0.064 13.1 0.0 4.6 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX04372.1 - 9.3e-06 25.8 3.5 0.045 14.1 0.1 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX04372.1 - 1.4e-05 24.9 0.4 1.1 9.5 0.0 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX04372.1 - 1.9e-05 25.1 13.1 0.35 11.5 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.1 EFX04372.1 - 0.13 12.1 1.8 0.75 9.8 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFX04372.1 - 0.53 11.0 12.8 21 6.1 0.1 5.8 6 1 0 6 6 6 0 Tetratricopeptide repeat Sec63 PF02889.11 EFX04375.1 - 5.6e-37 127.6 0.2 8.1e-37 127.1 0.1 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 EFX04375.1 - 1.3e-25 89.8 0.0 2.7e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX04375.1 - 2.2e-10 40.2 0.0 6.4e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX04375.1 - 2.8e-07 30.5 0.0 5.4e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EFX04375.1 - 0.0016 18.6 0.0 0.0041 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain SNF2_N PF00176.18 EFX04375.1 - 0.0065 15.2 0.0 0.011 14.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2847 PF11009.3 EFX04375.1 - 0.01 15.3 0.0 0.055 13.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2847) AAA_19 PF13245.1 EFX04375.1 - 0.016 14.9 0.0 0.047 13.4 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain T2SE PF00437.15 EFX04375.1 - 0.025 13.5 0.0 0.083 11.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein SAM_1 PF00536.25 EFX04375.1 - 0.12 12.5 0.0 11 6.3 0.0 2.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF4238 PF14022.1 EFX04376.1 - 2.2e-21 76.3 0.0 9.6e-21 74.2 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF4238) Ribosomal_L7Ae PF01248.21 EFX04377.1 - 1.5e-21 75.6 0.5 2.7e-21 74.8 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EFX04377.1 - 0.019 14.8 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 RNase P subunit Pop3 DAO PF01266.19 EFX04378.1 - 1.3e-18 67.0 3.6 3.9e-18 65.4 2.5 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX04378.1 - 0.0017 17.2 0.8 0.0021 16.9 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 EFX04378.1 - 0.0019 18.2 0.2 0.0073 16.3 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX04378.1 - 0.0035 17.1 0.0 0.0069 16.1 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFX04378.1 - 0.0069 16.2 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX04378.1 - 0.088 13.2 0.7 0.19 12.1 0.5 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase WAC_Acf1_DNA_bd PF10537.4 EFX04380.1 - 4.4e-38 129.5 0.2 1.4e-37 127.9 0.1 2.0 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 EFX04380.1 - 1.6e-18 66.1 0.5 2.7e-18 65.4 0.3 1.4 1 0 0 1 1 1 1 DDT domain WHIM2 PF15613.1 EFX04380.1 - 8.9e-13 47.6 0.4 1.8e-12 46.6 0.3 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 WHIM1 PF15612.1 EFX04380.1 - 7.9e-05 22.4 0.0 0.00029 20.6 0.0 2.0 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 MFS_1 PF07690.11 EFX04382.1 - 1.7e-06 26.9 20.1 1.7e-06 26.9 13.9 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFX04382.1 - 3.6e-06 26.5 3.1 3.6e-06 26.5 2.1 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Methyltransf_11 PF08241.7 EFX04383.1 - 3.6e-14 53.0 0.0 6.4e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX04383.1 - 1.1e-09 38.1 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04383.1 - 1.4e-09 38.2 0.0 2.6e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04383.1 - 1.8e-09 37.9 0.0 3.2e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04383.1 - 2.8e-09 37.5 0.0 7.7e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04383.1 - 7.1e-07 28.9 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX04383.1 - 3e-05 24.0 0.8 8.3e-05 22.6 0.5 1.7 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFX04383.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Acyl_transf_3 PF01757.17 EFX04384.1 - 5e-24 84.7 21.4 6.6e-24 84.3 14.8 1.3 1 1 0 1 1 1 1 Acyltransferase family CoA_trans PF01144.18 EFX04385.1 - 2.7e-97 324.1 0.9 2.5e-59 200.0 0.0 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.1 EFX04385.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain Metallophos PF00149.23 EFX04386.1 - 7.1e-18 64.7 0.1 1.4e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 EFX04386.1 - 1.7e-09 37.5 0.1 3.9e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C PhoD PF09423.5 EFX04386.1 - 1.8e-08 33.4 0.4 1.4e-07 30.5 0.3 1.9 2 0 0 2 2 2 1 PhoD-like phosphatase Metallophos_2 PF12850.2 EFX04386.1 - 0.02 14.7 0.0 0.051 13.4 0.0 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain fn3 PF00041.16 EFX04386.1 - 0.087 12.9 1.6 0.19 11.8 1.1 1.5 1 0 0 1 1 1 0 Fibronectin type III domain CLPTM1 PF05602.7 EFX04387.1 - 5.4e-150 499.9 0.0 6.8e-150 499.6 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF4542 PF15075.1 EFX04387.1 - 0.031 14.2 0.3 0.13 12.1 0.0 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4542) Formyl_trans_N PF00551.14 EFX04388.1 - 1.3e-37 129.0 0.2 1.8e-37 128.6 0.2 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.20 EFX04388.1 - 9.5e-11 40.9 0.1 5.2e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 ACT domain ACT_6 PF13740.1 EFX04388.1 - 1.8e-05 24.3 0.1 8.2e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.1 EFX04388.1 - 0.045 14.1 0.0 0.15 12.4 0.0 2.0 1 0 0 1 1 1 0 ACT domain Peptidase_S8 PF00082.17 EFX04389.1 - 1.8e-18 66.7 0.0 2.9e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Cullin PF00888.17 EFX04390.1 - 5.1e-196 652.7 4.7 6.8e-196 652.3 3.3 1.1 1 0 0 1 1 1 1 Cullin family PDZ_1 PF12812.2 EFX04390.1 - 8.6e-52 172.9 0.0 1.9e-32 110.9 0.0 2.7 2 0 0 2 2 2 2 PDZ-like domain Cullin_Nedd8 PF10557.4 EFX04390.1 - 7.8e-27 92.8 3.5 3.1e-26 90.9 2.4 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Trypsin_2 PF13365.1 EFX04390.1 - 9.4e-15 54.6 0.3 2.3e-13 50.1 0.0 2.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 EFX04390.1 - 2.4e-14 52.9 0.2 0.00022 21.0 0.0 4.7 4 0 0 4 4 4 4 PDZ domain PDZ PF00595.19 EFX04390.1 - 1.1e-07 31.9 0.0 0.044 13.9 0.0 3.7 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 EFX04390.1 - 0.0048 16.6 0.5 0.36 10.6 0.1 3.5 3 0 0 3 3 3 1 Tricorn protease PDZ domain Peptidase_S7 PF00949.16 EFX04390.1 - 0.058 12.8 0.5 0.23 10.8 0.3 2.0 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease PLDc PF00614.17 EFX04391.1 - 5.4e-15 54.6 1.5 1.7e-07 30.8 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 EFX04391.1 - 1.3e-11 44.3 0.0 7.2e-05 22.5 0.0 3.4 3 0 0 3 3 3 3 PLD-like domain Methyltransf_16 PF10294.4 EFX04392.1 - 2.6e-41 140.9 0.0 3.2e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EFX04392.1 - 0.0011 19.5 0.0 0.0016 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04392.1 - 0.069 12.7 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 EFX04392.1 - 0.095 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PBP PF01161.15 EFX04393.1 - 5.6e-09 35.9 0.0 8.9e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ETF PF01012.16 EFX04394.1 - 3.4e-41 140.7 0.6 7.6e-41 139.5 0.4 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.14 EFX04394.1 - 4.5e-35 119.1 0.3 1.1e-34 117.9 0.2 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Tau95 PF09734.4 EFX04395.1 - 4.4e-53 180.6 0.0 7.9e-53 179.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit BUD22 PF09073.5 EFX04395.1 - 9.1 5.2 45.9 14 4.5 31.8 1.2 1 0 0 1 1 1 0 BUD22 zf-C2H2_jaz PF12171.3 EFX04396.1 - 0.00093 19.2 6.7 0.031 14.4 0.1 4.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EFX04396.1 - 0.019 15.2 20.4 0.15 12.4 0.1 5.0 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-met PF12874.2 EFX04396.1 - 0.057 13.6 13.4 0.078 13.2 0.1 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EFX04396.1 - 0.057 13.7 0.2 0.057 13.7 0.1 5.5 7 0 0 7 7 7 0 C2H2-type zinc finger FTHFS PF01268.14 EFX04398.1 - 9.8e-257 852.3 0.1 1.3e-256 851.9 0.1 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 EFX04398.1 - 2.6e-68 228.1 2.0 4.3e-68 227.4 0.3 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 EFX04398.1 - 8e-38 129.0 0.3 1.6e-37 128.0 0.2 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Dala_Dala_lig_C PF07478.8 EFX04398.1 - 0.085 12.2 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus MFS_1 PF07690.11 EFX04399.1 - 1.1e-27 96.7 26.1 3.8e-27 94.9 17.9 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4212 PF13937.1 EFX04399.1 - 0.078 12.9 0.1 0.078 12.9 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) Beta-lactamase PF00144.19 EFX04400.1 - 7.5e-45 153.3 7.1 1.4e-44 152.4 4.9 1.3 1 0 0 1 1 1 1 Beta-lactamase NTF2 PF02136.15 EFX04400.1 - 1.3e-28 99.7 0.2 2.2e-28 98.9 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF3471 PF11954.3 EFX04400.1 - 6e-07 29.2 0.0 1.4e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) DUF4518 PF15008.1 EFX04400.1 - 0.32 9.9 0.1 0.63 9.0 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Fungal_trans PF04082.13 EFX04401.1 - 2.9e-12 46.0 0.0 6.2e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04401.1 - 1.2e-05 25.1 7.1 2.3e-05 24.1 5.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PNGaseA PF12222.3 EFX04402.1 - 2.5e-144 481.3 4.0 3.6e-144 480.7 2.8 1.2 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Not1 PF04054.10 EFX04403.1 - 3.2e-102 342.2 0.1 6.6e-102 341.2 0.1 1.5 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 EFX04403.1 - 3.2e-46 156.6 1.6 8.5e-46 155.2 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) Fungal_trans PF04082.13 EFX04404.1 - 4.7e-13 48.6 0.0 9.1e-13 47.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04404.1 - 2e-05 24.3 11.0 3.5e-05 23.6 7.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_20 PF00728.17 EFX04405.1 - 2.5e-32 112.4 3.0 5.6e-27 94.8 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.10 EFX04405.1 - 2.6e-05 24.7 0.0 0.00017 22.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 VIT1 PF01988.14 EFX04405.1 - 0.14 11.6 0.3 0.26 10.7 0.2 1.3 1 0 0 1 1 1 0 VIT family p450 PF00067.17 EFX04406.1 - 4.1e-43 147.5 0.0 1.6e-42 145.6 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF1242 PF06842.7 EFX04407.1 - 1.9e-18 65.6 0.4 2.7e-18 65.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) DUF3317 PF11779.3 EFX04407.1 - 0.064 12.6 0.7 0.064 12.6 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3317) Peptidase_M50B PF13398.1 EFX04408.1 - 2.9e-54 183.4 17.8 3.9e-54 183.0 12.3 1.1 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M41 PF01434.13 EFX04408.1 - 0.023 14.1 0.1 0.036 13.5 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M41 Na_Pi_cotrans PF02690.10 EFX04408.1 - 1.4 8.6 8.4 0.095 12.4 1.5 2.2 2 0 0 2 2 2 0 Na+/Pi-cotransporter Peptidase_M50 PF02163.17 EFX04408.1 - 3.9 6.3 10.8 0.8 8.6 4.3 2.5 2 1 0 2 2 2 0 Peptidase family M50 zf-DHHC PF01529.15 EFX04409.1 - 1.6e-33 115.5 3.3 1.6e-33 115.5 2.3 1.8 1 1 1 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.1 EFX04409.1 - 0.039 13.7 2.1 0.083 12.6 1.5 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily DZR PF12773.2 EFX04409.1 - 1.4 8.8 9.4 2.4 8.0 6.5 1.3 1 0 0 1 1 1 0 Double zinc ribbon SR-25 PF10500.4 EFX04409.1 - 3.9 6.8 7.2 7.2 6.0 5.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Abhydrolase_3 PF07859.8 EFX04410.1 - 1.9e-42 145.2 4.9 5.1e-41 140.5 3.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX04410.1 - 2e-05 24.4 1.5 3.3e-05 23.6 1.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2424 PF10340.4 EFX04410.1 - 0.0029 16.3 0.0 0.0041 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) COesterase PF00135.23 EFX04410.1 - 0.0042 15.8 1.8 0.044 12.5 1.2 2.0 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.4 EFX04410.1 - 0.0059 15.8 0.2 0.015 14.5 0.1 1.6 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydro_lipase PF04083.11 EFX04410.1 - 0.0091 15.3 0.0 0.022 14.0 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region AXE1 PF05448.7 EFX04410.1 - 0.012 14.1 0.1 0.022 13.2 0.1 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 EFX04410.1 - 0.015 14.5 1.1 1.1 8.4 0.1 2.5 2 1 0 2 2 2 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 EFX04410.1 - 0.089 11.6 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Pkinase PF00069.20 EFX04411.1 - 7.1e-72 241.6 0.0 9.2e-72 241.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04411.1 - 4.8e-31 107.7 0.0 6.8e-31 107.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EFX04411.1 - 1.6e-12 47.7 0.4 1.6e-12 47.7 0.3 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFX04411.1 - 2.8e-09 36.3 0.0 5.5e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C2 PF00168.25 EFX04411.1 - 7.7e-08 32.0 0.0 2e-07 30.7 0.0 1.8 1 1 0 1 1 1 1 C2 domain Kdo PF06293.9 EFX04411.1 - 0.048 12.7 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EFX04411.1 - 0.082 12.4 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.4 EFX04411.1 - 0.17 11.2 0.1 0.39 10.0 0.0 1.5 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Cript PF10235.4 EFX04412.1 - 1.8e-20 73.0 4.0 3e-20 72.3 1.5 1.9 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT DZR PF12773.2 EFX04412.1 - 0.0012 18.6 0.7 0.015 15.1 0.1 2.1 2 0 0 2 2 2 1 Double zinc ribbon zf-AD PF07776.10 EFX04412.1 - 0.11 12.5 0.6 9.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) zf-ribbon_3 PF13248.1 EFX04412.1 - 0.86 8.8 4.6 0.99 8.7 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain HMA PF00403.21 EFX04412.1 - 1 9.5 3.4 3.1 7.9 0.1 2.3 2 0 0 2 2 2 0 Heavy-metal-associated domain ADH_N PF08240.7 EFX04412.1 - 3.6 7.3 6.1 82 3.0 4.2 2.7 1 1 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain IU_nuc_hydro PF01156.14 EFX04413.1 - 9e-80 268.1 0.2 1.1e-79 267.9 0.2 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MCPsignal PF00015.16 EFX04414.1 - 0.021 14.3 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain G-patch_2 PF12656.2 EFX04415.1 - 6.7e-06 25.8 0.1 6.7e-06 25.8 0.0 4.4 2 1 1 4 4 4 1 DExH-box splicing factor binding site G-patch PF01585.18 EFX04415.1 - 7.9e-06 25.5 0.1 0.00022 20.9 0.0 2.9 3 0 0 3 3 3 1 G-patch domain DUF936 PF06075.7 EFX04415.1 - 0.0045 15.9 21.8 0.0056 15.6 15.1 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF936) MIP-T3 PF10243.4 EFX04415.1 - 0.045 12.2 52.0 0.062 11.7 36.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PLRV_ORF5 PF01690.12 EFX04415.1 - 1.3 8.1 24.2 1.8 7.6 16.8 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Hid1 PF12722.2 EFX04415.1 - 2.4 5.6 19.1 3 5.3 13.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Parvo_coat PF00740.13 EFX04415.1 - 5.3 5.8 11.1 8.1 5.2 7.7 1.4 1 0 0 1 1 1 0 Parvovirus coat protein VP2 TRAPPC-Trs85 PF12739.2 EFX04416.1 - 2.2e-113 379.0 0.2 2.2e-113 379.0 0.1 2.5 3 0 0 3 3 3 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Zn_clus PF00172.13 EFX04416.1 - 6.1e-08 32.4 8.9 1.2e-07 31.4 6.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX04416.1 - 0.0071 15.2 0.0 0.021 13.6 0.0 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain FimP PF09766.4 EFX04416.1 - 0.32 9.9 6.7 0.55 9.2 4.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein Suf PF05843.9 EFX04416.1 - 0.49 10.0 3.8 1.1 8.8 2.7 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Metallophos PF00149.23 EFX04417.1 - 3.3e-43 147.4 1.0 4.8e-43 146.8 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Vps51 PF08700.6 EFX04417.1 - 1.4e-15 56.8 3.5 1.4e-15 56.8 2.4 2.6 3 0 0 3 3 3 1 Vps51/Vps67 COG2 PF06148.6 EFX04417.1 - 0.027 14.3 2.5 0.92 9.3 0.1 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Laminin_B PF00052.13 EFX04417.1 - 0.032 13.8 0.3 0.082 12.5 0.2 1.7 1 0 0 1 1 1 0 Laminin B (Domain IV) DUF2383 PF09537.5 EFX04417.1 - 0.25 11.5 5.2 1.4 9.1 0.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) MA-Mit PF09245.5 EFX04417.1 - 0.5 9.6 3.1 12 5.0 0.1 2.2 2 0 0 2 2 2 0 Mycoplasma arthritidis-derived mitogen Atg14 PF10186.4 EFX04417.1 - 6.2 5.6 15.2 0.98 8.2 1.3 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Crystall PF00030.14 EFX04418.1 - 9e-06 25.4 0.1 0.00023 20.9 0.0 2.4 2 0 0 2 2 2 1 Beta/Gamma crystallin Syntaxin-6_N PF09177.6 EFX04418.1 - 0.069 13.5 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Snf7 PF03357.16 EFX04420.1 - 6.7e-16 58.1 13.6 1.1e-15 57.4 9.4 1.3 1 0 0 1 1 1 1 Snf7 FlxA PF14282.1 EFX04420.1 - 2.4 8.1 12.7 2.3 8.2 0.7 2.8 3 0 0 3 3 3 0 FlxA-like protein Sua5_yciO_yrdC PF01300.13 EFX04421.1 - 6.1e-49 165.6 0.0 8.7e-49 165.1 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 EFX04421.1 - 6.7e-25 87.5 0.0 1.8e-24 86.1 0.0 1.7 1 1 0 1 1 1 1 Putative GTP-binding controlling metal-binding DUF2962 PF11176.3 EFX04423.1 - 3.2e-44 150.2 2.7 3.7e-44 150.0 1.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) HTH_32 PF13565.1 EFX04423.1 - 0.21 12.3 3.5 5.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain FKBP_C PF00254.23 EFX04424.1 - 8.7e-29 99.4 0.0 4e-28 97.2 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase Utp14 PF04615.8 EFX04424.1 - 0.37 8.8 41.1 0.56 8.3 11.2 2.3 2 0 0 2 2 2 0 Utp14 protein Aldedh PF00171.17 EFX04425.1 - 1.1e-51 175.6 0.0 5.5e-40 137.0 0.0 3.5 2 1 0 2 2 2 2 Aldehyde dehydrogenase family COPIIcoated_ERV PF07970.7 EFX04426.1 - 4.1e-32 111.5 0.0 5.7e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EFX04426.1 - 3.2e-22 78.3 0.0 5e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Colicin_V PF02674.11 EFX04426.1 - 0.09 12.6 0.1 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Colicin V production protein LSM PF01423.17 EFX04427.1 - 3.1e-19 68.2 0.7 3.6e-19 68.0 0.5 1.1 1 0 0 1 1 1 1 LSM domain MIF PF01187.13 EFX04428.1 - 4.3e-09 36.4 0.0 6.6e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Methyltransf_33 PF10017.4 EFX04429.1 - 9.1e-31 106.3 0.0 1.9e-30 105.3 0.0 1.6 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.11 EFX04429.1 - 6.3e-15 55.2 0.1 1e-13 51.2 0.1 2.4 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.2 EFX04429.1 - 2.1e-05 24.8 0.2 9.9e-05 22.6 0.1 2.3 2 0 0 2 2 2 1 DinB superfamily Methyltransf_25 PF13649.1 EFX04429.1 - 0.0041 17.4 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain SpoIIIAH PF12685.2 EFX04430.1 - 1.2 8.6 3.7 1.5 8.2 2.6 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein MAP65_ASE1 PF03999.7 EFX04430.1 - 4.6 5.7 8.7 5.2 5.5 6.1 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF566 PF04484.7 EFX04430.1 - 4.6 6.6 11.8 5.1 6.5 8.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) Macoilin PF09726.4 EFX04430.1 - 7.9 4.6 11.2 8.7 4.4 7.8 1.0 1 0 0 1 1 1 0 Transmembrane protein Myosin_head PF00063.16 EFX04431.1 - 2.3e-232 772.9 0.6 3.7e-232 772.2 0.4 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 EFX04431.1 - 1.9e-37 128.5 0.0 4e-37 127.4 0.0 1.6 1 0 0 1 1 1 1 Myosin tail SH3_1 PF00018.23 EFX04431.1 - 2.9e-12 45.7 0.2 5.2e-12 44.9 0.2 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFX04431.1 - 4.8e-11 42.0 0.1 1e-10 41.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFX04431.1 - 2e-08 33.5 0.1 4.2e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.7 EFX04431.1 - 0.0012 18.2 0.2 0.39 10.0 0.0 2.3 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain IQ PF00612.22 EFX04431.1 - 0.0032 16.9 10.2 0.11 12.1 2.0 2.8 1 1 1 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.1 EFX04431.1 - 0.005 16.9 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFX04431.1 - 0.014 14.5 0.0 0.035 13.1 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.1 EFX04431.1 - 0.035 14.9 0.0 0.12 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain DUF552 PF04472.7 EFX04431.1 - 0.06 13.2 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF552) ABC_tran PF00005.22 EFX04431.1 - 0.12 12.6 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.1 EFX04431.1 - 0.15 12.4 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFX04431.1 - 0.15 11.6 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Reo_sigmaC PF04582.7 EFX04432.1 - 4.2 6.4 31.6 0.21 10.7 0.5 5.5 3 2 2 6 6 6 0 Reovirus sigma C capsid protein Prp18 PF02840.10 EFX04434.1 - 9.8e-49 164.9 0.3 2.1e-48 163.8 0.0 1.7 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.6 EFX04434.1 - 9.3e-09 34.4 2.0 9.3e-09 34.4 1.4 3.4 4 0 0 4 4 4 1 pre-mRNA processing factor 4 (PRP4) like CAF-1_p150 PF11600.3 EFX04434.1 - 5.5 6.3 27.6 9.3 5.5 19.1 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CDC27 PF09507.5 EFX04434.1 - 7.3 5.6 18.9 11 5.1 13.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Fe-ADH PF00465.14 EFX04435.1 - 2.6e-99 332.3 0.0 3.2e-99 332.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 EFX04435.1 - 8.1e-14 51.5 0.0 4e-11 42.6 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.1 EFX04435.1 - 0.012 14.9 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Med6 PF04934.9 EFX04436.1 - 3.5e-37 127.0 0.5 5.2e-37 126.5 0.0 1.5 2 0 0 2 2 2 1 MED6 mediator sub complex component DUF3449 PF11931.3 EFX04436.1 - 0.17 11.4 7.2 0.78 9.2 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Apt1 PF10351.4 EFX04436.1 - 0.3 9.8 11.2 0.44 9.3 7.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Prothymosin PF03247.9 EFX04436.1 - 0.46 10.6 27.2 0.61 10.2 0.6 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family TLP-20 PF06088.6 EFX04436.1 - 0.53 9.9 9.3 0.73 9.4 0.7 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) BUD22 PF09073.5 EFX04436.1 - 0.56 9.2 23.0 0.87 8.5 16.0 1.2 1 0 0 1 1 1 0 BUD22 Myc_N PF01056.13 EFX04436.1 - 1.5 7.8 13.5 0.044 12.9 3.1 2.2 2 0 0 2 2 2 0 Myc amino-terminal region FAM176 PF14851.1 EFX04436.1 - 2.1 7.9 13.4 0.65 9.6 2.6 2.5 2 0 0 2 2 2 0 FAM176 family Sigma70_ner PF04546.8 EFX04436.1 - 3.1 7.3 20.6 0.27 10.8 7.5 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.9 EFX04436.1 - 9.9 4.0 22.6 0.39 8.6 6.0 2.1 2 0 0 2 2 2 0 CDC45-like protein Rad51 PF08423.6 EFX04437.1 - 2e-131 436.5 0.0 2.5e-131 436.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 EFX04437.1 - 4.3e-15 55.6 0.0 6.3e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EFX04437.1 - 4.9e-10 38.9 0.0 6.7e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 EFX04437.1 - 1.4e-09 37.3 0.0 2.8e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.1 EFX04437.1 - 1.3e-06 28.5 0.0 3.7e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_22 PF13401.1 EFX04437.1 - 0.0088 16.1 0.0 0.032 14.3 0.0 1.9 2 1 0 2 2 2 1 AAA domain PAXNEB PF05625.6 EFX04437.1 - 0.021 13.6 0.1 0.056 12.2 0.0 1.6 2 0 0 2 2 2 0 PAXNEB protein RNA_pol_L_2 PF13656.1 EFX04438.1 - 2.5e-20 71.6 0.1 3.2e-20 71.3 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 EFX04438.1 - 8.5e-07 28.0 0.0 1.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Iso_dh PF00180.15 EFX04439.1 - 7.6e-74 248.7 0.0 8.9e-74 248.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DHFR_2 PF06442.6 EFX04439.1 - 0.031 13.9 0.0 2.8 7.6 0.0 2.5 2 0 0 2 2 2 0 R67 dihydrofolate reductase CP2 PF04516.10 EFX04440.1 - 7e-82 274.0 0.0 1.3e-81 273.1 0.0 1.4 1 0 0 1 1 1 1 CP2 transcription factor Tektin PF03148.9 EFX04440.1 - 0.004 15.7 0.0 0.0066 15.0 0.0 1.2 1 0 0 1 1 1 1 Tektin family CG-1 PF03859.11 EFX04440.1 - 0.02 14.4 0.1 0.25 10.8 0.0 2.3 2 0 0 2 2 2 0 CG-1 domain TMF_DNA_bd PF12329.3 EFX04440.1 - 0.056 13.2 0.5 0.11 12.3 0.4 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding AKNA PF12443.3 EFX04440.1 - 0.066 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF2681 PF10883.3 EFX04440.1 - 0.19 11.9 0.1 0.34 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Gti1_Pac2 PF09729.4 EFX04442.1 - 0.024 14.4 0.1 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family FBPase PF00316.15 EFX04443.1 - 9.4e-122 405.8 0.0 1.1e-121 405.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 EFX04443.1 - 0.074 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family Cu-oxidase_3 PF07732.10 EFX04444.1 - 1.6e-38 131.0 4.3 1.6e-38 131.0 3.0 2.4 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 EFX04444.1 - 2.9e-35 121.5 1.4 9e-35 119.9 0.5 2.1 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX04444.1 - 6.1e-25 87.3 0.7 6.1e-25 87.3 0.5 3.1 3 1 0 3 3 3 1 Multicopper oxidase Pro_CA PF00484.14 EFX04445.1 - 3e-45 153.9 0.2 3.7e-45 153.6 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase AAA PF00004.24 EFX04446.1 - 1.9e-15 57.2 0.0 5.9e-15 55.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFX04446.1 - 0.00017 21.2 0.0 0.00041 20.0 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 EFX04446.1 - 0.00075 19.6 0.4 0.0063 16.6 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFX04446.1 - 0.002 17.8 0.0 0.0073 16.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EFX04446.1 - 0.0055 17.5 0.1 0.02 15.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EFX04446.1 - 0.0099 15.7 0.0 0.038 13.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX04446.1 - 0.021 14.8 0.0 0.058 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 EFX04446.1 - 0.028 14.7 0.1 0.28 11.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain Asp PF00026.18 EFX04447.1 - 2.4e-50 171.6 1.3 3.3e-50 171.1 0.9 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX04447.1 - 9.2e-09 35.4 0.1 3e-08 33.7 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EFX04447.1 - 2.6e-05 24.6 2.0 0.023 15.1 0.1 3.4 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 EFX04447.1 - 0.00046 19.7 0.2 0.0015 18.0 0.1 1.9 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.1 EFX04447.1 - 0.005 16.6 0.1 0.16 11.7 0.1 2.6 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease INCENP_ARK-bind PF03941.10 EFX04449.1 - 5e-20 71.1 0.7 5e-20 71.1 0.5 2.9 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region Acetyltransf_1 PF00583.19 EFX04450.1 - 2.7e-07 30.5 0.0 4.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFX04450.1 - 4.7e-07 29.9 0.3 1.8e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EFX04450.1 - 8.5e-07 29.0 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX04450.1 - 2.6e-05 23.9 0.0 4.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 EFX04450.1 - 0.00023 20.9 0.2 0.03 14.1 0.0 3.0 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFX04450.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase HD PF01966.17 EFX04451.1 - 2.4e-05 24.3 0.4 0.00013 21.9 0.3 2.2 1 1 0 1 1 1 1 HD domain Porin_3 PF01459.17 EFX04452.1 - 6.2e-58 196.2 8.7 6.7e-57 192.8 6.0 2.0 1 1 0 1 1 1 1 Eukaryotic porin Aldedh PF00171.17 EFX04453.1 - 1.1e-117 393.2 0.4 1.3e-117 392.9 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EFX04453.1 - 0.00014 20.6 0.0 0.00054 18.7 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) LRR_8 PF13855.1 EFX04454.1 - 0.00021 20.9 2.9 0.53 10.0 0.0 4.2 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.2 EFX04454.1 - 0.00057 19.4 4.7 1 9.0 0.0 5.3 4 1 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EFX04454.1 - 0.00065 19.5 1.6 0.63 10.2 0.0 4.6 4 0 0 4 4 4 1 Leucine Rich repeat LRR_7 PF13504.1 EFX04454.1 - 0.24 11.7 7.8 31 5.3 0.0 6.0 7 0 0 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 EFX04454.1 - 0.35 11.0 8.0 46 4.6 0.0 6.6 6 1 2 8 8 8 0 Leucine Rich Repeat SIS_2 PF13580.1 EFX04455.1 - 0.0017 18.0 0.0 0.0031 17.2 0.0 1.4 1 0 0 1 1 1 1 SIS domain F-box-like PF12937.2 EFX04456.1 - 3.9e-06 26.4 0.1 7.8e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX04456.1 - 0.0005 19.6 0.2 0.0023 17.5 0.1 2.1 2 0 0 2 2 2 1 F-box domain Bromodomain PF00439.20 EFX04457.1 - 2.2e-31 107.6 0.9 4.4e-16 58.5 0.0 2.4 2 0 0 2 2 2 2 Bromodomain DUF4019 PF13211.1 EFX04457.1 - 0.075 13.3 0.3 0.22 11.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4019) Nop14 PF04147.7 EFX04457.1 - 0.49 8.2 12.7 0.68 7.7 8.8 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 EFX04457.1 - 1.2 8.3 11.8 1.8 7.7 8.2 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.9 EFX04457.1 - 3.7 5.4 14.1 5.5 4.8 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.20 EFX04458.1 - 1.4e-21 76.8 0.0 2.7e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.27 EFX04458.1 - 6.4e-14 51.2 14.5 1.8e-09 37.1 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat HEAT PF02985.17 EFX04458.1 - 5.4e-12 44.7 11.5 0.0034 17.3 0.0 7.1 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.1 EFX04458.1 - 5.2e-07 29.8 9.0 0.054 13.7 0.0 5.2 3 1 0 4 4 4 3 HEAT repeats Pkinase_Tyr PF07714.12 EFX04458.1 - 1.9e-05 23.8 0.0 3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_EZ PF13513.1 EFX04458.1 - 0.0013 19.1 7.7 0.095 13.2 0.3 4.6 3 1 1 4 4 4 1 HEAT-like repeat Nucleoporin_N PF08801.6 EFX04458.1 - 0.0086 14.8 0.0 3.8 6.1 0.0 3.0 3 0 0 3 3 3 1 Nup133 N terminal like Adaptin_N PF01602.15 EFX04458.1 - 0.015 13.6 0.1 0.31 9.2 0.0 2.2 2 0 0 2 2 2 0 Adaptin N terminal region RasGEF_N_2 PF14663.1 EFX04458.1 - 0.049 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Fungal_trans PF04082.13 EFX04460.1 - 5.3e-17 61.5 0.0 7.8e-17 60.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04460.1 - 1.3e-08 34.5 8.0 2.2e-08 33.8 5.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain STE2 PF02116.10 EFX04461.1 - 8.5e-37 126.7 15.0 1e-36 126.4 10.4 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR Pex19 PF04614.7 EFX04462.1 - 5.6e-70 235.8 9.1 2.7e-69 233.5 6.3 1.9 1 1 0 1 1 1 1 Pex19 protein family FliE PF02049.13 EFX04462.1 - 0.026 14.5 4.9 0.081 12.9 3.4 1.8 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE GET2 PF08690.5 EFX04462.1 - 0.21 10.7 3.5 0.075 12.2 0.5 1.6 2 0 0 2 2 2 0 GET complex subunit GET2 Acetyltransf_6 PF13480.1 EFX04462.1 - 0.4 10.6 1.9 3.7 7.4 0.0 2.9 2 1 1 3 3 3 0 Acetyltransferase (GNAT) domain PA26 PF04636.8 EFX04462.1 - 0.48 9.0 2.4 0.53 8.9 1.1 1.4 1 1 0 1 1 1 0 PA26 p53-induced protein (sestrin) MSP1_C PF07462.6 EFX04462.1 - 6.8 4.9 6.5 9.9 4.4 4.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Bud13 PF09736.4 EFX04463.1 - 1.6e-43 148.4 4.2 1.6e-43 148.4 2.9 2.5 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex FAD_binding_3 PF01494.14 EFX04464.1 - 8.2e-17 61.2 0.9 7.9e-09 35.0 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain ADC PF06314.6 EFX04464.1 - 1.9e-10 40.5 0.0 3.3e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Cupin_2 PF07883.6 EFX04464.1 - 2.1e-07 30.3 0.0 4.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Cupin domain DAO PF01266.19 EFX04464.1 - 4.3e-07 29.1 0.0 7.1e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX04464.1 - 8.4e-07 28.9 0.2 2.6e-06 27.3 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX04464.1 - 7.2e-06 25.0 1.1 1.4e-05 24.1 0.8 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EFX04464.1 - 6.8e-05 21.5 0.6 9.8e-05 20.9 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 EFX04464.1 - 7.7e-05 22.6 0.0 0.00015 21.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EFX04464.1 - 0.0014 17.8 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFX04464.1 - 0.0015 18.8 0.2 0.0069 16.7 0.2 2.1 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX04464.1 - 0.0024 16.5 0.3 0.0044 15.7 0.2 1.4 1 0 0 1 1 1 1 Tryptophan halogenase GIDA PF01134.17 EFX04464.1 - 0.0045 15.9 0.1 0.0069 15.2 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EFX04464.1 - 0.0057 15.6 0.9 0.026 13.4 0.6 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.12 EFX04464.1 - 0.016 14.3 0.1 0.03 13.3 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 EFX04464.1 - 0.029 14.4 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 EFX04464.1 - 0.032 13.6 0.6 0.078 12.4 0.4 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.1 EFX04464.1 - 0.044 13.5 0.1 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Sld5 PF05916.6 EFX04464.1 - 0.082 13.2 0.3 0.18 12.0 0.0 1.7 2 0 0 2 2 1 0 GINS complex protein Cyt-b5 PF00173.23 EFX04465.1 - 7.6e-21 73.7 0.1 8.4e-21 73.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ParA PF10609.4 EFX04466.1 - 2.7e-31 107.2 0.1 4.7e-31 106.4 0.1 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EFX04466.1 - 1e-19 70.6 0.0 1.5e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EFX04466.1 - 2e-10 40.8 0.0 3.8e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_26 PF13500.1 EFX04466.1 - 8.9e-07 28.7 0.2 0.0018 17.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.10 EFX04466.1 - 3.2e-06 26.4 0.1 8e-05 21.8 0.0 2.5 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.6 EFX04466.1 - 1.1e-05 24.7 0.0 2.1e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.13 EFX04466.1 - 2.1e-05 23.8 0.0 0.00041 19.6 0.0 2.2 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.1 EFX04466.1 - 0.00025 20.5 0.0 0.00045 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EFX04466.1 - 0.033 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_19 PF13245.1 EFX04466.1 - 0.044 13.5 3.2 1 9.1 0.1 2.8 2 0 0 2 2 2 0 Part of AAA domain YhjQ PF06564.7 EFX04466.1 - 0.049 12.9 0.3 0.089 12.1 0.1 1.5 2 0 0 2 2 2 0 YhjQ protein ArgK PF03308.11 EFX04466.1 - 0.063 12.0 1.8 0.1 11.3 0.1 1.8 2 0 0 2 2 2 0 ArgK protein SRP54 PF00448.17 EFX04466.1 - 0.091 12.1 0.4 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Lactamase_B PF00753.22 EFX04467.1 - 4.1e-05 23.3 1.1 8.6e-05 22.2 0.8 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily CLTH PF10607.4 EFX04468.1 - 9e-33 112.9 0.2 1.4e-32 112.4 0.2 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 EFX04468.1 - 2.6e-08 33.3 0.0 5.6e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 LisH Ureidogly_hydro PF04115.7 EFX04469.1 - 4e-50 169.3 0.0 1.5e-49 167.5 0.0 1.7 1 1 0 1 1 1 1 Ureidoglycolate hydrolase V_ATPase_I PF01496.14 EFX04471.1 - 2.2e-296 984.7 0.0 2.6e-296 984.5 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family ERM PF00769.14 EFX04471.1 - 0.046 13.2 2.1 0.1 12.0 0.1 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Baculo_PEP_C PF04513.7 EFX04471.1 - 0.23 11.2 2.9 3.7 7.3 0.3 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Filament PF00038.16 EFX04471.1 - 0.35 10.2 9.4 1.3 8.3 0.2 2.6 2 1 0 2 2 2 0 Intermediate filament protein Mod_r PF07200.8 EFX04471.1 - 0.71 9.7 6.5 2.6 7.9 1.4 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Prefoldin_2 PF01920.15 EFX04471.1 - 0.9 9.3 4.9 3.3 7.5 0.6 2.9 3 0 0 3 3 3 0 Prefoldin subunit DivIC PF04977.10 EFX04471.1 - 1.7 8.1 6.2 0.52 9.8 0.5 2.8 2 0 0 2 2 2 0 Septum formation initiator GAS PF13851.1 EFX04471.1 - 4.4 6.4 7.6 1.8 7.7 1.5 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding GvpK PF05121.7 EFX04471.1 - 7.6 6.4 7.2 5.8 6.8 0.7 3.0 2 1 1 3 3 3 0 Gas vesicle protein K MFS_1 PF07690.11 EFX04472.1 - 1.9e-27 95.9 38.1 1.9e-27 95.9 26.4 1.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Exo_endo_phos PF03372.18 EFX04473.1 - 5.2e-05 23.2 2.4 7.3e-05 22.8 1.6 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Jacalin PF01419.12 EFX04473.1 - 0.016 15.0 0.2 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Jacalin-like lectin domain DUF1681 PF07933.9 EFX04474.1 - 1e-57 194.1 0.3 1.3e-56 190.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1681) DUF605 PF04652.11 EFX04474.1 - 0.073 12.4 10.0 0.081 12.3 6.9 1.1 1 0 0 1 1 1 0 Vta1 like Mito_fiss_reg PF05308.6 EFX04474.1 - 0.38 10.0 10.7 0.8 9.0 7.4 1.5 1 1 0 1 1 1 0 Mitochondrial fission regulator SR-25 PF10500.4 EFX04474.1 - 7.6 5.9 13.8 14 5.1 6.2 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CAP_N PF01213.14 EFX04474.1 - 7.7 5.6 11.3 4.7 6.3 6.4 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Amastin PF07344.6 EFX04475.1 - 0.00056 19.5 3.6 0.00056 19.5 2.5 2.1 1 1 1 2 2 2 1 Amastin surface glycoprotein UPF1_Zn_bind PF09416.5 EFX04476.1 - 1.9e-72 241.8 4.2 7.1e-72 239.9 0.9 2.4 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 EFX04476.1 - 8.9e-61 204.7 0.0 3.6e-60 202.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 EFX04476.1 - 8.9e-56 189.0 1.8 1.4e-55 188.4 1.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX04476.1 - 5.9e-14 51.5 0.6 1.5e-13 50.2 0.1 1.9 2 0 0 2 2 1 1 Part of AAA domain AAA_30 PF13604.1 EFX04476.1 - 2.1e-12 47.0 0.1 2.2e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 EFX04476.1 - 1.7e-07 31.2 0.0 3.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 EFX04476.1 - 2e-05 24.2 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 EFX04476.1 - 3.8e-05 23.3 0.1 0.33 10.4 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 EFX04476.1 - 0.00033 19.7 1.0 0.0024 16.8 0.0 2.7 3 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.9 EFX04476.1 - 0.0007 18.6 0.2 0.33 9.8 0.0 2.3 1 1 0 2 2 2 2 PIF1-like helicase DEAD PF00270.24 EFX04476.1 - 0.0008 18.9 0.2 0.0022 17.4 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.16 EFX04476.1 - 0.0011 18.3 0.1 0.03 13.6 0.0 2.2 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.17 EFX04476.1 - 0.003 17.0 0.0 0.0064 15.9 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain KaiC PF06745.8 EFX04476.1 - 0.01 14.9 0.0 0.024 13.7 0.0 1.5 2 0 0 2 2 2 0 KaiC Ribosomal_S13_N PF08069.7 EFX04476.1 - 0.035 13.9 0.0 0.099 12.4 0.0 1.8 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain FtsK_SpoIIIE PF01580.13 EFX04476.1 - 0.04 13.3 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.1 EFX04476.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 EFX04476.1 - 0.087 11.7 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SNF2_N PF00176.18 EFX04476.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_22 PF13401.1 EFX04476.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EFX04476.1 - 0.14 11.4 0.0 0.34 10.0 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_5 PF07728.9 EFX04476.1 - 0.15 11.8 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 EFX04476.1 - 0.15 11.4 0.0 0.41 10.0 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain FHA PF00498.21 EFX04477.1 - 3e-12 46.4 0.0 5.1e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain DUF4588 PF15251.1 EFX04478.1 - 2.9e-05 24.1 7.9 2.9e-05 24.1 5.5 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4588) Abhydrolase_2 PF02230.11 EFX04479.1 - 9.1e-32 110.2 0.0 3.6e-24 85.4 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EFX04479.1 - 1.1e-08 35.2 0.0 1.7e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX04479.1 - 3.9e-08 33.1 0.0 5.7e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX04479.1 - 2.5e-07 30.1 0.0 5.4e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.13 EFX04479.1 - 0.00022 20.5 0.0 0.00039 19.7 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 EFX04479.1 - 0.0041 16.7 0.0 0.018 14.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2732 PF10809.3 EFX04479.1 - 0.15 11.6 0.8 0.3 10.6 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2732) Methyltransf_18 PF12847.2 EFX04480.1 - 3e-13 50.3 0.0 1.9e-12 47.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX04480.1 - 3.5e-12 46.3 0.0 5.5e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04480.1 - 2.1e-11 44.1 0.0 5.2e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04480.1 - 9.7e-10 38.7 0.0 1.9e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04480.1 - 1.4e-09 37.7 0.0 2.1e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04480.1 - 2.4e-09 37.5 0.0 5.6e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX04480.1 - 3.4e-08 33.5 0.7 3.4e-08 33.5 0.5 1.9 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 EFX04480.1 - 0.00081 19.4 0.0 0.0018 18.3 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.1 EFX04480.1 - 0.0012 18.5 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX04480.1 - 0.0047 16.3 0.0 0.0076 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 EFX04480.1 - 0.028 13.9 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.15 EFX04480.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.15 EFX04480.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase HCO3_cotransp PF00955.16 EFX04482.1 - 3.1e-66 224.0 11.5 1.8e-42 145.6 1.0 3.1 1 1 2 3 3 3 3 HCO3- transporter family CTD_bind PF04818.8 EFX04483.1 - 0.0012 19.0 0.0 0.0023 18.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Spt20 PF12090.3 EFX04483.1 - 1.1 8.5 8.8 0.51 9.6 0.1 2.6 3 0 0 3 3 3 0 Spt20 family LMBR1 PF04791.11 EFX04485.1 - 8.5e-13 47.6 9.9 1.2e-12 47.2 0.0 2.4 1 1 1 2 2 2 2 LMBR1-like membrane protein CBFB_NFYA PF02045.10 EFX04486.1 - 5.5e-30 103.6 4.3 1.1e-29 102.6 3.0 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B SprT-like PF10263.4 EFX04487.1 - 1.9e-50 170.5 2.5 2.8e-50 170.0 1.8 1.3 1 0 0 1 1 1 1 SprT-like family HMG_box PF00505.14 EFX04487.1 - 5.5e-06 26.5 0.2 5.5e-06 26.5 0.1 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFX04487.1 - 9.8e-05 22.6 0.1 0.00026 21.2 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain Zn-ribbon_8 PF09723.5 EFX04487.1 - 0.013 15.4 1.8 0.029 14.3 1.2 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Peptidase_MA_2 PF13485.1 EFX04487.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase MA superfamily Nop14 PF04147.7 EFX04487.1 - 0.16 9.8 26.2 0.29 9.0 18.2 1.3 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 EFX04487.1 - 1.8 6.9 30.6 0.43 9.0 18.4 1.8 1 1 1 2 2 2 0 Daxx Family NAD_binding_10 PF13460.1 EFX04488.1 - 9.6e-10 38.7 0.1 3.1e-08 33.8 0.1 2.9 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFX04488.1 - 0.00038 19.9 0.0 0.0058 16.0 0.0 2.5 2 1 0 3 3 3 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EFX04488.1 - 0.011 14.3 0.0 0.08 11.6 0.0 2.1 2 1 1 3 3 3 0 3-beta hydroxysteroid dehydrogenase/isomerase family CBM_1 PF00734.13 EFX04488.1 - 0.14 11.8 0.3 0.23 11.1 0.2 1.3 1 0 0 1 1 1 0 Fungal cellulose binding domain Glyco_hydro_3 PF00933.16 EFX04489.1 - 5.5e-88 294.7 0.0 7.9e-88 294.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX04489.1 - 3e-42 144.6 0.0 2.8e-41 141.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX04489.1 - 1e-22 79.8 0.1 2e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain 2OG-FeII_Oxy_3 PF13640.1 EFX04490.1 - 0.011 16.2 0.0 0.057 13.9 0.0 2.3 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily HSP70 PF00012.15 EFX04491.1 - 3.4e-07 28.5 0.0 0.0014 16.6 0.1 3.0 3 0 0 3 3 3 3 Hsp70 protein VHS PF00790.14 EFX04493.1 - 4.1e-44 149.6 0.0 1.2e-43 148.1 0.0 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.9 EFX04493.1 - 4.5e-23 81.1 0.3 1.1e-22 79.8 0.2 1.6 1 0 0 1 1 1 1 GAT domain Alpha_adaptinC2 PF02883.15 EFX04493.1 - 6.1e-18 65.2 0.0 1.1e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Cellulase PF00150.13 EFX04494.1 - 1.6e-16 60.3 0.0 2.1e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) cobW PF02492.14 EFX04495.1 - 5e-34 117.2 0.0 7.5e-34 116.7 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 EFX04495.1 - 0.003 17.2 0.0 0.0057 16.3 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 EFX04495.1 - 0.028 14.1 0.6 0.11 12.2 0.1 2.2 2 0 0 2 2 2 0 Part of AAA domain DUF463 PF04317.7 EFX04495.1 - 0.03 12.8 0.0 0.047 12.2 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_10 PF12846.2 EFX04495.1 - 0.046 13.1 0.0 0.15 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 EFX04495.1 - 0.047 13.8 0.0 1 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EFX04495.1 - 0.076 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.1 EFX04495.1 - 0.084 12.4 0.1 0.85 9.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.10 EFX04496.1 - 5.6e-55 187.0 0.0 1e-54 186.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.24 EFX04496.1 - 0.00048 20.3 0.0 0.0021 18.2 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EFX04496.1 - 0.0006 19.5 0.2 0.0016 18.1 0.2 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 EFX04496.1 - 0.001 19.2 0.0 0.0037 17.3 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFX04496.1 - 0.0013 18.7 0.2 0.02 14.8 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EFX04496.1 - 0.0048 17.7 0.0 0.013 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EFX04496.1 - 0.0064 16.0 0.1 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 EFX04496.1 - 0.0075 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF853 PF05872.7 EFX04496.1 - 0.0094 14.3 1.7 0.023 13.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) AAA_18 PF13238.1 EFX04496.1 - 0.013 15.8 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFX04496.1 - 0.035 13.7 0.3 0.11 12.1 0.2 1.9 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.13 EFX04496.1 - 0.057 12.9 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.1 EFX04496.1 - 0.12 12.3 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain CBM_20 PF00686.14 EFX04497.1 - 0.025 14.1 0.1 0.061 12.9 0.1 1.6 1 0 0 1 1 1 0 Starch binding domain Macoilin PF09726.4 EFX04497.1 - 0.12 10.5 9.8 0.15 10.3 6.8 1.1 1 0 0 1 1 1 0 Transmembrane protein Apt1 PF10351.4 EFX04497.1 - 4.8 5.9 12.0 0.67 8.7 5.7 1.5 2 0 0 2 2 2 0 Golgi-body localisation protein domain Bd3614_N PF14442.1 EFX04498.1 - 0.045 13.7 0.0 0.19 11.7 0.0 2.0 2 1 0 2 2 2 0 Bd3614-like deaminase N-terminal Carb_anhydrase PF00194.16 EFX04499.1 - 6.5e-20 71.1 0.0 5e-09 35.4 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic-type carbonic anhydrase CAP_N PF01213.14 EFX04500.1 - 7.9e-94 314.4 16.0 1.2e-92 310.5 11.1 2.2 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 EFX04500.1 - 1.6e-47 160.7 0.0 2.3e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Polysacc_deac_1 PF01522.16 EFX04501.1 - 4.4e-21 74.8 0.0 8.7e-21 73.8 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase AP_endonuc_2 PF01261.19 EFX04501.1 - 0.098 11.9 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Methyltransf_16 PF10294.4 EFX04502.1 - 5.7e-11 42.1 0.0 2.8e-09 36.6 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.2 EFX04502.1 - 0.075 13.6 0.0 0.47 11.0 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain BRF1 PF07741.8 EFX04502.1 - 0.25 11.6 3.1 0.12 12.5 0.6 1.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Ammonium_transp PF00909.16 EFX04503.1 - 1.7e-116 389.0 32.8 1.9e-116 388.8 22.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Ribosomal_S13 PF00416.17 EFX04505.1 - 4.7e-23 81.6 0.0 5.2e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 APH PF01636.18 EFX04506.1 - 0.00011 22.0 0.0 0.00014 21.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family HEAT PF02985.17 EFX04507.1 - 1.5e-45 149.2 16.6 0.0029 17.5 0.1 13.2 14 0 0 14 14 14 12 HEAT repeat HEAT_2 PF13646.1 EFX04507.1 - 4.5e-30 103.7 4.1 2.7e-08 33.9 0.0 7.7 3 3 3 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.2 EFX04507.1 - 6.1e-13 48.9 3.6 0.00059 20.1 0.1 7.7 5 2 4 9 9 9 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 EFX04507.1 - 4.1e-08 33.4 15.8 0.12 12.8 0.0 9.2 8 3 4 12 12 12 2 HEAT-like repeat Adaptin_N PF01602.15 EFX04507.1 - 9.3e-06 24.2 10.6 0.031 12.6 0.0 5.2 3 2 2 5 5 5 2 Adaptin N terminal region CLASP_N PF12348.3 EFX04507.1 - 2.6e-05 23.6 2.1 0.017 14.5 0.1 4.3 5 2 1 6 6 6 1 CLASP N terminal RIX1 PF08167.7 EFX04507.1 - 0.0013 18.4 0.1 0.055 13.1 0.0 3.4 2 1 2 4 4 4 1 rRNA processing/ribosome biogenesis DUF2435 PF10363.4 EFX04507.1 - 0.0018 18.1 3.5 1.4 8.8 0.1 4.5 3 1 1 4 4 4 1 Protein of unknown function (DUF2435) Cnd1 PF12717.2 EFX04507.1 - 0.018 14.8 6.2 5.7 6.7 0.1 5.1 3 1 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EFX04507.1 - 0.049 13.4 7.0 1.9 8.4 0.0 5.2 7 0 0 7 7 6 0 Armadillo/beta-catenin-like repeat Cnd3 PF12719.2 EFX04507.1 - 0.061 12.2 0.4 0.51 9.2 0.2 2.3 2 1 1 3 3 3 0 Nuclear condensing complex subunits, C-term domain FIST PF08495.5 EFX04507.1 - 0.074 12.1 0.0 1.4 8.0 0.0 2.4 2 0 0 2 2 2 0 FIST N domain Proteasom_PSMB PF10508.4 EFX04507.1 - 0.1 10.8 3.4 0.6 8.3 0.1 2.9 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit ATP_bind_1 PF03029.12 EFX04508.1 - 8.2e-71 238.3 0.0 8.9e-70 234.9 0.0 1.9 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 EFX04508.1 - 9.3e-05 23.2 0.0 0.00024 21.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFX04508.1 - 0.0025 17.7 0.0 0.0046 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EFX04508.1 - 0.0031 16.9 0.4 0.0094 15.4 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.17 EFX04508.1 - 0.0046 17.1 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.1 EFX04508.1 - 0.0085 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 EFX04508.1 - 0.021 14.5 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EFX04508.1 - 0.033 14.3 0.0 0.069 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EFX04508.1 - 0.042 13.4 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFX04508.1 - 0.049 13.0 0.0 0.16 11.4 0.0 1.7 1 1 1 2 2 2 0 AAA-like domain AAA_31 PF13614.1 EFX04508.1 - 0.052 13.4 0.1 0.25 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 EFX04508.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase Septin PF00735.13 EFX04508.1 - 0.064 12.2 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Septin ABC_tran PF00005.22 EFX04508.1 - 0.076 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.22 EFX04508.1 - 0.1 12.0 0.0 3 7.2 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRP54 PF00448.17 EFX04508.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.1 EFX04508.1 - 0.13 12.2 0.0 0.34 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain ArgK PF03308.11 EFX04508.1 - 0.14 10.8 0.0 0.74 8.5 0.0 2.0 2 0 0 2 2 2 0 ArgK protein FtsK_SpoIIIE PF01580.13 EFX04508.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.1 EFX04508.1 - 0.15 12.3 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain HAD_2 PF13419.1 EFX04510.1 - 1.8e-14 54.3 0.0 2.1e-13 50.8 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX04510.1 - 0.0016 18.0 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Pkr1 PF08636.5 EFX04511.1 - 1.2e-33 114.9 6.6 1.7e-33 114.4 4.6 1.2 1 0 0 1 1 1 1 ER protein Pkr1 LSM PF01423.17 EFX04511.1 - 1.7e-15 56.3 0.0 2.7e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EFX04511.1 - 0.00053 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain Pdase_C33_assoc PF14756.1 EFX04511.1 - 0.02 14.5 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase_C33-associated domain DUF2763 PF10961.3 EFX04511.1 - 1.1 9.7 6.8 3.6 8.0 4.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) Dioxygenase_C PF00775.16 EFX04512.1 - 2.4e-11 43.2 1.9 1.9e-10 40.3 1.3 2.2 1 1 0 1 1 1 1 Dioxygenase Cyt-b5 PF00173.23 EFX04513.1 - 2.3e-15 56.1 0.0 2.8e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-B_box PF00643.19 EFX04514.1 - 0.014 15.3 0.5 0.022 14.6 0.3 1.3 1 0 0 1 1 1 0 B-box zinc finger zf-HIT PF04438.11 EFX04514.1 - 0.74 9.5 4.7 1.1 8.9 3.2 1.2 1 0 0 1 1 1 0 HIT zinc finger SUN PF03856.8 EFX04515.1 - 1.4e-73 247.2 13.0 1.9e-73 246.8 9.0 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) CDC27 PF09507.5 EFX04516.1 - 1.3e-49 169.6 34.7 5.5e-48 164.2 24.1 2.8 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 MSP1_C PF07462.6 EFX04516.1 - 0.52 8.6 4.6 0.85 7.9 3.2 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus KOW PF00467.24 EFX04517.1 - 4.7e-07 29.2 1.5 1.2e-06 27.9 1.0 1.7 1 0 0 1 1 1 1 KOW motif DUF1442 PF07279.6 EFX04517.1 - 0.075 12.1 0.3 0.1 11.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) RRM_1 PF00076.17 EFX04518.1 - 7.5e-20 70.3 0.0 8.1e-11 41.4 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX04518.1 - 2.1e-14 53.2 0.0 8.8e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX04518.1 - 7.1e-13 48.1 0.0 2.1e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.10 EFX04518.1 - 0.081 12.6 0.0 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Reo_sigmaC PF04582.7 EFX04519.1 - 0.0085 15.3 1.4 0.19 10.8 0.1 2.5 2 1 1 3 3 3 2 Reovirus sigma C capsid protein MAM33 PF02330.11 EFX04520.1 - 7.6e-34 117.2 0.4 1.1e-33 116.7 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial glycoprotein RIC1 PF07064.8 EFX04522.1 - 1.4e-82 277.0 0.0 2e-82 276.5 0.0 1.2 1 0 0 1 1 1 1 RIC1 ENTH PF01417.15 EFX04523.1 - 6.8e-47 158.4 0.1 1e-46 157.8 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 EFX04523.1 - 0.00028 19.6 0.1 0.00038 19.2 0.0 1.1 1 0 0 1 1 1 1 ANTH domain DDHD PF02862.12 EFX04523.1 - 0.072 12.8 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 DDHD domain BAR PF03114.13 EFX04523.1 - 0.39 10.1 2.5 11 5.4 0.2 2.1 2 0 0 2 2 2 0 BAR domain PAT1 PF09770.4 EFX04523.1 - 3.8 5.6 6.8 5.3 5.1 4.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cwf_Cwc_15 PF04889.7 EFX04524.1 - 0.047 13.4 1.9 0.072 12.7 1.3 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Collagen PF01391.13 EFX04525.1 - 7.3e-22 76.6 190.4 2.9e-08 33.1 16.0 10.7 3 3 5 8 8 8 5 Collagen triple helix repeat (20 copies) Toxin_17 PF08086.6 EFX04525.1 - 0.029 14.4 0.2 0.12 12.5 0.1 2.1 1 0 0 1 1 1 0 Ergtoxin family Fungal_trans_2 PF11951.3 EFX04526.1 - 2e-41 141.8 0.3 3e-41 141.3 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ring_hydroxyl_A PF00848.14 EFX04526.1 - 4.1e-29 101.7 1.4 2.8e-28 99.0 1.0 2.3 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Zn_clus PF00172.13 EFX04526.1 - 8.6e-07 28.7 10.9 1.5e-06 27.9 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OPT PF03169.10 EFX04527.1 - 6.5e-145 484.0 38.1 7.4e-145 483.8 26.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein P5-ATPase PF12409.3 EFX04527.1 - 0.08 12.8 4.7 0.69 9.7 0.0 3.5 3 0 0 3 3 3 0 P5-type ATPase cation transporter DUF1212 PF06738.7 EFX04527.1 - 0.33 10.3 4.4 0.18 11.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1212) EI24 PF07264.6 EFX04529.1 - 6.2e-07 29.0 1.1 6.2e-07 29.0 0.8 2.2 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) Tcp11 PF05794.8 EFX04530.1 - 1.1e-85 288.0 2.6 3.6e-79 266.5 0.2 2.5 3 0 0 3 3 3 2 T-complex protein 11 PAT1 PF09770.4 EFX04530.1 - 0.47 8.6 38.2 0.79 7.8 26.5 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 EFX04530.1 - 0.91 9.3 23.0 1.7 8.4 15.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Baculo_PP31 PF05311.6 EFX04530.1 - 1.9 7.6 8.4 3.3 6.9 5.8 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SNF2_N PF00176.18 EFX04531.1 - 3.9e-62 209.7 0.2 6.4e-62 209.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX04531.1 - 8.3e-13 48.0 0.0 2.3e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX04531.1 - 1.3e-06 28.3 0.1 5.8e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EFX04531.1 - 5.5e-05 22.7 0.1 0.00012 21.5 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.20 EFX04531.1 - 6.1e-05 22.5 14.4 6.1e-05 22.5 10.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX04531.1 - 0.0012 18.5 13.1 0.0012 18.5 9.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFX04531.1 - 0.0061 16.5 13.0 0.0061 16.5 9.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) HypA PF01155.14 EFX04531.1 - 0.49 10.0 5.8 2.9 7.6 0.6 2.5 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family tRNA-synt_1 PF00133.17 EFX04532.1 - 3.6e-44 150.7 0.0 6.6e-25 87.1 0.0 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 EFX04532.1 - 4.9e-40 136.8 0.0 8.5e-40 136.0 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 EFX04532.1 - 6.8e-28 97.4 0.0 5.6e-22 77.9 0.0 3.8 3 1 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EFX04532.1 - 8.7e-14 51.5 0.0 1.8e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1d PF00750.14 EFX04532.1 - 0.0065 15.3 0.0 0.011 14.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) tRNA-synt_1e PF01406.14 EFX04532.1 - 0.2 10.7 0.0 6.9 5.6 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Sulf_transp PF04143.9 EFX04533.1 - 3e-09 36.7 32.2 1.3e-06 28.2 10.5 5.1 4 1 1 5 5 5 2 Sulphur transport MCM PF00493.18 EFX04534.1 - 5.1e-86 288.4 0.4 6.1e-42 143.5 0.0 2.1 1 1 1 2 2 2 2 MCM2/3/5 family MCM_N PF14551.1 EFX04534.1 - 2.2e-26 92.7 0.0 5.4e-26 91.4 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain AAA_32 PF13654.1 EFX04534.1 - 0.017 13.8 1.0 0.026 13.1 0.7 1.2 1 0 0 1 1 1 0 AAA domain Elf1 PF05129.8 EFX04534.1 - 0.14 11.8 2.1 0.19 11.4 0.7 1.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Zn-ribbon_8 PF09723.5 EFX04534.1 - 0.21 11.5 0.6 0.44 10.5 0.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Serinc PF03348.10 EFX04535.1 - 6e-170 565.6 5.8 6.7e-170 565.4 4.0 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) FTR1 PF03239.9 EFX04535.1 - 5.6 5.8 13.2 0.77 8.6 6.0 1.8 2 0 0 2 2 2 0 Iron permease FTR1 family Methyltransf_23 PF13489.1 EFX04536.1 - 4.2e-20 72.0 0.0 5.8e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04536.1 - 5.9e-15 55.5 0.0 2.1e-14 53.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04536.1 - 1.6e-14 53.7 0.0 1.9e-13 50.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04536.1 - 1.3e-13 51.2 0.0 2.1e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04536.1 - 7.7e-13 49.0 0.0 1.8e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX04536.1 - 1.1e-06 27.9 0.0 1.9e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFX04536.1 - 8.3e-06 25.8 0.2 2.7e-05 24.1 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04536.1 - 1e-05 25.8 0.0 3.7e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.6 EFX04536.1 - 3.6e-05 23.2 0.0 0.00047 19.6 0.1 2.0 2 0 0 2 2 2 1 Nodulation protein S (NodS) DREV PF05219.7 EFX04536.1 - 0.00021 20.2 0.0 0.022 13.6 0.0 2.1 2 0 0 2 2 2 1 DREV methyltransferase RrnaAD PF00398.15 EFX04536.1 - 0.00029 19.9 0.0 0.00043 19.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 EFX04536.1 - 0.0019 17.6 0.1 0.0039 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 EFX04536.1 - 0.0038 16.7 0.0 0.0069 15.9 0.0 1.4 2 0 0 2 2 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.4 EFX04536.1 - 0.011 15.2 0.0 0.029 13.8 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_4 PF02390.12 EFX04536.1 - 0.035 13.1 0.0 0.3 10.1 0.0 2.1 2 1 1 3 3 3 0 Putative methyltransferase Methyltransf_32 PF13679.1 EFX04536.1 - 0.036 13.7 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.6 EFX04536.1 - 0.067 11.8 0.0 0.38 9.4 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) tRNA_U5-meth_tr PF05958.6 EFX04536.1 - 0.084 11.5 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase DUF938 PF06080.7 EFX04536.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Pox_MCEL PF03291.11 EFX04536.1 - 0.21 10.4 0.0 0.48 9.2 0.0 1.5 1 1 0 1 1 1 0 mRNA capping enzyme Tannase PF07519.6 EFX04537.1 - 2.1e-91 307.0 0.0 3.8e-91 306.1 0.0 1.3 1 1 0 1 1 1 1 Tannase and feruloyl esterase Esterase PF00756.15 EFX04537.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase ATP_bind_3 PF01171.15 EFX04538.1 - 1.6e-18 66.8 0.0 2.7e-18 66.0 0.0 1.4 1 1 0 1 1 1 1 PP-loop family RecR PF02132.10 EFX04538.1 - 0.0011 18.3 2.3 0.0016 17.7 0.3 2.3 2 0 0 2 2 2 1 RecR protein DUF2392 PF10288.4 EFX04538.1 - 0.0022 18.3 0.0 0.0051 17.1 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2392) tRNA_Me_trans PF03054.11 EFX04538.1 - 0.0086 14.6 0.0 0.014 13.9 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase CoA_transf_3 PF02515.12 EFX04539.1 - 9.3e-32 109.8 0.0 5.3e-30 104.0 0.0 2.5 2 1 0 2 2 2 2 CoA-transferase family III DNA_ligase_A_C PF04679.10 EFX04539.1 - 0.028 14.7 0.0 0.26 11.7 0.0 2.2 2 0 0 2 2 2 0 ATP dependent DNA ligase C terminal region Maf1 PF09174.5 EFX04540.1 - 4.2e-58 196.1 0.0 6.3e-58 195.5 0.0 1.3 1 0 0 1 1 1 1 Maf1 regulator SURF2 PF05477.6 EFX04540.1 - 0.59 9.2 8.4 0.86 8.6 5.8 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) adh_short_C2 PF13561.1 EFX04541.1 - 7.5e-09 35.7 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX04541.1 - 2e-07 31.0 0.7 2e-07 31.0 0.5 2.9 2 1 1 3 3 3 1 short chain dehydrogenase KR PF08659.5 EFX04541.1 - 0.013 15.1 2.5 0.087 12.4 0.2 2.8 2 1 1 3 3 3 0 KR domain Kinesin PF00225.18 EFX04542.1 - 4.4e-112 374.0 0.0 6.5e-112 373.5 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Gly_transf_sug PF04488.10 EFX04543.1 - 1.9e-14 53.8 0.0 9.9e-14 51.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EFX04543.1 - 0.011 14.3 0.1 0.031 12.7 0.0 1.7 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.7 EFX04543.1 - 0.11 11.6 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Glyco_hydro_3 PF00933.16 EFX04545.1 - 4.4e-60 203.1 0.0 3.5e-40 137.8 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX04545.1 - 3.9e-53 180.2 0.3 1.5e-52 178.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX04545.1 - 2.8e-20 72.0 0.1 5.5e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain MGC-24 PF05283.6 EFX04545.1 - 0.037 13.8 2.9 0.11 12.2 2.0 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Aldedh PF00171.17 EFX04546.1 - 3.5e-135 450.9 0.9 5.1e-135 450.3 0.6 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EFX04546.1 - 0.09 11.4 0.0 0.15 10.7 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Glyco_hydro_16 PF00722.16 EFX04547.1 - 1.3e-08 34.3 2.2 8.5e-08 31.6 1.5 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Metallophos_2 PF12850.2 EFX04548.1 - 4.1e-09 36.4 0.1 7e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EFX04548.1 - 0.00022 20.7 0.1 0.0032 16.8 0.1 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PLDc_2 PF13091.1 EFX04549.1 - 1.2e-11 44.4 0.0 0.00014 21.6 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 EFX04549.1 - 1.4e-07 31.0 1.7 0.0079 15.9 0.0 3.4 3 0 0 3 3 3 3 Phospholipase D Active site motif ENTH PF01417.15 EFX04550.1 - 2.2e-49 166.4 0.0 4.1e-49 165.6 0.0 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 EFX04550.1 - 0.0082 14.8 0.0 0.012 14.2 0.0 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.14 EFX04550.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 VHS domain DUF1510 PF07423.6 EFX04550.1 - 0.028 13.7 8.8 0.2 10.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) UIM PF02809.15 EFX04550.1 - 0.13 11.8 1.4 0.83 9.3 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin interaction motif ACT_7 PF13840.1 EFX04551.1 - 5.8e-21 73.7 0.2 7.7e-15 54.1 0.0 2.4 2 0 0 2 2 2 2 ACT domain LpxD PF04613.9 EFX04551.1 - 0.014 14.9 0.0 0.062 12.8 0.0 2.1 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD adh_short PF00106.20 EFX04552.1 - 3.2e-15 56.4 0.3 5e-15 55.8 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX04552.1 - 0.00017 21.3 0.2 0.00031 20.4 0.1 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 EFX04552.1 - 0.044 13.0 0.4 0.25 10.5 0.2 2.0 2 0 0 2 2 2 0 NmrA-like family DUF460 PF04312.8 EFX04552.1 - 0.056 12.9 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF460) ATE_C PF04377.10 EFX04553.1 - 8.6e-41 138.9 0.0 1.3e-40 138.4 0.0 1.3 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 EFX04553.1 - 0.026 14.3 0.2 0.058 13.2 0.2 1.6 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.1 EFX04553.1 - 0.036 14.0 0.1 0.09 12.7 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GATA PF00320.22 EFX04554.1 - 0.00027 20.1 5.7 0.012 14.8 1.4 2.6 2 0 0 2 2 2 2 GATA zinc finger Svf1 PF08622.5 EFX04556.1 - 1.3e-125 418.7 0.0 1.7e-125 418.3 0.0 1.1 1 0 0 1 1 1 1 Svf1-like SRR PF07709.6 EFX04557.1 - 0.12 12.6 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 Seven Residue Repeat CTP_transf_1 PF01148.15 EFX04558.1 - 6.7e-09 35.7 7.1 2.7e-05 23.9 0.4 2.7 2 0 0 2 2 2 2 Cytidylyltransferase family Sugar_tr PF00083.19 EFX04559.1 - 5.3e-109 364.7 24.4 6.2e-109 364.5 16.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04559.1 - 1.4e-18 66.8 43.3 1.9e-12 46.5 9.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SNF2_N PF00176.18 EFX04560.1 - 0.009 14.8 0.0 0.015 14.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 EFX04560.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Sugar_tr PF00083.19 EFX04561.1 - 3.3e-59 200.6 9.2 4.3e-59 200.2 6.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04561.1 - 6.5e-17 61.2 18.3 8e-17 60.9 12.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily SUI1 PF01253.17 EFX04562.1 - 1.7e-23 82.2 0.7 3.5e-23 81.2 0.5 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 TnpV PF14198.1 EFX04562.1 - 0.025 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Transposon-encoded protein TnpV FYRC PF05965.9 EFX04562.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 F/Y rich C-terminus TPR_12 PF13424.1 EFX04566.1 - 1.1e-09 38.0 2.5 0.0047 16.8 0.6 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 EFX04566.1 - 2.1e-06 27.0 1.6 0.22 11.4 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX04566.1 - 3.8e-05 23.2 3.7 0.12 12.0 0.1 3.8 3 0 0 3 3 3 2 TPR repeat TPR_1 PF00515.23 EFX04566.1 - 0.00012 21.5 2.8 0.12 12.0 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX04566.1 - 0.0099 15.7 9.7 1.5 8.9 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.9 EFX04566.1 - 0.04 14.3 0.1 0.04 14.3 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3754 PF12576.3 EFX04566.1 - 0.067 12.8 0.6 0.12 12.0 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) TPR_10 PF13374.1 EFX04566.1 - 0.073 13.0 1.0 3 7.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX04566.1 - 0.36 11.3 2.1 10 6.8 0.1 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat DASH_Dad4 PF08650.5 EFX04567.1 - 3.5e-23 81.2 5.0 5.8e-23 80.5 3.5 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad4 GST_C_3 PF14497.1 EFX04567.1 - 5.2e-06 26.8 0.1 1.4e-05 25.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFX04567.1 - 0.012 15.5 4.0 0.028 14.3 2.8 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF2731 PF10806.3 EFX04567.1 - 0.079 13.2 0.1 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2731) Tctex-1 PF03645.8 EFX04569.1 - 7.3e-36 122.0 0.0 8.6e-36 121.8 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family TauD PF02668.11 EFX04570.1 - 1.8e-33 116.2 0.1 2.9e-33 115.6 0.1 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ribosomal_S3_C PF00189.15 EFX04571.1 - 1.3e-16 60.5 0.1 2.6e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 EFX04571.1 - 2.7e-12 46.0 0.1 4.7e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.3 EFX04571.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Mito_carr PF00153.22 EFX04572.1 - 2e-61 203.7 1.4 2.1e-25 88.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Nop PF01798.13 EFX04573.1 - 1.7e-40 137.7 0.1 2.9e-40 137.0 0.1 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 EFX04573.1 - 1.8e-39 134.9 0.3 4.4e-39 133.7 0.1 1.7 2 0 0 2 2 2 1 Prp31 C terminal domain NOSIC PF08060.8 EFX04573.1 - 2.3e-19 68.9 0.1 6.4e-19 67.5 0.0 1.8 2 0 0 2 2 2 1 NOSIC (NUC001) domain UEV PF05743.8 EFX04575.1 - 6.7e-38 129.0 0.1 9e-38 128.6 0.0 1.2 1 0 0 1 1 1 1 UEV domain UQ_con PF00179.21 EFX04575.1 - 0.0048 16.3 0.1 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ADH_N PF08240.7 EFX04577.1 - 5.5e-28 96.9 2.6 9.1e-28 96.1 1.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX04577.1 - 2.8e-14 52.8 0.2 5.3e-14 51.8 0.1 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX04577.1 - 0.00037 21.3 0.1 0.00069 20.5 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 EFX04577.1 - 0.0022 18.0 0.1 0.0037 17.2 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.16 EFX04577.1 - 0.12 11.9 0.2 0.19 11.2 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TPK_catalytic PF04263.11 EFX04578.1 - 2e-25 88.7 0.0 3e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 EFX04578.1 - 2.2e-22 78.5 0.0 3.3e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TRAPPC9-Trs120 PF08626.6 EFX04579.1 - 1.9e-116 389.8 0.0 2.4e-115 386.2 0.0 2.6 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Abhydrolase_3 PF07859.8 EFX04579.1 - 2.6e-42 144.7 0.0 2.2e-41 141.7 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.23 EFX04579.1 - 1.1e-05 24.3 0.1 2.8e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 Carboxylesterase family TFIIF_beta PF02270.10 EFX04580.1 - 3.5e-66 223.8 0.1 4.5e-66 223.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit Amidohydro_2 PF04909.9 EFX04581.1 - 2.6e-13 50.1 0.0 7.6e-13 48.6 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 EFX04581.1 - 4.6e-07 30.1 0.1 6.4e-07 29.6 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EFX04581.1 - 0.0012 18.5 0.2 0.0015 18.2 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase family CoA_binding_2 PF13380.1 EFX04581.1 - 0.014 15.5 0.1 0.11 12.7 0.0 2.3 2 1 1 3 3 3 0 CoA binding domain COQ7 PF03232.8 EFX04582.1 - 4.4e-65 218.3 0.0 5.1e-65 218.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.12 EFX04582.1 - 0.00031 21.0 0.0 0.00043 20.6 0.0 1.3 1 1 0 1 1 1 1 Rubrerythrin Imm6 PF14434.1 EFX04582.1 - 0.047 13.4 0.0 0.39 10.4 0.0 2.1 2 0 0 2 2 2 0 Immunity protein Imm6 Ferritin_2 PF13668.1 EFX04582.1 - 0.095 12.6 0.2 0.2 11.6 0.0 1.7 2 1 0 2 2 2 0 Ferritin-like domain DUF1974 PF09317.6 EFX04582.1 - 0.13 11.6 0.1 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) Beta-lactamase PF00144.19 EFX04583.1 - 3.4e-28 98.6 4.7 2e-19 69.7 0.1 2.6 2 1 0 2 2 2 2 Beta-lactamase YfcL PF08891.6 EFX04584.1 - 0.0021 17.9 0.0 0.0051 16.7 0.0 1.6 1 0 0 1 1 1 1 YfcL protein CMV_1a PF12467.3 EFX04584.1 - 3.9 7.8 14.3 0.058 13.7 0.8 2.5 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family DNA_pol_A_exo1 PF01612.15 EFX04585.1 - 3.3e-10 39.7 0.0 6.6e-10 38.7 0.0 1.4 1 1 0 1 1 1 1 3'-5' exonuclease Glyco_hydro_3 PF00933.16 EFX04586.1 - 2.8e-86 289.1 0.0 4.3e-86 288.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX04586.1 - 1.4e-52 178.4 0.3 2.1e-52 177.8 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX04586.1 - 7.7e-21 73.8 0.0 1.4e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain TPR_12 PF13424.1 EFX04587.1 - 3.7e-10 39.6 1.6 0.5 10.3 0.0 6.4 6 1 0 6 6 6 3 Tetratricopeptide repeat Suf PF05843.9 EFX04587.1 - 1.1e-08 35.2 3.3 0.2 11.3 0.0 6.0 4 1 2 7 7 7 2 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EFX04587.1 - 3.5e-06 27.1 39.3 0.24 12.1 0.0 11.8 14 1 1 15 15 12 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFX04587.1 - 9.1e-05 22.0 3.8 6.4 6.4 0.0 6.0 7 0 0 7 7 5 1 TPR repeat TPR_19 PF14559.1 EFX04587.1 - 0.00027 21.2 9.7 0.85 10.0 0.0 6.2 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX04587.1 - 0.00072 19.2 11.1 1.3 9.1 0.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 EFX04587.1 - 0.0047 16.7 13.2 0.72 9.6 0.0 6.8 7 1 1 9 9 9 1 Mad3/BUB1 homology region 1 TPR_16 PF13432.1 EFX04587.1 - 0.0047 17.5 0.1 0.0047 17.5 0.1 7.7 9 0 0 9 9 8 1 Tetratricopeptide repeat NRDE-2 PF08424.5 EFX04587.1 - 0.0064 15.4 8.9 0.015 14.1 0.5 5.1 3 2 2 5 5 5 1 NRDE-2, necessary for RNA interference TPR_8 PF13181.1 EFX04587.1 - 0.0069 16.0 0.1 4.9 7.1 0.0 4.2 5 0 0 5 5 4 1 Tetratricopeptide repeat PPR_3 PF13812.1 EFX04587.1 - 0.021 15.0 0.1 0.49 10.7 0.0 3.5 2 0 0 2 2 2 0 Pentatricopeptide repeat domain TPR_7 PF13176.1 EFX04587.1 - 0.031 14.0 10.5 6.7 6.7 0.0 6.5 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX04587.1 - 0.059 13.8 3.1 47 4.7 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Med3 PF11593.3 EFX04587.1 - 3.8 6.6 6.9 5.6 6.0 4.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TPR_10 PF13374.1 EFX04587.1 - 9 6.3 8.4 20 5.2 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Amidase PF01425.16 EFX04588.1 - 1.6e-87 294.1 0.4 4.5e-72 243.3 1.3 2.1 1 1 1 2 2 2 2 Amidase MOZ_SAS PF01853.13 EFX04589.1 - 7.6e-80 266.6 0.1 1.1e-79 266.0 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.24 EFX04589.1 - 0.042 13.5 13.9 0.011 15.3 6.6 2.2 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.1 EFX04589.1 - 0.63 9.3 4.8 1.9 7.8 3.4 1.9 1 0 0 1 1 1 0 PHD-finger Complex1_49kDa PF00346.14 EFX04590.1 - 8.8e-134 444.6 0.0 1.1e-133 444.3 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.14 EFX04590.1 - 0.2 10.3 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase adh_short PF00106.20 EFX04591.1 - 1.8e-24 86.5 0.7 2.7e-24 85.9 0.5 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04591.1 - 4.1e-18 66.0 0.0 4.8e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N PF00107.21 EFX04591.1 - 0.0067 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF1776 PF08643.5 EFX04591.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Sugar_tr PF00083.19 EFX04592.1 - 1.2e-26 93.3 20.6 4e-17 61.9 7.9 4.6 1 1 1 2 2 2 2 Sugar (and other) transporter Fructosamin_kin PF03881.9 EFX04593.1 - 1.2e-73 247.6 0.0 1.4e-73 247.4 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 EFX04593.1 - 0.0001 22.1 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YEATS PF03366.11 EFX04594.1 - 2.7e-29 100.6 0.1 4e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 YEATS family GDA1_CD39 PF01150.12 EFX04595.1 - 9.2e-97 324.2 0.0 1.4e-96 323.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family HAP1_N PF04849.8 EFX04595.1 - 0.028 13.3 2.9 0.28 10.0 0.1 2.8 2 1 0 3 3 3 0 HAP1 N-terminal conserved region EMP24_GP25L PF01105.19 EFX04596.1 - 1.8e-45 154.9 1.3 2e-45 154.7 0.9 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_C36 PF05415.6 EFX04596.1 - 0.082 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase Fungal_trans_2 PF11951.3 EFX04598.1 - 0.00087 17.9 0.1 0.0012 17.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aldose_epim PF01263.15 EFX04599.1 - 8.4e-39 133.4 0.0 3.5e-37 128.1 0.0 2.0 1 1 0 1 1 1 1 Aldose 1-epimerase Ank_2 PF12796.2 EFX04600.1 - 7.4e-48 160.8 4.7 4.6e-09 36.5 0.0 8.4 2 2 6 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX04600.1 - 9.9e-38 127.8 17.8 3e-06 27.6 0.3 11.2 5 3 7 12 12 12 10 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX04600.1 - 8.4e-36 121.1 16.3 2.9e-06 27.3 0.0 10.4 7 4 3 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.25 EFX04600.1 - 6.5e-29 98.2 17.5 0.0007 19.2 0.0 14.6 16 0 0 16 16 16 6 Ankyrin repeat Ank_3 PF13606.1 EFX04600.1 - 1.1e-27 93.2 13.2 0.022 14.9 0.0 13.6 13 0 0 13 13 13 6 Ankyrin repeat DUF676 PF05057.9 EFX04600.1 - 1.6e-10 40.6 0.0 1.9e-07 30.6 0.0 2.3 2 0 0 2 2 2 2 Putative serine esterase (DUF676) PGAP1 PF07819.8 EFX04600.1 - 5.7e-09 35.8 0.0 0.0014 18.2 0.0 2.8 3 0 0 3 3 3 2 PGAP1-like protein Abhydrolase_6 PF12697.2 EFX04600.1 - 1.9e-06 27.9 0.0 0.035 13.9 0.0 3.1 2 0 0 2 2 2 2 Alpha/beta hydrolase family NACHT PF05729.7 EFX04600.1 - 2e-06 27.5 0.0 4.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EFX04600.1 - 2.2e-05 24.6 0.0 9.7e-05 22.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX04600.1 - 0.00022 21.2 0.2 0.001 19.0 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 EFX04600.1 - 0.0022 17.6 0.0 0.012 15.3 0.0 2.3 1 0 0 1 1 1 1 Part of AAA domain NB-ARC PF00931.17 EFX04600.1 - 0.0031 16.4 0.0 0.0065 15.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Arch_ATPase PF01637.13 EFX04600.1 - 0.0056 16.4 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA_33 PF13671.1 EFX04600.1 - 0.011 15.6 0.0 0.031 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFX04600.1 - 0.019 15.7 0.2 0.16 12.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.17 EFX04600.1 - 0.02 15.0 0.0 0.11 12.6 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA PF00004.24 EFX04600.1 - 0.021 15.0 0.0 0.056 13.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Abhydrolase_5 PF12695.2 EFX04600.1 - 0.023 14.4 0.0 2.4 7.9 0.0 3.3 3 0 0 3 3 3 0 Alpha/beta hydrolase family AAA_14 PF13173.1 EFX04600.1 - 0.024 14.5 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EFX04600.1 - 0.027 14.1 0.0 0.059 12.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Cutinase PF01083.17 EFX04600.1 - 0.19 11.4 0.0 7 6.3 0.0 2.3 2 0 0 2 2 2 0 Cutinase cobW PF02492.14 EFX04600.1 - 0.27 10.6 0.0 0.53 9.7 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.1 EFX04600.1 - 0.34 10.4 0.0 0.66 9.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Lectin_leg-like PF03388.8 EFX04601.1 - 4.4e-22 78.3 0.0 6.4e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Baculo_PEP_C PF04513.7 EFX04601.1 - 0.013 15.3 0.4 0.024 14.4 0.3 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG5 PF10392.4 EFX04601.1 - 0.026 14.4 0.6 0.048 13.6 0.4 1.4 1 0 0 1 1 1 0 Golgi transport complex subunit 5 IncA PF04156.9 EFX04601.1 - 0.026 14.1 0.8 0.041 13.4 0.6 1.3 1 0 0 1 1 1 0 IncA protein GCN5L1 PF06320.8 EFX04601.1 - 0.052 13.3 0.3 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) DUF4559 PF15112.1 EFX04601.1 - 0.082 12.0 1.2 0.12 11.5 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) LysM PF01476.15 EFX04602.1 - 3.1e-08 33.3 0.0 4.8e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 LysM domain Macoilin PF09726.4 EFX04602.1 - 2 6.6 7.3 3.6 5.7 5.1 1.4 1 0 0 1 1 1 0 Transmembrane protein Rad52_Rad22 PF04098.10 EFX04603.1 - 6.4e-61 204.6 0.0 9.2e-61 204.0 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein PAT1 PF09770.4 EFX04603.1 - 8 4.5 8.3 12 3.9 5.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Mito_carr PF00153.22 EFX04604.1 - 6.5e-54 179.6 3.5 2.1e-20 72.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SecE PF00584.15 EFX04604.1 - 0.12 11.9 0.1 0.33 10.5 0.0 1.7 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex IBR PF01485.16 EFX04605.1 - 4.8e-24 84.0 46.6 2.9e-12 46.2 5.2 4.5 3 1 1 4 4 4 3 IBR domain zf-C3HC4_2 PF13923.1 EFX04605.1 - 4.4e-06 26.6 7.5 4.4e-06 26.6 5.2 4.7 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX04605.1 - 2.9e-05 23.8 4.1 2.9e-05 23.8 2.9 3.6 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4 PF00097.20 EFX04605.1 - 0.00014 21.4 5.3 0.00014 21.4 3.6 4.5 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX04605.1 - 0.0052 16.4 7.5 0.0052 16.4 5.2 3.6 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EFX04605.1 - 0.019 14.8 0.6 0.019 14.8 0.4 4.5 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Pyr_redox_3 PF13738.1 EFX04606.1 - 6.7e-19 68.7 0.0 1.5e-18 67.6 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX04606.1 - 4.2e-09 36.3 0.0 3.2e-08 33.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.14 EFX04606.1 - 1.3e-06 26.9 0.0 4e-05 22.0 0.0 2.6 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFX04606.1 - 0.00026 20.0 0.0 0.12 11.2 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFX04606.1 - 0.0023 17.7 0.0 0.079 12.7 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFX04606.1 - 0.0071 16.2 0.0 0.046 13.5 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ribonuc_L-PSP PF01042.16 EFX04607.1 - 7.7e-22 77.3 0.0 9.1e-22 77.0 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP BID PF06393.6 EFX04607.1 - 0.042 13.1 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 BH3 interacting domain (BID) PEX11 PF05648.9 EFX04608.1 - 4e-60 202.8 0.2 4.5e-60 202.6 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) zf-C3HC4_3 PF13920.1 EFX04609.1 - 4e-08 32.7 12.4 6.7e-08 32.0 8.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FAM24 PF15193.1 EFX04609.1 - 0.026 14.7 3.7 0.047 13.8 2.6 1.5 1 0 0 1 1 1 0 FAM24 family Gly-zipper_OmpA PF13436.1 EFX04609.1 - 9.3 5.9 31.5 22 4.7 21.8 1.6 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Aldedh PF00171.17 EFX04610.1 - 5.8e-156 519.4 1.1 6.7e-156 519.2 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PBP1_TM PF14812.1 EFX04612.1 - 0.67 10.3 3.0 1.6 9.0 0.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WSC PF01822.14 EFX04613.1 - 1e-19 70.2 3.0 2.1e-19 69.2 2.1 1.5 1 0 0 1 1 1 1 WSC domain 2Fe-2S_thioredx PF01257.14 EFX04614.1 - 1.7e-58 196.3 0.1 2.2e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin HTH_30 PF13556.1 EFX04614.1 - 0.18 11.3 0.8 0.43 10.1 0.5 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Peptidase_M24 PF00557.19 EFX04615.1 - 8.8e-46 156.0 0.2 1.2e-45 155.6 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_S24 PF00717.18 EFX04616.1 - 1.4e-10 40.6 0.0 2e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like IF-2B PF01008.12 EFX04617.1 - 1.6e-33 115.8 0.0 2.5e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.17 EFX04617.1 - 0.034 13.7 0.3 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain OTU PF02338.14 EFX04618.1 - 5.3e-18 65.7 0.0 1.7e-17 64.1 0.0 1.9 1 1 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 EFX04618.1 - 0.0036 16.6 0.0 0.32 10.3 0.0 2.3 1 1 1 2 2 2 2 Peptidase C65 Otubain RXT2_N PF08595.6 EFX04618.1 - 0.76 9.5 4.6 20 4.9 1.6 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Syja_N PF02383.13 EFX04620.1 - 4.9e-85 285.0 0.0 8.6e-85 284.3 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Pro_CA PF00484.14 EFX04621.1 - 3.3e-25 88.8 0.2 5.9e-25 88.0 0.1 1.4 1 1 0 1 1 1 1 Carbonic anhydrase Tyrosinase PF00264.15 EFX04623.1 - 9e-24 84.8 0.1 9e-24 84.8 0.1 2.0 3 0 0 3 3 3 1 Common central domain of tyrosinase Ank_2 PF12796.2 EFX04623.1 - 1.3e-15 57.4 0.1 3.1e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX04623.1 - 1.1e-12 47.0 2.4 1.6e-06 27.6 0.3 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 EFX04623.1 - 9.7e-12 43.9 1.0 4.7e-05 23.2 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 EFX04623.1 - 6.1e-11 42.5 0.2 4e-06 27.1 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX04623.1 - 1.4e-10 41.0 0.4 0.00013 22.0 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) bZIP_1 PF00170.16 EFX04623.1 - 0.041 13.8 8.9 0.09 12.7 6.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor AAA PF00004.24 EFX04624.1 - 1.3e-15 57.7 0.0 2.5e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX04624.1 - 0.0053 16.9 0.0 2.2 8.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFX04624.1 - 0.0073 16.0 0.2 0.096 12.4 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 EFX04624.1 - 0.015 16.1 0.0 0.037 14.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 EFX04624.1 - 0.033 13.7 0.0 0.088 12.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EFX04624.1 - 0.045 13.1 0.1 0.38 10.1 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.9 EFX04624.1 - 0.069 12.8 0.0 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EFX04624.1 - 0.11 11.4 0.1 0.78 8.7 0.0 2.2 2 1 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus DUF3347 PF11827.3 EFX04624.1 - 0.13 12.2 0.1 0.13 12.2 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) CutC PF03932.9 EFX04625.1 - 7.5e-25 87.3 0.6 8e-24 84.0 0.4 2.4 1 1 0 1 1 1 1 CutC family PHD_2 PF13831.1 EFX04625.1 - 0.072 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 PHD-finger Sugar_tr PF00083.19 EFX04626.1 - 7e-83 278.6 25.2 8.5e-83 278.4 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04626.1 - 5.1e-25 87.9 32.5 2.1e-24 85.9 22.4 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.1 EFX04626.1 - 3.3 7.0 10.9 7.6 5.9 1.6 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) RNA_pol_Rpb2_6 PF00562.23 EFX04627.1 - 3.7e-125 417.6 0.1 8.7e-125 416.4 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EFX04627.1 - 1.1e-52 177.8 0.0 1.7e-52 177.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EFX04627.1 - 7.9e-48 162.3 0.0 1.6e-47 161.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 EFX04627.1 - 4.7e-30 103.6 0.0 1.4e-29 102.1 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.11 EFX04627.1 - 1.2e-22 79.3 0.1 2.8e-22 78.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 EFX04627.1 - 4.3e-22 77.8 1.0 9.9e-22 76.6 0.7 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.8 EFX04627.1 - 2.2e-20 72.2 0.1 5.5e-20 70.9 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 SBF2 PF12335.3 EFX04627.1 - 0.014 14.6 0.2 0.03 13.6 0.1 1.4 1 0 0 1 1 1 0 Myotubularin protein Pro_isomerase PF00160.16 EFX04628.1 - 2e-46 158.0 0.3 2.9e-46 157.5 0.2 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 EFX04628.1 - 1.8e-10 40.3 4.1 2.6e-05 23.7 0.2 2.3 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFX04628.1 - 7.6e-09 34.8 5.5 0.00012 21.6 0.6 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFX04628.1 - 1.5e-07 30.7 4.0 0.00028 20.3 0.3 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EFX04628.1 - 0.00084 19.2 1.9 0.77 9.7 0.4 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX04628.1 - 0.0032 18.0 9.2 0.33 11.6 3.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EFX04628.1 - 0.014 15.9 5.4 0.19 12.4 1.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFX04628.1 - 0.014 15.1 1.1 0.76 9.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX04628.1 - 0.024 15.0 1.6 1.6 9.3 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.1 EFX04628.1 - 0.03 14.1 1.7 0.17 11.7 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat FMN_dh PF01070.13 EFX04629.1 - 2.3e-117 391.8 0.4 3.1e-117 391.4 0.3 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EFX04629.1 - 1.3e-22 79.3 0.0 7.3e-22 76.9 0.0 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EFX04629.1 - 1.3e-07 30.8 0.0 2.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 EFX04629.1 - 0.0034 16.5 0.0 0.0057 15.8 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFX04629.1 - 0.011 14.6 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain BCDHK_Adom3 PF10436.4 EFX04630.1 - 2.4e-42 144.2 0.0 4e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EFX04630.1 - 6.4e-11 41.9 0.0 7.8e-10 38.4 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFX04630.1 - 0.0016 18.0 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EFX04630.1 - 0.0043 16.8 0.0 0.055 13.2 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain PALP PF00291.20 EFX04631.1 - 2e-62 211.1 3.7 4.4e-62 210.0 2.6 1.6 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme adh_short PF00106.20 EFX04631.1 - 5.9e-18 65.3 6.1 5.9e-18 65.3 4.2 3.4 3 0 0 3 3 3 2 short chain dehydrogenase KR PF08659.5 EFX04631.1 - 3e-05 23.7 18.2 8.2e-05 22.3 2.6 4.3 3 2 1 4 4 4 2 KR domain adh_short_C2 PF13561.1 EFX04631.1 - 0.011 15.5 0.1 0.91 9.2 0.0 3.0 3 0 0 3 3 3 0 Enoyl-(Acyl carrier protein) reductase Polyoma_coat2 PF00761.15 EFX04631.1 - 1.1 8.6 4.0 0.33 10.3 0.6 1.7 2 0 0 2 2 2 0 Polyomavirus coat protein Aldolase_II PF00596.16 EFX04632.1 - 2e-44 151.3 0.0 2.6e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain VHS PF00790.14 EFX04633.1 - 1.8e-34 118.4 0.1 3.6e-34 117.4 0.1 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.23 EFX04633.1 - 9.7e-17 60.1 0.0 1.9e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFX04633.1 - 1.5e-15 56.5 0.1 2.8e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFX04633.1 - 7.4e-15 54.1 0.0 1.4e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.15 EFX04633.1 - 0.0023 17.3 3.0 0.0077 15.7 2.1 1.9 1 0 0 1 1 1 1 Ubiquitin interaction motif zf-C2H2 PF00096.21 EFX04634.1 - 2.3e-06 27.5 3.2 0.011 15.9 0.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX04634.1 - 0.00018 21.6 1.9 0.039 14.3 0.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger Ribosomal_60s PF00428.14 EFX04634.1 - 0.0028 18.0 0.4 0.0028 18.0 0.3 3.2 2 1 0 2 2 2 1 60s Acidic ribosomal protein zf-C2H2_jaz PF12171.3 EFX04634.1 - 0.0082 16.2 1.8 2.3 8.4 0.1 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EFX04634.1 - 0.13 12.1 3.2 2.8 7.9 0.0 2.4 1 1 1 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 EFX04634.1 - 0.24 11.5 1.2 3.2 7.9 0.5 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Pkinase PF00069.20 EFX04635.1 - 1.7e-68 230.6 0.0 2.9e-68 229.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04635.1 - 1.2e-32 113.0 0.0 7.9e-29 100.5 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EFX04635.1 - 1.7e-05 23.9 0.1 0.024 13.6 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pox_ser-thr_kin PF05445.6 EFX04635.1 - 0.03 13.1 0.4 0.047 12.4 0.3 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MMtag PF10159.4 EFX04636.1 - 7.1e-29 99.6 3.1 7.1e-29 99.6 2.2 3.9 2 1 0 2 2 2 1 Kinase phosphorylation protein Amino_oxidase PF01593.19 EFX04637.1 - 3e-46 158.4 5.2 6.2e-43 147.5 3.6 2.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EFX04637.1 - 9.8e-15 54.3 0.2 2e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX04637.1 - 1.4e-07 30.8 2.7 2.4e-07 30.0 1.9 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX04637.1 - 1.5e-07 30.6 4.9 3.2e-07 29.5 3.4 1.7 1 1 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 EFX04637.1 - 1.2e-05 24.5 1.3 2e-05 23.8 0.9 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 EFX04637.1 - 1.3e-05 25.4 0.2 3.1e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX04637.1 - 1.5e-05 24.9 0.1 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX04637.1 - 2.3e-05 23.6 0.3 7.9e-05 21.8 0.3 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.1 EFX04637.1 - 2.4e-05 24.5 1.3 7.6e-05 22.8 0.9 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX04637.1 - 3.2e-05 22.5 0.3 5.4e-05 21.8 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.17 EFX04637.1 - 0.00012 21.0 0.2 0.00019 20.4 0.2 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A K_oxygenase PF13434.1 EFX04637.1 - 0.00014 20.9 0.0 0.0025 16.7 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.2 EFX04637.1 - 0.00018 20.7 3.7 0.0002 20.5 1.8 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.16 EFX04637.1 - 0.0055 16.2 0.2 0.011 15.3 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 EFX04637.1 - 0.0079 15.1 0.2 0.012 14.5 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein 3HCDH_N PF02737.13 EFX04637.1 - 0.021 14.4 0.1 0.044 13.4 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 EFX04637.1 - 0.062 12.6 0.1 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain DUF4611 PF15387.1 EFX04637.1 - 0.62 10.2 4.5 0.42 10.7 1.6 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4611) NAD_binding_9 PF13454.1 EFX04637.1 - 2.4 7.9 5.2 10 5.8 0.1 2.8 2 1 1 3 3 3 0 FAD-NAD(P)-binding SRP19 PF01922.12 EFX04638.1 - 2.7e-27 95.1 0.0 4.5e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 SRP19 protein DUF2360 PF10152.4 EFX04638.1 - 0.32 11.2 3.3 0.29 11.4 0.4 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF1180 PF06679.7 EFX04638.1 - 2.3 8.0 5.3 0.58 10.0 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Nucleoporin_FG PF13634.1 EFX04639.1 - 2.5e-10 40.5 67.7 7.9e-08 32.5 16.4 4.2 3 1 1 4 4 4 2 Nucleoporin FG repeat region SEA PF01390.15 EFX04642.1 - 0.084 12.5 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 SEA domain MFS_1 PF07690.11 EFX04643.1 - 1.4e-35 122.7 32.8 1.8e-35 122.3 22.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily zf-C2H2 PF00096.21 EFX04645.1 - 2.3e-05 24.4 17.7 0.0023 18.1 2.4 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX04645.1 - 3.6e-05 23.7 18.5 0.0013 18.9 2.8 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger DIM1 PF02966.11 EFX04646.1 - 1.1e-65 219.1 0.2 1.2e-65 218.9 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.1 EFX04646.1 - 0.0032 17.5 0.2 0.0056 16.7 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like MaoC_dehydratas PF01575.14 EFX04647.1 - 1.3e-21 76.2 0.0 2.3e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 EFX04647.1 - 3.5e-08 33.3 0.0 3.6e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Aconitase PF00330.15 EFX04648.1 - 1.9e-147 491.5 0.0 5.2e-147 490.0 0.0 1.6 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFX04648.1 - 1.4e-37 128.6 0.0 2.4e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain KH_1 PF00013.24 EFX04649.1 - 0.0084 15.7 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EFX04649.1 - 0.02 14.5 0.0 0.05 13.2 0.0 1.7 1 0 0 1 1 1 0 KH domain CTNNBL PF08216.6 EFX04650.1 - 1.2e-30 105.2 0.0 1e-29 102.2 0.0 2.4 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear HEAT_2 PF13646.1 EFX04650.1 - 0.02 15.1 0.2 0.02 15.1 0.1 4.7 5 1 0 5 5 5 0 HEAT repeats MFS_1 PF07690.11 EFX04651.1 - 3.5e-21 75.2 15.2 3.5e-21 75.2 10.5 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily RF-1 PF00472.15 EFX04653.1 - 1.4e-34 118.3 3.3 1.4e-34 118.3 2.3 1.8 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.13 EFX04653.1 - 2.9e-26 91.4 0.0 8.7e-26 89.9 0.0 1.9 1 0 0 1 1 1 1 PCRF domain DUF1912 PF08930.5 EFX04653.1 - 0.015 15.3 0.9 0.76 9.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) Stn1 PF10451.4 EFX04654.1 - 0.88 8.3 0.1 1.4 7.6 0.1 1.3 1 0 0 1 1 1 0 Telomere regulation protein Stn1 Acetyltransf_7 PF13508.1 EFX04656.1 - 1.1e-06 28.7 0.0 1.3e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX04656.1 - 1.8e-06 27.9 0.0 2.2e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EFX04656.1 - 0.00015 21.4 0.0 0.00018 21.1 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EFX04656.1 - 0.00022 21.3 0.0 0.00029 20.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX04656.1 - 0.038 13.8 0.0 0.043 13.6 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Exo_endo_phos PF03372.18 EFX04657.1 - 9.4e-13 48.6 0.3 2.4e-12 47.3 0.1 1.8 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family HMG_box PF00505.14 EFX04658.1 - 1.2e-21 76.7 0.5 2.1e-21 75.9 0.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFX04658.1 - 0.003 17.8 0.1 0.0066 16.7 0.1 1.6 1 0 0 1 1 1 1 HMG-box domain FYVE PF01363.16 EFX04659.1 - 3.3e-15 55.7 5.6 5.7e-15 54.9 3.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger LBR_tudor PF09465.5 EFX04660.1 - 0.01 15.4 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF1325 PF07039.6 EFX04660.1 - 0.011 15.3 0.1 0.022 14.3 0.1 1.5 1 0 0 1 1 1 0 SGF29 tudor-like domain DUF4537 PF15057.1 EFX04660.1 - 0.031 14.0 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) TauD PF02668.11 EFX04661.1 - 3.3e-34 118.7 0.1 4.9e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ribosomal_L4 PF00573.17 EFX04662.1 - 4.6e-43 146.8 0.0 6.3e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Methyltransf_26 PF13659.1 EFX04663.1 - 2.7e-16 59.6 0.3 7.8e-16 58.1 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04663.1 - 4e-12 45.9 0.0 7e-12 45.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04663.1 - 1e-10 42.1 0.0 2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04663.1 - 1.2e-08 35.2 0.0 2.9e-08 33.9 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 EFX04663.1 - 1.7e-07 30.7 0.0 1.9e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 EFX04663.1 - 0.00018 21.1 0.0 0.0003 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 EFX04663.1 - 0.00036 19.7 0.0 0.00051 19.2 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_23 PF13489.1 EFX04663.1 - 0.00062 19.5 0.0 0.0014 18.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 EFX04663.1 - 0.00084 18.9 0.0 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.7 EFX04663.1 - 0.0018 18.7 0.0 0.0034 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 EFX04663.1 - 0.0068 15.9 0.0 0.04 13.4 0.0 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.13 EFX04663.1 - 0.0098 15.0 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFX04663.1 - 0.018 15.4 0.0 0.032 14.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EFX04663.1 - 0.026 13.6 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) COMPASS-Shg1 PF05205.7 EFX04664.1 - 3.5e-26 91.5 0.2 8.6e-26 90.2 0.1 1.7 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 Pribosyltran_N PF13793.1 EFX04665.1 - 6.4e-39 132.2 0.6 5.7e-37 125.9 0.0 2.6 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EFX04665.1 - 9e-37 126.5 1.1 1.5e-30 106.3 0.2 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EFX04665.1 - 8.8e-11 41.6 1.3 8.8e-11 41.6 0.9 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EFX04665.1 - 0.0062 15.7 0.5 0.01 15.0 0.3 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF218 PF02698.12 EFX04665.1 - 0.045 13.2 0.0 0.081 12.4 0.0 1.5 1 0 0 1 1 1 0 DUF218 domain PCMT PF01135.14 EFX04666.1 - 2.7e-47 161.0 0.0 5.7e-47 159.9 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 EFX04666.1 - 1.1e-08 35.1 0.6 1.1e-08 35.1 0.4 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04666.1 - 7.3e-07 29.7 0.2 1.4e-06 28.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04666.1 - 6.5e-06 25.8 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EFX04666.1 - 0.0022 17.6 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04666.1 - 0.044 14.2 0.0 0.11 13.0 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 EFX04666.1 - 0.044 12.8 0.0 0.078 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_23 PF13489.1 EFX04666.1 - 0.16 11.7 0.0 0.24 11.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain tRNA-synt_1g PF09334.6 EFX04667.1 - 6.7e-110 367.4 0.0 1e-108 363.5 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EFX04667.1 - 2.4e-25 88.5 0.4 5.2e-12 44.5 0.0 3.7 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 EFX04667.1 - 7.7e-07 28.5 0.0 0.0047 16.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Peptidase_C28 PF05408.6 EFX04667.1 - 0.093 12.1 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Foot-and-mouth virus L-proteinase SHS2_Rpb7-N PF03876.12 EFX04668.1 - 1.3e-14 54.0 0.0 1.9e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF2420 PF10336.4 EFX04669.1 - 9e-06 25.2 0.0 1.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Glyco_hydro_76 PF03663.9 EFX04670.1 - 5.4e-147 490.0 6.3 7e-147 489.6 4.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 EFX04670.1 - 0.05 12.6 4.1 2.8 6.9 0.0 3.0 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Aminotran_3 PF00202.16 EFX04672.1 - 4.8e-82 275.5 0.0 7.5e-82 274.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III Exo70 PF03081.10 EFX04672.1 - 8e-72 242.0 0.0 1.3e-71 241.3 0.0 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit TPR_14 PF13428.1 EFX04673.1 - 5.8e-22 76.1 21.8 0.0012 19.3 0.1 11.5 9 2 4 13 13 13 5 Tetratricopeptide repeat TPR_19 PF14559.1 EFX04673.1 - 5.6e-18 65.0 1.7 4.1e-05 23.8 0.0 7.3 7 2 0 7 7 6 2 Tetratricopeptide repeat HAT PF02184.11 EFX04673.1 - 1e-17 63.5 61.4 2.2e-08 33.6 1.9 13.3 14 0 0 14 14 14 5 HAT (Half-A-TPR) repeat TPR_16 PF13432.1 EFX04673.1 - 4e-15 56.0 20.2 2e-05 25.1 0.1 8.2 8 1 1 9 9 9 4 Tetratricopeptide repeat Suf PF05843.9 EFX04673.1 - 6.4e-15 55.6 11.8 0.00048 19.9 0.2 6.6 5 2 1 6 6 6 4 Suppressor of forked protein (Suf) TPR_12 PF13424.1 EFX04673.1 - 5.4e-08 32.6 10.3 0.95 9.4 0.0 7.8 8 2 1 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX04673.1 - 2.2e-06 27.4 4.9 0.68 10.2 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.1 EFX04673.1 - 1e-05 25.0 1.7 0.98 9.1 0.0 5.5 5 1 1 6 6 6 1 TPR repeat U3_assoc_6 PF08640.6 EFX04673.1 - 0.0016 18.1 18.0 0.099 12.4 1.3 6.4 5 2 2 7 7 7 1 U3 small nucleolar RNA-associated protein 6 TPR_8 PF13181.1 EFX04673.1 - 0.0026 17.4 0.0 68 3.5 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX04673.1 - 0.076 13.5 17.5 36 5.0 0.0 8.8 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFX04673.1 - 0.14 12.1 17.7 0.74 9.8 0.0 7.9 10 0 0 10 10 10 0 Tetratricopeptide repeat MFS_1 PF07690.11 EFX04675.1 - 7.2e-17 61.1 39.8 3e-15 55.7 10.7 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 EFX04675.1 - 2.7e-11 43.2 6.2 2.7e-11 43.2 4.3 2.1 2 0 0 2 2 2 1 Nodulin-like Mpv17_PMP22 PF04117.7 EFX04675.1 - 0.095 12.3 0.1 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Mpv17 / PMP22 family NPP1 PF05630.6 EFX04676.1 - 5.7e-58 196.0 0.1 6.6e-58 195.8 0.1 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) GspL_C PF12693.2 EFX04677.1 - 0.077 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 GspL periplasmic domain DUF2681 PF10883.3 EFX04677.1 - 0.095 12.9 0.2 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF1049 PF06305.6 EFX04677.1 - 0.12 11.9 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) UPF0104 PF03706.8 EFX04677.1 - 0.15 11.2 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) DUF4611 PF15387.1 EFX04678.1 - 0.0048 17.0 1.8 0.045 13.9 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4611) Claudin_2 PF13903.1 EFX04680.1 - 0.065 12.9 0.1 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4418 PF14387.1 EFX04680.1 - 0.072 12.8 1.8 0.094 12.4 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) DUF3146 PF11344.3 EFX04680.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) AMMECR1 PF01871.12 EFX04682.1 - 1.4e-41 141.5 0.0 1.8e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 Isochorismatase PF00857.15 EFX04683.1 - 5.5e-17 62.2 0.0 1e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family SPC25 PF06703.6 EFX04683.1 - 0.033 13.7 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) V-ATPase_H_N PF03224.9 EFX04684.1 - 7.5e-62 209.2 0.0 9.1e-62 208.9 0.0 1.1 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 EFX04684.1 - 7.8e-38 129.0 0.0 2.7e-37 127.2 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H TFCD_C PF12612.3 EFX04684.1 - 0.036 13.4 1.7 0.048 13.0 0.3 1.8 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal Kelch_5 PF13854.1 EFX04685.1 - 3.3e-11 42.8 0.9 3.3e-11 42.8 0.6 6.0 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.1 EFX04685.1 - 3.9e-05 23.6 18.9 0.095 12.9 0.3 6.0 5 1 1 6 6 6 3 Kelch motif VSP PF03302.8 EFX04685.1 - 0.00046 18.9 1.9 0.00071 18.3 1.3 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Kelch_2 PF07646.10 EFX04685.1 - 0.00046 19.8 11.4 4.7 7.1 0.0 6.7 7 0 0 7 7 7 2 Kelch motif Kelch_1 PF01344.20 EFX04685.1 - 0.0054 16.2 8.4 0.062 12.8 0.1 5.1 6 0 0 6 6 6 1 Kelch motif DUF1183 PF06682.7 EFX04685.1 - 0.059 12.9 5.6 0.097 12.2 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Herpes_gE PF02480.11 EFX04685.1 - 0.22 9.7 0.2 0.33 9.1 0.2 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E E1-E2_ATPase PF00122.15 EFX04686.1 - 1.3e-20 73.3 0.0 2.8e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 EFX04686.1 - 1e-19 71.4 0.1 3.2e-18 66.5 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EFX04686.1 - 6e-17 62.7 0.6 9.6e-16 58.8 0.4 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX04686.1 - 1.2e-12 47.5 0.0 3.5e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFX04686.1 - 0.00077 19.1 0.6 0.0068 16.0 0.4 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX04686.1 - 0.064 13.4 0.3 0.18 12.0 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase AA_permease_2 PF13520.1 EFX04687.1 - 7e-60 202.7 52.7 8.8e-60 202.4 36.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX04687.1 - 8.9e-13 47.3 43.7 1.3e-12 46.8 30.3 1.1 1 0 0 1 1 1 1 Amino acid permease Acetyltransf_7 PF13508.1 EFX04688.1 - 5.4e-08 32.8 0.0 1.5e-07 31.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX04688.1 - 1e-06 28.6 0.0 2e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EFX04688.1 - 1.2e-05 25.3 0.0 3.4e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX04688.1 - 0.00015 21.6 0.0 0.061 13.1 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX04688.1 - 0.00055 19.6 0.0 0.00086 19.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 EFX04688.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase LRR_6 PF13516.1 EFX04689.1 - 6.3e-06 25.7 4.6 2.7 8.3 0.0 6.8 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.2 EFX04689.1 - 0.0025 17.3 4.4 0.17 11.5 0.7 4.8 7 0 0 7 7 7 1 Leucine Rich repeats (2 copies) Cnd1_N PF12922.2 EFX04690.1 - 7.8e-60 201.3 2.2 5.6e-59 198.6 0.0 2.8 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.2 EFX04690.1 - 5.5e-52 176.2 0.4 1e-49 168.7 0.0 2.9 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EFX04690.1 - 4.4e-10 39.6 3.2 0.00037 20.7 0.0 5.4 4 2 1 5 5 5 2 HEAT repeats HEAT PF02985.17 EFX04690.1 - 4.8e-06 26.1 5.7 0.23 11.6 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 EFX04690.1 - 0.00013 22.2 4.2 0.22 12.0 0.1 5.4 5 0 0 5 5 5 1 HEAT-like repeat Cnd3 PF12719.2 EFX04690.1 - 0.013 14.5 1.1 0.043 12.8 0.2 2.4 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain G_glu_transpept PF01019.16 EFX04691.1 - 1e-143 479.5 0.0 1.2e-143 479.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Hydrolase PF00702.21 EFX04692.1 - 4.5e-18 66.4 0.0 1.2e-17 65.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EFX04692.1 - 1.3e-14 53.8 0.0 4e-14 52.2 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 EFX04692.1 - 4.1e-10 40.1 0.0 1.1e-09 38.8 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EFX04692.1 - 3e-06 27.1 0.0 8.8e-06 25.5 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EFX04692.1 - 0.0036 16.9 0.0 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX04692.1 - 0.091 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase GP40 PF11025.3 EFX04692.1 - 0.12 11.9 0.0 0.33 10.4 0.0 1.7 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium AA_permease_C PF13906.1 EFX04692.1 - 5.2 7.0 9.9 0.64 9.9 3.1 2.3 2 0 0 2 2 2 0 C-terminus of AA_permease Oxidored_FMN PF00724.15 EFX04693.1 - 3.2e-92 309.1 0.0 3.6e-92 308.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family LSM PF01423.17 EFX04694.1 - 0.01 15.3 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 0 LSM domain AAA_16 PF13191.1 EFX04695.1 - 5.2e-06 26.5 0.0 1.3e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF676 PF05057.9 EFX04695.1 - 0.00031 20.0 0.0 0.00062 19.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EFX04695.1 - 0.0027 17.3 0.0 0.0049 16.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein AAA_22 PF13401.1 EFX04695.1 - 0.032 14.3 0.0 0.098 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 EFX04695.1 - 0.089 11.8 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus NACHT PF05729.7 EFX04695.1 - 0.096 12.3 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF2975 PF11188.3 EFX04696.1 - 0.0055 16.4 3.6 0.17 11.5 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2975) DUF2244 PF10003.4 EFX04696.1 - 0.79 9.0 7.4 0.064 12.6 1.1 2.1 2 1 0 2 2 2 0 Integral membrane protein (DUF2244) Ndc1_Nup PF09531.5 EFX04696.1 - 1.8 6.8 8.6 2.4 6.4 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Methyltransf_23 PF13489.1 EFX04697.1 - 5.2e-22 78.2 0.0 7.1e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04697.1 - 7.3e-11 42.4 0.0 1.3e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04697.1 - 8.1e-10 38.4 0.0 9.1e-09 35.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04697.1 - 1.9e-09 37.9 0.0 9.9e-09 35.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04697.1 - 3.8e-09 37.1 0.0 4.9e-08 33.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX04697.1 - 7.7e-07 28.4 0.0 1.8e-05 23.9 0.0 2.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX04697.1 - 8.8e-06 26.0 0.0 2.4e-05 24.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX04697.1 - 0.00038 19.5 0.0 0.00085 18.4 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX04697.1 - 0.0013 18.7 0.0 0.0043 17.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.7 EFX04697.1 - 0.0066 16.0 0.0 0.009 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PrmA PF06325.8 EFX04697.1 - 0.012 14.6 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EFX04697.1 - 0.015 14.6 0.0 0.04 13.2 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain CMAS PF02353.15 EFX04697.1 - 0.055 12.5 0.0 0.11 11.5 0.0 1.6 2 1 0 2 2 2 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 EFX04697.1 - 0.066 13.1 0.4 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.4 EFX04697.1 - 0.098 12.1 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Ribophorin_I PF04597.9 EFX04698.1 - 2.3e-151 504.2 0.0 2.6e-151 504.0 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Sugar_tr PF00083.19 EFX04699.1 - 5.7e-30 104.2 35.1 1.3e-19 70.1 10.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFX04699.1 - 1.2e-19 70.3 45.3 4.5e-11 42.0 19.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 EFX04699.1 - 1.6 8.7 8.5 1 9.4 0.7 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1228) Methyltransf_23 PF13489.1 EFX04700.1 - 3.6e-13 49.5 0.0 2e-12 47.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04700.1 - 8e-12 45.4 0.0 1.2e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04700.1 - 2.3e-11 44.0 0.0 3.3e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04700.1 - 3.7e-11 43.3 0.0 6e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04700.1 - 3.8e-11 43.5 0.0 6e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX04700.1 - 4.2e-09 36.4 0.3 9.1e-09 35.3 0.2 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX04700.1 - 2e-07 30.4 0.0 2.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFX04700.1 - 2.4e-07 30.4 0.0 6.3e-07 29.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFX04700.1 - 7.1e-05 22.0 0.0 8.2e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 EFX04700.1 - 0.00011 21.5 0.0 0.00021 20.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.6 EFX04700.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_20 PF12147.3 EFX04700.1 - 0.0016 17.3 0.0 0.0023 16.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 EFX04700.1 - 0.0034 16.5 0.0 0.004 16.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0146 PF03686.8 EFX04700.1 - 0.006 16.4 0.0 0.0097 15.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0146) PCMT PF01135.14 EFX04700.1 - 0.0061 16.1 0.0 0.0075 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 EFX04700.1 - 0.011 14.8 0.0 0.051 12.6 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase 3HCDH_N PF02737.13 EFX04700.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NodS PF05401.6 EFX04700.1 - 0.025 13.9 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.1 EFX04700.1 - 0.044 13.4 0.0 0.06 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.9 EFX04700.1 - 0.065 12.3 0.0 0.091 11.9 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 EFX04700.1 - 0.069 11.8 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) TrkA_N PF02254.13 EFX04700.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 2 0 0 2 2 2 0 TrkA-N domain URO-D PF01208.12 EFX04700.1 - 0.14 11.0 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) Terpene_synth_C PF03936.11 EFX04702.1 - 9.9e-15 54.4 0.2 1.4e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain Enoyl_reductase PF12241.3 EFX04704.1 - 0.0025 16.8 0.1 0.0044 16.0 0.0 1.4 1 1 0 1 1 1 1 Trans-2-enoyl-CoA reductase catalytic region VHL PF01847.11 EFX04704.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 von Hippel-Lindau disease tumour suppressor protein DAGAT PF03982.8 EFX04705.1 - 7.8e-86 287.4 0.0 1e-85 287.0 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DNA_mis_repair PF01119.14 EFX04708.1 - 1.9e-19 69.2 0.0 3.9e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.6 EFX04708.1 - 3.3e-18 65.6 0.0 1.4e-17 63.6 0.0 2.1 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.1 EFX04708.1 - 9.4e-12 44.7 0.0 2.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EFX04708.1 - 2.4e-10 40.1 0.0 8.5e-10 38.3 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1828 PF08861.5 EFX04708.1 - 0.014 15.0 0.1 5.5 6.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF1828 DnaJ PF00226.26 EFX04710.1 - 3.4e-13 49.1 3.2 7.3e-13 48.0 0.9 2.0 2 0 0 2 2 2 1 DnaJ domain NicO PF03824.11 EFX04710.1 - 1 8.6 5.1 0.84 8.8 0.0 2.1 2 0 0 2 2 2 0 High-affinity nickel-transport protein Vpu PF00558.14 EFX04710.1 - 1.9 8.0 4.1 1.4 8.5 0.1 2.1 1 1 1 2 2 2 0 Vpu protein zf-C2H2_4 PF13894.1 EFX04712.1 - 0.099 13.0 1.1 0.36 11.2 0.8 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger Cupin_8 PF13621.1 EFX04713.1 - 1.8e-23 83.3 0.0 2.5e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 EFX04713.1 - 0.0001 21.6 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.17 EFX04713.1 - 0.002 18.3 0.0 0.039 14.2 0.0 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.6 EFX04713.1 - 0.025 14.0 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Pyr_redox_3 PF13738.1 EFX04714.1 - 6.3e-25 88.4 0.2 4.4e-24 85.6 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX04714.1 - 7.1e-11 41.0 0.0 8.3e-10 37.4 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX04714.1 - 8.7e-10 38.4 0.1 6.7e-09 35.6 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX04714.1 - 7.5e-08 31.6 0.6 0.00037 19.5 0.3 3.3 2 2 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.12 EFX04714.1 - 1.1e-05 24.6 2.8 6.4e-05 22.1 0.0 2.6 3 0 0 3 3 3 1 Thi4 family K_oxygenase PF13434.1 EFX04714.1 - 2.8e-05 23.2 0.1 0.0052 15.7 0.0 3.1 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.7 EFX04714.1 - 4.2e-05 22.6 0.3 0.00011 21.2 0.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 EFX04714.1 - 0.00049 20.0 0.1 1.4 8.7 0.2 3.0 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX04714.1 - 0.00059 20.1 0.0 1.7 9.1 0.0 2.7 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 EFX04714.1 - 0.00065 19.8 0.2 0.1 12.7 0.0 3.0 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.19 EFX04714.1 - 0.0038 16.1 0.0 0.0053 15.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 EFX04714.1 - 0.0043 16.1 0.1 0.0095 15.0 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.19 EFX04714.1 - 0.0083 15.2 0.0 0.07 12.1 0.0 2.1 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase GIDA PF01134.17 EFX04714.1 - 0.02 13.7 0.1 0.51 9.1 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.1 EFX04714.1 - 0.05 13.3 0.5 18 5.0 0.0 3.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_oxidored PF12831.2 EFX04714.1 - 0.12 11.4 0.1 0.12 11.4 0.1 2.0 3 0 0 3 3 3 0 FAD dependent oxidoreductase LSM PF01423.17 EFX04715.1 - 3.9e-20 71.1 0.1 4.3e-20 71.0 0.1 1.0 1 0 0 1 1 1 1 LSM domain AMP-binding PF00501.23 EFX04716.1 - 1e-75 254.7 0.0 1.3e-75 254.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EFX04716.1 - 2.4e-08 34.8 0.1 1.1e-07 32.6 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Pilin_PilX PF11530.3 EFX04716.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Minor type IV pilin, PilX MFS_1 PF07690.11 EFX04717.1 - 1.9e-17 63.0 39.6 6.9e-17 61.1 24.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2208 PF09973.4 EFX04717.1 - 0.21 10.8 2.9 0.21 10.7 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) CRT10 PF08728.5 EFX04718.1 - 8.3e-09 34.0 0.4 3.7e-06 25.2 0.0 3.1 3 0 0 3 3 3 2 CRT10 RgpF PF05045.7 EFX04719.1 - 0.12 10.8 0.1 0.33 9.4 0.0 1.7 2 0 0 2 2 2 0 Rhamnan synthesis protein F G-alpha PF00503.15 EFX04721.1 - 3.5e-125 417.7 1.0 4.1e-125 417.4 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EFX04721.1 - 6.1e-15 54.8 1.3 3.3e-10 39.4 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 EFX04721.1 - 0.00098 19.6 0.0 0.85 10.1 0.0 2.8 3 0 0 3 3 3 2 Miro-like protein Gtr1_RagA PF04670.7 EFX04721.1 - 0.0027 16.9 4.4 0.65 9.0 3.0 2.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 EFX04721.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RibD_C PF01872.12 EFX04722.1 - 0.056 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 RibD C-terminal domain Ank_2 PF12796.2 EFX04723.1 - 7.1e-48 160.8 0.0 1.9e-12 47.3 0.0 4.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX04723.1 - 8.8e-43 143.9 8.4 5.2e-10 39.5 0.0 6.5 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.25 EFX04723.1 - 1.7e-38 128.5 0.2 0.00048 19.7 0.0 8.0 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.1 EFX04723.1 - 5.7e-38 128.0 5.3 6e-09 35.8 0.0 6.6 3 1 4 7 7 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX04723.1 - 2.2e-28 95.4 0.1 0.045 14.0 0.0 8.5 8 0 0 8 8 7 7 Ankyrin repeat NACHT PF05729.7 EFX04723.1 - 3.2e-10 39.8 0.1 7.1e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 NACHT domain DUF676 PF05057.9 EFX04723.1 - 1.2e-05 24.6 0.0 3.5e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 EFX04723.1 - 0.00026 20.9 0.1 0.00064 19.6 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family AAA_16 PF13191.1 EFX04723.1 - 0.0004 20.4 0.5 0.0018 18.2 0.3 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX04723.1 - 0.00047 20.3 0.0 0.0017 18.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain Abhydrolase_5 PF12695.2 EFX04723.1 - 0.0012 18.6 0.1 0.0031 17.2 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EFX04723.1 - 0.0016 18.0 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein AAA_19 PF13245.1 EFX04723.1 - 0.024 14.3 0.1 0.65 9.7 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain AAA_29 PF13555.1 EFX04723.1 - 0.045 13.2 0.0 0.28 10.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX04723.1 - 0.061 13.6 0.0 0.18 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFX04723.1 - 0.066 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Viral_helicase1 PF01443.13 EFX04723.1 - 0.089 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.1 EFX04723.1 - 0.1 12.1 0.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain Rpr2 PF04032.11 EFX04723.1 - 0.11 12.4 0.2 0.29 11.0 0.1 1.7 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain cobW PF02492.14 EFX04723.1 - 0.14 11.6 0.1 0.27 10.6 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Cutinase PF01083.17 EFX04723.1 - 0.19 11.4 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Cutinase RNA_pol_Rpb1_5 PF04998.12 EFX04724.1 - 6.9e-86 287.9 0.1 1.1e-85 287.2 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EFX04724.1 - 9.8e-67 224.0 0.0 2.5e-66 222.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.7 EFX04724.1 - 1.1e-57 195.7 0.0 1.7e-52 178.7 0.0 2.3 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.13 EFX04724.1 - 9.8e-35 119.6 0.0 2.2e-34 118.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EFX04724.1 - 4.6e-27 93.8 0.0 1.5e-26 92.2 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Glutaredoxin2_C PF04399.8 EFX04724.1 - 0.16 11.5 0.2 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Peptidase_S8 PF00082.17 EFX04725.1 - 3e-42 144.7 4.1 6.6e-42 143.5 2.8 1.6 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 EFX04725.1 - 2.1e-09 37.7 0.1 1.3e-08 35.2 0.0 2.3 2 0 0 2 2 2 1 Fn3-like domain (DUF1034) PA PF02225.17 EFX04725.1 - 9.7e-05 22.0 0.0 0.00027 20.5 0.0 1.8 1 0 0 1 1 1 1 PA domain Fungal_trans PF04082.13 EFX04726.1 - 7.7e-62 208.5 0.1 1.1e-61 207.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFX04726.1 - 0.00058 20.0 4.1 0.00058 20.0 2.8 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX04726.1 - 0.0006 19.9 3.6 0.0006 19.9 2.5 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EFX04726.1 - 9.7 6.6 16.4 2.8 8.3 2.7 2.9 3 0 0 3 3 3 0 Zinc-finger double domain TauD PF02668.11 EFX04728.1 - 6.5e-12 45.6 0.1 7.2e-08 32.4 0.0 2.1 1 1 1 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 EFX04728.1 - 0.033 13.0 0.0 0.053 12.4 0.0 1.3 1 0 0 1 1 1 0 CsiD adh_short_C2 PF13561.1 EFX04729.1 - 1.1e-24 87.5 0.1 1.3e-24 87.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX04729.1 - 5.8e-24 84.8 1.8 9.1e-24 84.2 1.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX04729.1 - 1.9e-11 43.9 0.7 3e-11 43.3 0.5 1.3 1 0 0 1 1 1 1 KR domain ThiF PF00899.16 EFX04729.1 - 0.052 13.3 1.1 0.19 11.5 0.4 2.1 2 1 1 3 3 3 0 ThiF family Nbl1_Borealin_N PF10444.4 EFX04731.1 - 6.8e-23 79.8 2.4 1.1e-22 79.1 1.7 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal Aldedh PF00171.17 EFX04732.1 - 3.6e-07 28.8 0.0 0.0028 16.0 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Cna_B PF05738.8 EFX04732.1 - 0.036 13.8 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 Cna protein B-type domain Glyco_hydro_92 PF07971.7 EFX04733.1 - 4.6e-161 536.8 0.0 6.6e-161 536.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 HECT PF00632.20 EFX04733.1 - 1.3e-73 247.9 0.0 2.2e-73 247.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Tim17 PF02466.14 EFX04734.1 - 7.2e-26 90.7 4.1 9.8e-26 90.2 2.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF202 PF02656.10 EFX04735.1 - 1e-13 51.3 3.7 1e-13 51.3 2.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Bax1-I PF01027.15 EFX04735.1 - 0.014 15.0 4.7 0.018 14.6 3.3 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF983 PF06170.7 EFX04735.1 - 0.038 14.0 1.3 5.8 7.1 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF983) 7tm_6 PF02949.15 EFX04735.1 - 0.064 12.1 0.1 0.11 11.3 0.1 1.3 1 0 0 1 1 1 0 7tm Odorant receptor DUF2189 PF09955.4 EFX04735.1 - 0.47 10.3 7.0 0.096 12.6 1.1 1.9 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) 7TMR-DISM_7TM PF07695.6 EFX04735.1 - 1.2 8.7 9.3 3.6 7.2 6.4 1.7 1 1 0 1 1 1 0 7TM diverse intracellular signalling DUF2207 PF09972.4 EFX04735.1 - 7.2 5.0 6.5 11 4.4 4.5 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) ASXH PF13919.1 EFX04736.1 - 8e-22 77.5 0.2 1.3e-21 76.8 0.1 1.3 1 0 0 1 1 1 1 Asx homology domain PI-PLC-X PF00388.14 EFX04737.1 - 1.3e-08 34.4 0.0 1.9e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain adh_short_C2 PF13561.1 EFX04738.1 - 8.3e-27 94.5 0.0 1.1e-26 94.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX04738.1 - 1.5e-20 73.8 0.3 2.9e-20 72.8 0.2 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX04738.1 - 1.2e-07 31.5 0.3 2e-06 27.5 0.2 2.1 1 1 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.14 EFX04738.1 - 0.0014 17.8 0.1 0.0036 16.4 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.16 EFX04738.1 - 0.0014 18.2 0.1 0.0084 15.7 0.0 1.9 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PALP PF00291.20 EFX04738.1 - 0.061 12.5 0.0 0.091 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme DFP PF04127.10 EFX04738.1 - 0.083 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Herpes_gE PF02480.11 EFX04739.1 - 0.019 13.2 0.0 0.027 12.7 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Telomere_Sde2 PF13019.1 EFX04739.1 - 0.091 12.4 1.1 0.18 11.4 0.8 1.5 1 0 0 1 1 1 0 Telomere stability and silencing Metal_resist PF13801.1 EFX04739.1 - 0.43 10.5 1.8 2.5 8.0 0.1 2.3 2 0 0 2 2 2 0 Heavy-metal resistance HAUS2 PF15003.1 EFX04740.1 - 0.00045 19.3 0.0 0.00072 18.7 0.0 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 PLA2_B PF01735.13 EFX04741.1 - 2.8e-181 602.9 12.2 1.1e-152 508.6 0.7 2.1 1 1 1 2 2 2 2 Lysophospholipase catalytic domain La PF05383.12 EFX04742.1 - 2.8e-17 62.2 0.0 4.8e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 La domain NUDIX PF00293.23 EFX04743.1 - 2.1e-16 59.8 0.7 2.5e-16 59.5 0.5 1.1 1 0 0 1 1 1 1 NUDIX domain DUF4563 PF15124.1 EFX04743.1 - 0.026 14.0 0.0 0.034 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4563) Methyltransf_23 PF13489.1 EFX04744.1 - 0.0011 18.7 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04744.1 - 0.007 16.7 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04744.1 - 0.021 15.3 0.2 0.049 14.2 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04744.1 - 0.1 13.0 0.0 0.29 11.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04744.1 - 0.15 12.5 0.0 2.8 8.5 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain GFA PF04828.9 EFX04745.1 - 7.8e-13 48.1 0.2 1.3e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Cys_rich_CWC PF14375.1 EFX04745.1 - 0.51 10.2 6.8 0.23 11.4 2.3 1.9 2 0 0 2 2 2 0 Cysteine-rich CWC DUF2434 PF10361.4 EFX04746.1 - 6.7e-120 399.6 8.7 8.6e-120 399.2 6.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Ribosomal_L19e PF01280.15 EFX04747.1 - 1.1e-60 203.7 7.7 1.1e-60 203.7 5.3 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e Endonuc_Holl PF10107.4 EFX04747.1 - 1.3 8.6 5.7 2.2 7.9 3.9 1.4 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Fungal_trans PF04082.13 EFX04748.1 - 1.5e-22 79.7 0.0 3.5e-22 78.5 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04748.1 - 8.1e-10 38.4 10.1 1.9e-09 37.2 7.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HECT_2 PF09814.4 EFX04749.1 - 1.6e-44 152.0 0.0 2.4e-43 148.2 0.0 2.1 1 1 1 2 2 2 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding SNF2_N PF00176.18 EFX04749.1 - 2.8e-33 114.9 0.0 1.8e-29 102.4 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX04749.1 - 0.0029 17.4 0.1 0.0063 16.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX04749.1 - 0.0087 15.9 0.0 2.6 7.8 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DUF655 PF04919.7 EFX04749.1 - 0.039 13.6 0.1 0.078 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF655) Peptidase_M48 PF01435.13 EFX04750.1 - 2.6e-49 167.8 0.0 4.5e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 Ribosomal_L34 PF00468.12 EFX04750.1 - 1.7e-13 50.0 13.0 3.5e-13 48.9 9.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L34 DUF2201_N PF13203.1 EFX04750.1 - 0.09 11.9 0.4 0.23 10.6 0.2 1.6 1 0 0 1 1 1 0 Putative metallopeptidase domain Hamartin PF04388.7 EFX04751.1 - 0.11 11.0 0.1 0.13 10.9 0.1 1.0 1 0 0 1 1 1 0 Hamartin protein Hus1 PF04005.7 EFX04752.1 - 3.4e-66 223.1 0.0 4.9e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 Hus1-like protein zf-RING_2 PF13639.1 EFX04752.1 - 1.3e-07 31.3 0.7 2.6e-07 30.3 0.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFX04752.1 - 1.4e-05 24.6 0.3 8.3e-05 22.1 0.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX04752.1 - 0.00018 21.4 0.3 0.00018 21.4 0.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX04752.1 - 0.00035 20.1 0.5 0.00035 20.1 0.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFX04752.1 - 0.00043 20.3 1.4 0.00044 20.2 0.2 1.7 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFX04752.1 - 0.0071 16.0 0.1 0.0071 16.0 0.1 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 EFX04752.1 - 0.013 15.2 0.1 0.026 14.3 0.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 EFX04752.1 - 8.9 6.1 7.7 23 4.7 0.0 2.8 2 0 0 2 2 2 0 RING-type zinc-finger GTP_EFTU PF00009.22 EFX04753.1 - 1.4e-48 164.8 0.0 2.1e-48 164.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 EFX04753.1 - 2.5e-38 130.2 4.3 4.9e-38 129.3 3.0 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 EFX04753.1 - 9e-15 54.3 0.0 1.7e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 EFX04753.1 - 4.8e-06 26.3 0.0 2.5e-05 24.0 0.0 2.2 2 1 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 EFX04753.1 - 0.00013 21.9 0.1 0.00029 20.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX04753.1 - 0.00028 20.8 0.0 0.00059 19.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 EFX04753.1 - 0.00048 19.5 0.0 0.0013 18.0 0.0 1.6 2 0 0 2 2 2 1 Ras family SRPRB PF09439.5 EFX04753.1 - 0.0071 15.5 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Acetyltransf_7 PF13508.1 EFX04754.1 - 0.15 12.2 0.0 0.51 10.5 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pribosyltran PF00156.22 EFX04755.1 - 7.7e-15 54.7 0.0 1.6e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain FAD_binding_4 PF01565.18 EFX04755.1 - 5.6e-13 48.5 6.5 7.1e-13 48.2 3.3 2.1 2 0 0 2 2 2 1 FAD binding domain P-mevalo_kinase PF04275.9 EFX04755.1 - 2.7e-09 36.7 0.0 5e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Phosphomevalonate kinase UPRTase PF14681.1 EFX04755.1 - 6.6e-06 25.4 0.0 1.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 EFX04755.1 - 0.0051 16.1 0.0 0.036 13.3 0.0 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase BBE PF08031.7 EFX04755.1 - 0.011 15.5 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 Berberine and berberine like Amidase PF01425.16 EFX04756.1 - 5.7e-89 298.9 0.1 7.5e-89 298.5 0.1 1.1 1 0 0 1 1 1 1 Amidase Cmc1 PF08583.5 EFX04757.1 - 4e-19 68.1 1.8 4e-19 68.1 1.2 1.6 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 EFX04757.1 - 0.05 13.5 4.0 3.1 7.8 0.2 2.2 2 0 0 2 2 2 0 CHCH domain Pet191_N PF10203.4 EFX04757.1 - 0.071 13.1 1.5 1.4 9.0 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 TACC PF05010.9 EFX04758.1 - 0.037 13.7 0.2 0.04 13.6 0.2 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) PNPase PF03726.9 EFX04758.1 - 0.041 14.1 2.3 0.041 14.1 1.6 1.9 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF1151 PF06625.6 EFX04758.1 - 0.046 13.4 2.7 0.068 12.9 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) RNA_pol_Rpb4 PF03874.11 EFX04759.1 - 7e-25 87.3 0.4 8e-25 87.1 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb4 Pectate_lyase_2 PF06917.7 EFX04759.1 - 0.04 12.1 0.0 0.044 12.0 0.0 1.0 1 0 0 1 1 1 0 Periplasmic pectate lyase ATG13 PF10033.4 EFX04760.1 - 6.5e-61 205.7 1.6 1.4e-33 116.3 0.0 2.7 3 0 0 3 3 3 2 Autophagy-related protein 13 DUF4611 PF15387.1 EFX04760.1 - 8.8 6.5 10.1 3.6 7.7 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Beta-lactamase PF00144.19 EFX04762.1 - 2.9e-23 82.4 0.0 3.6e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase adh_short PF00106.20 EFX04763.1 - 4e-22 78.8 9.1 2.5e-21 76.3 6.3 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04763.1 - 4.1e-18 66.0 0.9 3.4e-17 63.0 0.7 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX04763.1 - 5.3e-09 36.0 2.0 5.3e-09 36.0 1.4 2.1 1 1 1 2 2 2 1 KR domain NAD_binding_10 PF13460.1 EFX04763.1 - 0.00032 20.7 0.5 0.00066 19.7 0.4 1.7 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EFX04763.1 - 0.00067 19.1 4.9 0.0099 15.3 3.4 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EFX04763.1 - 0.0088 14.9 0.1 0.015 14.1 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein TrkA_N PF02254.13 EFX04763.1 - 0.0088 16.0 0.3 0.015 15.2 0.2 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.14 EFX04763.1 - 0.011 14.5 0.1 0.016 13.9 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox PF00070.22 EFX04763.1 - 0.013 15.8 0.3 0.044 14.1 0.2 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 EFX04763.1 - 0.02 14.5 0.2 0.039 13.6 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.10 EFX04763.1 - 0.023 14.5 0.1 0.046 13.5 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_tranf_2_3 PF13641.1 EFX04763.1 - 0.026 14.3 0.1 0.045 13.5 0.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 THF_DHG_CYH_C PF02882.14 EFX04763.1 - 0.057 12.4 0.3 0.22 10.5 0.0 1.9 1 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_tran_WecB PF03808.8 EFX04763.1 - 0.082 12.3 0.3 0.25 10.7 0.2 1.7 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Methyltransf_26 PF13659.1 EFX04763.1 - 0.12 12.3 0.2 0.24 11.4 0.1 1.4 1 1 0 1 1 1 0 Methyltransferase domain Sec7 PF01369.15 EFX04765.1 - 3.6e-64 215.9 0.7 1.2e-63 214.2 0.1 2.2 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.2 EFX04765.1 - 8.3e-37 126.1 9.4 1.4e-29 102.6 0.2 3.8 2 1 1 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 EFX04765.1 - 2.8e-31 106.8 0.1 5.3e-30 102.7 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) TRAPP PF04051.11 EFX04766.1 - 1.6e-36 125.1 0.0 1.9e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Macro PF01661.16 EFX04767.1 - 5.8e-41 139.1 0.1 8.9e-41 138.5 0.1 1.3 1 0 0 1 1 1 1 Macro domain ADH_zinc_N PF00107.21 EFX04769.1 - 1e-15 57.4 0.2 1.5e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX04769.1 - 3e-09 37.8 0.2 1.2e-08 35.9 0.1 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX04769.1 - 3.6e-06 26.7 0.0 5.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.20 EFX04770.1 - 5.7e-11 42.5 0.3 9.5e-11 41.8 0.2 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 EFX04770.1 - 7.3e-05 22.7 0.1 0.00011 22.1 0.1 1.3 1 0 0 1 1 1 1 Acyl-carrier DUF1776 PF08643.5 EFX04771.1 - 3.1e-97 325.3 0.0 6e-97 324.3 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) BATS PF06968.8 EFX04774.1 - 1.3e-28 98.6 0.2 3.5e-28 97.2 0.0 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 EFX04774.1 - 2e-12 47.5 0.0 3.9e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily CoA_transf_3 PF02515.12 EFX04776.1 - 4.5e-26 91.2 0.0 7.3e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 CoA-transferase family III Dioxygenase_C PF00775.16 EFX04776.1 - 2.2e-23 82.4 0.1 4.4e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 EFX04776.1 - 1.5e-12 47.3 0.1 3.6e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 EFX04776.1 - 5e-05 23.2 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CHORD PF04968.7 EFX04776.1 - 0.02 15.1 0.5 0.057 13.6 0.4 1.7 1 0 0 1 1 1 0 CHORD NMO PF03060.10 EFX04777.1 - 5.3e-61 206.5 0.1 7.2e-61 206.1 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFX04777.1 - 3.8e-09 35.9 0.0 0.0013 17.7 0.4 2.2 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EFX04777.1 - 0.017 13.9 0.3 0.027 13.3 0.2 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Nitro_FeMo-Co PF02579.12 EFX04777.1 - 0.018 15.0 0.1 0.043 13.8 0.1 1.5 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor Nuc_sug_transp PF04142.10 EFX04778.1 - 1.7e-75 253.3 5.9 2.5e-75 252.7 4.1 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 EFX04778.1 - 4.7e-10 38.8 7.7 3.6e-06 26.1 1.1 2.2 2 0 0 2 2 2 2 UAA transporter family TPT PF03151.11 EFX04778.1 - 8.1e-08 32.0 19.7 1.5e-06 27.9 0.8 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family EmrE PF13536.1 EFX04778.1 - 3.8e-06 27.0 13.7 0.00011 22.3 0.9 2.5 2 0 0 2 2 2 2 Multidrug resistance efflux transporter EamA PF00892.15 EFX04778.1 - 0.00024 21.1 4.0 0.00024 21.1 2.7 2.9 2 1 0 2 2 2 1 EamA-like transporter family UPF0546 PF10639.4 EFX04778.1 - 0.089 12.6 9.5 0.89 9.3 0.6 2.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0546 FUSC_2 PF13515.1 EFX04778.1 - 0.15 12.0 12.3 2.5 8.0 0.0 3.2 2 1 1 3 3 3 0 Fusaric acid resistance protein-like DCA16 PF15349.1 EFX04778.1 - 0.15 11.3 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 Abhydrolase_3 PF07859.8 EFX04779.1 - 3.8e-43 147.5 0.1 4.8e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EFX04779.1 - 8.3e-07 28.0 0.0 1.3e-06 27.4 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EFX04779.1 - 0.0046 16.7 0.0 0.0065 16.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX04779.1 - 0.12 11.6 0.0 0.26 10.4 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Mid2 PF04478.7 EFX04780.1 - 0.0021 17.4 0.0 0.0054 16.1 0.0 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Shisa PF13908.1 EFX04780.1 - 0.009 16.2 1.1 0.009 16.2 0.7 2.1 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator Syndecan PF01034.15 EFX04780.1 - 0.0091 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain SKG6 PF08693.5 EFX04780.1 - 0.017 14.4 0.9 0.038 13.3 0.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF1183 PF06682.7 EFX04780.1 - 0.036 13.6 0.9 0.058 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) DUF4311 PF14188.1 EFX04780.1 - 0.071 12.6 0.3 0.46 9.9 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4311) GPP34 PF05719.6 EFX04781.1 - 3.2e-65 220.0 2.1 4e-65 219.7 1.5 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) TRP PF06011.7 EFX04783.1 - 2.3e-150 501.0 32.8 2.9e-150 500.6 22.7 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFX04783.1 - 1.1e-42 145.4 1.3 1.8e-42 144.7 0.9 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.10 EFX04783.1 - 0.0027 17.9 0.1 0.005 17.0 0.0 1.4 1 0 0 1 1 1 1 ML domain TauD PF02668.11 EFX04784.1 - 2.5e-46 158.4 0.0 2.9e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PigN PF04987.9 EFX04785.1 - 5.4e-159 529.5 28.9 7.2e-159 529.1 20.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 EFX04785.1 - 6.1e-13 48.8 0.2 1.6e-10 40.9 0.0 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EFX04785.1 - 4.3e-09 36.0 0.1 6.9e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 EFX04785.1 - 0.00022 20.6 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Apolipoprotein PF01442.13 EFX04786.1 - 1.1e-05 25.0 8.1 2.4e-05 23.9 5.6 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain MRP-S31 PF15433.1 EFX04786.1 - 0.003 17.0 0.4 0.0036 16.7 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 DUF883 PF05957.8 EFX04786.1 - 0.0098 16.2 16.9 0.8 10.1 3.6 2.7 1 1 0 2 2 2 2 Bacterial protein of unknown function (DUF883) FAM92 PF06730.6 EFX04786.1 - 0.16 11.2 2.1 0.17 11.2 0.9 1.4 1 1 0 1 1 1 0 FAM92 protein ARGLU PF15346.1 EFX04786.1 - 0.49 10.1 5.8 0.66 9.7 3.8 1.3 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 Ribosomal_L15e PF00827.12 EFX04788.1 - 4e-92 307.0 11.8 4.5e-92 306.8 8.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 He_PIG PF05345.7 EFX04789.1 - 5e-12 45.6 10.8 0.00018 21.4 0.2 4.9 4 0 0 4 4 4 3 Putative Ig domain TMEM154 PF15102.1 EFX04789.1 - 0.0049 16.5 0.1 0.012 15.2 0.1 1.6 1 0 0 1 1 1 1 TMEM154 protein family gpUL132 PF11359.3 EFX04789.1 - 0.0091 15.3 2.2 0.023 14.0 1.5 1.6 1 0 0 1 1 1 1 Glycoprotein UL132 DUF4448 PF14610.1 EFX04789.1 - 0.013 15.0 0.1 0.039 13.4 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4448) Amnionless PF14828.1 EFX04789.1 - 0.47 8.8 0.0 0.82 8.0 0.0 1.3 1 0 0 1 1 1 0 Amnionless Aldo_ket_red PF00248.16 EFX04790.1 - 8.9e-51 172.3 0.0 1e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PLDc PF00614.17 EFX04791.1 - 1.3e-16 59.7 0.8 1.1e-07 31.4 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 EFX04791.1 - 4.1e-12 45.9 0.0 6.1e-09 35.6 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PX PF00787.19 EFX04791.1 - 0.00019 21.1 0.0 0.003 17.3 0.0 2.7 2 1 0 2 2 2 1 PX domain Ino80_Iec3 PF14612.1 EFX04792.1 - 7e-43 147.3 2.2 6.8e-42 144.0 1.5 2.7 1 1 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling EBP PF05241.7 EFX04793.1 - 7.8e-46 155.5 6.2 1.2e-45 154.9 4.3 1.2 1 0 0 1 1 1 1 Emopamil binding protein JSRP PF15312.1 EFX04793.1 - 0.02 14.8 0.1 0.038 13.9 0.1 1.5 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein GNVR PF13807.1 EFX04793.1 - 0.39 10.4 1.6 0.63 9.8 0.3 1.8 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase zf-H2C2_2 PF13465.1 EFX04794.1 - 0.00014 21.9 0.2 0.00014 21.9 0.1 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFX04794.1 - 0.0035 17.5 2.1 0.3 11.5 0.1 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger DUF1644 PF07800.7 EFX04794.1 - 0.028 14.2 0.5 0.063 13.1 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) zf-C2H2 PF00096.21 EFX04794.1 - 0.47 10.8 0.0 0.47 10.8 0.0 3.3 3 1 0 3 3 3 0 Zinc finger, C2H2 type Ribosomal_60s PF00428.14 EFX04794.1 - 2 8.8 11.6 0.74 10.2 1.1 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein LRR19-TM PF15176.1 EFX04794.1 - 8.5 6.1 8.5 3.7 7.2 0.0 3.0 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain Aa_trans PF01490.13 EFX04795.1 - 1.9e-25 89.2 30.8 2.2e-25 88.9 21.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2975 PF11188.3 EFX04795.1 - 10 5.8 18.6 0.033 13.9 3.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2975) IFRD PF05004.8 EFX04796.1 - 2.6e-20 72.7 2.3 5.3e-20 71.7 1.6 1.5 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Corona_nucleoca PF00937.13 EFX04796.1 - 0.0011 18.0 6.1 0.002 17.1 4.2 1.4 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein HEAT PF02985.17 EFX04796.1 - 0.026 14.5 0.3 1.7 8.9 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat MBF1 PF08523.5 EFX04797.1 - 2.9e-25 88.0 1.8 2.9e-25 88.0 1.2 2.0 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 EFX04797.1 - 1e-10 41.2 0.0 1.6e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 EFX04797.1 - 0.0002 21.5 0.0 0.00039 20.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.2 EFX04797.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_37 PF13744.1 EFX04797.1 - 0.097 12.4 0.1 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain His_Phos_2 PF00328.17 EFX04798.1 - 1.8e-41 142.6 0.0 2.6e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) HET PF06985.6 EFX04798.1 - 2.5e-18 66.5 0.0 5.9e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MIP-T3 PF10243.4 EFX04799.1 - 0.039 12.4 13.9 0.056 11.9 9.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PRP38_assoc PF12871.2 EFX04799.1 - 2.9 8.4 30.2 7.9 7.0 20.9 1.8 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SNF2_N PF00176.18 EFX04800.1 - 2.2e-11 43.1 2.9 9.4e-10 37.7 0.0 2.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain TCO89 PF10452.4 EFX04800.1 - 7.1e-08 31.8 0.0 7.1e-08 31.8 0.0 2.5 2 0 0 2 2 2 1 TORC1 subunit TCO89 Helicase_C PF00271.26 EFX04800.1 - 0.027 14.3 0.0 0.027 14.3 0.0 2.2 2 0 0 2 2 2 0 Helicase conserved C-terminal domain Band_3_cyto PF07565.8 EFX04800.1 - 0.31 10.5 12.1 0.73 9.2 8.4 1.6 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Dicty_REP PF05086.7 EFX04800.1 - 5.2 4.6 7.3 7.5 4.1 5.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4220 PF13968.1 EFX04800.1 - 8.9 5.2 7.1 8 5.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4220) DUF962 PF06127.6 EFX04801.1 - 2.1e-24 85.2 1.6 3e-24 84.7 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF962) 2-oxoacid_dh PF00198.18 EFX04802.1 - 5.2e-74 248.4 0.1 7e-74 247.9 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EFX04802.1 - 1.5e-16 59.7 0.2 3e-16 58.8 0.2 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 EFX04802.1 - 9e-10 38.0 0.4 2.6e-09 36.5 0.3 1.8 1 0 0 1 1 1 1 e3 binding domain DUF3614 PF12267.3 EFX04802.1 - 0.0046 17.2 0.3 0.011 16.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3614) Ribosomal_60s PF00428.14 EFX04802.1 - 0.99 9.8 24.8 0.24 11.8 4.0 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein PRiA4_ORF3 PF07929.6 EFX04803.1 - 3e-15 56.1 0.1 3.7e-15 55.7 0.1 1.0 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein p450 PF00067.17 EFX04804.1 - 5.4e-65 219.7 0.0 9.9e-65 218.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 KilA-N PF04383.8 EFX04805.1 - 0.00022 20.8 0.0 0.003 17.1 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain Phage_holin_6 PF10746.4 EFX04806.1 - 0.038 13.7 0.1 0.16 11.6 0.0 2.1 1 1 1 2 2 2 0 Phage holin family 6 Ala_racemase_N PF01168.15 EFX04807.1 - 1.6e-37 129.2 0.2 2.1e-37 128.8 0.1 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain F-box-like PF12937.2 EFX04809.1 - 0.038 13.7 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 F-box-like Uds1 PF15456.1 EFX04810.1 - 3.8e-44 149.6 5.4 3.8e-44 149.6 3.8 7.7 6 1 2 8 8 8 2 Up-regulated During Septation DASH_Dam1 PF08653.5 EFX04810.1 - 3.2 7.5 9.2 2.6 7.8 0.0 5.2 7 0 0 7 7 7 0 DASH complex subunit Dam1 CTP_transf_2 PF01467.21 EFX04811.1 - 5.3e-17 62.3 0.0 3.7e-14 53.0 0.0 2.6 2 0 0 2 2 2 2 Cytidylyltransferase Zip PF02535.17 EFX04813.1 - 9.3e-45 152.9 1.2 1.6e-44 152.1 0.8 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter ATP_sub_h PF10775.4 EFX04814.1 - 1.9e-24 85.1 0.9 2.7e-24 84.6 0.6 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.6 EFX04814.1 - 0.038 13.8 0.1 0.067 13.1 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 CBS PF00571.23 EFX04815.1 - 1e-28 98.8 5.7 4.4e-12 45.5 0.1 4.2 4 0 0 4 4 4 4 CBS domain UPRTase PF14681.1 EFX04816.1 - 6.6e-33 113.6 0.0 1.1e-32 112.9 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.13 EFX04816.1 - 3.5e-31 108.2 0.0 2.3e-17 63.2 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 EFX04816.1 - 2.1e-07 31.8 0.0 5.3e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain CPT PF07931.7 EFX04816.1 - 1.8e-06 27.6 0.0 5.6e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.22 EFX04816.1 - 0.0034 17.6 0.1 0.018 15.3 0.0 2.2 3 0 0 3 3 3 1 ABC transporter AAA_18 PF13238.1 EFX04816.1 - 0.0052 17.0 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFX04816.1 - 0.0086 15.9 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.12 EFX04816.1 - 0.01 15.6 0.4 0.029 14.2 0.3 1.8 1 1 0 1 1 1 0 Domain of unknown function DUF87 Zeta_toxin PF06414.7 EFX04816.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 EFX04816.1 - 0.041 13.8 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain PAXNEB PF05625.6 EFX04816.1 - 0.058 12.2 0.0 0.072 11.9 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein AAA_22 PF13401.1 EFX04816.1 - 0.059 13.5 0.0 0.38 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EFX04816.1 - 0.059 12.9 0.0 0.53 9.8 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA PF00004.24 EFX04816.1 - 0.09 12.9 0.0 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 EFX04816.1 - 0.11 11.9 0.0 4 6.8 0.0 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 EFX04816.1 - 0.12 11.5 0.0 0.25 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MobB PF03205.9 EFX04816.1 - 0.12 12.0 0.0 0.34 10.6 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EFX04816.1 - 0.13 11.7 0.3 0.3 10.5 0.2 1.7 1 1 0 1 1 1 0 AAA-like domain Sulfate_transp PF00916.15 EFX04818.1 - 4.8e-75 252.1 6.1 9.3e-75 251.2 4.2 1.5 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EFX04818.1 - 1.2e-31 108.1 3.1 1.2e-31 108.1 2.1 2.7 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EFX04818.1 - 2.1e-09 36.7 0.0 4.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 EFX04818.1 - 0.12 12.4 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 STAS domain SNN_transmemb PF09049.5 EFX04818.1 - 5.9 6.6 8.7 0.78 9.4 0.8 3.0 2 0 0 2 2 2 0 Stannin transmembrane Glyco_hydro_61 PF03443.9 EFX04819.1 - 2.7e-46 158.1 0.0 3.5e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 TPT PF03151.11 EFX04821.1 - 1.4e-31 109.1 15.1 1.7e-31 108.9 7.5 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 EFX04821.1 - 2.3e-05 24.4 23.6 0.0064 16.5 1.5 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 EFX04821.1 - 0.00029 19.8 16.3 0.00056 18.9 11.3 1.4 1 0 0 1 1 1 1 UAA transporter family Histidinol_dh PF00815.15 EFX04822.1 - 9.9e-179 594.2 5.5 1.3e-178 593.8 3.8 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.13 EFX04822.1 - 7.7e-23 79.9 0.0 1.4e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 EFX04822.1 - 1.2e-09 38.3 0.2 4.2e-09 36.5 0.1 2.0 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase Mito_carr PF00153.22 EFX04823.1 - 1.1e-68 227.0 0.3 2e-23 81.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Snf7 PF03357.16 EFX04824.1 - 1.5e-15 56.9 4.7 1.5e-15 56.9 3.3 2.0 2 0 0 2 2 2 1 Snf7 DUF4611 PF15387.1 EFX04824.1 - 0.51 10.5 3.6 1.3 9.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CHCH PF06747.8 EFX04825.1 - 3.9e-06 26.6 6.5 5.9e-06 26.0 4.5 1.3 1 0 0 1 1 1 1 CHCH domain GCK PF07802.6 EFX04825.1 - 0.016 15.2 1.7 0.039 14.0 1.2 1.6 1 0 0 1 1 1 0 GCK domain FAD_binding_6 PF00970.19 EFX04826.1 - 3.9e-09 36.5 0.0 8.3e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EFX04826.1 - 0.00018 21.4 0.0 0.00042 20.2 0.0 1.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EFX04826.1 - 0.00078 19.9 0.0 0.0021 18.5 0.0 1.8 1 1 1 2 2 2 1 Oxidoreductase NAD-binding domain WD40 PF00400.27 EFX04827.1 - 1.4e-44 148.4 7.4 2.1e-08 33.7 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat HemY_N PF07219.8 EFX04827.1 - 0.074 12.6 1.5 0.12 11.9 0.1 2.0 1 1 1 2 2 2 0 HemY protein N-terminus COX5B PF01215.14 EFX04828.1 - 1.1e-36 125.4 0.0 1.5e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb DUF4604 PF15377.1 EFX04829.1 - 2.3e-28 99.4 12.6 4.6e-28 98.4 8.8 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4604) GAGA_bind PF06217.7 EFX04829.1 - 0.11 12.4 3.4 0.12 12.2 2.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4585 PF15232.1 EFX04830.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4585) NAD_binding_8 PF13450.1 EFX04831.1 - 4.8e-08 32.9 0.1 1.3e-07 31.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFX04831.1 - 7.5e-08 31.8 0.0 1.1e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.2 EFX04831.1 - 9.7e-06 24.9 0.0 1.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX04831.1 - 1e-05 24.5 0.6 1.7e-05 23.8 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX04831.1 - 2.5e-05 23.3 0.2 0.00022 20.2 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX04831.1 - 0.00011 20.8 0.0 0.00017 20.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 EFX04831.1 - 0.00014 21.0 0.0 0.00043 19.4 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.1 EFX04831.1 - 0.00014 21.9 0.1 0.00036 20.6 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX04831.1 - 0.00018 21.4 0.1 0.00045 20.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX04831.1 - 0.00089 19.6 0.6 0.0027 18.0 0.4 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFX04831.1 - 0.0012 17.9 0.6 0.002 17.2 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 EFX04831.1 - 0.0019 17.1 0.1 0.0031 16.4 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_7 PF13241.1 EFX04831.1 - 0.0087 16.2 0.1 0.031 14.5 0.0 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.7 EFX04831.1 - 0.011 14.7 0.2 0.022 13.6 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein IlvN PF07991.7 EFX04831.1 - 0.014 14.8 0.1 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain AlaDh_PNT_C PF01262.16 EFX04831.1 - 0.02 14.4 0.1 0.058 12.9 0.0 1.7 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Aldo_ket_red PF00248.16 EFX04832.1 - 3.6e-43 147.4 0.0 4.5e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ketoacyl-synt PF00109.21 EFX04833.1 - 2.2e-56 191.1 0.1 2.2e-56 191.1 0.0 2.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EFX04833.1 - 8.7e-32 110.7 1.1 2.5e-31 109.2 0.8 1.8 1 0 0 1 1 1 1 Acyl transferase domain Lactonase PF10282.4 EFX04833.1 - 4.1e-27 95.1 1.0 7.8e-27 94.2 0.7 1.4 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller NAD_binding_4 PF07993.7 EFX04833.1 - 7.8e-27 93.7 0.0 1.4e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.17 EFX04833.1 - 5.2e-25 87.6 0.1 6.6e-24 84.0 0.0 2.6 1 1 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 EFX04833.1 - 1.3e-09 38.1 0.1 3.8e-09 36.6 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 EFX04833.1 - 1e-06 28.3 0.1 9.5e-06 25.2 0.0 2.6 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 EFX04833.1 - 0.00028 20.7 0.1 0.0015 18.4 0.1 2.3 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus SGL PF08450.7 EFX04833.1 - 0.0027 17.1 0.3 0.012 15.0 0.0 2.1 3 0 0 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region Polysacc_synt_2 PF02719.10 EFX04833.1 - 0.12 11.2 0.0 0.3 9.9 0.0 1.7 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 EFX04833.1 - 0.25 9.9 0.0 1.4 7.5 0.0 2.0 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family GFA PF04828.9 EFX04835.1 - 1.7e-11 43.9 2.8 2.4e-11 43.4 2.0 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Collagen PF01391.13 EFX04836.1 - 0.011 15.2 9.3 0.025 14.1 6.5 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Serglycin PF04360.7 EFX04836.1 - 0.088 12.5 1.7 0.19 11.4 1.2 1.5 1 0 0 1 1 1 0 Serglycin zf-C2H2_jaz PF12171.3 EFX04837.1 - 6.4e-06 26.1 3.3 9.6e-06 25.5 2.3 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX04837.1 - 0.0011 19.0 0.5 0.0018 18.4 0.3 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 EFX04837.1 - 0.11 12.9 0.7 0.18 12.2 0.5 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX04837.1 - 0.11 12.8 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EFX04837.1 - 0.12 12.4 0.6 0.18 11.9 0.4 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Response_reg PF00072.19 EFX04838.1 - 6.9e-19 67.9 0.0 1.9e-12 47.1 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain Ycf66_N PF07444.6 EFX04839.1 - 2.1 8.1 5.9 6.5 6.5 0.4 2.8 3 0 0 3 3 3 0 Ycf66 protein N-terminus TT_ORF2 PF02957.10 EFX04840.1 - 7.2 7.3 14.8 6.6 7.4 3.0 2.5 1 1 2 3 3 3 0 TT viral ORF2 DUF4111 PF13427.1 EFX04841.1 - 0.0084 15.9 0.0 0.025 14.4 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4111) Metaviral_G PF09595.5 EFX04843.1 - 2.9 7.5 23.0 5.2 6.6 16.0 1.3 1 1 0 1 1 1 0 Metaviral_G glycoprotein TFIIA PF03153.8 EFX04843.1 - 2.9 7.6 9.2 3.4 7.4 6.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NT-C2 PF10358.4 EFX04844.1 - 3.8e-24 84.7 0.0 1.6e-20 73.0 0.0 2.2 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins Abhydrolase_4 PF08386.5 EFX04845.1 - 1.3e-16 60.3 0.0 3e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 EFX04845.1 - 8e-14 51.7 0.0 2.8e-11 43.4 0.0 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX04845.1 - 8.4e-11 42.1 2.4 3e-10 40.3 1.6 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX04845.1 - 0.00073 19.3 0.2 0.0072 16.0 0.2 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1664 PF07889.7 EFX04845.1 - 0.26 11.0 0.4 0.51 10.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Fungal_trans PF04082.13 EFX04846.1 - 3.9e-09 35.7 0.1 8.6e-09 34.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04846.1 - 1.4e-06 28.1 9.7 3e-06 27.0 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactonase PF10282.4 EFX04847.1 - 0.001 18.2 0.2 0.15 11.1 0.0 2.9 1 1 2 3 3 3 2 Lactonase, 7-bladed beta-propeller Peptidase_C25_C PF03785.9 EFX04847.1 - 0.14 11.9 5.7 1.5 8.6 0.1 3.0 1 1 1 2 2 2 0 Peptidase family C25, C terminal ig-like domain DNA_pol_B PF00136.16 EFX04849.1 - 7.2e-83 278.9 0.0 1.1e-82 278.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EFX04849.1 - 9.8e-11 41.0 0.0 5.3e-07 28.8 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain Bac_luciferase PF00296.15 EFX04850.1 - 2.4e-71 240.3 0.4 3e-71 240.0 0.3 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase FAD_binding_3 PF01494.14 EFX04851.1 - 1.5e-70 238.0 0.4 2.8e-70 237.1 0.3 1.5 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.7 EFX04851.1 - 5.1e-29 101.0 0.0 9e-29 100.2 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain NAD_binding_8 PF13450.1 EFX04851.1 - 1.4e-05 24.9 0.6 0.00021 21.2 0.0 3.0 3 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EFX04851.1 - 6.7e-05 21.5 0.0 0.0001 20.9 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.19 EFX04851.1 - 9.8e-05 21.4 1.2 0.00055 18.9 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 EFX04851.1 - 0.00046 19.3 0.4 0.0014 17.7 0.1 1.8 1 1 1 2 2 2 1 Thi4 family Pyr_redox PF00070.22 EFX04851.1 - 0.00052 20.3 0.1 0.0011 19.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX04851.1 - 0.00059 19.7 0.0 0.0015 18.4 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EFX04851.1 - 0.0026 16.7 0.2 0.0044 16.0 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 EFX04851.1 - 0.0027 16.6 0.4 0.0057 15.5 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 EFX04851.1 - 0.004 17.2 0.0 0.0088 16.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.1 EFX04851.1 - 0.0043 17.3 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 XdhC Rossmann domain AlaDh_PNT_C PF01262.16 EFX04851.1 - 0.0063 16.0 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.17 EFX04851.1 - 0.011 14.6 0.1 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX04851.1 - 0.014 14.4 0.5 0.033 13.2 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EFX04851.1 - 0.017 13.7 0.0 0.056 12.0 0.0 1.8 2 0 0 2 2 2 0 Tryptophan halogenase UDPG_MGDP_dh_N PF03721.9 EFX04851.1 - 0.023 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 EFX04851.1 - 0.066 12.8 0.1 0.14 11.7 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDI PF00996.13 EFX04851.1 - 0.097 10.9 0.0 0.18 10.0 0.0 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor Sugar_tr PF00083.19 EFX04852.1 - 1.1e-75 255.0 19.0 1.3e-75 254.7 13.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04852.1 - 5.1e-15 55.0 22.7 5.1e-15 55.0 15.7 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily TPR_9 PF13371.1 EFX04852.1 - 0.0063 16.3 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX04852.1 - 0.027 15.1 0.0 0.057 14.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.1 EFX04852.1 - 0.14 12.5 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat MgtE PF01769.11 EFX04852.1 - 0.43 10.8 0.1 0.43 10.8 0.0 3.2 2 1 1 3 3 3 0 Divalent cation transporter Polysacc_deac_1 PF01522.16 EFX04853.1 - 6.4e-22 77.4 0.0 1.4e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2194 PF09960.4 EFX04853.1 - 0.058 11.4 0.0 0.093 10.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2194) Surp PF01805.15 EFX04854.1 - 8.8e-36 121.3 0.3 5.9e-17 61.0 0.0 2.3 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.3 EFX04854.1 - 4.3e-22 78.7 2.6 6e-22 78.2 1.8 1.1 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Amidohydro_1 PF01979.15 EFX04857.1 - 8.3e-35 120.9 0.5 1.2e-34 120.5 0.3 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 EFX04857.1 - 6.8e-06 26.3 6.5 4e-05 23.7 4.5 2.1 1 1 0 1 1 1 1 Amidohydrolase DUF4537 PF15057.1 EFX04857.1 - 0.081 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Ank_2 PF12796.2 EFX04858.1 - 2.9e-37 126.8 2.8 8.1e-14 51.7 0.1 3.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX04858.1 - 4.5e-29 98.7 8.2 9.6e-05 22.0 0.1 7.1 5 2 2 7 7 7 5 Ankyrin repeat MFS_1 PF07690.11 EFX04858.1 - 6.3e-29 100.7 28.4 1e-28 100.1 19.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Ank_4 PF13637.1 EFX04858.1 - 8.4e-24 83.4 0.3 7.5e-07 29.5 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX04858.1 - 4.9e-21 72.7 1.8 0.018 15.2 0.0 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 EFX04858.1 - 1.5e-20 72.7 0.6 0.0025 17.9 0.0 6.6 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Sugar_tr PF00083.19 EFX04858.1 - 1.4e-12 46.9 9.4 1.4e-12 46.9 6.5 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 EFX04858.1 - 0.00089 17.5 2.4 0.0015 16.7 1.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) NACHT PF05729.7 EFX04858.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 EFX04858.1 - 0.092 12.8 0.3 1.4 9.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain Fungal_trans PF04082.13 EFX04860.1 - 5.7e-27 94.2 2.0 9.5e-27 93.4 1.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04860.1 - 2.2e-08 33.8 12.2 4.4e-08 32.9 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ring_hydroxyl_A PF00848.14 EFX04861.1 - 8.7e-33 113.7 2.8 3.7e-32 111.6 1.9 1.9 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.21 EFX04861.1 - 2.1e-12 46.4 0.1 4.3e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain HET PF06985.6 EFX04862.1 - 6e-24 84.7 0.0 1.3e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF1088 PF06469.6 EFX04862.1 - 0.019 14.3 0.2 0.032 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) Zn_clus PF00172.13 EFX04863.1 - 1.7e-05 24.6 10.0 1.7e-05 24.6 7.0 2.9 3 1 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain UBA_4 PF14555.1 EFX04864.1 - 7.9e-10 38.1 0.1 1.9e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 EFX04864.1 - 0.0007 19.6 0.0 0.0022 18.0 0.0 1.9 1 1 0 1 1 1 1 UBX domain Serglycin PF04360.7 EFX04864.1 - 0.052 13.2 0.4 0.11 12.2 0.3 1.5 1 0 0 1 1 1 0 Serglycin Fungal_trans_2 PF11951.3 EFX04865.1 - 0.03 12.9 0.1 0.12 10.9 0.0 1.8 2 0 0 2 2 2 0 Fungal specific transcription factor domain Bac_rhamnosid PF05592.6 EFX04866.1 - 6.4e-14 51.0 4.1 1.3e-13 49.9 1.6 2.3 1 1 1 2 2 2 1 Bacterial alpha-L-rhamnosidase Trehalase PF01204.13 EFX04866.1 - 1.1e-07 30.9 0.0 1.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Trehalase FMN_dh PF01070.13 EFX04867.1 - 3e-87 292.7 0.5 1.4e-47 162.3 0.2 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase His_biosynth PF00977.16 EFX04867.1 - 0.04 13.1 0.3 0.78 8.9 0.0 2.5 1 1 1 2 2 2 0 Histidine biosynthesis protein IMPDH PF00478.20 EFX04867.1 - 0.041 12.7 0.0 0.077 11.8 0.0 1.4 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.16 EFX04867.1 - 0.056 12.3 0.1 0.33 9.8 0.0 2.0 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase ThiG PF05690.9 EFX04867.1 - 0.081 11.9 0.1 5.3 6.0 0.0 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG IGPS PF00218.16 EFX04867.1 - 0.11 11.5 0.0 2.6 7.0 0.0 2.1 1 1 1 2 2 2 0 Indole-3-glycerol phosphate synthase T_cell_tran_alt PF15128.1 EFX04867.1 - 0.11 11.9 0.1 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 T-cell leukemia translocation-altered Glu_synthase PF01645.12 EFX04867.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase Amidohydro_1 PF01979.15 EFX04869.1 - 1.6e-34 120.1 0.1 2.1e-34 119.6 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 EFX04869.1 - 2.5e-09 36.8 4.7 5.4e-07 29.1 0.0 2.9 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 EFX04869.1 - 4.6e-06 26.8 12.3 3e-05 24.2 8.5 2.2 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 EFX04869.1 - 6.5e-05 22.6 0.1 0.00046 19.9 0.0 2.3 2 0 0 2 2 2 1 Amidohydrolase A_deaminase PF00962.17 EFX04869.1 - 0.0073 15.2 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase MFS_1 PF07690.11 EFX04872.1 - 2.1e-46 158.2 86.7 5.8e-39 133.8 39.9 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 EFX04873.1 - 1.9e-15 56.4 20.8 1.9e-15 56.4 14.4 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFX04873.1 - 2.3e-14 53.1 1.2 2.3e-14 53.1 0.9 2.1 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 OATP PF03137.15 EFX04873.1 - 0.013 13.6 6.3 0.032 12.2 0.0 2.6 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family SET PF00856.23 EFX04875.1 - 9.8e-19 68.2 0.1 9.8e-19 68.2 0.1 3.9 4 1 0 4 4 4 1 SET domain Mito_carr PF00153.22 EFX04876.1 - 1.2e-70 233.2 2.6 4.7e-24 83.9 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_42 PF02449.10 EFX04876.1 - 0.18 10.8 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase HEAT_2 PF13646.1 EFX04877.1 - 3.3e-12 46.5 8.9 7.2e-07 29.3 1.6 3.2 3 2 1 4 4 4 3 HEAT repeats HEAT PF02985.17 EFX04877.1 - 0.00037 20.3 2.3 1.7 8.9 0.1 3.9 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.1 EFX04877.1 - 0.019 15.4 8.9 2.7 8.5 0.1 4.7 4 1 1 5 5 5 0 HEAT-like repeat DUF2435 PF10363.4 EFX04877.1 - 0.046 13.6 0.1 6.5 6.7 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2435) Cohesin_HEAT PF12765.2 EFX04877.1 - 6 6.9 6.4 0.83 9.6 0.2 2.6 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Tir_receptor_N PF07490.6 EFX04878.1 - 0.03 13.9 0.0 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus Phage_Capsid_P3 PF09018.6 EFX04878.1 - 0.08 11.5 0.0 0.093 11.2 0.0 1.1 1 0 0 1 1 1 0 P3 major capsid protein MFS_1 PF07690.11 EFX04879.1 - 4.4e-28 98.0 26.3 4.4e-28 98.0 18.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EFX04880.1 - 5.2e-22 78.0 47.2 3e-21 75.5 28.9 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX04880.1 - 1e-14 53.6 27.3 1.9e-14 52.7 18.9 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFX04880.1 - 1e-07 30.9 11.9 1e-07 30.9 8.2 2.9 3 1 1 4 4 4 2 Sugar (and other) transporter Neurensin PF14927.1 EFX04880.1 - 0.17 11.2 1.5 0.56 9.5 0.1 2.5 3 0 0 3 3 3 0 Neurensin Caps_synth_CapC PF14102.1 EFX04880.1 - 0.75 9.9 18.5 0.48 10.5 4.2 3.2 3 1 0 3 3 3 0 Capsule biosynthesis CapC Glycos_transf_1 PF00534.15 EFX04881.1 - 4.6e-13 48.9 0.0 1.5e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFX04881.1 - 0.00069 19.7 0.0 0.0034 17.5 0.0 2.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3492 PF11997.3 EFX04881.1 - 0.0066 16.0 0.0 0.021 14.3 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3492) Glyco_trans_1_2 PF13524.1 EFX04881.1 - 0.036 14.3 0.0 0.11 12.8 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferases group 1 SNARE PF05739.14 EFX04882.1 - 3.4e-18 65.0 2.3 6.7e-18 64.1 0.1 2.6 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 EFX04882.1 - 5.3e-13 49.0 4.5 5.5e-13 48.9 0.7 2.4 2 0 0 2 2 2 1 Syntaxin MCPsignal PF00015.16 EFX04882.1 - 0.019 14.4 1.7 0.019 14.4 1.2 2.6 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain His_Phos_1 PF00300.17 EFX04883.1 - 1.7e-26 93.2 0.0 2.6e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Transp_cyt_pur PF02133.10 EFX04884.1 - 1.9e-88 296.9 35.6 2.2e-88 296.7 24.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fumarate_red_D PF02313.12 EFX04884.1 - 0.029 14.2 2.4 0.87 9.4 0.1 3.1 2 0 0 2 2 2 0 Fumarate reductase subunit D Sugar_tr PF00083.19 EFX04885.1 - 9.7e-103 344.1 27.9 1.1e-102 343.9 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04885.1 - 3.4e-27 95.0 30.6 3.4e-27 95.0 21.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.2 EFX04885.1 - 0.00013 21.6 1.2 0.026 14.3 0.0 2.9 2 0 0 2 2 2 2 MFS_1 like family Epimerase PF01370.16 EFX04886.1 - 3.4e-33 115.0 0.0 5.9e-33 114.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 EFX04886.1 - 6.7e-15 54.7 0.1 1.5e-14 53.6 0.1 1.6 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit NAD_binding_4 PF07993.7 EFX04886.1 - 1.1e-08 34.2 0.2 6.4e-08 31.8 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 EFX04886.1 - 4.2e-07 28.9 0.5 1.7e-05 23.7 0.3 2.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EFX04886.1 - 1e-06 27.8 0.1 0.00015 20.8 0.2 3.2 3 1 0 3 3 3 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EFX04886.1 - 5.7e-05 23.0 0.0 0.00013 21.9 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX04886.1 - 0.00016 21.4 0.0 0.00036 20.2 0.0 1.5 1 0 0 1 1 1 1 KR domain UDPG_MGDP_dh_N PF03721.9 EFX04886.1 - 0.11 11.9 0.3 0.21 10.9 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain VCBS PF13517.1 EFX04887.1 - 0.016 15.5 0.0 0.019 15.3 0.0 1.1 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella ADIP PF11559.3 EFX04888.1 - 0.019 14.8 0.2 0.029 14.2 0.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Chloroplast_duf PF14476.1 EFX04888.1 - 0.14 10.9 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Petal formation-expressed FYVE PF01363.16 EFX04888.1 - 5.6 6.9 11.4 5.9 6.8 6.1 2.2 2 0 0 2 2 2 0 FYVE zinc finger AA_permease_2 PF13520.1 EFX04889.1 - 9.8e-44 149.5 54.7 1.2e-43 149.2 37.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX04889.1 - 9.6e-19 67.0 48.1 1.3e-18 66.6 33.3 1.1 1 0 0 1 1 1 1 Amino acid permease Sterol_MT_C PF08498.5 EFX04890.1 - 7.4e-27 93.0 0.2 1.2e-26 92.3 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 EFX04890.1 - 2.7e-21 75.8 0.0 5.2e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04890.1 - 1.6e-18 66.7 0.0 2.5e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX04890.1 - 6.5e-14 51.9 0.0 1.1e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX04890.1 - 8.3e-13 48.5 0.0 1.7e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04890.1 - 3.8e-12 46.7 0.0 9.1e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EFX04890.1 - 6e-12 45.2 0.1 9e-12 44.6 0.1 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 EFX04890.1 - 2.5e-10 39.8 0.0 4.2e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFX04890.1 - 4.3e-10 39.9 0.0 9.1e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX04890.1 - 2.6e-09 37.1 0.1 1.1e-08 35.1 0.0 2.0 2 1 0 2 2 1 1 Methyltransferase domain PCMT PF01135.14 EFX04890.1 - 6.1e-06 25.9 0.0 9.2e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.5 EFX04890.1 - 7.2e-06 25.6 0.1 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EFX04890.1 - 0.00013 21.4 0.0 0.00032 20.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EFX04890.1 - 0.00029 20.0 0.1 0.0048 16.0 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.13 EFX04890.1 - 0.0016 17.6 0.0 0.003 16.7 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase MetW PF07021.7 EFX04890.1 - 0.0053 16.1 0.0 0.025 13.9 0.0 1.9 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW Met_10 PF02475.11 EFX04890.1 - 0.0054 16.3 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein RrnaAD PF00398.15 EFX04890.1 - 0.0073 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase FAM177 PF14774.1 EFX04890.1 - 0.014 15.2 1.6 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 FAM177 family UPF0020 PF01170.13 EFX04890.1 - 0.016 14.8 0.1 0.043 13.3 0.0 1.7 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 DUF885 PF05960.6 EFX04890.1 - 0.031 13.4 1.7 0.045 12.9 1.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Methyltransf_24 PF13578.1 EFX04890.1 - 0.031 15.1 0.1 0.094 13.5 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_29 PF03141.11 EFX04890.1 - 0.04 12.2 0.0 0.066 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.1 EFX04890.1 - 0.092 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ISN1 PF06437.6 EFX04893.1 - 3.9e-143 477.0 0.0 7.5e-104 347.6 0.0 2.0 1 1 1 2 2 2 2 IMP-specific 5'-nucleotidase MerR PF00376.18 EFX04893.1 - 0.043 13.3 0.1 3.7 7.1 0.0 2.6 2 0 0 2 2 2 0 MerR family regulatory protein M20_dimer PF07687.9 EFX04895.1 - 9.1e-21 73.6 0.1 2.1e-20 72.5 0.1 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 EFX04895.1 - 4.2e-14 52.4 0.2 8.7e-14 51.4 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Fungal_trans PF04082.13 EFX04895.1 - 1.1e-12 47.3 0.4 2.4e-12 46.2 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain AA_permease_2 PF13520.1 EFX04896.1 - 2.5e-49 167.9 48.2 3e-49 167.7 33.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX04896.1 - 2.6e-16 59.0 42.6 5.3e-16 58.0 29.5 1.4 1 1 0 1 1 1 1 Amino acid permease PT PF04886.7 EFX04897.1 - 0.045 13.0 0.6 0.081 12.2 0.4 1.4 1 0 0 1 1 1 0 PT repeat Amidase PF01425.16 EFX04898.1 - 2.7e-100 336.2 0.0 3.2e-100 336.0 0.0 1.0 1 0 0 1 1 1 1 Amidase YwqJ-deaminase PF14431.1 EFX04898.1 - 0.082 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 YwqJ-like deaminase AATase PF07247.7 EFX04899.1 - 0.00041 19.0 0.0 0.33 9.4 0.0 2.0 2 0 0 2 2 2 2 Alcohol acetyltransferase Cuticle_1 PF08140.6 EFX04899.1 - 0.07 12.9 0.5 0.37 10.6 0.1 2.1 2 0 0 2 2 2 0 Crustacean cuticle protein repeat Methyltransf_23 PF13489.1 EFX04900.1 - 1.4e-12 47.6 0.0 1.8e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04900.1 - 5.3e-07 30.0 0.0 9.4e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04900.1 - 1.3e-05 25.5 0.0 0.00014 22.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04900.1 - 0.012 15.1 0.0 0.051 13.1 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 EFX04900.1 - 0.026 13.6 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 EFX04900.1 - 0.077 13.5 0.0 0.66 10.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain PALP PF00291.20 EFX04901.1 - 8.9e-46 156.5 0.2 1.2e-45 156.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF2191 PF09957.4 EFX04901.1 - 0.0054 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2191) Slu7 PF11708.3 EFX04902.1 - 3.2e-53 180.9 2.2 3.2e-53 180.9 1.5 1.7 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.18 EFX04902.1 - 4.3e-05 23.2 1.9 8.2e-05 22.3 1.3 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 EFX04902.1 - 0.023 14.3 1.0 0.045 13.4 0.7 1.5 1 0 0 1 1 1 0 Zinc knuckle Sigma70_r2 PF04542.9 EFX04902.1 - 2.7 7.6 6.8 0.11 12.0 0.5 1.8 2 0 0 2 2 2 0 Sigma-70 region 2 MFS_1 PF07690.11 EFX04904.1 - 3.1e-33 114.9 39.9 4.4e-33 114.4 23.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX04904.1 - 2.7e-11 42.7 8.0 2.7e-11 42.7 5.5 3.1 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.8 EFX04904.1 - 4.3e-05 21.9 4.9 9e-05 20.8 3.4 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4523 PF15023.1 EFX04904.1 - 0.21 11.1 0.0 0.42 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Rrn6 PF10214.4 EFX04905.1 - 1.6 6.6 7.2 2.6 6.0 5.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Glyco_hydro_3 PF00933.16 EFX04907.1 - 8e-75 251.5 0.0 1.8e-74 250.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX04907.1 - 9.7e-52 175.7 0.0 2.4e-51 174.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX04907.1 - 1e-18 67.0 0.1 2.1e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain WSC PF01822.14 EFX04910.1 - 6.6e-11 41.9 4.5 6.6e-11 41.9 3.1 4.6 5 1 0 5 5 5 1 WSC domain DUF3129 PF11327.3 EFX04911.1 - 6.2e-30 104.3 14.3 6.2e-30 104.3 9.9 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3129) GPI-anchored PF10342.4 EFX04911.1 - 3.5 8.1 6.9 0.24 11.8 0.6 2.2 3 0 0 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Pectate_lyase_3 PF12708.2 EFX04912.1 - 2.6e-18 66.9 17.9 6.2e-13 49.3 3.4 3.7 2 2 1 3 3 3 3 Pectate lyase superfamily protein DUF4246 PF14033.1 EFX04913.1 - 1.1e-137 459.7 0.0 5.4e-87 292.5 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF4246) Spherulin4 PF12138.3 EFX04914.1 - 2.4e-59 200.7 0.5 3e-59 200.4 0.4 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 Cation_ATPase_C PF00689.16 EFX04914.1 - 0.043 13.3 0.6 0.063 12.8 0.4 1.3 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus ABC2_membrane_2 PF12679.2 EFX04914.1 - 0.13 11.1 1.1 0.64 8.8 0.1 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein FAM209 PF15206.1 EFX04914.1 - 0.14 11.9 2.0 0.28 11.0 1.4 1.5 1 0 0 1 1 1 0 FAM209 family Synaptobrevin PF00957.16 EFX04914.1 - 1.6 8.4 5.4 3 7.5 3.7 1.4 1 0 0 1 1 1 0 Synaptobrevin NmrA PF05368.8 EFX04915.1 - 1.1e-15 57.5 0.0 1.5e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX04915.1 - 1.4e-11 44.7 0.1 2.8e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 EFX04915.1 - 0.0002 20.8 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 EFX04915.1 - 0.00056 19.8 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 EFX04915.1 - 0.00061 20.2 0.1 0.001 19.5 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.19 EFX04915.1 - 0.0016 18.7 0.1 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Ldh_1_N PF00056.18 EFX04915.1 - 0.044 13.6 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EFX04915.1 - 0.1 11.2 0.1 0.18 10.4 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.12 EFX04915.1 - 0.11 12.9 0.2 0.26 11.7 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GMC_oxred_N PF00732.14 EFX04917.1 - 1.4e-28 99.8 0.0 4.1e-28 98.3 0.0 1.8 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX04917.1 - 1e-17 64.7 0.3 2.3e-17 63.6 0.2 1.6 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EFX04917.1 - 1.9e-09 36.9 0.1 0.00062 18.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 EFX04917.1 - 2.9e-06 27.2 0.0 2.9e-06 27.2 0.0 2.4 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX04917.1 - 4e-06 25.9 3.6 0.00024 20.1 0.0 2.9 2 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX04917.1 - 5.3e-06 25.1 0.1 1.2e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.9 EFX04917.1 - 0.00011 22.1 0.0 0.0015 18.4 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX04917.1 - 0.00013 21.1 0.1 0.00026 20.1 0.1 1.5 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.2 EFX04917.1 - 0.00016 20.8 0.1 0.00034 19.8 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX04917.1 - 0.0011 19.1 0.0 0.11 12.5 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX04917.1 - 0.011 14.5 0.0 0.022 13.6 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.22 EFX04917.1 - 0.017 15.4 0.0 0.061 13.7 0.0 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EFX04917.1 - 0.026 13.5 0.1 0.045 12.8 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.7 EFX04917.1 - 0.034 13.0 0.0 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.1 EFX04917.1 - 0.041 13.6 0.0 0.092 12.5 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Zn_clus PF00172.13 EFX04918.1 - 1.7e-08 34.1 9.5 2.5e-08 33.6 6.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_2 PF12796.2 EFX04919.1 - 3.8e-33 113.6 2.0 1.9e-14 53.7 0.2 5.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 EFX04919.1 - 1.3e-28 97.3 14.2 1.5e-05 24.5 0.1 8.5 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.1 EFX04919.1 - 3.2e-25 87.5 9.8 2.5e-07 30.6 0.1 6.7 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX04919.1 - 3e-21 75.3 2.7 9.2e-05 22.8 0.0 6.4 5 2 1 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX04919.1 - 6.2e-20 69.3 5.5 0.0016 18.5 0.0 7.9 8 0 0 8 8 8 5 Ankyrin repeat F-box-like PF12937.2 EFX04919.1 - 0.00049 19.7 0.5 0.0012 18.4 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX04919.1 - 0.035 13.7 0.3 0.07 12.8 0.2 1.4 1 0 0 1 1 1 0 F-box domain RNase_P_p30 PF01876.11 EFX04919.1 - 0.037 13.2 0.1 0.14 11.3 0.0 1.8 2 0 0 2 2 2 0 RNase P subunit p30 FAD_binding_4 PF01565.18 EFX04920.1 - 3.3e-19 68.7 1.0 4.9e-19 68.1 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain Nitroreductase PF00881.19 EFX04922.1 - 9.6e-26 90.5 0.2 1.6e-25 89.8 0.1 1.4 1 0 0 1 1 1 1 Nitroreductase family 2OG-FeII_Oxy_3 PF13640.1 EFX04922.1 - 2.8e-10 40.5 0.0 6.6e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EFX04922.1 - 2.1e-06 27.2 0.0 6.6e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BTB PF00651.26 EFX04923.1 - 0.019 14.9 0.0 0.21 11.5 0.0 2.3 2 1 0 2 2 2 0 BTB/POZ domain DIOX_N PF14226.1 EFX04924.1 - 1.2e-23 83.8 0.0 1.8e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX04924.1 - 1.1e-19 70.5 0.0 1.8e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UspB PF10625.4 EFX04924.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Universal stress protein B (UspB) MFS_1 PF07690.11 EFX04925.1 - 0.025 13.3 0.0 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Glyco_trans_1_2 PF13524.1 EFX04925.1 - 0.13 12.5 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 EAF PF09816.4 EFX04927.1 - 7.8e-18 64.4 0.2 1.6e-17 63.3 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor DUF2500 PF10694.4 EFX04927.1 - 0.7 9.9 3.4 0.33 10.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Oxidored_FMN PF00724.15 EFX04928.1 - 3.7e-86 289.2 0.0 3.4e-85 286.0 0.0 1.9 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family NAD_binding_8 PF13450.1 EFX04929.1 - 1.3e-12 47.5 0.1 2.8e-12 46.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EFX04929.1 - 2.2e-08 33.6 0.2 3.4e-07 29.7 0.0 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 EFX04929.1 - 2.8e-08 33.2 0.0 5.6e-08 32.2 0.0 1.5 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.19 EFX04929.1 - 8.7e-08 31.4 0.0 1e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX04929.1 - 1.6e-06 27.2 0.2 6.7e-06 25.2 0.1 2.0 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.9 EFX04929.1 - 2.4e-05 22.9 0.1 2.4e-05 22.9 0.1 1.8 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_3 PF13738.1 EFX04929.1 - 3.1e-05 24.1 0.0 0.00018 21.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX04929.1 - 4.4e-05 23.4 0.1 0.00012 22.0 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX04929.1 - 0.00079 18.5 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 EFX04929.1 - 0.00088 19.6 0.0 0.0022 18.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EFX04929.1 - 0.00093 18.2 0.0 0.0014 17.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 EFX04929.1 - 0.0043 15.9 0.2 0.0064 15.3 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A DUF1320 PF07030.7 EFX04929.1 - 0.024 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) ApbA PF02558.11 EFX04929.1 - 0.067 12.6 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.1 EFX04929.1 - 0.095 12.4 1.1 0.23 11.2 0.0 2.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 EFX04929.1 - 0.1 11.6 0.1 0.2 10.6 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain HypA PF01155.14 EFX04930.1 - 0.15 11.7 0.2 0.32 10.6 0.1 1.5 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Auxin_repressed PF05564.7 EFX04930.1 - 0.4 11.2 3.7 11 6.6 0.5 3.1 2 1 1 3 3 3 0 Dormancy/auxin associated protein zinc_ribbon_2 PF13240.1 EFX04930.1 - 0.53 9.8 3.3 1.5 8.4 2.3 1.8 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.2 EFX04930.1 - 1.4 8.8 5.3 0.38 10.6 0.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon Nudix_N_2 PF14803.1 EFX04930.1 - 3.2 7.5 8.7 0.19 11.4 1.0 2.5 2 1 0 2 2 2 0 Nudix N-terminal zinc_ribbon_4 PF13717.1 EFX04930.1 - 7.7 6.3 7.5 0.52 10.0 0.2 2.7 3 0 0 3 3 3 0 zinc-ribbon domain Iso_dh PF00180.15 EFX04931.1 - 8.1e-85 284.8 0.0 9e-85 284.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DoxX_2 PF13564.1 EFX04931.1 - 0.017 15.1 0.9 0.041 13.8 0.7 1.6 1 0 0 1 1 1 0 DoxX-like family PhyH PF05721.8 EFX04932.1 - 1.1e-20 74.6 0.0 1.5e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.7 EFX04933.1 - 1.3e-113 379.6 0.0 1.6e-113 379.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.8 EFX04933.1 - 0.0064 16.5 0.1 0.75 9.7 0.1 2.8 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) PhyH PF05721.8 EFX04934.1 - 4e-14 53.1 0.1 4.1e-13 49.8 0.1 2.0 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.11 EFX04934.1 - 0.16 11.6 1.1 3.3 7.3 0.1 2.1 1 1 1 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family ANTH PF07651.11 EFX04935.1 - 4.1e-75 252.0 0.5 1.4e-74 250.3 0.0 2.1 2 0 0 2 2 2 1 ANTH domain I_LWEQ PF01608.12 EFX04935.1 - 2.5e-59 199.5 5.8 2.5e-59 199.5 4.0 5.5 3 2 1 6 6 6 2 I/LWEQ domain ENTH PF01417.15 EFX04935.1 - 0.00045 20.0 0.0 0.0015 18.3 0.0 1.9 1 0 0 1 1 1 1 ENTH domain Med15 PF09606.5 EFX04935.1 - 3.8 5.5 35.4 5.5 5.0 24.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Grp1_Fun34_YaaH PF01184.14 EFX04936.1 - 3.5e-31 108.1 22.1 4.7e-31 107.7 15.3 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ELF PF03317.8 EFX04936.1 - 0.47 9.7 4.4 0.73 9.0 3.0 1.2 1 0 0 1 1 1 0 ELF protein DUF3671 PF12420.3 EFX04936.1 - 3.1 7.8 6.2 0.51 10.3 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function PhyH PF05721.8 EFX04937.1 - 3.4e-29 102.3 0.0 5.5e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) IBN_N PF03810.14 EFX04938.1 - 6e-14 51.7 3.0 3.6e-11 42.8 0.0 4.3 5 0 0 5 5 5 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFX04938.1 - 3.7e-06 26.9 2.2 0.0048 16.8 0.0 4.1 4 0 0 4 4 4 2 Exportin 1-like protein HEAT_2 PF13646.1 EFX04938.1 - 0.0077 16.4 3.0 0.11 12.7 0.1 3.6 3 1 1 4 4 4 1 HEAT repeats TerB PF05099.8 EFX04938.1 - 0.052 13.2 5.5 0.67 9.6 0.0 3.3 3 0 0 3 3 3 0 Tellurite resistance protein TerB Cnd1 PF12717.2 EFX04938.1 - 0.054 13.3 1.1 0.55 10.0 0.1 3.0 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 EFX04938.1 - 0.061 13.4 0.1 0.91 9.7 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat Acetyltransf_1 PF00583.19 EFX04939.1 - 4.4e-11 42.6 0.1 6.6e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX04939.1 - 1.7e-09 37.6 0.1 3.1e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX04939.1 - 0.016 15.0 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AstA PF04958.7 EFX04939.1 - 0.061 11.7 0.0 0.085 11.2 0.0 1.1 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit FUSC PF04632.7 EFX04940.1 - 0.37 9.1 2.0 0.38 9.1 1.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family 4HBT_3 PF13622.1 EFX04941.1 - 1.4e-45 156.0 4.7 1.6e-45 155.8 3.3 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Fungal_trans PF04082.13 EFX04942.1 - 2.3e-09 36.5 0.3 3.4e-09 35.9 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04942.1 - 0.0016 18.2 2.7 0.0033 17.2 1.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallophos PF00149.23 EFX04943.1 - 4.7e-37 127.3 1.4 7.4e-37 126.6 1.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 EFX04943.1 - 1.2e-12 47.6 0.7 1e-11 44.7 0.1 2.8 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C PhoD PF09423.5 EFX04943.1 - 1.8e-11 43.2 0.4 1.7e-09 36.7 0.2 2.1 2 0 0 2 2 2 2 PhoD-like phosphatase fn3 PF00041.16 EFX04943.1 - 0.0054 16.8 0.1 0.016 15.2 0.1 1.8 1 0 0 1 1 1 1 Fibronectin type III domain GAT PF03127.9 EFX04944.1 - 3.9e-08 33.1 0.2 2.2e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 GAT domain VHS PF00790.14 EFX04944.1 - 5e-06 26.2 0.1 8.5e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 VHS domain PAT1 PF09770.4 EFX04944.1 - 0.65 8.1 11.0 0.88 7.7 7.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dynamin_N PF00350.18 EFX04945.1 - 5.4e-32 110.9 0.0 1.3e-31 109.7 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFX04945.1 - 3.5e-21 75.2 0.0 6.3e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Abhydrolase_6 PF12697.2 EFX04945.1 - 1.9e-08 34.4 1.8 1.9e-08 34.4 1.2 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family MMR_HSR1 PF01926.18 EFX04945.1 - 0.0022 17.9 0.0 0.053 13.4 0.0 3.1 3 1 0 3 3 3 1 50S ribosome-binding GTPase Miro PF08477.8 EFX04945.1 - 0.014 15.8 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein GED PF02212.13 EFX04945.1 - 0.083 12.7 0.9 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 Dynamin GTPase effector domain FeoB_N PF02421.13 EFX04945.1 - 0.088 12.0 0.0 14 4.8 0.0 2.6 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_21 PF13304.1 EFX04945.1 - 0.32 10.9 0.0 0.53 10.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.18 EFX04947.1 - 9.3e-29 100.6 31.0 3.9e-21 75.6 7.8 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EFX04947.1 - 4.5e-19 69.1 0.0 1.4e-14 54.5 0.0 3.2 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EFX04947.1 - 3e-06 26.6 0.0 0.3 10.2 0.0 3.1 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EFX04947.1 - 3.7e-05 23.8 0.0 0.69 9.8 0.0 3.4 2 1 0 3 3 3 1 AAA domain AAA_22 PF13401.1 EFX04947.1 - 0.0058 16.7 0.0 0.17 11.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX04947.1 - 0.018 15.8 0.0 0.042 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EFX04947.1 - 0.035 13.9 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX04947.1 - 0.041 13.8 0.0 1.4 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.1 EFX04947.1 - 0.059 12.7 0.0 0.36 10.1 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA PF00004.24 EFX04947.1 - 0.078 13.1 0.0 1.6 8.9 0.0 2.6 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 EFX04947.1 - 0.11 11.9 0.0 0.47 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain MobB PF03205.9 EFX04947.1 - 0.18 11.4 0.0 0.43 10.2 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AA_permease PF00324.16 EFX04948.1 - 7.7e-113 377.3 43.7 9.5e-113 377.0 30.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX04948.1 - 1.4e-36 125.9 44.4 1.9e-36 125.5 30.7 1.2 1 0 0 1 1 1 1 Amino acid permease Med26 PF08711.6 EFX04949.1 - 5.5e-13 48.2 0.0 1.1e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Exo_endo_phos PF03372.18 EFX04950.1 - 2.1e-21 76.9 1.7 3.3e-21 76.3 1.2 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EFX04950.1 - 3.4e-15 55.6 0.1 2.2e-14 53.0 0.1 2.2 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase zf-GRF PF06839.7 EFX04950.1 - 3.1e-07 30.1 2.9 7.4e-07 28.9 2.0 1.6 1 0 0 1 1 1 1 GRF zinc finger zf-RING_2 PF13639.1 EFX04951.1 - 1e-14 54.0 5.1 2.1e-14 53.0 3.5 1.6 1 0 0 1 1 1 1 Ring finger domain PA PF02225.17 EFX04951.1 - 7e-12 44.9 0.1 2.5e-11 43.1 0.0 2.0 1 1 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.1 EFX04951.1 - 1.5e-08 34.5 5.3 2.7e-08 33.6 3.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFX04951.1 - 5.6e-08 32.7 1.1 1.1e-07 31.8 0.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EFX04951.1 - 7.1e-08 31.9 2.9 1.4e-07 31.0 2.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX04951.1 - 1.5e-07 31.0 1.9 2.7e-07 30.1 1.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFX04951.1 - 2.5e-07 30.2 2.4 2.5e-07 30.2 1.7 1.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFX04951.1 - 0.00091 19.0 0.8 0.0019 17.9 0.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 EFX04951.1 - 0.089 12.6 3.8 0.2 11.5 2.6 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 EFX04951.1 - 0.17 11.9 3.3 0.31 11.1 2.3 1.5 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.24 EFX04951.1 - 0.22 11.2 1.9 0.37 10.5 1.3 1.4 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.3 EFX04951.1 - 0.28 11.1 2.7 0.95 9.4 1.9 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.1 EFX04951.1 - 0.57 9.8 2.7 1 9.0 1.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Ribonuc_L-PSP PF01042.16 EFX04952.1 - 2.2e-14 53.2 0.1 2.6e-14 53.0 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Pkinase PF00069.20 EFX04955.1 - 2.3e-50 171.1 0.0 4.2e-50 170.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04955.1 - 2.4e-24 85.7 0.1 1.2e-23 83.5 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Fungal_trans PF04082.13 EFX04956.1 - 8.1e-10 38.0 0.0 1.7e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-CCCH PF00642.19 EFX04957.1 - 3e-05 23.5 7.5 0.0011 18.6 0.8 3.2 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Collagen PF01391.13 EFX04957.1 - 0.013 15.0 2.3 0.034 13.7 1.6 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) FOLN PF09289.5 EFX04957.1 - 8.5 6.3 8.6 1.8 8.4 0.5 3.1 2 1 0 2 2 2 0 Follistatin/Osteonectin-like EGF domain ARPC4 PF05856.7 EFX04958.1 - 9.1e-75 249.7 4.4 1e-74 249.5 3.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) O-FucT PF10250.4 EFX04959.1 - 5.7e-05 22.3 0.1 0.0021 17.2 0.1 2.1 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Pkinase PF00069.20 EFX04960.1 - 3.1e-47 160.9 0.0 4.9e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX04960.1 - 7e-17 61.3 0.0 2.3e-15 56.3 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX04960.1 - 0.18 10.7 2.0 1.8 7.4 0.1 2.5 2 1 0 3 3 3 0 Kinase-like DUF1100 PF06500.6 EFX04961.1 - 7.4e-12 44.5 0.0 1e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_5 PF12695.2 EFX04961.1 - 4.6e-11 42.6 0.1 1.2e-10 41.3 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX04961.1 - 5.5e-10 39.4 8.5 5.5e-10 39.4 5.9 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 EFX04961.1 - 7e-06 25.6 0.1 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.15 EFX04961.1 - 0.00015 21.2 0.1 0.00049 19.6 0.1 1.8 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 EFX04961.1 - 0.0007 18.8 0.6 0.0054 15.9 0.4 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 EFX04961.1 - 0.073 12.6 0.2 2 7.9 0.2 2.4 2 0 0 2 2 2 0 alpha/beta hydrolase fold EcKinase PF02958.15 EFX04963.1 - 7.1e-20 71.3 0.0 4.6e-19 68.6 0.0 1.9 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.18 EFX04963.1 - 7.7e-10 38.8 0.3 1e-09 38.5 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 EFX04963.1 - 7.5e-08 31.4 0.0 1.2e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) NAD_binding_10 PF13460.1 EFX04964.1 - 1.9e-11 44.2 0.0 4.8e-11 42.9 0.0 1.7 1 1 1 2 2 2 1 NADH(P)-binding NmrA PF05368.8 EFX04964.1 - 1.5e-08 34.1 0.0 3.3e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family F420_oxidored PF03807.12 EFX04964.1 - 0.00038 20.8 0.0 0.0095 16.3 0.0 2.6 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.1 EFX04964.1 - 0.0014 18.8 0.0 0.013 15.7 0.0 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding TrkA_N PF02254.13 EFX04964.1 - 0.0099 15.8 0.1 0.035 14.0 0.0 2.0 1 1 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.16 EFX04964.1 - 0.021 14.4 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Rossmann-like PF10727.4 EFX04964.1 - 0.035 13.8 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 Rossmann-like domain Saccharop_dh PF03435.13 EFX04964.1 - 0.098 11.6 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase AhpC-TSA PF00578.16 EFX04965.1 - 3.4e-37 126.8 0.0 4.6e-37 126.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EFX04965.1 - 2.1e-14 53.2 0.0 3.1e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 EFX04965.1 - 2.6e-12 46.1 0.1 7.2e-12 44.7 0.0 1.8 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin RNA_pol_Rpc82 PF05645.8 EFX04966.1 - 0.017 14.7 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 Bac_luciferase PF00296.15 EFX04967.1 - 9e-58 195.8 1.1 1.1e-57 195.4 0.8 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase AATase PF07247.7 EFX04968.1 - 3.8e-10 38.9 0.2 2.8e-09 36.0 0.2 1.9 1 1 0 1 1 1 1 Alcohol acetyltransferase Lipase_3 PF01764.20 EFX04969.1 - 3e-14 52.8 0.0 2.5e-13 49.8 0.0 2.2 1 1 0 1 1 1 1 Lipase (class 3) ADH_N PF08240.7 EFX04969.1 - 6.9e-13 48.3 3.1 8e-13 48.1 0.5 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Mito_fiss_reg PF05308.6 EFX04969.1 - 2.6 7.3 8.0 4.8 6.4 2.2 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator AIRC PF00731.15 EFX04970.1 - 3.5e-60 201.6 1.2 3.5e-60 201.6 0.8 2.3 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.17 EFX04970.1 - 6.6e-45 152.5 0.0 3.5e-44 150.1 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.1 EFX04970.1 - 4.1e-13 49.4 0.0 9.8e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EFX04970.1 - 0.0011 18.3 0.0 0.017 14.4 0.0 2.7 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus XdhC_C PF13478.1 EFX04970.1 - 0.02 15.2 0.4 0.21 11.8 0.1 2.6 3 0 0 3 3 3 0 XdhC Rossmann domain PrpR_N PF06506.6 EFX04970.1 - 0.02 14.3 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 Propionate catabolism activator ATPgrasp_Ter PF15632.1 EFX04970.1 - 0.027 13.2 0.0 0.099 11.3 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon CoA_binding_2 PF13380.1 EFX04970.1 - 0.13 12.3 2.4 6.7 6.9 0.1 3.7 2 1 2 4 4 4 0 CoA binding domain Mei5 PF10376.4 EFX04970.1 - 0.22 11.0 0.0 0.35 10.3 0.0 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein Sugar_tr PF00083.19 EFX04971.1 - 1.7e-66 224.6 25.2 2e-66 224.4 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX04971.1 - 2.9e-19 68.9 48.0 4e-17 61.9 22.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX04971.1 - 1.8e-06 26.6 20.4 8.6e-05 21.1 2.9 3.7 4 1 0 4 4 4 2 MFS/sugar transport protein MFS_1_like PF12832.2 EFX04971.1 - 0.00019 21.1 1.2 0.21 11.3 0.1 2.9 2 0 0 2 2 2 2 MFS_1 like family DUF2892 PF11127.3 EFX04971.1 - 0.0071 16.1 2.2 0.0071 16.1 1.5 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2892) Tower PF09121.5 EFX04973.1 - 0.033 14.1 1.1 0.098 12.6 0.8 1.8 1 0 0 1 1 1 0 Tower Nop14 PF04147.7 EFX04974.1 - 0.0024 15.8 43.3 0.0035 15.3 30.0 1.2 1 0 0 1 1 1 1 Nop14-like family OTT_1508_deam PF14441.1 EFX04974.1 - 0.0073 16.1 0.0 0.037 13.8 0.0 2.2 1 0 0 1 1 1 1 OTT_1508-like deaminase SAPS PF04499.10 EFX04974.1 - 1 7.9 11.8 1.6 7.3 8.2 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ycf1 PF05758.7 EFX04974.1 - 8.4 3.9 9.8 10 3.6 6.8 1.2 1 0 0 1 1 1 0 Ycf1 Transket_pyr PF02779.19 EFX04975.1 - 8.4e-47 158.9 0.0 1.1e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EFX04975.1 - 5.5e-37 126.4 0.1 1.9e-36 124.7 0.0 1.9 2 0 0 2 2 2 1 Transketolase, C-terminal domain AA_permease PF00324.16 EFX04976.1 - 1.9e-104 349.7 46.5 2.3e-104 349.4 32.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX04976.1 - 3.8e-28 98.1 48.1 4.8e-28 97.8 33.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1612 PF07756.7 EFX04976.1 - 0.53 10.3 2.1 16 5.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) RRM_1 PF00076.17 EFX04977.1 - 1e-08 34.6 0.0 1.9e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX04977.1 - 1.1e-08 34.8 0.0 1.8e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX04977.1 - 3.7e-05 23.6 0.0 8.8e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EFX04977.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EFX04977.1 - 0.021 14.6 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif Tyrosinase PF00264.15 EFX04978.1 - 2.4e-46 158.6 0.0 3.2e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase CFEM PF05730.6 EFX04979.1 - 2.6e-06 27.1 17.1 2.6e-06 27.1 11.8 2.5 2 1 1 3 3 3 1 CFEM domain Borrelia_rep PF03183.8 EFX04979.1 - 1.6 8.6 5.8 6.4 6.7 4.0 2.1 1 0 0 1 1 1 0 Borrelia repeat protein ADH_zinc_N PF00107.21 EFX04980.1 - 8.5e-25 86.7 0.3 1.2e-24 86.2 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX04980.1 - 1.8e-20 72.7 1.2 3.4e-20 71.8 0.8 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF3279 PF11682.3 EFX04980.1 - 0.26 10.8 1.2 0.42 10.1 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) DUF1993 PF09351.5 EFX04981.1 - 2.1e-46 157.8 0.1 2.4e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) Methyltransf_23 PF13489.1 EFX04982.1 - 2.9e-20 72.6 0.0 4.5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX04982.1 - 2.1e-09 37.1 0.0 9.8e-09 34.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX04982.1 - 8.5e-09 35.7 0.0 6.2e-08 33.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX04982.1 - 1.4e-08 35.1 0.0 3.7e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX04982.1 - 1.7e-07 31.7 0.0 1.3e-06 28.9 0.0 2.4 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EFX04982.1 - 0.0042 16.5 0.0 0.007 15.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX04982.1 - 0.011 15.7 0.0 0.031 14.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EFX04982.1 - 0.012 14.9 0.0 0.027 13.8 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain FtsJ PF01728.14 EFX04982.1 - 0.016 15.2 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 EFX04982.1 - 0.024 13.6 0.0 0.14 11.1 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_25 PF13649.1 EFX04982.1 - 0.026 14.8 0.0 0.063 13.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EFX04982.1 - 0.03 13.4 0.0 0.045 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PX PF00787.19 EFX04983.1 - 1.8e-24 85.6 0.0 2.7e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 PX domain Fungal_trans_2 PF11951.3 EFX04986.1 - 2.8e-49 167.7 8.3 3.4e-49 167.4 5.8 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04986.1 - 4.7e-06 26.4 7.6 1.1e-05 25.2 5.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SnoaL_4 PF13577.1 EFX04987.1 - 1e-16 61.0 0.3 3.5e-16 59.2 0.0 2.2 3 0 0 3 3 3 1 SnoaL-like domain Fungal_trans PF04082.13 EFX04987.1 - 2.6e-05 23.2 0.0 4.9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidase_2 PF01510.20 EFX04988.1 - 1.7e-08 34.5 0.1 4.3e-08 33.2 0.0 1.6 2 0 0 2 2 2 1 N-acetylmuramoyl-L-alanine amidase PG_binding_1 PF01471.13 EFX04988.1 - 3e-06 27.1 0.0 5.8e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.5 EFX04988.1 - 0.057 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Predicted Peptidoglycan domain Autophagy_N PF03986.8 EFX04991.1 - 3.5e-43 146.8 0.5 8.1e-43 145.6 0.0 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 EFX04991.1 - 5.3e-22 77.7 0.1 1.2e-21 76.6 0.1 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 EFX04991.1 - 5.2e-06 25.4 0.4 1.2e-05 24.2 0.3 1.7 1 1 0 1 1 1 1 Autophagocytosis associated protein C-terminal PBP1_TM PF14812.1 EFX04991.1 - 1.2 9.4 11.8 0.11 12.8 4.2 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.5 EFX04991.1 - 2.4 8.4 13.1 0.1 12.8 4.8 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Nucleoplasmin PF03066.10 EFX04991.1 - 2.6 7.5 7.8 5.1 6.5 5.4 1.5 1 0 0 1 1 1 0 Nucleoplasmin FA_desaturase PF00487.19 EFX04992.1 - 9e-26 90.8 29.6 1.4e-25 90.2 20.5 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 EFX04992.1 - 7.3e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Fungal_trans PF04082.13 EFX04993.1 - 1.3e-18 66.8 1.7 3e-18 65.6 0.2 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX04993.1 - 2.1e-05 24.3 13.4 4.2e-05 23.3 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.20 EFX04994.1 - 2.1e-19 70.0 0.1 3.6e-19 69.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX04994.1 - 6.7e-11 42.4 0.0 2.6e-10 40.4 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX04994.1 - 2.1e-05 24.2 0.1 3.5e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.21 EFX04995.1 - 3.2e-28 97.8 0.1 7.9e-28 96.6 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase MFS_1 PF07690.11 EFX04995.1 - 5.5e-28 97.7 32.3 9.1e-28 96.9 22.4 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily ADH_N PF08240.7 EFX04995.1 - 2.5e-25 88.3 1.7 4.8e-25 87.4 1.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.1 EFX04995.1 - 7.2e-05 22.3 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated NAD_binding_7 PF13241.1 EFX04995.1 - 0.0005 20.2 2.6 0.017 15.3 0.4 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding ADH_zinc_N_2 PF13602.1 EFX04995.1 - 0.0026 18.6 0.0 0.0063 17.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.14 EFX04995.1 - 0.0038 16.3 0.2 0.0038 16.3 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 EFX04995.1 - 0.0091 16.0 0.3 0.36 10.8 0.2 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 EFX04995.1 - 0.013 15.0 0.4 0.087 12.3 0.1 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.9 EFX04995.1 - 0.031 14.1 0.7 0.09 12.6 0.5 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX04995.1 - 0.042 12.6 2.4 0.074 11.8 1.7 1.4 1 0 0 1 1 1 0 FAD binding domain DUF2649 PF10854.3 EFX04995.1 - 3.7 7.7 4.9 1.2 9.3 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2649) FAD_binding_3 PF01494.14 EFX04996.1 - 1.7e-20 73.4 1.3 4.7e-13 48.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.9 EFX04996.1 - 4.5e-07 28.8 4.8 0.0023 16.6 0.1 2.1 1 1 1 2 2 2 2 Tryptophan halogenase DAO PF01266.19 EFX04996.1 - 7.8e-06 25.0 13.0 0.0079 15.1 3.6 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX04996.1 - 2.4e-05 24.2 4.8 0.00016 21.6 1.1 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX04996.1 - 0.00031 20.5 0.4 0.0025 17.6 0.1 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EFX04996.1 - 0.00083 19.4 0.1 0.0017 18.4 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX04996.1 - 0.0019 17.1 6.3 0.0019 17.1 4.3 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.2 EFX04996.1 - 0.002 17.2 1.1 0.0033 16.5 0.8 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EFX04996.1 - 0.004 15.6 4.3 0.0097 14.4 1.9 1.9 2 0 0 2 2 2 1 HI0933-like protein 3HCDH_N PF02737.13 EFX04996.1 - 0.032 13.8 1.7 0.062 12.9 1.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.9 EFX04996.1 - 0.036 13.9 2.2 0.066 13.0 1.5 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 EFX04996.1 - 0.037 13.1 2.7 2.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.17 EFX04996.1 - 0.04 12.7 5.2 0.072 11.9 3.6 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 EFX04996.1 - 0.046 13.3 0.6 0.094 12.2 0.4 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 EFX04996.1 - 0.061 12.2 3.8 0.27 10.0 2.6 2.0 1 1 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.22 EFX04996.1 - 0.33 11.4 5.6 0.27 11.6 2.4 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX04996.1 - 0.64 9.0 3.6 0.18 10.8 0.4 1.5 2 0 0 2 2 2 0 Thi4 family Bac_rhamnosid PF05592.6 EFX04997.1 - 1.7e-26 92.5 0.2 1.5e-19 69.6 0.4 2.5 1 1 1 2 2 2 2 Bacterial alpha-L-rhamnosidase DUF608 PF04685.8 EFX04997.1 - 0.005 15.5 0.5 0.0089 14.7 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF608 Spherulin4 PF12138.3 EFX04998.1 - 1e-48 166.0 0.0 1.2e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 DIOX_N PF14226.1 EFX04999.1 - 2.4e-27 95.7 0.0 3.4e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX04999.1 - 9.8e-25 86.7 0.0 2.6e-24 85.4 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily adh_short PF00106.20 EFX05000.1 - 1.1e-28 100.2 1.6 1.9e-28 99.5 1.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX05000.1 - 2.1e-16 60.4 0.0 2.8e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX05000.1 - 1.9e-10 40.7 1.9 4.3e-10 39.5 1.3 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFX05000.1 - 0.0056 16.7 1.7 0.011 15.7 0.6 1.9 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 EFX05000.1 - 0.012 15.0 0.5 0.05 13.0 0.4 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_M20 PF01546.23 EFX05001.1 - 3.6e-25 88.5 0.0 7.1e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX05001.1 - 1.4e-17 63.4 0.1 2.6e-17 62.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFX05001.1 - 0.0046 16.7 0.0 0.013 15.2 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 TFIIA_gamma_C PF02751.9 EFX05001.1 - 0.17 11.6 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit AA_permease PF00324.16 EFX05002.1 - 7.2e-85 285.1 34.4 8.1e-85 284.9 23.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX05002.1 - 3e-32 111.7 35.9 3.6e-32 111.4 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease XdhC_CoxI PF02625.11 EFX05002.1 - 0.16 11.5 0.8 2.8 7.6 0.0 2.8 3 0 0 3 3 3 0 XdhC and CoxI family Pec_lyase_C PF00544.14 EFX05003.1 - 4.7e-43 146.9 10.8 6.6e-43 146.5 7.5 1.2 1 0 0 1 1 1 1 Pectate lyase CAP_N PF01213.14 EFX05004.1 - 0.05 12.8 0.1 0.059 12.6 0.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF829 PF05705.9 EFX05005.1 - 5.5e-55 186.6 0.0 6.3e-55 186.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Na_H_Exchanger PF00999.16 EFX05006.1 - 1.5e-22 79.6 46.2 3.3e-21 75.2 22.7 3.6 2 1 0 2 2 2 2 Sodium/hydrogen exchanger family Isochorismatase PF00857.15 EFX05007.1 - 2e-46 158.1 0.0 2.3e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family zf-C3HC4_3 PF13920.1 EFX05009.1 - 3.2e-08 33.1 5.8 4.9e-08 32.5 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EFX05009.1 - 1.1e-07 31.7 9.2 1.9e-07 30.9 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.19 EFX05009.1 - 2.1e-07 30.4 1.7 4e-07 29.5 1.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_5 PF14634.1 EFX05009.1 - 4.8e-07 29.4 7.8 7.8e-07 28.7 5.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EFX05009.1 - 5.9e-07 29.0 7.6 9.9e-07 28.3 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX05009.1 - 3.2e-06 26.8 7.4 5.1e-06 26.2 5.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 EFX05009.1 - 0.00077 19.2 6.6 0.0018 18.0 4.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EFX05009.1 - 0.0014 18.3 2.9 0.003 17.2 2.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.3 EFX05009.1 - 0.051 13.0 1.8 0.1 12.1 1.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Cript PF10235.4 EFX05009.1 - 0.067 13.5 2.5 0.19 12.0 1.7 1.8 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Prok-RING_4 PF14447.1 EFX05009.1 - 0.14 11.7 4.8 0.26 10.8 3.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.2 EFX05009.1 - 1.2 9.3 4.8 2.9 8.0 3.3 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger AA_permease_2 PF13520.1 EFX05011.1 - 1.1e-60 205.4 48.1 1.4e-60 205.0 33.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX05011.1 - 1.9e-23 82.5 39.3 2.5e-23 82.1 27.3 1.0 1 0 0 1 1 1 1 Amino acid permease SpoVAB PF13782.1 EFX05011.1 - 0.12 12.3 0.1 0.12 12.3 0.1 3.6 5 0 0 5 5 5 0 Stage V sporulation protein AB HeLo PF14479.1 EFX05012.1 - 2.1e-40 138.7 4.6 2.6e-40 138.4 3.2 1.1 1 0 0 1 1 1 1 Prion-inhibition and propagation HET-s_218-289 PF11558.3 EFX05012.1 - 1.2e-07 31.5 0.3 3.8e-07 29.9 0.2 1.9 1 0 0 1 1 1 1 Het-s 218-289 Ead_Ea22 PF13935.1 EFX05012.1 - 0.23 11.7 6.9 0.1 12.8 1.1 2.1 1 1 1 2 2 2 0 Ead/Ea22-like protein YgaB PF14182.1 EFX05012.1 - 0.36 11.0 3.6 0.81 9.9 0.7 2.2 2 0 0 2 2 2 0 YgaB-like protein CENP-Q PF13094.1 EFX05012.1 - 1.5 8.8 6.2 0.42 10.6 1.3 2.0 1 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit dCMP_cyt_deam_1 PF00383.17 EFX05013.1 - 1.4e-20 72.8 0.0 4.6e-20 71.1 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 EFX05013.1 - 4.2e-05 23.4 2.9 0.072 12.9 0.1 2.5 2 0 0 2 2 2 2 Bd3614-like deaminase Chordopox_A20R PF05941.8 EFX05013.1 - 0.16 10.7 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A20R protein PMT PF02366.13 EFX05014.1 - 4.1e-74 249.0 15.4 4.1e-74 249.0 10.7 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EFX05014.1 - 4.6e-50 169.8 0.0 7.1e-50 169.1 0.0 1.3 1 0 0 1 1 1 1 MIR domain C-term_anchor PF13461.1 EFX05014.1 - 0.06 13.8 0.3 8.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Cell-wall surface anchor repeat Peptidase_M19 PF01244.16 EFX05015.1 - 2e-109 365.4 0.0 2.5e-109 365.0 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) UCH PF00443.24 EFX05016.1 - 2.6e-52 177.6 0.0 3.3e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EFX05016.1 - 1.5e-23 83.7 0.0 3.5e-23 82.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 EFX05016.1 - 0.00012 21.3 0.2 0.00012 21.3 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin family SR-25 PF10500.4 EFX05016.1 - 0.0052 16.2 11.1 0.0052 16.2 7.7 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Med9 PF07544.8 EFX05016.1 - 0.041 13.6 1.0 0.12 12.1 0.7 1.8 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF2201_N PF13203.1 EFX05016.1 - 0.091 11.9 8.6 1.8 7.6 0.1 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain Cnd1_N PF12922.2 EFX05016.1 - 1.5 8.4 6.1 1.3 8.6 1.7 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Vfa1 PF08432.5 EFX05016.1 - 5.7 6.9 11.8 0.25 11.3 4.1 1.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Striatin PF08232.7 EFX05016.1 - 5.9 7.2 10.5 1.2 9.4 4.4 1.9 2 0 0 2 2 2 0 Striatin family DUF917 PF06032.7 EFX05017.1 - 3.9e-105 351.2 0.4 8.1e-105 350.2 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 EFX05017.1 - 4.1e-47 160.6 9.0 5.8e-46 156.8 4.1 3.0 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFX05017.1 - 2e-29 102.3 0.4 7.9e-27 93.8 0.0 2.8 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.15 EFX05017.1 - 3e-06 26.7 6.6 0.00048 19.5 0.1 3.0 3 0 0 3 3 3 2 BadF/BadG/BcrA/BcrD ATPase family MutL PF13941.1 EFX05017.1 - 0.0028 16.0 0.9 0.18 10.0 0.0 2.3 2 0 0 2 2 2 2 MutL protein StbA PF06406.6 EFX05017.1 - 0.0062 15.5 0.7 0.69 8.7 0.1 2.3 2 0 0 2 2 2 2 StbA protein Oxidored_FMN PF00724.15 EFX05018.1 - 1.1e-54 185.6 0.0 5.8e-43 147.1 0.0 2.0 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family RST PF12174.3 EFX05018.1 - 0.1 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain adh_short PF00106.20 EFX05019.1 - 4e-24 85.4 4.0 5.4e-24 84.9 2.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX05019.1 - 1.2e-22 80.8 0.1 1.5e-22 80.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX05019.1 - 7.1e-14 51.8 1.0 1.2e-13 51.1 0.7 1.3 1 0 0 1 1 1 1 KR domain Glyco_transf_28 PF03033.15 EFX05019.1 - 0.014 15.1 0.2 0.071 12.8 0.2 2.1 1 1 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain WzyE PF06899.6 EFX05019.1 - 0.13 10.8 0.0 0.27 9.8 0.0 1.5 2 0 0 2 2 2 0 WzyE protein COX6A PF02046.10 EFX05020.1 - 9.5e-45 151.2 0.4 1e-44 151.1 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa RRM_6 PF14259.1 EFX05021.1 - 3.8e-09 36.3 0.2 0.029 14.3 0.0 4.7 5 0 0 5 5 5 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 EFX05021.1 - 3.3e-08 33.0 17.1 2.2e-05 24.0 4.0 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.17 EFX05021.1 - 0.0071 15.9 0.0 0.23 11.0 0.0 3.1 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4 PF00097.20 EFX05021.1 - 0.0096 15.5 13.1 0.022 14.4 8.7 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFX05021.1 - 0.044 13.6 13.5 0.15 11.9 9.4 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Bet_v_1 PF00407.14 EFX05021.1 - 0.14 11.7 0.1 0.35 10.4 0.0 1.7 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family zf-C3HC4_3 PF13920.1 EFX05021.1 - 0.23 11.1 12.0 0.57 9.9 8.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX05021.1 - 0.62 9.9 17.9 0.1 12.4 8.8 2.4 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.1 EFX05021.1 - 1.4 9.0 19.2 0.2 11.7 10.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) NYN PF01936.13 EFX05022.1 - 5.6e-06 26.7 0.0 0.00017 21.9 0.0 2.3 1 1 0 1 1 1 1 NYN domain Peptidase_S66 PF02016.10 EFX05023.1 - 1.6e-42 145.4 0.0 2.4e-33 115.3 0.0 2.1 1 1 1 2 2 2 2 LD-carboxypeptidase Metallophos_C PF14008.1 EFX05024.1 - 6e-18 64.6 0.3 1.8e-17 63.1 0.2 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.23 EFX05024.1 - 9.2e-18 64.3 1.0 1.9e-17 63.3 0.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD PF09423.5 EFX05024.1 - 1.3e-06 27.2 0.0 3.2e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 PhoD-like phosphatase Metallophos_2 PF12850.2 EFX05024.1 - 0.04 13.7 0.0 0.099 12.4 0.0 1.6 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Dioxygenase_C PF00775.16 EFX05025.1 - 9.6e-43 145.5 0.0 1.2e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 EFX05025.1 - 4.5e-12 45.7 0.0 7.5e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.1 EFX05025.1 - 0.11 12.5 0.0 0.46 10.5 0.0 1.9 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Pkinase PF00069.20 EFX05026.1 - 0.0012 18.0 0.0 0.0016 17.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFX05026.1 - 0.027 14.2 0.1 0.054 13.2 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 EFX05026.1 - 0.039 13.0 0.0 0.051 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Kinase-like PF14531.1 EFX05026.1 - 0.13 11.1 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Methyltransf_PK PF05891.7 EFX05027.1 - 9.1e-66 221.2 0.0 2.6e-32 111.9 0.0 2.0 2 0 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.13 EFX05027.1 - 0.017 14.2 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase MFS_1 PF07690.11 EFX05028.1 - 8.9e-33 113.4 18.1 1.5e-32 112.7 12.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily SdpI PF13630.1 EFX05028.1 - 6.3 6.5 12.1 1.5 8.5 0.2 4.1 4 0 0 4 4 4 0 SdpI/YhfL protein family Sugar_tr PF00083.19 EFX05030.1 - 1.4e-80 271.0 21.1 1.6e-80 270.9 14.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05030.1 - 2.5e-33 115.2 47.1 3.5e-28 98.3 16.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX05030.1 - 9.3e-05 20.8 1.1 9.3e-05 20.8 0.7 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) SET PF00856.23 EFX05031.1 - 3.8e-13 50.0 0.0 2.5e-12 47.3 0.0 2.0 1 1 0 1 1 1 1 SET domain F-box-like PF12937.2 EFX05032.1 - 0.08 12.6 1.7 0.42 10.3 1.2 2.2 1 1 0 1 1 1 0 F-box-like Sugar_tr PF00083.19 EFX05033.1 - 4.8e-82 275.9 27.8 5.5e-82 275.7 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05033.1 - 5.7e-30 104.2 33.6 2.8e-25 88.7 6.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX05033.1 - 8.2e-07 27.5 1.7 8.2e-07 27.5 1.2 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MscL PF01741.13 EFX05033.1 - 0.27 11.3 6.5 0.23 11.6 0.3 2.7 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Brr6_like_C_C PF10104.4 EFX05034.1 - 7.2e-37 125.9 0.4 9.5e-37 125.5 0.3 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain MCM2_N PF12619.3 EFX05034.1 - 0.005 16.8 4.0 0.009 16.0 2.8 1.3 1 0 0 1 1 1 1 Mini-chromosome maintenance protein 2 Fumble PF03630.9 EFX05035.1 - 1.1e-132 442.1 0.1 2.1e-131 437.8 0.1 2.1 1 1 0 1 1 1 1 Fumble ABC2_membrane_3 PF12698.2 EFX05036.1 - 0.098 11.6 0.7 0.14 11.1 0.2 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein TauD PF02668.11 EFX05037.1 - 4.1e-32 111.8 0.1 5.3e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF2989 PF11207.3 EFX05037.1 - 0.065 12.6 0.0 0.099 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) ADH_zinc_N PF00107.21 EFX05038.1 - 2.9e-12 46.2 0.0 6.7e-12 45.0 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_3 PF13738.1 EFX05038.1 - 0.26 11.3 1.0 9.8 6.1 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.11 EFX05040.1 - 8.8e-16 57.5 52.6 9e-14 50.9 36.4 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Pox_A14 PF05767.7 EFX05040.1 - 0.16 11.9 3.3 0.16 11.9 0.2 2.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 TauD PF02668.11 EFX05042.1 - 1.9e-26 93.2 0.1 7e-26 91.4 0.0 2.0 2 1 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.11 EFX05043.1 - 2.3e-23 82.5 33.7 4.4e-16 58.5 9.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05043.1 - 1.5e-18 66.5 29.5 8.2e-17 60.9 20.5 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter zf-DHHC PF01529.15 EFX05043.1 - 5 6.4 9.7 0.12 11.7 1.4 2.2 2 1 0 2 2 2 0 DHHC palmitoyltransferase DUF2052 PF09747.4 EFX05044.1 - 7.5e-17 61.8 3.6 1.4e-16 60.9 2.5 1.5 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Chitin_bind_3 PF03067.10 EFX05046.1 - 1.7e-13 51.2 0.6 2.9e-13 50.5 0.4 1.4 1 0 0 1 1 1 1 Chitin binding domain Vac7 PF12751.2 EFX05047.1 - 0.053 12.3 4.6 0.63 8.8 0.0 2.6 3 0 0 3 3 3 0 Vacuolar segregation subunit 7 zf-C2HC_2 PF13913.1 EFX05048.1 - 0.0076 15.8 3.6 0.66 9.7 0.4 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type CpXC PF14353.1 EFX05048.1 - 0.12 12.3 0.4 0.93 9.4 0.0 2.5 1 1 1 2 2 2 0 CpXC protein zf-C2H2_4 PF13894.1 EFX05048.1 - 0.37 11.2 3.7 0.69 10.3 1.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX05048.1 - 1.4 9.3 5.3 0.32 11.4 0.5 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type VWA_2 PF13519.1 EFX05049.1 - 0.028 14.5 0.0 0.083 12.9 0.0 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain VWA PF00092.23 EFX05049.1 - 0.096 12.4 0.0 5.6 6.6 0.0 2.7 3 1 0 3 3 3 0 von Willebrand factor type A domain MFS_1 PF07690.11 EFX05050.1 - 1.7e-24 86.2 66.8 2.7e-20 72.4 28.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX05050.1 - 0.002 16.6 26.8 0.036 12.4 3.1 3.8 3 2 1 4 4 4 3 MFS/sugar transport protein Chlorosome_CsmC PF11098.3 EFX05050.1 - 0.16 11.6 3.7 0.24 11.0 0.1 2.6 3 0 0 3 3 3 0 Chlorosome envelope protein C Sugar_tr PF00083.19 EFX05050.1 - 1 7.8 23.5 0.0061 15.1 7.7 2.6 2 2 0 2 2 2 0 Sugar (and other) transporter Abhydrolase_5 PF12695.2 EFX05053.1 - 1.2e-11 44.5 0.1 2.3e-11 43.6 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX05053.1 - 5.2e-11 42.8 0.4 8.9e-11 42.1 0.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX05053.1 - 0.00012 21.3 0.0 0.00021 20.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 EFX05053.1 - 0.00016 21.2 0.1 0.0006 19.4 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.7 EFX05053.1 - 0.0013 17.3 0.1 0.012 14.1 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.8 EFX05053.1 - 0.0016 18.0 0.2 0.011 15.3 0.0 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFX05053.1 - 0.13 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase PGAP1 PF07819.8 EFX05053.1 - 0.16 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein UPF0227 PF05728.7 EFX05053.1 - 0.16 11.6 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Hist_deacetyl PF00850.14 EFX05054.1 - 2.2e-61 207.8 0.0 2.9e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Retrotrans_gag PF03732.12 EFX05055.1 - 6.4e-08 32.5 0.1 1.1e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein DUF2404 PF10296.4 EFX05056.1 - 1.2e-24 86.2 0.0 2.8e-24 85.0 0.0 1.6 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) PH PF00169.24 EFX05056.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 PH domain MFS_1 PF07690.11 EFX05057.1 - 1.1e-21 76.9 73.5 3.9e-19 68.5 35.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LSM PF01423.17 EFX05059.1 - 2.1e-16 59.1 0.0 2.6e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain Fungal_trans PF04082.13 EFX05060.1 - 5.8e-11 41.7 0.6 7.6e-11 41.3 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-FCS PF06467.9 EFX05060.1 - 0.16 11.6 1.8 9.3 5.9 0.2 2.6 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif ketoacyl-synt PF00109.21 EFX05061.1 - 7.8e-70 235.2 0.2 1.7e-69 234.1 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 EFX05061.1 - 1.9e-57 193.8 0.2 5.9e-57 192.2 0.1 2.0 1 0 0 1 1 1 1 KR domain PS-DH PF14765.1 EFX05061.1 - 1.7e-53 181.6 4.1 3.9e-53 180.5 2.8 1.7 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.16 EFX05061.1 - 2.3e-44 152.0 0.3 5.1e-44 150.9 0.2 1.5 1 0 0 1 1 1 1 Acyl transferase domain adh_short PF00106.20 EFX05061.1 - 2.1e-43 148.1 0.2 2.1e-43 148.1 0.2 3.3 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EFX05061.1 - 5.6e-36 122.9 0.1 1.5e-35 121.5 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.1 EFX05061.1 - 1.2e-14 55.3 0.1 1.8e-13 51.4 0.0 3.2 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFX05061.1 - 8.5e-14 51.2 0.0 3.9e-13 49.0 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.1 EFX05061.1 - 9.9e-07 28.6 0.0 3.5e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05061.1 - 1.1e-05 25.8 0.0 5.3e-05 23.6 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.7 EFX05061.1 - 3.1e-05 23.6 0.0 7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_18 PF12847.2 EFX05061.1 - 0.0016 19.0 0.1 0.12 12.9 0.0 3.8 3 0 0 3 3 3 1 Methyltransferase domain PP-binding PF00550.20 EFX05061.1 - 0.0017 18.6 0.3 0.0074 16.5 0.2 2.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.1 EFX05061.1 - 0.0018 17.8 0.0 0.0054 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Saccharop_dh PF03435.13 EFX05061.1 - 0.0051 15.8 0.5 0.042 12.8 0.0 2.5 3 0 0 3 3 3 1 Saccharopine dehydrogenase Methyltransf_11 PF08241.7 EFX05061.1 - 0.0052 17.2 0.0 0.032 14.7 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain DnaJ PF00226.26 EFX05062.1 - 3.8e-20 71.3 1.6 1.7e-19 69.3 1.1 2.2 1 0 0 1 1 1 1 DnaJ domain Ald_Xan_dh_C2 PF02738.13 EFX05062.1 - 0.48 8.6 5.8 4 5.6 2.8 2.1 2 0 0 2 2 2 0 Molybdopterin-binding domain of aldehyde dehydrogenase Ribosomal_S4 PF00163.14 EFX05063.1 - 1.1e-28 99.3 0.7 2.4e-28 98.3 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 EFX05063.1 - 3.6e-14 51.9 1.7 3.6e-14 51.9 1.2 2.5 3 0 0 3 3 3 1 S4 domain PAP2_3 PF14378.1 EFX05065.1 - 7.1e-21 74.6 7.6 1.1e-16 60.9 1.4 2.2 2 0 0 2 2 2 2 PAP2 superfamily PAP2_C PF14360.1 EFX05065.1 - 0.064 13.5 0.0 0.064 13.5 0.0 3.0 3 0 0 3 3 3 0 PAP2 superfamily C-terminal PAP2 PF01569.16 EFX05065.1 - 0.084 12.5 4.0 0.15 11.7 2.5 1.6 1 1 0 1 1 1 0 PAP2 superfamily MFS_1 PF07690.11 EFX05067.1 - 7.5e-35 120.2 13.2 7.5e-35 120.2 9.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Peptidase_S8 PF00082.17 EFX05069.1 - 3.3e-48 164.2 0.0 9.2e-48 162.8 0.0 1.9 1 1 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 EFX05069.1 - 9.2e-08 32.4 0.0 3e-07 30.8 0.0 2.0 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) F-box-like PF12937.2 EFX05071.1 - 0.0088 15.7 0.8 0.02 14.5 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX05071.1 - 0.033 13.8 0.6 0.06 13.0 0.4 1.4 1 0 0 1 1 1 0 F-box domain Nop25 PF09805.4 EFX05071.1 - 1.8 8.5 5.4 2.5 8.1 3.7 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) PAT1 PF09770.4 EFX05072.1 - 0.082 11.1 21.7 0.088 11.0 15.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1395 PF07160.7 EFX05072.1 - 0.29 10.6 7.1 2 7.8 5.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1395) TFIIA PF03153.8 EFX05072.1 - 0.58 9.9 9.6 0.61 9.9 6.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Metal_resist PF13801.1 EFX05072.1 - 4.5 7.2 8.7 1.8 8.5 3.9 2.0 2 0 0 2 2 2 0 Heavy-metal resistance Ribosomal_L21e PF01157.13 EFX05073.1 - 3.7e-40 135.7 4.5 5.4e-40 135.1 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e Methyltransf_31 PF13847.1 EFX05074.1 - 7.3e-15 54.8 0.0 9.7e-15 54.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX05074.1 - 9.9e-15 54.6 0.0 1.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05074.1 - 7e-14 52.3 0.0 1.2e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05074.1 - 7.4e-12 45.6 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05074.1 - 6e-11 42.4 0.2 1e-10 41.6 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05074.1 - 2.8e-10 40.4 0.0 4.9e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05074.1 - 3.9e-09 36.8 0.0 6.6e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX05074.1 - 0.00016 20.8 0.0 0.00021 20.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 EFX05074.1 - 0.0005 18.8 0.0 0.00072 18.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) FtsJ PF01728.14 EFX05074.1 - 0.0015 18.5 0.0 0.0025 17.8 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.8 EFX05074.1 - 0.0057 15.8 0.0 0.0075 15.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 EFX05074.1 - 0.013 14.5 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 EFX05074.1 - 0.016 14.5 0.0 0.036 13.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain NodS PF05401.6 EFX05074.1 - 0.031 13.6 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.1 EFX05074.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EFX05074.1 - 0.18 11.3 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Bot1p PF12298.3 EFX05076.1 - 2.6e-44 151.2 1.9 3.7e-44 150.6 0.2 1.9 1 1 1 2 2 2 1 Eukaryotic mitochondrial regulator protein PHO4 PF01384.15 EFX05077.1 - 5.1e-98 327.7 21.9 6.5e-98 327.3 15.2 1.1 1 0 0 1 1 1 1 Phosphate transporter family Apc5 PF12862.2 EFX05077.1 - 3.4e-12 46.0 0.1 9.2e-12 44.6 0.0 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 TPR_19 PF14559.1 EFX05077.1 - 0.001 19.3 1.4 0.63 10.4 0.1 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat PPR_3 PF13812.1 EFX05077.1 - 0.19 12.0 5.1 8.6 6.9 0.0 4.6 5 0 0 5 5 5 0 Pentatricopeptide repeat domain AA_permease_2 PF13520.1 EFX05078.1 - 2.5e-39 135.0 57.5 3.2e-39 134.6 39.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX05078.1 - 5.4e-24 84.3 53.6 3.5e-23 81.7 37.1 1.9 1 1 0 1 1 1 1 Amino acid permease Mcp5_PH PF12814.2 EFX05079.1 - 9.6e-42 141.7 0.0 2.8e-41 140.2 0.0 1.9 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology ERM PF00769.14 EFX05079.1 - 0.18 11.3 36.4 0.2 11.1 1.5 3.5 3 0 0 3 3 3 0 Ezrin/radixin/moesin family Lactamase_B PF00753.22 EFX05080.1 - 2.6e-05 23.9 4.8 0.00022 20.9 3.3 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFX05080.1 - 7.1e-05 22.4 0.2 0.00012 21.6 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain FBPase PF00316.15 EFX05082.1 - 6.3e-53 179.7 1.0 2.2e-51 174.6 0.0 2.5 3 0 0 3 3 3 2 Fructose-1-6-bisphosphatase Epimerase PF01370.16 EFX05083.1 - 1.5e-15 57.2 0.2 6.5e-15 55.2 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX05083.1 - 4.2e-13 49.6 0.4 2.1e-12 47.4 0.3 1.9 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX05083.1 - 8.3e-12 44.3 0.0 1.2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EFX05083.1 - 3.9e-06 25.9 0.0 6e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EFX05083.1 - 0.00016 21.6 0.1 0.00028 20.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 EFX05083.1 - 0.0016 17.4 0.2 0.033 13.1 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EFX05083.1 - 0.002 17.4 0.0 0.0039 16.4 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family MFS_1 PF07690.11 EFX05084.1 - 4.9e-30 104.4 51.8 6.5e-30 104.0 35.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_16 PF00722.16 EFX05085.1 - 8e-11 41.5 0.0 1.4e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 ADH_N PF08240.7 EFX05087.1 - 1.6e-18 66.4 4.1 1.6e-18 66.4 2.8 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX05087.1 - 8.5e-14 51.2 0.0 1.6e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EFX05087.1 - 1.4e-05 24.2 0.0 2.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFX05087.1 - 0.0045 17.1 0.0 0.0076 16.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.10 EFX05087.1 - 0.0049 16.7 0.1 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.16 EFX05087.1 - 0.0091 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.1 EFX05087.1 - 0.012 16.5 0.0 0.019 15.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.13 EFX05087.1 - 0.036 13.7 0.1 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 EFX05088.1 - 1.2e-19 70.6 0.0 2.9e-19 69.3 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX05088.1 - 4.5e-10 38.9 0.3 3.6e-05 22.8 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX05088.1 - 4.4e-05 23.4 0.2 9.5e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX05088.1 - 7.5e-05 22.6 0.9 0.0002 21.3 0.4 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX05088.1 - 0.00024 20.1 0.7 0.0004 19.3 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 EFX05088.1 - 0.00044 19.2 0.5 0.002 17.0 0.4 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EFX05088.1 - 0.0011 17.9 0.2 0.63 8.8 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein HI0933_like PF03486.9 EFX05088.1 - 0.0016 16.9 0.4 0.0027 16.2 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein Trp_halogenase PF04820.9 EFX05088.1 - 0.0034 16.0 0.2 0.049 12.2 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.1 EFX05088.1 - 0.0039 16.9 0.2 1.5 8.5 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFX05088.1 - 0.0077 16.6 0.6 0.016 15.6 0.4 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 EFX05088.1 - 0.013 15.0 0.3 0.031 13.8 0.2 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.2 EFX05088.1 - 0.025 13.6 0.6 0.042 12.9 0.4 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.18 EFX05088.1 - 0.025 14.3 0.3 0.05 13.3 0.2 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.1 EFX05088.1 - 0.14 12.1 0.1 0.7 9.9 0.0 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.10 EFX05088.1 - 0.15 11.9 0.1 0.37 10.6 0.0 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 EFX05088.1 - 0.21 11.2 0.5 0.42 10.2 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AA_permease_2 PF13520.1 EFX05089.1 - 8.1e-92 307.9 37.2 9.8e-92 307.6 25.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX05089.1 - 1.8e-20 72.7 33.7 2.3e-20 72.3 23.3 1.2 1 0 0 1 1 1 1 Amino acid permease IMS PF00817.15 EFX05090.1 - 1.2e-35 122.5 0.0 1.9e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EFX05090.1 - 0.00013 21.8 0.1 0.006 16.5 0.0 2.5 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain zf-C2H2 PF00096.21 EFX05090.1 - 0.005 17.0 7.1 0.75 10.2 0.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX05090.1 - 0.0082 16.4 7.8 0.95 9.9 0.8 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger IMS_HHH PF11798.3 EFX05090.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif OPT PF03169.10 EFX05091.1 - 1.8e-156 522.2 37.8 7.6e-99 331.8 12.4 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein CcmD PF04995.9 EFX05091.1 - 6.7 6.5 7.9 5.4 6.8 1.8 3.0 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DIOX_N PF14226.1 EFX05092.1 - 6.1e-19 68.6 0.0 9.8e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX05092.1 - 3.7e-18 65.6 0.0 6.9e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-DHHC PF01529.15 EFX05093.1 - 6.4e-20 71.2 0.6 1.2e-19 70.3 0.2 1.7 1 1 0 1 1 1 1 DHHC palmitoyltransferase Pyr_redox_3 PF13738.1 EFX05094.1 - 4.6e-20 72.5 0.0 7e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX05094.1 - 1.3e-15 56.5 0.0 1.5e-12 46.4 0.0 2.4 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFX05094.1 - 1.9e-08 34.4 0.0 3.8e-08 33.4 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX05094.1 - 2.7e-07 29.8 0.0 1.3e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFX05094.1 - 2.8e-07 30.4 0.1 4e-06 26.7 0.0 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX05094.1 - 9.1e-06 24.8 0.6 0.025 13.4 0.0 3.2 3 2 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.12 EFX05094.1 - 0.00075 18.6 0.1 0.0018 17.4 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 EFX05094.1 - 0.0028 18.0 0.4 2.8 8.3 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX05094.1 - 0.012 14.4 0.0 0.021 13.6 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 EFX05094.1 - 0.12 12.1 7.0 2.6 7.7 0.1 4.2 4 1 0 4 4 4 0 FAD-NAD(P)-binding Shikimate_DH PF01488.15 EFX05094.1 - 0.12 12.5 0.2 14 5.7 0.0 3.3 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.7 EFX05094.1 - 0.42 9.4 2.5 0.26 10.1 0.1 2.0 2 1 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.9 EFX05094.1 - 0.55 8.6 1.6 1.1 7.5 0.4 1.9 2 0 0 2 2 2 0 HI0933-like protein Ribonuclease PF00545.15 EFX05096.1 - 3.4e-17 62.2 0.0 4.8e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 ribonuclease Pkinase PF00069.20 EFX05098.1 - 0.0021 17.2 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PAM2 PF07145.10 EFX05098.1 - 0.05 13.1 2.7 9.1 6.0 0.0 3.4 3 0 0 3 3 3 0 Ataxin-2 C-terminal region Sec2p PF06428.6 EFX05099.1 - 1.2e-19 69.9 16.1 1.2e-19 69.9 11.2 3.4 3 0 0 3 3 3 1 GDP/GTP exchange factor Sec2p Beta-lactamase PF00144.19 EFX05100.1 - 2e-45 155.2 1.7 4.3e-45 154.1 1.2 1.4 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.15 EFX05100.1 - 0.022 14.0 0.1 0.042 13.1 0.1 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase CFEM PF05730.6 EFX05101.1 - 2.1e-16 59.4 30.2 8.4e-09 35.1 6.2 2.7 1 1 2 3 3 3 2 CFEM domain BiPBP_C PF06832.7 EFX05102.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family p450 PF00067.17 EFX05103.1 - 2.7e-59 200.9 0.0 5.2e-59 199.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.14 EFX05104.1 - 2.8e-18 66.0 3.1 9.8e-17 61.0 2.1 2.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX05104.1 - 2.3e-07 30.0 0.0 1.6e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase SE PF08491.5 EFX05104.1 - 0.016 14.0 0.0 0.76 8.5 0.0 2.2 2 0 0 2 2 2 0 Squalene epoxidase Pyr_redox PF00070.22 EFX05104.1 - 0.091 13.1 2.0 0.27 11.6 1.4 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX05104.1 - 0.11 12.5 0.2 0.22 11.5 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 EFX05104.1 - 0.12 12.0 0.2 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-RING_5 PF14634.1 EFX05106.1 - 8e-09 35.0 6.5 1.1e-08 34.6 4.5 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFX05106.1 - 9.8e-09 35.1 7.6 1.4e-08 34.5 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX05106.1 - 1.6e-08 34.2 6.4 2.3e-08 33.7 4.4 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFX05106.1 - 2e-08 33.7 4.5 2.8e-08 33.3 3.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX05106.1 - 8.9e-06 25.2 5.1 1.3e-05 24.7 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 EFX05106.1 - 4.1e-05 23.2 4.6 6.3e-05 22.6 3.2 1.2 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.1 EFX05106.1 - 8e-05 22.1 7.5 0.00028 20.3 5.2 1.8 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 EFX05106.1 - 0.0016 17.9 4.3 0.0027 17.1 2.9 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.1 EFX05106.1 - 0.0039 16.8 0.5 0.015 15.0 0.4 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EFX05106.1 - 0.004 16.9 5.7 0.066 13.1 4.7 2.1 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 EFX05106.1 - 0.055 13.3 1.7 0.092 12.5 1.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EFX05106.1 - 0.057 13.5 1.8 0.096 12.8 1.2 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger DUF1272 PF06906.6 EFX05106.1 - 0.065 13.0 4.4 0.11 12.3 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zinc-ribbons_6 PF07191.7 EFX05106.1 - 0.092 12.5 2.4 0.2 11.4 1.7 1.5 1 1 0 1 1 1 0 zinc-ribbons DUF3279 PF11682.3 EFX05106.1 - 0.84 9.2 3.5 1.2 8.6 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) zf-P11 PF03854.9 EFX05106.1 - 0.97 8.9 5.5 3.2 7.2 3.9 1.7 1 1 0 1 1 1 0 P-11 zinc finger Cript PF10235.4 EFX05106.1 - 2.3 8.6 4.3 4.1 7.8 3.0 1.4 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Pyr_redox_3 PF13738.1 EFX05107.1 - 1.3e-23 84.0 0.0 4.9e-22 78.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX05107.1 - 7.8e-15 54.0 0.3 1.7e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFX05107.1 - 2.6e-13 49.6 0.0 9.6e-08 31.3 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFX05107.1 - 2.7e-11 43.3 0.0 5.5e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX05107.1 - 6.7e-09 35.7 0.0 2.3e-06 27.4 0.0 3.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.19 EFX05107.1 - 4.6e-06 25.7 0.0 0.0012 17.8 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX05107.1 - 4.7e-06 26.6 0.0 0.014 15.2 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FB_lectin PF07367.6 EFX05107.1 - 0.033 13.7 0.3 0.073 12.6 0.2 1.5 1 0 0 1 1 1 0 Fungal fruit body lectin LBR_tudor PF09465.5 EFX05107.1 - 0.065 12.8 2.1 0.13 11.9 0.0 2.5 3 0 0 3 3 3 0 Lamin-B receptor of TUDOR domain Shikimate_DH PF01488.15 EFX05107.1 - 0.072 13.1 0.0 0.98 9.5 0.0 2.5 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_1 PF00667.15 EFX05108.1 - 3.6e-41 141.0 0.0 5.5e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EFX05108.1 - 4.8e-22 78.5 0.0 7.1e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EFX05108.1 - 1.5e-16 60.9 0.0 9.4e-16 58.3 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Fungal_trans PF04082.13 EFX05109.1 - 2.6e-11 42.8 0.2 7.1e-11 41.4 0.1 1.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain EGF_MSP1_1 PF12946.2 EFX05109.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 MSP1 EGF domain 1 Dynamin_N PF00350.18 EFX05112.1 - 1.4e-36 125.8 0.1 3.8e-36 124.4 0.0 1.8 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 EFX05112.1 - 1.8e-13 49.9 0.2 3.6e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Dynamin central region GED PF02212.13 EFX05112.1 - 0.00024 20.9 2.2 0.0027 17.5 0.0 3.3 4 0 0 4 4 4 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EFX05112.1 - 0.00032 20.6 0.0 0.0021 17.9 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFX05112.1 - 0.018 15.5 0.0 0.078 13.4 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein AAA_21 PF13304.1 EFX05112.1 - 0.099 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain KorB PF08535.5 EFX05112.1 - 0.12 12.5 0.3 0.49 10.5 0.0 2.2 2 1 1 3 3 3 0 KorB domain AAA_29 PF13555.1 EFX05112.1 - 0.14 11.6 0.0 0.39 10.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain HMG_box PF00505.14 EFX05114.1 - 1e-20 73.7 0.1 1.5e-20 73.2 0.1 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EFX05114.1 - 1.4e-06 28.5 0.0 2.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain Glyco_hydro_3 PF00933.16 EFX05115.1 - 2.8e-83 279.3 0.0 4.5e-83 278.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX05115.1 - 1.7e-62 210.9 0.5 7.7e-62 208.7 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX05115.1 - 1.5e-20 72.8 0.3 3.4e-20 71.7 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EFX05115.1 - 0.00078 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.6 EFX05115.1 - 0.0059 16.6 0.1 0.018 15.0 0.1 1.8 1 0 0 1 1 1 1 CARDB Fungal_trans PF04082.13 EFX05116.1 - 5.2e-39 133.6 0.1 8.3e-39 133.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EFX05116.1 - 1.3e-07 31.4 12.3 0.0011 19.1 1.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX05116.1 - 2.6e-06 27.3 18.0 0.0011 19.1 2.0 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger Pkinase PF00069.20 EFX05117.1 - 1.2e-40 139.3 0.1 1.3e-24 86.7 0.1 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05117.1 - 8.9e-14 51.1 0.5 2.6e-09 36.5 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Methyltransf_23 PF13489.1 EFX05118.1 - 6.1e-20 71.5 0.0 9.3e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05118.1 - 6.5e-14 52.1 0.0 1.4e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05118.1 - 3.5e-09 36.4 0.0 0.00043 19.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05118.1 - 1.2e-08 35.3 0.0 1.7e-07 31.6 0.0 2.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05118.1 - 8.5e-07 29.5 0.0 1.9e-05 25.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05118.1 - 9.9e-07 29.0 0.0 3.3e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX05118.1 - 1.4e-06 27.5 0.1 2.2e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.10 EFX05118.1 - 0.0089 15.6 0.0 0.057 13.0 0.0 2.0 1 1 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_16 PF10294.4 EFX05118.1 - 0.0094 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX05118.1 - 0.019 15.0 0.0 0.058 13.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EFX05118.1 - 0.019 14.0 0.0 0.099 11.6 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase PrmA PF06325.8 EFX05118.1 - 0.047 12.8 0.0 0.11 11.6 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.10 EFX05118.1 - 0.073 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_2 PF00891.13 EFX05118.1 - 0.078 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase FtsJ PF01728.14 EFX05118.1 - 0.096 12.6 0.0 0.2 11.6 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase NAD_binding_8 PF13450.1 EFX05119.1 - 5.7e-09 35.8 0.0 1.3e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EFX05119.1 - 3.8e-08 32.8 0.4 1.2e-07 31.1 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.19 EFX05119.1 - 2.8e-07 29.7 0.5 8e-07 28.2 0.4 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX05119.1 - 5.6e-07 28.7 0.2 9.8e-07 27.9 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EFX05119.1 - 0.00015 20.9 0.3 0.00029 20.0 0.2 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 EFX05119.1 - 0.00027 19.5 0.1 0.00041 18.9 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 EFX05119.1 - 0.00028 20.0 0.1 0.0005 19.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX05119.1 - 0.00054 19.8 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EFX05119.1 - 0.00068 19.9 0.4 0.0022 18.3 0.0 2.0 2 1 1 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX05119.1 - 0.00097 18.0 0.1 0.0015 17.5 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 EFX05119.1 - 0.0026 17.8 0.1 0.0089 16.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EFX05119.1 - 0.015 14.2 0.0 0.021 13.7 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.9 EFX05119.1 - 0.016 13.9 0.4 0.027 13.1 0.3 1.3 1 0 0 1 1 1 0 Tryptophan halogenase IlvN PF07991.7 EFX05119.1 - 0.039 13.3 0.1 0.084 12.2 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Glyco_hydro_18 PF00704.23 EFX05124.1 - 3.4e-57 194.4 3.5 6.7e-57 193.4 2.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 EFX05124.1 - 3e-29 100.6 1.4 1.6e-05 24.6 0.0 4.7 4 0 0 4 4 4 4 LysM domain DUF3142 PF11340.3 EFX05124.1 - 0.0041 16.7 0.0 0.0078 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3142) HTH_23 PF13384.1 EFX05124.1 - 0.029 14.0 0.1 9.9 5.9 0.0 3.5 4 0 0 4 4 4 0 Homeodomain-like domain TetR_N PF00440.18 EFX05124.1 - 0.12 12.0 0.2 44 3.8 0.0 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family F-box PF00646.28 EFX05125.1 - 6.3e-05 22.5 0.1 0.00029 20.4 0.1 2.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EFX05125.1 - 0.0036 16.9 0.0 0.018 14.7 0.0 2.3 1 0 0 1 1 1 1 F-box-like FAD_binding_4 PF01565.18 EFX05126.1 - 1.7e-14 53.4 3.5 1e-13 50.9 2.4 2.1 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.7 EFX05126.1 - 0.0024 17.7 0.0 0.009 15.9 0.0 2.0 1 0 0 1 1 1 1 Berberine and berberine like DLH PF01738.13 EFX05126.1 - 0.12 11.6 0.2 1.8 7.7 0.3 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Glyco_hydro_17 PF00332.13 EFX05128.1 - 1.4e-09 37.4 0.6 2.9e-07 29.8 0.1 2.4 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 F-box-like PF12937.2 EFX05129.1 - 8.9e-08 31.7 0.5 2.4e-07 30.3 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX05129.1 - 3e-07 29.9 0.3 6.8e-07 28.7 0.2 1.7 1 0 0 1 1 1 1 F-box domain DSHCT PF08148.7 EFX05130.1 - 3.7e-49 166.3 0.3 6.4e-49 165.6 0.2 1.4 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 EFX05130.1 - 7.9e-20 71.0 0.1 1.6e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX05130.1 - 3.1e-07 30.1 0.0 7.1e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX05130.1 - 0.0036 17.1 0.1 0.011 15.5 0.1 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit BUD22 PF09073.5 EFX05130.1 - 0.18 10.8 12.3 0.27 10.2 8.6 1.2 1 0 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.7 EFX05130.1 - 0.69 9.5 14.0 1.3 8.6 9.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.7 EFX05130.1 - 2.8 6.1 16.1 4.3 5.5 11.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Methyltransf_23 PF13489.1 EFX05131.1 - 0.00017 21.3 0.0 0.0054 16.4 0.0 2.2 2 1 0 2 2 2 2 Methyltransferase domain GTP_cyclohydroI PF01227.17 EFX05132.1 - 2.5e-73 245.1 0.1 3.2e-73 244.8 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 EFX05132.1 - 0.0046 16.8 0.0 0.0081 16.0 0.0 1.3 1 0 0 1 1 1 1 QueF-like protein Transp_cyt_pur PF02133.10 EFX05133.1 - 5e-27 94.5 30.9 7e-27 94.0 21.4 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1049 PF06305.6 EFX05133.1 - 0.82 9.1 13.2 0.32 10.4 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) CN_hydrolase PF00795.17 EFX05134.1 - 1.5e-19 70.0 0.0 6.4e-19 68.0 0.0 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase DUF2296 PF10058.4 EFX05136.1 - 1.4e-17 63.1 0.1 2.2e-17 62.5 0.1 1.3 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) Swi3 PF07962.7 EFX05138.1 - 1.5e-28 98.2 0.2 2.3e-28 97.6 0.1 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Asp_Glu_race PF01177.17 EFX05141.1 - 4.8e-23 82.2 0.4 5.8e-23 81.9 0.3 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Glyco_hydro_18 PF00704.23 EFX05142.1 - 2.8e-41 142.0 0.4 6.1e-40 137.7 0.3 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 EFX05142.1 - 1.7e-05 24.7 22.9 0.00012 22.0 16.1 2.2 1 1 1 2 2 2 1 Chitin recognition protein MFS_1 PF07690.11 EFX05143.1 - 7.2e-46 156.5 48.6 1.2e-45 155.7 33.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Snf7 PF03357.16 EFX05144.1 - 1.5e-05 24.4 24.0 1.5e-05 24.4 16.6 1.5 1 1 1 2 2 2 1 Snf7 Ashwin PF15323.1 EFX05144.1 - 0.83 9.6 6.5 1.2 9.0 4.5 1.2 1 0 0 1 1 1 0 Developmental protein p450 PF00067.17 EFX05145.1 - 1.4e-61 208.4 0.0 1.8e-61 208.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NADH-u_ox-rdase PF10785.4 EFX05146.1 - 3.9e-35 119.9 0.2 7.7e-35 119.0 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.2 EFX05146.1 - 4e-31 106.5 0.0 5.7e-31 106.0 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Fumerase_C PF05683.7 EFX05146.1 - 0.027 13.5 0.2 0.065 12.3 0.0 1.6 2 0 0 2 2 2 0 Fumarase C-terminus Asparaginase PF00710.15 EFX05147.1 - 4.7e-59 199.8 0.7 5.4e-59 199.5 0.5 1.0 1 0 0 1 1 1 1 Asparaginase Glucosamine_iso PF01182.15 EFX05148.1 - 2.2e-24 86.2 0.0 3.3e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.8 EFX05148.1 - 0.023 13.5 0.1 0.045 12.6 0.1 1.4 1 0 0 1 1 1 0 Putative sugar-binding domain Glyco_hydro_15 PF00723.16 EFX05149.1 - 2.1e-100 336.4 2.0 2.5e-100 336.1 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.14 EFX05149.1 - 1.4e-33 114.3 0.2 3.8e-33 112.9 0.1 1.8 1 0 0 1 1 1 1 Starch binding domain CBM_25 PF03423.8 EFX05149.1 - 0.039 14.0 0.0 0.097 12.7 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) Phage_Gp19 PF09355.5 EFX05149.1 - 0.077 12.8 0.1 9.1 6.1 0.0 2.8 1 1 1 2 2 2 0 Phage protein Gp19/Gp15/Gp42 MFS_1 PF07690.11 EFX05151.1 - 6e-27 94.2 35.5 8.7e-16 57.5 5.9 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05151.1 - 1.4e-06 27.1 1.7 1.4e-06 27.1 1.2 2.9 2 2 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.8 EFX05151.1 - 0.0005 18.3 1.7 0.0061 14.8 1.1 2.0 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AA_permease PF00324.16 EFX05152.1 - 6.8e-91 304.9 36.6 7.8e-91 304.7 25.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX05152.1 - 3.7e-15 55.3 41.5 4.9e-15 54.9 28.8 1.0 1 0 0 1 1 1 1 Amino acid permease TMEM173 PF15009.1 EFX05152.1 - 1.7 7.3 3.2 2.1 7.0 0.3 2.1 1 1 1 2 2 2 0 Transmembrane protein 173 NmrA PF05368.8 EFX05154.1 - 2.3e-19 69.5 0.0 3e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX05154.1 - 1.6e-13 51.0 0.8 6.5e-13 49.0 0.5 2.0 1 1 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EFX05154.1 - 0.19 11.3 1.7 0.41 10.2 1.2 1.5 1 0 0 1 1 1 0 KR domain adh_short PF00106.20 EFX05154.1 - 0.24 11.3 8.2 0.041 13.8 2.6 2.0 3 0 0 3 3 3 0 short chain dehydrogenase GRIP PF01465.15 EFX05155.1 - 1.5e-13 50.0 0.0 3.1e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 GRIP domain GAS PF13851.1 EFX05155.1 - 4.4e-06 26.0 105.5 0.00084 18.5 14.0 7.0 3 1 4 7 7 7 4 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.16 EFX05155.1 - 0.003 17.4 2.2 0.003 17.4 1.5 11.0 7 3 5 12 12 12 2 bZIP transcription factor CENP-Q PF13094.1 EFX05155.1 - 0.0038 17.2 20.5 0.0038 17.2 14.2 7.1 2 2 4 6 6 6 2 CENP-Q, a CENPA-CAD centromere complex subunit TMF_DNA_bd PF12329.3 EFX05155.1 - 0.0094 15.7 3.8 0.0094 15.7 2.6 11.5 5 3 4 11 11 11 3 TATA element modulatory factor 1 DNA binding Reo_sigmaC PF04582.7 EFX05155.1 - 0.02 14.0 35.3 0.13 11.4 3.3 5.6 4 2 2 6 6 6 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 EFX05155.1 - 5.1 7.0 22.1 0.4 10.5 0.8 5.7 6 1 1 7 7 7 0 Flagella accessory protein C (FlaC) HLH PF00010.21 EFX05156.1 - 1e-16 60.3 0.0 1.7e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Aldo_ket_red PF00248.16 EFX05157.1 - 5e-63 212.5 0.0 5.7e-63 212.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.27 EFX05158.1 - 6.1e-28 95.6 6.7 1.4e-12 46.9 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat GMC_oxred_N PF00732.14 EFX05159.1 - 1.9e-46 158.5 0.0 2.5e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX05159.1 - 1.5e-38 132.3 0.0 2.3e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EFX05159.1 - 2e-05 23.6 0.3 0.0012 17.8 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFX05159.1 - 5.2e-05 22.3 0.0 8.5e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFX05159.1 - 0.00064 19.6 0.0 0.0019 18.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX05159.1 - 0.0041 16.0 0.1 0.36 9.6 0.0 2.5 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX05159.1 - 0.019 14.8 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX05159.1 - 0.037 12.6 0.0 0.054 12.1 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase bZIP_2 PF07716.10 EFX05160.1 - 6.3e-07 29.1 17.3 1.7e-06 27.7 12.0 1.8 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EFX05160.1 - 0.00067 19.5 14.5 0.0013 18.6 10.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.12 EFX05160.1 - 0.087 13.1 10.2 0.19 12.0 7.0 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor RR_TM4-6 PF06459.7 EFX05160.1 - 0.15 11.8 5.3 0.25 11.2 3.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MFS_1 PF07690.11 EFX05161.1 - 4.5e-28 97.9 26.3 4.5e-28 97.9 18.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily YcxB PF14317.1 EFX05161.1 - 0.028 13.6 0.1 0.059 12.6 0.0 1.5 1 0 0 1 1 1 0 YcxB-like protein VIT1 PF01988.14 EFX05161.1 - 0.12 11.8 0.0 0.12 11.8 0.0 2.2 2 1 0 2 2 2 0 VIT family DUF4231 PF14015.1 EFX05161.1 - 3 7.8 12.5 3.3 7.7 0.1 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF4231) Fungal_trans PF04082.13 EFX05162.1 - 3.9e-15 55.4 0.0 6.1e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05162.1 - 0.00039 20.2 7.0 0.00099 18.9 4.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dynamin_N PF00350.18 EFX05163.1 - 1.3e-14 54.4 0.0 4.2e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 Dynamin family DUF258 PF03193.11 EFX05163.1 - 4.9e-07 29.0 0.0 1.5e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EFX05163.1 - 3e-06 27.1 0.0 0.00037 20.4 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 EFX05163.1 - 0.00022 21.2 2.4 0.00081 19.4 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 EFX05163.1 - 0.0028 17.9 0.0 0.0077 16.5 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_17 PF13207.1 EFX05163.1 - 0.005 17.6 0.1 0.029 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sec20 PF03908.8 EFX05163.1 - 0.012 15.2 0.9 0.052 13.2 0.2 2.6 2 0 0 2 2 2 0 Sec20 AAA_29 PF13555.1 EFX05163.1 - 0.029 13.8 0.0 0.072 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX05163.1 - 0.035 14.4 0.0 0.12 12.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.10 EFX05163.1 - 0.1 11.2 0.0 0.21 10.1 0.0 1.5 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_21 PF13304.1 EFX05163.1 - 0.14 12.0 0.0 0.41 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EFX05163.1 - 0.36 10.2 3.3 1.8 7.9 0.4 2.8 2 1 0 2 2 2 0 AAA-like domain WD40 PF00400.27 EFX05165.1 - 9.1e-19 66.5 1.0 0.00051 19.8 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat Pol_alpha_B_N PF08418.5 EFX05165.1 - 6.2 6.2 9.0 14 5.0 6.3 1.6 1 1 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Alpha-amylase PF00128.19 EFX05166.1 - 3.6e-74 250.0 0.2 5e-74 249.5 0.2 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain CBM_20 PF00686.14 EFX05166.1 - 7.4e-33 112.0 0.5 1.9e-32 110.7 0.3 1.7 1 0 0 1 1 1 1 Starch binding domain DUF1966 PF09260.6 EFX05166.1 - 1.1e-27 95.9 1.4 5.4e-27 93.7 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1966) Glyco_hydro_76 PF03663.9 EFX05167.1 - 6.7e-42 144.1 14.2 6.7e-42 144.1 9.9 1.4 1 1 1 2 2 2 1 Glycosyl hydrolase family 76 Glyco_hydro_9 PF00759.14 EFX05167.1 - 9.6e-05 21.4 7.5 0.031 13.1 2.0 2.2 1 1 0 2 2 2 2 Glycosyl hydrolase family 9 DUF1680 PF07944.7 EFX05167.1 - 0.00038 18.8 0.2 0.016 13.5 0.0 2.1 1 1 0 2 2 2 2 Putative glycosyl hydrolase of unknown function (DUF1680) Glyco_hydro_88 PF07470.8 EFX05167.1 - 0.00049 19.2 2.1 0.033 13.2 0.0 3.0 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 DUF3042 PF11240.3 EFX05167.1 - 0.22 11.3 0.5 5.3 6.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) TauD PF02668.11 EFX05168.1 - 2.8e-35 122.2 0.1 3.4e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CRAL_TRIO_2 PF13716.1 EFX05168.1 - 0.058 13.3 0.0 0.35 10.7 0.0 2.0 1 1 1 2 2 2 0 Divergent CRAL/TRIO domain MFS_1 PF07690.11 EFX05169.1 - 4.8e-39 134.0 43.4 2.6e-38 131.6 29.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05169.1 - 1e-13 50.7 9.2 1e-13 50.7 6.3 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter Zn_clus PF00172.13 EFX05170.1 - 0.0004 20.2 12.4 0.00063 19.6 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EFX05171.1 - 1.3e-21 76.7 18.6 1.6e-21 76.4 12.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1212 PF06738.7 EFX05171.1 - 0.7 9.3 3.8 2.4 7.5 2.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1212) Fungal_trans_2 PF11951.3 EFX05174.1 - 7.6e-30 103.7 0.3 3.2e-29 101.7 0.2 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain F-box PF00646.28 EFX05175.1 - 0.00071 19.1 0.0 0.0022 17.6 0.0 1.9 2 0 0 2 2 2 1 F-box domain Zn_clus PF00172.13 EFX05176.1 - 1.2e-06 28.3 9.5 1.9e-06 27.6 6.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexokinase_1 PF00349.16 EFX05177.1 - 6.2e-54 182.4 0.0 9.5e-54 181.8 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 EFX05177.1 - 2.7e-52 177.4 0.2 5e-41 140.5 0.0 2.1 2 0 0 2 2 2 2 Hexokinase adh_short_C2 PF13561.1 EFX05178.1 - 7.3e-29 101.2 0.0 8.5e-29 101.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX05178.1 - 6.6e-24 84.7 0.8 8.6e-24 84.3 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX05178.1 - 3.7e-12 46.2 0.1 5.7e-12 45.6 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX05178.1 - 1.7e-06 27.6 0.1 3.1e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Dak1_2 PF13684.1 EFX05178.1 - 0.1 11.5 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Dihydroxyacetone kinase family ETF PF01012.16 EFX05178.1 - 0.13 11.9 0.7 0.25 11.0 0.5 1.5 1 0 0 1 1 1 0 Electron transfer flavoprotein domain Pex16 PF08610.5 EFX05179.1 - 3.3e-88 295.8 0.0 9.8e-88 294.3 0.0 1.7 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Totivirus_coat PF05518.6 EFX05179.1 - 0.075 10.8 3.9 0.1 10.4 2.7 1.1 1 0 0 1 1 1 0 Totivirus coat protein MGC-24 PF05283.6 EFX05179.1 - 4.6 6.9 7.1 13 5.4 4.9 1.7 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) zf-C4H2 PF10146.4 EFX05179.1 - 4.6 7.1 5.5 13 5.7 3.8 1.7 1 0 0 1 1 1 0 Zinc finger-containing protein Aldedh PF00171.17 EFX05180.1 - 8.3e-150 499.1 0.0 9.8e-150 498.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_trans_2 PF11951.3 EFX05181.1 - 7.3e-05 21.5 1.0 9.3e-05 21.1 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.21 EFX05182.1 - 3.5e-29 100.9 0.6 4.8e-28 97.2 0.1 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX05182.1 - 2.6e-14 54.2 2.0 2.8e-14 54.1 0.1 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX05182.1 - 5.1e-10 39.0 0.0 1.5e-09 37.5 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF3628 PF12300.3 EFX05183.1 - 0.0051 16.8 3.7 0.0093 16.0 2.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3628) SRR1 PF07985.7 EFX05183.1 - 0.059 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 SRR1 NMT1 PF09084.6 EFX05184.1 - 1.2e-73 247.3 0.0 1.6e-73 246.8 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 EFX05184.1 - 1.8e-09 37.3 0.2 0.0017 17.7 0.1 3.6 2 1 2 4 4 4 3 NMT1-like family Dak1 PF02733.12 EFX05184.1 - 0.026 13.0 0.0 0.04 12.4 0.0 1.2 1 0 0 1 1 1 0 Dak1 domain Phosphonate-bd PF12974.2 EFX05184.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Sugar_tr PF00083.19 EFX05185.1 - 1.1e-127 426.3 29.9 1.3e-127 426.1 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05185.1 - 3.7e-20 71.9 44.5 6.7e-15 54.6 14.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily AA_permease_2 PF13520.1 EFX05186.1 - 5.1e-55 186.7 50.0 6.2e-55 186.4 34.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX05186.1 - 9.5e-22 76.9 43.6 1.2e-21 76.6 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease PUL PF08324.6 EFX05187.1 - 2.8e-36 124.7 0.0 5.1e-36 123.8 0.0 1.4 1 1 0 1 1 1 1 PUL domain WD40 PF00400.27 EFX05187.1 - 1.1e-26 91.7 19.3 1.4e-07 31.0 0.6 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat PFU PF09070.6 EFX05187.1 - 6.8e-09 35.7 0.2 1.2e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) NmrA PF05368.8 EFX05188.1 - 6.1e-21 74.7 0.0 7.9e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX05188.1 - 9.5e-15 55.0 0.0 1.4e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EFX05188.1 - 0.021 14.7 0.4 0.048 13.5 0.0 1.7 2 0 0 2 2 2 0 short chain dehydrogenase SWIRM PF04433.12 EFX05189.1 - 3.2e-14 52.8 0.1 7.7e-13 48.3 0.0 2.3 2 0 0 2 2 2 1 SWIRM domain PAT1 PF09770.4 EFX05189.1 - 0.33 9.1 16.4 0.38 8.9 11.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.8 EFX05189.1 - 0.43 9.3 6.2 0.63 8.8 4.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor OPT PF03169.10 EFX05190.1 - 1.9e-177 591.5 55.8 2.1e-177 591.3 38.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.1 EFX05190.1 - 0.021 13.9 0.6 0.073 12.1 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) BofA PF07441.6 EFX05190.1 - 0.047 13.6 7.7 0.097 12.6 2.0 3.1 2 0 0 2 2 2 0 SigmaK-factor processing regulatory protein BofA Glyco_hydro_2_N PF02837.13 EFX05191.1 - 7.9e-26 90.5 0.0 8.6e-26 90.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_16 PF00722.16 EFX05192.1 - 8.9e-42 142.4 3.9 1.7e-41 141.5 2.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Myb_DNA-bind_6 PF13921.1 EFX05193.1 - 3.7e-05 23.7 0.2 0.0019 18.2 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFX05193.1 - 0.017 15.1 0.5 0.57 10.2 0.2 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain Glyco_transf_15 PF01793.11 EFX05194.1 - 1.9e-130 434.6 0.2 2.5e-130 434.2 0.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Myb_DNA-binding PF00249.26 EFX05195.1 - 1.9e-07 31.0 0.6 6.1e-07 29.3 0.4 1.9 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX05195.1 - 3.7e-06 26.9 0.0 7.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain cwf18 PF08315.7 EFX05195.1 - 0.31 11.5 4.3 0.56 10.6 3.0 1.4 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor PAT1 PF09770.4 EFX05195.1 - 4.3 5.4 38.4 5.9 5.0 26.6 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Chs3p PF12271.3 EFX05196.1 - 5e-136 452.4 14.1 5.6e-136 452.2 9.8 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit DUF3382 PF11862.3 EFX05196.1 - 0.46 10.4 8.7 0.051 13.4 2.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) COPIIcoated_ERV PF07970.7 EFX05200.1 - 2.7e-70 236.4 0.0 2e-68 230.3 0.0 2.2 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EFX05200.1 - 1.2e-34 118.1 0.0 3.2e-34 116.7 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Acetyltransf_1 PF00583.19 EFX05202.1 - 5.1e-07 29.6 0.0 9.8e-07 28.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX05202.1 - 1.9e-06 27.9 0.0 3.1e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFX05202.1 - 0.00018 21.5 0.1 0.0016 18.5 0.0 2.1 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFX05202.1 - 0.014 15.5 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX05202.1 - 0.028 14.1 0.0 0.081 12.6 0.0 1.8 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.1 EFX05202.1 - 0.044 13.6 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NDT80_PhoG PF05224.7 EFX05204.1 - 9.2e-46 156.1 0.3 1.3e-43 149.2 0.0 2.1 2 0 0 2 2 2 2 NDT80 / PhoG like DNA-binding family Kinesin PF00225.18 EFX05205.1 - 2.9e-82 276.0 0.0 4.1e-82 275.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain DUF1690 PF07956.6 EFX05205.1 - 0.0028 17.6 0.8 0.0076 16.2 0.5 1.7 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) DUF3701 PF12482.3 EFX05205.1 - 0.0099 15.5 0.0 0.034 13.8 0.0 1.9 1 0 0 1 1 1 1 Phage integrase protein HHH PF00633.18 EFX05205.1 - 0.016 14.8 0.0 6 6.7 0.0 2.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif Malic_M PF03949.10 EFX05206.1 - 1.6e-84 283.4 0.0 4.1e-84 282.1 0.0 1.6 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EFX05206.1 - 5.3e-69 231.4 0.0 9e-69 230.6 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Cerato-platanin PF07249.7 EFX05207.1 - 0.00049 20.0 0.8 0.00089 19.2 0.1 1.9 2 0 0 2 2 2 1 Cerato-platanin RNA_pol_Rpb2_6 PF00562.23 EFX05208.1 - 6e-115 384.0 0.0 8e-115 383.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EFX05208.1 - 6.6e-31 106.8 0.0 1e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.11 EFX05208.1 - 4e-25 87.3 0.0 9.5e-25 86.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 EFX05208.1 - 8.5e-25 86.4 0.0 2e-24 85.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.9 EFX05208.1 - 1.1e-23 83.6 0.0 1.9e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 EFX05208.1 - 3.2e-14 52.9 0.0 5.8e-13 48.9 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 EFX05208.1 - 0.0003 20.7 0.0 0.00067 19.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 zf-HIT PF04438.11 EFX05209.1 - 1.3e-09 37.5 4.3 2e-09 36.9 3.0 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.19 EFX05209.1 - 4.9 7.1 7.0 15 5.5 4.8 1.8 1 1 0 1 1 1 0 B-box zinc finger DHC_N1 PF08385.7 EFX05210.1 - 1.9e-190 634.1 4.4 4.4e-190 632.9 0.0 3.5 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 EFX05210.1 - 1.3e-129 432.2 0.7 1.3e-129 432.2 0.5 4.1 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 Dynein_heavy PF03028.10 EFX05210.1 - 1.1e-92 311.2 0.0 2.2e-92 310.2 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_6 PF12774.2 EFX05210.1 - 7e-77 258.0 0.0 1.6e-76 256.8 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 EFX05210.1 - 2.8e-43 147.3 0.0 5.9e-43 146.3 0.0 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 EFX05210.1 - 1.2e-41 142.6 3.4 1.2e-41 142.6 2.4 1.9 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.2 EFX05210.1 - 1.4e-40 139.0 0.0 1.4e-39 135.6 0.0 2.5 2 1 0 2 2 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.9 EFX05210.1 - 1.6e-31 108.8 0.0 2.2e-11 43.6 0.0 5.9 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_7 PF12775.2 EFX05210.1 - 7.7e-20 71.0 0.0 2.1e-18 66.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 PAP2 PF01569.16 EFX05210.1 - 1.6e-17 63.3 0.8 3.7e-17 62.2 0.5 1.6 1 0 0 1 1 1 1 PAP2 superfamily AAA_22 PF13401.1 EFX05210.1 - 2.4e-15 56.8 0.1 0.023 14.8 0.1 6.7 6 1 0 6 6 5 3 AAA domain AAA PF00004.24 EFX05210.1 - 7.8e-14 51.9 0.0 0.0017 18.5 0.0 4.7 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EFX05210.1 - 3.4e-12 46.4 1.4 0.015 15.1 0.0 6.8 5 0 0 5 5 5 3 AAA domain AAA_17 PF13207.1 EFX05210.1 - 1.4e-11 45.2 0.1 0.029 15.1 0.0 5.5 4 0 0 4 4 4 2 AAA domain AAA_18 PF13238.1 EFX05210.1 - 8.9e-10 38.9 0.1 0.047 13.9 0.0 4.6 4 0 0 4 4 4 2 AAA domain T2SE PF00437.15 EFX05210.1 - 1.2e-07 30.9 0.0 0.052 12.4 0.0 3.9 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_14 PF13173.1 EFX05210.1 - 2.6e-06 27.3 0.0 0.48 10.3 0.0 4.2 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 EFX05210.1 - 4.2e-06 26.1 0.0 0.51 9.9 0.0 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain Mg_chelatase PF01078.16 EFX05210.1 - 1.1e-05 24.7 0.5 0.55 9.3 0.0 4.1 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 EFX05210.1 - 0.00011 22.4 0.0 4.4 7.6 0.0 4.2 3 0 0 3 3 3 0 ABC transporter Zeta_toxin PF06414.7 EFX05210.1 - 0.00056 19.0 4.6 1.1 8.3 0.0 4.4 4 0 0 4 4 3 2 Zeta toxin BRE1 PF08647.6 EFX05210.1 - 0.0019 18.1 0.3 0.0019 18.1 0.2 3.4 3 0 0 3 3 1 1 BRE1 E3 ubiquitin ligase MobB PF03205.9 EFX05210.1 - 0.007 16.0 0.3 12 5.6 0.0 3.5 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 EFX05210.1 - 0.011 14.9 0.0 20 4.3 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function, DUF258 NTPase_1 PF03266.10 EFX05210.1 - 0.016 14.9 0.1 27 4.4 0.0 4.0 3 0 0 3 3 3 0 NTPase RNA_helicase PF00910.17 EFX05210.1 - 0.017 15.2 0.3 24 5.1 0.0 4.3 4 0 0 4 4 4 0 RNA helicase Viral_helicase1 PF01443.13 EFX05210.1 - 0.024 14.1 0.0 7.2 6.0 0.0 3.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.1 EFX05210.1 - 0.12 11.9 0.8 32 4.0 0.0 4.5 5 0 0 5 5 5 0 AAA domain PduV-EutP PF10662.4 EFX05210.1 - 0.18 11.3 0.8 7.8 5.9 0.1 3.8 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation AAA_11 PF13086.1 EFX05210.1 - 0.81 9.2 6.1 3.8 7.0 0.0 4.1 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.15 EFX05210.1 - 0.94 8.0 0.2 55 2.2 0.0 3.1 3 0 0 3 3 2 0 G-protein alpha subunit AAA_10 PF12846.2 EFX05210.1 - 1 8.7 8.5 14 5.0 0.2 5.1 4 1 0 4 4 3 0 AAA-like domain DUF87 PF01935.12 EFX05210.1 - 2.6 7.7 6.5 2.7 7.7 0.0 4.1 4 0 0 4 4 2 0 Domain of unknown function DUF87 AAA_23 PF13476.1 EFX05210.1 - 7.1 6.8 8.7 59 3.9 0.0 5.4 5 0 0 5 5 5 0 AAA domain Atg14 PF10186.4 EFX05210.1 - 7.4 5.4 17.3 1.3 7.9 3.4 3.5 3 0 0 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 GDI PF00996.13 EFX05211.1 - 4.9e-183 608.4 0.0 6e-183 608.1 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor zf-UDP PF14569.1 EFX05211.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger Kinetochor_Ybp2 PF08568.5 EFX05212.1 - 4.1e-101 339.1 0.0 5.9e-71 239.5 0.0 2.3 2 1 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin KKLCAg1 PF15204.1 EFX05212.1 - 0.0021 18.0 0.0 0.0055 16.7 0.0 1.7 1 0 0 1 1 1 1 Kita-kyushu lung cancer antigen 1 SNF2_N PF00176.18 EFX05213.1 - 7.6e-71 238.3 0.2 1.5e-70 237.3 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX05213.1 - 6e-15 54.8 0.0 1.8e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX05213.1 - 2.3e-05 24.2 0.2 0.00012 21.9 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Palm_thioest PF02089.10 EFX05214.1 - 2.9e-52 177.3 0.0 3.6e-52 177.0 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.2 EFX05214.1 - 0.00041 20.3 0.1 0.00054 19.9 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 EFX05214.1 - 0.026 13.6 0.0 0.045 12.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Tho2 PF11262.3 EFX05215.1 - 4.6e-71 239.3 0.0 8.4e-71 238.4 0.0 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 EFX05215.1 - 1.1e-25 89.2 0.0 2.6e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Lactonase PF10282.4 EFX05216.1 - 0.15 11.1 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Complex1_LYR PF05347.10 EFX05217.1 - 1.1e-16 60.3 0.3 3.3e-15 55.6 0.0 2.1 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFX05217.1 - 4.9e-16 58.6 0.2 8.5e-15 54.7 0.0 2.0 2 0 0 2 2 2 1 Complex1_LYR-like Aldo_ket_red PF00248.16 EFX05219.1 - 7.9e-46 156.1 0.0 1.1e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family B12-binding PF02310.14 EFX05219.1 - 0.099 12.5 0.0 0.53 10.1 0.0 1.9 2 0 0 2 2 2 0 B12 binding domain Ku PF02735.11 EFX05220.1 - 1.2e-39 135.8 0.0 4.1e-39 134.0 0.0 1.8 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 EFX05220.1 - 1.5e-25 89.9 0.0 2.8e-24 85.7 0.0 2.2 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.9 EFX05220.1 - 1.7e-13 50.9 0.1 4.3e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.22 EFX05220.1 - 5.9e-08 32.0 0.1 1.7e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 SAP domain Toprim_3 PF13362.1 EFX05220.1 - 0.017 15.3 0.0 0.059 13.6 0.0 1.9 1 0 0 1 1 1 0 Toprim domain BCS1_N PF08740.6 EFX05221.1 - 1.9e-51 174.3 1.3 1.9e-51 174.3 0.9 2.7 3 1 0 3 3 3 1 BCS1 N terminal AAA PF00004.24 EFX05221.1 - 7.3e-17 61.8 0.0 7.9e-08 32.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFX05221.1 - 0.00082 18.8 0.0 0.0018 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFX05221.1 - 0.00085 19.0 0.0 0.0058 16.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFX05221.1 - 0.0017 18.3 0.3 0.0081 16.1 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EFX05221.1 - 0.0022 18.8 0.4 0.026 15.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EFX05221.1 - 0.0064 16.2 0.0 0.044 13.5 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain RuvB_N PF05496.7 EFX05221.1 - 0.03 13.3 0.0 0.054 12.5 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus PPV_E1_C PF00519.12 EFX05221.1 - 0.042 12.4 0.0 0.1 11.2 0.0 1.6 1 0 0 1 1 1 0 Papillomavirus helicase TFIIF_alpha PF05793.7 EFX05221.1 - 0.84 7.9 64.5 0.0078 14.6 20.8 3.1 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cu_amine_oxid PF01179.15 EFX05222.1 - 5.4e-159 529.3 0.0 7.6e-159 528.8 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Prefoldin_2 PF01920.15 EFX05222.1 - 1.2e-21 76.4 4.4 2.5e-21 75.4 3.0 1.5 1 0 0 1 1 1 1 Prefoldin subunit Cu_amine_oxidN2 PF02727.11 EFX05222.1 - 9.4e-09 35.2 0.1 1.9e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.11 EFX05222.1 - 2.4e-07 30.7 0.0 1.1e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain 14-3-3 PF00244.15 EFX05223.1 - 1.3e-07 30.9 0.0 3e-07 29.7 0.0 1.5 2 0 0 2 2 2 1 14-3-3 protein DUF3493 PF11998.3 EFX05224.1 - 0.57 10.1 2.5 2.6 7.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3493) Amidoligase_2 PF12224.3 EFX05225.1 - 2.2e-22 79.9 0.0 1.5e-17 64.0 0.0 2.0 2 0 0 2 2 2 2 Putative amidoligase enzyme FmrO PF07091.6 EFX05225.1 - 0.098 11.6 0.0 0.21 10.5 0.0 1.5 2 0 0 2 2 2 0 Ribosomal RNA methyltransferase (FmrO) Vma12 PF11712.3 EFX05226.1 - 2.7e-33 114.6 0.0 7.1e-33 113.3 0.0 1.7 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase zf-C2H2_3 PF13878.1 EFX05226.1 - 1.1e-06 28.0 0.1 2.2e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO GILT PF03227.11 EFX05227.1 - 7e-13 48.3 0.1 1.1e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) TLD PF07534.11 EFX05228.1 - 2.9e-27 95.3 0.0 2.7e-26 92.2 0.0 2.1 1 1 0 1 1 1 1 TLD MUG2_C PF08593.5 EFX05228.1 - 2.6e-07 30.7 0.3 6.7e-07 29.4 0.2 1.8 1 0 0 1 1 1 1 Meiotically up-regulated glycoproteins C-terminal Troponin-I_N PF11636.3 EFX05228.1 - 0.14 11.8 4.3 0.39 10.4 3.0 1.7 1 0 0 1 1 1 0 Troponin I residues 1-32 FAA_hydrolase PF01557.13 EFX05229.1 - 4.7e-47 160.2 0.0 7.1e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 EFX05229.1 - 5e-21 74.7 0.0 8.6e-21 73.9 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Ribonuc_L-PSP PF01042.16 EFX05230.1 - 1.8e-34 118.0 0.0 2e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP SIR2 PF02146.12 EFX05231.1 - 1.1e-29 103.4 0.0 2.1e-29 102.4 0.0 1.4 1 1 0 1 1 1 1 Sir2 family zf-C3HC PF07967.8 EFX05234.1 - 9.7e-37 125.7 0.0 3.5e-34 117.4 0.0 2.2 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 EFX05234.1 - 1.3e-24 85.8 1.7 8.3e-24 83.2 0.0 2.5 2 0 0 2 2 2 1 Rsm1-like BIR PF00653.16 EFX05234.1 - 0.00035 20.9 0.1 0.0047 17.3 0.0 2.3 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain PBP1_TM PF14812.1 EFX05234.1 - 0.0074 16.5 0.5 0.023 14.9 0.4 1.8 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Fungal_trans_2 PF11951.3 EFX05235.1 - 3.4e-11 42.3 0.1 5.6e-06 25.1 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05235.1 - 3.3e-05 23.7 11.0 6.1e-05 22.8 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M24 PF00557.19 EFX05237.1 - 3e-37 128.2 0.0 1.6e-36 125.8 0.0 1.9 1 1 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 EFX05237.1 - 8.5e-07 29.5 0.0 1.5e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain PGI PF00342.14 EFX05238.1 - 1.5e-207 689.8 0.2 1.7e-207 689.6 0.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Pkinase PF00069.20 EFX05239.1 - 2e-71 240.1 0.0 2.4e-71 239.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05239.1 - 3.2e-30 105.0 0.0 4.1e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EFX05239.1 - 0.0025 17.5 0.1 0.0058 16.3 0.1 1.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EFX05239.1 - 0.0066 15.3 0.1 0.0097 14.7 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.1 EFX05239.1 - 0.026 13.4 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 EFX05239.1 - 0.2 10.6 0.2 0.84 8.6 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Complex1_LYR_2 PF13233.1 EFX05241.1 - 2.2e-16 60.2 0.0 2.7e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 EFX05241.1 - 0.03 14.1 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Complex 1 protein (LYR family) Xan_ur_permease PF00860.15 EFX05242.1 - 2.6e-61 207.2 35.3 8.3e-61 205.6 24.5 1.7 1 1 0 1 1 1 1 Permease family Nairo_nucleo PF02477.10 EFX05242.1 - 0.16 10.6 0.1 0.28 9.8 0.0 1.3 1 0 0 1 1 1 0 Nucleocapsid N protein Calreticulin PF00262.13 EFX05243.1 - 2e-158 526.8 19.2 2.7e-158 526.4 13.3 1.2 1 0 0 1 1 1 1 Calreticulin family Abhydrolase_6 PF12697.2 EFX05244.1 - 1.8e-13 50.9 0.0 2.3e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX05244.1 - 0.00031 20.5 0.0 0.00044 20.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05244.1 - 0.015 14.8 0.0 4 6.9 0.0 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF676 PF05057.9 EFX05244.1 - 0.022 14.0 0.0 0.78 8.9 0.0 2.3 1 1 2 3 3 3 0 Putative serine esterase (DUF676) PGAP1 PF07819.8 EFX05244.1 - 0.032 13.8 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_8 PF06259.7 EFX05244.1 - 0.067 12.6 0.0 0.74 9.2 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase bZIP_1 PF00170.16 EFX05245.1 - 9.5e-09 35.0 15.2 2.7e-08 33.6 10.5 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX05245.1 - 0.0034 17.1 15.0 0.0034 17.1 10.4 2.7 1 1 1 2 2 2 1 Basic region leucine zipper Atg14 PF10186.4 EFX05245.1 - 0.3 9.9 12.9 0.42 9.5 8.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 EFX05245.1 - 2.4 7.7 8.9 3.5 7.1 6.2 1.3 1 0 0 1 1 1 0 IncA protein Prp19 PF08606.6 EFX05245.1 - 8.4 6.2 9.8 9.8 5.9 1.1 2.5 1 1 1 2 2 2 0 Prp19/Pso4-like Ribosomal_S19 PF00203.16 EFX05246.1 - 2.4e-23 81.5 0.0 3.1e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Cyclin_N PF00134.18 EFX05247.1 - 1.3e-10 40.9 0.2 3.1e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain ABC_membrane PF00664.18 EFX05247.1 - 0.19 11.0 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region APH PF01636.18 EFX05248.1 - 2.3e-18 66.7 0.1 3.1e-18 66.3 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EFX05248.1 - 0.018 14.6 0.5 0.033 13.7 0.3 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Zds_C PF08632.5 EFX05249.1 - 1.5e-30 104.3 0.4 2.5e-30 103.6 0.3 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF2456 PF10445.4 EFX05250.1 - 4.6e-17 61.7 1.5 4.6e-17 61.7 1.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2456) TrkH PF02386.11 EFX05250.1 - 0.091 11.3 1.0 0.17 10.4 0.7 1.3 1 0 0 1 1 1 0 Cation transport protein TGF_beta_GS PF08515.7 EFX05250.1 - 8.1 5.8 8.8 4.9 6.5 2.8 2.3 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif PAT1 PF09770.4 EFX05251.1 - 1.6e-218 727.8 21.8 7.1e-218 725.7 15.1 1.7 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Herpes_HEPA PF03324.9 EFX05251.1 - 0.15 12.1 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus DNA helicase/primase complex associated protein SUR7 PF06687.7 EFX05253.1 - 1.4e-29 103.2 15.9 1.7e-29 102.9 11.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family Sporozoite_P67 PF05642.6 EFX05253.1 - 0.15 9.9 0.8 0.18 9.6 0.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4064 PF13273.1 EFX05253.1 - 2.5 8.2 12.8 6.5 6.9 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) RuBisCO_large_N PF02788.11 EFX05253.1 - 7.5 6.2 7.6 2.4 7.8 3.0 1.8 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain Alpha-L-AF_C PF06964.7 EFX05255.1 - 7.3e-30 104.0 0.0 1.2e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminus Glyco_hydro_44 PF12891.2 EFX05255.1 - 0.21 11.0 2.8 0.36 10.2 0.3 2.0 1 1 1 2 2 2 0 Glycoside hydrolase family 44 MARVEL PF01284.18 EFX05257.1 - 2.1e-10 40.5 2.4 2.5e-10 40.3 1.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF1761 PF08570.5 EFX05257.1 - 0.0081 16.1 0.6 0.011 15.7 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) ATG22 PF11700.3 EFX05257.1 - 0.048 12.1 0.8 0.052 12.0 0.5 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DUF2374 PF09574.5 EFX05257.1 - 0.26 10.9 2.9 7.5 6.2 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (Duf2374) Peptidase_M1 PF01433.15 EFX05258.1 - 1.5e-139 465.4 0.0 2e-139 465.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EFX05258.1 - 5e-93 311.9 0.0 7.2e-93 311.3 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EFX05258.1 - 4.9e-20 71.8 0.2 9.1e-20 70.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily HSP70 PF00012.15 EFX05259.1 - 4.7e-269 893.3 4.6 5.4e-269 893.2 3.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFX05259.1 - 6.7e-17 61.0 0.0 6.7e-16 57.7 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EFX05259.1 - 0.0034 17.0 0.0 0.0071 15.9 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 EFX05259.1 - 0.006 16.4 1.9 0.63 9.8 0.1 3.0 2 2 0 2 2 2 1 Cell division protein FtsA Hydantoinase_A PF01968.13 EFX05259.1 - 0.0098 15.0 0.0 0.038 13.0 0.0 1.9 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase StbA PF06406.6 EFX05259.1 - 0.051 12.5 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 StbA protein DUF4404 PF14357.1 EFX05259.1 - 1.7 9.0 6.3 1.5 9.2 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF1843 PF08898.5 EFX05259.1 - 3.1 7.9 5.8 1.2 9.2 0.5 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) FAA_hydrolase PF01557.13 EFX05260.1 - 5.6e-60 202.4 0.0 6.9e-60 202.2 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family SBP_bac_6 PF13343.1 EFX05260.1 - 0.037 13.3 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein GCV_T PF01571.16 EFX05261.1 - 2.3e-18 66.3 0.0 3.6e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 EFX05261.1 - 0.0025 17.7 0.1 0.0097 15.9 0.0 2.0 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain GMC_oxred_N PF00732.14 EFX05262.1 - 6.7e-59 199.4 0.0 9.1e-59 199.0 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX05262.1 - 2.4e-33 115.4 0.0 5.7e-33 114.2 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EFX05262.1 - 3.6e-06 26.0 0.7 0.02 13.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EFX05262.1 - 0.00038 19.4 0.2 0.00069 18.6 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EFX05262.1 - 0.011 15.7 0.6 0.029 14.4 0.2 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX05262.1 - 0.017 14.0 2.1 0.022 13.6 0.2 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX05262.1 - 0.038 14.0 0.3 4.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX05262.1 - 0.043 13.6 0.2 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX05262.1 - 0.097 11.7 0.2 0.21 10.6 0.1 1.4 1 0 0 1 1 1 0 Thi4 family VWA PF00092.23 EFX05263.1 - 1.1e-06 28.5 0.0 2.8e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 EFX05263.1 - 1.1e-06 28.9 0.0 1.9e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 EFX05263.1 - 0.00015 21.6 0.0 0.00023 21.0 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus HET PF06985.6 EFX05265.1 - 0.0054 16.8 0.1 0.018 15.1 0.0 2.0 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) adh_short PF00106.20 EFX05266.1 - 2.9e-19 69.6 1.3 3.2e-19 69.4 0.3 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX05266.1 - 2.2e-13 50.5 0.4 2.8e-13 50.2 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.5 EFX05266.1 - 0.031 13.4 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GspH PF12019.3 EFX05267.1 - 0.17 12.0 2.3 0.19 11.8 1.6 1.1 1 0 0 1 1 1 0 Type II transport protein GspH Dynamin_N PF00350.18 EFX05269.1 - 1.8e-21 76.6 0.1 1.5e-20 73.7 0.0 2.1 1 1 0 1 1 1 1 Dynamin family Miro PF08477.8 EFX05269.1 - 0.00049 20.5 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Dynamin_M PF01031.15 EFX05269.1 - 0.0023 16.7 0.0 0.0074 15.0 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region AAA_29 PF13555.1 EFX05269.1 - 0.037 13.5 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 EFX05269.1 - 0.058 13.3 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 EFX05269.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.11 EFX05270.1 - 5.4e-48 163.4 40.2 5.4e-48 163.4 27.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05270.1 - 8.9e-09 34.4 26.2 4.2e-08 32.2 18.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.15 EFX05270.1 - 0.00057 18.0 1.4 0.00057 18.0 1.0 2.6 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.8 EFX05270.1 - 0.0012 17.0 1.1 0.0019 16.3 0.8 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector DIE2_ALG10 PF04922.7 EFX05271.1 - 4.6e-69 233.2 28.7 2.2e-46 158.6 9.1 4.9 3 1 0 3 3 3 3 DIE2/ALG10 family MARVEL PF01284.18 EFX05273.1 - 0.00015 21.6 20.5 0.0013 18.5 13.8 2.2 1 1 1 2 2 2 1 Membrane-associating domain Peptidase_M56 PF05569.6 EFX05273.1 - 0.046 12.6 0.3 0.068 12.1 0.2 1.3 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF588 PF04535.7 EFX05273.1 - 0.1 12.1 8.9 0.058 12.9 4.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF588) EBP PF05241.7 EFX05275.1 - 4.6e-69 231.3 7.0 5.6e-69 231.0 4.8 1.0 1 0 0 1 1 1 1 Emopamil binding protein zf-H2C2_2 PF13465.1 EFX05276.1 - 5.4e-05 23.2 7.3 0.0053 16.9 0.7 2.9 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFX05276.1 - 0.0021 18.2 10.6 0.081 13.3 0.3 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFX05276.1 - 0.0038 17.3 4.8 0.033 14.3 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EFX05276.1 - 0.0098 16.1 13.8 0.2 12.0 1.1 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EFX05276.1 - 0.037 13.9 0.8 0.037 13.9 0.5 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.11 EFX05277.1 - 7.1e-29 100.6 35.9 3.7e-24 85.0 7.4 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05277.1 - 5.5e-08 31.8 7.0 5.5e-08 31.8 4.8 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter bZIP_2 PF07716.10 EFX05278.1 - 1.8e-12 46.8 12.2 3.1e-12 46.1 8.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EFX05278.1 - 6.8e-06 25.9 8.6 1.4e-05 24.9 5.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor XhlA PF10779.4 EFX05278.1 - 0.004 17.0 4.8 0.009 15.9 3.3 1.6 1 1 0 1 1 1 1 Haemolysin XhlA bZIP_Maf PF03131.12 EFX05278.1 - 0.011 16.0 6.6 0.021 15.1 4.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor TSC22 PF01166.13 EFX05278.1 - 0.041 13.8 0.2 0.089 12.7 0.2 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF4094 PF13334.1 EFX05278.1 - 0.34 11.3 2.8 0.69 10.3 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) LMBR1 PF04791.11 EFX05278.1 - 1.4 7.4 3.6 1.9 6.9 2.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF972 PF06156.8 EFX05278.1 - 3.7 7.9 7.1 2.8 8.3 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) PhyH PF05721.8 EFX05279.1 - 1.6e-11 44.6 0.0 2.3e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.7 EFX05279.1 - 7.6e-07 27.9 0.0 0.04 12.4 0.0 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF1479) tRNA-synt_1d PF00750.14 EFX05280.1 - 5e-24 84.7 0.0 6.5e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DUF676 PF05057.9 EFX05281.1 - 6e-43 146.6 0.0 1.3e-28 99.7 0.0 3.1 2 1 0 2 2 2 2 Putative serine esterase (DUF676) Gly_transf_sug PF04488.10 EFX05282.1 - 3.8e-09 36.8 0.0 8.9e-09 35.6 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 EFX05282.1 - 0.063 12.4 0.0 0.094 11.8 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Peptidase_M20 PF01546.23 EFX05283.1 - 2.8e-23 82.4 0.0 4.5e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.27 EFX05283.1 - 8.3e-17 60.3 5.5 0.00036 20.3 0.0 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat M20_dimer PF07687.9 EFX05283.1 - 0.00059 19.5 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFX05283.1 - 0.0029 17.3 0.0 0.0058 16.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Pet127 PF08634.5 EFX05283.1 - 0.11 11.5 0.1 0.24 10.5 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial protein Pet127 Peptidase_M42 PF05343.9 EFX05283.1 - 0.12 11.0 0.0 0.26 9.9 0.0 1.5 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase PQQ_3 PF13570.1 EFX05283.1 - 0.89 9.9 6.3 5.6 7.3 0.0 4.4 4 0 0 4 4 4 0 PQQ-like domain Beta_elim_lyase PF01212.16 EFX05284.1 - 4.9e-65 219.5 0.0 9.1e-65 218.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EFX05284.1 - 2.5e-06 26.7 0.0 4.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFX05284.1 - 0.018 13.3 0.0 0.036 12.3 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme bZIP_1 PF00170.16 EFX05284.1 - 0.19 11.7 7.2 0.38 10.7 5.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor MFS_1 PF07690.11 EFX05285.1 - 2.6e-14 52.6 18.1 5.9e-14 51.5 12.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.13 EFX05285.1 - 4.2e-08 32.9 4.2 6.6e-08 32.3 2.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2104 PF09877.4 EFX05285.1 - 0.055 13.4 3.7 0.23 11.4 0.2 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2104) Pkinase PF00069.20 EFX05286.1 - 7.7e-70 234.9 0.0 9.8e-70 234.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05286.1 - 2.7e-32 111.8 0.0 3.6e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EFX05286.1 - 1.2e-09 38.4 2.5 3.6e-09 36.9 1.8 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFX05286.1 - 0.0018 17.2 0.0 0.0029 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HAUS6_N PF14661.1 EFX05287.1 - 2.3e-55 187.6 0.3 2.3e-55 187.6 0.2 2.5 4 0 0 4 4 4 1 HAUS augmin-like complex subunit 6 N-terminus Abhydrolase_5 PF12695.2 EFX05288.1 - 5.1e-15 55.4 0.3 9.2e-15 54.6 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX05288.1 - 1.7e-13 50.9 6.6 3.3e-13 50.0 4.6 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05288.1 - 4.5e-11 42.7 0.1 6.2e-11 42.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 EFX05288.1 - 0.00064 19.3 0.6 0.001 18.6 0.4 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.7 EFX05288.1 - 0.00069 18.5 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.3 EFX05288.1 - 0.0022 17.8 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_2 PF02230.11 EFX05288.1 - 0.0056 16.1 0.1 0.31 10.4 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase PGAP1 PF07819.8 EFX05288.1 - 0.032 13.8 0.4 0.16 11.5 0.3 1.9 1 1 0 1 1 1 0 PGAP1-like protein Ser_hydrolase PF06821.8 EFX05288.1 - 0.073 12.6 0.4 0.14 11.7 0.3 1.4 1 0 0 1 1 1 0 Serine hydrolase DLH PF01738.13 EFX05288.1 - 0.073 12.3 0.0 0.18 11.0 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family AXE1 PF05448.7 EFX05288.1 - 0.13 10.7 0.1 0.36 9.2 0.1 1.6 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) FSH1 PF03959.8 EFX05288.1 - 0.14 11.5 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF1749 PF08538.5 EFX05288.1 - 0.14 11.0 0.0 0.27 10.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DUF2305 PF10230.4 EFX05288.1 - 0.18 11.1 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Mg_trans_NIPA PF05653.9 EFX05289.1 - 3.5e-92 308.5 25.2 5e-92 308.0 17.5 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 EFX05289.1 - 5.2e-08 33.0 3.1 5.2e-08 33.0 2.2 2.7 2 1 0 2 2 2 1 Multidrug resistance efflux transporter EamA PF00892.15 EFX05289.1 - 8.4e-06 25.8 6.6 8.4e-06 25.8 4.6 3.2 3 0 0 3 3 3 1 EamA-like transporter family DUF914 PF06027.7 EFX05289.1 - 0.0011 17.8 1.5 0.0011 17.8 1.0 2.2 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) 2-Hacid_dh_C PF02826.14 EFX05291.1 - 7.7e-42 142.4 0.0 9.9e-42 142.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX05291.1 - 2.2e-09 36.9 0.0 2.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFX05291.1 - 0.0034 17.2 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF3640 PF12342.3 EFX05291.1 - 0.016 14.7 0.4 0.4 10.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3640) MFS_1 PF07690.11 EFX05292.1 - 2.1e-21 76.0 51.4 2.2e-19 69.4 18.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Mucin PF01456.12 EFX05293.1 - 0.00025 20.8 18.2 0.00025 20.8 12.6 2.4 1 1 1 2 2 2 1 Mucin-like glycoprotein CFEM PF05730.6 EFX05293.1 - 0.00064 19.4 8.5 0.0019 18.0 5.9 1.8 1 0 0 1 1 1 1 CFEM domain DUF4551 PF15087.1 EFX05293.1 - 0.028 12.7 5.7 0.035 12.4 3.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Daxx PF03344.10 EFX05293.1 - 1.9 6.8 18.0 2.5 6.4 12.5 1.1 1 0 0 1 1 1 0 Daxx Family Hamartin PF04388.7 EFX05293.1 - 6.4 5.3 20.5 7.8 5.0 14.2 1.2 1 0 0 1 1 1 0 Hamartin protein Securin PF04856.8 EFX05294.1 - 0.037 13.7 0.0 0.27 10.9 0.0 2.2 2 1 0 2 2 2 0 Securin sister-chromatid separation inhibitor Pribosyltran PF00156.22 EFX05296.1 - 1.3e-15 57.1 1.2 2.2e-15 56.4 0.8 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EFX05296.1 - 0.021 14.0 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Ribosomal_L18e PF00828.14 EFX05296.1 - 0.31 11.4 1.6 0.49 10.7 1.1 1.5 1 1 0 1 1 1 0 Ribosomal protein L18e/L15 COX15-CtaA PF02628.10 EFX05297.1 - 4.1e-93 311.5 16.6 5.3e-93 311.2 11.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein ELFV_dehydrog PF00208.16 EFX05298.1 - 1.8e-84 283.1 5.3 2.3e-84 282.8 3.7 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 EFX05298.1 - 1.5e-48 163.6 0.0 2.9e-48 162.7 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.1 EFX05298.1 - 0.0003 21.0 0.9 0.00072 19.7 0.6 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.1 EFX05298.1 - 0.023 14.7 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 EFX05298.1 - 0.058 12.9 0.2 0.094 12.2 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CFEM PF05730.6 EFX05299.1 - 3.2e-12 46.0 7.9 5.5e-12 45.3 5.5 1.4 1 0 0 1 1 1 1 CFEM domain NSP2-B_epitope PF14757.1 EFX05300.1 - 0.16 11.4 1.9 0.24 10.8 1.3 1.2 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein ATG22 PF11700.3 EFX05301.1 - 2.7e-105 352.5 20.3 3.1e-105 352.4 14.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like DUF1616 PF07760.6 EFX05301.1 - 0.24 10.4 4.0 0.33 10.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) S-AdoMet_synt_N PF00438.15 EFX05301.1 - 0.49 10.6 1.7 1 9.6 0.0 2.3 3 0 0 3 3 3 0 S-adenosylmethionine synthetase, N-terminal domain ATPase_gene1 PF09527.5 EFX05301.1 - 7.2 6.4 18.3 1.5 8.6 5.1 4.2 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit (ATPase_gene1) APC10 PF03256.11 EFX05303.1 - 9.5e-48 162.3 0.0 1.3e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Ada3 PF10198.4 EFX05304.1 - 3e-44 149.9 0.0 1.9e-43 147.3 0.0 2.2 3 0 0 3 3 3 1 Histone acetyltransferases subunit 3 Methyltransf_23 PF13489.1 EFX05306.1 - 2.9e-20 72.6 0.0 5.3e-20 71.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05306.1 - 8.3e-09 35.8 0.0 1.4e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05306.1 - 2.5e-07 30.3 0.0 1.1e-06 28.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05306.1 - 3.1e-07 30.9 0.0 4.5e-06 27.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05306.1 - 1.2e-06 28.9 0.0 4.4e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05306.1 - 0.00067 19.9 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX05306.1 - 0.0045 16.0 0.0 0.0085 15.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 EFX05306.1 - 0.012 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 EFX05306.1 - 0.057 12.4 0.0 0.083 11.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 EFX05306.1 - 0.062 12.3 0.0 0.26 10.3 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 EFX05306.1 - 0.076 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 EFX05306.1 - 0.2 10.7 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 EFX05306.1 - 0.21 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase TPR_16 PF13432.1 EFX05308.1 - 0.21 12.3 1.9 0.67 10.7 1.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Osteopontin PF00865.13 EFX05308.1 - 5.3 6.1 15.0 7.6 5.6 10.4 1.2 1 0 0 1 1 1 0 Osteopontin Glyco_trans_1_4 PF13692.1 EFX05309.1 - 2.8e-24 85.8 0.4 1.7e-21 76.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EFX05309.1 - 1.6e-05 25.1 10.5 1.8e-05 24.9 6.2 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.15 EFX05309.1 - 0.00012 21.5 0.0 0.00037 19.9 0.0 1.7 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EFX05309.1 - 0.0041 17.3 0.0 0.008 16.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF347 PF03988.7 EFX05309.1 - 0.068 13.0 0.6 0.18 11.7 0.4 1.7 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Mito_carr PF00153.22 EFX05310.1 - 2.8e-29 100.6 0.2 2e-15 56.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Rad51 PF08423.6 EFX05311.1 - 0.012 14.5 0.0 0.098 11.5 0.0 2.0 2 0 0 2 2 2 0 Rad51 AAA_25 PF13481.1 EFX05311.1 - 0.1 12.0 0.6 0.81 9.0 0.4 2.2 1 1 0 1 1 1 0 AAA domain ATP-synt_Eps PF04627.8 EFX05312.1 - 2.5e-24 84.5 0.9 3e-24 84.3 0.6 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain RCR PF12273.3 EFX05313.1 - 2.6e-21 76.5 3.2 3.4e-21 76.1 2.2 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF4131 PF13567.1 EFX05313.1 - 0.0091 15.4 0.3 0.011 15.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) BatD PF13584.1 EFX05313.1 - 0.033 12.7 0.0 0.041 12.4 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance LA-virus_coat PF09220.5 EFX05313.1 - 0.059 11.8 0.2 0.08 11.3 0.2 1.1 1 0 0 1 1 1 0 L-A virus, major coat protein YwiC PF14256.1 EFX05313.1 - 0.079 13.0 0.9 0.1 12.6 0.6 1.1 1 0 0 1 1 1 0 YwiC-like protein PDR_CDR PF06422.7 EFX05313.1 - 0.14 11.8 0.2 0.21 11.2 0.2 1.3 1 0 0 1 1 1 0 CDR ABC transporter She9_MDM33 PF05546.6 EFX05313.1 - 0.83 9.1 3.3 0.47 9.9 1.0 1.4 2 0 0 2 2 2 0 She9 / Mdm33 family Amidohydro_1 PF01979.15 EFX05314.1 - 2.9e-40 138.9 0.3 5e-40 138.1 0.0 1.5 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_4 PF13147.1 EFX05314.1 - 3.3e-08 33.9 0.6 1e-06 29.0 0.0 2.7 2 1 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 EFX05314.1 - 1.3e-07 31.1 6.8 1.5e-05 24.4 0.1 3.6 3 2 1 4 4 4 2 Amidohydrolase family Amidohydro_5 PF13594.1 EFX05314.1 - 1e-05 25.2 0.7 0.00034 20.3 0.0 2.7 2 1 0 2 2 2 1 Amidohydrolase DAD PF02109.11 EFX05315.1 - 2.2e-49 166.2 2.5 3.2e-49 165.6 1.7 1.2 1 0 0 1 1 1 1 DAD family Pex14_N PF04695.8 EFX05315.1 - 0.0048 16.9 3.6 0.009 16.0 2.5 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1180 PF06679.7 EFX05315.1 - 0.16 11.8 4.5 0.22 11.3 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Med3 PF11593.3 EFX05315.1 - 0.21 10.7 10.7 0.19 10.9 7.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Enolase_C PF00113.17 EFX05316.1 - 2.3e-150 499.5 0.0 2.9e-150 499.2 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 EFX05316.1 - 1.2e-57 193.5 0.2 2.1e-57 192.7 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE PF01188.16 EFX05316.1 - 0.012 16.1 0.0 0.036 14.6 0.0 1.9 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MAAL_C PF07476.6 EFX05316.1 - 0.017 14.0 0.3 0.28 10.0 0.1 2.5 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase C-terminus MR_MLE_C PF13378.1 EFX05316.1 - 0.048 13.6 0.0 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 Enolase C-terminal domain-like Fungal_trans_2 PF11951.3 EFX05317.1 - 4.8e-51 173.5 0.1 7e-51 173.0 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05317.1 - 4.2e-08 32.9 8.4 7.4e-08 32.1 5.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pmp3 PF01679.12 EFX05318.1 - 6.6e-12 44.9 3.1 1e-11 44.3 2.2 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator HCV_capsid PF01543.12 EFX05318.1 - 0.043 13.8 1.0 0.076 13.0 0.7 1.4 1 0 0 1 1 1 0 Hepatitis C virus capsid protein Levi_coat PF01819.12 EFX05318.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Levivirus coat protein p450 PF00067.17 EFX05320.1 - 2.3e-60 204.4 0.0 3e-60 204.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cyclin_N PF00134.18 EFX05322.1 - 1.6e-13 50.3 0.3 3.2e-13 49.3 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.6 EFX05322.1 - 3.6e-11 43.6 1.2 4.9e-11 43.2 0.1 1.8 2 1 0 2 2 2 1 Cyclin Mannitol_dh_C PF08125.8 EFX05323.1 - 4.6e-45 153.7 0.1 6.5e-45 153.2 0.1 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.18 EFX05323.1 - 4.9e-20 72.0 0.4 3.6e-19 69.1 0.1 2.1 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.9 EFX05323.1 - 3.2e-05 23.3 1.8 0.00083 18.7 0.1 2.5 2 1 1 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DicB PF05358.6 EFX05323.1 - 0.093 12.2 0.1 0.79 9.2 0.1 2.2 2 0 0 2 2 2 0 DicB protein SH3_1 PF00018.23 EFX05324.1 - 1.1e-27 95.0 0.0 8.2e-14 50.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 EFX05324.1 - 3e-18 65.1 0.1 3.8e-08 32.7 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.19 EFX05324.1 - 1.9e-13 50.1 0.0 3.5e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.12 EFX05324.1 - 1.8e-12 46.5 0.0 1.3e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.19 EFX05324.1 - 1.3e-09 37.5 0.4 2.2e-09 36.8 0.3 1.3 1 0 0 1 1 1 1 PB1 domain Rad60-SLD PF11976.3 EFX05324.1 - 0.018 14.7 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Oxidored_FMN PF00724.15 EFX05325.1 - 1.5e-41 142.5 0.0 2e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family p450 PF00067.17 EFX05326.1 - 2.2e-49 168.2 0.0 7.1e-41 140.2 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Acyl_transf_1 PF00698.16 EFX05327.1 - 1.6e-80 270.8 0.0 1.1e-78 264.7 0.0 3.1 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.14 EFX05327.1 - 1e-38 131.4 0.0 2.2e-38 130.3 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain DUF1729 PF08354.5 EFX05327.1 - 4.2e-30 103.3 0.1 1e-29 102.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 EFX05327.1 - 1.5e-21 76.6 0.1 5.5e-21 74.7 0.0 2.1 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase NMO PF03060.10 EFX05327.1 - 0.00079 18.6 0.1 0.62 9.1 0.0 2.4 2 0 0 2 2 2 2 Nitronate monooxygenase Cellulase PF00150.13 EFX05328.1 - 9.8e-53 179.1 5.1 1.2e-52 178.8 3.6 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Dopey_N PF04118.9 EFX05330.1 - 7.8e-116 386.1 0.0 2.2e-115 384.6 0.0 1.7 2 0 0 2 2 2 1 Dopey, N-terminal Sel1 PF08238.7 EFX05332.1 - 9e-13 48.4 11.4 0.0028 18.2 0.0 4.4 4 0 0 4 4 4 3 Sel1 repeat Tannase PF07519.6 EFX05333.1 - 9.1e-92 308.2 0.6 1.1e-91 308.0 0.4 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_5 PF12695.2 EFX05333.1 - 6.1e-06 26.0 0.0 3.1e-05 23.7 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX05333.1 - 0.00028 20.8 0.0 0.00086 19.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX05333.1 - 0.0026 17.0 0.1 0.052 12.7 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 EFX05333.1 - 0.01 15.4 0.0 0.017 14.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Patched PF02460.13 EFX05334.1 - 4.4e-68 229.9 13.6 3.9e-46 157.4 0.2 2.2 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.3 EFX05334.1 - 8.2e-49 164.9 6.6 8.2e-49 164.9 4.6 2.9 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 EFX05334.1 - 0.00025 19.8 8.3 0.00025 19.8 5.7 2.8 2 1 0 2 2 2 1 MMPL family Folate_rec PF03024.9 EFX05334.1 - 0.0033 17.0 1.3 0.0033 17.0 0.9 1.6 2 0 0 2 2 2 1 Folate receptor family ACR_tran PF00873.14 EFX05334.1 - 0.32 8.3 18.1 0.0071 13.8 7.2 1.8 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family PI-PLC-X PF00388.14 EFX05335.1 - 1.2e-09 37.6 0.0 1.8e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 Phosphatidylinositol-specific phospholipase C, X domain WD40 PF00400.27 EFX05336.1 - 4e-24 83.5 9.4 1.6e-08 34.0 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat Zn_Tnp_IS1595 PF12760.2 EFX05336.1 - 0.0047 16.6 2.7 0.0092 15.7 1.8 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Aminotran_1_2 PF00155.16 EFX05337.1 - 2.7e-61 207.5 0.0 3.1e-61 207.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EFX05337.1 - 0.017 13.4 0.1 0.053 11.7 0.0 1.9 2 1 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Tyrosinase PF00264.15 EFX05338.1 - 1.3e-21 77.7 1.5 1.4e-21 77.7 0.2 1.7 2 0 0 2 2 2 1 Common central domain of tyrosinase Myb_DNA-bind_6 PF13921.1 EFX05338.1 - 0.052 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Peptidase_C13 PF01650.13 EFX05339.1 - 5.6e-39 133.9 0.1 9.3e-39 133.2 0.1 1.3 1 0 0 1 1 1 1 Peptidase C13 family TFIIIC_delta PF12657.2 EFX05339.1 - 6e-17 61.8 0.0 8.8e-09 35.3 0.0 2.9 3 0 0 3 3 3 2 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.2 EFX05339.1 - 1.2e-12 47.6 0.4 1.2e-12 47.6 0.3 1.8 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex TatD_DNase PF01026.16 EFX05340.1 - 1.6e-45 155.2 0.5 2.4e-44 151.4 0.3 2.1 1 1 0 1 1 1 1 TatD related DNase Peptidase_C50 PF03568.12 EFX05341.1 - 1.4e-102 343.2 0.0 2.1e-102 342.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C50 Amidohydro_2 PF04909.9 EFX05342.1 - 7e-26 91.3 0.0 8.2e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Peptidase_M20 PF01546.23 EFX05343.1 - 5.8e-22 78.1 0.0 1.1e-21 77.2 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX05343.1 - 1.4e-13 50.5 0.0 2.9e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EFX05343.1 - 0.0059 16.3 0.1 0.016 14.9 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M28 VWA_3 PF13768.1 EFX05343.1 - 0.085 12.5 0.0 0.63 9.7 0.0 2.4 2 0 0 2 2 2 0 von Willebrand factor type A domain Cu-oxidase_3 PF07732.10 EFX05344.1 - 1.5e-38 131.1 1.7 1.1e-37 128.3 0.1 2.7 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EFX05344.1 - 4.3e-33 113.7 2.2 1.8e-29 101.9 0.1 3.0 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.17 EFX05344.1 - 1.1e-24 87.1 0.0 2.2e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Multicopper oxidase DUF3328 PF11807.3 EFX05344.1 - 0.037 13.7 0.1 0.061 12.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) SnoaL_4 PF13577.1 EFX05345.1 - 4.3e-20 71.9 0.0 4.9e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain Ring_hydroxyl_B PF00866.13 EFX05345.1 - 0.1 12.2 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating beta subunit Pro-kuma_activ PF09286.6 EFX05346.1 - 3.6e-26 91.9 0.6 1.6e-25 89.7 0.3 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Acetyltransf_1 PF00583.19 EFX05347.1 - 2.3e-09 37.1 0.0 3.4e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX05347.1 - 1.1e-07 31.8 0.0 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFX05347.1 - 0.0024 17.9 0.0 0.0036 17.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX05347.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.1 EFX05347.1 - 0.051 13.4 0.0 0.19 11.5 0.0 1.9 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain tRNA-synt_2b PF00587.20 EFX05348.1 - 6.6e-17 61.6 0.0 6.3e-16 58.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EFX05348.1 - 2.5e-08 33.8 0.5 1.1e-07 31.8 0.3 1.9 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain tRNA-synt_His PF13393.1 EFX05348.1 - 0.062 12.3 0.1 0.24 10.4 0.0 2.0 2 0 0 2 2 2 0 Histidyl-tRNA synthetase Ribosomal_60s PF00428.14 EFX05349.1 - 3 8.3 6.2 4.8 7.6 0.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cmc1 PF08583.5 EFX05350.1 - 4.9e-17 61.4 0.8 5.7e-17 61.2 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like FliG_N PF14842.1 EFX05350.1 - 0.024 14.7 0.0 0.029 14.4 0.0 1.1 1 0 0 1 1 1 0 FliG N-terminal domain NDUF_B7 PF05676.8 EFX05350.1 - 0.05 13.0 0.1 0.067 12.6 0.1 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Hydrolase_6 PF13344.1 EFX05350.1 - 0.13 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase GCK PF07802.6 EFX05350.1 - 0.91 9.6 3.8 4.2 7.5 2.7 1.9 1 1 0 1 1 1 0 GCK domain 4HBT_3 PF13622.1 EFX05351.1 - 1.2e-31 110.4 1.2 1.5e-31 110.1 0.8 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Rhomboid PF01694.17 EFX05354.1 - 1.7e-34 118.9 9.5 1.7e-34 118.9 6.6 2.3 2 0 0 2 2 2 1 Rhomboid family VKOR PF07884.9 EFX05354.1 - 0.011 15.5 0.7 0.011 15.5 0.5 2.3 2 0 0 2 2 2 0 Vitamin K epoxide reductase family PIG-P PF08510.7 EFX05354.1 - 0.074 12.6 2.9 3.8 7.1 0.0 3.5 3 0 0 3 3 3 0 PIG-P DUF1129 PF06570.6 EFX05354.1 - 0.41 9.9 4.3 5 6.3 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) SH3_9 PF14604.1 EFX05355.1 - 5e-11 42.0 0.1 2e-10 40.1 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 EFX05355.1 - 1.1e-10 40.6 0.1 2.4e-10 39.6 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EFX05355.1 - 1.8e-07 30.5 0.0 3.9e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NMT_C PF02799.10 EFX05356.1 - 9.3e-77 256.7 0.0 1.4e-76 256.1 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.14 EFX05356.1 - 2.6e-68 228.7 0.0 4.1e-68 228.0 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.1 EFX05356.1 - 0.0016 18.2 0.1 0.0091 15.8 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF2823 PF11034.3 EFX05357.1 - 1.7e-28 98.5 12.0 1.9e-28 98.3 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2823) Mannosyl_trans3 PF11051.3 EFX05358.1 - 9.2e-66 221.9 0.0 2.7e-65 220.4 0.0 1.6 1 1 0 1 1 1 1 Mannosyltransferase putative MFS_1 PF07690.11 EFX05359.1 - 2e-47 161.6 34.6 2e-47 161.6 24.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05359.1 - 2.7e-13 49.3 2.1 2.7e-13 49.3 1.5 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EFX05359.1 - 6e-05 21.4 6.9 8.4e-05 20.9 1.3 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) WLM PF08325.5 EFX05360.1 - 5.1e-47 160.1 0.1 5.1e-47 160.1 0.1 3.1 4 0 0 4 4 4 1 WLM domain Kelch_3 PF13415.1 EFX05360.1 - 1.7e-27 94.9 11.1 2.5e-09 37.0 0.1 5.9 5 0 0 5 5 5 4 Galactose oxidase, central domain DUF4110 PF13422.1 EFX05360.1 - 3e-26 91.1 0.0 3e-26 91.1 0.0 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.1 EFX05360.1 - 3.5e-15 55.5 27.8 7.7e-06 25.5 0.0 6.6 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.1 EFX05360.1 - 1.5e-14 53.5 12.3 3.5e-07 30.0 0.1 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 EFX05360.1 - 9.8e-14 50.8 4.1 0.0063 16.6 0.1 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 EFX05360.1 - 3.4e-13 48.7 4.7 0.0071 16.0 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 EFX05360.1 - 3.6e-08 32.8 1.2 8.3e-05 22.0 0.1 4.7 5 0 0 5 5 5 1 Kelch motif DUF45 PF01863.12 EFX05360.1 - 5.6e-06 26.2 0.7 5.6e-06 26.2 0.5 2.3 2 0 0 2 2 2 1 Protein of unknown function DUF45 ADH_zinc_N PF00107.21 EFX05362.1 - 7.7e-21 73.9 0.0 1.3e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX05362.1 - 3.1e-06 28.0 0.0 8.6e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 EFX05362.1 - 0.0019 18.7 0.0 0.0039 17.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NAD_kinase PF01513.16 EFX05363.1 - 1.6e-61 207.5 0.0 2.5e-61 206.9 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Clr5 PF14420.1 EFX05364.1 - 2.3e-18 65.7 0.3 4.9e-18 64.7 0.2 1.6 1 0 0 1 1 1 1 Clr5 domain CAP59_mtransfer PF11735.3 EFX05365.1 - 3.3e-48 164.0 0.0 5.1e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DEAD PF00270.24 EFX05366.1 - 1.7e-39 135.0 0.0 5.3e-39 133.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX05366.1 - 8.4e-24 83.2 0.0 2.2e-23 81.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFX05366.1 - 0.00017 20.4 0.0 0.00028 19.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain GAGA_bind PF06217.7 EFX05366.1 - 0.011 15.7 6.1 0.1 12.5 2.8 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family Nuf2 PF03800.9 EFX05368.1 - 1.8e-35 122.1 0.0 6.4e-35 120.2 0.0 1.9 2 0 0 2 2 2 1 Nuf2 family Reo_sigmaC PF04582.7 EFX05368.1 - 2.2 7.3 5.8 2.5 7.2 0.3 2.3 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.6 EFX05368.1 - 6.7 5.2 27.0 0.64 8.6 3.4 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Peptidase_M16 PF00675.15 EFX05369.1 - 2.7e-17 62.9 0.2 5.2e-17 61.9 0.1 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EFX05369.1 - 4.4e-15 55.8 0.0 9.6e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain MAD PF05557.8 EFX05370.1 - 1.5e-48 165.5 43.0 4.4e-47 160.6 29.8 2.1 1 1 0 1 1 1 1 Mitotic checkpoint protein Gp-FAR-1 PF05823.7 EFX05370.1 - 0.011 15.6 4.9 0.012 15.6 1.5 2.6 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) TFIID_30kDa PF03540.8 EFX05372.1 - 7.6e-26 89.7 0.3 1.1e-25 89.1 0.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.1 EFX05372.1 - 0.037 14.4 0.4 0.088 13.2 0.3 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Ras PF00071.17 EFX05373.1 - 6.1e-66 220.7 0.5 7.1e-66 220.5 0.4 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX05373.1 - 1.2e-21 77.4 0.0 1.7e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX05373.1 - 2.7e-16 59.3 0.1 3.2e-16 59.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFX05373.1 - 2e-05 23.8 0.1 2.6e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EFX05373.1 - 4e-05 23.1 0.2 8.2e-05 22.1 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EFX05373.1 - 7e-05 22.7 0.0 0.00013 21.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 EFX05373.1 - 0.0003 20.0 0.0 0.00038 19.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 EFX05373.1 - 0.0013 18.0 0.1 0.0084 15.3 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.1 EFX05373.1 - 0.0013 18.8 0.0 0.0031 17.6 0.0 1.6 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 EFX05373.1 - 0.0015 18.6 0.1 0.12 12.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 EFX05373.1 - 0.0062 15.7 0.0 0.02 14.0 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 EFX05373.1 - 0.023 14.6 0.1 0.084 12.8 0.0 1.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 EFX05373.1 - 0.025 14.5 0.2 0.071 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EFX05373.1 - 0.039 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 EFX05373.1 - 0.058 13.1 0.0 0.096 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.13 EFX05373.1 - 0.063 12.2 0.2 0.2 10.6 0.0 1.9 3 0 0 3 3 3 0 Septin ABC_tran PF00005.22 EFX05373.1 - 0.086 13.1 0.1 0.14 12.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.4 EFX05373.1 - 0.1 12.1 0.1 0.9 9.0 0.0 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Glyco_hydro_72 PF03198.9 EFX05374.1 - 1.1e-111 372.8 0.0 1.3e-111 372.5 0.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 EFX05374.1 - 1.9e-05 23.9 0.0 0.14 11.3 0.0 2.2 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 EFX05374.1 - 0.085 11.7 0.0 0.18 10.6 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Pkinase PF00069.20 EFX05375.1 - 2.6e-29 102.1 0.0 3.5e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05375.1 - 8.2e-11 41.4 0.0 1.2e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-binding PF00249.26 EFX05377.1 - 9.6e-15 54.3 0.1 2.6e-08 33.7 0.0 3.1 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX05377.1 - 2.6e-13 49.8 0.2 5.4e-09 36.0 0.0 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain ISG65-75 PF11727.3 EFX05377.1 - 0.04 12.9 0.9 0.063 12.3 0.6 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DIOX_N PF14226.1 EFX05378.1 - 9.6e-33 113.1 0.0 2.2e-32 112.0 0.0 1.6 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX05378.1 - 1.3e-12 47.9 0.0 2.2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_47 PF01532.15 EFX05379.1 - 1.6e-150 501.6 0.0 6.5e-149 496.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Sld5 PF05916.6 EFX05379.1 - 8.7e-18 64.5 0.0 1.8e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 GINS complex protein CLU PF13236.1 EFX05380.1 - 1.2e-80 270.1 0.0 2.1e-80 269.2 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 EFX05380.1 - 1.9e-45 154.8 0.0 4.3e-45 153.6 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 EFX05380.1 - 5e-25 87.4 0.4 5e-25 87.4 0.3 2.0 2 0 0 2 2 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 EFX05380.1 - 2.5e-20 72.2 9.7 1.4e-09 37.6 0.3 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 EFX05380.1 - 1.8e-15 56.2 4.2 1.7e-05 24.5 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFX05380.1 - 0.00029 20.4 9.3 0.054 13.1 0.4 3.4 1 1 3 4 4 4 4 TPR repeat TPR_2 PF07719.12 EFX05380.1 - 0.011 15.5 0.3 0.011 15.5 0.2 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF727 PF05303.7 EFX05380.1 - 0.028 14.2 0.0 0.36 10.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF727) TPR_17 PF13431.1 EFX05380.1 - 0.034 14.3 0.8 17 5.9 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFX05380.1 - 0.063 13.9 5.4 0.51 11.0 0.0 3.7 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX05380.1 - 0.1 13.1 5.2 0.95 10.0 0.3 3.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.9 EFX05380.1 - 0.26 11.8 5.3 13 6.6 0.1 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFX05380.1 - 0.37 10.4 4.3 0.15 11.6 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFX05380.1 - 0.6 10.0 4.1 0.42 10.5 0.3 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4526 PF15029.1 EFX05381.1 - 0.00031 20.3 0.1 0.00044 19.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4526) DSPc PF00782.15 EFX05383.1 - 8.6e-12 44.7 0.0 2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFX05383.1 - 8.4e-06 25.2 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 EFX05383.1 - 0.017 15.3 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.1 EFX05383.1 - 0.047 13.7 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.7 EFX05383.1 - 0.15 11.5 0.0 0.41 10.0 0.0 1.7 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Glyco_hydro_2 PF00703.16 EFX05384.1 - 2.9e-10 40.5 0.1 7.4e-10 39.2 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.13 EFX05384.1 - 5.3e-10 39.1 0.0 1.1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 EFX05384.1 - 0.00088 18.2 0.0 0.0016 17.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Pkinase PF00069.20 EFX05385.1 - 1.9e-64 217.3 0.0 3.1e-64 216.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05385.1 - 1.2e-33 116.3 0.0 2.6e-33 115.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.14 EFX05385.1 - 4.7e-18 64.3 0.0 7.8e-18 63.6 0.0 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.9 EFX05385.1 - 2e-05 23.7 0.0 4.2e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EFX05385.1 - 0.00067 18.7 0.0 0.0013 17.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 EFX05385.1 - 0.0045 16.2 0.1 0.0073 15.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 EFX05385.1 - 0.011 15.4 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EFX05385.1 - 0.014 14.7 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 EFX05385.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family zf-RING_2 PF13639.1 EFX05386.1 - 5.2e-13 48.5 7.0 8.3e-13 47.9 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EFX05386.1 - 1.8e-07 30.7 4.4 2.9e-07 30.0 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFX05386.1 - 2.4e-07 30.7 4.9 4.7e-07 29.8 3.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EFX05386.1 - 1.6e-05 24.5 4.4 2.5e-05 23.9 3.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EFX05386.1 - 3e-05 23.9 5.9 4.9e-05 23.2 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EFX05386.1 - 4.2e-05 23.1 2.7 6.4e-05 22.5 1.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFX05386.1 - 0.0024 17.6 2.5 0.0055 16.5 1.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 EFX05386.1 - 0.0048 16.4 6.0 0.0079 15.7 4.1 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 EFX05386.1 - 0.11 12.4 3.3 0.28 11.1 2.3 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.24 EFX05386.1 - 0.28 10.9 5.5 0.49 10.1 3.8 1.4 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 EFX05386.1 - 0.58 10.0 5.0 1.2 9.1 3.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 EFX05386.1 - 1.2 9.2 5.9 2.3 8.3 4.1 1.5 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.1 EFX05386.1 - 2.5 7.8 7.9 0.19 11.4 0.8 2.0 1 1 0 2 2 2 0 Prokaryotic RING finger family 1 Acyl-CoA_dh_1 PF00441.19 EFX05387.1 - 4.7e-42 143.6 3.1 7e-42 143.0 2.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EFX05387.1 - 8.7e-28 97.1 0.3 3.8e-27 95.1 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 EFX05387.1 - 1.8e-17 62.5 0.0 3.6e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EFX05387.1 - 6.3e-15 55.6 0.6 1.1e-14 54.8 0.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 EFX05387.1 - 0.041 13.2 0.1 0.22 10.8 0.1 2.0 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal SGL PF08450.7 EFX05390.1 - 1.3e-20 73.8 0.0 2.6e-20 72.8 0.0 1.4 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 EFX05390.1 - 3.1e-05 23.8 0.0 0.00015 21.6 0.0 2.0 2 0 0 2 2 2 1 Arylesterase NHL PF01436.16 EFX05390.1 - 0.00015 21.5 7.5 0.067 13.1 0.0 4.2 4 0 0 4 4 4 2 NHL repeat Str_synth PF03088.11 EFX05390.1 - 0.0013 18.6 0.0 0.0036 17.3 0.0 1.7 1 0 0 1 1 1 1 Strictosidine synthase Reg_prop PF07494.6 EFX05390.1 - 0.056 13.4 0.0 6.2 7.2 0.0 3.5 3 0 0 3 3 3 0 Two component regulator propeller WD40 PF00400.27 EFX05391.1 - 2.5e-22 77.8 8.7 6.9e-06 25.7 0.0 9.1 10 1 0 10 10 10 5 WD domain, G-beta repeat RRF PF01765.14 EFX05391.1 - 1.6e-06 27.7 0.0 2.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Ribosome recycling factor Apc4_WD40 PF12894.2 EFX05391.1 - 0.19 11.2 0.0 17 5.0 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain 2OG-FeII_Oxy_3 PF13640.1 EFX05392.1 - 1.5e-08 35.0 0.0 2.1e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EFX05392.1 - 0.00014 21.4 0.2 0.00029 20.4 0.2 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pro-kuma_activ PF09286.6 EFX05394.1 - 7.7e-42 142.7 0.0 3.5e-41 140.5 0.0 2.1 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFX05394.1 - 6.4e-07 28.8 0.8 1.2e-06 27.9 0.5 1.3 1 0 0 1 1 1 1 Subtilase family Amidohydro_4 PF13147.1 EFX05395.1 - 1.7e-20 74.2 3.2 3.6e-20 73.1 2.2 1.6 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.11 EFX05395.1 - 3.2e-13 49.1 29.9 5e-13 48.4 18.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Amidohydro_5 PF13594.1 EFX05395.1 - 3.3e-13 49.2 1.6 1.2e-12 47.4 1.1 2.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EFX05395.1 - 5.7e-12 45.9 0.4 0.00018 21.2 0.4 2.8 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.6 EFX05395.1 - 8.6e-08 31.8 0.6 0.00019 20.7 0.4 2.8 1 1 0 1 1 1 1 Amidohydrolase family TatD_DNase PF01026.16 EFX05395.1 - 0.074 12.2 0.1 0.17 11.0 0.0 1.6 1 1 0 1 1 1 0 TatD related DNase Abp2 PF09441.5 EFX05396.1 - 3.7e-79 264.7 0.0 6.4e-79 263.9 0.0 1.4 1 0 0 1 1 1 1 ARS binding protein 2 CTP_transf_2 PF01467.21 EFX05397.1 - 9.1e-05 22.5 0.2 0.00085 19.4 0.1 2.3 1 1 0 1 1 1 1 Cytidylyltransferase CorA PF01544.13 EFX05398.1 - 4.8e-12 45.5 0.0 2.3e-10 39.9 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Glyoxalase PF00903.20 EFX05399.1 - 1.8e-10 40.8 0.0 2.4e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFX05399.1 - 2.5e-08 34.5 0.0 4.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 EFX05399.1 - 0.068 13.1 0.0 0.33 11.0 0.0 2.1 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Arf PF00025.16 EFX05400.1 - 1.8e-41 141.2 0.0 7.7e-36 122.9 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Ras PF00071.17 EFX05400.1 - 8.3e-17 61.0 0.0 3.4e-14 52.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 EFX05400.1 - 2.1e-08 34.6 0.0 7.9e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 EFX05400.1 - 7.7e-08 31.4 0.1 1.5e-07 30.5 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.7 EFX05400.1 - 6.1e-07 28.8 0.0 1.2e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EFX05400.1 - 4.6e-05 22.7 0.0 0.094 11.9 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 EFX05400.1 - 5.5e-05 22.6 0.0 0.00018 20.9 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EFX05400.1 - 0.00011 22.1 0.0 0.00039 20.3 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFX05400.1 - 0.17 11.7 0.0 2.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Dynamin family Glutaredoxin PF00462.19 EFX05402.1 - 5.9e-17 61.4 0.0 1.6e-16 60.0 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.15 EFX05402.1 - 8.9e-14 51.0 0.0 2.1e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EFX05402.1 - 0.003 17.6 0.0 0.67 10.1 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EFX05402.1 - 0.0069 16.5 0.0 0.37 10.9 0.0 3.1 1 1 0 1 1 1 1 Thioredoxin-like domain HyaE PF07449.6 EFX05402.1 - 0.07 13.0 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Kelch_4 PF13418.1 EFX05404.1 - 0.00035 20.2 8.6 0.008 15.9 0.1 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Herpes_gE PF02480.11 EFX05404.1 - 0.0041 15.4 0.0 0.0097 14.2 0.0 1.5 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E SKG6 PF08693.5 EFX05404.1 - 0.064 12.5 0.0 0.23 10.8 0.0 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Plasmodium_Vir PF05795.6 EFX05404.1 - 0.13 11.4 0.1 0.27 10.3 0.1 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Abhydrolase_5 PF12695.2 EFX05405.1 - 1.4e-14 54.1 0.2 4.8e-14 52.3 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX05405.1 - 4.3e-13 49.6 4.2 7.3e-13 48.9 2.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX05405.1 - 1.9e-09 37.0 0.1 6.4e-06 25.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.7 EFX05405.1 - 2.3e-08 32.9 0.1 4.3e-06 25.4 0.1 2.5 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.13 EFX05405.1 - 5.1e-08 32.6 0.0 7.6e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) His_Phos_1 PF00300.17 EFX05405.1 - 9.4e-06 25.7 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) BAAT_C PF08840.6 EFX05405.1 - 1.3e-05 24.9 0.0 0.003 17.2 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.15 EFX05405.1 - 0.00032 20.3 0.1 0.00055 19.5 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFX05405.1 - 0.053 13.3 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 Putative lysophospholipase GIIM PF08388.6 EFX05405.1 - 0.074 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Group II intron, maturase-specific domain DLH PF01738.13 EFX05405.1 - 0.08 12.2 0.0 9.9 5.3 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family adh_short PF00106.20 EFX05407.1 - 5.6e-12 45.8 0.0 2.6e-11 43.7 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase TarH PF02203.10 EFX05408.1 - 0.062 13.1 1.4 0.14 11.9 1.0 1.6 1 0 0 1 1 1 0 Tar ligand binding domain homologue CAP_N PF01213.14 EFX05408.1 - 8.5 5.5 6.0 22 4.1 0.2 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal SMC_Nse1 PF07574.8 EFX05409.1 - 5.4e-27 94.7 0.0 7.2e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 EFX05409.1 - 3.4e-07 30.1 6.8 6e-07 29.3 4.7 1.4 1 0 0 1 1 1 1 RING-like domain C1_1 PF00130.17 EFX05409.1 - 0.015 14.9 2.9 0.034 13.8 2.0 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.1 EFX05409.1 - 0.13 12.0 6.0 0.25 11.1 4.1 1.5 1 0 0 1 1 1 0 Ring finger domain DEAD PF00270.24 EFX05410.1 - 1.3e-17 63.7 0.0 4.4e-17 62.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EFX05410.1 - 3.4e-10 40.0 0.0 9.8e-10 38.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EFX05410.1 - 1.3e-07 31.4 1.2 2.5e-07 30.4 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PhoH PF02562.11 EFX05410.1 - 0.1 11.8 0.0 0.24 10.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein RhoGEF PF00621.15 EFX05411.1 - 3.9e-24 85.5 0.0 1e-23 84.1 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.3 EFX05411.1 - 6.7e-06 25.7 0.0 1.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DUF3313 PF11769.3 EFX05411.1 - 0.019 14.3 0.7 0.039 13.3 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Pyr_redox_2 PF07992.9 EFX05412.1 - 1.7e-24 86.8 1.4 3.1e-24 85.9 0.9 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.1 EFX05412.1 - 5.1e-17 61.5 0.0 1.8e-16 59.7 0.0 2.0 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain Fer2_BFD PF04324.10 EFX05412.1 - 8.4e-17 60.9 8.4 1.2e-12 47.6 3.1 2.6 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain NIR_SIR PF01077.17 EFX05412.1 - 4.2e-15 55.4 0.0 1.1e-10 41.0 0.0 2.6 1 1 1 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.22 EFX05412.1 - 4.4e-13 49.4 7.7 2e-12 47.3 1.7 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.21 EFX05412.1 - 1.2e-12 47.2 0.1 6.4e-12 44.8 0.0 2.3 3 0 0 3 3 3 1 Rieske [2Fe-2S] domain NIR_SIR_ferr PF03460.12 EFX05412.1 - 6.3e-10 38.5 0.0 1.7e-09 37.1 0.0 1.8 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Pyr_redox_3 PF13738.1 EFX05412.1 - 0.0001 22.4 0.6 0.027 14.5 0.2 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX05412.1 - 0.0003 20.5 0.6 1.1 9.0 0.0 3.5 2 1 1 3 3 3 2 FAD-NAD(P)-binding NAD_binding_7 PF13241.1 EFX05412.1 - 0.015 15.5 1.0 0.36 11.1 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.1 EFX05412.1 - 0.026 14.5 0.8 1.1 9.3 0.1 3.2 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.16 EFX05412.1 - 0.029 13.9 2.1 1.4 8.4 0.0 3.1 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.13 EFX05412.1 - 0.11 12.5 4.0 6.1 6.8 0.1 3.3 4 0 0 4 4 4 0 TrkA-N domain DUF2611 PF11022.3 EFX05413.1 - 3.9e-27 94.1 0.1 4.2e-27 94.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) Abhydrolase_6 PF12697.2 EFX05414.1 - 6.6e-20 71.9 0.0 7.9e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05414.1 - 2.6e-14 53.3 0.1 2.7e-12 46.7 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX05414.1 - 1.5e-06 28.0 0.0 5e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 EFX05414.1 - 0.0006 18.3 0.0 0.0012 17.4 0.0 1.4 1 1 0 1 1 1 1 Ndr family Spc97_Spc98 PF04130.8 EFX05415.1 - 6.8e-75 252.4 0.0 8.7e-75 252.0 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Mito_fiss_reg PF05308.6 EFX05415.1 - 0.027 13.8 0.0 7.7 5.8 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator Tubulin_3 PF14881.1 EFX05416.1 - 5.6e-71 237.7 0.0 8.6e-71 237.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 EFX05416.1 - 1.2e-39 134.9 0.0 2.9e-39 133.7 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 EFX05416.1 - 0.00012 21.9 0.0 0.0019 18.0 0.0 2.2 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Sigma70_ner PF04546.8 EFX05416.1 - 0.21 11.1 1.5 0.36 10.4 1.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EFX05416.1 - 0.33 11.3 7.3 0.77 10.1 5.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NGP1NT PF08153.7 EFX05417.1 - 9.8e-40 135.5 0.9 2.1e-39 134.4 0.1 1.9 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 EFX05417.1 - 3.6e-21 75.2 0.0 2.1e-16 59.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 EFX05417.1 - 2.3e-06 27.5 0.0 0.0032 17.2 0.0 3.4 2 1 1 3 3 3 1 Dynamin family FeoB_N PF02421.13 EFX05417.1 - 5.6e-06 25.7 0.0 2.4e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EFX05417.1 - 0.00068 19.1 0.0 0.069 12.5 0.0 3.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EFX05417.1 - 0.0012 18.0 0.0 0.0026 16.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Arf PF00025.16 EFX05417.1 - 0.0024 17.1 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family AIG1 PF04548.11 EFX05417.1 - 0.024 13.7 0.0 0.15 11.1 0.0 2.2 3 0 0 3 3 3 0 AIG1 family Dehydrin PF00257.14 EFX05418.1 - 0.02 15.2 0.7 0.02 15.2 0.5 1.1 1 0 0 1 1 1 0 Dehydrin Mucin PF01456.12 EFX05418.1 - 0.88 9.3 22.9 0.018 14.8 10.0 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein TMEM154 PF15102.1 EFX05418.1 - 1 9.0 3.4 1.5 8.4 2.4 1.3 1 0 0 1 1 1 0 TMEM154 protein family DnaJ PF00226.26 EFX05419.1 - 1.9e-23 81.9 4.2 8.3e-23 79.9 2.9 2.2 1 0 0 1 1 1 1 DnaJ domain zf-HIT PF04438.11 EFX05419.1 - 0.037 13.6 2.9 0.065 12.8 2.0 1.4 1 0 0 1 1 1 0 HIT zinc finger Spo0A_C PF08769.6 EFX05419.1 - 4.1 7.3 8.5 12 5.8 3.1 3.3 3 1 0 3 3 3 0 Sporulation initiation factor Spo0A C terminal TRM PF02005.11 EFX05420.1 - 3e-105 352.2 0.0 7.1e-105 351.0 0.0 1.6 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_26 PF13659.1 EFX05420.1 - 2.6e-05 24.2 0.1 8.4e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX05420.1 - 0.032 13.6 0.0 0.28 10.5 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_3 PF01596.12 EFX05420.1 - 0.097 11.7 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Met_10 PF02475.11 EFX05420.1 - 0.2 11.2 0.2 0.55 9.8 0.0 1.8 2 0 0 2 2 2 0 Met-10+ like-protein CDC45 PF02724.9 EFX05420.1 - 0.69 7.8 3.9 1.2 7.1 2.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Mo-co_dimer PF03404.11 EFX05421.1 - 2.7e-55 185.5 0.1 4.9e-55 184.7 0.1 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.14 EFX05421.1 - 6.5e-51 172.0 0.0 1.1e-50 171.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.19 EFX05421.1 - 1.1e-27 95.9 0.0 2e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 EFX05421.1 - 2.5e-24 84.8 0.0 5.5e-24 83.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 EFX05421.1 - 6.8e-24 84.5 0.0 2.8e-23 82.5 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EFX05421.1 - 1.3e-05 25.1 0.0 0.015 15.1 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain p450 PF00067.17 EFX05422.1 - 8.5e-77 258.6 0.0 1e-76 258.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-MYND PF01753.13 EFX05423.1 - 5.5e-05 22.9 5.6 0.00016 21.4 3.9 1.8 1 0 0 1 1 1 1 MYND finger Kri1_C PF12936.2 EFX05425.1 - 9.1e-27 92.8 0.0 9.1e-27 92.8 0.0 4.5 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.7 EFX05425.1 - 1.6e-22 79.6 21.2 1.6e-22 79.6 14.7 5.6 5 4 2 7 7 7 1 KRI1-like family Acetyltransf_1 PF00583.19 EFX05426.1 - 3.8e-10 39.6 0.0 6.2e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX05426.1 - 0.00054 20.0 0.1 0.00096 19.2 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RCC1 PF00415.13 EFX05427.1 - 4.9e-09 36.2 2.5 0.0054 16.9 0.2 3.3 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EFX05427.1 - 2.5e-06 26.9 1.3 4.8e-05 22.8 0.5 2.4 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat Ribosomal_S5 PF00333.15 EFX05427.1 - 0.0097 15.6 0.2 0.017 14.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain SH3_9 PF14604.1 EFX05428.1 - 3.9e-28 96.7 4.3 7e-15 54.3 0.3 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 EFX05428.1 - 8.5e-23 79.4 3.6 8.4e-12 44.2 0.2 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 EFX05428.1 - 1.9e-15 56.1 0.2 1.8e-06 27.3 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.15 EFX05428.1 - 6.6e-12 45.4 0.0 1.2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamin_M PF01031.15 EFX05429.1 - 6.1e-114 379.7 0.0 1.1e-113 378.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 EFX05429.1 - 2.5e-55 186.8 0.0 5.2e-55 185.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 EFX05429.1 - 2.6e-31 107.3 1.2 6.8e-31 106.0 0.8 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EFX05429.1 - 0.00033 20.5 0.2 0.0015 18.4 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EFX05429.1 - 0.024 15.1 0.0 0.06 13.8 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein zf-CCHC_4 PF14392.1 EFX05429.1 - 0.15 11.7 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle Thioredoxin PF00085.15 EFX05430.1 - 1.7e-62 207.5 8.4 2.5e-31 107.4 0.1 4.3 4 1 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.1 EFX05430.1 - 1.3e-51 174.9 3.0 9.1e-37 126.6 0.6 3.3 2 2 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX05430.1 - 8.9e-12 44.9 0.2 0.0018 18.3 0.0 4.3 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.1 EFX05430.1 - 1.3e-11 44.3 0.8 5.8e-05 23.0 0.0 3.6 4 0 0 4 4 4 2 Thioredoxin-like Calsequestrin PF01216.12 EFX05430.1 - 8.6e-10 37.9 2.7 9.3e-10 37.8 0.9 1.7 2 0 0 2 2 2 1 Calsequestrin Redoxin PF08534.5 EFX05430.1 - 1.5e-09 37.5 4.4 0.016 14.7 0.0 3.4 3 0 0 3 3 3 3 Redoxin AhpC-TSA PF00578.16 EFX05430.1 - 2.2e-09 37.0 2.9 0.0067 16.1 0.1 3.6 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_2 PF13098.1 EFX05430.1 - 3.1e-09 37.0 6.0 0.0015 18.6 0.1 4.6 2 2 1 3 3 3 2 Thioredoxin-like domain ERp29_N PF07912.8 EFX05430.1 - 0.00055 19.8 0.4 2.5 8.0 0.0 4.1 3 2 0 3 3 3 1 ERp29, N-terminal domain Thioredoxin_4 PF13462.1 EFX05430.1 - 0.00064 19.7 5.8 0.051 13.5 0.1 3.5 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_3 PF13192.1 EFX05430.1 - 0.018 14.8 0.7 0.31 10.8 0.0 2.8 2 1 0 2 2 2 0 Thioredoxin domain PepX_N PF09168.5 EFX05430.1 - 0.054 13.7 0.1 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal Ribosomal_S17e PF00833.13 EFX05431.1 - 3.5e-58 194.6 0.4 4.3e-58 194.3 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 Cryptochrome_C PF12546.3 EFX05431.1 - 0.012 16.3 0.0 0.017 15.8 0.0 1.2 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal Metallophos PF00149.23 EFX05432.1 - 2.6e-38 131.4 0.5 3.7e-38 130.9 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pro-rich PF15240.1 EFX05433.1 - 1.4 9.0 26.1 1.6 8.8 18.1 1.1 1 0 0 1 1 1 0 Proline-rich PSDC PF12588.3 EFX05434.1 - 2.8e-47 159.8 0.0 4e-47 159.3 0.0 1.2 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.10 EFX05434.1 - 9.8e-34 116.4 0.0 1.7e-33 115.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.1 EFX05434.1 - 0.0052 16.4 0.1 0.46 10.1 0.1 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like Chromo_shadow PF01393.14 EFX05435.1 - 1.6e-15 56.6 0.0 8.9e-12 44.6 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.19 EFX05435.1 - 3.4e-11 42.6 0.0 8.4e-11 41.3 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1176 PF06674.6 EFX05435.1 - 0.052 12.6 0.0 0.074 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1176) ubiquitin PF00240.18 EFX05436.1 - 6e-05 22.3 0.0 0.00011 21.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.5 EFX05436.1 - 0.049 14.1 0.0 0.085 13.4 0.0 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD MIP-T3 PF10243.4 EFX05436.1 - 0.43 8.9 31.2 0.55 8.6 21.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ribosomal_S15 PF00312.17 EFX05437.1 - 7.5e-14 51.2 0.3 5.3e-13 48.5 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein S15 DUF3827 PF12877.2 EFX05437.1 - 0.056 11.5 0.3 0.09 10.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) zf-C2H2 PF00096.21 EFX05438.1 - 4.6e-06 26.6 13.3 0.00042 20.5 0.3 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX05438.1 - 0.0093 16.2 0.7 0.0093 16.2 0.5 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EFX05438.1 - 0.035 13.9 0.7 0.081 12.8 0.0 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EFX05438.1 - 0.056 13.5 3.7 0.13 12.3 2.5 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) polyprenyl_synt PF00348.12 EFX05439.1 - 1.4e-54 184.7 0.1 2.2e-51 174.2 0.0 2.2 2 0 0 2 2 2 2 Polyprenyl synthetase HEPPP_synt_1 PF07307.6 EFX05439.1 - 0.041 13.3 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Big_2 PF02368.13 EFX05439.1 - 0.37 10.6 3.0 1.2 9.0 0.5 2.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 2) Kinesin PF00225.18 EFX05440.1 - 5.9e-112 373.6 0.0 8.4e-112 373.1 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain DUF837 PF05769.6 EFX05440.1 - 0.011 15.2 6.3 0.022 14.2 4.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF837) Virulence_RhuM PF13310.1 EFX05440.1 - 0.026 13.5 1.7 0.057 12.4 1.2 1.5 1 0 0 1 1 1 0 Virulence protein RhuM family Fib_alpha PF08702.5 EFX05440.1 - 0.052 13.6 4.9 0.13 12.3 3.4 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family GAS PF13851.1 EFX05440.1 - 0.099 11.8 7.1 0.19 10.8 4.9 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF87 PF01935.12 EFX05440.1 - 0.72 9.6 4.4 0.76 9.5 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF87 MFS_1 PF07690.11 EFX05441.1 - 3.7e-29 101.5 28.1 3.7e-29 101.5 19.5 3.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05441.1 - 8e-07 27.9 8.2 1.3e-06 27.2 5.7 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 EFX05441.1 - 0.11 10.8 17.1 0.0047 15.3 6.2 2.2 2 0 0 2 2 2 0 MFS/sugar transport protein DUF4231 PF14015.1 EFX05441.1 - 7.5 6.5 12.4 17 5.4 1.0 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) Smr PF01713.16 EFX05443.1 - 0.00037 20.6 0.1 0.0008 19.5 0.1 1.6 1 0 0 1 1 1 1 Smr domain CUE PF02845.11 EFX05443.1 - 0.0056 16.1 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF1771 PF08590.5 EFX05443.1 - 0.0064 16.4 8.6 0.018 15.0 6.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Solute_trans_a PF03619.11 EFX05444.1 - 1.3e-81 273.9 23.3 1.5e-81 273.7 16.2 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha MMS1_N PF10433.4 EFX05445.1 - 1.2e-88 297.5 0.0 1.9e-88 296.8 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 EFX05445.1 - 6.3e-58 196.3 0.0 2.6e-29 102.3 0.0 2.7 2 0 0 2 2 2 2 CPSF A subunit region R3H-assoc PF13902.1 EFX05445.1 - 3.1e-20 72.4 2.1 6.3e-20 71.4 1.4 1.5 1 0 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.17 EFX05445.1 - 0.0034 17.0 0.0 0.0083 15.7 0.0 1.6 1 0 0 1 1 1 1 R3H domain Cation_efflux PF01545.16 EFX05446.1 - 7e-55 186.1 0.2 9.3e-55 185.6 0.2 1.1 1 0 0 1 1 1 1 Cation efflux family Eaf7 PF07904.8 EFX05447.1 - 1.1e-22 79.8 0.0 1.9e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 MARVEL PF01284.18 EFX05448.1 - 0.041 13.6 20.3 0.058 13.2 14.0 1.2 1 0 0 1 1 1 0 Membrane-associating domain 7TMR-DISM_7TM PF07695.6 EFX05448.1 - 0.14 11.7 19.0 0.77 9.4 8.5 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling DUF4293 PF14126.1 EFX05448.1 - 5 7.0 8.1 1.3 8.9 3.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Methyltransf_23 PF13489.1 EFX05449.1 - 4.7e-23 81.6 0.0 8.6e-23 80.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05449.1 - 3.5e-11 42.9 0.0 2.5e-10 40.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05449.1 - 8.7e-10 39.1 0.0 1.1e-08 35.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05449.1 - 1.2e-08 35.3 0.0 9.9e-08 32.3 0.0 2.5 3 1 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05449.1 - 2.6e-08 34.2 0.0 9.5e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05449.1 - 3.5e-05 23.8 0.0 0.00059 19.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05449.1 - 9.2e-05 22.7 0.0 0.00029 21.1 0.0 1.9 2 1 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 EFX05449.1 - 0.00092 18.6 0.0 0.0097 15.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.4 EFX05449.1 - 0.0032 16.9 0.0 0.0075 15.7 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase PrmA PF06325.8 EFX05449.1 - 0.0063 15.6 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 EFX05449.1 - 0.014 14.4 0.0 0.41 9.6 0.0 2.3 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.14 EFX05449.1 - 0.03 14.2 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Xpo1 PF08389.7 EFX05450.1 - 1.7e-26 92.8 5.4 2.4e-26 92.3 0.1 3.6 4 1 1 5 5 5 1 Exportin 1-like protein Adaptin_N PF01602.15 EFX05450.1 - 1.6e-06 26.7 0.8 0.00027 19.3 0.1 2.5 3 0 0 3 3 3 2 Adaptin N terminal region UME PF08064.8 EFX05450.1 - 0.025 14.5 1.0 9.8 6.1 0.0 3.5 3 0 0 3 3 3 0 UME (NUC010) domain GTP_EFTU PF00009.22 EFX05451.1 - 2.6e-53 180.2 0.0 4.1e-53 179.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 EFX05451.1 - 4.2e-18 64.9 0.0 7.6e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 EFX05451.1 - 6.9e-12 45.0 0.0 1.4e-05 24.8 0.0 2.6 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFX05451.1 - 0.00028 20.9 0.0 0.0008 19.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX05451.1 - 0.038 13.9 0.0 0.1 12.5 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF2248 PF10005.4 EFX05451.1 - 0.071 12.0 0.2 2.8 6.7 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2248) SRF-TF PF00319.13 EFX05453.1 - 5.4e-23 79.9 0.2 8e-23 79.4 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Cu-oxidase_2 PF07731.9 EFX05454.1 - 1.8e-09 37.1 0.6 8.6e-09 35.0 0.0 2.3 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 EFX05454.1 - 0.0078 16.1 0.0 0.038 13.8 0.0 2.2 2 0 0 2 2 2 1 Multicopper oxidase EF-hand_8 PF13833.1 EFX05455.1 - 0.00019 20.9 0.1 0.48 10.0 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 EFX05455.1 - 0.013 15.6 0.0 0.28 11.3 0.0 2.4 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_9 PF14658.1 EFX05455.1 - 0.015 15.1 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain EF-hand_6 PF13405.1 EFX05455.1 - 0.018 14.9 0.2 9.5 6.4 0.0 3.3 3 1 0 3 3 3 0 EF-hand domain IBR PF01485.16 EFX05456.1 - 6.1e-07 29.2 39.2 1.8e-06 27.6 4.2 3.6 3 1 0 3 3 3 2 IBR domain RAP1 PF07218.6 EFX05456.1 - 9.3 4.1 5.1 15 3.4 3.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Cation_efflux PF01545.16 EFX05457.1 - 8.9e-74 248.1 7.7 1e-73 247.9 5.4 1.0 1 0 0 1 1 1 1 Cation efflux family Sec61_beta PF03911.11 EFX05457.1 - 1 9.2 4.7 1.1 9.1 0.6 2.8 2 0 0 2 2 2 0 Sec61beta family vATP-synt_AC39 PF01992.11 EFX05458.1 - 2.4e-116 388.5 0.0 2.7e-116 388.3 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit SMC_Nse1 PF07574.8 EFX05458.1 - 0.1 12.2 0.0 0.56 9.7 0.0 1.9 2 0 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex Tht1 PF04163.7 EFX05460.1 - 0.00082 17.8 0.1 0.00082 17.8 0.1 3.2 4 0 0 4 4 4 1 Tht1-like nuclear fusion protein zf-RING_2 PF13639.1 EFX05461.1 - 7.2e-12 44.9 8.5 1.7e-11 43.7 5.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EFX05461.1 - 4.6e-06 26.6 1.7 1.3e-05 25.2 1.2 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EFX05461.1 - 5.8e-06 26.2 9.1 1.1e-05 25.2 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX05461.1 - 1.6e-05 24.4 8.7 3.6e-05 23.3 6.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX05461.1 - 4e-05 23.2 7.1 8.1e-05 22.2 4.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EFX05461.1 - 0.00013 21.5 5.8 0.00026 20.5 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EFX05461.1 - 0.0014 18.4 1.7 0.0031 17.3 1.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 EFX05461.1 - 0.0017 18.0 1.7 0.0028 17.3 0.5 1.9 1 1 1 2 2 2 1 RING-type zinc-finger stn_TNFRSF12A PF12191.3 EFX05461.1 - 0.028 14.4 0.1 0.066 13.2 0.1 1.6 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain zf-C3HC4_4 PF15227.1 EFX05461.1 - 0.21 11.5 9.8 0.41 10.5 6.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.1 EFX05461.1 - 0.34 10.6 2.9 1.1 9.0 2.0 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 YdjO PF14169.1 EFX05461.1 - 1.1 8.6 3.7 7.7 6.0 0.8 2.7 2 1 1 3 3 3 0 Cold-inducible protein YdjO PHD PF00628.24 EFX05461.1 - 1.3 8.8 5.7 2.4 7.9 4.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.1 EFX05461.1 - 1.6 8.3 6.2 3.1 7.4 4.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 EFX05461.1 - 1.7 8.7 6.0 3.2 7.8 4.2 1.5 1 0 0 1 1 1 0 RING-variant domain FAR1 PF03101.10 EFX05462.1 - 4.3e-07 30.3 0.1 1.1e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 FAR1 DNA-binding domain Med9 PF07544.8 EFX05462.1 - 0.00034 20.2 2.4 0.0009 18.9 1.6 1.8 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 MEDS PF14417.1 EFX05462.1 - 0.082 11.9 0.2 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain IncA PF04156.9 EFX05462.1 - 2.5 7.6 8.1 1.7 8.2 1.3 2.4 2 0 0 2 2 2 0 IncA protein HIG_1_N PF04588.8 EFX05463.1 - 4e-06 26.4 2.0 4e-06 26.4 1.4 1.9 2 0 0 2 2 2 1 Hypoxia induced protein conserved region Amidase PF01425.16 EFX05466.1 - 4e-68 230.2 0.0 5.5e-68 229.8 0.0 1.1 1 0 0 1 1 1 1 Amidase p450 PF00067.17 EFX05467.1 - 1.3e-27 96.4 0.0 1.5e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_2 PF02230.11 EFX05468.1 - 8.1e-29 100.6 0.2 2.4e-17 63.0 0.3 3.0 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 EFX05468.1 - 2.1e-08 33.6 0.1 4.8e-08 32.4 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EFX05468.1 - 6.9e-07 29.3 0.4 6e-06 26.3 0.3 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIP PF03583.9 EFX05468.1 - 3.9e-06 26.2 0.0 6.4e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_5 PF12695.2 EFX05468.1 - 2.5e-05 24.0 0.0 0.00022 20.9 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 EFX05468.1 - 0.00032 20.1 0.0 0.00061 19.2 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.13 EFX05468.1 - 0.0018 17.5 0.0 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 EFX05468.1 - 0.013 15.0 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.6 EFX05468.1 - 0.017 14.8 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_4 PF08386.5 EFX05468.1 - 0.094 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein DHO_dh PF01180.16 EFX05469.1 - 3.5e-62 210.0 0.0 3.5e-50 170.6 0.0 2.2 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Mpv17_PMP22 PF04117.7 EFX05469.1 - 3.6e-12 45.7 0.2 1.1e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 Mpv17 / PMP22 family zf-RING_5 PF14634.1 EFX05469.1 - 0.0012 18.5 3.5 0.0036 16.9 2.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain FMN_dh PF01070.13 EFX05469.1 - 0.0014 17.6 0.4 0.0066 15.3 0.1 2.0 2 0 0 2 2 2 1 FMN-dependent dehydrogenase zf-RING_2 PF13639.1 EFX05469.1 - 0.0036 17.0 3.5 0.013 15.3 2.4 1.9 1 0 0 1 1 1 1 Ring finger domain PcrB PF01884.12 EFX05469.1 - 0.012 14.9 0.3 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 PcrB family zf-C3HC4 PF00097.20 EFX05469.1 - 0.019 14.6 4.2 0.077 12.6 2.9 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EFX05469.1 - 0.095 12.4 3.0 0.23 11.1 2.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Methyltransf_4 PF02390.12 EFX05470.1 - 4.5e-48 162.9 0.0 6.1e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase FmrO PF07091.6 EFX05470.1 - 0.00021 20.3 0.0 0.00058 18.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_26 PF13659.1 EFX05470.1 - 0.013 15.5 0.1 0.03 14.3 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 EFX05470.1 - 0.017 14.7 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05470.1 - 0.06 13.9 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain GTP_EFTU PF00009.22 EFX05471.1 - 4.5e-54 182.7 0.1 8.8e-54 181.8 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 EFX05471.1 - 1.4e-31 108.1 0.0 2.6e-31 107.2 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 EFX05471.1 - 1.6e-26 92.2 0.0 5.6e-26 90.4 0.0 2.0 1 1 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 EFX05471.1 - 9.9e-22 76.6 0.0 2e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EFX05471.1 - 9.2e-16 57.7 0.1 2.3e-15 56.4 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DUF442 PF04273.8 EFX05471.1 - 0.052 13.3 0.1 2.9 7.8 0.0 3.5 4 0 0 4 4 4 0 Putative phosphatase (DUF442) DUF3129 PF11327.3 EFX05472.1 - 3.9e-23 82.2 4.3 4.8e-23 81.9 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3129) Peptidase_C25_C PF03785.9 EFX05472.1 - 0.096 12.5 4.4 0.082 12.7 1.9 1.7 1 1 1 2 2 2 0 Peptidase family C25, C terminal ig-like domain Trehalase PF01204.13 EFX05473.1 - 8.7e-118 394.1 2.6 9.9e-117 390.6 1.8 2.0 1 1 0 1 1 1 1 Trehalase Mqo PF06039.10 EFX05473.1 - 0.088 10.9 0.0 0.13 10.3 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) MFS_1 PF07690.11 EFX05474.1 - 1e-26 93.5 48.5 1.6e-26 92.8 33.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05474.1 - 0.086 11.4 32.6 0.81 8.1 22.6 2.2 1 1 0 1 1 1 0 Sugar (and other) transporter Ferric_reduct PF01794.14 EFX05475.1 - 5.4e-18 65.2 16.5 5.4e-18 65.2 11.4 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EFX05475.1 - 4.2e-09 36.2 0.0 5.5e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_6 PF08030.7 EFX05475.1 - 1.7e-07 31.2 0.0 1.6e-05 24.8 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain DUF3487 PF11990.3 EFX05475.1 - 8.4 5.8 9.9 0.5 9.7 2.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) Abhydrolase_3 PF07859.8 EFX05476.1 - 1.3e-50 171.9 2.6 1.6e-50 171.6 0.0 2.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold TPR_MLP1_2 PF07926.7 EFX05476.1 - 1.9e-27 95.6 24.6 1.9e-27 95.6 17.0 16.8 6 3 13 20 20 20 3 TPR/MLP1/MLP2-like protein COesterase PF00135.23 EFX05476.1 - 6.9e-10 38.2 0.0 5.9e-09 35.1 0.0 2.7 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EFX05476.1 - 5.3e-05 23.0 0.5 0.00017 21.3 0.3 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family ADIP PF11559.3 EFX05476.1 - 0.00065 19.6 6.5 0.00065 19.6 4.5 20.2 8 4 12 20 20 20 4 Afadin- and alpha -actinin-Binding HALZ PF02183.13 EFX05476.1 - 0.0032 17.1 0.9 0.0032 17.1 0.6 17.0 21 2 1 22 22 22 3 Homeobox associated leucine zipper DUF2424 PF10340.4 EFX05476.1 - 0.14 10.7 0.0 0.26 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) PHD_2 PF13831.1 EFX05476.1 - 0.32 10.3 0.0 0.76 9.1 0.0 1.6 1 0 0 1 1 1 0 PHD-finger RNA_pol_Rpc82 PF05645.8 EFX05477.1 - 3e-42 144.9 0.0 3.5e-40 138.1 0.0 2.2 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 EFX05477.1 - 3e-16 59.0 1.1 6.1e-14 51.6 0.0 3.5 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.12 EFX05477.1 - 9.5e-06 25.0 0.0 0.064 12.7 0.0 3.3 2 1 1 3 3 3 2 TFIIE alpha subunit HTH_20 PF12840.2 EFX05477.1 - 0.57 10.0 7.8 0.71 9.7 0.3 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain Spc97_Spc98 PF04130.8 EFX05478.1 - 6.8e-66 222.7 0.0 8.6e-66 222.3 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Ank_2 PF12796.2 EFX05479.1 - 3.9e-104 341.2 24.4 3.2e-23 81.8 0.5 5.9 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFX05479.1 - 4e-84 272.4 28.2 6e-10 38.4 0.1 10.4 10 0 0 10 10 10 9 Ankyrin repeat Ank_3 PF13606.1 EFX05479.1 - 2.1e-70 225.5 7.1 2.2e-07 30.4 0.1 11.0 12 0 0 12 12 10 9 Ankyrin repeat Ank_4 PF13637.1 EFX05479.1 - 4.8e-59 195.7 23.5 1.1e-10 41.6 0.0 9.6 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX05479.1 - 4e-58 192.1 34.0 4.9e-12 45.6 0.1 7.4 2 2 4 7 7 7 7 Ankyrin repeats (many copies) NACHT PF05729.7 EFX05479.1 - 1.9e-11 43.9 0.1 8.6e-09 35.2 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EFX05479.1 - 7.8e-07 29.2 0.4 4.4e-06 26.8 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF4432 PF14486.1 EFX05479.1 - 2.5e-05 22.9 0.8 15 4.0 0.0 6.8 4 2 3 8 8 8 0 Domain of unknown function (DUF4432) AAA_22 PF13401.1 EFX05479.1 - 4.3e-05 23.6 0.1 0.00026 21.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain RVP PF00077.15 EFX05479.1 - 5e-05 23.1 17.0 3 7.8 0.1 7.2 1 1 6 7 7 7 2 Retroviral aspartyl protease UBA PF00627.26 EFX05479.1 - 0.0024 17.6 0.0 1.7e+02 2.2 0.0 6.4 7 0 0 7 7 7 0 UBA/TS-N domain AAA PF00004.24 EFX05479.1 - 0.0046 17.1 0.0 0.037 14.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CTD PF12815.2 EFX05479.1 - 0.0049 17.2 0.7 9.4 6.6 0.0 3.3 1 1 0 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Arch_ATPase PF01637.13 EFX05479.1 - 0.016 14.9 0.1 0.19 11.4 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase Sigma54_activ_2 PF14532.1 EFX05479.1 - 0.07 13.1 0.0 0.26 11.3 0.0 2.0 1 0 0 1 1 1 0 Sigma-54 interaction domain DsrD PF08679.6 EFX05479.1 - 0.1 12.6 3.1 0.24 11.4 2.1 1.6 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) AAA_14 PF13173.1 EFX05479.1 - 0.1 12.5 0.2 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 EFX05479.1 - 0.2 10.5 3.9 0.24 10.3 0.1 2.4 2 1 0 3 3 3 0 KAP family P-loop domain FAD_binding_3 PF01494.14 EFX05480.1 - 3.3e-82 276.3 0.0 4.2e-82 276.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX05480.1 - 0.00078 19.3 0.6 0.0019 18.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX05480.1 - 0.0028 16.6 0.0 0.038 12.8 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX05480.1 - 0.02 14.8 1.0 0.066 13.2 0.7 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX05480.1 - 0.071 11.9 0.1 0.13 11.0 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.12 EFX05480.1 - 0.094 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DUF3804 PF12707.2 EFX05480.1 - 0.094 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) GIDA PF01134.17 EFX05480.1 - 0.54 9.0 2.2 1.2 7.8 0.5 2.1 3 0 0 3 3 3 0 Glucose inhibited division protein A Upf2 PF04050.9 EFX05482.1 - 1.5e-53 181.0 18.1 1.5e-53 181.0 12.5 2.7 3 0 0 3 3 3 1 Up-frameshift suppressor 2 MIF4G PF02854.14 EFX05482.1 - 1.2e-46 158.7 0.0 1.3e-23 83.5 0.0 3.3 3 0 0 3 3 3 3 MIF4G domain DUF4419 PF14388.1 EFX05483.1 - 7.6e-97 324.1 0.0 8.8e-97 323.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) TRAP-gamma PF07074.7 EFX05483.1 - 0.053 13.0 0.1 0.082 12.4 0.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Cytochrom_C1 PF02167.10 EFX05484.1 - 3.1e-80 268.9 0.0 3.8e-80 268.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 EFX05484.1 - 0.0066 16.5 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 EFX05484.1 - 0.063 14.1 0.4 0.26 12.1 0.1 2.2 2 1 0 2 2 2 0 Cytochrome c GTP_EFTU PF00009.22 EFX05485.1 - 2.4e-31 108.6 0.0 1.2e-30 106.3 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EFX05485.1 - 3e-18 65.6 0.0 8e-18 64.3 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EFX05485.1 - 4.4e-09 36.3 7.8 7.4e-07 29.1 0.1 3.5 4 0 0 4 4 4 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EFX05485.1 - 3.1e-06 27.1 0.1 1.4e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 EFX05485.1 - 0.00078 19.0 0.1 0.0029 17.1 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Miro PF08477.8 EFX05485.1 - 0.0013 19.2 0.0 0.0077 16.7 0.0 2.4 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 EFX05485.1 - 0.042 13.9 0.4 0.32 11.1 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EFX05485.1 - 0.097 12.6 0.0 0.097 12.6 0.0 3.3 2 1 0 2 2 2 0 AAA ATPase domain Sugar_tr PF00083.19 EFX05486.1 - 2.3e-34 118.7 27.9 3.3e-32 111.6 19.3 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05486.1 - 6.7e-21 74.3 41.4 4.8e-12 45.2 9.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_18 PF00704.23 EFX05487.1 - 1.5e-68 231.8 3.7 2.8e-68 230.8 2.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 EFX05487.1 - 3e-07 30.2 11.4 3e-07 30.2 7.9 5.4 4 1 1 5 5 5 1 Chitin recognition protein PQQ_3 PF13570.1 EFX05488.1 - 7.3e-05 22.8 2.5 10 6.5 0.1 5.3 5 0 0 5 5 5 2 PQQ-like domain WD40 PF00400.27 EFX05488.1 - 0.00019 21.2 6.3 0.12 12.2 0.1 5.1 6 0 0 6 6 6 1 WD domain, G-beta repeat Nop14 PF04147.7 EFX05488.1 - 0.034 12.0 8.2 0.048 11.6 5.7 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 EFX05488.1 - 0.46 8.4 15.8 0.62 8.0 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.10 EFX05488.1 - 1.2 8.6 10.7 1.7e+02 1.6 7.0 2.6 2 1 0 2 2 2 0 Nucleoplasmin PI31_Prot_N PF11566.3 EFX05489.1 - 2e-25 89.2 0.0 2.6e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.6 EFX05489.1 - 6.3e-15 55.5 19.3 6.3e-15 55.5 13.4 3.0 2 1 0 2 2 2 1 PI31 proteasome regulator WD40 PF00400.27 EFX05490.1 - 0.00078 19.2 0.2 0.0019 18.0 0.1 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat TIR_2 PF13676.1 EFX05490.1 - 0.072 13.2 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 TIR domain CytochromB561_N PF09786.4 EFX05490.1 - 6.8 5.0 6.2 23 3.2 4.3 1.8 1 0 0 1 1 1 0 Cytochrome B561, N terminal MS_channel PF00924.13 EFX05491.1 - 6e-19 68.1 1.6 1.1e-18 67.3 1.1 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.1 EFX05491.1 - 0.0081 15.4 1.0 0.013 14.8 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.27 EFX05491.1 - 0.011 15.0 0.1 0.03 13.6 0.0 1.8 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 EFX05491.1 - 0.12 12.3 0.0 0.47 10.4 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain TauD PF02668.11 EFX05492.1 - 5.1e-28 98.4 0.0 7.2e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Rad4 PF03835.10 EFX05493.1 - 1.4e-30 105.6 0.3 5.3e-30 103.7 0.2 2.0 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EFX05493.1 - 8.9e-27 92.6 0.1 1.6e-26 91.8 0.1 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 EFX05493.1 - 1.6e-19 69.1 0.2 3.6e-19 68.0 0.2 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EFX05493.1 - 7.7e-15 54.9 0.6 7.7e-15 54.9 0.4 3.0 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 EFX05493.1 - 0.028 14.6 0.0 0.13 12.5 0.0 2.4 2 1 0 2 2 2 0 Transglutaminase-like superfamily Glyco_hydro_7 PF00840.15 EFX05494.1 - 2.5e-94 316.0 1.2 1.3e-92 310.4 0.3 2.6 1 1 1 2 2 2 2 Glycosyl hydrolase family 7 DHDPS PF00701.17 EFX05495.1 - 1.8e-37 128.5 0.0 2.5e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Transferase PF02458.10 EFX05496.1 - 1.1e-21 76.8 0.0 2e-19 69.3 0.0 2.3 2 1 0 2 2 2 2 Transferase family AMP-binding PF00501.23 EFX05497.1 - 1.8e-237 787.5 0.0 4e-84 282.4 0.0 3.9 4 0 0 4 4 4 3 AMP-binding enzyme Condensation PF00668.15 EFX05497.1 - 1.9e-163 542.4 0.0 3.1e-36 124.7 0.0 7.1 6 1 0 6 6 6 6 Condensation domain PP-binding PF00550.20 EFX05497.1 - 1.1e-38 131.3 9.4 7.9e-08 32.4 0.0 5.9 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EFX05497.1 - 7.5e-14 52.4 0.0 0.00043 21.1 0.0 4.1 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain WES_acyltransf PF03007.11 EFX05497.1 - 8.3e-05 22.2 0.6 2.2 7.7 0.0 4.5 5 0 0 5 5 5 2 Wax ester synthase-like Acyl-CoA acyltransferase domain Transferase PF02458.10 EFX05497.1 - 8.8e-05 21.1 0.2 1.6 7.1 0.0 3.5 3 0 0 3 3 3 2 Transferase family DUF229 PF02995.12 EFX05497.1 - 5.4 5.3 0.0 9.1 4.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Oligomerisation PF02410.10 EFX05498.1 - 0.00049 20.0 0.0 0.0091 16.0 0.0 2.4 1 1 0 1 1 1 1 Oligomerisation domain HTH_23 PF13384.1 EFX05498.1 - 0.029 14.0 1.2 5.3 6.8 0.1 2.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.1 EFX05498.1 - 0.088 12.0 2.3 5.2 6.3 0.3 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Rep_fac_C PF08542.6 EFX05499.1 - 2.9e-19 68.8 0.0 5.8e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EFX05499.1 - 2.8e-12 46.6 0.0 2.5e-10 40.2 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 EFX05499.1 - 4.4e-12 46.3 0.0 8.6e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFX05499.1 - 2.6e-07 30.6 0.0 4.4e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX05499.1 - 1.3e-06 28.5 0.1 0.00012 22.1 0.0 2.8 1 1 2 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 EFX05499.1 - 1.3e-05 24.4 0.0 3.4e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EFX05499.1 - 1.5e-05 25.1 0.1 0.0034 17.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.10 EFX05499.1 - 2.3e-05 23.3 0.0 0.018 13.7 0.0 2.9 2 1 1 3 3 3 1 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 EFX05499.1 - 5.3e-05 22.8 0.0 8.1e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.6 EFX05499.1 - 0.00016 21.2 0.0 0.00036 20.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 EFX05499.1 - 0.00031 20.2 0.1 0.054 12.9 0.0 2.3 1 1 1 2 2 2 1 AAA-like domain Mg_chelatase PF01078.16 EFX05499.1 - 0.0021 17.2 0.0 0.026 13.6 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI DNA_pol3_delta PF06144.8 EFX05499.1 - 0.0024 17.4 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_19 PF13245.1 EFX05499.1 - 0.0038 16.9 0.0 0.009 15.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 EFX05499.1 - 0.0039 16.6 0.1 0.07 12.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.10 EFX05499.1 - 0.0057 16.3 0.3 0.03 14.0 0.1 2.1 1 1 1 2 2 2 1 NTPase KTI12 PF08433.5 EFX05499.1 - 0.0083 15.3 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ArgK PF03308.11 EFX05499.1 - 0.0087 14.8 0.1 0.021 13.5 0.0 1.6 1 1 0 1 1 1 1 ArgK protein AAA_18 PF13238.1 EFX05499.1 - 0.0097 16.2 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EFX05499.1 - 0.011 15.4 0.0 0.044 13.5 0.0 2.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DEAD PF00270.24 EFX05499.1 - 0.013 14.9 0.1 0.22 11.0 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.1 EFX05499.1 - 0.022 14.3 0.0 0.034 13.7 0.0 1.3 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFX05499.1 - 0.027 13.9 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_31 PF13614.1 EFX05499.1 - 0.05 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFX05499.1 - 0.15 12.2 0.0 0.62 10.2 0.0 2.1 1 1 0 1 1 1 0 RNA helicase AAA_17 PF13207.1 EFX05499.1 - 0.21 12.4 0.5 0.56 11.0 0.4 1.9 1 1 0 1 1 1 0 AAA domain Mif2_N PF15624.1 EFX05500.1 - 3.2e-36 124.9 0.3 3.2e-36 124.9 0.2 3.0 3 0 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CENP-C_C PF11699.3 EFX05500.1 - 5.2e-32 109.6 0.1 7.7e-32 109.1 0.0 1.3 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.6 EFX05500.1 - 5.2e-07 29.0 0.0 1.1e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Adaptin_N PF01602.15 EFX05501.1 - 2.7e-100 336.1 0.0 3.2e-100 335.9 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 EFX05501.1 - 5.7e-10 39.3 7.1 5.5e-06 26.5 0.0 4.9 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.17 EFX05501.1 - 1.9e-08 33.6 0.9 0.24 11.5 0.0 5.5 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 EFX05501.1 - 6.4e-07 29.6 3.6 0.0014 19.0 0.0 5.3 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.2 EFX05501.1 - 0.012 15.4 0.0 0.07 12.9 0.0 2.2 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 VHS PF00790.14 EFX05501.1 - 0.012 15.2 0.1 2.9 7.5 0.0 3.0 4 0 0 4 4 4 0 VHS domain Cohesin_HEAT PF12765.2 EFX05501.1 - 0.049 13.5 0.3 2.7 8.0 0.0 3.0 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.3 EFX05501.1 - 0.079 12.2 0.1 3.6 6.8 0.0 3.0 2 1 1 3 3 3 0 CLASP N terminal DAO PF01266.19 EFX05502.1 - 1.4e-35 122.9 2.8 1.9e-35 122.4 1.9 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EFX05502.1 - 0.00052 20.1 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX05502.1 - 0.0025 17.8 0.5 0.0053 16.7 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EFX05502.1 - 0.0073 15.4 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family MFS_1 PF07690.11 EFX05503.1 - 4.9e-27 94.5 30.6 4.9e-27 94.5 21.2 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Far-17a_AIG1 PF04750.9 EFX05504.1 - 3e-55 186.5 7.7 3.4e-55 186.3 5.3 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF1356 PF07092.7 EFX05504.1 - 0.01 15.0 0.4 0.016 14.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) PGG PF13962.1 EFX05504.1 - 0.17 11.4 3.2 0.16 11.5 1.2 1.7 2 0 0 2 2 2 0 Domain of unknown function Fork_head PF00250.13 EFX05505.1 - 3.4e-34 116.7 0.4 6.7e-34 115.8 0.3 1.4 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EFX05505.1 - 7.6e-09 35.5 0.0 1.5e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Glyco_hydro_18 PF00704.23 EFX05506.1 - 4.1e-65 220.4 0.0 4.7e-65 220.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DHDPS PF00701.17 EFX05507.1 - 2.4e-43 147.7 0.0 2.9e-43 147.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family HTH_29 PF13551.1 EFX05507.1 - 0.01 15.9 0.0 0.046 13.8 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn helix PEP_mutase PF13714.1 EFX05507.1 - 0.022 13.9 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase COQ9 PF08511.6 EFX05507.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 COQ9 Hira PF07569.6 EFX05509.1 - 1.1e-78 263.4 0.0 3.5e-78 261.7 0.0 1.9 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.27 EFX05509.1 - 1.5e-41 138.8 23.3 4.5e-07 29.5 0.0 9.1 8 0 0 8 8 8 7 WD domain, G-beta repeat HIRA_B PF09453.5 EFX05509.1 - 3.9e-11 42.1 1.0 3.9e-11 42.1 0.7 2.0 2 0 0 2 2 2 1 HIRA B motif IKI3 PF04762.7 EFX05509.1 - 0.022 12.5 0.3 0.1 10.3 0.0 2.2 3 0 0 3 3 3 0 IKI3 family YmzC PF14157.1 EFX05509.1 - 0.19 11.5 0.0 0.59 10.0 0.0 1.8 1 0 0 1 1 1 0 YmzC-like protein Period_C PF12114.3 EFX05509.1 - 9.1 5.8 10.6 26 4.3 7.3 1.7 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Rhodanese PF00581.15 EFX05510.1 - 4.6e-14 52.7 0.0 5.5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Rcd1 PF04078.8 EFX05511.1 - 9.7e-132 437.6 3.5 1.1e-131 437.4 2.5 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Yip1 PF04893.12 EFX05512.1 - 3.7e-12 46.0 15.9 3.7e-12 46.0 11.1 1.4 1 1 0 1 1 1 1 Yip1 domain Fusion_gly_K PF01621.12 EFX05512.1 - 0.083 11.9 0.5 0.12 11.3 0.4 1.2 1 0 0 1 1 1 0 Cell fusion glycoprotein K Nuc_sug_transp PF04142.10 EFX05512.1 - 0.53 9.3 6.5 7 5.6 4.5 2.2 1 1 0 1 1 1 0 Nucleotide-sugar transporter Pyr_redox_3 PF13738.1 EFX05514.1 - 0.00027 21.0 0.0 0.00029 20.9 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AFG1_ATPase PF03969.11 EFX05517.1 - 1.4e-97 326.8 0.1 1.6e-92 310.1 0.0 2.6 2 1 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.13 EFX05517.1 - 6.2e-05 22.7 0.1 0.031 13.9 0.0 2.7 2 1 0 2 2 2 2 Bacterial dnaA protein AAA_16 PF13191.1 EFX05517.1 - 0.00026 21.0 2.6 0.1 12.5 0.0 3.5 3 2 0 4 4 4 2 AAA ATPase domain AAA PF00004.24 EFX05517.1 - 0.0059 16.8 0.0 0.026 14.7 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX05517.1 - 0.013 15.6 0.0 0.039 14.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EFX05517.1 - 0.021 14.5 0.1 0.14 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 EFX05517.1 - 0.029 14.4 0.0 0.24 11.4 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain UvrD-helicase PF00580.16 EFX05517.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain NACHT PF05729.7 EFX05517.1 - 0.077 12.6 0.0 0.43 10.2 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Filo_VP35 PF02097.10 EFX05517.1 - 0.12 11.5 0.1 0.53 9.4 0.0 1.9 2 0 0 2 2 2 0 Filoviridae VP35 Sec7_N PF12783.2 EFX05518.1 - 1.3e-32 112.5 0.0 1.3e-32 112.5 0.0 2.7 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 EFX05518.1 - 0.00014 21.2 1.6 0.017 14.5 0.0 4.2 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) HSF_DNA-bind PF00447.12 EFX05519.1 - 1.1e-35 121.8 0.4 1.7e-35 121.2 0.3 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding PLDc_2 PF13091.1 EFX05520.1 - 3.5e-16 59.0 0.0 5.7e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain Regulator_TrmB PF11495.3 EFX05520.1 - 0.024 13.6 0.0 5.7 5.8 0.0 2.6 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB PLDc PF00614.17 EFX05520.1 - 0.085 12.6 0.5 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Phospholipase D Active site motif FMN_red PF03358.10 EFX05521.1 - 7.7e-08 31.9 0.2 1.7e-07 30.8 0.0 1.6 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 EFX05521.1 - 2.1e-07 31.0 0.2 5.4e-07 29.6 0.2 1.8 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.12 EFX05521.1 - 2.5e-05 23.8 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_4 PF12682.2 EFX05521.1 - 0.08 12.2 0.1 0.25 10.7 0.1 1.8 1 1 0 1 1 1 0 Flavodoxin MutS_V PF00488.16 EFX05522.1 - 5.2e-80 268.2 0.0 9.5e-80 267.3 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EFX05522.1 - 4.8e-50 170.1 0.3 9.2e-50 169.2 0.2 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EFX05522.1 - 2.2e-33 114.6 0.1 9e-33 112.6 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.12 EFX05522.1 - 9.4e-14 51.6 0.0 4.2e-13 49.5 0.0 2.1 1 1 0 1 1 1 1 MutS domain II MutS_IV PF05190.13 EFX05522.1 - 1.2e-11 44.5 0.0 2.9e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.1 EFX05522.1 - 0.014 14.9 0.0 0.036 13.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EFX05522.1 - 0.021 15.1 0.1 0.055 13.7 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 EFX05522.1 - 0.17 11.8 1.0 0.37 10.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 EFX05523.1 - 9.4e-46 155.3 0.0 2.4e-45 154.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX05523.1 - 1.2e-20 73.1 0.1 7.1e-20 70.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 EFX05523.1 - 1.7e-19 69.3 4.3 3.4e-18 65.2 3.0 2.5 1 1 0 1 1 1 1 DBP10CT (NUC160) domain SLY PF12485.3 EFX05523.1 - 0.0002 21.6 1.8 0.00049 20.3 1.3 1.7 1 0 0 1 1 1 1 Lymphocyte signaling adaptor protein ResIII PF04851.10 EFX05523.1 - 0.0019 18.0 0.0 0.0068 16.2 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFX05523.1 - 0.011 14.5 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain GRASP55_65 PF04495.9 EFX05524.1 - 1.6e-47 160.9 0.0 3e-46 156.8 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PALP PF00291.20 EFX05525.1 - 3.4e-60 203.8 5.9 6.3e-59 199.6 4.1 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 EFX05525.1 - 2.9e-38 129.3 0.0 4.9e-20 70.9 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Transp_cyt_pur PF02133.10 EFX05526.1 - 6.5e-134 446.8 43.8 8.2e-132 439.8 30.3 2.1 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MARVEL PF01284.18 EFX05527.1 - 0.005 16.6 15.2 0.024 14.4 7.0 2.1 1 1 1 2 2 2 2 Membrane-associating domain GRA6 PF05084.8 EFX05527.1 - 0.6 9.6 2.3 3.6 7.0 0.0 2.2 1 1 1 2 2 2 0 Granule antigen protein (GRA6) LMBR1 PF04791.11 EFX05527.1 - 2.5 6.5 6.4 1.2 7.6 2.5 1.6 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4234 PF14018.1 EFX05527.1 - 3.5 7.4 5.4 7.1 6.4 3.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) adh_short PF00106.20 EFX05528.1 - 1.2e-27 96.9 11.0 1.4e-27 96.6 7.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX05528.1 - 3e-22 79.5 3.0 3.7e-22 79.2 2.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX05528.1 - 5.1e-11 42.5 6.5 7.3e-11 42.0 4.5 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 EFX05528.1 - 0.057 12.5 0.2 0.13 11.3 0.1 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 EFX05528.1 - 8.4 6.2 8.1 0.69 9.7 1.1 2.5 3 1 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CoA_binding_2 PF13380.1 EFX05531.1 - 6e-25 87.6 0.1 8e-25 87.2 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain DUF1425 PF07233.7 EFX05531.1 - 0.037 13.5 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1425) NUC153 PF08159.7 EFX05532.1 - 1.2e-10 40.7 0.7 1.2e-10 40.7 0.5 3.1 3 0 0 3 3 3 2 NUC153 domain EF-hand_7 PF13499.1 EFX05533.1 - 2.9e-15 56.1 0.4 1.3e-09 38.0 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EFX05533.1 - 8.9e-12 43.8 0.4 5.9e-05 22.6 0.0 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.1 EFX05533.1 - 2.5e-10 40.1 0.0 0.00016 21.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 EFX05533.1 - 4.3e-10 38.1 0.2 0.00081 18.5 0.0 3.7 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 EFX05533.1 - 2.6e-09 36.5 0.7 0.0012 18.3 0.0 3.6 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 EFX05533.1 - 0.096 12.0 0.7 5.9 6.4 0.1 2.7 2 0 0 2 2 2 0 EF hand Acyl_transf_1 PF00698.16 EFX05534.1 - 2.2e-22 79.8 0.1 4.8e-22 78.6 0.0 1.5 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.1 EFX05534.1 - 7.8e-17 61.3 0.1 2e-16 60.0 0.0 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.7 EFX05534.1 - 9.1e-15 54.9 0.1 5.2e-14 52.5 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Abhydrolase_5 PF12695.2 EFX05534.1 - 3.8e-12 46.1 0.0 7.1e-10 38.8 0.0 4.0 4 1 0 4 4 4 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFX05534.1 - 5.8e-12 45.6 0.0 3.2e-11 43.2 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold PP-binding PF00550.20 EFX05534.1 - 1.1e-11 44.8 2.3 2.6e-11 43.5 1.6 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.2 EFX05534.1 - 1.4e-11 44.7 4.0 1.6e-10 41.2 0.5 3.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family Methyltransf_23 PF13489.1 EFX05534.1 - 9.7e-10 38.4 0.0 1.7e-08 34.3 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05534.1 - 5.5e-09 35.7 0.0 1.7e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Peptidase_S9 PF00326.16 EFX05534.1 - 1.6e-08 34.0 0.0 1.6e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Methyltransf_18 PF12847.2 EFX05534.1 - 1.6e-05 25.4 0.1 5.6e-05 23.6 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05534.1 - 2.1e-05 24.9 0.0 6.3e-05 23.3 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05534.1 - 0.00068 19.6 0.0 0.0021 18.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX05534.1 - 0.0073 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EFX05534.1 - 0.022 15.1 0.0 0.064 13.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_28 PF02636.12 EFX05534.1 - 0.062 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF938 PF06080.7 EFX05534.1 - 0.065 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.13 EFX05534.1 - 0.072 12.1 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Abhydrolase_2 PF02230.11 EFX05534.1 - 0.087 12.2 0.0 3.7 6.9 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PARP_regulatory PF01358.13 EFX05534.1 - 0.2 10.2 0.0 0.34 9.5 0.0 1.2 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit AA_permease PF00324.16 EFX05535.1 - 2.3e-124 415.3 38.2 2.9e-124 415.0 26.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX05535.1 - 1.6e-40 138.9 37.0 2e-40 138.6 25.7 1.0 1 0 0 1 1 1 1 Amino acid permease Trm112p PF03966.11 EFX05536.1 - 4.4e-13 49.3 0.1 5.4e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.1 EFX05536.1 - 0.025 14.8 0.3 0.044 14.0 0.2 1.4 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain FGGY_C PF02782.11 EFX05538.1 - 1.1e-25 90.4 0.0 3.4e-25 88.8 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EFX05538.1 - 6.5e-17 61.6 0.0 2.7e-11 43.2 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Glyco_hydro_76 PF03663.9 EFX05539.1 - 2.7e-121 405.4 12.0 3.5e-121 405.0 8.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 PIG-P PF08510.7 EFX05541.1 - 5.7e-39 132.6 0.4 1.2e-33 115.4 1.2 2.3 2 0 0 2 2 2 2 PIG-P CDC45 PF02724.9 EFX05541.1 - 8.1e-05 20.8 0.1 8.1e-05 20.8 0.1 1.4 2 0 0 2 2 2 1 CDC45-like protein Cwf_Cwc_15 PF04889.7 EFX05541.1 - 0.2 11.3 10.2 0.41 10.3 7.1 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein MORN PF02493.15 EFX05541.1 - 0.23 11.2 3.5 3.7 7.4 0.1 2.8 2 0 0 2 2 2 0 MORN repeat DUF605 PF04652.11 EFX05541.1 - 1.1 8.5 8.0 0.1 11.9 1.9 1.7 2 0 0 2 2 2 0 Vta1 like PPP4R2 PF09184.6 EFX05541.1 - 2.4 7.6 13.6 3.6 7.0 9.4 1.3 1 0 0 1 1 1 0 PPP4R2 YL1 PF05764.8 EFX05541.1 - 2.6 7.5 9.4 4.8 6.7 6.5 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.7 EFX05541.1 - 5.2 4.8 22.6 7.4 4.3 15.7 1.1 1 0 0 1 1 1 0 Nop14-like family DPM2 PF07297.7 EFX05541.1 - 6.1 7.2 7.8 10 6.4 5.4 1.2 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Bestrophin PF01062.16 EFX05542.1 - 5.3e-47 160.1 0.1 7.8e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF2867 PF11066.3 EFX05542.1 - 0.16 11.7 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) Lipase_GDSL_2 PF13472.1 EFX05543.1 - 2.6e-14 53.7 0.5 3.5e-12 46.8 0.1 2.4 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFX05543.1 - 1.9e-09 37.7 0.8 2.4e-07 30.8 0.2 2.4 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase SBF PF01758.11 EFX05544.1 - 2e-30 105.6 16.3 1.8e-22 79.6 4.4 2.7 2 2 1 3 3 3 2 Sodium Bile acid symporter family zf-H2C2_2 PF13465.1 EFX05546.1 - 3.7e-07 30.0 11.3 5.3e-06 26.4 0.8 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EFX05546.1 - 6.6e-06 26.0 14.2 0.00063 19.8 4.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 EFX05546.1 - 0.00081 19.4 4.7 0.0018 18.3 3.3 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EFX05546.1 - 0.0031 17.7 16.8 0.021 15.1 4.7 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_Tnp_IS1595 PF12760.2 EFX05546.1 - 0.31 10.8 1.7 0.57 10.0 1.2 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-BED PF02892.10 EFX05546.1 - 0.8 9.5 8.6 0.76 9.5 1.2 2.7 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.3 EFX05546.1 - 1.3 9.2 9.6 3.4 7.9 0.5 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AMP-binding PF00501.23 EFX05547.1 - 1.7e-75 254.0 0.1 2.9e-75 253.2 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 EFX05547.1 - 1.2e-64 217.6 0.2 1.3e-63 214.2 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein adh_short PF00106.20 EFX05547.1 - 6.2e-31 107.5 17.5 4.3e-29 101.5 6.8 3.2 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 EFX05547.1 - 3.9e-18 66.1 0.8 7.2e-18 65.2 0.5 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EFX05547.1 - 1.9e-17 63.4 2.0 3.8e-12 46.1 0.0 2.8 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family KR PF08659.5 EFX05547.1 - 3.9e-17 62.5 11.9 8.2e-14 51.6 5.6 2.5 2 0 0 2 2 2 2 KR domain PP-binding PF00550.20 EFX05547.1 - 1.2e-10 41.4 0.0 3.3e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.14 EFX05547.1 - 6e-09 35.0 0.1 8.1e-05 21.4 0.0 2.5 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.1 EFX05547.1 - 8.8e-08 32.9 0.4 4.1e-07 30.8 0.3 2.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.1 EFX05547.1 - 1.5e-06 28.3 8.7 0.0014 18.6 3.1 3.5 2 2 0 2 2 2 2 NADH(P)-binding Polysacc_synt_2 PF02719.10 EFX05547.1 - 0.001 18.0 2.1 0.087 11.7 0.4 2.6 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NmrA PF05368.8 EFX05547.1 - 0.0014 17.9 4.0 1.4 8.0 0.0 3.1 3 0 0 3 3 3 2 NmrA-like family THF_DHG_CYH_C PF02882.14 EFX05547.1 - 0.0069 15.4 0.3 0.016 14.2 0.2 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.3 EFX05547.1 - 0.011 15.4 1.0 0.058 13.1 0.7 2.3 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase HNOB PF07700.10 EFX05547.1 - 0.61 9.5 0.0 1.1 8.8 0.0 1.3 1 0 0 1 1 1 0 Heme NO binding ADH_zinc_N_2 PF13602.1 EFX05548.1 - 1.6e-17 64.5 0.1 3.4e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EFX05548.1 - 2.4e-13 49.7 0.2 5.5e-13 48.5 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aminotran_1_2 PF00155.16 EFX05549.1 - 1.1e-34 120.0 0.0 1.2e-34 119.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Sec7 PF01369.15 EFX05550.1 - 6.8e-43 146.5 0.0 1.4e-42 145.4 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 EFX05550.1 - 1e-16 61.1 0.0 3.1e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain GN3L_Grn1 PF08701.6 EFX05550.1 - 0.55 10.1 5.0 1.3 8.9 3.5 1.6 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase BAF1_ABF1 PF04684.8 EFX05550.1 - 4.4 6.0 12.9 9.1 4.9 8.9 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3591 PF12157.3 EFX05551.1 - 8.1e-178 591.5 0.4 1.1e-177 591.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.1 EFX05551.1 - 0.01 15.4 1.5 0.029 14.0 1.1 1.8 1 0 0 1 1 1 0 Zinc knuckle Aldedh PF00171.17 EFX05552.1 - 1e-131 439.4 0.2 1.2e-131 439.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ApbA PF02558.11 EFX05553.1 - 2.5e-28 98.4 0.0 5.4e-28 97.3 0.0 1.5 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 EFX05553.1 - 7.6e-24 84.0 0.0 1.5e-23 83.1 0.0 1.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ABC_tran PF00005.22 EFX05555.1 - 8.4e-33 113.5 0.0 1.9e-32 112.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EFX05555.1 - 1.3e-32 113.3 11.4 1.7e-32 112.9 7.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.1 EFX05555.1 - 1.2e-07 31.9 0.0 0.0026 17.7 0.0 2.5 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 EFX05555.1 - 1.9e-05 24.7 0.2 0.00014 21.9 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 EFX05555.1 - 3.9e-05 22.9 0.0 0.012 14.8 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EFX05555.1 - 8.6e-05 23.3 0.0 0.00021 22.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX05555.1 - 0.00032 20.8 0.0 0.0024 18.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFX05555.1 - 0.0015 17.7 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 EFX05555.1 - 0.0025 17.7 0.0 0.013 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFX05555.1 - 0.0037 16.7 0.1 0.013 14.9 0.0 2.0 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 EFX05555.1 - 0.015 15.5 0.0 0.048 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFX05555.1 - 0.019 14.9 0.0 0.078 12.9 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_10 PF12846.2 EFX05555.1 - 0.021 14.2 0.0 0.05 13.0 0.0 1.6 2 0 0 2 2 1 0 AAA-like domain AAA_33 PF13671.1 EFX05555.1 - 0.035 13.9 0.0 0.098 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EFX05555.1 - 0.038 13.7 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 EFX05555.1 - 0.043 13.2 0.4 0.16 11.3 0.3 2.1 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 EFX05555.1 - 0.046 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase SbcCD_C PF13558.1 EFX05555.1 - 0.063 13.2 0.4 0.59 10.0 0.3 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATP-synt_ab PF00006.20 EFX05555.1 - 0.096 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.7 EFX05555.1 - 0.11 12.1 0.1 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Rad17 PF03215.10 EFX05555.1 - 0.28 9.8 0.0 0.43 9.2 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_23 PF13476.1 EFX05555.1 - 0.37 11.0 0.0 0.67 10.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mre11_DNA_bind PF04152.9 EFX05556.1 - 3.8e-53 179.9 0.1 9.2e-53 178.6 0.1 1.7 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 EFX05556.1 - 3.2e-22 78.9 3.0 5.8e-22 78.0 2.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SWIRM PF04433.12 EFX05556.1 - 1.5e-13 50.6 0.0 3.7e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 EFX05556.1 - 1.7e-06 27.9 0.0 4.8e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain CagZ PF09053.5 EFX05556.1 - 0.043 13.1 0.0 0.49 9.6 0.0 2.3 2 0 0 2 2 2 0 CagZ Glyco_hydro_18 PF00704.23 EFX05557.1 - 2.6e-49 168.5 0.1 3.1e-49 168.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF2796 PF10986.3 EFX05557.1 - 0.31 10.9 9.2 0.67 9.9 6.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2796) GDA1_CD39 PF01150.12 EFX05558.1 - 6.6e-97 324.7 0.0 8.6e-97 324.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family IF4E PF01652.13 EFX05560.1 - 9.5e-36 122.8 0.0 1.2e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RRN3 PF05327.6 EFX05561.1 - 3.8e-148 494.0 0.0 7.7e-148 493.0 0.0 1.4 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Ppx-GppA PF02541.11 EFX05562.1 - 3.7e-30 105.1 0.0 5.4e-28 97.9 0.0 2.1 1 1 0 1 1 1 1 Ppx/GppA phosphatase family EutA PF06277.6 EFX05562.1 - 0.013 14.1 0.3 0.02 13.4 0.2 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA StbA PF06406.6 EFX05562.1 - 0.046 12.6 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 StbA protein WD40 PF00400.27 EFX05565.1 - 7.7e-06 25.5 2.0 0.00029 20.5 0.1 3.9 4 0 0 4 4 4 1 WD domain, G-beta repeat TFIIA PF03153.8 EFX05565.1 - 0.0013 18.7 3.2 0.0013 18.7 2.2 1.6 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit TRAP_alpha PF03896.11 EFX05565.1 - 0.51 9.2 11.6 1 8.2 8.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.7 EFX05565.1 - 1.5 6.6 12.4 2.5 5.9 8.6 1.2 1 0 0 1 1 1 0 Nop14-like family PQ-loop PF04193.9 EFX05566.1 - 1.4e-40 136.5 8.6 2.1e-20 72.0 1.3 2.8 2 0 0 2 2 2 2 PQ loop repeat HemX PF04375.9 EFX05566.1 - 0.03 12.9 0.7 0.041 12.4 0.5 1.1 1 0 0 1 1 1 0 HemX LRS4 PF10422.4 EFX05566.1 - 0.48 9.7 4.5 0.96 8.7 3.1 1.4 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 IBR PF01485.16 EFX05567.1 - 3.3e-20 71.7 36.4 5.5e-13 48.5 1.9 4.2 3 1 1 4 4 4 2 IBR domain RWD PF05773.17 EFX05567.1 - 2e-17 63.0 0.0 4e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.1 EFX05567.1 - 1.5e-05 24.7 7.6 1.5e-05 24.7 5.3 3.5 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 EFX05567.1 - 0.0024 17.8 8.4 0.0024 17.8 5.8 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX05567.1 - 0.012 15.2 7.1 0.012 15.2 4.9 4.1 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFX05567.1 - 0.015 15.1 0.4 0.015 15.1 0.3 4.3 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING DUF1633 PF07794.6 EFX05567.1 - 0.023 12.6 3.0 0.032 12.1 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Mob_synth_C PF06463.8 EFX05567.1 - 0.044 13.4 0.5 0.1 12.2 0.3 1.6 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C API5 PF05918.6 EFX05567.1 - 9.3 4.6 9.3 14 4.0 6.5 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) zf-RING_UBOX PF13445.1 EFX05567.1 - 9.8 5.9 14.4 0.13 11.9 2.4 2.6 2 0 0 2 2 2 0 RING-type zinc-finger NAD_binding_8 PF13450.1 EFX05568.1 - 5.4e-11 42.3 0.2 1.3e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX05568.1 - 5.9e-09 35.2 0.1 1.2e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 EFX05568.1 - 6.2e-09 35.4 0.2 1.2e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.2 EFX05568.1 - 6.6e-08 32.0 0.8 1.1e-07 31.3 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EFX05568.1 - 1.8e-06 27.0 0.4 3.7e-06 26.0 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EFX05568.1 - 2.3e-06 26.8 0.3 4.7e-06 25.8 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 EFX05568.1 - 4.9e-06 26.7 0.1 0.00016 21.7 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX05568.1 - 4.1e-05 23.5 0.3 9.8e-05 22.3 0.1 1.7 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX05568.1 - 8.1e-05 21.6 0.1 0.00012 21.0 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 EFX05568.1 - 8.6e-05 21.7 1.0 0.00018 20.7 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EFX05568.1 - 9.4e-05 21.0 0.7 0.00014 20.4 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EFX05568.1 - 0.0011 19.3 0.1 0.003 17.9 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX05568.1 - 0.0011 17.6 0.3 0.002 16.8 0.2 1.3 1 0 0 1 1 1 1 Tryptophan halogenase IlvN PF07991.7 EFX05568.1 - 0.0015 17.8 0.1 0.0027 17.0 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Lycopene_cycl PF05834.7 EFX05568.1 - 0.0023 16.9 0.2 0.0037 16.2 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_7 PF13241.1 EFX05568.1 - 0.017 15.3 0.0 0.041 14.1 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 EFX05568.1 - 0.038 13.5 0.2 0.15 11.5 0.1 2.0 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.1 EFX05568.1 - 0.077 12.7 0.5 0.16 11.7 0.1 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding zf-C2H2_4 PF13894.1 EFX05569.1 - 0.0051 17.0 1.5 0.14 12.5 0.1 2.9 2 1 1 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX05569.1 - 0.12 12.7 0.9 11 6.5 0.1 3.0 2 1 1 3 3 3 0 Zinc finger, C2H2 type Pkinase PF00069.20 EFX05570.1 - 7.9e-06 25.1 0.0 3.6e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain DIOX_N PF14226.1 EFX05571.1 - 4.5e-20 72.3 0.0 2e-19 70.2 0.0 2.1 3 0 0 3 3 3 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX05571.1 - 8e-12 45.3 0.0 1.4e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CcmD PF04995.9 EFX05572.1 - 2.8 7.7 4.7 0.38 10.5 0.3 1.7 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DUF3419 PF11899.3 EFX05573.1 - 9.4e-142 472.2 0.0 1.2e-141 471.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.1 EFX05573.1 - 3.9e-13 49.4 0.0 3.5e-12 46.3 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05573.1 - 3.2e-09 37.1 0.0 1.7e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05573.1 - 1.2e-08 35.5 0.0 5.2e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05573.1 - 2.5e-08 33.9 3.9 6.5e-07 29.4 0.0 3.5 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05573.1 - 2.7e-07 30.3 0.0 1.1e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05573.1 - 6.6e-06 26.5 0.0 0.0029 18.0 0.0 3.4 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX05573.1 - 0.00017 20.7 0.0 0.018 14.1 0.0 2.3 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.14 EFX05573.1 - 0.0035 16.9 0.0 0.0059 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 EFX05573.1 - 0.16 10.9 0.0 0.34 9.9 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Zn_clus PF00172.13 EFX05575.1 - 0.00019 21.2 11.7 0.00035 20.4 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CPSF100_C PF13299.1 EFX05575.1 - 0.42 10.7 3.2 1 9.5 2.2 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Cornichon PF03311.9 EFX05576.1 - 1.8e-54 183.2 10.9 2e-54 183.1 7.5 1.0 1 0 0 1 1 1 1 Cornichon protein Rieske PF00355.21 EFX05577.1 - 7.1e-18 63.9 0.0 1.2e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.9 EFX05577.1 - 1.9e-17 63.2 0.8 5e-17 61.8 0.5 1.7 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region tRNA_bind PF01588.15 EFX05578.1 - 2.2e-22 78.6 0.1 2.2e-21 75.4 0.1 2.3 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 EFX05578.1 - 3.7e-05 24.1 0.0 0.0001 22.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFX05578.1 - 0.0076 16.1 0.1 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EFX05578.1 - 0.18 11.8 2.1 0.28 11.1 0.0 2.3 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Usp PF00582.21 EFX05578.1 - 8.1 6.6 8.7 2 8.5 2.1 2.5 3 0 0 3 3 3 0 Universal stress protein family Ribosomal_L12 PF00542.14 EFX05579.1 - 2e-19 69.3 5.6 2.4e-19 69.0 2.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain PP2C_C PF07830.8 EFX05579.1 - 0.0085 16.1 1.0 0.074 13.1 0.0 2.4 2 1 0 2 2 2 1 Protein serine/threonine phosphatase 2C, C-terminal domain ROS_MUCR PF05443.6 EFX05579.1 - 0.054 13.2 1.2 0.34 10.6 0.0 2.3 1 1 2 3 3 3 0 ROS/MUCR transcriptional regulator protein EIIBC-GUT_N PF03612.9 EFX05579.1 - 0.096 12.2 0.0 0.46 10.0 0.0 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Na_Ca_ex PF01699.19 EFX05581.1 - 7.8e-27 93.5 20.7 1.2e-15 57.3 3.1 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF202 PF02656.10 EFX05581.1 - 3.7 7.8 12.0 5.7 7.2 0.3 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF202) AA_kinase PF00696.23 EFX05582.1 - 1.2e-34 119.9 0.0 1.6e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family Sda PF08970.5 EFX05582.1 - 0.023 14.1 0.0 0.053 13.0 0.0 1.6 1 0 0 1 1 1 0 Sporulation inhibitor A Cyclin_C PF02984.14 EFX05583.1 - 2.9 7.8 4.6 4.4 7.2 0.1 2.9 3 1 1 4 4 4 0 Cyclin, C-terminal domain TPR_11 PF13414.1 EFX05584.1 - 1.2e-08 34.4 10.5 0.0085 15.7 0.1 3.5 3 0 0 3 3 3 3 TPR repeat TPR_1 PF00515.23 EFX05584.1 - 2.6e-05 23.6 7.6 0.13 11.8 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX05584.1 - 0.00038 20.8 1.6 0.00038 20.8 1.1 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 EFX05584.1 - 0.0015 18.3 11.2 0.0084 15.9 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX05584.1 - 0.0023 18.5 1.8 0.0023 18.5 1.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX05584.1 - 0.0032 17.7 1.0 0.013 15.7 0.7 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat FmdA_AmdA PF03069.10 EFX05585.1 - 8.1e-150 498.5 0.0 1e-149 498.2 0.0 1.1 1 0 0 1 1 1 1 Acetamidase/Formamidase family EI24 PF07264.6 EFX05585.1 - 9.8e-07 28.4 9.7 4.8e-06 26.1 6.7 2.0 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-H2C2_2 PF13465.1 EFX05586.1 - 2.9e-09 36.7 22.3 2.8e-06 27.3 2.0 4.5 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 EFX05586.1 - 4e-05 23.6 13.6 0.0014 18.8 2.9 4.3 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX05586.1 - 0.0067 16.6 1.5 0.0067 16.6 1.0 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger Macoilin PF09726.4 EFX05586.1 - 2.9 6.0 13.0 4.5 5.4 9.0 1.3 1 0 0 1 1 1 0 Transmembrane protein F-box PF00646.28 EFX05587.1 - 0.00044 19.8 0.0 0.0014 18.2 0.0 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EFX05587.1 - 0.0036 17.0 1.3 0.0062 16.2 0.0 2.1 2 0 0 2 2 2 1 F-box-like TRP PF06011.7 EFX05588.1 - 3.3e-128 427.9 13.1 5.4e-128 427.2 9.1 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EFX05588.1 - 2.6e-36 124.7 4.6 4.9e-36 123.8 3.2 1.5 1 0 0 1 1 1 1 ML-like domain Mit_ribos_Mrp51 PF11709.3 EFX05589.1 - 4.7e-79 265.8 0.2 5.9e-79 265.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit NAD_binding_11 PF14833.1 EFX05591.1 - 2e-62 208.6 1.5 2.9e-30 104.8 0.0 2.5 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.10 EFX05591.1 - 8.1e-52 175.3 2.6 6e-35 120.4 0.4 3.1 3 0 0 3 3 3 2 NAD binding domain of 6-phosphogluconate dehydrogenase DUF1537 PF07005.6 EFX05591.1 - 5e-20 72.1 1.8 5e-20 72.1 1.2 2.9 3 0 0 3 3 3 1 Protein of unknown function, DUF1537 F420_oxidored PF03807.12 EFX05591.1 - 2.5e-10 40.6 0.4 7.1e-06 26.3 0.1 3.4 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 EFX05591.1 - 3.1e-05 23.2 0.0 0.016 14.3 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 EFX05591.1 - 7.5e-05 22.4 3.6 0.00011 21.9 0.4 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 EFX05591.1 - 0.00045 19.6 4.9 0.43 9.9 0.1 4.4 4 1 1 5 5 5 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 EFX05591.1 - 0.00078 19.4 0.1 1.6 8.7 0.0 3.0 2 0 0 2 2 2 2 TrkA-N domain ApbA PF02558.11 EFX05591.1 - 0.89 8.9 7.1 0.29 10.5 1.3 2.6 2 1 1 3 3 3 0 Ketopantoate reductase PanE/ApbA bZIP_1 PF00170.16 EFX05593.1 - 8.2e-05 22.4 7.4 0.00013 21.8 5.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX05593.1 - 0.0036 17.0 8.2 0.0057 16.4 5.7 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EFX05593.1 - 0.1 12.8 3.0 0.17 12.1 2.0 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Chorion_2 PF03964.10 EFX05593.1 - 4.1 7.9 9.3 0.74 10.3 2.5 2.6 2 1 0 2 2 2 0 Chorion family 2 CHGN PF05679.11 EFX05594.1 - 0.16 10.6 0.0 0.21 10.2 0.0 1.1 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase PTPA PF03095.10 EFX05595.1 - 1.9e-99 332.6 0.0 1.5e-98 329.7 0.0 1.9 1 1 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Zip PF02535.17 EFX05595.1 - 0.091 11.7 10.1 0.16 10.9 7.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Sporozoite_P67 PF05642.6 EFX05595.1 - 0.43 8.3 6.6 8 4.1 5.0 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen SelP_N PF04592.9 EFX05595.1 - 9.2 5.5 16.5 16 4.7 11.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MMS1_N PF10433.4 EFX05596.1 - 2.4e-87 293.2 0.0 3.8e-87 292.5 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Glyco_hydro_76 PF03663.9 EFX05597.1 - 1.5e-41 143.0 1.2 1.5e-41 143.0 0.8 2.0 1 1 0 2 2 2 2 Glycosyl hydrolase family 76 Reprolysin_4 PF13583.1 EFX05598.1 - 0.00048 19.7 0.1 0.00081 18.9 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 EFX05598.1 - 0.00061 20.3 0.1 0.0013 19.2 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 EFX05598.1 - 0.0013 18.7 0.1 0.0033 17.5 0.0 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EFX05598.1 - 0.0017 18.2 0.1 0.0029 17.5 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Astacin PF01400.19 EFX05598.1 - 0.003 16.9 0.7 0.17 11.2 0.3 3.0 3 0 0 3 3 3 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.19 EFX05598.1 - 0.034 13.8 0.0 0.065 12.9 0.0 1.6 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.4 EFX05598.1 - 0.076 11.8 0.2 0.12 11.2 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 Acetyltransf_3 PF13302.1 EFX05599.1 - 4.4e-21 75.5 0.0 5.1e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX05599.1 - 1.8e-07 31.0 0.0 2.2e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 EFX05599.1 - 1.3e-05 25.1 0.0 2.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EFX05599.1 - 9e-05 22.5 0.0 0.00038 20.5 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX05599.1 - 0.00013 21.6 0.0 0.0057 16.3 0.0 2.3 2 0 0 2 2 2 1 FR47-like protein adh_short PF00106.20 EFX05600.1 - 1.2e-23 83.8 6.0 2.2e-23 83.0 4.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX05600.1 - 1.7e-12 47.3 4.5 2.2e-11 43.7 3.1 2.3 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EFX05600.1 - 1.1e-09 38.3 0.0 1.9e-09 37.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EFX05600.1 - 0.00012 22.1 1.4 0.00022 21.2 0.5 1.7 2 0 0 2 2 2 1 NADH(P)-binding TrkA_N PF02254.13 EFX05600.1 - 0.045 13.7 0.1 0.11 12.5 0.1 1.6 2 0 0 2 2 2 0 TrkA-N domain Epimerase PF01370.16 EFX05600.1 - 0.083 12.3 0.2 0.19 11.1 0.1 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family HI0933_like PF03486.9 EFX05600.1 - 0.11 10.9 0.2 0.15 10.5 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Hydrolase_4 PF12146.3 EFX05601.1 - 0.0012 18.6 0.0 0.0036 17.1 0.0 1.7 2 0 0 2 2 2 1 Putative lysophospholipase WD40 PF00400.27 EFX05602.1 - 8.3e-18 63.5 19.0 0.00027 20.6 0.0 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 EFX05602.1 - 0.0098 14.0 5.8 0.36 8.9 0.0 3.8 3 1 1 4 4 4 2 Nucleoporin Nup120/160 DUF2376 PF09550.5 EFX05602.1 - 0.7 10.0 0.1 0.7 10.0 0.1 3.1 3 0 0 3 3 3 0 Conserved hypothetical phage protein (DUF2376) SH3_9 PF14604.1 EFX05603.1 - 3.9e-09 35.9 0.1 2.6e-06 26.9 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.12 EFX05603.1 - 0.0038 16.6 0.0 0.013 14.9 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain zf-C2H2_4 PF13894.1 EFX05603.1 - 0.29 11.5 1.0 1.6 9.2 0.0 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger SAC3_GANP PF03399.11 EFX05604.1 - 6.3e-65 218.5 0.1 8.7e-65 218.1 0.1 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EFX05604.1 - 0.043 13.5 0.0 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 Bap31 PF05529.7 EFX05605.1 - 7.3e-62 208.2 2.4 8.4e-62 208.0 1.7 1.0 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like Filament PF00038.16 EFX05605.1 - 0.00019 21.0 0.2 0.00027 20.5 0.1 1.2 1 0 0 1 1 1 1 Intermediate filament protein Rab5-bind PF09311.6 EFX05605.1 - 0.022 14.6 0.9 0.21 11.4 0.6 2.1 1 1 1 2 2 2 0 Rabaptin-like protein Spc7 PF08317.6 EFX05605.1 - 0.027 13.1 0.4 0.036 12.7 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.7 EFX05605.1 - 0.056 13.1 1.1 0.09 12.5 0.8 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Spc24 PF08286.6 EFX05605.1 - 0.1 12.3 0.2 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.15 EFX05605.1 - 0.18 11.5 2.4 0.25 11.1 0.8 1.8 2 0 0 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.3 EFX05605.1 - 0.27 11.0 5.2 0.33 10.7 3.1 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 EFX05605.1 - 3 7.4 9.1 1.2 8.6 1.2 3.1 3 1 1 4 4 4 0 Septum formation initiator Coq4 PF05019.8 EFX05606.1 - 5.6e-87 290.3 0.0 6.5e-87 290.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 HSP70 PF00012.15 EFX05607.1 - 6.3e-162 539.5 2.5 1e-161 538.9 1.7 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFX05607.1 - 1.7e-11 43.3 0.0 1.2e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 EFX05607.1 - 1.1e-05 25.2 2.3 0.038 13.8 0.1 3.3 2 1 0 2 2 2 2 Cell division protein FtsA Ketoacyl-synt_C PF02801.17 EFX05607.1 - 0.0068 16.2 0.0 0.03 14.1 0.0 2.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain RNA_pol_L_2 PF13656.1 EFX05608.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain AAA PF00004.24 EFX05610.1 - 1.8e-09 37.9 0.0 5.2e-09 36.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX05610.1 - 3e-06 27.3 0.0 7.7e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX05610.1 - 2.2e-05 24.0 1.2 0.00016 21.3 0.8 2.5 1 1 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EFX05610.1 - 9.1e-05 21.6 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 EFX05610.1 - 0.00012 21.7 0.0 0.00029 20.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFX05610.1 - 0.00072 19.5 0.7 0.0053 16.7 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EFX05610.1 - 0.00089 20.0 0.0 0.0032 18.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EFX05610.1 - 0.0017 18.2 1.4 0.0079 16.0 0.0 2.7 2 1 1 3 3 3 1 AAA domain Zeta_toxin PF06414.7 EFX05610.1 - 0.0018 17.3 0.1 0.0041 16.2 0.1 1.5 1 0 0 1 1 1 1 Zeta toxin Rad17 PF03215.10 EFX05610.1 - 0.0023 16.7 0.0 0.0035 16.1 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 EFX05610.1 - 0.0034 17.1 0.0 0.0062 16.2 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 EFX05610.1 - 0.0053 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EFX05610.1 - 0.027 14.1 0.1 0.027 14.1 0.1 1.8 2 0 0 2 2 1 0 NTPase IstB_IS21 PF01695.12 EFX05610.1 - 0.047 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF258 PF03193.11 EFX05610.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_18 PF13238.1 EFX05610.1 - 0.088 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Serglycin PF04360.7 EFX05610.1 - 0.11 12.2 7.0 1.1 8.9 1.9 4.1 4 1 0 4 4 4 0 Serglycin PhoH PF02562.11 EFX05610.1 - 0.13 11.4 0.0 0.4 9.8 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.1 EFX05610.1 - 0.67 9.8 0.0 0.67 9.8 0.0 3.2 4 0 0 4 4 4 0 AAA domain MscL PF01741.13 EFX05611.1 - 1.2e-15 57.8 1.2 4e-15 56.0 0.8 1.7 1 1 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.10 EFX05611.1 - 0.0059 16.3 2.3 0.01 15.5 1.6 1.3 1 0 0 1 1 1 1 BED zinc finger C1_1 PF00130.17 EFX05611.1 - 0.011 15.4 1.1 0.016 14.9 0.8 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Hexokinase_1 PF00349.16 EFX05612.1 - 2.3e-22 79.3 0.0 5.7e-22 78.0 0.0 1.6 1 1 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 EFX05612.1 - 3.3e-15 55.9 0.0 7.7e-15 54.7 0.0 1.6 1 1 0 1 1 1 1 Hexokinase DUF2781 PF10914.3 EFX05613.1 - 0.05 13.3 0.6 10 5.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2781) DUF3349 PF11829.3 EFX05614.1 - 0.036 14.4 0.6 3.2 8.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) Peptidase_M3 PF01432.15 EFX05615.1 - 5.4e-150 500.4 0.0 7.4e-150 499.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.1 EFX05615.1 - 0.037 14.0 0.1 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 Effector protein Glyco_hydro_3 PF00933.16 EFX05617.1 - 1e-74 251.2 0.0 1.5e-74 250.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EFX05617.1 - 2.3e-63 213.7 0.0 1.1e-62 211.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EFX05617.1 - 6e-16 58.1 0.1 1.6e-15 56.7 0.1 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EFX05617.1 - 5.7e-12 45.4 0.0 1.1e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Pkinase PF00069.20 EFX05618.1 - 1.2e-25 90.1 0.0 2.4e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05618.1 - 1.5e-16 60.2 0.0 4.8e-16 58.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase NACHT PF05729.7 EFX05618.1 - 2.3e-07 30.6 0.0 7e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain DcpS_C PF11969.3 EFX05619.1 - 5.8e-29 100.6 0.0 1.3e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 EFX05619.1 - 5.9e-22 78.1 0.0 1.9e-21 76.4 0.0 1.9 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal PHP PF02811.14 EFX05619.1 - 3.5e-13 49.7 0.0 6.8e-13 48.7 0.0 1.6 1 1 0 1 1 1 1 PHP domain NMO PF03060.10 EFX05620.1 - 7.4e-70 235.6 0.1 9.8e-70 235.2 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EFX05620.1 - 1.2e-05 24.4 0.0 0.00048 19.1 0.0 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EFX05620.1 - 8.9e-05 21.4 0.4 0.00013 20.9 0.3 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.9 EFX05620.1 - 0.051 12.5 0.0 0.18 10.7 0.0 1.9 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Vps53_N PF04100.7 EFX05621.1 - 6.4e-97 324.7 0.0 1.5e-96 323.4 0.0 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal Sec6 PF06046.8 EFX05621.1 - 9.9e-08 30.5 0.1 7.6e-05 20.9 0.1 2.3 2 0 0 2 2 2 2 Exocyst complex component Sec6 DUF2450 PF10475.4 EFX05621.1 - 5.8e-06 25.4 0.7 1.1e-05 24.5 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Zw10 PF06248.8 EFX05621.1 - 0.0034 15.5 1.6 0.022 12.9 0.5 2.0 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 COG2 PF06148.6 EFX05621.1 - 3.8 7.3 5.8 4.7 7.0 1.2 3.2 3 2 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DAHP_synth_1 PF00793.15 EFX05622.1 - 1.2e-95 319.2 0.0 1.5e-95 318.9 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family p450 PF00067.17 EFX05623.1 - 2e-34 118.9 0.0 3.2e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Hydantoinase_B PF02538.9 EFX05624.1 - 1.3e-183 611.0 0.0 1.8e-183 610.5 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EFX05624.1 - 3.5e-82 275.7 0.0 6.9e-82 274.8 0.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFX05624.1 - 4.5e-52 176.0 0.0 1.1e-50 171.5 0.0 2.4 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region RabGAP-TBC PF00566.13 EFX05625.1 - 1.1e-18 67.4 0.0 1.5e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rho_GDI PF02115.12 EFX05627.1 - 5.4e-52 176.1 0.0 8.5e-51 172.2 0.0 1.9 2 0 0 2 2 2 2 RHO protein GDP dissociation inhibitor Sterol-sensing PF12349.3 EFX05629.1 - 5.5e-32 110.3 7.3 1.6e-31 108.8 5.0 1.9 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 EFX05629.1 - 1.1e-06 26.9 8.5 1.7e-06 26.2 5.9 1.2 1 0 0 1 1 1 1 Patched family WD40 PF00400.27 EFX05629.1 - 0.23 11.4 3.2 0.46 10.4 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Phage_lysozyme PF00959.14 EFX05630.1 - 0.027 14.7 0.3 4.6 7.5 0.1 2.5 2 0 0 2 2 2 0 Phage lysozyme Ndc80_HEC PF03801.8 EFX05630.1 - 0.032 13.6 0.0 0.084 12.3 0.0 1.6 1 0 0 1 1 1 0 HEC/Ndc80p family PSD3 PF07626.6 EFX05630.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) DUF605 PF04652.11 EFX05630.1 - 0.27 10.5 9.8 0.37 10.1 6.8 1.1 1 0 0 1 1 1 0 Vta1 like PT PF04886.7 EFX05630.1 - 0.74 9.1 8.6 4.5 6.6 3.3 2.3 2 0 0 2 2 2 0 PT repeat DUF2217 PF10265.4 EFX05630.1 - 2.9 6.5 6.6 4.4 5.9 4.5 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Corona_nucleoca PF00937.13 EFX05630.1 - 3.7 6.4 12.3 6.2 5.6 8.5 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein TFIIF_alpha PF05793.7 EFX05630.1 - 6.2 5.0 11.9 8.8 4.5 8.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) OPT PF03169.10 EFX05631.1 - 1.4e-207 690.9 34.0 1.7e-207 690.7 23.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Fungal_trans PF04082.13 EFX05632.1 - 0.0012 17.7 0.1 0.0023 16.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05632.1 - 0.0016 18.2 9.8 0.0035 17.2 6.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AraC_N PF06719.8 EFX05632.1 - 0.0028 16.9 0.7 0.0077 15.5 0.5 1.7 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus DUF4557 PF15101.1 EFX05632.1 - 2.5 7.9 7.9 2.5 7.8 4.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) ADH_N PF08240.7 EFX05633.1 - 2.8e-27 94.6 1.6 6.5e-27 93.4 1.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX05633.1 - 3.6e-17 62.1 0.2 3.6e-12 45.9 0.0 2.5 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Shikimate_DH PF01488.15 EFX05633.1 - 0.0032 17.5 0.0 0.0076 16.3 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.9 EFX05633.1 - 0.017 14.4 0.3 0.037 13.4 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 EFX05633.1 - 0.024 14.3 0.1 0.039 13.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 EFX05633.1 - 0.047 13.5 0.4 0.089 12.6 0.3 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ThiF PF00899.16 EFX05633.1 - 0.099 12.4 0.7 0.2 11.4 0.5 1.4 1 0 0 1 1 1 0 ThiF family 2-Hacid_dh_C PF02826.14 EFX05633.1 - 0.16 11.1 0.1 0.27 10.3 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.22 EFX05633.1 - 0.19 12.1 1.4 0.48 10.8 0.6 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX05633.1 - 0.27 11.3 1.3 0.86 9.6 0.4 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Ifi-6-16 PF06140.8 EFX05635.1 - 0.0014 18.3 26.7 0.002 17.8 18.2 1.5 1 1 0 1 1 1 1 Interferon-induced 6-16 family FAM176 PF14851.1 EFX05635.1 - 0.016 14.8 3.1 3.1 7.4 0.9 2.1 2 0 0 2 2 2 0 FAM176 family Nucleoplasmin PF03066.10 EFX05635.1 - 0.15 11.5 3.2 0.19 11.2 2.2 1.1 1 0 0 1 1 1 0 Nucleoplasmin Tom22 PF04281.8 EFX05635.1 - 0.18 11.3 3.6 0.3 10.6 2.5 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Sporozoite_P67 PF05642.6 EFX05635.1 - 0.2 9.4 3.9 0.24 9.1 2.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.1 EFX05635.1 - 1.3 9.4 6.7 1.7 9.0 4.6 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Hydantoinase_B PF02538.9 EFX05636.1 - 4.6e-189 629.0 0.0 6.3e-189 628.5 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EFX05636.1 - 5.2e-91 304.7 0.2 1e-90 303.7 0.0 1.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFX05636.1 - 7.2e-57 191.7 0.7 7.9e-55 185.0 0.0 2.4 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region DNA_binding_1 PF01035.15 EFX05637.1 - 9.7e-24 82.9 0.1 1.2e-22 79.4 0.0 2.2 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain MFS_1 PF07690.11 EFX05638.1 - 7.7e-32 110.3 25.0 9.9e-32 110.0 17.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 EFX05638.1 - 2 8.4 6.4 10 6.2 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1228) T2SE_Nter PF05157.10 EFX05639.1 - 0.038 14.0 0.1 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein E, N-terminal domain SQS_PSY PF00494.14 EFX05640.1 - 0.0066 15.7 0.0 0.0073 15.6 0.0 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF1275 PF06912.6 EFX05641.1 - 3e-39 134.3 17.0 4.7e-39 133.7 11.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Helicase_C PF00271.26 EFX05641.1 - 3.3e-21 74.9 0.0 2.8e-18 65.5 0.0 3.0 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.24 EFX05641.1 - 2.6e-19 69.3 0.0 1e-18 67.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase RQC PF09382.5 EFX05641.1 - 5.3e-10 38.9 0.1 1e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 RQC domain HRDC PF00570.18 EFX05641.1 - 1.3e-05 24.7 0.0 3.3e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 HRDC domain Erp_C PF06780.6 EFX05641.1 - 0.012 15.5 0.1 0.025 14.4 0.1 1.5 1 0 0 1 1 1 0 Erp protein C-terminus ResIII PF04851.10 EFX05641.1 - 0.066 13.0 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFX05641.1 - 0.13 11.0 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF221 PF02714.10 EFX05642.1 - 1.9e-108 362.1 19.2 1.9e-108 362.1 13.3 2.1 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EFX05642.1 - 9e-43 145.5 3.8 9e-43 145.5 2.6 3.6 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EFX05642.1 - 7.5e-29 99.4 0.2 2.4e-28 97.8 0.1 1.9 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 EFX05642.1 - 2e-24 85.8 0.8 3.2e-24 85.2 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) P12 PF12669.2 EFX05643.1 - 0.12 12.5 2.7 0.24 11.6 1.8 1.5 1 0 0 1 1 1 0 Virus attachment protein p12 family DNase_NucA_NucB PF14040.1 EFX05643.1 - 0.39 10.8 3.1 0.49 10.5 2.1 1.3 1 1 0 1 1 1 0 Deoxyribonuclease NucA/NucB Insulin PF00049.13 EFX05643.1 - 1.3 9.8 5.4 4.7 8.0 3.7 1.9 1 1 0 1 1 1 0 Insulin/IGF/Relaxin family NAD_binding_1 PF00175.16 EFX05644.1 - 2.3e-16 60.3 0.0 4e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFX05644.1 - 1.6e-08 34.5 0.0 3.4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EFX05644.1 - 0.0027 17.6 0.0 0.0054 16.6 0.0 1.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain D-aminoacyl_C PF07908.7 EFX05644.1 - 0.066 12.5 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 D-aminoacylase, C-terminal region Aldo_ket_red PF00248.16 EFX05645.1 - 2.5e-34 118.3 0.0 3.2e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family SKG6 PF08693.5 EFX05646.1 - 0.00041 19.5 0.4 0.002 17.4 0.2 2.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rifin_STEVOR PF02009.11 EFX05646.1 - 0.0028 17.3 4.0 0.0042 16.7 1.9 1.9 1 1 0 1 1 1 1 Rifin/stevor family TauD PF02668.11 EFX05647.1 - 4.4e-27 95.3 0.0 4.4e-26 92.1 0.0 1.9 1 1 1 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family O-FucT PF10250.4 EFX05648.1 - 0.0014 17.8 0.0 0.0054 15.8 0.0 1.8 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF4478 PF14793.1 EFX05648.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4478) PTP_N PF12453.3 EFX05648.1 - 0.21 11.2 5.4 4.9 6.8 1.0 2.8 2 0 0 2 2 2 0 Protein tyrosine phosphatase N terminal Cutinase PF01083.17 EFX05649.1 - 3.2e-38 131.2 0.5 3.9e-38 130.9 0.4 1.0 1 0 0 1 1 1 1 Cutinase Abhydrolase_5 PF12695.2 EFX05649.1 - 0.00034 20.3 0.1 0.0004 20.1 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PE-PPE PF08237.6 EFX05649.1 - 0.00083 18.8 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain DUF2974 PF11187.3 EFX05649.1 - 0.008 15.5 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.2 EFX05649.1 - 0.011 15.5 0.1 0.013 15.4 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFX05649.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase ALG3 PF05208.8 EFX05650.1 - 1.1e-141 472.4 9.4 1.3e-141 472.1 6.5 1.0 1 0 0 1 1 1 1 ALG3 protein Fungal_trans PF04082.13 EFX05651.1 - 1.1e-08 34.2 0.1 1.8e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pro_isomerase PF00160.16 EFX05652.1 - 9.1e-48 162.3 0.2 1e-47 162.2 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NAD_binding_6 PF08030.7 EFX05653.1 - 3.2e-20 72.6 0.0 2.2e-17 63.3 0.0 2.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EFX05653.1 - 6.9e-19 68.1 5.8 6.9e-19 68.1 4.0 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EFX05653.1 - 1.9e-16 59.8 0.0 9.7e-16 57.5 0.0 2.1 1 1 0 1 1 1 1 FAD-binding domain DUF3481 PF11980.3 EFX05653.1 - 0.23 11.3 3.3 0.21 11.4 0.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3481) CPSF73-100_C PF11718.3 EFX05655.1 - 6.3e-71 238.1 0.1 6.4e-70 234.8 0.1 2.1 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 EFX05655.1 - 1e-31 109.4 0.0 5.7e-31 107.0 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 EFX05655.1 - 6.5e-14 52.0 0.9 1.4e-13 50.9 0.6 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EFX05655.1 - 7.7e-12 45.1 0.5 1.6e-11 44.1 0.3 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 EFX05655.1 - 1.5e-08 34.2 0.1 3e-08 33.3 0.1 1.5 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 EFX05655.1 - 1.1e-06 28.4 0.2 2.9e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain tRNA-synt_1d PF00750.14 EFX05657.1 - 3.8e-21 75.3 0.3 6e-21 74.6 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 EFX05657.1 - 1.2e-14 54.3 0.1 2.2e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain N-SET PF11764.3 EFX05658.1 - 3.7e-37 127.7 0.2 3.7e-37 127.7 0.2 2.9 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.23 EFX05658.1 - 6.2e-23 81.8 0.0 6.2e-23 81.8 0.0 3.8 3 2 0 3 3 3 1 SET domain SET_assoc PF11767.3 EFX05658.1 - 1.3e-20 72.4 0.4 2.9e-20 71.3 0.3 1.7 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated RRM_5 PF13893.1 EFX05658.1 - 0.012 15.4 0.0 0.049 13.4 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CorA PF01544.13 EFX05660.1 - 1.5e-09 37.2 0.1 2.3e-09 36.7 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PH_6 PF15406.1 EFX05661.1 - 6.3e-46 155.0 3.6 6.3e-46 155.0 2.5 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 EFX05661.1 - 9.5e-05 22.5 0.4 0.00021 21.4 0.0 1.9 2 0 0 2 2 2 1 PH domain PH_4 PF15404.1 EFX05661.1 - 0.0016 17.9 0.0 0.0016 17.9 0.0 2.7 3 0 0 3 3 3 1 Pleckstrin homology domain Peptidase_M20 PF01546.23 EFX05662.1 - 1.2e-26 93.3 0.0 1.9e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX05662.1 - 2.4e-12 46.5 0.0 8.1e-12 44.8 0.0 1.9 2 1 0 2 2 2 1 Peptidase dimerisation domain 5-FTHF_cyc-lig PF01812.15 EFX05663.1 - 4.5e-31 108.0 0.0 5.6e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family OPT PF03169.10 EFX05664.1 - 3.2e-143 478.4 48.7 3.7e-143 478.2 33.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein HET PF06985.6 EFX05665.1 - 2.8e-16 59.9 0.0 7.6e-16 58.5 0.0 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) IBR PF01485.16 EFX05666.1 - 1.2e-12 47.5 3.6 1.2e-12 47.5 2.5 4.3 3 1 0 3 3 3 2 IBR domain zf-C3HC4_3 PF13920.1 EFX05666.1 - 0.0046 16.5 5.2 0.0046 16.5 3.6 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_2 PF13240.1 EFX05666.1 - 0.061 12.8 0.5 0.061 12.8 0.3 3.8 5 0 0 5 5 5 0 zinc-ribbon domain Sgf11 PF08209.6 EFX05666.1 - 0.19 11.0 0.3 0.19 11.0 0.2 4.7 5 0 0 5 5 5 0 Sgf11 (transcriptional regulation protein) DZR PF12773.2 EFX05666.1 - 2.3 8.1 23.7 0.76 9.6 4.0 3.4 2 1 0 2 2 2 0 Double zinc ribbon DNA_ligase_ZBD PF03119.11 EFX05666.1 - 3 7.6 9.1 0.54 10.0 0.1 3.1 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-ribbon_3 PF13248.1 EFX05666.1 - 5.4 6.3 17.7 0.42 9.8 0.3 3.9 4 0 0 4 4 4 0 zinc-ribbon domain Sugar_tr PF00083.19 EFX05667.1 - 4.4e-70 236.4 27.2 5.1e-70 236.2 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05667.1 - 5.2e-14 51.7 31.5 9e-13 47.6 18.4 2.9 1 1 3 4 4 4 4 Major Facilitator Superfamily 4HBT PF03061.17 EFX05669.1 - 1.8e-09 37.6 0.1 1.3e-08 34.8 0.0 2.2 2 0 0 2 2 2 1 Thioesterase superfamily Mito_fiss_reg PF05308.6 EFX05669.1 - 0.026 13.9 3.0 0.049 12.9 2.1 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Pex14_N PF04695.8 EFX05669.1 - 0.099 12.6 0.3 0.15 12.0 0.2 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAD_binding_3 PF01494.14 EFX05670.1 - 1e-65 222.1 0.0 1.4e-65 221.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EFX05670.1 - 0.0011 17.9 0.0 0.47 9.3 0.0 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFX05670.1 - 0.0064 16.8 0.0 0.43 11.0 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX05670.1 - 0.012 15.6 0.0 0.11 12.5 0.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX05670.1 - 0.051 12.0 0.1 1.3 7.3 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.2 EFX05670.1 - 0.083 11.9 0.2 0.18 10.8 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase RPAP2_Rtr1 PF04181.8 EFX05673.1 - 2.9e-16 59.2 0.0 5.7e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF3129 PF11327.3 EFX05675.1 - 2.6e-14 53.4 6.6 2.6e-14 53.4 4.6 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF3129) Kelch_4 PF13418.1 EFX05676.1 - 2e-42 142.7 21.1 5.8e-12 45.1 0.3 6.9 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.1 EFX05676.1 - 1.4e-41 139.8 7.3 1.5e-07 31.1 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 EFX05676.1 - 2.4e-40 135.8 9.3 7.5e-09 35.0 0.4 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 EFX05676.1 - 8.2e-40 134.1 29.6 8.3e-10 38.5 0.1 8.3 9 0 0 9 9 9 6 Galactose oxidase, central domain Kelch_6 PF13964.1 EFX05676.1 - 2.8e-36 122.1 11.3 1.3e-08 34.6 0.1 6.6 4 2 2 6 6 6 6 Kelch motif Kelch_2 PF07646.10 EFX05676.1 - 4.1e-30 102.3 8.0 2.4e-06 27.0 0.2 6.6 6 0 0 6 6 6 6 Kelch motif DUF1777 PF08648.7 EFX05676.1 - 0.0051 16.5 1.9 0.0051 16.5 1.3 3.6 3 1 0 3 3 3 1 Protein of unknown function (DUF1777) Prefoldin_2 PF01920.15 EFX05677.1 - 5.6e-19 67.8 0.8 6.9e-19 67.5 0.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF2205 PF10224.4 EFX05677.1 - 0.013 15.0 0.4 0.018 14.5 0.3 1.2 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) IncA PF04156.9 EFX05677.1 - 0.02 14.4 0.6 0.02 14.4 0.4 1.1 1 0 0 1 1 1 0 IncA protein DASH_Dad3 PF08656.5 EFX05677.1 - 0.046 13.4 0.6 0.063 12.9 0.4 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad3 UBN2 PF14223.1 EFX05677.1 - 0.059 13.1 0.1 0.14 11.9 0.1 1.8 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type p25-alpha PF05517.7 EFX05677.1 - 0.081 13.1 0.1 0.1 12.8 0.1 1.1 1 0 0 1 1 1 0 p25-alpha FliE PF02049.13 EFX05677.1 - 0.31 11.0 2.5 0.4 10.7 1.7 1.1 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE Filament PF00038.16 EFX05678.1 - 0.072 12.5 1.0 0.13 11.6 0.7 1.4 1 0 0 1 1 1 0 Intermediate filament protein KTI12 PF08433.5 EFX05679.1 - 4.2e-62 209.7 0.0 7.5e-62 208.9 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 EFX05679.1 - 3.9e-06 26.8 0.0 6.6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX05679.1 - 0.038 14.8 0.0 0.075 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain Cpn60_TCP1 PF00118.19 EFX05680.1 - 8.2e-142 473.2 9.5 9.4e-142 473.0 6.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Amidohydro_4 PF13147.1 EFX05681.1 - 9.5e-17 61.9 15.5 7.8e-14 52.3 7.6 2.8 2 1 0 3 3 3 2 Amidohydrolase Amidohydro_1 PF01979.15 EFX05681.1 - 3.7e-16 59.7 3.9 2e-10 40.8 0.6 3.0 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_5 PF13594.1 EFX05681.1 - 1.3e-11 44.1 0.0 3.3e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EFX05681.1 - 3.7e-08 33.0 6.8 0.00086 18.6 0.0 3.9 3 1 1 4 4 4 2 Amidohydrolase family Myb_DNA-bind_6 PF13921.1 EFX05682.1 - 4.3e-11 42.7 8.8 5.3e-08 32.8 0.7 3.3 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EFX05682.1 - 1.1e-10 41.3 9.1 1.2e-06 28.5 1.8 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 EFX05682.1 - 4.3e-05 23.5 4.3 0.00087 19.3 0.2 3.1 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Pkinase PF00069.20 EFX05683.1 - 5e-64 215.9 0.0 9.5e-64 215.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05683.1 - 4.7e-36 124.1 0.0 8.1e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 EFX05683.1 - 2.7e-26 91.1 18.7 1.5e-16 59.8 4.0 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.17 EFX05683.1 - 9.4e-21 73.3 27.4 2.1e-12 46.5 5.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 EFX05683.1 - 3.3e-14 53.1 3.1 3.3e-14 53.1 2.1 2.7 3 0 0 3 3 3 1 Protein kinase C terminal domain Kinase-like PF14531.1 EFX05683.1 - 0.023 13.6 0.0 0.036 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like NUDIX PF00293.23 EFX05685.1 - 2.7e-14 52.9 0.1 1.1e-13 50.9 0.0 2.0 2 0 0 2 2 2 1 NUDIX domain F-box-like PF12937.2 EFX05685.1 - 1.5e-05 24.6 0.0 2.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 F-box-like Ribosomal_L6 PF00347.18 EFX05686.1 - 8.3e-23 80.6 0.0 2e-11 44.1 0.0 3.0 3 1 0 3 3 3 2 Ribosomal protein L6 AAA_10 PF12846.2 EFX05687.1 - 5e-09 36.0 0.0 2.1e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain DUF87 PF01935.12 EFX05687.1 - 6.5e-05 22.8 0.1 0.0013 18.5 0.1 2.2 1 1 0 1 1 1 1 Domain of unknown function DUF87 Zot PF05707.7 EFX05687.1 - 0.0011 18.4 0.1 0.007 15.8 0.0 2.1 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) FtsK_SpoIIIE PF01580.13 EFX05687.1 - 0.011 15.1 0.3 0.033 13.6 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF853 PF05872.7 EFX05687.1 - 0.049 11.9 0.0 0.22 9.8 0.0 2.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) AAA_21 PF13304.1 EFX05687.1 - 0.12 12.2 0.2 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.4 EFX05687.1 - 0.13 10.8 0.0 0.32 9.5 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.7 EFX05687.1 - 0.15 11.1 0.0 0.35 9.9 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin Fungal_trans PF04082.13 EFX05688.1 - 7.9e-26 90.4 0.0 5.9e-25 87.6 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05688.1 - 1.8e-09 37.3 11.6 3.2e-09 36.5 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2132 PF09905.4 EFX05688.1 - 0.21 11.5 0.0 0.6 10.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2132) Sad1_UNC PF07738.8 EFX05689.1 - 3.5e-09 36.5 0.0 1.8e-07 31.0 0.0 2.4 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF3475 PF11961.3 EFX05689.1 - 1.1 9.1 3.2 6.4 6.6 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) Trypan_PARP PF05887.6 EFX05689.1 - 2.9 7.6 29.6 0.13 12.0 11.6 2.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF2217 PF10265.4 EFX05691.1 - 1.6 7.3 8.3 2.1 7.0 5.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 EFX05691.1 - 4 5.5 17.5 5.1 5.2 12.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Peptidase_S64 PF08192.6 EFX05691.1 - 8.9 4.5 13.7 12 4.0 9.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Pet127 PF08634.5 EFX05692.1 - 6.4e-118 392.8 3.4 6.4e-118 392.8 2.4 1.7 2 0 0 2 2 2 1 Mitochondrial protein Pet127 DUF4448 PF14610.1 EFX05693.1 - 3.1e-38 131.1 0.2 6.2e-38 130.1 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) SKG6 PF08693.5 EFX05693.1 - 0.0056 15.9 1.6 0.0056 15.9 1.1 2.6 3 0 0 3 3 3 1 Transmembrane alpha-helix domain DUF3377 PF11857.3 EFX05693.1 - 0.1 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Rad60-SLD PF11976.3 EFX05694.1 - 3.1e-20 71.6 0.2 3.9e-20 71.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EFX05694.1 - 5.2e-09 35.3 0.1 6.5e-09 35.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family UPF0121 PF03661.8 EFX05695.1 - 3.5e-12 46.0 4.1 4.9e-12 45.5 2.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Abhydrolase_6 PF12697.2 EFX05696.1 - 6.7e-17 62.1 8.5 2e-16 60.5 5.9 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX05696.1 - 1.3e-08 34.7 0.0 3.4e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05696.1 - 8.3e-06 25.5 0.2 4.3e-05 23.1 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 EFX05696.1 - 0.097 12.2 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) Sulfatase PF00884.18 EFX05697.1 - 1.2e-46 159.3 0.2 1.4e-43 149.3 0.0 3.0 2 1 0 2 2 2 1 Sulfatase Phosphodiest PF01663.17 EFX05697.1 - 8.5e-07 28.6 0.2 3.3e-06 26.6 0.2 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.1 EFX05697.1 - 0.00067 19.9 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF1501 PF07394.7 EFX05697.1 - 0.0055 15.5 0.0 0.017 13.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1501) Epimerase PF01370.16 EFX05698.1 - 6.1e-44 150.2 0.0 8.9e-44 149.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 EFX05698.1 - 4e-24 84.3 0.2 7.1e-24 83.5 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 EFX05698.1 - 2.8e-15 55.7 0.0 9.4e-15 54.0 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EFX05698.1 - 2.9e-15 55.9 0.0 4.3e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EFX05698.1 - 1.4e-13 50.4 0.1 9.6e-12 44.3 0.1 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EFX05698.1 - 8.6e-13 48.5 0.1 1.4e-12 47.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 EFX05698.1 - 5.2e-10 38.6 0.0 1.7e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein KR PF08659.5 EFX05698.1 - 6.3e-08 32.4 0.0 1.2e-07 31.5 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EFX05698.1 - 1.7e-07 31.4 0.0 4.9e-07 29.9 0.0 1.8 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 EFX05698.1 - 0.0023 16.9 0.1 0.0034 16.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase UDPG_MGDP_dh_N PF03721.9 EFX05698.1 - 0.021 14.2 0.1 0.036 13.4 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.19 EFX05698.1 - 0.034 13.0 0.4 0.15 10.8 0.1 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thrombin_light PF09396.5 EFX05698.1 - 0.039 13.5 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 Thrombin light chain Semialdhyde_dh PF01118.19 EFX05698.1 - 0.054 13.7 0.0 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.8 EFX05698.1 - 0.096 11.9 0.0 0.22 10.7 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family Fungal_trans_2 PF11951.3 EFX05699.1 - 1.1e-30 106.4 0.2 3.1e-11 42.5 0.1 3.1 2 1 1 3 3 3 3 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05699.1 - 4.4e-09 36.1 11.6 7.2e-09 35.4 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Orthopox_A49R PF06489.6 EFX05699.1 - 0.015 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Orthopoxvirus A49R protein AT_hook PF02178.14 EFX05699.1 - 0.74 9.6 6.4 2.2 8.2 4.5 1.8 1 0 0 1 1 1 0 AT hook motif Tim17 PF02466.14 EFX05700.1 - 4e-34 117.4 6.6 5.1e-34 117.0 4.6 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family IBN_N PF03810.14 EFX05701.1 - 4.1e-08 33.0 0.0 1.3e-06 28.2 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EFX05701.1 - 0.0048 16.8 0.1 1.1 9.1 0.0 4.3 5 1 0 5 5 5 1 Exportin 1-like protein OapA PF04225.7 EFX05703.1 - 0.063 13.1 0.1 0.46 10.4 0.1 2.2 1 1 1 2 2 2 0 Opacity-associated protein A LysM-like domain WD40 PF00400.27 EFX05704.1 - 7e-24 82.7 8.8 2e-09 36.9 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat SLAC1 PF03595.12 EFX05705.1 - 3.9e-74 249.2 50.1 4.5e-74 249.0 34.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Cu_amine_oxid PF01179.15 EFX05707.1 - 7.6e-114 380.6 3.6 9.2e-114 380.3 2.5 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.5 EFX05707.1 - 1.7e-37 127.1 0.2 4.8e-37 125.6 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.11 EFX05707.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain CENP-M PF11111.3 EFX05707.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Centromere protein M (CENP-M) OmpH PF03938.9 EFX05708.1 - 2.7e-05 24.1 1.4 3.7e-05 23.6 0.9 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) NifU_N PF01592.11 EFX05709.1 - 1.4e-50 170.4 0.0 1.4e-50 170.4 0.0 1.4 2 0 0 2 2 2 1 NifU-like N terminal domain Methyltransf_15 PF09445.5 EFX05711.1 - 9.1e-40 135.8 0.0 1.3e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.2 EFX05711.1 - 5.3e-08 33.4 0.0 8.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05711.1 - 2.2e-06 27.6 0.3 3.4e-06 27.0 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 EFX05711.1 - 1.5e-05 24.6 0.0 2.2e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein DDHD PF02862.12 EFX05711.1 - 0.0034 17.2 1.7 0.0042 16.9 1.2 1.2 1 0 0 1 1 1 1 DDHD domain Cons_hypoth95 PF03602.10 EFX05711.1 - 0.021 14.1 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_5 PF01795.14 EFX05711.1 - 0.039 13.2 0.0 0.052 12.8 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family Sec62 PF03839.11 EFX05711.1 - 3.2 7.0 4.9 5 6.4 3.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Spore_coat_CotO PF14153.1 EFX05711.1 - 3.9 6.8 10.9 5.5 6.3 7.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO FYDLN_acid PF09538.5 EFX05711.1 - 4.9 7.7 32.0 9 6.9 22.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Aminotran_1_2 PF00155.16 EFX05713.1 - 1.1e-35 123.3 0.0 1.3e-35 123.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EFX05713.1 - 1.6e-06 27.4 0.0 2.6e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EFX05713.1 - 4.5e-05 21.9 0.0 7.3e-05 21.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EFX05713.1 - 0.00012 20.9 0.0 0.00019 20.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EFX05713.1 - 0.0036 16.4 0.0 0.0058 15.7 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family EMP70 PF02990.11 EFX05714.1 - 1.7e-196 653.7 4.7 2.1e-196 653.4 3.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 PIRT PF15099.1 EFX05714.1 - 1.9 7.7 5.2 0.51 9.5 1.3 1.8 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family DUF1282 PF06930.7 EFX05715.1 - 0.004 16.8 0.1 0.0054 16.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) Pex14_N PF04695.8 EFX05716.1 - 3.4 7.7 9.6 1.1 9.3 2.7 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ras PF00071.17 EFX05718.1 - 7.8e-57 191.1 0.1 1.2e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX05718.1 - 9.2e-17 61.6 0.0 1.9e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX05718.1 - 2.2e-12 46.5 0.0 3.2e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family EamA PF00892.15 EFX05718.1 - 3.6e-10 39.9 29.7 3.1e-07 30.4 3.0 3.1 3 0 0 3 3 3 2 EamA-like transporter family MMR_HSR1 PF01926.18 EFX05718.1 - 4.6e-07 29.8 0.0 8.9e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 EFX05718.1 - 2e-06 27.1 0.0 5.1e-06 25.7 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EFX05718.1 - 2.7e-05 23.7 0.0 0.00024 20.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF914 PF06027.7 EFX05718.1 - 3.9e-05 22.6 6.2 3.9e-05 22.6 4.3 1.6 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) UAA PF08449.6 EFX05718.1 - 4.9e-05 22.4 7.8 4.9e-05 22.4 5.4 1.5 2 0 0 2 2 2 1 UAA transporter family TPT PF03151.11 EFX05718.1 - 5.6e-05 22.8 2.4 5.6e-05 22.8 1.7 2.9 3 0 0 3 3 3 1 Triose-phosphate Transporter family EmrE PF13536.1 EFX05718.1 - 0.0023 18.1 4.9 0.0023 18.1 3.4 2.8 3 0 0 3 3 2 1 Multidrug resistance efflux transporter AAA_22 PF13401.1 EFX05718.1 - 0.0029 17.7 0.0 0.0065 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFX05718.1 - 0.006 15.7 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SRPRB PF09439.5 EFX05718.1 - 0.014 14.6 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Arch_ATPase PF01637.13 EFX05718.1 - 0.023 14.4 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_24 PF13479.1 EFX05718.1 - 0.025 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EFX05718.1 - 0.027 14.4 0.0 0.069 13.1 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain AAA_10 PF12846.2 EFX05718.1 - 0.03 13.7 0.0 0.068 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain Septin PF00735.13 EFX05718.1 - 0.075 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Septin PduV-EutP PF10662.4 EFX05718.1 - 0.098 12.1 0.1 0.43 10.0 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 EFX05718.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.9 EFX05719.1 - 6.1e-134 440.7 0.0 4.7e-22 78.2 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA PF00004.24 EFX05719.1 - 1.8e-29 102.6 0.0 0.00013 22.2 0.0 7.0 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.6 EFX05719.1 - 2.5e-25 88.6 0.1 8.2e-10 38.4 0.0 7.2 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EFX05719.1 - 4.8e-25 88.7 0.0 0.0032 18.2 0.0 7.6 7 0 0 7 7 6 5 AAA domain AAA_16 PF13191.1 EFX05719.1 - 3.5e-24 85.7 43.1 5.3e-07 29.7 0.7 10.2 9 1 0 9 9 8 5 AAA ATPase domain AAA_22 PF13401.1 EFX05719.1 - 2.1e-23 82.8 0.1 0.0023 18.0 0.0 9.1 9 0 0 9 9 8 5 AAA domain AAA_33 PF13671.1 EFX05719.1 - 3e-22 79.0 0.0 0.026 14.3 0.0 8.0 8 1 0 8 8 6 5 AAA domain AAA_14 PF13173.1 EFX05719.1 - 1.4e-17 63.8 0.0 0.0027 17.6 0.0 7.3 7 0 0 7 7 6 2 AAA domain Sigma54_activat PF00158.21 EFX05719.1 - 3.4e-17 62.4 0.0 0.059 12.8 0.0 6.8 7 0 0 7 7 6 4 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EFX05719.1 - 2.5e-16 59.9 2.3 0.00099 19.1 0.0 8.2 8 0 0 8 8 7 2 Sigma-54 interaction domain AAA_18 PF13238.1 EFX05719.1 - 1.2e-15 57.9 0.4 0.01 16.1 0.0 6.9 6 0 0 6 6 6 3 AAA domain NACHT PF05729.7 EFX05719.1 - 1.4e-14 54.0 9.3 0.12 11.9 0.0 7.0 5 1 0 5 5 5 5 NACHT domain AAA_19 PF13245.1 EFX05719.1 - 5.5e-14 51.6 11.4 0.0054 16.4 0.1 7.3 6 0 0 6 6 6 3 Part of AAA domain AAA_28 PF13521.1 EFX05719.1 - 2.1e-13 50.5 0.1 0.62 10.0 0.0 8.1 8 0 0 8 8 7 1 AAA domain ABC_tran PF00005.22 EFX05719.1 - 5.4e-13 49.4 6.9 0.074 13.3 0.0 6.9 7 0 0 7 7 6 3 ABC transporter AAA_25 PF13481.1 EFX05719.1 - 2.5e-12 46.6 3.9 0.095 12.0 0.0 6.4 6 0 0 6 6 5 3 AAA domain DUF258 PF03193.11 EFX05719.1 - 3.3e-12 45.8 0.6 0.093 11.9 0.0 5.9 6 0 0 6 6 6 3 Protein of unknown function, DUF258 T2SE PF00437.15 EFX05719.1 - 5.2e-12 45.2 2.1 0.0091 14.9 0.1 6.1 7 0 0 7 7 6 3 Type II/IV secretion system protein RNA_helicase PF00910.17 EFX05719.1 - 5.4e-12 45.8 0.1 0.92 9.7 0.0 6.2 6 0 0 6 6 6 2 RNA helicase UPF0079 PF02367.12 EFX05719.1 - 7.8e-12 44.9 2.7 0.01 15.4 0.0 5.5 5 0 0 5 5 5 3 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 EFX05719.1 - 2e-11 43.2 0.1 0.38 10.3 0.0 6.6 6 0 0 6 6 6 1 P-loop containing region of AAA domain MobB PF03205.9 EFX05719.1 - 5.2e-10 39.1 0.1 0.4 10.3 0.0 6.5 6 0 0 6 6 6 2 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 EFX05719.1 - 6.4e-10 38.4 4.2 1.8 7.6 0.0 7.2 7 0 0 7 7 7 2 Zeta toxin Mg_chelatase PF01078.16 EFX05719.1 - 7.3e-10 38.3 7.0 1.8 7.6 0.0 9.0 9 1 0 9 9 9 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 EFX05719.1 - 9.3e-10 38.1 0.6 0.3 10.4 0.0 6.2 6 0 0 6 6 6 1 IstB-like ATP binding protein Arch_ATPase PF01637.13 EFX05719.1 - 7.9e-09 35.5 0.0 0.021 14.5 0.0 5.8 6 0 0 6 6 6 1 Archaeal ATPase Miro PF08477.8 EFX05719.1 - 1.3e-08 35.3 0.2 9.9 6.6 0.0 6.7 6 0 0 6 6 6 0 Miro-like protein RuvB_N PF05496.7 EFX05719.1 - 1.7e-08 33.7 3.3 0.35 9.8 0.0 5.8 6 0 0 6 6 6 2 Holliday junction DNA helicase ruvB N-terminus PduV-EutP PF10662.4 EFX05719.1 - 1.9e-08 33.9 1.0 0.073 12.5 0.0 5.6 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 EFX05719.1 - 1.6e-06 27.9 2.5 1.1 8.9 0.0 5.6 5 0 0 5 5 5 2 NTPase ResIII PF04851.10 EFX05719.1 - 4.3e-06 26.6 4.9 0.074 12.8 0.0 5.7 7 0 0 7 7 4 1 Type III restriction enzyme, res subunit SRP54 PF00448.17 EFX05719.1 - 4.7e-06 26.1 2.9 0.41 10.0 0.0 4.9 6 0 0 6 6 4 1 SRP54-type protein, GTPase domain Rad17 PF03215.10 EFX05719.1 - 3.3e-05 22.7 3.2 2 6.9 0.0 5.0 6 0 0 6 6 6 1 Rad17 cell cycle checkpoint protein TIP49 PF06068.8 EFX05719.1 - 0.00014 20.7 1.4 0.14 10.8 0.0 4.6 5 0 0 5 5 5 1 TIP49 C-terminus MMR_HSR1 PF01926.18 EFX05719.1 - 0.00021 21.2 0.2 28 4.7 0.0 5.7 6 0 0 6 6 5 0 50S ribosome-binding GTPase Dynein_heavy PF03028.10 EFX05719.1 - 0.00031 18.9 0.0 1.2 7.0 0.0 4.0 4 0 0 4 4 4 1 Dynein heavy chain and region D6 of dynein motor DAP3 PF10236.4 EFX05719.1 - 0.00067 18.6 3.1 1.9 7.3 0.0 4.9 5 0 0 5 5 5 1 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.17 EFX05719.1 - 0.0012 17.7 0.1 27 3.5 0.0 4.9 5 0 0 5 5 5 0 NB-ARC domain AAA_7 PF12775.2 EFX05719.1 - 0.0073 15.4 1.9 4.1 6.3 0.0 4.5 5 0 0 5 5 5 0 P-loop containing dynein motor region D3 ATP_bind_1 PF03029.12 EFX05719.1 - 0.0082 15.7 6.1 14 5.1 0.0 5.0 6 0 0 6 6 5 0 Conserved hypothetical ATP binding protein AAA_6 PF12774.2 EFX05719.1 - 0.012 15.2 0.0 4.3 6.8 0.0 4.1 4 0 0 4 4 4 0 Hydrolytic ATP binding site of dynein motor region D1 Bac_DnaA PF00308.13 EFX05719.1 - 0.013 15.2 0.3 51 3.4 0.0 4.8 5 0 0 5 5 5 0 Bacterial dnaA protein KaiC PF06745.8 EFX05719.1 - 0.11 11.5 0.1 32 3.5 0.0 3.9 4 0 0 4 4 4 0 KaiC Septin PF00735.13 EFX05719.1 - 0.22 10.5 0.2 12 4.8 0.0 3.5 4 0 0 4 4 4 0 Septin AAA_21 PF13304.1 EFX05719.1 - 0.31 10.9 0.0 41 4.0 0.0 3.6 5 0 0 5 5 3 0 AAA domain FeoB_N PF02421.13 EFX05719.1 - 0.86 8.8 1.4 19 4.5 0.0 3.4 4 0 0 4 4 4 0 Ferrous iron transport protein B Ras PF00071.17 EFX05719.1 - 3.8 6.8 2.8 1.2e+02 2.0 0.0 3.7 4 0 0 4 4 4 0 Ras family AAA_15 PF13175.1 EFX05719.1 - 5.9 5.8 0.0 41 3.0 0.0 2.3 3 0 0 3 3 2 0 AAA ATPase domain Mito_carr PF00153.22 EFX05720.1 - 3.3e-47 158.1 3.6 2e-19 69.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1857 PF08982.6 EFX05721.1 - 1.5e-31 108.9 0.0 1.7e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) Gar1 PF04410.9 EFX05723.1 - 8.3e-35 119.5 6.4 9.4e-20 70.6 0.0 3.4 3 0 0 3 3 3 2 Gar1/Naf1 RNA binding region SH3_9 PF14604.1 EFX05723.1 - 6.3e-10 38.4 0.0 1.2e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EFX05723.1 - 0.00022 20.6 0.0 0.00045 19.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFX05723.1 - 0.00026 20.3 0.0 0.00047 19.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain IncA PF04156.9 EFX05723.1 - 0.00075 19.1 0.1 0.0019 17.8 0.0 1.6 1 0 0 1 1 1 1 IncA protein Rifin_STEVOR PF02009.11 EFX05723.1 - 0.0018 17.9 3.9 0.0018 17.9 2.7 2.1 2 0 0 2 2 2 1 Rifin/stevor family DUF4293 PF14126.1 EFX05723.1 - 0.059 13.2 0.1 0.059 13.2 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Amnionless PF14828.1 EFX05723.1 - 0.11 10.9 0.0 0.28 9.6 0.0 1.6 1 0 0 1 1 1 0 Amnionless Syndecan PF01034.15 EFX05723.1 - 0.18 11.4 0.0 0.45 10.2 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain SKG6 PF08693.5 EFX05723.1 - 0.18 11.1 1.5 0.63 9.3 1.0 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.10 EFX05723.1 - 0.33 10.5 0.1 0.7 9.4 0.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.1 EFX05723.1 - 0.71 10.3 0.0 0.71 10.3 0.0 2.9 3 0 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain DUF912 PF06024.7 EFX05723.1 - 2.5 8.1 0.0 2.5 8.1 0.0 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Ribosomal_S21 PF01165.15 EFX05724.1 - 8e-14 50.8 3.6 1.4e-13 50.0 2.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 muHD PF10291.4 EFX05725.1 - 2.8e-61 206.9 0.0 4.4e-61 206.3 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.18 EFX05725.1 - 2.8e-08 33.8 0.0 2.8e-08 33.8 0.0 2.2 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain MFS_1 PF07690.11 EFX05726.1 - 6.4e-19 67.8 55.9 5e-17 61.6 36.1 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily IDO PF01231.13 EFX05727.1 - 2.5e-130 434.7 0.0 5.4e-130 433.6 0.0 1.4 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase JAB PF01398.16 EFX05729.1 - 4.1e-08 32.9 0.0 9.7e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Senescence PF06911.7 EFX05730.1 - 1.8e-42 145.0 6.7 3.4e-42 144.1 4.6 1.5 1 0 0 1 1 1 1 Senescence-associated protein She9_MDM33 PF05546.6 EFX05731.1 - 5.8e-74 248.1 3.6 9e-74 247.5 2.5 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family Med8 PF10232.4 EFX05731.1 - 0.033 13.7 0.0 0.033 13.7 0.0 2.2 3 0 0 3 3 3 0 Mediator of RNA polymerase II transcription complex subunit 8 AAA_5 PF07728.9 EFX05731.1 - 0.057 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ADIP PF11559.3 EFX05731.1 - 0.11 12.4 1.9 9 6.1 0.7 3.0 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding BCAS2 PF05700.6 EFX05731.1 - 0.37 10.2 4.2 0.075 12.4 0.2 1.7 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Sfi1 PF08457.5 EFX05732.1 - 1e-51 176.0 76.7 1.9e-49 168.5 52.4 2.1 2 0 0 2 2 2 2 Sfi1 spindle body protein CENP-B_dimeris PF09026.5 EFX05732.1 - 0.0026 17.9 4.1 0.0026 17.9 2.8 4.7 4 0 0 4 4 4 2 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 EFX05732.1 - 0.73 9.4 38.4 0.037 13.6 2.2 4.5 4 0 0 4 4 4 0 Sigma-70, non-essential region DUF2457 PF10446.4 EFX05732.1 - 4.4 5.9 58.0 0.035 12.8 2.2 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2457) Nop14 PF04147.7 EFX05732.1 - 8.3 4.1 34.1 0.89 7.3 4.9 3.9 4 0 0 4 4 4 0 Nop14-like family adh_short PF00106.20 EFX05733.1 - 2.8e-21 76.1 3.8 3.7e-21 75.7 2.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX05733.1 - 4.5e-10 39.6 0.0 6.3e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX05733.1 - 0.00014 21.5 2.6 0.00024 20.8 1.8 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX05733.1 - 0.0019 17.6 0.1 0.0033 16.8 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 EFX05733.1 - 0.002 17.8 1.0 0.0029 17.2 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 EFX05733.1 - 0.023 13.8 0.1 0.04 13.0 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 EFX05733.1 - 0.1 11.4 2.3 1.2 7.9 0.2 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein 4HBT PF03061.17 EFX05734.1 - 0.0026 17.8 0.7 0.022 14.8 0.1 2.5 3 0 0 3 3 3 1 Thioesterase superfamily p450 PF00067.17 EFX05735.1 - 0.00011 20.8 0.0 0.00012 20.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_1 PF00175.16 EFX05736.1 - 1.3e-29 102.8 0.0 2.3e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EFX05736.1 - 1.3e-26 92.6 0.0 2.4e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 EFX05736.1 - 4.8e-21 74.3 0.1 8.9e-21 73.4 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.7 EFX05736.1 - 0.00039 20.3 0.0 0.0042 17.0 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 EFX05736.1 - 0.0037 17.1 0.0 0.0087 16.0 0.0 1.6 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain CusF_Ec PF11604.3 EFX05736.1 - 0.12 12.2 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 Copper binding periplasmic protein CusF ATP-synt_S1 PF05827.7 EFX05738.1 - 6e-30 104.5 0.1 3.5e-29 102.0 0.1 2.1 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) GRAM PF02893.15 EFX05740.1 - 4.7e-16 58.0 0.0 9.7e-16 57.0 0.0 1.6 1 0 0 1 1 1 1 GRAM domain NOA36 PF06524.7 EFX05740.1 - 0.22 10.7 0.1 0.62 9.2 0.1 1.7 1 0 0 1 1 1 0 NOA36 protein 4F5 PF04419.9 EFX05741.1 - 2.2e-06 28.3 9.7 2.2e-06 28.3 6.7 1.6 1 1 1 2 2 2 1 4F5 protein family zf-met2 PF12907.2 EFX05741.1 - 6.3e-05 22.8 0.5 0.00011 22.1 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding HypA PF01155.14 EFX05741.1 - 0.047 13.3 0.2 0.047 13.3 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DUF1682 PF07946.9 EFX05741.1 - 1.5 7.6 5.3 1.8 7.3 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) NAD_binding_2 PF03446.10 EFX05742.1 - 1.7e-27 96.2 0.4 2.8e-27 95.5 0.3 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFX05742.1 - 6.1e-10 39.2 0.0 1.2e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 EFX05742.1 - 0.0039 17.5 0.0 0.0094 16.3 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 EFX05742.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Zn_clus PF00172.13 EFX05743.1 - 9.2e-09 35.0 7.8 9.2e-09 35.0 5.4 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EFX05743.1 - 3.3e-06 26.1 0.0 5.5e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sas10_Utp3 PF04000.10 EFX05744.1 - 2.1e-13 50.2 2.9 3.9e-13 49.4 2.0 1.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF3987 PF13148.1 EFX05744.1 - 3.8 5.9 10.3 0.16 10.4 3.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) TIM21 PF08294.6 EFX05745.1 - 8.1e-44 148.7 0.2 1e-43 148.4 0.1 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.5 EFX05745.1 - 2.3e-06 27.1 0.0 6.4e-06 25.6 0.0 1.8 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Per1 PF04080.8 EFX05746.1 - 9.4e-96 320.3 7.3 1.2e-94 316.6 5.1 2.0 1 1 0 1 1 1 1 Per1-like CCD PF07860.6 EFX05746.1 - 0.035 13.5 0.8 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 WisP family C-Terminal Region CTD PF12815.2 EFX05747.1 - 5.8e-27 94.5 61.4 3.2e-16 59.8 9.6 4.7 1 1 3 4 4 4 3 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5-NGN PF03439.8 EFX05747.1 - 1.4e-24 85.6 0.0 2.3e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 EFX05747.1 - 7.3e-18 64.9 12.1 7.3e-18 64.9 8.4 4.0 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 EFX05747.1 - 4.3e-10 38.8 19.3 1.5e-07 30.8 0.4 5.0 6 0 0 6 6 6 2 KOW motif Thioredoxin PF00085.15 EFX05748.1 - 5.2e-26 90.3 0.0 6.7e-26 90.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.1 EFX05748.1 - 6.1e-05 22.5 0.0 7.5e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFX05748.1 - 0.00071 19.7 0.0 0.014 15.5 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX05748.1 - 0.013 15.5 0.0 0.16 12.0 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like XPC-binding PF09280.6 EFX05748.1 - 0.026 14.0 0.0 0.072 12.5 0.0 1.8 2 0 0 2 2 2 0 XPC-binding domain Thioredoxin_7 PF13899.1 EFX05748.1 - 0.043 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.5 EFX05748.1 - 0.047 13.2 0.0 0.52 9.8 0.0 2.0 1 1 1 2 2 2 0 Redoxin RRM_1 PF00076.17 EFX05749.1 - 1.4e-69 229.6 0.0 2.4e-17 62.2 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX05749.1 - 3.5e-59 196.6 0.1 1.4e-12 47.4 0.0 5.7 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX05749.1 - 3.1e-33 113.4 0.0 6.1e-09 35.6 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4140 PF13600.1 EFX05749.1 - 0.00017 21.9 8.1 0.0052 17.2 0.0 4.5 3 0 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) Nup35_RRM_2 PF14605.1 EFX05749.1 - 0.074 12.8 0.0 32 4.3 0.0 3.5 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Prp19 PF08606.6 EFX05750.1 - 4.2e-30 103.2 2.3 9e-30 102.2 1.6 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.27 EFX05750.1 - 1.3e-16 59.7 1.3 7.3e-05 22.4 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat zf-RING_5 PF14634.1 EFX05750.1 - 0.00011 21.7 1.2 0.00023 20.8 0.8 1.5 1 1 0 1 1 1 1 zinc-RING finger domain PQQ_2 PF13360.1 EFX05750.1 - 0.00074 19.0 3.4 0.00074 19.0 2.3 2.4 2 1 1 3 3 3 1 PQQ-like domain zf-Nse PF11789.3 EFX05750.1 - 0.0012 18.3 0.7 0.0081 15.6 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.1 EFX05750.1 - 0.0024 17.8 0.7 0.0024 17.8 0.5 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) VID27 PF08553.5 EFX05750.1 - 0.013 13.8 0.0 0.024 12.8 0.0 1.3 1 0 0 1 1 1 0 VID27 cytoplasmic protein Cytochrom_D1 PF02239.11 EFX05750.1 - 0.029 12.6 0.4 2.4 6.3 0.0 2.4 1 1 1 2 2 2 0 Cytochrome D1 heme domain Rtf2 PF04641.7 EFX05750.1 - 0.034 13.3 0.2 0.54 9.4 0.0 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger zf-C3HC4 PF00097.20 EFX05750.1 - 0.04 13.5 0.6 0.076 12.6 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 EFX05750.1 - 0.063 12.8 1.0 0.26 10.8 0.6 2.1 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.1 EFX05750.1 - 0.084 12.5 1.8 0.66 9.6 0.6 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EFX05750.1 - 0.1 12.5 0.2 0.35 10.7 0.1 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING MMS1_N PF10433.4 EFX05750.1 - 0.13 10.4 0.1 7 4.6 0.0 2.8 2 1 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term zf-RING_UBOX PF13445.1 EFX05750.1 - 0.13 12.0 0.4 0.37 10.5 0.2 1.7 1 0 0 1 1 1 0 RING-type zinc-finger IceA2 PF05862.6 EFX05750.1 - 0.41 10.3 1.7 3.1 7.5 0.0 3.2 3 0 0 3 3 3 0 Helicobacter pylori IceA2 protein zf-RING_2 PF13639.1 EFX05750.1 - 0.56 10.0 2.7 0.41 10.5 0.4 1.7 2 0 0 2 2 2 0 Ring finger domain SR-25 PF10500.4 EFX05751.1 - 0.065 12.6 13.7 0.55 9.6 6.9 2.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Response_reg PF00072.19 EFX05752.1 - 3.2e-17 62.5 0.7 1.7e-12 47.3 0.1 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.21 EFX05752.1 - 7.4e-14 51.4 0.0 1.4e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EFX05752.1 - 3.6e-08 33.2 0.2 3.6e-08 33.2 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.1 EFX05752.1 - 9.2e-08 32.4 0.1 8.7e-05 22.8 0.0 3.7 3 1 0 3 3 3 1 PAS domain PAS_4 PF08448.5 EFX05752.1 - 0.00026 20.9 1.6 0.16 12.0 0.0 4.2 4 1 0 4 4 4 1 PAS fold GAF_2 PF13185.1 EFX05752.1 - 0.00038 20.9 0.0 0.014 15.9 0.0 2.9 2 0 0 2 2 2 1 GAF domain PAS PF00989.19 EFX05752.1 - 0.0022 17.7 1.7 0.0048 16.6 0.0 2.5 2 2 1 3 3 3 1 PAS fold DUF4141 PF13605.1 EFX05752.1 - 0.0036 16.4 0.1 0.011 14.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4141) PAS_8 PF13188.1 EFX05752.1 - 0.0048 16.7 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.6 EFX05752.1 - 0.13 12.3 1.2 0.24 11.5 0.1 2.0 2 0 0 2 2 2 0 PAS fold Iron_traffic PF04362.9 EFX05753.1 - 0.08 12.3 0.4 1.1 8.7 0.1 2.3 2 0 0 2 2 2 0 Bacterial Fe(2+) trafficking Ribosomal_L1 PF00687.16 EFX05755.1 - 5.7e-51 172.9 0.3 6.8e-51 172.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family M20_dimer PF07687.9 EFX05757.1 - 1.6e-06 27.8 0.1 3.3e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 EFX05757.1 - 2.6e-06 27.0 0.2 3.9e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 zf-C2H2_4 PF13894.1 EFX05758.1 - 0.00013 22.0 13.7 0.52 10.7 0.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger DUF1677 PF07911.8 EFX05758.1 - 0.016 15.3 0.0 0.039 14.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1677) zf-C2H2 PF00096.21 EFX05758.1 - 0.13 12.6 15.9 0.92 9.9 0.4 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type NifZ PF04319.8 EFX05758.1 - 0.13 11.6 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 NifZ domain DUF4222 PF13973.1 EFX05758.1 - 3.2 7.2 7.1 7.2 6.0 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4222) Acetyltransf_7 PF13508.1 EFX05759.1 - 3.6e-05 23.8 0.0 7.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX05759.1 - 0.0091 15.8 0.0 0.026 14.3 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX05759.1 - 0.058 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family NACHT PF05729.7 EFX05760.1 - 5.5e-10 39.1 0.1 1.6e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 EFX05760.1 - 1e-05 24.5 0.4 9.7e-05 21.3 0.0 2.5 2 1 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.1 EFX05760.1 - 2.1e-05 24.6 0.0 2.1e-05 24.6 0.0 3.3 2 2 1 3 3 3 1 AAA ATPase domain KAP_NTPase PF07693.9 EFX05760.1 - 0.00028 19.9 0.0 0.71 8.7 0.0 2.5 1 1 1 2 2 2 2 KAP family P-loop domain AAA_22 PF13401.1 EFX05760.1 - 0.0011 19.0 0.5 0.011 15.8 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 EFX05760.1 - 0.002 17.8 0.2 0.068 12.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 EFX05760.1 - 0.002 17.1 0.3 0.0074 15.3 0.0 2.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.17 EFX05760.1 - 0.0078 16.3 0.0 0.25 11.5 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_17 PF13207.1 EFX05760.1 - 0.014 16.1 0.1 0.15 12.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 EFX05760.1 - 0.027 14.2 0.0 0.073 12.8 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 EFX05760.1 - 0.12 12.6 0.0 0.54 10.4 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EFX05760.1 - 0.19 11.1 1.7 0.7 9.2 0.1 2.6 2 1 1 3 3 3 0 AAA domain Rhodanese PF00581.15 EFX05761.1 - 9e-16 58.2 0.0 1.3e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain His_Phos_2 PF00328.17 EFX05762.1 - 2.7e-127 424.8 0.0 4.2e-127 424.2 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 EFX05762.1 - 3.8e-08 33.0 0.1 7.4e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain MetJ PF01340.15 EFX05762.1 - 0.083 12.6 0.1 0.74 9.6 0.0 2.5 2 1 1 3 3 3 0 Met Apo-repressor, MetJ Fungal_trans PF04082.13 EFX05764.1 - 6.3e-17 61.2 0.9 1.2e-16 60.3 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05764.1 - 1.1e-07 31.6 7.7 3.2e-07 30.1 5.4 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1194 PF06707.6 EFX05765.1 - 0.11 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) DASH_Ask1 PF08655.5 EFX05766.1 - 1.1e-17 63.5 0.0 2.2e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 YqfQ PF14181.1 EFX05766.1 - 0.011 15.7 3.7 0.035 14.1 0.0 2.6 2 0 0 2 2 2 0 YqfQ-like protein FimP PF09766.4 EFX05766.1 - 1.3 8.0 7.4 0.49 9.3 1.0 2.3 2 0 0 2 2 2 0 Fms-interacting protein CHCH PF06747.8 EFX05767.1 - 0.012 15.5 1.6 0.022 14.6 1.1 1.5 1 0 0 1 1 1 0 CHCH domain Pet191_N PF10203.4 EFX05767.1 - 0.042 13.8 2.9 0.14 12.2 2.0 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Nop PF01798.13 EFX05769.1 - 3.9e-50 169.0 3.2 6.9e-50 168.2 2.2 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EFX05769.1 - 1.6e-26 91.8 0.1 3e-26 90.9 0.1 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EFX05769.1 - 2.9e-17 62.5 0.7 1.7e-16 60.1 0.1 2.7 2 0 0 2 2 2 1 NOP5NT (NUC127) domain HIG_1_N PF04588.8 EFX05771.1 - 4.3e-24 84.0 1.3 7.6e-24 83.2 0.9 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region zf-AN1 PF01428.11 EFX05772.1 - 5.1e-24 83.8 20.4 6.7e-12 45.0 5.5 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.16 EFX05772.1 - 0.014 15.2 1.6 0.014 15.2 1.1 2.7 2 1 0 2 2 2 0 IBR domain Transp_Tc5_C PF04236.10 EFX05772.1 - 0.046 13.9 13.4 0.47 10.7 3.1 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain HypA PF01155.14 EFX05772.1 - 5.8 6.6 7.5 0.51 10.0 0.2 2.2 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Amidase PF01425.16 EFX05773.1 - 3.2e-78 263.5 0.0 4.5e-55 187.2 0.1 2.0 1 1 1 2 2 2 2 Amidase MFS_1 PF07690.11 EFX05775.1 - 7.3e-32 110.4 23.0 9.5e-32 110.0 15.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05775.1 - 1e-12 47.4 15.2 1e-12 47.4 10.5 1.7 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.8 EFX05775.1 - 3.2e-06 25.5 1.6 4.7e-06 25.0 1.1 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector PUCC PF03209.10 EFX05775.1 - 8.6e-05 21.4 5.6 8.6e-05 21.4 3.9 2.0 2 0 0 2 2 2 1 PUCC protein OATP PF03137.15 EFX05775.1 - 0.033 12.2 5.3 0.16 10.0 0.3 2.6 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF697 PF05128.7 EFX05775.1 - 0.05 13.1 0.1 0.092 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF697) V_ATPase_I PF01496.14 EFX05775.1 - 0.15 9.9 0.1 0.22 9.3 0.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3353 PF11833.3 EFX05775.1 - 7 6.0 6.7 10 5.5 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3353) Homoserine_dh PF00742.14 EFX05776.1 - 6.8e-50 169.2 0.0 9.3e-50 168.7 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 EFX05776.1 - 6.1e-18 65.3 0.0 1e-17 64.6 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ApbA PF02558.11 EFX05776.1 - 0.12 11.8 0.3 0.26 10.7 0.2 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2OG-FeII_Oxy_3 PF13640.1 EFX05777.1 - 6.7e-05 23.3 0.1 0.00012 22.5 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-Fe_Oxy_2 PF10014.4 EFX05777.1 - 0.032 13.6 0.2 0.056 12.8 0.1 1.3 1 0 0 1 1 1 0 2OG-Fe dioxygenase Cyt-b5 PF00173.23 EFX05778.1 - 5.3e-19 67.7 0.5 1.8e-18 66.1 0.1 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 EFX05778.1 - 1.6e-08 34.9 22.5 3.1e-08 34.0 14.1 2.1 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily Per1 PF04080.8 EFX05778.1 - 0.023 14.1 1.6 0.032 13.6 1.1 1.2 1 0 0 1 1 1 0 Per1-like Anth_synt_I_N PF04715.8 EFX05778.1 - 0.041 13.8 0.1 0.082 12.9 0.1 1.4 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region LrgB PF04172.11 EFX05778.1 - 0.095 11.8 0.3 0.45 9.6 0.0 2.0 2 0 0 2 2 2 0 LrgB-like family ATP_synt_I PF03899.10 EFX05778.1 - 4.3 7.5 6.2 2.8 8.1 0.2 2.2 2 0 0 2 2 2 0 ATP synthase I chain 2OG-FeII_Oxy_2 PF13532.1 EFX05779.1 - 1.6e-27 96.6 0.0 1.4e-26 93.5 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 EFX05779.1 - 0.014 15.6 0.0 0.41 10.9 0.0 2.3 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 EFX05779.1 - 0.037 14.5 0.0 0.12 12.8 0.0 1.9 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF2781 PF10914.3 EFX05780.1 - 2.9e-30 105.0 6.8 3.5e-30 104.7 4.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Vps5 PF09325.5 EFX05781.1 - 1.8e-12 47.0 1.3 2.8e-12 46.4 0.9 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 EFX05781.1 - 4.6e-07 29.6 0.0 8.4e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 PX domain TPR_17 PF13431.1 EFX05781.1 - 0.011 15.8 0.1 0.036 14.2 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Seryl_tRNA_N PF02403.17 EFX05781.1 - 0.019 14.9 2.4 0.054 13.5 1.7 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MarB PF13999.1 EFX05781.1 - 0.027 14.0 0.1 0.073 12.6 0.1 1.7 1 0 0 1 1 1 0 MarB protein TPR_12 PF13424.1 EFX05781.1 - 0.047 13.6 2.2 0.06 13.2 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1814 PF08843.6 EFX05782.1 - 0.0039 17.0 0.0 0.0071 16.1 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) AIM24 PF01987.12 EFX05784.1 - 4.4e-37 127.6 0.0 1.1e-36 126.3 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF4402 PF14352.1 EFX05784.1 - 1.9 8.9 6.8 0.49 10.8 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4402) Furin-like PF00757.15 EFX05785.1 - 0.077 12.6 9.2 0.13 11.9 6.3 1.3 1 1 0 1 1 1 0 Furin-like cysteine rich region TIL PF01826.12 EFX05785.1 - 6 7.0 10.5 18 5.5 1.2 2.4 1 1 1 2 2 2 0 Trypsin Inhibitor like cysteine rich domain ABC_tran PF00005.22 EFX05787.1 - 6.6e-48 162.4 0.6 1.3e-27 96.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 EFX05787.1 - 2.5e-25 89.2 50.9 8.5e-21 74.3 16.2 2.8 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.1 EFX05787.1 - 5.5e-22 79.0 0.0 2.7e-05 24.2 0.0 4.3 3 1 0 4 4 4 4 AAA domain AAA_29 PF13555.1 EFX05787.1 - 2.1e-10 39.9 5.2 0.00014 21.3 0.2 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EFX05787.1 - 1.7e-07 31.7 2.7 0.011 16.0 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX05787.1 - 2.3e-07 31.0 3.1 0.002 18.1 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 EFX05787.1 - 2.4e-07 30.2 5.6 0.11 11.6 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EFX05787.1 - 2.5e-06 26.7 2.0 0.029 13.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_30 PF13604.1 EFX05787.1 - 0.00015 21.3 2.4 1.8 8.1 0.1 3.7 3 0 0 3 3 3 2 AAA domain ArgK PF03308.11 EFX05787.1 - 0.00064 18.5 0.4 0.16 10.7 0.1 2.5 2 0 0 2 2 2 1 ArgK protein Zeta_toxin PF06414.7 EFX05787.1 - 0.0023 17.0 0.8 1.5 7.8 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_15 PF13175.1 EFX05787.1 - 0.003 16.6 0.0 1.8 7.5 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain SRP54 PF00448.17 EFX05787.1 - 0.011 15.1 0.3 5.8 6.3 0.2 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain DUF3989 PF13150.1 EFX05787.1 - 0.012 15.0 0.6 5.3 6.5 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) AAA_25 PF13481.1 EFX05787.1 - 0.014 14.8 0.6 1.7 7.9 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.1 EFX05787.1 - 0.016 15.1 0.0 7 6.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 EFX05787.1 - 0.018 15.1 0.9 4 7.5 0.2 3.1 2 1 0 2 2 2 0 AAA domain MutS_V PF00488.16 EFX05787.1 - 0.04 13.3 0.3 9.1 5.6 0.0 2.6 3 0 0 3 3 2 0 MutS domain V AAA_19 PF13245.1 EFX05787.1 - 0.055 13.2 5.6 3.5 7.4 0.2 4.1 3 0 0 3 3 3 0 Part of AAA domain Miro PF08477.8 EFX05787.1 - 0.1 13.1 0.2 5 7.6 0.0 2.8 2 0 0 2 2 2 0 Miro-like protein AAA_13 PF13166.1 EFX05787.1 - 0.11 10.9 0.0 1.4 7.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EFX05787.1 - 0.13 11.6 1.4 12 5.1 0.5 2.4 2 0 0 2 2 2 0 AAA-like domain G-alpha PF00503.15 EFX05787.1 - 0.2 10.2 0.2 2.8 6.5 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit AIG1 PF04548.11 EFX05787.1 - 0.78 8.8 2.6 2 7.4 0.4 2.3 2 0 0 2 2 2 0 AIG1 family AAA PF00004.24 EFX05787.1 - 1.7 8.8 4.0 18 5.4 0.2 3.3 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Mak10 PF04112.8 EFX05788.1 - 1.9e-16 59.7 0.0 3.3e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase CTK3 PF12243.3 EFX05789.1 - 9.3e-56 187.3 0.1 1.2e-55 186.9 0.1 1.1 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.3 EFX05789.1 - 1.4e-18 66.7 9.3 2.8e-18 65.6 6.4 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus MAM33 PF02330.11 EFX05789.1 - 0.0084 15.8 0.1 0.014 15.1 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein CD99L2 PF12301.3 EFX05789.1 - 1.2 8.7 4.7 2.1 8.0 3.3 1.3 1 0 0 1 1 1 0 CD99 antigen like protein 2 adh_short PF00106.20 EFX05790.1 - 1.8e-24 86.5 3.8 7.2e-24 84.5 2.6 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX05790.1 - 5.1e-12 45.8 0.9 6.5e-12 45.4 0.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EFX05790.1 - 5.9e-09 35.6 0.1 7.3e-09 35.3 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX05790.1 - 3.1e-05 24.0 2.0 6.8e-05 22.9 1.4 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EFX05790.1 - 4.5e-05 22.4 0.6 0.00013 21.0 0.4 1.6 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 EFX05790.1 - 0.0015 17.2 0.1 0.0019 16.9 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EFX05790.1 - 0.012 14.5 0.2 0.018 13.9 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF3842 PF12953.2 EFX05790.1 - 0.047 13.8 0.4 0.09 12.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) RmlD_sub_bind PF04321.12 EFX05790.1 - 0.069 12.0 0.2 0.1 11.4 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Saccharop_dh PF03435.13 EFX05790.1 - 0.11 11.4 0.3 0.13 11.2 0.2 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase DUF3402 PF11882.3 EFX05791.1 - 7e-154 512.7 0.0 1.1e-153 512.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.8 EFX05791.1 - 3.1e-70 236.3 0.0 5e-70 235.6 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein Nop14 PF04147.7 EFX05791.1 - 0.42 8.4 5.1 0.69 7.7 3.5 1.2 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 EFX05791.1 - 6 6.3 8.2 13 5.3 5.7 1.5 1 0 0 1 1 1 0 Nucleoplasmin GMC_oxred_N PF00732.14 EFX05792.1 - 1.7e-09 37.2 0.0 6.9e-09 35.2 0.0 1.9 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX05792.1 - 3.8e-08 33.7 2.6 1.6e-07 31.7 0.2 2.9 3 0 0 3 3 3 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EFX05792.1 - 0.00043 19.2 0.4 0.00082 18.3 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 EFX05792.1 - 0.0047 15.8 0.0 0.0082 15.0 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX05792.1 - 0.0066 15.5 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX05792.1 - 0.034 14.0 0.2 0.081 12.7 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX05792.1 - 0.061 13.3 2.3 0.073 13.1 0.4 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Tyrosinase PF00264.15 EFX05793.1 - 5.4e-53 180.4 3.6 5.4e-53 180.4 2.5 1.9 2 0 0 2 2 2 1 Common central domain of tyrosinase Yippee-Mis18 PF03226.9 EFX05794.1 - 1.3e-22 79.5 0.3 1.5e-22 79.4 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly NUDIX PF00293.23 EFX05795.1 - 4.2e-17 62.0 0.1 7.5e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.6 EFX05795.1 - 3.5e-14 52.9 0.4 1.3e-12 47.8 0.1 2.8 2 1 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.6 EFX05795.1 - 4.3e-09 35.7 0.4 7.8e-09 34.8 0.3 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain ATP-synt_G PF04718.10 EFX05796.1 - 1.6e-26 92.9 0.2 2.8e-26 92.1 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Pap_E4 PF02711.9 EFX05796.1 - 0.061 14.1 2.1 0.098 13.4 1.5 1.3 1 0 0 1 1 1 0 E4 protein SR-25 PF10500.4 EFX05796.1 - 0.47 9.8 11.6 0.71 9.3 8.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sporozoite_P67 PF05642.6 EFX05796.1 - 1.1 7.0 4.8 1.4 6.7 3.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen E2R135 PF11570.3 EFX05798.1 - 0.062 13.3 1.6 1.1 9.2 0.0 3.0 2 1 1 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 Baculo_PEP_C PF04513.7 EFX05798.1 - 0.19 11.5 4.9 4.8 7.0 0.1 3.5 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Peptidase_S8 PF00082.17 EFX05799.1 - 7.1e-45 153.3 8.8 7.1e-45 153.3 6.1 1.9 2 0 0 2 2 2 1 Subtilase family DUF1034 PF06280.7 EFX05799.1 - 1.2e-11 45.0 1.7 2.1e-10 40.9 0.2 3.1 3 0 0 3 3 3 1 Fn3-like domain (DUF1034) PA PF02225.17 EFX05799.1 - 1.6e-09 37.3 0.1 5.1e-09 35.7 0.0 1.9 1 0 0 1 1 1 1 PA domain Sugar_tr PF00083.19 EFX05800.1 - 1.3e-88 297.5 25.7 1.5e-88 297.3 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05800.1 - 8.4e-32 110.2 50.8 7.2e-24 84.1 18.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 EFX05800.1 - 0.0027 15.8 8.4 0.017 13.1 2.4 2.9 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Mem_trans PF03547.13 EFX05800.1 - 0.015 13.6 8.6 0.048 11.9 0.5 2.5 1 1 1 2 2 2 0 Membrane transport protein 5_3_exonuc PF01367.15 EFX05800.1 - 0.13 12.4 0.1 0.36 11.0 0.0 1.7 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold tRNA-synt_1b PF00579.20 EFX05801.1 - 2.7e-24 85.8 0.0 4e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) SET PF00856.23 EFX05802.1 - 1.1e-12 48.6 0.0 1.2e-11 45.2 0.0 2.3 1 1 0 1 1 1 1 SET domain SAF PF08666.7 EFX05802.1 - 0.039 14.3 0.0 15 6.0 0.0 2.6 2 0 0 2 2 2 0 SAF domain TPR_14 PF13428.1 EFX05802.1 - 0.11 13.2 1.9 0.34 11.6 0.2 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 EFX05802.1 - 0.25 11.2 1.4 1.2 9.0 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat CBFD_NFYB_HMF PF00808.18 EFX05803.1 - 4.9e-26 90.5 1.3 8.7e-26 89.7 0.9 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EFX05803.1 - 3.9e-07 30.0 0.1 6.4e-07 29.3 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 EFX05803.1 - 0.0018 18.0 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.8 EFX05803.1 - 0.0029 17.3 0.0 0.0047 16.6 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.8 EFX05803.1 - 0.085 13.1 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A RNA_pol PF00940.14 EFX05804.1 - 5.2e-160 532.3 0.0 7.7e-160 531.8 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 EFX05804.1 - 1.6e-80 270.7 11.6 2.2e-80 270.2 3.4 2.3 2 0 0 2 2 2 2 DNA-directed RNA polymerase N-terminal PK PF00224.16 EFX05805.1 - 2.5e-168 559.1 4.1 3e-168 558.8 2.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 EFX05805.1 - 2.4e-29 101.2 0.0 6.6e-29 99.8 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 EFX05805.1 - 0.00012 21.0 0.6 0.00066 18.6 0.2 2.1 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DJ-1_PfpI_N PF13587.1 EFX05806.1 - 3.8e-21 74.3 0.2 7.6e-21 73.3 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family DJ-1_PfpI PF01965.19 EFX05806.1 - 1.5e-16 60.1 0.6 3.1e-16 59.1 0.4 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.9 EFX05806.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain CN_hydrolase PF00795.17 EFX05807.1 - 6.9e-28 97.2 0.1 1.1e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans PF04082.13 EFX05807.1 - 0.018 13.9 0.0 0.035 12.9 0.0 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain RXT2_N PF08595.6 EFX05807.1 - 0.2 11.4 0.3 0.4 10.4 0.2 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Sulphotransf PF09037.5 EFX05808.1 - 0.059 12.8 0.4 0.092 12.2 0.3 1.2 1 0 0 1 1 1 0 Stf0 sulphotransferase DUF996 PF06195.8 EFX05808.1 - 5 7.1 11.5 0.79 9.7 1.1 3.1 2 1 1 4 4 4 0 Protein of unknown function (DUF996) K_oxygenase PF13434.1 EFX05810.1 - 1.1e-104 350.0 0.0 3e-102 342.0 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 EFX05810.1 - 9.8e-11 42.0 0.0 2.1e-10 41.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EFX05810.1 - 1.1e-08 35.0 0.0 8e-08 32.2 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EFX05810.1 - 9.3e-05 22.3 0.0 0.0012 18.8 0.0 2.4 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF4147 PF13660.1 EFX05810.1 - 0.067 12.2 0.0 8.3 5.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) Copper-fist PF00649.13 EFX05811.1 - 1.2e-21 75.5 1.4 1.2e-21 75.5 1.0 4.0 1 1 3 4 4 4 1 Copper fist DNA binding domain Fungal_trans PF04082.13 EFX05814.1 - 3.5e-05 22.7 0.0 6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ras PF00071.17 EFX05815.1 - 1.3e-57 193.6 0.0 1.5e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX05815.1 - 3.7e-20 72.6 0.0 5.5e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX05815.1 - 1.1e-13 50.8 0.0 2.2e-13 49.7 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EFX05815.1 - 2.6e-06 26.9 0.0 6.3e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFX05815.1 - 6.4e-06 25.4 0.0 8.1e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFX05815.1 - 4.5e-05 23.3 0.0 0.00014 21.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 EFX05815.1 - 0.0068 16.4 0.0 0.0089 16.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX05815.1 - 0.072 13.2 0.0 0.24 11.5 0.0 1.8 2 1 0 2 2 2 0 AAA domain Ferrochelatase PF00762.14 EFX05816.1 - 2e-91 306.3 0.0 2.3e-91 306.0 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase eRF1_1 PF03463.10 EFX05818.1 - 3.1e-29 101.2 0.1 6e-29 100.2 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.10 EFX05818.1 - 2.8e-18 66.5 0.0 4.5e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EFX05818.1 - 7.6e-16 58.3 0.0 1.8e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 Guanylate_cyc_2 PF09778.4 EFX05818.1 - 0.024 13.8 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 Guanylylate cyclase DUF3494 PF11999.3 EFX05820.1 - 2.2e-50 171.1 18.0 3e-50 170.7 12.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3494) HhH-GPD PF00730.20 EFX05821.1 - 0.00034 20.8 0.0 0.00076 19.7 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein TT_ORF2 PF02957.10 EFX05821.1 - 0.084 13.5 0.4 5.6 7.6 0.0 2.6 2 0 0 2 2 2 0 TT viral ORF2 Methyltransf_11 PF08241.7 EFX05823.1 - 5.3e-18 65.2 0.0 1.4e-17 63.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05823.1 - 1.2e-11 44.8 0.0 1.8e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05823.1 - 2.7e-10 40.0 0.0 3.7e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05823.1 - 5.9e-10 39.7 0.0 1e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05823.1 - 2.9e-08 34.1 0.0 4.4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX05823.1 - 3.6e-07 29.5 0.0 5.6e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFX05823.1 - 2e-06 27.8 0.8 5.5e-06 26.4 0.6 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX05823.1 - 6.1e-05 22.7 0.0 8.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX05823.1 - 0.053 12.9 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DREV PF05219.7 EFX05823.1 - 0.079 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase ECH PF00378.15 EFX05824.1 - 1.2e-47 162.0 1.4 7.1e-47 159.5 1.0 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 EFX05824.1 - 0.0068 16.2 0.1 0.012 15.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase family S49 MFS_1 PF07690.11 EFX05825.1 - 1.4e-13 50.3 20.1 1.9e-13 49.8 13.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4500 PF14937.1 EFX05825.1 - 0.031 14.0 0.1 0.069 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) zf-DHHC PF01529.15 EFX05826.1 - 6.4e-30 103.8 0.7 9.8e-30 103.2 0.0 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase MARVEL PF01284.18 EFX05828.1 - 1.2 9.0 13.2 1.6 8.5 8.5 1.7 1 1 1 2 2 2 0 Membrane-associating domain DUF1777 PF08648.7 EFX05829.1 - 7.6e-07 29.0 10.5 1.9e-06 27.7 4.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) zf-C2H2_jaz PF12171.3 EFX05829.1 - 0.00056 19.9 0.2 0.00097 19.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX05829.1 - 0.034 14.3 0.3 0.052 13.7 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type AKAP95 PF04988.7 EFX05829.1 - 0.14 11.8 0.2 0.34 10.6 0.0 1.7 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Atg14 PF10186.4 EFX05829.1 - 0.47 9.3 6.3 0.043 12.7 1.1 1.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3340 PF11818.3 EFX05829.1 - 0.96 9.3 13.2 0.39 10.6 3.3 2.1 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) KAR9 PF08580.5 EFX05830.1 - 8.5e-121 404.3 5.1 2.2e-76 257.6 0.0 2.3 2 0 0 2 2 2 2 Yeast cortical protein KAR9 ELYS PF13934.1 EFX05830.1 - 0.026 14.2 0.6 0.047 13.4 0.4 1.3 1 0 0 1 1 1 0 Nuclear pore complex assembly DUF3829 PF12889.2 EFX05830.1 - 2.8 7.0 4.2 6.2 5.9 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3829) Syntaxin-6_N PF09177.6 EFX05830.1 - 3.4 8.1 10.7 0.34 11.3 0.9 3.5 4 0 0 4 4 4 0 Syntaxin 6, N-terminal Fungal_trans PF04082.13 EFX05831.1 - 2.4e-19 69.2 0.0 3.8e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05831.1 - 1.4e-06 28.0 9.3 1.4e-06 28.0 6.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FtsJ PF01728.14 EFX05832.1 - 8.5e-60 201.8 0.0 1.1e-59 201.4 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF2410 PF10307.4 EFX05833.1 - 1.4e-76 256.3 0.0 1.8e-76 255.9 0.0 1.1 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) CDC45 PF02724.9 EFX05833.1 - 0.29 9.1 0.3 0.42 8.5 0.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Arginase PF00491.16 EFX05834.1 - 5e-78 262.1 0.6 1e-76 257.8 0.4 2.0 1 1 0 1 1 1 1 Arginase family Imm21 PF15569.1 EFX05834.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 21 AP_endonuc_2 PF01261.19 EFX05835.1 - 5.9e-35 120.4 2.8 8.2e-35 120.0 2.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel SKG6 PF08693.5 EFX05836.1 - 4.7e-06 25.8 3.7 4.7e-06 25.8 2.6 2.1 2 0 0 2 2 2 1 Transmembrane alpha-helix domain WSC PF01822.14 EFX05836.1 - 5.5e-06 26.2 9.3 1.2e-05 25.0 6.5 1.6 1 0 0 1 1 1 1 WSC domain DUF4448 PF14610.1 EFX05836.1 - 0.00031 20.2 0.2 0.00046 19.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Podoplanin PF05808.6 EFX05836.1 - 0.00033 20.2 2.7 0.0006 19.4 1.9 1.4 1 0 0 1 1 1 1 Podoplanin Rifin_STEVOR PF02009.11 EFX05836.1 - 0.0016 18.1 0.1 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 Rifin/stevor family Rax2 PF12768.2 EFX05836.1 - 0.0032 16.7 0.4 0.0067 15.6 0.3 1.5 1 1 0 1 1 1 1 Cortical protein marker for cell polarity DUF3185 PF11381.3 EFX05836.1 - 0.0097 15.6 5.7 0.65 9.7 4.5 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF3185) DUF1191 PF06697.7 EFX05836.1 - 0.01 14.6 0.6 0.016 14.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) DUF2076 PF09849.4 EFX05836.1 - 0.012 15.6 0.1 0.017 15.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) EphA2_TM PF14575.1 EFX05836.1 - 0.047 14.0 2.1 0.13 12.6 0.0 2.6 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain MtrF PF09472.5 EFX05836.1 - 0.063 12.5 2.8 0.14 11.3 1.9 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Romo1 PF10247.4 EFX05836.1 - 0.069 13.3 0.2 0.47 10.6 0.0 2.2 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 TMEM154 PF15102.1 EFX05836.1 - 0.082 12.6 1.9 0.16 11.6 1.3 1.5 1 0 0 1 1 1 0 TMEM154 protein family Gram_pos_anchor PF00746.16 EFX05836.1 - 0.14 12.0 0.5 0.36 10.6 0.4 1.8 1 0 0 1 1 1 0 Gram positive anchor DUF2500 PF10694.4 EFX05836.1 - 0.47 10.4 0.1 0.47 10.4 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) CAML PF14963.1 EFX05837.1 - 1.1 8.5 6.5 1.3 8.2 2.9 2.2 1 1 1 2 2 2 0 Calcium signal-modulating cyclophilin ligand p450 PF00067.17 EFX05838.1 - 2.8e-73 247.0 0.0 3.8e-73 246.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.15 EFX05838.1 - 1.2e-26 93.5 0.0 6.5e-26 91.1 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EFX05838.1 - 7.6e-26 90.8 0.0 1.7e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EFX05838.1 - 1.7e-12 47.8 0.0 4.2e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_NdrI PF07972.6 EFX05838.1 - 0.00027 20.8 0.0 0.00062 19.6 0.0 1.6 1 0 0 1 1 1 1 NrdI Flavodoxin like Chitin_synth_2 PF03142.10 EFX05839.1 - 9.6e-24 83.6 3.8 2.6e-20 72.3 2.5 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.1 EFX05839.1 - 1.5e-18 67.4 0.1 3.5e-18 66.2 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EFX05839.1 - 2e-17 63.5 10.3 2e-17 63.5 7.1 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 EFX05839.1 - 0.0098 15.5 0.1 3.7 7.2 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 HORMA PF02301.13 EFX05840.1 - 9.5e-19 67.7 0.0 1.1e-13 51.2 0.0 2.1 2 0 0 2 2 2 2 HORMA domain NACHT PF05729.7 EFX05841.1 - 9.3e-05 22.1 0.0 0.0007 19.2 0.0 2.4 3 0 0 3 3 3 1 NACHT domain NB-ARC PF00931.17 EFX05841.1 - 0.00011 21.1 0.0 0.00023 20.0 0.0 1.5 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 EFX05841.1 - 0.00015 21.9 0.0 0.0011 19.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain WD40 PF00400.27 EFX05841.1 - 0.00016 21.4 0.0 0.0013 18.5 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF3639 PF12341.3 EFX05841.1 - 0.00037 20.4 3.0 0.069 13.1 0.0 4.1 4 0 0 4 4 4 1 Protein of unknown function (DUF3639) Torsin PF06309.6 EFX05841.1 - 0.0031 17.3 0.0 0.01 15.6 0.0 1.8 2 0 0 2 2 2 1 Torsin RNA_helicase PF00910.17 EFX05841.1 - 0.014 15.5 0.0 0.035 14.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.1 EFX05841.1 - 0.015 15.3 0.1 0.071 13.0 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain CNF1 PF05785.7 EFX05841.1 - 0.024 13.5 0.0 3.8 6.3 0.0 2.3 2 0 0 2 2 2 0 Rho-activating domain of cytotoxic necrotizing factor Zeta_toxin PF06414.7 EFX05841.1 - 0.043 12.9 0.0 0.36 9.8 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.4 EFX05841.1 - 0.11 11.4 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Acetyltransf_1 PF00583.19 EFX05842.1 - 9.3e-11 41.6 0.2 1.7e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX05842.1 - 5.7e-08 32.8 0.0 8.5e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX05842.1 - 0.0029 17.3 0.7 0.35 10.6 0.0 2.3 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_9 PF13527.1 EFX05842.1 - 0.0032 17.3 0.0 0.011 15.5 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EFX05842.1 - 0.0082 16.1 0.0 0.012 15.5 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFX05842.1 - 0.057 13.5 0.0 0.1 12.7 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EFX05842.1 - 0.077 12.8 0.1 0.11 12.3 0.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.20 EFX05843.1 - 8.3e-71 238.1 0.0 1.8e-70 237.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05843.1 - 1.2e-36 126.0 0.0 2.5e-36 125.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase SWIB PF02201.13 EFX05843.1 - 2.7e-06 26.9 0.0 7.5e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain Med15 PF09606.5 EFX05843.1 - 0.00016 20.0 41.1 0.00016 20.0 28.5 1.8 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Kinase-like PF14531.1 EFX05843.1 - 0.001 18.0 0.1 0.0078 15.2 0.0 2.4 2 1 0 2 2 2 1 Kinase-like TFIIA PF03153.8 EFX05843.1 - 3.2 7.5 41.6 0.23 11.3 20.8 2.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.1 EFX05843.1 - 5.7 5.7 16.3 11 4.9 11.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RTA1 PF04479.8 EFX05844.1 - 1.2e-37 129.5 0.5 1.7e-37 129.1 0.3 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF1748 PF08520.5 EFX05846.1 - 1e-34 117.9 0.1 1.3e-34 117.6 0.1 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) MFS_1 PF07690.11 EFX05847.1 - 7.9e-15 54.4 33.5 7.9e-15 54.4 23.2 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFX05847.1 - 2.8e-06 26.9 10.8 3.9e-06 26.4 4.0 3.3 2 1 2 4 4 4 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.19 EFX05847.1 - 0.00014 20.6 6.9 0.00015 20.4 3.8 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter PUCC PF03209.10 EFX05847.1 - 0.0016 17.2 0.5 0.0016 17.2 0.4 2.0 2 1 0 2 2 2 1 PUCC protein bZIP_1 PF00170.16 EFX05848.1 - 0.00077 19.3 5.5 0.0016 18.3 3.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor p450 PF00067.17 EFX05849.1 - 3.2e-49 167.7 0.0 5.1e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF2014 PF09427.5 EFX05851.1 - 2.9e-77 259.3 2.0 2.9e-75 252.7 1.4 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.21 EFX05851.1 - 6.9e-17 60.9 0.9 1.4e-16 59.8 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain OmpH PF03938.9 EFX05851.1 - 1.2 9.0 24.8 0.053 13.4 6.2 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) LysM PF01476.15 EFX05852.1 - 1.8e-26 91.7 0.3 2.8e-06 27.1 0.0 5.7 6 0 0 6 6 6 5 LysM domain DUF1903 PF08991.5 EFX05852.1 - 1.6 8.9 5.1 73 3.6 0.0 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF1903) p450 PF00067.17 EFX05854.1 - 2.8e-67 227.2 0.0 3.7e-67 226.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AAA PF00004.24 EFX05855.1 - 1.9e-47 160.7 0.0 3.5e-42 143.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EFX05855.1 - 1.8e-06 27.4 0.0 0.00017 21.0 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.9 EFX05855.1 - 1e-05 25.5 0.0 2.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFX05855.1 - 1.5e-05 25.0 1.3 0.00017 21.6 0.1 3.3 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.1 EFX05855.1 - 5.7e-05 23.2 0.1 0.0019 18.3 0.0 2.9 2 1 0 2 2 1 1 AAA domain Bromodomain PF00439.20 EFX05855.1 - 0.00081 19.2 0.0 0.003 17.4 0.0 1.9 1 0 0 1 1 1 1 Bromodomain AAA_5 PF07728.9 EFX05855.1 - 0.0012 18.5 0.0 0.0055 16.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EFX05855.1 - 0.0012 17.9 0.0 0.021 13.8 0.0 2.5 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus Sigma54_activ_2 PF14532.1 EFX05855.1 - 0.0021 18.1 0.0 0.17 11.8 0.0 2.7 3 0 0 3 3 2 1 Sigma-54 interaction domain AAA_19 PF13245.1 EFX05855.1 - 0.0033 17.1 0.2 0.037 13.7 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 EFX05855.1 - 0.0035 18.1 0.1 0.021 15.6 0.0 2.5 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EFX05855.1 - 0.004 17.0 2.4 0.0096 15.7 0.0 2.8 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.8 EFX05855.1 - 0.0075 15.0 0.0 0.012 14.3 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_18 PF13238.1 EFX05855.1 - 0.012 15.9 0.9 0.064 13.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EFX05855.1 - 0.013 15.3 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 EFX05855.1 - 0.017 14.0 0.1 3.1 6.5 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Parvo_NS1 PF01057.12 EFX05855.1 - 0.02 13.7 0.0 0.16 10.8 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.17 EFX05855.1 - 0.025 14.7 0.0 0.07 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 EFX05855.1 - 0.03 14.6 0.0 0.36 11.1 0.0 2.6 2 0 0 2 2 2 0 ABC transporter Mg_chelatase PF01078.16 EFX05855.1 - 0.053 12.6 0.8 0.14 11.2 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EFX05855.1 - 0.077 12.4 0.0 4.7 6.6 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.7 EFX05855.1 - 0.091 12.4 0.4 0.51 9.9 0.1 2.4 2 1 0 2 2 2 0 NACHT domain AAA_3 PF07726.6 EFX05855.1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 EFX05855.1 - 0.16 11.1 0.2 0.89 8.7 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein Torsin PF06309.6 EFX05855.1 - 0.44 10.4 0.0 2.1 8.2 0.0 2.0 2 0 0 2 2 2 0 Torsin LPP PF04728.8 EFX05856.1 - 0.0076 16.0 1.1 0.012 15.3 0.8 1.2 1 0 0 1 1 1 1 Lipoprotein leucine-zipper DUF1689 PF07954.6 EFX05856.1 - 0.039 13.8 0.0 0.045 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) BLOC1_2 PF10046.4 EFX05856.1 - 0.04 14.0 0.1 0.053 13.6 0.1 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ketoacyl-synt PF00109.21 EFX05857.1 - 2e-73 247.0 0.2 8e-73 245.0 0.0 2.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EFX05857.1 - 1.2e-34 118.6 0.4 2.3e-34 117.7 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 EFX05857.1 - 3.5e-07 29.4 0.1 5.8e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 EFX05857.1 - 0.0037 16.9 0.4 0.022 14.4 0.1 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III His_Phos_1 PF00300.17 EFX05860.1 - 4.3e-08 33.4 0.0 2.2e-06 27.8 0.0 2.9 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) Vps8 PF12816.2 EFX05861.1 - 6.8e-70 234.3 0.0 1.5e-69 233.2 0.0 1.6 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.15 EFX05861.1 - 5.7e-05 22.7 0.0 1 8.9 0.0 3.8 3 1 1 4 4 4 2 Region in Clathrin and VPS zf-RING_5 PF14634.1 EFX05861.1 - 0.0043 16.7 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EFX05861.1 - 0.012 15.4 0.2 0.032 14.0 0.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.2 EFX05861.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EFX05861.1 - 0.23 11.5 0.0 0.54 10.3 0.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2158 PF09926.4 EFX05862.1 - 0.066 12.6 0.7 0.14 11.6 0.5 1.6 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2158) Nup84_Nup100 PF04121.8 EFX05864.1 - 1.8e-45 154.8 0.1 1.7e-30 105.3 0.0 4.1 3 1 1 4 4 4 4 Nuclear pore protein 84 / 107 TEX19 PF15553.1 EFX05865.1 - 0.042 13.7 0.0 0.051 13.4 0.0 1.2 1 0 0 1 1 1 0 Testis-expressed protein 19 zf-Di19 PF05605.7 EFX05866.1 - 0.013 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Atg14 PF10186.4 EFX05866.1 - 0.091 11.6 1.6 0.19 10.6 1.1 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 zf-C2HC_2 PF13913.1 EFX05866.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.1 EFX05866.1 - 0.15 11.2 0.2 0.29 10.4 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2 PF00096.21 EFX05866.1 - 0.16 12.3 0.1 0.32 11.4 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type FYDLN_acid PF09538.5 EFX05866.1 - 3.5 8.2 13.6 11 6.7 4.6 3.5 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) CBF PF03914.12 EFX05867.1 - 7.1e-48 162.1 0.1 2.4e-47 160.4 0.1 2.0 1 0 0 1 1 1 1 CBF/Mak21 family Ligase_CoA PF00549.14 EFX05868.1 - 1.1e-33 115.9 0.3 1.5e-15 57.1 0.0 2.5 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.14 EFX05868.1 - 5.2e-14 52.5 0.0 1.7e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.1 EFX05868.1 - 1.2e-10 41.1 0.1 6.3e-07 29.0 0.0 3.3 2 1 1 3 3 3 2 Succinyl-CoA ligase like flavodoxin domain IPK PF03770.11 EFX05869.1 - 5.7e-53 179.4 0.0 1.1e-52 178.5 0.0 1.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase Monellin PF09200.5 EFX05869.1 - 0.038 13.6 0.2 0.083 12.5 0.1 1.6 1 0 0 1 1 1 0 Monellin Dus PF01207.12 EFX05871.1 - 1.6e-35 122.4 0.0 2.8e-24 85.5 0.0 2.8 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 EFX05871.1 - 2.2 8.0 9.7 4.4 7.0 1.2 2.6 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FNIP_N PF14636.1 EFX05872.1 - 1.8e-31 109.3 0.0 1.8e-31 109.3 0.0 3.8 3 1 0 3 3 3 1 Folliculin-interacting protein N-terminus RNA_pol_N PF01194.12 EFX05873.1 - 3.6e-30 103.7 2.0 4.3e-30 103.5 1.4 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Corona_5a PF06336.6 EFX05873.1 - 0.11 12.3 0.3 0.15 11.9 0.2 1.5 1 1 0 1 1 1 0 Coronavirus 5a protein Aminotran_1_2 PF00155.16 EFX05874.1 - 1.9e-62 211.3 0.0 2.3e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DAO PF01266.19 EFX05875.1 - 3.6e-28 98.4 2.9 4.9e-28 98.0 2.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX05875.1 - 0.0007 19.5 0.0 0.0019 18.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFX05875.1 - 0.0044 17.3 0.1 0.0095 16.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX05875.1 - 0.0063 15.4 0.0 0.01 14.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX05875.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX05875.1 - 0.022 13.8 0.1 0.038 13.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.11 EFX05875.1 - 0.071 12.5 0.1 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.17 EFX05875.1 - 0.096 11.5 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.14 EFX05875.1 - 0.12 11.3 0.1 0.22 10.5 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain DUF4174 PF13778.1 EFX05878.1 - 0.015 15.3 0.6 0.036 14.1 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) Methyltransf_3 PF01596.12 EFX05878.1 - 0.41 9.6 2.2 0.77 8.7 0.5 2.0 2 0 0 2 2 2 0 O-methyltransferase TFCD_C PF12612.3 EFX05880.1 - 3.2e-18 65.8 0.0 4.7e-17 62.0 0.0 2.7 2 1 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT PF02985.17 EFX05880.1 - 1.1 9.4 16.6 0.43 10.7 0.0 6.8 7 0 0 7 7 7 0 HEAT repeat AhpC-TSA_2 PF13911.1 EFX05881.1 - 1.1e-11 44.7 0.0 1.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Acid_PPase PF12689.2 EFX05882.1 - 2.9e-53 179.9 0.0 4.4e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 Acid Phosphatase HAD_2 PF13419.1 EFX05882.1 - 0.0012 19.1 0.4 0.095 12.9 0.0 3.0 2 1 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Glyco_trans_4_4 PF13579.1 EFX05882.1 - 0.005 16.9 0.4 0.005 16.9 0.3 2.1 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain MFS_1 PF07690.11 EFX05883.1 - 2.7e-19 69.1 65.3 6.7e-11 41.4 20.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EFX05883.1 - 0.00026 19.5 34.7 0.0039 15.6 9.0 2.3 1 1 1 2 2 2 2 MFS/sugar transport protein DUF4137 PF13593.1 EFX05884.1 - 4.9e-85 285.3 14.6 5.8e-85 285.1 10.1 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.11 EFX05884.1 - 1.7e-09 37.3 6.8 4.1e-09 36.1 4.7 1.7 1 0 0 1 1 1 1 Sodium Bile acid symporter family Serglycin PF04360.7 EFX05885.1 - 0.00014 21.6 4.3 0.00014 21.6 3.0 4.0 4 0 0 4 4 4 1 Serglycin F-box PF00646.28 EFX05886.1 - 0.00058 19.4 0.0 0.00058 19.4 0.0 2.5 2 1 0 2 2 2 1 F-box domain PRANC PF09372.5 EFX05886.1 - 0.0092 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 PRANC domain F-box-like PF12937.2 EFX05886.1 - 0.051 13.3 0.0 0.051 13.3 0.0 3.3 3 1 0 3 3 3 0 F-box-like MFS_1 PF07690.11 EFX05887.1 - 1.2e-16 60.3 44.8 2.4e-08 33.0 18.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX05887.1 - 6.6e-15 54.6 20.7 4.7e-14 51.8 14.0 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter DUF4078 PF13300.1 EFX05888.1 - 2.1e-15 56.6 1.7 2.1e-15 56.6 1.2 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) DUF903 PF06004.7 EFX05888.1 - 0.023 14.2 1.2 0.039 13.4 0.2 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF903) Ion_trans PF00520.26 EFX05889.1 - 1.4e-06 27.7 18.8 2.3e-06 27.0 10.6 2.7 2 1 0 2 2 2 1 Ion transport protein PKD_channel PF08016.7 EFX05889.1 - 1.4e-05 23.7 11.7 0.0021 16.5 0.9 2.2 1 1 1 2 2 2 2 Polycystin cation channel DUF3814 PF12769.2 EFX05889.1 - 0.053 13.6 1.5 0.081 13.0 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3814) Peptidase_M28 PF04389.12 EFX05890.1 - 4.7e-26 91.6 0.1 6.9e-26 91.0 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EFX05890.1 - 5.3e-05 22.8 0.0 9.6e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Mmp37 PF09139.6 EFX05891.1 - 2e-131 437.9 0.0 2.5e-131 437.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 DUF21 PF01595.15 EFX05892.1 - 2e-32 111.9 0.1 3.5e-32 111.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF21 IF-2B PF01008.12 EFX05892.1 - 2.2e-24 85.9 0.0 4.6e-24 84.8 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.23 EFX05892.1 - 1e-08 34.8 0.0 2.3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain CBS PF00571.23 EFX05892.1 - 2.7e-05 23.8 0.1 0.041 13.6 0.0 2.8 2 0 0 2 2 2 2 CBS domain E1_dh PF00676.15 EFX05893.1 - 5.1e-85 284.7 0.0 6e-85 284.5 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 EFX05893.1 - 0.0012 18.4 0.1 0.01 15.4 0.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 EFX05893.1 - 0.061 12.2 0.0 0.33 9.8 0.0 1.9 1 1 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase HEAT PF02985.17 EFX05894.1 - 0.038 14.0 1.3 9.8 6.5 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat Nop25 PF09805.4 EFX05895.1 - 3.9e-33 114.4 15.2 3.9e-33 114.4 10.6 2.6 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) PSK_trans_fac PF07704.6 EFX05895.1 - 4 8.1 7.8 2.6 8.7 3.5 2.1 2 0 0 2 2 2 0 Rv0623-like transcription factor Reticulon PF02453.12 EFX05896.1 - 1.7e-36 125.3 2.9 2.2e-36 124.9 2.0 1.1 1 0 0 1 1 1 1 Reticulon Ctr PF04145.10 EFX05896.1 - 0.11 12.5 0.5 0.48 10.4 0.0 2.0 1 1 1 2 2 2 0 Ctr copper transporter family DD_K PF12121.3 EFX05896.1 - 0.45 10.4 3.3 0.98 9.3 2.3 1.5 1 0 0 1 1 1 0 Dermaseptin Mucin PF01456.12 EFX05896.1 - 1 9.1 5.7 2 8.1 4.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein AAA_3 PF07726.6 EFX05897.1 - 0.053 13.1 0.1 0.095 12.3 0.1 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Myb_Cef PF11831.3 EFX05898.1 - 4.4e-50 170.0 0.4 4.4e-50 170.0 0.3 3.4 3 1 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.26 EFX05898.1 - 2.8e-21 75.3 1.9 6.8e-10 38.8 0.1 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX05898.1 - 1.3e-20 73.2 6.0 2.9e-14 52.9 0.8 2.8 1 1 1 2 2 2 2 Myb-like DNA-binding domain Aminotran_3 PF00202.16 EFX05899.1 - 6.3e-87 291.5 0.1 7.4e-87 291.3 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EFX05899.1 - 3.6e-06 26.1 0.0 1.2e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFX05899.1 - 0.00029 19.6 0.0 0.051 12.3 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V HECT PF00632.20 EFX05900.1 - 2e-78 263.7 0.0 3.3e-78 263.0 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HEAT PF02985.17 EFX05900.1 - 1.3e-06 28.0 1.3 0.0066 16.4 0.1 4.5 3 0 0 3 3 3 1 HEAT repeat Arm PF00514.18 EFX05900.1 - 5.8e-05 22.7 2.0 0.057 13.2 0.1 5.2 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 EFX05900.1 - 0.00033 21.0 0.4 0.02 15.3 0.0 3.9 4 0 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.1 EFX05900.1 - 0.0017 18.6 3.2 0.42 10.9 0.0 3.7 3 1 0 3 3 3 2 HEAT repeats Ribosomal_L1 PF00687.16 EFX05901.1 - 1.2e-52 178.3 0.2 1.2e-52 178.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family Filament PF00038.16 EFX05903.1 - 0.0085 15.5 0.3 0.022 14.2 0.1 1.7 1 1 0 1 1 1 1 Intermediate filament protein Abhydrolase_5 PF12695.2 EFX05904.1 - 4.6e-07 29.6 0.2 2e-06 27.6 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05905.1 - 9.4e-29 100.5 0.0 3.7e-28 98.6 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX05905.1 - 2.4e-12 47.2 2.1 8e-12 45.5 1.5 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX05905.1 - 0.06 13.1 0.4 0.29 10.8 0.3 2.1 2 1 0 2 2 2 0 Alpha/beta hydrolase family Methyltransf_23 PF13489.1 EFX05906.1 - 2.3e-18 66.4 0.0 6.4e-18 64.9 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05906.1 - 3.4e-16 59.4 0.0 2.9e-13 50.1 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05906.1 - 2.1e-10 40.9 0.0 9.3e-08 32.4 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX05906.1 - 3.6e-10 39.6 0.0 0.0024 17.4 0.0 3.0 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05906.1 - 2e-09 38.0 0.0 4.1e-07 30.5 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX05906.1 - 3.3e-07 29.6 0.0 1.7e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX05906.1 - 3.3e-06 27.3 0.0 4.2e-05 23.8 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX05906.1 - 0.00024 20.1 0.0 0.0017 17.4 0.0 2.2 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_26 PF13659.1 EFX05906.1 - 0.0045 17.0 0.0 0.029 14.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX05906.1 - 0.0085 16.0 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 EFX05906.1 - 0.021 14.4 0.0 0.05 13.2 0.0 1.7 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_16 PF10294.4 EFX05906.1 - 0.024 14.0 0.0 0.054 12.9 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.9 EFX05906.1 - 0.028 13.8 0.0 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain HTH_Tnp_Tc5 PF03221.11 EFX05907.1 - 1.1e-17 63.5 3.3 2.9e-17 62.2 0.2 2.6 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain Med15 PF09606.5 EFX05907.1 - 0.0093 14.2 19.1 0.016 13.4 13.3 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4259 PF14078.1 EFX05907.1 - 2.3 8.7 8.2 13 6.2 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) GTP1_OBG PF01018.17 EFX05907.1 - 6 6.5 7.8 0.92 9.1 1.4 2.3 3 0 0 3 3 3 0 GTP1/OBG LysM PF01476.15 EFX05908.1 - 3e-15 55.8 1.6 0.0015 18.3 0.0 4.9 4 0 0 4 4 4 4 LysM domain HTH_Tnp_1 PF01527.15 EFX05908.1 - 5.5e-07 29.4 0.0 0.29 11.1 0.0 3.5 3 0 0 3 3 3 3 Transposase HTH_28 PF13518.1 EFX05908.1 - 0.094 12.7 0.0 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Mad3_BUB1_I PF08311.7 EFX05909.1 - 2.9e-42 143.4 0.7 5.4e-42 142.5 0.1 1.7 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Pkinase PF00069.20 EFX05909.1 - 9e-12 44.6 0.0 1.7e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX05909.1 - 0.01 14.9 0.0 0.062 12.3 0.0 1.9 2 0 0 2 2 2 0 Protein tyrosine kinase PI3K_1B_p101 PF10486.4 EFX05909.1 - 2.5 5.5 4.5 0.85 7.1 0.4 1.8 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ADH_N PF08240.7 EFX05910.1 - 2.5e-24 85.1 2.1 4.3e-24 84.3 1.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX05910.1 - 3.9e-09 36.1 0.4 2.1e-08 33.7 0.3 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX05910.1 - 5.2e-05 24.1 0.0 0.0001 23.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase S1-like PF14444.1 EFX05910.1 - 0.00012 21.7 0.4 0.012 15.3 0.1 2.6 2 0 0 2 2 2 1 S1-like NADH_4Fe-4S PF10589.4 EFX05910.1 - 0.72 9.0 3.4 1.7 7.8 2.3 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Glyco_transf_15 PF01793.11 EFX05911.1 - 1.7e-142 474.3 8.2 2e-142 474.0 5.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Cas_csx3 PF09620.5 EFX05912.1 - 0.08 12.7 0.0 0.34 10.7 0.0 2.0 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_csx3) GST_C PF00043.20 EFX05913.1 - 6.9e-11 41.9 0.0 1.2e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EFX05913.1 - 1.5e-09 37.5 0.4 8.2e-08 32.0 0.1 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EFX05913.1 - 6.4e-09 36.2 0.0 4.3e-08 33.5 0.1 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EFX05913.1 - 4.2e-06 26.8 0.0 8.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EFX05913.1 - 4.5e-06 26.5 0.0 8.3e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EFX05913.1 - 1.3e-05 25.3 0.0 3.9e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain HpcH_HpaI PF03328.9 EFX05914.1 - 2.1e-37 128.1 0.1 2.5e-37 127.8 0.1 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family UQ_con PF00179.21 EFX05915.1 - 1.7e-35 121.4 0.0 1.9e-35 121.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EFX05915.1 - 0.0028 17.4 0.1 0.0052 16.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RNA_pol_Rpb2_6 PF00562.23 EFX05916.1 - 7.5e-118 393.6 0.0 7.5e-118 393.6 0.0 1.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EFX05916.1 - 6.3e-54 181.9 0.1 1.6e-53 180.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 EFX05916.1 - 3.8e-28 97.5 0.2 9.9e-28 96.2 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.9 EFX05916.1 - 2.1e-24 85.9 0.4 5.1e-23 81.4 0.3 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 EFX05916.1 - 2.4e-21 75.2 0.0 4.5e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.8 EFX05916.1 - 4.6e-19 67.9 0.1 1.1e-18 66.8 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.12 EFX05916.1 - 5.1e-11 42.3 1.0 1.2e-10 41.1 0.0 2.2 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 5 DUF202 PF02656.10 EFX05917.1 - 0.0069 16.5 4.5 0.0069 16.5 3.1 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF202) Na_Ca_ex PF01699.19 EFX05918.1 - 4.8e-44 149.3 34.3 2.3e-22 79.0 8.7 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Vps52 PF04129.7 EFX05919.1 - 2.1e-123 412.5 0.0 2.8e-123 412.1 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.4 EFX05919.1 - 0.012 13.8 0.2 0.012 13.8 0.1 1.8 2 0 0 2 2 2 0 Exocyst complex component Sec3 Mer2 PF09074.5 EFX05919.1 - 0.015 15.1 0.3 0.033 14.0 0.2 1.5 1 0 0 1 1 1 0 Mer2 PLU-1 PF08429.6 EFX05919.1 - 0.026 13.4 0.4 0.32 9.8 0.1 2.3 2 0 0 2 2 2 0 PLU-1-like protein DUF1664 PF07889.7 EFX05919.1 - 0.049 13.4 0.4 0.1 12.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 EFX05919.1 - 0.44 10.3 2.7 0.89 9.4 0.2 2.5 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Metallophos PF00149.23 EFX05920.1 - 5.1e-42 143.5 1.2 6.3e-42 143.2 0.8 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GFA PF04828.9 EFX05921.1 - 2.2e-09 37.1 0.0 2.5e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DUF3128 PF11326.3 EFX05922.1 - 1.9e-25 88.7 1.3 3.6e-25 87.8 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Tropomyosin_1 PF12718.2 EFX05923.1 - 8e-48 161.9 30.0 9.3e-48 161.7 20.8 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 EFX05923.1 - 7.8e-08 31.6 29.5 0.00013 21.1 7.0 3.0 1 1 2 3 3 3 3 Tropomyosin CENP-F_leu_zip PF10473.4 EFX05923.1 - 0.00097 19.0 5.2 0.00097 19.0 3.6 2.8 1 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.6 EFX05923.1 - 0.0053 16.6 25.4 0.063 13.0 6.0 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Surfac_D-trimer PF09006.6 EFX05923.1 - 0.0076 15.9 0.0 0.0076 15.9 0.0 2.7 4 0 0 4 4 1 1 Lung surfactant protein D coiled-coil trimerisation DUF4200 PF13863.1 EFX05923.1 - 0.0082 16.0 29.2 0.061 13.2 8.2 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4200) KLRAQ PF10205.4 EFX05923.1 - 0.0088 16.0 5.1 0.0088 16.0 3.5 2.7 1 1 2 3 3 3 1 Predicted coiled-coil domain-containing protein Spc7 PF08317.6 EFX05923.1 - 0.009 14.7 24.5 0.019 13.6 5.1 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein Cortex-I_coil PF09304.5 EFX05923.1 - 0.014 15.3 22.4 0.83 9.7 0.1 3.2 1 1 2 3 3 3 0 Cortexillin I, coiled coil GAS PF13851.1 EFX05923.1 - 0.015 14.5 27.2 0.11 11.6 12.6 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Myosin_tail_1 PF01576.14 EFX05923.1 - 0.018 12.7 28.7 0.023 12.4 19.9 1.1 1 0 0 1 1 1 0 Myosin tail Cast PF10174.4 EFX05923.1 - 0.028 12.5 24.1 0.033 12.2 16.7 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Lebercilin PF15619.1 EFX05923.1 - 0.028 13.8 30.6 0.14 11.5 8.2 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.3 EFX05923.1 - 0.037 13.9 28.2 0.038 13.8 5.7 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.5 EFX05923.1 - 0.039 14.0 14.1 0.64 10.1 1.8 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family U3_assoc_6 PF08640.6 EFX05923.1 - 0.049 13.4 0.3 0.049 13.4 0.2 2.2 1 1 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 DUF3287 PF11690.3 EFX05923.1 - 0.049 13.6 0.9 0.049 13.6 0.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3287) FliD_C PF07195.7 EFX05923.1 - 0.052 12.8 9.1 0.063 12.5 6.3 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus APG6 PF04111.7 EFX05923.1 - 0.062 12.3 30.6 0.49 9.3 10.2 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 PilJ PF13675.1 EFX05923.1 - 0.073 13.3 12.7 0.62 10.4 0.8 3.0 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Herpes_pp85 PF04637.7 EFX05923.1 - 0.086 11.1 1.7 0.14 10.4 1.2 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF3829 PF12889.2 EFX05923.1 - 0.098 11.8 16.5 0.25 10.5 11.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3829) ERM PF00769.14 EFX05923.1 - 0.1 12.0 32.5 0.18 11.3 10.3 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Mod_r PF07200.8 EFX05923.1 - 0.17 11.7 21.5 0.59 10.0 1.8 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein bZIP_1 PF00170.16 EFX05923.1 - 0.18 11.8 30.3 0.68 9.9 1.5 4.4 1 1 3 4 4 4 0 bZIP transcription factor TACC PF05010.9 EFX05923.1 - 0.18 11.5 15.5 0.59 9.8 10.7 1.8 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) DUF3584 PF12128.3 EFX05923.1 - 0.21 8.9 23.9 0.51 7.6 16.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3166 PF11365.3 EFX05923.1 - 0.23 11.9 17.4 0.18 12.2 6.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3166) CCDC155 PF14662.1 EFX05923.1 - 0.37 10.3 29.8 1.1 8.8 7.2 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 TMF_TATA_bd PF12325.3 EFX05923.1 - 0.57 9.9 23.8 4.9 6.9 11.2 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding IFT46_B_C PF12317.3 EFX05923.1 - 0.6 9.4 3.9 0.42 9.9 1.5 1.6 1 1 1 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal TMF_DNA_bd PF12329.3 EFX05923.1 - 0.67 9.7 30.6 2.2 8.1 6.6 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.1 EFX05923.1 - 0.69 8.3 19.2 1.2 7.4 13.3 1.4 1 1 0 1 1 1 0 AAA domain Vps5 PF09325.5 EFX05923.1 - 0.69 9.1 19.3 0.049 12.8 8.0 2.2 1 1 1 2 2 2 0 Vps5 C terminal like Herpes_capsid PF06112.6 EFX05923.1 - 1 9.3 3.9 0.5 10.4 0.2 2.2 2 1 1 3 3 2 0 Gammaherpesvirus capsid protein Taxilin PF09728.4 EFX05923.1 - 1.2 8.1 26.1 1.7e+02 1.1 17.4 2.2 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF4201 PF13870.1 EFX05923.1 - 1.2 8.5 21.5 1.4 8.3 6.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) TMP_2 PF06791.8 EFX05923.1 - 1.5 8.3 6.6 1.2 8.7 1.4 2.0 1 1 1 2 2 2 0 Prophage tail length tape measure protein Seryl_tRNA_N PF02403.17 EFX05923.1 - 1.6 8.7 24.7 0.86 9.6 0.3 3.1 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.6 EFX05923.1 - 1.9 7.9 24.2 7 6.0 5.8 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 CDC37_N PF03234.9 EFX05923.1 - 2 8.7 19.4 10 6.3 13.4 2.0 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding FlaC_arch PF05377.6 EFX05923.1 - 2 8.3 15.0 23 4.9 0.3 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) MAD PF05557.8 EFX05923.1 - 2.3 6.1 25.9 0.51 8.3 7.3 1.8 1 1 0 1 1 1 0 Mitotic checkpoint protein Uso1_p115_C PF04871.8 EFX05923.1 - 2.6 7.9 23.6 3.7 7.4 8.2 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 PF11932.3 EFX05923.1 - 2.9 7.0 20.9 4.1 6.5 5.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CENP-K PF11802.3 EFX05923.1 - 3.1 6.9 13.5 0.027 13.7 0.8 2.2 1 1 1 2 2 2 0 Centromere-associated protein K Laminin_II PF06009.7 EFX05923.1 - 3.2 7.5 13.7 0.85 9.3 2.7 2.7 1 1 1 2 2 2 0 Laminin Domain II rRNA_proc-arch PF13234.1 EFX05923.1 - 3.4 6.7 12.2 0.27 10.3 2.5 2.5 1 1 1 2 2 2 0 rRNA-processing arch domain SDH_alpha PF03313.10 EFX05923.1 - 3.7 6.4 5.0 7.1 5.5 3.5 1.7 1 1 0 1 1 1 0 Serine dehydratase alpha chain IncA PF04156.9 EFX05923.1 - 3.9 7.0 28.2 7e+02 -0.4 19.5 2.2 1 1 0 1 1 1 0 IncA protein FUSC PF04632.7 EFX05923.1 - 4 5.7 5.6 4.4 5.6 3.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.4 EFX05923.1 - 4 6.2 22.4 0.89 8.4 8.9 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Fmp27_WPPW PF10359.4 EFX05923.1 - 4.1 5.7 19.0 0.24 9.7 4.5 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF1664 PF07889.7 EFX05923.1 - 5.8 6.7 10.0 5.2 6.8 1.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 EFX05923.1 - 5.9 7.3 14.9 21 5.5 5.0 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF695 PF05117.7 EFX05923.1 - 6.1 6.7 6.7 4.8 7.0 0.4 2.5 2 1 1 3 3 2 0 Family of unknown function (DUF695) TPR_MLP1_2 PF07926.7 EFX05923.1 - 7.6 6.2 31.2 3.2 7.5 8.8 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein TarH PF02203.10 EFX05923.1 - 8.2 6.2 15.4 9.2 6.0 0.9 2.1 1 1 1 2 2 2 0 Tar ligand binding domain homologue Striatin PF08232.7 EFX05923.1 - 8.3 6.7 20.8 9.9e+02 -0.1 14.4 2.3 1 1 0 1 1 1 0 Striatin family WXG100 PF06013.7 EFX05923.1 - 9.1 6.3 15.4 5.2 7.1 0.3 3.9 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF724 PF05266.9 EFX05923.1 - 9.8 5.7 23.3 3.5 7.2 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Epimerase PF01370.16 EFX05924.1 - 1.1e-43 149.4 0.7 7.7e-43 146.6 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EFX05924.1 - 1.5e-16 60.0 0.1 2.9e-16 59.1 0.0 1.4 1 1 1 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.10 EFX05924.1 - 4e-14 52.1 0.0 2.1e-13 49.8 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 EFX05924.1 - 2e-13 49.9 0.0 3.1e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EFX05924.1 - 2.1e-09 36.5 0.3 4.7e-09 35.3 0.0 1.7 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EFX05924.1 - 2.6e-05 24.3 0.0 5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Zn_clus PF00172.13 EFX05925.1 - 2.4e-07 30.5 6.2 4.5e-07 29.6 4.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF413 PF04219.7 EFX05925.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF FAD_binding_1 PF00667.15 EFX05927.1 - 1.3e-61 207.8 0.0 6.6e-61 205.5 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.16 EFX05927.1 - 6.8e-12 45.9 0.0 4.2e-11 43.3 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain POR PF01558.13 EFX05927.1 - 4.8e-05 23.3 0.0 9.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase RRM_1 PF00076.17 EFX05928.1 - 8e-44 147.1 0.4 7.2e-22 76.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX05928.1 - 1.5e-34 117.7 0.1 1.2e-18 66.7 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.1 EFX05928.1 - 1.1e-24 86.5 0.5 3.7e-24 84.7 0.4 2.0 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_5 PF13893.1 EFX05928.1 - 1.8e-19 69.3 0.0 3.4e-09 36.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EFX05928.1 - 0.00095 18.9 0.1 0.007 16.1 0.0 2.3 2 1 0 2 2 2 1 RNA binding motif Bromodomain PF00439.20 EFX05929.1 - 8e-19 67.3 0.0 1.8e-18 66.1 0.0 1.7 1 0 0 1 1 1 1 Bromodomain BTB PF00651.26 EFX05929.1 - 9.6e-05 22.3 0.0 0.00019 21.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain PQ-loop PF04193.9 EFX05930.1 - 1.1e-21 76.1 3.3 9.9e-13 47.4 0.2 2.9 4 0 0 4 4 4 2 PQ loop repeat DUF4131 PF13567.1 EFX05930.1 - 6.6 6.1 14.7 1.2 8.5 2.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) RNA12 PF10443.4 EFX05931.1 - 1.3e-149 498.3 0.0 3e-119 398.3 0.0 2.1 2 0 0 2 2 2 2 RNA12 protein RRM_1 PF00076.17 EFX05931.1 - 0.00011 21.7 0.0 0.00025 20.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX05931.1 - 0.00022 21.0 0.0 0.00057 19.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arch_ATPase PF01637.13 EFX05931.1 - 0.0012 18.6 0.0 0.0073 16.0 0.0 2.1 1 1 0 1 1 1 1 Archaeal ATPase DUF2487 PF10673.4 EFX05931.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) TLD PF07534.11 EFX05932.1 - 0.0018 18.2 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 TLD DnaJ PF00226.26 EFX05933.1 - 9e-25 86.1 0.3 9e-25 86.1 0.2 1.7 2 0 0 2 2 2 1 DnaJ domain PAT1 PF09770.4 EFX05933.1 - 0.033 12.4 18.9 0.036 12.3 13.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 YppG PF14179.1 EFX05933.1 - 0.16 12.5 23.0 0.42 11.2 15.9 1.8 1 0 0 1 1 1 0 YppG-like protein RR_TM4-6 PF06459.7 EFX05933.1 - 0.38 10.6 3.0 0.56 10.0 2.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Macoilin PF09726.4 EFX05933.1 - 8.4 4.5 11.1 11 4.2 7.7 1.1 1 0 0 1 1 1 0 Transmembrane protein Pro_isomerase PF00160.16 EFX05934.1 - 1.6e-46 158.3 0.0 2.5e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.10 EFX05934.1 - 0.068 13.1 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 U-box domain Abhydrolase_3 PF07859.8 EFX05935.1 - 9.4e-11 41.6 0.0 1e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold BIR PF00653.16 EFX05936.1 - 2.6e-44 149.4 4.4 2.9e-21 75.6 0.0 2.3 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain WD40 PF00400.27 EFX05937.1 - 4.1e-45 150.0 17.1 8.2e-12 44.5 0.2 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 EFX05937.1 - 2.6e-08 33.7 11.4 0.057 13.1 0.1 4.3 2 2 1 4 4 4 4 Transcription factor IIIC subunit delta N-term Nup160 PF11715.3 EFX05937.1 - 0.095 10.8 3.0 0.21 9.6 0.3 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 IKI3 PF04762.7 EFX05937.1 - 0.24 9.1 4.1 1.9 6.1 0.0 2.1 2 0 0 2 2 2 0 IKI3 family TAF4 PF05236.9 EFX05938.1 - 1.2e-10 41.1 0.0 1.6e-09 37.4 0.0 2.7 2 1 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family PLAC8 PF04749.12 EFX05939.1 - 1.6e-22 80.0 15.4 2.2e-22 79.6 10.7 1.2 1 0 0 1 1 1 1 PLAC8 family DIT1_PvcA PF05141.7 EFX05940.1 - 2.7e-78 263.1 0.0 3.9e-78 262.5 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein AMP-binding PF00501.23 EFX05940.1 - 2.3e-11 42.7 0.2 5.8e-07 28.2 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.20 EFX05940.1 - 6.8e-08 32.6 0.0 1.7e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Transferase PF02458.10 EFX05940.1 - 5e-06 25.2 0.0 0.0038 15.7 0.0 2.8 3 0 0 3 3 3 2 Transferase family PWI PF01480.12 EFX05941.1 - 6.1e-10 39.0 0.2 1.4e-09 37.8 0.1 1.6 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.17 EFX05941.1 - 0.15 11.6 0.0 1.1 8.9 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RGS PF00615.14 EFX05942.1 - 2e-08 34.3 0.0 3.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PAS_9 PF13426.1 EFX05942.1 - 1.4e-07 31.8 0.0 5.2e-05 23.5 0.0 3.5 3 0 0 3 3 3 1 PAS domain PAS_8 PF13188.1 EFX05942.1 - 0.087 12.7 0.0 46 4.0 0.0 3.5 4 0 0 4 4 4 0 PAS domain PIR PF00399.14 EFX05943.1 - 7.1e-06 25.1 36.3 0.00033 19.8 1.3 6.4 4 1 0 4 4 4 4 Yeast PIR protein repeat LIM PF00412.17 EFX05944.1 - 4.7e-22 77.8 15.6 1.8e-09 37.5 2.4 4.0 4 0 0 4 4 4 3 LIM domain Sec3_C PF09763.4 EFX05944.1 - 0.25 9.4 0.1 0.47 8.5 0.1 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec3 TF_Zn_Ribbon PF08271.7 EFX05944.1 - 0.33 10.3 3.8 8.8 5.7 0.0 3.7 3 0 0 3 3 3 0 TFIIB zinc-binding DUF2321 PF10083.4 EFX05944.1 - 0.43 10.0 3.8 0.18 11.3 0.3 2.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Band_7 PF01145.20 EFX05945.1 - 7.8e-32 110.6 0.5 1.4e-31 109.7 0.4 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family DLH PF01738.13 EFX05945.1 - 5.2e-18 65.1 0.0 9.5e-17 61.0 0.0 2.8 2 1 0 2 2 2 1 Dienelactone hydrolase family Methyltransf_11 PF08241.7 EFX05945.1 - 1.4e-12 47.8 0.0 5.7e-12 45.9 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05945.1 - 6.3e-12 45.7 0.0 2.1e-11 44.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05945.1 - 8.4e-08 32.2 4.3 2.7e-07 30.6 0.1 3.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX05945.1 - 1.2e-07 31.5 0.0 2.6e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05945.1 - 6.8e-07 29.8 0.2 6.5e-06 26.6 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05945.1 - 1.6e-06 28.4 0.0 7.2e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX05945.1 - 0.0001 21.5 0.0 0.00041 19.5 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFX05945.1 - 0.017 14.6 0.0 0.043 13.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Band_7_1 PF13421.1 EFX05945.1 - 0.05 13.1 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family MTS PF05175.9 EFX05945.1 - 0.085 12.2 0.0 0.26 10.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase small domain MSA-2c PF12238.3 EFX05946.1 - 0.55 9.8 4.0 0.61 9.7 2.7 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF3597 PF12200.3 EFX05946.1 - 2.4 8.5 6.9 3 8.2 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DUF2360 PF10152.4 EFX05946.1 - 9 6.5 8.3 9.5 6.4 5.7 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Glyco_transf_22 PF03901.12 EFX05947.1 - 1.1e-84 284.9 17.3 1.3e-84 284.6 12.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family UvrD_C PF13361.1 EFX05948.1 - 2.5e-74 250.8 0.1 3.5e-74 250.3 0.1 1.2 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 EFX05948.1 - 3.7e-60 203.8 0.0 9e-59 199.3 0.0 2.2 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 EFX05948.1 - 2.2e-13 50.2 0.0 8.3e-13 48.3 0.0 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 EFX05948.1 - 2.9e-11 42.9 0.7 2.9e-11 42.9 0.5 2.4 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 EFX05948.1 - 4.4e-06 26.4 7.5 5.5e-05 22.8 0.0 2.8 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.13 EFX05948.1 - 4.7e-06 26.2 0.0 0.009 15.5 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.1 EFX05948.1 - 0.0003 20.2 0.1 0.0015 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF563 PF04577.9 EFX05948.1 - 0.13 12.1 0.1 15 5.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF563) Abhydrolase_6 PF12697.2 EFX05950.1 - 2.7e-13 50.3 0.1 4.9e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05950.1 - 2e-09 37.3 0.0 3.7e-09 36.4 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX05950.1 - 7.1e-07 29.0 0.0 2.5e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 EFX05950.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Cutinase PF01083.17 EFX05950.1 - 0.13 11.9 0.0 0.37 10.4 0.0 1.7 2 0 0 2 2 2 0 Cutinase Ribosomal_L36 PF00444.13 EFX05951.1 - 3.9e-20 71.5 14.4 1.1e-19 70.0 10.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L36 DUF4636 PF15468.1 EFX05951.1 - 0.23 10.8 1.4 0.28 10.5 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Ubie_methyltran PF01209.13 EFX05953.1 - 7.4e-64 215.0 0.0 1e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EFX05953.1 - 5.9e-12 45.4 0.0 8.1e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX05953.1 - 3.1e-11 43.5 0.0 5.1e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX05953.1 - 5.6e-11 42.7 0.0 4.4e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX05953.1 - 2.2e-10 40.8 0.0 3.7e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX05953.1 - 8.3e-09 36.0 0.0 1.7e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX05953.1 - 1.3e-08 34.7 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX05953.1 - 1.3e-05 25.2 0.2 2.8e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX05953.1 - 0.019 14.3 0.0 0.067 12.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_8 PF05148.10 EFX05953.1 - 0.061 12.9 0.0 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_24 PF13578.1 EFX05953.1 - 0.092 13.5 0.0 0.18 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain WD40 PF00400.27 EFX05954.1 - 0.067 13.1 11.1 0.88 9.5 1.8 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Sugar_tr PF00083.19 EFX05955.1 - 5.1e-48 163.7 20.3 7e-48 163.3 14.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EFX05955.1 - 6.9e-17 61.1 35.7 6.9e-17 61.1 24.8 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily FtsX PF02687.16 EFX05955.1 - 0.007 16.1 2.7 0.007 16.1 1.9 3.9 4 1 0 4 4 4 1 FtsX-like permease family Usher PF00577.15 EFX05955.1 - 0.17 10.6 0.1 0.25 10.0 0.0 1.1 1 0 0 1 1 1 0 Outer membrane usher protein WD40 PF00400.27 EFX05956.1 - 5.1e-36 121.2 2.9 1.1e-08 34.6 0.0 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 EFX05956.1 - 0.0015 16.7 1.6 0.26 9.3 0.0 3.0 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.9 EFX05956.1 - 0.16 10.7 0.0 0.29 9.8 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region DHHA2 PF02833.9 EFX05957.1 - 2.6e-21 76.1 0.0 3.8e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 EFX05957.1 - 2.8e-11 43.2 0.0 4.4e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 DHH family NAD_binding_2 PF03446.10 EFX05960.1 - 3.4e-37 127.7 1.6 6.5e-37 126.8 1.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EFX05960.1 - 1e-32 112.7 0.6 2.5e-32 111.4 0.1 1.8 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase OCD_Mu_crystall PF02423.10 EFX05960.1 - 7.5e-09 34.7 0.0 1.3e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.12 EFX05960.1 - 2.3e-07 31.1 2.0 4.7e-06 26.9 0.0 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.17 EFX05960.1 - 8e-05 23.1 0.1 0.0002 21.8 0.1 1.6 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_Gly3P_dh_N PF01210.18 EFX05960.1 - 0.00023 20.9 2.1 0.00066 19.4 0.0 2.3 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.13 EFX05960.1 - 0.00042 20.3 0.6 0.0015 18.4 0.0 2.1 2 0 0 2 2 2 1 TrkA-N domain 3HCDH_N PF02737.13 EFX05960.1 - 0.00082 19.0 4.1 0.015 14.9 0.1 3.0 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EFX05960.1 - 0.0054 16.8 0.5 0.01 15.9 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ECH PF00378.15 EFX05960.1 - 0.23 10.5 0.1 0.23 10.5 0.0 2.0 3 0 0 3 3 3 0 Enoyl-CoA hydratase/isomerase family Rad4 PF03835.10 EFX05961.1 - 6e-27 93.8 0.7 1.2e-26 92.9 0.0 1.8 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EFX05961.1 - 4.1e-23 80.8 0.0 7.5e-23 80.0 0.0 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 EFX05961.1 - 2.1e-19 68.7 0.0 4.3e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EFX05961.1 - 2.8e-08 33.9 1.6 5.7e-08 32.9 0.1 2.4 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 EFX05961.1 - 0.00014 22.0 0.6 0.0016 18.6 0.3 2.8 2 1 0 2 2 2 1 Transglutaminase-like superfamily CCDC66 PF15236.1 EFX05961.1 - 0.013 15.1 0.1 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Mon1 PF03164.9 EFX05962.1 - 9.6e-108 360.4 0.0 2e-107 359.4 0.0 1.5 1 1 0 1 1 1 1 Trafficking protein Mon1 Brix PF04427.13 EFX05963.1 - 5.6e-35 120.7 0.0 7.8e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Brix domain CENP-T PF15511.1 EFX05963.1 - 0.11 11.7 20.5 0.17 11.0 14.2 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T PAS_10 PF13596.1 EFX05963.1 - 0.15 12.3 0.0 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 PAS domain RRN3 PF05327.6 EFX05963.1 - 0.31 9.0 2.9 0.44 8.6 2.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RCC1_2 PF13540.1 EFX05965.1 - 4.7e-27 92.9 22.2 1.3e-07 31.0 1.3 4.3 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 EFX05965.1 - 3e-26 91.3 13.9 6e-11 42.3 0.1 6.7 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Reg_prop PF07494.6 EFX05965.1 - 0.04 13.9 0.0 15 6.0 0.0 3.1 3 0 0 3 3 3 0 Two component regulator propeller Colicin_Ia PF11504.3 EFX05965.1 - 0.083 12.7 0.2 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Colicin Ia Fungal_trans PF04082.13 EFX05966.1 - 5.5e-12 45.1 0.0 9.2e-12 44.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX05966.1 - 5.8e-07 29.3 9.6 1.3e-06 28.2 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IGPD PF00475.13 EFX05967.1 - 5e-60 201.5 0.8 8.9e-60 200.7 0.5 1.4 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Arb1 PF09692.5 EFX05968.1 - 1.2e-52 179.0 1.2 5.5e-47 160.4 0.0 2.5 2 1 1 3 3 3 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 ABC2_membrane PF01061.19 EFX05969.1 - 3.3e-37 127.6 20.8 3.3e-37 127.6 14.4 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 EFX05969.1 - 1.7e-24 86.6 0.0 2.9e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EFX05969.1 - 4.8e-10 39.8 0.0 1.8e-09 37.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.2 EFX05969.1 - 8.5e-10 38.1 17.9 8.5e-10 38.1 12.4 2.4 2 0 0 2 2 2 1 ABC-2 family transporter protein hEGF PF12661.2 EFX05969.1 - 1e-05 25.2 23.0 0.0079 16.2 2.1 4.2 3 0 0 3 3 3 2 Human growth factor-like EGF AAA_25 PF13481.1 EFX05969.1 - 0.00013 21.4 0.0 0.023 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EFX05969.1 - 0.0033 16.5 0.0 1.1 8.2 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFX05969.1 - 0.0062 16.0 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain EGF_2 PF07974.8 EFX05969.1 - 0.0078 16.3 9.6 0.0078 16.3 6.6 3.7 4 0 0 4 4 3 2 EGF-like domain DUF258 PF03193.11 EFX05969.1 - 0.023 13.8 0.0 0.058 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 EFX05969.1 - 0.041 13.5 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 EFX05969.1 - 0.045 14.0 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EFX05969.1 - 0.055 14.2 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EFX05969.1 - 0.065 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFX05969.1 - 0.072 12.9 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 EFX05969.1 - 0.1 12.5 0.0 0.39 10.6 0.0 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit PDR_CDR PF06422.7 EFX05969.1 - 0.11 12.2 0.4 0.8 9.4 0.0 2.5 2 0 0 2 2 2 0 CDR ABC transporter AAA_16 PF13191.1 EFX05969.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.1 EFX05969.1 - 0.21 11.5 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain EGF PF00008.22 EFX05969.1 - 0.62 10.0 16.8 0.59 10.1 0.1 3.7 3 0 0 3 3 3 0 EGF-like domain HET PF06985.6 EFX05970.1 - 3.2e-27 95.3 1.6 6.7e-26 91.1 1.9 2.5 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) AP_endonuc_2 PF01261.19 EFX05970.1 - 0.017 14.4 0.1 4.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Stirrup PF09061.1 EFX05970.1 - 0.041 13.7 0.2 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 Stirrup DUF1617 PF07761.7 EFX05970.1 - 0.19 11.8 0.9 0.33 10.9 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1617) DUF1338 PF07063.8 EFX05971.1 - 1.9e-76 257.0 0.0 2.2e-76 256.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) ADH_N PF08240.7 EFX05972.1 - 1.6e-31 108.3 0.4 1.6e-31 108.3 0.3 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX05972.1 - 2.1e-24 85.5 0.7 2.1e-24 85.5 0.5 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX05972.1 - 1.7e-07 32.1 0.2 4.8e-07 30.7 0.0 1.8 1 1 1 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 EFX05972.1 - 0.0013 19.3 0.0 0.0025 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain AlaDh_PNT_C PF01262.16 EFX05972.1 - 0.01 15.4 0.6 0.017 14.6 0.5 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.9 EFX05972.1 - 0.023 14.0 0.1 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.9 EFX05972.1 - 0.068 11.6 0.3 0.1 11.0 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein tRNA-synt_2b PF00587.20 EFX05973.1 - 7.5e-22 77.7 0.0 1.4e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ProRS-C_1 PF09180.6 EFX05973.1 - 1.7e-18 66.3 0.1 3.5e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.15 EFX05973.1 - 3.4e-15 55.7 0.0 8.2e-15 54.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Actin PF00022.14 EFX05974.1 - 2.2e-131 437.9 0.0 2.5e-131 437.7 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EFX05974.1 - 0.00015 20.4 0.0 0.0047 15.5 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein MutL PF13941.1 EFX05974.1 - 0.095 11.0 0.0 0.14 10.4 0.0 1.1 1 0 0 1 1 1 0 MutL protein Ribosom_S12_S23 PF00164.20 EFX05975.1 - 8.7e-42 141.4 0.6 1.1e-41 141.1 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Glyco_hydro_53 PF07745.8 EFX05976.1 - 2.9e-103 345.1 0.0 3.3e-103 344.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 ArfGap PF01412.13 EFX05978.1 - 3.7e-37 126.6 0.5 8.7e-37 125.4 0.4 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF3275 PF11679.3 EFX05978.1 - 0.072 12.7 0.2 0.072 12.7 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3275) Rad51 PF08423.6 EFX05979.1 - 1.8e-19 69.6 0.0 3.7e-19 68.6 0.0 1.4 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.1 EFX05979.1 - 1.2e-07 31.3 0.1 2.4e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EFX05979.1 - 0.00023 20.3 0.1 0.0058 15.7 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein KaiC PF06745.8 EFX05979.1 - 0.00078 18.6 0.0 0.0021 17.2 0.0 1.7 2 0 0 2 2 2 1 KaiC ABC_tran PF00005.22 EFX05979.1 - 0.0053 17.0 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 EFX05979.1 - 0.044 13.9 0.0 0.099 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain PAT1 PF09770.4 EFX05979.1 - 0.99 7.5 8.2 1.2 7.2 5.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 E1-E2_ATPase PF00122.15 EFX05980.1 - 3.7e-50 170.0 1.7 8.9e-50 168.8 0.0 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 EFX05980.1 - 1.8e-36 126.5 2.1 4.4e-36 125.3 1.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 EFX05980.1 - 1.2e-18 67.0 4.5 8.7e-11 41.8 0.1 4.0 4 0 0 4 4 4 2 Heavy-metal-associated domain HAD PF12710.2 EFX05980.1 - 2.5e-15 57.1 0.0 6.8e-15 55.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EFX05980.1 - 6.2e-05 22.6 0.0 0.0002 21.0 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EFX05980.1 - 0.02 15.1 0.0 0.045 13.9 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase zf-HC2 PF13490.1 EFX05980.1 - 0.063 13.2 1.7 0.2 11.6 1.1 1.9 1 0 0 1 1 1 0 Putative zinc-finger Thioredoxin PF00085.15 EFX05982.1 - 7.1e-26 89.9 0.0 8.2e-26 89.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EFX05982.1 - 1.4e-07 31.7 0.1 1.3e-06 28.5 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EFX05982.1 - 6.7e-07 29.3 0.0 5.4e-06 26.4 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 EFX05982.1 - 2.1e-05 24.1 0.1 2.4e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.1 EFX05982.1 - 0.00025 21.0 0.0 0.0004 20.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 EFX05982.1 - 0.00034 20.1 0.0 0.00043 19.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 EFX05982.1 - 0.00075 19.1 0.0 0.00086 18.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family HyaE PF07449.6 EFX05982.1 - 0.0071 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.19 EFX05982.1 - 0.05 13.5 0.6 0.17 11.9 0.4 2.0 1 1 0 1 1 1 0 Glutaredoxin Thioredoxin_4 PF13462.1 EFX05982.1 - 0.1 12.5 0.1 1.5 8.8 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin NPV_P10 PF05531.7 EFX05983.1 - 1.2 9.4 5.5 1.4 9.2 0.1 3.5 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein CENP-N PF05238.8 EFX05984.1 - 7.4e-123 410.5 0.0 8.5e-123 410.3 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like PNRC PF15365.1 EFX05984.1 - 0.037 14.0 0.0 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator Zn_clus PF00172.13 EFX05985.1 - 7.3e-05 22.5 8.7 0.00013 21.7 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.8 EFX05985.1 - 1.5 8.6 8.7 2.3 8.0 6.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Acetyltransf_7 PF13508.1 EFX05986.1 - 3.3e-08 33.5 0.0 7.1e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX05986.1 - 5.1e-07 29.6 0.0 1.5e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 EFX05986.1 - 1.4e-05 24.9 0.0 8e-05 22.4 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX05986.1 - 2.4e-05 23.9 0.0 0.00033 20.3 0.0 2.3 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.1 EFX05986.1 - 0.0022 18.1 0.1 0.032 14.3 0.0 2.7 2 1 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EFX05986.1 - 0.032 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Fungal_trans PF04082.13 EFX05987.1 - 5.3e-31 107.4 0.2 3.4e-30 104.7 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF2433 PF10360.4 EFX05989.1 - 2.7e-50 170.0 0.0 5.1e-50 169.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) PAT1 PF09770.4 EFX05989.1 - 0.79 7.8 14.2 1.2 7.3 9.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2360 PF10152.4 EFX05989.1 - 1.4 9.2 11.5 0.36 11.0 4.5 2.4 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Actin PF00022.14 EFX05990.1 - 2.9e-19 68.7 0.0 7.5e-12 44.3 0.0 3.3 3 1 0 3 3 3 3 Actin YihI PF04220.7 EFX05990.1 - 0.12 11.6 0.1 0.22 10.8 0.1 1.3 1 0 0 1 1 1 0 Der GTPase activator (YihI) SUR7 PF06687.7 EFX05991.1 - 6e-10 39.0 0.1 8.9e-10 38.4 0.1 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EFX05991.1 - 0.088 12.6 4.9 0.16 11.8 3.4 1.3 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 CAAD PF14159.1 EFX05991.1 - 1.7 8.3 4.2 9.2 5.9 0.3 2.4 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Hist_deacetyl PF00850.14 EFX05992.1 - 5.8e-58 196.6 0.1 8.7e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DUF1774 PF08611.5 EFX05992.1 - 8.3e-25 86.7 4.9 1.7e-24 85.8 3.4 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1774) ACPS PF01648.15 EFX05992.1 - 1.2e-07 31.5 0.0 4.6e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily MFS_1 PF07690.11 EFX05993.1 - 2.5e-27 95.5 22.2 6.1e-23 81.1 1.2 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Utp21 PF04192.7 EFX05995.1 - 3.3e-70 235.8 0.0 4.4e-70 235.4 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 EFX05995.1 - 5.4e-18 64.1 21.9 3.5e-05 23.5 0.2 8.8 9 0 0 9 9 9 4 WD domain, G-beta repeat PQQ_2 PF13360.1 EFX05995.1 - 2.6e-07 30.3 1.5 0.085 12.3 0.0 3.9 3 2 1 4 4 4 3 PQQ-like domain Cytochrom_D1 PF02239.11 EFX05995.1 - 7.4e-05 21.2 0.0 0.022 13.0 0.0 2.4 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.3 EFX05995.1 - 0.00059 18.0 0.9 0.31 9.1 0.1 3.3 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EFX05995.1 - 0.29 9.8 0.0 0.65 8.6 0.0 1.6 1 0 0 1 1 1 0 Nup133 N terminal like Glyco_hydro_18 PF00704.23 EFX05996.1 - 5.7e-66 223.2 0.2 8e-66 222.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 EFX05996.1 - 1.2e-08 34.8 35.8 1.4e-08 34.5 6.6 2.9 2 1 0 2 2 2 2 Chitin recognition protein Abhydrolase_6 PF12697.2 EFX05997.1 - 2.7e-24 86.3 1.8 5.5e-24 85.2 1.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX05997.1 - 5.5e-12 45.6 0.1 1.2e-11 44.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX05997.1 - 1.1e-10 41.4 0.6 5.4e-08 32.6 0.2 2.7 2 1 0 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.13 EFX05997.1 - 0.0023 17.2 0.1 0.31 10.2 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family UPF0227 PF05728.7 EFX05997.1 - 0.02 14.5 0.0 4.9 6.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.3 EFX05997.1 - 0.024 14.4 0.1 0.75 9.6 0.0 3.1 4 0 0 4 4 4 0 Putative lysophospholipase Esterase PF00756.15 EFX05997.1 - 0.028 13.8 0.3 0.55 9.6 0.1 2.2 2 0 0 2 2 2 0 Putative esterase PGAP1 PF07819.8 EFX05997.1 - 0.031 13.8 0.0 0.047 13.2 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_2 PF02230.11 EFX05997.1 - 0.034 13.5 0.5 4.3 6.7 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.5 EFX05997.1 - 0.11 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein DUF2048 PF09752.4 EFX05997.1 - 0.2 10.4 1.7 0.36 9.6 1.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) p450 PF00067.17 EFX05998.1 - 6.9e-33 113.8 0.0 2.9e-28 98.5 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 Sld5 PF05916.6 EFX05999.1 - 7.9e-09 35.7 0.2 1.4e-08 35.0 0.1 1.4 1 0 0 1 1 1 1 GINS complex protein Nup54 PF13874.1 EFX05999.1 - 0.12 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Aminotran_3 PF00202.16 EFX06000.1 - 4.6e-77 259.1 0.2 5.7e-77 258.8 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III CRAL_TRIO PF00650.15 EFX06001.1 - 8.9e-24 83.7 0.0 1.4e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EFX06001.1 - 1.7e-08 34.4 0.0 3.9e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF3818 PF12825.2 EFX06002.1 - 6.9e-35 120.3 0.0 6.4e-25 87.5 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 EFX06002.1 - 3.4e-26 91.4 0.0 6.2e-26 90.6 0.0 1.4 1 0 0 1 1 1 1 PX-associated GAS2 PF02187.12 EFX06003.1 - 6.1e-05 22.7 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Inp1 PF12634.2 EFX06004.1 - 5.6e-36 123.3 0.0 1.4e-35 122.1 0.0 1.6 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 CytochromB561_N PF09786.4 EFX06004.1 - 3.4 6.0 7.9 4 5.7 1.4 2.1 2 0 0 2 2 2 0 Cytochrome B561, N terminal Inositol_P PF00459.20 EFX06006.1 - 2e-50 171.6 2.9 3.6e-50 170.7 2.0 1.4 1 1 0 1 1 1 1 Inositol monophosphatase family Pyridox_oxidase PF01243.15 EFX06007.1 - 0.048 13.6 0.0 13 5.9 0.0 3.1 3 1 0 3 3 3 0 Pyridoxamine 5'-phosphate oxidase NAD_binding_6 PF08030.7 EFX06007.1 - 0.091 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EFX06007.1 - 0.094 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain CorA PF01544.13 EFX06008.1 - 0.0016 17.5 1.1 0.0016 17.5 0.7 2.4 1 1 1 2 2 2 1 CorA-like Mg2+ transporter protein COX4_pro_2 PF07835.7 EFX06008.1 - 0.026 14.5 0.4 0.054 13.4 0.2 1.5 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV HD PF01966.17 EFX06010.1 - 4.1e-06 26.8 0.0 7e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 HD domain AA_permease_2 PF13520.1 EFX06011.1 - 3.4e-82 276.2 29.3 4.3e-82 275.9 20.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX06011.1 - 4.6e-22 78.0 26.7 5.8e-22 77.6 18.5 1.1 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.8 EFX06011.1 - 2.7 6.5 10.6 6.7 5.2 2.7 3.3 3 0 0 3 3 3 0 Spore germination protein Cupin_8 PF13621.1 EFX06012.1 - 6.3e-57 192.9 0.0 8.4e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 EFX06012.1 - 0.00038 19.8 0.5 0.2 10.8 0.0 2.2 2 0 0 2 2 2 2 Cupin superfamily protein WD40 PF00400.27 EFX06013.1 - 2.6e-24 84.1 10.7 1e-09 37.8 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EFX06013.1 - 2.3e-18 65.8 0.0 5.8e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex Nup160 PF11715.3 EFX06013.1 - 0.012 13.7 1.1 0.019 13.1 0.8 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 CAP59_mtransfer PF11735.3 EFX06014.1 - 2.1e-61 207.2 0.0 3e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 IBR PF01485.16 EFX06015.1 - 3.7 7.4 39.5 0.067 13.0 5.4 3.6 2 1 0 3 3 3 0 IBR domain Alpha-amylase PF00128.19 EFX06016.1 - 6.9e-99 331.1 0.0 1e-98 330.6 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.13 EFX06016.1 - 0.015 15.4 0.1 0.044 13.9 0.0 1.9 2 0 0 2 2 2 0 Alpha amylase, C-terminal all-beta domain MMR_HSR1 PF01926.18 EFX06018.1 - 7.5e-16 58.1 0.0 3.7e-15 55.9 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFX06018.1 - 8.5e-07 28.5 0.0 5.8e-06 25.8 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 EFX06018.1 - 0.0002 21.2 0.0 0.002 17.9 0.0 2.3 1 1 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 EFX06018.1 - 0.0033 16.7 0.0 0.031 13.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_29 PF13555.1 EFX06018.1 - 0.0057 16.1 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 EFX06018.1 - 0.014 14.6 0.1 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 EFX06018.1 - 0.017 15.4 1.2 0.028 14.6 0.1 1.9 2 0 0 2 2 2 0 ABC transporter AAA_21 PF13304.1 EFX06018.1 - 0.064 13.2 0.1 0.093 12.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain DUF1284 PF06935.6 EFX06018.1 - 0.079 13.1 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1284) Miro PF08477.8 EFX06018.1 - 0.11 13.0 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein AAA_18 PF13238.1 EFX06018.1 - 0.31 11.3 0.8 0.67 10.2 0.2 1.9 2 0 0 2 2 2 0 AAA domain OB_NTP_bind PF07717.11 EFX06019.1 - 1.7e-26 92.2 0.0 3.9e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFX06019.1 - 1.1e-22 79.9 1.2 2.3e-22 78.9 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFX06019.1 - 2.3e-10 40.1 0.0 5.3e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.18 EFX06019.1 - 5e-10 39.3 0.5 1e-09 38.3 0.3 1.5 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.24 EFX06019.1 - 3.3e-06 26.6 0.1 6.1e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 EFX06019.1 - 2.1e-05 23.5 0.0 4.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 EFX06019.1 - 3.3e-05 24.0 0.1 0.0001 22.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX06019.1 - 0.001 18.8 0.1 0.0029 17.3 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 EFX06019.1 - 0.021 14.7 0.1 0.2 11.5 0.1 2.3 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 EFX06019.1 - 0.037 13.8 0.0 6.4 6.5 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Myosin_head PF00063.16 EFX06019.1 - 0.038 12.0 0.1 0.06 11.3 0.0 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) DUF2075 PF09848.4 EFX06019.1 - 0.041 12.8 0.3 0.22 10.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.11 EFX06019.1 - 0.041 13.0 0.1 0.1 11.8 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.1 EFX06019.1 - 0.082 12.8 0.5 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Sigma54_activ_2 PF14532.1 EFX06019.1 - 0.11 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Herpes_ori_bp PF02399.10 EFX06019.1 - 0.29 9.0 0.1 0.48 8.3 0.1 1.2 1 0 0 1 1 1 0 Origin of replication binding protein ABC_tran PF00005.22 EFX06019.1 - 0.31 11.3 1.8 0.76 10.0 0.1 2.4 2 1 0 2 2 2 0 ABC transporter DUF1604 PF07713.8 EFX06020.1 - 4.5e-38 128.9 0.8 4.5e-38 128.9 0.6 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.18 EFX06020.1 - 1.2e-06 28.1 2.3 6.6e-06 25.8 0.7 2.7 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 EFX06020.1 - 0.01 15.6 0.2 0.01 15.6 0.1 3.4 3 1 0 3 3 3 1 DExH-box splicing factor binding site MbtH PF03621.8 EFX06020.1 - 0.076 12.3 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 MbtH-like protein FB_lectin PF07367.6 EFX06021.1 - 2.4e-27 95.2 0.0 2.9e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Fungal fruit body lectin tRNA-synt_2 PF00152.15 EFX06022.1 - 5.9e-84 281.7 0.1 8.2e-84 281.2 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EFX06022.1 - 1.5e-09 37.5 0.1 3.5e-09 36.3 0.1 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EFX06022.1 - 7.9e-09 35.0 0.1 0.00058 19.1 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) Mpp10 PF04006.7 EFX06022.1 - 0.1 10.9 2.7 0.15 10.3 1.9 1.2 1 0 0 1 1 1 0 Mpp10 protein UCR_Fe-S_N PF10399.4 EFX06022.1 - 0.1 11.7 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal GATase PF00117.23 EFX06023.1 - 3.1e-10 39.8 0.0 4.2e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I HAD PF12710.2 EFX06024.1 - 6.2e-11 42.8 0.0 1.2e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Epimerase PF01370.16 EFX06024.1 - 8.9e-07 28.5 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family HAD_2 PF13419.1 EFX06024.1 - 0.0085 16.3 0.0 0.16 12.1 0.0 2.6 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase RmlD_sub_bind PF04321.12 EFX06024.1 - 0.013 14.3 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Myotoxins PF00819.12 EFX06025.1 - 0.13 12.3 0.3 0.37 10.8 0.2 1.8 1 0 0 1 1 1 0 Myotoxin TSA PF03249.8 EFX06025.1 - 1.9 6.9 8.4 3.2 6.2 5.8 1.3 1 0 0 1 1 1 0 Type specific antigen BAF1_ABF1 PF04684.8 EFX06025.1 - 2 7.1 5.6 3.9 6.2 3.9 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor EAP30 PF04157.11 EFX06026.1 - 2.2e-52 177.4 0.7 3e-52 177.0 0.5 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 EFX06026.1 - 7.1e-27 93.0 0.0 1.1e-26 92.4 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.15 EFX06026.1 - 3.9e-05 23.0 0.0 8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 GRAM domain zf-Sec23_Sec24 PF04810.10 EFX06026.1 - 0.014 14.9 5.8 0.015 14.8 0.3 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-RanBP PF00641.13 EFX06026.1 - 0.018 14.1 0.8 0.018 14.1 0.6 2.6 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others GCC2_GCC3 PF07699.8 EFX06026.1 - 0.82 9.2 2.4 0.76 9.3 0.2 1.9 2 0 0 2 2 2 0 GCC2 and GCC3 Se-cys_synth_N PF12390.3 EFX06027.1 - 0.045 13.8 0.3 0.26 11.3 0.0 2.4 2 0 0 2 2 2 0 Selenocysteine synthase N terminal HHH PF00633.18 EFX06027.1 - 0.076 12.7 0.0 0.24 11.1 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.1 EFX06027.1 - 0.1 12.7 0.1 0.43 10.7 0.0 2.2 2 2 0 2 2 2 0 Helix-hairpin-helix domain CAP PF00188.21 EFX06028.1 - 1.5e-14 54.5 4.0 2.1e-14 54.0 2.7 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rootletin PF15035.1 EFX06029.1 - 0.11 12.4 2.1 0.17 11.8 1.5 1.3 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DNA_topoisoIV PF00521.15 EFX06030.1 - 2.3e-116 389.1 0.0 7.3e-116 387.4 0.0 1.9 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 EFX06030.1 - 3.4e-32 111.0 1.3 7.8e-32 109.8 0.9 1.6 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 EFX06030.1 - 3e-12 46.3 0.0 1.1e-11 44.5 0.0 2.0 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 EFX06030.1 - 1.5e-08 34.3 0.0 4.1e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Abhydrolase_6 PF12697.2 EFX06031.1 - 9.4e-10 38.7 2.9 4.8e-07 29.8 0.3 2.9 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX06031.1 - 1.2e-06 28.3 0.3 1.4e-05 24.8 0.2 2.4 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EFX06031.1 - 7.6e-06 25.6 1.4 0.0068 16.0 0.0 2.6 2 1 0 2 2 2 2 alpha/beta hydrolase fold DUF3089 PF11288.3 EFX06031.1 - 0.0012 18.0 0.0 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Thioesterase PF00975.15 EFX06031.1 - 0.006 16.8 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.16 EFX06031.1 - 0.022 14.0 4.9 4.5 6.4 3.1 2.7 2 1 0 2 2 2 0 Prolyl oligopeptidase family COesterase PF00135.23 EFX06031.1 - 0.031 12.9 0.8 1.6 7.3 0.1 2.4 3 0 0 3 3 3 0 Carboxylesterase family BAAT_C PF08840.6 EFX06031.1 - 0.067 12.8 0.0 8.7 5.9 0.0 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.20 EFX06031.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Inositol_P PF00459.20 EFX06032.1 - 1.2e-62 211.6 0.1 2e-62 210.9 0.1 1.3 1 1 0 1 1 1 1 Inositol monophosphatase family DUF1680 PF07944.7 EFX06033.1 - 6.4e-21 74.2 0.1 7e-20 70.7 0.0 2.3 2 0 0 2 2 2 1 Putative glycosyl hydrolase of unknown function (DUF1680) Prenyltrans_1 PF13243.1 EFX06033.1 - 0.014 15.4 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 Prenyltransferase-like YvfG PF09628.5 EFX06033.1 - 0.091 12.9 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 0 YvfG protein Cys_Met_Meta_PP PF01053.15 EFX06035.1 - 4.1e-142 473.0 0.0 4.6e-142 472.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EFX06035.1 - 1.2e-09 37.7 0.0 3.6e-09 36.1 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 EFX06035.1 - 2.9e-09 36.3 0.1 4.1e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EFX06035.1 - 9.2e-07 27.9 0.1 1.8e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EFX06035.1 - 1.7e-06 27.4 0.1 3.9e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.11 EFX06035.1 - 0.0025 16.5 0.0 0.0034 16.1 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein SLA_LP_auto_ag PF05889.8 EFX06035.1 - 0.003 16.1 0.1 0.0047 15.4 0.0 1.2 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Met_gamma_lyase PF06838.6 EFX06035.1 - 0.0092 14.3 0.0 0.013 13.8 0.0 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase IMPDH PF00478.20 EFX06035.1 - 0.1 11.4 0.1 0.17 10.7 0.1 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain MGS PF02142.17 EFX06035.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 MGS-like domain XPG_I PF00867.13 EFX06036.1 - 2e-24 85.4 0.0 4.4e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EFX06036.1 - 3.2e-08 33.7 0.0 6.7e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain Lactonase PF10282.4 EFX06037.1 - 2e-13 50.1 0.0 5.7e-13 48.6 0.0 1.7 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Aldedh PF00171.17 EFX06038.1 - 1.4e-162 541.2 1.1 1.6e-162 541.0 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 EFX06038.1 - 0.00064 19.0 0.0 0.015 14.5 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) Fungal_trans PF04082.13 EFX06040.1 - 1.8e-27 95.8 0.1 2.8e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06040.1 - 7.8e-09 35.3 13.5 1.5e-08 34.4 9.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dus PF01207.12 EFX06041.1 - 2.3e-44 151.4 0.1 2.3e-44 151.4 0.1 2.1 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) DUF1903 PF08991.5 EFX06043.1 - 1.9e-15 56.7 1.6 2.3e-15 56.5 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) zf-primase PF09329.6 EFX06043.1 - 0.05 13.2 0.3 0.085 12.4 0.2 1.3 1 0 0 1 1 1 0 Primase zinc finger CHCH PF06747.8 EFX06043.1 - 0.083 12.8 2.7 0.13 12.2 1.8 1.2 1 0 0 1 1 1 0 CHCH domain CN_hydrolase PF00795.17 EFX06044.1 - 1.7e-19 69.8 0.0 4.5e-19 68.5 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Spb1_C PF07780.7 EFX06045.1 - 9.2e-69 231.2 36.5 9.2e-69 231.2 25.3 4.1 3 2 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.14 EFX06045.1 - 7.2e-54 182.5 0.1 1.5e-53 181.4 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.3 EFX06045.1 - 1.2e-51 174.3 9.1 1.2e-51 174.3 6.3 4.5 4 1 0 4 4 4 1 Domain of unknown function (DUF3381) HDAC4_Gln PF12203.3 EFX06045.1 - 2.2 8.2 15.6 4.9 7.1 6.4 2.9 2 0 0 2 2 2 0 Glutamine rich N terminal domain of histone deacetylase 4 RRN7 PF11781.3 EFX06046.1 - 7.2e-07 28.6 3.3 1.2e-06 27.8 2.3 1.4 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 Corona_nucleoca PF00937.13 EFX06046.1 - 0.00069 18.6 6.3 0.001 18.1 4.3 1.2 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein DUF1509 PF07420.6 EFX06046.1 - 0.0011 18.3 4.7 0.0019 17.5 3.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1509) Hepatitis_core PF00906.15 EFX06046.1 - 8.4 6.0 8.9 3.5 7.2 4.3 1.6 2 0 0 2 2 2 0 Hepatitis core antigen GSDH PF07995.6 EFX06047.1 - 4.9e-07 29.1 0.0 2.9e-06 26.6 0.0 2.3 1 1 1 2 2 2 1 Glucose / Sorbosone dehydrogenase NHL PF01436.16 EFX06047.1 - 0.091 12.7 0.0 29 4.8 0.0 3.4 3 0 0 3 3 3 0 NHL repeat DUF3852 PF12963.2 EFX06047.1 - 0.12 12.4 0.2 0.83 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Peptidase_S10 PF00450.17 EFX06048.1 - 7.3e-59 199.9 0.0 1.6e-58 198.8 0.0 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase RNA_pol_I_A49 PF06870.7 EFX06049.1 - 6.4e-72 242.2 0.1 8.1e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Ceramidase_alk PF04734.8 EFX06050.1 - 2.2e-254 845.4 0.2 6e-254 843.9 0.1 1.6 1 1 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase KilA-N PF04383.8 EFX06051.1 - 0.0024 17.4 0.0 0.005 16.4 0.0 1.5 1 0 0 1 1 1 1 KilA-N domain DUF3608 PF12257.3 EFX06053.1 - 3.7e-74 249.1 0.5 1.9e-72 243.5 0.4 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 EFX06053.1 - 2.1e-27 94.6 0.0 5.1e-27 93.4 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) HSP70 PF00012.15 EFX06054.1 - 8e-229 760.5 4.2 9e-229 760.3 2.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EFX06054.1 - 1.9e-15 56.3 0.3 4.4e-14 51.8 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EFX06054.1 - 0.00037 20.1 0.0 0.00069 19.2 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF743 PF05332.6 EFX06054.1 - 0.063 13.2 0.1 0.39 10.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF743) FtsA PF14450.1 EFX06054.1 - 0.22 11.3 2.1 8 6.3 0.0 3.3 3 1 0 3 3 3 0 Cell division protein FtsA Ank_2 PF12796.2 EFX06055.1 - 5.9e-63 209.2 24.0 4.1e-10 39.8 0.0 14.7 9 3 6 15 15 15 14 Ankyrin repeats (3 copies) Ank PF00023.25 EFX06055.1 - 6.9e-36 120.2 43.3 2.1e-05 24.0 0.0 22.1 25 1 1 26 26 26 10 Ankyrin repeat Ank_4 PF13637.1 EFX06055.1 - 3.3e-29 100.7 21.4 0.00056 20.3 0.0 16.7 16 4 3 19 19 19 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX06055.1 - 1.1e-25 87.1 24.3 0.0067 16.5 0.0 21.4 25 2 1 26 26 26 4 Ankyrin repeat Ank_5 PF13857.1 EFX06055.1 - 4.2e-20 71.3 9.5 6.9e-07 29.3 0.0 12.0 13 1 1 14 14 14 3 Ankyrin repeats (many copies) U-box PF04564.10 EFX06056.1 - 1.1e-21 76.5 0.0 2.4e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 U-box domain TPR_11 PF13414.1 EFX06056.1 - 1.1e-17 63.4 3.7 7.3e-15 54.3 0.0 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 EFX06056.1 - 3.7e-09 35.8 1.4 0.0015 18.2 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX06056.1 - 2.1e-06 27.4 0.9 0.11 12.8 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFX06056.1 - 2.3e-06 26.9 4.1 0.36 10.5 1.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX06056.1 - 0.00033 21.0 0.4 0.33 11.6 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 EFX06056.1 - 0.00069 20.2 0.2 0.57 10.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX06056.1 - 0.00073 19.8 0.9 1 9.7 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-Nse PF11789.3 EFX06056.1 - 0.002 17.5 0.0 0.1 12.1 0.0 2.6 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TPR_12 PF13424.1 EFX06056.1 - 0.0048 16.7 3.2 1.7 8.6 0.4 2.6 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EFX06056.1 - 0.12 12.2 1.2 32 4.6 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat eIF-1a PF01176.14 EFX06057.1 - 2.4e-09 36.4 0.0 1.5e-07 30.7 0.0 2.4 1 1 0 1 1 1 1 Translation initiation factor 1A / IF-1 zf-U1 PF06220.7 EFX06058.1 - 4.3e-08 32.5 0.2 7e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 U1 zinc finger zf-Dof PF02701.10 EFX06058.1 - 0.14 12.1 0.6 0.26 11.2 0.4 1.5 1 0 0 1 1 1 0 Dof domain, zinc finger UQ_con PF00179.21 EFX06059.1 - 1.1e-12 47.5 0.1 3.2e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Complex1_LYR PF05347.10 EFX06059.1 - 1.6e-06 27.7 0.0 4.3e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EFX06059.1 - 3.5e-06 27.1 0.0 8.6e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Complex1_LYR-like RWD PF05773.17 EFX06059.1 - 0.018 14.9 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 RWD domain GED PF02212.13 EFX06059.1 - 0.24 11.3 1.4 0.48 10.3 1.0 1.5 1 0 0 1 1 1 0 Dynamin GTPase effector domain Fructosamin_kin PF03881.9 EFX06060.1 - 1.5e-19 70.0 0.0 1.9e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 EFX06060.1 - 0.081 12.6 0.0 0.22 11.2 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Toxin_7 PF05980.7 EFX06061.1 - 0.45 10.5 9.0 1.2 9.2 6.2 1.7 1 0 0 1 1 1 0 Toxin 7 CytochromB561_N PF09786.4 EFX06061.1 - 2.8 6.3 18.5 3.3 6.0 12.8 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal KAR9 PF08580.5 EFX06061.1 - 8.1 4.5 16.8 9.9 4.2 11.7 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF3348 PF11828.3 EFX06064.1 - 0.00062 19.2 0.7 0.00062 19.2 0.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3348) WD40 PF00400.27 EFX06066.1 - 7.4e-26 89.0 2.6 9.4e-09 34.8 0.0 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat DUF3639 PF12341.3 EFX06066.1 - 3.2e-08 33.3 3.4 3.2e-08 33.3 2.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3639) eIF2A PF08662.6 EFX06066.1 - 4.2e-05 23.3 0.0 0.0015 18.3 0.0 2.5 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 EFX06066.1 - 0.00017 20.5 0.0 0.00092 18.1 0.0 1.8 1 1 1 2 2 2 1 Coatomer WD associated region IKI3 PF04762.7 EFX06066.1 - 0.0076 14.1 0.2 0.016 13.0 0.1 1.5 1 1 1 2 2 2 1 IKI3 family TruB_C PF09142.6 EFX06066.1 - 0.013 15.0 0.0 0.099 12.2 0.0 2.5 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal MMS1_N PF10433.4 EFX06066.1 - 0.37 8.8 0.0 1.1 7.2 0.0 1.7 1 1 1 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term MRP-L47 PF06984.8 EFX06067.1 - 1e-23 83.0 0.0 1.6e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NACHT PF05729.7 EFX06068.1 - 7.1e-11 42.0 0.0 1.8e-10 40.7 0.0 1.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 EFX06068.1 - 0.0015 18.6 0.0 0.0093 16.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX06068.1 - 0.0019 19.0 0.2 0.0045 17.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFX06068.1 - 0.0045 16.1 0.0 0.0074 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 NB-ARC PF00931.17 EFX06068.1 - 0.0047 15.8 0.0 0.0069 15.2 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 EFX06068.1 - 0.0055 16.7 0.4 0.038 13.9 0.0 2.3 2 1 1 3 3 3 1 AAA ATPase domain Hpr_kinase_C PF07475.7 EFX06068.1 - 0.0082 15.4 0.0 2.5 7.3 0.0 2.5 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain AAA_14 PF13173.1 EFX06068.1 - 0.02 14.8 0.0 0.046 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EFX06068.1 - 0.02 15.1 0.1 0.046 14.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.15 EFX06068.1 - 0.045 12.4 0.0 0.069 11.8 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit KaiC PF06745.8 EFX06068.1 - 0.048 12.7 0.0 0.098 11.7 0.0 1.5 1 0 0 1 1 1 0 KaiC ArgK PF03308.11 EFX06068.1 - 0.054 12.2 0.0 0.095 11.4 0.0 1.3 1 0 0 1 1 1 0 ArgK protein RNA_helicase PF00910.17 EFX06068.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 EFX06068.1 - 0.058 12.8 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain MobB PF03205.9 EFX06068.1 - 0.072 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 EFX06068.1 - 0.081 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 EFX06068.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_25 PF13481.1 EFX06068.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cohesin_load PF10345.4 EFX06069.1 - 5e-114 381.7 0.0 5e-114 381.7 0.0 2.7 2 1 0 2 2 2 1 Cohesin loading factor RabGAP-TBC PF00566.13 EFX06070.1 - 4.8e-46 156.9 0.0 9.5e-46 155.9 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IncA PF04156.9 EFX06070.1 - 0.0039 16.8 17.5 0.0086 15.6 3.0 3.2 3 0 0 3 3 3 2 IncA protein DUF1640 PF07798.6 EFX06070.1 - 0.48 10.4 5.3 0.27 11.2 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) WD40 PF00400.27 EFX06071.1 - 9.6e-22 76.0 10.9 1.2e-08 34.4 0.0 6.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Methyltransf_23 PF13489.1 EFX06072.1 - 1.1e-17 64.2 0.0 1.7e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX06072.1 - 1.8e-12 47.5 0.0 3.9e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ABC_tran PF00005.22 EFX06072.1 - 1.7e-11 44.5 0.0 3.2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter Methyltransf_31 PF13847.1 EFX06072.1 - 2.3e-08 33.7 0.0 3.6e-07 29.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06072.1 - 2e-07 31.5 0.0 3.6e-06 27.5 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX06072.1 - 5.4e-06 25.6 0.0 3.2e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFX06072.1 - 4e-05 24.0 0.0 0.00025 21.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX06072.1 - 0.0001 22.5 0.0 0.00028 21.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX06072.1 - 0.0027 17.7 0.0 0.037 14.0 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain AAA_22 PF13401.1 EFX06072.1 - 0.0031 17.6 0.0 0.0056 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Methyltransf_4 PF02390.12 EFX06072.1 - 0.0068 15.4 0.0 0.021 13.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 EFX06072.1 - 0.0068 15.7 0.0 0.032 13.5 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase small domain AAA_29 PF13555.1 EFX06072.1 - 0.0098 15.3 0.1 0.026 14.0 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Miro PF08477.8 EFX06072.1 - 0.014 15.9 0.0 0.024 15.1 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein FtsJ PF01728.14 EFX06072.1 - 0.028 14.3 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase AAA_10 PF12846.2 EFX06072.1 - 0.035 13.5 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain DUF87 PF01935.12 EFX06072.1 - 0.059 13.1 0.2 0.17 11.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 GidB PF02527.10 EFX06072.1 - 0.068 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G FtsK_SpoIIIE PF01580.13 EFX06072.1 - 0.07 12.6 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family PRK PF00485.13 EFX06072.1 - 0.082 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Methyltransf_16 PF10294.4 EFX06072.1 - 0.092 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase AAA_21 PF13304.1 EFX06072.1 - 0.092 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Methyltransf_2 PF00891.13 EFX06072.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Lipl32 PF12103.3 EFX06072.1 - 0.099 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order Methyltransf_PK PF05891.7 EFX06072.1 - 0.11 11.8 0.1 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Med4 PF10018.4 EFX06073.1 - 1.2e-33 116.0 2.1 2.4e-33 115.1 1.5 1.5 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 MRP-L20 PF12824.2 EFX06073.1 - 7.7 6.4 9.3 5.4 6.9 4.7 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit L20 DUF1517 PF07466.6 EFX06076.1 - 0.026 13.5 3.3 0.038 12.9 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) DAP10 PF07213.6 EFX06076.1 - 0.031 14.0 0.1 0.031 14.0 0.1 2.0 2 0 0 2 2 2 0 DAP10 membrane protein TMEM154 PF15102.1 EFX06076.1 - 0.13 11.9 0.3 0.31 10.7 0.2 1.6 1 1 0 1 1 1 0 TMEM154 protein family USP8_dimer PF08969.6 EFX06077.1 - 0.028 14.3 1.0 0.036 14.0 0.1 1.6 2 0 0 2 2 2 0 USP8 dimerisation domain Mannosyl_trans2 PF04188.8 EFX06078.1 - 1.3e-59 202.3 0.6 1.9e-59 201.7 0.4 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V)) YTH PF04146.10 EFX06078.1 - 9.7e-37 125.6 0.3 1.5e-36 125.0 0.2 1.3 1 0 0 1 1 1 1 YT521-B-like domain Mo25 PF08569.6 EFX06079.1 - 5e-115 384.0 0.0 5.9e-115 383.8 0.0 1.0 1 0 0 1 1 1 1 Mo25-like Herpes_UL6 PF01763.11 EFX06080.1 - 0.00024 19.4 0.1 0.00039 18.7 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus UL6 like Sin_N PF04801.8 EFX06083.1 - 1.6e-18 66.8 0.0 1.8e-09 36.9 0.0 2.4 3 0 0 3 3 3 2 Sin-like protein conserved region Tom37_C PF11801.3 EFX06083.1 - 8.7 6.1 5.6 34 4.2 3.9 1.9 1 1 0 1 1 1 0 Tom37 C-terminal domain Aha1_N PF09229.6 EFX06084.1 - 8.8e-35 119.5 0.1 1.7e-34 118.5 0.1 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 EFX06084.1 - 2.1e-17 63.3 0.5 4.5e-17 62.2 0.3 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Sec16_N PF12935.2 EFX06084.1 - 0.026 14.4 2.1 0.039 13.8 1.5 1.2 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus DUF4297 PF14130.1 EFX06084.1 - 0.069 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4297) Polyketide_cyc2 PF10604.4 EFX06084.1 - 0.082 13.0 4.4 0.072 13.2 0.7 2.1 2 0 0 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport DNA_photolyase PF00875.13 EFX06084.1 - 0.1 12.3 0.4 0.58 9.8 0.2 2.0 2 0 0 2 2 2 0 DNA photolyase DUF3752 PF12572.3 EFX06085.1 - 3.6e-27 95.3 37.4 2.1e-15 57.1 5.6 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3752) BiPBP_C PF06832.7 EFX06085.1 - 0.043 13.7 0.1 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family Pro_isomerase PF00160.16 EFX06086.1 - 7.5e-44 149.6 0.5 9.8e-44 149.2 0.4 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TFIIA PF03153.8 EFX06087.1 - 2.2e-77 261.4 8.6 3.1e-77 261.0 6.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 EFX06087.1 - 0.082 10.8 4.4 0.1 10.5 3.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 EFX06087.1 - 0.29 9.8 8.7 0.49 9.0 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.7 EFX06087.1 - 4.3 6.9 8.7 0.93 9.1 3.6 1.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Aldolase_II PF00596.16 EFX06088.1 - 4.4e-37 127.4 0.0 6.7e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain NRDD PF13597.1 EFX06089.1 - 4.4e-192 638.9 0.0 5.2e-192 638.7 0.0 1.0 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Radical_SAM PF04055.16 EFX06089.1 - 3.7e-12 46.7 0.0 9.1e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 EFX06089.1 - 1.1e-09 38.3 0.2 1.8e-08 34.3 0.0 3.0 3 0 0 3 3 3 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EFX06089.1 - 2e-07 31.1 0.0 5.7e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain TDH PF03347.8 EFX06089.1 - 0.0024 17.4 0.0 0.0059 16.1 0.0 1.7 2 0 0 2 2 2 1 Vibrio thermostable direct hemolysin INCENP_N PF12178.3 EFX06089.1 - 0.11 12.0 0.0 1.5 8.4 0.0 2.6 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal Fer4_18 PF13746.1 EFX06089.1 - 0.23 11.9 3.7 9.4 6.7 0.6 2.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain Bromodomain PF00439.20 EFX06091.1 - 9.5e-38 128.0 0.2 3.5e-18 65.3 0.0 2.3 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 EFX06091.1 - 1.4e-12 47.3 0.0 2.5e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 BAH domain Aldo_ket_red PF00248.16 EFX06092.1 - 8.3e-68 228.2 0.0 9.5e-68 228.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ketoacyl-synt PF00109.21 EFX06093.1 - 1.2e-18 67.5 0.1 2.6e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.15 EFX06093.1 - 2.3e-17 62.8 0.0 5.5e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 EFX06093.1 - 2.3e-11 43.5 0.0 7.5e-11 41.9 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acetyltransf_3 PF13302.1 EFX06094.1 - 6.9e-24 84.6 0.0 8.6e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EFX06094.1 - 3.4e-06 26.9 0.0 5.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family eIF-5a PF01287.15 EFX06095.1 - 5.7e-26 90.2 1.8 8e-26 89.7 1.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 EFX06095.1 - 2.4e-05 23.8 0.8 6e-05 22.6 0.6 1.7 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 EFX06095.1 - 0.0044 16.8 0.4 0.021 14.7 0.0 2.1 3 0 0 3 3 3 1 Elongation factor P (EF-P) KOW-like domain Tmemb_14 PF03647.8 EFX06096.1 - 2.4e-25 88.7 5.9 2.8e-25 88.5 4.1 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2416 PF10315.4 EFX06096.1 - 0.0096 16.1 0.7 0.026 14.7 0.5 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2416) HupE_UreJ PF04955.7 EFX06096.1 - 0.076 12.3 1.7 0.11 11.7 1.2 1.3 1 1 0 1 1 1 0 HupE / UreJ protein DUF1427 PF07235.6 EFX06096.1 - 7.5 6.7 7.0 7.6 6.6 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1427) TFIIA PF03153.8 EFX06097.1 - 0.0053 16.7 5.5 0.0089 15.9 3.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.11 EFX06098.1 - 2.1e-25 89.2 44.3 1.4e-15 56.9 13.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 EFX06098.1 - 0.037 13.8 1.1 0.79 9.5 0.1 2.7 2 0 0 2 2 2 0 MFS_1 like family Claudin_2 PF13903.1 EFX06098.1 - 1.7 8.3 0.0 1.7 8.3 0.0 3.2 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Aminotran_5 PF00266.14 EFX06100.1 - 2.2e-06 26.7 0.0 4.9e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V NACHT PF05729.7 EFX06102.1 - 0.0015 18.2 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Leader_Trp PF08255.6 EFX06102.1 - 0.18 11.5 0.4 19 5.2 0.1 2.7 2 0 0 2 2 2 0 Trp-operon Leader Peptide DUF2011 PF09428.5 EFX06103.1 - 1.3e-16 60.6 10.1 3e-16 59.4 7.0 1.6 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Methyltransf_16 PF10294.4 EFX06104.1 - 4e-17 62.2 0.0 4.4e-16 58.8 0.0 2.1 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EFX06104.1 - 0.00012 22.5 0.2 0.00041 20.9 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX06104.1 - 0.00057 19.8 3.4 0.0018 18.2 1.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EFX06104.1 - 0.02 14.2 0.1 0.047 13.0 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 EFX06104.1 - 0.064 12.3 0.4 0.1 11.7 0.3 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Asp PF00026.18 EFX06105.1 - 2.4e-61 207.7 9.5 2.4e-61 207.7 6.6 1.4 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EFX06105.1 - 7.3e-07 29.2 1.6 7.3e-07 29.2 1.1 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EFX06105.1 - 0.041 13.4 0.0 0.16 11.5 0.0 2.0 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EFX06105.1 - 0.076 13.5 1.1 37 4.9 0.3 3.5 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.1 EFX06105.1 - 0.086 12.6 0.2 14 5.5 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Cation_efflux PF01545.16 EFX06106.1 - 3.9e-59 200.0 1.3 4.9e-59 199.7 0.9 1.0 1 0 0 1 1 1 1 Cation efflux family NicO PF03824.11 EFX06106.1 - 0.046 13.0 12.5 0.056 12.7 8.1 1.6 1 1 0 1 1 1 0 High-affinity nickel-transport protein Nicastrin PF05450.10 EFX06106.1 - 0.12 11.5 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Nicastrin Zip PF02535.17 EFX06106.1 - 0.85 8.5 32.7 45 2.9 22.6 2.8 1 1 0 1 1 1 0 ZIP Zinc transporter TP_methylase PF00590.15 EFX06107.1 - 7.3e-20 71.5 0.0 1.3e-19 70.7 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Fungal_trans PF04082.13 EFX06108.1 - 9.4e-25 86.9 0.1 4.4e-20 71.6 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06108.1 - 3.2e-09 36.5 8.4 5.5e-09 35.7 5.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pribosyltran PF00156.22 EFX06109.1 - 2e-12 46.9 0.2 1.2e-11 44.3 0.1 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain GATase_2 PF00310.16 EFX06109.1 - 1.5e-10 40.3 0.0 4.7e-06 25.5 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 EFX06109.1 - 3.2e-10 39.7 0.0 5.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EFX06109.1 - 8e-08 32.3 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain SPRY PF00622.23 EFX06111.1 - 4.4e-08 33.2 0.0 1.7e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 SPRY domain WD40 PF00400.27 EFX06112.1 - 1e-23 82.2 20.9 6.6e-07 28.9 0.2 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 EFX06112.1 - 2e-07 30.8 0.4 1.4e-05 24.8 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Pterin_bind PF00809.17 EFX06113.1 - 2.7e-62 209.8 0.3 4.6e-62 209.1 0.0 1.5 2 0 0 2 2 2 1 Pterin binding enzyme HPPK PF01288.15 EFX06113.1 - 1.6e-39 134.5 0.0 4.4e-39 133.1 0.0 1.8 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) tRNA-synt_2b PF00587.20 EFX06114.1 - 8.3e-35 119.9 0.0 1.1e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFX06114.1 - 3.3e-07 30.1 0.0 8.4e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain ABC2_membrane PF01061.19 EFX06115.1 - 4.3e-80 267.8 55.6 6.1e-43 146.4 16.1 2.9 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.7 EFX06115.1 - 4.4e-35 119.4 6.4 6.2e-30 102.9 0.0 3.5 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.22 EFX06115.1 - 3.1e-33 114.9 0.0 5.5e-16 59.1 0.0 2.5 3 0 0 3 3 2 2 ABC transporter ABC_trans_N PF14510.1 EFX06115.1 - 1.4e-21 76.3 0.0 5e-21 74.5 0.0 1.9 2 0 0 2 2 1 1 ABC-transporter extracellular N-terminal AAA_16 PF13191.1 EFX06115.1 - 1.7e-07 31.4 0.3 0.001 19.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 EFX06115.1 - 2.3e-07 30.3 0.0 0.00014 21.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 EFX06115.1 - 3.6e-05 23.3 0.7 0.0051 16.2 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ABC2_membrane_3 PF12698.2 EFX06115.1 - 5.4e-05 22.3 9.1 5.4e-05 22.3 6.3 3.1 2 2 1 3 3 3 1 ABC-2 family transporter protein AAA_33 PF13671.1 EFX06115.1 - 0.00028 20.7 0.1 0.014 15.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFX06115.1 - 0.00061 19.9 0.0 0.79 9.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 EFX06115.1 - 0.00085 18.5 0.1 0.0039 16.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX06115.1 - 0.001 19.2 0.1 0.76 9.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EFX06115.1 - 0.0011 18.3 0.7 0.048 13.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 EFX06115.1 - 0.0039 17.9 0.0 0.19 12.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX06115.1 - 0.0043 17.3 0.0 0.059 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EFX06115.1 - 0.0046 16.6 0.3 0.85 9.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.1 EFX06115.1 - 0.045 13.3 0.2 1.1 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.14 EFX06115.1 - 0.045 12.9 0.0 0.98 8.5 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.1 EFX06115.1 - 0.055 13.4 0.4 0.79 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 EFX06115.1 - 0.06 13.2 0.0 0.87 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 EFX06115.1 - 0.11 12.1 1.6 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Thymidylate_kin PF02223.12 EFX06115.1 - 0.11 11.8 0.3 4.4 6.6 0.0 3.1 3 1 0 3 3 3 0 Thymidylate kinase AAA_19 PF13245.1 EFX06115.1 - 0.18 11.5 9.2 1.3 8.7 0.2 3.0 3 0 0 3 3 2 0 Part of AAA domain AAA_24 PF13479.1 EFX06115.1 - 0.23 10.9 1.2 8.5 5.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 EFX06115.1 - 0.29 10.8 0.0 24 4.5 0.0 2.4 2 0 0 2 2 2 0 Archaeal ATPase PduV-EutP PF10662.4 EFX06115.1 - 0.43 10.0 2.1 3.9 6.9 0.2 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AMP-binding PF00501.23 EFX06116.1 - 9.9e-76 254.7 0.0 1.4e-75 254.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 EFX06116.1 - 2.2e-61 206.9 0.0 3.3e-61 206.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.20 EFX06116.1 - 3.3e-10 40.0 0.0 7.2e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 EFX06116.1 - 6.3e-09 35.6 0.0 1.1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 EFX06116.1 - 3.7e-08 34.1 0.0 2.1e-07 31.8 0.0 2.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.1 EFX06116.1 - 1.8e-05 24.8 0.0 0.00086 19.3 0.0 2.5 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX06116.1 - 0.00019 20.2 0.0 0.00034 19.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 EFX06116.1 - 0.051 13.4 0.4 0.2 11.5 0.2 2.2 1 1 0 1 1 1 0 short chain dehydrogenase MFS_1 PF07690.11 EFX06117.1 - 8.6e-11 41.1 24.3 8.6e-11 41.1 16.8 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX06117.1 - 3.1e-06 26.0 1.8 3.6e-06 25.8 0.2 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter Proteasome PF00227.21 EFX06118.1 - 1e-44 152.0 0.0 1.3e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 EFX06118.1 - 1.2e-13 50.0 0.1 3.1e-13 48.7 0.1 1.7 1 0 0 1 1 1 1 Proteasome beta subunits C terminal NDT80_PhoG PF05224.7 EFX06119.1 - 1.3e-30 106.8 0.0 1.3e-30 106.8 0.0 2.6 4 0 0 4 4 4 1 NDT80 / PhoG like DNA-binding family DnaJ PF00226.26 EFX06120.1 - 2.5e-14 52.7 0.4 7.3e-14 51.2 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain TGT PF01702.13 EFX06121.1 - 1.7e-85 286.0 0.0 2.2e-85 285.7 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.11 EFX06122.1 - 1.3e-40 139.2 26.3 1.3e-40 139.2 18.2 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFX06122.1 - 0.00037 20.0 2.3 0.0011 18.4 1.6 1.8 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Folate_carrier PF01770.13 EFX06122.1 - 1.4 7.3 12.1 0.061 11.8 2.9 2.3 2 2 1 3 3 3 0 Reduced folate carrier TauD PF02668.11 EFX06123.1 - 4.7e-49 167.3 0.0 6.1e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans_2 PF11951.3 EFX06124.1 - 5.1e-22 78.0 3.1 6.2e-22 77.7 2.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Carn_acyltransf PF00755.15 EFX06125.1 - 2e-168 561.1 0.0 1.4e-150 502.2 0.0 2.0 2 0 0 2 2 2 2 Choline/Carnitine o-acyltransferase MFS_1 PF07690.11 EFX06126.1 - 5.2e-25 87.8 21.3 6.5e-25 87.5 14.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Methyltransf_23 PF13489.1 EFX06127.1 - 1.2e-11 44.5 0.0 1.7e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX06127.1 - 3.7e-06 27.3 0.0 7e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX06127.1 - 0.00079 19.8 0.0 0.0063 16.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX06127.1 - 0.053 13.1 0.0 0.2 11.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Amidoligase_2 PF12224.3 EFX06128.1 - 9.2e-13 48.3 0.0 2.1e-12 47.1 0.0 1.5 1 1 0 1 1 1 1 Putative amidoligase enzyme FAA_hydrolase PF01557.13 EFX06129.1 - 8.2e-41 139.8 0.8 1.1e-40 139.4 0.1 1.5 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family SM-ATX PF14438.1 EFX06129.1 - 0.15 11.9 0.8 0.37 10.7 0.6 1.6 1 0 0 1 1 1 0 Ataxin 2 SM domain Fungal_trans PF04082.13 EFX06130.1 - 8.9e-23 80.4 0.1 2e-22 79.3 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06130.1 - 1.9e-06 27.6 10.4 3.6e-06 26.7 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MTP18 PF10558.4 EFX06131.1 - 4.7e-66 221.2 0.5 5.9e-66 220.9 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF3716 PF12511.3 EFX06132.1 - 1.5e-14 53.3 4.8 2.5e-14 52.6 3.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) CENP-C_C PF11699.3 EFX06132.1 - 0.0014 18.5 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Cwf_Cwc_15 PF04889.7 EFX06132.1 - 2.8 7.5 8.8 4.4 6.9 6.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Glyoxalase PF00903.20 EFX06133.1 - 8.7e-07 28.9 3.0 8.7e-07 28.9 2.1 2.3 2 2 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EFX06133.1 - 0.0013 19.2 3.9 0.048 14.2 0.3 2.3 2 0 0 2 2 2 2 Glyoxalase-like domain Sod_Cu PF00080.15 EFX06134.1 - 8.9e-16 58.3 0.0 1.3e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TraV PF09676.5 EFX06135.1 - 0.61 10.7 8.9 1.2 9.8 6.2 1.4 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Mucin PF01456.12 EFX06135.1 - 4.6 7.0 35.9 10 5.9 24.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Na_H_Exchanger PF00999.16 EFX06136.1 - 5.6e-70 235.7 39.8 8.7e-70 235.1 27.6 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family zf-C2H2_4 PF13894.1 EFX06137.1 - 0.0054 16.9 0.6 0.0054 16.9 0.4 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX06137.1 - 0.24 11.8 12.1 1.5 9.3 1.6 3.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type Peptidase_C48 PF02902.14 EFX06138.1 - 6e-05 22.7 0.1 0.0001 22.0 0.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Hydrolase_6 PF13344.1 EFX06139.1 - 1.8e-22 79.0 0.0 3.4e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EFX06139.1 - 9.3e-11 41.2 0.0 8.1e-10 38.2 0.0 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like SET PF00856.23 EFX06140.1 - 0.00031 21.0 0.0 0.19 12.0 0.0 2.9 1 1 0 1 1 1 1 SET domain Pkinase PF00069.20 EFX06141.1 - 1.4e-49 168.6 0.0 3.5e-34 118.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EFX06141.1 - 2.9e-21 75.7 0.0 6e-20 71.4 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX06141.1 - 2.2e-07 30.1 0.0 4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EFX06141.1 - 0.00034 20.4 0.1 0.021 14.5 0.0 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family Phyto-Amp PF15438.1 EFX06141.1 - 0.021 14.4 0.2 0.066 12.8 0.0 1.8 2 0 0 2 2 2 0 Antigenic membrane protein of phytoplasma MCLC PF05934.6 EFX06141.1 - 0.4 8.9 0.3 0.81 7.9 0.2 1.5 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) MFS_1 PF07690.11 EFX06143.1 - 3.8e-29 101.4 45.4 8.6e-29 100.3 31.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily APOC4 PF15119.1 EFX06143.1 - 0.14 12.1 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Apolipoprotein C4 DUF912 PF06024.7 EFX06143.1 - 0.14 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF2036 PF09724.4 EFX06145.1 - 2.7e-08 33.3 0.0 3.3e-08 33.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) Ribosomal_S2 PF00318.15 EFX06146.1 - 8e-43 146.1 0.0 4e-22 78.4 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Peptidase_S28 PF05577.7 EFX06147.1 - 3.6e-49 167.5 0.0 1.2e-48 165.7 0.0 1.7 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 EFX06147.1 - 0.00016 21.6 0.2 0.0026 17.6 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX06147.1 - 0.017 14.8 0.0 0.087 12.5 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX06147.1 - 0.048 12.8 0.1 0.1 11.7 0.1 1.5 1 1 0 1 1 1 0 Prolyl oligopeptidase family QCR10 PF09796.4 EFX06148.1 - 1.1e-21 76.2 0.3 1.3e-21 75.9 0.2 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) 2-Hacid_dh_C PF02826.14 EFX06149.1 - 5.5e-39 133.1 0.0 1.5e-38 131.7 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX06149.1 - 2.3e-23 82.1 0.0 3.2e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.7 EFX06149.1 - 0.00017 21.0 0.0 0.00046 19.5 0.0 1.7 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.12 EFX06149.1 - 0.00079 19.8 0.4 0.009 16.4 0.0 2.5 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent XdhC_C PF13478.1 EFX06149.1 - 0.0096 16.2 0.0 0.032 14.5 0.0 1.9 2 0 0 2 2 2 1 XdhC Rossmann domain NAD_binding_10 PF13460.1 EFX06149.1 - 0.02 14.8 0.5 0.18 11.7 0.1 2.5 2 1 0 2 2 2 0 NADH(P)-binding AdoHcyase_NAD PF00670.16 EFX06149.1 - 0.023 14.5 0.4 0.095 12.5 0.3 1.9 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AlaDh_PNT_C PF01262.16 EFX06149.1 - 0.043 13.3 2.8 4.2 6.9 0.9 2.8 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Flavin_Reduct PF01613.13 EFX06149.1 - 0.065 13.0 0.1 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Flavin reductase like domain ThiF PF00899.16 EFX06149.1 - 0.082 12.7 3.4 1.2 8.9 1.7 2.4 2 0 0 2 2 2 0 ThiF family Pro_isomerase PF00160.16 EFX06150.1 - 3.7e-49 166.9 0.3 1.4e-48 165.0 0.0 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.27 EFX06150.1 - 7.6e-13 47.8 0.4 2.5e-07 30.2 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.3 EFX06150.1 - 0.0062 14.7 0.1 1.3 7.1 0.0 2.6 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Fungal_trans PF04082.13 EFX06151.1 - 2.5e-19 69.1 0.0 3.9e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06151.1 - 0.19 11.6 4.6 0.32 10.9 3.2 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_3 PF13738.1 EFX06152.1 - 4.4e-11 43.2 0.0 6.4e-09 36.1 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX06152.1 - 1.8e-07 29.8 1.1 0.029 12.5 0.1 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EFX06152.1 - 1.2e-06 28.4 0.2 7.1e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX06152.1 - 0.0025 16.7 1.9 2.3 7.0 0.0 3.8 2 1 1 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFX06152.1 - 0.012 15.3 0.4 3.6 7.3 0.0 3.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding Malic_M PF03949.10 EFX06152.1 - 0.029 13.9 0.0 0.18 11.3 0.0 2.0 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain Thi4 PF01946.12 EFX06152.1 - 0.21 10.6 0.0 11 4.9 0.0 2.3 2 0 0 2 2 2 0 Thi4 family Abhydrolase_1 PF00561.15 EFX06153.1 - 3.4e-45 154.3 0.0 8.1e-45 153.1 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EFX06153.1 - 6.8e-13 49.0 5.4 2.1e-11 44.1 3.8 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX06153.1 - 0.0015 18.3 0.1 0.83 9.4 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 EFX06153.1 - 0.026 14.4 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DnaJ PF00226.26 EFX06154.1 - 2.1e-11 43.3 0.1 2.1e-11 43.3 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain Nop53 PF07767.6 EFX06154.1 - 1.6 7.6 25.6 2.8 6.8 17.7 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Borrelia_P83 PF05262.6 EFX06154.1 - 5.5 5.1 18.1 7.2 4.7 12.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Myb_DNA-bind_2 PF08914.6 EFX06155.1 - 1.3e-13 50.5 5.2 1.6e-13 50.1 0.3 2.4 2 0 0 2 2 2 1 Rap1 Myb domain Rap1-DNA-bind PF09197.5 EFX06155.1 - 1.9e-10 41.2 1.9 5.8e-08 33.2 0.2 2.9 2 0 0 2 2 2 2 Rap1, DNA-binding ARID PF01388.16 EFX06155.1 - 0.0052 16.6 0.0 0.014 15.2 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain EmrE PF13536.1 EFX06156.1 - 0.02 15.0 5.5 0.02 15.0 3.8 1.8 1 1 1 2 2 2 0 Multidrug resistance efflux transporter UPF0546 PF10639.4 EFX06156.1 - 0.024 14.4 1.1 0.035 13.9 0.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0546 EamA PF00892.15 EFX06156.1 - 0.052 13.5 10.1 0.075 13.0 6.6 1.6 1 1 0 1 1 1 0 EamA-like transporter family SNF2_N PF00176.18 EFX06157.1 - 3.7e-22 78.5 0.0 5.7e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX06157.1 - 0.00019 21.1 0.0 0.00084 19.1 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.1 EFX06157.1 - 0.02 14.6 2.4 0.02 14.6 1.7 2.2 2 1 0 2 2 2 0 zinc-RING finger domain OTU PF02338.14 EFX06158.1 - 1.6e-11 44.8 0.0 2.5e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 EFX06158.1 - 0.21 10.9 0.1 0.61 9.4 0.0 1.7 2 0 0 2 2 2 0 Peptidase C65 Otubain Clp1 PF06807.9 EFX06160.1 - 4.5e-22 78.7 0.0 7e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 Mito_carr PF00153.22 EFX06162.1 - 6.3e-48 160.4 7.5 4.5e-15 55.1 0.2 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein SR-25 PF10500.4 EFX06162.1 - 0.0016 17.9 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Methyltransf_26 PF13659.1 EFX06162.1 - 0.03 14.3 0.6 0.067 13.2 0.2 1.8 1 1 0 1 1 1 0 Methyltransferase domain Acyl_transf_3 PF01757.17 EFX06163.1 - 1.9e-27 96.0 18.3 5.3e-27 94.5 12.7 1.7 1 1 0 1 1 1 1 Acyltransferase family BTK PF00779.14 EFX06163.1 - 0.11 12.0 0.0 15 5.2 0.0 2.6 2 0 0 2 2 2 0 BTK motif WD40 PF00400.27 EFX06164.1 - 1.8e-35 119.4 2.8 1.5e-09 37.4 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Sof1 PF04158.9 EFX06164.1 - 3.1e-31 107.2 11.3 9.2e-31 105.7 7.9 1.8 2 0 0 2 2 2 1 Sof1-like domain eIF2A PF08662.6 EFX06164.1 - 4.3e-05 23.2 0.2 0.02 14.6 0.0 3.0 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Arylsulfotran_2 PF14269.1 EFX06164.1 - 5e-05 22.5 0.1 0.0019 17.3 0.1 2.6 2 1 1 3 3 3 1 Arylsulfotransferase (ASST) DUF3312 PF11768.3 EFX06164.1 - 0.0002 19.7 0.0 0.12 10.6 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3312) BBS2_Mid PF14783.1 EFX06164.1 - 0.00022 20.9 0.0 0.84 9.4 0.0 4.3 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.11 EFX06164.1 - 0.032 12.5 0.1 0.81 7.9 0.0 2.5 2 1 1 3 3 3 0 Cytochrome D1 heme domain Ribonuc_red_lgC PF02867.10 EFX06165.1 - 5e-223 741.5 0.0 6.9e-223 741.0 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 EFX06165.1 - 2.2e-23 81.8 0.0 7.7e-23 80.1 0.0 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 EFX06165.1 - 3.3e-17 62.6 0.1 1.3e-16 60.7 0.0 2.1 2 0 0 2 2 2 1 ATP cone domain Ribosomal_L40e PF01020.12 EFX06166.1 - 2.1e-20 72.0 10.6 2.2e-20 71.9 7.4 1.0 1 0 0 1 1 1 1 Ribosomal L40e family zinc_ribbon_2 PF13240.1 EFX06166.1 - 0.062 12.8 1.7 0.97 9.0 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 EFX06166.1 - 0.21 11.4 3.1 0.36 10.6 2.1 1.5 1 1 0 1 1 1 0 Double zinc ribbon DEAD PF00270.24 EFX06167.1 - 1.2e-42 145.2 0.0 2.4e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EFX06167.1 - 4.2e-25 87.0 0.1 9.4e-25 85.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EFX06167.1 - 2.8e-20 71.9 0.0 6.7e-20 70.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EFX06167.1 - 0.0023 16.8 0.0 0.0046 15.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EFX06167.1 - 0.16 11.7 0.0 0.16 11.7 0.0 3.4 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit Exo5 PF09810.4 EFX06168.1 - 3.2e-96 322.3 0.0 3.9e-96 322.0 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.2 EFX06168.1 - 1.2e-05 24.7 0.2 0.14 11.5 0.0 3.0 2 1 0 2 2 2 2 PD-(D/E)XK nuclease superfamily Fungal_trans PF04082.13 EFX06169.1 - 7.3e-33 113.5 0.0 1.3e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06169.1 - 6.1e-07 29.2 12.3 1.2e-06 28.3 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rad10 PF03834.9 EFX06170.1 - 0.019 14.6 0.0 0.23 11.1 0.0 2.3 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Ras PF00071.17 EFX06172.1 - 4.5e-41 139.9 0.0 8.8e-41 138.9 0.0 1.4 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EFX06172.1 - 7.3e-15 55.5 0.0 1e-14 55.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX06172.1 - 4.1e-11 42.4 0.0 8.5e-11 41.4 0.0 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EFX06172.1 - 0.00015 20.9 0.0 0.00019 20.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EFX06172.1 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.1 EFX06172.1 - 0.002 17.9 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 EFX06172.1 - 0.0029 17.0 0.0 0.081 12.4 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 EFX06172.1 - 0.011 14.9 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Arch_ATPase PF01637.13 EFX06172.1 - 0.015 15.0 0.1 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 Archaeal ATPase AAA_22 PF13401.1 EFX06172.1 - 0.016 15.3 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFX06172.1 - 0.023 14.3 0.0 0.07 12.7 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.1 EFX06172.1 - 0.034 14.1 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 EFX06172.1 - 0.044 14.0 0.0 0.079 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF258 PF03193.11 EFX06172.1 - 0.054 12.6 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 EFX06172.1 - 0.065 12.7 1.7 0.11 12.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_28 PF13521.1 EFX06172.1 - 0.13 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 EFX06172.1 - 0.21 10.2 0.0 0.35 9.5 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit YhjQ PF06564.7 EFX06173.1 - 0.052 12.8 0.0 0.069 12.5 0.0 1.1 1 0 0 1 1 1 0 YhjQ protein SH3BP5 PF05276.9 EFX06174.1 - 0.088 12.1 1.7 0.14 11.4 1.1 1.2 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) bZIP_1 PF00170.16 EFX06174.1 - 0.24 11.4 8.9 0.38 10.7 5.3 1.9 2 1 1 3 3 3 0 bZIP transcription factor DAGK_cat PF00781.19 EFX06175.1 - 3e-08 33.1 0.0 5.7e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain MFS_1 PF07690.11 EFX06176.1 - 4.3e-23 81.5 14.5 4.9e-23 81.4 10.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3437 PF11919.3 EFX06177.1 - 6.9e-25 86.5 0.0 2e-24 85.1 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) HEAT PF02985.17 EFX06177.1 - 0.031 14.3 3.4 9 6.6 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat GntP_permease PF02447.11 EFX06177.1 - 0.89 7.9 0.0 1.4 7.3 0.0 1.2 1 0 0 1 1 1 0 GntP family permease TEA PF01285.13 EFX06178.1 - 1.4e-18 67.2 0.0 1.4e-18 67.2 0.0 4.3 4 0 0 4 4 4 1 TEA/ATTS domain family Hid1 PF12722.2 EFX06178.1 - 8.3 3.9 12.9 4.2 4.9 2.2 2.3 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DUF1308 PF07000.6 EFX06179.1 - 3.3e-30 104.9 0.0 4.4e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) Iso_dh PF00180.15 EFX06180.1 - 5.1e-97 324.9 0.0 7.3e-97 324.4 0.0 1.2 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CTP_transf_1 PF01148.15 EFX06184.1 - 4.2e-18 65.9 5.2 8.4e-14 51.8 0.4 2.1 1 1 1 2 2 2 2 Cytidylyltransferase family DUF2413 PF10310.4 EFX06184.1 - 3.8 6.2 7.8 5.8 5.6 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) MitMem_reg PF13012.1 EFX06185.1 - 2.7e-37 127.3 0.0 6.5e-37 126.1 0.0 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 EFX06185.1 - 8.2e-27 93.2 0.0 1.5e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Cut8_N PF14482.1 EFX06187.1 - 0.045 13.7 4.9 0.21 11.6 3.4 2.2 1 0 0 1 1 1 0 Cut8 proteasome-binding domain Transferase PF02458.10 EFX06189.1 - 1.1e-20 73.4 0.0 1.5e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Transferase family DUF790 PF05626.6 EFX06190.1 - 0.011 14.3 1.5 0.02 13.4 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF790) Fib_alpha PF08702.5 EFX06190.1 - 0.023 14.7 8.6 0.065 13.3 6.0 1.9 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 EFX06190.1 - 0.028 14.2 2.6 0.067 12.9 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Prominin PF05478.6 EFX06190.1 - 0.082 10.4 12.0 0.13 9.7 8.3 1.3 1 0 0 1 1 1 0 Prominin DUF2935 PF11155.3 EFX06190.1 - 0.15 12.1 0.7 0.28 11.2 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) TBPIP PF07106.8 EFX06190.1 - 0.22 11.0 7.2 0.45 10.0 5.0 1.5 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF342 PF03961.8 EFX06190.1 - 0.25 9.7 3.9 0.41 9.0 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Tweety PF04906.8 EFX06190.1 - 0.28 9.5 12.9 2.4 6.4 7.7 2.1 2 0 0 2 2 2 0 Tweety CorA PF01544.13 EFX06190.1 - 0.3 10.0 1.7 0.55 9.2 1.2 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein GAS PF13851.1 EFX06190.1 - 0.33 10.1 14.5 0.057 12.6 6.1 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TMPIT PF07851.8 EFX06190.1 - 0.38 9.7 5.7 0.76 8.7 4.0 1.5 1 0 0 1 1 1 0 TMPIT-like protein Glyco_hydro_65N PF03636.10 EFX06190.1 - 1.5 8.0 11.7 2.5 7.3 7.8 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Peptidase_S64 PF08192.6 EFX06190.1 - 1.7 6.8 24.0 2.6 6.2 16.7 1.2 1 0 0 1 1 1 0 Peptidase family S64 V_ATPase_I PF01496.14 EFX06190.1 - 1.8 6.3 9.6 0.085 10.7 2.9 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Fmp27_WPPW PF10359.4 EFX06190.1 - 2.5 6.4 10.9 4.4 5.6 7.6 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF972 PF06156.8 EFX06190.1 - 4.3 7.7 11.7 0.33 11.3 4.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Atg14 PF10186.4 EFX06190.1 - 5.5 5.8 26.0 2.7 6.8 11.2 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Peptidase_C6 PF00851.13 EFX06190.1 - 5.9 5.4 9.7 8.6 4.8 6.7 1.2 1 0 0 1 1 1 0 Helper component proteinase UPF0118 PF01594.11 EFX06190.1 - 7.5 5.4 15.7 37 3.1 10.9 1.9 1 1 0 1 1 1 0 Domain of unknown function DUF20 DUF1387 PF07139.6 EFX06190.1 - 9.1 5.7 21.1 3.4 7.1 12.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1387) FSH1 PF03959.8 EFX06191.1 - 1.1e-47 162.2 0.0 1.7e-47 161.6 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 EFX06191.1 - 1.1e-05 25.2 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EFX06191.1 - 0.0045 16.9 0.0 0.44 10.3 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Frataxin_Cyay PF01491.11 EFX06192.1 - 5.5e-31 106.6 0.0 7.5e-31 106.1 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain ATG2_CAD PF13329.1 EFX06192.1 - 0.0061 16.1 0.0 0.0093 15.5 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif GIT_SHD PF08518.6 EFX06192.1 - 0.17 11.2 0.6 0.28 10.5 0.4 1.3 1 0 0 1 1 1 0 Spa2 homology domain (SHD) of GIT APH PF01636.18 EFX06193.1 - 4.1e-14 52.9 0.5 1.6e-13 50.9 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF2451 PF10474.4 EFX06193.1 - 0.035 13.8 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) Choline_kinase PF01633.15 EFX06193.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TPR_10 PF13374.1 EFX06195.1 - 1.1e-55 184.0 13.2 9.1e-10 38.1 0.0 8.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.1 EFX06195.1 - 3.1e-52 174.4 20.5 1.3e-17 63.4 0.0 6.7 3 2 5 9 9 8 6 Tetratricopeptide repeat TPR_7 PF13176.1 EFX06195.1 - 5.2e-20 69.6 10.6 0.00049 19.6 0.0 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_4 PF07721.9 EFX06195.1 - 5.8e-17 60.3 0.0 0.13 12.7 0.0 7.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 EFX06195.1 - 3.7e-16 57.9 0.3 0.14 11.8 0.0 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.12 EFX06195.1 - 3.3e-12 45.3 4.8 0.86 9.6 0.0 6.6 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_3 PF07720.7 EFX06195.1 - 5.2e-12 45.2 10.9 0.07 12.9 0.0 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 EFX06195.1 - 3.4e-11 42.4 1.0 3.1 8.2 0.0 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 EFX06195.1 - 2.8e-10 40.6 7.4 0.00018 22.0 0.0 5.7 4 2 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX06195.1 - 1.9e-08 34.5 1.1 0.24 11.7 0.0 6.2 5 1 2 7 7 7 2 Tetratricopeptide repeat AAA_22 PF13401.1 EFX06195.1 - 1.3e-07 31.8 0.0 6.2e-07 29.6 0.0 2.2 2 0 0 2 2 1 1 AAA domain TPR_11 PF13414.1 EFX06195.1 - 2.5e-07 30.2 0.2 0.0074 15.9 0.0 4.8 4 0 0 4 4 4 1 TPR repeat TPR_8 PF13181.1 EFX06195.1 - 1.8e-06 27.2 5.1 18 5.3 0.0 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat NB-ARC PF00931.17 EFX06195.1 - 7e-06 25.1 0.0 1.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_20 PF14561.1 EFX06195.1 - 2.6e-05 24.2 1.9 18 5.5 0.0 5.8 1 1 5 6 6 6 0 Tetratricopeptide repeat Apc3 PF12895.2 EFX06195.1 - 3.8e-05 23.7 6.1 0.064 13.3 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EFX06195.1 - 0.0068 16.9 12.6 57 4.7 0.0 7.5 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.1 EFX06195.1 - 0.18 12.3 15.0 26 5.5 0.0 6.8 7 0 0 7 7 6 0 Tetratricopeptide repeat CLN3 PF02487.12 EFX06196.1 - 1.2e-96 323.9 22.8 2.8e-52 177.8 1.1 3.0 1 1 0 2 2 2 2 CLN3 protein ADK PF00406.17 EFX06198.1 - 1.3e-58 197.1 0.0 1.7e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 EFX06198.1 - 1e-14 53.8 0.0 5.1e-14 51.6 0.0 2.0 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.1 EFX06198.1 - 2e-06 28.6 0.0 4.6e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EFX06198.1 - 4e-05 23.5 0.0 9.1e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFX06198.1 - 0.011 14.8 0.1 0.021 13.9 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 EFX06198.1 - 0.034 14.4 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF500 PF04366.7 EFX06199.1 - 1.9e-42 143.6 0.3 3.1e-42 142.9 0.2 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF500) Hid1 PF12722.2 EFX06199.1 - 0.16 9.6 0.7 0.21 9.1 0.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FimP PF09766.4 EFX06199.1 - 2.4 7.1 12.1 4.1 6.3 8.4 1.3 1 0 0 1 1 1 0 Fms-interacting protein Fungal_trans_2 PF11951.3 EFX06200.1 - 1.5e-14 53.4 0.2 1.9e-13 49.7 0.1 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06200.1 - 1.2e-08 34.7 11.0 2.1e-08 33.9 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.9 EFX06201.1 - 9.5 5.5 12.6 19 4.5 8.7 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Amidohydro_4 PF13147.1 EFX06202.1 - 3.8e-12 46.8 7.0 5.6e-09 36.4 4.1 4.3 3 2 1 4 4 4 2 Amidohydrolase Amidohydro_5 PF13594.1 EFX06202.1 - 9.6e-10 38.1 3.4 2.3e-09 36.9 0.3 2.8 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.15 EFX06202.1 - 6.3e-09 35.9 0.1 1e-05 25.3 0.0 2.7 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_3 PF07969.6 EFX06202.1 - 1.7e-07 30.8 0.4 0.00026 20.3 0.1 2.6 2 0 0 2 2 2 2 Amidohydrolase family TPR_12 PF13424.1 EFX06203.1 - 2.4e-33 113.9 18.0 2.5e-14 52.9 0.9 4.9 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 EFX06203.1 - 1.2e-31 107.6 11.6 7.1e-10 38.4 0.2 6.8 7 0 0 7 7 6 4 Tetratricopeptide repeat Ank_2 PF12796.2 EFX06203.1 - 9.4e-27 93.1 3.9 5.8e-14 52.1 0.9 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX06203.1 - 1.5e-23 81.3 12.1 1.4e-08 34.1 0.4 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 EFX06203.1 - 1.6e-18 66.3 6.3 1.5e-06 28.2 0.7 4.8 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX06203.1 - 2.5e-16 58.1 3.1 2e-05 24.3 0.1 4.9 5 0 0 5 5 4 3 Ankyrin repeat Ank_4 PF13637.1 EFX06203.1 - 1.9e-15 56.8 5.0 5.8e-05 23.4 0.2 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) TPR_11 PF13414.1 EFX06203.1 - 9.8e-09 34.7 1.2 7.7e-05 22.2 0.3 3.4 3 0 0 3 3 3 2 TPR repeat TPR_7 PF13176.1 EFX06203.1 - 1.4e-08 33.8 6.9 0.13 12.1 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFX06203.1 - 2.7e-07 29.9 6.2 0.14 12.1 0.2 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFX06203.1 - 4.1e-07 29.3 6.5 0.061 12.9 0.3 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 EFX06203.1 - 4.4e-05 23.7 8.1 0.053 13.8 0.2 4.2 4 1 1 5 5 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 EFX06203.1 - 0.00035 20.5 1.0 1.5 9.2 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.9 EFX06203.1 - 0.0062 16.8 2.5 5.3 7.7 0.1 3.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EFX06203.1 - 0.17 11.7 3.6 2.7 7.9 0.5 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 EFX06203.1 - 0.27 11.9 9.9 2.7 8.7 0.1 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 EFX06203.1 - 0.62 10.8 19.2 3.9 8.3 0.2 6.3 5 2 2 7 7 5 0 Tetratricopeptide repeat Ndc1_Nup PF09531.5 EFX06204.1 - 5.3e-130 434.6 0.3 6.1e-130 434.4 0.2 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup MFS_1 PF07690.11 EFX06205.1 - 8.3e-32 110.2 35.0 8.3e-32 110.2 24.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EFX06205.1 - 7.7e-06 24.3 3.0 7.7e-06 24.3 2.1 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF4381 PF14316.1 EFX06205.1 - 2.4 8.2 7.1 4.3 7.4 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) DUF663 PF04950.7 EFX06206.1 - 9.7e-98 326.7 0.0 1.4e-97 326.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EFX06206.1 - 3.5e-21 74.5 0.0 7.9e-21 73.4 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Ima1_N PF09779.4 EFX06207.1 - 3.7e-40 137.4 4.4 6.2e-40 136.7 3.0 1.4 1 0 0 1 1 1 1 Ima1 N-terminal domain DUF3311 PF11755.3 EFX06207.1 - 0.0049 16.3 0.5 0.0049 16.3 0.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3311) RNHCP PF12647.2 EFX06207.1 - 0.083 12.7 1.7 0.32 10.8 0.1 2.3 2 0 0 2 2 2 0 RNHCP domain DZR PF12773.2 EFX06207.1 - 0.25 11.1 4.9 1.3 8.8 0.3 2.5 2 0 0 2 2 2 0 Double zinc ribbon Gcd10p PF04189.8 EFX06208.1 - 1.2e-65 221.5 0.0 1.6e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Gcd10p family rRNA_proc-arch PF13234.1 EFX06209.1 - 1.1e-85 287.0 0.0 8.8e-85 284.1 0.0 2.3 1 1 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 EFX06209.1 - 2e-57 193.3 1.9 4.5e-57 192.2 1.3 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 EFX06209.1 - 6.2e-21 74.6 0.0 1.4e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX06209.1 - 1.3e-06 28.2 0.0 2.9e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX06209.1 - 0.0035 17.2 0.4 0.039 13.7 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit T2SE PF00437.15 EFX06209.1 - 0.039 12.8 0.0 0.11 11.3 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein EABR PF12180.3 EFX06209.1 - 0.087 12.1 1.1 1.9 7.9 0.0 2.4 2 0 0 2 2 2 0 TSG101 and ALIX binding domain of CEP55 AA_permease_2 PF13520.1 EFX06210.1 - 2.7e-57 194.2 56.1 3.4e-57 193.9 38.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX06210.1 - 6.4e-29 100.6 47.3 8.6e-29 100.2 32.8 1.1 1 0 0 1 1 1 1 Amino acid permease Aldedh PF00171.17 EFX06211.1 - 1.6e-187 623.4 0.1 1.8e-187 623.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EFX06211.1 - 0.00058 18.6 0.0 0.00088 18.1 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.6 EFX06211.1 - 0.095 11.9 0.0 1 8.5 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) Ank_2 PF12796.2 EFX06213.1 - 9.5e-114 372.0 30.0 4.5e-24 84.5 0.2 5.6 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 EFX06213.1 - 8.6e-78 252.5 19.7 1.6e-08 33.9 0.0 11.1 11 0 0 11 11 11 11 Ankyrin repeat Ank_3 PF13606.1 EFX06213.1 - 3.1e-61 197.1 6.7 9e-06 25.4 0.0 11.2 11 0 0 11 11 11 11 Ankyrin repeat Ank_4 PF13637.1 EFX06213.1 - 9.3e-56 185.2 4.7 1e-11 44.9 0.1 7.1 5 2 1 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX06213.1 - 2.2e-47 157.9 20.6 1.7e-07 31.2 0.1 10.7 2 2 9 11 11 11 11 Ankyrin repeats (many copies) DUF1843 PF08898.5 EFX06213.1 - 5.5e-05 23.1 10.4 1.8 8.6 0.4 5.6 5 1 0 5 5 5 3 Domain of unknown function (DUF1843) Plectin PF00681.15 EFX06213.1 - 0.00012 21.5 0.2 3.2 7.3 0.0 4.5 4 0 0 4 4 4 2 Plectin repeat Rbsn PF11464.3 EFX06213.1 - 0.00078 18.9 0.6 66 3.1 0.0 6.0 7 0 0 7 7 7 0 Rabenosyn Rab binding domain adh_short PF00106.20 EFX06215.1 - 1.2e-16 61.0 0.1 2.3e-16 60.1 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 EFX06215.1 - 0.008 15.6 0.2 0.052 12.9 0.1 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.5 EFX06215.1 - 0.0091 15.6 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 KR domain HSP70 PF00012.15 EFX06216.1 - 4.2e-58 196.7 21.5 1.4e-57 194.9 0.1 3.1 3 0 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.8 EFX06216.1 - 0.0013 17.4 0.2 0.0077 14.8 0.1 2.2 1 1 0 1 1 1 1 MreB/Mbl protein HHH_8 PF14716.1 EFX06216.1 - 0.026 14.6 1.7 0.8 9.9 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain FGGY_C PF02782.11 EFX06216.1 - 0.029 14.0 0.1 0.11 12.0 0.0 2.0 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain bZIP_1 PF00170.16 EFX06217.1 - 9.9e-11 41.4 10.6 2.5e-10 40.1 7.3 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EFX06217.1 - 0.0004 20.1 8.1 0.0004 20.1 5.6 2.5 2 0 0 2 2 2 1 Basic region leucine zipper DivIC PF04977.10 EFX06217.1 - 1.5 8.3 18.8 0.31 10.5 0.5 2.6 2 0 0 2 2 2 0 Septum formation initiator TraU PF06834.6 EFX06217.1 - 8.5 5.3 12.0 19 4.2 8.3 1.7 1 1 0 1 1 1 0 TraU protein tRNA_U5-meth_tr PF05958.6 EFX06218.1 - 5.4e-09 35.2 0.0 6.8e-08 31.5 0.0 2.4 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 EFX06218.1 - 1.7e-06 27.7 0.0 3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06218.1 - 2.6e-06 27.9 0.0 6.2e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX06218.1 - 1.6e-05 24.8 0.3 4.8e-05 23.3 0.2 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EFX06218.1 - 0.0032 16.6 0.1 0.0055 15.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 EFX06218.1 - 0.043 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 EFX06218.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Ras PF00071.17 EFX06219.1 - 1e-47 161.4 0.0 1.4e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX06219.1 - 7.6e-12 45.7 0.0 1.3e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX06219.1 - 1.9e-05 23.9 0.0 4.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family ThiF PF00899.16 EFX06220.1 - 1.5e-40 138.1 0.2 3.3e-40 137.0 0.2 1.6 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 EFX06220.1 - 4.1e-28 96.7 0.2 8.7e-28 95.6 0.1 1.6 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UAE_UbL PF14732.1 EFX06220.1 - 7.6e-22 77.2 3.9 1.4e-21 76.3 0.3 2.5 3 0 0 3 3 3 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.4 EFX06220.1 - 5.3e-20 70.5 0.6 5.3e-20 70.5 0.4 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 EFX06220.1 - 0.0015 18.6 0.1 0.0044 17.1 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 EFX06220.1 - 0.0045 17.2 0.4 0.013 15.7 0.0 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding FeoA PF04023.9 EFX06220.1 - 0.0081 16.1 0.1 0.063 13.2 0.0 2.3 2 0 0 2 2 2 1 FeoA domain Pyr_redox PF00070.22 EFX06220.1 - 0.037 14.4 0.1 0.19 12.1 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Snf7 PF03357.16 EFX06221.1 - 2.1e-42 144.4 3.1 2.5e-42 144.1 2.1 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.7 EFX06221.1 - 0.00031 20.9 4.3 0.03 14.5 1.3 2.9 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.1 EFX06221.1 - 0.0031 16.9 7.5 0.004 16.6 4.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4201) DUF848 PF05852.6 EFX06221.1 - 0.008 16.0 5.6 0.016 15.0 3.9 1.5 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) CENP-F_leu_zip PF10473.4 EFX06221.1 - 0.012 15.4 9.5 0.62 9.9 7.3 2.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NuA4 PF09340.5 EFX06221.1 - 0.014 14.9 1.1 0.026 14.1 0.8 1.5 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Reo_sigmaC PF04582.7 EFX06221.1 - 0.015 14.4 3.2 0.052 12.7 1.1 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 EFX06221.1 - 0.025 11.9 8.8 0.033 11.5 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Tht1 PF04163.7 EFX06221.1 - 0.026 12.9 1.4 0.032 12.6 1.0 1.0 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein APG6 PF04111.7 EFX06221.1 - 0.034 13.2 7.9 0.048 12.7 5.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 EFX06221.1 - 0.064 12.8 6.4 0.21 11.1 0.2 2.2 1 1 1 2 2 2 0 IncA protein AAA_13 PF13166.1 EFX06221.1 - 0.065 11.7 4.4 0.34 9.3 3.3 1.7 1 1 0 1 1 1 0 AAA domain BLOC1_2 PF10046.4 EFX06221.1 - 0.093 12.8 7.9 0.099 12.7 2.2 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.6 EFX06221.1 - 0.2 11.5 2.9 21 5.1 1.7 3.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.4 EFX06221.1 - 0.3 10.6 6.8 0.15 11.6 1.5 2.6 2 1 1 3 3 3 0 Predicted coiled-coil protein (DUF2205) DUF972 PF06156.8 EFX06221.1 - 0.32 11.3 7.6 2.8 8.3 4.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FlxA PF14282.1 EFX06221.1 - 0.42 10.5 8.2 0.14 12.0 3.1 1.9 1 1 1 2 2 2 0 FlxA-like protein DUF3562 PF12085.3 EFX06221.1 - 0.57 10.0 2.6 1.8 8.4 0.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3562) Mnd1 PF03962.10 EFX06221.1 - 0.6 9.7 10.2 2.3 7.8 7.1 1.9 1 1 0 1 1 1 0 Mnd1 family Atg14 PF10186.4 EFX06221.1 - 0.69 8.7 6.6 1 8.2 4.6 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 EFX06221.1 - 0.77 8.1 6.7 4.3 5.6 3.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF342) OmpH PF03938.9 EFX06221.1 - 0.78 9.6 12.0 2.9 7.8 8.3 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) COG2 PF06148.6 EFX06221.1 - 0.8 9.5 6.8 1.2 9.0 1.7 2.7 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Mod_r PF07200.8 EFX06221.1 - 0.99 9.3 10.8 2.6 7.9 7.2 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2730 PF10805.3 EFX06221.1 - 1.4 8.6 7.1 3.7 7.3 2.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Bud13 PF09736.4 EFX06221.1 - 1.4 9.1 6.1 2 8.6 4.2 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF4337 PF14235.1 EFX06221.1 - 1.6 8.5 7.2 0.33 10.7 1.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) NYD-SP28_assoc PF14775.1 EFX06221.1 - 1.7 8.4 7.1 13 5.6 1.9 2.7 1 1 1 2 2 2 0 Sperm tail C-terminal domain TMF_DNA_bd PF12329.3 EFX06221.1 - 3.9 7.3 12.3 0.71 9.7 1.4 3.3 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding p450 PF00067.17 EFX06222.1 - 1.8e-33 115.7 0.0 1.4e-31 109.5 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.11 EFX06223.1 - 2.4e-37 128.4 29.2 2.4e-37 128.4 20.3 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.11 EFX06224.1 - 3.1e-16 59.0 27.7 5.9e-16 58.1 19.2 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EFX06224.1 - 7e-10 38.6 8.1 7e-10 38.6 5.6 2.5 3 1 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.19 EFX06224.1 - 0.0037 15.8 13.2 0.0037 15.8 9.2 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter Imm38 PF15599.1 EFX06224.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 38 PUCC PF03209.10 EFX06224.1 - 0.13 11.0 13.8 0.025 13.3 4.5 2.8 3 0 0 3 3 3 0 PUCC protein EutQ PF06249.7 EFX06225.1 - 4.5e-11 42.5 0.0 5.4e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.7 EFX06225.1 - 2.2e-10 39.7 0.0 3.2e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.6 EFX06225.1 - 1.2e-05 24.6 0.0 1.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.2 EFX06225.1 - 0.0036 16.9 0.0 0.0045 16.6 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.17 EFX06225.1 - 0.03 13.7 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Cupin AraC_binding PF02311.14 EFX06225.1 - 0.055 13.1 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain ARD PF03079.9 EFX06225.1 - 0.086 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 ARD/ARD' family adh_short_C2 PF13561.1 EFX06226.1 - 2.7e-33 115.7 1.2 3.1e-33 115.5 0.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EFX06226.1 - 9.2e-28 97.2 2.3 1.4e-27 96.6 1.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EFX06226.1 - 6.1e-10 39.0 0.4 9.1e-10 38.4 0.3 1.2 1 0 0 1 1 1 1 KR domain Dak1_2 PF13684.1 EFX06226.1 - 0.027 13.4 0.1 0.044 12.7 0.0 1.3 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Peptidase_C10 PF01640.12 EFX06226.1 - 0.072 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase C10 family R3H PF01424.17 EFX06227.1 - 1.2e-10 40.9 0.1 2.8e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 R3H domain RRM_6 PF14259.1 EFX06227.1 - 9.6e-06 25.4 0.1 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX06227.1 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EFX06227.1 - 0.0034 16.9 0.1 0.0094 15.5 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CtaG_Cox11 PF04442.9 EFX06228.1 - 2.6e-55 186.4 0.0 5.2e-55 185.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 NAD_binding_8 PF13450.1 EFX06228.1 - 1.4e-13 50.5 0.1 4e-13 49.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EFX06228.1 - 1.8e-12 47.0 1.1 1e-10 41.2 0.8 2.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.1 EFX06228.1 - 2.4e-05 24.5 0.0 0.0047 17.0 0.0 3.0 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX06228.1 - 3.5e-05 22.8 0.1 0.00041 19.3 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFX06228.1 - 0.00026 20.7 0.0 0.66 9.7 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox PF00070.22 EFX06228.1 - 0.016 15.6 0.0 0.064 13.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX06228.1 - 0.043 12.2 0.0 0.85 8.0 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.9 EFX06228.1 - 0.078 12.8 0.0 0.25 11.1 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF607 PF04678.8 EFX06230.1 - 2.8e-36 125.1 0.0 5.4e-36 124.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF607 Acetyltransf_8 PF13523.1 EFX06230.1 - 3.7e-31 108.0 0.1 6.7e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Spt20 PF12090.3 EFX06232.1 - 1.7e-42 144.8 0.0 1.7e-42 144.8 0.0 2.6 2 1 0 2 2 2 1 Spt20 family Fungal_trans PF04082.13 EFX06233.1 - 5.7e-10 38.4 0.1 1e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06233.1 - 8.8e-05 22.3 17.7 0.00018 21.3 12.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lectin_leg-like PF03388.8 EFX06233.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Legume-like lectin family PNK3P PF08645.6 EFX06234.1 - 1.9e-49 167.1 0.0 7.1e-49 165.2 0.0 2.0 1 1 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 EFX06234.1 - 4.5e-27 94.6 0.0 2.2e-26 92.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain GHMP_kinases_N PF00288.21 EFX06234.1 - 1.1e-09 38.2 2.2 2.3e-09 37.2 0.5 2.4 2 0 0 2 2 2 1 GHMP kinases N terminal domain Zeta_toxin PF06414.7 EFX06234.1 - 0.0038 16.3 0.0 0.008 15.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF3248 PF11609.3 EFX06234.1 - 0.097 12.3 0.2 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3248) PTH2 PF01981.11 EFX06235.1 - 1.6e-37 127.7 0.1 2.1e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 S10_plectin PF03501.10 EFX06236.1 - 2e-37 126.8 0.1 2.4e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Pro-kuma_activ PF09286.6 EFX06237.1 - 4e-45 153.3 0.0 1e-44 152.0 0.0 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain BTB_2 PF02214.17 EFX06241.1 - 7.1e-05 22.9 0.0 0.0076 16.4 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain RabGAP-TBC PF00566.13 EFX06242.1 - 2.5e-46 157.8 0.1 3.1e-45 154.2 0.0 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ADIP PF11559.3 EFX06242.1 - 0.41 10.5 20.6 0.28 11.0 4.6 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding PilJ PF13675.1 EFX06242.1 - 0.67 10.2 7.3 1.1 9.6 0.6 2.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Microtub_assoc PF07989.6 EFX06242.1 - 1 9.2 12.7 1.5 8.6 3.0 2.8 2 0 0 2 2 2 0 Microtubule associated DUF3505 PF12013.3 EFX06244.1 - 0.3 11.3 4.3 0.61 10.3 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) zf-FPG_IleRS PF06827.9 EFX06244.1 - 0.44 10.2 3.8 14 5.4 0.0 2.8 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS Histone PF00125.19 EFX06245.1 - 2.1e-22 78.9 0.1 2.8e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EFX06245.1 - 4.5e-05 23.4 0.0 6.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Daxx PF03344.10 EFX06246.1 - 3.8 5.8 45.9 0.013 13.9 19.3 2.7 3 0 0 3 3 3 0 Daxx Family Methyltransf_11 PF08241.7 EFX06248.1 - 6.2e-25 87.5 0.0 1e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX06248.1 - 1.6e-22 79.6 0.0 2e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06248.1 - 6.1e-19 68.6 0.0 1.1e-18 67.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EFX06248.1 - 7.4e-19 67.9 0.0 1.1e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX06248.1 - 3.7e-16 59.4 0.0 6e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EFX06248.1 - 1e-14 54.5 0.0 1.5e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX06248.1 - 8.7e-14 51.1 0.0 1.6e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EFX06248.1 - 2.7e-13 49.9 0.7 4.8e-13 49.1 0.5 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX06248.1 - 5.4e-10 38.8 0.0 8.1e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 EFX06248.1 - 1e-08 34.9 0.0 1.5e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.6 EFX06248.1 - 4.3e-07 29.5 0.0 1.4e-06 27.8 0.0 1.7 1 1 1 2 2 2 1 Nodulation protein S (NodS) Methyltransf_4 PF02390.12 EFX06248.1 - 2.1e-06 26.9 0.0 9.9e-06 24.7 0.0 1.9 1 1 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 EFX06248.1 - 2.4e-05 23.5 0.0 3.4e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DUF938 PF06080.7 EFX06248.1 - 0.00012 21.6 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_32 PF13679.1 EFX06248.1 - 0.0016 18.1 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 EFX06248.1 - 0.0016 16.8 0.0 0.0028 16.0 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase FtsJ PF01728.14 EFX06248.1 - 0.0019 18.2 0.0 0.0031 17.5 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_24 PF13578.1 EFX06248.1 - 0.0042 17.8 0.0 0.026 15.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.15 EFX06248.1 - 0.0065 15.5 0.0 0.0091 15.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CheR PF01739.13 EFX06248.1 - 0.0075 15.5 0.0 0.14 11.4 0.0 2.1 1 1 0 2 2 2 1 CheR methyltransferase, SAM binding domain FmrO PF07091.6 EFX06248.1 - 0.016 14.2 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) MetW PF07021.7 EFX06248.1 - 0.017 14.5 0.0 0.041 13.2 0.0 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Nol1_Nop2_Fmu PF01189.12 EFX06248.1 - 0.05 12.9 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 NOL1/NOP2/sun family 3HCDH_N PF02737.13 EFX06248.1 - 0.082 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_8 PF05148.10 EFX06248.1 - 0.09 12.3 0.0 0.55 9.8 0.0 1.9 1 1 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_9 PF08003.6 EFX06248.1 - 0.092 11.4 0.0 0.19 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PAP2 PF01569.16 EFX06249.1 - 6.1e-18 64.7 2.8 6.1e-18 64.7 1.9 1.9 2 0 0 2 2 2 1 PAP2 superfamily WD40 PF00400.27 EFX06250.1 - 1.2e-39 132.8 8.1 7.3e-07 28.8 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EFX06250.1 - 5.4e-12 45.2 2.7 1.2e-11 44.1 1.9 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX06250.1 - 1.3e-06 27.8 0.5 3.8e-06 26.4 0.3 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EFX06250.1 - 0.00013 20.3 0.4 0.039 12.0 0.1 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 HbrB PF08539.6 EFX06252.1 - 5.5e-51 172.5 0.0 1.3e-50 171.3 0.0 1.7 1 0 0 1 1 1 1 HbrB-like Vps39_2 PF10367.4 EFX06252.1 - 7e-27 93.7 3.5 5.4e-26 90.9 0.0 2.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.4 EFX06252.1 - 8.6e-20 70.7 0.0 8.6e-20 70.7 0.0 3.6 3 1 1 4 4 4 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.17 EFX06252.1 - 2.6e-07 30.3 0.0 7.3e-07 28.8 0.0 1.8 1 1 0 1 1 1 1 CNH domain DUF3893 PF13032.1 EFX06252.1 - 0.0078 16.3 0.0 0.0078 16.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3893) FHIPEP PF00771.15 EFX06252.1 - 9.8 4.3 12.1 11 4.2 7.1 2.0 2 0 0 2 2 2 0 FHIPEP family Glycos_transf_1 PF00534.15 EFX06253.1 - 5.4e-28 97.5 0.0 2.6e-27 95.3 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFX06253.1 - 7.1e-07 29.4 0.4 4.8e-05 23.5 0.2 2.8 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EFX06253.1 - 3.8e-06 26.7 0.2 8.3e-05 22.3 0.1 2.2 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 EFX06253.1 - 2.8e-05 24.2 9.6 2.8e-05 24.2 6.7 2.8 2 2 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 EFX06253.1 - 0.00084 19.5 0.1 0.0033 17.6 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 DBR1 PF05011.8 EFX06254.1 - 5.3e-45 152.8 0.0 8e-45 152.2 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 EFX06254.1 - 2.1e-05 24.0 1.0 5.2e-05 22.7 0.7 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase MatE PF01554.13 EFX06256.1 - 1.6e-44 151.4 33.6 7.4e-28 97.2 6.6 2.4 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.1 EFX06256.1 - 0.00016 21.4 3.9 0.00016 21.4 2.7 4.2 2 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Como_SCP PF02248.11 EFX06256.1 - 0.25 10.7 1.4 0.24 10.7 0.1 1.5 2 0 0 2 2 2 0 Small coat protein DNA_pol_delta_4 PF04081.8 EFX06257.1 - 4.8e-29 101.1 0.9 9.8e-29 100.1 0.6 1.6 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 CPSF100_C PF13299.1 EFX06257.1 - 0.033 14.3 3.2 0.044 13.9 1.6 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.7 EFX06257.1 - 1 9.1 6.5 1.3 8.8 4.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OB_NTP_bind PF07717.11 EFX06258.1 - 9e-24 83.5 0.0 1.8e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EFX06258.1 - 6.3e-23 80.7 0.1 1.3e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EFX06258.1 - 1.9e-10 40.4 0.0 5.8e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EFX06258.1 - 9.8e-07 28.9 0.1 3.9e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain DEAD PF00270.24 EFX06258.1 - 7.7e-06 25.4 0.1 4.6e-05 22.9 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase SRP54 PF00448.17 EFX06258.1 - 0.0049 16.3 0.0 0.012 15.0 0.0 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain T2SE PF00437.15 EFX06258.1 - 0.007 15.2 0.0 0.013 14.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.1 EFX06258.1 - 0.031 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 EFX06258.1 - 0.041 13.7 0.1 4.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_23 PF13476.1 EFX06258.1 - 0.044 14.1 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain GDE_N PF12439.3 EFX06258.1 - 0.073 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal Rad21_Rec8 PF04824.11 EFX06258.1 - 0.31 10.2 1.9 8.1 5.7 0.0 2.6 2 0 0 2 2 2 0 Conserved region of Rad21 / Rec8 like protein Tubulin PF00091.20 EFX06260.1 - 3.2e-70 236.3 0.0 4.4e-70 235.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EFX06260.1 - 6.2e-49 165.2 0.1 1.1e-48 164.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 EFX06260.1 - 0.0026 17.2 0.0 0.0064 15.9 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain ATG22 PF11700.3 EFX06261.1 - 4.3e-127 424.4 31.6 4.9e-127 424.3 21.9 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 EFX06261.1 - 8.1e-09 34.6 33.4 0.00047 18.9 5.8 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Pkinase PF00069.20 EFX06262.1 - 1.1e-50 172.2 0.0 1.4e-50 171.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX06262.1 - 1.2e-37 129.4 0.0 1.6e-37 128.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EFX06262.1 - 0.00088 18.3 0.0 0.0045 16.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EFX06262.1 - 0.072 12.1 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aldo_ket_red PF00248.16 EFX06263.1 - 6.6e-76 254.8 0.0 7.5e-76 254.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CENP-X PF09415.5 EFX06264.1 - 1.5e-22 79.1 0.0 3.2e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 CENP-S associating Centromere protein X Pox_Ag35 PF03286.9 EFX06264.1 - 0.21 11.0 4.1 0.31 10.5 2.8 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FYDLN_acid PF09538.5 EFX06264.1 - 0.52 10.9 10.4 0.8 10.3 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Ald_Xan_dh_C2 PF02738.13 EFX06265.1 - 8.4e-182 605.2 0.1 1.2e-181 604.7 0.1 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.16 EFX06265.1 - 1.1e-44 151.8 0.0 2.1e-44 150.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.12 EFX06265.1 - 9.1e-34 115.4 3.2 2.6e-32 110.8 0.1 2.8 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.15 EFX06265.1 - 5e-29 100.0 0.1 1.4e-28 98.5 0.0 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.17 EFX06265.1 - 5.8e-28 97.1 1.0 1.8e-27 95.6 0.3 2.1 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.22 EFX06265.1 - 1.4e-07 31.1 0.1 1.4e-07 31.1 0.1 3.0 2 1 1 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain DUF1741 PF08427.5 EFX06266.1 - 8.1e-64 215.3 0.4 1.5e-54 184.9 0.0 3.1 2 1 1 3 3 3 3 Domain of unknown function (DUF1741) Thiolase_C PF02803.13 EFX06267.1 - 1.7e-10 40.3 0.2 1.5e-09 37.3 0.1 2.5 1 1 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 EFX06267.1 - 4.5e-05 22.5 2.0 0.00012 21.2 0.0 2.5 3 1 0 3 3 3 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 EFX06267.1 - 5.4e-05 22.7 0.1 0.0043 16.6 0.0 2.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.17 EFX06267.1 - 0.00036 20.3 1.6 0.013 15.3 0.0 3.3 4 0 0 4 4 4 1 Beta-ketoacyl synthase, C-terminal domain SNAP PF14938.1 EFX06269.1 - 4.6e-112 373.7 17.5 5.1e-112 373.6 12.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 EFX06269.1 - 5.3e-09 35.8 15.2 0.0011 18.8 1.0 4.5 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 EFX06269.1 - 7.4e-08 31.7 21.7 0.33 10.9 0.3 6.9 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.1 EFX06269.1 - 5.6e-07 29.1 19.0 0.0034 16.9 0.4 3.9 1 1 2 3 3 3 3 TPR repeat TPR_6 PF13174.1 EFX06269.1 - 1.2e-06 28.5 9.9 0.11 12.9 0.0 5.8 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX06269.1 - 3e-05 24.2 15.9 2.6 8.9 0.1 6.4 2 1 4 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 EFX06269.1 - 0.00018 20.9 15.5 3.7 7.3 0.2 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 EFX06269.1 - 0.00068 20.2 21.1 0.023 15.3 1.2 4.4 1 1 4 5 5 5 3 Tetratricopeptide repeat RPN7 PF10602.4 EFX06269.1 - 0.0013 18.1 3.0 0.67 9.3 0.1 3.5 1 1 1 3 3 3 2 26S proteasome subunit RPN7 TPR_8 PF13181.1 EFX06269.1 - 0.0013 18.3 13.9 0.51 10.2 0.1 5.9 5 1 1 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 EFX06269.1 - 0.0033 17.5 2.1 0.0033 17.5 1.5 3.2 2 2 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EFX06269.1 - 0.0051 17.1 0.2 0.0051 17.1 0.1 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 EFX06269.1 - 0.012 15.3 8.4 2.8 7.9 0.1 4.9 4 1 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.12 EFX06269.1 - 0.066 13.5 2.2 0.78 10.0 0.2 2.7 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TRAPPC-Trs85 PF12739.2 EFX06269.1 - 0.07 11.7 4.7 0.3 9.6 3.2 2.2 1 1 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Ctr PF04145.10 EFX06270.1 - 8.8e-28 97.1 6.7 1.7e-27 96.2 4.6 1.4 1 1 0 1 1 1 1 Ctr copper transporter family DUF2156 PF09924.4 EFX06270.1 - 0.1 11.3 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2156) Glycos_transf_1 PF00534.15 EFX06272.1 - 1.9e-22 79.5 0.0 2.8e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFX06272.1 - 1e-09 38.6 0.1 7.3e-08 32.6 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Phage_P2_GpE PF06528.7 EFX06272.1 - 0.0047 16.3 1.6 0.12 11.8 0.1 2.8 2 0 0 2 2 2 1 Phage P2 GpE Glyco_transf_4 PF13439.1 EFX06272.1 - 0.022 14.4 0.0 0.06 13.0 0.0 1.8 1 0 0 1 1 1 0 Glycosyltransferase Family 4 SART-1 PF03343.8 EFX06274.1 - 6e-126 421.2 38.2 7.1e-126 421.0 26.5 1.0 1 0 0 1 1 1 1 SART-1 family Fungal_trans PF04082.13 EFX06275.1 - 4.5e-18 65.0 0.0 8.6e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3632 PF12311.3 EFX06276.1 - 2.7e-38 131.6 0.8 3.8e-38 131.1 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) FUSC-like PF12805.2 EFX06279.1 - 0.21 10.4 2.3 0.79 8.5 0.5 2.1 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS Fungal_trans PF04082.13 EFX06280.1 - 2.5e-31 108.4 0.4 5.1e-31 107.4 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06280.1 - 2.7e-08 33.5 13.4 2.7e-08 33.5 9.3 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2046 PF09755.4 EFX06280.1 - 0.046 12.5 0.4 0.1 11.5 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Herpes_BLRF2 PF05812.7 EFX06280.1 - 0.2 11.4 2.9 0.35 10.6 0.0 2.5 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein AIP3 PF03915.8 EFX06281.1 - 7.9e-145 482.9 12.8 2.5e-105 352.8 5.1 2.2 1 1 1 2 2 2 2 Actin interacting protein 3 DUF1664 PF07889.7 EFX06281.1 - 7.2e-05 22.5 6.5 0.13 12.0 1.3 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) AAA_13 PF13166.1 EFX06281.1 - 0.0067 14.9 3.2 0.013 14.0 2.3 1.4 1 0 0 1 1 1 1 AAA domain FliL PF03748.9 EFX06281.1 - 0.033 14.1 0.2 0.14 12.2 0.1 2.1 1 0 0 1 1 1 0 Flagellar basal body-associated protein FliL Baculo_PEP_C PF04513.7 EFX06281.1 - 0.081 12.7 9.0 0.59 9.9 0.7 3.6 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.7 EFX06281.1 - 0.15 12.3 7.1 0.28 11.4 0.2 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Prominin PF05478.6 EFX06281.1 - 0.16 9.4 4.0 0.28 8.6 2.8 1.3 1 0 0 1 1 1 0 Prominin Occludin_ELL PF07303.8 EFX06281.1 - 0.34 11.6 3.8 12 6.6 0.5 3.0 2 1 0 2 2 2 0 Occludin homology domain WXG100 PF06013.7 EFX06281.1 - 0.44 10.5 7.7 0.46 10.5 1.6 3.7 4 0 0 4 4 4 0 Proteins of 100 residues with WXG TPR_MLP1_2 PF07926.7 EFX06281.1 - 0.54 10.0 12.6 0.082 12.6 1.5 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Syntaxin_2 PF14523.1 EFX06281.1 - 0.76 9.8 9.7 3.1 7.8 0.0 3.8 4 0 0 4 4 3 0 Syntaxin-like protein CorA PF01544.13 EFX06281.1 - 1.1 8.2 9.8 0.88 8.5 0.5 2.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF972 PF06156.8 EFX06281.1 - 1.5 9.1 6.4 2.9 8.3 0.7 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Fib_alpha PF08702.5 EFX06281.1 - 2.4 8.2 6.4 3.1 7.8 0.8 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family FH2 PF02181.18 EFX06281.1 - 3.3 6.5 7.9 4.9 5.9 0.7 2.4 2 0 0 2 2 2 0 Formin Homology 2 Domain TMPIT PF07851.8 EFX06281.1 - 3.4 6.6 3.1 12 4.8 0.3 2.4 2 0 0 2 2 2 0 TMPIT-like protein Syntaxin PF00804.20 EFX06281.1 - 3.9 7.6 8.9 13 6.0 0.1 3.7 3 0 0 3 3 3 0 Syntaxin DEAD PF00270.24 EFX06282.1 - 3.9e-32 111.0 0.0 5.6e-16 58.4 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX06282.1 - 7.5e-20 70.5 0.0 1.6e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 EFX06282.1 - 2e-17 62.4 0.0 4e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 EFX06282.1 - 0.0018 18.1 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Collagen PF01391.13 EFX06283.1 - 3.5e-11 42.4 59.3 7.2e-08 31.8 18.6 2.6 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) Rad52_Rad22 PF04098.10 EFX06283.1 - 0.18 11.5 2.2 0.23 11.1 1.5 1.1 1 0 0 1 1 1 0 Rad52/22 family double-strand break repair protein ATG27 PF09451.5 EFX06284.1 - 3.8e-63 213.2 0.0 1.1e-62 211.7 0.0 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.13 EFX06284.1 - 1.5e-05 24.7 0.0 0.00065 19.4 0.0 2.3 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat Aminotran_3 PF00202.16 EFX06286.1 - 6.6e-95 317.8 0.5 8.2e-95 317.5 0.3 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Telomere_Sde2 PF13019.1 EFX06287.1 - 1.7e-61 206.6 0.1 2.5e-61 206.1 0.1 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Orthopox_F7 PF05813.7 EFX06287.1 - 0.013 15.4 0.8 0.038 13.8 0.1 2.0 2 0 0 2 2 2 0 Orthopoxvirus F7 protein DUF1675 PF07897.6 EFX06287.1 - 1.9 8.2 9.9 2.7 7.8 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Sugar_tr PF00083.19 EFX06288.1 - 5.4e-43 147.2 11.5 8.7e-29 100.3 0.1 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EFX06288.1 - 6.6e-17 61.2 21.2 8.2e-09 34.6 0.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 EFX06288.1 - 0.041 13.6 0.2 0.35 10.7 0.0 2.5 3 0 0 3 3 3 0 MFS_1 like family ECF-ribofla_trS PF07155.7 EFX06288.1 - 1.3 8.7 23.3 2.3 7.9 4.9 3.2 2 1 1 3 3 3 0 ECF-type riboflavin transporter, S component PgaD PF13994.1 EFX06290.1 - 0.074 12.5 1.9 0.14 11.6 0.0 2.4 2 0 0 2 2 2 0 PgaD-like protein Baculo_PEP_C PF04513.7 EFX06290.1 - 0.12 12.1 13.5 0.15 11.8 2.0 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADH_N PF08240.7 EFX06291.1 - 1.7e-29 101.7 0.4 2.8e-29 101.0 0.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX06291.1 - 2.9e-16 59.2 2.1 4.7e-16 58.5 1.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EFX06291.1 - 1.4e-09 38.9 0.4 2.9e-09 37.8 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Shikimate_DH PF01488.15 EFX06291.1 - 0.026 14.6 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase L51_S25_CI-B8 PF05047.11 EFX06292.1 - 3.9e-20 71.3 0.0 6.6e-20 70.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ADH_N PF08240.7 EFX06294.1 - 4.2e-22 77.9 2.1 4.2e-22 77.9 1.5 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.1 EFX06294.1 - 9.1e-11 41.2 1.8 9.1e-11 41.2 1.2 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.21 EFX06294.1 - 0.0015 18.0 0.4 0.049 13.1 0.0 3.1 3 1 0 3 3 3 1 Zinc-binding dehydrogenase Zn_clus PF00172.13 EFX06296.1 - 0.0011 18.8 6.1 0.0027 17.5 4.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-met PF12874.2 EFX06296.1 - 0.0029 17.7 0.2 0.0081 16.3 0.1 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EFX06296.1 - 0.0042 17.3 5.8 0.022 15.0 4.0 2.3 1 0 0 1 1 1 1 C2H2-type zinc finger BTV_NS2 PF04514.7 EFX06296.1 - 0.11 11.4 0.1 0.16 10.8 0.1 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 zf-C2H2 PF00096.21 EFX06296.1 - 0.14 12.5 5.7 0.46 10.9 3.9 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type Zn_ribbon_recom PF13408.1 EFX06296.1 - 5.7 7.2 9.0 18 5.6 6.2 1.9 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Hexapep PF00132.19 EFX06297.1 - 3.1e-08 32.7 1.9 0.0017 17.8 0.0 2.7 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EFX06297.1 - 3.7e-05 23.8 0.0 3.7e-05 23.8 0.0 2.3 2 1 0 2 2 2 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 EFX06297.1 - 0.0002 20.7 0.0 0.00041 19.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.1 EFX06297.1 - 0.1 12.1 7.0 7.5 6.2 0.1 3.4 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Gp_dh_C PF02800.15 EFX06298.1 - 2.5e-63 212.2 0.5 4.3e-49 165.9 0.1 2.2 1 1 1 2 2 2 2 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 EFX06298.1 - 2.6e-59 199.5 0.2 4.1e-59 198.8 0.2 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Vel1p PF10339.4 EFX06298.1 - 0.086 11.9 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Yeast-specific zinc responsive Peptidase_M20 PF01546.23 EFX06299.1 - 4.1e-25 88.3 0.0 1.2e-24 86.8 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EFX06299.1 - 5.4e-11 42.2 0.6 2e-10 40.4 0.4 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain KxDL PF10241.4 EFX06300.1 - 1.7e-25 88.7 3.5 2.2e-25 88.3 2.4 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein Mating_C PF12737.2 EFX06300.1 - 0.0039 16.1 2.1 0.97 8.2 0.0 2.2 2 0 0 2 2 2 2 C-terminal domain of homeodomain 1 DUF2125 PF09898.4 EFX06300.1 - 0.012 14.9 0.3 0.71 9.1 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2125) FRG1 PF06229.7 EFX06300.1 - 0.073 12.5 1.5 0.096 12.1 1.0 1.2 1 0 0 1 1 1 0 FRG1-like family RasGEF PF00617.14 EFX06303.1 - 2e-54 184.2 0.0 7e-54 182.4 0.0 1.9 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 EFX06303.1 - 7.9e-18 64.4 0.0 3.3e-17 62.4 0.0 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_9 PF14604.1 EFX06303.1 - 3.8e-06 26.3 0.0 7.8e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EFX06303.1 - 3.5e-05 23.0 0.0 8.3e-05 21.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain LdpA_C PF12617.3 EFX06303.1 - 0.036 13.3 0.7 0.082 12.1 0.5 1.6 1 0 0 1 1 1 0 Iron-Sulfur binding protein C terminal Gelsolin PF00626.17 EFX06304.1 - 1.1e-28 98.7 0.0 3.6e-12 45.7 0.0 3.4 3 0 0 3 3 3 3 Gelsolin repeat ADH_zinc_N PF00107.21 EFX06304.1 - 2.7e-13 49.5 0.6 5.2e-13 48.6 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EFX06304.1 - 3.1e-11 42.9 0.0 7.4e-11 41.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Eno-Rase_NADH_b PF12242.3 EFX06304.1 - 0.02 14.6 0.6 0.049 13.4 0.4 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N_2 PF13602.1 EFX06304.1 - 0.023 15.5 1.7 0.086 13.7 0.1 2.8 2 1 1 3 3 3 0 Zinc-binding dehydrogenase TRF PF08558.5 EFX06305.1 - 2.9e-30 105.3 0.3 7.4e-27 94.2 0.2 2.4 2 0 0 2 2 2 2 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 EFX06305.1 - 5.9e-06 26.2 0.0 1.4e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX06305.1 - 0.037 14.1 0.0 0.099 12.7 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain HNH_2 PF13391.1 EFX06306.1 - 9.2e-07 28.5 0.1 1.9e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 HNH endonuclease PH_10 PF15411.1 EFX06307.1 - 2.7e-45 153.2 0.1 5.4e-45 152.3 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.15 EFX06307.1 - 7.2e-33 113.9 0.6 1.3e-32 113.1 0.4 1.4 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.6 EFX06307.1 - 2.6e-32 110.7 0.0 5.2e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.19 EFX06307.1 - 2.9e-08 33.2 0.1 6.4e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 PB1 domain PH PF00169.24 EFX06307.1 - 0.066 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 PH domain BRO1 PF03097.13 EFX06308.1 - 5.1e-107 357.8 0.1 7.7e-107 357.2 0.1 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EFX06308.1 - 3.9e-72 242.7 2.1 5.5e-72 242.2 0.4 2.1 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV PAT1 PF09770.4 EFX06308.1 - 0.018 13.3 24.4 0.21 9.8 16.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Steroid_dh PF02544.11 EFX06309.1 - 4.1e-19 68.8 0.1 1.5e-11 44.3 0.0 2.3 2 0 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 EFX06309.1 - 8.8e-05 21.9 2.3 0.00022 20.6 1.2 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) MENTAL PF10457.4 EFX06309.1 - 0.12 11.9 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Cholesterol-capturing domain Zn_clus PF00172.13 EFX06310.1 - 2.4e-09 36.9 6.9 3.8e-09 36.3 4.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EFX06310.1 - 1.7e-08 33.5 0.4 0.00055 18.6 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain SNARE PF05739.14 EFX06312.1 - 4.4e-20 71.1 4.2 4.4e-20 71.1 2.9 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.1 EFX06312.1 - 7.2e-11 42.0 12.2 2.5e-06 27.4 1.1 3.7 2 2 1 3 3 3 2 Syntaxin-like protein Synaptobrevin PF00957.16 EFX06312.1 - 0.014 14.9 0.4 0.038 13.5 0.3 1.7 1 0 0 1 1 1 0 Synaptobrevin DinB_2 PF12867.2 EFX06312.1 - 0.049 13.9 0.1 0.081 13.2 0.0 1.3 1 0 0 1 1 1 0 DinB superfamily DUF3708 PF12501.3 EFX06312.1 - 0.37 10.6 6.7 0.16 11.7 1.7 2.1 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter DUF3450 PF11932.3 EFX06312.1 - 1.9 7.6 12.1 0.27 10.4 5.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Fzo_mitofusin PF04799.8 EFX06312.1 - 3.8 6.8 7.3 5.1 6.4 0.0 2.4 2 1 0 2 2 2 0 fzo-like conserved region ABC_tran PF00005.22 EFX06313.1 - 2.8e-28 98.9 0.0 1.3e-18 67.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EFX06313.1 - 1.1e-10 42.0 0.0 0.00032 20.7 0.0 3.2 3 0 0 3 3 3 3 AAA domain ABC_membrane PF00664.18 EFX06313.1 - 1.6e-10 40.8 23.9 3.5e-08 33.2 6.9 4.0 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 EFX06313.1 - 1.6e-06 27.5 0.1 0.17 11.1 0.0 3.0 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 EFX06313.1 - 0.0008 18.8 0.2 0.015 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EFX06313.1 - 0.0015 18.0 0.2 0.0045 16.4 0.1 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family SbcCD_C PF13558.1 EFX06313.1 - 0.0031 17.3 2.8 0.37 10.7 0.0 3.2 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 EFX06313.1 - 0.0035 17.3 0.6 0.01 15.8 0.4 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX06313.1 - 0.0038 17.3 0.2 0.03 14.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.12 EFX06313.1 - 0.044 13.5 0.2 0.076 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 MobB PF03205.9 EFX06313.1 - 0.044 13.4 0.0 0.12 12.0 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 EFX06313.1 - 0.049 14.1 0.1 0.15 12.5 0.1 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 EFX06313.1 - 0.051 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.24 EFX06313.1 - 0.059 12.8 0.2 0.87 9.0 0.1 2.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF258 PF03193.11 EFX06313.1 - 0.069 12.3 0.1 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFX06313.1 - 0.08 12.3 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain DUF1240 PF06836.7 EFX06313.1 - 0.92 9.7 4.9 0.4 10.9 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) DUF3901 PF13040.1 EFX06314.1 - 0.45 9.8 2.9 0.99 8.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3901) DUF423 PF04241.10 EFX06315.1 - 3.5e-24 84.5 3.7 7.9e-24 83.4 2.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF423) Trep_Strep PF09605.5 EFX06315.1 - 0.3 10.7 3.2 0.11 12.2 0.2 1.6 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) YiaAB PF05360.9 EFX06315.1 - 0.85 9.2 5.2 4.9 6.7 0.0 3.1 3 0 0 3 3 3 0 yiaA/B two helix domain DUF1469 PF07332.6 EFX06315.1 - 1.9 8.2 4.9 13 5.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF3325 PF11804.3 EFX06315.1 - 1.9 8.4 7.8 5.2 7.0 5.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3325) Cyt-b5 PF00173.23 EFX06317.1 - 2.3e-11 43.3 0.1 3.9e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Erv26 PF04148.8 EFX06317.1 - 0.019 14.3 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 Abhydrolase_3 PF07859.8 EFX06321.1 - 1.1e-58 198.2 0.0 4.6e-57 193.0 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EFX06321.1 - 1.3e-10 40.5 0.1 8.8e-10 37.9 0.0 2.2 2 1 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.16 EFX06321.1 - 0.00097 18.4 0.0 0.3 10.2 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EFX06321.1 - 0.013 15.2 0.0 0.029 14.1 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family DLH PF01738.13 EFX06321.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF16 PF01519.11 EFX06322.1 - 0.055 13.6 0.8 0.082 13.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF1697 PF08002.6 EFX06322.1 - 0.11 12.5 0.5 0.24 11.4 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1697) SlyX PF04102.7 EFX06322.1 - 0.13 12.6 0.2 0.13 12.6 0.2 2.3 2 0 0 2 2 2 0 SlyX IFT57 PF10498.4 EFX06322.1 - 0.21 10.2 1.9 0.24 10.0 1.3 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF4407 PF14362.1 EFX06322.1 - 0.23 10.3 7.5 0.27 10.1 5.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Muted PF14942.1 EFX06322.1 - 0.54 10.1 6.4 2.1 8.2 4.1 1.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein MerR-DNA-bind PF09278.6 EFX06322.1 - 6.3 7.2 9.4 0.57 10.6 0.2 2.3 2 0 0 2 2 2 0 MerR, DNA binding Methyltransf_2 PF00891.13 EFX06323.1 - 2e-28 99.2 0.1 2.9e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase HET PF06985.6 EFX06323.1 - 1.9e-15 57.2 0.0 4.2e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FeoC PF09012.5 EFX06323.1 - 0.081 12.6 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 FeoC like transcriptional regulator HhH-GPD PF00730.20 EFX06324.1 - 1.3e-17 64.0 0.0 4e-17 62.4 0.0 1.9 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.1 EFX06324.1 - 1.7e-15 56.3 0.0 3.4e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.18 EFX06324.1 - 0.00021 20.7 0.6 0.00078 19.0 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.1 EFX06324.1 - 0.00086 19.4 0.0 0.11 12.7 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain Aconitase PF00330.15 EFX06325.1 - 6.3e-66 222.7 0.3 9.5e-41 139.7 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EFX06325.1 - 8.7e-27 93.8 0.0 1.6e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain JmjC PF02373.17 EFX06326.1 - 1.1e-36 125.5 0.3 2.2e-36 124.5 0.2 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.1 EFX06326.1 - 4.4e-19 68.5 4.5 8.2e-19 67.6 3.1 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EFX06326.1 - 2.3e-16 59.7 4.0 5e-16 58.6 2.8 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.12 EFX06326.1 - 4.2e-12 45.3 0.5 8.9e-12 44.3 0.4 1.6 1 0 0 1 1 1 1 jmjN domain HLH PF00010.21 EFX06327.1 - 1.4e-06 27.8 0.0 3e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain UDPGT PF00201.13 EFX06328.1 - 1.3e-11 43.7 0.0 1.8e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase MFS_1 PF07690.11 EFX06329.1 - 4.8e-46 157.0 31.0 4e-40 137.6 9.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX06329.1 - 5.6e-11 41.6 9.7 5.6e-11 41.6 6.7 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.8 EFX06329.1 - 9.5e-09 33.9 1.8 1.5e-08 33.3 1.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 EFX06329.1 - 0.022 12.8 0.2 0.39 8.6 0.7 2.1 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Septin PF00735.13 EFX06330.1 - 3e-110 367.6 0.4 3.5e-110 367.4 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EFX06330.1 - 9.8e-07 28.7 0.0 1.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 EFX06330.1 - 1e-05 24.7 0.0 1.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 AIG1 family DUF258 PF03193.11 EFX06330.1 - 6.4e-05 22.2 0.0 0.00012 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 EFX06330.1 - 0.00018 21.0 0.4 0.0028 17.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 EFX06330.1 - 0.0009 19.0 0.5 1.4 8.7 0.1 2.5 1 1 0 2 2 2 2 Dynamin family AAA_10 PF12846.2 EFX06330.1 - 0.0021 17.5 0.0 0.0025 17.3 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 EFX06330.1 - 0.0067 16.5 0.0 0.015 15.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EFX06330.1 - 0.014 15.7 0.6 0.021 15.1 0.3 1.7 1 1 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.7 EFX06330.1 - 0.018 14.1 0.1 0.057 12.5 0.0 1.8 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region NB-ARC PF00931.17 EFX06330.1 - 0.023 13.5 0.0 0.042 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 EFX06330.1 - 0.024 13.5 0.1 0.069 12.0 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.1 EFX06330.1 - 0.027 14.4 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.1 EFX06330.1 - 0.033 14.5 0.0 0.055 13.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EFX06330.1 - 0.038 13.4 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ras PF00071.17 EFX06330.1 - 0.07 12.5 0.0 0.19 11.0 0.0 1.7 1 0 0 1 1 1 0 Ras family Zeta_toxin PF06414.7 EFX06330.1 - 0.073 12.1 0.1 11 5.0 0.0 2.4 1 1 1 2 2 2 0 Zeta toxin AAA_29 PF13555.1 EFX06330.1 - 0.16 11.5 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.17 EFX06331.1 - 3.5e-18 65.5 0.0 5.7e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX06331.1 - 2.1e-10 41.1 0.0 3.8e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein DUF2416 PF10315.4 EFX06332.1 - 1.3e-05 25.4 0.0 2.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2416) RabGAP-TBC PF00566.13 EFX06333.1 - 1.1e-44 152.5 0.0 2.4e-44 151.3 0.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain HMA PF00403.21 EFX06334.1 - 6.2e-16 58.2 0.4 1.3e-15 57.2 0.2 1.5 2 0 0 2 2 2 1 Heavy-metal-associated domain IU_nuc_hydro PF01156.14 EFX06335.1 - 7.2e-38 130.5 0.0 8.5e-38 130.3 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Epimerase PF01370.16 EFX06336.1 - 8.4e-18 64.6 0.2 1.4e-17 63.9 0.2 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX06336.1 - 4.6e-13 49.5 1.7 1.1e-12 48.3 1.2 1.6 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX06336.1 - 7.5e-13 47.8 0.0 5.7e-12 44.9 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EFX06336.1 - 3.6e-12 45.7 0.3 1.4e-11 43.8 0.2 1.8 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EFX06336.1 - 3.5e-05 23.7 0.8 8.2e-05 22.5 0.3 1.9 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 EFX06336.1 - 6.9e-05 21.8 0.0 0.0001 21.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 EFX06336.1 - 0.002 18.5 0.0 0.0055 17.1 0.0 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.8 EFX06336.1 - 0.046 12.9 0.1 0.067 12.4 0.1 1.4 1 1 0 1 1 1 0 NmrA-like family HECT PF00632.20 EFX06337.1 - 9.2e-79 264.8 0.0 1.3e-78 264.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TraU PF06834.6 EFX06338.1 - 0.079 12.0 0.1 0.095 11.7 0.1 1.1 1 0 0 1 1 1 0 TraU protein Golgin_A5 PF09787.4 EFX06338.1 - 5.4 5.4 6.3 6.1 5.2 4.4 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 ADH_N PF08240.7 EFX06339.1 - 8.4e-31 105.9 0.5 1.5e-30 105.1 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EFX06339.1 - 2.3e-23 82.1 0.2 3.8e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SNF2_N PF00176.18 EFX06340.1 - 2.8e-10 39.4 0.0 4e-09 35.6 0.0 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EFX06340.1 - 8.5e-06 25.5 0.0 1.8e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EFX06340.1 - 0.1 12.1 0.0 0.65 9.4 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase Lsr2 PF11774.3 EFX06340.1 - 5 7.0 6.0 6.5 6.7 0.1 2.6 2 0 0 2 2 2 0 Lsr2 BING4CT PF08149.6 EFX06341.1 - 4.3e-40 135.0 0.0 2.6e-37 126.1 0.0 3.1 3 0 0 3 3 3 2 BING4CT (NUC141) domain WD40 PF00400.27 EFX06341.1 - 2e-11 43.2 0.2 8.1e-05 22.3 0.0 4.5 6 0 0 6 6 6 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EFX06341.1 - 0.00092 18.1 0.1 0.0018 17.1 0.0 1.4 2 0 0 2 2 2 1 Coatomer WD associated region DOCK-C2 PF14429.1 EFX06343.1 - 7.5e-19 68.0 0.0 1.5e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Ded_cyto PF06920.8 EFX06343.1 - 5.8e-08 32.2 0.0 3.6e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Dedicator of cytokinesis SH3_1 PF00018.23 EFX06343.1 - 0.0001 21.5 0.0 0.00022 20.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EFX06343.1 - 0.0098 15.4 0.1 0.052 13.1 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 EFX06343.1 - 0.084 12.3 0.0 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain APH PF01636.18 EFX06344.1 - 0.011 15.5 0.2 0.011 15.5 0.1 3.9 2 2 1 3 3 3 0 Phosphotransferase enzyme family Vfa1 PF08432.5 EFX06344.1 - 3.2 7.7 26.4 9.9 6.1 13.5 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Alpha-amylase_C PF02806.13 EFX06345.1 - 0.033 14.3 0.0 0.093 12.8 0.0 1.7 2 0 0 2 2 2 0 Alpha amylase, C-terminal all-beta domain Ribosomal_60s PF00428.14 EFX06345.1 - 0.15 12.5 0.9 0.27 11.6 0.6 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein His_Phos_1 PF00300.17 EFX06346.1 - 2.6e-20 73.1 0.5 9.9e-20 71.2 0.3 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 EFX06346.1 - 0.011 15.0 0.1 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Pyridoxal_deC PF00282.14 EFX06347.1 - 4.7e-73 245.7 0.0 7.3e-73 245.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain PPI_Ypi1 PF07491.6 EFX06349.1 - 3.3e-23 81.0 4.4 1.3e-22 79.1 3.1 2.1 1 1 0 1 1 1 1 Protein phosphatase inhibitor KH_1 PF00013.24 EFX06349.1 - 9.8e-10 37.9 0.1 9.3e-08 31.6 0.0 2.6 3 0 0 3 3 3 1 KH domain KH_3 PF13014.1 EFX06349.1 - 2.5e-06 27.0 1.3 2.1e-05 24.0 0.1 2.8 3 0 0 3 3 3 1 KH domain PAT1 PF09770.4 EFX06349.1 - 0.21 9.7 8.9 0.36 9.0 6.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1446 PF07287.6 EFX06350.1 - 5e-120 400.2 0.0 6.1e-120 399.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) Dynamin_N PF00350.18 EFX06352.1 - 1.4e-30 106.2 0.2 3.2e-30 105.1 0.2 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EFX06352.1 - 1e-13 50.7 0.1 2.8e-13 49.3 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 EFX06352.1 - 8.8e-06 25.6 0.6 0.00017 21.5 0.3 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase GED PF02212.13 EFX06352.1 - 0.00094 19.0 0.4 0.0062 16.4 0.0 2.7 3 1 0 3 3 3 1 Dynamin GTPase effector domain Miro PF08477.8 EFX06352.1 - 0.0086 16.5 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 EFX06352.1 - 0.029 13.6 0.1 7.8 5.7 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_21 PF13304.1 EFX06352.1 - 0.051 13.5 0.0 0.4 10.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain FliT PF05400.8 EFX06352.1 - 0.084 13.2 5.1 13 6.3 0.0 3.4 3 0 0 3 3 3 0 Flagellar protein FliT DUF1227 PF06777.6 EFX06354.1 - 2e-61 205.9 0.9 4.8e-61 204.7 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 EFX06354.1 - 3.5e-52 176.3 0.8 3.5e-52 176.3 0.5 1.6 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.1 EFX06354.1 - 1e-42 145.9 0.3 3.2e-42 144.3 0.0 2.0 3 0 0 3 3 3 1 Helicase C-terminal domain SNF2_N PF00176.18 EFX06354.1 - 0.00012 20.9 0.0 0.0019 17.0 0.0 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 EFX06354.1 - 0.0011 18.4 0.0 0.25 10.8 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_11 PF13086.1 EFX06354.1 - 0.0094 15.5 1.7 0.068 12.7 1.2 2.1 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 EFX06354.1 - 0.033 14.0 1.6 0.27 11.0 0.1 2.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.11 EFX06354.1 - 0.046 12.9 0.2 2.8 7.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein OmpH PF03938.9 EFX06354.1 - 0.083 12.8 0.0 0.083 12.8 0.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Smg4_UPF3 PF03467.10 EFX06355.1 - 2.1e-27 96.2 0.0 5.3e-27 94.9 0.0 1.7 1 0 0 1 1 1 1 Smg-4/UPF3 family RRM_1 PF00076.17 EFX06355.1 - 6.8e-07 28.8 0.3 1.6e-05 24.4 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX06355.1 - 4.4e-06 26.5 0.5 3.6e-05 23.6 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX06355.1 - 0.012 15.4 0.0 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIGA PF08288.7 EFX06356.1 - 9.3e-48 160.5 3.2 1.3e-47 160.1 0.7 2.2 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 EFX06356.1 - 3.6e-30 104.6 0.0 5.6e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EFX06356.1 - 2.1e-16 60.2 0.0 5.4e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EFX06356.1 - 2.9e-16 59.6 1.2 5.7e-16 58.7 0.3 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 EFX06356.1 - 7.6e-16 58.6 0.2 5.4e-15 55.8 0.0 2.6 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.1 EFX06356.1 - 7.8e-08 32.2 0.2 1.4e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 EFX06356.1 - 0.00015 21.9 0.0 0.00048 20.3 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 Leu_leader PF08054.6 EFX06357.1 - 0.6 9.7 0.2 0.6 9.7 0.2 2.5 3 0 0 3 3 3 0 Leucine operon leader peptide Ank_2 PF12796.2 EFX06358.1 - 3.1e-13 49.8 2.9 3.9e-07 30.3 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EFX06358.1 - 5.7e-08 32.7 3.4 2.1e-05 24.6 0.3 4.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX06358.1 - 1.2e-05 25.7 0.4 0.12 12.9 0.0 5.2 5 1 1 6 6 6 1 Ankyrin repeats (many copies) Ank PF00023.25 EFX06358.1 - 0.00044 19.9 0.2 0.00044 19.9 0.1 4.0 5 0 0 5 5 5 1 Ankyrin repeat Ank_3 PF13606.1 EFX06358.1 - 0.013 15.6 3.9 0.13 12.6 0.0 4.1 4 0 0 4 4 4 0 Ankyrin repeat EF-hand_4 PF12763.2 EFX06359.1 - 1.1e-29 102.1 0.0 1.1e-11 44.4 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 EFX06359.1 - 2.1e-07 30.9 0.0 0.00041 20.4 0.0 4.1 4 0 0 4 4 4 1 EF-hand domain pair IncA PF04156.9 EFX06359.1 - 8e-06 25.5 17.6 8e-06 25.5 12.2 2.4 1 1 1 2 2 2 2 IncA protein UBA PF00627.26 EFX06359.1 - 3.1e-05 23.6 0.0 7.4e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain WEMBL PF05701.6 EFX06359.1 - 0.00058 18.4 25.6 0.001 17.6 17.8 1.3 1 0 0 1 1 1 1 Weak chloroplast movement under blue light EF-hand_6 PF13405.1 EFX06359.1 - 0.0019 17.9 0.0 0.21 11.5 0.0 3.3 4 0 0 4 4 3 1 EF-hand domain EF-hand_1 PF00036.27 EFX06359.1 - 0.0022 17.1 0.0 3.8 7.0 0.0 3.7 3 0 0 3 3 3 1 EF hand CENP-F_leu_zip PF10473.4 EFX06359.1 - 0.0027 17.5 9.0 0.0027 17.5 6.2 3.6 2 1 2 4 4 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BicD PF09730.4 EFX06359.1 - 0.0038 15.6 22.3 0.0074 14.7 15.4 1.3 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D TPR_MLP1_2 PF07926.7 EFX06359.1 - 0.0039 16.9 36.3 0.031 14.0 15.7 2.6 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein ATG16 PF08614.6 EFX06359.1 - 0.0055 16.5 18.6 0.0055 16.5 12.9 2.8 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.14 EFX06359.1 - 0.011 13.5 27.8 0.014 13.1 11.5 2.0 1 1 1 2 2 2 0 Myosin tail DUF869 PF05911.6 EFX06359.1 - 0.032 12.4 23.8 0.05 11.8 16.5 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) GAS PF13851.1 EFX06359.1 - 0.06 12.5 33.0 0.021 14.0 10.0 2.7 2 1 0 3 3 2 0 Growth-arrest specific micro-tubule binding DUF4201 PF13870.1 EFX06359.1 - 0.23 10.9 26.8 0.81 9.0 3.6 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) Spc7 PF08317.6 EFX06359.1 - 0.25 9.9 29.7 0.25 9.9 3.4 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.6 EFX06359.1 - 0.26 11.2 14.5 2.2 8.2 0.1 4.7 4 1 2 6 6 5 0 Flagella accessory protein C (FlaC) Lebercilin PF15619.1 EFX06359.1 - 0.4 10.0 31.5 0.63 9.4 21.8 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.7 EFX06359.1 - 0.46 10.2 14.9 0.016 15.0 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3584 PF12128.3 EFX06359.1 - 0.79 6.9 28.3 1.3 6.2 19.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Seryl_tRNA_N PF02403.17 EFX06359.1 - 0.96 9.4 26.3 10 6.1 4.0 3.5 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain MAD PF05557.8 EFX06359.1 - 1.2 7.1 27.5 2.1 6.3 19.1 1.3 1 0 0 1 1 1 0 Mitotic checkpoint protein Filament PF00038.16 EFX06359.1 - 1.3 8.4 28.1 31 3.8 18.9 2.4 1 1 0 1 1 1 0 Intermediate filament protein CENP-Q PF13094.1 EFX06359.1 - 1.3 9.0 36.8 0.2 11.7 3.0 3.6 1 1 2 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF812 PF05667.6 EFX06359.1 - 1.8 6.9 35.1 0.26 9.7 17.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF812) Rab5-bind PF09311.6 EFX06359.1 - 2.6 7.9 32.7 6 6.7 2.3 3.5 2 1 1 3 3 3 0 Rabaptin-like protein NYD-SP28_assoc PF14775.1 EFX06359.1 - 2.6 7.8 6.1 0.59 9.8 1.4 2.0 2 0 0 2 2 2 0 Sperm tail C-terminal domain Mnd1 PF03962.10 EFX06359.1 - 5 6.7 29.5 2.2 7.8 6.4 2.3 1 1 1 2 2 2 0 Mnd1 family ADIP PF11559.3 EFX06359.1 - 5.4 6.9 38.9 4.6 7.1 7.6 4.1 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.1 EFX06359.1 - 5.4 5.3 22.2 2.4 6.5 6.6 2.0 1 1 1 2 2 2 0 AAA domain APG6 PF04111.7 EFX06359.1 - 7.1 5.5 32.1 0.84 8.6 13.7 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF2400 PF09674.5 EFX06359.1 - 8.6 5.9 7.5 11 5.5 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) DASH_Dad1 PF08649.5 EFX06360.1 - 1.4e-23 82.3 0.6 1.8e-23 81.9 0.4 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 Epimerase PF01370.16 EFX06361.1 - 1.4e-17 63.8 0.0 1.9e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EFX06361.1 - 1.4e-13 51.3 0.3 2.8e-13 50.2 0.2 1.5 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EFX06361.1 - 3.5e-08 32.4 0.0 6.1e-08 31.6 0.0 1.4 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 EFX06361.1 - 1.6e-07 30.8 0.2 2.9e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 EFX06361.1 - 7e-05 21.8 0.1 0.00021 20.3 0.1 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EFX06361.1 - 0.00017 20.5 0.0 0.0004 19.3 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein adh_short PF00106.20 EFX06361.1 - 0.00022 21.1 4.0 0.0021 17.9 2.8 2.1 1 1 0 1 1 1 1 short chain dehydrogenase DFP PF04127.10 EFX06361.1 - 0.027 14.0 0.1 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DapB_N PF01113.15 EFX06361.1 - 0.041 13.8 0.1 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 EFX06361.1 - 0.048 14.0 0.3 0.13 12.6 0.1 1.8 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 EFX06361.1 - 0.067 13.1 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain KR PF08659.5 EFX06361.1 - 0.089 12.4 2.3 0.58 9.7 1.6 2.1 1 1 0 1 1 1 0 KR domain Cupredoxin_1 PF13473.1 EFX06362.1 - 0.0073 16.1 0.1 0.02 14.7 0.0 1.7 2 0 0 2 2 2 1 Cupredoxin-like domain Copper-bind PF00127.15 EFX06362.1 - 0.05 13.8 0.3 0.13 12.4 0.2 1.7 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Cu_bind_like PF02298.12 EFX06362.1 - 0.076 12.8 0.6 0.27 11.0 0.4 1.9 1 1 0 1 1 1 0 Plastocyanin-like domain MGC-24 PF05283.6 EFX06362.1 - 1.2 8.9 18.8 0.14 11.9 9.9 1.7 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24) Macoilin PF09726.4 EFX06362.1 - 1.2 7.3 6.0 1.4 7.0 4.2 1.1 1 0 0 1 1 1 0 Transmembrane protein Pex14_N PF04695.8 EFX06362.1 - 2.1 8.3 6.9 2.7 8.0 2.3 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MSP1_C PF07462.6 EFX06362.1 - 5.2 5.3 9.3 7.8 4.7 6.4 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Dapper PF15268.1 EFX06362.1 - 5.9 5.5 11.6 7.4 5.2 8.0 1.1 1 0 0 1 1 1 0 Dapper DUF755 PF05501.6 EFX06362.1 - 6.2 6.8 13.9 9.1 6.3 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) NAD_binding_10 PF13460.1 EFX06364.1 - 4.3e-11 43.1 0.0 6.5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EFX06364.1 - 5.7e-07 29.0 0.0 3.3e-06 26.5 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family F420_oxidored PF03807.12 EFX06364.1 - 0.00047 20.5 0.0 0.0017 18.7 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 EFX06364.1 - 0.0012 18.8 0.1 0.0048 16.8 0.0 1.9 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.1 EFX06364.1 - 0.004 17.3 0.4 0.041 14.1 0.0 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding ApbA PF02558.11 EFX06364.1 - 0.0082 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Epimerase PF01370.16 EFX06364.1 - 0.018 14.5 0.0 3.2 7.1 0.0 2.3 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family XdhC_C PF13478.1 EFX06364.1 - 0.044 14.0 0.1 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 XdhC Rossmann domain Rossmann-like PF10727.4 EFX06364.1 - 0.054 13.2 0.2 0.2 11.3 0.1 2.0 2 1 1 3 3 3 0 Rossmann-like domain ELFV_dehydrog PF00208.16 EFX06364.1 - 0.07 12.6 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Methyltransf_23 PF13489.1 EFX06365.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain HXXSHH PF07586.6 EFX06367.1 - 0.33 9.8 2.4 0.59 9.0 1.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1552) Kp4 PF09044.5 EFX06369.1 - 4.5e-21 74.9 7.3 4.5e-21 74.9 5.0 1.7 2 0 0 2 2 2 1 Kp4 MU117 PF15474.1 EFX06369.1 - 0.27 11.7 5.1 0.47 10.9 3.5 1.4 1 0 0 1 1 1 0 Meiotically up-regulated gene family Aldo_ket_red PF00248.16 EFX06370.1 - 4.3e-50 170.1 0.0 5e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ENOD93 PF03386.9 EFX06371.1 - 2.3 7.9 11.1 0.87 9.3 0.5 2.5 1 1 1 2 2 2 0 Early nodulin 93 ENOD93 protein IMS PF00817.15 EFX06372.1 - 1.4e-30 106.0 0.0 3e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C2 PF00168.25 EFX06372.1 - 2e-18 66.0 0.0 8.7e-12 44.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain MAPEG PF01124.13 EFX06373.1 - 1.8e-15 56.6 3.3 2.6e-15 56.1 2.3 1.3 1 0 0 1 1 1 1 MAPEG family Rxt3 PF08642.5 EFX06374.1 - 4.5e-10 39.7 0.0 1.4e-09 38.1 0.0 1.9 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 Peroxidase_2 PF01328.12 EFX06375.1 - 4.4e-07 28.8 0.4 1.8e-06 26.8 0.3 1.9 1 1 0 1 1 1 1 Peroxidase, family 2 NB-ARC PF00931.17 EFX06376.1 - 6.1e-14 51.5 0.0 1.4e-13 50.3 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.1 EFX06376.1 - 1.2e-06 28.6 0.2 7e-06 26.1 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain TPR_12 PF13424.1 EFX06376.1 - 1.2e-06 28.3 17.1 0.00029 20.7 2.6 4.5 2 1 2 4 4 4 3 Tetratricopeptide repeat AAA_22 PF13401.1 EFX06376.1 - 4.5e-05 23.6 0.0 0.00026 21.1 0.0 2.4 2 0 0 2 2 1 1 AAA domain TPR_11 PF13414.1 EFX06376.1 - 0.00016 21.2 9.0 0.00045 19.8 1.5 2.9 1 1 2 3 3 3 2 TPR repeat DUF629 PF04780.7 EFX06376.1 - 0.00027 19.6 3.5 0.00027 19.6 2.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF629) zf-C2H2_2 PF12756.2 EFX06376.1 - 0.00037 20.5 6.1 0.0011 19.0 4.2 1.9 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Arch_ATPase PF01637.13 EFX06376.1 - 0.00088 19.0 0.0 0.0019 17.9 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase TPR_10 PF13374.1 EFX06376.1 - 0.0017 18.2 19.4 2 8.4 0.1 6.1 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 EFX06376.1 - 0.018 15.6 13.8 0.61 10.8 0.2 5.9 4 1 2 6 6 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 EFX06376.1 - 0.037 13.9 0.3 0.037 13.9 0.2 3.7 4 0 0 4 4 2 0 Tetratricopeptide repeat UPF0547 PF10571.4 EFX06376.1 - 0.087 12.5 5.7 16 5.3 2.0 3.3 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-MIZ PF02891.15 EFX06376.1 - 0.25 10.8 4.0 7.7 6.1 0.1 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger TPR_7 PF13176.1 EFX06376.1 - 0.27 11.1 3.8 4.9 7.1 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EFX06376.1 - 0.43 10.2 4.4 1.2 8.9 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat zf-C2H2_4 PF13894.1 EFX06376.1 - 0.64 10.4 15.4 33 5.1 0.1 4.8 4 0 0 4 4 4 0 C2H2-type zinc finger TPR_16 PF13432.1 EFX06376.1 - 0.83 10.4 14.1 2 9.2 0.9 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-H2C2_2 PF13465.1 EFX06376.1 - 5.6 7.4 10.1 0.28 11.5 0.4 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.7 EFX06376.1 - 9.4 6.4 12.9 8.4 6.6 1.3 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding adh_short_C2 PF13561.1 EFX06377.1 - 5.1e-05 23.1 0.0 6.8e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RdRP PF05183.7 EFX06378.1 - 2.3e-156 521.8 0.0 2.9e-156 521.5 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF3533 PF12051.3 EFX06379.1 - 1.5e-48 165.4 0.4 2.3e-48 164.8 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Mur_ligase_M PF08245.7 EFX06379.1 - 8.6e-06 25.9 0.0 2.6e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Mur ligase middle domain Phage_head_chap PF11113.3 EFX06379.1 - 0.13 12.1 0.2 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 Head assembly gene product FAD_binding_6 PF00970.19 EFX06380.1 - 4.6e-30 103.6 0.0 7e-30 103.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EFX06380.1 - 1.6e-29 102.6 0.0 2.5e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EFX06380.1 - 3.1e-06 27.1 0.0 0.0001 22.2 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 EFX06380.1 - 1.8e-05 24.7 0.0 9.2e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Siderophore-interacting FAD-binding domain AAA_17 PF13207.1 EFX06381.1 - 0.0015 19.3 0.3 0.0073 17.1 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EFX06381.1 - 0.003 17.6 0.0 0.0091 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX06381.1 - 0.0033 17.4 0.2 0.016 15.1 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_10 PF12846.2 EFX06381.1 - 0.02 14.3 0.1 0.053 12.9 0.1 1.8 1 1 0 1 1 1 0 AAA-like domain LSM14 PF12701.2 EFX06382.1 - 7.8e-34 115.3 0.1 1.7e-33 114.3 0.0 1.6 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.5 EFX06382.1 - 1.2e-18 67.5 3.2 1.2e-18 67.5 2.2 1.8 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.1 EFX06382.1 - 0.00012 21.9 0.0 0.00026 20.8 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain ORC6 PF05460.8 EFX06383.1 - 1.6e-35 122.8 3.7 1e-33 116.9 0.3 2.2 2 0 0 2 2 2 2 Origin recognition complex subunit 6 (ORC6) AA_permease_2 PF13520.1 EFX06384.1 - 7.3e-37 126.9 47.8 8.9e-34 116.7 33.1 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EFX06384.1 - 1.4e-17 63.1 46.9 1.7e-15 56.3 32.5 2.0 1 1 0 1 1 1 1 Amino acid permease GAPT PF11770.3 EFX06384.1 - 0.2 11.3 0.1 0.4 10.3 0.1 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Abhydrolase_3 PF07859.8 EFX06385.1 - 3.5e-36 124.7 0.0 1.2e-25 90.2 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Fzo_mitofusin PF04799.8 EFX06386.1 - 0.34 10.2 0.4 0.49 9.7 0.3 1.1 1 0 0 1 1 1 0 fzo-like conserved region DAO PF01266.19 EFX06387.1 - 2.3e-41 141.9 10.0 2.6e-41 141.7 6.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX06387.1 - 3.8e-06 26.9 2.8 0.00057 19.8 2.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX06387.1 - 8.7e-05 22.4 0.6 8.7e-05 22.4 0.4 2.2 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EFX06387.1 - 0.00016 21.4 4.0 0.13 11.9 0.3 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.17 EFX06387.1 - 0.00072 18.5 6.5 0.067 12.0 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EFX06387.1 - 0.0029 16.5 1.3 0.021 13.7 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein 3HCDH_N PF02737.13 EFX06387.1 - 0.0036 16.9 1.8 0.0063 16.1 1.3 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 EFX06387.1 - 0.0068 15.8 3.6 0.013 14.9 2.5 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.22 EFX06387.1 - 0.011 16.1 1.9 0.025 14.9 1.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 EFX06387.1 - 0.041 14.1 0.0 0.088 13.0 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding GMC_oxred_N PF00732.14 EFX06387.1 - 0.11 11.6 0.0 4 6.5 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase K_oxygenase PF13434.1 EFX06387.1 - 0.16 10.8 0.0 0.36 9.6 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) ThiF PF00899.16 EFX06387.1 - 0.25 11.1 1.2 0.49 10.2 0.3 1.8 2 0 0 2 2 2 0 ThiF family Trp_halogenase PF04820.9 EFX06387.1 - 2.5 6.6 8.1 1.1 7.8 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase G-gamma PF00631.17 EFX06388.1 - 0.095 12.4 0.1 0.41 10.4 0.0 2.0 2 0 0 2 2 2 0 GGL domain Amidase PF01425.16 EFX06390.1 - 5.5e-47 160.6 1.9 6.9e-46 156.9 0.6 2.3 1 1 1 2 2 2 2 Amidase SOG2 PF10428.4 EFX06393.1 - 2.6e-94 316.4 0.0 2.6e-94 316.4 0.0 2.8 4 0 0 4 4 4 1 RAM signalling pathway protein LRR_8 PF13855.1 EFX06393.1 - 4.4e-17 61.5 3.7 2.1e-10 40.1 0.2 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 EFX06393.1 - 8e-16 57.2 4.0 7.1e-05 22.3 0.0 3.8 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EFX06393.1 - 1.8e-07 30.1 3.3 0.55 10.4 0.0 5.9 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 EFX06393.1 - 0.00051 19.7 2.1 45 4.8 0.0 5.1 4 0 0 4 4 4 0 Leucine rich repeat LRR_6 PF13516.1 EFX06393.1 - 0.034 14.2 0.6 71 3.9 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich repeat Med15 PF09606.5 EFX06393.1 - 0.12 10.6 33.8 0.22 9.6 23.5 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Cas_Csx8 PF09657.5 EFX06393.1 - 0.36 9.4 0.0 0.54 8.9 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Csx8 (Cas_Csx8) RIC3 PF15361.1 EFX06393.1 - 1.5 9.0 10.0 4.5 7.4 7.0 1.8 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 FlgN PF05130.7 EFX06394.1 - 0.096 12.9 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 FlgN protein Clat_adaptor_s PF01217.15 EFX06395.1 - 6.8e-42 142.5 0.0 2e-41 141.0 0.0 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Tetraspannin PF00335.15 EFX06396.1 - 6.4e-06 25.5 1.9 1.9e-05 24.0 1.3 1.9 1 1 0 1 1 1 1 Tetraspanin family DUF647 PF04884.9 EFX06398.1 - 6e-98 327.0 2.5 8.2e-98 326.5 1.7 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF3328 PF11807.3 EFX06399.1 - 5.8e-27 94.8 0.4 7.6e-27 94.4 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) RasGEF PF00617.14 EFX06400.1 - 9.8e-50 168.8 0.3 1.4e-49 168.3 0.2 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EFX06400.1 - 8e-15 54.8 0.1 1.6e-14 53.8 0.1 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF974 PF06159.8 EFX06401.1 - 9e-78 261.1 0.0 1.9e-77 260.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF974) MMR_HSR1 PF01926.18 EFX06401.1 - 0.00032 20.6 0.0 0.0012 18.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gryzun PF07919.7 EFX06401.1 - 0.04 12.2 0.0 0.062 11.6 0.0 1.2 1 0 0 1 1 1 0 Gryzun, putative trafficking through Golgi PocR PF10114.4 EFX06402.1 - 0.16 11.0 0.3 0.33 10.0 0.2 1.5 1 0 0 1 1 1 0 Sensory domain found in PocR DUF445 PF04286.7 EFX06402.1 - 0.59 9.5 17.3 1.3 8.4 11.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF445) SseC PF04888.7 EFX06402.1 - 1.2 8.4 13.1 0.031 13.6 4.4 1.8 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF3533 PF12051.3 EFX06402.1 - 4.4 5.9 3.5 8.2 5.0 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF917 PF06032.7 EFX06405.1 - 2e-105 352.2 2.9 2.2e-105 352.1 0.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 EFX06405.1 - 2.8e-50 171.0 12.5 8.9e-48 162.8 5.8 2.4 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EFX06405.1 - 6.9e-29 100.5 0.3 1.6e-27 96.1 0.0 2.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Shikimate_dh_N PF08501.6 EFX06405.1 - 0.0051 16.8 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain StbA PF06406.6 EFX06405.1 - 0.05 12.5 1.2 1.3 7.8 0.1 3.3 3 0 0 3 3 3 0 StbA protein Lysine_decarbox PF03641.9 EFX06406.1 - 1.7e-29 102.3 0.0 2.2e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase HyaE PF07449.6 EFX06406.1 - 0.043 13.7 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE COX7C PF02935.11 EFX06409.1 - 3.2e-10 39.6 0.4 5.1e-10 39.0 0.3 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc IPK PF03770.11 EFX06410.1 - 4.5e-55 186.3 0.0 7.8e-55 185.5 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Ycf54 PF10674.4 EFX06410.1 - 0.032 14.3 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Pam17 PF08566.5 EFX06410.1 - 0.19 11.4 0.3 0.59 9.8 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 zf-C2H2_4 PF13894.1 EFX06411.1 - 7.8e-08 32.1 10.7 0.00027 21.0 0.9 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX06411.1 - 2.2e-05 24.5 1.2 2.2e-05 24.5 0.8 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2HC_2 PF13913.1 EFX06411.1 - 0.002 17.7 2.0 0.0042 16.7 1.4 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.1 EFX06411.1 - 0.0023 18.1 5.2 0.0023 18.1 3.6 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 EFX06411.1 - 0.0073 16.4 0.5 0.026 14.7 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EFX06411.1 - 0.011 15.5 0.3 0.032 14.1 0.2 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger PyrI_C PF02748.10 EFX06411.1 - 0.026 13.9 0.2 0.047 13.1 0.2 1.4 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.3 EFX06411.1 - 0.081 13.1 0.1 0.081 13.1 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PAT1 PF09770.4 EFX06411.1 - 7.6 4.6 14.1 12 4.0 9.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HMGL-like PF00682.14 EFX06412.1 - 2.5e-34 118.9 4.4 3.2e-34 118.6 0.2 2.6 2 1 0 2 2 2 1 HMGL-like CN_hydrolase PF00795.17 EFX06412.1 - 1.1e-16 60.7 0.0 2.9e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase BPL_LplA_LipB PF03099.14 EFX06412.1 - 7.5e-16 58.2 0.0 1.8e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Methyltransf_23 PF13489.1 EFX06413.1 - 2.1e-18 66.5 0.0 3.9e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX06413.1 - 6.1e-11 42.6 0.0 1.1e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06413.1 - 9.2e-07 29.4 0.0 2.6e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX06413.1 - 1.3e-05 24.4 0.0 0.045 12.8 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 EFX06413.1 - 1.8e-05 25.1 0.0 0.00018 21.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX06413.1 - 0.0001 21.9 0.0 0.074 12.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.12 EFX06413.1 - 0.0012 17.9 0.0 0.0023 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 EFX06413.1 - 0.0016 18.7 0.0 0.0055 17.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EFX06413.1 - 0.0077 15.6 0.0 0.024 14.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.14 EFX06413.1 - 0.016 15.2 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 EFX06413.1 - 0.017 14.2 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 EFX06413.1 - 0.017 15.1 0.0 0.052 13.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 EFX06413.1 - 0.023 14.1 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF938 PF06080.7 EFX06413.1 - 0.092 12.2 0.0 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF938) MFS_1 PF07690.11 EFX06414.1 - 2.3e-46 158.1 54.9 2.3e-46 158.1 35.8 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX06414.1 - 5.1e-23 81.1 22.0 7.1e-23 80.6 15.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EFX06414.1 - 2.4e-13 49.4 33.7 1.3e-12 47.1 4.0 3.4 2 1 1 3 3 3 3 Sugar (and other) transporter Bromodomain PF00439.20 EFX06415.1 - 3e-13 49.4 0.0 6.3e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Myb_DNA-binding PF00249.26 EFX06416.1 - 1.9e-12 47.0 0.0 2.6e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX06416.1 - 0.022 14.8 3.6 0.94 9.6 0.4 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain LRR_4 PF12799.2 EFX06417.1 - 1e-27 95.2 17.2 1.5e-06 27.6 0.1 8.4 2 2 10 12 12 12 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EFX06417.1 - 2.6e-21 75.1 20.3 0.00014 21.5 0.0 6.6 3 1 6 9 9 9 8 Leucine rich repeat LRR_1 PF00560.28 EFX06417.1 - 1.2e-09 36.8 23.2 1 9.6 0.5 11.8 12 2 1 13 13 13 3 Leucine Rich Repeat LRR_7 PF13504.1 EFX06417.1 - 3.9e-07 29.2 34.8 1.1 9.7 0.1 12.1 13 0 0 13 13 13 3 Leucine rich repeat LRR_6 PF13516.1 EFX06417.1 - 1.1e-06 28.1 17.5 0.5 10.5 0.0 9.4 9 2 1 10 10 10 3 Leucine Rich repeat LRR_9 PF14580.1 EFX06417.1 - 2.8e-06 27.0 8.3 0.00082 18.9 0.4 3.2 1 1 0 3 3 3 2 Leucine-rich repeat FAD_binding_3 PF01494.14 EFX06419.1 - 9e-18 64.4 0.0 1.1e-09 37.8 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.19 EFX06419.1 - 6.4e-07 28.7 0.0 0.00015 21.0 0.1 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.19 EFX06419.1 - 1.4e-05 24.1 0.1 0.0066 15.3 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 EFX06419.1 - 0.008 16.5 0.4 3.4 8.1 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX06419.1 - 0.041 12.5 0.7 1.6 7.2 0.1 2.2 1 1 1 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.1 EFX06419.1 - 0.072 13.1 0.1 0.53 10.3 0.0 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RseC_MucC PF04246.7 EFX06419.1 - 0.087 12.4 1.5 0.18 11.3 0.2 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC p450 PF00067.17 EFX06420.1 - 6.2e-55 186.5 0.0 3.3e-54 184.1 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Stirrup PF09061.1 EFX06420.1 - 0.0044 16.9 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Stirrup Zn_clus PF00172.13 EFX06422.1 - 7.6e-06 25.7 4.7 1.5e-05 24.8 3.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta-lactamase PF00144.19 EFX06423.1 - 5.8e-36 124.1 3.4 8.9e-36 123.5 2.4 1.3 1 0 0 1 1 1 1 Beta-lactamase Rtt106 PF08512.7 EFX06425.1 - 2.6e-24 84.9 0.0 5.2e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like bPH_2 PF03703.9 EFX06425.1 - 0.038 14.0 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain AAA PF00004.24 EFX06427.1 - 3e-55 186.0 0.0 1.1e-38 132.4 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EFX06427.1 - 1.9e-11 44.2 0.8 0.00026 21.1 0.1 4.2 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EFX06427.1 - 2.3e-09 37.5 0.2 0.0011 19.0 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 EFX06427.1 - 3.9e-08 34.1 0.1 0.002 18.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.12 EFX06427.1 - 6.7e-08 32.0 0.0 9.2e-07 28.4 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.9 EFX06427.1 - 7e-08 32.2 0.0 0.0015 18.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EFX06427.1 - 2.4e-07 31.1 0.1 0.0028 17.9 0.0 2.8 2 1 1 3 3 2 2 AAA domain TIP49 PF06068.8 EFX06427.1 - 2.5e-07 29.7 0.0 0.0072 15.0 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 EFX06427.1 - 3.4e-07 30.2 0.0 0.028 14.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 EFX06427.1 - 4.6e-07 29.4 0.2 0.029 13.7 0.0 2.8 3 0 0 3 3 3 2 IstB-like ATP binding protein CDC48_N PF02359.13 EFX06427.1 - 8.1e-07 28.9 0.0 1.7e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EFX06427.1 - 1.5e-06 28.2 0.0 2.7e-05 24.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EFX06427.1 - 1.6e-06 28.0 0.0 0.058 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EFX06427.1 - 1.8e-06 27.6 8.3 0.022 14.5 0.1 4.5 5 1 0 5 5 5 2 Part of AAA domain Mg_chelatase PF01078.16 EFX06427.1 - 2.7e-06 26.6 0.1 0.0051 15.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 EFX06427.1 - 7.3e-06 25.1 0.1 0.064 12.3 0.1 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 EFX06427.1 - 9e-06 25.8 0.0 0.02 15.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.7 EFX06427.1 - 1.2e-05 25.0 1.7 0.062 12.9 0.1 3.7 3 1 0 3 3 3 1 NACHT domain PhoH PF02562.11 EFX06427.1 - 1.8e-05 24.0 0.6 0.03 13.5 0.0 2.8 3 0 0 3 3 3 2 PhoH-like protein AAA_28 PF13521.1 EFX06427.1 - 4.5e-05 23.4 0.0 0.26 11.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EFX06427.1 - 5.3e-05 22.6 2.5 0.35 10.2 0.0 4.0 2 2 2 4 4 4 2 AAA domain Arch_ATPase PF01637.13 EFX06427.1 - 0.00011 21.9 0.2 10 5.7 0.0 3.9 2 2 1 4 4 4 0 Archaeal ATPase AAA_24 PF13479.1 EFX06427.1 - 0.00023 20.8 0.8 0.14 11.7 0.2 2.5 2 0 0 2 2 2 1 AAA domain DEAD PF00270.24 EFX06427.1 - 0.00026 20.5 0.3 8.8 5.7 0.0 4.4 2 2 2 4 4 4 0 DEAD/DEAH box helicase Sigma54_activat PF00158.21 EFX06427.1 - 0.00027 20.4 0.0 0.68 9.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain KaiC PF06745.8 EFX06427.1 - 0.0003 19.9 0.5 0.062 12.4 0.1 2.6 3 0 0 3 3 3 1 KaiC NB-ARC PF00931.17 EFX06427.1 - 0.00034 19.5 0.4 0.48 9.2 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_30 PF13604.1 EFX06427.1 - 0.00038 20.0 0.0 0.36 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 EFX06427.1 - 0.00039 19.5 0.3 0.046 12.6 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.22 EFX06427.1 - 0.0008 19.7 0.4 0.057 13.7 0.0 2.5 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.7 EFX06427.1 - 0.00097 18.2 0.1 0.73 8.8 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Sigma54_activ_2 PF14532.1 EFX06427.1 - 0.0016 18.4 0.1 2.4 8.2 0.1 3.4 3 1 0 3 3 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.12 EFX06427.1 - 0.0022 16.9 0.0 0.45 9.3 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 UPF0079 PF02367.12 EFX06427.1 - 0.0045 16.6 0.1 1.5 8.5 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 ResIII PF04851.10 EFX06427.1 - 0.015 15.1 1.0 3.2 7.5 0.0 3.1 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit T2SE PF00437.15 EFX06427.1 - 0.017 14.0 0.0 3 6.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_11 PF13086.1 EFX06427.1 - 0.046 13.2 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.6 EFX06427.1 - 0.052 13.1 0.0 0.33 10.5 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 EFX06427.1 - 0.059 12.9 0.0 4.3 6.9 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain IPT PF01745.11 EFX06427.1 - 0.13 11.4 0.3 1.2 8.2 0.1 2.2 2 0 0 2 2 2 0 Isopentenyl transferase KTI12 PF08433.5 EFX06427.1 - 0.16 11.1 0.1 0.41 9.8 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 FAD_binding_3 PF01494.14 EFX06428.1 - 7.8e-17 61.3 0.0 4.8e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 EFX06428.1 - 6.7e-11 41.6 2.3 3.9e-05 22.7 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX06428.1 - 5.4e-06 26.3 0.5 3.8e-05 23.6 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX06428.1 - 2.7e-05 23.2 4.1 3.3e-05 22.9 2.1 1.5 1 1 1 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 EFX06428.1 - 5.8e-05 22.1 0.8 0.0002 20.4 0.6 1.8 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 EFX06428.1 - 7e-05 22.9 0.0 0.00019 21.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EFX06428.1 - 0.0042 17.0 0.9 0.01 15.7 0.6 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EFX06428.1 - 0.016 13.7 0.7 0.13 10.7 0.7 1.9 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.12 EFX06428.1 - 0.016 14.2 0.3 0.033 13.2 0.2 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.22 EFX06428.1 - 0.063 13.6 1.3 0.31 11.4 1.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX06428.1 - 0.09 11.6 2.1 0.16 10.8 1.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EFX06428.1 - 0.11 11.6 2.2 0.15 11.0 0.8 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Ceramidase PF05875.7 EFX06429.1 - 1.8e-47 161.7 5.4 2.7e-47 161.1 3.7 1.2 1 0 0 1 1 1 1 Ceramidase TrkA_C PF02080.16 EFX06430.1 - 0.05 13.1 0.2 3.5 7.2 0.0 2.1 2 0 0 2 2 2 0 TrkA-C domain Myco_19_kDa PF05481.7 EFX06430.1 - 0.13 12.1 9.6 0.44 10.3 0.8 2.0 2 0 0 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen AWPM-19 PF05512.6 EFX06430.1 - 0.21 11.5 0.1 0.21 11.5 0.1 1.8 1 1 1 2 2 2 0 AWPM-19-like family Sulfatase PF00884.18 EFX06431.1 - 3e-61 207.2 1.0 4.6e-61 206.6 0.7 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 EFX06431.1 - 0.00011 21.6 0.4 0.0076 15.6 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Abhydrolase_5 PF12695.2 EFX06432.1 - 1.9e-06 27.7 0.1 3.3e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EFX06432.1 - 0.00013 21.2 0.0 0.00025 20.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.4 EFX06432.1 - 0.00017 20.9 0.1 0.00032 20.0 0.1 1.5 1 1 0 1 1 1 1 Esterase PHB depolymerase AXE1 PF05448.7 EFX06432.1 - 0.00051 18.6 0.1 0.0022 16.5 0.1 1.8 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.8 EFX06432.1 - 0.0011 18.5 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 EFX06432.1 - 0.0057 15.9 0.0 0.014 14.6 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.15 EFX06432.1 - 0.006 16.0 0.0 0.0092 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Bromodomain PF00439.20 EFX06434.1 - 3.8e-36 122.8 0.4 9.3e-21 73.5 0.0 3.3 3 0 0 3 3 3 3 Bromodomain Hex_IIIa PF02455.11 EFX06434.1 - 5.5 5.5 7.6 0.16 10.5 0.0 2.2 2 1 1 3 3 3 0 Hexon-associated protein (IIIa) Microtub_assoc PF07989.6 EFX06435.1 - 0.0029 17.3 6.8 0.0066 16.2 4.7 1.7 1 0 0 1 1 1 1 Microtubule associated APG6 PF04111.7 EFX06435.1 - 2.7 6.9 7.1 4.4 6.2 5.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DNA_pol_A_exo1 PF01612.15 EFX06436.1 - 6.3e-07 29.0 0.0 9.8e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease AAA PF00004.24 EFX06437.1 - 5.2e-44 149.6 0.0 8.5e-44 148.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX06437.1 - 3.1e-08 33.4 0.0 7.5e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EFX06437.1 - 1.2e-07 31.7 0.0 2.2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EFX06437.1 - 3.3e-06 27.2 0.0 9.5e-06 25.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EFX06437.1 - 4.8e-06 26.7 0.1 0.00025 21.1 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX06437.1 - 6e-05 23.8 0.0 0.00015 22.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFX06437.1 - 7.6e-05 21.8 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EFX06437.1 - 0.00013 21.5 0.1 0.00029 20.5 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EFX06437.1 - 0.00042 19.7 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 EFX06437.1 - 0.00089 18.0 0.0 0.0016 17.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 EFX06437.1 - 0.0014 18.5 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFX06437.1 - 0.0017 18.2 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 EFX06437.1 - 0.0023 17.5 0.0 0.0074 15.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EFX06437.1 - 0.0024 17.0 0.0 0.0044 16.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.1 EFX06437.1 - 0.0038 17.2 0.0 0.0067 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX06437.1 - 0.0061 16.8 0.0 0.028 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EFX06437.1 - 0.0069 15.5 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI KaiC PF06745.8 EFX06437.1 - 0.0074 15.4 0.0 0.017 14.2 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 EFX06437.1 - 0.017 14.5 0.1 0.081 12.3 0.0 1.9 1 1 1 2 2 2 0 AAA domain DUF815 PF05673.8 EFX06437.1 - 0.018 13.9 0.0 0.033 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 EFX06437.1 - 0.019 14.4 0.0 0.085 12.3 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain PhoH PF02562.11 EFX06437.1 - 0.019 14.1 0.0 0.07 12.3 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.1 EFX06437.1 - 0.019 14.5 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EFX06437.1 - 0.029 14.5 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Histone PF00125.19 EFX06437.1 - 0.041 14.0 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Sigma54_activ_2 PF14532.1 EFX06437.1 - 0.047 13.7 0.0 0.12 12.4 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 EFX06437.1 - 0.05 12.4 0.0 0.086 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 EFX06437.1 - 0.078 11.8 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.7 EFX06437.1 - 0.1 12.2 0.0 0.53 9.9 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Patatin PF01734.17 EFX06438.1 - 7.2e-16 58.7 0.0 2.5e-15 56.9 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase Metallophos PF00149.23 EFX06441.1 - 1.6e-39 135.3 0.8 2.3e-39 134.8 0.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase JmjN PF02375.12 EFX06441.1 - 0.015 14.8 0.0 0.036 13.5 0.0 1.7 1 0 0 1 1 1 0 jmjN domain Glyco_hydro_12 PF01670.11 EFX06442.1 - 6.4e-35 120.2 0.6 1.5e-34 119.0 0.4 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 CBM_1 PF00734.13 EFX06442.1 - 2.7e-11 42.9 12.4 2.7e-11 42.9 8.6 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain SDA1 PF05285.7 EFX06443.1 - 7.9e-77 258.6 50.9 1e-76 258.2 32.3 2.7 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.7 EFX06443.1 - 5.9e-18 64.8 0.0 1.4e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 NUC130/3NT domain DUF1651 PF07864.6 EFX06443.1 - 0.04 14.0 0.3 0.12 12.4 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1651) Mito_carr PF00153.22 EFX06443.1 - 0.052 13.2 0.2 16 5.2 0.0 2.8 2 0 0 2 2 2 0 Mitochondrial carrier protein LRR_6 PF13516.1 EFX06446.1 - 0.062 13.3 2.3 30 5.1 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.28 EFX06446.1 - 1.6 9.0 6.2 35 4.9 0.0 4.8 5 1 0 5 5 5 0 Leucine Rich Repeat Y_phosphatase2 PF03162.8 EFX06447.1 - 1.5e-45 154.5 0.0 2.3e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EFX06447.1 - 3.1e-12 47.0 0.0 6.3e-11 42.7 0.0 2.3 1 1 1 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 EFX06447.1 - 0.0018 17.8 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EFX06447.1 - 0.0019 17.5 0.1 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MliC PF09864.4 EFX06447.1 - 0.0037 16.9 0.1 0.012 15.3 0.1 1.8 1 0 0 1 1 1 1 Membrane-bound lysozyme-inhibitor of c-type lysozyme DUF1768 PF08719.6 EFX06448.1 - 1.8e-44 151.2 0.1 2.3e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) COPI_C PF06957.6 EFX06448.1 - 0.017 13.7 0.0 0.023 13.2 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF544 PF04424.8 EFX06449.1 - 3.7e-13 49.3 0.0 6.1e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) GCN5L1 PF06320.8 EFX06450.1 - 1.7e-06 27.8 1.4 5e-06 26.3 1.0 1.8 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) IncA PF04156.9 EFX06450.1 - 0.024 14.2 0.2 0.059 12.9 0.2 1.7 1 0 0 1 1 1 0 IncA protein LysM PF01476.15 EFX06453.1 - 5.6e-23 80.5 1.1 6e-07 29.2 0.0 5.8 6 0 0 6 6 6 4 LysM domain ArsB PF02040.10 EFX06454.1 - 9.7e-11 41.2 29.3 3.7e-07 29.4 6.1 2.5 3 0 0 3 3 3 2 Arsenical pump membrane protein adh_short PF00106.20 EFX06455.1 - 1.7e-11 44.3 3.0 1.7e-11 44.3 2.1 1.9 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFX06455.1 - 0.00015 21.4 0.8 0.00028 20.6 0.5 1.4 1 0 0 1 1 1 1 KR domain cobW PF02492.14 EFX06456.1 - 4.8e-35 120.6 0.0 7e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 EFX06456.1 - 1.9e-05 23.6 0.5 0.021 13.5 0.1 2.1 2 0 0 2 2 2 2 ArgK protein AAA_23 PF13476.1 EFX06456.1 - 0.012 15.9 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 EFX06456.1 - 0.034 13.9 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit BNR PF02012.15 EFX06456.1 - 0.052 13.3 2.2 18 5.7 0.0 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat MMR_HSR1 PF01926.18 EFX06456.1 - 0.075 12.9 0.0 0.16 11.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 EFX06456.1 - 0.097 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pyr_redox_dim PF02852.17 EFX06457.1 - 1.3e-33 115.2 0.7 9.2e-33 112.5 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 EFX06457.1 - 7.4e-21 74.9 0.1 1.1e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Helicase_C PF00271.26 EFX06457.1 - 3.6e-18 65.1 0.0 2.4e-15 56.1 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain Pyr_redox PF00070.22 EFX06457.1 - 1.3e-16 60.7 0.0 4.8e-16 58.9 0.0 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DEAD PF00270.24 EFX06457.1 - 0.0002 20.8 0.0 0.00037 20.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pyr_redox_3 PF13738.1 EFX06457.1 - 0.00021 21.4 0.1 0.011 15.8 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EFX06457.1 - 0.026 13.4 0.0 0.045 12.6 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) OPT PF03169.10 EFX06458.1 - 2.1e-122 409.7 40.8 2.4e-122 409.5 28.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Methyltransf_23 PF13489.1 EFX06460.1 - 1.8e-21 76.5 0.0 3e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX06460.1 - 3.2e-10 39.7 0.0 2.5e-06 27.1 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06460.1 - 2e-08 34.7 0.0 9.6e-07 29.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX06460.1 - 2.8e-05 24.5 0.0 6.7e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX06460.1 - 0.019 15.4 0.0 0.2 12.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain CheR PF01739.13 EFX06460.1 - 0.04 13.1 0.0 0.079 12.2 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain SPX PF03105.14 EFX06461.1 - 3.4e-47 161.5 0.0 4.6e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 EFX06461.1 - 8.9e-36 123.7 34.2 1.3e-35 123.2 23.7 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 EFX06461.1 - 1.9e-11 43.1 21.2 1.9e-11 43.1 14.7 2.3 1 1 1 2 2 2 1 Citrate transporter DUF3702 PF12486.3 EFX06461.1 - 0.21 11.2 0.9 0.41 10.3 0.6 1.4 1 0 0 1 1 1 0 ImpA domain protein Mito_fiss_reg PF05308.6 EFX06461.1 - 0.44 9.8 4.0 0.86 8.9 2.8 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Fe-S_biosyn PF01521.15 EFX06462.1 - 1.6e-17 63.4 0.0 2.1e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Myb_DNA-binding PF00249.26 EFX06463.1 - 2.4e-29 101.1 0.1 2.5e-11 43.4 0.1 3.5 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EFX06463.1 - 4.7e-26 90.6 0.2 1.4e-09 37.8 0.0 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Rap1_C PF11626.3 EFX06463.1 - 0.01 15.7 0.5 1.7 8.5 0.3 3.0 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain HATPase_c PF02518.21 EFX06464.1 - 1.4e-05 24.7 0.0 2.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EFX06464.1 - 3.4e-05 23.5 0.0 6.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ADC PF06314.6 EFX06465.1 - 1.7e-42 145.4 0.0 2e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Zn_clus PF00172.13 EFX06466.1 - 0.0038 17.0 7.4 0.0086 15.9 5.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M28 PF04389.12 EFX06467.1 - 4.9e-22 78.5 0.0 8e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EFX06467.1 - 1.1e-12 47.5 1.2 2.4e-12 46.4 0.8 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 EFX06467.1 - 0.07 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DENN PF02141.16 EFX06468.1 - 2.1e-56 190.5 0.0 3.3e-56 189.9 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.14 EFX06468.1 - 1.7e-17 63.2 0.6 2.9e-17 62.4 0.4 1.4 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.13 EFX06468.1 - 1.9e-17 62.9 0.0 3.8e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 uDENN domain SPA PF08616.5 EFX06468.1 - 0.1 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Stabilization of polarity axis PHD PF00628.24 EFX06468.1 - 0.58 9.8 9.8 1.5 8.5 6.8 1.7 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.17 EFX06468.1 - 0.67 9.7 10.6 1.3 8.8 7.4 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) COesterase PF00135.23 EFX06469.1 - 3.9e-85 286.5 0.0 5.2e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EFX06469.1 - 0.14 11.7 1.2 0.55 9.7 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold ERCC4 PF02732.10 EFX06470.1 - 1.7e-11 44.0 0.0 3.9e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain Vmethyltransf_C PF08456.5 EFX06470.1 - 0.029 13.7 1.9 0.048 13.0 1.3 1.3 1 0 0 1 1 1 0 Viral methyltransferase C-terminal RNase_H2-Ydr279 PF09468.5 EFX06470.1 - 0.21 10.7 4.6 0.38 9.8 3.2 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Borrelia_P83 PF05262.6 EFX06470.1 - 0.67 8.1 13.3 1 7.5 9.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Ycf1 PF05758.7 EFX06470.1 - 3.2 5.3 6.9 4.6 4.8 4.8 1.1 1 0 0 1 1 1 0 Ycf1 CBM-like PF14683.1 EFX06471.1 - 9.6e-32 109.9 0.0 2.1e-31 108.8 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 EFX06471.1 - 2.5e-21 75.5 2.7 2.9e-21 75.4 0.4 2.1 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.1 EFX06471.1 - 3.1e-10 39.9 0.9 8.9e-10 38.4 0.6 1.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4480 PF13715.1 EFX06471.1 - 1.5e-05 24.9 0.1 0.00023 21.1 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4480) phage_tail_N PF08400.5 EFX06471.1 - 0.0039 16.8 0.3 0.0071 16.0 0.2 1.3 1 0 0 1 1 1 1 Prophage tail fibre N-terminal DUF4198 PF10670.4 EFX06471.1 - 0.015 15.3 0.1 0.042 13.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4198) DUF2012 PF09430.5 EFX06471.1 - 0.084 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Pirin PF02678.11 EFX06472.1 - 2e-31 108.0 0.0 3.6e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 EFX06472.1 - 2.4e-23 82.1 0.0 1.5e-21 76.4 0.0 2.3 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 EFX06472.1 - 4.8e-07 29.1 1.5 4.6e-06 26.0 0.3 2.6 2 1 0 2 2 2 1 Cupin domain Cupin_3 PF05899.7 EFX06472.1 - 0.017 14.4 0.1 0.26 10.7 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF861) DS PF01916.12 EFX06473.1 - 3.5e-143 476.1 0.0 4.1e-143 475.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase CmcH_NodU PF02543.10 EFX06473.1 - 0.056 12.5 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase V-SNARE PF05008.10 EFX06474.1 - 8.9e-23 80.2 0.7 2.5e-22 78.8 0.5 1.8 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 EFX06474.1 - 1e-18 67.1 3.0 3e-18 65.6 2.1 1.9 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF726 PF05277.7 EFX06474.1 - 1.2e-16 60.5 0.0 1.9e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Sec20 PF03908.8 EFX06474.1 - 0.0086 15.7 0.8 0.022 14.4 0.5 1.7 1 0 0 1 1 1 1 Sec20 Synaptobrevin PF00957.16 EFX06474.1 - 0.039 13.5 0.3 0.039 13.5 0.2 1.8 2 0 0 2 2 2 0 Synaptobrevin TBCA PF02970.11 EFX06474.1 - 0.12 12.4 4.4 3 7.9 0.2 3.2 3 1 0 3 3 3 0 Tubulin binding cofactor A OppC_N PF12911.2 EFX06474.1 - 0.23 10.8 2.8 0.54 9.6 1.9 1.7 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Fusion_gly PF00523.13 EFX06474.1 - 0.29 9.1 2.2 0.42 8.6 0.4 1.9 2 0 0 2 2 2 0 Fusion glycoprotein F0 Myosin_tail_1 PF01576.14 EFX06474.1 - 1.6 6.3 9.2 2.2 5.8 0.6 2.1 2 0 0 2 2 2 0 Myosin tail DUF1674 PF07896.7 EFX06475.1 - 2.1e-14 53.4 1.5 3.5e-14 52.7 1.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Cu_amine_oxid PF01179.15 EFX06476.1 - 9.3e-159 528.5 0.0 1.2e-158 528.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain SGL PF08450.7 EFX06476.1 - 1.3e-44 152.4 0.3 2e-44 151.8 0.2 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Cu_amine_oxidN2 PF02727.11 EFX06476.1 - 1.6e-09 37.6 0.0 3.6e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Amnionless PF14828.1 EFX06478.1 - 0.0092 14.5 0.0 0.0099 14.4 0.0 1.1 1 0 0 1 1 1 1 Amnionless HemY_N PF07219.8 EFX06478.1 - 0.0092 15.5 0.0 0.0092 15.5 0.0 2.3 2 1 1 3 3 3 1 HemY protein N-terminus DUF2453 PF10507.4 EFX06478.1 - 0.14 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2453) Ctr PF04145.10 EFX06478.1 - 0.23 11.4 0.6 1.3 9.0 0.0 2.1 1 1 1 2 2 2 0 Ctr copper transporter family Podoplanin PF05808.6 EFX06478.1 - 0.69 9.4 2.9 13 5.3 0.5 2.2 2 0 0 2 2 2 0 Podoplanin Striatin PF08232.7 EFX06479.1 - 6.4e-34 117.1 0.2 1.3e-33 116.1 0.2 1.6 1 0 0 1 1 1 1 Striatin family WD40 PF00400.27 EFX06479.1 - 4.4e-30 102.4 20.1 4.6e-07 29.4 0.0 7.7 7 1 0 7 7 7 5 WD domain, G-beta repeat SlyX PF04102.7 EFX06479.1 - 0.049 14.0 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 SlyX Myosin_tail_1 PF01576.14 EFX06479.1 - 0.093 10.4 3.7 0.13 9.9 2.6 1.0 1 0 0 1 1 1 0 Myosin tail Trypan_PARP PF05887.6 EFX06481.1 - 0.0019 18.0 27.6 0.0044 16.8 19.1 1.6 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Neisseria_TspB PF05616.8 EFX06481.1 - 0.14 10.4 15.6 0.22 9.8 10.8 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Herpes_DNAp_acc PF04929.7 EFX06481.1 - 0.24 10.3 7.9 0.34 9.8 5.5 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Rrn6 PF10214.4 EFX06481.1 - 2.2 6.3 6.4 2.9 5.8 4.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor RR_TM4-6 PF06459.7 EFX06481.1 - 4.5 7.0 6.6 7.8 6.3 4.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Fungal_trans PF04082.13 EFX06482.1 - 3.3e-20 72.0 0.0 4.7e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06482.1 - 4.9e-07 29.5 7.0 9.7e-07 28.6 4.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4050 PF13259.1 EFX06483.1 - 9.7e-31 106.2 0.4 2.8e-30 104.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) EF-hand_6 PF13405.1 EFX06484.1 - 9.2e-08 31.3 0.0 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 EFX06484.1 - 4.8e-06 25.6 0.1 6.3e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.27 EFX06484.1 - 0.00028 19.9 0.7 0.0062 15.7 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 EFX06484.1 - 0.00037 20.5 0.2 0.0013 18.8 0.2 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 EFX06484.1 - 0.0024 17.4 0.1 0.18 11.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair Methyltransf_23 PF13489.1 EFX06485.1 - 5.9e-20 71.6 0.0 9.1e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX06485.1 - 9.4e-16 58.0 0.0 2.1e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX06485.1 - 1.2e-10 41.7 0.0 9.9e-10 38.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX06485.1 - 1.3e-10 41.0 0.0 4.7e-09 35.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06485.1 - 5.8e-10 39.7 0.0 1.8e-08 34.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX06485.1 - 2.1e-07 30.3 0.0 7.1e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX06485.1 - 8.8e-07 29.2 0.0 4.3e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EFX06485.1 - 5.4e-05 23.2 0.0 0.0002 21.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX06485.1 - 0.0031 16.5 0.0 0.0095 15.0 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.14 EFX06485.1 - 0.0071 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 EFX06485.1 - 0.017 14.4 0.0 0.1 11.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.4 EFX06485.1 - 0.029 13.8 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF938 PF06080.7 EFX06485.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_8 PF05148.10 EFX06485.1 - 0.12 11.9 0.0 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase PNP_UDP_1 PF01048.15 EFX06486.1 - 1.5e-14 53.5 2.3 1.9e-13 49.9 1.6 2.4 1 1 0 1 1 1 1 Phosphorylase superfamily DUF3328 PF11807.3 EFX06487.1 - 4.7e-26 91.8 0.1 6.8e-26 91.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) GET2 PF08690.5 EFX06488.1 - 3e-11 43.1 0.0 1.3e-06 27.9 0.0 2.3 2 0 0 2 2 2 2 GET complex subunit GET2 NUC173 PF08161.7 EFX06489.1 - 4.5e-65 218.7 0.0 9.6e-64 214.3 0.0 2.8 3 0 0 3 3 3 1 NUC173 domain HEAT PF02985.17 EFX06489.1 - 0.0084 16.1 4.2 1.9 8.8 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 EFX06489.1 - 0.033 14.4 17.6 0.037 14.3 0.7 5.2 5 1 1 6 6 5 0 HEAT repeats Nucleo_P87 PF07267.6 EFX06489.1 - 0.77 8.3 0.2 1.3 7.6 0.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 BUD22 PF09073.5 EFX06489.1 - 0.93 8.4 10.4 2.4 7.1 7.2 1.6 1 0 0 1 1 1 0 BUD22 DUF2419 PF10343.4 EFX06490.1 - 2.4e-128 427.4 0.0 2.8e-128 427.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2419) Peptidase_M1 PF01433.15 EFX06492.1 - 1.8e-124 415.7 0.0 2.9e-124 415.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EFX06492.1 - 1.2e-56 192.3 0.1 3.6e-56 190.7 0.0 1.8 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EFX06492.1 - 9.4e-22 77.4 2.9 4.9e-21 75.1 0.3 2.7 1 1 1 2 2 2 1 Peptidase MA superfamily DUF45 PF01863.12 EFX06492.1 - 0.22 11.3 0.1 0.72 9.6 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF45 Fungal_trans PF04082.13 EFX06493.1 - 2e-22 79.3 0.0 3.5e-21 75.2 0.0 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06493.1 - 2.6e-09 36.8 9.6 4.5e-09 36.0 6.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Thr_synth_N PF14821.1 EFX06494.1 - 1.3e-27 95.6 0.0 3e-27 94.4 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 EFX06494.1 - 6.7e-20 71.5 0.1 2.3e-18 66.4 0.1 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Clr5 PF14420.1 EFX06495.1 - 1.4e-10 40.8 0.0 2.5e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Clr5 domain Meleagrin PF08189.6 EFX06496.1 - 0.031 13.7 2.5 0.032 13.7 0.5 1.9 2 0 0 2 2 2 0 Meleagrin/Cygnin family DUF1180 PF06679.7 EFX06496.1 - 0.035 13.9 1.1 0.054 13.3 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) CorA PF01544.13 EFX06497.1 - 1e-06 28.0 0.9 3e-06 26.4 0.7 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein HCV_NS2 PF01538.13 EFX06497.1 - 0.036 13.4 0.1 0.094 12.1 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 Fungal_trans PF04082.13 EFX06499.1 - 2.5e-09 36.4 0.0 5.8e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06499.1 - 1.8e-07 30.9 9.3 1.8e-07 30.9 6.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HEAT_2 PF13646.1 EFX06500.1 - 4.1e-24 84.6 34.3 3.1e-10 40.1 2.1 5.0 1 1 3 5 5 5 4 HEAT repeats NACHT PF05729.7 EFX06500.1 - 1.9e-17 63.4 0.0 4.4e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Cnd1 PF12717.2 EFX06500.1 - 2.9e-08 33.7 0.1 0.25 11.1 0.0 5.2 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 EFX06500.1 - 7.3e-07 29.4 28.3 0.014 15.9 0.7 7.3 4 2 3 8 8 7 4 HEAT-like repeat HEAT PF02985.17 EFX06500.1 - 2.2e-06 27.2 14.7 2.8 8.2 0.0 8.3 8 0 0 8 8 7 1 HEAT repeat NB-ARC PF00931.17 EFX06500.1 - 9e-06 24.7 0.0 2.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Adaptin_N PF01602.15 EFX06500.1 - 0.00013 20.4 8.9 0.22 9.7 0.2 3.3 1 1 2 3 3 3 3 Adaptin N terminal region AAA_18 PF13238.1 EFX06500.1 - 0.0011 19.3 0.0 0.0048 17.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EFX06500.1 - 0.0012 19.6 0.0 0.0089 16.8 0.0 2.6 2 0 0 2 2 1 1 AAA domain CTP_transf_3 PF02348.14 EFX06500.1 - 0.0014 18.2 1.6 0.15 11.6 0.1 2.6 1 1 1 2 2 2 1 Cytidylyltransferase AAA_22 PF13401.1 EFX06500.1 - 0.0019 18.3 0.1 0.034 14.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 EFX06500.1 - 0.0036 17.5 0.0 0.017 15.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EFX06500.1 - 0.0046 16.8 0.0 0.029 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 EFX06500.1 - 0.041 13.5 1.1 0.13 12.0 0.1 2.2 2 1 1 3 3 3 0 NTPase Cohesin_HEAT PF12765.2 EFX06500.1 - 0.073 13.0 13.8 3.8 7.5 0.6 5.9 7 0 0 7 7 7 0 HEAT repeat associated with sister chromatid cohesion AAA_16 PF13191.1 EFX06500.1 - 0.073 13.0 0.2 0.073 13.0 0.1 3.9 2 2 0 2 2 2 0 AAA ATPase domain Arm PF00514.18 EFX06500.1 - 0.096 12.5 1.0 33 4.5 0.1 4.5 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat AAA_24 PF13479.1 EFX06500.1 - 0.11 12.0 0.3 0.53 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF1992 PF09350.5 EFX06501.1 - 8.3e-22 76.8 0.1 2e-21 75.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) Synaphin PF05835.7 EFX06501.1 - 0.052 13.7 0.4 0.13 12.4 0.1 1.8 2 0 0 2 2 2 0 Synaphin protein MgsA_C PF12002.3 EFX06502.1 - 8.3e-59 198.0 0.0 1.6e-58 197.1 0.0 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.24 EFX06502.1 - 6.2e-14 52.3 0.0 1.2e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EFX06502.1 - 3e-10 39.5 0.0 5.4e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Sigma54_activat PF00158.21 EFX06502.1 - 3.2e-07 29.9 0.1 1.7e-05 24.3 0.0 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.1 EFX06502.1 - 3.5e-05 23.9 0.2 0.00015 21.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EFX06502.1 - 4e-05 22.8 0.1 0.065 12.3 0.0 2.3 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 EFX06502.1 - 0.00011 22.0 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EFX06502.1 - 0.00017 21.6 0.3 0.013 15.4 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 EFX06502.1 - 0.00031 20.5 0.0 0.0017 18.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EFX06502.1 - 0.00041 20.0 0.0 0.0015 18.2 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain DUF815 PF05673.8 EFX06502.1 - 0.0005 19.0 0.0 0.00078 18.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.8 EFX06502.1 - 0.0024 16.6 0.0 0.0059 15.3 0.0 1.5 2 0 0 2 2 2 1 TIP49 C-terminus AAA_3 PF07726.6 EFX06502.1 - 0.0037 16.8 0.0 0.013 15.1 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 EFX06502.1 - 0.0063 16.5 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain NB-ARC PF00931.17 EFX06502.1 - 0.021 13.7 0.0 0.033 13.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain DNA_pol3_delta2 PF13177.1 EFX06502.1 - 0.021 14.5 0.0 0.91 9.1 0.0 2.3 1 1 1 2 2 2 0 DNA polymerase III, delta subunit AAA_10 PF12846.2 EFX06502.1 - 0.026 13.9 0.0 3.8 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 EFX06502.1 - 0.036 14.8 0.0 0.082 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain SKI PF01202.17 EFX06502.1 - 0.04 13.7 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate kinase ResIII PF04851.10 EFX06502.1 - 0.044 13.6 0.2 6 6.6 0.0 2.5 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit CPT PF07931.7 EFX06502.1 - 0.049 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.1 EFX06502.1 - 0.087 12.7 0.1 0.2 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain Pho88 PF10032.4 EFX06503.1 - 8.8e-80 266.4 0.0 9.8e-80 266.3 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) TMEMspv1-c74-12 PF11044.3 EFX06503.1 - 0.25 10.9 1.2 0.72 9.4 0.1 2.2 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Atg8 PF02991.11 EFX06504.1 - 9e-51 170.1 0.2 1.1e-50 169.9 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 EFX06504.1 - 3.1e-07 30.4 0.0 3.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Band_7 PF01145.20 EFX06505.1 - 9.8e-27 94.0 2.9 1.5e-26 93.3 2.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 EFX06505.1 - 0.025 14.1 0.3 0.04 13.4 0.2 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Pyr_redox_3 PF13738.1 EFX06506.1 - 9.6e-27 94.3 0.0 1.4e-25 90.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX06506.1 - 3.6e-12 45.2 0.1 7.9e-11 40.8 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFX06506.1 - 1.3e-10 41.4 0.0 3.6e-08 33.5 0.0 2.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX06506.1 - 3.6e-07 30.0 0.0 9.6e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX06506.1 - 9.2e-06 24.8 0.1 0.00024 20.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.14 EFX06506.1 - 0.01 14.9 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.19 EFX06506.1 - 0.014 14.3 0.0 0.12 11.2 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EFX06506.1 - 0.035 13.8 2.5 0.6 9.8 0.3 3.4 3 1 0 3 3 3 0 FAD-NAD(P)-binding Pkinase PF00069.20 EFX06507.1 - 2.9e-25 88.9 0.0 4.6e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EFX06507.1 - 2.3e-14 53.1 0.0 3.4e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HET PF06985.6 EFX06507.1 - 0.0011 19.1 0.0 0.0029 17.7 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) His_Phos_2 PF00328.17 EFX06508.1 - 9e-09 35.1 0.7 5.6e-08 32.5 0.5 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF3246 PF11596.3 EFX06508.1 - 0.61 9.3 14.7 0.99 8.6 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) LIM_bind PF01803.11 EFX06510.1 - 1.2e-59 201.3 0.0 1.2e-59 201.3 0.0 4.3 3 1 1 4 4 4 1 LIM-domain binding protein Plasmodium_HRP PF05403.6 EFX06510.1 - 0.29 10.6 42.7 0.46 10.0 29.6 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) HET PF06985.6 EFX06511.1 - 2.3e-30 105.5 2.1 2.3e-30 105.5 1.4 2.0 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) PRKCSH PF07915.8 EFX06512.1 - 2.3e-19 69.9 1.1 5.6e-19 68.7 0.8 1.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.5 EFX06512.1 - 0.042 13.0 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 GST_N_3 PF13417.1 EFX06513.1 - 1.5e-05 25.1 0.0 3.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PPR_2 PF13041.1 EFX06514.1 - 1.6e-15 56.7 0.0 1.7e-06 27.8 0.0 4.4 3 1 1 4 4 4 4 PPR repeat family PPR_3 PF13812.1 EFX06514.1 - 2.4e-14 52.3 7.4 0.00072 19.6 0.0 6.6 8 0 0 8 8 8 3 Pentatricopeptide repeat domain PPR PF01535.15 EFX06514.1 - 4.2e-12 45.1 1.0 7.2e-05 22.4 0.0 4.8 5 0 0 5 5 5 2 PPR repeat PPR_1 PF12854.2 EFX06514.1 - 1.2e-05 24.6 1.5 1.5 8.4 0.1 4.4 4 0 0 4 4 4 2 PPR repeat LsmAD PF06741.8 EFX06516.1 - 2e-21 75.8 1.2 4.8e-21 74.6 0.8 1.7 1 0 0 1 1 1 1 LsmAD domain CVNH PF08881.5 EFX06518.1 - 4.8e-31 107.0 0.5 7.1e-31 106.5 0.0 1.5 2 0 0 2 2 2 1 CVNH domain LysM PF01476.15 EFX06518.1 - 1.8e-11 43.7 0.0 3.1e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.10 EFX06518.1 - 6e-08 32.2 14.0 6e-08 32.2 9.7 3.0 4 0 0 4 4 4 1 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 EFX06518.1 - 2.8e-05 23.7 6.4 6.5e-05 22.5 4.5 1.6 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain Merozoite_SPAM PF07133.6 EFX06518.1 - 0.97 9.3 10.1 1.6 8.5 7.0 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DDRGK PF09756.4 EFX06518.1 - 1.4 8.3 9.7 44 3.4 7.2 2.1 2 0 0 2 2 2 0 DDRGK domain U79_P34 PF03064.11 EFX06518.1 - 8.8 5.7 14.4 0.04 13.4 3.4 1.9 3 0 0 3 3 3 0 HSV U79 / HCMV P34 VIT1 PF01988.14 EFX06521.1 - 2.2e-71 239.7 1.9 2.5e-71 239.5 1.3 1.1 1 0 0 1 1 1 1 VIT family 7TMR-DISM_7TM PF07695.6 EFX06521.1 - 0.013 15.1 3.2 0.023 14.3 2.2 1.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling CcmB PF03379.8 EFX06521.1 - 0.02 14.0 2.8 0.03 13.5 1.9 1.2 1 0 0 1 1 1 0 CcmB protein NB PF04159.8 EFX06521.1 - 0.097 12.4 0.8 0.43 10.3 0.4 2.0 2 0 0 2 2 2 0 NB glycoprotein TBCA PF02970.11 EFX06521.1 - 0.1 12.6 3.7 0.16 12.0 2.6 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A SpoVA PF03862.8 EFX06521.1 - 0.18 11.9 5.5 0.35 10.9 3.8 1.5 1 0 0 1 1 1 0 SpoVA protein Sec6 PF06046.8 EFX06522.1 - 5.3e-151 503.5 0.0 7.7e-151 502.9 0.0 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.7 EFX06522.1 - 0.0017 17.2 3.5 0.0017 17.2 2.4 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF755 PF05501.6 EFX06522.1 - 0.096 12.7 0.5 0.19 11.8 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Hemerythrin PF01814.18 EFX06522.1 - 0.52 10.4 15.1 0.51 10.5 0.2 4.9 5 1 1 6 6 6 0 Hemerythrin HHE cation binding domain DASH_Dam1 PF08653.5 EFX06522.1 - 0.95 9.2 7.0 0.83 9.4 0.2 4.0 4 1 2 6 6 6 0 DASH complex subunit Dam1 XPA_C PF05181.7 EFX06523.1 - 2.2e-30 103.9 3.5 5.6e-30 102.6 2.4 1.7 1 0 0 1 1 1 1 XPA protein C-terminus ArfGap PF01412.13 EFX06523.1 - 0.019 14.7 3.0 0.019 14.7 2.1 2.3 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf zf-C3HC4_3 PF13920.1 EFX06523.1 - 1.2 8.8 9.8 1.3 8.7 4.8 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) XPA_N PF01286.13 EFX06523.1 - 2 8.1 11.3 0.15 11.7 4.3 1.7 2 0 0 2 2 2 0 XPA protein N-terminal DNA_binding_1 PF01035.15 EFX06524.1 - 4.4e-20 71.2 0.1 2.8e-19 68.6 0.1 1.9 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF4224 PF13986.1 EFX06524.1 - 0.07 12.6 0.0 0.32 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) Steroid_dh PF02544.11 EFX06525.1 - 3.4e-21 75.5 0.9 9.8e-21 74.0 0.1 2.1 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.8 EFX06525.1 - 0.0035 17.4 0.2 0.016 15.3 0.0 2.1 3 0 0 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.7 EFX06525.1 - 0.015 14.6 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Asparaginase_2 PF01112.13 EFX06526.1 - 1.5e-31 109.2 10.1 1.3e-18 66.8 0.0 2.2 1 1 1 2 2 2 2 Asparaginase Trp_syntA PF00290.15 EFX06527.1 - 3.6e-93 310.8 0.3 3.2e-92 307.7 0.0 2.0 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.20 EFX06527.1 - 4e-43 147.8 0.9 4e-43 147.8 0.6 2.3 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme PcrB PF01884.12 EFX06527.1 - 0.11 11.7 0.1 0.89 8.7 0.1 2.1 2 0 0 2 2 2 0 PcrB family HET PF06985.6 EFX06528.1 - 7.7e-06 26.1 1.2 0.00064 19.8 0.0 2.9 3 0 0 3 3 3 2 Heterokaryon incompatibility protein (HET) Ferric_reduct PF01794.14 EFX06529.1 - 5.7e-24 84.5 9.1 5.7e-24 84.5 6.3 2.1 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EFX06529.1 - 2e-11 43.6 0.0 3.6e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EFX06529.1 - 1.5e-10 41.2 0.0 2e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EFX06529.1 - 0.01 16.4 0.0 0.042 14.4 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Na_Ca_ex PF01699.19 EFX06530.1 - 1e-30 106.1 26.0 1e-16 60.8 4.7 3.3 4 0 0 4 4 4 2 Sodium/calcium exchanger protein DUF307 PF03733.8 EFX06530.1 - 8.9e-14 51.6 11.4 8.9e-14 51.6 7.9 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF307) zf-CSL PF05207.8 EFX06532.1 - 2.1e-21 75.1 0.2 2.1e-21 75.1 0.1 2.0 2 0 0 2 2 2 1 CSL zinc finger Avl9 PF09794.4 EFX06532.1 - 0.073 11.5 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 Transport protein Avl9 Gon7 PF08738.5 EFX06533.1 - 1.8e-10 40.7 0.7 6.2e-09 35.7 0.1 2.0 1 1 1 2 2 2 2 Gon7 family DUF3138 PF11336.3 EFX06533.1 - 0.03 12.5 3.5 0.033 12.3 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF1542 PF07564.6 EFX06533.1 - 0.69 9.9 3.9 1.1 9.3 2.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Kinesin PF00225.18 EFX06534.1 - 1.2e-87 293.7 0.2 4.8e-87 291.7 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain IncA PF04156.9 EFX06534.1 - 0.0047 16.5 8.5 0.0047 16.5 5.9 11.7 5 2 3 8 8 8 2 IncA protein Fib_alpha PF08702.5 EFX06534.1 - 5.1 7.2 78.5 0.59 10.2 1.1 10.2 5 2 5 11 11 11 0 Fibrinogen alpha/beta chain family LicD PF04991.8 EFX06535.1 - 2.3e-35 122.5 5.5 8e-34 117.5 3.8 2.1 1 1 0 1 1 1 1 LicD family DnaJ PF00226.26 EFX06536.1 - 1.1e-20 73.1 0.1 1.8e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.6 EFX06536.1 - 8.3e-18 64.5 0.0 1.4e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) Aldo_ket_red PF00248.16 EFX06537.1 - 2e-47 161.3 0.0 2.6e-47 160.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family SPO22 PF08631.5 EFX06538.1 - 0.027 13.5 0.0 0.041 12.9 0.0 1.1 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Metallophos PF00149.23 EFX06540.1 - 3.9e-37 127.6 0.0 3.6e-32 111.4 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase TMEM51 PF15345.1 EFX06541.1 - 0.0054 16.4 0.0 0.0082 15.8 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 Herpes_gE PF02480.11 EFX06541.1 - 0.01 14.1 0.0 0.02 13.1 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF1191 PF06697.7 EFX06541.1 - 0.014 14.2 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) DUF2561 PF10812.3 EFX06541.1 - 0.75 9.3 6.4 1.6 8.2 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) PAT1 PF09770.4 EFX06541.1 - 1.3 7.1 13.1 1.8 6.7 9.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 adh_short PF00106.20 EFX06543.1 - 8.1e-28 97.4 8.9 1.4e-27 96.6 6.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX06543.1 - 5.7e-26 91.7 0.5 7.3e-26 91.4 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX06543.1 - 1.8e-08 34.2 5.7 1.8e-08 34.2 3.9 1.8 2 1 0 2 2 2 1 KR domain Epimerase PF01370.16 EFX06543.1 - 4.1e-05 23.1 0.4 0.00013 21.4 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Aldo_ket_red PF00248.16 EFX06544.1 - 2.9e-74 249.4 0.0 3.2e-74 249.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_L28 PF00830.14 EFX06545.1 - 1.6e-16 59.8 1.1 2.3e-16 59.3 0.7 1.2 1 0 0 1 1 1 1 Ribosomal L28 family Pro-kuma_activ PF09286.6 EFX06546.1 - 4.4e-28 98.1 0.3 3.8e-26 91.8 0.1 2.5 2 1 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EFX06546.1 - 5.3e-06 25.7 0.2 1.2e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Subtilase family KorB PF08535.5 EFX06546.1 - 0.13 12.4 0.1 0.52 10.4 0.0 2.0 2 1 0 2 2 2 0 KorB domain DUF2072 PF09845.4 EFX06547.1 - 0.012 15.4 0.8 0.012 15.4 0.5 2.2 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) CobT PF06213.7 EFX06547.1 - 0.058 12.5 8.6 0.091 11.8 6.0 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Spore_SspJ PF09575.5 EFX06547.1 - 0.24 11.6 5.1 0.49 10.6 3.6 1.5 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) Glyco_hydro_16 PF00722.16 EFX06548.1 - 3.6e-40 137.2 5.0 3.6e-40 137.2 3.5 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 DUF515 PF04415.7 EFX06548.1 - 8.9 4.4 14.4 13 3.9 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) SSP160 PF06933.6 EFX06548.1 - 9.4 4.0 26.7 16 3.3 18.5 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Alg14 PF08660.6 EFX06549.1 - 2e-40 138.5 0.2 4.3e-40 137.4 0.0 1.6 2 0 0 2 2 2 1 Oligosaccharide biosynthesis protein Alg14 like Kp4 PF09044.5 EFX06550.1 - 8.5e-28 96.7 3.6 1.2e-27 96.2 2.5 1.1 1 0 0 1 1 1 1 Kp4 MU117 PF15474.1 EFX06550.1 - 0.00078 19.8 1.5 0.001 19.4 1.0 1.2 1 0 0 1 1 1 1 Meiotically up-regulated gene family SPOR PF05036.8 EFX06550.1 - 0.083 13.0 0.0 2.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Sporulation related domain Ank_2 PF12796.2 EFX06551.1 - 9.4e-45 150.8 22.4 3.3e-13 49.7 1.1 4.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EFX06551.1 - 1.7e-36 122.2 28.0 3.7e-08 32.7 0.1 8.2 8 1 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.1 EFX06551.1 - 3.8e-31 104.0 7.9 1.7e-05 24.6 0.0 7.9 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.1 EFX06551.1 - 3.9e-30 103.6 21.6 4.5e-07 30.2 0.1 6.7 3 3 4 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 EFX06551.1 - 7.5e-20 70.5 31.9 1.8e-06 28.0 0.5 6.7 4 2 3 7 7 7 5 Ankyrin repeats (many copies) FA PF08736.6 EFX06551.1 - 0.02 14.6 0.9 3.8 7.3 0.0 3.2 3 0 0 3 3 3 0 FERM adjacent (FA) DUF1843 PF08898.5 EFX06551.1 - 0.086 12.8 0.2 0.086 12.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) DUF325 PF03804.8 EFX06551.1 - 0.15 11.7 0.2 0.95 9.2 0.0 2.2 2 0 0 2 2 2 0 Viral domain of unknown function Toxin_58 PF15536.1 EFX06551.1 - 0.21 11.4 1.1 20 5.0 0.0 3.0 3 1 1 4 4 4 0 Putative toxin 58 Reductase_C PF14759.1 EFX06551.1 - 0.28 11.4 3.3 14 6.0 0.0 3.9 4 0 0 4 4 4 0 Reductase C-terminal DPBB_1 PF03330.13 EFX06552.1 - 6.3e-10 38.9 2.9 6.6e-10 38.8 0.1 2.6 2 0 0 2 2 2 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 EFX06552.1 - 4.8e-06 26.2 0.1 1.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Barwin family BNR PF02012.15 EFX06552.1 - 0.051 13.4 1.0 0.17 11.8 0.7 2.0 1 0 0 1 1 1 0 BNR/Asp-box repeat Mo-co_dimer PF03404.11 EFX06552.1 - 0.096 12.3 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain tRNA_edit PF04073.10 EFX06552.1 - 0.11 12.2 1.1 0.21 11.4 0.8 1.5 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain LmjF365940-deam PF14421.1 EFX06553.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases MFS_1 PF07690.11 EFX06554.1 - 2e-38 132.0 47.7 2e-38 132.0 33.0 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EFX06554.1 - 1.3e-15 56.6 23.0 2.5e-15 55.7 15.9 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Strabismus PF06638.6 EFX06554.1 - 0.94 7.7 2.6 1.4 7.1 1.8 1.2 1 0 0 1 1 1 0 Strabismus protein UNC45-central PF11701.3 EFX06555.1 - 6.3e-47 159.1 0.0 1.4e-46 158.0 0.0 1.6 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central Aminotran_1_2 PF00155.16 EFX06556.1 - 2.3e-87 293.3 0.0 2.6e-87 293.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II zf-C2H2_4 PF13894.1 EFX06557.1 - 3.2e-05 23.9 24.3 0.0072 16.5 0.9 5.1 4 1 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EFX06557.1 - 0.00027 21.0 28.1 0.0017 18.5 0.7 4.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EFX06557.1 - 0.0017 18.5 0.4 0.0017 18.5 0.3 4.0 5 1 0 5 5 5 1 Zinc-finger double domain zf-CHCC PF10276.4 EFX06557.1 - 0.041 13.7 9.4 0.41 10.5 0.5 2.8 3 0 0 3 3 3 0 Zinc-finger domain zf-C2HC_2 PF13913.1 EFX06557.1 - 0.32 10.7 5.3 3.7 7.3 0.3 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type She9_MDM33 PF05546.6 EFX06557.1 - 1.3 8.4 3.9 0.64 9.5 0.1 2.0 2 0 0 2 2 2 0 She9 / Mdm33 family PyrI_C PF02748.10 EFX06557.1 - 4.9 6.6 7.9 4.9 6.6 1.9 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain RhoGAP PF00620.22 EFX06558.1 - 4.2e-12 45.9 0.0 7.2e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Methyltransf_23 PF13489.1 EFX06559.1 - 5.4e-17 61.9 0.0 9.3e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EFX06559.1 - 5e-10 39.7 0.0 1e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EFX06559.1 - 2.4e-08 34.3 0.0 1.1e-07 32.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EFX06559.1 - 3.5e-08 34.0 0.0 6.8e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EFX06559.1 - 1.4e-05 24.7 0.0 0.00048 19.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EFX06559.1 - 0.00015 21.0 0.0 0.00061 18.9 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EFX06559.1 - 0.00025 21.3 0.0 0.00055 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EFX06559.1 - 0.0023 16.9 0.0 0.007 15.4 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 EFX06559.1 - 0.0062 15.9 0.0 0.032 13.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EFX06559.1 - 0.0074 16.3 0.0 0.077 13.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EFX06559.1 - 0.012 15.6 0.0 0.03 14.2 0.0 1.7 2 0 0 2 2 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.4 EFX06559.1 - 0.059 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase DUF4235 PF14019.1 EFX06560.1 - 0.046 13.5 5.7 1 9.2 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4235) Se-cys_synth_N PF12390.3 EFX06560.1 - 0.046 13.8 7.4 0.038 14.0 3.1 2.6 2 0 0 2 2 2 0 Selenocysteine synthase N terminal 60KD_IMP PF02096.15 EFX06561.1 - 1.8e-11 44.1 0.0 3.2e-11 43.2 0.0 1.4 1 1 0 1 1 1 1 60Kd inner membrane protein DUF2435 PF10363.4 EFX06563.1 - 2.2e-14 53.1 0.3 1.4e-12 47.3 0.0 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 EFX06563.1 - 1.2e-11 43.8 0.3 3.3e-11 42.3 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) HEAT_2 PF13646.1 EFX06563.1 - 0.81 10.0 13.8 3.1 8.1 4.0 4.1 3 1 0 3 3 3 0 HEAT repeats Tcf25 PF04910.9 EFX06564.1 - 6e-59 199.7 0.0 8.3e-59 199.3 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Guanylate_kin PF00625.16 EFX06565.1 - 1.8e-58 196.9 0.0 2.1e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 EFX06565.1 - 1.5e-05 24.8 0.0 3.5e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EFX06565.1 - 6.6e-05 22.1 0.0 0.00023 20.3 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 EFX06565.1 - 7.6e-05 22.8 0.0 0.0012 18.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX06565.1 - 0.00026 21.2 0.0 0.0013 19.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EFX06565.1 - 0.001 19.8 0.2 0.0022 18.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 EFX06565.1 - 0.0028 17.2 0.1 0.27 10.7 0.0 2.2 1 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EFX06565.1 - 0.0037 17.2 0.0 0.0039 17.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.18 EFX06565.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.1 EFX06565.1 - 0.027 14.3 0.0 0.044 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EFX06565.1 - 0.032 14.1 0.0 0.047 13.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFX06565.1 - 0.034 13.8 0.3 0.27 10.9 0.2 2.0 1 1 0 1 1 1 0 Archaeal ATPase Phage_XkdX PF09693.5 EFX06565.1 - 0.041 13.4 0.1 0.079 12.4 0.1 1.4 1 0 0 1 1 1 0 Phage uncharacterised protein (Phage_XkdX) adh_short PF00106.20 EFX06566.1 - 9.1e-34 116.7 0.9 1.2e-33 116.3 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX06566.1 - 4.6e-27 95.3 0.0 6.3e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX06566.1 - 8.4e-16 58.1 0.3 1.2e-15 57.6 0.2 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EFX06566.1 - 0.003 17.2 0.5 0.0059 16.2 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DDE_Tnp_1 PF01609.16 EFX06566.1 - 0.036 13.5 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain UDPG_MGDP_dh_N PF03721.9 EFX06566.1 - 0.059 12.7 0.1 0.097 12.0 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CFEM PF05730.6 EFX06568.1 - 2.9e-13 49.4 7.8 5.4e-13 48.5 5.4 1.5 1 0 0 1 1 1 1 CFEM domain Ribosomal_S7 PF00177.16 EFX06569.1 - 2e-40 137.7 0.9 2.8e-40 137.2 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Rav1p_C PF12234.3 EFX06570.1 - 1.7e-261 868.9 0.0 2.2e-261 868.5 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal WD40 PF00400.27 EFX06570.1 - 0.0014 18.4 3.5 8.1 6.4 0.3 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat G0-G1_switch_2 PF15103.1 EFX06570.1 - 0.17 12.0 0.0 2.1 8.6 0.0 2.7 3 0 0 3 3 3 0 G0/G1 switch protein 2 NmrA PF05368.8 EFX06571.1 - 2e-07 30.5 0.0 2.3e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EFX06571.1 - 0.05 13.6 0.0 0.23 11.4 0.0 2.2 1 1 1 2 2 2 0 NADH(P)-binding NB-ARC PF00931.17 EFX06572.1 - 1.6e-14 53.4 0.0 3.8e-14 52.2 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain TPR_12 PF13424.1 EFX06572.1 - 5.6e-08 32.6 3.1 0.00075 19.3 0.1 4.5 3 1 1 5 5 5 2 Tetratricopeptide repeat AAA_16 PF13191.1 EFX06572.1 - 0.00017 21.5 0.0 0.00056 19.9 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain Arch_ATPase PF01637.13 EFX06572.1 - 0.00031 20.4 0.0 0.0015 18.2 0.0 2.0 1 1 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 EFX06572.1 - 0.00041 20.4 0.0 0.0009 19.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain TPR_7 PF13176.1 EFX06572.1 - 0.0005 19.6 0.4 10 6.1 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 EFX06572.1 - 0.0013 18.6 0.8 8.4 6.4 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 EFX06572.1 - 0.014 15.7 0.1 0.83 10.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Chromo PF00385.19 EFX06573.1 - 6.7e-09 35.3 0.7 1.5e-08 34.1 0.5 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain D-aminoacyl_C PF07908.7 EFX06574.1 - 2.9e-14 52.1 0.1 20 4.5 0.0 11.4 12 0 0 12 12 12 3 D-aminoacylase, C-terminal region Tnp_P_element_C PF12596.3 EFX06574.1 - 2.4e-05 24.5 29.0 62 3.9 0.3 11.5 1 1 10 11 11 11 0 87kDa Transposase Alpha_E2_glycop PF00943.14 EFX06574.1 - 0.014 14.0 27.6 14 4.1 0.1 9.7 1 1 11 12 12 12 0 Alphavirus E2 glycoprotein HycA_repressor PF11046.3 EFX06574.1 - 0.29 11.0 6.9 1e+02 2.8 0.0 6.0 1 1 9 10 10 10 0 Transcriptional repressor of hyc and hyp operons DEAD PF00270.24 EFX06576.1 - 1.8e-33 115.4 0.0 8.6e-16 57.8 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX06576.1 - 1.1e-21 76.4 0.2 2.8e-21 75.1 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX06576.1 - 8.6e-05 22.4 4.4 0.00018 21.4 0.0 3.2 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Tcp11 PF05794.8 EFX06577.1 - 2.8e-35 121.9 0.4 4.8e-31 107.9 0.0 2.5 3 0 0 3 3 3 2 T-complex protein 11 PBP1_TM PF14812.1 EFX06578.1 - 0.0021 18.3 0.7 0.0048 17.1 0.5 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal TT_ORF2 PF02957.10 EFX06578.1 - 0.07 13.8 0.7 0.17 12.6 0.1 1.9 2 0 0 2 2 2 0 TT viral ORF2 DEAD PF00270.24 EFX06579.1 - 3.8e-39 133.8 0.2 3e-38 130.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EFX06579.1 - 2.2e-18 65.8 0.0 5.7e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EFX06579.1 - 5.4e-05 23.0 0.0 0.00035 20.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EFX06579.1 - 0.00047 19.0 0.0 0.00073 18.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_30 PF13604.1 EFX06579.1 - 0.0016 18.0 0.1 0.0037 16.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain Fungal_trans PF04082.13 EFX06580.1 - 6.7e-28 97.2 0.0 1.4e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EFX06580.1 - 2.1e-07 30.6 13.5 4.9e-07 29.5 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NYD-SP28_assoc PF14775.1 EFX06580.1 - 0.13 12.0 2.0 0.25 11.0 1.4 1.4 1 0 0 1 1 1 0 Sperm tail C-terminal domain Ribosomal_L37ae PF01780.14 EFX06580.1 - 0.48 10.3 6.4 1.4 8.7 4.4 1.8 1 0 0 1 1 1 0 Ribosomal L37ae protein family Zn_clus PF00172.13 EFX06581.1 - 0.0028 17.5 8.1 0.012 15.4 5.6 2.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CHCC PF10276.4 EFX06581.1 - 0.005 16.6 2.4 0.24 11.2 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger domain zf-C2H2_jaz PF12171.3 EFX06581.1 - 0.0069 16.4 1.0 0.079 13.1 0.1 3.0 2 1 1 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EFX06581.1 - 0.02 15.1 0.4 0.02 15.1 0.3 5.6 4 1 1 5 5 5 0 Zinc finger, C2H2 type DUF3371 PF11851.3 EFX06581.1 - 5.4 7.7 19.2 0.17 12.5 1.0 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3371) adh_short PF00106.20 EFX06582.1 - 4.9e-23 81.8 4.9 9.9e-22 77.6 3.4 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EFX06582.1 - 1.9e-17 63.8 0.0 2.8e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EFX06582.1 - 3.9e-06 26.6 2.0 2e-05 24.3 1.1 2.1 1 1 1 2 2 2 1 KR domain MFS_1 PF07690.11 EFX06583.1 - 1.8e-36 125.6 41.8 6.2e-36 123.8 29.0 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EFX06583.1 - 2.3e-10 39.6 14.3 2.3e-10 39.6 9.9 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter DnaJ PF00226.26 EFX06584.1 - 1.2e-05 24.9 0.0 2.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF1903 PF08991.5 EFX06585.1 - 0.058 13.5 0.1 0.083 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) TRI9 PF08195.6 EFX06585.1 - 0.3 10.7 6.2 0.41 10.3 4.3 1.2 1 0 0 1 1 1 0 TRI9 protein Fungal_trans PF04082.13 EFX06586.1 - 8.4e-07 28.1 0.2 1.4e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2781 PF10914.3 EFX06586.1 - 0.19 11.5 2.8 1.3 8.7 1.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2781) PAPA-1 PF04795.7 EFX06587.1 - 7.3e-24 84.2 1.9 7.3e-24 84.2 1.3 2.5 3 0 0 3 3 3 1 PAPA-1-like conserved region GLTSCR1 PF15249.1 EFX06587.1 - 0.65 10.1 0.0 0.65 10.1 0.0 2.4 2 1 0 2 2 2 0 Glioma tumor suppressor candidate region GMC_oxred_N PF00732.14 EFX06588.1 - 6.9e-26 91.0 0.0 1e-23 83.9 0.1 3.0 2 1 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX06588.1 - 1.5e-24 86.9 0.0 2.5e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.9 EFX06588.1 - 0.00012 21.9 0.0 0.0006 19.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EFX06588.1 - 0.00021 21.4 0.0 0.26 11.3 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX06588.1 - 0.0013 17.7 0.7 0.45 9.3 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EFX06588.1 - 0.0093 15.9 0.5 0.041 13.8 0.4 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EFX06588.1 - 0.016 14.0 0.2 0.15 10.8 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.7 EFX06588.1 - 0.022 13.6 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HHH PF00633.18 EFX06588.1 - 0.026 14.2 0.1 3.2 7.6 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif HI0933_like PF03486.9 EFX06588.1 - 0.14 10.5 0.1 0.21 10.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.11 EFX06589.1 - 2.5e-31 108.6 32.5 2.5e-31 108.6 22.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily ESSS PF10183.4 EFX06589.1 - 0.42 11.0 2.7 0.63 10.4 0.6 2.2 2 1 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Actin PF00022.14 EFX06591.1 - 9.1e-88 294.3 0.0 2e-87 293.1 0.0 1.5 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EFX06591.1 - 0.027 13.0 0.0 1.6 7.2 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein AcetylCoA_hydro PF02550.10 EFX06592.1 - 5.7e-49 166.5 0.0 8.5e-49 165.9 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.1 EFX06592.1 - 8.2e-39 132.7 0.0 1.2e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain PRK PF00485.13 EFX06595.1 - 7e-05 22.4 0.0 0.0026 17.3 0.0 2.3 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.7 EFX06595.1 - 0.00024 20.7 0.1 0.00083 19.0 0.0 1.9 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.1 EFX06595.1 - 0.00038 21.2 0.0 0.00095 19.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EFX06595.1 - 0.0026 17.7 0.0 0.0058 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EFX06595.1 - 0.0028 17.9 0.0 0.024 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EFX06596.1 - 4.4e-16 59.2 0.0 8.3e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 EFX06596.1 - 1.3e-14 53.8 0.0 3.9e-14 52.3 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EFX06596.1 - 4.2e-13 49.2 0.0 1.3e-12 47.6 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 EFX06596.1 - 2.4e-08 33.1 0.0 8.5e-07 28.0 0.0 2.4 3 0 0 3 3 3 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 EFX06596.1 - 1e-07 32.1 0.2 4.4e-06 26.8 0.0 2.8 1 1 2 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EFX06596.1 - 5.2e-07 29.8 0.1 8.1e-06 25.9 0.0 2.5 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.1 EFX06596.1 - 1.1e-06 28.2 0.0 3.7e-06 26.6 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EFX06596.1 - 2.3e-06 27.3 0.0 4.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 EFX06596.1 - 3.5e-06 26.7 0.0 6.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EFX06596.1 - 3.7e-06 26.1 0.1 0.00014 21.0 0.0 2.4 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EFX06596.1 - 4.9e-06 26.4 0.0 2.9e-05 23.9 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 EFX06596.1 - 2.4e-05 24.0 0.1 0.00018 21.2 0.0 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.1 EFX06596.1 - 4.8e-05 23.0 0.0 0.00022 20.8 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.6 EFX06596.1 - 4.8e-05 22.9 0.0 0.00045 19.8 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 EFX06596.1 - 5.8e-05 22.1 0.0 9.1e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.8 EFX06596.1 - 6.1e-05 21.9 0.0 0.16 10.6 0.0 2.1 2 0 0 2 2 2 2 TIP49 C-terminus DNA_pol3_delta PF06144.8 EFX06596.1 - 0.00017 21.1 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.16 EFX06596.1 - 0.0042 16.2 0.1 0.071 12.2 0.0 2.5 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 EFX06596.1 - 0.005 16.3 0.1 2 7.7 0.0 2.4 1 1 1 2 2 2 1 AAA-like domain DUF2075 PF09848.4 EFX06596.1 - 0.0054 15.7 0.0 0.0083 15.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.24 EFX06596.1 - 0.0068 15.9 0.0 0.15 11.4 0.0 2.3 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_25 PF13481.1 EFX06596.1 - 0.0069 15.8 0.0 0.018 14.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EFX06596.1 - 0.0072 16.2 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 EFX06596.1 - 0.009 15.2 0.0 1.4 8.0 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein IstB_IS21 PF01695.12 EFX06596.1 - 0.013 14.9 0.0 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_17 PF13207.1 EFX06596.1 - 0.022 15.5 0.0 0.048 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EFX06596.1 - 0.041 13.5 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase RNA_pol_Rpc34 PF05158.7 EFX06596.1 - 0.057 12.6 0.0 0.1 11.7 0.0 1.3 1 1 0 1 1 1 0 RNA polymerase Rpc34 subunit AAA_18 PF13238.1 EFX06596.1 - 0.058 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 EFX06596.1 - 0.064 13.0 0.0 0.17 11.7 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.13 EFX06596.1 - 0.069 12.6 0.0 0.3 10.5 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 EFX06596.1 - 0.071 13.2 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SNF2_N PF00176.18 EFX06596.1 - 0.071 11.8 0.1 1.6 7.4 0.0 2.4 3 0 0 3 3 3 0 SNF2 family N-terminal domain ROKNT PF08067.6 EFX06596.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 ROKNT (NUC014) domain Pyr_redox_3 PF13738.1 EFX06597.1 - 2.9e-20 73.2 0.1 4.9e-20 72.4 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX06597.1 - 9.2e-12 43.9 0.1 8.9e-11 40.6 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFX06597.1 - 1.2e-09 37.6 0.0 3e-08 32.9 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFX06597.1 - 1.4e-09 37.8 0.0 6e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EFX06597.1 - 3e-06 27.2 0.0 7.5e-06 25.9 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EFX06597.1 - 1.8e-05 23.8 0.0 0.031 13.1 0.0 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase Mqo PF06039.10 EFX06597.1 - 0.00011 20.5 0.1 0.1 10.7 0.0 2.4 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) NAD_binding_9 PF13454.1 EFX06597.1 - 0.00074 19.3 1.6 0.11 12.2 0.1 3.7 3 1 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.12 EFX06597.1 - 0.11 11.5 0.2 0.43 9.6 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.22 EFX06597.1 - 0.52 10.7 1.8 12 6.3 0.1 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.17 EFX06598.1 - 9.9e-16 57.1 0.0 8.1e-08 31.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EFX06598.1 - 2.7e-12 46.4 0.0 8e-11 41.7 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EFX06598.1 - 4e-08 32.9 0.0 5.4e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.17 EFX06599.1 - 2.1e-63 212.5 0.2 2.4e-63 212.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EFX06599.1 - 1.9e-21 76.7 0.1 2.7e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EFX06599.1 - 3.8e-13 49.0 0.1 5e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EFX06599.1 - 3e-08 33.6 0.1 4.8e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EFX06599.1 - 4.6e-05 22.9 0.1 0.00015 21.2 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EFX06599.1 - 9.7e-05 21.6 0.1 0.00016 20.8 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 EFX06599.1 - 0.00012 22.2 0.1 0.00032 20.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EFX06599.1 - 0.0015 18.4 0.1 0.0034 17.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 EFX06599.1 - 0.002 17.2 0.1 0.0022 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EFX06599.1 - 0.0026 16.9 0.1 0.0063 15.7 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 SpoIIID PF12116.3 EFX06599.1 - 0.0073 16.2 0.1 0.095 12.6 0.0 2.1 2 0 0 2 2 2 1 Stage III sporulation protein D SRPRB PF09439.5 EFX06599.1 - 0.013 14.7 0.0 0.021 14.0 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 EFX06599.1 - 0.017 14.6 0.1 0.069 12.7 0.0 1.7 1 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EFX06599.1 - 0.018 15.3 0.1 0.025 14.8 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 EFX06599.1 - 0.023 14.6 0.3 0.045 13.7 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.13 EFX06599.1 - 0.089 12.0 0.1 0.22 10.7 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.1 EFX06599.1 - 0.097 12.2 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 EFX06599.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF953 PF06110.6 EFX06600.1 - 2.1e-15 56.2 0.0 2.6e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.15 EFX06600.1 - 0.0012 18.4 0.0 0.0017 18.0 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.1 EFX06600.1 - 0.017 14.7 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.1 EFX06600.1 - 0.063 13.3 0.0 5 7.3 0.0 2.2 1 1 1 2 2 2 0 Thioredoxin-like Aldo_ket_red PF00248.16 EFX06601.1 - 3.5e-71 239.3 0.0 4e-71 239.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1498 PF07385.7 EFX06601.1 - 0.11 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1498) Amidoligase_2 PF12224.3 EFX06603.1 - 1e-14 54.8 0.0 1.5e-09 37.8 0.0 2.2 1 1 0 2 2 2 2 Putative amidoligase enzyme B12D PF06522.6 EFX06604.1 - 3.2e-11 42.7 0.0 5.1e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit AIF-MLS PF14962.1 EFX06604.1 - 0.067 12.8 0.4 0.074 12.7 0.3 1.3 1 1 0 1 1 1 0 Mitochondria Localisation Sequence DSPc PF00782.15 EFX06605.1 - 8.9e-10 38.2 0.0 3.6e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Clathrin PF00637.15 EFX06606.1 - 2.1e-20 72.7 1.8 1.5e-19 70.0 0.2 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.3 EFX06606.1 - 3.6e-17 61.9 0.0 8.5e-17 60.7 0.0 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal HATPase_c_3 PF13589.1 EFX06606.1 - 4e-11 42.7 0.0 7.7e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-RING_5 PF14634.1 EFX06606.1 - 9.7e-05 22.0 0.6 0.00018 21.1 0.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain MutL_C PF08676.6 EFX06606.1 - 9.9e-05 21.9 0.1 0.00048 19.7 0.1 2.2 1 1 0 1 1 1 1 MutL C terminal dimerisation domain zf-RING_2 PF13639.1 EFX06606.1 - 0.001 18.8 1.7 0.0027 17.4 1.2 1.8 1 0 0 1 1 1 1 Ring finger domain HATPase_c PF02518.21 EFX06606.1 - 0.0062 16.2 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_11 PF13414.1 EFX06606.1 - 0.071 12.7 1.1 0.21 11.2 0.0 2.3 3 0 0 3 3 3 0 TPR repeat zf-C3HC4 PF00097.20 EFX06606.1 - 0.088 12.4 0.3 0.2 11.3 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EFX06606.1 - 0.1 12.7 0.6 0.23 11.5 0.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-Apc11 PF12861.2 EFX06606.1 - 0.12 12.2 0.9 0.32 10.8 0.6 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 EFX06606.1 - 0.31 11.0 1.6 0.76 9.8 1.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_19 PF14559.1 EFX06606.1 - 1.1 9.6 4.5 27 5.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 EFX06606.1 - 6.7 6.9 8.6 29 4.8 0.8 3.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.27 EFX06608.1 - 2.1e-16 59.0 7.8 0.00032 20.4 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat Ribosomal_L32p PF01783.18 EFX06608.1 - 2.5e-09 37.1 9.4 2.7e-09 37.0 5.5 1.8 1 1 0 1 1 1 1 Ribosomal L32p protein family Nup160 PF11715.3 EFX06608.1 - 1.8e-05 23.1 0.1 0.0013 16.9 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 EFX06608.1 - 0.00016 20.1 0.0 0.00055 18.3 0.0 1.6 1 1 0 1 1 1 1 Cytochrome D1 heme domain Nbas_N PF15492.1 EFX06608.1 - 0.055 12.5 0.4 0.35 9.9 0.0 2.4 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Hira PF07569.6 EFX06608.1 - 0.17 11.0 0.0 17 4.5 0.0 2.6 3 0 0 3 3 3 0 TUP1-like enhancer of split VID27 PF08553.5 EFX06608.1 - 0.36 8.9 0.0 0.52 8.4 0.0 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein AAA PF00004.24 EFX06609.1 - 9e-35 119.7 0.0 3e-34 118.0 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EFX06609.1 - 1.6e-09 38.0 0.5 2e-06 27.9 0.0 3.2 3 2 1 4 4 3 1 AAA ATPase domain AAA_22 PF13401.1 EFX06609.1 - 1.2e-06 28.7 0.3 0.00088 19.4 0.0 3.0 3 1 1 4 4 2 1 AAA domain AAA_14 PF13173.1 EFX06609.1 - 1.2e-05 25.1 0.0 3.1e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EFX06609.1 - 2.4e-05 23.3 0.0 3.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 EFX06609.1 - 0.00013 21.7 0.0 0.027 14.1 0.0 2.2 1 1 1 2 2 2 1 Archaeal ATPase AAA_5 PF07728.9 EFX06609.1 - 0.00014 21.5 0.1 0.00069 19.3 0.1 2.3 3 1 0 3 3 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EFX06609.1 - 0.00018 21.4 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EFX06609.1 - 0.00025 20.7 0.1 0.0013 18.4 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain RNA_helicase PF00910.17 EFX06609.1 - 0.00029 20.9 0.0 0.00067 19.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase RuvB_N PF05496.7 EFX06609.1 - 0.00042 19.4 0.0 0.00071 18.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 EFX06609.1 - 0.00047 19.7 0.0 0.00075 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EFX06609.1 - 0.00048 19.5 0.1 0.13 11.6 0.0 3.1 2 1 0 3 3 3 1 AAA domain AAA_17 PF13207.1 EFX06609.1 - 0.00068 20.4 0.1 0.0017 19.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EFX06609.1 - 0.0017 17.8 0.0 0.0048 16.3 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_28 PF13521.1 EFX06609.1 - 0.0017 18.3 0.0 0.007 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EFX06609.1 - 0.0042 17.3 0.0 0.008 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EFX06609.1 - 0.0048 16.0 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.1 EFX06609.1 - 0.018 14.6 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EFX06609.1 - 0.021 14.2 0.0 0.34 10.3 0.0 2.4 1 1 1 2 2 2 0 AAA-like domain cobW PF02492.14 EFX06609.1 - 0.022 14.2 0.0 0.041 13.3 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 EFX06609.1 - 0.03 13.9 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_2 PF07724.9 EFX06609.1 - 0.034 14.0 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.1 EFX06609.1 - 0.035 14.1 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Miro PF08477.8 EFX06609.1 - 0.05 14.1 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein UPF0079 PF02367.12 EFX06609.1 - 0.051 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 EFX06609.1 - 0.052 13.1 0.1 0.13 11.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain Bac_DnaA PF00308.13 EFX06609.1 - 0.08 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein Zot PF05707.7 EFX06609.1 - 0.084 12.3 0.1 0.84 9.0 0.1 2.1 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_3 PF07726.6 EFX06609.1 - 0.084 12.4 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 EFX06609.1 - 0.091 11.9 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.18 EFX06609.1 - 0.093 12.6 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF853 PF05872.7 EFX06609.1 - 0.13 10.6 0.0 8 4.6 0.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) DUF258 PF03193.11 EFX06609.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Parvo_NS1 PF01057.12 EFX06609.1 - 0.17 10.7 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DIOX_N PF14226.1 EFX06610.1 - 2e-23 83.1 0.3 2e-23 83.1 0.2 1.6 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EFX06610.1 - 5.8e-08 32.9 0.0 1.1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3045 PF11243.3 EFX06610.1 - 0.013 15.6 0.1 0.58 10.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3045) Tfb4 PF03850.9 EFX06611.1 - 6.9e-84 281.3 0.0 8.2e-84 281.1 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 ALS_ss_C PF10369.4 EFX06612.1 - 5.8e-19 67.5 0.0 1.2e-17 63.3 0.0 2.6 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.20 EFX06612.1 - 1.2e-12 47.0 0.1 2.3e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 EFX06612.1 - 6.1e-09 35.5 0.0 1.1e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 ACT domain Hist_deacetyl PF00850.14 EFX06614.1 - 3.4e-87 292.6 0.0 5.6e-87 291.9 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Brix PF04427.13 EFX06614.1 - 5e-40 137.2 0.0 8.2e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Brix domain Arb2 PF09757.4 EFX06614.1 - 3.7e-33 114.4 0.0 7.9e-33 113.3 0.0 1.6 1 0 0 1 1 1 1 Arb2 domain Asp PF00026.18 EFX06615.1 - 4.5e-62 210.1 0.0 5.5e-62 209.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 EFX06615.1 - 0.00031 20.3 0.1 0.0027 17.2 0.0 2.5 3 0 0 3 3 3 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 EFX06615.1 - 0.0037 17.2 0.0 0.09 12.7 0.1 2.9 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal Aldedh PF00171.17 EFX06616.1 - 5.4e-124 414.0 0.0 2.4e-62 210.7 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family GATase_2 PF00310.16 EFX06617.1 - 2.8e-23 82.2 0.1 1.4e-18 66.7 0.0 2.2 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EFX06617.1 - 8.2e-18 64.6 0.0 1.5e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EFX06617.1 - 9.6e-17 60.8 0.0 2.3e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 EFX06617.1 - 4e-09 36.2 0.2 9.1e-09 35.1 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 EFX06617.1 - 2e-06 26.7 0.0 3.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Aminotran_1_2 PF00155.16 EFX06618.1 - 2e-64 217.8 0.0 2.4e-64 217.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EFX06618.1 - 1.7e-06 27.3 0.0 5e-06 25.8 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EFX06618.1 - 0.00028 20.1 0.0 0.00039 19.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EFX06618.1 - 0.00075 17.8 0.0 0.0022 16.3 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EFX06618.1 - 0.033 12.9 0.0 0.13 10.9 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class-V IncA PF04156.9 EFX06619.1 - 1.8e-07 30.9 14.5 3.5e-07 30.0 10.0 1.5 1 0 0 1 1 1 1 IncA protein DUF869 PF05911.6 EFX06619.1 - 1.3e-06 27.0 15.2 1.3e-06 27.0 10.5 1.8 2 0 0 2 2 1 1 Plant protein of unknown function (DUF869) Reo_sigmaC PF04582.7 EFX06619.1 - 1e-05 24.8 1.3 2.2e-05 23.8 0.9 1.5 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Cortex-I_coil PF09304.5 EFX06619.1 - 0.00013 21.9 24.9 0.0068 16.4 4.9 3.2 1 1 2 3 3 3 1 Cortexillin I, coiled coil AAA_27 PF13514.1 EFX06619.1 - 0.00033 18.5 19.6 0.00048 17.9 13.6 1.1 1 0 0 1 1 1 1 AAA domain Tropomyosin_1 PF12718.2 EFX06619.1 - 0.00042 20.1 33.3 0.00042 20.1 23.1 2.1 2 1 0 2 2 2 1 Tropomyosin like DUF3584 PF12128.3 EFX06619.1 - 0.00049 17.5 21.2 0.00082 16.8 14.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) MAD PF05557.8 EFX06619.1 - 0.0018 16.4 18.1 0.0033 15.5 12.5 1.4 1 0 0 1 1 1 1 Mitotic checkpoint protein Tropomyosin PF00261.15 EFX06619.1 - 0.0036 16.4 29.8 0.0036 16.4 20.6 1.8 2 0 0 2 2 2 1 Tropomyosin DUF4164 PF13747.1 EFX06619.1 - 0.0037 17.3 27.5 0.0073 16.4 2.6 3.0 3 1 0 3 3 2 2 Domain of unknown function (DUF4164) DUF2730 PF10805.3 EFX06619.1 - 0.045 13.4 0.2 0.045 13.4 0.1 2.7 3 1 0 3 3 2 0 Protein of unknown function (DUF2730) Laminin_I PF06008.9 EFX06619.1 - 0.045 13.0 22.6 0.2 10.9 8.1 2.4 1 1 1 2 2 2 0 Laminin Domain I EzrA PF06160.7 EFX06619.1 - 0.076 11.1 16.5 0.11 10.6 11.4 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA AAA_32 PF13654.1 EFX06619.1 - 0.17 10.5 12.8 0.25 9.9 8.9 1.2 1 0 0 1 1 1 0 AAA domain Baculo_PEP_C PF04513.7 EFX06619.1 - 0.23 11.2 8.4 0.62 9.8 1.2 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.7 EFX06619.1 - 0.25 10.6 27.3 6.3 6.0 14.4 2.3 1 1 1 2 2 2 0 PspA/IM30 family PilJ PF13675.1 EFX06619.1 - 0.35 11.2 14.7 1.1 9.5 2.9 2.5 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term TBPIP PF07106.8 EFX06619.1 - 0.39 10.2 20.8 6.2 6.3 11.4 2.6 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) WD40_alt PF14077.1 EFX06619.1 - 0.46 10.1 3.9 3.1 7.5 0.1 2.9 3 0 0 3 3 3 0 Alternative WD40 repeat motif ApoO PF09769.4 EFX06619.1 - 0.53 9.9 5.2 20 4.8 0.6 2.9 1 1 1 2 2 2 0 Apolipoprotein O Mnd1 PF03962.10 EFX06619.1 - 0.54 9.9 26.6 0.1 12.2 15.4 2.0 2 1 0 2 2 1 0 Mnd1 family bZIP_2 PF07716.10 EFX06619.1 - 0.84 9.5 17.4 2.3 8.1 0.9 3.8 2 2 1 3 3 3 0 Basic region leucine zipper Prefoldin_2 PF01920.15 EFX06619.1 - 0.87 9.3 30.5 0.14 11.8 1.8 3.9 2 1 2 4 4 4 0 Prefoldin subunit Fib_alpha PF08702.5 EFX06619.1 - 0.96 9.5 18.4 0.5 10.4 9.4 2.5 2 1 0 2 2 1 0 Fibrinogen alpha/beta chain family FH2 PF02181.18 EFX06619.1 - 1 8.1 14.9 1.8 7.3 0.6 2.0 1 1 1 2 2 2 0 Formin Homology 2 Domain Laminin_II PF06009.7 EFX06619.1 - 1 9.0 20.3 0.021 14.5 6.1 2.8 2 1 1 3 3 2 0 Laminin Domain II YlqD PF11068.3 EFX06619.1 - 1.3 9.0 25.4 1.6 8.7 12.1 2.8 2 1 1 3 3 3 0 YlqD protein Vac_Fusion PF02346.11 EFX06619.1 - 1.5 8.3 5.9 6.1 6.3 0.5 2.8 1 1 2 3 3 3 0 Chordopoxvirus fusion protein ERM PF00769.14 EFX06619.1 - 1.6 8.2 34.7 0.1 12.1 16.1 2.6 2 1 1 3 3 3 0 Ezrin/radixin/moesin family FlaC_arch PF05377.6 EFX06619.1 - 1.7 8.5 12.3 3.2 7.7 1.3 3.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) APG6 PF04111.7 EFX06619.1 - 1.9 7.4 27.7 0.73 8.8 15.0 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 SecD-TM1 PF13721.1 EFX06619.1 - 2 8.7 4.0 4.4 7.6 2.8 1.6 1 0 0 1 1 1 0 SecD export protein N-terminal TM region FUSC PF04632.7 EFX06619.1 - 2 6.7 3.7 3.3 6.0 2.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family CorA PF01544.13 EFX06619.1 - 2.1 7.3 8.5 3.1 6.7 5.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Filament PF00038.16 EFX06619.1 - 2.1 7.7 27.6 0.15 11.4 12.4 2.4 2 1 1 3 3 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.4 EFX06619.1 - 2.3 8.0 33.1 0.31 10.8 8.5 2.5 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.17 EFX06619.1 - 2.6 8.0 30.1 3 7.8 4.0 3.0 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain BCAS2 PF05700.6 EFX06619.1 - 3.9 6.8 19.3 1.6 8.1 10.4 2.0 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) AAA_13 PF13166.1 EFX06619.1 - 4.2 5.7 24.8 0.14 10.5 3.5 2.3 2 1 1 3 3 3 0 AAA domain TMPIT PF07851.8 EFX06619.1 - 4.3 6.3 17.1 3.7 6.5 2.7 2.1 1 1 1 2 2 2 0 TMPIT-like protein NPV_P10 PF05531.7 EFX06619.1 - 4.3 7.6 11.2 14 5.9 3.9 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Nsp1_C PF05064.8 EFX06619.1 - 4.6 6.9 16.9 0.46 10.1 7.3 2.4 2 1 1 3 3 2 0 Nsp1-like C-terminal region bZIP_1 PF00170.16 EFX06619.1 - 5 7.1 18.2 3.8 7.5 2.5 3.8 1 1 1 3 3 3 0 bZIP transcription factor Rootletin PF15035.1 EFX06619.1 - 5.6 6.9 23.1 41 4.0 16.0 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF2937 PF11157.3 EFX06619.1 - 7.1 5.9 8.2 2.3 7.5 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) DUF3708 PF12501.3 EFX06619.1 - 7.6 6.3 6.2 10 5.9 2.7 2.0 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter Jnk-SapK_ap_N PF09744.4 EFX06619.1 - 7.9 6.4 29.5 2.4 8.1 9.8 2.5 2 1 1 3 3 2 0 JNK_SAPK-associated protein-1 DUF3450 PF11932.3 EFX06619.1 - 9.4 5.4 21.5 22 4.1 8.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) zf-TRAF PF02176.13 EFX06620.1 - 2.3e-08 34.2 5.8 2.3e-08 34.2 4.0 3.9 2 1 3 5 5 5 4 TRAF-type zinc finger zf-C3HC4_2 PF13923.1 EFX06620.1 - 5.4e-07 29.5 5.8 5.4e-07 29.5 4.1 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EFX06620.1 - 5.7e-07 29.0 6.5 5.7e-07 29.0 4.5 4.1 3 1 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EFX06620.1 - 2.9e-06 26.9 4.9 2.9e-06 26.9 3.4 3.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.1 EFX06620.1 - 1.7e-05 24.3 3.5 1.7e-05 24.3 2.4 3.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EFX06620.1 - 0.00024 20.7 4.0 0.00024 20.7 2.8 3.3 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 EFX06620.1 - 0.0012 18.5 6.2 0.0067 16.1 4.3 2.4 1 0 0 1 1 1 1 RING-type zinc-finger RdRP_2 PF00978.16 EFX06620.1 - 0.024 13.3 0.1 0.043 12.4 0.1 1.3 1 0 0 1 1 1 0 RNA dependent RNA polymerase zf-P11 PF03854.9 EFX06620.1 - 0.031 13.7 0.5 0.031 13.7 0.4 3.1 2 1 1 3 3 3 0 P-11 zinc finger zf-C3HC4_4 PF15227.1 EFX06620.1 - 0.037 13.8 15.3 0.044 13.6 4.6 3.0 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Mito_carr PF00153.22 EFX06621.1 - 3.4e-46 154.8 8.5 4.2e-17 61.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3533 PF12051.3 EFX06623.1 - 1e-21 77.1 3.9 1.3e-21 76.8 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Y_phosphatase PF00102.22 EFX06625.1 - 3.7e-58 196.6 0.0 2.6e-31 108.7 0.0 3.4 3 1 0 3 3 3 3 Protein-tyrosine phosphatase Rhodanese PF00581.15 EFX06625.1 - 1.8e-10 41.1 0.0 4.5e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase3 PF13350.1 EFX06625.1 - 0.022 14.9 0.1 0.065 13.4 0.1 1.8 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.15 EFX06625.1 - 0.043 13.4 0.1 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Cyto_heme_lyase PF01265.12 EFX06626.1 - 3.1e-80 269.5 0.4 6.1e-80 268.5 0.2 1.4 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase PAT1 PF09770.4 EFX06626.1 - 0.35 9.0 6.3 0.41 8.8 4.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_TAF50 PF03326.8 EFX06626.1 - 1.4 7.7 12.2 1.9 7.3 8.4 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) MFS_1 PF07690.11 EFX06627.1 - 2.2e-14 52.9 7.3 2.2e-14 52.9 5.0 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.8 EFX06627.1 - 3e-06 26.6 8.0 0.00065 19.0 0.4 3.4 3 0 0 3 3 3 2 Nodulin-like DUF3089 PF11288.3 EFX06628.1 - 0.002 17.3 0.0 0.0021 17.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Abhydrolase_6 PF12697.2 EFX06628.1 - 0.0022 17.8 0.0 0.0027 17.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 EFX06628.1 - 0.0025 17.1 0.0 0.0029 16.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_5 PF12695.2 EFX06628.1 - 0.11 12.1 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Glyco_hydro_43 PF04616.9 EFX06629.1 - 3.4e-36 124.7 1.3 4.9e-36 124.3 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF3498 PF12004.3 EFX06630.1 - 0.0025 17.0 8.6 0.0025 17.0 6.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3498) MIP-T3 PF10243.4 EFX06630.1 - 0.88 7.9 9.0 0.97 7.8 6.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 eIF-3_zeta PF05091.7 EFX06630.1 - 2.6 6.5 7.3 3.3 6.2 5.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) 2-Hacid_dh_C PF02826.14 EFX06631.1 - 2.2e-44 150.7 0.0 2.9e-44 150.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX06631.1 - 0.00024 20.5 0.0 0.00055 19.4 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.1 EFX06631.1 - 0.04 14.2 0.1 0.13 12.5 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_7 PF13241.1 EFX06631.1 - 0.058 13.6 0.0 0.15 12.3 0.0 1.6 2 0 0 2 2 2 0 Putative NAD(P)-binding ELFV_dehydrog PF00208.16 EFX06631.1 - 0.08 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Met_10 PF02475.11 EFX06632.1 - 0.00061 19.4 0.0 0.0032 17.0 0.0 2.0 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_26 PF13659.1 EFX06632.1 - 0.011 15.8 3.2 0.05 13.6 2.2 2.3 1 1 0 1 1 1 0 Methyltransferase domain p450 PF00067.17 EFX06633.1 - 8.8e-63 212.4 0.0 1.1e-62 212.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M41 PF01434.13 EFX06634.1 - 8.6e-68 227.9 0.1 1.8e-67 226.9 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EFX06634.1 - 3e-37 127.7 0.0 6.8e-37 126.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EFX06634.1 - 4.3e-06 26.5 0.1 1.7e-05 24.5 0.0 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EFX06634.1 - 9.5e-06 25.7 0.2 5.7e-05 23.1 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EFX06634.1 - 2.8e-05 24.9 0.0 7.6e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 EFX06634.1 - 4.8e-05 22.2 0.0 9.3e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 EFX06634.1 - 0.00017 21.7 0.3 0.042 14.0 0.0 3.2 2 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 EFX06634.1 - 0.0013 17.8 0.8 0.03 13.3 0.3 2.3 1 1 1 2 2 2 1 Zeta toxin RuvB_N PF05496.7 EFX06634.1 - 0.0015 17.6 0.0 0.0027 16.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 EFX06634.1 - 0.0016 17.8 0.3 0.0039 16.6 0.2 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 EFX06634.1 - 0.0022 17.6 0.3 0.0084 15.8 0.2 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 EFX06634.1 - 0.0031 17.4 0.0 0.0091 15.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EFX06634.1 - 0.01 15.7 0.0 0.027 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_25 PF13481.1 EFX06634.1 - 0.011 15.1 1.5 0.19 11.1 0.4 2.3 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.1 EFX06634.1 - 0.014 15.3 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EFX06634.1 - 0.018 14.2 0.2 0.036 13.2 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 EFX06634.1 - 0.029 14.6 0.0 0.065 13.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EFX06634.1 - 0.056 13.3 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EFX06634.1 - 0.18 11.4 0.5 1.5 8.4 0.1 2.3 2 0 0 2 2 2 0 NACHT domain Pyr_redox_3 PF13738.1 EFX06635.1 - 1e-23 84.4 0.1 1.9e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX06635.1 - 1.7e-13 49.6 0.0 4.3e-13 48.3 0.0 1.5 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.1 EFX06635.1 - 1.7e-07 30.4 0.0 4.8e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 EFX06635.1 - 1.1e-06 28.5 0.1 1.2e-05 25.2 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.14 EFX06635.1 - 0.0093 15.1 0.0 0.018 14.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3748 PF12566.3 EFX06635.1 - 0.022 14.6 0.1 0.053 13.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) Pyr_redox_2 PF07992.9 EFX06635.1 - 0.1 12.4 0.0 0.31 10.8 0.0 2.0 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EFX06635.1 - 0.12 11.2 0.1 4.3 6.0 0.3 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_7 PF13241.1 EFX06635.1 - 0.17 12.1 0.5 0.38 11.0 0.0 1.8 2 0 0 2 2 1 0 Putative NAD(P)-binding Thi4 PF01946.12 EFX06635.1 - 0.32 10.0 1.8 0.6 9.1 0.3 1.9 2 0 0 2 2 2 0 Thi4 family NAD_binding_9 PF13454.1 EFX06635.1 - 0.35 10.6 7.8 3 7.6 1.9 3.9 4 1 0 4 4 4 0 FAD-NAD(P)-binding DAO PF01266.19 EFX06635.1 - 4.2 6.1 10.1 4.2 6.1 1.4 2.9 1 1 1 2 2 2 0 FAD dependent oxidoreductase Cellulase PF00150.13 EFX06636.1 - 2.4e-44 151.6 0.0 3.7e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Macoilin PF09726.4 EFX06636.1 - 1.7 6.8 11.0 2.1 6.5 7.6 1.1 1 0 0 1 1 1 0 Transmembrane protein Golgin_A5 PF09787.4 EFX06636.1 - 4.4 5.7 13.8 5.9 5.2 9.6 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DNA_pol_viral_N PF00242.12 EFX06636.1 - 9.3 5.1 13.7 14 4.6 9.5 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain OTCace_N PF02729.16 EFX06637.1 - 6.1e-41 139.4 0.0 9e-41 138.8 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 EFX06637.1 - 1.8e-33 115.6 0.0 3e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Glyco_hydro_4 PF02056.11 EFX06637.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase AMP-binding PF00501.23 EFX06638.1 - 3.8e-45 154.0 0.0 5.7e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ABC_tran PF00005.22 EFX06639.1 - 5.6e-41 140.0 0.2 2.3e-27 95.9 0.0 2.6 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 EFX06639.1 - 6.2e-14 52.6 0.8 7.3e-06 26.1 0.1 3.3 2 1 0 2 2 2 2 AAA domain SMC_N PF02463.14 EFX06639.1 - 1.1e-10 41.1 1.8 0.00013 21.3 0.0 3.4 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EFX06639.1 - 6.8e-08 32.7 2.4 0.0019 18.2 0.3 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFX06639.1 - 9.9e-08 31.4 1.9 0.0064 15.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_membrane PF00664.18 EFX06639.1 - 1.5e-07 31.1 9.1 6.3e-06 25.7 0.9 4.4 4 2 0 4 4 3 2 ABC transporter transmembrane region AAA_22 PF13401.1 EFX06639.1 - 3e-07 30.6 1.2 0.025 14.7 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EFX06639.1 - 2.6e-06 28.2 0.0 0.087 13.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EFX06639.1 - 6e-06 25.5 0.5 0.026 13.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 EFX06639.1 - 8.7e-06 25.3 0.0 0.0093 15.4 0.0 2.4 2 0 0 2 2 2 2 AAA-like domain Dynamin_N PF00350.18 EFX06639.1 - 2.3e-05 24.2 0.5 0.0059 16.4 0.1 2.7 2 0 0 2 2 2 1 Dynamin family AAA_18 PF13238.1 EFX06639.1 - 2.5e-05 24.5 0.0 0.31 11.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EFX06639.1 - 3.3e-05 23.8 0.1 0.12 12.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 EFX06639.1 - 3.7e-05 24.2 0.1 0.15 12.5 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_25 PF13481.1 EFX06639.1 - 3.7e-05 23.2 0.1 0.34 10.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EFX06639.1 - 5e-05 23.7 1.0 0.19 12.0 0.2 2.5 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 EFX06639.1 - 9e-05 21.4 0.2 0.12 11.2 0.1 2.4 2 1 0 2 2 2 2 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 EFX06639.1 - 0.00016 21.1 0.5 0.27 10.6 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family DUF87 PF01935.12 EFX06639.1 - 0.00075 19.3 1.1 0.074 12.8 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF87 MobB PF03205.9 EFX06639.1 - 0.0011 18.7 0.2 0.55 9.9 0.1 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EFX06639.1 - 0.0018 18.1 0.0 0.2 11.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 EFX06639.1 - 0.0032 17.0 0.1 1.7 8.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EFX06639.1 - 0.0051 16.4 0.6 1.2 8.7 0.0 2.8 3 0 0 3 3 2 1 NACHT domain Zeta_toxin PF06414.7 EFX06639.1 - 0.0053 15.8 0.2 0.2 10.7 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin cobW PF02492.14 EFX06639.1 - 0.0067 15.8 1.8 0.054 12.9 0.2 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Adeno_IVa2 PF02456.10 EFX06639.1 - 0.0095 14.6 0.1 0.2 10.2 0.0 2.2 2 0 0 2 2 2 1 Adenovirus IVa2 protein Arch_ATPase PF01637.13 EFX06639.1 - 0.011 15.3 0.1 0.58 9.8 0.0 2.5 3 0 0 3 3 2 0 Archaeal ATPase AAA_19 PF13245.1 EFX06639.1 - 0.017 14.8 0.3 1 9.1 0.0 3.0 3 0 0 3 3 2 0 Part of AAA domain AAA_14 PF13173.1 EFX06639.1 - 0.022 14.6 0.3 0.66 9.8 0.0 2.9 3 1 0 3 3 2 0 AAA domain AAA_5 PF07728.9 EFX06639.1 - 0.023 14.3 1.3 7.5 6.2 0.1 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA PF00004.24 EFX06639.1 - 0.031 14.4 0.1 18 5.5 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 EFX06639.1 - 0.034 13.7 0.1 9.2 5.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.1 EFX06639.1 - 0.1 12.5 0.0 4.2 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 EFX06639.1 - 0.12 11.8 0.1 2.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA12 PF10443.4 EFX06639.1 - 0.15 10.5 0.2 0.58 8.5 0.0 1.9 2 0 0 2 2 2 0 RNA12 protein Mg_chelatase PF01078.16 EFX06639.1 - 0.15 11.1 0.1 7.2 5.7 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EFX06639.1 - 0.16 12.1 0.0 28 4.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Pox_A32 PF04665.7 EFX06639.1 - 0.26 10.5 0.9 31 3.7 0.1 3.0 3 0 0 3 3 3 0 Poxvirus A32 protein A_deaminase PF00962.17 EFX06640.1 - 2.7e-61 207.3 0.0 3.1e-61 207.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Acetyltransf_1 PF00583.19 EFX06641.1 - 2.4e-09 37.0 0.1 9.2e-09 35.2 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EFX06641.1 - 1.6e-07 31.3 0.0 4.1e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.1 EFX06641.1 - 1.6e-06 28.5 0.0 0.027 15.0 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EFX06641.1 - 0.00054 19.8 0.0 0.0014 18.4 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EFX06641.1 - 0.001 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 EFX06641.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.1 EFX06641.1 - 0.003 17.6 0.0 0.0055 16.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EFX06641.1 - 0.032 14.3 0.0 0.32 11.1 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.1 EFX06641.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 LEA_6 PF10714.4 EFX06641.1 - 0.26 11.1 1.1 0.8 9.5 0.2 2.1 2 1 1 3 3 3 0 Late embryogenesis abundant protein 18 Phosphoesterase PF04185.9 EFX06642.1 - 8.6e-33 114.0 1.4 1.6e-32 113.1 1.0 1.4 1 1 0 1 1 1 1 Phosphoesterase family Sulfatase PF00884.18 EFX06642.1 - 0.017 14.3 0.1 0.035 13.2 0.1 1.4 1 1 0 1 1 1 0 Sulfatase Ribosomal_S8e PF01201.17 EFX06643.1 - 3.4e-49 166.3 1.4 3.9e-49 166.1 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e SMAP PF15477.1 EFX06643.1 - 0.087 13.1 2.9 0.41 10.9 2.0 2.1 1 1 0 1 1 1 0 Small acidic protein family Hc1 PF07432.8 EFX06643.1 - 2.2 8.4 7.7 0.32 11.1 0.6 2.1 2 0 0 2 2 2 0 Histone H1-like protein Hc1 ABC_tran PF00005.22 EFX06644.1 - 5.1e-43 146.6 0.0 1.1e-24 87.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EFX06644.1 - 7.4e-28 97.7 20.9 6.1e-18 65.1 2.9 2.8 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.14 EFX06644.1 - 2.7e-09 36.5 1.0 0.063 12.4 0.0 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.13 EFX06644.1 - 5.3e-09 35.8 0.1 0.00015 21.3 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_25 PF13481.1 EFX06644.1 - 3.1e-08 33.2 0.9 0.00039 19.8 0.1 3.1 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 EFX06644.1 - 1.3e-07 31.7 3.4 8.9e-05 22.5 0.6 3.0 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EFX06644.1 - 2e-07 30.4 1.0 0.019 14.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 EFX06644.1 - 2.1e-07 31.2 0.0 0.89 9.4 0.3 4.1 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.1 EFX06644.1 - 4.8e-07 29.7 0.5 0.00041 20.2 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EFX06644.1 - 2.3e-06 27.7 0.1 0.0084 16.2 0.0 2.9 2 1 0 2 2 2 2 AAA domain T2SE PF00437.15 EFX06644.1 - 3.9e-06 25.9 0.2 0.031 13.1 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein Dynamin_N PF00350.18 EFX06644.1 - 4.6e-06 26.5 1.5 0.027 14.2 0.1 2.6 2 0 0 2 2 2 2 Dynamin family Viral_helicase1 PF01443.13 EFX06644.1 - 1.2e-05 24.9 0.3 0.084 12.3 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 EFX06644.1 - 1.2e-05 25.6 0.0 0.011 16.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EFX06644.1 - 2.6e-05 23.8 0.4 0.24 10.8 0.0 2.7 3 0 0 3 3 3 2 AAA-like domain MMR_HSR1 PF01926.18 EFX06644.1 - 2.6e-05 24.1 0.3 0.026 14.4 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 EFX06644.1 - 4.9e-05 22.5 1.0 0.15 11.2 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 EFX06644.1 - 5.4e-05 23.6 0.2 0.13 12.7 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein cobW PF02492.14 EFX06644.1 - 0.00013 21.4 0.6 0.35 10.2 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 EFX06644.1 - 0.00036 20.2 2.5 0.04 13.6 0.1 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.12 EFX06644.1 - 0.00042 20.1 7.3 0.0028 17.4 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_17 PF13207.1 EFX06644.1 - 0.00045 21.0 2.4 0.29 11.9 0.0 2.9 2 1 0 2 2 2 1 AAA domain NACHT PF05729.7 EFX06644.1 - 0.00057 19.5 0.5 0.5 10.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.1 EFX06644.1 - 0.0006 19.4 4.5 0.31 10.5 0.5 3.9 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EFX06644.1 - 0.00073 19.8 0.3 0.91 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.4 EFX06644.1 - 0.00085 18.0 1.4 0.13 10.8 0.0 3.4 4 0 0 4 4 4 1 Predicted ATPase of the ABC class SbcCD_C PF13558.1 EFX06644.1 - 0.0015 18.4 0.3 2.8 7.9 0.0 3.8 3 1 0 3 3 2 1 Putative exonuclease SbcCD, C subunit Pox_A32 PF04665.7 EFX06644.1 - 0.0018 17.6 0.4 0.58 9.4 0.0 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein TrwB_AAD_bind PF10412.4 EFX06644.1 - 0.0042 15.7 0.6 1.7 7.1 0.0 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain Adeno_IVa2 PF02456.10 EFX06644.1 - 0.008 14.8 0.0 2.8 6.5 0.0 2.2 2 0 0 2 2 2 1 Adenovirus IVa2 protein AAA_14 PF13173.1 EFX06644.1 - 0.019 14.8 0.1 4.8 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EFX06644.1 - 0.022 13.8 0.1 1.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Arch_ATPase PF01637.13 EFX06644.1 - 0.049 13.3 0.1 12 5.5 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase DAP3 PF10236.4 EFX06644.1 - 0.055 12.3 1.5 4 6.2 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Septin PF00735.13 EFX06644.1 - 0.099 11.6 0.3 1.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.10 EFX06644.1 - 0.12 12.1 1.8 6.7 6.3 0.0 2.4 2 0 0 2 2 2 0 NTPase NB-ARC PF00931.17 EFX06644.1 - 0.17 10.7 1.1 0.95 8.2 0.1 2.4 3 0 0 3 3 2 0 NB-ARC domain AAA_24 PF13479.1 EFX06644.1 - 0.22 11.0 0.6 14 5.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Herpes_US9 PF06072.6 EFX06644.1 - 0.33 10.8 3.5 0.27 11.0 0.4 2.5 2 0 0 2 2 1 0 Alphaherpesvirus tegument protein US9 AAA_28 PF13521.1 EFX06644.1 - 0.54 10.1 4.4 5.7 6.8 0.5 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EFX06644.1 - 0.68 9.6 3.1 21 4.8 0.1 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 EFX06644.1 - 0.75 8.7 1.8 2.3 7.0 0.2 2.2 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AIG1 PF04548.11 EFX06644.1 - 1.2 8.2 2.3 9.2 5.2 0.1 2.5 2 0 0 2 2 2 0 AIG1 family ATP_bind_1 PF03029.12 EFX06644.1 - 1.4 8.4 3.4 7.2 6.0 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DENN PF02141.16 EFX06645.1 - 2.7e-39 134.8 0.0 4.4e-39 134.1 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain zf-HIT PF04438.11 EFX06645.1 - 4.2e-10 39.0 9.8 7.3e-10 38.3 6.8 1.4 1 0 0 1 1 1 1 HIT zinc finger uDENN PF03456.13 EFX06645.1 - 1e-05 25.3 0.5 5.7e-05 22.9 0.0 2.6 2 0 0 2 2 2 1 uDENN domain Elongin_A PF06881.6 EFX06645.1 - 0.006 16.9 2.6 0.006 16.9 1.8 2.3 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A zf-MYND PF01753.13 EFX06645.1 - 0.012 15.4 7.4 0.026 14.3 5.1 1.5 1 0 0 1 1 1 0 MYND finger DUF2570 PF10828.3 EFX06645.1 - 0.93 9.1 10.3 0.22 11.1 4.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) DivIVA PF05103.8 EFX06645.1 - 7 6.7 14.4 1.3 9.0 4.7 2.6 1 1 1 2 2 2 0 DivIVA protein LIP PF03583.9 EFX06646.1 - 5.2e-85 285.1 0.1 7.8e-85 284.5 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_5 PF12695.2 EFX06646.1 - 0.0046 16.7 0.1 0.0086 15.8 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ufd2P_core PF10408.4 EFX06648.1 - 6.6e-188 625.8 0.0 8e-188 625.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 EFX06648.1 - 2.6e-26 91.3 0.8 9e-26 89.6 0.5 2.0 1 0 0 1 1 1 1 U-box domain OmpH PF03938.9 EFX06648.1 - 0.0069 16.3 3.8 0.0069 16.3 2.7 2.1 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Cytochrom_B558a PF05038.8 EFX06648.1 - 0.35 10.4 1.8 0.77 9.3 1.2 1.5 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit DUF3757 PF12582.3 EFX06649.1 - 0.048 13.8 0.0 0.13 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3757) OAR PF03826.12 EFX06649.1 - 0.15 11.5 0.3 0.37 10.3 0.2 1.7 1 0 0 1 1 1 0 OAR domain P21-Arc PF04062.9 EFX06650.1 - 9.1e-79 263.2 0.0 1.6e-78 262.4 0.0 1.4 2 0 0 2 2 2 1 ARP2/3 complex ARPC3 (21 kDa) subunit tRNA-synt_His PF13393.1 EFX06651.1 - 4.2e-40 137.7 0.4 1e-33 116.7 0.0 2.0 2 0 0 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 EFX06651.1 - 9.8e-18 64.3 0.0 1.8e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EFX06651.1 - 3.1e-07 30.2 0.0 6.6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 EFX06651.1 - 2.6e-05 23.1 0.0 0.0082 14.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 EFX06651.1 - 0.09 11.9 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) 2OG-FeII_Oxy_2 PF13532.1 EFX06651.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily MRP-S25 PF13741.1 EFX06654.1 - 7.1e-72 241.6 3.9 6.3e-65 218.8 1.8 2.0 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 PRMT5 PF05185.11 EFX06655.1 - 2.7e-162 540.7 0.0 3.6e-162 540.3 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase DUF3445 PF11927.3 EFX06656.1 - 1.7e-55 188.1 0.0 1.4e-43 149.1 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3445) Abhydrolase_6 PF12697.2 EFX06657.1 - 5e-25 88.7 10.0 5e-25 88.7 6.9 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX06657.1 - 0.00026 20.7 0.4 0.00063 19.5 0.3 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX06657.1 - 0.00028 20.5 0.5 0.0012 18.4 0.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold EthD PF07110.6 EFX06657.1 - 0.0069 17.2 0.1 0.24 12.3 0.0 3.2 2 1 0 2 2 2 1 EthD domain Ndr PF03096.9 EFX06657.1 - 0.068 11.6 0.0 0.23 9.9 0.0 1.7 1 1 0 1 1 1 0 Ndr family zf-H2C2_2 PF13465.1 EFX06658.1 - 8.5e-19 66.8 23.6 3.5e-07 30.1 0.6 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 EFX06658.1 - 1.6e-15 56.3 31.2 6.9e-06 26.1 0.1 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EFX06658.1 - 1.7e-06 27.8 26.9 0.027 14.7 0.1 5.1 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EFX06658.1 - 0.03 14.4 3.6 7 6.9 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EFX06658.1 - 0.43 10.8 9.9 8.2 6.7 0.1 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-TRAF PF02176.13 EFX06658.1 - 1 9.7 12.3 0.18 12.2 3.0 3.0 1 1 2 3 3 3 0 TRAF-type zinc finger CHORD PF04968.7 EFX06658.1 - 2.7 8.2 11.1 5.5 7.3 0.3 3.6 1 1 2 3 3 3 0 CHORD Amidase PF01425.16 EFX06659.1 - 1.2e-78 264.9 0.0 4e-78 263.2 0.0 1.7 2 0 0 2 2 2 1 Amidase DUF1244 PF06844.6 EFX06659.1 - 0.04 13.7 0.1 0.093 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) Cytochrom_B561 PF03188.11 EFX06660.1 - 0.021 14.6 0.2 0.034 13.9 0.2 1.2 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 COX14 PF14880.1 EFX06660.1 - 0.048 13.2 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF2668 PF10873.3 EFX06660.1 - 0.056 13.6 0.3 0.056 13.6 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2668) PTR2 PF00854.16 EFX06661.1 - 1.8e-24 86.2 0.1 1.3e-11 43.8 0.0 2.4 1 1 1 2 2 2 2 POT family NAD_binding_5 PF07994.7 EFX06661.1 - 0.035 13.6 0.0 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase G_glu_transpept PF01019.16 EFX06662.1 - 1.2e-149 499.0 4.7 1.4e-149 498.8 3.3 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Ribosomal_S25 PF03297.10 EFX06663.1 - 2.7e-39 133.4 7.2 3e-39 133.2 5.0 1.0 1 0 0 1 1 1 1 S25 ribosomal protein RNA_pol_Rpc34 PF05158.7 EFX06663.1 - 0.00039 19.7 0.7 0.00052 19.3 0.2 1.3 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_24 PF13412.1 EFX06663.1 - 0.013 14.8 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 EFX06663.1 - 0.019 14.6 0.1 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 MarR family TrmB PF01978.14 EFX06663.1 - 0.025 14.2 0.5 0.032 13.9 0.4 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.7 EFX06663.1 - 0.042 13.3 0.2 0.061 12.8 0.1 1.4 1 1 0 1 1 1 0 DeoR-like helix-turn-helix domain FeoC PF09012.5 EFX06663.1 - 0.052 13.2 0.7 0.12 12.0 0.1 1.8 1 1 1 2 2 2 0 FeoC like transcriptional regulator GatB_Yqey PF02637.13 EFX06663.1 - 0.064 12.9 0.3 0.086 12.5 0.2 1.3 1 1 0 1 1 1 0 GatB domain Rrf2 PF02082.15 EFX06663.1 - 0.094 12.8 0.1 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_11 PF08279.7 EFX06663.1 - 0.095 12.3 0.1 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 HTH domain DDRGK PF09756.4 EFX06663.1 - 0.2 11.0 2.5 0.3 10.4 1.7 1.3 1 1 0 1 1 1 0 DDRGK domain Pex14_N PF04695.8 EFX06664.1 - 2.8e-15 56.5 0.5 2.8e-15 56.5 0.3 3.4 2 2 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RecX PF02631.11 EFX06664.1 - 0.0044 17.2 0.0 0.0081 16.3 0.0 1.4 1 0 0 1 1 1 1 RecX family Spp-24 PF07448.6 EFX06664.1 - 1 9.3 3.7 2.6 7.9 2.5 1.7 1 1 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) Coprogen_oxidas PF01218.13 EFX06665.1 - 3.6e-119 396.7 0.0 5.1e-119 396.2 0.0 1.2 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase WLM PF08325.5 EFX06666.1 - 2.1e-42 145.0 0.0 3.6e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.12 EFX06666.1 - 0.002 17.9 0.7 0.002 17.9 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function DUF45 Aminotran_5 PF00266.14 EFX06666.1 - 0.013 14.2 0.0 0.019 13.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Peptidase_MA_2 PF13485.1 EFX06666.1 - 0.032 14.2 0.6 0.085 12.9 0.1 2.0 2 0 0 2 2 2 0 Peptidase MA superfamily SprT-like PF10263.4 EFX06666.1 - 0.036 13.7 0.2 0.062 12.9 0.1 1.4 1 0 0 1 1 1 0 SprT-like family HET PF06985.6 EFX06667.1 - 1.9e-18 66.9 0.0 6.6e-18 65.2 0.0 2.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.2 EFX06667.1 - 3.5e-13 49.6 0.4 1.4e-06 28.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX06667.1 - 1.1e-09 38.4 0.8 0.00079 19.8 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 EFX06667.1 - 2.2e-08 33.5 3.5 0.0018 17.9 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 EFX06667.1 - 6.8e-07 28.9 0.6 0.07 13.4 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 EFX06667.1 - 0.00046 20.3 6.3 0.44 10.8 0.1 3.8 2 1 3 5 5 5 4 Ankyrin repeats (many copies) adh_short PF00106.20 EFX06668.1 - 2e-13 50.5 4.7 2.2e-13 50.4 1.6 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EFX06668.1 - 6.7e-08 32.4 2.1 1e-07 31.8 0.5 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.16 EFX06668.1 - 0.0062 16.0 0.0 0.013 14.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Perilipin PF03036.11 EFX06670.1 - 0.00021 20.2 0.0 0.00023 20.1 0.0 1.3 1 0 0 1 1 1 1 Perilipin family Ank PF00023.25 EFX06671.1 - 1.8e-60 197.8 10.8 8.5e-09 34.7 0.0 7.9 7 0 0 7 7 7 7 Ankyrin repeat Ank_2 PF12796.2 EFX06671.1 - 2.5e-57 191.1 8.2 1.4e-20 73.4 0.1 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EFX06671.1 - 3.4e-40 135.7 11.3 2.9e-10 40.3 0.0 7.0 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 EFX06671.1 - 1.9e-38 126.5 4.8 0.00011 22.0 0.0 8.2 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.1 EFX06671.1 - 1.2e-30 104.8 8.3 1.2e-10 41.2 0.2 6.4 1 1 4 6 6 6 6 Ankyrin repeats (many copies) NACHT PF05729.7 EFX06671.1 - 1.8e-05 24.5 0.1 0.0021 17.7 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EFX06671.1 - 0.013 15.5 0.0 0.067 13.1 0.0 2.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.2 EFX06671.1 - 0.1 11.9 0.0 17 4.7 0.0 2.4 1 1 1 2 2 2 0 AAA-like domain LrgA PF03788.9 EFX06672.1 - 0.95 9.2 6.1 0.47 10.1 2.7 1.7 1 1 0 1 1 1 0 LrgA family WD40 PF00400.27 EFX06673.1 - 8.6e-20 69.8 0.1 1.6e-05 24.6 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat SRA1 PF07304.6 EFX06673.1 - 2.8e-09 36.8 0.0 7.3e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.2 EFX06673.1 - 2.6e-06 27.4 0.3 4.4e-06 26.6 0.2 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 DUF3328 PF11807.3 EFX06675.1 - 1.8e-34 119.3 0.1 2.1e-34 119.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2306 PF10067.4 EFX06675.1 - 0.12 12.5 0.6 0.41 10.7 0.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2306) DUF865 PF05906.6 EFX06675.1 - 5.2 6.7 5.6 6.6 6.3 1.0 2.5 2 0 0 2 2 2 0 Herpesvirus-7 repeat of unknown function (DUF865) Fungal_trans PF04082.13 EFX06676.1 - 3.3e-14 52.4 0.0 4.9e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain TGF_beta_GS PF08515.7 EFX06676.1 - 7.7 5.9 10.6 24 4.3 0.2 2.8 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif DUF2407_C PF13373.1 EFX06677.1 - 5.5e-32 110.5 0.0 9.1e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.4 EFX06677.1 - 7.4e-17 61.3 0.0 2e-15 56.7 0.0 2.6 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.18 EFX06677.1 - 0.13 11.7 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Ribosomal_L19e PF01280.15 EFX06677.1 - 6.8 6.4 7.9 0.13 12.0 0.7 1.7 2 0 0 2 2 2 0 Ribosomal protein L19e ER_lumen_recept PF00810.13 EFX06678.1 - 2.2e-54 183.9 8.0 3.5e-54 183.2 5.5 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.9 EFX06678.1 - 0.013 15.0 10.8 0.28 10.7 0.6 3.6 3 1 1 4 4 4 0 PQ loop repeat Aminotran_1_2 PF00155.16 EFX06679.1 - 1.1e-65 221.9 0.0 2.7e-65 220.6 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II AA_permease PF00324.16 EFX06681.1 - 2.3e-97 326.3 34.5 2.7e-97 326.0 23.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EFX06681.1 - 1.1e-30 106.5 37.9 1.5e-30 106.1 26.3 1.0 1 0 0 1 1 1 1 Amino acid permease RNA_pol_Rpb1_5 PF04998.12 EFX06682.1 - 1.2e-87 293.7 0.0 2.9e-87 292.4 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EFX06682.1 - 1e-63 214.2 0.1 1.9e-63 213.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 DDHD PF02862.12 EFX06682.1 - 3.2e-38 131.7 0.2 4.4e-34 118.2 0.0 4.2 3 1 0 3 3 3 1 DDHD domain RNA_pol_Rpb1_1 PF04997.7 EFX06682.1 - 1.5e-31 109.9 0.2 8.1e-20 71.3 0.0 3.1 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.13 EFX06682.1 - 5.7e-28 97.6 0.0 1.5e-27 96.2 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EFX06682.1 - 2.9e-15 55.9 0.0 1.2e-14 53.9 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Abhydrolase_6 PF12697.2 EFX06682.1 - 0.00068 19.5 0.9 0.0033 17.3 0.1 2.6 2 1 0 2 2 2 1 Alpha/beta hydrolase family SGT1 PF07093.6 EFX06682.1 - 0.0007 18.1 3.4 0.0012 17.3 2.3 1.3 1 0 0 1 1 1 1 SGT1 protein Abhydrolase_5 PF12695.2 EFX06682.1 - 0.002 17.8 0.0 0.0069 16.1 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2305 PF10230.4 EFX06682.1 - 0.067 12.6 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Utp12 PF04003.7 EFX06683.1 - 3.9e-19 68.5 0.0 6.3e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF2638 PF10937.3 EFX06684.1 - 3.3e-32 111.8 0.2 4e-32 111.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2638) Skp1_POZ PF03931.10 EFX06685.1 - 2.3e-09 37.2 0.0 3.1e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Pyr_redox_3 PF13738.1 EFX06686.1 - 1.9e-26 93.3 0.0 3.2e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EFX06686.1 - 1.1e-17 63.4 0.2 1.9e-14 52.8 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EFX06686.1 - 4.6e-15 56.0 0.0 8.9e-12 45.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EFX06686.1 - 1.5e-12 47.3 0.6 6.7e-11 42.0 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EFX06686.1 - 1.3e-11 44.0 0.0 1.6e-10 40.4 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EFX06686.1 - 3.4e-08 33.4 2.8 0.0064 16.2 0.5 4.1 3 1 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.19 EFX06686.1 - 1.9e-06 27.0 3.5 0.0023 16.8 0.2 3.5 3 1 1 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.12 EFX06686.1 - 1.3e-05 24.4 0.5 0.011 14.8 0.1 2.4 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.22 EFX06686.1 - 6.4e-05 23.2 1.1 0.12 12.8 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX06686.1 - 0.00011 21.1 0.8 0.00036 19.4 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 EFX06686.1 - 0.00098 18.0 0.5 2.7 6.7 0.1 3.1 3 0 0 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.9 EFX06686.1 - 0.002 16.7 1.8 0.094 11.1 0.1 3.4 4 0 0 4 4 4 1 HI0933-like protein NAD_binding_7 PF13241.1 EFX06686.1 - 0.0052 17.0 0.0 1.1 9.5 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.7 EFX06686.1 - 0.021 13.7 0.3 0.64 8.8 0.0 2.9 3 1 0 3 3 3 0 Lycopene cyclase protein Shikimate_DH PF01488.15 EFX06686.1 - 0.021 14.9 0.2 9.2 6.3 0.0 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Amino_oxidase PF01593.19 EFX06686.1 - 0.032 13.3 0.0 3.6 6.5 0.0 2.9 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase ThiF PF00899.16 EFX06686.1 - 0.14 11.9 0.5 46 3.8 0.1 3.7 5 0 0 5 5 4 0 ThiF family ApbA PF02558.11 EFX06686.1 - 0.31 10.4 1.9 1.4 8.3 0.5 2.4 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA OCD_Mu_crystall PF02423.10 EFX06687.1 - 8.1e-15 54.3 3.8 7.9e-08 31.4 0.6 3.4 2 1 1 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.15 EFX06687.1 - 3.3e-08 33.7 0.8 1e-06 28.8 0.6 2.2 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.17 EFX06687.1 - 0.012 16.0 0.4 0.021 15.3 0.3 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Saccharop_dh PF03435.13 EFX06687.1 - 0.02 13.9 0.2 0.027 13.4 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NmrA PF05368.8 EFX06687.1 - 0.026 13.7 0.2 0.037 13.2 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family Abhydrolase_6 PF12697.2 EFX06688.1 - 1.4e-27 97.1 5.9 2.2e-27 96.3 4.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX06688.1 - 1e-11 44.8 0.2 2.1e-11 43.8 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EFX06688.1 - 7.3e-10 38.7 0.0 6.4e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EFX06688.1 - 0.00049 19.6 0.0 0.13 11.7 0.0 2.7 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase DUF647 PF04884.9 EFX06688.1 - 0.15 11.1 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Vitamin B6 photo-protection and homoeostasis F-box PF00646.28 EFX06689.1 - 0.012 15.2 0.0 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.2 EFX06689.1 - 0.075 12.7 0.1 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 F-box-like GMC_oxred_N PF00732.14 EFX06690.1 - 1.4e-77 260.7 0.0 2e-77 260.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EFX06690.1 - 1.6e-36 125.7 0.0 3.6e-36 124.6 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EFX06690.1 - 2.6e-06 26.5 0.1 0.0018 17.2 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EFX06690.1 - 0.0022 17.0 0.1 0.0036 16.2 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 EFX06690.1 - 0.0071 15.2 0.2 2.6 6.8 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain TrkA_N PF02254.13 EFX06690.1 - 0.083 12.8 0.1 0.2 11.6 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_8 PF13450.1 EFX06690.1 - 0.11 12.5 0.2 0.36 10.8 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EFX06690.1 - 0.18 12.1 0.2 0.46 10.9 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ald_Xan_dh_C2 PF02738.13 EFX06691.1 - 0.045 12.0 0.4 0.08 11.2 0.3 1.3 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase F-box-like PF12937.2 EFX06692.1 - 0.0013 18.4 0.1 0.0023 17.6 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EFX06692.1 - 0.0022 17.5 0.9 0.0022 17.5 0.6 2.0 2 0 0 2 2 2 1 F-box domain BC10 PF06726.7 EFX06693.1 - 5e-17 61.6 11.3 7.8e-17 61.0 7.9 1.3 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Cir_N PF10197.4 EFX06694.1 - 0.018 15.0 1.1 0.018 15.0 0.7 4.2 3 1 0 3 3 3 0 N-terminal domain of CBF1 interacting co-repressor CIR Glyco_hydro_18 PF00704.23 EFX06695.1 - 4.6e-68 230.1 4.6 6.9e-68 229.6 3.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Abhydrolase_6 PF12697.2 EFX06696.1 - 1.3e-26 93.9 9.8 1.5e-26 93.6 6.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EFX06696.1 - 4.2e-12 46.0 0.6 8.8e-12 44.9 0.4 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EFX06696.1 - 1.7e-08 34.2 0.0 2.6e-07 30.4 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 EFX06696.1 - 1.9e-08 34.0 0.0 1e-07 31.6 0.0 2.0 2 0 0 2 2 2 1 Putative lysophospholipase DUF4448 PF14610.1 EFX06698.1 - 0.022 14.2 0.7 0.051 13.0 0.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Peptidase_M56 PF05569.6 EFX06698.1 - 0.05 12.5 0.0 0.05 12.5 0.0 2.4 1 1 1 2 2 2 0 BlaR1 peptidase M56 SKG6 PF08693.5 EFX06698.1 - 1.2 8.5 6.4 8.2 5.8 4.4 2.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rifin_STEVOR PF02009.11 EFX06698.1 - 1.6 8.2 25.9 1 8.9 1.6 2.2 1 1 1 2 2 2 0 Rifin/stevor family FAM196 PF15265.1 EFX06698.1 - 9.4 5.3 21.0 12 4.9 14.6 1.1 1 0 0 1 1 1 0 FAM196 family Pkinase PF00069.20 EFX06699.1 - 1.1e-16 60.8 0.0 1.4e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 EFX06699.1 - 0.011 15.4 0.2 0.07 12.8 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 EFX06699.1 - 0.012 14.7 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.9 EFX06699.1 - 0.089 11.8 0.4 0.18 10.8 0.2 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhyH PF05721.8 EFX06701.1 - 3.7e-20 72.8 0.0 4.4e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.7 EFX06701.1 - 0.13 10.7 0.0 0.21 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) 2-Hacid_dh_C PF02826.14 EFX06702.1 - 3.4e-52 176.1 0.0 4.5e-52 175.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EFX06702.1 - 3.4e-16 58.9 0.0 4.2e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EFX06702.1 - 4.1e-07 29.9 0.1 9.4e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 EFX06702.1 - 0.0081 16.5 0.1 0.019 15.3 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 EFX06702.1 - 0.13 11.6 0.1 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 EFX06702.1 - 0.14 11.7 0.2 0.2 11.2 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Mito_carr PF00153.22 EFX06704.1 - 6.9e-67 221.2 2.9 7.7e-23 80.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein His_Phos_2 PF00328.17 EFX06705.1 - 3e-30 105.7 0.0 4e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) COX6B PF02297.12 EFX06706.1 - 5.5e-19 67.9 5.5 6.4e-19 67.7 3.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.9 EFX06706.1 - 0.0033 16.7 0.4 0.0046 16.3 0.2 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain ketoacyl-synt PF00109.21 EFX06706.1 - 0.074 12.5 0.0 0.077 12.4 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain CHCH PF06747.8 EFX06706.1 - 0.1 12.5 0.3 0.26 11.2 0.2 1.7 1 1 0 1 1 1 0 CHCH domain UPF0203 PF05254.7 EFX06706.1 - 2.4 8.0 5.3 4.9 7.0 0.8 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Ank_2 PF12796.2 EFX06707.1 - 1.3e-16 60.7 0.0 1.2e-10 41.5 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EFX06707.1 - 4.1e-16 57.8 0.0 4.9e-07 29.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 EFX06707.1 - 8.6e-12 44.0 0.1 0.0026 17.8 0.0 4.1 2 1 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 EFX06707.1 - 2.1e-10 40.4 0.0 2.9e-06 27.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EFX06707.1 - 2.1e-09 37.6 0.1 0.00042 20.7 0.0 3.2 2 1 0 2 2 2 2 Ankyrin repeats (many copies) CorA PF01544.13 EFX06707.1 - 3.7e-05 22.9 0.1 6.8e-05 22.0 0.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein IL32 PF15225.1 EFX06707.1 - 0.091 12.7 0.2 0.26 11.2 0.1 1.8 1 0 0 1 1 1 0 Interleukin 32 Fungal_trans PF04082.13 EFX06708.1 - 9.9e-14 50.8 0.0 1.9e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_8 PF13450.1 EFX06708.1 - 2.4e-08 33.8 0.5 7.3e-08 32.3 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX06708.1 - 3.8e-08 32.6 0.1 6.3e-08 31.9 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 EFX06708.1 - 1.4e-05 24.3 0.3 3.6e-05 23.0 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EFX06708.1 - 0.00042 20.2 0.1 0.00094 19.1 0.0 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EFX06708.1 - 0.0009 18.1 3.2 0.0018 17.1 2.1 1.6 1 1 1 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.14 EFX06708.1 - 0.0017 17.4 2.4 0.48 9.4 0.9 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.22 EFX06708.1 - 0.01 16.2 0.4 0.033 14.5 0.3 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 EFX06708.1 - 0.011 15.3 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.17 EFX06708.1 - 0.014 14.2 0.9 0.022 13.6 0.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Amino_oxidase PF01593.19 EFX06708.1 - 0.015 14.4 0.5 0.034 13.2 0.1 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase HI0933_like PF03486.9 EFX06708.1 - 0.026 13.0 1.1 0.038 12.4 0.8 1.2 1 0 0 1 1 1 0 HI0933-like protein IlvN PF07991.7 EFX06708.1 - 0.05 12.9 0.1 1.3 8.3 0.1 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Pyr_redox_3 PF13738.1 EFX06708.1 - 0.12 12.3 0.8 0.24 11.4 0.5 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 EFX06708.1 - 0.19 11.4 0.7 0.41 10.3 0.5 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lipase_GDSL_2 PF13472.1 EFX06710.1 - 2.4e-13 50.5 0.5 3.5e-13 50.0 0.3 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EFX06710.1 - 3.6e-10 40.0 0.7 6.9e-10 39.1 0.5 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.1 EFX06710.1 - 9.8e-07 28.6 0.2 2.5e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family FF PF01846.14 EFX06711.1 - 8.9e-10 38.3 0.1 8.9e-10 38.3 0.1 3.6 4 0 0 4 4 4 1 FF domain NAD_binding_8 PF13450.1 EFX06712.1 - 5.2e-09 36.0 0.3 7.3e-09 35.5 0.2 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EFX06712.1 - 5e-06 25.6 0.4 8.9e-06 24.8 0.3 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EFX06712.1 - 9.4e-06 24.9 0.1 9.8e-06 24.8 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.19 EFX06712.1 - 9.2e-05 21.4 0.8 9.2e-05 21.4 0.5 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EFX06712.1 - 0.00015 21.7 0.3 0.00017 21.5 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EFX06712.1 - 0.00018 20.7 0.1 0.00021 20.4 0.1 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 EFX06712.1 - 0.0003 21.1 0.1 0.00034 20.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EFX06712.1 - 0.00058 18.6 0.2 0.00066 18.4 0.2 1.0 1 0 0 1 1 1 1 Tryptophan halogenase NAD_binding_9 PF13454.1 EFX06712.1 - 0.0016 18.2 0.2 0.0018 18.0 0.1 1.2 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EFX06712.1 - 0.0037 17.3 0.2 0.0039 17.2 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 EFX06712.1 - 0.0059 16.4 0.3 0.0093 15.7 0.2 1.3 1 0 0 1 1 1 1 ThiF family GIDA PF01134.17 EFX06712.1 - 0.019 13.8 0.4 0.019 13.8 0.3 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.9 EFX06712.1 - 0.037 13.4 0.1 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.7 EFX06712.1 - 0.12 11.2 0.4 0.15 10.9 0.3 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Shikimate_DH PF01488.15 EFX06712.1 - 0.15 12.1 0.1 0.24 11.4 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.9 EFX06712.1 - 0.15 10.5 1.1 0.18 10.2 0.7 1.1 1 0 0 1 1 1 0 HI0933-like protein NAD_Gly3P_dh_N PF01210.18 EFX06712.1 - 0.16 11.6 0.7 0.16 11.6 0.5 1.3 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 EFX06712.1 - 0.39 11.1 2.8 0.73 10.2 0.5 1.9 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent